RESULTS Weight loss was associated with a decline in CRP level .
Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level
BACKGROUND Several studies suggest that weight loss reduces C-reactive protein ( CRP ) level ; however , the consistency and magnitude of this effect has not been well characterized .
Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level .
Attenuation of inflammation with short-term dietary intervention is associated with a reduction of arterial stiffness in subjects with hypercholesterolaemia
Background Increased arterial stiffness has been found in patients with chronic high- grade inflammatory diseases . Whether mitigation of low- grade systemic inflammation , through a low-cholesterol/low-saturated fat diet , may have a role in improving arterial stiffness is still untested . Design We investigated whether variations in blood lipids and plasma C-reactive protein induced by low-cholesterol/low-saturated fat diet are associated with variations in large-artery stiffness in hypercholesterolemia . Methods Thirty-five patients with primary hypercholesterolemia and 15 normal control subjects were recruited for the study . Hypercholesterolaemic patients followed an 8-week low-cholesterol/low-saturated fat diet ( 30 % total fat , 5 % saturated fat , cholesterol < 200mg/daily ) . Anthropometric characteristics , blood lipids , plasma C-reactive protein and arterial stiffness were measured at baseline and after the diet . Results Arterial stiffness and C-reactive protein levels were higher in hypercholesterolaemic patients than in controls . Significant reductions in body weight ( 2 kg , 3 % ) , plasma total cholesterol ( 13.4mg/dl , 5.3 % ) , low-density lipoprotein cholesterol ( 11.2 mg/dl , 6.4 % ) , C-reactive protein ( 0.7 mg/l , 39 % ) and arterial stiffness ( from 8.9 ± 2.0 to 8.1 ± 1.9 m/s , 11 % ) were achieved among hypercholesterolaemic patients after the 8-week diet ( P < 0.05 for all ) . Bivariate correlations and multivariate analysis showed reduction in arterial stiffness after short-term diet to be associated with reduction of plasma C-reactive protein levels ( r = 0.59 , β = 0.38 , P<0.05 for both )
RESULTS Weight loss was associated with a decline in CRP level .
Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level
BACKGROUND Several studies suggest that weight loss reduces C-reactive protein ( CRP ) level ; however , the consistency and magnitude of this effect has not been well characterized .
Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level .