In conclusion , NVBBs , but not VBBs , determine a lower reduction in cSBP than in pSBP .
However , the difference in treatment-induced SBP amplification changes between NVBB and VBB is nearly abolished after accounting for differences in heart rate changes
β-Blockers are less effective than other antihypertensive drug classes in reducing central systolic blood pressure ( cSBP ) as compared with peripheral SBP ( pSBP ) .
Whether this effect is less pronounced with vasodilating β-blockers ( VBB ) when compared with nonvasodilating β-blockers ( NVBB ) remains unsettled .
Hemodynamic effects of amlodipine, bisoprolol, and lisinopril in hypertensive patients after liver transplantation1
Background . Hypertension is common after liver transplantation . There are few published data on optimum treatment . Augmentation index ( AIx ) is a measure of arterial wave reflection determined by pulse wave analysis . Methods . Amlodipine was administered to 24 hypertensive liver transplant recipients . Thirteen patients intolerant of or unresponsive to amlodipine  were r and omized to a crossover study comparing bisoprolol with lisinopril . Results . With amlodipine  , systolic blood pressure ( SBP ) fell from 154±2 mm Hg to 130±2 mm Hg , and AIx also fell . With bisoprolol  , SBP fell from 154±2 mm Hg to 142±4 mm Hg , but AIx increased . With lisinopril  , SBP fell from 154±2 mm Hg to 130±5 mm Hg , and AIx also fell ( P < 0.001 throughout ) . Conclusions . Amlodipine is an effective treatment for hypertension . The increased AIx with bisoprolol indicates increased wave reflection such that central aortic pressure is reduced less than peripheral SBP  . Lisinopril reduces AIx and reduces SBP more than bisoprolol and is the preferred drug
In conclusion , NVBBs , but not VBBs , determine a lower reduction in cSBP than in pSBP .
However , the difference in treatment-induced SBP amplification changes between NVBB and VBB is nearly abolished after accounting for differences in heart rate changes
β-Blockers are less effective than other antihypertensive drug classes in reducing central systolic blood pressure ( cSBP ) as compared with peripheral SBP ( pSBP ) .
Whether this effect is less pronounced with vasodilating β-blockers ( VBB ) when compared with nonvasodilating β-blockers ( NVBB ) remains unsettled .