Data concerning effects of aspartame on main metabolic variables associated to diabetes and obesity do not support a beneficial related to its consumption
ABSTRACT Data about harms or benefits associated with the consumption of aspartame , a nonnutritive sweetener worldwide consumed , are still controversial .
This systematic review and meta- analysis of r and omized controlled clinical trials aim ed to assess the effect of aspartame consumption on  metabolic parameters related to diabetes and obesity .
Aspartame Sensitivity? A Double Blind Randomised Crossover Study
Background Aspartame is a commonly used intense artificial sweetener , being approximately 200 times sweeter than sucrose . There have been concerns over aspartame since approval in the 1980s including a large anecdotal data base reporting severe symptoms . The objective of this study was to compare the acute symptom effects of aspartame to a control preparation . Methods This was a double-blind r and omized cross over study conducted in a clinical research unit in United Kingdom . Forty-eight individual who has self reported sensitivity to aspartame were compared to 48 age and gender matched aspartame non-sensitive individuals . They were given aspartame (100mg)-containing or control snack bars r and omly at least 7 days apart . The main outcome measures were acute effects of aspartame measured using repeated ratings of 14 symptoms , biochemistry and metabonomics . Results Aspartame sensitive and non-sensitive participants differed psychologically at baseline in h and ling feelings and perceived stress . Sensitive participants had higher triglycerides ( 2.05 ± 1.44 vs. 1.26 ± 0.84mmol/L ; p value 0.008 ) and lower HDL-C ( 1.16 ± 0.34 vs. 1.35 ± 0.54 mmol/L ; p value 0.04 ) , reflected in 1H NMR serum analysis that showed differences in the baseline lipid content between the two groups . Urine metabonomic studies showed no significant differences . None of the rated symptoms differed between aspartame and control bars , or between sensitive and control participants . However , aspartame sensitive participants rated more symptoms particularly in the first test session , whether this was placebo or control . Aspartame and control bars affected GLP-1 , GIP , tyrosine and phenylalanine levels equally in both aspartame sensitive and non-sensitive subjects . Conclusion Using a comprehensive battery of psychological tests , biochemistry and state of the art metabonomics there was no evidence of any acute adverse responses to aspartame . This independent study gives reassurance to both regulatory bodies and the public that acute ingestion of aspartame does not have any detectable psychological or metabolic effects in humans . Trial Registration IS RCT N Registry IS RCT
Data concerning effects of aspartame on main metabolic variables associated to diabetes and obesity do not support a beneficial related to its consumption
ABSTRACT Data about harms or benefits associated with the consumption of aspartame , a nonnutritive sweetener worldwide consumed , are still controversial .
This systematic review and meta- analysis of r and omized controlled clinical trials aim ed to assess the effect of aspartame consumption on  metabolic parameters related to diabetes and obesity .