Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effects of Vitamin D Supplementation on C-peptide and 25-hydroxyvitamin D Concentrations at 3 and 6 Months
The link between African-Americans ’ disproportionate rates of diabetes , obesity and vitamin D deficiency may be marked by C-peptide as an indicator of insulin secretion . We hypothesize that vitamin D supplementation will increase C-peptide , a marker of insulin secretion . During 3 winters from 2007 - 2010 , 328 healthy African-Americans ( median age , 51 years ) living in Boston , MA were r and omized into a 4-arm , double-blind trial for 3 months of placebo , 1000 , 2000 , or 4000 IU of vitamin D3 . The differences in non-fasting C-peptide between baseline and 3 months were −0.44 ng/mL for those receiving placebo , −0.10 ng/mL for those receiving 1000 IU/d , 0 ng/mL for those receiving 2000 IU/d , 1.24 ng/mL for those receiving 4000 IU/d ( C-peptide increased 0.42 ng/mL for each additional 1000 IU/d of vitamin D3 , p < 0.001 ) . Vitamin D supplementation  increased C-peptide in overweight African-Americans and may be compatible with other recommendations for diabetes prevention and management including weight loss and increased physical activity
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .