“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .
Pravastatin has an additional depressor effect in patients undergoing long-term treatment with antihypertensive drugs.
BACKGROUND Statins have been reported to have direct vascular effects independent of cholesterol reduction . To assess the antihypertensive effect of statins , a crossover study was design ed to compare the depressor effect of pravastatin and probucol in hypertensive patients undergoing long-term treatment with antihypertensive drugs . METHODS The subjects enrolled in this study were 52 hypertensive patients ( 22 men and 30 women , mean age 62.8 + /- 9.3 years ) who were treated with the same antihypertensive drugs for more than 1 year and had serum cholesterol levels of more than 5.69 mmol/L. In 26 subjects , pravastatin at a dose of 10 mg/d was given first for 6 months followed by treatment with probucol at a dose of 500 mg/d , and vice versa in the remaining 26 subjects . Serum lipids , apolipoproteins , glucose , and insulin were measured on the final day of the control period , and pravastatin and probucol treatments . The homeostatic model assessment insulin resistance index ( HOMA-IR ) was used to assess insulin resistance . RESULTS The blood pressure decreased after pravastatin treatment ( 141.2 + /- 4.7/81.3 + /- 4.9 to 136.5 + /- 5.3/80.6 + /- 5.1 mm Hg , P < .001/.499 ) , but did not decrease after probucol treatment ( 141.2 + /- 4.7/81.3 + /- 4.9 to 141.4 + /- 4.9/80.8 + /- 4.9 mm Hg , P = .832/.634 ) . Total cholesterol decreased significantly after pravastatin ( 6.69 + /- 0.69 to 5.23 + /- 0.77 mmol/L , P < .001 ) and probucol treatment ( 6.69 + /- 0.69 to 5.53 + /- 0.64 mmol/L , P < .001 ) . The HOMA-IR was decreased by probucol ( 1.92 + /- 0.78 to 1.57 + /- 0.59 , P = .029 ) , whereas pravastatin had no effect on HOMA-IR . CONCLUSIONS It can be concluded that the depressor effect of pravastatin may have an additional benefit in the treatment of hypertensive patients with hyperlipidemia without any adverse effect on insulin sensitivity
“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .