The systematic review revealed widespread utilization of developmentally appropriate QL instruments but less frequent use of both self and proxy reports and an inconsistent approach to age group specificities .
Research on the quality of life ( QL ) of children/adolescents with psychological disorders has flourished over the last few decades .
Given the developmental challenges of QL measurements in pediatric population s , the aim of this study was to ascertain the extent to which a developmental approach to  QL assessment has been applied to pedopsychiatric QL research .
Randomized controlled pilot study of quetiapine in the treatment of adolescent conduct disorder.
OBJECTIVE The aim of this study was to examine whether quetiapine is superior to placebo in the treatment of adolescents with conduct disorder . METHODS This was a 7-week , r and omized , double-blind , placebo-controlled pilot study with two parallel arms . Nine youths were r and omly assigned to receive quetiapine , and 10 youths were r and omly assigned to receive placebo .  Patients were assessed weekly throughout the trial . Quetiapine was dosed twice daily , and medications could be titrated flexibly through the end of study week 5 . The dose was fixed for the final 2 weeks of the study . The primary outcome measures were the clinician-assessed Clinical Global Impressions-Severity ( CGI-S ) and -Improvement ( CGI-I ) scales . Secondary outcome measures included parent-assessed quality of life , the overt aggression scale ( OAS ) , and the conduct problems subscale of the Conners ' Parent Rating Scale ( CPRS-CP ) . RESULTS The final mean dose of quetiapine was 294 + /- 78 mg/day ( range 200 - 600 mg/day ) . Quetiapine was superior to placebo on all clinician-assessed measures and on the parent-assessed quality of life rating scale . No differences were found on the parent-completed OAS and CPRS-CP .  Quetiapine was well tolerated . One patient r and omized to quetiapine developed akathisia , requiring medication discontinuation . No other extrapyramidal side effects occurred in patients receiving active drug . CONCLUSIONS This method ologically controlled pilot study provides data that quetiapine may have efficacy in the treatment of adolescents with conduct disorder . Because of the preliminary nature of the study , further research with larger sample s is needed to confirm these findings
The systematic review revealed widespread utilization of developmentally appropriate QL instruments but less frequent use of both self and proxy reports and an inconsistent approach to age group specificities .
Research on the quality of life ( QL ) of children/adolescents with psychological disorders has flourished over the last few decades .
Given the developmental challenges of QL measurements in pediatric population s , the aim of this study was to ascertain the extent to which a developmental approach to  QL assessment has been applied to pedopsychiatric QL research .