They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .
Prophylactic vitamin D in healthy infants: assessing the need.
The objective was to evaluate the need for vitamin D prophylaxis in healthy infants . This was a prospect i ve and r and omized study performed at primary care clinics . Eighty-eight full-term 1-month-old healthy infants were r and omly assigned to receive ( n = 41 ) or not ( n = 47 ) 402 IU/d of vitamin D for 1 year . Primary outcome measures were serum 25-hydroxyvitamin D ( 25OHD ) and parathyroid hormone ( PTH ) concentrations at 3 , 6 , and 12 months of age ; secondary measures included data on feeding , habitat , season of birth , sun exposure , and physical examination . At 3 and 6 months of age , serum 25OHD levels ( ±SD ) were significantly higher ( P < .001 ) in the prophylaxis group . In the group without prophylaxis , serum 25OHD increased with age ; and breast-fed infants aged 3 months had the lowest value ( 20.2 ± 9.4 ng/mL ) , which was significantly ( P = .001 ) lower than that of formula-fed infants ( 35.0 ± 9.7 ng/mL ) . The PTH levels were not influenced by the prophylaxis or feeding . No influence of either the habitat or season of birth on serum 25OHD concentrations was demonstrated . No infant had clinical signs of vitamin D deficiency . Serum 25OHD and PTH concentrations were weakly but significantly correlated ( r = -0.29 , P = .009 ) at 3 months of age . Healthy infants  without vitamin D prophylaxis had lower circulating concentrations of 25OHD at 3 and 6 months of age , the lowest value being found in 3-month breast-fed infants . The clinical relevance of these findings is probably negligible because serum 25OHD levels spontaneously increased with age and were not associated with high serum PTH . Clinical manifestations of rickets were not observed
They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .