The only eligible r and omised clinical trial did not demonstrate any consistent effects of NIRS plus a guideline on the assessed clinical outcomes .
The trial was , however , only powered to detect difference in cerebral oxygenation , not morbidities or mortality .
BACKGROUND Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants .
Cerebral near-infrared spectroscopy ( NIRS ) enables continuous estimation of cerebral oxygenation .
This diagnostic method coupled with appropriate interventions if NIRS is out of normal range ( that is cerebral oxygenation within the 55 % to 85 % range ) may offer benefits without causing more harms .
Therefore , NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of r and omised clinical trials and quasi-r and omised studies .
OBJECTIVES To evaluate the benefits and harms of interventions that attempt to alter cerebral oxygenation guided by cerebral NIRS monitoring in order to prevent cerebral injury , improve neurological outcome , and increase survival in preterm infants born more than 8 weeks preterm .
Monitoring Brain Oxygen Saturation During Coronary Bypass Surgery: A Randomized, Prospective Study
BACKGROUND : Cerebral deoxygenation is associated with various adverse systemic outcomes . We hypothesized , by using the brain as an index organ , that interventions to improve cerebral oxygenation would have systemic benefits in cardiac surgical patients . METHODS : Two-hundred coronary artery bypass patients were r and omized to either intraoperative cerebral regional oxygen saturation ( rSO2 ) monitoring with active display and treatment intervention protocol ( intervention , n = 100 ) , or underwent blinded rSO2 monitoring ( control , n = 100 ) . Predefined clinical outcomes were assessed by a blinded observer . RESULTS : Significantly more patients in the control group demonstrated prolonged cerebral desaturation ( P = 0.014 ) and longer duration in the intensive care unit ( P = 0.029 ) versus intervention patients . There was no difference in overall incidence of adverse complications , but significantly more control patients had major organ morbidity or mortality ( death , ventilation > 48 h , stroke , myocardial infa rct ion , return for re-exploration ) versus intervention group patients ( P = 0.048 ) . Patients experiencing major organ morbidity or mortality had lower baseline and mean rSO2 , more cerebral desaturations and longer lengths of stay in the intensive care unit and postoperative hospitalization , than patients without such complications . There was a significant ( r2 = 0.29 ) inverse correlation between intraoperative rSO2 and duration of postoperative hospitalization in patients requiring ≥10 days postoperative length of stay . CONCLUSION : Monitoring cerebral rSO2 in coronary artery bypass patients avoids profound cerebral desaturation and is associated with significantly fewer incidences of major organ dysfunction
The only eligible r and omised clinical trial did not demonstrate any consistent effects of NIRS plus a guideline on the assessed clinical outcomes .
The trial was , however , only powered to detect difference in cerebral oxygenation , not morbidities or mortality .
BACKGROUND Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants .
Cerebral near-infrared spectroscopy ( NIRS ) enables continuous estimation of cerebral oxygenation .
This diagnostic method coupled with appropriate interventions if NIRS is out of normal range ( that is cerebral oxygenation within the 55 % to 85 % range ) may offer benefits without causing more harms .
Therefore , NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of r and omised clinical trials and quasi-r and omised studies .
OBJECTIVES To evaluate the benefits and harms of interventions that attempt to alter cerebral oxygenation guided by cerebral NIRS monitoring in order to prevent cerebral injury , improve neurological outcome , and increase survival in preterm infants born more than 8 weeks preterm .