RESULTS Increased TFA intake did not result in significant changes in glucose or insulin concentrations .
Our analysis also showed the absence of publication bias and any dose-response relations between the ES and TFA intake .
Increased TFA intake does not result in changes in glucose , insulin , or triglyceride concentrations but leads to an increase in total and LDL-cholesterol and a decrease in HDL-cholesterol concentrations .
There is no evidence to support a potential benefit of the reduction of dietary TFA intake on glucose homeostasis
BACKGROUND Although evidence from cohort studies has suggested that trans fatty acid ( TFA ) consumption may be associated with insulin resistance and diabetes , r and omized placebo-controlled trials ( RCTs ) have yielded conflicting results .
OBJECTIVE In a meta- analysis , we combined all available RCTs that examined the role of  TFA intake  on  glucose homeostasis .
Dietary fat and meat intake in relation to risk of type 2 diabetes in men.
OBJECTIVE To examine dietary fat and meat intake in relation to risk of type 2 diabetes .  RESEARCH DESIGN AND METHODS We prospect ively followed 42,504 male participants of the Health Professionals Follow-Up Study who were aged 40 - 75 years and free of diagnosed diabetes , cardiovascular disease , and cancer in 1986 .  Diet was assessed by a vali date d food frequency question naire and up date d in 1990 and 1994 . During 12 years of follow-up , we ascertained 1,321 incident cases of type 2 diabetes . RESULTS Intakes of  total fat  ( multivariate RR for extreme quintiles 1.27 , CI 1.04 - 1.55 , P for trend=0.02 ) and saturated fat ( 1.34 , 1.09 - 1.66 , P for trend=0.01 ) were associated with a higher risk of type 2 diabetes . However , these associations disappeared after additional adjustment for BMI ( total fat RR 0.97 , CI 0.79 - 1.18 ; saturated fat 0.97 , 0.79 - 1.20 ) . Intakes of oleic acid , trans-fat , long-chain n-3 fat , and alpha-linolenic acid were not associated with diabetes risk after multivariate adjustment . Linoleic acid was associated with a lower risk of type 2 diabetes in men < 65 years of age ( RR 0.74 , CI 0.60 - 0.92 , P for trend=0.01 ) and in men with a BMI < 25 kg/m(2 ) ( 0.53 , 0.33 - 0.85 , P for trend=0.006 ) but not in older and obese men . Frequent consumption of processed meat was associated with a higher risk for type 2 diabetes ( RR 1.46 , CI 1.14 - 1.86 for > or = 5/week vs. < 1/month , P for trend < 0.0001 ) . CONCLUSIONS Total and saturated fat intake were associated with a higher risk of type 2 diabetes , but these associations were not independent of BMI . Frequent consumption of processed meats may increase risk of type 2 diabetes
RESULTS Increased TFA intake did not result in significant changes in glucose or insulin concentrations .
Our analysis also showed the absence of publication bias and any dose-response relations between the ES and TFA intake .
Increased TFA intake does not result in changes in glucose , insulin , or triglyceride concentrations but leads to an increase in total and LDL-cholesterol and a decrease in HDL-cholesterol concentrations .
There is no evidence to support a potential benefit of the reduction of dietary TFA intake on glucose homeostasis
BACKGROUND Although evidence from cohort studies has suggested that trans fatty acid ( TFA ) consumption may be associated with insulin resistance and diabetes , r and omized placebo-controlled trials ( RCTs ) have yielded conflicting results .
OBJECTIVE In a meta- analysis , we combined all available RCTs that examined the role of  TFA intake  on  glucose homeostasis .