Fructose consumption did not significantly affect fasting glucose or insulin .
A priori subgroup analyses showed no evidence of effect modification on any end point .
Isocaloric exchange of fructose for other carbohydrate improves long-term glycemic control , as assessed by glycated blood proteins , without affecting insulin in people with diabetes .
OBJECTIVE The effect of fructose on cardiometabolic risk in humans is controversial .
We conducted a systematic review and meta- analysis of controlled feeding trials to clarify the effect of fructose on glycemic control in individuals with diabetes .
Fructose and insulin sensitivity in patients with type 2 diabetes.
The effect of dietary fructose ( 20 % of carbohydrate calories , 45 - 65 g day-1 for 4 weeks ) on glycaemic control , serum lipid , lipoprotein and apoprotein A-I and A-II concentrations and on insulin sensitivity was studied in 10 type 2 diabetic patients . The study was done in a r and omized , double-blind fashion with crystalline fructose or placebo administered evenly during 4 meals or snacks per day . The patients were hospitalized throughout the study periods . The fasting plasma glucose concentration decreased during the fructose ( from 10.7 + /- 1.4 mmol l-1 to 8.0 + /- 0.8 mmol l-1 , P < 0.02 ) and the control diet ( from 10.1 + /- 0.9 mmol l-1 to 8.0 + /- 0.7 mmol l-1 , P < 0.05 ) . The mean diurnal blood glucose concentration also fell both during the fructose ( from 10.8 + /- 0.5 mmol l-1 to 8.4 + /- 0.3 mmol l-1 , P < 0.001 ) and the control diet ( from 10.3 + /- 0.3 mmol l-1 to 8.8 + /- 0.9 mmol l-1 , P < 0.01 ) . The HbA1 concentration improved ( P < 0.02 ) only during the fructose diet . Insulin sensitivity increased by 34 % ( P < 0.05 ) during the fructose diet , but remained unchanged during the control period . Serum insulin , triglyceride , apoprotein A-I and A-II concentrations , body weight , blood pressure and blood lactate remained unchanged during both diets . In conclusion , substitution of moderate amounts of fructose for complex carbohydrates can improve glycaemic control and insulin sensitivity in patients with type 2 diabetes
Fructose consumption did not significantly affect fasting glucose or insulin .
A priori subgroup analyses showed no evidence of effect modification on any end point .
Isocaloric exchange of fructose for other carbohydrate improves long-term glycemic control , as assessed by glycated blood proteins , without affecting insulin in people with diabetes .
OBJECTIVE The effect of fructose on cardiometabolic risk in humans is controversial .
We conducted a systematic review and meta- analysis of controlled feeding trials to clarify the effect of fructose on glycemic control in individuals with diabetes .