Among the outcomes examined , the highest absolute risk increase was for heart failure .
Associations between atrial fibrillation and included outcomes were broadly consistent across subgroups and in sensitivity analyses .
Atrial fibrillation is associated with an increased risk of death and an increased risk of cardiovascular and renal disease .
OBJECTIVE To quantify the association between  atrial fibrillation and cardiovascular disease , renal disease , and death .
Mortality risk attributable to atrial fibrillation in middle-aged and elderly people in the Japanese general population: nineteen-year follow-up in NIPPON DATA80.
BACKGROUND The extent to which  atrial fibrillation ( AF ) contributes to mortality in the Japanese general population has not been clarified . METHODS AND RESULTS A r and omly sample d general population from all over Japan ( 4,154 men , 5,329 women ; age > or = 30 years ) was enrolled .  Single electrocardiogram recordings  were taken in the baseline survey . Stroke death , cardiovascular deaths and all-cause deaths during the subsequent 19 years were analyzed by the presence of AF at baseline . Cox 's regression analysis was carried out to estimate the hazard ratios ( HRs ) of each cause of death attributable to AF after adjusting for other risk factors . Prevalence of AF was 0.64 % in the study . The observed person-years were 162,980 among persons without AF and 699 among persons with AF . There were 1,919 deaths . Multivariate adjusted HRs for stroke death , cardiovascular death and all-cause death were 2.69 , 2.76 and 1.88 , respectively ( p<0.05 ) . These HRs were 14.7 , 9.63 and 4.00 among persons aged 64 years or younger ( p<0.05 ) . CONCLUSION AF affects stroke mortality , cardiovascular mortality and all-cause mortality in the Japanese general population . Careful attention should be paid to persons with AF in order to prevent future cardiovascular events
Among the outcomes examined , the highest absolute risk increase was for heart failure .
Associations between atrial fibrillation and included outcomes were broadly consistent across subgroups and in sensitivity analyses .
Atrial fibrillation is associated with an increased risk of death and an increased risk of cardiovascular and renal disease .
OBJECTIVE To quantify the association between  atrial fibrillation and cardiovascular disease , renal disease , and death .