In regards to surgery it is recommended to perform total omentectomy since subclinic metastasis have been documented in 10 - 30 % of all cases , and systematic limphadenectomy , necessary to be able to obtain an adequate surgical staging .
Minimal invasion surgery is not a recommended procedure for the treatment of advanced ovarian cancer .
Radiotherapy can be used to palliate symptoms .
In the present , there is not a st and ardized screening method .
Diagnosis in early stages means a better survival .
Radiotherapy can be indicated to palliate symptoms
INTRODUCTION Ovarian cancer ( OC ) is the third most common gynecologic malignancy worldwide .
Most of cases it is of epithelial origin .
At the present time there is not a st and ardized screening method , which makes difficult the early diagnosis .
The 5-year survival is 90 % for early stages , however most cases present at advanced stages , which have a 5-year survival of only 5 - 20 % .
GICOM collaborative group , under the auspice of different institutions , have made the following consensus in order to make recommendations for the diagnosis and management regarding to this neoplasia .
Until now , laparoscopy for diagnostic-staging surgery is not well known as a recommended method .
In advanced stages , primary cytoreduction is recommended as initial treatment .
Protracted oral etoposide in epithelial ovarian cancer: a phase II study in patients with relapsed or platinum-resistant disease.
This phase II study evaluates the efficacy and toxicity of a prolonged schedule of oral etoposide in patients with measurable advanced ovarian cancer resistant to , or relapsed following , platinum-based chemotherapy . Forty-seven patients participated , 20 of whom had received more than one prior treatment . Seventy-seven per cent had evidence of disease progression during or within 6 months of the previous chemotherapy . Initially , oral etoposide , 50 mg b.d . ( regardless of patient size ) , was given for 14 days on a 21-day cycle . However , after encountering toxicity , the schedule was modified to 7 days ' treatment escalating to 10 then 14 days if well tolerated . Among 41 assessable patients there were two complete and eight partial objective responses ( 24 % response rate ; 95 % confidence interval 12 - 41 % ) . Nine further patients ( 22 % ) had stable disease , four with a sustained fall of > 50 % in CA-125 . Median duration of response or stable disease was 35 weeks ( range 21 - 49 ) . Overall median survival was 41 weeks from study entry ( range 2 to 96 + weeks ) . Toxicity for most patients was mild , but sporadic severe myelotoxicity occurred , with two treatment-related deaths . Risk factors for severe toxicity were : performance status 3 ; hepatic impairment ; renal impairment . We conclude that oral etoposide has activity in platinum-resistant ovarian cancer and that it is a useful palliative therapy . It has significant toxicity which may be avoided by appropriate patient selection and an escalating- duration schedule
In regards to surgery it is recommended to perform total omentectomy since subclinic metastasis have been documented in 10 - 30 % of all cases , and systematic limphadenectomy , necessary to be able to obtain an adequate surgical staging .
Minimal invasion surgery is not a recommended procedure for the treatment of advanced ovarian cancer .
Radiotherapy can be used to palliate symptoms .
In the present , there is not a st and ardized screening method .
Diagnosis in early stages means a better survival .
Radiotherapy can be indicated to palliate symptoms
INTRODUCTION Ovarian cancer ( OC ) is the third most common gynecologic malignancy worldwide .
Most of cases it is of epithelial origin .
At the present time there is not a st and ardized screening method , which makes difficult the early diagnosis .
The 5-year survival is 90 % for early stages , however most cases present at advanced stages , which have a 5-year survival of only 5 - 20 % .
GICOM collaborative group , under the auspice of different institutions , have made the following consensus in order to make recommendations for the diagnosis and management regarding to this neoplasia .
Until now , laparoscopy for diagnostic-staging surgery is not well known as a recommended method .
In advanced stages , primary cytoreduction is recommended as initial treatment .