Conclusions Whole flaxseed , but not flaxseed oil and lignan extract , has significant effects on improving glycemic control .
Context The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent .
Objective The present study aim ed to systematic ally review and analyze r and omized controlled trials assessing the effects of flaxseed consumption on glycemic control .
Flaxseed and Cardiovascular Risk Factors: Results from a Double Blind, Randomized, Controlled Clinical Trial
Objective : Flaxseed is a rich source of alpha linolenic acid ( ALA ) , fiber and lignans , making it a potentially attractive functional food for modulating cardiovascular risk . We studied the effects of flaxseed on markers of cardiovascular risk in hypercholesterolemic adults . Methods : Sixty-two men and post-menopausal women with pre- study low density lipoprotein cholesterol ( LDL-C ) between 130 and 200 mg/dl were r and omized to 40g/day of ground flaxseed-containing baked products or matching wheat bran products for 10 weeks while following a low fat , low cholesterol diet .  Fasting lipoproteins , measures of insulin resistance , inflammation , oxidative stress , and safety were assessed at 0 , 5 and 10 weeks . Results : Flaxseed was well-tolerated , and increased serum levels of ALA ( p < 0.001 ) . Compared to wheat , flaxseed significantly reduced LDL-C at 5 weeks ( −13 % , p < 0.005 ) , but not at 10 weeks ( −7 % , p = 0.07 ) . Flaxseed  reduced lipoprotein a ( Lp[a ] ) by a net of 14 % ( p = 0.02 ) , and reduced the homeostatic model assessment of insulin resistance ( HOMA-IR ) index by 23.7 % ( p = 0.03 ) compared to wheat at 10 weeks , but did not affect markers of inflammation ( IL-6 , Hs-CRP ) or oxidative stress ( ox LDL , urinary isoprostanes ) at any time points . In men , flaxseed  reduced HDL-C concentrations by a net of 16 % ( p = 0.03 ) and 9 % ( p = 0.05 ) at 5 and 10 weeks , respectively . Conclusions : Ground flaxseed has a modest but short lived LDL-C lowering effect , yet reduces Lp(a ) and improves insulin sensitivity in hyperlipidemic adults . The HDL-C lowering effect of flaxseed in men warrants additional study
Conclusions Whole flaxseed , but not flaxseed oil and lignan extract , has significant effects on improving glycemic control .
Context The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent .
Objective The present study aim ed to systematic ally review and analyze r and omized controlled trials assessing the effects of flaxseed consumption on glycemic control .