We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
Sensitive period in flavor learning: effects of duration of exposure to formula flavors on food likes during infancy.
BACKGROUND & AIMS Emerging research has revealed the existence of periods in which the developing brain has heightened sensitivity to environmental influences . We discovered a sensitive period , < 4 months of age , when exposure to the flavor of extensively hydrolyzed protein hydrolysate formulas ( ePHF ) determines its hedonic tone . This formula has pronounced bitter , sour , and savory tastes compared to cow-milk-based formulas ( CMF ) . This study aim ed to determine the effects of duration of exposure during the sensitive period on a food containing an exemplar of the savory flavor . METHODS Formula-fed infants were r and omized into four groups at age 0.5 months : one control group fed the CMF for 8 months , and three groups fed ePHF for 1 , 3 , or 8 months and CMF otherwise . When infants were 8.5 months , their acceptance of a savory and plain broth was measured . RESULTS Infants fed hydrolysate formula for 3 or 8 months , but not 1 month , showed greater acceptance of the savory broth relative to the plain broth ( p < 0.01 ) and consumed it at a faster rate ( p = 0.01 ) . CONCLUSIONS The duration of flavor exposure affects infants ' earliest responses to foods : a 3-month exposure to ePHF shifted the hedonic tone for savory flavor
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .