Mixed results were found for zinc , folic acid , vitamin C , and tryptophan , with nonsignificant results for inositol .
No major adverse effects were noted in the studies ( aside from minor digestive disturbance ) .
A meta- analysis of adjunctive omega-3 versus placebo revealed a significant and moderate to strong effect in favor of omega-3 .
Conversely , a meta- analysis of folic acid revealed a nonsignificant difference from placebo .
Current evidence supports adjunctive use of SAMe , methylfolate , omega-3 , and vitamin D with antidepressants to reduce depressive symptoms
OBJECTIVE There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants .
The adjunctive use of st and ardized pharmaceutical- grade nutrients , known as nutraceuticals , has the potential to modulate several neurochemical pathways implicated in depression .
While many studies have been conducted in this area , to date no specialized systematic review ( or meta- analysis ) has been conducted .
“Add-On”-therapy with an individualized preparation consisting of free amino acids for patients with a major depression
The efficacy of a deficit oriented add-on therapy with free amino acids in depressive patients treated with the antidepressant Remeron ®  was evaluated . About 40 in- patients were investigated by a r and omised double-blind  placebo-controlled study during 4 weeks . Plasma levels of 20 amino acids and measures of depression , suicidal behaviour and aggression were surveyed on admission and after a 4 weeks ’ therapy with Remeron ® plus an individualized amino acid mixture or placebo . The preparation of the amino acid mixture was based on an aminogram and consisted of essential amino acids plus vitamins and trace elements as co-factors for the amino acid metabolism . Patients of the experimental group showed a significantly better improvement of depression and a higher responder rate than those of the placebo group . The results suggest that oral application of a deficit oriented amino acid mixture can improve the therapeutic outcome of an antidepressant . Furthermore , lacking side effects of the amino acids result ing also in a better patient compliance may improve the benefit/risk ratio
Mixed results were found for zinc , folic acid , vitamin C , and tryptophan , with nonsignificant results for inositol .
No major adverse effects were noted in the studies ( aside from minor digestive disturbance ) .
A meta- analysis of adjunctive omega-3 versus placebo revealed a significant and moderate to strong effect in favor of omega-3 .
Conversely , a meta- analysis of folic acid revealed a nonsignificant difference from placebo .
Current evidence supports adjunctive use of SAMe , methylfolate , omega-3 , and vitamin D with antidepressants to reduce depressive symptoms
OBJECTIVE There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants .
The adjunctive use of st and ardized pharmaceutical- grade nutrients , known as nutraceuticals , has the potential to modulate several neurochemical pathways implicated in depression .
While many studies have been conducted in this area , to date no specialized systematic review ( or meta- analysis ) has been conducted .