Although this study did not consider placebo effect and has high IPSS baseline scores , this study clarifies that low-dose tamsulosin has generally positive effect and safety in treatment of LUTS and could be a suitable option as an initial treatment , especially for patients with low body mass index , as is typical of Asian people
PURPOSE In Asian countries , low-dose tamsulosin ( 0.2 mg ) is used widely but this dose has been less popular than 0.4 mg tamsulosin or other types of alpha blockers .
The aim of this study was to investigate the efficacy and safety of low-dose tamsulosin by systematic review and meta- analysis .
[The clinical efficacy of Naftopidil tablet in the treatment of benign prostatic hyperplasia].
OBJECTIVES To evaluate the clinical efficacy and safety of Naftopidil tablet in treating benign prostatic hyperplasia . METHODS Eighty BPH patients were divided into two groups r and omly by double-blind , double-simulated and active control parallel study trials . Forty patients in treatment group were given Naftopidil tablet 25 mg , p.o . , qn for 42 days , while 40 patients in control group were given Tamsulosin 0.2 mg , p.o . , qn for 42 days . Statistical analysis was given from 77 cases in the groups . Estimation of the efficacy was done by the change of major indexes include international prostate symptom score ( IPSS ) , maximum flowrate ( Qmax ) and secondary indexes such as quality of life ( QOL ) , residual urine ( Ru ) and volume of prostate ( V ) . RESULTS The changes of IPSS , Qmax , QOL had significant difference between two groups before and after treatment(P < 0.05 ) . The change of Ru had no significant difference between two groups before and after treatment ( P > 0.05 ) while there was significant difference between two groups after six-week treatment(P < 0.05 ) . The change of V had no significant difference ( P > 0.05 ) . The adverse reactions in both groups were mild , and there was no significant difference between two groups(P > 0.05 ) . CONCLUSIONS Naftopidil tablet was safe and effective in treating benign prostatic hyperplasia
Although this study did not consider placebo effect and has high IPSS baseline scores , this study clarifies that low-dose tamsulosin has generally positive effect and safety in treatment of LUTS and could be a suitable option as an initial treatment , especially for patients with low body mass index , as is typical of Asian people
PURPOSE In Asian countries , low-dose tamsulosin ( 0.2 mg ) is used widely but this dose has been less popular than 0.4 mg tamsulosin or other types of alpha blockers .
The aim of this study was to investigate the efficacy and safety of low-dose tamsulosin by systematic review and meta- analysis .