The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .
Cytokine modifications after tension-free hernioplasty or open conventional inguinal hernia repair.
BACKGROUND The purpose of this study was to evaluate the involvement of proinflammatory cytokines ( interferon-gamma [ INF-gamma ] , interleukin [IL]-6 ) and anti-inflammatory cytokines ( IL-4 , IL-l0 , IL-13 ) in patients undergoing Lichtenstein tension-free hernioplasty ( LH ) using polypropylene prosthetic material s  or conventional Bassini hernia ( BH ) repair . METHODS Thirty-five male patients ( age range 25 to 60 years ) with unilateral inguinal hernia without complications or recurrence were included in this study . R and omly , patients underwent conventional operation and had their inguinal hernia repair performed with polypropylene mesh . Peripheral venous blood sample s were collected 24 hours prior to surgery and then 6 , 24 , 48 , and 168 hours postoperatively . Fifteen healthy controls were included . RESULTS We present evidence that LH patients showed both an increased serum level of Thelper 1 (Th1)-like cytokines ( IFN-gamma ) and an increase in Thelper 2 (Th2)-like cytokines ( IL-6 and IL-l0 ) , associated with a slight reduction of peripheral blood mononuclear cells ( P BMC ) producing IL-6 and a normal level of P BMC producing IFN-gamma , IL-l0 , IL-13 , and IL-4 . Whereas BH patients showed in part an amplification of Th2-like cells , characterized by the sustained serum production of IL-6 and IL-l0 , associated with an increase in IL-l0 secreted by in vitro stimulated PMBC . CONCLUSIONS Our data show that LH is associated with a higher production of inflammatory cytokines ( IFN-gamma and IL-6 ) compared with BH , likely induced by the presence of the polypropylene prostheses
The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .