Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .
Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo.
OBJECTIVES To investigate the effectiveness and safety of a red clover isoflavone dietary supplement ( Promensil , Novogen Ltd. , Australia ) versus placebo on the change in hot flush frequency in postmenopausal women . METHODS In this r and omized , double blind , placebo-controlled trial 30 women with more than 12 months amenorrhoea and experiencing more than five flushes per day were enrolled . All received single blind placebo tablets for 4 weeks and were subsequently r and omized to either placebo or 80 mg isoflavones for a further 12 weeks . Efficacy was measured by the decrease in number of hot flushes per day and changes in Greene Climacteric Scale Score . RESULTS During the first 4 weeks of placebo the frequency of hot flushes decreased by 16 % . During the subsequent double blind phase , a further , statistically significant decrease of 44 % was seen in isoflavones group ( P<0.01 ) , whereas no further reduction occurred within the placebo group . The Greene score decreased in the active group by 13 % and remained unchanged in the placebo group . CONCLUSION In this study , treatment with 80 mg isoflavones ( Promensil ) per day result ed in a significant reduction in hot flushes from baseline . At the end of the study there was a significant decrease in hot flushes of 44 % between the active and placebo group , demonstrating the effectiveness of Promensil in the management of hot flushes
Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .