For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .
Time/duration effectiveness of sildenafil versus tadalafil in the treatment of erectile dysfunction in male spinal cord-injured patients
Study design : A r and omized , blinded , crossover clinical trial comparing sildenafil versus tadalafil for erectile dysfunction ( ED ) in male spinal cord-injured ( SCI ) patients . Objectives : To compare the safety , time/ duration effectiveness , and the impact on the quality of life ( QoL ) of tadalafil 10 mg versus sildenafil 50 mg . Setting : Neurourology Section , Careggi Hospital , Florence , Italy . Methods : During a screening ( visit 1 ) , a diary card was distributed , in which the subjects assessed , after each attempt at intercourse the quality of their erection , responding ( Yes/No ) to both Sexual Encounter Profile Questions 2 ( SEP2 ) and 3 ( SEP3 ) . The subjects made at least four attempts at intercourse . At visit 2 , 15 patients ( group 1 ) were assigned sildenafil and 15 ( group 2 ) started with tadalafil . Responses to baseline International Index of Erectile Function 5 items ( IIEF-5 ) , Questions 13–14 ( IIEF 15 items ) and SEP diary were recorded . Patients attempted intercourse on four separate occasions : within 4 h of taking the first tablet , within 12 h for the second tablet , 24 h for the third , and the fourth from 24 to 36 h. At visit 3 , the investigators evaluated the effectiveness with the same measures used at baseline . After a wash-out period , at visit 4 , Group 1 was given tadalafil , and Group 2 was given sildenafil . Patients were required to observe the same criteria in taking the four tablets as in visit 2 . After 4 weeks ( visit 5 ) , we evaluated the patients as we did in visit 3 . Results : Overall , 28 patients completed the study . No subjects discontinued the drugs due to drawbacks . Tadalafil allowed a majority of men in this trial to achieve both normal sexual functioning up to 24 h postdosing compared to sildenafil ( P<0.01 ) and improved overall sex life satisfaction as well as sexual relations with partner . Conclusion : Based on these data , tadalafil may have the potential to become an important treatment option for ED in SCI patients .Sponsorship : This study was not sponsored
For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .