Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention .
The data are insufficient to recommend the use of statins before EC .
Finally , perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF
The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation ( AF ) , inflammation and oxidative stress , with emphasis on the potential of statins to decrease the incidence of different types of AF , including new-onset AF , after electrical cardioversion ( EC ) and after cardiac surgery .
Observational and clinical trials have studied the impact of statin therapy on new-onset , post-EC or postoperative AF .
Relationship between C-reactive protein concentrations during glucocorticoid therapy and recurrent atrial fibrillation.
BACKGROUND Little direct information is available on the effect of C-Reactive Protein ( CRP ) lowering on the reduction of  recurrent atrial fibrillation ( AF ) .  METHODS AND RESULTS We compared low-dose glucocorticoid therapy ( 16 mg methylprednisolone for 4 weeks tapered to 4 mg for 4 months ) and placebo in 104 patients who had experienced persistent AF with a median concentration of CRP 1.14 mg/dL ( min=0.01 , max=2.58 ) .  Methylprednisolone reduced recurrent AF ( primary end-point ) from 50 % in the placebo group to 9.6 % in the glucocorticoid group and permanent AF ( exp and ed end-point ) from 29 % in the placebo group to 2 % in the glucocorticoid group . Survival distributions for methylprednisolone were significantly different ( for both primary and exp and ed end-point , P < 0.001 ) . In multivariate Cox analysis , average CRP concentrations during follow-up were significant predictors of the primary end-point , with a relative risk 6.72 ( P = 0.006 ) and the exp and ed end-point , with a relative risk of 11.67 ( P = 0.0006 ) . CONCLUSIONS CRP concentration is a risk factor for recurrent and permanent AF .  Methylprednisolone successfully prevents recurrent and permanent AF
Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention .
The data are insufficient to recommend the use of statins before EC .
Finally , perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF
The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation ( AF ) , inflammation and oxidative stress , with emphasis on the potential of statins to decrease the incidence of different types of AF , including new-onset AF , after electrical cardioversion ( EC ) and after cardiac surgery .
Observational and clinical trials have studied the impact of statin therapy on new-onset , post-EC or postoperative AF .