However , benefit was limited to antipsychotics and tricyclic antidepressants .
Conclusions Psychotropic drugs may be an effective treatment for FD , but the effect appears to be limited to antipsychotics and tricyclic antidepressants with fewer trials for other agents , meaning that firm conclusions for efficacy can not be made .
Objective Functional dyspepsia ( FD ) is a chronic gastroduodenal disorder .
Individuals with FD demonstrate visceral hypersensitivity , abnormal central pain processing , and low mood , but it is unclear whether psychotropic drugs are an effective treatment for the condition .
Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study.
BACKGROUND & AIMS Functional gastrointestinal disorders ( FGID ) are common in the community . The natural history of FGID is unknown because of a lack of prospect i ve population -based studies and the indistinct nature of the phenotype . We sought to report the natural history of FGID in a US population . METHODS This prospect i ve cohort study used data from multiple vali date d surveys of r and om sample s of Olmsted County , MN , residents over a mean of a 12-year period between 1988 and 2003 ( n = 1365 ) . The surveys measured gastrointestinal symptoms experienced during the past year . Each subject received a minimum of 2 surveys . Point prevalence , onset , and disappearance rates and transition probabilities were calculated for individual FGIDs . RESULTS Between the initial and final surveys , the point prevalences ( per 100 residents ) were stable for irritable bowel syndrome ( 8.3 % and 11.4 % , respectively ) and functional dyspepsia ( 1.9 % and 3.3 % , respectively ) . The onset of each of the disorders studied was greater than the disappearance rate , but the transition probabilities varied across the different subgroups . Among people with symptoms at baseline , approximately 20 % had the same symptoms , 40 % had no symptoms , and 40 % had different symptoms at follow-up . CONCLUSIONS Although the prevalence of the FGID was stable over time , the turnover in symptom status was high . Many episodes of symptom disappearance were due to subjects changing symptoms rather than total symptom resolution . This transition between different FGIDs suggests a common etiopathogenesis
However , benefit was limited to antipsychotics and tricyclic antidepressants .
Conclusions Psychotropic drugs may be an effective treatment for FD , but the effect appears to be limited to antipsychotics and tricyclic antidepressants with fewer trials for other agents , meaning that firm conclusions for efficacy can not be made .
Objective Functional dyspepsia ( FD ) is a chronic gastroduodenal disorder .
Individuals with FD demonstrate visceral hypersensitivity , abnormal central pain processing , and low mood , but it is unclear whether psychotropic drugs are an effective treatment for the condition .