The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation .
Conclusion : This meta- analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels
ABSTRACT Objective : The aim of this systematic review and meta- analysis was to determine and clarify the impact of curcuminoids on  serum lipid levels .
Atherogenic Dyslipidemia and Residual Cardiovascular Risk in Statin-Treated Patients
Background and Purpose — Treatment with statins reduces the rate of cardiovascular events in high-risk patients , but residual risk persists . At least part of that risk may be attributable to atherogenic dyslipidemia characterized by low high-density lipoprotein cholesterol ( ⩽40 mg/dL ) and high triglycerides ( triglycerides ≥150 mg/dL ) . Methods — We studied subjects with stroke or transient ischemic attack in the Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin With Terutroban  in Patients With a History of Ischemic Stroke or Transient Ischemic Attack ( PERFORM ; n=19 100 ) and Stroke Prevention by Aggressive Reduction in Cholesterol Levels ( SPARCL ; n=4731 ) trials who were treated with a statin and who had high-density lipoprotein cholesterol and triglycerides measurements 3 months after r and omization ( n=10 498 and 2900 , respectively ) . The primary outcome measure for this exploratory analysis was the occurrence of major cardiovascular events ( nonfatal myocardial infa rct ion , nonfatal stroke , or cardiovascular death ) . We also performed a time-varying analysis to account for all available high-density lipoprotein cholesterol and triglyceride measurements . Results — A total of 10 % of subjects in PERFORM and 9 % in SPARCL had atherogenic dyslipidemia after ≥3 months on start statin therapy . After a follow-up of 2.3 years ( PERFORM ) and 4.9 years ( SPARCL ) , a major cardiovascular event occurred in 1123 and 485 patients in the 2 trials , respectively . The risk of major cardiovascular events was higher in subjects with versus those without atherogenic dyslipidemia in both PERFORM ( hazard ratio , 1.36 ; 95 % confidence interval , 1.14–1.63 ) and SPARCL ( hazard ratio , 1.40 ; 95 % confidence interval , 1.06–1.85 ) . The association was attenuated after multivariable adjustment ( hazard ratio , 1.23 ; 95 % confidence interval , 1.03–1.48 in PERFORM and hazard ratio , 1.24 ; 95 % confidence interval , 0.93–1.65 in SPARCL ) . Time-varying analysis confirmed these findings . Conclusions — The presence of atherogenic dyslipidemia was associated with higher residual cardiovascular risk in PERFORM and SPARCL subjects with stroke or transient ischemic attack receiving statin therapy . Specific therapeutic interventions should now be trialed to address this residual risk
The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation .
Conclusion : This meta- analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels
ABSTRACT Objective : The aim of this systematic review and meta- analysis was to determine and clarify the impact of curcuminoids on  serum lipid levels .