They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .
Combination of bolus dose vitamin D with routine vaccination in infants: a randomised trial.
INTRODUCTION The present study was design ed to compare two methods of vitamin D supplementation in infants : every two months as a routine vaccination versus a daily dose . METHODS A r and omised clinical trial was performed on 120 healthy breastfed infants between January and September 2007 in Yazd , Iran . The infants were r and omly divided into three groups with different doses of vitamin D3 supplementation : 200 IU daily , 400 IU daily and a bolus of 50,000 IU every two months . A blood sample was taken and evaluated for 25-hydroxy vitamin D and calcium levels when the infants were six months old . The data was reported as the mean and st and ard deviation . RESULTS No significant differences were observed between the serum level of 25-hydroxy vitamin D in the groups administered with 200 IU and 400 IU vitamin D daily . However , the serum level of 25-hydroxy vitamin D reached significance in the third group ( p is less than 0.001 ) . All the blood calcium measured was below 11 mg/dl in the bolus group . A few complications such as diarrhoea and agitation , all of which were self-limited , were seen in the bolus group . No other significant side effects were reported in the other groups . CONCLUSION This study demonstrates that a bolus of 50,000 IU of vitamin D every two months with a routine child vaccination program provides the ideal serum level of vitamin D. This method produces no serious side effects and offers a highly convenient way to supply vitamin D , especially among non-compliant parents
They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .