We found that female sex , direct inguinal hernias at the primary procedure , operation for a recurrent inguinal hernia , and smoking were significant risk factors for recurrence after inguinal hernia surgery .
Background .
Several factors influence the risk of recurrence after inguinal hernia surgery ; however , a systematic review and meta- analysis of patient-related risk factors for recurrence after inguinal hernia surgery has not been performed earlier .
Serum MMP 2 and TIMP 2 in patients with inguinal hernias.
BACKGROUND More than sixty thous and inguinal hernia operations are performed every year in Pol and . Despite many years of related research , the exact pathologic mechanism of this condition is still not fully understood . Recent studies suggested a pronounced relationship between the molecular structure of collagen fibers and the activity of metalloproteinases , the enzymes taking part in the degradation of collagen , as well as their tissue inhibitors . MATERIAL S AND METHODS A prospect i ve study has been established to measure serum levels of the matrix metalloproteinase 2 ( MMP-2 ) and Matrix metalloproteinase tissue inhibitor 2 ( TIMP-2 ) in 150 males between the ages of 26 and 70 . The control group ( CG ) consisted of thirty healthy male volunteers of a similar age distribution . RESULTS Our results indicate that MMP-2 was highest in the direct hernia group , a statistically very significant elevation ( P<0 ( . ) 05 ) of 1562ng mL(-1 ) against the CG 684ng mL(-1 ) . The highest level of TIMP , 78ng mL(-1 ) , was found in the group with recurrent hernia , against 49 ( . ) 5ng mL(-1 ) of the CG ( statistical significance of P<0 ( . ) 05 ) . DISCUSSION The MMP-2 and TIMP-2 levels were concurrently elevated only in the recurrent hernia group . CONCLUSIONS The patients with inguinal hernia have a statistically significant increase in serum levels of MMP-2 . Our finding of the MMP-2 and TIMP-2 distinctly higher in the patients suffering from recurrence of direct inguinal hernia ( reflecting a previous surgical failure ) may suggest the theory that the extracellular matrix defect lies at the basis of this disorder
We found that female sex , direct inguinal hernias at the primary procedure , operation for a recurrent inguinal hernia , and smoking were significant risk factors for recurrence after inguinal hernia surgery .
Background .
Several factors influence the risk of recurrence after inguinal hernia surgery ; however , a systematic review and meta- analysis of patient-related risk factors for recurrence after inguinal hernia surgery has not been performed earlier .