Levels of other adipocytokines were not significantly affected .
CONCLUSION Eicosapentaenoic acid and docosahexaenoic acid supplementation may increase adiponectin and reduce TNF-α levels in this population group .
BACKGROUND The objective of this systematic review and meta- analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals .
Biological Effects of Add-On Eicosapentaenoic Acid Supplementation in Diabetes Mellitus and Co-Morbid Depression: A Randomized Controlled Trial
Background Eicosapentaenoic acid ( EPA ) may reduce increased risks for ( cardiovascular ) morbidity and mortality in patients with diabetes mellitus ( DM ) and comorbid major depressive depression ( MDD ) . Yet , effects of EPA-supplementation on biological risk factors for adverse outcomes have not been studied in DM- patients with MDD . Methods We performed a r and omized , double-blind trial ( n = 25 ) comparing add-on ethyl-EPA-supplementation to placebo on ( I ) oxidative stress , ( II ) inflammatory , ( III ) hypothalamic-pituitary-adrenal (HPA)-axis , ( IV ) one-carbon-cycle , ( V ) fatty acid metabolism and ( VI ) lipoprotein parameters during 12-weeks ' follow-up . Results Besides increases in supplemented α-tocopherol [ estimate ( 95 % CI ) ; 3.62 ( 1.14–6.11 ) µmol/l ; p = 0.006 ] and plasma and erythrocyte EPA , the intervention did not influence other oxidative stress , inflammatory or one-carbon-cycle parameters compared to placebo . HPA-axis reactivity significantly decreased in the EPA-group ( N = 12 ) [ AUCi : −121.93 ( −240.20–−3.47 ) min × nmol/l ; p = 0.045 ] , not in the placebo-group ( N = 12 ) . Furthermore , EPA-supplementation increased erythrocyte and plasma docosapentaenoic acid , and decreased plasma arachidonic acid ( AA ) concentrations [ −1.61 ( −3.10–−0.11 ) % ; p = 0.036 ] . Finally , EPA had a multivariate influence on lipoprotein concentrations ( p = 0.030 ) , reflected by relative increases in high density lipoprotein [ HDL ; 0.30 ( 0.02–0.58 ) mmol/l ; p = 0.039 ] and total cholesterol concentrations [ 1.01 ( 0.29–1.72 ) mmol/l ; p = 0.008 ] . Conclusion Overall , add-on EPA-supplementation had limited effects on biological risk factors for adverse outcome in this sample of DM- patients with comorbid MDD . Besides increases in concentrations of supplemented α-tocopherol and EPA , AA decreased , and inconclusive effects on HPA-axis (re)activity and lipoprotein concentrations were observed . Therefore , further studies on the alleged beneficial effects of EPA-supplementation on biological risk factors for adverse outcome in DM- patients with comorbid MDD seem warranted , preferably using clinical outcomes such as ( cardiovascular ) DM-complications . Trial Registration Controlled-Trials.com IS RCT N30877831 IS RCT
Levels of other adipocytokines were not significantly affected .
CONCLUSION Eicosapentaenoic acid and docosahexaenoic acid supplementation may increase adiponectin and reduce TNF-α levels in this population group .
BACKGROUND The objective of this systematic review and meta- analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals .