Sensitivity analysis showed that overall estimates were not affected by elimination of any study .
We did not observe any evidence regarding publication bias .
In conclusion , vitamin K supplementation had no signiﬁcant effect on glycemic control in healthy subjects .
Type 2 diabetes mellitus ( T2DM ) is one of the most important public health issues .
Vitamin K supplementation might have favorable effect on risk factors of T2DM .
The aim of this study was to perform a systematic review and meta- analysis of interventional studies to examine the effect of vitamin K supplementation on glycemic indices .
Effect of Vitamin K Supplementation on Insulin Resistance in Older Men and Women
OBJECTIVE —Vitamin K has a potentially beneficial role in insulin resistance , but evidence is limited in humans . We tested the hypothesis that vitamin K supplementation for 36 months will improve insulin resistance in older men and women . RESEARCH DESIGN AND METHODS —This was an ancillary study of a 36-month , r and omized , double-blind , controlled trial design ed to assess the impact of supplementation with 500 μg/day phylloquinone on bone loss . Study participants were older nondiabetic men and women ( n = 355 ; aged 60–80 years ; 60 % women ) . The primary outcome of this study was insulin resistance as measured by homeostasis model assessment ( HOMA-IR ) at 36 months . Fasting plasma insulin and glucose were examined as the secondary outcomes . RESULTS —The effect of 36-month vitamin K supplementation  on HOMA-IR differed by sex ( sex × treatment interaction P = 0.02 ) . HOMA-IR was statistically significantly lower at the 36-month visit among men in the supplement group versus the men in the control group ( P = 0.01 ) after adjustment for baseline HOMA-IR , BMI , and body weight change . There were no statistically significant differences in outcome measures between intervention groups in women . CONCLUSIONS —Vitamin K supplementation for 36 months at doses attainable in the diet may reduce progression of insulin resistance in older men
Sensitivity analysis showed that overall estimates were not affected by elimination of any study .
We did not observe any evidence regarding publication bias .
In conclusion , vitamin K supplementation had no signiﬁcant effect on glycemic control in healthy subjects .
Type 2 diabetes mellitus ( T2DM ) is one of the most important public health issues .
Vitamin K supplementation might have favorable effect on risk factors of T2DM .
The aim of this study was to perform a systematic review and meta- analysis of interventional studies to examine the effect of vitamin K supplementation on glycemic indices .