Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Sunlight exposure or vitamin D supplementation for vitamin D-deficient non-western immigrants: a randomized clinical trial
Summary Vitamin D deficiency is very common in non-western immigrants . In this r and omized clinical trial , vitamin D 800 IU/day or 100,000 IU/3 months were compared with advised sunlight exposure . Vitamin D supplementation was more effective than advised sunlight exposure in improving vitamin D status and lowering parathyroid hormone levels . Introduction Vitamin D deficiency ( 25-hydroxyvitamin D [ 25(OH)D ] < 25 nmol/l ) is common among non-western immigrants . It can be treated with vitamin D supplementation or sunlight exposure . Methods To determine whether the effect of vitamin D3 supplementation ( daily 800 IU or 100,000 IU/3 months ) or sunlight exposure advice is similar with regard to serum 25(OH)D and parathyroid hormone ( PTH ) concentrations . R and omized clinical trial in 11 general practice s in The Netherl and s. Non-western immigrants , aged 18–65 years ( n = 232 ) and serum 25(OH)D < 25 nmol/l were r and omly assigned to supplementation ( daily 800 IU or 100,000 IU/3 months ) or advice for sunlight exposure for 6 months ( March – September ) . Blood sample s were collected at baseline , during treatment ( 3 months , 6 months ) , and at follow-up ( 12 months ) . Statistical analysis was performed with multilevel regression modelling . Results The intention-to-treat analysis included 211 persons . Baseline serum 25(OH)D was 22.5 ± 11.1 nmol/l . After 6 months , mean serum 25(OH)D increased to 53 nmol/l with 800 IU/day , to 50.5 nmol/l with 100,000 IU/3 months , and to 29.1 nmol/l with advised sunlight exposure ( supplementation vs sunshine p < 0.001 ) . Serum PTH decreased significantly in all groups after 3 months , more in the supplementation groups than in the advised sunlight group ( p < 0.05 ) . There was no significant effect on physical performance and functional limitations . Conclusion Vitamin D supplementation is more effective than advised sunlight exposure for treating vitamin D deficiency in non-western immigrants
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .