Probiotics intake in patients with MetS result ed in improvements in body mass index , blood pressure , glucose metabolism , and lipid profile in some studies .
Regarding inflammatory biomarkers , probiotics also positively affected the soluble vascular cell adhesion molecule 1 ( sVCAM-1 ) , interleukine-6 ( IL-6 ) , tumor necrosis factor α ( TNF-α ) , vascular endothelial growth factor ( VEGF ) , and thrombomodulin .
Despite the diversity of the published studies , the intake of probiotics for patients with MetS may offer a discrete improvement in some of the clinical characteristics of the MetS and a decrease in inflammatory biomarkers .
The aim of this systematic review is to evaluate whether the use of probiotics has any effect on the components of metabolic syndrome ( MetS ) before patients develop type 2 diabetes .
Multispecies Probiotic Supplementation Favorably Affects Vascular Function and Reduces Arterial Stiffness in Obese Postmenopausal Women—A 12-Week Placebo-Controlled and Randomized Clinical Study
Obesity in the postmenopausal period is associated with an increased risk of cardiovascular diseases in women . One of the key drivers of cardiovascular risk is endothelial dysfunction ; thus , this is also a crucial point for studies on new therapeutic methods of cardioprotective properties . The aim of the current study was to evaluate the effect of two doses of multispecies probiotic Ecologic ® Barrier supplement on functional ( primary endpoint ) and biochemical parameters ( secondary endpoint ) of endothelial dysfunction in obese postmenopausal women in a 12-week r and omized , placebo-controlled clinical trial . A total of 81 obese Caucasian women participated in the trial . The subjects were r and omly assigned to three groups that received a placebo , a low dose ( LD ) ( 2.5 × 109 colony forming units ( CFU ) per day ) , or a high dose ( HD ) ( 1 × 1010 CFU per day ) of lyophilisate powder containing live multispecies probiotic bacteria . The probiotic supplement was administered each day for 12 weeks in two equal portions . A high dose probiotic supplementation for 12 weeks decreased systolic blood pressure , vascular endothelial growth factor , pulse wave analysis systolic pressure , pulse wave analysis pulse pressure , pulse wave analysis augmentation index , pulse wave velocity , interleukin-6 , tumor necrosis factor alpha , and thrombomodulin . Low doses of probiotic supplementation decreased the systolic blood pressure and interleukin-6 levels . The mean changes in the estimated parameters , compared among the three groups , revealed significant differences in the vascular endothelial growth factor , the pulse wave analysis systolic pressure , the pulse wave analysis augmentation index , the pulse wave velocity , the tumor necrosis factor alpha , and thrombomodulin . The post hoc tests showed significant differences for all parameters between HD and the placebo group , and HD and LD ( besides pulse wave analysis augmentation index ) . We show for the first time that supplementation with multispecies probiotic Ecologic ® Barrier favorably modifies both functional and biochemical markers of vascular dysfunction in obese postmenopausal women
Probiotics intake in patients with MetS result ed in improvements in body mass index , blood pressure , glucose metabolism , and lipid profile in some studies .
Regarding inflammatory biomarkers , probiotics also positively affected the soluble vascular cell adhesion molecule 1 ( sVCAM-1 ) , interleukine-6 ( IL-6 ) , tumor necrosis factor α ( TNF-α ) , vascular endothelial growth factor ( VEGF ) , and thrombomodulin .
Despite the diversity of the published studies , the intake of probiotics for patients with MetS may offer a discrete improvement in some of the clinical characteristics of the MetS and a decrease in inflammatory biomarkers .
The aim of this systematic review is to evaluate whether the use of probiotics has any effect on the components of metabolic syndrome ( MetS ) before patients develop type 2 diabetes .