In this third up date of the Cochrane review , there were no differences in effects of homocysteine-lowering interventions in the form of supplements of vitamins B6 , B9 or B12 given alone or in combination comparing with placebo on myocardial infa rct ion , death from any cause or adverse events .
BACKGROUND Cardiovascular disease , which includes coronary artery disease , stroke and peripheral vascular disease , is a leading cause of death worldwide .
Homocysteine is an amino acid with biological functions in methionine metabolism .
A postulated risk factor for cardiovascular disease is an elevated circulating total homocysteine level .
The impact of homocysteine-lowering interventions , given to patients in the form of vitamins B6 , B9 or B12 supplements , on cardiovascular events has been investigated .
This is an up date of a review previously published in 2009 , 2013 , and 2015 .
OBJECTIVES To determine whether homocysteine-lowering interventions , provided to patients with and without pre-existing cardiovascular disease are effective in preventing cardiovascular events , as well as reducing all-cause mortality , and to evaluate their safety .
Effect of vitamin B-12 and n-3 polyunsaturated fatty acids on plasma homocysteine, ferritin, C-reaction protein, and other cardiovascular risk factors: a randomized controlled trial.
OBJECTIVES Vitamin B-12 and n-3 polyunsaturated fatty acids ( PUFA ) decrease blood homocysteine ( Hcy ) concentrations . However , the combined effect of these nutrients on Hcy and ferritin , and C-reactive protein is limited and inconclusive . The objective was to examine the synergistic effect of vitamin B-12 in combination of n-3 PUFA on plasma Hcy , ferritin , and other biochemical markers . METHODS In a r and omized controlled trial , thirty eligible subjects were r and omly divided into three groups , and assigned to receive 1000 μg of vitamin B-12 , 2 g fish oil , or 1000 μg vitamin B-12 and 2 g fish oil , respectively , for 8 weeks . Plasma phospholipids ( PL ) fatty acids and biochemical markers were determined . This study was registered under Clinical Trials.gov Identifier : NCT01762072 . RESULTS Plasma PL 20:5n-3 , 22:6n-3 and n-3 PUFA was increased after 4 and 8 week supplementation of fish oil , and vitamin B-12+fish oil . Plasma concentrations of triacylglycerol , uric acid , C-reactive protein , and ferritin were significantly decreased after 4 and 8 week supplementation of fish oil , and vitamin B-12+fish oil . In all groups , significant changes in plasma Hcy were observed during the study period . Vitamin B-12 , fish oil , and vitamin B-12+fish oil supplementation lowered plasma Hcy concentrations by 22 % , 19 % , and 39 % , respectively . CONCLUSIONS The combination of vitamin B-12 and fish oil has a synergistic effect on lowering plasma concentrations of Hcy
In this third up date of the Cochrane review , there were no differences in effects of homocysteine-lowering interventions in the form of supplements of vitamins B6 , B9 or B12 given alone or in combination comparing with placebo on myocardial infa rct ion , death from any cause or adverse events .
BACKGROUND Cardiovascular disease , which includes coronary artery disease , stroke and peripheral vascular disease , is a leading cause of death worldwide .
Homocysteine is an amino acid with biological functions in methionine metabolism .
A postulated risk factor for cardiovascular disease is an elevated circulating total homocysteine level .
The impact of homocysteine-lowering interventions , given to patients in the form of vitamins B6 , B9 or B12 supplements , on cardiovascular events has been investigated .
This is an up date of a review previously published in 2009 , 2013 , and 2015 .
OBJECTIVES To determine whether homocysteine-lowering interventions , provided to patients with and without pre-existing cardiovascular disease are effective in preventing cardiovascular events , as well as reducing all-cause mortality , and to evaluate their safety .