In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Dietary intake and major food sources of polyphenols in a Spanish population at high cardiovascular risk: the PREDIMED study.
BACKGROUND AND AIMS Epidemiological data have shown an inverse association between the consumption of polyphenol-rich foods and the risk of cardiovascular disease or overall mortality . A comprehensive estimation of individual polyphenol intake in nutritional cohorts is needed to gain a better underst and ing of this association . The aim of this study was to estimate the quantitative intake of polyphenols and the major dietary sources in the PREDIMED ( PREvención con DIeta MEDiterránea ) cohort using individual food consumption records . METHODS AND RESULTS The PREDIMED study is a large , parallel-group , multicentre , r and omised , controlled 5-year feeding trial aim ed at assessing the effects of the Mediterranean diet on the primary prevention of cardiovascular disease . A total of 7200 participants , aged 55 - 80 years , completed a vali date d 1-year food frequency question naire ( FFQ ) at baseline .  Polyphenol consumption was calculated by matching food consumption data from the FFQ with the recently developed Phenol-Explorer data base on polyphenol content in foods . The mean total polyphenol intake was 820 ± 323 mg day⁻¹ ( 443 ± 218 mg day⁻¹ of flavonoids and 304 ± 156 mg day⁻¹ of phenolic acids ) . Hydroxycinnamic acids were the phenolic group with the highest consumption and 5-caffeoylquinic acid was the most abundantly ingested individual polyphenol . The consumption of olives and olive oil was a differentiating factor in the phenolic profile of this Spanish population compared with other countries . CONCLUSION In Mediterranean countries , such as Spain , the main dietary source of polyphenols is coffee and fruits , but the most important differentiating factor with respect to other countries is the consumption of polyphenols from olives and olive oil
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .