RESULTS Following an extensive review of selected studies from the 201 articles , the studies indicate that each of the psychotropic medications review ed impact alpha , beta , delta and theta waves independently and differently from each other .
Additionally , certain medications , particularly haloperidol and valproic acid , have dissimilar results exemplified in all waveforms .
OBJECTIVES It is known that psychotropic medications have an impact on the readings found in Electroencephalogram ( EEG ) .
In the field of psychiatry , there are several psychotropics utilized by clinicians .
This review seeks to investigate all the available data for psychotropic drugs and their impact on EEG changes .
Lamotrigine decreases EEG synchronization in a use-dependent manner in patients with idiopathic generalized epilepsy
OBJECTIVE To investigate the quantitative EEG effects of lamotrigine ( LTG ) monotherapy . HYPOTHESIS LTG was predicted to decrease thalamo-cortical neuronal synchronization in idiopathic generalized epilepsy ( IGE ) . METHODS Waking EEG background activity of 19 IGE patients was investigated before treatment and in the course of LTG monotherapy .  Raw absolute power ( RAP ) , raw percent power ( RRP ) , and raw mean frequency ( RMF ) were computed for 19 electrodes and four frequency b and s ( delta=1.5 - 3.5Hz , theta=3.5 - 7.5Hz , alpha=7.5 - 12.5Hz , and beta=12.5 - 25.0Hz ) . Inter- and intrahemispheric coherence was computed for eight electrode pairs and the four frequency b and s. In addition , scalp-averages were calculated for each variable . Group differences were computed by means of nonparametric statistics including correction for multiple comparisons . RESULTS Main results were decreased delta and theta RAP ( p<0.05 for scalp-averages ) . LTG compressed the delta , theta , and alpha RAP data sets , reducing the upper limit of the scatter in particular . Spearman r-values indicated marked correlation between the starting values ( RAPuntreated ) and the LTG-related decrease ( RAPtreated-RAPuntreated ) in three b and s : delta ( r=-0.72 ; p=0.0005 ) , theta ( r=-0.59 ; p=0.007 ) , and alpha ( r=-0.61 ; p=0.006 ) . Thus , the greater the baseline neuronal synchronization , the marked the dampening effect of LTG on it . The remaining findings were decreased theta RRP , theta RMF , and increased alpha RMF ( p<0.05 for scalp-averages ) . The electrode-related changes were small but topographically consistent across the 19 electrode sites . LTG did not affect coherence . CONCLUSIONS 1 . LTG partially normalized the spectral composition of EEG background activity . LTG decreased pathological thalamo-cortical synchronization in use-dependent manner . 2 . LTG did not cause quantitative EEG alterations suggesting worsening of the physiological brain functions . Instead , its profile suggested a mild psychostimulant effect . SIGNIFICANCE The results contribute to the underst and ing of the effect of LTG at the network level
RESULTS Following an extensive review of selected studies from the 201 articles , the studies indicate that each of the psychotropic medications review ed impact alpha , beta , delta and theta waves independently and differently from each other .
Additionally , certain medications , particularly haloperidol and valproic acid , have dissimilar results exemplified in all waveforms .
OBJECTIVES It is known that psychotropic medications have an impact on the readings found in Electroencephalogram ( EEG ) .
In the field of psychiatry , there are several psychotropics utilized by clinicians .
This review seeks to investigate all the available data for psychotropic drugs and their impact on EEG changes .