There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Vitamin E status of low birthweight infants fed formula enriched with long-chain polyunsaturated fatty acids.
It is recommended in Europe that low birthweight infants ( LBWI ) who do not receive human milk ( HM )  should be fed formula enriched with long-chain polyunsaturated fatty acids ( LCP ) . The question has been raised whether LCP supplementation to LBWI formula may have adverse effects on antioxidant status in the recipient infant , particularly on the major lipid-soluble antioxidant vitamin E ( alpha-tocopherol , alpha-toc . ) . We studied alpha-toc . status in LBWI fed HM ( n = 15 ) or formula either without ( f , n = 8) or with LCP derived from egg lipids and fish oil ( LCP-F , n = 9 ) on days 4 and 21 of life . Plasma alpha-toc . concentrations increased significantly in infants fed HM [ d. 4 : 4.53 ( 1.31 ) , d. 21 : 6.35 ( 2.18 ) , mg/l , mean ( SD ) , p < 0.01 ] , whereas there were no changes in infants fed F of LCP-F. Plasma alpha-toc./total lipid ratios and erythrocyte membrane alpha-toc . concentrations did not change significantly between days 4 and 21 in either group . In contrast , erythrocyte membrane alpha-toc./total lipid ratios decreased significantly in infants fed LCP-F [ 0.42 ( 0.13 ) vs. 0.31 ( 0.06 ) , p < 0.05 ] , whereas no change occurred in the other two groups . We conclude that an LCP supplementation based on egg lipids and fish oil to formula may induce an early postnatal decrease of alpha-toc./total lipid ratios in erythrocyte membranes of LBWI . Therefore , the effects of different forms of LCP supplementation to infant formula on infantile vitamin E status should be carefully evaluated
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .