There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Plasma fatty-acid composition and antioxidant capacity in low birth-weight infants fed formula enriched with n-6 and n-3 long-chain polyunsaturated fatty acids from purified phospholipids.
OBJECTIVE To determine whether a formula containing n-6 and n-3 long-chain polyunsaturated fatty acids ( LCP ) from purified phospholipids increases the content of 20:4n-6 and 22:6n-3 of plasma lipids and modifies the plasma antioxidant capacity in low-birth-weight infants . STUDY DESIGN Seventeen infants were fed a conventional formula for low birth-weight infants ( F ) , and 17 a formula containing n-6 and n-3 LCP from purified pig-brain phospholipids ( LCP-F ) .  Fourteen infants receiving human milk from a human milk bank were used as a reference ( HM ) . Growth index were measured and blood sample s were taken at entry and after 15 days and 30 days of feeding . RESULTS In infants fed LCP-F the levels of 22:6n-3 in total plasma lipids and in plasma phospholipids and triglycerides were higher than in infants fed F and closer to the levels of HM group throughout the study . Docosahexaenoic acid concentration in total plasma lipids was 3.46+/-0.19 mg/dl in infants fed LCP-F and 2.08+/-0.20 in infants fed F after 15 days of feeding ( P<0.001 ) , and 3.83+/-0.30 and 2.15+/-0.20 in infants fed LCP-F and F respectively , after 30 days of feeding ( P<0.001 ) . The concentration of 20:4n-6 in the LCP-F was significantly higher than in the F group at 15 and 30 days of feeding . Plasma antioxidant capacity did not differ significantly between the study groups . CONCLUSION Feeding low birth-weight infants a formula containing LCP phospholipids results in an increase of n-3 and n-6 LCP in plasma towards that of infants fed human milk
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .