For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .
Sildenafil citrate for the treatment of erectile dysfunction in men with Type II diabetes mellitus
Abstract . Aims /hypothesis : Ninety percent of all men with diabetes have Type II ( non-insulin-dependent ) diabetes mellitus , and erectile dysfunction ( ED ) is common in this patient group . This study evaluated the effects of sildenafil on men with erectile dysfunction and Type II diabetes and compared the results with glycated haemoglobin concentrations and chronic diabetic complications . Methods : Patients ( mean age , 59 years ) in this double-blind , placebo-controlled trial were r and omised to sildenafil ( 25–100 mg ; n = 110 ) or matching placebo ( n = 109 ) for 12 weeks . Primary criteria for efficacy included questions 3 ( achieving an erection ) and 4 ( maintaining an erection ) from the International Index of Erectile Function ( IIEF , score range , 0–5 ) . Secondary outcome measures included a global efficacy question ( GEQ ) , patient event logs , a life satisfaction checklist , and the remaining IIEF questions . Results : After 12 weeks , the mean scores for questions 3 and 4 had improved significantly in patients receiving sildenafil ( 3.42 ± 0.23 and 3.35 ± 0.24 ) compared with placebo ( 1.86 ± 0.22 and 1.84 ± 0.23 ; p < 0.0001 ) . Similarly , the GEQ score was higher in the sildenafil ( 64.6 % ) than the placebo group ( 10.5 % ) . Even when correlating efficacy with glycated haemoglobin concentrations ( ≤ 8.3 % or > 8.3 % , the median concentration found in this study ) or the number of diabetic complications ( 0 or ≥ 1 ) , the mean scores for the GEQ and questions 3 and 4 from the IIEF remained higher for all the sildenafil groups compared with the placebo groups ( p < 0.0001 ) . Conclusion /interpretation : Sildenafil was well-tolerated and effective in improving  erectile dysfunction in men with Type II diabetes , even in patients with poor glycaemic control and chronic complications . [ Diabetologia ( 2001 ) 44 : 1296–1301
For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .