All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .
Prognostic significance of geriatric assessment in combination with laboratory parameters in elderly patients with aggressive non-Hodgkin lymphoma
Abstract The age-adjusted International Prognostic Index ( IPI ) is an important prognostic factor for patients with non-Hodgkin lymphoma ( NHL ) . We investigated whether a geriatric assessment ( GA ) is of additional prognostic value in NHL . In this prospect i ve cohort study of 44 patients aged 70 years or older with NHL receiving rituximab , cyclophosphamide , doxorubicin , vincristine and prednisone ( R-CHOP )  , a GA was administered before the start of chemotherapy . GA was composed of the  Mini Nutritional Assessment ( MNA ) , Groningen Frailty Indicator ( GFI ) , Informant Question naire on Cognitive Decline in the Elderly ( IQCODE ) , Mini Mental State Examination ( MMSE ) and levels of albumin , creatinine , lactate dehydrogenase ( LDH ) and hemoglobin . Multivariate analyses were performed using logistic regression and the Cox regression model . After adjustment for sex , age , comorbidity and univariate laboratory values with p ≤ 0.1 , abnormal MNA and GFI scores and low hemoglobin level were associated with not being able to complete the intended chemotherapy : odds ratio ( OR ) 8.29 ( 95 % confidence interval [ CI ] : 1.24–55.6 ; p = 0.03 ) , 9.17 ( 95 % CI : 1.51–55.8 ; p = 0.02 ) and 5.41 ( 95 % CI : 0.99–29.8 ; p = 0.05 ) , respectively . Adjusted for sex , age , comorbidity , age-adjusted IPI and univariate laboratory values with p ≤ 0.1 , frailty by GFI and low hemoglobin were associated with worse survival , with a hazard ratio ( HR ) of mortality of 2.55 ( 95 % CI : 1.07–6.10 ; p = 0.04 ) and 4.90 ( 95 % CI : 1.76–13.7 ; p = 0.002 ) , respectively . We conclude that ( risk of ) malnutrition , measured with the MNA , frailty , measured with the GFI , and low hemoglobin level had additional predictive value for early treatment withdrawal , and GFI and hemoglobin were , independent of the age-adjusted IPI , predictive for an increased mortality risk
All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .