In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .
Primary flap closure combined with Emdogain alone or Emdogain and Cerasorb in the treatment of intra-bony defects.
OBJECTIVES To compare clinical outcomes of three different modalities of treatment for deep intra-bony defects . MATERIAL AND METHODS Fifty-six patients were paralleled for clinical parameters and r and omly assigned to treatment . They displayed one angular defect each with an intra-bony component > or =3 mm , probing pocket depth ( PPD ) and probing attachment level ( PAL )  > or = 7 mm , and plaque index ( PI ) < 1 . Nineteen defects were treated , respectively , with enamel matrix derivative (EMD)+tricalcium phosphate ( TCP ) or EMD alone and 18 defects with modified Widman flap ( MWF ) . Primary flap closure was used in all three groups . PI , gingival index , bleeding on probing , PPD , PAL , and recession ( REC ) were measured before and 12 months after treatment . RESULTS Treatment with EMD alone yielded a 3.9+/-1.3 mm PPD decrease and a 3.7+/-1.0 mm PAL gain ( p<0.001 ) , whereas EMD+beta-TCP produced a 4.1+/-1.2 mm PPD reduction and a 4.0+/-1.0 mm PAL gain ( p<0.001 ) . These outcome parameters did not differ between the two groups . REC increased by 0.7+/-1.3 mm . After MWF treatment , attachment gain was 2.1+/-1.4 mm ( p<0.001 ) and PPD reduction was 3.8+/-1.8 mm , whereas REC increased by 1.5+/-0.7 mm ( p=0.042 versus EMD ) . CONCLUSION Both EMD treatments showed similar clinical effects , with significant PAL gain and a significantly lower REC increase in comparison with MWF treatment
In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .