Interventions that included ET and PA counseling during PR were effective strategies to improve PA in COPD
BACKGROUND Physical inactivity is associated with poor outcomes in COPD , and as a result , interventions to improve physical activity ( PA ) are a current research focus .
However , many trials have been small and inconclusive .
OBJECTIVE The aim of this systematic review and meta- analysis was to study the effects of r and omized controlled trials ( RCTs ) targeting PA in COPD .
Indacaterol improves lung hyperinflation and physical activity in patients with moderate chronic obstructive pulmonary disease - a randomized, multicenter, double-blind, placebo-controlled study
Background Indacaterol is a long-acting beta-2 agonist for once-daily treatment of COPD . We evaluated the effects of indacaterol 150 μg on lung hyperinflation compared with placebo and open-label tiotropium 18 μg . We measured physical activity during treatment with indacaterol 150 μg and matched placebo . Methods We performed a r and omized , three-period , cross-over study ( 21 days of treatment separated by two wash-out periods of 13 days ) with indacaterol 150 μg or matching placebo and tiotropium 18 μg . Lung function was assessed by body plethysmography and spirometry  . Physical activity was measured for one week by a multisensory armb and at the end of both treatment periods with indacaterol/matched placebo . The primary endpoint was peak inspiratory capacity at the end of each treatment period . Results 129 patients ( mean age , 61 years ; mean post-bronchodilator FEV1 , 64 % ) , were r and omized and 110 patients completed the study . Peak inspiratory capacity was 0.22 L greater with Indacaterol at day 21 compared to placebo ( p < 0.001 ) . Similar results were observed for tiotropium . Both bronchodilators also significantly improved other parameters of lung hyperinflation compared with placebo . All parameters of physical activity were significantly increased during treatment with indacaterol versus placebo . Conclusions Indacaterol 150 μg improved lung hyperinflation in patients with moderate COPD , which was associated with an increase of physical activity . Trial registration Clinical Trials.gov registration number : NCT01012765
Interventions that included ET and PA counseling during PR were effective strategies to improve PA in COPD
BACKGROUND Physical inactivity is associated with poor outcomes in COPD , and as a result , interventions to improve physical activity ( PA ) are a current research focus .
However , many trials have been small and inconclusive .
OBJECTIVE The aim of this systematic review and meta- analysis was to study the effects of r and omized controlled trials ( RCTs ) targeting PA in COPD .