The present systematic review shows that , with the exception of laparoscopic surgery , objective evidence of the effect of individual components of ERAS protocol s in reducing the stress response following colorectal surgery is limited
Abstract Enhanced Recovery or Fast Track Recovery after Surgery protocol s ( ERAS ) have significantly changed perioperative care following colorectal surgery and are promoted as reducing the stress response to surgery .
Comparison of immunologic outcomes of laparoscopic vs open approaches in clinical stage III colorectal cancer
Purpose Improved survival in patients with stage III colon cancer after a laparoscopic colectomy ( LC )  has been reported by Lacy et al. ( Lancet 359:2224–2229 , 6 ) , and preserved immunity was suggested as the reason for the survival advantage . The aim of our study was to clarify the existence of an immunological benefit after laparoscopic colon cancer surgery ( LC ) compared to open colon surgery ( OC ) . Methods From January 2006 to November 2007 , 74 patients with clinical stage III colon cancer were prospect ively assigned to undergo a LC ( n = 35 ) or an OC ( n = 39 ) . The immune factors were examined preoperatively , and on the first and fifth days postoperatively ( POD1 and POD5 ) . Results The cellular immune factors were significantly decreased ; however , there was no significant difference between the LC and OC groups except for the mHLA-DR . The LC group had a better preserved mHLA-DR on POD5 than did the OC group ( p = 0.015 ) , in addition to a faster recovery ( p < 0.005 ) . Conclusion The mHLA-DR on POD5 was affected less by the LC compared to the OC . The LC demonstrated minimal immunological advantage when compared to the OC . However , further study is required to clarify the immunological benefits of the LC on colorectal cancer prognosis
The present systematic review shows that , with the exception of laparoscopic surgery , objective evidence of the effect of individual components of ERAS protocol s in reducing the stress response following colorectal surgery is limited
Abstract Enhanced Recovery or Fast Track Recovery after Surgery protocol s ( ERAS ) have significantly changed perioperative care following colorectal surgery and are promoted as reducing the stress response to surgery .