Subgroup analysis suggested the existence of liver disease at baseline , synbiotics supplementation and duration of supplementation ≥ 8 weeks result ed in more pronounced improvement in liver function enzymes than their counterparts .
Conclusions Probiotics and synbiotics may be suggested as supplements to improve serum concentration of liver enzymes , especially when synbiotics administered for a period ≥ 8 weeks and in individuals with liver disease
Purpose The gut – liver interaction suggests that modification of gut bacterial flora using probiotics and synbiotics may improve liver function .
This systematic review and meta- analysis aim ed to clarify the effect of probiotics and synbiotics consumption on the serum concentration of liver function enzymes .
An open-label randomized controlled trial of lactulose and probiotics in the treatment of minimal hepatic encephalopathy
Background and aim Minimal hepatic encephalopathy ( MHE ) is associated with poor quality of life and increased work disability . Treatment with lactulose and probiotics has shown some benefit . We compared lactulose with probiotics and a combination of lactulose plus probiotics in the treatment of MHE . Patients and methods One hundred and ninety cirrhotic patients without overt encephalopathy [ Child 's A grade 71 patients ( 37.4 % ) , Child 's B grade 72 patients ( 37.9 % ) , Child 's C grade 47 patients ( 24.7 % ) ] were evaluated by psychometry ( number connection tests A and B or figure connection tests A and B ) and P300 auditory event-related potential ( P300ERP ) . MHE was diagnosed by abnormal psychometry and /or P300ERP . Patients were r and omized to receive lactulose [ group A ( n=35 ) : dose 30–60 ml/day ] , probiotics [ group B ( n=35 ) : dose 1 capsule three times/day , each capsule contained Streptococcus faecalis 60 million , Clostridium butyricum 4 million , Bacillus mesentricus 2 million , lactic acid bacillus 100 million ] and lactulose plus probiotics [ group C ( n=35 ) ] for 1 month . Response was defined by normalization of the abnormal test parameters . Results MHE was diagnosed in 105 ( 55.2 % ) patients . Of the 105 patients , 75 ( 71 % ) had both abnormal psychometry and P300ERP , whereas 90 ( 86 % ) had abnormal psychometry alone , and 89 patients ( 85 % ) had abnormal P300ERP alone . Significant improvement was seen in abnormal psychometry tests ( group A : n=31 vs. n=12 , group B : n=29 vs. n=14 , group C : n=30 vs. n=10 ) , P300ERP ( group A : 376.8±22.3 vs. 344.3±30.6 ms , group B : 385.4±28.5 vs. 355.5±27.9 ms , group C : 387.7±27.5 vs. 347.7±31.5 ms ) and venous ammonia levels ( group A : 102.3±63.1 vs. 69.3±33.3 μmol/l , group B : 108.2±37.5 vs. 75.7±33.0 μmol/l , group C : 96.3±27.7 vs. 68.7±28.4 μmol/l ) in lactulose , probiotics and a combination of lactulose plus probiotics groups after treatment . Normalization of abnormal psychometry and P300ERP was seen in 54.8 , 51.6 and 56.6 % of patients treated with lactulose , probiotics and lactulose plus probiotics groups , respectively . Conclusion A total of 55 % of the patients with cirrhosis had MHE . Lactulose or probiotics or combinations of both are equally effective in the treatment of MHE
Subgroup analysis suggested the existence of liver disease at baseline , synbiotics supplementation and duration of supplementation ≥ 8 weeks result ed in more pronounced improvement in liver function enzymes than their counterparts .
Conclusions Probiotics and synbiotics may be suggested as supplements to improve serum concentration of liver enzymes , especially when synbiotics administered for a period ≥ 8 weeks and in individuals with liver disease
Purpose The gut – liver interaction suggests that modification of gut bacterial flora using probiotics and synbiotics may improve liver function .
This systematic review and meta- analysis aim ed to clarify the effect of probiotics and synbiotics consumption on the serum concentration of liver function enzymes .