Conclusions No conclusive recommendations were possible due to wide variation in study quality , method ologies and outcome measures .
A synthesis of available literature suggests that treatments containing urea as a primary active ingredient have been the most research ed .
Background Xerosis , literally dryness of the skin , of the foot is a common condition encountered clinical ly , which can lead to discomfort and predisposition to infection .
Currently , there are no evidence -based recommendations on which moisturiser formulations best alleviate xerotic symptoms .
The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis , by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population .
A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis.
Xerotic skin is a pattern of reaction to a variety of disorders ( eg , winter xerosis , hereditary ichthyosis ) with abnormalities of desquamation in common . The trial described in this article was a double-blind r and omized-comparison clinical trial investigating the effect of pure lanolin versus ammonium lactate 12 % cream in treating moderate to severe foot xerosis . Xerosis was clinical ly assessed at baseline visit , and design ated sites were reevaluated after 1 , 2 , and 4 weeks of therapy . Ninety-two patients were enrolled ; 41 of these were excluded from analysis ( 25 were lost to follow-up , 8 were noncompliant , 1 was discharged from study because of an adverse event after visit 1 , and 7 were noncompliant after visit 2 ) . Although there was significant improvement in xerosis scores for both treatment groups after 2 and 4 weeks of treatment , no differences were statistically significant . Used twice daily for 4 weeks , pure lanolin and ammonium lactate cream were both effective in treating moderate to severe xerosis
Conclusions No conclusive recommendations were possible due to wide variation in study quality , method ologies and outcome measures .
A synthesis of available literature suggests that treatments containing urea as a primary active ingredient have been the most research ed .
Background Xerosis , literally dryness of the skin , of the foot is a common condition encountered clinical ly , which can lead to discomfort and predisposition to infection .
Currently , there are no evidence -based recommendations on which moisturiser formulations best alleviate xerotic symptoms .
The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis , by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population .