Based on the available evidence , motor evoked potentials at rest were the only biomarker that predicted motor outcome in individuals with severe arm impairment following stroke .
To build an underst and ing of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke , we conducted a pooled individual data systematic review to : 1 ) characterize brain biomarkers ; 2 ) determine relationship(s ) between biomarkers and motor outcome ; and 3 ) establish relationship(s ) between biomarkers and motor recovery .
The predictive value of cortical activation by passive movement for motor recovery in stroke patients.
PURPOSE Contralateral primary sensori-motor cortex ( SM1 ) activation by passive movement was investigated by functional MRI ( fMRI ) at the early stage of stroke , to determine whether SM1 activation can be used to predict the degree of motor recovery of the hemiplegic h and . METHODS We studied 17 stroke patients who showed complete paralysis of a hemiplegic h and at onset . The motor function of the hemiplegic h and was assessed on 4 separate occasions ( at onset , at fMRI evaluation ( performed < 4 weeks after onset ) , and 3 and 6 months after onset ) . Significant motor recovery was defined as recovery of the affected h and to the extent of it being able to prehend an object against gravity at least at 6 months after onset . RESULTS The patients having an activated contralateral SM1 showed better motor recovery than those who did not . Only a fourth of the patients with an activated contralateral SM1 experienced a significant motor recovery , whereas none of the patients with an inactivated SM1 showed an improvement 6 months after onset , however , the incidence of significant motor recovery was not significantly difference between the two groups . CONCLUSION It appears that contralateral SM1 activation by passive movement in the early stage of stroke has a low predictive value for the motor recovery of the hemiplegic h and , because the activation of the contralateral SM1 by passive movement appears to be mediated by somatosensory input to the cortex from the thalamus rather than from the motor pathway
Based on the available evidence , motor evoked potentials at rest were the only biomarker that predicted motor outcome in individuals with severe arm impairment following stroke .
To build an underst and ing of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke , we conducted a pooled individual data systematic review to : 1 ) characterize brain biomarkers ; 2 ) determine relationship(s ) between biomarkers and motor outcome ; and 3 ) establish relationship(s ) between biomarkers and motor recovery .