On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Bupropion versus methylphenidate in the treatment of attention-deficit hyperactivity disorder.
OBJECTIVE In the treatment of attention-deficit hyperactivity disorder ( ADHD ) , the efficacy of the tricyclic antidepressants and monoamine oxidase inhibitor antidepressants has been compared with that of both placebo and the stimulants ( methylpheni date and /or dextroamphetamine ) . However , the effectiveness of bupropion has been contrasted only with placebo . The primary aim of this study was to contrast the efficacy of bupropion with that of methylpheni date in the treatment of ADHD . METHOD A double-blind , crossover design was used in this study . After a 14-day medication washout period , 15 ADHD subjects ( 7 to 17 years old ) were r and omized to either methylpheni date or bupropion for 6 weeks , washed out for an additional 2 weeks , and then " crossed over " to the other drug . Methylpheni date was titrated to the maximum effective dose of 0.4 to 1.3 mg/kg per day ( mean 0.7 mg/kg per day ) and bupropion was titrated to an effective dose ranging from 1.4 to 5.7 mg/kg per day ( mean 3.3 mg/kg per day ) . RESULTS Both methylpheni date and bupropion produced significantly greater ( p < .001 ) and equivalent improvement on the Iowa-Conners Teacher 's Rating Scale according to both the subjects ' parents and teachers . The same pattern of improvement was also noted for improvement on the Clinical Global Impression Scale , Kagan 's Matching Familiar Figures Test , Continuous Performance Test , Children 's Depression Inventory , Children 's Manifest Anxiety Scale , and Rey Auditory-Verbal Learning Test . CONCLUSIONS In this double-blind , crossover trial , bupropion and methylpheni date were both effective and did not differ in their overall efficacy as treatments for ADHD
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .