Conclusion Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes .
Due to some limitations in this study , further studies are needed to reach a definitive conclusion about the effect of n-3 PUFAs on the levels of leptin and adiponectin in T2DM
Abstract Aim N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines .
Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes , we conducted a systematic review and meta- analysis study of r and omized placebo-controlled clinical trials that examined the effects of n-3 PUFAs on serum levels of leptin and adiponectin in patients with type 2 diabetes .
Addition of n-3 fatty acids to a 4-hour lipid infusion does not affect insulin sensitivity, insulin secretion, or markers of oxidative stress in subjects with type 2 diabetes mellitus.
Fatty acids ( FA ) can impair glucose metabolism to a varying degree depending on time of exposure and also of type of FA . Here we tested for acute effects of marine n-3 FA on insulin sensitivity , insulin secretion , energy metabolism , and oxidative stress . This was a r and omized , double-blind , crossover study in 11 subjects with type 2 diabetes mellitus . A 4-hour lipid infusion ( Intralipid [ Fresenius Kabi , Halden , Norway ] , total of 384 mL ) was compared with a similar lipid infusion partly replaced by Omegaven ( Fresenius Kabi ) that contributed a median of 0.1 g fish oil per kilogram body weight , amounting to 0.04 g/kg of marine n-3 FA . Insulin sensitivity was assessed by isoglycemic hyperinsulinemic clamps ; insulin secretion ( measured after the clamps ) , by C-peptide glucagon tests ; and energy metabolism , by indirect calorimetry . Infusion of Omegaven increased the proportion of n-3 FA in plasma nonesterified fatty acids ( NEFA ) compared with Intralipid alone ( 20:5n-3 : median , 1.5 % [ interquartile range , 0.6 % ] vs -0.2 % [ 0.2 % ] , P = .001 ; 22:6n-3 : 0.8 % [ 0.4 % ] vs -0.7 % [ 0.2 % ] , P = .001 ) . However , glucose utilization was not affected ; neither was insulin secretion or total energy production ( P = .966 , .210 , and .423 , respectively , for the differences between the lipid clamps ) . Omegaven tended to lower oxidation of fat ( P = .062 ) compared with Intralipid only , correlating with the rise in individual n-3 NEFA ( r = 0.627 , P = .039 ) . The effects of clamping on phospholipid FA composition , leptin , adiponectin , or F(2)-isoprostane concentrations were not affected by Omegaven . Enrichment of NEFA with n-3 FA during a 4-hour infusion of Intralipid failed to affect insulin sensitivity , insulin secretion , or markers of oxidative stress in subjects with type 2 diabetes mellitus
Conclusion Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes .
Due to some limitations in this study , further studies are needed to reach a definitive conclusion about the effect of n-3 PUFAs on the levels of leptin and adiponectin in T2DM
Abstract Aim N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines .
Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes , we conducted a systematic review and meta- analysis study of r and omized placebo-controlled clinical trials that examined the effects of n-3 PUFAs on serum levels of leptin and adiponectin in patients with type 2 diabetes .