The MFSI-SF demonstrated moderate test-retest reliability in a small number of studies .
The MFSI-SF fatigue subscales were positively correlated with measures of distress , depressive , and anxious symptoms .
Purpose Fatigue is a subjective complaint that is believed to be multifactorial in its etiology and multidimensional in its expression .
Fatigue may be experienced by individuals in different dimensions as physical , mental , and emotional tiredness .
The purpose s of this study were to review and characterize the use of the 30-item Multidimensional Fatigue Symptom Inventory-Short Form ( MFSI-SF ) in published studies and to evaluate the available evidence for its psychometric properties .
A Phase II Study with Antioxidants, Both in the Diet and Supplemented, Pharmaconutritional Support, Progestagen, and Anti-Cyclooxygenase-2 Showing Efficacy and Safety in Patients with Cancer-Related Anorexia/Cachexia and Oxidative Stress
Purpose : To test the efficacy and safety of an integrated treatment based on a pharmaconutritional support , antioxidants , and drugs , all given orally , in a population of advanced cancer patients with cancer-related anorexia/cachexia and oxidative stress . Patients and Methods : An open early-phase II study was design ed according to the Simon two-stage design . The integrated treatment consisted of diet with high polyphenols content ( 400 mg ) , antioxidant treatment ( 300 mg/d α-lipoic acid + 2.7 g/d carbocysteine lysine salt + 400 mg/d vitamin E + 30,000 IU/d vitamin A + 500 mg/d vitamin C ) , and pharmaconutritional support enriched with 2 cans per day (n-3)-PUFA ( eicosapentaenoic acid and docosahexaenoic acid ) , 500 mg/d medroxyprogesterone acetate , and 200 mg/d selective cyclooxygenase-2 inhibitor celecoxib . The treatment duration was 4 months . The following variables were evaluated : ( a ) clinical ( Eastern Cooperative Oncology Group performance status ) ; ( b ) nutritional [ lean body mass ( LBM ) , appetite , and resting energy expenditure ] ; ( c ) laboratory [ proinflammatory cytokines and leptin , reactive oxygen species ( ROS ) and antioxidant enzymes ] ; ( d ) quality of life ( European Organization for Research and Treatment of Cancer QLQ-C30 , Euro QL-5D , and MFSI-SF ) . Results : From July 2002 to January 2005 , 44 patients were enrolled . Of these , 39 completed the treatment and were assessable . Body weight increased significantly from baseline as did LBM and appetite . There was an important decrease of proinflammatory cytokines interleukin-6 ( IL-6 ) and tumor necrosis factor-α , and a negative relationship worthy of note was only found between LBM and IL-6 changes . As for quality of life evaluation , there was a marked improvement in the European Organization for Research and Treatment of Cancer QLQ-C30 , Euro QL-5DVAS , and multidimensional fatigue symptom inventory-short form scores . At the end of the study , 22 of the 39 patients were “ responders ” or “ high responders . ” The minimum required was 21 ; therefore , the treatment was effective and more importantly was shown to be safe . Conclusion : The efficacy and safety of the treatment have been shown by the study ; therefore , a r and omized phase III study is warranted . ( Cancer Epidemiol Biomarkers Prev 2006;15(5):1030–4
The MFSI-SF demonstrated moderate test-retest reliability in a small number of studies .
The MFSI-SF fatigue subscales were positively correlated with measures of distress , depressive , and anxious symptoms .
Purpose Fatigue is a subjective complaint that is believed to be multifactorial in its etiology and multidimensional in its expression .
Fatigue may be experienced by individuals in different dimensions as physical , mental , and emotional tiredness .
The purpose s of this study were to review and characterize the use of the 30-item Multidimensional Fatigue Symptom Inventory-Short Form ( MFSI-SF ) in published studies and to evaluate the available evidence for its psychometric properties .