The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .
Efficacy of losartan and carvedilol on central hemodynamics in hypertensives: a prospective, randomized, open, blinded end point, multicenter study
Renin – angiotensin system ( RAS ) blockers have shown clinical outcomes superior to those of the beta (β)-blocker atenolol , despite similar reductions in the peripheral blood pressure ( BP ) , perhaps because of different impacts on central hemodynamics . However , few comparative studies of RAS blockers and newer vasodilating β-blockers have been performed . We compared the central hemodynamic effects of losartan and carvedilol in a prospect i ve , r and omized , open , blinded end point study . Of the 201 hypertensive patients enrolled , 182 ( 49.6±9.9 years , losartan group=88 and carvedilol group=94 ) were analyzed . Carotid-femoral pulse wave velocity ( cfPWV ) , aortic augmentation index ( AIx ) , AIx corrected for a heart rate ( HR ) of 75 beats per minute ( AIx@HR75 ) and central BP were measured noninvasively at baseline and after a 24-week treatment regimen with losartan or carvedilol . After 24 weeks , there were no between-group differences in the brachial BP , cfPWV , AIx@HR75 or central BP changes , except for a more favorable AIx effect with losartan . The changes in all measured metabolic and inflammatory parameters were also not significantly different between the two groups , except for uric acid . Losartan and carvedilol showed generally comparable effects on central hemodynamic indices , metabolic profile , inflammatory parameters and peripheral arterial pressure with a 24-week treatment
The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .