Conclusions and implication s of key findings : Fluoxetine is associated with a significantly greater reduction in OCD severity , as measured by the CY-BOCS , NIMH-OC and CGI-S , in children and adolescents .
Additionally , it is well tolerated in children and adolescents .
The acceptability is comparable to that of the placebo-treated group .
Background : Obsessive-compulsive disorder ( OCD ) is a common psychiatric illness in children and adolescents .
Previous evidence suggests that fluoxetine is effective in the treatment of OCD in children and adolescents .
However , those studies had small sample sizes .
As a result , a systematic review , which is a more powerful method to calculate the true effect size , can be applied to examine the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Objectives : The aims of this study were to review the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Fluoxetine in children and adolescents with OCD: a placebo-controlled trial.
OBJECTIVE To examine the safety and efficacy of fluoxetine in child and adolescent obsessive-compulsive disorder ( OCD ) . METHOD Between 1991 and 1998 , 43 patients were r and omly assigned to fluoxetine or placebo for 8 weeks . Dosing was fixed for the first 6 weeks ( up to 60 mg/day ) and then could be increased to 80 mg/day . Responders entered an 8-week maintenance phase . The primary outcome measures were the Children 's Yale-Brown Obsessive Compulsive Scale ( CY-BOCS ) and the Clinical Global Impression-Improvement ( CGI-I ) scale . Analyses were done on the intent-to-treat sample . RESULTS Fluoxetine patients ( n = 21 ) had significantly lower CY-BOCS scores than placebo patients ( n = 22 ) after 16 ( but not 8) weeks . Fluoxetine responders ( n = 11 ) had significantly lower CY-BOCS scores than placebo responders ( n = 7 ) after an additional 8 weeks of treatment . After 16 weeks , 57 % of fluoxetine ( versus 27 % of placebo ) patients were much or very much improved on the CGI-I scale ( p < .05 ) . No patient terminated the study because of adverse medication effects . CONCLUSION Fluoxetine was well tolerated and effective for the treatment of child and adolescent OCD , but fluoxetine 's full effect took more than 8 weeks to develop
Conclusions and implication s of key findings : Fluoxetine is associated with a significantly greater reduction in OCD severity , as measured by the CY-BOCS , NIMH-OC and CGI-S , in children and adolescents .
Additionally , it is well tolerated in children and adolescents .
The acceptability is comparable to that of the placebo-treated group .
Background : Obsessive-compulsive disorder ( OCD ) is a common psychiatric illness in children and adolescents .
Previous evidence suggests that fluoxetine is effective in the treatment of OCD in children and adolescents .
However , those studies had small sample sizes .
As a result , a systematic review , which is a more powerful method to calculate the true effect size , can be applied to examine the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Objectives : The aims of this study were to review the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .