The systematic review revealed widespread utilization of developmentally appropriate QL instruments but less frequent use of both self and proxy reports and an inconsistent approach to age group specificities .
Research on the quality of life ( QL ) of children/adolescents with psychological disorders has flourished over the last few decades .
Given the developmental challenges of QL measurements in pediatric population s , the aim of this study was to ascertain the extent to which a developmental approach to  QL assessment has been applied to pedopsychiatric QL research .
Transitioning to OROS® methylphenidate from atomoxetine is effective in children and adolescents with ADHD
Objective : To explore the clinical outcomes of children/adolescents with attention-deficit/hyperactivity disorder ( ADHD ) who required a therapy switch from atomoxetine to OROS ® methylpheni date ( MPH ) .  Methods : This prospect i ve , noninterventional study involved patients aged 6–18 years with a confirmed diagnosis of ADHD who experienced insufficient clinical response and /or poor tolerability during atomoxetine treatment . Patients were transitioned to OROS MPH and followed for 12 weeks . ADHD symptoms , functional outcomes , health-related quality of life ( HRQoL ) and tolerability were assessed throughout the study . Results : 42 patients ( intention-to-treat ) transitioned from atomoxetine 43.2 plus 14.7 mg onto OROS MPH 33.0 plus 17.7 mg ( mean daily starting dose ) , increasing to 38.6 plus 17.6 mg at the final visit . Median treatment duration was 85 days ( range : 3–155 ) . Compared with baseline , symptoms , functional outcome and HRQoL improved after transitioning to OROS MPH as assessed by the Conners ’ Parent Rating Scale ( mean change from baseline : -10.1 ± 11.6 ; p < 0.0001 ) , Children ’s Global Assessment Scale ( 8.7 ± 16.2 ; p = 0.0015 ) and ILC-LQ0–28 scores ( parents ’ rating from 14.9 ± 3.6 [ baseline ] to 17.5 ± 4.8 [ study end ] ; p = 0.0002 ; patients ’ rating from 16.9 ± 3.9 [ baseline ] to 19.3 ± 4.4 [ study end ] ; p = 0.0003 ) . Social interactions and late afternoon tasks ( playing with other children , household chores , school homework and behavior towards visitors/at visits ) improved ( p < 0.001 ) . Approximately 62 % expressed satisfaction ( ‘ very good ’ or ` good ’ ) with OROS MPH therapy compared with prior atomoxetine with respect to symptom control in the late afternoon . The most common treatment-emergent adverse events after switching were involuntary muscle contractions ( tics ; 16.7 % ) , insomnia ( 14.3 % ) , abdominal pain ( 9.5 % ) and headache ( 9.5 % ) . No clinical ly relevant changes in body weight or vital signs were observed . Conclusion : In this naturalistic setting , transitioning from atomoxetine to OROS MPH was associated with improved ADHD symptoms and impacted positively on patients ’ and parents ’ HRQoL and disease burden in ADHD children who demonstrated an insufficient response and /or poor tolerability to atomoxetine
The systematic review revealed widespread utilization of developmentally appropriate QL instruments but less frequent use of both self and proxy reports and an inconsistent approach to age group specificities .
Research on the quality of life ( QL ) of children/adolescents with psychological disorders has flourished over the last few decades .
Given the developmental challenges of QL measurements in pediatric population s , the aim of this study was to ascertain the extent to which a developmental approach to  QL assessment has been applied to pedopsychiatric QL research .