Although , the meta- analysis conducted included a few number of studies , but has shown promising results on the effectiveness of N. sativa on glucose homeostasis and serum lipids .
BACKGROUND & OBJECTIVE ( S ) Global prevalence of type 2 diabetes ( T2D ) is very high and is currently growing alarmingly .
With respect to recent research ers ' attention to the potential role of herbal medicine in disease prevention and management , the present meta- analysis review investigates the effectiveness of Nigella sativa ( N. sativa ) , a popular herb , in T2D .
The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content
The antidiabetic effect of N. sativa seed ethanol extract ( NSE ) was assessed in Meriones shawi after development of diabetes . Meriones shawi were divided r and omly into four groups : normal control , diabetic control , diabetic treated with NSE ( 2 g eq plant/kg ) or with metformin ( 300 mg/kg ) positive control , both administered by daily intragastric gavage for 4 weeks . Glycaemia and body weight were evaluated weekly . At study 's end , an Oral Glucose Tolerance Test ( OGTT ) was performed to estimate insulin sensitivity . Upon sacrifice , plasma lipid profile , insulin , leptin , and adiponectin levels were assessed . ACC phosphorylation and Glut4 protein content were determined in liver and skeletal muscle . NSE animals showed a progressive normalization of glycaemia , albeit slower than that of metformin controls . Moreover , NSE increased insulinemia and HDL-cholesterol , compared to diabetic controls . Leptin and adiponectin were unchanged . NSE treatment decreased OGTT and tended to decrease liver and muscle triglyceride content .  NSE stimulated muscle and liver ACC phosphorylation and increased muscle Glut4 . These results confirm NSE 's previously reported hypoglycaemic and hypolipidemic activity . More significantly , our data demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation , a major component of the insulin-independent AMPK signaling pathway , and by enhancing muscle Glut4 expression
Although , the meta- analysis conducted included a few number of studies , but has shown promising results on the effectiveness of N. sativa on glucose homeostasis and serum lipids .
BACKGROUND & OBJECTIVE ( S ) Global prevalence of type 2 diabetes ( T2D ) is very high and is currently growing alarmingly .
With respect to recent research ers ' attention to the potential role of herbal medicine in disease prevention and management , the present meta- analysis review investigates the effectiveness of Nigella sativa ( N. sativa ) , a popular herb , in T2D .