Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .
Vitamin D attenuates pro-inflammatory TNF-α cytokine expression by inhibiting NF-кB/p65 signaling in hypertrophied rat hearts
A growing body of evidence suggests that immune activation and inflammatory mediators may play a key role in the development and progression of left ventricle ( LV ) hypertrophy . The present study was design ed to test the hypothesis that the cardioprotective effect of cholecalciferol ( Vit-D3 ) is mediated via the regulation of messenger RNA ( mRNA ) expression of pro-inflammatory cytokines . Rats were r and omly divided into four groups : control group received normal saline ( 0.9 % NaCl ) i.p . for 14 days ; Vit-D3 group received Vit-D3 at a dose of 12 μg/kg/day by gavage for 14 days ; ISO group received saline for 7 days , and at day 7 , ISO ( 5 mg/kg/day ) was injected i.p . for 7 consecutive days to induce cardiac hypertrophy ; and Vit-D3 + ISO group was treated with Vit-D3 for 14 days , and at day 7 , ISO was administered for 7 consecutive days . Heart/body weight ratio , troponin-T , creatine kinase-MB , and tumor necrosis factor-α ( TNF-α ) levels of LV tissue were estimated . Levels of mRNA expression of NF-кB (NF-кB)/p65 and inhibitory kappa B (IкB)-α were determined by real-time PCR . Vit-D3 administration before and during induction of cardiac hypertrophy significantly reduced ( P < 0.001 ) cardiac biomarkers . The histopathological examination further confirmed these results . In addition , Vit-D3 significantly decreased ( P < 0.001 ) NF-кB-p65 mRNA expression and increased ( P < 0.01 ) IкB-α mRNA expression in LV tissues compared to ISO group . Based on these findings , it was concluded that the administration of cholecalciferol markedly attenuated the development of ISO-induced cardiac hypertrophy likely through downregulation of TNF-α /NF-кb/p65 signaling pathways . However , it should be pointed out that other signaling pathways may contribute to the cardioprotective effect of Vit-D3 which requires further investigation
Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .