Atrial fibrillation history is statistically significantly associated with adverse major clinical outcomes in ICD-implanted HF patients .
Patients with AF have a higher risk of all-cause mortality , appropriate , and inappropriate ICD interventions compared with patients with no AF history .
AIMS To assess the association between atrial fibrillation ( AF ) and all-cause mortality and implantable cardioverter-defibrillators ( ICDs ) therapies  in heart failure ( HF ) patients with reduced ejection fraction and an ICD implanted .
Safety and efficacy of strategic implantable cardioverter-defibrillator programming to reduce the shock delivery burden in a primary prevention patient population.
AIMS Strategically chosen ventricular tachycardia (VT)/ventricular fibrillation ( VF ) detection and therapy parameters aim ed at reducing shock deliveries were proven effective in studies that utilized single manufacturer devices with a follow-up of up to 1 year . Whether these beneficiary effects can be generalized to additional manufacturers and be maintained for longer periods is to be determined . Our aim was to evaluate the durability and applicability of the programming of strategic implantable cardioverter-defibrillators ( ICDs ) of various manufacturers , which is aim ed at reducing the shock delivery burden in primary prevention ICD recipients . METHODS AND RESULTS A retrospective analysis of prospect ively collected data of 300 ICD recipients of various manufacturers was conducted ; 160 devices were strategically programmed to reduce shocks and 140 were not . The primary endpoint was the composite of death and appropriate shocks . Additional outcomes were inappropriate shocks , syncope events , and non-sustained VTs . At a median follow-up of 24 months , 19 patients died , 31 received appropriate shocks , and 41 received inappropriate shocks . Multivariate analysis showed that strategic programming dedicated to shock reduction was associated with a 64 % risk reduction in the primary endpoint [ hazard ratio ( HR ) : 0.13 - 0.93 ; P = 0.03 ] and a 70 % reduction in inappropriate shock deliveries ( HR : 0.16 - 0.72 ; P = 0.01 ) . Very few syncope events occurred ( five patients , 1.6 % ) , and there was no between-group difference in this outcome . CONCLUSION Utilization of strategically chosen VT/VF detection and therapy parameters was found to be effective and safe in ICDs of various manufacturers at a median follow-up period of 2 years among primary prevention patients
Atrial fibrillation history is statistically significantly associated with adverse major clinical outcomes in ICD-implanted HF patients .
Patients with AF have a higher risk of all-cause mortality , appropriate , and inappropriate ICD interventions compared with patients with no AF history .
AIMS To assess the association between atrial fibrillation ( AF ) and all-cause mortality and implantable cardioverter-defibrillators ( ICDs ) therapies  in heart failure ( HF ) patients with reduced ejection fraction and an ICD implanted .