Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension
Purpose The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postpr and ial endothelial dysfunction . Methods This was a single-blind , r and omized , placebo-controlled , crossover-within-subject clinical trial . A total of 37 patients with borderline or stage 1 hypertension were r and omized to two study groups . The participants consumed a test meal with a single intake of the test coffee . Subjects in the Study 1 group were r and omized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover . Subjects in the Study 2 group were r and omized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or placebo coffee with crossover . Endothelial function assessed by flow-mediated vasodilation and plasma concentration of 8-isoprostanes were measured at baseline and at 1 and 2 h after coffee intake . Results Compared with baseline values , single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone , but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee , significantly improved postpr and ial flow-mediated vasodilation and decreased circulating 8-isoprostane levels . Conclusions These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postpr and ial endothelial dysfunction . Clinical Trial Registration URL for Clinical Trial : https://upload.umin.ac.jp ; Registration Number for Clinical Trial : UMIN000013283
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .