The discrepancy between observational and intervention studies suggests that low 25(OH)D is a marker of ill health .
Inflammatory processes involved in disease occurrence and clinical course would reduce 25(OH)D , which would explain why low vitamin D status is reported in a wide range of disorders .
In elderly people , restoration of vitamin D deficits due to ageing and lifestyle changes induced by ill health could explain why low-dose supplementation leads to slight gains in survival
Low serum concentrations of 25-hydroxyvitamin D ( 25[OH]D ) have been associated with many non-skeletal disorders .
However , whether low 25(OH)D is the cause or result of ill health is not known .
Long-term use of nonsteroidal anti-inflammatory drugs decreases the risk of cutaneous melanoma: results of a United States case-control study.
Experimental and observational studies continue to demonstrate conflicting results regarding the role of several commonly used drugs as melanoma chemopreventive agents . This case-control study was design ed to assess the associations between  cutaneous melanoma ( CM ) and exposure to nonsteroidal anti-inflammatory drugs ( NSAIDs ) and  statins in current users . A total of 400 CM and 600 eligible age- and gender-matched community-based controls were prospect ively recruited and interviewed . We assessed participants ' demographic characteristics , CM risk factors , and current and previous use of medications . Multivariable conditional logistic regression models were used to estimate adjusted odds ratios ( ORs ) and 95 % confidence intervals ( CIs ) for associations between  NSAIDs and /or aspirin ( ASA ) , statin exposure , and CM risk .  Half of the subjects were men ( mean age 60 years ) . After adjusting for confounders , use of any type of NSAIDs for more than 5 years significantly reduced the risk of melanoma development compared with the low-exposure group ( adjusted OR=0.57 ; 95 % CI=0.43 - 0.77 ) . Subgroup analyses showed that the observed risk reduction was primarily driven by continuous ASA use ( > 5 years adjusted OR=0.51 , 95 % CI=0.35 - 0.75 ) . No significant protective effect was observed with statin exposure ( OR=0.97 , 95 % CI=0.73 - 1.29 ) . Long-term use of NSAIDs , especially ASA , is associated with a significantly decreased risk of CM development . Clinical intervention studies are warranted to further investigate the potential role of ASA and other NSAIDs as chemopreventive agents for CM
The discrepancy between observational and intervention studies suggests that low 25(OH)D is a marker of ill health .
Inflammatory processes involved in disease occurrence and clinical course would reduce 25(OH)D , which would explain why low vitamin D status is reported in a wide range of disorders .
In elderly people , restoration of vitamin D deficits due to ageing and lifestyle changes induced by ill health could explain why low-dose supplementation leads to slight gains in survival
Low serum concentrations of 25-hydroxyvitamin D ( 25[OH]D ) have been associated with many non-skeletal disorders .
However , whether low 25(OH)D is the cause or result of ill health is not known .