The two articles that evaluated individuals with dyslipidemia showed improvement in lipid profile .
The mechanisms of action are still being studied .
ABSTRACT In this systematic review , we discuss the scientific evidence about the effect of dietary intake of seeds and sesame derivatives on lipid profile and blood pressure ( BP ) of hypertensive and dyslipidemic individuals .
Antihypertensive effects of sesamin in humans.
Sesamin , one of the lignans contained in sesame , has been considered to have medicinal effects . It has been reported that sesamin suppressed the development of hypertension in rats . In this study , using a double-blind , cross-over , placebo-controlled trial , we investigated the effect of 4-wk administration of sesamin on blood pressure ( BP ) in mildly hypertensive humans . Twenty-five middle-aged subjects with mild hypertension were divided into two groups , matched by age and body mass index . Twelve subjects were allocated to 4-wk intake of capsules with 60 mg sesamin per day and 13 subjects to 4-wk intake of a placebo ( period 1 ) . After a 4-wk washout period , the subjects received the alternative administration for 4 wk ( period 2 ) . BP decreased with statistical significance with the administration of sesamin ( systolic : 137.6+/-2.2 to 134.1+/-1.7 mmHg , p=0.044 , diastolic : 87.7+/-1.3 to 85.8+/-1.0 mmHg , p=0.045 ) , but little changed with the placebo ( systolic : 135.0+/-1.8 to 135.1+/-1.7 mmHg , diastolic : 85.9+/-1.2 to 86.6+/-1.2 mmHg ) . In conclusion , 4-wk administration of 60 mg sesamin significantly decreased BP by an average of 3.5 mmHg systolic BP and 1.9 mmHg diastolic BP . These results suggest that sesamin has an antihypertensive effect in humans . Epidemiological studies suggested that a 2 - 3 mmHg decrease in BP reduces the rate of cardiovascular diseases ; therefore , it is considered that BP reduction achieved by sesamin may be meaningful to prevent cardiovascular diseases
The two articles that evaluated individuals with dyslipidemia showed improvement in lipid profile .
The mechanisms of action are still being studied .
ABSTRACT In this systematic review , we discuss the scientific evidence about the effect of dietary intake of seeds and sesame derivatives on lipid profile and blood pressure ( BP ) of hypertensive and dyslipidemic individuals .