LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Efficacy and safety of pravastatin in patients with primary hypercholesterolemia. II. Once-daily versus twice-daily dosing.
This 8-week multicenter , placebo-controlled trial compared the efficacy and safety of the HMG-CoA reductase inhibitor , pravastatin , when administered either as single doses of 40 mg in the morning ( AM ) or evening ( PM ) or 20 mg twice daily ( bid ) in 196 diet-stabilized out patients with primary type II hypercholesterolemia . Mean reductions in total and low-density lipoprotein ( LDL ) cholesterol concentrations were observed in all pravastatin groups after 1 week and were sustained throughout the study ( P less than or equal to 0.001 versus baseline and placebo ) . At week 8 , mean reductions from baseline in the pravastatin treatment groups were 23 - 27 % for total cholesterol and 30 - 34 % for LDL cholesterol . LDL cholesterol was reduced greater than or equal to 15 % by pravastatin in all patients in the group treated with 40 mg PM and in 88 and 96 % in those receiving 20 mg bid and 40 mg AM , respectively . High density lipoprotein cholesterol was elevated ( up to 8 % ) and triglycerides were reduced ( up to 25 % ) by all pravastatin regimens ( P less than or equal to 0.05 ) . Pravastatin was well tolerated and was associated with a low incidence of adverse events . No patient withdrew from the study due to a pravastatin-related  adverse event . Once-daily pravastatin is a safe and effective treatment for patients with primary hypercholesterolemia and has a favorable safety profile
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .