Results — An obesity paradox was found for cardiovascular death and all-cause death in the subgroup analyses of r and omized trial cohorts ; however , observational studies fail to show this relationship .
Conclusions — There may be an obesity paradox in atrial fibrillation patients , particularly for all-cause and cardiovascular death outcomes .
An obesity paradox was also evident for stroke/systemic embolic event outcome in NOAC trials , with a treatment effect favoring NOACs over warfarin for both efficacy and safety that was significant only for normal weight patients
Background and Purpose — Obesity is a risk factor for all-cause and cardiovascular death but , despite this , an inverse relationship between overweight or obesity and a better cardiovascular prognosis in long-term follow-up studies has been observed ; this phenomenon , described as obesity paradox , has also been found evident in atrial fibrillation cohorts .
Methods — We performed a systematic review on the relationship between body mass index and major adverse outcomes in atrial fibrillation patients .
Low Body Weight Is Associated With the Incidence of Stroke in Atrial Fibrillation Patients - Insight From the Fushimi AF Registry.
BACKGROUND Japanese patients with atrial fibrillation ( AF ) are generally small and lean , but knowledge of the clinical characteristics of those with low body weight ( LBW : ≤50 kg ) is limited . METHODS AND RESULTS The Fushimi AF Registry is a community-based prospect i ve survey of AF patients who visited the participating medical institutions in Fushmi-ku , Japan . The BW and follow-up data were available for 2,945 patients . We compared the background and the incidence of clinical events during a median follow-up of 746 days between a LBW and non-LBW group . Patients in the LBW group accounted for 26.8 % ( 788 patients ) of the total . The LBW group was more often female , older , and had higher CHADS2score . The incidence of stroke/systemic embolism ( SE ) during follow-up was higher in the LBW group ( hazard ratio ( HR ) : 2.19 , 95 % confidence interval ( CI ) : 1.57 - 3.04 ; P<0.01 ) , whereas that of major bleeding was comparable ( HR : 1.05 , 95 % CI : 0.64 - 1.68 ; P=0.84 ) . This trend was consistently observed in the subgroups stratified by age , sex , and oral anticoagulant prescription at baseline . Multivariate analysis as well as propensity-score matching analysis further supported the significance of LBW as a risk of stroke/SE . CONCLUSIONS Patients in the LBW group had high risk profiles and showed a higher incidence of stroke/SE , but the incidence of major bleeding was not particularly high
Results — An obesity paradox was found for cardiovascular death and all-cause death in the subgroup analyses of r and omized trial cohorts ; however , observational studies fail to show this relationship .
Conclusions — There may be an obesity paradox in atrial fibrillation patients , particularly for all-cause and cardiovascular death outcomes .
An obesity paradox was also evident for stroke/systemic embolic event outcome in NOAC trials , with a treatment effect favoring NOACs over warfarin for both efficacy and safety that was significant only for normal weight patients
Background and Purpose — Obesity is a risk factor for all-cause and cardiovascular death but , despite this , an inverse relationship between overweight or obesity and a better cardiovascular prognosis in long-term follow-up studies has been observed ; this phenomenon , described as obesity paradox , has also been found evident in atrial fibrillation cohorts .
Methods — We performed a systematic review on the relationship between body mass index and major adverse outcomes in atrial fibrillation patients .