There were no significant differences regarding the biomechanical axis or frontal femoral and individual tibial component alignment .
Conclusion This systematic review and meta- analysis demonstrate that alignment with MRI-based PSI is at least as good as , if not better than , that with CT-based PSI .
Purpose Patient-specific instruments ( PSIs ) are already in relatively common use , and their post-operative radiographic results are equal to those for total knee arthroplasty ( TKA ) with conventional instrumentation .
PSI use requires a preoperative MRI scan , CT scan , or a combination of MRI and a long-leg st and ing radiograph .
However , there is no consensus as to which of these modalities , MRI or CT , is the preferred imaging modality when performing TKA with PSIs .
The accuracy of component alignment in custom cutting blocks compared with conventional total knee arthroplasty instrumentation: prospective control trial.
BACKGROUND The purpose of this study was to assess whether custom cutting blocks improve accuracy of component alignment compared to conventional TKA instrumentation . METHODS Eighty primary TKA patients were enrolled in an open-label r and omized prospect i ve clinical trial and were divided into two groups , 40 custom cutting blocks and 40 conventional TKA instrumentations . The primary outcome was prosthetic alignment with respect to mechanical axis and epicondylar axis . Secondary outcomes included operative time , 24-hour postoperative blood loss and hemoglobin at discharged . RESULTS There were no statistical significant differences in the postoperative mechanical axis between the custom cutting blocks group and conventional TKA group , ( 95 % vs. 87.5 % within 3 ° of neutral mechanical alignment , p=0.192 ) . The average rotational alignment was statistically significantly different in the custom cutting blocks group ( 1.0 ° ±0.6 ° vs. 1.6 ° ±1.8 ° external rotation from epicondylar axis , p<0.001 ) . There were statistical significant differences in operation time  between custom cutting blocks group and conventional group , skin to skin [ 57.5±2.3 min vs. 62.1±1.5 , p<0.001 ] . We found an improvement in group 1 compared with group 2 regarding the proportion of patients with postoperative blood loss within 24 h. CONCLUSIONS Custom cutting blocks technique was a surgical procedure which provided better accuracy in rotational alignment but no statistical differences in mechanical axis , less operative time and reduced blood loss  than the conventional TKA instrumentation in the majority of patients
There were no significant differences regarding the biomechanical axis or frontal femoral and individual tibial component alignment .
Conclusion This systematic review and meta- analysis demonstrate that alignment with MRI-based PSI is at least as good as , if not better than , that with CT-based PSI .
Purpose Patient-specific instruments ( PSIs ) are already in relatively common use , and their post-operative radiographic results are equal to those for total knee arthroplasty ( TKA ) with conventional instrumentation .
PSI use requires a preoperative MRI scan , CT scan , or a combination of MRI and a long-leg st and ing radiograph .
However , there is no consensus as to which of these modalities , MRI or CT , is the preferred imaging modality when performing TKA with PSIs .