Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .
Comparison of Pueraria mirifica 25 and 50 mg for menopausal symptoms
Purpose To compare Pueraria mirifica 25 and 50 mg dosages to relieve menopausal symptoms . Methods A double-blind study was conducted on 52 hysterectomized women with menopausal symptoms who had an indication for hormone therapy . The women were r and omly allocated into two groups receiving either Pueraria mirifica 25 mg tablet ( Arm A ; n = 26 ) or Pueraria mirifica 50 mg ( Arm B ; n = 26 ) for 6 months . Menopausal symptoms , physical examination findings , and laboratory data were recorded at baseline . Symptoms were reevaluated at 3 and 6 months , while physical and laboratory examinations were evaluated at 1 month and at the end of treatment . A modified Green climacteric scale was used to evaluate menopausal symptoms ; a score of ≥15 indicated estrogen deficiency . Results All women completed the study . Mean baseline climacteric scores of women who received 25 and 50 mg were : 24.19 ± 9.11 versus 23.19 ± 7.89 , respectively ( p = 0.674 ) . After 3 and 6 months of treatment , scores were 17.92 ± 10.40 versus 15.35 ± 8.44 ( p = 0.332 ) and 14.08 ± 10.30 versus 12.46 ± 6.38 ( p = 0.500 ) , respectively . No significant side effects were observed with Pueraria mirifica 25 or 50 mg . Conclusions Both dosages of Pueraria mirifica were similarly effective and safe in the treatment of menopausal symptoms
Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .