This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
Vitamin D and Evening Primrose Oil Administration Improve Glycemia and Lipid Profiles in Women with Gestational Diabetes
Abstract Limited data are available assessing the effects of vitamin D and evening primrose oil ( EPO ) administration on markers of insulin resistance and lipid concentrations in gestational diabetes mellitus ( GDM ) . This study was design ed to evaluate the effects of vitamin D and EPO administration on insulin resistance and lipid concentrations among women with GDM . In this prospect i ve r and omized , double-blind , placebo-controlled clinical trial , 60 participants with GDM were divided into 2 groups of either 1000 IU vitamin D3 and 1000 mg EPO or placebo for 6 weeks . At the beginning and end of the study , fasting blood sample s were obtained from the participants to measure related variables . After 6 weeks of intervention , changes in fasting plasma glucose ( −3.6 ± 7.5 vs. + 1.5 ± 11.4 mg/dL , P = 0.04 ) , serum insulin concentrations ( −2.0 ± 5.3 vs. + 4.6 ± 10.7 µIU/mL , P = 0.004 ) , homeostasis model of assessment ( HOMA ) insulin resistance ( −0.5 ± 1.1 vs. + 1.1 ± 2.5 , P = 0.003 ) , HOMA-B cell function ( −7.7 ± 23.3 vs. + 17.4 ± 42.9 , P = 0.007 ) and the quantitative insulin sensitivity check index ( + 0.01 ± 0.02 vs. −0.01 ± 0.02 , P = 0.007 ) in the vitamin D plus EPO group were significantly different from the placebo group . In addition , compared with the placebo , vitamin D and EPO supplementation result ed in significant reductions in serum TAG ( −20.0 ± 54.3 vs. + 34.3 ± 38.2 mg/dL , P < 0.001 ) , VLDL ( −4.0 ± 10.9 vs. + 6.9 ± 7.6 mg/dL , P < 0.001 ) , TC ( −22.1 ± 32.6 vs. + 5.3 ± 20.1 mg/dL , P < 0.001 ) , LDL concentrations ( −18.0 ± 25.5 vs. + 1.8 ± 15.7 mg/dL , P = 0.001 ) and TC/HDL ( −0.3 ± 0.4 vs. + 0.3 ± 0.5 mg/dL , P < 0.001 ) . We did not observe any significant effect of vitamin D and EPO supplementation on serum HDL concentrations . Clinical trial registration number : http://www.i rct .ir : I RCT 201509115623N52
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .