On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Treatment of hyperactive children with monoamine oxidase inhibitors. I. Clinical efficacy.
Fourteen boys ( mean age , 9.2 + /- 1.5 years ) with Attention Deficit Disorder ( ADD ) With Hyperactivity were treated with dextroamphetamine sulfate or a monoamine oxidase inhibitor ( MAOI ) ( six received clorgyline , eight received tranylcypromine sulfate ) for four weeks each in a double-blind , cross-over study that included a two-week placebo washout between active drug periods . The MAOIs had immediate , clinical ly significant benefit and were clinical ly indistinguishable from dextroamphetamine . Most children responded to both stimulant and MAOI . These findings of equivalent efficacy of MAOIs in ADD are in contrast to our previous studies with neurotransmitter system selective agents , which showed only weak effects , and suggest that multiple neurotransmitter alterations may be required for stimulant drug effects in ADD . The immediate response to MAOIs indicates a different mechanism from that mediating antidepressant effect . The MAOIs may be useful alternate treatments in selected cases of ADD
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .