No significant changes were observed for blood lipids , anthropometric measures , HbA1c and fasting glucose .
The present systematic review provides evidence for beneficial effects of long-term interventions administering a low glycemic index/load diet with respect to fasting insulin and pro-inflammatory markers such as C-reactive protein which might prove to be helpful in the primary prevention of obesity-associated diseases
AIM The aim of the present meta- analysis was to investigate the long-term effects of glycemic index-related diets in the management of obesity with a special emphasis on the potential benefits of low glycemic index/load ( GI/GL ) in the prevention of obesity-associated risks .
Postprandial Hyperglycemia and Glycemic Variability
The aim of this article is to evaluate the pros and cons of a specific impact of  postpr and ial hyperglycemia and glycemic variability on the — mainly  cardiovascular (CV)—complications of diabetes , above and beyond the average blood glucose ( BG ) as measured by HbA1c or fasting plasma glucose ( FPG ) . The strongest arguments in favor of this hypothesis come from impressive pathophysiological studies , also in the human situation . Measures of oxidative stress and endothelial dysfunction seem to be especially closely related to glucose peaks and even more so to fluctuating high and low glucose concentrations and can be restored to normal by preventing those glucose peaks or wide glucose excursions . The epidemiological evidence , which is more or less confined to postpr and ial hyperglycemia and postglucose load glycemia , is also rather compelling in favor of the hypothesis , although certainly not fully conclusive as there are also a number of conflicting results . The strongest cons are seen in the missing evidence as derived from r and omized prospect i ve intervention studies targeting postpr and ial hyperglycemia longer term , i.e. , over several years , and seeking to reduce hard CV end points . In fact , several such intervention studies in men have recently failed to produce the intended beneficial outcome results . As this evidence by intervention is , however , key for the ultimate approval of a treatment concept in patients with diabetes , the current net balance of attained evidence is not in favor of the hypothesis here under debate , i.e. , that we should care about postpr and ial hyperglycemia and glycemic variability . The absence of a uniformly accepted st and ard of how to estimate these parameters adds a further challenge to this whole debate
No significant changes were observed for blood lipids , anthropometric measures , HbA1c and fasting glucose .
The present systematic review provides evidence for beneficial effects of long-term interventions administering a low glycemic index/load diet with respect to fasting insulin and pro-inflammatory markers such as C-reactive protein which might prove to be helpful in the primary prevention of obesity-associated diseases
AIM The aim of the present meta- analysis was to investigate the long-term effects of glycemic index-related diets in the management of obesity with a special emphasis on the potential benefits of low glycemic index/load ( GI/GL ) in the prevention of obesity-associated risks .