In conclusion , statins were effective in preventing postoperative adhesion , as assessed based on gross and microscopic adhesion scores in rats
Adhesion is a significant concern after surgery .
Many research ers studied the anti-adhesive effect of statin , of which results were inconsistent .
Thus , we purpose d to perform a systematic review and meta- analysis to evaluate the effect of statins on postoperative adhesion in an experimental study .
Evaluation of topical application and systemic administration of rosuvastatin in preventing epidural fibrosis in rats.
BACKGROUND CONTEXT Epidural fibrosis is a major challenge in spine surgery , with some patients having recurrent symptoms secondary to excessive formation of scar tissue result ing in neurologic compression . One of the most important factors initiating the epidural fibrosis is assumed to be the transforming growth factor-1β ( TGF-1β ) . Rosuvastatin ( ROS ) has shown to demonstrate preventive effects over fibrosis via inhibiting the TGF-1β . PURPOSE We hypothesized that ROS might have preventive effects over epidural fibrosis through the inhibition of TGF-1β pathways . STUDY DESIGN Experimental animal study . METHODS Forty-eight adult male Wistar Albino rats were equally and r and omly divided into four groups ( laminectomy , spongostan , topical ROS , and systemic ROS ) . Laminectomy was performed at the L3 level in all rats . Four weeks later , the extent of epidural fibrosis was assessed both macroscopically and histopathologically . RESULTS Our data revealed that topical application and systemic administration of ROS both were effective in reducing epidural fibrosis formation . Furthermore , the systemic administration of ROS yielded better results than topical application . CONCLUSIONS Both topical application and systemic administration of ROS show meaningful preventive effects over epidural fibrosis through multiple mechanisms . The results of our study provide the first experimental evidence of the preventive effects of ROS over epidural fibrosis
In conclusion , statins were effective in preventing postoperative adhesion , as assessed based on gross and microscopic adhesion scores in rats
Adhesion is a significant concern after surgery .
Many research ers studied the anti-adhesive effect of statin , of which results were inconsistent .
Thus , we purpose d to perform a systematic review and meta- analysis to evaluate the effect of statins on postoperative adhesion in an experimental study .