Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Comparison of the effect of simvastatin versus simvastatin/ezetimibe versus rosuvastatin on markers of inflammation and oxidative stress in subjects with hypercholesterolemia.
OBJECTIVES Statins may exhibit anti-inflammatory and antioxidant effects . Whether different statins at equivalent doses or the combination of low-dose statin with ezetimibe have comparable anti-inflammatory and antioxidant effects is unknown . The aim of this study was to compare the effects of simvastatin , simvastatin/ezetimibe or rosuvastatin at equivalent low-density lipoprotein cholesterol lowering doses on inflammation and oxidative stress indices in subjects with hypercholesterolemia . METHODS This was a pre-specified analysis of a prospect i ve , r and omized , open-label , blinded endpoint ( PROBE ) study . We enrolled one hundred and fifty three ( n = 153 ) hypercholesterolemic subjects who were r and omized to receive simvastatin 40 mg or simvastatin/ezetimibe 10/10 mg or rosuvastatin 10 mg daily .  Plasma 8-Epi prostagl and in F2 alpha ( 8-epiPGF2a ) , oxidized LDL ( oxLDL ) and lipoprotein-associated phospholipase A2 ( Lp-PLA2 ) activity and mass were measured at baseline and following 12 weeks of treatment . RESULTS A significant reduction in plasma 8-isoprostane and oxLDL levels was observed in all treatment groups [ by 10 % , 8 % and 6 % ( p < 0.05 compared with baseline ) and 41 % , 40 % and 39 % ( p < 0.001 compared with baseline ) in simvastatin , simvastatin/ezetimibe and rosuvastatin groups , respectively ] . In all treatment groups a significant reduction in total plasma Lp-PLA2 activity and mass was observed ( by 36 % , 31 % and 38 % and 36 % , 32 % and 32 % for simvastatin , simvastatin/ezetimibe and rosuvastatin , respectively , p < 0.001 compared with baseline ) . No intergroup differences were observed . CONCLUSIONS Simvastatin 40 mg , simvastatin/ezetimibe 10/10 mg and rosuvastatin 10 mg significantly reduced 8-epiPGF2a , oxLDL and Lp-PLA2 activity and mass to a similar extent
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .