Conclusions In the context of low SFAs , high-MUFA diets in isocaloric substitution for high-CHO diets did not affect blood pressure in individuals with and without hypertension .
Context Current dietary guidelines for cardiovascular disease risk management recommend restricting intake of saturated fatty acids ( SFAs ) .
However , the optimal macronutrient profile , in the context of a low-SFA diet , remains controversial .
The blood-pressure effect of replacing SFAs in diets with monounsaturated fatty acids ( MUFAs ) compared with carbohydrate has not been quantified to date .
Effects of a Diet Higher in Carbohydrate/Lower in Fat Versus Lower in Carbohydrate/Higher in Monounsaturated Fat on Postmeal Triglyceride Concentrations and Other Cardiovascular Risk Factors in Type 1 Diabetes
OBJECTIVE To compare the effects of a eucaloric diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride ( TG ) concentrations and other cardiovascular disease risk factors in nonobese subjects with type 1 diabetes and in good glycemic control . RESEARCH DESIGN AND METHODS In a parallel group design study , 30 subjects were r and omly assigned and completed one of the two eucaloric diets . Assessment s included : BMI , blood pressure , A1C , plasma lipids , and markers of oxidation , thrombosis , and inflammation . At 6 months , subjects were hospitalized for 24 h to measure plasma TG excursions . RESULTS There were no significant differences between groups other than decreased plasminogen activator inhibitor 1 ( PAI-1 ) levels and weight gain in the lower-carbohydrate/higher – monounsaturated fat group . During the 24-h testing , the lower-carbohydrate/higher – monounsaturated fat group had a lower plasma TG profile . CONCLUSIONS A diet lower in carbohydrate/higher in monounsaturated fat could offer an appropriate choice for nonobese type 1 diabetic individuals with good metabolic and weight control
Conclusions In the context of low SFAs , high-MUFA diets in isocaloric substitution for high-CHO diets did not affect blood pressure in individuals with and without hypertension .
Context Current dietary guidelines for cardiovascular disease risk management recommend restricting intake of saturated fatty acids ( SFAs ) .
However , the optimal macronutrient profile , in the context of a low-SFA diet , remains controversial .
The blood-pressure effect of replacing SFAs in diets with monounsaturated fatty acids ( MUFAs ) compared with carbohydrate has not been quantified to date .