Conclusions Whole flaxseed , but not flaxseed oil and lignan extract , has significant effects on improving glycemic control .
Context The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent .
Objective The present study aim ed to systematic ally review and analyze r and omized controlled trials assessing the effects of flaxseed consumption on glycemic control .
The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women.
BACKGROUND AND AIM Plant lignans are metabolised by the colonic micro-flora to the mammalian lignans enterodiol and enterolactone , which are hypothesized to be cardioprotective . The aim of this study was to investigate the effects of a plant lignan complex isolated from flaxseed , providing 500 mg/d of secoisolariciresinol diglucoside , on inflammatory markers . METHODS AND RESULTS Healthy postmenopausal women ( n=22 ) completed a r and omised double-blind , placebo-controlled crossover study . Women consumed daily a low-fat muffin , with or without a lignan complex , for 6 weeks , separated by a 6-week washout period . A significant difference of approximately 15 % ( P=0.028 ) was observed for C-reactive protein ( CRP ) concentration between the lignan complex intervention period and placebo period . CRP concentrations ( median ; 25th , 75th percentiles ) were 0.88 ( 0.63 , 2.05 ) mg/L at baseline and 0.92 ( 0.59 , 1.49 ) mg/L after the lignan complex intervention period compared with 0.80 ( 0.62 , 1.62 ) mg/L at baseline and 1.10 ( 0.72 , 1.62 ) mg/L after placebo . No significant differences in interleukin-6 , tumor necrosis factor-alpha , soluble intracellular adhesion molecule-1 , soluble vascular cell adhesion molecule-1 , and monocyte chemoattractant protein-1 were found between the lignan complex intervention period and placebo period . CONCLUSION Daily consumption for 6 week of a low-fat muffin enriched with a lignan complex may reduce CRP concentrations compared to a low-fat muffin with no lignans added
Conclusions Whole flaxseed , but not flaxseed oil and lignan extract , has significant effects on improving glycemic control .
Context The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent .
Objective The present study aim ed to systematic ally review and analyze r and omized controlled trials assessing the effects of flaxseed consumption on glycemic control .