Subgroup analysis revealed that increasing dietary ALA tends to elevate CRP concentration  in healthy subjects .
However , the null effect of ALA supplementation on other inflammatory markers was not changed in various subgroups , indicating that the results are stable .
Meta-regression results revealed a negative relationship between the effect size on CRP and its baseline concentration .
No significant publication bias was observed for all inflammatory markers as suggested by funnel plot and Begg ’s test .
Conclusion Our meta- analysis did not find any beneficial effect of ALA supplementation  on reducing inflammatory markers including TNF , IL-6 , CRP , sICAM-1 , and sVCAM-1 .
However , in healthy subjects  , ALA supplementation might increase CRP concentration
Purpose The aim of the current meta- analysis was to investigate the effect of increasing dietary ALA intake on the blood concentration of inflammatory markers including tumor necrosis factor ( TNF ) , interleukin 6 ( IL-6 ) , C-reactive protein ( CRP ) , soluble intercellular adhesion molecule-1 ( sICAM-1 ) , and soluble vascular cell adhesion molecule-1 ( sVCAM-1 )  in adults .
Associations of erythrocyte membrane fatty acids with the concentrations of C-reactive protein, interleukin 1 receptor antagonist and adiponectin in 1373 men.
Dietary and endogenous fatty acids could play a role in low- grade inflammation . In this cross-sectional study the proportions of erythrocyte membrane fatty acids ( EMFA ) and the concentrations of C-reactive protein ( CRP ) , interleukin-1 receptor antagonist ( IL-1Ra ) and adiponectin were measured and their confounder-adjusted associations examined in 1373 r and omly selected Finnish men aged 45 - 70 years participating in the population based Metsim study in Eastern Finl and . The sum of n-6 EMFAs , without linoleic acid ( LA ) , was positively associated with concentrations of CRP and IL-1Ra ( r partial=0.139 and r partial=0.115 , P<0.001 ) . These associations were especially strong among lean men ( waist circumference < 94 cm ; r partial=0.156 and r partial=0.189 , P<0.001 ) . Total n-3 EMFAs correlated inversely with concentrations of CRP ( r partial=-0.098 , P<0.001 ) . Palmitoleic acid ( 16:1n-7 ) correlated positively with CRP ( r partial=0.096 , P<0.001 ) . Cis-vaccenic acid ( 18:1n-7 ) was associated with high concentrations of adiponectin ( r partial=0.139 , P<0.001 ) . In conclusion , n-6 EMFAs , except for LA , correlated positively with the inflammatory markers . Palmitoleic acid was associated with CRP , whereas , interestingly , its elongation product , cis-vaccenic acid , associated with anti-inflammatory adiponectin
Subgroup analysis revealed that increasing dietary ALA tends to elevate CRP concentration  in healthy subjects .
However , the null effect of ALA supplementation on other inflammatory markers was not changed in various subgroups , indicating that the results are stable .
Meta-regression results revealed a negative relationship between the effect size on CRP and its baseline concentration .
No significant publication bias was observed for all inflammatory markers as suggested by funnel plot and Begg ’s test .
Conclusion Our meta- analysis did not find any beneficial effect of ALA supplementation  on reducing inflammatory markers including TNF , IL-6 , CRP , sICAM-1 , and sVCAM-1 .
However , in healthy subjects  , ALA supplementation might increase CRP concentration
Purpose The aim of the current meta- analysis was to investigate the effect of increasing dietary ALA intake on the blood concentration of inflammatory markers including tumor necrosis factor ( TNF ) , interleukin 6 ( IL-6 ) , C-reactive protein ( CRP ) , soluble intercellular adhesion molecule-1 ( sICAM-1 ) , and soluble vascular cell adhesion molecule-1 ( sVCAM-1 )  in adults .