Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .
The Effect of Prophylactic Antibiotics on Post Laparoscopic Cholecystectomy Infectious Complications: A Double-Blinded Clinical Trial
Background Laparoscopic cholecystectomy ( LC ) is one of the most common surgeries in laparoscopic surgery . Although , it is believed that LC has low-risk for post-operative infectious complications , the use of a prophylactic antibiotic is still controversial in elective LC . Objective To determine the impact of prophylactic antibiotics on postoperative infection complications in elective laparoscopic cholecystectomy . Methods In this double-blind , placebo-controlled , r and omized , clinical trial , patients who were c and i date s for elective LC , from March 2012 to 2015 , in four hospitals in Babol , Iran , were studied . Patients were allocated r and omly to two groups , i.e. , group C : Cefazolin ( n = 182 ) and group P : placebo ( n = 247 ) . Group C received 1 g of Cefazolin 30 minutes before anesthesia and and then , six and 12 hours after anesthesia . Group P patients received 10 ml of isotonic sodium chloride solution . Age , gender , type of gallbladder diseases ( stone , polyp , or hydrops ) , the length of post-operative hospitalization , frequency of gallbladder rupture , the duration of surgery , and the kinds of complications associated with infections were collected for each patient in the two groups . The data were analyzed by IBM-SPSS version 20 , using the t-test and the chi-squared test , and a p-value < 0.05 was considered as significant . Results There were no significant differences between the two groups in terms of gender ( C versus P : 18 ( 9.9 % ) male versus 22 ( 9 % ) ; p = 0.74 ) , age ( C versus P : 43.75 + 13.30 years versus 40.91 + 13.05 ; p = 0.20 ) , and duration of surgery ( C versus P : 34.97 ± 8.25 min versus 34.11 ± 8.39 ; p = 0.71 ) . There were no significant differences between the two groups in the incidences of post-operative infection ( C versus P : 3 ( 1.7 % ) versus 5 ( 2 % ) ; p = 0.99 ) and rupture of the gallbladder ( C versus P : 14 ( 7.8 % ) versus 17 ( 6.8 % ) ; p = 0.85 ) . No other post-operative systemic infectious complications ( e.g. , sepsis , pneumonia , or urinary tract infection ) were found in either group . Conclusion For patients who underwent laparoscopic cholecystectomy ( LC ) , prophylactic antibiotics had no important role in the prevention of infections ; so these antibiotics apparently are not necessary in treatment , and they are not recommended for patients with laparoscopic cholecystectomy as low-risk selective antibiotics . Trial registration The trial was registered at the Iranian Clinical Trial Registry ( http://www.i rct .ir ) with the I RCT identification number I RCT 2013070413865N1 . Funding This research was supported financially by the Research Council of Babol University of Medical Sciences
Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .