The results of the present meta- analysis support that melatonin supplementation could be effective on ameliorating of inflammatory mediators
Inflammatory processes are involved in chronic diseases .
It has been suggested that melatonin reduces inflammation by its radical scavenging properties ; however , the results of the previous studies are inconclusive .
The objective of the present meta- analysis is to determine the direction and magnitude of melatonin supplementation effect on inflammatory biomarkers .
The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double‐blinded, placebo‐controlled trial
BACKGROUND The aim of this clinical trial was to determine the effects of melatonin administration on disease severity and sleep quality in children diagnosed with atopic dermatitis ( AD ) . METHODS This r and omized , double-blinded , placebo-controlled trial was conducted by recruiting 70 patients , aged 6 - 12 years , who had been diagnosed with AD . Study participants were r and omly allocated into two intervention groups to receive either 6 mg/d melatonin supplements or placebo ( n = 35 each group ) for 6 weeks . Severity of disease was assessed using the scoring atopic dermatitis ( SCORAD ) and objective SCORAD indices . Sleep quality was evaluated by completing the Children 's Sleep Habits Question naire ( CSHQ ) . RESULTS Following 6 weeks of intervention , melatonin supplementation significantly improved SCORAD index ( β -3.55 ; 95 % CI , -6.11 , -0.98 ; P = 0.007 ) , objective SCORAD index ( β -3.23 ; 95 % CI , -5.08 , -1.38 ; P = 0.001 ) , serum total IgE levels ( β -153.94 ku/L ; 95 % CI , -260.39 , -47.49 ; P = 0.005 ) , and CSHQ scores ( β -2.55 ; 95 % CI , -4.34 , -0.75 ; P = 0.006 ) . However , melatonin had no significant impact on pruritus scores , high-sensitivity C-reactive protein ( hs-CRP ) , sleep-onset latency , total sleep time , weight , and BMI  compared with placebo . CONCLUSIONS Overall , melatonin supplementation had beneficial effects on disease severity , serum total IgE levels , and CSHQ among children diagnosed with AD
The results of the present meta- analysis support that melatonin supplementation could be effective on ameliorating of inflammatory mediators
Inflammatory processes are involved in chronic diseases .
It has been suggested that melatonin reduces inflammation by its radical scavenging properties ; however , the results of the previous studies are inconclusive .
The objective of the present meta- analysis is to determine the direction and magnitude of melatonin supplementation effect on inflammatory biomarkers .