REVIEW ER 'S CONCLUSIONS There is no evidence to support feeding with a hydrolysed formula for the prevention of allergy in preference to exclusive breast feeding .
In high risk infants who are unable to be completely breast fed , there is evidence that prolonged feeding with a hydrolysed compared to a cow 's milk formula reduces infant and childhood allergy and infant CMA .
BACKGROUND Allergies and food reactions are common and may be associated with foods including adapted cow 's milk formulas .
Formulas containing hydrolysed proteins have been used to treat infants with allergy or food intolerance , and have been advocated for prevention of allergy and food intolerance in infants .
OBJECTIVES To determine whether use of hydrolysed formulas for infant feeding prevents allergy and food intolerance .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective including extensively and partially hydrolysed formulas .
To determine which infants benefit including infants at low or high risk of allergy and infants receiving early , short term or prolonged formula feeding .
Incidence and prevalence of asthma among adult Finnish men and women of the Finnish Twin Cohort from 1975 to 1990, and their relation to hay fever and chronic bronchitis.
STUDY OBJECTIVES To examine the prevalence of asthma and hay fever  , and the incidence and temporal relationships of asthma , hay fever , and chronic bronchitis  among adult twins during a 15-year period . DESIGN Prospect i ve cohort study . PARTICIPANTS A population of 11,540 Finnish adult men and women , initially 18 to 45 years of age , who returned a health question naire in 1975 , 1981 , and 1990 as part of the Finnish Twin Cohort study . METHODS Age-st and ardized prevalences and cumulative incidences among individuals were calculated for asthma , hay fever , and chronic bronchitis . The incidence of asthma among subjects with and without hay fever or chronic bronchitis was analyzed in the entire cohort as well as in twin pairs discordant for incident asthma . RESULTS The prevalence of asthma increased slightly from 1975 ( 2.0 % in men and 2.2 % in women ) to 1990 ( 2.9 % in men and 3.1 % in women ) . The prevalence of hay fever showed a larger increase in men and women ( from 6.8 % and 9.8 % to 11.8 % and 15.3 % , respectively ) . Compared with figures for 1976 to 1981 , no significant increase in asthma incidence occurred from 1982 to 1990 , whereas the incidence of hay fever was lower during the latter period among men ( incidence rate ratio , 0.7 ; 95 % confidence interval , 0.6 to 0.9 ) as was the incidence of chronic bronchitis among women ( incidence rate ratio , 0.7 ; 95 % confidence interval , 0.6 to 0.9 ) . Hay fever and chronic bronchitis were usually diagnosed before asthma . Both diseases increased the risk of asthma significantly on the basis of analyses of all individuals and of discordant twin pairs . CONCLUSIONS The pattern of increase in asthma and hay fever prevalence with time was similar , and hay fever was a strong predictor of asthma . These diseases showed no significant increase in incidence
REVIEW ER 'S CONCLUSIONS There is no evidence to support feeding with a hydrolysed formula for the prevention of allergy in preference to exclusive breast feeding .
In high risk infants who are unable to be completely breast fed , there is evidence that prolonged feeding with a hydrolysed compared to a cow 's milk formula reduces infant and childhood allergy and infant CMA .
BACKGROUND Allergies and food reactions are common and may be associated with foods including adapted cow 's milk formulas .
Formulas containing hydrolysed proteins have been used to treat infants with allergy or food intolerance , and have been advocated for prevention of allergy and food intolerance in infants .
OBJECTIVES To determine whether use of hydrolysed formulas for infant feeding prevents allergy and food intolerance .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective including extensively and partially hydrolysed formulas .
To determine which infants benefit including infants at low or high risk of allergy and infants receiving early , short term or prolonged formula feeding .