Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .
Conjugated linoleic acids reduce body fat in healthy postmenopausal women.
Isomers of conjugated linoleic acids ( CLA ) reduce fat mass ( FM ) and increase insulin sensitivity in some , but not all , murine studies . In humans , this effect is still debatable . In this study , we compared the effect of 2 CLA supplements on total and regional FM assessed by dual energy X-ray absorptiometry , changes in serum insulin and glucose concentrations , and adipose tissue ( AT ) gene expression in humans . In a double-blind , parallel , 16-wk intervention , we r and omized 81 healthy postmenopausal women to 1 ) 5.5 g/d of 40/40 % of cis9,trans11-CLA ( c9,t11-CLA ) and trans10,cis12-CLA ( t10,c12-CLA ) ( CLA-mix ) ; 2 ) cis9 , trans11-CLA ( c9,t11-CLA ) ; or 3 ) control ( olive oil ) .  We assessed all variables before and after the intervention . The CLA-mix group had less total FM ( 4 % ) and lower-body FM ( 7 % ) than the control ( P = 0.02 and < 0.001 , respectively ) . Post hoc analyses showed that serum insulin concentrations were greater in the CLA-mix group ( 34 % ) than the control group ( P = 0.02 ) in the highest waist circumference tertile only . AT mRNA expression of glucose transporter 4 , leptin , and lipoprotein lipase was lower , whereas expression of tumor necrosis factor-alpha was higher in the CLA-mix group than in the control group ( P < 0.04 ) . In conclusion , a 50:50 mixture of c9,t11- and t10,c12-CLA isomers result ed in less total and lower-body FM  in postmenopausal women and greater serum insulin concentrations in the highest waist circumference tertile . Future research is needed to confirm the insulin desensitizing effect of the CLA mixture and the effect on the mRNA expression of adipocyte-specific genes in humans
Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .