Findings were mixed and showed various effects of cannabinoid administration on several aspects of sleep .
This paper review s the literature regarding the effects of cannabinoid administration on  sleep in humans .
Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study
Rationale Dronabinol ( Δ9tetrahydrocannabinol ) is approved for HIV-related anorexia , yet , little is known about its effects in HIV-positive marijuana smokers . HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects . Objectives Employing a within-subjects , double-blind , placebo-controlled design , we assessed the effects of repeated high-dose dronabinol in HIV-positive marijuana smokers taking antiretroviral medication . Methods Participants ( N = 7 ) , who smoked marijuana 4.2 ± 2.3 days/week , resided in a residential laboratory for two 16-day stays , receiving  dronabinol  ( 10 mg QID ) in one stay and placebo in the other . Efficacy was assessed with objective ly verified food intake and body weight . Tolerability was measured with sleep , subjective , and cognitive assessment s. For analyses , each inpatient stay was divided into two phases , days 1–8 and 9–16 ; we compared dronabinol ’s effects with placebo in each 8-day phase to investigate tolerance . Results Despite sustained increases in self-reported food cravings  , dronabinol only increased caloric intake in the initial 8 days of dosing . Similarly , sleep quality was improved only in the first 8 days of dosing  .  Dronabinol ’s mood-enhancing effects were sustained across the 16-day inpatient stay . Dronabinol was well tolerated , causing few negative subjective or cognitive effects . Conclusions In HIV-positive marijuana smokers , high dronabinol doses safely and effectively increased caloric intake . However , repeated high-dose dronabinol appeared to result in selective tolerance to these effects . These findings indicate that HIV-positive individuals who smoke marijuana may require higher dronabinol doses than are recommended by the FDA . Future research to establish optimal dosing regimens , and reduce the development of tolerance , is required
Findings were mixed and showed various effects of cannabinoid administration on several aspects of sleep .
This paper review s the literature regarding the effects of cannabinoid administration on  sleep in humans .