Although pain was a common criterion for nonresponse and appendectomy , analgesic regimens were poorly described .
BACKGROUND Meta-analyses and a recent guideline acknowledge that conservative management of uncomplicated appendicitis with antibiotics can be successful for patients who wish to avoid surgery .
However , guidance as to specific management does not exist .
High failure rate of nonoperative management of acute appendicitis with an appendicolith in children.
BACKGROUND The purpose of this study was to investigate the feasibility of  nonoperative management of acute appendicitis in children with an appendicolith identified on preoperative imaging . STUDY DESIGN We performed a prospect i ve nonr and omized trial of nonoperative management of uncomplicated acute appendicitis with an appendicolith in children aged 7 to 17years . The primary outcome was the failure rate of nonoperative management , defined as having undergone an appendectomy . Early termination was set to occur if the lower limit of the 95 % confidence interval of the failure rate was greater than 20 % at 30days or 30 % at 1year . RESULTS Recruitment for this study was halted after enrollment of 14 patients ( N=5 nonoperative ; N=9 surgery ) . The failure rate of nonoperative management was 60 % ( 3/5 ) at a median follow-up of 4.7months ( IQR 1.0 - 7.6 ) with a 95 % CI of 23%-88 % . None of the three patients that failed nonoperative management had complicated appendicitis at the time of appendectomy , while six out of nine patients who chose surgery had complicated appendicitis ( 0/3 vs. 6/9 , p=0.18 ) . The trial was stopped for concerns over patient safety . CONCLUSIONS Nonoperative management of acute appendicitis with an appendicolith in children result ed in an unacceptably high failure rate
Although pain was a common criterion for nonresponse and appendectomy , analgesic regimens were poorly described .
BACKGROUND Meta-analyses and a recent guideline acknowledge that conservative management of uncomplicated appendicitis with antibiotics can be successful for patients who wish to avoid surgery .
However , guidance as to specific management does not exist .