RESULTS Following an extensive review of selected studies from the 201 articles , the studies indicate that each of the psychotropic medications review ed impact alpha , beta , delta and theta waves independently and differently from each other .
Additionally , certain medications , particularly haloperidol and valproic acid , have dissimilar results exemplified in all waveforms .
OBJECTIVES It is known that psychotropic medications have an impact on the readings found in Electroencephalogram ( EEG ) .
In the field of psychiatry , there are several psychotropics utilized by clinicians .
This review seeks to investigate all the available data for psychotropic drugs and their impact on EEG changes .
Clinical, Cognitive, and Neurophysiologic Correlates of Short-Term Treatment with Carbamazepine, Oxcarbazepine, and Levetiracetam in Healthy Volunteers
BACKGROUND The adverse effects of the antiepileptic drugs ( AEDs ) originally developed are well known , while those of the newer AEDs remain unclear . OBJECTIVE To investigate clinical , cognitive , and neurophysiologic effects of carbamazepine , oxcarbazepine , and levetiracetam in healthy volunteers . METHODS A double-blind crossover study was conducted in 10 volunteers . Eight-day treatment with carbamazepine , oxcarbazepine , levetiracetam , or placebo was administered in r and om order . Drug doses were titrated gradually to the daily target doses on day 7 : carbamazepine 800 mg , oxcarbazepine 1200 mg , and levetiracetam 1500 mg . At baseline and at the end of each treatment period , participants underwent cognitive and neurophysiologic assessment . A washout period of 14 days between treatment periods was conducted . RESULTS More adverse events were self-reported with carbamazepine ( 63 % ) than the other treatments ( oxcarbazepine 12 % , levetiracetam 20 % , placebo 5 % ; p < 0.001 between the 4 groups ) . Carbamazepine induced the greatest motor slowing ( p = 0.002 ) , followed by oxcarbazepine ( p = 0.01 ) . Levetiracetam left baseline motor speed unchanged . All AEDs increased attention span from baseline values as shown on the Stroop test . Quantitative electroencephalogram ( EEG ) analysis showed that carbamazepine significantly increased the delta – theta power and reduced the frequency of alpha rhythm ; oxcarbazepine induced smaller changes than carbamazepine . Levetiracetam did not change any EEG measurements . On color visually evoked potential ( VEP ) tests , carbamazepine induced a constant slowing of P1 latency , while oxcarbazepine induced changes only after the blue – black pattern . All color VEP measures for volunteers receiving levetiracetam were almost unchanged . CONCLUSIONS After short-term treatment in healthy volunteers , carbamazepine induced major clinical and neurophysiologic changes . Oxcarbazepine was better tolerated than carbamazepine . Levetiracetam interfered least with clinical and neurophysiologic test results
RESULTS Following an extensive review of selected studies from the 201 articles , the studies indicate that each of the psychotropic medications review ed impact alpha , beta , delta and theta waves independently and differently from each other .
Additionally , certain medications , particularly haloperidol and valproic acid , have dissimilar results exemplified in all waveforms .
OBJECTIVES It is known that psychotropic medications have an impact on the readings found in Electroencephalogram ( EEG ) .
In the field of psychiatry , there are several psychotropics utilized by clinicians .
This review seeks to investigate all the available data for psychotropic drugs and their impact on EEG changes .