Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .
Therapeutic Effects of Nandrolone and Testosterone in Adult Male HIV Patients With AIDS Wasting Syndrome (AWS): A Randomized, Double-Blind, Placebo-Controlled Trial
Abstract Purpose : We aim ed to compare therapeutic effects of intramuscular ( IM ) n and rolone decanoate and IM testosterone enanthate in male HIV patients with AIDS wasting syndrome ( AWS ) with placebo control . Methods : In this r and omized , double-blind , placebo-controlled , 12-week trial , 104 patients with AWS who satisfied our inclusion criteria were r and omly allotted in a 2:2:1 ratio to the 3 intervention groups : n and rolone , testosterone , and placebo . We administered 150 mg n and rolone and 250 mg testosterone ( both IM , biweekly ) . The primary outcome measure was a comparison of absolute change in weight at 12 weeks between the n and rolone decanoate , testosterone , and placebo groups . Results : Intent-to-treat analysis was done . The n and rolone group recorded maximum mean increase in weight ( 3.20 kg ; post hoc P < .01 compared to placebo ) . Body mass index ( BMI ) of subjects in the n and rolone group had a significantly greater increase ( mean = 1.28 ) compared to both testosterone ( post hoc P < .05 ) and placebo ( post hoc P < .01 ) . Waist circumference and triceps skinfold thickness of patients on n and rolone showed similar results . N and rolone also ensured a better quality of life . Patients with low testosterone level ( <3 ng/mL ) benefited immensely from n and rolone therapy , which increased their weight and BMI significantly compared to placebo ( P < .05 ) . Conclusion : Our trial demonstrates the superior therapeutic effects of n and rolone in male AWS patients , including the and rogen deficient
Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .