In general , active non-invasive anaesthetic methods seemed to provide favourable results compared to placebo or no anaesthesia , and topical anaesthetic drugs and PSF seemed to result in a better pain reduction than skin cooling .
However , the current evidence is insufficient to provide recommendations for daily clinical practice .
Future studies should also evaluate sex differences in pain perception , have uniformity with regard to vali date d pain measurement scales and address clinical ly significant differences in pain reduction besides statistically significant differences
Pain is a common side-effect of dermatological laser procedures .
Non-invasive anaesthetic drugs and anaesthetic procedures can be used to provide pain relief and increase patient satisfaction and treatment efficacy .
However , it remains unclear which method provides the best pain relief .
The objective of this systematic review was therefore to assess the efficacy and safety of non-invasive anaesthetic methods during dermatological laser procedures .
Effect of piroxicam gel for pain control and inflammation in Nd:YAG 1064-nm laser hair removal.
BACKGROUND Laser-assisted hair removal is a variably uncomfortable and painful procedure . OBJECTIVE The aim of this study was to investigate the efficacy of piroxicam gel on pain control and subsequent inflammation in Nd : YAG 1064 nm laser hair removal in women volunteers . METHODS Fifty women volunteers were enrolled in this prospect i ve , r and omised , placebo-controlled study over a 6-month period . Subjects were r and omly assigned to receive piroxicam gel as Group P or saline as a control group . Topical analgesic and saline were applied to the treatment sites for 45 minutes . The pain scores ( VAS ) and side effects were recorded before the hair removal , during the hair removal , at the end of the hair removal , and after 1 hour , 2 hours and 24 hours after the hair removal . RESULTS Subject characteristics and treatment setting s in Nd : YAG 1064 nm laser were similar in both groups . The pain scores ( VAS ) were significantly lower in the Group P than those of the control group during the hair removal ( p < 0.001 ) . Inflammatory side effects such as erythema , edema , and folliculitis , were more frequent in the control group than those of Group P during the procedure ( p < 0.001 ) . CONCLUSION This study showed that piroxicam gel provided adequate pain relief after Nd : YAG 1064 nm laser hair removal in women volunteers .  Piroxicam gel was associated with lesser inflammatory side effects when compared to placebo because of its anti-inflammatory effect after the procedure
In general , active non-invasive anaesthetic methods seemed to provide favourable results compared to placebo or no anaesthesia , and topical anaesthetic drugs and PSF seemed to result in a better pain reduction than skin cooling .
However , the current evidence is insufficient to provide recommendations for daily clinical practice .
Future studies should also evaluate sex differences in pain perception , have uniformity with regard to vali date d pain measurement scales and address clinical ly significant differences in pain reduction besides statistically significant differences
Pain is a common side-effect of dermatological laser procedures .
Non-invasive anaesthetic drugs and anaesthetic procedures can be used to provide pain relief and increase patient satisfaction and treatment efficacy .
However , it remains unclear which method provides the best pain relief .
The objective of this systematic review was therefore to assess the efficacy and safety of non-invasive anaesthetic methods during dermatological laser procedures .