Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .
Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study.
A growing body of evidence implicates a derangement of zinc homeostasis in mood disorders . In general , unipolar depression is connected with low blood zinc levels that are increased by effective antidepressant therapy . A placebo-controlled , double blind pilot study of zinc supplementation in antidepressant therapy was conducted in patients who fulfilled DSM IV criteria for major ( unipolar ) depression . Patients received zinc supplementation ( 6 patients ; 25 mg of  Zn2 + once daily ) or  placebo  ( 8 patients ) and were treated with st and ard antidepressant therapy ( tricyclic antidepressants , selective serotonin reuptake inhibitors ) . Hamilton Depression Rating Scale ( HDRS ) and Beck Depression Inventory ( BDI ) were used to assess efficacy of antidepressant therapy , and patients ' status was evaluated before the treatment and 2 , 6 and 12 weeks after its commencement . Antidepressant treatment significantly reduced HDRS scores by the 2nd week of treatment in both groups , and lowered BDI scores at the 6th week in zinc-treated group . Zinc supplementation significantly reduced scores in both measures after 6- and 12-week supplementation when compared with placebo treatment . This preliminary study is the first demonstration of the benefit of zinc supplementation in antidepressant therapy . The mechanism(s ) may be related to modulation of glutamatergic or immune systems by zinc ion
Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .