Conclusions Large r and omized controlled trials of at least 6 months duration with carbohydrate restriction appear superior in improving lipid markers when compared with low-fat diets .
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk .
Objective A systematic review and meta-analyses were conducted to compare the effects of very low , low , and moderate carbohydrate , higher fat diets versus high-carbohydrate , low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults .
A Randomized Study Comparing the Effects of a Low-Carbohydrate Diet and a Conventional Diet on Lipoprotein Subfractions and C-reactive Protein Levels in Patients With Severe Obesity.
PURPOSE To compare the effects of a low-carbohydrate diet and a conventional ( fat- and calorie-restricted ) diet on lipoprotein subfractions and inflammation in severely obese subjects . METHODS We compared changes in lipoprotein subfractions and C-reactive protein levels in 78 severely obese subjects , including 86 % with either diabetes or metabolic syndrome , who were r and omly assigned to either a low-carbohydrate or conventional diet for 6 months . RESULTS Subjects on a low-carbohydrate diet experienced a greater decrease in large very low-density lipoprotein ( VLDL ) levels ( difference = -0.26 mg/dL , p = .03 ) but more frequently developed detectable chylomicrons ( 44 % vs 22 % , p = .04 ) . Both diet groups experienced similar decreases in the number of low-density lipoprotein ( LDL ) particles ( difference = -30 nmol/L , p = .74 ) and increases in large high-density lipoprotein ( HDL ) concentrations ( difference = 0.70 mg/dL , p = .63 ) . Overall , C-reactive protein levels decreased modestly in both diet groups . However , patients with a high-risk baseline level ( > 3 mg/dL , n = 48 ) experienced a greater decrease in C-reactive protein levels on a low-carbohydrate diet ( adjusted difference = -2 mg/dL , p = .005 ) , independent of weight loss . CONCLUSIONS In this 6-month study involving severely obese subjects , we found an overall favorable effect of a low-carbohydrate diet on lipoprotein subfractions and on inflammation in high-risk subjects . Both diets had similar effects on LDL and HDL subfractions . ( Am J Med . 2004;117:398 - 405 . )
Conclusions Large r and omized controlled trials of at least 6 months duration with carbohydrate restriction appear superior in improving lipid markers when compared with low-fat diets .
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk .
Objective A systematic review and meta-analyses were conducted to compare the effects of very low , low , and moderate carbohydrate , higher fat diets versus high-carbohydrate , low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults .