Results show that various classes of antidepressants exert improving effects on cognitive function across several cognitive domains .
Specifically , studies suggest that SSRIs , the SSRE tianeptine , the SNRI duloxetine , vortioxetine and other antidepressants such as bupropion and moclobemide may exert certain improving effects on cognitive function in depression , such as in learning and memory and executive function .
The few non-pharmacological studies conducted employing cognitive orientated treatments and cognitive remediation therapy show promising results for the improvement of cognitive impairment in depression .
Cognitive dysfunction is of clinical significance and exerts longst and ing implication on patients ׳ function .
Pharmacological and non-pharmacological treatments of cognitive dysfunction are emerging .
This review evaluates pharmacological and non-pharmacological treatments of cognitive impairment primarily in the domains of memory , attention , processing speed and executive function in clinical depression .
Tianeptine therapy for depression in the elderly
1 . Depression is frequent in the elderly but difficult both to diagnose and treat due to a number of distinctive features . 2 . Tianeptine is a novel antidepressant with a reverse mode of action to that of the selective serotonin reuptake inhibitors yet with proven efficacy and safety . 3 . 63 elderly patients ( mean age:68.8 years ; range:65 - 80 years ) with depressive symptoms ( major depression:55.6 % ; dysthymia:44.4 % ) were included in a 3-month open multicenter study with tianeptine ( 25 mg daily ) . 4 . 43 patients ( 68.2 % ) completed the study . There were no drop-outs due to side-effects . Total Montgomery and Asberg Depression Rating Scale scores were significantly decreased ( p < 0.01 ) on day 14 , with a response rate of 76.7 % . 5 . Improvements were also observed in anxiety and cognitive performance . Side-effects were seen in only 11.7 % of patients , with no changes in laboratory or ancillary safety parameters . Tianeptine is thus effective and well tolerated in this category of patient
Results show that various classes of antidepressants exert improving effects on cognitive function across several cognitive domains .
Specifically , studies suggest that SSRIs , the SSRE tianeptine , the SNRI duloxetine , vortioxetine and other antidepressants such as bupropion and moclobemide may exert certain improving effects on cognitive function in depression , such as in learning and memory and executive function .
The few non-pharmacological studies conducted employing cognitive orientated treatments and cognitive remediation therapy show promising results for the improvement of cognitive impairment in depression .
Cognitive dysfunction is of clinical significance and exerts longst and ing implication on patients ׳ function .
Pharmacological and non-pharmacological treatments of cognitive dysfunction are emerging .
This review evaluates pharmacological and non-pharmacological treatments of cognitive impairment primarily in the domains of memory , attention , processing speed and executive function in clinical depression .