No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .
Minocycline controls clinical outcomes and inflammatory cytokines in moderate and severe meibomian gland dysfunction.
PURPOSE To assess clinical outcomes and tear cytokine levels in patients with moderate and severe meibomian gl and dysfunction ( MGD ) after treatment with oral minocycline and artificial tears versus artificial tears only . DESIGN Prospect i ve , r and omized clinical trial . METHODS Sixty eyes of 60 patients with stage 3 or 4 meibomian gl and dysfunction were enrolled . We evaluated the tear film break-up time , Schirmer test results , corneal and conjunctival fluorescein staining results , biomicroscopic examination results of lid margins and meibomian gl and s , and tear cytokine levels before and after 1 month and 2 months of oral minocycline and artificial tears ( group 1 ) or artificial tears only ( group 2 ) . Tear sample s were collected and analyzed using a BD Cytometric Bead Array ( BD Bioscience , San Jose , California , USA ) for detection of interleukin (IL)-1β , IL-6 , IL-7 , IL-8 , IL-12p70 , IL-17α , interferon-γ , tumor necrosis factor-α , and monocyte chemotactic protein-1 . The Wilcoxon signed-rank test , Mann-Whitney U test , generalized linear model , and linear mixed model were performed . RESULTS Patients in group 1 showed statistically significant improvement in all clinical signs and symptoms after 1 month and 2 months of treatment . Patients of group 1 showed more significant improvement compared with those in group 2 . Patients in group 1 also showed statistically significant reductions in IL-6 , IL-1β , IL-17α , tumor necrosis factor-α , and IL-12p70 after 2 months of treatment . CONCLUSIONS Oral minocycline can provide clinical benefits in treating moderate and severe meibomian gl and dysfunction by reducing inflammatory cytokine levels
No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .