The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Brazilian multicenter study on efficacy and tolerability of trandolapril in mild-to-moderate essential arterial hypertension. EMBATHE substudy with ambulatory blood pressure monitoring.
OBJECTIVE A double-blind , placebo-controlled multicenter study involving 34 centers from different Brazilian regions was performed to evaluate the antihypertensive efficacy and tolerability of tr and olapril , an angiotensin I converting enzyme inhibitor , in the treatment of mild-to-moderate systemic arterial hypertension . METHODS Of 262 patients enrolled in this study , 127 were treated with tr and olapril 2 mg/day for 8 consecutive weeks , and the remaining 135 patients received placebo  for the same period of time . Reduction in blood pressure ( BP ) and the occurrence of adverse events during this period were evaluated in both groups . RESULTS Significantly reductions in both systolic and diastolic pressures were observed in patients treated with tr and olapril when compared with those on placebo .  Antihypertensive efficacy was achieved in 57.5 % of the patients on tr and olapril and in 42 % of these normal values of BP were obtained . The efficacy of tr and olapril was similar in all centers , regardless of the area of the country . In a subset of 30 patients who underwent ABPM , responders showed a significant hypotensive effect to tr and olapril throughout the 24 hour day . The adverse event profile was similar in both tr and olapril and placebo groups . CONCLUSION Our results demonstrate , for the first time in a large group of hypertensive patients from different regions in Brazil , good efficacy and tolerability of tr and o-lapril during treatment of mild-to-moderate essential systemic hypertension
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .