Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial.
There is mounting evidence that specific dietary polyphenols can enhance vascular health by augmenting nitric oxide . Our aim was to investigate the acute effects of chlorogenic acid , an important dietary phenolic acid present in coffee ( 400 mg , equivalent to 2 cups of coffee ) , on nitric oxide status , endothelial function , and blood pressure .  Healthy men and women ( n = 23 ) were recruited to a r and omized , double-blind , placebo-controlled , crossover trial . Chlorogenic acid result ed in significantly higher plasma concentrations of chlorogenic acid ( P < 0.001 ) . Relative to control , the mean post-treatment systolic blood pressure ( -2.41 mmHg , 95 % CI : -0.03 , -4.78 ; P = 0.05 ) and diastolic blood pressure ( -1.53 mmHg , 95 % CI : -0.05 , -3.01 ; P = 0.04 ) were significantly lower with chlorogenic acid . Markers of nitric oxide status ( P > 0.10 ) and the measure of endothelial function ( P = 0.60 ) were not significantly influenced . Chlorogenic acid can lower blood pressure acutely , an effect that , if sustained , would benefit cardiovascular health
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .