SAMe was not different from placebo and established antidepressants .
The exception was that compared to imipramine , fewer participants experienced troublesome adverse effects when treated with parenteral SAMe .
BACKGROUND Depression is a recurrent illness with high rates of chronicity , treatment-resistance and significant economic impact .
There is evidence in the literature that S-adenosyl methionine ( SAMe ) , a naturally occurring compound in the human body , has antidepressant efficacy .
This product may be an important addition to the armamentarium of antidepressant agents .
OBJECTIVES To assess the effects of SAMe in comparison with placebo or antidepressants for the treatment of depression in adults .
S‐adenosylmethionine blood levels in major depression: changes with drug treatment
Introduction ‐ The relationship between plasma levels of S‐adenosylmethionine ( SAMe ) , an endogenous methyl donor , and clinical response were studied in patients with a DSM‐III‐R diagnosis of major depression . Material and methods ‐ A double‐blind r and omized protocol comparingoral SAMe with oral desipramine , involving a total of 26 patients , was employed . Results ‐At the end of the 4‐week trial , 62 % of the patients treated with SAMe and 50 % of the patients treated with desipramine had significantly improved . Regardless of the type of treatment , patients witha 50 % decrease in their Hamilton Depression Scale ( HAM‐D ) score showed a significant increase in plasma SAMe concentration . Conclusion ‐ The significant correlation between plasma SAMe levels and the degree of clinical improvement in depressed patients regardless of the type of treatment suggests that SAMe may play an important role in regulating mood
SAMe was not different from placebo and established antidepressants .
The exception was that compared to imipramine , fewer participants experienced troublesome adverse effects when treated with parenteral SAMe .
BACKGROUND Depression is a recurrent illness with high rates of chronicity , treatment-resistance and significant economic impact .
There is evidence in the literature that S-adenosyl methionine ( SAMe ) , a naturally occurring compound in the human body , has antidepressant efficacy .
This product may be an important addition to the armamentarium of antidepressant agents .
OBJECTIVES To assess the effects of SAMe in comparison with placebo or antidepressants for the treatment of depression in adults .