In summary , the current meta- analysis demonstrated that melatonin supplementation  significantly decreased SBP and DBP in patients with metabolic disorders .
The current systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to evaluate the potential effect of melatonin supplementation on  blood pressure in patients with metabolic disorders .
Myocardial ischemia and autonomic activity in dippers and non-dippers with coronary artery disease: assessment of normotensive and hypertensive patients.
OBJECTIVES The aim of this study was to assess the relations between the circadian variations of blood pressure ( BP ) and the pattern of ischemia and autonomic activity in normotensive and hypertensive patients with coronary artery disease ( CAD ) . PATIENTS AND METHODS On the basis of the results of ambulatory BP monitoring , 115 patients with stable CAD were divided into Group 1 ( with arterial hypertension ) and Group 2 ( normotensives ) . Groups were subdivided into dippers and non-dippers . Holter monitoring was performed to assess the occurrence and circadian pattern of ischemic episodes . Time domain and frequency domain HRV analyses were performed to evaluate the autonomic activity . RESULTS The total number of ischemic episodes was similar in dippers and non-dippers . Non-dippers had a greater number of silent episodes and a different circadian pattern of ischemia with more night episodes . Among the time-domain HRV parameters , only SDNN was similar in dippers and non-dippers . Non-dippers had lower pNN50 and rMSSD-the parameters expressing parasympathetic activity . Differences between diurnal and nocturnal results of spectral HRV analysis were observed in dipper patients only . They presented an elevation of HF power and a decline of LF power at night . All differences between dippers and non-dippers were of similar significance in both hypertensives and normotensives . CONCLUSIONS A lack of a nocturnal fall in BP is present in normotensive and hypertensive patients with CAD . Non-dippers with CAD had silent and nighttime ischemia more often . They also had an abnormal pattern of autonomic activity with higher sympathetic and lower parasympathetic modulation
In summary , the current meta- analysis demonstrated that melatonin supplementation  significantly decreased SBP and DBP in patients with metabolic disorders .
The current systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to evaluate the potential effect of melatonin supplementation on  blood pressure in patients with metabolic disorders .