Antiplatelet agents have a beneficial effect in reducing all cause mortality and fatal cardiovascular events in patients with IC .
BACKGROUND Peripheral arterial disease ( PAD ) is common and is a marker of systemic atherosclerosis .
Patients with symptoms of intermittent claudication ( IC ) are at increased risk of cardiovascular events ( myocardial infa rct ion ( MI ) and stroke ) and of both cardiovascular and all cause mortality .
OBJECTIVES To determine the effectiveness of antiplatelet agents in reducing mortality ( all cause and cardiovascular ) and cardiovascular events in patients with intermittent claudication .
A global view of atherothrombosis: baseline characteristics in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial.
BACKGROUND The manifestations of atherothrombosis such as myocardial infa rct ion , ischemic stroke , limb ischemia , or cardiovascular death pose a global health care burden . Additional therapies to decrease ischemic events in patients with established vascular disease or at risk for developing vascular disease are necessary . We sought to characterize the risk factors and treatments of a diverse contemporary population of patients with atherothrombosis . METHODS The CHARISMA trial has enrolled 15,603 patients from around the world . Patients with established coronary , cerebrovascular , or peripheral arterial disease , or those at high risk of developing atherothrombosis due to multiple risk factors , have been r and omized to receive either the adenosine diphosphate receptor antagonist clopidogrel or placebo , in addition to background therapy with low- to moderate-dose aspirin . RESULTS A high percentage of enrolled patients are being treated with statins and angiotensin-converting enzyme inhibitors . In the CHARISMA population , a total of 75.6 % of the population had an abnormal body mass index : 42.2 % were overweight and 33.4 % were obese , with particularly high rates in the United States , especially of morbid obesity . Correspondingly , the prevalence of diabetes was 42 % . CONCLUSION The CHARISMA trial will further characterize atherothrombosis and provide insight into the role of dual antiplatelet therapy in improving outcomes in patients with multiple risk factors or established vascular disease . Of note , the rates of obesity and diabetes in patients with atherothrombosis throughout the world are particularly alarming
Antiplatelet agents have a beneficial effect in reducing all cause mortality and fatal cardiovascular events in patients with IC .
BACKGROUND Peripheral arterial disease ( PAD ) is common and is a marker of systemic atherosclerosis .
Patients with symptoms of intermittent claudication ( IC ) are at increased risk of cardiovascular events ( myocardial infa rct ion ( MI ) and stroke ) and of both cardiovascular and all cause mortality .
OBJECTIVES To determine the effectiveness of antiplatelet agents in reducing mortality ( all cause and cardiovascular ) and cardiovascular events in patients with intermittent claudication .