SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .
Fluoxetine treatment of cocaine-dependent patients with major depressive disorder.
Sixty-eight male and female individuals with both DSM-IV diagnoses of cocaine dependence and major depressive disorder were r and omly assigned to one of two medication conditions ( placebo vs. 40 mg per day ) as part of a double-blind , placebo-controlled clinical efficacy trial of fluoxetine for the treatment of this dual diagnosis . During the 12-week outpatient treatment phase all participants also received individual cognitive-behavioral psychotherapy targeting both cocaine use and depression . Depressive symptoms remitted as a function of time in treatment , with no significant medication effects found . Fewer cocaine positive urines were found during the first 6 weeks of treatment in the placebo group compared with the 40-mg group . Cocaine use and depressive symptoms during treatment were significantly correlated . The findings fail to support the role of fluoxetine for treatment of cocaine use and depression in dually-diagnosed patients
SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .