Currently available evidence weakly supports the inference that testosterone use in men is not associated with important cardiovascular effects .
OBJECTIVE To conduct a systematic review and meta- analysis of r and omized trials that assessed the effect of testosterone use on  cardiovascular events and risk factors in men with different degrees of and rogen deficiency .
Pharmacokinetic characteristics, efficacy, and safety of buccal testosterone in hypogonadal males: a pilot study.
Transbuccal administration of drugs provides an easy route of administration . To test the safety and efficacy of a novel testosterone ( T ) product , we performed a r and omized , double blind , placebo-controlled study in a parallel design . Men with serum T levels below 250 ng/dL were administered either an active buccal tablet containing 10 mg T ( n = 7 ) or a buccal placebo tablet ( n = 6 ) containing 3 mg pseudoephedrine HCl for taste matching . Men were studied while taking a st and ard T enanthate dose , after 6 weeks of a wash-out period , and after 8 weeks of therapy . The men were matched for age ( mean + /- SD , 41 + /- 16 vs. 47 + /- 16 ) and type of hypogonadism ( three primary testicular failures in each group , with the remainder having a central etiology ) . Acute pharmacokinetic testing showed peak serum hormone levels at 30 min , with a mean serum T concentration of 2688 + /- 147 ng/dL ( range , 1820 - 3770 ng/dL ) . Levels returned to baseline in 4 - 6 h , result ing in a total T area under the curve level of 3865 ng/hn.dL , less than that using other available forms of T administration . Similar pharmacokinetics were observed for the hormone 's metabolites , bioavailable T , free T , and estradiol . After 8 weeks of treatment , the results of nocturnal penile tumescence studies evaluating rigidity and circumference were significantly different from those in the placebo group ( P < 0.05 ) and comparable to those during T enanthate therapy . In conclusion , transbuccal T therapy was sufficient to maintain normal sexual function while minimizing the total time of exposure to elevated circulating serum T levels
Currently available evidence weakly supports the inference that testosterone use in men is not associated with important cardiovascular effects .
OBJECTIVE To conduct a systematic review and meta- analysis of r and omized trials that assessed the effect of testosterone use on  cardiovascular events and risk factors in men with different degrees of and rogen deficiency .