Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women.
Coffee is a rich source of polyphenols , primarily chlorogenic acids ( CGA ) . Certain polyphenols and polyphenol-rich foods and beverages have been shown to improve endothelial function and lower blood pressure ( BP ) . The aim of the present study was to investigate the acute effect of two doses of CGA ( 5-CGA ) on endothelial function and BP . In a cross-over study , 16 healthy men and women received : ( i ) 0 mg purified 5-CGA ( control group ) ; ( ii ) 450 mg purified 5-CGA ; ( iii ) 900 mg purified 5-CGA ; and ( iv ) 200 mg purified (-)-epicatechin ( positive control ) in r and om order one week apart . Peak and continuous mean ( 60 to 240 s post ischaemia ) flow-mediated dilation ( FMD ) was measured at baseline , 1 h and 4 h. BP was measured at baseline and every 30 min to 4 h. Plasma CGA and epicatechin levels were significantly increased at both 1 h and 4 h post their respective treatments . Peak FMD was not significantly altered by either dose of 5-CGA or the epicatechin , relative to control ( p > 0.05 ) . Relative to control , effects on continuous mean FMD response following 450 mg 5-CGA and 900 mg of 5-CGA ( 0.47 ± 0.16 % , p = 0.016 and 0.65 ± 0.16 % , p < 0.001 , respectively ) at 1 h and ( 0.18 ± 0.17 % , p = 0.99 and 0.44 ± 0.16 % , p < 0.05 , respectively ) at 4 h. There was no significant effect of any of the treatments on BP . In conclusion , the present study has found no significant effect of 5-CGA , at 450 and 900 mg , on peak FMD response . However , there were significant improvements in mean post-ischaemic FMD response , particularly at the 1 h time point in this group of healthy individuals
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .