Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .
NaHCO(3) and KHCO(3) ingestion rapidly increases renal electrolyte excretion in humans.
This paper describes and quantifies acute responses of the kidneys in correcting plasma volume , acid-base , and ion disturbances result ing from  NaHCO(3 ) and KHCO(3 )  ingestion . Renal excretion of ions and water was studied in five men after ingestion of 3.57 mmol/kg body mass of sodium bicarbonate ( NaHCO(3 ) ) and , in a separate trial , potassium bicarbonate ( KHCO(3 ) ) .  Subjects had a Foley catheter inserted into the bladder and indwelling catheters placed into an antecubital vein and a brachial artery . Blood and urine were sample d in the 30-min period before , the 60-min period during , and the 210-min period after ingestion of the solutions . NaHCO(3 ) ingestion result ed in a rapid , transient diuresis and natriuresis . Cumulative urine output was 44 + /- 11 % of ingested volume , result ing in a 555 + /- 119 ml increase in total body water at the end of the experiment . The cumulative increase ( above basal levels ) in renal Na(+ ) excretion accounted for 24 + /- 2 % of ingested Na(+ ) . In the KHCO(3 ) trial , arterial plasma K(+ ) concentration rapidly increased from 4.25 + /- 0.10 to a peak of 7.17 + /- 0.13 meq/l 140 min after the beginning of ingestion . This increase result ed in a pronounced , transient diuresis , with cumulative urine output at 270 min similar to the volume ingested , natriuresis , and a pronounced kaliuresis that was maintained until the end of the experiment . Cumulative ( above basal ) renal K(+ ) excretion at 270 min accounted for 26 + /- 5 % of ingested K(+ ) . The kidneys were important in mediating rapid corrections of substantial portions of the fluid and electrolyte disturbances result ing from ingestion of KHCO(3 ) and NaHCO(3 ) solutions
Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .