The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
Supragingival irrigation with 0.06% chlorhexidine in naturally occurring gingivitis. I. 6 month clinical observations.
The purpose of this study was to assess the efficacy of supragingival irrigation with 0.06 % chlorhexidine gluconate ( CHX ) on naturally occurring gingivitis . The relative benefit of CHX irrigation in comparison with CHX rinsing , water irrigation , and normal oral hygiene was evaluated . In a blind , placebo-controlled 6-month study 222 patients were assigned to one of four groups : Group 1 : Once daily irrigation with 300 ml water followed by irrigation with 200 ml 0.06 % chlorhexidine gluconate ( experimental ) ; Group 2 : Twice daily rinsing with 15 ml 0.12 % chlorhexidine ( positive control ) ; Group 3 : Once daily irrigation with 500 ml water ( irrigation control ) and Group 4 : Sodium fluoride dentifrice for normal oral hygiene only ( negative control ) . All groups used the same sodium fluoride dentifrice for tooth brushing . At baseline , 3 months , and 6 months patients were examined for Gingival Index ( GI ) , Bleeding on Probing ( BOP ) , Plaque Index ( PLI ) , Pocket probing depth ( PD ) , Calculus Index ( CI ) , and stain . After the baseline visit all patients received a supra- and subgingival oral prophylaxis . At 6 months GI and BOP were significantly ( P less than or equal to 0.05 ) reduced by adjunctive CHX irrigation ( 42.5 % and 35.4 % , respectively ) , CHX rinse ( 24.1 % and 15.0 % ) , and water irrigation ( 23.1 % and 24.0 % ) compared to tooth brushing alone . Plaque was significantly ( P less than or equal to 0.05 ) reduced only by CHX irrigation ( 53.2 % ) and CHX rinse ( 43.3 % ) while calculus and staining were significantly ( P less than or equal to 0.05 ) increased in the two chlorhexidine groups ( 276.4 % ( irrigation ) and 273.2 % ( rinse ) ) . Although significant ( P less than or equal to 0.05 ) , pocket probing depth reduction was minimal after CHX irrigation ( 4.6 % ) . ( ABSTRACT TRUNCATED AT 250 WORDS
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .