The vast majority of studies reported inverse associations between 25(OH)D concentration and all-cause mortality .
This association appeared to be non-linear , with progressively lower mortality with increasing 25(OH)D up to a point , beyond which there was no further decrease .
There is moderate evidence that vitamin D status is inversely associated with cancer mortality and death due to respiratory diseases , while for cardiovascular mortality , there is weak evidence of an association in observational studies , which is not supported by the data from intervention or Mendelian r and omization studies .
Epidemiological evidence suggests that vitamin D deficiency is associated with increased mortality , but it is unclear whether this is explained by reverse causation , and if there are specific causes of death for which vitamin D might be important .
Vitamin D, PTH and the risk of overall and disease-specific mortality: Results of the Longitudinal Aging Study Amsterdam
Observational studies suggest that low concentrations of serum 25-hydroxyvitamin D ( 25(OH)D ) and high concentrations of parathyroid hormone ( PTH ) are associated with a higher risk of mortality . The aim of this study was to examine whether 25(OH)D and PTH concentrations are independently associated with overall and disease-specific ( cardiovascular and cancer-related ) mortality in a large , prospect i ve population -based cohort of older adults . Data from 1317 men and women ( 65 - 85 years ) of the Longitudinal Aging Study Amsterdam were used . Cox proportional hazard analyses were used to examine whether 25(OH)D and PTH at baseline were associated with overall mortality ( with a follow-up of 18 years ) and disease-specific mortality ( with a follow-up of 13 years ) . Compared to persons in the reference category of ≥75nmol/L , persons with serum 25(OH)D < 25nmol/L ( HR 1.46 ; 95 % CI : 1.12 - 1.91 ) and 25 - 49.9nmol/L ( HR 1.24 ; 95 % CI : 1.01 - 1.53 ) had a significantly higher risk of overall mortality , as well as men with baseline PTH concentrations ≥7pmol/L ( HR 2.54 ( 95 % CI : 1.58 - 4.08 ) ) , compared to the reference category of < 2.33pmol/L. The relationship of 25(OH)D with overall mortality was partly mediated by PTH . Furthermore , men with PTH concentrations of ≥7pmol/L ( HR 3.22 ; 95 % CI : 1.40 - 7.42 ) had a higher risk of cardiovascular mortality , compared to the reference category . No significant associations of 25(OH)D or PTH with cancer-related mortality were observed . Both 25(OH)D and PTH should be considered as important health markers
The vast majority of studies reported inverse associations between 25(OH)D concentration and all-cause mortality .
This association appeared to be non-linear , with progressively lower mortality with increasing 25(OH)D up to a point , beyond which there was no further decrease .
There is moderate evidence that vitamin D status is inversely associated with cancer mortality and death due to respiratory diseases , while for cardiovascular mortality , there is weak evidence of an association in observational studies , which is not supported by the data from intervention or Mendelian r and omization studies .
Epidemiological evidence suggests that vitamin D deficiency is associated with increased mortality , but it is unclear whether this is explained by reverse causation , and if there are specific causes of death for which vitamin D might be important .