Results showed no significant effects on core symptomatology .
In conclusion , up to date , evidence regarding the potential utility of IN-OT in treating anxiety and depression is still inconclusive .
Several studies have demonstrated the neuromodulating function of oxytocin ( OT ) in response to anxiogenic stimuli as well as its potential role in the pathogenesis of depression .
Consequently , intranasal OT ( IN-OT ) has been proposed as a potential treatment of  anxiety and depressive disorders .
The present systematic review aim ed to summarize the r and omized controlled trials ( RCTs ) evaluating the effect of IN-OT on anxiety and depressive symptoms .
The Effects of Intranasal Oxytocin Administration on Sensitive Caregiving in Mothers with Postnatal Depression
Postnatal depression ( PND ) is common and negatively affects the mother – infant relationship ; oxytocin ( OT ) has been found to have positive effects on parenting , although psychiatric disorders may reduce these effects . Thus , we explored the role of OT in mothers diagnosed with PND . A within-subject , r and omized controlled double-blind design was used to test the effects of nasal administration of OT or placebo on sensitive caregiving . The outcome measures were perceptual and caregiving responses to prerecorded cry sounds , as well as observed maternal sensitivity . We found that in the OT condition mothers with PND were more likely to rate an infant cry as more urgent and they were more likely to indicate they would chose a harsh caregiving strategy in response . There was no effect of OT on maternal sensitive interaction with their own baby . Further research is required prior to consideration of OT administration in depressed mothers of infants
Results showed no significant effects on core symptomatology .
In conclusion , up to date , evidence regarding the potential utility of IN-OT in treating anxiety and depression is still inconclusive .
Several studies have demonstrated the neuromodulating function of oxytocin ( OT ) in response to anxiogenic stimuli as well as its potential role in the pathogenesis of depression .
Consequently , intranasal OT ( IN-OT ) has been proposed as a potential treatment of  anxiety and depressive disorders .
The present systematic review aim ed to summarize the r and omized controlled trials ( RCTs ) evaluating the effect of IN-OT on anxiety and depressive symptoms .