Furthermore , this therapy could increase the dem and on radiation re sources .
There is no evidence on which to make a recommendation for patients with node-negative tumours that have not penetrated the muscularis propria .
For patients unable to undergo radiation , adjuvant chemotherapy alone may be of benefit , particularly for those with lymph-node metastases .
There is insufficient evidence from r and omized trials to recommend neoadjuvant chemotherapy , or neoadjuvant or adjuvant radiotherapy or immunotherapy , either alone or in combination , outside a clinical trial .
OBJECTIVE To make recommendations on the use of neoadjuvant or adjuvant therapy in addition to surgery in patients with resectable gastric cancer ( T1 - 4 , N1 - 2 , M0 ) .
OPTIONS Neoadjuvant or adjuvant treatments compared with " curative " surgery alone .
OUTCOMES Overall survival , disease-free survival , and adverse effects .
The radiation fields used can possibly damage the left kidney , result ing in hypertension and other renal problems .
[Evaluation of postoperative immunotherapy of gastric cancer].
In order to evaluate the clinical effectiveness of immunotherapy on gastric cancer patients , we performed two controlled trials of immunotherapy with BCG-CWS and Nocardia rubra CWS respectively . A controlled trial of BCG-CWS was performed from 1976 to 1978 . The result showed an improved survival rate of the immunotherapy as compared with the chemotherapy group . From September 1979 through March 1981 , a total of 302 patients with gastric cancer undergoing gastrectomy at the Department of Surgery , Chiba University Hospital and its 14 affiliated hospitals were studied for clinical effectiveness of immunotherapy with N-CWS . The subjects were stratified by a gross stage of cancer and degree of operative curability . They were then r and omly assigned to either chemotherapy group or chemotherapy plus immunotherapy group . Immunotherapy used was intradermal injection of 400 micrograms of N-CWS which was given weekly for the first month and monthly thereafter . After the specimen was examined microscopically , the patients were classified by histological stage of cancer and radicality of surgical intervention into curative or non-curative groups . The patients were surveyed for survival period in December 1981 . No statistical difference was found between the two treatment groups in age , sex or operative procedures that might influence the patient 's survival . As a result , statistical intergroup difference in survival rates was not seen in patients of the curative group , probably due to short observation period . However , the intergroup difference in survival rates was statistically significant in patients of the non-curative group ( p less than 0.01 ) . These results indicate that the immunotherapy with BCG-CWS or with N-CWS is effective in patients undergoing gastrectomy for gastric cancer
Furthermore , this therapy could increase the dem and on radiation re sources .
There is no evidence on which to make a recommendation for patients with node-negative tumours that have not penetrated the muscularis propria .
For patients unable to undergo radiation , adjuvant chemotherapy alone may be of benefit , particularly for those with lymph-node metastases .
There is insufficient evidence from r and omized trials to recommend neoadjuvant chemotherapy , or neoadjuvant or adjuvant radiotherapy or immunotherapy , either alone or in combination , outside a clinical trial .
OBJECTIVE To make recommendations on the use of neoadjuvant or adjuvant therapy in addition to surgery in patients with resectable gastric cancer ( T1 - 4 , N1 - 2 , M0 ) .
OPTIONS Neoadjuvant or adjuvant treatments compared with " curative " surgery alone .
OUTCOMES Overall survival , disease-free survival , and adverse effects .
The radiation fields used can possibly damage the left kidney , result ing in hypertension and other renal problems .