Results : We confirmed the importance of the 4 main factors influencing SC : ( 1 ) environmental factors , ( 2 ) genomic factors , ( 3 ) gene-environment interactions , and ( 4 ) evidence -based interventions .
The model demonstrates the complex network of factors influencing SC .
Background : Smoking behaviour is a major public health problem worldwide .
Several sources have confirmed the implication of genomic factors in smoking behaviour .
These factors interact both with environmental factors and interventions to develop a certain behaviour .
Objectives : Describing the environmental and genomic factors as well as the interventions influencing smoking cessation  ( SC ) and developing a working model incorporating the different factors influencing SC were our main objectives .
The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trial.
In this follow-up of a r and omized placebo-controlled clinical trial of nicotine replacement transdermal patch for smoking cessation , 741 smokers of European ancestry who were r and omized to receive active patch or placebo patch  were genotyped for the serotonin transporter gene-linked polymorphic region . The study setting was a primary care research network in Oxfordshire , United Kingdom . The primary outcome measures were biochemically verified sustained abstinence from cigarette smoking at end of treatment and 24-week follow-up . The main effect of genotype was not associated with sustained abstinence from smoking at either end of treatment ( SL : p=.33 ; SS : p=.81 ) or 24-week follow-up ( SL : p=.05 ; SS : p=.21 ) , and we found no evidence for a genotypextreatment interaction effect . In summary , despite the theoretically important contribution of serotonin neurotransmission to smoking cessation , the serotonin transporter gene was not associated with treatment response to nicotine patch for smoking cessation in this primary care-based trial
Results : We confirmed the importance of the 4 main factors influencing SC : ( 1 ) environmental factors , ( 2 ) genomic factors , ( 3 ) gene-environment interactions , and ( 4 ) evidence -based interventions .
The model demonstrates the complex network of factors influencing SC .
Background : Smoking behaviour is a major public health problem worldwide .
Several sources have confirmed the implication of genomic factors in smoking behaviour .
These factors interact both with environmental factors and interventions to develop a certain behaviour .
Objectives : Describing the environmental and genomic factors as well as the interventions influencing smoking cessation  ( SC ) and developing a working model incorporating the different factors influencing SC were our main objectives .