Conclusion Our findings may encourage curcumin supplementation based on its meaningful effect on glycemic control and positive trend on lipid outcomes in prediabetes and T2DM
Scope Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus ( T2DM ) .
This study aim ed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM .
Efficacy and Safety of the Dietary Supplement DBCare® in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control
Aims : DBCare ® ( Ace Continental Exports Inc. , London , UK ) is a traditional Indian herbal food supplement marketed as an antidiabetes remedy . This study evaluated the efficacy and safety of DBCare in patients with inadequately controlled type 2 diabetes mellitus ( T2DM ) despite oral hypoglycemic treatment . Methods : A 12-week r and omized double-blind placebo-controlled trial was conducted . Patients with T2DM on oral hypoglycemic agents with HbA1C > 7.0 % were r and omized to receive DBCare or placebo tablets . Results : Thirty-five patients ( 20 male/15 female ; mean age 61.2 ± 7.6 years ) , with a mean baseline HbA1C of 7.9 % ± 0.6 % , received DBCare ( N = 18 ) or placebo ( N = 17 ) . During the study period , HbA1C declined 0.4 ± 0.7 % in the DBCare ® group and 0.2 % ± 0.8 % in the placebo group ( p = 0.806 ) . No significant changes occurred in fasting plasma glucose , lipid profile , or homeostasis model assessment throughout the study or in body mass index , waist circumference , or blood pressure values . Hypoglycemic episodes ( glucose < 70 mg/dL ) were more frequent in the treatment group ( 7 vs 1 , p = 0.043 ) , necessitating a decrease in other hypoglycemic medications in 2 patients . DBCare was generally well tolerated , with mild side effects that were not different from those of the placebo group . Conclusions : This preliminary study did not demonstrate that DBCare was efficacious in improving glycemic control in inadequately controlled patients with T2DM on oral hypoglycemics . A trend toward improved glycemic control was noted in the DBCare group , which correlates with more frequent hypoglycemic episodes . Further studies are needed to eluci date DBCare 's hypoglycemic effect in patients with T2DM in general and in specific clinical setting s , such as HbA1C ≥ 8 % , short ( ≤10-year ) duration of diabetes , or young age in particular
Conclusion Our findings may encourage curcumin supplementation based on its meaningful effect on glycemic control and positive trend on lipid outcomes in prediabetes and T2DM
Scope Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus ( T2DM ) .
This study aim ed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM .