In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
Intake of artificially sweetened soft drinks and risk of preterm delivery: a prospective cohort study in 59,334 Danish pregnant women.
BACKGROUND Sugar-sweetened soft drinks have been linked to a number of adverse health outcomes such as high weight gain . Therefore , artificially sweetened soft drinks are often promoted as an alternative . However , the safety of artificial sweeteners has been disputed , and consequences of high intakes of artificial sweeteners for pregnant women have been minimally addressed . OBJECTIVE We examined the association between intakes of sugar-sweetened and artificially sweetened soft drinks and preterm delivery . DESIGN We conducted prospect i ve cohort analyses of 59,334 women from the Danish National Birth Cohort ( 1996 - 2002 ) . Soft drink intake was assessed in midpregnancy by using a food-frequency question naire . Preterm delivery ( lt 37 wk ) was the primary outcome measure . Covariate information was assessed by telephone interviews . RESULTS There was an association between intake of artificially sweetened carbonated and noncarbonated soft drinks and an increased risk of preterm delivery ( P for trend : le 0.001 , both variables ) . In comparison with women with no intake of artificially sweetened carbonated soft drinks , the adjusted odds ratio for women who consumed ge 1 serving of artificially sweetened carbonated soft drinks/d was 1.38 ( 95 % CI : 1.15 , 1.65 ) . The corresponding odds ratio for women who consumed ge 4 servings of artificially sweetened carbonated soft drinks/d was 1.78 ( 95 % CI : 1.19 , 2.66 ) . The association was observed for normal-weight and overweight women . A stronger increase in risk was observed for early preterm and moderately preterm delivery than with late-preterm delivery . No association was observed for sugar-sweetened carbonated soft drinks ( P for trend : 0.29 ) or for sugar-sweetened noncarbonated soft drinks ( P for trend : 0.93 ) . CONCLUSIONS Daily intake of artificially sweetened soft drinks may increase the risk of preterm delivery . Further studies are needed to reject or confirm these findings
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .