SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .
Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts.
This study tested the effectiveness of fluoxetine as a treatment for depression in a population of methadone-maintained opioid addicts . Methadone-maintained opioid addicts ( 44 ) with depression received fluoxetine or placebo in addition to their methadone , in a double-blind r and omized trial , for 12 weeks . Depressive symptoms decreased significantly overall with no significant differences between the groups treated with fluoxetine versus placebo . In addition , drug use outcomes , including cocaine and heroin self-reported use and urine toxicology were measured . There was a significant decrease in heroin use in treatment , but no medication effect . Cocaine use , was unchanged from pre-treatment to endpoint . In separately analyzing data for the sub sample of subjects with the most severe depression , there was a significant decrease in depression during treatment and a significant decrease in self-reported cocaine use , but no medication effect on either depressive symptoms or on cocaine use . This study suggests that fluoxetine is not an effective agent in treating depression or cocaine use in this population
SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .