There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .
Effect of iron-supplemented total parenteral nutrition in patients with iron deficiency anemia.
Iron deficiency anemia is common among hospitalized patients , and blood losses from diagnostic phlebotomy increase the likelihood of a negative iron balance . The role for iron supplementation of total parenteral nutrition ( TPN ) in these patients is unclear . Twenty-three patients with iron deficiency anemia were identified . Twelve patients were r and omized to receive TPN without iron ( group 1 ) and 11 received TPN supplemented with 10 mg of iron as iron dextran daily ( group 2 ) . Both groups were matched for age , serum iron studies , red cell indices , and hemogram . After a 7-d period , the mean serum iron in group 2 increased from 10 to 26 micrograms/dL , with an increased transferrin saturation from 7.3 to 15.3 % ( each , p < 0.05 ) . No changes in total iron binding capacity , ferritin , reticulocyte count , hemoglobin , hematocrit , or mean corpuscular volume were observed in the two groups . The incidence of infectious complications was not different between both groups . We conclude that iron supplementation of TPN appears safe and is effective in increasing serum iron levels . The use of iron-supplemented short-term TPN needs to be further studied given no change in red cell indices , hemoglobin , hematocrit , or transfusion requirement
There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .