There is no evidence of effectiveness in the alleviation of  menopausal symptoms with the use of phytoestrogen treatments
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone replacement therapy has traditionally been used as a very effective treatment but concerns over increased risks of some chronic diseases have markedly increased the interest of women in alternatives .
Some of the most popular of these are treatments based on foods or supplements enriched with phytoestrogens , plant-derived chemicals that have oestrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of foods and supplements based on high levels of phytoestrogens for reducing hot flushes and night sweats in postmenopausal women .
Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study.
OBJECTIVE The aim of this study was to evaluate the effects of isoflavone on the climacteric symptoms ( Kupperman Menopausal index ) , vaginal pH , vaginal cytology ( vaginal maturation index ) and endometrium ( evaluated by ultrasound and biopsy ) in postmenopausal women . METHODS It was a single-center , 6-month , r and omized , double-blind , estrogen-controlled trial . Seventy-nine women were r and omly assigned to one of the two treatment groups : isoflavone ( n=40 ) : 300 mg of the st and ardized soy extract with a medium dose of 120 mg isoflavones/day as glycoside and aglycone ( 60 mg twice a day ) , or estrogen ( n=39 ) : one capsule of 0.625 mg conjugated equine estrogens and other capsule with glucose 0.625 mg ( placebo ) . RESULTS After treatment , there was a decrease in the symptomatology in both estrogen and isoflavone groups . There was a significant decrease in vaginal pH , an increase in superficial vaginal cells and endometrium proliferation after 3 and 6 months of treatment in the estrogen group , but no differences were observed in the isoflavone group for these variables . CONCLUSIONS We concluded that the daily st and ardized soy extract with 120 mg isoflavones ' effect on symptoms was similar to that from estrogen . Soy isoflavone has no effect on endometrium and vaginal mucosa during the treatment
There is no evidence of effectiveness in the alleviation of  menopausal symptoms with the use of phytoestrogen treatments
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone replacement therapy has traditionally been used as a very effective treatment but concerns over increased risks of some chronic diseases have markedly increased the interest of women in alternatives .
Some of the most popular of these are treatments based on foods or supplements enriched with phytoestrogens , plant-derived chemicals that have oestrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of foods and supplements based on high levels of phytoestrogens for reducing hot flushes and night sweats in postmenopausal women .