Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Vitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status
Purpose The Nutrition Societies in Germany , Austria , and Switzerl and recommend a daily intake of 20 µg vitamin D3 for adults when endogenous synthesis is absent . The current study aim ed to eluci date whether this vitamin D3 dose impacts cardiovascular risk markers of adults during the winter months . Methods The study was conducted in Halle ( Saale ) , Germany ( 51o northern latitude ) as a placebo-controlled , double-blinded , r and omised trial ( from January to April ) . A total of 105 apparently healthy subjects ( male and female , 20–71 years old ) were included . Subjects were r and omly allocated to two groups . One group received a daily 20-µg vitamin D3 dose ( n = 54 ) , and the other group received a placebo ( n = 51 ) for 12 weeks . Outcome measures included blood pressure , heart rate , concentrations of renin , aldosterone , serum lipids and vascular calcification markers , and haematologic variables such as pro-inflammatory monocytes . Results Blood pressure and systemic cardiovascular risk markers remained unchanged by vitamin D3 supplementation , although serum 25-hydroxyvitamin D3 increased from 38 ± 14 to 73 ± 16 nmol/L at week 12 . The placebo and vitamin D groups did not differ in their final cardiovascular risk profile . Conclusion Daily supplementation of 20 µg vitamin D3 during winter is unlikely to change cardiovascular risk profile
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .