Conclusion Overall , our findings do not support the presence of a secondary loss of strength following an acute muscle injury , and strongly suggest that strength , on average , recovers steadily over the first 3 days post-injury
Background An immediate loss of strength follows virtually all types of muscle injury but there is debate whether the initial strength loss is maximal or if a secondary loss of strength occurs during the first 3 days post-injury .
Objective The objective of this analysis was to conduct a systematic review and meta- analysis of the research literature to determine if a secondary loss of strength occurs after an injurious initiating event .
Effects of ibuprofen on exercise-induced muscle soreness and indices of muscle damage.
Thirty-two volunteers participated in a two-period crossover study in which ibuprofen was tested against an identical placebo for its effectiveness in reducing  muscle soreness and damage  after two bouts of downhill running .  Subjective soreness , quadriceps isometric strength and isometric endurance time at 50 percent of maximum strength , serum activities of creatine kinase , lactate dehydrogenase and aspartate transaminase and serum levels of creatinine and urea were recorded at intervals up to 72 hours after exercise . Each downhill run produced muscle soreness , and a decline in muscle strength and 50 percent endurance time , although these parameters were unaffected by ibuprofen treatment . All serum parameters measured increased after both runs , but for the three enzymes this increase was smaller after the second run . Serum creatine kinase and urea levels were higher in the ibuprofen group after both runs . These results indicate that ibuprofen is not an appropriate treatment for delayed onset muscle soreness and damage
Conclusion Overall , our findings do not support the presence of a secondary loss of strength following an acute muscle injury , and strongly suggest that strength , on average , recovers steadily over the first 3 days post-injury
Background An immediate loss of strength follows virtually all types of muscle injury but there is debate whether the initial strength loss is maximal or if a secondary loss of strength occurs during the first 3 days post-injury .
Objective The objective of this analysis was to conduct a systematic review and meta- analysis of the research literature to determine if a secondary loss of strength occurs after an injurious initiating event .