There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Plasma lipid and apolipoprotein concentrations in full term infants fed formula supplemented with long-chain polyunsaturated fatty acids and cholesterol
Abstract Recent data indicate that supplementation of infant formula with ω-3 and ω-6 long-chain polyunsaturated fatty acids might offer developmental benefits for full term infants . We investigated biochemical consequences of feeding formula supplemented with egg lipids to provide long-chain polyunsaturated fatty acids and compared triglyceride , cholesterol , lipoprotein cholesterol ( HDL2-cholesterol , HDL3-cholesterol , non-HDL-cholesterol ) and apolipoprotein A-I , A-II and B concentrations in full term infants fed either conventional formula ( n = 10 ) or a formula supplemented with ω-3 and ω-6 long-chain polyunsaturated fatty acids and cholesterol  in amounts similar to those found in mature human milk ( n = 12 ) . At the age of 5 days , cholesterol , non-HDL-cholesterol and triglyceride concentrations were significantly higher in infants fed supplemented than in those receiving conventional formula . At the age of 30 days , triglyceride concentrations were significantly higher with supplemented than with conventional formula . Thereafter throughout the study , no significant differences were seen between the two groups . Conclusion Full term infants  fed formula supplemented with ω-3 and ω-6 long-chain polyunsaturated fatty acids and cholesterol showed significantly higher plasma cholesterol and triglyceride concentrations than infants receiving conventional formula on day 5 and on days 5 and 30 , respectively . Thereafter no appreciable effect of diet on plasma phospholipid , triglyceride , cholesterol , lipoprotein cholesterol and apolipoprotein concentrations were seen
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .