Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Vitamin D3 Loading Is Superior to Conventional Supplementation After Weight Loss Surgery in Vitamin D-Deficient Morbidly Obese Patients: a Double-Blind Randomized Placebo-Controlled Trial
Background Bariatric patients often suffer from vitamin D deficiency ( VDD ) , and both , morbid obesity and VDD , are related to non-alcoholic fatty liver disease . However , limited data are available regarding best strategies for treating VDD , particularly , in bariatric patients undergoing omega-loop gastric bypass ( OLGB ) . Therefore , we examined the efficacy and safety of a forced vitamin D dosing regimen and intervention effects in liver fibrotic patients . Methods In this double-blind , r and omized , placebo-controlled trial , 50 vitamin D-deficient patients undergoing OLGB were r and omly assigned to receive , in the first month postoperatively , oral vitamin D3 ( ≤3 doses of 100,000 IU ; intervention group ) or placebo as loading dose ( control group ) with subsequent maintenance dose ( 3420 IU/day ) in both groups until 6-month visit . Results Compared with control group , higher increase of 25(OH)D ( 67.9 ( 21.1 ) vs. 55.7 nmol/L ( 21.1 ) ; p = 0.049 ) with lower prevalence of secondary hyperparathyroidism ( 10 vs. 24 % ; p = 0.045 ) was observed in intervention group . No ( serious ) adverse events related to study medication were found . The loading dose regimen was more effective in increasing 25(OH)D in patients with significant liver fibrosis while this was not the case for conventional supplementation ( placebo with maintenance dose ) ( 71.5 ( 20.5 ) vs. 22.5 nmol/L ( 13.8 ) ; p = 0.022 ; n = 14 ) . Conclusions Our findings indicate that a high vitamin D3 loading dose , in the first month postoperatively , with subsequent maintenance dose is effective and safe in achieving higher vitamin D concentrations in OLGB patients . Unexpectedly , it is more effective in patients with significant liver fibrosis which is of potentially high clinical relevance and requires further investigation
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .