Summary Sedentary behaviour is associated with lower cognitive performance , although the attributable risk of sedentary time to all-cause dementia incidence is unclear .
Our systematic review provides evidence that limiting sedentary time and concomitantly engaging in regular moderate-to-vigorous physical activity may best promote healthy cognitive ageing
Aim The increasing rate of all-cause dementia worldwide and the lack of effective pharmaceutical treatments emphasise the value of lifestyle approaches as prevention strategies .
Emerging evidence suggests sedentary behaviour is associated with impaired cognitive function .
A better underst and ing of this association would significantly add to our knowledge of how to best promote healthy cognitive ageing .
Thus , we conducted a systematic review ascertaining the contribution of sedentary behaviour towards associated changes in cognitive function over the adult lifespan .
Apolipoprotein E ε4 magnifies lifestyle risks for dementia: a population-based study
The risk of dementia and Alzheimer 's disease ( AD ) probably results from an interaction between genetic and environmental factors . The aim of this study was to investigate the effects and putative interactions between the apoE ε4 allele and lifestyle related risk factors for dementia and AD . Participants of the Cardiovascular Risk Factors , Aging , and Dementia ( CAIDE ) study were derived from r and om , population -based sample s previously studied in 1972 , 1977 , 1982 or 1987 . After an average follow-up of 21 years , 1449 individuals ( 72.5 % ) aged 65–79 years were re-examined in 1998 . The apoE ε4 allele was an independent risk factor for dementia/AD even after adjustments for sociodemographic , lifestyle and vascular factors ( odds ratio [OR]= 2.83 , 95 % confidence interval [CI]ε1.61–4.97 ) . Physical inactivity , alcohol drinking and smoking increased the risk of dementia/AD particularly among the apoE ε4 carriers . Furthermore , low – moderate intake of polyunsaturated , and moderate – high intake of saturated fats were associated with an increased risk of dementia/AD more pronouncedly among apoE ε4 carriers . Composite effect of the lifestyle factors was particularly seen among the ε4 carriers ( OR = 11.42 , 95 % CI = 1.94–67.07 in the 4th quartile ) . Physical inactivity , dietary fat intake , alcohol drinking and smoking at midlife are associated with the risk of dementia and AD , especially among the apoE ε4 carriers . The apoE ε4 carriers may be more vulnerable to environmental factors , and thus , lifestyle interventions may greatly modify dementia risk particularly among the genetically susceptible individuals
Summary Sedentary behaviour is associated with lower cognitive performance , although the attributable risk of sedentary time to all-cause dementia incidence is unclear .
Our systematic review provides evidence that limiting sedentary time and concomitantly engaging in regular moderate-to-vigorous physical activity may best promote healthy cognitive ageing
Aim The increasing rate of all-cause dementia worldwide and the lack of effective pharmaceutical treatments emphasise the value of lifestyle approaches as prevention strategies .
Emerging evidence suggests sedentary behaviour is associated with impaired cognitive function .
A better underst and ing of this association would significantly add to our knowledge of how to best promote healthy cognitive ageing .
Thus , we conducted a systematic review ascertaining the contribution of sedentary behaviour towards associated changes in cognitive function over the adult lifespan .