AUTHORS ' CONCLUSIONS Feeding with a soy formula can not be recommended for prevention of allergy or food intolerance in infants at high risk of allergy or food intolerance .
BACKGROUND Allergies and food reactions in infants and children are common and may be associated with a variety of foods including adapted cow 's milk formula .
Soy based formulas have been used to treat infants with allergy or food intolerance .
However , it is unclear whether they can help prevent allergy and food intolerance in infants without clinical evidence of allergy or food intolerance .
OBJECTIVES To determine the effect of feeding adapted soy formula compared to human milk , cow 's milk formula or a hydrolysed protein formula on preventing allergy or food intolerance in infants without clinical evidence of allergy or food intolerance .
Immune Status of Infants Fed Soy-Based Formulas With or Without Added Nucleotides for 1 Year: Part 1: Vaccine Responses, and Morbidity
Background Immunologic development of soy-fed infants has not been extensively studied . Early studies of soy flour – based formulas showed decreased immunoglobulin production when soy protein intake was limited . However , there were no significant differences in rotavirus vaccine responses between breast-fed and soy protein isolate – based formula-fed infants .  Nucleotides added to milk-based formula benefit infant immune status , but reports of the immunologic effects of adding nucleotides to soy-based formula are not available . This study evaluated immune status and morbidity of infants fed soy protein isolate formulas with and without added nucleotides for 1 year . Methods Newborn , term infants enrolled in a masked 12-month feeding trial were assigned r and omly to groups fed soy formula with or without added nucleotides ( n = 94 , n = 92 ) . A nonr and omized human milk/formula cohort ( n = 81 ) was concurrently enrolled . Recommended immunizations were administered at 2 , 4 , and 6 months . Immune status was determined from antibody responses to Haemophilus influenzae type b , tetanus , diphtheria , and poliovirus vaccines at 6 , 7 , and 12 months . Parents and physicians reported morbidity data . Results All vaccine responses were within normal ranges . No response differences were observed between infants fed soy formula and those fed nucleotide-supplemented soy . However , antibody to H. influenzae type b at 7 and 12 months was higher in infants fed nucleotide-supplemented soy than in infants fed human milk/formula ( P = 0.007 , P = 0.008 , respectively ) . Human milk/formula-fed infants had higher poliovirus neutralizing antibody at 12 months than did soy-fed infants ( P = 0.016 ) . Morbidity analyses showed that only physician-reported diarrhea was different among groups ( groups fed human milk/formula had less diarrhea than did soy groups , P = 0.011 ) . Conclusions Term infants fed soy protein isolate – based formulas  have normal immune development as measured by antibody responses to childhood immunizations
AUTHORS ' CONCLUSIONS Feeding with a soy formula can not be recommended for prevention of allergy or food intolerance in infants at high risk of allergy or food intolerance .
BACKGROUND Allergies and food reactions in infants and children are common and may be associated with a variety of foods including adapted cow 's milk formula .
Soy based formulas have been used to treat infants with allergy or food intolerance .
However , it is unclear whether they can help prevent allergy and food intolerance in infants without clinical evidence of allergy or food intolerance .
OBJECTIVES To determine the effect of feeding adapted soy formula compared to human milk , cow 's milk formula or a hydrolysed protein formula on preventing allergy or food intolerance in infants without clinical evidence of allergy or food intolerance .