Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .
Helicobacter pylori gastritis and non-ulcer dyspepsia in childhood. Efficacy of one-week triple antimicrobial therapy in eradicating the organism.
Efficacy of one-week triple antimicrobial therapy ( bismuth , tinidazole , amoxicillin ) as compared to the same drug combination given for 4 weeks was assessed in children with Helicobacter pylori ( H. pylori ) gastritis and non-ulcer dyspepsia . Twenty-six patients ( group A ) and 30 ( group B ) had one-week and four-week schedule , respectively . Eradication ( absence of organism at endoscopy at least 1 month after ending treatment ) was achieved in 84.6 % of group A ( 22 ) and 83.3 % of group B ( 25 ) , with marked reduction of histological gastritis score in both groups . Among patients with eradicated H. pylori , symptoms improved significantly in 14 and 16 patients of group A and B , respectively , but were still present in 17 ( 8 group A , 9 group B ) . The latter showed gastroparesis and abnormal gastro-oesophageal reflux at a subsequent diagnostic work-up and improved with prokinetic therapy . In 3 patients of group A and 3 of group B , symptoms improved despite persistence of bacterium into the stomach . Finally , in 3 cases ( 1 group A , 2 group B ) both symptoms and H. pylori infection were unchanged . At 6 month follow-up , symptoms were present in 7 patients ( 3 group A , 4 group B ) : 6 of them ( 3 group A , 3 group B ) showed H. pylori gastritis at endoscopy . We conclude that in children with dyspepsia and H. pylori gastritis one-week triple antimicrobial schedule is effective in eradicating bacterium ; however , detection of H. pylori gastritis in dyspeptic children does not invariably indicate a pathogenic role of the organism in these patients
Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .