Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .
[Efficacy of standardized isoflavones extract (Soyfem) (52-104 mg/24h) in moderate and medium-severe climacteric syndrome].
INTRODUCTION In recent years , considerable attention has been paid to isoflavones and their proprieties to alleviate the climacteric symptoms . The goal of this study was to evaluate the efficacy of st and ardized isoflavones extract ( Soyfem ) in moderate and medium-severe  climacteric syndrome .  MATERIAL AND METHODS 555 postmenopausal women were recruited for the study . Out of this group , 169 women completed the study ( 12-month observation period ) . The patients were classified according to the intensity of climacteric symptoms ( < or = 34 points in Kupperman index ) . 1 or 2 tablets of Soyfem were administered twice a day . RESULTS A regular decrease of Kupperman index value and improvement of life quality were observed in the group of 169 postmenopausal women . We have noted a decrease in the intensity and number of hot flushes , diaphoresis ( p < 0.05 ) , diminished sleep disturbances ( p < 0.05 ) , decreased headache , dizziness , and arthrosis pain . The diminished intensity of tiredness , palpitation and breathlessness have been also observed ( p < 0.05 ) . 80 % of all investigated women noted the regression of paresthesis , 20 % indicated the decreased number of paresthesis ( p < 0.05 ) . Influence of Soyfem on the variability and moderation of depressive mood ( p < 0.05 ) have been also positive evaluated by patients . CONCLUSIONS Administration of Soyfem in the dosage 52 to 104 mg/24 hours ( 2 times daily 1 or 2 tablets ) is a safe and effective therapy in the postmenopausal women with moderate and medium-severe climacteric syndrome evaluated according to the Kupperman index . Administration of Soyfem is connected with a good compliance and correlated with well-being in the investigated women allowing a long-term administration
Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .