Studies reported that Serenoa repens was effective in relieving lower urinary tract symptoms ( LUTS ) .
This study indicated that Serenoa repens had the same effect in treating BPH compared with tamsulosin in terms of IPSS , QoL , and PVR after at least 6-month treatment cycle , however , the latter had a greater improvement in PV compared with the former .
And Serenoa repens did not increase the risk of adverse events especially with respect to ejaculation disorders and libido decrease
Long-term clinical and biologic effects of the lipidosterolic extract of Serenoa repens in patients with symptomatic benign prostatic hyperplasia.
Permixon , the lipidosterolic extract of Serenoa repens , is widely used for the treatment of symptoms associated with benign prostatic hyperplasia ( BPH ) . This open study assessed the efficacy and tolerability of Permixon 160 mg twice daily administered for 2 years . One hundred fifty-five men with clinical ly diagnosed BPH and complaints of prostatic symptoms were enrolled in the study . At 6 , 12 , 18 , and 24 months , the International Prostate Symptom Score ( I-PSS ) , quality of life , and sexual function score were recorded , and urodynamics and biologic values were measured . Adverse events were recorded every 3 months . I-PSS and quality of life improved significantly from baseline at each evaluation time point . At the end of the study and at each evaluation , maximum urinary flow also improved significantly . Prostate size decreased . Sexual function remained stable during the first year of treatment and significantly improved ( P = .001 ) during the second year . Prostate-specific antigen was not affected , and no changes in plasma hormone levels were observed . Nine patients reported 10  adverse events  , none related to treatment . Improvements in efficacy parameters began at 6 months and were maintained up to 24 months . These data demonstrate the long-term efficacy and tolerability of Permixon and support its use as a first-line medical therapy for uncomplicated symptomatic BPH
Studies reported that Serenoa repens was effective in relieving lower urinary tract symptoms ( LUTS ) .
This study indicated that Serenoa repens had the same effect in treating BPH compared with tamsulosin in terms of IPSS , QoL , and PVR after at least 6-month treatment cycle , however , the latter had a greater improvement in PV compared with the former .
And Serenoa repens did not increase the risk of adverse events especially with respect to ejaculation disorders and libido decrease