There was no consistency among the protocol s regarding length of antibiotic use , discharge criteria , or use of home antibiotics following discharge .
Limiting duration of antibiotic use to3 days did not appear to be associated with higher rates of intraabdominal abscess or wound infection .
In the absence of higher-level evidence , shortening of antibiotic regimens following surgery for pediatric complicated appendicitis appears to be safe
The suitable duration of antibiotic use following appendectomy for advanced appendicitis in children is still debated .
A preliminary report of ticarcillin and clavulanate versus triple antibiotic therapy in children with ruptured appendicitis.
St and ard therapy for childhood ruptured appendicitis includes combination antibiotic therapy with ampicillin , gentamicin and clindamycin . Complicated dosing schedules and the possibility of aminoglycoside toxicity make alternatives desirable . One such alternative is Timentin ( a combination agent of ticarcillin disodium and clavulanate potassium ) . This agent has a more convenient dose schedule than st and ard therapy and eliminates the possibility of aminoglycoside ototoxicity and nephrotoxicity . It is active in vitro against most pathogens associated with ruptured appendicitis in children . The preliminary results of an ongoing prospect i ve , open label , r and omized trial comparing ticarcillin and clavulanate with ampicillin , gentamicin and clindamycin in childhood ruptured appendicitis are reported herein . While further evaluation is necessary , we have found single agent therapy with ticarcillin and clavulanate to be equivalent in safety and efficacy to st and ard combination therapy . Also discussed are the relative merits of immediate versus delayed primary closure of the abdominal wound after appendectomy
There was no consistency among the protocol s regarding length of antibiotic use , discharge criteria , or use of home antibiotics following discharge .
Limiting duration of antibiotic use to3 days did not appear to be associated with higher rates of intraabdominal abscess or wound infection .
In the absence of higher-level evidence , shortening of antibiotic regimens following surgery for pediatric complicated appendicitis appears to be safe
The suitable duration of antibiotic use following appendectomy for advanced appendicitis in children is still debated .