For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .
A double-blind, randomised- placebo, controlled, parallel group, multicentre, flexible-dose escalation study to assess the efficacy and safety of sildenafil administered as required to male outpatients with erectile dysfunction in Korea
The efficacy and safety of sildenafil was evaluated in a r and omiSed , double-blind , placebo-controlled , flexible-dose study in Korean men aged 28–78 y with erectile dysfunction ( ED ) of broad-spectrum aetiology and more than 6 months duration . A total of 133 patients were r and omised at six centres in Korea to receive either sildenafil ( 50 mg initially , increased if necessary to l00 mg or decreased to 25 mg depending on efficacy and tolerance ) ( n=66 ) or matching placebo ( n=67 ) taken on an ‘ as needed ’ basis l h prior to anticipated sexual activity for a period of 8 weeks . At the end of this time , the primary efficacy variables relating to the achievement and maintenance of erections sufficient for sexual intercourse , and the secondary efficacy variables , which included : ( 1 ) the five separate domains of sexual functioning of the International Index of Erectile Function ( IIEF ) scale , ( 2 ) the percentage of successful intercourse attempts , and ( 3 ) a global assessment of erections , were all statistically significantly improved by sildenafil in comparison with placebo ( P<0.0001 ) . Treatment-related adverse events occurred in 56.1 % of patients receiving sildenafil and 20.9 % receiving placebo . The most common adverse events with sildenafil  were vasodilatation ( flushing ) , headache and abnormalities in colour vision ( 31.8 , 22.7 and 6.1 % of patients , respectively ) , and most were mild in nature . The efficacy and safety of sildenafil in this population of Korean men appears similar to that reported in other studies in western population
For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .