Data from these sources do not support linkages between sugar consumption at normal levels within the human diet and various adverse metabolic and health-related effects
Abstract The relationship between sugar consumption and various health-related sequelas is controversial .
Some investigators have argued that excessive sugar consumption is associated with increased risk of obesity , coronary heart disease , diabetes ( T2D ) , metabolic syndrome , non-alcoholic fatty liver disease , and stimulation of reward pathways in the brain potentially causing excessive caloric consumption .
These concerns have influenced organizations such as the World Health Organization , the Scientific Advisory Committee on Nutrition in Engl and not to exceed 5 % of total energy and the Dietary Guidelines for Americans Advisory Committee 2015 to recommend upper limits of sugar consumption not to exceed 10 % of calories .
Data from many r and omized control trials ( RCTs ) do not support linkages between sugar consumption at normal levels within the human diet and various adverse metabolic and health-related effects .
Fructose and glucose are typically consumed together in roughly equal proportions from high-fructose corn syrup ( also known as isoglucose in Europe ) or sucrose .
The purpose of this review is to present data from recent RCTs and findings from recent systematic review s and meta-analyses related to sugar consumption and its putative health effects .
This review evaluates findings from recent r and omized controlled trials , systematic review s and meta-analyses into the relationship of sugar consumption and a range of health-related issues including energy-regulating hormones , obesity , cardiovascular disease , diabetes , and accumulation of liver fat and neurologic responses .
Functional magnetic resonance imaging of human hypothalamic responses to sweet taste and calories.
BACKGROUND Evidence exists that beverages do not trigger appropriate anticipatory physiologic responses , such as cephalic phase insulin release . Therefore , it is of interest to eluci date the food properties necessary for triggering adaptive responses . Previously , we found a prolonged dose-dependent decrease in the hypothalamic functional magnetic resonance imaging signal after ingestion of a glucose solution . OBJECTIVES The aims of the present study were to measure the effects of sweet taste and energy content on the hypothalamic response to glucose ingestion and to measure the concomitant changes in blood glucose and insulin concentrations . DESIGN Five healthy , normal-weight men participated in a r and omized crossover design trial . The subjects were scanned 4 times for 37 min on separate days with functional magnetic resonance imaging . After 7 min , they ingested 1 of the following 4 stimuli ( 300 mL of each ) : water ( control ) , a glucose solution , an aspartame ( sweet taste ) solution , or a maltodextrin ( nonsweet carbohydrate ) solution . RESULTS Glucose ingestion result ed in a prolonged and significant signal decrease in the upper hypothalamus ( P < 0.05 ) . Water , aspartame , and maltodextrin had no such effect . Glucose and maltodextrin ingestions result ed in similar increases in blood glucose and insulin concentrations . However , only glucose triggered an early rise in insulin concentrations . Aspartame did not trigger any insulin response . CONCLUSIONS Our findings suggest that both sweet taste and energy content are required for a hypothalamic response . The combination of sweet taste and energy content could be crucial in triggering adaptive responses to sweetened beverages
Data from these sources do not support linkages between sugar consumption at normal levels within the human diet and various adverse metabolic and health-related effects
Abstract The relationship between sugar consumption and various health-related sequelas is controversial .
Some investigators have argued that excessive sugar consumption is associated with increased risk of obesity , coronary heart disease , diabetes ( T2D ) , metabolic syndrome , non-alcoholic fatty liver disease , and stimulation of reward pathways in the brain potentially causing excessive caloric consumption .
These concerns have influenced organizations such as the World Health Organization , the Scientific Advisory Committee on Nutrition in Engl and not to exceed 5 % of total energy and the Dietary Guidelines for Americans Advisory Committee 2015 to recommend upper limits of sugar consumption not to exceed 10 % of calories .
Data from many r and omized control trials ( RCTs ) do not support linkages between sugar consumption at normal levels within the human diet and various adverse metabolic and health-related effects .
Fructose and glucose are typically consumed together in roughly equal proportions from high-fructose corn syrup ( also known as isoglucose in Europe ) or sucrose .
The purpose of this review is to present data from recent RCTs and findings from recent systematic review s and meta-analyses related to sugar consumption and its putative health effects .
This review evaluates findings from recent r and omized controlled trials , systematic review s and meta-analyses into the relationship of sugar consumption and a range of health-related issues including energy-regulating hormones , obesity , cardiovascular disease , diabetes , and accumulation of liver fat and neurologic responses .