There was no significant change in the γGT levels .
Significant differences were not found .
CONCLUSION Silymarin minimally reduced , but without clinical relevance , the serum levels of ALT and AST .
AIM To evaluate the effect of silymarin on the serum levels of alanine aminotransferase ( ALT ) , aspartate aminotransferase ( AST ) and gamma glutamyl transpeptidase ( γGT ) in patients with liver diseases .
One year follow-up of patients treated with misoprostol in acute phase of viral hepatitis B.
The study was undertaken to determine the long-term effect of misoprostol , on  hepatitis B virus ( HBV ) elimination  in patients treated during acute phase of viral hepatitis B. Forty male patients were evaluated 12 months after treatment with misoprostol ( M-group ) or sylimarin ( S-group ) .  HBsAg clearance , as an indicator of HBV elimination , and serum bilirubin concentration , prothrombin index , and activities of alanine transaminase , aspartate transaminase , alkaline phosphatase as well as gamma glutamyltranspeptidase were analysed . At the end of treatment phase , improvement of liver function demonstrated through these biochemical indices was faster in M-group . After 12 months of follow-up HBsAg was cleared in all misoprostol treated patients and in 85 % among S-group . Moreover misoprostol treatment result ed with normalization of bilirubin concentration and enzymes activity in all patients . Two among sylimarin treated patients ( both HBsAg positive ) , had transaminases activities elevated over 100 U/l , that result ed with significantly higher values than in M-group . These results confirm beneficial effect of misoprostol treatment in patients with liver injury , but promising effect on HBV clearance should be confirmed in a study involving more patients
There was no significant change in the γGT levels .
Significant differences were not found .
CONCLUSION Silymarin minimally reduced , but without clinical relevance , the serum levels of ALT and AST .
AIM To evaluate the effect of silymarin on the serum levels of alanine aminotransferase ( ALT ) , aspartate aminotransferase ( AST ) and gamma glutamyl transpeptidase ( γGT ) in patients with liver diseases .