Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .
Research: Treatment A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes
Aims In the UK , lifestyle intervention is first-line management in Type 2 diabetes . It is unclear what type of diet is most efficacious for improving glycaemic control . This study investigated the effects of an oat-enriched diet on glycaemic control , postpr and ial glycaemia , inflammation and oxidative stress compared with st and ard dietary advice . Methods In a r and omized crossover design , 27 volunteers with Type 2 diabetes , managed on diet and lifestyle only , were observed for two consecutive 8-week periods following either the oat-enriched diet or re-enforced st and ard dietary advice . Volunteers attended at baseline ( habitual intake ) and 8 and 16 weeks . Measurements included basic clinical measurements and fasted and postpr and ial ( 3-h ) glucose and insulin in response to a healthy test meal . Markers of inflammation and oxidative stress , including high-sensitivity C-reactive protein , interleukin 6 , interleukin 18 , tumour necrosis factor-alpha , adiponectin , thiobarbituric acid reactive substances , oxygen radical antioxidant capacity , oxidized LDL and urinary isoprostanes , were also measured at fasting and in the postpr and ial period . Results There were no diet-related effects on glycaemic control or glycaemic or insulinaemic responses to the test meal . Total cholesterol ( 5.1 ± 1.0 vs. 4.9 ± 0.8 mmol/l , P = 0.019 ) concentrations declined following the oat-enriched diet compared with st and ard dietary advice . There was a postpr and ial decline in adiponectin concentration ( P = 0.009 ) , but no effect of dietary intervention . None of the measures of oxidative stress or inflammation were altered by the oat-enriched diet compared with st and ard dietary advice . Conclusion The oat-enriched diet had a modest impact on lipid lowering , but did not impact on oxidative stress or inflammation in these volunteers with Type 2 diabetes
Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .