Some studies suggest that testosterone therapy has additional effects , which include increased bone mineral density and decreased serum high-density lipoprotein ( HDL ) cholesterol .
The clinical sequelae of oestrogen deficiency during menopause are undoubted .
However , the pathophysiological role of testosterone during the menopause is less clear .
Several r and omized , placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women .
A Comparison of Esterified Estrogens With and Without Methyltestosterone: Effects on Endometrial Histology and Serum Lipoproteins in Postmenopausal Women
Objective : To compare the efficacy and safety of esterified estrogens with and without methyltestosterone . Methods : Twenty-six women participated in a doubleblind r and omized trial for 6 months . Outcome measures included serum total and lipoprotein-bound cholesterol , vasomotor symptoms , vaginal cytology and endometrial histology , and chemistry values . Analysis of variance and t test statistics were used to assess differences . Results : After 6 months of therapy , the treatment groups were comparable with regard to symptom scores , vaginal cytology and endometrial histology scores , and clinical laboratory test values . Treatment with esterified estrogens plus methyltestosterone significantly decreased total cholesterol , high-density lipoprotein cholesterol ( HDL ) , HDL2 , HDL3 , and apolipoprotein Al compared to esterified estrogens alone . Conclusions : Esterified estrogens with or without methyltestosterone were effective at reducing menopausal symptoms and were well tolerated over 6 months of continuous treatment . A significant decrease in cholesterol and apolipoproteins in the estrogen plus methyltestosterone group suggests a potentially adverse impact on the beneficial effect normally imparted by estrogen therapy
Some studies suggest that testosterone therapy has additional effects , which include increased bone mineral density and decreased serum high-density lipoprotein ( HDL ) cholesterol .
The clinical sequelae of oestrogen deficiency during menopause are undoubted .
However , the pathophysiological role of testosterone during the menopause is less clear .
Several r and omized , placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women .