Lipid-lowering therapy is effective in reducing cardiovascular mortality and morbidity in people with PAD .
It may also improve local symptoms .
Until further evidence on the relative effectiveness of different lipid-lowering agents is available , use of a statin in people with PAD and a blood cholesterol level > /=3.5 mmol/litre is most indicated
BACKGROUND Lipid-lowering therapy is recommended for secondary prevention in people with coronary artery disease .
It may also reduce cardiovascular events and /or local disease progression in people with lower limb peripheral arterial disease ( PAD ) .
OBJECTIVES To assess the effects of lipid-lowering therapy on all-cause mortality , cardiovascular events and local disease progression in patients with PAD of the lower limb .
Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation.
This double-blind study was design ed to examine and compare the effects of supplementing the existing diet with fish oil or olive oil on lipids and cell function in patients with peripheral vascular disease . Thirty-two patients with symptomatic and angiographically demonstrated peripheral vascular disease were screened , matched , and r and omly allocated to take either 15 g/d fish oil or olive oil for 4 weeks . Fish oil reduced serum triglyceride levels by 26 % , but increased total cholesterol levels due to a significant increase in both low-density lipoprotein cholesterol ( LDL-C ) and high-density lipoprotein-2 cholesterol ( HDL2-C ) . There was a nonsignificant decrease in HDL3-C levels .  Olive oil reduced total cholesterol levels , accountable to a significantly decrease in LDL-C levels . Serum thromboxane B2 ( TXB2 ) levels remained unchanged following fish oil , but were significantly increased by olive oil .  Urinary excretion of TXB2 and 6-keto-PGF1 alpha was unaffected by either oil supplement . Platelet aggregation , which was measured in platelet-rich plasma in response to two doses of collagen or platelet-activating factor ( PAF ) , was significantly reduced after fish oil , but was increased by olive oil . Following fish oil , there was a significant increase in eicosapentaenoic acid ( EPA , 20:5 ) and docosahexaenoic acid ( DHA , 22:6 ) levels and a decrease in arachidonic acid content of platelet phospholipids . The platelet fatty acid composition after olive oil was unchanged . Fish oil decreased neutrophil leukotriene B4 ( LTB4 ) generation following calcium ionophore stimulation by 33 % , while leukotriene B5 levels increased significantly . Neutrophil PAF production and plasma lyso-PAF were unaffected by either oil . ( ABSTRACT TRUNCATED AT 250 WORDS
Lipid-lowering therapy is effective in reducing cardiovascular mortality and morbidity in people with PAD .
It may also improve local symptoms .
Until further evidence on the relative effectiveness of different lipid-lowering agents is available , use of a statin in people with PAD and a blood cholesterol level > /=3.5 mmol/litre is most indicated
BACKGROUND Lipid-lowering therapy is recommended for secondary prevention in people with coronary artery disease .
It may also reduce cardiovascular events and /or local disease progression in people with lower limb peripheral arterial disease ( PAD ) .
OBJECTIVES To assess the effects of lipid-lowering therapy on all-cause mortality , cardiovascular events and local disease progression in patients with PAD of the lower limb .