RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .
Comparison of candesartan with lisinopril on ambulatory blood pressure and morning surge in patients with systemic hypertension.
We performed a prospect i ve crossover study in 73 essential hypertensives to compare the effects of c and esartan and lisinopril on ambulatory blood pressure ( BP ) and early-morning BP . Twenty-four-hour ambulatory BP monitoring was performed at baseline and for each active treatment . Small doses of thiazide diuretic were added as needed . The effects of both drugs on 24-hour BP were almost identical and satisfactory . When we classified patients into the morning surge group ( the highest quartile of morning systolic BP surge > 36 mm Hg ) and the non-morning surge group ( the remaining 3 quartiles of morning BP surge ) , c and esartan was superior in decreasing morning BP and morning BP surge
RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .