Cognitive behavioral therapy may reduce relapse risk for adults with AN after weight restoration , although its efficacy in the underweight state remains unknown .
Variants of family therapy are efficacious in adolescents , but not in adults .
Evidence for AN treatment is weak ; evidence for treatment-related harms and factors associated with efficacy of treatment are weak ; and evidence for differential outcome by sociodemographic factors is nonexistent .
OBJECTIVE The RTI International-University of North Carolina at Chapel Hill Evidence -based Practice Center ( RTI-UNC EPC ) systematic ally review ed evidence on efficacy of treatment for anorexia nervosa ( AN ) , harms associated with treatments , factors associated with treatment efficacy , and differential outcome by sociodemographic characteristics .
A controlled trial of cisapride in anorexia nervosa.
To determine the efficacy of cisapride , 10 mg three times daily , in improving gastric emptying , reducing distress during meals , and facilitating weight gain in anorexia nervosa , we conducted an 8-week , r and omized , double-blind ,  placebo-controlled trial on 29 in patients . Measures included scintigraphic gastric emptying studies at 0 , 2 , 4 , and 8 weeks ; subjective distress during meals measured by visual analogue scales ; self-rating of degree of global improvement in symptoms associated with eating at end of study ; and weight measured weekly . Gastric emptying improved significantly but equally in both groups over the study period . Yet subjective measures were better in the cisapride group ; they rated themselves as more hungry ( p = .02 ) and more improved on the global measure of change in symptoms ( p = .02 ) . Even so , the  cisapride group did not gain more weight . The correlation between gastric emptying and weight gain was modest ( r = .30 ; p = .11 ) , and between gastric emptying and the subjective measures , virtually absent
Cognitive behavioral therapy may reduce relapse risk for adults with AN after weight restoration , although its efficacy in the underweight state remains unknown .
Variants of family therapy are efficacious in adolescents , but not in adults .
Evidence for AN treatment is weak ; evidence for treatment-related harms and factors associated with efficacy of treatment are weak ; and evidence for differential outcome by sociodemographic factors is nonexistent .
OBJECTIVE The RTI International-University of North Carolina at Chapel Hill Evidence -based Practice Center ( RTI-UNC EPC ) systematic ally review ed evidence on efficacy of treatment for anorexia nervosa ( AN ) , harms associated with treatments , factors associated with treatment efficacy , and differential outcome by sociodemographic characteristics .