The available evidence suggests the early changes in cognition may predict treatment response in individuals with MDD .
The results depict an emerging trend towards early changes in facial emotion recognition ( i.e. , a hot cognitive process ) as a predictor of treatment outcome .
Conclusion : The identification of reliable early treatment predictors of antidepressant response would be clinical ly significant , enabling clinicians to more accurately evaluate the efficacy of selected treatment avenues .
HIGHLIGHTSCognitive dysfunction is a principal feature and determinant of health outcome in MDD.Cognitive changes have shown to occur prior to improvements in mood symptoms .
Early changes in emotional processing may predict treatment response in MDD
Background : Despite the widespread use of antidepressants in clinical practice , the current trial‐ and ‐error approach to medication selection contributes to treatment failure and underscores the need to identify reliable predictors of antidepressant response .
Since changes in measures of cognition have been reported to occur early in treatment and prior to improvements in overall mood symptoms , the present review aims to determine whether early changes in measures of cognition can predict response in individuals with MDD .
Acute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers
Enhancement of serotonin neurotransmission plays an important role in the antidepressant response to agents presently available to treat depression . This response forms the major evidence for the role of serotonin in affective and social behaviour in humans . The present study investigated the effects of acute administration of the selective serotonin reuptake inhibitor ( SSR1 ) , citalopram ( 10 mg , i.v . ) upon a measure of emotional processing in healthy female volunteers . Subjects completed a facial expression recognition task following infusion of citalopram or saline ( between-subjects design , double-blind ) . Facial expressions associated with five basic emotions — happiness , sadness , fearfulness , anger and disgust — were displayed . Each face had been ‘ morphed ’ between neutral ( 0 % ) and each emotional st and ard ( 100 % ) in 10 % steps , leading to a range of emotional intensities . Mood and subjective experience were also monitored throughout the testing session . Volunteers receiving citalopram detected a higher number of facial expressions of fear and happiness , with reduced response times , relative to those given the placebo . By contrast , changes in the recognition of other basic emotions were not observed following citalopram . Notable differences in mood were also not apparent in these volunteers . These results suggest that acute administration of antidepressant drugs may affect neural processes involved in the processing of social information . This effect may represent an early acute effect of SSRIs on social and emotional processing that is relevant to their therapeutic actions
The available evidence suggests the early changes in cognition may predict treatment response in individuals with MDD .
The results depict an emerging trend towards early changes in facial emotion recognition ( i.e. , a hot cognitive process ) as a predictor of treatment outcome .
Conclusion : The identification of reliable early treatment predictors of antidepressant response would be clinical ly significant , enabling clinicians to more accurately evaluate the efficacy of selected treatment avenues .
HIGHLIGHTSCognitive dysfunction is a principal feature and determinant of health outcome in MDD.Cognitive changes have shown to occur prior to improvements in mood symptoms .
Early changes in emotional processing may predict treatment response in MDD
Background : Despite the widespread use of antidepressants in clinical practice , the current trial‐ and ‐error approach to medication selection contributes to treatment failure and underscores the need to identify reliable predictors of antidepressant response .
Since changes in measures of cognition have been reported to occur early in treatment and prior to improvements in overall mood symptoms , the present review aims to determine whether early changes in measures of cognition can predict response in individuals with MDD .