LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Efficacy and Safety of Fluvastatin-Extended Release in Hypercholesterolemic Patients: Morning Administration Is Equivalent to Evening Administration
Background : Flexibility in the time of administration of statin therapy is likely to improve patient compliance . This study compared the efficacy and tolerability of morning and evening administration of the extended-release formulation of fluvastatin ( fluvastatin XL ) . Methods : In this prospect i ve , double-blind , multicenter , multiple dose study , 236 patients with type IIa/b hypercho lesterolemia were r and omized to receive fluvastatin XL , 80 mg , in the morning or evening for 8 weeks . Results : At 8 weeks , low-density lipoprotein cholesterol levels were reduced by 34.5 and 35.0 % in the morning and evening treatment groups , respectively ( p = 0.0118 for non-inferiority of morning administration ) . There were no statistically significant differences between the morning and evening treatment groups in the changes in total cholesterol ( p = 0.56 ) , high-density lipoprotein cholesterol ( p = 0.21 ) , triglycerides ( p = 0.13 ) , apolipoprotein B ( p = 0.66 ) and apolipoprotein AI ( p = 0.88 ) at 8 weeks . The frequency of adverse events was slightly lower in the morning treatment group compared with the evening treatment group ( 27.4 vs. 35.5 % ) . Conclusions : The efficacy and safety profiles of fluvastatin XL are equivalent for morning and evening administration
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .