Treatment with SSRIs rather than placebo was associated with clinical improvement by the end of the first week of use .
CONCLUSIONS Treatment with SSRIs is associated with symptomatic improvement in depression by the end of the first week of use , and the improvement continues at a decreasing rate for at least 6 weeks
CONTEXT Selective serotonin reuptake inhibitors ( SSRIs ) are often described as having a delayed onset of effect in the treatment of depression .
However , some trials have reported clinical improvement as early as the first week of treatment .
OBJECTIVE To test the alternative hypotheses of delayed vs early onset of antidepressant action with SSRIs in patients with unipolar depression .
Efficacy comparison of escitalopram and citalopram in the treatment of major depressive disorder: pooled analysis of placebo-controlled trials.
BACKGROUND Citalopram is a racemic selective serotonin reuptake inhibitor ( SSRI ) indicated for the treatment of depression . Citalopram is a racemate and its serotonin reuptake inhibitory activity resides primarily in the single S-isomer , escitalopram , which is now being evaluated for its potential usefulness in the treatment of depression and other psychiatric disorders . RESULTS from placebo-controlled studies that also included citalopram as an active control have shown that escitalopram is effective in treating depression and associated symptoms of anxiety . However , none of these studies was powered sufficiently to detect differences between active treatment groups . The goal of the present analysis is to evaluate the efficacy of escitalopram compared with citalopram in the treatment of major depressive disorder . METHOD Data were pooled from three similarly design ed , r and omized , double-blind , placebo-controlled trials of escitalopram ( 10 - 20 mg/day ) and citalopram ( 20 - 40 mg/day ) . Patients were male or female , greater than or equal to 18 years of age , who met criteria for a major depressive episode with a Montgomery Asberg Depression Rating Scale ( MADRS ) score greater than or equal to 22 at baseline . Efficacy measures included change from baseline in MADRS score and the Clinical Global Impression of Improvement ( CGI-I ) scale . Improvement in associated symptoms of anxiety was measured using the change from baseline in the MADRS inner tension item . RESULTS Both escitalopram and citalopram significantly improved depression and anxiety symptoms compared with placebo , and there were significantly more MADRS responders ( defined as > /=50 % improvement in MADRS scores at end point ) in the escitalopram and citalopram treatment groups . Escitalopram treatment was associated with statistically significant improvements in all efficacy measures relative to placebo after 1 week of treatment , whereas citalopram treatment statistically separated from placebo at the end of week 4 ( CGI-I and MADRS inner tension ) or week 6 ( MADRS ) . Escitalopram treatment also was statistically significantly superior to citalopram treatment at a number of time points . CONCLUSION These data support the effectiveness of escitalopram and citalopram in the treatment of major depressive disorder , and suggest escitalopram may have a faster onset and greater overall magnitude of effect than citalopram in improving symptoms of depression and anxiety in patients with major depressive disorder
Treatment with SSRIs rather than placebo was associated with clinical improvement by the end of the first week of use .
CONCLUSIONS Treatment with SSRIs is associated with symptomatic improvement in depression by the end of the first week of use , and the improvement continues at a decreasing rate for at least 6 weeks
CONTEXT Selective serotonin reuptake inhibitors ( SSRIs ) are often described as having a delayed onset of effect in the treatment of depression .
However , some trials have reported clinical improvement as early as the first week of treatment .
OBJECTIVE To test the alternative hypotheses of delayed vs early onset of antidepressant action with SSRIs in patients with unipolar depression .