Quantitative relations between baseline iron status , study duration , and iron dose on changes in iron-status biomarkers , which were generated from the meta-analyses , can be used to predict effects of trials of iron supplementation and fortification and to design iron-intervention programs
BACKGROUND The response of status biomarkers to an increase in iron supply depends on several physiologic and environmental factors , which make it difficult to predict the outcome of an intervention .
OBJECTIVE We assessed effects of baseline iron status , sex , menopausal status , duration of intervention , iron form , and daily dose on the change in iron status in response to iron supplementation .
Serum ferritin
PURPOSE : There is increasing evidence that screening for colorectal cancer may save lives , and consequently , both professional and public interest in screening for colorectal cancer is increasing . As yet , however , there is no perfect screening test . Insidious blood loss is a common feature of colorectal cancer and may lead to a fall in serum ferritin before the patient becomes anemic . Measurement of serum ferritin , which is widely available and easily and inexpensively performed , has , therefore , been postulated as a potential screening test for colorectal cancer . METHOD : This study used sample s of serum collected from 148 patients recruited to a screening study for colorectal cancer . All patients were thoroughly investigated by double-contrast barium enema and /or colonoscopy .  Patients were selected r and omly from each of three clinical diagnostic groups : 50 patients with proven colorectal cancer , 49 patients without colon disease , and patients with adenomas of the colon .  Serum ferritin was assayed by immunoradiometry . The expected adult reference range is 25 to 350 µg/l , and results were reported without patient identification . RESULTS : There were no significant differences in serum ferritin levels among any of the three groups . CONCLUSION : Serum ferritin is unlikely to be of value as a screening test for colorectal cancer
Quantitative relations between baseline iron status , study duration , and iron dose on changes in iron-status biomarkers , which were generated from the meta-analyses , can be used to predict effects of trials of iron supplementation and fortification and to design iron-intervention programs
BACKGROUND The response of status biomarkers to an increase in iron supply depends on several physiologic and environmental factors , which make it difficult to predict the outcome of an intervention .
OBJECTIVE We assessed effects of baseline iron status , sex , menopausal status , duration of intervention , iron form , and daily dose on the change in iron status in response to iron supplementation .