Conclusion In patients with paroxysmal atrial fibrillation  , cryoballoon and radiofrequency ablation produce similar results in terms of freedom from recurrent atrial fibrillation or atrial tachyarrhythmias but with a different safety profile , being cryoballoon ablation less associated with cardiac complications but more likely to cause phrenic nerve palsy
Aims To perform an up date d meta- analysis to assess efficacy , safety and technical performance of pulmonary vein isolation using cryoballoon or radiofrequency catheter ablation in patients with paroxysmal or persistent atrial fibrillation .
Cellular damage, platelet activation, and inflammatory response after pulmonary vein isolation: a randomized study comparing radiofrequency ablation with cryoablation.
BACKGROUND Experimental data suggest that use of cryoablation in pulmonary vein isolation ( PVI ) is associated with less cell damage and less thrombus formation compared to radiofrequency ( RF ) energy . OBJECTIVE The purpose of this study was to test the hypothesis that cryoablation significantly reduces markers of cell damage , platelet activation , and inflammation in patients undergoing PVI for treatment of atrial fibrillation ( AF ) . METHODS Sixty patients with symptomatic drug-resistant AF ( age 56 ± 9 years , 48 males , 38 with paroxysmal AF ) were r and omly assigned to undergo PVI using either an open irrigated-tip RF catheter or a cryoballoon . Markers of cell damage ( high-sensitive troponin T [ hs-TnT ] , microparticles ) , platelet activation ( platelet reactivity by aggregometry , expression of platelet surface proteins P-selectin and activated glycoprotein [ GP ] IIb/IIIa ) , and inflammatory response ( high-sensitive C-reactive protein [ hs-CRP ] ) were determined before and up to 48 hours after the procedure . RESULTS PVI result ed in a significant rise in hs-TnT , microparticles , markers of platelet activation , and hs-CRP over time , with distinct temporal patterns for each parameter . However , after Bonferroni correction for repeated measurements , no significant differences were noted in these parameters between patients treated with cryoablation or RF energy . Procedural time was significantly shorter in patients treated with cryoballoon ( 177 ± 30 minutes vs 200 ± 46 minutes , P = .03 ) , with no differences in fluoroscopic time , periprocedural complications , or success rate . CONCLUSION Cryoablation and RF energy result in a comparable rise of markers of cell damage , platelet activation and inflammatory response . The data do not support the concept of an improved safety profile for cryoablation in PVI
Conclusion In patients with paroxysmal atrial fibrillation  , cryoballoon and radiofrequency ablation produce similar results in terms of freedom from recurrent atrial fibrillation or atrial tachyarrhythmias but with a different safety profile , being cryoballoon ablation less associated with cardiac complications but more likely to cause phrenic nerve palsy
Aims To perform an up date d meta- analysis to assess efficacy , safety and technical performance of pulmonary vein isolation using cryoballoon or radiofrequency catheter ablation in patients with paroxysmal or persistent atrial fibrillation .