We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .
The effect of bendrofluazide and frusemide on the ventilatory response to carbon dioxide and hypoxia in normal man.
1 . We have determined the ventilatory response to CO 2 at two levels of end-tidal O 2 tension in eight normal subjects before and after ( 1 ) 4 days of 0.242 mmol ( 80 mg ) oral frusemide daily and ( 2 ) 4 days of 0.024 mmol ( 10 mg ) bendrofluazide daily . 2 . Frusemide produced no significant alkalosis , change in end-tidal CO 2 tension or alteration in the CO 2 response line . However , we did demonstrate a linear relationship between the change in plasma total CO 2 content and the change in intercept of the CO 2 response line in hyperoxia after frusemide . 3 . Bendrofluazide produced a metabolic alkalosis with no significant change in end-tidal CO 2 tension . The CO 2 response line after the drug showed a decrease in slope in hyperoxia and a shift to the right of the intercept in hypoxia . There was no relationship between change in plasma total CO 2 content and change in the intercept of the CO 2 response line in hyperoxia . 4 . If these results obtained on normal subjects are applicable to patients with chronic bronchitis and emphysema , frusemide might be the diuretic of choice for use with controlled oxygen therapy in the management of acute exacerbations of this disease when it is complicated by ventilatory failure
We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .