In most respects , all membranes and enamel matrix derivative ( EMD ) delivered better outcomes , in the range of 1 to 2 mm , than open flap debridement .
The use of any barrier type or EMD configuration was found to yield more Clinical Attachment Level ( CAL ) gain than any open flap configuration .
GTR was confirmed to be superior to open flap debridement
In a 1998 review article , Laurell and colleagues performed a meta- analysis of relevant guided tissue regeneration ( GTR ) articles over the previous 20 years ( 1 ) .
The purpose of the present research was to exp and on that work , particularly search ing for trends discriminating between bioabsorbable and non-bioabsorbable barriers , as well as the use of enamel matrix derivative , with respect to interproximal bony defects .
A clinical evaluation of demineralized freeze-dried bone allograft in combination with tetracycline in the treatment of periodontal osseous defects.
The purpose was to evaluate the use of demineralized freeze-dried bone allograft reconstituted with 50 mg/ml tetracycline hydrochloride in the treatment of intrabony periodontal defects . Fifteen systemically healthy patients ( 12 females , 3 males ; aged 35 to 61 ) with moderate-advanced periodontitis were treated . Patients had 3 osseous defects with probing depths ( PD ) > 5 mm after initial therapy . Each site in each subject was r and omly assigned to one of the following groups : 1 ) demineralized freeze-dried bone allograft reconstituted with 50 mg/ml tetracycline ( DFDBA + TCN ) ; 2 ) demineralized freeze-dried bone allograft alone ( DFDBA ) ; or 3 ) debridement only ( D ) . Clinical measurements were taken the day of surgery , 6 months , and 1 year . St and ardized radiographs were taken at baseline and 1 year and were evaluated by computer assisted densitometric image analysis ( CADIA ) . Clinical measurements included gingival recession , PD , clinical attachment level , and mobility . Osseous defect measurements were taken at baseline and at the 1 year reentry . No adverse healing responses occurred . The results showed that all patients had a statistically significant improvement in probing depth and attachment level at 1 year . Osseous measurements showed bone fill of 2.27 mm ( 51.6 % ) for the DFDBA + TCN group , 2.20 mm ( 52.4 % ) for the DFDBA group , and 1.27 mm ( 32.8 % ) for the D group . Defect resolution was 77.3 % for the DFDBA + TCN group , 77.9 % for the DFDBA group , and 63.8 % for the D group . The mean CADIA values were 5.04 for the DFDBA + TCN group , 6.79 for the DFDBA group and 2.78 for the D group . The CADIA values did not correlate with the clinical parameters . Although the grafted groups showed greater bone fill and defect resolution , there was no statistically significant difference in any of the clinical parameters between the treatment groups . This study suggests that there is no significant benefit from reconstituting the allograft with 50 mg/ml of tetracycline hydrochloride
In most respects , all membranes and enamel matrix derivative ( EMD ) delivered better outcomes , in the range of 1 to 2 mm , than open flap debridement .
The use of any barrier type or EMD configuration was found to yield more Clinical Attachment Level ( CAL ) gain than any open flap configuration .
GTR was confirmed to be superior to open flap debridement
In a 1998 review article , Laurell and colleagues performed a meta- analysis of relevant guided tissue regeneration ( GTR ) articles over the previous 20 years ( 1 ) .
The purpose of the present research was to exp and on that work , particularly search ing for trends discriminating between bioabsorbable and non-bioabsorbable barriers , as well as the use of enamel matrix derivative , with respect to interproximal bony defects .