A similar effect has been found in chronic pelvic inflammatory disease .
The review also revealed that  balneotherapy has some beneficial effects on antioxidant status , and on metabolic and inflammatory parameters .
Based on the results , we conclude that balneotherapy with Hungarian thermal-mineral waters is an effective remedy for  lower back pain  , as well as for knee and h and osteoarthritis
Balneotherapy is appreciated as a traditional treatment modality in medicine .
Hungary is rich in thermal mineral waters .
Balneotherapy has been in extensive use for centuries and its effects have been studied in detail .
No significant change of plasma beta-endorphin levels of psoriasis patients after synchronous balneophototherapy.
BACKGROUND / PURPOSE Previous studies suggested that beta-endorphin has a pathogenic role in psoriasis : its increased plasma concentration may play a role in the neuroimmunological processes in the pathomechanism of the disease , and plasma beta-endorphin levels should reflect the changes in the patients ' skin status . The purpose of this study was to investigate the changes of peripheral blood beta-endorphin levels in psoriatic patients in conjunction with changes in their skin symptoms after synchronous balneophototherapy .  METHODS With synchronous balneophototherapy , 12 patients with extended skin symptoms of psoriasis were treated . The therapy followed the Regensburg protocol , consisting of a basic course of 35 sessions . Patients ' skin status was characterized by evaluating the Psoriasis Area and Severity Index score before and after the therapy course . Blood sample s were taken before treatment , and 1 day after the last session , with symptom-free skin . Plasma beta-endorphin levels were measured by a specific radioimmunoassay developed by the authors . RESULTS There was no significant change in plasma levels of beta-endorphin after clinical clearance of psoriatic skin symptoms . CONCLUSION In this non-r and omized , uncontrolled study no significant difference could be detected between plasma beta-endorphin levels before and after a basic course of synchronous balneophototherapy in patients with psoriasis . Although beta-endorphin has many neuroimmunological effects , the changes of its plasma level do not consistently reflect the skin status . Inflammation in psoriatic skin lesions is probably not mediated directly by circulating beta-endorphin
A similar effect has been found in chronic pelvic inflammatory disease .
The review also revealed that  balneotherapy has some beneficial effects on antioxidant status , and on metabolic and inflammatory parameters .
Based on the results , we conclude that balneotherapy with Hungarian thermal-mineral waters is an effective remedy for  lower back pain  , as well as for knee and h and osteoarthritis
Balneotherapy is appreciated as a traditional treatment modality in medicine .
Hungary is rich in thermal mineral waters .
Balneotherapy has been in extensive use for centuries and its effects have been studied in detail .