Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .
Impact of Roux-en-Y gastric bypass on lipid and inflammatory profiles.
OBJECTIVE To evaluate the behavior of acute phase proteins and lipid profile in patients undergoing Roux-en-Y gastric bypass .  METHODS We conducted a prospect i ve study , consisting of three moments : M1 - preoperative ( 24 hours before surgery ) ; M2 - 30 days after surgery ; and M3 - 180 days after surgery . We carried measured height and BMI , as well as determined the concentrations of acute phase proteins ( C-reactive protein ( CRP ) , albumin and Alpha-1-acid glycoprotein ) and total cholesterol , LDL-c , HDL-c and triacylglycerol . RESULTS participants comprised 25 individuals , with a mean age of 39.28 ± 8.07 , 72 % female . At all times of the study there was statistically significant difference as for weight loss and BMI . We found a significant decrease in CRP concentrations between the moments M1 and M3 ( p = 0.041 ) and between M2 and M3 ( p = 0.018 ) . There was decrease in Alpha-1-GA concentrations between M1 and M2 ( p = 0.023 ) and between M1 and M3 ( p = 0.028 ) . The albumin values increased , but did not differ between times . Total cholesterol and triacylglycerol decreased significantly ay all times . LDL-c concentrations decreased and differed between M1 and M2 ( p = 0.001 ) and between M1 and M3 ( p = 0.001 ) . HDL-c values increased , however only differing between M1 and M2 ( p = 0.050 ) . CONCLUSION Roux-en-Y gastric bypass promoted a decrease in plasma concentrations of CRP and Alpha-1-acid glycoprotein , improving lipid and inflammatory profiles
Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .