This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .
Preoperative Parenteral Parecoxib and Follow-Up Oral Valdecoxib Reduce Length of Stay and Improve Quality of Patient Recovery After Laparoscopic Cholecystectomy Surgery
In this r and omized , double-blinded , placebo-controlled study , we evaluated the effects of preoperative IV parecoxib sodium ( parecoxib ) followed by postoperative oral valdecoxib on length of stay , re source utilization , opioid-related side effects , and patient recovery after elective laparoscopic cholecystectomy . Patients were r and omized to receive a single IV dose of parecoxib 40 mg ( n = 134 )  or placebo  ( n = 129 ) 30–45 min before the induction of anesthesia . Six to 12 h after the IV dose , the parecoxib group received a single oral dose of valdecoxib 40 mg , followed by valdecoxib 40 mg once daily on postoperative Days 1–4 and then 40 mg once daily as needed on Days 5–7 . Patients in the parecoxib/valdecoxib group had a shorter length of stay in the postanesthesia care unit ( 78 ± 47 min ) compared with those taking placebo ( 90 ± 49 min ; P < 0.05 ) . Patients in the parecoxib/valdecoxib group also had reduced pain intensity and , after discharge , experienced a significant reduction in vomiting in the first 24 h , slept better , returned to normal activity earlier , and expressed greater satisfaction than placebo patients ( P < 0.05 ) . Preoperative parecoxib followed by postoperative valdecoxib is a valuable adjunct for treating pain and improving patient outcome after laparoscopic cholecystectomy
This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .