There is no evidence that DHEA  improves quality of life but there is some evidence that it is associated with and rogenic side effects .
There is uncertainty whether DHEA decreases menopausal symptoms , but DHEA may slightly improve sexual function compared with placebo
BACKGROUND During menopause a decreasing ovarian follicular response generally causes a fluctuation and eventual decrease in estrogen levels .
This can lead to the development of various perimenopausal and postmenopausal symptoms ( for example hot flushes , night sweats , vaginal dryness ) .
Dehydroepi and rosterone ( DHEA ) is one of the main precursors of and rogens , which in turn are converted to testosterone and estrogens .
It is possible that the administration of DHEA may increase estrogen and testosterone levels in peri- and postmenopausal women to alleviate their symptoms and improve general wellbeing and sexual function ( for example libido , dyspareunia , satisfaction ) .
Treatment with DHEA is controversial as there is uncertainty about its effectiveness and safety .
This review should clearly outline the evidence for DHEA in the treatment of menopausal symptoms and evaluate its effectiveness and safety by combining the results of r and omised controlled trials .
OBJECTIVES To assess the effectiveness and safety of administering DHEA to women with menopausal symptoms in the peri- or postmenopausal phase .
Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy
Objective : Because the secretion of dehydroepi and rosterone ( DHEA ) , the exclusive source of sex steroids in postmenopausal women , is already decreased by 60 % and continues to decline at the time of menopause , the objective of this study was to examine the effect of intravaginal DHEA on the symptoms and signs of vaginal atrophy . Methods : This prospect i ve , r and omized , double-blind and placebo-controlled phase III clinical trial studied the effect of Prasterone ( DHEA ) applied locally in the vagina on the signs and symptoms of  vaginal atrophy in 216 postmenopausal women . Results : All three doses ( 0.25 % , 0.5 % , and 1.0 % ) of DHEA ovules applied daily intravaginally induced a highly significant beneficial change in the percentage of vaginal parabasal and superficial cells and pH as well as in the most bothersome symptom at 2 weeks . At the st and ard 12-week time interval , 0.5 % DHEA caused a 45.9 ± 5.31 ( P < 0.0001 vs placebo ) decrease in the percentage of parabasal cells , a 6.8 ± 1.29 % ( P < 0.0001 ) increase in superficial cells , a 1.3 ± 0.13 unit ( P < 0.0001 ) decrease in vaginal pH , and a 1.5 ± 0.14 score unit ( P < 0.0001 ) decrease in the severity of the most bothersome symptom . Similar changes were seen on vaginal secretions , color , epithelial surface thickness , and epithelial integrity . Comparable effects were observed at the 0.25 % and 1.0 % DHEA doses . Conclusions : Local Prasterone , through local and rogen and estrogen formation , causes a rapid and efficient reversal of all the symptoms and signs of vaginal atrophy with no or minimal changes in serum steroids , which remain well within the normal postmenopausal range . This approach avoids the fear of systemic effects common to all presently available estrogen formulations and adds a novel physiological and rogenic component to therapy
There is no evidence that DHEA  improves quality of life but there is some evidence that it is associated with and rogenic side effects .
There is uncertainty whether DHEA decreases menopausal symptoms , but DHEA may slightly improve sexual function compared with placebo
BACKGROUND During menopause a decreasing ovarian follicular response generally causes a fluctuation and eventual decrease in estrogen levels .
This can lead to the development of various perimenopausal and postmenopausal symptoms ( for example hot flushes , night sweats , vaginal dryness ) .
Dehydroepi and rosterone ( DHEA ) is one of the main precursors of and rogens , which in turn are converted to testosterone and estrogens .
It is possible that the administration of DHEA may increase estrogen and testosterone levels in peri- and postmenopausal women to alleviate their symptoms and improve general wellbeing and sexual function ( for example libido , dyspareunia , satisfaction ) .
Treatment with DHEA is controversial as there is uncertainty about its effectiveness and safety .
This review should clearly outline the evidence for DHEA in the treatment of menopausal symptoms and evaluate its effectiveness and safety by combining the results of r and omised controlled trials .
OBJECTIVES To assess the effectiveness and safety of administering DHEA to women with menopausal symptoms in the peri- or postmenopausal phase .