This meta- analysis suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-α
We conducted this systematic review and meta- analysis of prospect i ve studies to determine the effect of  probiotic administration on serum C-reactive protein ( CRP ) concentrations .
A prospective randomised study of the probiotic Lactobacillus plantarum 299V on indices of gut barrier function in elective surgical patients
Background : Bacterial translocation occurs in surgical patients and may predispose to postoperative septic morbidity . Many factors are thought to influence the prevalence of bacterial translocation , one of which is the composition of the gut microflora . The aim of this prospect i ve and r and omised study was to assess the effect of the probiotic Lactobacillus plantarum 299v on the incidence of bacterial translocation , gastric colonisation , and septic complications in elective surgical patients . Methods : Patients undergoing elective major abdominal surgery were r and omised to either a treatment or control group . The treatment group received an oral preparation containing Lactobacillus plantarum 299v ( Proviva ) for at least one week preoperatively and also in the postoperative period . Bacterial translocation was determined by culture of a mesenteric lymph node and serosal scraping obtained at laparotomy . Gastric colonisation was assessed by microbiological culture of nasogastric aspirates . All postoperative septic complications were recorded . Results : A total of 129 patients completed the study ( probiotic group n=64 ) . There was no significant difference between the two groups in terms of bacterial translocation ( 12 % v 12 % ; p=0.82 ) , gastric colonisation with enteric organisms ( 11 % v 17 % ; p=0.42 ) , or septic morbidity ( 13 % v 15 % ; p=0.74 ) . Conclusions : Administration of Lactobacillus plantarum 299v  in elective surgical patients does not influence the rate of bacterial translocation , gastric colonisation , or incidence of postoperative septic morbidity
This meta- analysis suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-α
We conducted this systematic review and meta- analysis of prospect i ve studies to determine the effect of  probiotic administration on serum C-reactive protein ( CRP ) concentrations .