For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .
Sildenafil citrate (Viagra) is effective and well tolerated for treating erectile dysfunction of psychogenic or mixed aetiology.
Sildenafil citrate ( Viagra ) has been shown to be an effective treatment for erectile dysfunction ( ED ) of organic aetiology . This study assessed the efficacy and tolerability of sildenafil for treating ED of psychogenic and mixed psychogenic/organic aetiology . Men with ED of psychogenic and mixed aetiology were r and omised in a double-blind , fixed-dose study to placebo ( n = 95 ) or sildenafil 10 mg ( n = 90 ) , 25 mg ( n = 85 ) , or 50 mg ( n = 81 ) once daily for 28 days . Efficacy was evaluated with two global efficacy questions , a patient log of erectile activity , a sexual function question naire and a partner question naire . Patients receiving sildenafil  had significantly more grade 3 ( hard enough for penetration ) or grade 4 ( fully hard ) erections per week than patients receiving placebo , and a greater proportion of patients receiving sildenafil reported that treatment had improved their erections ( p < 0.001 ) . Results of the sexual function question naire demonstrated significant improvement for patients with ED receiving sildenafil compared with patients receiving placebo for frequency , hardness and duration of erections ( p < 0.01 ) , and for enjoyment of sexual intercourse and satisfaction with sex life ( p < 0.05 ) . The results of the partner question naire were consistent with the results reported by patients and showed that treatment with sildenafil was associated with significant improvement in the partners ' own sex lives ( p < 0.001 ) . Adverse events were mostly mild to moderate in nature . The commonest adverse events were headache , dyspepsia , flushing , myalgia , arthralgia and flu syndrome . Discontinuations due to treatment-related adverse events were few , ranging from 1.1 % to 6.2 % for patients receiving different doses of sildenafil and 4.2 % for patients receiving placebo . Sildenafil is an effective and well-tolerated treatment for ED of psychogenic or mixed aetiology with once-daily dosing
For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .