RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .
Effects of telmisartan 80 mg and valsartan 160 mg on ambulatory blood pressure in patients with essential hypertension
Objectives This trial investigated and compared the antihypertensive efficacy of telmisartan and valsartan , two angiotensin II receptor blockers , used in monotherapy at their maximum recommended dose in hypertensive patients . Methods We studied 70 subjects ( 32 men and 38 women ) aged 47.6 ± 12.2 ( mean ± SD ) years , with mild to moderate essential hypertension ; they were r and omly assigned to receive monotherapy with either telmisartan ( 80 mg ) or valsartan ( 160 mg ) , in the form of a single daily tablet upon awakening . Blood pressure was measured by ambulatory monitoring every 20 min during the day and every 30 min at night for 48 consecutive hours before and after 3 months of treatment . Physical activity was simultaneously monitored every minute by wrist actigraphy to calculate accurately the diurnal and nocturnal means of blood pressure on a per subject basis . Results There was a highly significant blood pressure reduction during the 24 h with both drugs . The blood pressure reduction in the 24-h mean was significantly larger for valsartan 160 mg ( 18.6 and 12.1 mmHg for systolic and diastolic blood pressure , respectively ) than for telmisartan 80 mg ( 10.8 and 8.4 mmHg ; P < 0.001 between treatment-groups ) . There was also a highly significant reduction ( P < 0.001 ) of 6.5 mmHg in the 24-h mean of pulse pressure  after valsartan administration only . The trough : peak ratio and the smoothness index were slightly higher in systolic , but similar in diastolic blood pressure , for telmisartan as compared to valsartan . Conclusions Despite a shorter half-life , 160 mg/day valsartan was more effective in lowering blood pressure over 24 h than 80 mg/day telmisartan . Furthermore , valsartan was also more effective in lowering arterial pulse pressure , an observation that may have important therapeutic implication s , given the mounting evidence that pulse pressure may be a risk factor for future cardiovascular events
RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .