The hypercaloric fructose feeding trials found no significant overall mean arterial blood pressure effect of fructose in comparison with other carbohydrates .
Contrary to previous concerns , we found that isocaloric substitution of fructose for other carbohydrates did not adversely affect blood pressure in humans
Concerns have been raised about the adverse effect of  fructose  on blood pressure .
International dietary guidelines , however , have not addressed fructose intake directly .
A systematic review and meta- analysis was conducted to assess the effect of fructose in isocaloric exchange for other carbohydrates on  systolic , diastolic , and mean arterial blood pressures .
Fructose ingestion acutely elevates blood pressure in healthy young humans.
Overconsumption of fructose , particularly in the form of soft drinks , is increasingly recognized as a public health concern . The acute cardiovascular responses to ingesting fructose have not , however , been well-studied in humans . In this r and omized crossover study , we compared cardiovascular autonomic regulation after ingesting water and drinks containing either glucose or fructose in 15 healthy volunteers ( aged 21 - 33 yr ) . The total volume of each drink was 500 ml , and the sugar content 60 g. For 30 min before and 2 h after each drink , we recorded beat-to-beat heart rate , arterial blood pressure , and cardiac output . Energy expenditure was determined on a minute-by-minute basis . Ingesting the fructose drink significantly increased blood pressure , heart rate , and cardiac output but not total peripheral resistance . Glucose ingestion result ed in a significantly greater increase in cardiac output than fructose but no change in blood pressure and a concomitant decrease in total peripheral resistance . Ingesting glucose and fructose , but not water , significantly increased blood pressure variability and decreased cardiovagal baroreflex sensitivity . Energy expenditure increased by a similar amount after glucose and fructose ingestion , but fructose elicited a significantly greater increase in respiratory quotient . These results show that ingestion of glucose and fructose drinks is characterized by specific hemodynamic responses . In particular , fructose ingestion elicits an increase in blood pressure that is probably mediated by an increase in cardiac output without compensatory peripheral vasodilatation
The hypercaloric fructose feeding trials found no significant overall mean arterial blood pressure effect of fructose in comparison with other carbohydrates .
Contrary to previous concerns , we found that isocaloric substitution of fructose for other carbohydrates did not adversely affect blood pressure in humans
Concerns have been raised about the adverse effect of  fructose  on blood pressure .
International dietary guidelines , however , have not addressed fructose intake directly .
A systematic review and meta- analysis was conducted to assess the effect of fructose in isocaloric exchange for other carbohydrates on  systolic , diastolic , and mean arterial blood pressures .