The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Ambulatory blood pressure monitoring can play an integral role in patient selection, dosage adjustment and efficacy assessment in clinical trials of antihypertensive agents
Objective To evaluate the efficacy and duration of action of the angiotensin converting enzyme inhibitor quinapril hydrochloride by using ambulatory blood pressure monitoring . Design Eleven centers in the USA and Canada entered 155 patients with previously diagnosed hypertension into a 4-week placebo-baseline phase . Twenty patients ( 13 % ) with elevated diastolic blood pressure ( DBP ) only by cuff measurement were excluded from entry into a double-blind test based on ambulatory blood pressure monitoring , and 135 patients with a mean waking blood pressure of 155/100 mmHg were assigned r and omly to receive either quinapril or placebo once a day for 8 weeks , with optional titration to a higher dose after 4 weeks , based on the DBP response assessed by repeat ambulatory blood pressure monitoring only . Results Quinapril therapy produced highly significant decrease in mean daytime DBP compared with placebo . The antihypertensive effect of quinapril was evident over 24 h , with 50 % of the peak effect remaining at the trough . After 4 weeks of treatment 49 % of the patients in the quinapril group were titrated to the higher dose compared with 86 % of the patients who had been receiving placebo . More than 70 % of the patients in the quinapril group who remained at the low dose would have been titrated to the higher dose based solely on the clinic DBP measurements . Conclusions The use of ambulatory blood pressure monitoring in the present study reduced the false-positive response to placebo and lessened the likelihood of titrating patients to the higher dose of quinapril in comparison with the number that would have been so treated based on clinic blood pressure measurements alone . More importantly , our results suggest that the convenience , ease and relatively low cost of traditional cuff blood pressure measurement should be weighed against the potential shortcomings of the method
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .