We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
Primary prevention of asthma and atopy during childhood by allergen avoidance in infancy: a randomised controlled study
Background : Recent increases in the prevalence of asthma and atopy emphasise the need for devising effective methods for primary prevention in children at high risk of atopy . Method : A birth cohort of genetically at risk infants was recruited in 1990 to a r and omised controlled study . Allergen avoidance measures were instituted from birth in the prophylactic group ( n=58 ) . Infants were either breast fed with mother on a low allergen diet or given an extensively hydrolysed formula . Exposure to house dust mite was reduced by the use of an acaricide and mattress covers . The control group ( n=62 ) followed st and ard advice as normally given by the health visitors . At age 8 , all 120 children completed a question naire and 110 ( 92 % ) had all assessment s ( skin prick test , spirometry , and bronchial challenges ) . Results : In the prophylactic group eight children ( 13.8 % ) had current wheeze compared with 17 ( 27.4 % ) in the control group ( p=0.08 ) . Respective figures were eight ( 13.8 % ) and 20 ( 32.3 % ) for nocturnal cough ( p=0.02 ) and 11 of 55 ( 20.0 % ) and 29 of 62 ( 46.8 % ) for atopy ( p=0.003 ) . After adjusting for confounding variables , the prophylactic group was found to be at a significantly reduced risk for current wheeze ( odds ratio ( OR ) 0.26 ( 95 % confidence interval ( CI ) 0.07 to 0.96 ) ) , nocturnal cough ( OR 0.22 ( 95 % CI 0.06 to 0.83 ) ) , asthma as defined by wheeze and bronchial hyperresponsiveness ( OR 0.11 ( 95 % CI 0.01 to 1.02 ) ) , and atopy ( OR 0.21 ( 95 % CI 0.07 to 0.62 ) ) . Conclusion : Strict allergen avoidance in infancy in high risk children reduces the development of allergic sensitisation to house dust mite . Our results suggest that this may prevent some cases of childhood asthma
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .