Subgroup analysis suggested the existence of liver disease at baseline , synbiotics supplementation and duration of supplementation ≥ 8 weeks result ed in more pronounced improvement in liver function enzymes than their counterparts .
Conclusions Probiotics and synbiotics may be suggested as supplements to improve serum concentration of liver enzymes , especially when synbiotics administered for a period ≥ 8 weeks and in individuals with liver disease
Purpose The gut – liver interaction suggests that modification of gut bacterial flora using probiotics and synbiotics may improve liver function .
This systematic review and meta- analysis aim ed to clarify the effect of probiotics and synbiotics consumption on the serum concentration of liver function enzymes .
Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study
Background Bacillus probiotics health benefits have been until now quite poorly studied in the elderly population . This study aim ed to assess the effects of Bacillus subtilis CU1 consumption on immune stimulation and resistance to common infectious disease ( CID ) episodes in healthy free-living seniors . Results One hundred subjects aged 60–74 were included in this r and omized , double-blind , placebo-controlled , parallel-arms study . Subjects consumed either the placebo or the probiotic ( 2.109B . subtilis CU1 spores daily ) by short periodical courses of 10 days intermittently , alternating 18-day course of break . This scheme was repeated 4 times during the study . Symptoms of gastrointestinal and upper/lower respiratory tract infections were recorded daily by the subjects throughout the study ( 4 months ) . Blood , saliva and stool sample s were collected in a predefined subset of the first forty-four subjects enrolled in the study .  B. subtilis CU1 supplementation did not statistically significantly decrease the mean number of days of reported CID symptoms over the 4-month of study ( probiotic group : 5.1 ( 7.0 ) d , placebo group : 6.6 ( 7.3 ) d , P = 0.2015 ) . However , in the subset of forty-four r and omized subjects providing biological sample s , we showed that consumption of B. subtilis CU1 significantly increased fecal and salivary secretory IgA concentrations compared to the placebo . A post-hoc analysis on this subset showed a decreased frequency of respiratory infections in the probiotc group compared to the placebo group . Conclusion Taken together , our study provides evidence that B. subtilis CU1 supplementation during the winter period may be a safe effective way to stimulate immune responses in elderly subjects
Subgroup analysis suggested the existence of liver disease at baseline , synbiotics supplementation and duration of supplementation ≥ 8 weeks result ed in more pronounced improvement in liver function enzymes than their counterparts .
Conclusions Probiotics and synbiotics may be suggested as supplements to improve serum concentration of liver enzymes , especially when synbiotics administered for a period ≥ 8 weeks and in individuals with liver disease
Purpose The gut – liver interaction suggests that modification of gut bacterial flora using probiotics and synbiotics may improve liver function .
This systematic review and meta- analysis aim ed to clarify the effect of probiotics and synbiotics consumption on the serum concentration of liver function enzymes .