There were no significant effects of organisational  interventions on lipid profile , HbA1c , medication adherence or recurrent cardiovascular events .
Pooled results indicated that educational interventions were not associated with clear differences in any of the review outcomes .
The estimated effects of organisational interventions were compatible with improvements and no differences in several modifiable risk factors .
BACKGROUND People with stroke or transient ischaemic attack ( TIA ) are at increased risk of future stroke and other cardiovascular events .
Evidence -based strategies for secondary stroke prevention have been established .
However , the implementation of prevention strategies could be improved .
OBJECTIVES To assess the effects of stroke service interventions for implementing secondary stroke prevention strategies on modifiable risk factor control , including patient adherence to prescribed medications , and the occurrence of secondary cardiovascular events .
Multifactorial cardiovascular disease prevention in patients aged 75 years and older: A randomized controlled trial: Drugs and Evidence Based Medicine in the Elderly (DEBATE) Study.
BACKGROUND The number of patients aged 75 + years with cardiovascular diseases ( CVD ) is increasing , but few studies of secondary prevention in this age group exist . The aim of the Drug and Evidence Based Medicine in the Elderly ( DEBATE ) study is to test the applicability and effectiveness of established CVD treatments in elderly patients . METHODS From 1998 to 2000 , population -based postal surveys were performed in Helsinki , Finl and , including the age groups 75 , 80 , 85 , 90 , and 95 years ( n = 4821 ) . Of the 812 individuals reporting any atherosclerotic disease , 400 patients ( 66 % of those eligible ) were included in a r and omized trial . In the intervention group , CVD treatments will be individualized according to current guidelines . A control group will receive the usual care . The trial period will last 2 years with a 3-year extension . The primary end point will be a composite of major CVD . In addition , a number of secondary end points will be recorded , including permanent institutionalization , decline in cognitive and physical function , and quality of life . RESULTS During 2000 , 400 home-dwelling patients were r and omized to the intervention ( n = 199 ) and control ( n = 201 ) groups . The mean age is 80.2 years and 65.3 % are women . Of the participants , 82 % have coronary heart disease ( 41 % with history of myocardial infa rct ion ) , 37 % history of stroke , 19 % non-insulin-dependent diabetes mellitus , and 45 % hypertension , and 6 % are current smokers . Before r and omization , 67 % used aspirin , 40 % b-blockers , 14 % angiotensin-converting enzyme inhibitors , 36 % nitrates , and 20 % lipid-lowering drugs . The groups were well balanced at baseline . CONCLUSION We have successfully r and omized elderly patients with a high degree of comorbidity into a multifactorial CVD prevention trial
There were no significant effects of organisational  interventions on lipid profile , HbA1c , medication adherence or recurrent cardiovascular events .
Pooled results indicated that educational interventions were not associated with clear differences in any of the review outcomes .
The estimated effects of organisational interventions were compatible with improvements and no differences in several modifiable risk factors .
BACKGROUND People with stroke or transient ischaemic attack ( TIA ) are at increased risk of future stroke and other cardiovascular events .
Evidence -based strategies for secondary stroke prevention have been established .
However , the implementation of prevention strategies could be improved .
OBJECTIVES To assess the effects of stroke service interventions for implementing secondary stroke prevention strategies on modifiable risk factor control , including patient adherence to prescribed medications , and the occurrence of secondary cardiovascular events .