The results of this systematic review and meta‐ analysis suggest that probiotic and synbiotic supplementation may help to improve biomarkers of inflammation and oxidative stress in diabetic patients .
Abstract The role of gut microbiota in the management of diabetes has been shown .
Several current trials are investigating the effect of probiotics and prebiotics , which are widely used to modulate intestinal microbiota , on inflammatory factors and biomarkers of oxidative stress in diabetic patients ; however , their findings are controversial .
The aim of the current meta‐ analysis was to evaluate the effects of probiotic and synbiotic supplementation on levels of serum high‐sensitivity C‐reactive protein ( hs‐CRP ) and biomarkers of oxidative stress in diabetic patients .
Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT
Probiotics are widely prescribed for prevention of antibiotics-associated dysbiosis and related adverse effects . However , probiotic impact on post-antibiotic reconstitution of the gut mucosal host-microbiome niche remains elusive . We invasively examined the effects of multi-strain probiotics or autologous fecal microbiome transplantation ( aFMT ) on post-antibiotic reconstitution of the murine and human mucosal microbiome niche . Contrary to homeostasis , antibiotic perturbation enhanced probiotics colonization in the human mucosa but only mildly improved colonization in mice . Compared to spontaneous post-antibiotic recovery , probiotics induced a markedly delayed and persistently incomplete indigenous stool/mucosal microbiome reconstitution and host transcriptome recovery toward homeostatic configuration , while aFMT induced a rapid and near-complete recovery within days of administration . In vitro , Lactobacillus-secreted soluble factors contributed to probiotics-induced microbiome inhibition . Collectively , potential post-antibiotic probiotic benefits may be offset by a compromised gut mucosal recovery , highlighting a need of developing aFMT or personalized probiotic approaches achieving mucosal protection without compromising microbiome recolonization in the antibiotics-perturbed host
The results of this systematic review and meta‐ analysis suggest that probiotic and synbiotic supplementation may help to improve biomarkers of inflammation and oxidative stress in diabetic patients .
Abstract The role of gut microbiota in the management of diabetes has been shown .
Several current trials are investigating the effect of probiotics and prebiotics , which are widely used to modulate intestinal microbiota , on inflammatory factors and biomarkers of oxidative stress in diabetic patients ; however , their findings are controversial .
The aim of the current meta‐ analysis was to evaluate the effects of probiotic and synbiotic supplementation on levels of serum high‐sensitivity C‐reactive protein ( hs‐CRP ) and biomarkers of oxidative stress in diabetic patients .