Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
A dose–response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial
Abstract Purpose To determine the dose – response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [ 25(OH)D ] among Chinese adults . Methods In this 5-arm , r and omized , double-blinded controlled trial , 76 healthy participants were assigned to orally administrate 0 , 400 , 800 , 1200 or 2000 IU/d of vitamin D3 for 16 weeks . Serum 25(OH)D , parathyroid hormone , calcium , biomarkers of liver and renal function were measured at multiple time points . Results The mean ( SD ) serum 25(OH)D at baseline was 31.6 ( 8.7 ) nmol/L , and the dose – response relationship was curvilinear with a plateau around 6 weeks for all doses . At week 16 , 25(OH)D was increased by 6.0 ( 6.5 ) , 21.7 ( 15.8 ) , 26.3 ( 12.6 ) , 32.0 ( 12.8 ) and 36.3 ( 26.0 ) nmol/L for 0 , 400 , 800 , 1200 and 2000 IU/d ( all P ≤ 0.002 ) , corresponding to approximately 19 , 53 , 67 , 77 and 80 % of reversion of vitamin D deficiency , respectively . Daily intake of 800 IU vitamin D3 reached a targeted 25(OH)D ≥ 30 nmol/L in at least 97.5 % of Chinese , but not a targeted 25(OH)D ≥ 50 nmol/L even with 2000 IU/d . Change of 25(OH)D was inversely associated with change of PTH concentration ( r = −0.39 , P < 0.001 ) after controlling for age and sex . No between-group differences were observed in terms of the change in serum calcium , alanine transaminase , aspartate aminotransferase , gamma-glutamyltransferase and creatinine ( P ≥ 0.22 ) . Conclusions Supplementation with 400 , 800 , 1200 or 2000 IU/d vitamin D could improve the vitamin D deficiency with various degrees . Whether 2000 IU/d vitamin D3 would generate a better result without side effect requires more studies with larger sample s in future
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .