No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .
Efficacy of topical azithromycin ophthalmic solution 1% in the treatment of posterior blepharitis
Introduction Azithromycin , a broad-spectrum antibiotic with potent anti-inflammatory activities , has the potential to effectively treat blepharitis , an inflammatory disease of the eyelid with abnormal eyelid flora as an etiologic determinant . The present study compared the efficacy of topical azithromycin ophthalmic solution 1 % ( AzaSite ® ; Inspire Pharmaceuticals , Inc , NC , USA ) combined with warm compresses ( azithromycin group ) to warm compresses alone ( compress group ) in patients with posterior blepharitis . Methods Twenty-one patients diagnosed with posterior blepharitis were r and omized in an open-label study to receive either azithromycin plus warm compresses ( 10 patients ) , or compresses alone ( 11 patients ) . All patients were instructed to apply compresses to each eye for 5–10 minutes twice daily for 14 days . Each eye in the azithromycin group also received azithromycin solution ( 1 drop ) twice daily for the first 2 days followed by once daily for the next 12 days . Patients were evaluated at study initiation ( visit 1 ) and at end of treatment ( visit 2 ) for the severity of five clinical signs : eyelid debris , eyelid redness , eyelid swelling , meibomian gl and ( MG ) plugging , and the quality of MG secretion . At visit 2 , patients also rated their degree of overall symptomatic relief . Results Twenty patients completed the study . At visit 2 , patients in the azithromycin group demonstrated significant improvements in MG plugging , MG secretions , and eyelid redness as compared with the compress group . In the azithromycin group , MG plugging resolved completely in three patients and MG secretion returned to normal in two patients ; no such results were seen in the compress group . Furthermore , a higher percentage of patients in the azithromycin group rated overall symptomatic relief as excellent or good . Visual acuity measurements and biomicroscopic evaluation revealed no ocular safety issues . Conclusion Azithromycin ophthalmic solution in combination with warm compresses provided a significantly greater clinical benefit than warm compresses alone in treating the signs and symptoms of posterior blepharitis
No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .