In studies included in this meta- analysis , probiotic administration was associated with a reduction in NEC-related mortality
Aim of the study Probiotic administration to preterm infants has the potential to prevent necrotising enterocolitis ( NEC ) .
Data from r and omised controlled trials ( RCT ) are conflicting but meta-analyses seem to support this intervention .
To date , these analyses have not focused on surgical NEC .
We aim ed to determine the effect of probiotic administration  to preterm infants on prevention of surgical NEC .
Role of Enteric Supplementation of Probiotics on Late-onset Sepsis by Candida species in Preterm Low Birth Weight Neonates: A Randomized, Double Blind, Placebo-controlled Trial
Background : The increase in invasive fungal infections ( IFIs ) in neonatal intensive care unit ( NICU ) is jeopardizing the survival of preterm neonates . Probiotics modulating the intestinal microflora of preterm neonates may minimize enteral fungal colonization . Aims : This study was to examine whether probiotic supplementation in neonates reduced fungal septicemia . Material s and Methods : This prospect i ve , r and omized , double blind trial investigating the  supplementation of preterm infants with a probiotic  was done from May 2012 to April 2013 , with 112 subjects r and omized into two groups . Primary outcome : Decreased fungal colonization in gastrointestinal tract . Others : Incidence of late onset septicemia ; duration of the primary hospital admission ; number of days until full enteral feeds established . Results : Full feed establishment was earlier in probiotics group compared to placebo group ( P = 0.016 ) . The duration of hospitalization was less in the probiotic group ( P = 0.002 ) . Stool fungal colonization , an important outcome parameter was 3.03 ± 2.33 × 105 colony formation units ( CFU ) in the probiotics group compared to 3 ± 1.5 × 105 CFU in the placebo group ( P = 0.03 ) . Fungal infection is less in the study group ( P = 0.001 ) . Conclusion : The key features of our study were reduced enteral fungal colonization , reduce invasive fungal sepsis , earlier establishment of full enteral feeds , and reduced duration of hospital stay in the probiotics group
In studies included in this meta- analysis , probiotic administration was associated with a reduction in NEC-related mortality
Aim of the study Probiotic administration to preterm infants has the potential to prevent necrotising enterocolitis ( NEC ) .
Data from r and omised controlled trials ( RCT ) are conflicting but meta-analyses seem to support this intervention .
To date , these analyses have not focused on surgical NEC .
We aim ed to determine the effect of probiotic administration  to preterm infants on prevention of surgical NEC .