CONCLUSIONS Supplementation with vitamin D showed no effect on adiposity measures in adults
CONTEXT The independent or interactive effects of vitamin D and calcium on adiposity remain inconclusive .
OBJECTIVE The objective of this systematic review and meta- analysis was to assess whether vitamin D and calcium supplements cause changes in adiposity .
Treatment with one-alpha-hydroxycholecalciferol in middle-aged men with impaired glucose tolerance--a prospective randomized double-blind study.
Experimental evidence suggests a specific role for the active metabolite of vitamin D ( 1,25(OH)2D3 ) in insulin secretion . In order to evaluate the possible clinical significance , 65 middle-aged men with impaired glucose tolerance , and normal serum levels of vitamin D metabolites , were enrolled in a three-month study where they were given either 0.75 micrograms alpha-calcidol ( 1 alpha(OH)D3 ) daily or placebo .  Indices of glucose and lipid metabolism were evaluated before and after treatment . There were no significant changes during the trial neither for fasting blood glucose , hemoglobin A1c or for the intravenous glucose tolerance between the treatment and the placebo groups , nor were there any consistent changes in insulin values during the glucose tolerance test . Subjects treated with alpha-calcidol displayed a significant reduction in body weight with an average of 1.1 kg , while those receiving placebo lost no weight . Treatment did not affect the serum lipoprotein values . Thus , a modest dose of active vitamin D , which did not cause elevation of serum calcium , did not provide general improvement of glucose tolerance or of insulin secretion when given to patients with impaired glucose tolerance , but without vitamin D deficiency , over a three-month period
CONCLUSIONS Supplementation with vitamin D showed no effect on adiposity measures in adults
CONTEXT The independent or interactive effects of vitamin D and calcium on adiposity remain inconclusive .
OBJECTIVE The objective of this systematic review and meta- analysis was to assess whether vitamin D and calcium supplements cause changes in adiposity .