Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .
Effects of the adjunctive probiotic VSL#3 on portal haemodynamics in patients with cirrhosis and large varices: a randomized trial.
BACKGROUND Probiotics , by altering gut flora , may favourably alter portal haemodynamics in patients with cirrhosis . AIM To investigate the effect of probiotics on portal pressure in patients with cirrhosis . METHODS R and omized double-blind placebo-controlled trial conducted in G.B. Pant Hospital , New Delhi . A total of 94 cirrhotic patients having large oesophageal varices without history of variceal bleeding were r and omized to three treatment groups and given 2 months ' treatment with propranolol plus placebo , propranolol plus antibiotics ( norfloxacin 400 mg BD ) or propranolol plus probiotic ( VSL#3 , 900 billion/day ) r and omly assigned in 1:1:1 ratio . Outcome measures were change in Hepatic venous pressure gradient ( HVPG ) : Response rate ( Percentage of patients having a decrease from baseline of ≥20 % or to ≤12 mm Hg ) and changes from baseline ; biochemical markers of inflammation : changes from baseline . RESULTS Adjunctive probiotics  increased the response rate compared with propranolol alone ( 58 % vs. 31 % , P = 0.046 ) , similar to adjunctive antibiotics ( 54 % ) . The mean fall in HVPG was greater with either adjunctive probiotics ( 3.7 mm Hg vs. 2.1 mm Hg , P = 0.061 ) or adjunctive antibiotics ( 3.4 mm Hg ) than with propranolol alone . Both adjunctive therapies were associated with greater decreases in TNF-α levels ( in both peripheral and hepatic venous blood ) that result ed from propranolol-only treatment . No clinical ly relevant between-group differences were observed in the type or frequency of adverse events . CONCLUSIONS Adjunctive probiotic ( VSL#3 ) improved the response  rate to propranolol therapy and was safe and well tolerated in patients with cirrhosis .  Adjunctive probiotic therapy merits further study for reduction in portal pressure
Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .