In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .
Enamel matrix proteins and systemic antibiotics as adjuncts to non-surgical periodontal treatment: clinical effects.
OBJECTIVES The purpose of the present study was to evaluate the clinical effects of non-surgical periodontal treatment , supplemented with enamel matrix derivative ( EMD ) and /or systemic antibiotics , in deep periodontal pockets of patients with chronic periodontitis . METHODS This was a r and omized , placebo-controlled longitudinal clinical trial of 12 months duration . Using a split-mouth design , 16 subjects were r and omly assigned to scaling and root planing ( SRP ) with EMD or placebo in contra-lateral dentition areas . One half of the subjects received 250 mg metronidazole and 375 mg amoxicillin three times a day for 7 days and the other half received a placebo . One inter-proximal periodontal lesion was chosen as study site in each of the contra-lateral quadrants . RESULTS Subjects treated with systemic antibiotics yielded significantly better clinical results than those treated with placebo . In these cases , probing pocket depth was reduced significantly more after 6 months ( 3.0+/-2.1 mm versus 1.6+/-1.4 mm , p=0.05 ) , and the mean clinical attachment gain was significantly greater after 6 months ( 2.3+/-1.9 mm versus 0.7+/-1.6 mm , p=0.02 ) and 12 months ( 2.3+/-3.5 mm versus 0.4+/-3.8 mm , p=0.02 ) . Sites treated with the antibiotics plus EMD gained the largest amount of clinical attachment . There was no significant benefit of EMD adjunctive to SRP in subjects not treated with antibiotics . CONCLUSIONS The present study supports the notion that optimal repair and regeneration of the periodontium requires suppression of the microbiota causing periodontal disease
In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .