On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Memantine versus Methylphenidate in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial
Objectives : The aim of this r and omized clinical trial was to assess the efficacy of memantine versus methylpheni date in the treatment of children with attention deficit hyperactivity disorder . Method : Forty participants ( 34 boys and 6 girls ) aged 6 - 11 who were diagnosed with attention deficit hyperactivity disorder based on ( DSM-IV-TR ) criteria were selected for this study . The participants were r and omly assigned to two groups : group one ( n = 22 ) received memantine and the other group ( n = 18 ) received methylpheni date for six weeks . Treatment outcomes were assessed using the Attention Deficit Hyperactivity Rating Scale and Clinical Global Impression- Severity Scale administered at baseline and at weeks 3 and 6 following the treatment . Also , a two-way repeated measures analysis of variance ( time- treatment interaction ) was used . Results : At 6 weeks , methylpheni date produced a signiﬁcantly better outcome on the Parent Rating Scale scores and Clinical Global Impression- Severity than memantine . Side effects were observed more often in the memantine group . However , with respect to the frequency of side effects , the difference between the memantine and methylpheni date groups was not signiﬁcant . The most common side effects associated with memantine  are appetite suppression , headache , vomiting , nausea and fatigue . Conclusion : The results of this study revealed that although memantine was less effective than methylpheni date in the treatment of attention deficit hyperactivity disorder , it may be considered as an alternative treatment
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .