Although , the meta- analysis conducted included a few number of studies , but has shown promising results on the effectiveness of N. sativa on glucose homeostasis and serum lipids .
BACKGROUND & OBJECTIVE ( S ) Global prevalence of type 2 diabetes ( T2D ) is very high and is currently growing alarmingly .
With respect to recent research ers ' attention to the potential role of herbal medicine in disease prevention and management , the present meta- analysis review investigates the effectiveness of Nigella sativa ( N. sativa ) , a popular herb , in T2D .
Effects of Dapagliflozin, an SGLT2 Inhibitor, on HbA1c, Body Weight, and Hypoglycemia Risk in Patients With Type 2 Diabetes Inadequately Controlled on Pioglitazone Monotherapy
OBJECTIVE To examine the safety and efficacy of dapagliflozin , a sodium-glucose cotransporter-2 inhibitor , added on to pioglitazone in type 2 diabetes inadequately controlled on pioglitazone . RESEARCH DESIGN AND METHODS Treatment-naive patients or those receiving metformin , sulfonylurea , or thiazolidinedione  entered a 10-week pioglitazone dose-optimization period with only pioglitazone . They were then r and omized , along with patients previously receiving pioglitazone ≥30 mg , to 48 weeks of double-blind dapagliflozin 5 ( n = 141 ) or 10 mg ( n = 140 ) or placebo  ( n = 139 ) every day plus open-label pioglitazone . The primary objective compared HbA1c change from baseline with dapagliflozin plus pioglitazone versus placebo plus pioglitazone at week 24 . Primary analysis was based on ANCOVA model using last observation carried forward ; all remaining analyses used repeated- measures analysis . RESULTS At week 24 , the mean reduction from baseline in HbA1c was −0.42 % for placebo versus −0.82 and −0.97 % for dapagliflozin 5 and 10 mg groups , respectively ( P = 0.0007 and P < 0.0001 versus placebo ) . Patients receiving pioglitazone alone  had greater weight gain ( 3 kg ) than those receiving dapagliflozin plus pioglitazone ( 0.7–1.4 kg ) at week 48 . Through 48 weeks : hypoglycemia was rare ; more events suggestive of genital infection were reported with dapagliflozin ( 8.6–9.2 % ) than placebo ( 2.9 % ) ; events suggestive of urinary tract infection showed no clear drug effect ( 5.0–8.5 % for dapagliflozin and 7.9 % for placebo ) ; dapagliflozin plus pioglitazone groups had less edema ( 2.1–4.3 % ) compared with placebo plus pioglitazone ( 6.5 % ) ; and congestive heart failure and fractures were rare . CONCLUSIONS In patients with type 2 diabetes inadequately controlled on pioglitazone  , the addition of dapagliflozin further reduced HbA1c levels and mitigated the pioglitazone-related weight gain without increasing hypoglycemia risk
Although , the meta- analysis conducted included a few number of studies , but has shown promising results on the effectiveness of N. sativa on glucose homeostasis and serum lipids .
BACKGROUND & OBJECTIVE ( S ) Global prevalence of type 2 diabetes ( T2D ) is very high and is currently growing alarmingly .
With respect to recent research ers ' attention to the potential role of herbal medicine in disease prevention and management , the present meta- analysis review investigates the effectiveness of Nigella sativa ( N. sativa ) , a popular herb , in T2D .