The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .
Systemic inflammatory responses during laparoscopic and open inguinal hernia repair: a randomised prospective study.
OBJECTIVE To see if the inflammatory responses during and after laparoscopic and open inguinal hernia repairs differed . DESIGN R and omised prospect i ve study . SETTING County hospital , Denmark . PATIENTS 18 men aged 25 - 77 years with unilateral inguinal hernias . INTERVENTIONS Ten patients had a laparoscopic repair and 8 an open tension-free repair .  MAIN OUTCOME MEASURES Serum concentrations of interleukin (IL)-2 receptors ( R ) of the alpha group ( IL-2Ralpha ) , IL-6 , anti-IL-6 , IL-10 , tumour necrosis factor (TNF)-alpha , sTNF-RI and sTNF-RII before and 2 , 6 , 12 , and 24 hours after the repairs . Duration of operation and time for return to normal activities or work were also recorded . RESULTS Serum IL-6 concentrations increased significantly after operation in both groups ( p < 0.0001 ) , but the increase was significantly higher after open than after laparoscopic surgery at all sampling times ( p = 0.00 ) at 6 hours postoperatively ) . Anti-IL-6 and IL-10 remained undetectable at all time points . There were no significant differences or increases in the concentrations of TNF-alpha or sTNF-RII . However , sTNF-RI concentrations increased significantly in both groups ( p < 0.001 ) though there was no difference in between the two groups . IL-2Ralpha decreased significantly in both groups ( p < 0.01 ) with no differences between the groups . The median operation time was 85 min ( range 55 - 100 min ) in the laparoscopic group and 52 min ( range 45 - 79 min ) in the " open " group ( p < 0.01 ) . Median time to return to normal activities/work were 2 and 13 days after laparoscopic and open operations , respectively ( p < 0.01 ) . CONCLUSION The surgical trauma of laparoscopic inguinal hernia repair is less than that of open tension-free hernia operations as assessed by circulating mediators of the postoperative inflammatory response . The clinical relevance of this finding must be evaluated in larger r and omised studies
The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .