The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
Triclosan/pyrophosphate dentifrice: dental plaque and gingivitis effects in a 6-month randomized controlled clinical study.
A double-blind , parallel , r and omized and controlled clinical trial was conducted on 186 subjects over six months to assess the effects of a 0.28 % triclosan/5 % pyrophosphate ( with NaF/silica ) dentifrice on dental plaque and gingivitis as compared to a NaF/silica negative control dentifrice . An initial examination was performed to assess the health of the oral soft and hard tissues and to measure plaque ( by Turesky modified Quigley-Hein Plaque Index ) , gingivitis ( by Löe-Silness Gingival and Ainamo and Bay Gingival Bleeding [ GBI ] indices ) .  Only those subjects with a GBI score > or = 5 were accepted into the study . Each enrolled subject received an oral prophylaxis and was requested to brush and floss twice per day with the negative control NaF/silica dentifrice . After one month , the subjects were recalled and a baseline examination was performed for each of the previously described parameters . Following the baseline examination , the subjects received another oral prophylaxis . The subjects were then separated by gender and by baseline GBI scores of < or = 7 or > 7 and arrayed by the changes in GBI bleeding sites from initial to baseline . Within strata , subjects were r and omly assigned to brush twice per day with either the triclosan/pyrophosphate dentifrice or the negative control dentifrice . The subjects were subsequently examined for all of the above-described parameters following use of the test dentifrices for five weeks , three and six months . The data generated in this trial were analyzed using an analysis of covariance on all indices for all subjects completing the examinations . The results from this study demonstrated that the use of the triclosan/pyrophosphate dentifrice result ed in statistically significant reductions of dental plaque compared to the control by 10 % ( p < 0.05 ) , 15.4 % ( p < 0.01 ) and 13.9 % ( p < 0.01 ) at five weeks , three and six months , respectively . However , there were no statistically significant differences between the test dentifrices for any of the gingivitis or gingival bleeding evaluations throughout the study . Based on 1 ) the fact that subjects possessed plaque-induced gingivitis in this clinical study , 2 ) the similarity in the magnitude of the plaque reductions observed from the triclosan/pyrophosphate dentifrice relative to those reported for other triclosan-containing dentifrices , 3 ) the similarity in the dose of triclosan relative to other triclosan dentifrices , and 4 ) the reported magnitude of gingivitis reductions from other triclosan-containing dentifrices , these findings were unexpected . Possible explanations of these results are that the triclosan/pyrophosphate dentifrice may be uniquely different from other triclosan dentifrices relative to its effects on gingivitis , or alternatively , the clinical design utilized here may not be optimized for triclosan/pyrophosphate dentifrice
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .