Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .
The effects of calcitriol with calcium carbonate supplementation on inflammatory biomarkers in chronic kidney disease patients’ with low vitamin D
Introduction Chronic kidney disease ( CKD ) patients ’ are at risk of low vitamin D and chronic inflammation . We studied the effect of 12 weeks calcitriol and calcium carbonate supplementation on inflammatory mediators serum ; interleukin-6 ( IL-6 ) , interleukin-10 ( IL-10 ) and highly sensitive C-reactive protein ( hs-CRP ) . Material and methods A prospect i ve r and omized study in CKD stages 2 - 4 with serum 25-hydroxyvitamin D ( 25-OHD ) levels < 30 ng/ml . Patients were r and omized into the Vitamin D + Calcium ( Vitamin D + C ) or Calcium group . Serums were analyzed at baseline , week 6 and 12 . Results Fifty patients , median age of 53 ( 13.5 ) years were recruited . Their median IL-10 was 13.35 ( 25.22 ) pg/ml . At week 12 , serum IL-6 was reduced in both groups ( p = 0.001 ) , serum IL-10 was maintained in the Vitamin D + C group ( p = 0.06 ) and was reduced in the Calcium group ( p = 0.001 ) . CKD-diabetic patients had reduced serum IL-6 in both study groups ( p = 0.001 ) and a reduction was seen in the Vitamin D + C group of the non-diabetics counterparts ( p = 0.005 ) . Serum IL-10 was reduced in the Calcium group ( p < 0.05 ) whereas serum 25-OHD rose in both groups , regardless of their diabetic status ( p < 0.05 ) . Conclusions Twelve weeks , calcitriol supplementation maintained IL-10 , had no effects on hs- CRP and had no additional benefit compared to calcium carbonate in reducing serum IL-6 except in non-diabetics
Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .