Outcomes , such as range of motion , recurrence , and clinical success , were frequently defined , however many different definitions were used .
This systematic review summarizes the outcome reporting st and ards in Dupuytren ’s disease treatment research .
New insights into the immediate outcome of collagenase injections for Dupuytren’s contracture
Collagenase clostridium histolyticum is now established as an effective and safe option to treat patients with a single joint affected with Dupuytren ’s contracture . We have extended its use to  natatory and combined cords .  In a prospect i ve consecutive series of 298 cords in 237 patients , the mean total extension loss improved in cords crossing the metacarpophalangeal joint from 46 ° to 1 ° , in cords crossing the proximal interphalangeal joint from 56 ° to 7 ° , in natatory cords from 130 ° to 25 ° and in combined cords from 102 ° to 16 ° . The immediate correction of combined cords and natatory cords was less reliable than that obtained in cords crossing the metacarpophalangeal joint or proximal interphalangeal joint . Less severe pre-intervention contractures tended to correct better . We found a high complication rate , which may cause alarm . A total of 21 % developed skin splits , with the risk of skin splits generally increasing with more severe pre-injection deformity . Blood blisters were only encountered after manipulation of the more severe contractures . A total of 23 patients ( 8 % ) had a spontaneous rupture and 57 patients ( 19 % ) had a partial spontaneous rupture . Only 4.9 % needed a second injection . We noticed a learning curve , with seven of the first 20 cords ( 35 % ) needing a second injection to achieve a satisfactory correction and then only seven ( 2.5 % ) in the rest . Level of evidence :
Outcomes , such as range of motion , recurrence , and clinical success , were frequently defined , however many different definitions were used .
This systematic review summarizes the outcome reporting st and ards in Dupuytren ’s disease treatment research .