The results of meta- analysis showed statistically significant differences between aloe vera and control groups in alleviating pain/burning sensation at the end of the first and second month , in favor of aloe vera , but no significant differences were found at the end of the third month .
With regard to objective clinical outcomes , no statistically significant differences were found between the groups .
Aloe vera has a promising effect in reducing pain/burning sensation and clinical improvement in patients with OSF .
The management of oral submucous fibrosis ( OSF ) is quite challenging , and as yet , no effective therapy is available for its management .
The present systematic review and meta- analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF .
Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study.
OBJECTIVE To investigate the effectiveness of turmeric with black pepper and nigella sativa in oral submucous fibrosis ( OSMF ) . STUDY DESIGN Forty OSMF patients were r and omly divided into two groups . The study was performed under a double-blind , r and omized design . Group A received turmeric with black pepper and group B received nigella sativa for 3 months .  Clinical evaluation was done every 15 days . Patients ' serum superoxide dismutase ( SOD ) levels were assessed before and after treatment and also compared with healthy controls . The response to treatment was analyzed using analysis of variance , paired t test , and unpaired t test . RESULTS After the treatment , groups A and B showed 3.85 ± 0.22 mm and 3.6 ± 0.07 mm improvement in mouth opening , respectively ( P < .01 ) ; 87.90 % and 78.91 % reduction in burning sensation , respectively ( P < .01 ) ; and + 0.62 U/mL and + 0.74 U/mL improvement in serum SOD levels , respectively ( P < .05 ) . The maximum mouth opening achieved was 8 mm in group A and 7 mm in group B. The mean pretreatment SOD level for controls and patients was 3.61 ± 0.24 U/mL in group A and 2.63 ± 0.18 U/mL in group B. CONCLUSION Turmeric with black pepper and nigella sativa  improved mouth opening , burning sensation , and SOD levels in the present OSMF study patients ; however , further investigations are needed
The results of meta- analysis showed statistically significant differences between aloe vera and control groups in alleviating pain/burning sensation at the end of the first and second month , in favor of aloe vera , but no significant differences were found at the end of the third month .
With regard to objective clinical outcomes , no statistically significant differences were found between the groups .
Aloe vera has a promising effect in reducing pain/burning sensation and clinical improvement in patients with OSF .
The management of oral submucous fibrosis ( OSF ) is quite challenging , and as yet , no effective therapy is available for its management .
The present systematic review and meta- analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF .