Lipid-lowering therapy is effective in reducing cardiovascular mortality and morbidity in people with PAD .
It may also improve local symptoms .
Until further evidence on the relative effectiveness of different lipid-lowering agents is available , use of a statin in people with PAD and a blood cholesterol level > /=3.5 mmol/litre is most indicated
BACKGROUND Lipid-lowering therapy is recommended for secondary prevention in people with coronary artery disease .
It may also reduce cardiovascular events and /or local disease progression in people with lower limb peripheral arterial disease ( PAD ) .
OBJECTIVES To assess the effects of lipid-lowering therapy on all-cause mortality , cardiovascular events and local disease progression in patients with PAD of the lower limb .
Olive oil- and fish oil-enriched diets modify plasma lipids and susceptibility of LDL to oxidative modification in free-living male patients with peripheral vascular disease: the Spanish Nutrition Study.
The present study describes a clinical trial in which Spanish patients suffering from peripheral vascular disease ( Fontaine stage II ) were given specific lipid supplements . Design ed as a longitudinal intervention study , patients were provided with olive oil for 3 months , followed by a 3 month wash-out period , then supplemented with a combination of fish oil and olive oil for the final 3 months . Changes in plasma and lipoprotein fatty acid composition and susceptibility of LDL to in vitro oxidation were examined . Furthermore , lipid-supplement-induced changes in LDL properties were measured as relative electrophoretic mobility and macrophage uptake . In addition , thirteen patients not provided with olive oil and fish oil were included as a control group and twenty healthy age-matched individuals were used as a reference group . A complete clinical study and a nutritional survey concerning food habits and lifestyle were performed every 3 months . Yao indices and claudicometry did not change significantly with dietary intervention although changes in plasma lipid composition suggested an improvement in the condition of the patients . The intake of the fish-oil supplement result ed in significantly increased plasma levels of eicosapentaenoic acid ( 20:5n-3 ) and docosahexaenoic acid ( 22:6n-3 ) in comparison with baseline concentrations , olive-oil and control groups . Fish-oil consumption significantly decreased plasma triacylglycerol levels compared with the olive-oil period , control and reference groups . The susceptibility of LDL to Cu-mediated oxidation was lower in the patients consuming olive oil and the fish-oil supplement than in the control group , and the uptake of LDL by macrophages was significantly lower in the group supplemented with fish oil . In conclusion , consumption of olive oil together with a dietary supplement of fish oil may be useful in the nutritional management of patients suffering from peripheral vascular disease in terms of increasing plasma n-3 long-chain polyunsaturated fatty acids and decreasing susceptibility of LDL to oxidation
Lipid-lowering therapy is effective in reducing cardiovascular mortality and morbidity in people with PAD .
It may also improve local symptoms .
Until further evidence on the relative effectiveness of different lipid-lowering agents is available , use of a statin in people with PAD and a blood cholesterol level > /=3.5 mmol/litre is most indicated
BACKGROUND Lipid-lowering therapy is recommended for secondary prevention in people with coronary artery disease .
It may also reduce cardiovascular events and /or local disease progression in people with lower limb peripheral arterial disease ( PAD ) .
OBJECTIVES To assess the effects of lipid-lowering therapy on all-cause mortality , cardiovascular events and local disease progression in patients with PAD of the lower limb .