In conclusion , we observed no improvement in muscle strength after the administration of vitamin D with or without calcium supplements .
We did find a small but significant deterioration of mobility .
BACKGROUND It has been suggested that vitamin D status or supplementation is important for maintaining or improving muscle strength and mobility in older adults .
The study results , however , do not provide consistent results .
We therefore aim ed to summarise the available evidence systematic ally , including only studies conducted in community-dwelling older persons .
Combination of alfacalcidol with calcium can improve quadriceps muscle strength in elderly ambulatory Thai women who have hypovitaminosis D: a randomized controlled trial.
OBJECTIVE The purpose of this study was to evaluate the efficacy of alfacalcidol and calcium on the improvement of muscle strength in ambulatory elderly Thai women in age group of 65 or more who have hypovitaminosis D. MATERIAL AND METHOD Seventy-two postmenopausal women age 65 years or more were enrolled to this study . Blood was collected from all participants for measured of 25(OH)D3 , intact PTH and vitamin D receptor ( VDR ) genotypes . After blood collection , the quadriceps muscle strength was measured using the isokinetic dynamometer device . There were 42 subjects who satisfy the eligible criteria and agreed to participate in the experimental r and omized controlled study . These subjects were r and omized into two groups , one received calcium 1500 g/day combined with alfacalcidol 0.5 mg/day . Another group received calcium 1500 g/day with placebo . RESULTS After 12 weeks of intervention , 40 subjects had the second muscle strength measurement ( 2 dropped out ) . By ANCOVA analysis , there were significant improvement of muscle strength in the group that received alfacalcidol compared to placebo in both 30 degrees/sec ( 20.28 vs.16.29 , p = 0.025 ) and 60 degrees/sec ( 20.32 vs. 15.05 , p = 0.002 ) angular velocities . CONCLUSION Daily doses of 0.5 mg alfacalcidol with calcium effectively improved muscle strength in elderly Thai women who had low level of 25(OH)D3 compared to calcium alone
In conclusion , we observed no improvement in muscle strength after the administration of vitamin D with or without calcium supplements .
We did find a small but significant deterioration of mobility .
BACKGROUND It has been suggested that vitamin D status or supplementation is important for maintaining or improving muscle strength and mobility in older adults .
The study results , however , do not provide consistent results .
We therefore aim ed to summarise the available evidence systematic ally , including only studies conducted in community-dwelling older persons .