Conclusions : Isoflavone treatments exert a moderately beneficial effect against  estrogen-deficient bone loss in women .
The effect appears dependent on whether isoflavone treatments are in aglycone form ; we conclude that beneficial effects against bone loss may be enhanced for isoflavone aglycones
Background : Age-related estrogen deficiency leads to accelerated bone resorption .
There is evidence that , through selective estrogen receptor modulation , isoflavones may exert beneficial effects against  estrogen-deficient bone loss .
Isoflavone aglycones show higher bioavailability than their glycosidic counterparts and thus may have greater potency .
Objective : To summarize evidence , we executed a systematic review and meta- analysis examining isoflavone therapies and bone mineral density ( BMD ) loss in peri- and postmenopausal women .
Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial.
CONTEXT Postmenopausal estrogen therapy has been posited to have some beneficial effects on aging processes , but its use has risks . Isoflavones , estrogenlike compounds naturally occurring in plant foods , might confer positive effects with fewer adverse effects . OBJECTIVE To investigate whether soy protein with isoflavones improves cognitive function , bone mineral density , and plasma lipids in postmenopausal women . DESIGN , SETTING , AND PARTICIPANTS Double-blind , r and omized , placebo-controlled trial of 202 healthy postmenopausal women aged 60 to 75 years , recruited from a population -based sample in the Netherl and s , conducted between April 2000 and September 2001 . INTERVENTION Participants were r and omly assigned to receive 25.6 g of soy protein containing 99 mg of isoflavones ( 52 mg genistein , 41 mg daidzein , and 6 mg glycetein or total milk protein as a powder on a daily basis for 12 months . MAIN OUTCOME MEASURES Cognitive function was assessed using the following instruments : dementia , Mini-Mental State Examination ; memory , Rey Auditory Verbal Learning Test , immediate recall , delayed recall , and recognition , the Digit Span forward and reversed , and the Doors test ; complex attention tasks , Digit Symbol Substitution and Trailmaking , A1 , A2 , and B ; and verbal skills , Verbal Fluency A and N , animals and occupations , and the Boston Naming Task . Bone mineral density of the hip and lumbar spine was assessed using dual-energy x-ray absorptiometry scanning . Lipid assessment included lipoprotein(a ) , total cholesterol , low-density lipoprotein , high-density lipoprotein , and triglycerides . RESULTS A total of 175 women completed the baseline and at least 1 postintervention analysis and were included in the modified intent-to-treat analysis . Adherence was good ( median plasma genistein levels , 17.2 and 615.1 nmol/L for placebo and soy group , respectively ) . Cognitive function , bone mineral density , or plasma lipids did not differ significantly between the groups after a year . CONCLUSION This double-blind r and omized trial does not support the hypothesis that the use of soy protein supplement containing isoflavones improves cognitive function , bone mineral density , or plasma lipids in healthy postmenopausal women when started at the age of 60 years or later
Conclusions : Isoflavone treatments exert a moderately beneficial effect against  estrogen-deficient bone loss in women .
The effect appears dependent on whether isoflavone treatments are in aglycone form ; we conclude that beneficial effects against bone loss may be enhanced for isoflavone aglycones
Background : Age-related estrogen deficiency leads to accelerated bone resorption .
There is evidence that , through selective estrogen receptor modulation , isoflavones may exert beneficial effects against  estrogen-deficient bone loss .
Isoflavone aglycones show higher bioavailability than their glycosidic counterparts and thus may have greater potency .
Objective : To summarize evidence , we executed a systematic review and meta- analysis examining isoflavone therapies and bone mineral density ( BMD ) loss in peri- and postmenopausal women .