For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .
Treatment of erectile dysfunction in men with depressive symptoms: results of a placebo-controlled trial with sildenafil citrate.
OBJECTIVE Depressed men commonly have erectile dysfunction , and men with erectile dysfunction are frequently depressed . Since the etiologic and modulatory relationships between depression and erectile dysfunction have been poorly characterized , a 12-week , r and omized , double-blind , placebo-controlled trial was conducted at 20 urologic clinics to evaluate the effects of sildenafil treatment in men with erectile dysfunction and mild-to-moderate comorbid depressive illness . METHOD Men ( N=152 , mean age=56 years ) with erectile dysfunction for > or = 6 months ( mean=5.7 years ) , a DSM-IV diagnosis of depressive disorder not otherwise specified , and a Hamilton Depression Rating Scale score > or = 12 ( mean at baseline=16.9 ) were r and omly assigned to flexible-dose treatment with sildenafil citrate or matching placebo . Interviewer-rated and self-report instruments were used to assess changes in sexual function , depressive symptoms , and quality of life . Conservative criteria were used to classify erectile dysfunction treatment response and nonresponse . RESULTS Sildenafil was strongly associated with erectile dysfunction treatment response .  Fifty-eight men met the conservative criteria for response ( 48 given sildenafil , 10 given placebo ) , and 78 men did not respond ( 18 given sildenafil , 60 given placebo ) . Mean decreases of 10.6 and 2.3 in Hamilton depression scale scores were seen in treatment responders and nonresponders , respectively ; 76 % of treatment responders showed a > or = 50 % decline in Hamilton depression scale score versus 14 % of nonresponders . Quality of life was similarly improved in treatment responders . CONCLUSIONS Sildenafil is efficacious for erectile dysfunction in men with mild-to-moderate depressive illness . Improvement of erectile dysfunction is associated with marked improvement in depressive symptoms and quality of life
For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .