Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .
[Efficiency and safety of citalopram and venlafaxine in treatment of depressive disorders in elderly patients].
UNLABELLED Depressive disorders in people older than 65 years seem to be a serious medical and social problem in many countries . The aim of the study was to evaluate efficiency and safety of citalopram and venlafaxine in treatment of depression in elderly patients . MATERIAL AND METHODS 89 elderly patients with a serious depressive episode were involved in the study . Observation was carried out for 42 days . The clinical state of patients was assessed by Hamilton rating scale ( HAM-D ) , a geriatric depressive scale ( GDS ) and a clinical general impression scale ( CGI ) . Cognitive functions were examined by Mini-Mental scale . 44 patients took citalopram , and 45 patients took venlafaxine . RESULTS On the 42nd day of treatment , citalopram therapy appeared successful in 34 ( 77.3 % ) patients , while venlafaxine therapy was successful in 30 ( 66.6 % ) patients . Citalopram was significantly more efficient than venlafaxine during the first 21 and 28 days of treatment . Neither drug caused disturbances of cognitive functions in the examined groups . CONCLUSIONS 1 . Citalopram and venlafaxine are similarly efficient in treatment of depressive disorders and are well tolerated by elderly patients . 2 . The onset of therapeutic activity of citalopram is potentially faster in depressive patients older than 65 years
Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .