Cemented and uncemented tibial components had different migration patterns .
For cemented tibial components there was no difference in migration between all-poly and metal-backed components , between mobile bearing and fixed bearing , between cruciate retaining and posterior stabilized .
Furthermore , no difference existed between TKR measured with model-based RSA or marker-based RSA methods .
For uncemented TKR there was some variation in migration with the highest migration for uncoated TKR .
Interpretation - The results from this meta- analysis on  RSA migration of TKR  are in line with both the survival analyses results from joint registries of these TKRs as well as revision rates results from meta-analyses , thus providing further proof for the association between early migration and late revision for loosening .
Purpose - We performed a systematic review and meta-analyses to evaluate the early and long-term migration patterns of  tibial components of TKR of all known RSA studies .
Celecoxib does not appear to affect prosthesis fixation in total knee replacement
Background and purpose After joint replacement , a repair process starts at the interface between bone and cement . If this process is disturbed , the prosthesis may never become rigidly fixed to the bone , leading to migration— and with time , loosening . Cox-2 inhibitors are widely used as postoperative analgesics , and have adverse effects on bone healing . This could tamper prosthesis fixation . We investigated whether celecoxib , a selective Cox-2 inhibitor , increases prosthesis migration in total knee replacement ( TKR ) . Methods 50 patients were r and omized to either placebo or celecoxib treatment , 200 mg twice daily , for 3 weeks after TKR  ( NexGen ; Zimmer ) . Maximum total point motion ( MTPM ) of the tibial component was measured after 2 years using radiostereometric analysis ( RSA ) . In addition , range of motion , pain , and , subjective outcome were evaluated . Results No differences in prosthesis migration , pain scores , range of motion , and subjective outcome were found after 2 years . Confidence intervals were narrow . Interpretation It is unlikely that Celecoxib increases the risk of loosening , and it may be used safely in conjunction with TKR
Cemented and uncemented tibial components had different migration patterns .
For cemented tibial components there was no difference in migration between all-poly and metal-backed components , between mobile bearing and fixed bearing , between cruciate retaining and posterior stabilized .
Furthermore , no difference existed between TKR measured with model-based RSA or marker-based RSA methods .
For uncemented TKR there was some variation in migration with the highest migration for uncoated TKR .
Interpretation - The results from this meta- analysis on  RSA migration of TKR  are in line with both the survival analyses results from joint registries of these TKRs as well as revision rates results from meta-analyses , thus providing further proof for the association between early migration and late revision for loosening .
Purpose - We performed a systematic review and meta-analyses to evaluate the early and long-term migration patterns of  tibial components of TKR of all known RSA studies .