Current evidence on the effects of palm oil consumption on biomarkers of glucose metabolism is poor and limited to only healthy participants .
We conclude that little or no additional benefit will be obtained by replacing palm oil with other oils rich in mono or polyunsaturated fatty acids for changes in glucose metabolism
INTRODUCTION Vegetable oil is an important source of fatty acids , and as palm oil being the highest consumed vegetable oil in many countries , its high saturated fatty acid content has led many concerns on cardiometabolic health .
Dietary fatty acids has also been linked to affect glucose metabolism and insulin sensitivity .
This systematic review is aim ed at critically evaluating the available evidence on the association of palm oil with the biomarkers of glucose metabolism as compared to other vegetable oils .
Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study
Summary Background Conflicting evidence exists regarding the association between saturated fatty acids ( SFAs ) and type 2 diabetes . In this longitudinal case-cohort study , we aim ed to investigate the prospect i ve associations between objective ly measured individual plasma phospholipid SFAs and incident type 2 diabetes in EPIC-InterAct participants . Methods The EPIC-InterAct case-cohort study includes 12 403 people with incident type 2 diabetes and a representative subcohort of 16 154 individuals who were selected from a cohort of 340 234 European participants with 3·99 million person-years of follow-up ( the EPIC study ) . Incident type 2 diabetes was ascertained until Dec 31 , 2007 , by a review of several sources of evidence . Gas chromatography was used to measure the distribution of fatty acids in plasma phospholipids ( mol% ) ; sample s from people with type 2 diabetes and subcohort participants were processed in a r and om order by centre , and laboratory staff were masked to participant characteristics . We estimated country-specific hazard ratios ( HRs ) for associations per SD of each SFA with incident type 2 diabetes using Prentice-weighted Cox regression , which is weighted for case-cohort sampling , and pooled our findings using r and om-effects meta- analysis . Findings SFAs accounted for 46 % of total plasma phospholipid fatty acids . In adjusted analyses , different individual SFAs were associated with incident type 2 diabetes in opposing directions . Even-chain SFAs that were measured ( 14:0 [ myristic acid ] , 16:0 [ palmitic acid ] , and 18:0 [ stearic acid ] ) were positively associated with incident type 2 diabetes ( HR [ 95 % CI ] per SD difference : myristic acid 1·15 [ 95 % CI 1·09–1·22 ] , palmitic acid 1·26 [ 1·15–1·37 ] , and stearic acid 1·06 [ 1·00–1·13 ] ) . By contrast , measured odd-chain SFAs ( 15:0 [ pentadecanoic acid ] and 17:0 [ heptadecanoic acid ] ) were inversely associated with incident type 2 diabetes ( HR [ 95 % CI ] per 1 SD difference : 0·79 [ 0·73–0·85 ] for pentadecanoic acid and 0·67 [ 0·63–0·71 ] for heptadecanoic acid ) , as were measured longer-chain SFAs ( 20:0 [ arachidic acid ] , 22:0 [ behenic acid ] , 23:0 [ tricosanoic acid ] , and 24:0 [ lignoceric acid ] ) , with HRs ranging from 0·72 to 0·81 ( 95 % CIs ranging between 0·61 and 0·92 ) . Our findings were robust to a range of sensitivity analyses . Interpretation Different individual plasma phospholipid SFAs were associated with incident type 2 diabetes in opposite directions , which suggests that SFAs are not homogeneous in their effects . Our findings emphasise the importance of the recognition of subtypes of these fatty acids . An improved underst and ing of differences in sources of individual SFAs from dietary intake versus endogenous metabolism is needed . Funding EU FP6 programme , Medical Research Council Epidemiology Unit , Medical Research Council Human Nutrition Research , and Cambridge Lipidomics Biomarker Research Initiative
Current evidence on the effects of palm oil consumption on biomarkers of glucose metabolism is poor and limited to only healthy participants .
We conclude that little or no additional benefit will be obtained by replacing palm oil with other oils rich in mono or polyunsaturated fatty acids for changes in glucose metabolism
INTRODUCTION Vegetable oil is an important source of fatty acids , and as palm oil being the highest consumed vegetable oil in many countries , its high saturated fatty acid content has led many concerns on cardiometabolic health .
Dietary fatty acids has also been linked to affect glucose metabolism and insulin sensitivity .
This systematic review is aim ed at critically evaluating the available evidence on the association of palm oil with the biomarkers of glucose metabolism as compared to other vegetable oils .