The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .
Beneficial Effects on Arterial Stiffness and Pulse-Wave Reflection of Combined Enalapril and Candesartan in Chronic Kidney Disease - A Randomized Trial
Background Cardiovascular disease ( CVD ) is highly prevalent in patients with chronic kidney disease ( CKD ) . Inhibition of the renin-angiotensinsystem ( RAS ) in hypertension causes differential effects on central and brachial blood pressure ( BP ) , which has been translated into improved outcome . The objective was to examine if a more complete inhibition of RAS by combining an angiotensin converting enzyme inhibitor ( ACEI ) and an angiotensin receptor antagonist ( ARB ) compared to monotherapy has an additive effect on central BP and pulse-wave velocity ( PWV ) , which are known markers of CVD . Methods Sixty-seven CKD patients ( mean GFR 30 , range 13–59 ml/min/1.73 m2 ) participated in an open r and omized study of 16 weeks of monotherapy with either enalapril or c and esartan followed by 8 weeks of dual blockade aim ing at a total dose of 16 mg c and esartan and 20 mg enalapril o.d . Pulse-wave measurements were performed at week 0 , 8 , 16 and 24 by the SphygmoCor device . Results Significant additive BP independent reductions were found after dual blockade in aortic PWV ( −0.3 m/s , P<0.05 ) and in augmentation index ( −2 % , P<0.01 ) compared to monotherapy . Furthermore pulse pressure amplification was improved ( P<0.05 ) and central systolic BP reduced ( −6 mmHg , P<0.01 ) . Conclusions Dual blockade of the RAS result ed in an additive BP independent reduction in pulse-wave reflection and arterial stiffness compared to monotherapy in CKD patients . Trial Registration Clinical trial.gov
The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .