Results : We confirmed the importance of the 4 main factors influencing SC : ( 1 ) environmental factors , ( 2 ) genomic factors , ( 3 ) gene-environment interactions , and ( 4 ) evidence -based interventions .
The model demonstrates the complex network of factors influencing SC .
Background : Smoking behaviour is a major public health problem worldwide .
Several sources have confirmed the implication of genomic factors in smoking behaviour .
These factors interact both with environmental factors and interventions to develop a certain behaviour .
Objectives : Describing the environmental and genomic factors as well as the interventions influencing smoking cessation  ( SC ) and developing a working model incorporating the different factors influencing SC were our main objectives .
Association of COMT Val108/158Met Genotype with Smoking Cessation in a Nicotine Replacement Therapy Randomized Trial
We investigated the association of catechol O-methyltransferase ( COMT ) genotype with abstinence following a smoking cessation attempt among a large cohort of smokers who attempted to quit using either the nicotine transdermal patch or placebo and were followed up over an 8-year period following their initial cessation attempt . In addition , we examined the possible moderating influence of sex on any association . The genotype × treatment interaction effect at 12-week follow-up indicated a greater benefit of active nicotine replacement treatment compared with placebo on likelihood of abstinence in the COMT Met/Met genotype group ( 33 % versus 12 % ) , in comparison to the Met/Val + Val/Val group ( 22 % versus 16 % ) . Our results indicate that COMT genotype may moderate the effect of active transdermal nicotine patch  compared with placebo , with reduced relative benefit of nicotine replacement therapy in individuals with Met/Val or Val/Val genotype . Our data follow an emerging pattern of results suggesting that genetic variation in the dopamine pathway may provide a future basis for tailored smoking cessation therapies , but indicate that different genes influencing various components of this pathway may have different effects on response to smoking cessation pharmacotherapy . ( Cancer Epidemiol Biomarkers Prev 2007;16(6):1065–9
Results : We confirmed the importance of the 4 main factors influencing SC : ( 1 ) environmental factors , ( 2 ) genomic factors , ( 3 ) gene-environment interactions , and ( 4 ) evidence -based interventions .
The model demonstrates the complex network of factors influencing SC .
Background : Smoking behaviour is a major public health problem worldwide .
Several sources have confirmed the implication of genomic factors in smoking behaviour .
These factors interact both with environmental factors and interventions to develop a certain behaviour .
Objectives : Describing the environmental and genomic factors as well as the interventions influencing smoking cessation  ( SC ) and developing a working model incorporating the different factors influencing SC were our main objectives .