There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .
Intravenous iron sucrose versus oral iron ferrous sulfate for antenatal and postpartum iron deficiency anemia: a randomized trial
Abstract Objective : To compare oral iron to intravenous iron administration to women in late pregnancy and /or after labor to correct iron deficiency . Methods : 271 anemic women ( 148 pregnant women and 123 women post lower segment caesarean section ) with hemoglobin ( Hb ) levels below 110 g/L were enrolled over a two-year period and r and omized to receive either two tablets FGF ( ferrous sulfate with folic acid ) or 400 mg of intravenous iron sucrose plus folic acid 600 µg . Treatment effectiveness was assessed by measuring Hb and ferritin postpartum on day 1 , day 14 and day 42 . Transfusions of red blood cells and adverse drug reactions were recorded . Results : Data of 214 women were available for analysis . Both forms of iron replacement therapy led to increased hemoglobin and ferritin levels over the testing period . Ferritin was significantly higher in the i.v . iron treatment group compared to the oral iron treatment group ( p = 0.004 ) two weeks after delivery , while Hb values did not differ between the groups . No serious adverse drug reactions were observed . Red blood cell transfusion rate was low ( 1.9 % ) , with equal rates observed in both treatment groups . Conclusion : Intravenous and oral irons were both effective in correcting peripartum anemia , although intravenous iron restored stores faster than oral iron
There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .