LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
The use of self-measured blood pressure determinations in assessing dynamics of drug compliance in a study with amlodipine once a day, morning versus evening
Objective : To test whether the time of administration influences the therapeutic response to a calcium antagonist taken once a day . Also , the dynamics of drug compliance and its impact on blood pressure control were investigated Design : Twenty out patients with mild-to-moderate hypertension were included in a r and omized , placebo-controlled open study . In a crossover design , all of the patients received 5 mg amlodipine , either in the morning or in the evening , during two consecutive 4-week treatment periods Methods : Blood pressure was taken by casual measurement , ambulatory 24-h monitoring ( SpaceLabs 90202 ) and self-measurement at home , performed with a semi-automatic oscillometric device during the whole study period . Compliance was assessed using the Medication-Event-Monitoring System ( MEMS ) Results : Neither casual nor ambulatory day- or night-time readings detected a significant difference between morning and evening administration . However , self-measurement documented significantly greater blood pressure reductions for morning than for evening administration . The MEMS showed different compliance on the days of ambulatory monitoring ( 100 % with both drug regimens ) compared with the whole treatment period . The number of days with missed medication was thus significantly higher for the evening dosing regimen . The difference in self-measured blood pressure between the two regimens was lost if the days with missed medication were removed from the statistical analysis Conclusions : Time of once-a-day amlodipine administration does not influence its efficacy for 24-h blood pressure control . Furthermore , the use of self-measurement and the MEMS may provide useful additional information on the pharmacodynamic impact of different dosing patterns in hypertensive
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .