Hydralazine was the most common drug for others to be evaluated against .
Diazoxide , given as 75 mg bolus injections , appears to be associated with maternal hypotension requiring treatment , and ketanserin is less effective than hydralazine at reducing blood pressure .
There is no other clear evidence that any one of the other antihypertensive agents is better than another for women with severe hypertension during pregnancy .
Exceptions are diazoxide and ketanserin , which are probably not good choices
BACKGROUND Very high blood pressure during pregnancy poses a serious threat to women and their babies .
The use of drugs to lower blood pressure will reduce this risk for the women , and possibly also for the baby .
OBJECTIVES The objective of this review was to compare different antihypertensive drugs used for treatment of severe hypertension during pregnancy .
Hyperuricaemia and preeclampsia: is there a pathogenic link?
OBJECTIVE A hypothesis , based on animal studies and human observational studies , was developed proposing a direct pathogenic link between hyperuricemia and preeclampsia . Epidemiological characteristics of preeclampsia such as its uniqueness to humans and an increased incidence of preeclampsia in multiple pregnancies , increased body mass index , renal and hypertensive disease all have uric acid as their common denominator . Animal studies have linked hyperuricaemia to hypertensive , cardiovascular and renal disease . The aim of the study was to determine whether lowering the serum uric acid levels in preeclampsia would affect biochemical parameters and hypertensive control . DESIGN A r and omized , double-blind , placebo controlled study . SETTING A tertiary referral center . POPULATION Forty women with preeclampsia between 26 and 32 weeks gestation . INTERVENTION Probenecid 250 mg twice daily for seven days . MAIN OUTCOME MEASURES Renal function and haematological parameters , hypertensive control . RESULTS In the Probenecid group , there was a significant drop in the serum uric acid levels . Lower uric acid levels in the Probenecid group had no significant effect on blood pressure . Patients in the Probenecid group had a significantly lower serum creatinine value at the end of the study when compared to patients in the placebo group . Other renal function parameters ( creatinine clearance , urea , 24 h urinary protein excretion ) did not show any significant difference between the two groups . Platelet count differed between the two groups with the platelet count being significantly higher in the Probenecid group at the end of the study . CONCLUSION The significant improvement in the platelet count in the Probenecid group warrants further study
Hydralazine was the most common drug for others to be evaluated against .
Diazoxide , given as 75 mg bolus injections , appears to be associated with maternal hypotension requiring treatment , and ketanserin is less effective than hydralazine at reducing blood pressure .
There is no other clear evidence that any one of the other antihypertensive agents is better than another for women with severe hypertension during pregnancy .
Exceptions are diazoxide and ketanserin , which are probably not good choices
BACKGROUND Very high blood pressure during pregnancy poses a serious threat to women and their babies .
The use of drugs to lower blood pressure will reduce this risk for the women , and possibly also for the baby .
OBJECTIVES The objective of this review was to compare different antihypertensive drugs used for treatment of severe hypertension during pregnancy .