A metaregression analysis indicated that , after adjusting for possible confounders , studies where fluoxetine was the experimental agent were positively associated with treatment effect , indicating a significant advantage for fluoxetine .
The evidence that the outcome of fluoxetine trials varied according to whether this drug was used as a new compound or a reference one suggests the presence of bias
The present study investigated whether the outcome of r and omized clinical trials study ing fluoxetine favored fluoxetine , where this was the experimental agent , and favored comparator antidepressants in trials where fluoxetine was the reference agent .
Moclobemide versus fluoxetine for a major depressive episode
The efficacy and tolerability of moclobemide ( 300–600 mg daily ) and fluoxetine ( 20–40 mg daily ) were compared in a 6-week , double-blind study of 65 in patients and 34 out patients suffering from major depressive episodes ( DSM III-R ) . No statistically significant differences between the two treatment groups were noted regarding efficacy ( HDRS , CGI ) or safety ( adverse events , laboratory examination , vital signs ) . Moclobemide ( 300–600 mg daily ) and fluoxetine ( 20–40 mg daily ) would thus appear to be comparable both in antidepressant efficacy and tolerability . Doubling the low dosage in non-responders after 3 weeks result ed in a statistically significant improvement of CGI in the moclobemide group by comparison with the fluoxetine group at study end , suggesting that 600 mg moclobemide/day can still improve the patient 's condition , while 40 mg fluoxetine/day does not . Sexual dysfunction was reported in two patients taking fluoxetine
A metaregression analysis indicated that , after adjusting for possible confounders , studies where fluoxetine was the experimental agent were positively associated with treatment effect , indicating a significant advantage for fluoxetine .
The evidence that the outcome of fluoxetine trials varied according to whether this drug was used as a new compound or a reference one suggests the presence of bias
The present study investigated whether the outcome of r and omized clinical trials study ing fluoxetine favored fluoxetine , where this was the experimental agent , and favored comparator antidepressants in trials where fluoxetine was the reference agent .