Based on 88 eligible observational studies , level of evidence grading and quantitative meta-analyses indicated that there is limited available evidence that the total volume or patterns of sedentary behaviour are associated with health in children and adolescents when accounting for moderate-intensity to vigorous-intensity physical activity or focusing on studies with low risk of bias .
Quality evidence from studies with robust design s and methods , objective measures of sitting , examining associations for various health outcomes , is needed to better underst and if the overall volume or patterns of sedentary behaviour are independent determinants of health in children and adolescents
Sedentary behaviour has emerged as a unique determinant of health in adults .
Studies in children and adolescents have been less consistent .
We review ed the evidence to determine if the total volume and patterns ( i.e. breaks and bouts ) of objective ly measured sedentary  behaviour  were associated with adverse health outcomes in young people , independent of moderate-intensity to vigorous-intensity physical activity .
Objectively Measured Sedentary Time May Predict Insulin Resistance Independent of Moderate- and Vigorous-Intensity Physical Activity
OBJECTIVE To examine the prospect i ve association between objective ly measured time spent sedentary and insulin resistance and whether this association is independent of moderate- and vigorous-intensity physical activity ( MVPA ) and other relevant confounders . RESEARCH DESIGN AND METHODS This was a population -based study ( Medical Research Council Ely study ) in 376 middle-aged adults ( 166 men ; 210 women ) over 5.6 years of follow-up .  Physical activity and sedentary time were measured objective ly by individually calibrated minute-by-minute heart rate monitoring at both baseline and follow-up .  Sedentary time  was calculated as the heart rate observations ( in minutes ) below an individually predetermined threshold ( flex heart rate ) and expressed as a percentage of total monitored time during waking hours over 4 days . The percentage of time spent above 1.75 × resting heart rate represented MVPA . Fasting plasma insulin was used as a surrogate measure of insulin resistance . RESULTS Time spent sedentary  at baseline was significantly and positively associated with log fasting insulin at follow-up ( β = 0.003 , 95 % CI 0.0006–0.006 , P = 0.015 ) independent of baseline age , sex , fat mass , fasting insulin , smoking status , and follow-up time . After further adjustment for MVPA , this association was somewhat strengthened ( β = 0.004 , 95 % CI 0.0009–0.006 , P = 0.009 ) . CONCLUSIONS Time spent sedentary predicts higher levels of fasting insulin independent of the amount of time spent at moderate- and vigorous-intensity activity levels . This highlights the importance of reducing sedentary time in order to improve metabolic health , possibly in addition to the benefits associated with a physically active lifestyle
Based on 88 eligible observational studies , level of evidence grading and quantitative meta-analyses indicated that there is limited available evidence that the total volume or patterns of sedentary behaviour are associated with health in children and adolescents when accounting for moderate-intensity to vigorous-intensity physical activity or focusing on studies with low risk of bias .
Quality evidence from studies with robust design s and methods , objective measures of sitting , examining associations for various health outcomes , is needed to better underst and if the overall volume or patterns of sedentary behaviour are independent determinants of health in children and adolescents
Sedentary behaviour has emerged as a unique determinant of health in adults .
Studies in children and adolescents have been less consistent .
We review ed the evidence to determine if the total volume and patterns ( i.e. breaks and bouts ) of objective ly measured sedentary  behaviour  were associated with adverse health outcomes in young people , independent of moderate-intensity to vigorous-intensity physical activity .