R and omized controlled trials found a positive correlation for SB with BMI , neck circumference , fat mass , HbA1C , cholesterol and insulin levels , cohort studies additionally for WC , leptin , C-peptide , ApoA1 and Low density lipoprotein and a negative correlation for HDL .
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin .
OBJECTIVE Pathomechanisms of sedentary behaviour ( SB ) are unclear .
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults .
Effect of physical activity level on biomarkers of inflammation and insulin resistance over 5 years in outpatients with coronary heart disease (from the Heart and Soul Study).
Higher levels of physical activity are associated with lower rates of coronary heart disease ( CHD ) . Previous studies have suggested that this is due partly to lower levels of inflammation and insulin resistance . The aim of this study was to determine whether physical activity level was associated with inflammation or insulin resistance during a 5-year period in out patients with known CHD . A total of 656 participants from the Heart and Soul Study , a prospect i ve cohort study of out patients with documented CHD , were evaluated .  Self-reported physical activity frequency was assessed at baseline and after 5 years of follow-up . Participants were classified as low versus high activity at each visit , yielding 4 physical activity groups : stable low activity , decreasing activity ( high at baseline to low at year 5 ) , increasing activity ( low at baseline to high at year 5 ) , and stable high activity . Year 5 markers of inflammation ( C-reactive protein [ CRP ] , interleukin-6 , and fibrinogen ) and insulin resistance ( insulin , glucose , and glycated hemoglobin ) were compared across the 4 activity groups . After 5 years of follow-up , higher activity was associated with lower mean levels of all biomarkers . In the fully adjusted regression models , CRP , interleukin-6 , and glucose remained independently associated with physical activity frequency ( log CRP , p for trend across activity groups = 0.03 ; log interleukin-6 , p for trend = 0.01 ; log glucose , p for trend = 0.003 ) . Subjects with stable high activity typically had the lowest levels of biomarkers . In conclusion , in this novel population of out patients with known CHD followed for 5 years , higher physical activity frequency was independently associated with lower levels of CRP , interleukin-6 , and glucose
R and omized controlled trials found a positive correlation for SB with BMI , neck circumference , fat mass , HbA1C , cholesterol and insulin levels , cohort studies additionally for WC , leptin , C-peptide , ApoA1 and Low density lipoprotein and a negative correlation for HDL .
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin .
OBJECTIVE Pathomechanisms of sedentary behaviour ( SB ) are unclear .
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults .