RESULTS Increased TFA intake did not result in significant changes in glucose or insulin concentrations .
Our analysis also showed the absence of publication bias and any dose-response relations between the ES and TFA intake .
Increased TFA intake does not result in changes in glucose , insulin , or triglyceride concentrations but leads to an increase in total and LDL-cholesterol and a decrease in HDL-cholesterol concentrations .
There is no evidence to support a potential benefit of the reduction of dietary TFA intake on glucose homeostasis
BACKGROUND Although evidence from cohort studies has suggested that trans fatty acid ( TFA ) consumption may be associated with insulin resistance and diabetes , r and omized placebo-controlled trials ( RCTs ) have yielded conflicting results .
OBJECTIVE In a meta- analysis , we combined all available RCTs that examined the role of  TFA intake  on  glucose homeostasis .
Dietary patterns and diabetes incidence in the Melbourne Collaborative Cohort Study.
The authors investigated the association of dietary patterns and  type 2 diabetes  in a 4-year prospect i ve study of 36,787 adults in the Melbourne Collaborative Cohort Study ( 1990 - 1994 ) . A total of 31,641 ( 86 % ) participants completed follow-up , and 365 cases were identified . Four factors with eigenvalues of greater than 2 were identified using the principal factor method with 124 foods/beverages , followed by orthogonal rotation . Variables with factor loadings having absolute values of 0.3 or greater were used in interpreting the factors . Odds ratios for diabetes incidence across quintiles of factor scores were computed by use of logistic regression , adjusting for age , energy intake , family history of diabetes , country of birth , and other factor scores . Factor 1 , characterized by olive oil , salad vegetables , and legumes and by avoidance of sweet bakery items , margarine , and tea , was associated with country of birth but not with diabetes . Factor 2 , characterized by salad and cooked vegetables , was inversely associated with diabetes . Factor 3 , characterized by meats and fatty foods , was associated with increased diabetes risk . A range of fruits loaded strongly on factor 4 , which showed little association with diabetes . Avoidance of a dietary pattern including meats and fatty foods , as well as adherence to a pattern including salad and cooked vegetables , is recommended
RESULTS Increased TFA intake did not result in significant changes in glucose or insulin concentrations .
Our analysis also showed the absence of publication bias and any dose-response relations between the ES and TFA intake .
Increased TFA intake does not result in changes in glucose , insulin , or triglyceride concentrations but leads to an increase in total and LDL-cholesterol and a decrease in HDL-cholesterol concentrations .
There is no evidence to support a potential benefit of the reduction of dietary TFA intake on glucose homeostasis
BACKGROUND Although evidence from cohort studies has suggested that trans fatty acid ( TFA ) consumption may be associated with insulin resistance and diabetes , r and omized placebo-controlled trials ( RCTs ) have yielded conflicting results .
OBJECTIVE In a meta- analysis , we combined all available RCTs that examined the role of  TFA intake  on  glucose homeostasis .