The review established the paucity of high quality evidence investigating the efficacy of psychotherapy combined with benzodiazepines for panic disorder .
Currently , there is inadequate evidence to assess the clinical effects of psychotherapy combined with benzodiazepines for patients who are diagnosed with panic disorder
BACKGROUND The efficacy of combining psychotherapy and benzodiazepines for panic disorder is unclear , despite widespread use .
OBJECTIVES To examine the efficacy of the combination compared with either treatment alone .
Lactate-induced anxiety after imipramine and diazepam treatment.
To examine the effect of treatment on lactate-induced anxiety in a controlled study , we infused 44 panic disorder patients with lactate and placebo before and after eight weeks of double-blind treatment with imipramine , diazepam , or placebo . During treatment , both imipramine and diazepam groups improved more than the placebo group . After treatment , patients in both the imipramine and diazepam groups had significantly less anxiety than the placebo patients when reinfused with lactate . In addition , imipramine decreased posttreatment panic attack frequency and diazepam decreased the perceived severity of posttreatment lactate-induced panic attacks . This study demonstrates that diazepam , like imipramine , is an effective treatment for panic disorder , and that both imipramine and diazepam blunt lactate-induced anxiety in a placebo controlled study
The review established the paucity of high quality evidence investigating the efficacy of psychotherapy combined with benzodiazepines for panic disorder .
Currently , there is inadequate evidence to assess the clinical effects of psychotherapy combined with benzodiazepines for patients who are diagnosed with panic disorder
BACKGROUND The efficacy of combining psychotherapy and benzodiazepines for panic disorder is unclear , despite widespread use .
OBJECTIVES To examine the efficacy of the combination compared with either treatment alone .