This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
The effects of oral vitamin D on insulin resistance in pre-diabetic patients
Background : Some epidemiological and interventional studies have shown the role of vitamin D on insulin secretion and resistance . A previous study in our center showed that intramuscular vitamin D decreases insulin sensitivity in pre-diabetic patients . We investigated the role of oral vitamin D on the insulin sensitivity index and insulin resistance in pre-diabetic patients . Material s and Methods : In a r and omized clinical trial , we divided 45 people with pre-diabetes aged 47.4 ± 6.6 ( range 33 - 61 ) years into three groups : group A subjects treated with 50,000 IU oral vitamin D and 500 mg calcium carbonate ( n = 21 ) , group B subjects treated with a single 300,000 IU intramuscular vitamin D and 500 mg calcium carbonate ( n = 9 ) , and group C subjects treated with 500 mg calcium carbonate alone ( n = 15 ) . Serum 25-hydroxyvitamin D [ 25(OH ) D ] was measured at baseline . If it was less than 75 nmol/l , 50,000 IU vitamin D was given weekly , and if serum 25(OH ) D was more than that , vitamin D was administered every 2 weeks . Before and after 12 weeks of treatment , a 75-g glucose tolerance test was performed . We used paired t-test and analysis of variance ( ANOVA ) to analyze the data . P values less than 0.05 were considered significant . Results : Mean ( SD ) of serum vitamin D increased from 77.5 ± 39.2 to 118.8 ± 56.3 nmol/l ( P = 0.009 ) in group A and from 80 ± 36 to 102.8 ± 43.3 nmol/l ( P = 0.053 ) in group B , and decreased from 44.8 ± 18.3 to 34.6 ± 13.9 nmol/l ( P = 0.06 ) in group C. Insulin sensitivity index ( Matsuda ) decreased from 11.4 ± 3 to 9.9 ± 3.2 ( P = 0.046 ) in group A , but in comparison with other groups , it was not significant . Conclusion : Oral vitamin D had no effect on insulin sensitivity in pre-diabetes patients in 12 weeks treatment . A r and omized double-blind study with a longer duration of treatment is suggested to investigate the effect of vitamin D on insulin resistance
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .