Conclusion Patients with an AHRE burden over 6 min have an increased risk for stroke .
Aims Atrial fibrillation ( AF ) patients have increased risk of stroke .
In paroxysmal AF , the combination of duration and frequency of episodes defines AF burden .
In patients with cardiac implantable electronic devices ( CIEDs ) , atrial high-rate episodes ( AHREs ) can be monitored continuously and are considered as a proxy for AF .
This systematic review aims to determine the relationship between AF burden and risk of thrombo-embolic events ( TBEs ) .
Potential value of automated daily screening of cardiac resynchronization therapy defibrillator diagnostics for prediction of major cardiovascular events: results from Home-CARE (Home Monitoring in Cardiac Resynchronization Therapy) study
Aim To investigate whether diagnostic data from implanted cardiac resynchronization therapy defibrillators ( CRT-Ds ) retrieved automatically at 24 h intervals via a Home Monitoring function can enable dynamic prediction of cardiovascular hospitalization and death . Methods and results Three hundred and seventy-seven heart failure patients received CRT-Ds with Home Monitoring option .  Data on all deaths and hospitalizations due to cardiovascular reasons and Home Monitoring data were collected prospect ively during 1-year follow-up to develop a predictive algorithm with a predefined specificity of 99.5 % . Seven parameters were included in the algorithm : mean heart rate over 24 h , heart rate at rest , patient activity , frequency of ventricular extrasystoles , atrial – atrial intervals ( heart rate variability ) , right ventricular pacing impedance , and painless shock impedance . The algorithm was developed using a 25-day monitoring window ending 3 days before hospitalization or death . While the retrospective sensitivities of the individual parameters ranged from 23.6 to 50.0 % , the combination of all parameters was 65.4 % sensitive in detecting cardiovascular hospitalizations and deaths with 99.5 % specificity ( corresponding to 1.83 false-positive detections per patient-year of follow-up ) . The estimated relative risk of an event was 7.15-fold higher after a positive predictor finding than after a negative predictor finding . Conclusion We developed an automated algorithm for dynamic prediction of cardiovascular events in patients treated with CRT-D devices capable of daily transmission of their diagnostic data via Home Monitoring . This tool may increase patients ’ quality of life and reduce morbidity , mortality , and health economic burden , it now warrants prospect i ve studies . Clinical Trials.gov NCT00376116
Conclusion Patients with an AHRE burden over 6 min have an increased risk for stroke .
Aims Atrial fibrillation ( AF ) patients have increased risk of stroke .
In paroxysmal AF , the combination of duration and frequency of episodes defines AF burden .
In patients with cardiac implantable electronic devices ( CIEDs ) , atrial high-rate episodes ( AHREs ) can be monitored continuously and are considered as a proxy for AF .
This systematic review aims to determine the relationship between AF burden and risk of thrombo-embolic events ( TBEs ) .