Probiotics intake in patients with MetS result ed in improvements in body mass index , blood pressure , glucose metabolism , and lipid profile in some studies .
Regarding inflammatory biomarkers , probiotics also positively affected the soluble vascular cell adhesion molecule 1 ( sVCAM-1 ) , interleukine-6 ( IL-6 ) , tumor necrosis factor α ( TNF-α ) , vascular endothelial growth factor ( VEGF ) , and thrombomodulin .
Despite the diversity of the published studies , the intake of probiotics for patients with MetS may offer a discrete improvement in some of the clinical characteristics of the MetS and a decrease in inflammatory biomarkers .
The aim of this systematic review is to evaluate whether the use of probiotics has any effect on the components of metabolic syndrome ( MetS ) before patients develop type 2 diabetes .
Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients - a randomized double-blind placebo-controlled pilot study
Background Gut lactobacilli can affect the metabolic functions of healthy humans . We tested whether a 1500 kcal/d diet supplemented with cheese containing the probiotic Lactobacillus plantarum TENSIA ( Deutsche Sammlung für Mikroorganismen , DSM 21380 ) could reduce some symptoms of metabolic syndrome in Russian adults with obesity and hypertension . Methods In this 3-week , r and omized , double-blind , placebo-controlled , parallel pilot study , 25 subjects ingested probiotic cheese and 15 ingested control cheese .  Fifty grams of each cheese provided 175 kcal of energy . Blood pressure ( BP ) , anthropometric characteristics , markers of liver and kidney function , metabolic indices ( plasma glucose , lipids , and cholesterol ) , and urine polyamines were measured . Counts of fecal lactobacilli and L. plantarum TENSIA were evaluated using molecular methods . The data were analyzed by t-test for independent sample s and Spearman ’s partial correlation analysis . Results The probiotic L. plantarum TENSIA was present in variable amounts ( 529.6 ± 232.5 gene copies ) in 16/25 ( 64 % ) study subjects . Body mass index ( BMI ) was significantly reduced ( p = 0.031 ) in the probiotic cheese group versus the control cheese group . The changes in BMI were closely associated with the water content of the body ( r = 0.570 , p = 0.0007 ) when adjusted for sex and age . Higher values of intestinal lactobacilli after probiotic cheese consumption were associated with higher BMI ( r = 0.383 , p = 0.0305 ) and urinary putrescine content ( r = 0.475 , p = 0.006 ) . In patients simultaneously treated with BP-lowering drugs , similar reductions of BP were observed in both groups . A positive association was detected between TENSIA colonization and the extent of change of morning diastolic BP ( r = 0.617 , p = 0.0248 ) and a trend toward lower values of morning systolic BP ( r = −0.527 , p = 0.0640 ) at the end of the study after adjusting for BMI , age , and sex . Conclusion In a pilot study of obese hypertensive patients , a hypocaloric diet supplemented with a probiotic cheese helps to reduce BMI and arterial BP values , recognized symptoms of metabolic syndrome . Trial registration Current Controlled Trials IS RCT
Probiotics intake in patients with MetS result ed in improvements in body mass index , blood pressure , glucose metabolism , and lipid profile in some studies .
Regarding inflammatory biomarkers , probiotics also positively affected the soluble vascular cell adhesion molecule 1 ( sVCAM-1 ) , interleukine-6 ( IL-6 ) , tumor necrosis factor α ( TNF-α ) , vascular endothelial growth factor ( VEGF ) , and thrombomodulin .
Despite the diversity of the published studies , the intake of probiotics for patients with MetS may offer a discrete improvement in some of the clinical characteristics of the MetS and a decrease in inflammatory biomarkers .
The aim of this systematic review is to evaluate whether the use of probiotics has any effect on the components of metabolic syndrome ( MetS ) before patients develop type 2 diabetes .