There was no superiority of a specific approach .
Weight gains were more rapid in adolescents and inpatient treatment .
Background : The aim of the study was a systematic review of studies evaluating psychotherapeutic treatment approaches in anorexia nervosa and to compare their efficacy .
Weight gain was chosen as the primary outcome criterion .
We also aim ed to compare treatment effects according to service level ( inpatient vs. outpatient ) and age group ( adolescents vs. adults ) .
The Maudsley Outpatient Study of Treatments for Anorexia Nervosa and Related Conditions (MOSAIC): Comparison of the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with specialist supportive clinical management (SSCM) in outpatients with broadly defined anorexia nervosa: A randomize
OBJECTIVE Anorexia nervosa ( AN ) in adults has poor outcomes , and treatment evidence is limited . This study evaluated the efficacy and acceptability of a novel , targeted psychological therapy for AN ( Maudsley Model of Anorexia Nervosa Treatment for Adults ; MANTRA ) compared with Specialist Supportive Clinical Management ( SSCM ) . METHOD One hundred forty-two out patients with broadly defined AN ( body mass index [ BMI ] ≤ 18.5 kg/m² ) were r and omly allocated to receive 20 to 30 weekly sessions ( depending on clinical severity ) plus add-ons ( 4 follow-up sessions , optional sessions with dietician and with carers ) of MANTRA ( n = 72 ) or SSCM ( n = 70 ) . Assessment s were administered blind to treatment condition at baseline , 6 months , and 12 months after r and omization . The primary outcome was BMI at 12 months . Secondary outcomes included eating disorders symptomatology , other psychopathology , neuro-cognitive and social cognition , and acceptability . Additional service utilization was also assessed . Outcomes were analyzed using linear mixed models . RESULTS Both treatments result ed in significant improvements in BMI and reductions in eating disorders symptomatology , distress levels , and clinical impairment over time , with no statistically significant difference between groups at either 6 or 12 months . Improvements in neuro-cognitive and social-cognitive measures over time were less consistent . One SSCM patient died . Compared with SSCM , MANTRA patients rated their treatment as significantly more acceptable and credible at 12 months . There was no significant difference between groups in additional service consumption . CONCLUSIONS Both treatments appear to have value as first-line outpatient interventions for patients with broadly defined AN . Longer term outcomes remain to be evaluated
There was no superiority of a specific approach .
Weight gains were more rapid in adolescents and inpatient treatment .
Background : The aim of the study was a systematic review of studies evaluating psychotherapeutic treatment approaches in anorexia nervosa and to compare their efficacy .
Weight gain was chosen as the primary outcome criterion .
We also aim ed to compare treatment effects according to service level ( inpatient vs. outpatient ) and age group ( adolescents vs. adults ) .