Children with LRTI were found to have significantly lower mean vitamin D levels as compared to controls There was likewise a correlation between vitamin D levels and incidence and severity of LRTI .
Studies related to vitamin D deficiency and lower respiratory tract infections ( LRTI ) in children have inconsistent findings .
The objective of this systematic review was to assess the prevalence of vitamin D deficiency in children with LRTI , and to evaluate the correlation between vitamin D levels and the incidence and severity of LRTI .
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
BACKGROUND Respiratory syncytial virus ( RSV ) is a common cause of severe lower respiratory tract infection in infants . Only a proportion of children infected with RSV require hospitalization . Because known risk factors for severe disease , such as premature birth , can not fully explain differences in disease severity , genetic factors have been implicated . METHODS To study the complexity of RSV susceptibility and to identify the genes and biological pathways involved in its development , we performed a genetic association study involving 470 children hospitalized for RSV bronchiolitis , their parents , and 1008 r and om , population controls . We analyzed 384 single-nucleotide polymorphisms ( SNPs ) in 220 c and i date genes involved in airway mucosal responses , innate immunity , chemotaxis , adaptive immunity , and allergic asthma . RESULTS SNPs in the innate immune genes VDR ( rs10735810 ; P=.0017 ) , JUN ( rs11688 ; P=.0093 ) , IFNA5 ( rs10757212 ; P=.0093 ) , and NOS2 ( rs1060826 ; P=.0031 ) demonstrated the strongest association with bronchiolitis . Apart from association at the allele level , these 4 SNPs also demonstrated association at the genotype level ( P=.0056 , P=.0285 , P=.0372 , and P=.0117 for the SNPs in VDR , JUN , IFNA5 , and NOS2 , respectively ) . The role of innate immunity as a process was reinforced by association of the whole group of innate immune SNPs when the global test for groups of genes was applied ( P=.046 ) . CONCLUSION SNPs in innate immune genes are important in determining susceptibility to RSV bronchiolitis
Children with LRTI were found to have significantly lower mean vitamin D levels as compared to controls There was likewise a correlation between vitamin D levels and incidence and severity of LRTI .
Studies related to vitamin D deficiency and lower respiratory tract infections ( LRTI ) in children have inconsistent findings .
The objective of this systematic review was to assess the prevalence of vitamin D deficiency in children with LRTI , and to evaluate the correlation between vitamin D levels and the incidence and severity of LRTI .