Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .
Effects of oat and wheat bread consumption on lipid profile, blood sugar, and endothelial function in hypercholesterolemic patients: A randomized controlled clinical trial
BACKGROUND Increased lipid profile after each meal can disturb the endothelial function . The present study assessed the effects of bread supplemented with oat bran on serum lipids and endothelial dysfunction in patients with hypercholesterolemia . METHODS This clinical trial was conducted on 60 isolated hypercholesterolemic patients . The subjects were r and omly allocated to either intervention ( consuming at least five daily servings of oat bread with 6 g beta-glucan ) or control ( receiving at least five servings of wheat bread ) . Anthropometric indicators , fasting blood sugar and lipid profiles ere measured at baseline and after 6 weeks ( in the end of the intervention ) . Endothelial function was assessed using flow-mediated dilation ( FMD ) . Within the group and between group differences were investigated using paired t-test and Student ’s t-test , respectively . RESULTS Oat bread consumption could significantly reduce total cholesterol ( P = 0.029 ) . A significant increase in baseline and after ischemia brachial artery diameters at the end of the study was seen . However , it did not have a significant effect on FMD ( P = 0.825 ) . In the control group , none of the measured indices had changed significantly at the end of the study . Finally , only the mean change of brachial artery diameter after ischemia and baseline brachial artery diameter were significantly higher in the intervention group than in the control group ( P = 0.036 and P = 0.012 respectively ) . CONCLUSION Oat bread with beta-glucan could successfully reduce cholesterol levels . Furthermore , in this study oat bread did not reduce FMD more than wheat bread . Since hypercholesterolemia is a proven risk factor for endothelial dysfunction , hypercholesterolemic patients can hence be advised to eat oat bread
Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .