Perioperative risk factors were inconsistently associated with developmental outcomes .
INTERPRETATION The literature on children undergoing surgery in early infancy suggests that infants with a single ventricle are at highest risk of adverse developmental outcomes .
WHAT THIS PAPER ADDS Children with complex congenital heart disease ( CHD ) are at increased risk of impaired developmental outcome .
Children with single-ventricle CHD have worse outcomes than children with two-ventricle CHD .
Children with two-ventricle CHD gradually grow out of their initial developmental impairment .
Perioperative factors are inconsistently associated with outcome
AIM ( 1 ) To systematic ally review the literature on developmental outcomes from infancy to adolescence of children with complex congenital heart disease ( CHD ) who underwent early surgery ; ( 2 ) to run a meta-regression analysis on the Bayley Scales of Infant Development , Second Edition Mental Developmental Index and Psychomotor Developmental Index ( PDI ) of infants up to 24 months and IQs of preschool-aged children to adolescents ; ( 3 ) to assess associations between perioperative risk factors and outcomes .
Impact of prenatal diagnosis on neurocognitive outcomes in children with transposition of the great arteries.
OBJECTIVES To assess the effect of prenatal diagnosis of congenital heart disease on neurocognitive outcomes in children with d-transposition of the great arteries ( TGA ) after surgical correction . STUDY DESIGN A prospect i ve study of children born with a TGA between 2003 and 2005 and aged 4 to 6 years was conducted . General intelligence , language , executive functions , and social cognition scores and preoperative , intraoperative , and postoperative factors were evaluated according to time of TGA diagnosis . Neurocognitive data were also compared with a control group . RESULTS Forty-five eligible patients ( 67 % male ) were examined ; 29 had a prenatal diagnosis of TGA and 16 did not . All children were comparable in age , sex , and demographic variables . Diagnostic groups did not differ in preoperative , intraoperative , and postoperative variables . Preoperative acidosis was more frequent in the postnatal group ( 18 % versus 3 % ) . All patients had normal IQ scores , language , and verbal working memory . However , neurocognitive deficits were more prevalent and more severe in children with a postnatal-TGA . Prenatal diagnosis was associated with better outcomes in executive functions . CONCLUSIONS Prenatal diagnosis of TGA is associated with better neurocognitive outcomes . Time of diagnosis may influence the development of early complex cognitive skills such as executive functions
Perioperative risk factors were inconsistently associated with developmental outcomes .
INTERPRETATION The literature on children undergoing surgery in early infancy suggests that infants with a single ventricle are at highest risk of adverse developmental outcomes .
WHAT THIS PAPER ADDS Children with complex congenital heart disease ( CHD ) are at increased risk of impaired developmental outcome .
Children with single-ventricle CHD have worse outcomes than children with two-ventricle CHD .
Children with two-ventricle CHD gradually grow out of their initial developmental impairment .
Perioperative factors are inconsistently associated with outcome
AIM ( 1 ) To systematic ally review the literature on developmental outcomes from infancy to adolescence of children with complex congenital heart disease ( CHD ) who underwent early surgery ; ( 2 ) to run a meta-regression analysis on the Bayley Scales of Infant Development , Second Edition Mental Developmental Index and Psychomotor Developmental Index ( PDI ) of infants up to 24 months and IQs of preschool-aged children to adolescents ; ( 3 ) to assess associations between perioperative risk factors and outcomes .