There was consistent evidence from cross-sectional data of an unfavourable association between total sedentary time and insulin sensitivity .
There was also some evidence that total sedentary time was unfavourably associated with fasting insulin , insulin resistance and triglycerides .
Furthermore , there was some evidence from cross-sectional data of a favourable association between breaks in sedentary time and triglycerides .
CONCLUSION Total sedentary time was consistently shown to be associated with poorer insulin sensitivity , even after adjusting for time spent in physical activity .
OBJECTIVE We conducted a systematic review to investigate the cross-sectional and prospect i ve associations of accelerometer-measured total sedentary time and breaks in sedentary time with individual cardiometabolic biomarkers in adults ≥18years of age .
Impact of objectively measured sedentary behaviour on changes in insulin resistance and secretion over 3 years in the RISC study: interaction with weight gain.
AIMS The importance of reducing sedentary time is increasingly being recognized in the prevention of diabetes and cardiovascular disease . Despite this , the prospect i ve association between sedentary time and physical activity with insulin sensitivity and cardiometabolic risk factors has been little studied . METHODS In an analysis of data from the European RISC study , sedentary time and time spent in activity of moderate or vigorous intensity were assessed by accelerometry at baseline in 313 men and 414 women , aged 30 - 60 years , with insulin sensitivity as measured by euglycaemic-hyperinsulinaemic clamp . Three years later , cardiometabolic risk factors ( anthropometry , glucose , insulin , lipids ) were available for 549 participants . RESULTS In cross-sectional analyses using baseline data , after adjusting for age , gender , recruitment centre and time spent in activity of moderate or vigorous intensity , significant unfavourable associations were observed between higher sedentary time with body weight , HDL cholesterol , triglycerides , clamp-measured insulin sensitivity and insulin secretion ( all P(trend)<0.002 ) .  Sedentary time  remained significantly associated with insulin secretion after adjusting for insulin sensitivity ( P(trend)=0.02 ) . In longitudinal analyses , higher baseline sedentary time  was associated with 3-year increases in fasting glucose , fasting insulin and the HOMA insulin-resistance index score for the 50 % of the study population who increased their BMI by at least 0.3 kg/m(2 ) ( all P(trend)<0.01 ) ; these relationships remained significant after adjusting for time spent in activity of moderate or vigorous intensity . The 3-year increase in insulin secretion was lower in those spending more time doing activity of moderate or vigorous intensity ( P(trend)=0.03 ) . CONCLUSION These prospect i ve data suggest that less sedentary behaviour may partly counteract some of the negative effects of increasing body weight on glucose-insulin homoeostasis
There was consistent evidence from cross-sectional data of an unfavourable association between total sedentary time and insulin sensitivity .
There was also some evidence that total sedentary time was unfavourably associated with fasting insulin , insulin resistance and triglycerides .
Furthermore , there was some evidence from cross-sectional data of a favourable association between breaks in sedentary time and triglycerides .
CONCLUSION Total sedentary time was consistently shown to be associated with poorer insulin sensitivity , even after adjusting for time spent in physical activity .
OBJECTIVE We conducted a systematic review to investigate the cross-sectional and prospect i ve associations of accelerometer-measured total sedentary time and breaks in sedentary time with individual cardiometabolic biomarkers in adults ≥18years of age .