The only eligible r and omised clinical trial did not demonstrate any consistent effects of NIRS plus a guideline on the assessed clinical outcomes .
The trial was , however , only powered to detect difference in cerebral oxygenation , not morbidities or mortality .
BACKGROUND Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants .
Cerebral near-infrared spectroscopy ( NIRS ) enables continuous estimation of cerebral oxygenation .
This diagnostic method coupled with appropriate interventions if NIRS is out of normal range ( that is cerebral oxygenation within the 55 % to 85 % range ) may offer benefits without causing more harms .
Therefore , NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of r and omised clinical trials and quasi-r and omised studies .
OBJECTIVES To evaluate the benefits and harms of interventions that attempt to alter cerebral oxygenation guided by cerebral NIRS monitoring in order to prevent cerebral injury , improve neurological outcome , and increase survival in preterm infants born more than 8 weeks preterm .
Comparison between cerebral tissue oxygenation index measured by near-infrared spectroscopy and venous jugular bulb saturation in children
Objective To compare the cerebral tissue oxygenation index ( TOI ) measured by near-infrared spectroscopy ( NIRS ) with venous oxygen saturation in the jugular bulb ( SjO2 ) during elective cardiac catheterization in children . Design and setting Prospect i ve observational clinical study in a catheterization laboratory for pediatric cardiology . Patients Sixty children with congenital heart defects admitted to the catheterization laboratory . Measurements and results TOI measured noninvasively by NIRS was compared to SjO2 measured in the jugular bulb during cardiac catheterization . Patients were divided into two groups regarding body weight : below ( n=29 ) and above 10 kg ( n=31 ) . Linear regression analysis and Pearson ’s correlation coefficient were calculated . Bl and -Altman analysis , sensitivity , and specificity calculation for spatially resolved near-infrared spectroscopy with a cutoff level of 60 % were performed . Simultaneously measured values for SjO2 ( 67.3±9.8 % , 40–84.1 % ) and TOI ( 65.7±7.2 % , 39–80 % ) showed a significant correlation ; the correlation in children weighing under 10 kg was stronger in children weighing over 10 kg . Bl and -Altman analysis showed a mean bias of −1.8 % with limits of agreement between 11.7 % and −15.3 % for all children . Sensitivity and specificity of the SRS method were 46 % and 91 % , respectively , for all children and 53 % and 83 % respectively in infants weighing under 10 kg . Conclusions The results demonstrate that despite a significant correlation , sensitivity of spatially resolved spectroscopy is poor , and it is question able whether TOI can be used reliably to detect low SjO2
The only eligible r and omised clinical trial did not demonstrate any consistent effects of NIRS plus a guideline on the assessed clinical outcomes .
The trial was , however , only powered to detect difference in cerebral oxygenation , not morbidities or mortality .
BACKGROUND Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants .
Cerebral near-infrared spectroscopy ( NIRS ) enables continuous estimation of cerebral oxygenation .
This diagnostic method coupled with appropriate interventions if NIRS is out of normal range ( that is cerebral oxygenation within the 55 % to 85 % range ) may offer benefits without causing more harms .
Therefore , NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of r and omised clinical trials and quasi-r and omised studies .
OBJECTIVES To evaluate the benefits and harms of interventions that attempt to alter cerebral oxygenation guided by cerebral NIRS monitoring in order to prevent cerebral injury , improve neurological outcome , and increase survival in preterm infants born more than 8 weeks preterm .