In conclusion , this review supports the hypothesis that hypovitaminosis D is associated with adverse outcomes after diverse surgical procedures .
The importance of vitamin D for musculoskeletal health has long been recognized , and awareness of significant extra-skeletal effects in health and disease is rapidly emerging .
Although it has been possible for many decades to quantify serum markers of vitamin D deficiency , and to correct deficiency at low cost and with high safety , the influence of vitamin D status on post-surgical outcomes has only recently been identified as a research topic of interest .
To the present , these data have not been the subject matter of formal review .
Accordingly , we conducted a systematic review to assess the association between perioperative vitamin D status and outcomes after surgery .
Treatment of vitamin D depletion after Roux-en-Y gastric bypass: a randomized prospective clinical trial.
BACKGROUND A high prevalence ( 60 % ) of vitamin D ( VitD ) depletion , defined as a serum 25-hydroxyvitamin D level of < or = 20 ng/mL , is present in preoperative morbidly obese patients . Despite daily supplementation with 800 IU VitD and 1500 mg calcium after Roux-en-Y gastric bypass ( RYGB ) , VitD depletion persists in almost one half ( 44 % ) of patients . However , the optimal management of VitD depletion after RYGB and the potential benefits of such treatment are currently unknown . METHODS A total of 60 VitD-depleted morbidly obese women were r and omly assigned to receive 50,000 IU of VitD weekly after RYGB ( group 1 ; n = 30 ) or no additional VitD after RYGB ( group 2 ; n = 30 ) . All patients received a daily supplement of 800 IU VitD and 1500 mg calcium . The serum calcium , parathyroid hormone , 25-hydroxyvitamin D , bone-specific alkaline phosphatase , urinary N-telopeptide , and bone mineral density were measured preoperatively and 1 year after RYGB . Question naires were used to assess other potential sources of VitD , including sunlight exposure and ingestion of VitD-containing foods/liquids . RESULTS At 1 year after RYGB , VitD depletion and mean 25-hydroxyvitamin D level had improved significantly in group 1 ( 14 % and 37.8 ng/mL , respectively ) compared with the values in group 2 ( 85 % and 15.2 ng/mL , respectively ; P < .001 for both ) . A significant 33 % retardation in hip bone mineral density decline ( P = .043 ) and a significantly greater resolution of hypertension was seen in group 1 ( 75 % versus 32 % ; P = .029 ) . No significant adverse effects were encountered from pharmacologic VitD therapy . CONCLUSION The results of our study have shown that 50,000 IU of VitD weekly after RYGB safely corrects VitD depletion in most women , attenuates cortical bone loss , and improves resolution of hypertension
In conclusion , this review supports the hypothesis that hypovitaminosis D is associated with adverse outcomes after diverse surgical procedures .
The importance of vitamin D for musculoskeletal health has long been recognized , and awareness of significant extra-skeletal effects in health and disease is rapidly emerging .
Although it has been possible for many decades to quantify serum markers of vitamin D deficiency , and to correct deficiency at low cost and with high safety , the influence of vitamin D status on post-surgical outcomes has only recently been identified as a research topic of interest .
To the present , these data have not been the subject matter of formal review .
Accordingly , we conducted a systematic review to assess the association between perioperative vitamin D status and outcomes after surgery .