Our review revealed a great heterogeneity in definition , format , and values of what is considered a clinical ly relevant difference in pain in RCTs of analgesics , and st and ardizations are advisable
OBJECTIVE To describe the  pain decrease considered as clinical ly relevant when design ing a trial and reporting its results .
A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster
This r and omized , double-blind , placebo-controlled crossover study measured the effect of a single dose of oral gabapentin ( 900 mg ) on pain and allodynia associated with herpes zoster . Pain severity decreased by 66 % with gabapentin compared to 33 % with placebo . Reductions in allodynia area and severity , and overall pain relief , were also greater with gabapentin
Our review revealed a great heterogeneity in definition , format , and values of what is considered a clinical ly relevant difference in pain in RCTs of analgesics , and st and ardizations are advisable
OBJECTIVE To describe the  pain decrease considered as clinical ly relevant when design ing a trial and reporting its results .