Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .
Roux-en-Y Bypass Gastroplasty: Markers of Oxidative Stress 6 Months After Surgery
Background This study examined the effect of weight loss on energy intake ,  vitamin C , E , β-carotene ( diet/blood ) , reduced glutathione ( GSH ) , C-reactive protein ( CRP ) , thiobarbituric acid reactive substances ( TBARS ) , catalase , and myeloperoxidase , in patients with Roux-en-Y bypass gastroplasty .  Methods Prospect i ve clinical study with control ( C ) and  bariatric ( B ) groups ( n = 20 each ) . Age was 38.8 ± 11.1 ( C ) and 37.8 ± 11.2 years ( B ) , and body mass indices ( BMI ) were 22.4 ± 2.4 and 48.1 ± 8.7 kg/m2 , respectively . Group C was assessed on a single occasion and B at three time points ( basal period and 3 and 6 months after gastroplasty ) . Results BMI was decreased at three ( 38.3 ± 1.7 , P = 0.018 ) and 6 months after surgery ( 34.9 ± 1.7 , P < 0.001 ) . Mean weight loss was 20.53 ± 1.1 after three and 27.96 ± 1.3 kg after 6 months . Serum vitamin C and β-carotene ( P < 0.01 and P < 0.001 , respectively ) were increased at 6 months compared to basal . Basal serum vitamin C ( P = 0.001 ) and β-carotene ( P < 0.001 ) were lower compared to controls . Serum vitamin E corrected for cholesterol and triglycerides was higher in group B at three ( P = 0.01 ) and 6 months ( P = 0.001 ) and lower at basal ( P < 0.001 ) compared to controls . GSH was higher in controls ( P < 0.001 ) compared to basal . Catalase ( P = 0.01 ) and TBARS ( P < 0.001 ) were higher in group B at 6 months . TBARS were higher ( P < 0.001 ) at basal compared to controls . Myeloperoxidase and CRP decreased in group B after three ( P = 0.028 , P = 0.010 ) and 6 months ( P < 0.001 , P = 0.001 ) , respectively . Conclusions Roux-en-Y bypass gastroplasty led to decreased proinflammatory parameters together with increased nutritional antioxidants , catalase , and TBARS , and decreased GSH 6 months after surgery
Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .