Conclusions and implication s of key findings : Fluoxetine is associated with a significantly greater reduction in OCD severity , as measured by the CY-BOCS , NIMH-OC and CGI-S , in children and adolescents .
Additionally , it is well tolerated in children and adolescents .
The acceptability is comparable to that of the placebo-treated group .
Background : Obsessive-compulsive disorder ( OCD ) is a common psychiatric illness in children and adolescents .
Previous evidence suggests that fluoxetine is effective in the treatment of OCD in children and adolescents .
However , those studies had small sample sizes .
As a result , a systematic review , which is a more powerful method to calculate the true effect size , can be applied to examine the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Objectives : The aims of this study were to review the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Placebo-controlled trial of fluoxetine and phenelzine for obsessive-compulsive disorder.
OBJECTIVE It is now well documented that fluoxetine is a viable treatment option for patients with obsessive-compulsive disorder ( OCD ) , and there is a small body of evidence indicating that monoamine oxidase inhibitors may be effective in at least a subset of patients . The authors conducted a 10-week placebo-controlled trial of these two agents in patients who met DSM-III-R criteria for OCD . METHOD Sixty-four subjects were r and omly assigned to receive placebo , phenelzine ( 60 mg/day ) , or fluoxetine ( 80 mg/day ) . These doses were achieved by the end of week 3 of the active phase of the study . Outcomes were assessed with st and ardized instruments to measure OCD , mood , and anxiety . RESULTS Fifty-four patients completed the study . There was a significant difference among the three treatments on one OCD scale , with fluoxetine-treated patients improving significantly more than those in the placebo or phenelzine group . A subgroup of OCD patients with symmetry obsessions  did respond to phenelzine . CONCLUSIONS This study provides no evidence to support the use of phenelzine in OCD except possibly for those patients with symmetry or other atypical obsessions . There was also no support for the hypothesis that patients with high levels of anxiety would respond preferentially to phenelzine
Conclusions and implication s of key findings : Fluoxetine is associated with a significantly greater reduction in OCD severity , as measured by the CY-BOCS , NIMH-OC and CGI-S , in children and adolescents .
Additionally , it is well tolerated in children and adolescents .
The acceptability is comparable to that of the placebo-treated group .
Background : Obsessive-compulsive disorder ( OCD ) is a common psychiatric illness in children and adolescents .
Previous evidence suggests that fluoxetine is effective in the treatment of OCD in children and adolescents .
However , those studies had small sample sizes .
As a result , a systematic review , which is a more powerful method to calculate the true effect size , can be applied to examine the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Objectives : The aims of this study were to review the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .