In meta-regression , changes in plasma concentrations of adiponectin , leptin and CRP were associated with duration of treatment , but not with either change in BMI or baseline BMI values .
CONCLUSION Orlistat is effective in increasing plasma concentrations of adiponectin and decreasing those of leptin and CRP
AIMS To conduct a systematic review and meta- analysis of relevant r and omized clinical trials ( RCTs ) to ascertain the effect size of orlistat in modulating plasma levels of adipokines , ghrelin and C-reactive protein ( CRP ) .
Rise of plasma ghrelin with weight loss is not sustained during weight maintenance.
OBJECTIVE Ghrelin is postulated to be an orexigenic signal that promotes weight regain after weight loss ( WL ) . However , it is not known whether this putative effect of ghrelin is sustained after weight stabilization . The objective of this study was to investigate the relationship of plasma ghrelin concentrations to active WL and weight maintenance in obese subjects . RESEARCH METHODS AND PROCEDURES This study was a r and omized clinical trial , with a 12-month follow-up period . Obese Mexican-American women matched for age and BMI were r and omized to a 12-month WL program ( n = 25 ) or no intervention ( controls , n = 23 ) . Interventions included diet , exercise , and orlistat .  Body weight and fasting ghrelin , leptin , insulin , and glucose concentrations were measured at baseline and 6 and 12 months . RESULTS The WL group lost 8.5 % of body weight after 6 months and maintained the new weight for the next 6 months . Ghrelin concentrations increased significantly at 6 months but returned to baseline at 12 months . Baseline ghrelin concentrations were directly related to the degree of WL achieved after 12 months . Controls experienced no change in BMI or ghrelin levels . There were no associations between plasma ghrelin and leptin or insulin concentrations . DISCUSSION Consistent with previous results , ghrelin rises in response to WL , perhaps as a counterregulatory mechanism . However , the present results indicate that ghrelin concentrations return to baseline with sustained weight maintenance , suggesting that its effects are unlikely to regulate long-term energy balance . Baseline ghrelin concentrations are related to the degree of WL that can be achieved by active weight reduction
In meta-regression , changes in plasma concentrations of adiponectin , leptin and CRP were associated with duration of treatment , but not with either change in BMI or baseline BMI values .
CONCLUSION Orlistat is effective in increasing plasma concentrations of adiponectin and decreasing those of leptin and CRP
AIMS To conduct a systematic review and meta- analysis of relevant r and omized clinical trials ( RCTs ) to ascertain the effect size of orlistat in modulating plasma levels of adipokines , ghrelin and C-reactive protein ( CRP ) .