Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy
Context : Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D ( 25(OH)D ) response . Objective : We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol . Design : Within-r and omization-group analysis of participants in the Maternal Vitamin D Osteoporosis Study trial of vitamin D  supplementation in pregnancy . Setting : Hospital antenatal clinics . Participants : A total of 829 pregnant women ( 422 placebo , 407 cholecalciferol ) . At 14 and 34 weeks of gestation , maternal anthropometry , health , and lifestyle were assessed and 25(OH)D measured . Compliance was determined using pill counts at 19 and 34 weeks . Interventions : 1000 IU/d of cholecalciferol or matched placebo from 14 weeks of gestation until delivery . Main Outcome Measure : 25(OH)D at 34 weeks , measured in a single batch ( Diasorin Liaison ) . Results : 25(OH)D at 34 weeks of gestation was higher in the women r and omized to vitamin D ( mean [ SD ] , 67.7 [ 21.3 ] nmol/L ) compared with placebo ( 43.1 [ 22.5 ] nmol/L ; P < .001 ) . In women r and omized to cholecalciferol , higher pregnancy weight gain from 14 to 34 weeks of gestation ( kg ) ( β = −0.81 [ 95 % confidence interval −1.39 , −0.22 ] ) , lower compliance with study medication ( % ) ( β = −0.28 [ −0.072 , −0.48 ] ) , lower early pregnancy 25(OH)D ( nmol/L ) ( β = 0.28 [ 0.16 , 0.40 ] ) , and delivery in the winter vs the summer ( β = −10.5 [ −6.4 , −14.6 ] ) were independently associated with lower 25(OH)D at 34 weeks of gestation . Conclusions : Women who gained more weight during pregnancy had lower 25(OH)D in early pregnancy and delivered in winter achieved a lower 25(OH)D in late pregnancy when supplemented with 1000 IU/d cholecalciferol . Future studies should aim to determine appropriate doses to enable consistent repletion of 25(OH)D during pregnancy
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .