At the time of this review , seven AAPs were available in Canada : aripiprazole clozapine olanzapine paliperidone quetiapine risperidone ziprasidone
Schizophrenia is a mental illness that requires lifelong treatment and is associated with symptoms that include hallucinations , delusions , cognitive impairment , disorganized thoughts , social withdrawal , and low motivation .
Antipsychotic medications are effective at relieving the symptoms of schizophrenia , and they form the foundation of treatment .
Risperidone versus haloperidol in the treatment of chronic schizophrenic inpatients: a multicentre double‐blind comparative study
Forty‐four chronic schizophrenic in patients participated in this multicentre 12‐week parallel‐group double‐blind trial . After a run‐in period of 2 weeks and a single‐blind placebo wash‐out of 1 week , they were r and omly assigned to treatment with either the serotonin2 and dopamine‐D2 antagonist risperidone or haloperidol .  Two patients were excluded from the efficacy analysis . Five patients dropped out in the haloperidol group and 1 in the risperidone group . At the end of the trial , the mean daily dose was 12 mg for risperidone and 10 mg for haloperidol . The risperidone group showed greater improvement on the Positive and Negative Syndrome Scale for Schizophrenia , the Schedule for Affective Disorders and Schizophrenia – change version , and the Nurses ’ Observation Scale for Inpatient Evaluation . The improvement of negative symptoms was more pronounced in the risperidone group until week 8 of double‐blind treatment . The consumption of antiparkinsonian medication was 10 times lower with risperidone . Both drugs were well tolerated and the laboratory , endocrinological and cardiovascular safety parameters were comparable . This study suggests that risperidone is comparable to haloperidol as an antipsychotic , but that it has a safer EPS profile
At the time of this review , seven AAPs were available in Canada : aripiprazole clozapine olanzapine paliperidone quetiapine risperidone ziprasidone
Schizophrenia is a mental illness that requires lifelong treatment and is associated with symptoms that include hallucinations , delusions , cognitive impairment , disorganized thoughts , social withdrawal , and low motivation .
Antipsychotic medications are effective at relieving the symptoms of schizophrenia , and they form the foundation of treatment .