Probiotic interventions were effective for treatment and prevention of BV , prevention of recurrences of c and idiasis and UTIs , and clearing HPV lesions .
Although clinical practice recommendations were limited by the strength of evidence , probiotic interventions were effective in treatment and prevention of urogenital infections as alternatives or co-treatments .
INTRODUCTION Probiotics are a complementary and integrative therapy useful in the treatment and prevention of urogenital infections in women .
This study extends the work of research ers who systematic ally investigated the scientific literature on probiotics to prevent or treat urogenital infections .
Can Lactobacillus fermentum LF10 and Lactobacillus acidophilus LA02 in a Slow-release Vaginal Product be Useful for Prevention of Recurrent Vulvovaginal Candidiasis?: A Clinical Study
Objective : To assess the effectiveness of the association of 2 specific strains , Lactobacillus fermentum LF10 ( DSM 19187 ) and Lactobacillus acidophilus LA02 ( DSM 21717 ) , specifically formulated in slow-release effervescent tablets , in patients with recurrent vulvovaginal c and idiasis . Study Design : The study was a clinical trial of 58 women diagnosed with recurrent VVC ( ≥4 culture-confirmed episodes in a 12-mo period ) . All patients were given 200 mg of fluconazole orally as an induction dose for 3 alternate days during the first treatment week . Afterward , the patients were given a new product formulated in slow-release vaginal tablets containing at least 0.4 billion live cells of each of lactobacillus L. fermentum LF10 and L. acidophilus LA02 ( first phase of the prophylactic period ) , on alternate days for 10 consecutive nights . Patients who were still free of symptoms were given 1 vaginal tablet every week for the next 10 weeks ( second phase of the prophylactic period ) . Patients asymptomatic after the total duration of the observation phase ( 7 mo ) were considered as responders . Results : During the second 10-week prophylactic phase , 49 of 57 ( 86.0 % ) patients remained free of clinical recurrence , whereas symptomatic VVC occurred in 8 patients ( 14.0 % ) . During the 7-month follow-up , 42 patients of 49 ( 85.7 % ) were symptom free at the end of the protocol , whereas clinical recurrences occurred in 7 women ( 14.3 % ) . Overall , 42 of 58 women enrolled in the study ( 72.4 % ) experienced no clinical recurrence throughout the 7-month observation phase ( responders ) . Conclusions : This study strengthens the evidence supporting the use of specific lactobacilli with well-demonstrated activities associated with the creation and maintenance of a vaginal biofilm that hinders the persistence of an infection caused by C and ida
Probiotic interventions were effective for treatment and prevention of BV , prevention of recurrences of c and idiasis and UTIs , and clearing HPV lesions .
Although clinical practice recommendations were limited by the strength of evidence , probiotic interventions were effective in treatment and prevention of urogenital infections as alternatives or co-treatments .
INTRODUCTION Probiotics are a complementary and integrative therapy useful in the treatment and prevention of urogenital infections in women .
This study extends the work of research ers who systematic ally investigated the scientific literature on probiotics to prevent or treat urogenital infections .