Despite limitations in these data , our NMA findings are in line with existing evidence on the metabolic effects of fat and support current recommendations to replace high saturated-fat food with unsaturated oils
The aim of this network meta- analysis ( NMA ) is to compare the effects of different oils/solid fats on blood lipids .
Palmitic acid in the sn-2 position of dietary triacylglycerols does not affect insulin secretion or glucose homeostasis in healthy men and women
Background / objectives : Dietary triacylglycerols containing palmitic acid in the sn-2 position might impair insulin release and increase plasma glucose . Subjects/ Methods : We used a cross-over design ed feeding trial in 53 healthy Asian men and women ( 20–50 years ) to test this hypothesis by exchanging 20 % energy of palm olein ( PO ; control ) with r and omly interesterified PO ( IPO ) or high oleic acid sunflower oil ( HOS ) . After a 2-week run-in period on PO , participants were fed PO , IPO and HOS for 6 week consecutively in r and omly allocated sequences . Fasting ( midpoint and endpoint ) and postpr and ial blood at the endpoint following a test meal ( 3.54 MJ , 14 g protein , 85 g carbohydrate and 50 g fat as PO ) were collected for the measurement of C-peptide , insulin , glucose , plasma glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 , lipids and apolipoproteins ; pre-specified primary and secondary outcomes were postpr and ial changes in C-peptide and plasma glucose . Results : Low density lipoprotein cholesterol was 0.3 mmol/l ( 95 % confidence interval ( 95 % CI ) ) 0.1 , 0.5 ; P<0.001 ) lower on HOS than on PO or IPO as predicted , indicating good compliance to the dietary intervention . There were no significant differences ( P=0.58 ) between diets among the 10 male and 31 female completers in the incremental area under the curve ( 0–2 h ) for C-peptide in nmol.120 min/l : GM ( 95 % CI ) were PO 220 ( 196 , 245 ) , IPO 212 ( 190 , 235 ) and HOS 224 ( 204 , 244 ) . Plasma glucose was 8 % lower at 2 h on IPO vs PO and HOS ( both P<0.05 ) . Conclusion : Palmitic acid in the sn-2 position does not adversely impair insulin secretion and glucose homeostasis
Despite limitations in these data , our NMA findings are in line with existing evidence on the metabolic effects of fat and support current recommendations to replace high saturated-fat food with unsaturated oils
The aim of this network meta- analysis ( NMA ) is to compare the effects of different oils/solid fats on blood lipids .