In conclusion , it was shown that very high fructose intake ( > 100 g/d ) increases serum LDL-C and TC concentrations .
Fructose is widely used as a sweetener in the production of many foods , yet the relation between fructose intake and cholesterol remains uncertain .
In this study , we performed a systematic review and meta- analysis of human , controlled , feeding trials involving isocaloric fructose exchange for other carbohydrates to quantify the effects of fructose on serum total cholesterol ( TC ) , LDL cholesterol ( LDL-C ) , and  HDL cholesterol ( HDL-C ) in adult humans .
Blood lipids, lipoproteins, apoproteins, and uric acid in men fed diets containing fructose or high-amylose cornstarch.
Ten hyperinsulinemic and 11 nonhyperinsulinemic men consumed for 5 wk each in a cross-over design a diet , similar to one currently consumed in the United States , with 20 % of the kilocalories from either fructose or high-amylose cornstarch to determine the effects of the two diets on various blood metabolites considered to be risk factors associated with heart disease . In the hyperinsulinemic men the intake of fructose as compared with cornstarch significantly increased total triglycerides and their lipoprotein distribution ; total and very-low-density lipoprotein cholesterol ; apoproteins B-100 , C-II , C-III ; and uric acid . In the nonhyperinsulinemic men  total triglycerides , total and low-density lipoprotein cholesterol and uric acid were significantly greater after the consumption of fructose than after cornstarch . The results indicate that in a diet high in saturated fatty acids and cholesterol , fructose increases the levels of risk factors associated with heart disease , especially in hyperinsulinemic men
In conclusion , it was shown that very high fructose intake ( > 100 g/d ) increases serum LDL-C and TC concentrations .
Fructose is widely used as a sweetener in the production of many foods , yet the relation between fructose intake and cholesterol remains uncertain .
In this study , we performed a systematic review and meta- analysis of human , controlled , feeding trials involving isocaloric fructose exchange for other carbohydrates to quantify the effects of fructose on serum total cholesterol ( TC ) , LDL cholesterol ( LDL-C ) , and  HDL cholesterol ( HDL-C ) in adult humans .