Intensive glycaemic control does not seem to reduce all cause mortality in patients with type 2 diabetes .
OBJECTIVE To assess the effect of targeting intensive glycaemic control versus conventional glycaemic control on  all cause mortality and cardiovascular mortality , non-fatal myocardial infa rct ion , microvascular complications , and severe hypoglycaemia in patients with type 2 diabetes .
[Long-term intensive glycemic and lipid control ameliorates the carotid intima medial thickness in type 2 diabetes mellitus].
OBJECTIVE To investigate whether long-term intensive glycemic and lipid control would ameliorate the carotid intima medial thickness ( IMT ) in patients with type 2 diabetes mellitus ( T2DM ) . METHODS IMT was evaluated on B-mode ultrasonography in 116 patients with T2DM .  Body mass index ( BMI ) , waist-to-hip ratio ( WHR ) , fasting blood glucose ( FBG ) , 2 hour postpr and ial glucose ( 2hPG ) , hemoglobin A(1)c(HbA(1)c ) , total cholesterol(TC ) , triglycerides ( TG ) , low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol ( HDL-C ) were also measured . Of all the patients 89 were divided r and omly into group of intensive glycemic and lipid control and group of conventional treatment and underwent 1 year clinical interview . RESULTS ( 1 ) IMT in patients with T2DM was significantly correlated with age(r = 0.515,P = 0.000 ) , SBP ( r = 0.208 , P = 0.025 ) , TC(r = 0.213,P = 0.022 ) , LDL-C(r = 0.253 , P = 0.006 ) and no correlations were found between IMT and BMI , WHR , FBG , 2hPG , HbA(1)c , TG and HDL-C. In multivariate regression analysis , age ( Beta = 0.527 , P = 0.000 ) and TC(Beta = 0.243 , P = 0.002 ) were significant independent determinants for IMT . ( 3 ) After 1 year the change of IMT in the group of intensive glycemic and lipid control was significantly different compared with the group of conventional treatment [ (-0.044+/-0.148)mm vs ( 0.056+/-0.178 ) , P<0.05 ] . The change of IMT was not significantly associated with the use of Metformin , Sulphonylurea and Aspirin , but significantly associated with the use of  statins  . The change of IMT in the group using statins was significantly different compared with that in the group without using statins[(-0.053+/-0.153)mm vs (0.042+/-0.165)mm , P < 0.05 ] . CONCLUSION Carotid IMT appears to be closely related to age and TC in the patients with T2DM . long-term intensive glycemic control and lipid control could ameliorate the IMT in patients with T2DM . The improvement of IMT may be associated with the use of statin drug
Intensive glycaemic control does not seem to reduce all cause mortality in patients with type 2 diabetes .
OBJECTIVE To assess the effect of targeting intensive glycaemic control versus conventional glycaemic control on  all cause mortality and cardiovascular mortality , non-fatal myocardial infa rct ion , microvascular complications , and severe hypoglycaemia in patients with type 2 diabetes .