Other benefits included fewer episodes of feed intolerance , better weight gain and growth velocity , decreased transition time from orogastric to breast feeds , and increased postpr and ial mesenteric flow .
There were no adverse effects of probiotic supplementation .
Probiotics reduced the time to full enteral feeds  in preterm neonates .
INTRODUCTION The optimization of enteral nutrition is a priority in preterm neonates worldwide .
Probiotics are known to improve gut maturity and function in preterm neonates .
To our knowledge , previous systematic review s have not adequately assessed the effects of probiotic supplementation on enteral nutrition in preterm neonates .
OBJECTIVE We assessed the evidence on effects of probiotics on enteral nutrition in preterm neonates .
Prophylactic Saccharomyces boulardii versus nystatin for the prevention of fungal colonization and invasive fungal infection in premature infants
Aim This study aims to compare the efficacy of orally administered Saccharomyces boulardii versus nystatin in prevention of fungal colonization and invasive fungal infections in very low birth weight infants . Method A prospect i ve , r and omized comparative study was conducted in preterm infants with a gestational age of ≤32 weeks and birth weight of ≤1,500 g. They were r and omized into two groups , to receive S. boulardii or nystatin .  Skin and stool cultures were performed for colonization and blood cultures for invasive infections , weekly . Results A total of 181 infants were enrolled ( S. boulardii group , n = 91 ; nystatin group , n = 90 ) . Fungal colonization of the skin ( 15.4 vs 18.9 % , p = 0.532 ) and the stool ( 32.2 vs 27 % , p = 0.441 ) were not different between the probiotic and nystatin groups . Two patients  had C and ida-positive blood culture in the nystatin group whereas none in the probiotic group . Feeding intolerance , clinical sepsis , and number of sepsis attacks were significantly lower in the probiotics group than in the nystatin group . Conclusion Prophylactic S. boulardii supplementation is as effective  as nystatin  in reducing fungal colonization and invasive fungal infection , more effective in reducing the incidence of clinical sepsis and number of sepsis attacks and has favorable effect on feeding intolerance
Other benefits included fewer episodes of feed intolerance , better weight gain and growth velocity , decreased transition time from orogastric to breast feeds , and increased postpr and ial mesenteric flow .
There were no adverse effects of probiotic supplementation .
Probiotics reduced the time to full enteral feeds  in preterm neonates .
INTRODUCTION The optimization of enteral nutrition is a priority in preterm neonates worldwide .
Probiotics are known to improve gut maturity and function in preterm neonates .
To our knowledge , previous systematic review s have not adequately assessed the effects of probiotic supplementation on enteral nutrition in preterm neonates .
OBJECTIVE We assessed the evidence on effects of probiotics on enteral nutrition in preterm neonates .