We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
The prevalence and natural course of food protein-induced enterocolitis syndrome to cow's milk: a large-scale, prospective population-based study.
BACKGROUND The prevalence and natural history for food protein-induced enterocolitis syndrome ( FPIES ) have not been determined . OBJECTIVE We sought to determine the prevalence , clinical manifestations , and rate of recovery for FPIES in a large-scale , population -based prospect i ve study . METHODS In a prospect i ve study the feeding history of 13,019 infants was obtained . Infants with probable adverse reactions to cow 's milk protein ( CMP )  were clinical ly examined , skin prick tested , and challenged orally . Diagnostic criteria for CMP-induced FPIES included age less than 9 months , delayed recurrent vomiting ( usually with nausea ) , and lethargy after exposure to CMP in the absence of other IgE-mediated symptoms , such as rash , urticaria , and respiratory symptoms . In addition , a positive challenge response to milk result ed in the above-mentioned gastrointestinal symptoms , removal of milk from the diet result ed in the resolution of those symptoms , or both . RESULTS Ninety-eight percent of the cohort participated in the study . The cumulative incidence for FPIES was 0.34 % ( 44/13,019 patients ) . The most common symptoms were recurrent vomiting ( 100 % ) , lethargy ( 77 % ) diarrhea ( 25 % ) , pallor ( 14 % ) , and bloody diarrhea ( 4.5 % ) . All patients had FPIES  within the first 6 months of life . By the age of 3 years , 90 % of the patients had recovered . We did not detect any concomitant reaction to soy . Eight patients with FPIES had IgE-mediated cow 's milk allergy ( IgE-CMA ) . CONCLUSIONS The prevalence of FPIES is significant , and its clinical presentation is distinct from that of IgE-CMA . Most patients with FPIES recover , although a proportion might convert to IgE-CMA . The likelihood for a cross-reactivity to soy in this population was less than previously estimated
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .