Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .
A Double-blind Comparison Between Bupropion XL and Venlafaxine XR: Sexual Functioning, Antidepressant Efficacy, and Tolerability
Abstract : In this double-blind , multicenter study , bupropion XL , a norepinephrine-dopamine reuptake inhibitor , and venlafaxine XR , a serotonin-norepinephrine reuptake inhibitor , were compared with regard to sexual functioning , efficacy , and tolerability . A total of 348 sexually active adult out patients with depression were r and omized to receive bupropion XL ( titrated to a target dose of 300 - 450 mg/d ) or venlafaxine XR ( titrated to a target dose of 150 - 225 mg/d ) for 12 weeks . Total scores on the primary dependent variable , the Changes in Sexual Functioning Question naire ( self-report ) , increased for subjects receiving bupropion XL and decreased for those treated with venlafaxine XR ; the mean change scores differed significantly between groups from week 2 onward . Among subjects with normal pretreatment sexual functioning , Changes in Sexual Functioning Question naire total scores remained essentially unchanged for the bupropion XL group but were decreased significantly for the venlafaxine XR group ; mean change scores also differed between groups from week 2 onward . Although the therapies result ed in similar change on the 17-item Hamilton Depression Rating Scale , remission rates were significantly higher among those treated with bupropion XL ( 46 % ) versus venlafaxine XR ( 33 % ) ( odds ratio , 1.93 ; 95 % confidence interval , 1.07 - 3.46 ) . Aside from adverse effects of venlafaxine XR on sexual function , both treatments were reasonably well tolerated . In conclusion , in this patient population ( ie , relatively young , sexually active out patients ) , bupropion XL was at least as effective as venlafaxine XR and had a significantly more favorable sexual side effect profile
Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .