The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
The influence of long-term ACE inhibitor treatment on circulatory responses to stress in human hypertension.
The objective of the study was to examine the influence of angiotensin converting enzyme ( ACE ) inhibition on circulatory responses to st and ardized stress tests in primary mild to moderate hypertension . Patients ( n = 28 ) received 5 mg ramipril daily or placebo for 6 weeks in a double-blind crossover design , followed by 6 months of open ramipril treatment . Mental stress ( a 20-min Stroop 's color word conflict test ) and a cold pressor test were performed at the end of each of the three study periods . Noninvasive blood pressure and heart rate were recorded . Ramipril reduced systolic and diastolic blood pressure levels at rest ( from 146+/-3/99+/-3 with placebo to 135+/-4/94+/-3 at 6 weeks , and 136+/-4/91+/-3 mm Hg at 6 months , in the laboratory ) and during mental stress . Resting heart rates were unchanged by ramipril . Ramipril reduced systolic blood pressure and heart rate responses during mental stress ; diastolic blood pressure responses were unchanged . Ramipril reduced cardiac workload ( systolic blood pressure x heart rate ) levels and responses . Treatment effects at 6 months were generally greater than at 6 weeks . During the cold pressor test systolic and diastolic blood pressure levels were lowered by ramipril , but responses were unchanged . Heart rate responses , however , were reduced . Thus , ramipril reduced cardiac workload levels and responses also during the cold pressor test . These findings show that ACE inhibitors can reduce cardiac workload during stressful situations . If confirmed , this would seem to offer an advantage in the treatment of hypertension
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .