The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation .
Conclusion : This meta- analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels
ABSTRACT Objective : The aim of this systematic review and meta- analysis was to determine and clarify the impact of curcuminoids on  serum lipid levels .
Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial
Background . Obesity is a disorder often accompanied by a heightened state of systemic inflammation and immunoactivation . The present r and omized crossover trial aim ed to investigate the efficacy of curcumin , a bioactive polyphenol with established anti-inflammatory and immunomodulatory effects , on the serum levels of a panel of cytokines and mediators in obese individuals . Methods . Thirty obese individuals were r and omized to receive curcumin at a daily dose of 1 g or a matched placebo for 4 weeks . Following a 2-week wash-out period , each group was assigned to the alternate treatment regimen for another 4 weeks . Serum sample s were collected at the start and end of each study period . Serum levels of IL-1α , IL-1β , IL-2 , IL-4 , IL-6 , IL-8 , IL-10 , VEGF , IFNγ , EGF , MCP-1 , and TNFα were measured using a multiplex Biochip Array Technology based method . Results . Mean serum IL-1β ( P = 0.042 ) , IL-4 ( P = 0.008 ) , and VEGF ( P = 0.01 ) were found to be significantly reduced by curcumin therapy . In contrast , no significant difference was observed in the concentrations of IL-2 , IL-6 , IL-8 , IL-10 , IFNγ , EGF , and MCP-1 . Conclusions . The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1β , IL-4 , and VEGF
The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation .
Conclusion : This meta- analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels
ABSTRACT Objective : The aim of this systematic review and meta- analysis was to determine and clarify the impact of curcuminoids on  serum lipid levels .