These meta-analyses found no statistically significant differences between the efficacy of propranolol and benzodiazepines regarding the short-term treatment of panic disorder with or without agoraphobia .
Also , no evidence was found for effects of propranolol on PTSD symptom severity through inhibition of memory reconsolidation .
In conclusion , the quality of evidence for the efficacy of propranolol at present is insufficient to support the routine use of propranolol in the treatment of any of the anxiety disorders
The effects of propranolol in the treatment of anxiety disorders have not been systematic ally evaluated previously .
The aim was to conduct a systematic review and meta- analysis of r and omised controlled trials , addressing the efficacy of oral propranolol versus placebo or other medication as a treatment for alleviating either state or trait anxiety in patients suffering from anxiety disorders .
Effect of beta-receptor blockade on anxiety with reference to the three-systems model of phobic behavior.
14 phobic subjects were given propranolol ( Inderal ) , atenolol ( Tenormin ) and placebo in a double-blind fashion according to a repeated measurement design . Subjects were exposed to their source of fear while their anxiety and cardiovascular responses ( heart rate , blood pressure and peripheral temperature ) were recorded . In accordance with the Three-Systems Model of fear and phobias , the subjects were divided into two groups of high and low physiological reactors , operationalized by the cardiovascular items in their anxiety pattern from a revised version of the Autonomic Perception Question naire ( APQ ) . It was found that beta-blockade had the predicted effect on heart rate and peripheral temperature while diastolic blood pressure was unaffected . The systolic blood pressure finally was lowered for the low cardiovascular reactors . The subjectively rated anxiety rose consistently during exposure . There was no general effect of the beta-blocking drugs on subjective anxiety . For the high cardiovascular reactors propranolol was associated with a higher anxiety level
These meta-analyses found no statistically significant differences between the efficacy of propranolol and benzodiazepines regarding the short-term treatment of panic disorder with or without agoraphobia .
Also , no evidence was found for effects of propranolol on PTSD symptom severity through inhibition of memory reconsolidation .
In conclusion , the quality of evidence for the efficacy of propranolol at present is insufficient to support the routine use of propranolol in the treatment of any of the anxiety disorders
The effects of propranolol in the treatment of anxiety disorders have not been systematic ally evaluated previously .
The aim was to conduct a systematic review and meta- analysis of r and omised controlled trials , addressing the efficacy of oral propranolol versus placebo or other medication as a treatment for alleviating either state or trait anxiety in patients suffering from anxiety disorders .