The association between poor performance on SPPB and all-cause mortality remained highly consistent independent of follow-up length , subsets of participants , geographic area , and age of the population .
Conclusions An SPPB score lower than 10 is predictive of all-cause mortality .
The systematic implementation of the SPPB in clinical practice setting s may provide useful prognostic information about the risk of all-cause mortality .
Background The Short Physical Performance Battery ( SPPB ) is a well-established tool to assess lower extremity physical performance status .
Its predictive ability for all-cause mortality has been sparsely reported , but with conflicting results in different subsets of participants .
The aim of this study was to perform a meta- analysis investigating the relationship between SPPB score and all-cause mortality  .
Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation.
RATIONALE Frailty is associated with morbidity and mortality in abdominal organ transplantation but has not been examined in lung transplantation . OBJECTIVES To examine the construct and predictive validity of frailty phenotypes in lung transplant c and i date s. METHODS In a multicenter prospect i ve cohort , we measured frailty with the Fried Frailty Phenotype ( FFP ) and Short Physical Performance Battery ( SPPB ) . We evaluated construct validity through comparisons with conceptually related factors . In a nested case-control study of frail and nonfrail subjects , we measured serum IL-6 , tumor necrosis factor receptor 1 , insulin-like growth factor I , and leptin . We estimated the association between frailty and disability using the Lung Transplant Valued Life Activities disability scale . We estimated the association between frailty and risk of delisting or death before transplant using multivariate logistic and Cox models , respectively . MEASUREMENTS AND MAIN RESULTS Of 395 subjects , 354 completed FFP assessment s and 262 completed SPPB assessment s ; 28 % were frail by FFP ( 95 % confidence interval [ CI ] , 24 - 33 % ) and 10 % based on the SPPB ( 95 % CI , 7 - 14 % ) . By either measure , frailty correlated more strongly with exercise capacity and grip strength than with lung function . Frail subjects tended to have higher plasma IL-6 and tumor necrosis factor receptor 1 and lower insulin-like growth factor I and leptin . Frailty by either measure was associated with greater disability . After adjusting for age , sex , diagnosis , and transplant center , both FFP and SPPB were associated with increased risk of delisting or death before lung transplant . For every 1-point worsening in score , hazard ratios were 1.30 ( 95 % CI , 1.01 - 1.67 ) for FFP and 1.53 ( 95 % CI , 1.19 - 1.59 ) for SPPB . CONCLUSIONS Frailty is prevalent among lung transplant c and i date s and is independently associated with greater disability and an increased risk of delisting or death
The association between poor performance on SPPB and all-cause mortality remained highly consistent independent of follow-up length , subsets of participants , geographic area , and age of the population .
Conclusions An SPPB score lower than 10 is predictive of all-cause mortality .
The systematic implementation of the SPPB in clinical practice setting s may provide useful prognostic information about the risk of all-cause mortality .
Background The Short Physical Performance Battery ( SPPB ) is a well-established tool to assess lower extremity physical performance status .
Its predictive ability for all-cause mortality has been sparsely reported , but with conflicting results in different subsets of participants .
The aim of this study was to perform a meta- analysis investigating the relationship between SPPB score and all-cause mortality  .