Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .
Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study.
OBJECTIVE The aim of this study was to evaluate the effects of isoflavone on the climacteric symptoms ( Kupperman Menopausal index ) , vaginal pH , vaginal cytology ( vaginal maturation index ) and endometrium ( evaluated by ultrasound and biopsy ) in postmenopausal women . METHODS It was a single-center , 6-month , r and omized , double-blind , estrogen-controlled trial . Seventy-nine women were r and omly assigned to one of the two treatment groups : isoflavone ( n=40 ) : 300 mg of the st and ardized soy extract with a medium dose of 120 mg isoflavones/day as glycoside and aglycone ( 60 mg twice a day ) , or estrogen ( n=39 ) : one capsule of 0.625 mg conjugated equine estrogens and other capsule with glucose 0.625 mg ( placebo ) . RESULTS After treatment , there was a decrease in the symptomatology in both estrogen and isoflavone groups . There was a significant decrease in vaginal pH , an increase in superficial vaginal cells and endometrium proliferation after 3 and 6 months of treatment in the estrogen group , but no differences were observed in the isoflavone group for these variables . CONCLUSIONS We concluded that the daily st and ardized soy extract with 120 mg isoflavones ' effect on symptoms was similar to that from estrogen . Soy isoflavone has no effect on endometrium and vaginal mucosa during the treatment
Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .