The benefits of antioxidants or DHA/EPA supplementation for CF , although observed in some studies , are not consistent enough to recommend routine use of these supplements .
Antioxidant micronutrients and essential fatty acids supplementation intake appears to have a protective effect in some diseases such as cardiovascular disease , cancer , and asthma .
The aim of this study was to perform a systematic review to evaluate the effects of these nutrients on nutritional and clinical outcomes of patients with cystic fibrosis ( CF ) .
This is a systematic review of r and omized clinical trials ( RCTs ) in CF .
Effect of Oral Lipid Matrix Supplement on Fat Absorption in Cystic Fibrosis: A Randomized Placebo-Controlled Trial
ABSTRACT Pancreatic enzyme therapy does not normalize dietary fat absorption in patients with cystic fibrosis and pancreatic insufficiency . Efficacy of LYM-X-SORB ( LXS ) , an easily absorbable lipid matrix that enhances fat absorption , was evaluated in a 12-month r and omized , double-blinded , placebo-controlled trial with plasma fatty acids ( FA ) and coefficient of fat absorption ( CFA ) outcomes . A total of 110 subjects ( age 10.4 ± 3.0 years ) were r and omized . Total FA increased with LXS at 3 and 12 months ( + 1.58 , + 1.14 mmol/L ) and not with placebo ( P = 0.046 ) . With LXS  , linoleic acid ( LA ) increased at 3 and 12 months ( + 298 , + 175 nmol/mL , P ⩽ 0.046 ) , with a 6 % increase in CFA ( P < 0.01 ) . LA increase was significant in LXS versus placebo ( 445 vs 42 nmol/mL , P = 0.038 ) . Increased FA and LA predicted increased body mass index Z scores . In summary , the LXS  treatment improved dietary fat absorption compared with placebo as indicated by plasma FA and LA and was associated with better growth status
The benefits of antioxidants or DHA/EPA supplementation for CF , although observed in some studies , are not consistent enough to recommend routine use of these supplements .
Antioxidant micronutrients and essential fatty acids supplementation intake appears to have a protective effect in some diseases such as cardiovascular disease , cancer , and asthma .
The aim of this study was to perform a systematic review to evaluate the effects of these nutrients on nutritional and clinical outcomes of patients with cystic fibrosis ( CF ) .
This is a systematic review of r and omized clinical trials ( RCTs ) in CF .