In both rodent and cell culture models , CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus .
In rodent models , CBD was found to attenuate alcohol-induced hepatotoxicity , specifically , alcohol-induced steatosis .
Finally , findings from pre clinical rodent models also indicate that CBD attenuates cue-elicited and stress-elicited alcohol seeking , alcohol self-administration , withdrawal-induced convulsions , and impulsive discounting of delayed rewards .
In human studies , CBD was well tolerated and did not interact with the subjective effects of alcohol .
Collectively , given its favorable effects on alcohol-related harms and addiction phenotypes in pre clinical models , CBD appears to have promise as a c and i date AUD pharmacotherapy .
This is further bolstered by the absence of abuse liability and its general tolerability .
There is substantial interest in the therapeutic potential of cannabidiol ( CBD ) , a nonpsychoactive cannabinoid found in plants of the genus Cannabis .
The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a c and i date pharmacotherapy for alcohol use disorder ( AUD ) .
Effects of Zonisamide in the Treatment of Alcohol Dependence
Objective : Anticonvulsant drugs have been used in the treatment of alcohol dependence . The purpose of the present study was to evaluate tolerance and safety of zonisamide in a sample of patients presenting alcohol dependence . Methods : Open-label zonisamide  was examined in 22 out patients with Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition alcohol dependence .  Zonisamide was started at a dose of 50 mg/d and titrated to a maximun dose of 300 mg/d . Subjects received a baseline evaluation including Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition and the Severity of Alcohol Dependence Scale . Alcohol craving and alcohol consumption were assessed at weeks 2 , 4 , 6 , 8 , 10 , and 12 . The concentration of & ggr;-glutamyltransferase was used as an indirect measure of alcohol consumption . Results : Significant improvement was observed in visual analog scale for craving severity scores , weekly drink consumption , and & ggr;-glutamyltransferase .  Zonisamide was well tolerated , with only a dropout due to adverse events . Conclusions : Zonisamide is safe and well tolerated in this sample and associated with improvement in alcohol craving and alcohol consumption . A placebo-controlled study would be of interest
In both rodent and cell culture models , CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus .
In rodent models , CBD was found to attenuate alcohol-induced hepatotoxicity , specifically , alcohol-induced steatosis .
Finally , findings from pre clinical rodent models also indicate that CBD attenuates cue-elicited and stress-elicited alcohol seeking , alcohol self-administration , withdrawal-induced convulsions , and impulsive discounting of delayed rewards .
In human studies , CBD was well tolerated and did not interact with the subjective effects of alcohol .
Collectively , given its favorable effects on alcohol-related harms and addiction phenotypes in pre clinical models , CBD appears to have promise as a c and i date AUD pharmacotherapy .
This is further bolstered by the absence of abuse liability and its general tolerability .
There is substantial interest in the therapeutic potential of cannabidiol ( CBD ) , a nonpsychoactive cannabinoid found in plants of the genus Cannabis .
The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a c and i date pharmacotherapy for alcohol use disorder ( AUD ) .