The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Captopril at 50 mg as well as at 100 mg once a day reduces blood pressure for up to 24 h: a double‐blind randomized crossover study in mild to moderate hypertensives
The extent and the duration of the antihypertensive effect of captopril , given once a day at a dose of 50 mg , compared with placebo and with the 100 mg once daily dose was studied in 30 mild or moderate uncomplicated essential hypertensives ( mean ± s.e.m . age 52.0 ± 1.5 years ) , who responded ( mean blood pressure decrease > 10 % ) to a single oral dose ( 12.5 mg ) of captopril . According to a r and omized , double-blind , crossover design , they were given 50 mg captopril four times a day , 100 mg captopril four times a day or matched placebo for 1 month . At the end of each treatment period blood pressure and heart rate were measured every 30 min from 3 h before to 2 h after the last dose . Although the heart rate did not change , mean blood pressure after the 50− and 100-mg doses of captopril was consistently significantly ( P ± 0.05 ) lower than after placebo . The hypotensive effect peaked at the second hour and was still significant 24 h after dosing without any significant differences between the 50− and the 100-mg doses . These findings indicate that captopril , given chronically once a day at a dose of 50 mg to mild to moderate hypertensive responders , exerts its hypotensive effect up to 24 h and that doubling the dose does not increase either the extent or the duration of its action
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .