In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .
Prospective randomized trial of paclitaxel alone versus 5-fluorouracil/doxorubicin/cyclophosphamide as induction therapy in patients with operable breast cancer.
The objective of this study was to compare the antitumor activity of single-agent paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) with that of the 5-fluorouracil/doxorubicin/cyclophosphamide ( FAC ) combination by evaluating the extent of residual disease in the breast and regional lymph nodes of patients with breast cancer following four cycles of induction chemotherapy .  Patients with histologically confirmed invasive but noninflammatory carcinoma of the breast stages T2 - 3 , N0 - 1 , M0 were eligible to enter the study . Patients were treated with four cycles of either FAC or single-agent paclitaxel before local therapy . Following local therapy , treatment of the two arms was identical . Of 104 operable breast cancer patients who were treated with either regimen , 78 were evaluable for response to preoperative chemotherapy and had undergone local therapy . Age , TNM classification , and estrogen receptor status of the patients were similar in the two groups . Following induction chemotherapy , the extent of disease in the breast and the distribution and number of positive nodes were similar between the two treatment arms . Disease progressed in two patients in the FAC arm and in none in the paclitaxel arm during the induction phase of therapy . A higher fraction of patients had neutropenic fever during the paclitaxel treatment . Initial data from this ongoing r and omized study show that paclitaxel alone has comparable anticancer activity with FAC in patients with early breast cancer . The degree of cytoreduction was similar with both induction therapies
In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .