When comparing NNS vs sucrose , significant weight/ BMI differences appeared favouring NNS .
Consumption of NNS led to significantly negative weight/ BMI differences in unrestricted energy diets , but not in weight-reduction diets .
Participants with overweight/obesity and adults showed significant favourable weight/ BMI differences with NNS .
Data suggest that replacing sugar with NNS leads to weight reduction , particularly in participants with overweight/obesity under an unrestricted diet , information that could be utilized for evidence -based public policy decisions
There is an ongoing debate about the possible influences of nonnutritive sweeteners ( NNS ) on body weight .
We conducted a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) with NNS to assess their impact on body weight .
Use of aspartame by apparently healthy children and adolescents.
This study was conducted to determine the effects and the differences , if any , result ing from the ingestion of aspartame ( sweetener ) versus sucrose . A 13-wk , double-blind study was conducted using 126 apparently healthy children and adolescents as panelists . Individuals were r and omly assigned in a double-blind design to aspartame or sucrose in each of five age groups ; dosage levels were assigned according to age and weight groups . Physical examinations and special eye examinations were performed at the beginning and end of the study . Other parameters determined including laboratory tests of liver and renal function , hematologic status , and plasma levels of phenylalanine and tyrosine . Clinical ly significant differences in laboratory parameters measured could not be demonstrated ; all mean values were within normal limits . No unusual findings were observed in phenylalanine or tyrosine levels . All phenylpyruvic acid and methanol determinations were negative . No important physical changes occurred , and no product-related side effects were reported
When comparing NNS vs sucrose , significant weight/ BMI differences appeared favouring NNS .
Consumption of NNS led to significantly negative weight/ BMI differences in unrestricted energy diets , but not in weight-reduction diets .
Participants with overweight/obesity and adults showed significant favourable weight/ BMI differences with NNS .
Data suggest that replacing sugar with NNS leads to weight reduction , particularly in participants with overweight/obesity under an unrestricted diet , information that could be utilized for evidence -based public policy decisions
There is an ongoing debate about the possible influences of nonnutritive sweeteners ( NNS ) on body weight .
We conducted a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) with NNS to assess their impact on body weight .