The pooled estimate from the studies suggested that the addition of testosterone to HT regimens improved sexual function scores for postmenopausal women .
A significant adverse effect was a decrease in high-density lipoprotein ( HDL ) cholesterol levels .
However , there is evidence that adding testosterone to HT has a beneficial effect on sexual function in postmenopausal women .
There was a reduction in HDL cholesterol associated with the addition of testosterone to the HT regimens .
It is , therefore , difficult to estimate the effect of testosterone on sexual function in association with any individual hormone treatment regimen
BACKGROUND : The value of adding testosterone to hormone therapy ( HT ) for the management of peri- and postmenopausal women is controversial and has not been systematic ally review ed .
OBJECTIVES : To determine the benefits and risks of testosterone therapy for peri- and postmenopausal women taking hormone therapy .
Vasodilator effects of estrogen are not diminished by androgen in postmenopausal women.
OBJECTIVE To compare the effects of estrogen with estrogen- and rogen treatment on vaginal blood flow velocity and fingertip postocclusive hyperemic blood flow response . DESIGN Prospect i ve , r and omized , parallel , double-blind study . SETTING Healthy human volunteers in an academic research environment . PATIENT(S ) Postmenopausal women receiving estrogen replacement therapy for at least 12 months and treated with placebo before this investigation . INTERVENTION(S ) Esterified estrogens or esterified estrogen + methyltestosterone were administered orally ; laser Doppler velocimetry was used to determine vaginal and fingertip blood flow responses at baseline and after 4 and 8 weeks of daily drug administration . MAIN OUTCOME MEASURE(S ) Fingertip postocclusive area under curve ( AUC ) ; vaginal blood flow velocities . RESULT ( S ) The AUC for postocclusive fingertip blood flow and vaginal blood flow increased to a greater extent in the estrogen- and rogen group , but changes were not statistically significant between groups . CONCLUSION ( S ) Estrogen- and rogen treatment does not diminish the vasodilator effects of estrogen treatment in postmenopausal women
The pooled estimate from the studies suggested that the addition of testosterone to HT regimens improved sexual function scores for postmenopausal women .
A significant adverse effect was a decrease in high-density lipoprotein ( HDL ) cholesterol levels .
However , there is evidence that adding testosterone to HT has a beneficial effect on sexual function in postmenopausal women .
There was a reduction in HDL cholesterol associated with the addition of testosterone to the HT regimens .
It is , therefore , difficult to estimate the effect of testosterone on sexual function in association with any individual hormone treatment regimen
BACKGROUND : The value of adding testosterone to hormone therapy ( HT ) for the management of peri- and postmenopausal women is controversial and has not been systematic ally review ed .
OBJECTIVES : To determine the benefits and risks of testosterone therapy for peri- and postmenopausal women taking hormone therapy .