Multiple secondary data analyses of TORDIA have identified important predictors of treatment response and relapse .
To up date a comparative effectiveness review ( 1980–2011 ) of treatments for adolescents whose depressive episode or disorder ( MDE/MDD ) did not respond to one or more trials of SSRI antidepressants .
The Treatment of Adolescent Suicide Attempters study (TASA): predictors of suicidal events in an open treatment trial.
OBJECTIVE To identify the predictors of suicidal events and attempts in adolescent suicide attempters with depression treated in an open treatment trial . METHOD Adolescents who had made a recent suicide attempt and had unipolar depression ( n = 124 ) were either r and omized ( n = 22 ) or given a choice ( n = 102 ) among three conditions . Two participants withdrew before treatment assignment . The remaining 124 youths received a specialized psychotherapy for suicide attempting adolescents  ( n = 17 ) , a medication algorithm ( n = 14 ) , or the combination ( n = 93 ) . The participants were followed up 6 months after intake with respect to rate , timing , and predictors of a suicidal event ( attempt or acute suicidal ideation necessitating emergency referral ) . RESULTS The morbid risks of suicidal events and attempts on 6-month follow-up were 0.19 and 0.12 , respectively , with a median time to event of 44 days . Higher self-rated depression , suicidal ideation , family income , greater number of previous suicide attempts , lower maximum lethality of previous attempt , history of sexual abuse , and lower family cohesion predicted the occurrence , and earlier time to event , with similar findings for the outcome of attempts . A slower decline in suicidal ideation was associated with the occurrence of a suicidal event . CONCLUSIONS In this open trial , the 6-month morbid risks for suicidal events and for reattempts were lower than those in other comparable sample s , suggesting that this intervention should be studied further . Important treatment targets include suicidal ideation , family cohesion , and sequelae of previous abuse . Because 40 % of events occurred with 4 weeks of intake , an emphasis on safety planning and increased therapeutic contact early in treatment may be warranted
Multiple secondary data analyses of TORDIA have identified important predictors of treatment response and relapse .
To up date a comparative effectiveness review ( 1980–2011 ) of treatments for adolescents whose depressive episode or disorder ( MDE/MDD ) did not respond to one or more trials of SSRI antidepressants .