Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects
Background / Objectives : Coffee is known to contain antioxidant substances whose effects may be blunted because of caffeine that may unfavorably affect the cardiovascular system . This study was design ed to investigate the acute dose-dependent effects of decaffeinated coffee ( DC ) on endothelial function measured by the brachial artery flow-mediated dilation (FMD).Subjects/ Methods : A total of 15 ( 8 men and 7 women ) healthy nonobese subjects underwent a single-blind , crossover study . Subjects ingested one and two cups of decaffeinated Italian espresso coffee in r and om order at 5- to 7-day intervals . Results : In the hour following the ingestion of two cups of DC  , FMD increased ( mean±s.e.m . ) : 0 min , 7.4±0.7 % ; 30 min , 8.0±0.6 % ; 60 min , 10.8±0.8 % ; P<0.001 ) as compared to consumption of one cup of DC ( 0 min , 6.9±0.7 % ; 30 min , 8.4±1.2 % ; 60 min , 8.5±1.1 % ; 3 × 2 repeated- measures analysis of variance : P=0.037 for time × treatment effect ) . Blood pressure did not differ between groups , and basal heart rate was lower in the two-cup group at baseline and 60 min . Conclusions : The present study demonstrated a significant acute favorable dose-dependent effect of decaffeinated espresso coffee  on endothelial function . Further studies are needed to investigate the effects of chronic use of DC especially with respect to caffeinated coffee and in subjects with cardiovascular diseases
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .