In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
Glycemic Effect of a Single High Oral Dose of the Novel Sweetener Sucralose in Patients With Diabetes
OBJECTIVE To examine the effect of a single high oral dose of the novel noncaloric sweetener sucralose on short-term glucose homeostasis in patients with IDDM or NIDDM . RESEARCH DESIGN AND METHODS A total of 13 IDDM and 13 NIDDM patients with glycosylated hemoglobin levels < 10 % completed this double-blind cross-over study . After an overnight fast , patients were administered opaque capsules containing either 1,000 mg sucralose or cellulose placebo , followed by a st and ardized 360-kcal liquid breakfast . Plasma glucose and serum C-peptide levels were measured over the next 4 h. RESULTS Regardless of the type of diabetes , areas under the curves for changes of plasma glucose and serum C-peptide levels after sucralose administration were not significantly different from those after placebo . During test meals with sucralose , one episode of symptomatic hypoglycemia occurred in each of three IDDM patients , but these episodes were not considered the result of sucralose administration . CONCLUSIONS The present results support the conclusion that sucralose consumption does not adversely affect short-term blood glucose control in patients with diabetes
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .