In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .
Combination chemotherapy with mastectomy or radiotherapy for stage III breast carcinoma: a Cancer and Leukemia Group B study.
One hundred thirteen evaluable patients with previously untreated stage III breast carcinoma were treated with three monthly cycles of cyclophosphamide ( CYC ) , doxorubicin ( DOX ) , 5-fluorouracil ( 5-FU ) , vincristine ( VCR ) , and prednisone ( PRED ) ( CAFVP ) . Subsequently , 91 ( 81 % ) were deemed operable . Patients were then r and omized to receive surgery or radiotherapy ( RT ) to determine which of these modalities afforded better local tumor control . All patients also received 2 additional years of CAFVP in a further attempt to eradicate local disease and systemic micrometastases . Forty-one of the r and omized patients have relapsed . Approximately half of the initial relapses in each arm were local . The overall duration of disease control was similar following either modality , with a median of 29.2 months for surgery patients and 24.4 months for RT patients . Similarly , there was no major difference in survival related to r and omized treatment with an overall median of 39 months ( median follow-up 37 months ) . Pre- or perimenopausal status and inflammatory disease were associated with shorter disease control and survival . Treatment was generally well tolerated and toxicity was acceptable . This study demonstrates that prolonged control of stage III breast carcinoma  can be achieved with combined modality therapy in which cytotoxic chemotherapy precedes and follows treatment directly primarily at the breast tumor , using either surgery or RT . Nevertheless , new regimens must be design ed if significant advances that may lead to the cure of this disease are to be achieved
In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .