In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Serum fructosamine versus glycosylated hemoglobin as an index of glycemic control, hospitalization, and infection in diabetic hemodialysis patients.
Diabetes is the most common cause of end-stage renal disease and an important risk factor for morbidity and mortality in dialysis patients . Glycemic control , utilizing serial measurement of glycosylated hemoglobin ( HbA1c ) , is generally recommended to limit end-organ damage , including cardiovascular morbidity and mortality . We , along with others , have previously suggested that HbA1c may not be a reliable measure of glycemic control in dialysis patients , and have therefore explored the use of serum fructosamine ( SF ) as an alternative marker . The objective of this study was to compare HbA1c levels with SF in monitoring glycemic control and associated morbidity ( infection and hospitalization ) in diabetic patients in a large urban hemodialysis ( HD ) center . We enrolled 100 diabetic HD patients and followed them up prospect ively for 3 years . Data on demographics , as well as biochemical and clinical data , including hospitalizations and infections , were recorded . The mean age was 63 years . In all 54 % were women and the majority were African Americans ( 72 % ) . As expected , HbA1c and albumin-corrected fructosamine ( AlbF ) levels were highly correlated and both were significantly associated with serum glucose . AlbF , however , was more highly correlated with mean glucose values when less than 150 mg/dl and was a more useful predictor of morbidity . By univariate logistic regression and by Poisson regression analysis , AlbF , but not HbA1c , was a significant predictor of hospitalization . Additionally , in patients dialyzed by arteriovenous ( AV ) access ( that is , excluding those dialyzed via vascular catheters ) , AlbF , but not HbA1c , was a significant predictor of infection . In conclusion , AlbF is as reliable a marker as HbA1c for glycemic control in diabetic patients on HD , and may be advantageous for patients with serum glucose in a desirable therapeutic range ( < 150 mg/dl ) . In addition , AlbF , but not HbA1c , is associated with morbidity ( hospitalizations and infections ) in diabetic patients on HD
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .