Effects of antihypertensive drugs on SBP variability are dose-dependent and persist when used in combinations .
Use of a high dose of a calcium channel blocker alone or in combination with other agents is therefore likely to be particularly effective in prevention of stroke
BACKGROUND AND PURPOSE Recent studies have shown that visit-to-visit blood pressure variability is a powerful risk factor for stroke , is reduced by calcium channel blockers and diuretics , and increased by β-blockers .
However , it is unknown whether these effects are dose-dependent and persist in combination with other drugs .
The Effect of Trandolapril and Its Fixed-Dose Combination with Verapamil on Circulating Adhesion Molecules Levels in Hypertensive Patients with Type 2 Diabetes
Background and Aim . Endothelial dysfunction in hypertensive type-2 diabetic patients is associated with increased levels of circulating soluble adhesion molecules ( SAM ) . SAM participate in the development of diabetic macroangiopathy and microangiopathy . The aim of this study was to compare the effect of tr and olapril ( T ) and its fixed-dose combination with verapamil ( FDTV ) on SAM levels in hypertensive type-2 diabetic patients . Methods . Forty type-2 diabetic patients with never-treated hypertension were r and omly assigned to two groups . One group ( FDTV ) received 2/180 mg once a day ; the other group received T 2 mg once a day . Study drugs were administered for three months in both groups . VCAM-1 , ICAM , and E-selectin were measured by ELISA at the beginning and end of the study . Patients were evaluated monthly for blood pressure , fasting serum glucose , and adverse events . Statistical analysis was performed with ANOVA . Results . Both therapeutics regimens reduced significantly the levels of the SAM tested . When both groups were compared , we did not find a significant difference in ICAM and E-selectin reduction . However , VCAM-1 presented a significantly greater reduction ( p = 0.022 ) in the tr and olapril-verapamil group . No patient suffered adverse events . Conclusion . Our results show that FDTV produces a greater reduction of VCAM-1 circulating levels than tr and olapril alone . This may explain some of the beneficial effects of this fixed dosed combination that are non-related to its antihypertensive effects
Effects of antihypertensive drugs on SBP variability are dose-dependent and persist when used in combinations .
Use of a high dose of a calcium channel blocker alone or in combination with other agents is therefore likely to be particularly effective in prevention of stroke
BACKGROUND AND PURPOSE Recent studies have shown that visit-to-visit blood pressure variability is a powerful risk factor for stroke , is reduced by calcium channel blockers and diuretics , and increased by β-blockers .
However , it is unknown whether these effects are dose-dependent and persist in combination with other drugs .