Conclusion The prevalence of sarcopenia depends mostly on the diagnostic cut-off points of different criteria .
Preoperative sarcopenia is a risk factor for both long-term and short-term outcomes
Background The impact of sarcopenia on the outcome of gastrointestinal ( GI ) oncological patients is still controversial .
We aim to discuss the prevalence of sarcopenia and its relation to the oncological outcome .
The Impact of Muscle and Adipose Tissue on Long-term Survival in Patients With Stage I to III Colorectal Cancer
BACKGROUND : Computed tomography-derived body composition parameters are emerging prognostic factors in colorectal cancer . OBJECTIVE : This study aim ed to determine the roles of sarcopenia , myosteatosis , and obesity as independent and overlapping parameters in stage I to III colorectal cancer . DESIGN : This is a retrospective cohort study from a prospect ively collected data base . Multivariate Cox proportional hazards models were performed to assess the associations between body composition parameters and survival . SETTING S : All patients were seen in a tertiary care cancer center . PATIENTS : Adult patients with stage I to III colorectal cancer , undergoing curative resection from 2007 to 2009 , were included . INTERVENTION : Computed tomography-derived quantification of skeletal muscle and adipose tissues was used to determine population -specific cutoffs for sarcopenia , myosteatosis , and total adiposity . MAIN OUTCOME MEASURES : Primary outcome measures were overall , recurrence-free , and cancer-specific survival . RESULTS : In the 968 patients included , there were a total of 254 disease  recurrences and 350 deaths . Body mass index and CT-derived measures of adiposity did not result in worse survival outcomes . Sarcopenia was independently predictive of worse overall ( HR , 1.45 ; 95 % CI , 1.16 - 1.84 ) , recurrence-free ( HR , 1.32 ; 95 % CI , 1.00–1.75 ) , and cancer-specific survival ( HR , 1.46 ; 95 % CI , 1.09–1.94 ) in a multivariate model . Myosteatosis was also independently predictive of overall survival ( HR , 1.53 ; 95 % CI , 1.19–1.97 ) . In a model considering joint effects of sarcopenia and myosteatosis , the presence of both predicted the worst overall ( HR , 2.23 ; 95 % CI , 1.62–3.06 ) , recurrence-free ( HR , 1.53 ; 95 % CI , 1.06–2.21 ) , and cancer-specific survival ( HR , 2.40 ; 95 % CI , 1.69–3.42 ) in a multivariate model . LIMITATIONS : The limitations of this study are inherent in retrospective observational studies . CONCLUSIONS : Sarcopenia and myosteatosis are independent predictors of worse survival in stage I to III colorectal cancer , and their joint effect is highly predictive of reduced overall , recurrence-free , and cancer-specific survival . See Video Abstract at http://links.lww.com/DCR/A923
Conclusion The prevalence of sarcopenia depends mostly on the diagnostic cut-off points of different criteria .
Preoperative sarcopenia is a risk factor for both long-term and short-term outcomes
Background The impact of sarcopenia on the outcome of gastrointestinal ( GI ) oncological patients is still controversial .
We aim to discuss the prevalence of sarcopenia and its relation to the oncological outcome .