The conversion of dialysis patients to a vitamin E-coated dialyser is associated with an improvement in circulating biomarkers of lipid peroxidation , which is of potential clinical benefit
BACKGROUND Oxidative stress is prevalent in dialysis patients and has been implicated in the pathogenesis of cardiovascular disease and anaemia .
We conducted a systematic review and meta- analysis to examine the effect of Excebrane , a vitamin E-coated cellulose-based dialyser , on circulating biomarkers of lipid peroxidation , as surrogate markers of oxidative stress .
Vitamin E-bonded hemodialyzer improves neutrophil function and oxidative stress in patients with end-stage renal failure.
We evaluated the biocompatibility of a newly developed vitamin E hemodialyzer ( CL-EE ; Terumo Co Ltd , Tokyo , Japan ) by neutrophil function and oxidant stress in patients with end-stage renal failure in a r and omized crossover study . Ten patients underwent hemodialysis using either the CL-EE  or a control dialyzer membrane identical to the CL-EE except for vitamin E binding for 12 weeks in a crossover fashion after a 1-month washout period with hemophane membranes . White blood cell counts , serum oxidized low-density lipoprotein ( Ox-LDL ) levels , and malondialdehyde ( MDA ) levels during hemodialysis sessions were measured at the initiation and end of the CL-EE and control trials . Superoxide anion production by neutrophils just before and 4 hours after starting the session also was measured . Leukocytopenia at 1 hour after starting the session was detected to a similar extent in both membranes . However , the degree of reduction was less in the CL-EE trial after repeated use . Superoxide anion production by neutrophils just before a hemodialysis session was reduced after repeated use of the CL-EE membrane .  Serum Ox-LDL levels increased , whereas serum MDA levels decreased during sessions to a similar extent in both trials . However , these parameters were significantly lower in the CL-EE trial after repeated use . Serum LDL concentrations significantly decreased with repeated use of the CL-EE membrane . These data suggest that repeated use of the CL-EE membrane for 3 months improves neutrophil function , oxidant stress , and LDL concentrations in patients with renal failure . This membrane may be useful to reduce the incidence of cardiovascular events in patients with renal failure
The conversion of dialysis patients to a vitamin E-coated dialyser is associated with an improvement in circulating biomarkers of lipid peroxidation , which is of potential clinical benefit
BACKGROUND Oxidative stress is prevalent in dialysis patients and has been implicated in the pathogenesis of cardiovascular disease and anaemia .
We conducted a systematic review and meta- analysis to examine the effect of Excebrane , a vitamin E-coated cellulose-based dialyser , on circulating biomarkers of lipid peroxidation , as surrogate markers of oxidative stress .