In general , stimulants improved driving performance in ADHD patients ( either in RCTs conducted in simulators and /or cars ) .
MPH-OROS  improved driving performance compared with MAS-XR , placebo , or no-drug conditions .
Although MPH-OROS and MPH-IR produced similar improvements during the day , MPH-IR lost its efficacy in the evening .
MAS-XR also improved driving performance , but worsened driving performance in the evening .
Studies with ATX report conflicting results .
Improvement was more consistent in teenagers and young adults .
In general , treatment with psychostimulants or ATX in therapeutic dosages had no negative impact on driving performance of ADHD patients .
To conclude , treatment with stimulants in therapeutic doses improves driving performance in ADHD patients , especially teenagers and young adults
Adults with Attention Deficit Hyperactivity Disorder ( ADHD ) , especially teenagers and young adults , show important car driving impairments , including risky driving , accidents , fines and suspension of driver׳s license .
We systematic ally review ed the efficacy of stimulant and non-stimulant drugs on driving performance of ADHD patients .
The effects of lisdexamfetamine dimesylate on driving behaviors in young adults with ADHD assessed with the Manchester driving behavior questionnaire.
PURPOSE Young adults with ADHD have been shown to be at increased risk for impairment in driving behaviors . Although stimulant medications have proven efficacy in reducing ADHD symptomatology , there is limited knowledge as to their effects on driving behavior . The focus of this report is on assessing the impact of lisdexamfetamine dimesylate ( LDX ) on driving behaviors in young adults with ADHD using a vali date d driving behavior question naire . METHODS This assessment was carried out in the context of a r and omized , double-blind , 6-week , placebo-controlled , parallel- design study of LDX versus placebo .  Subjects were 61 out patients of both sexes , 18 - 26 years of age , who met Diagnostic and Statistical Manual of Mental Disorders , fourth edition , criteria for ADHD . Subjects were r and omized to receive LDX or placebo for 6 weeks . Driving behavior was assessed at baseline and at the end of treatment using a U.S. version of the Manchester Driving Behavior Question naire ( DBQ ) . RESULTS Highly significant improvements were documented on LDX , over placebo , in driving behaviors assessed through the DBQ in measures of driving errors , driving lapses , and a trend toward fewer driving violations . There were no meaningful associations between these DBQ results and previously documented changes in a laboratory driving simulation paradigm or with improvement in symptoms of ADHD assessed through the ADHD rating scale . CONCLUSIONS LDX treatment was associated with significant improvements in self-reported driving behaviors that were independent of improvement in symptoms of ADHD . These results suggest that LDX may reduce behaviors associated with driving risks in young adults with ADHD
In general , stimulants improved driving performance in ADHD patients ( either in RCTs conducted in simulators and /or cars ) .
MPH-OROS  improved driving performance compared with MAS-XR , placebo , or no-drug conditions .
Although MPH-OROS and MPH-IR produced similar improvements during the day , MPH-IR lost its efficacy in the evening .
MAS-XR also improved driving performance , but worsened driving performance in the evening .
Studies with ATX report conflicting results .
Improvement was more consistent in teenagers and young adults .
In general , treatment with psychostimulants or ATX in therapeutic dosages had no negative impact on driving performance of ADHD patients .
To conclude , treatment with stimulants in therapeutic doses improves driving performance in ADHD patients , especially teenagers and young adults
Adults with Attention Deficit Hyperactivity Disorder ( ADHD ) , especially teenagers and young adults , show important car driving impairments , including risky driving , accidents , fines and suspension of driver׳s license .
We systematic ally review ed the efficacy of stimulant and non-stimulant drugs on driving performance of ADHD patients .