The benefits of antioxidants or DHA/EPA supplementation for CF , although observed in some studies , are not consistent enough to recommend routine use of these supplements .
Antioxidant micronutrients and essential fatty acids supplementation intake appears to have a protective effect in some diseases such as cardiovascular disease , cancer , and asthma .
The aim of this study was to perform a systematic review to evaluate the effects of these nutrients on nutritional and clinical outcomes of patients with cystic fibrosis ( CF ) .
This is a systematic review of r and omized clinical trials ( RCTs ) in CF .
Oral magnesium supplementation in children with cystic fibrosis improves clinical and functional variables: a double-blind, randomized, placebo-controlled crossover trial.
BACKGROUND Magnesium is one of the most important minerals in the body . Although some studies reported that patients with cystic fibrosis ( CF ) lack magnesium , no international study has assessed the importance of oral magnesium supplementation in CF patients . OBJECTIVE We prospect ively investigated the long-term effect of oral magnesium supplementation on respiratory muscle strength by using manuvacuometry and the Shwachman-Kulczycki ( SK ) score among children and adolescents with CF . DESIGN This double-blind , r and omized , placebo-controlled crossover study included 44 CF patients ( aged 7 - 19 y ; 20 males ) who were r and omly assigned to receive magnesium ( n = 22 ; 300 mg/d ) or placebo ( n = 22 ) for 8 wk with a 4-wk washout period between trials . All patients were undergoing conventional treatment of CF . The experimental protocol included clinical evaluation , assessment of urinary concentration of magnesium , and manuvacuometric measurements [ maximal inspiratory pressure ( MIP ) and maximal expiratory pressure ( MEP ) ] . MIP was the primary outcome . RESULTS Urinary magnesium increased after the administration of magnesium ( change : 36.38 mg/d after magnesium compared with 0.72 mg/d after placebo ; P < 0.001 ) . Moreover , MIP and MEP significantly improved only after magnesium administration ( change in MIP : 11 % predicted after magnesium compared with 0.5 % predicted after placebo ; change in MEP : 11.9 % predicted after magnesium compared with 0.8 % predicted after placebo ; P < 0.001 for both ) . Magnesium administration had a beneficial effect on clinical variables assessed by the SK score ( change : 4.48 points after magnesium compared with -1.30 points after placebo ; P < 0.001 ) . CONCLUSION Oral magnesium supplementation helped improve both the SK score and respiratory muscle strength in pediatric patients with CF
The benefits of antioxidants or DHA/EPA supplementation for CF , although observed in some studies , are not consistent enough to recommend routine use of these supplements .
Antioxidant micronutrients and essential fatty acids supplementation intake appears to have a protective effect in some diseases such as cardiovascular disease , cancer , and asthma .
The aim of this study was to perform a systematic review to evaluate the effects of these nutrients on nutritional and clinical outcomes of patients with cystic fibrosis ( CF ) .
This is a systematic review of r and omized clinical trials ( RCTs ) in CF .