Conclusions : Compared to age-matched population s , people with ESKD/HD had significantly slower GS and reduced walk distances ; with intervention , the change in the distance walked was significant .
Background : People with end-stage kidney disease ( ESKD ) on hemodialysis ( HD )  commonly have functional impairments .
The purpose of this systematic review was to evaluate the effect of HD on spatio-temporal characteristics of gait , and effect of exercise on these parameters .
Intradialytic protein supplementation reduces inflammation and improves physical function in maintenance hemodialysis patients.
OBJECTIVE Protein malnutrition is both a cause and consequence of inflammation and related comorbidities for maintenance hemodialysis ( MHD ) patients . This study sought to determine if oral supplementation with soy or whey protein during dialysis treatment reduces inflammation and improves physical function and body composition in MHD patients . DESIGN The design used in the study was r and omized controlled trial , and the setting used was hemodialysis clinics in Champaign and Chicago , Illinois . SUBJECTS Patients who received treatment ≥3 days/week , were ages ≥30 years did not have congestive heart failure or chronic obstructive pulmonary disease , and were receiving dialysis treatment for ≥3 months were eligible for inclusion . INTERVENTION Patients were r and omized to oral supplementation with a whey protein , soy protein , or placebo beverage . Patients ( WHEY , n = 11 ; SOY , n = 12 ; CON , n = 15 ) consumed their assigned beverage before every dialysis session for 6 months . MAIN OUTCOME MEASURES Body composition was measured by dual-energy x-ray absorptiometry , physical function by gait speed and shuttle walk test , and markers of inflammation ( C-reactive protein and interleukin 6 ) using commercially available enzyme-linked immunosorbent assay kits before and after the 6-month intervention . Dietary intake was assessed by 24-hour dietary recalls . RESULTS Six months of whey or soy supplementation significantly reduced predialysis interleukin 6 levels ( P < .05 for both ) , whereas there was a trend for a reduction in C-reactive protein when both protein groups were combined ( P = .062 ) . Gait speed and shuttle walk test performance also significantly improved in the protein groups ( P < .05 for both ) . No changes in body composition were observed . However , alkaline phosphatase , a marker of bone turnover , was significantly reduced in the protein groups . CONCLUSIONS Intradialytic protein supplementation during a 6-month intervention reduced inflammation and improved physical function and represents an affordable intervention to improve the health of MHD patients
Conclusions : Compared to age-matched population s , people with ESKD/HD had significantly slower GS and reduced walk distances ; with intervention , the change in the distance walked was significant .
Background : People with end-stage kidney disease ( ESKD ) on hemodialysis ( HD )  commonly have functional impairments .
The purpose of this systematic review was to evaluate the effect of HD on spatio-temporal characteristics of gait , and effect of exercise on these parameters .