All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .
Comprehensive geriatric assessment in elderly patients with newly diagnosed aggressive non-Hodgkin lymphoma treated with multi-agent chemotherapy.
OBJECTIVES The purpose of this prospect i ve observational study is to evaluate the relation of the comprehensive geriatric assessment ( CGA ) to tolerability and survival of multi-agent chemotherapy for curative intent in elderly patients with aggressive non-Hodgkin lymphoma ( NHL ) . MATERIAL S AND METHODS Patients who were 1 ) age ≥65 years , 2 ) newly diagnosed aggressive NHL , and 3 ) treated with multi-agent chemotherapy within 2 weeks from the time of diagnosis were enrolled from January 2011 to June 2014 . Baseline clinical , laboratory , and CGA data being composed of  Mini Nutritional Assessment -Short Form ( MNA-SF ) , Korean version of Mini Mental Status Exam , Korean-Geriatric Depression Scale , and Groningen Frailty Index ( GFI ) , were collected and analyzed for the relation to the outcome factors . RESULTS Seventy patients were included ; the median age was 73.5 years , 27 ( 38.6 % ) patients were Eastern Cooperative Oncology Group ( ECOG ) performance status ( PS ) of 2 or more , and half of the patients were high or high-intermediate risk by age-adjusted international prognostic index ( aaIPI ) . Most patients received CHOP or CHOP-like chemotherapy . Factors affecting discontinuation of chemotherapy within 12 weeks were poor MNA-SF , poor GFI , poor PS , and presence of B symptom . Among those , poor MNA-SF was independent of other variables in multivariate analysis . Poor MNA-SF , bone marrow involvement , and baseline anemia of hemoglobin<10 g /dL were found to be independent factors associated with inferior overall survival whereas aaIPI factors were not . CONCLUSION MNA-SF predicted tolerability to multi-agents chemotherapy and overall survival in elderly patients with aggressive NHL who were treated  with multi-agent chemotherapy
All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .