The available evidence suggests the early changes in cognition may predict treatment response in individuals with MDD .
The results depict an emerging trend towards early changes in facial emotion recognition ( i.e. , a hot cognitive process ) as a predictor of treatment outcome .
Conclusion : The identification of reliable early treatment predictors of antidepressant response would be clinical ly significant , enabling clinicians to more accurately evaluate the efficacy of selected treatment avenues .
HIGHLIGHTSCognitive dysfunction is a principal feature and determinant of health outcome in MDD.Cognitive changes have shown to occur prior to improvements in mood symptoms .
Early changes in emotional processing may predict treatment response in MDD
Background : Despite the widespread use of antidepressants in clinical practice , the current trial‐ and ‐error approach to medication selection contributes to treatment failure and underscores the need to identify reliable predictors of antidepressant response .
Since changes in measures of cognition have been reported to occur early in treatment and prior to improvements in overall mood symptoms , the present review aims to determine whether early changes in measures of cognition can predict response in individuals with MDD .
A randomized trial of the anti-depressant effects of low- and high-frequency transcranial magnetic stimulation in treatment-resistant depression.
BACKGROUND The majority of studies investigating the effectiveness of repetitive transcranial magnetic stimulation ( rTMS ) as a treatment for major depression have focused on high-frequency rTMS to the left prefrontal cortex ( HFL-rTMS ) . In addition , low-frequency right prefrontal rTMS ( LFR-rTMS ) has also been shown to have antidepressant properties . To date only a small number of studies have directly compared the efficacy of these two approaches . METHODS The aim of this study , therefore , was to investigate further whether LFR-rTMS is as effective as HFL-rTMS in the treatment of major depression . Twenty-seven patients were r and omized to one of two treatment arms ( HFL-rTMS or LFR-rTMS ) for 3 weeks with a possible 1-week extension . Non-responders were offered the opportunity of crossing over to the other treatment type . Stimulation parameters for HFL-rTMS were 30 stimulation trains of 5 s duration at 100 % of the resting motor threshold ( RMT ) ; for LFR-rTMS , stimulation was applied in four trains of 180 s duration ( 30 s inter-train interval ) at 110 % of the RMT . Stimulation was provided 5-week days per week . RESULTS There were significant improvements seen from baseline to end point irrespective of group and on all clinical outcome measures . In addition , there was no deterioration in any of the measures used to assess cognitive change , and significant improvements were seen on measures of immediate verbal memory and verbal fluency . CONCLUSIONS HFL-rTMS and LFR-rTMS appear to be equally efficacious in treating major depression . This study adds to the growing literature supporting LFR-rTMS as an additional viable method of rTMS delivery in the treatment of depression
The available evidence suggests the early changes in cognition may predict treatment response in individuals with MDD .
The results depict an emerging trend towards early changes in facial emotion recognition ( i.e. , a hot cognitive process ) as a predictor of treatment outcome .
Conclusion : The identification of reliable early treatment predictors of antidepressant response would be clinical ly significant , enabling clinicians to more accurately evaluate the efficacy of selected treatment avenues .
HIGHLIGHTSCognitive dysfunction is a principal feature and determinant of health outcome in MDD.Cognitive changes have shown to occur prior to improvements in mood symptoms .
Early changes in emotional processing may predict treatment response in MDD
Background : Despite the widespread use of antidepressants in clinical practice , the current trial‐ and ‐error approach to medication selection contributes to treatment failure and underscores the need to identify reliable predictors of antidepressant response .
Since changes in measures of cognition have been reported to occur early in treatment and prior to improvements in overall mood symptoms , the present review aims to determine whether early changes in measures of cognition can predict response in individuals with MDD .