The testosterone and control groups demonstrated no significant difference for other outcomes .
In conclusion , we found that TRT can improve glycemic control and decrease triglyceride levels of hypogonadal men with T2DM .
This systematic review was aim ed at assessing the metabolic effects of testosterone replacement therapy ( TRT ) on hypogonadal men with type 2 diabetes mellitus ( T2DM ) .
The effect of androgen deprivation therapy on fasting serum lipid and glucose parameters.
PURPOSE Although prostate cancer specific mortality is decreasing , there is little effect on overall mortality in this population , suggesting the possibility of an increased risk of death from nonprostate cancer related causes . And rogen deprivation therapy could adversely affect cardiovascular health . We investigated changes in lipid and glucose during and rogen deprivation therapy . MATERIAL S AND METHODS We performed an exploratory analysis of pooled data from 3 prospect i ve clinical trials aim ed at achieving medical castration by comparing the gonadotropin releasing hormone antagonist abarelix , the gonadotropin releasing hormone agonist leuprolide acetate and leuprolide acetate plus the anti and rogen bicalutamide . Most patients were treated in the neoadjuvant setting or because of biochemical recurrence . Fasting serum lipid , glucose and hemoglobin A1C were determined in 1,102 men at baseline , and on treatment days 85 and 169 . In the current study men were categorized into 3 treatment groups according to the type of and rogen deprivation therapy , that is leuprolide acetate , leuprolide acetate plus bicalutamide or abarelix , and statin therapy . RESULTS Significant increases in total cholesterol , triglyceride and high density lipoprotein-cholesterol were observed in patients on leuprolide acetate or abarelix  but not in patients on leuprolide acetate plus bicalutamide . Consistent changes in low density lipoprotein-cholesterol were not detected . Increased total cholesterol was usually due to an increase in high density lipoprotein-cholesterol . Hemoglobin A1C increased from baseline to day 85 only and there were no significant changes in fasting glucose measurements . The type of and rogen deprivation therapy did not affect these parameters . CONCLUSIONS Short-term and rogen deprivation therapy affects serum lipid and hemoglobin A1C independent of statin therapy
The testosterone and control groups demonstrated no significant difference for other outcomes .
In conclusion , we found that TRT can improve glycemic control and decrease triglyceride levels of hypogonadal men with T2DM .
This systematic review was aim ed at assessing the metabolic effects of testosterone replacement therapy ( TRT ) on hypogonadal men with type 2 diabetes mellitus ( T2DM ) .