Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .
Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers.
AIM The aim of the present study was to examine the pharmacokinetics of racemic alpha-lipoic acid in twelve healthy volunteers following single oral administration of 200 and 600 mg ( Thioctacid 200 film tablets )  . SUBJECTS , MATERIAL AND METHODS Each film tablet contained 200 mg of alpha-lipoic acid . In addition , an injection solution containing 200 mg of alpha-lipoic acid was administered . Plasma concentrations of alpha-lipoic acid were determined using a vali date d reversed-phase HPLC method with electrochemical detection having a lower limit of quantitation of 1 ng/ml . The areas under curve ( AUC ) were 46.82 + /- 21.46 and 157.97 + /- 35.05 microg x min/ml for the oral and intravenous administration of 200 mg , respectively . RESULTS The AUC following oral administration of 600 mg was 157.83 + /- 35.82 microg x min/ml . The difference in mean t(1/2 ) for the two oral doses and the i.v . dose ( in the range of 25.3 - 32.7 min ) was not statistically significant . CONCLUSION The lack of a significant difference between values for apparent total plasma clearance for the 200 and 600 mg doses indicates non-saturable kinetics of alpha-lipoic acid in healthy volunteers in this dose range . The absolute bioavailability after the 200 mg dose was 29.1 + /- 10.3 %
Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .