No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .
Effect of L-carnitine on the size of low-density lipoprotein particles in type 2 diabetes mellitus patients treated with simvastatin.
Therapeutic modulation of low-density lipoprotein ( LDL ) size could be of benefit in reducing the risk of cardiovascular events in diabetic patients . This study evaluated the efficacy of L-carnitine on the size of LDL particles in type 2 diabetes mellitus patients treated with simvastatin . Eighty diabetic patients were r and omly assigned to 1 of 2 treatment groups for 3 months . The 2 groups received either simvastatin monotherapy 20 mg ( n = 40 ) or L-carnitine 2 g/d and simvastatin 20 mg ( n = 40 ) . The following variables were assessed at baseline ; after washout ; and at 1 , 2 , and 3 months of treatment : body mass index , fasting plasma glucose , glycosylated hemoglobin , total cholesterol , LDL cholesterol , LDL subclasses , LDL size , high-density lipoprotein cholesterol , triglycerides , apolipoprotein A-1 , and apolipoprotein B-100 . After 12 weeks , comparing the 2 groups , we observed a decrease in fasting plasma glucose ( 1.45 vs 0.61 mmol/L , P < .001 ) and an increase in glycosylated hemoglobin ( 0.2 % vs 0.4 % , P < .05 ) . Moreover , there was a decrease in total cholesterol ( 2.07 vs 1.45 mmol/L , P < .001 ) , LDL ( 1.65 vs 1.29 mmol/L , P < .001 ) , triglycerides ( 1.36 vs 0.41 mmol/L , P < .001 ) , apo B-100 ( 49 vs 9 g/L , P < .001 ) , and small-sized LDL proportion ( 10.8 % vs 4.9 % , P < .001 ) , whereas LDL particle size increased ( 6 vs 3 A , P < .001 ) and HDL increased ( 0.2 vs 0.11 mmol/L , P < .001 ) . We observed that patients treated with carnitine and simvastatin showed a reduction in small-sized LDL proportion and an increase in LDL particle size
No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .