Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .
Structural and energetic processes related to P300: LORETA findings in depression and effects of antidepressant drugs.
Noninvasive electrophysiological neuroimaging applied to cognitive components of event-related potentials ( ERPs ) may differentiate between structural and energetic processes related to information processing . The structural level , revealed by the location of the local maxima of the current source density distribution , describes the time-dependent network of activated brain areas . The magnitude of the source strength , a measure of the energetic component , describes the allocation of processing re sources . ERPs were recorded in an odd-ball paradigm and low-resolution brain electromagnetic tomography ( LORETA ) was applied for st and ard and target ERP components . In a group of 60 menopausal depressed patients of 45 - 60 years of age , reduced P300 source strength was observed bilaterally , temporally and medially prefrontally reaching to rostal parts of the anterior cingulate , compared with 29 age-matched controls . In a double-blind , placebo-controlled study , 2 mg of the antidepressant citalopram induced a significant increase of P300 source strength in the ( left ) prefrontal cortex and precuneus compared with placebo , reaching to the posterior cingulate . Similar increases were observed after 800 mg S-adenosyl-L-methionine ( SAMe ) administered intravenously in ten young healthy subjects aged 22 - 33 , and they were even more pronounced in ten elderly healthy subjects aged 56 - 71 . Thus , ERP-tomography identified changes in energetic sources in brain areas predominantly involved in depression and in antidepressant action
Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .