Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .
Campylobacter pylori-associated gastritis: a double-blind placebo-controlled trial with amoxycillin.
We r and omly assigned 45 adult patients with Campylobacter pylori-confirmed antral gastritis to 8 days of treatment with 1 g amoxycillin suspension twice a day , or placebo , according to a double-blind study design . At the end of therapy , 91 % of patients treated with amoxycillin demonstrated clearance of the organism from the antrum , compared with 16 % in the placebo group ( p less than 0.001 ) . Active antral gastritis resolved in 68 % of patients in the amoxycillin group versus only 9 % in the placebo group ( p less than 0.001 ) . No significant difference was observed when looking at the evolution of chronic only gastritis . No significant improvement was observed in the assessment of clinical symptoms and endoscopic appearance . Reappearance of C. pylori and significant worsening of the histological score of active gastritis was observed after 2 wk in all patients . In a second study phase , 18 patients initially not cleared of their bacteria received amoxycillin single blind for 14 days . Clearance of bacteria associated with improvement or resolution of active gastritis was observed in 72 % of the cases . In this subgroup , all patients investigated after 1 month were recolonized with C. pylori and , again , had histological active gastritis . We conclude that amoxycillin is effective in treating active antral gastritis associated with C. pylori , but not in preventing relapses , which occur in all cases within 1 month after therapy
Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .