Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Green coffee bean extract improves human vasoreactivity.
Our previous study revealed the antihypertensive effects of green coffee bean extract ( GCE ) ingestion in spontaneously hypertensive rats . We suggested that this antihypertensive action was due to the fact that GCE contains chlorogenic acid ( CQA ) as a major phenolic compound , and CQA in turn contains ferulic acid as a metabolic component that acts on nitric oxide ( NO ) derived from the vascular endothelium . In this study , the effects of GCE on blood vessels were evaluated in healthy males . The subjects were 20 healthy males with reduced vasodilation responses measured by strain gauge plethysmograms ( SPG ) to ischemic reactive hyperemia . Of the 20 subjects , 10 ( mean age , 37.2 years ) ingested a test drink containing GCE ( CQA : 140 mg/day ) , and the other 10 ( mean age , 34.8 years ) ingested a placebo drink for 4 months . During the ingestion period , SPG , pulse wave velocity ( PWV ) , and serum biochemical parameters were measured , and acceleration plethysmograms ( APG ) were taken . The reactive hyperemia ratio ( RHR ) in the test drink group began to increase after ingestion for 1 month and was significantly higher ( p < 0.05 ) than that in the placebo group after ingestion for 3 months and 4 months . In addition , after ingestion for 4 months , the test drink group showed a significant decrease ( p < 0.01 ) in the plasma total homocysteine level compared with the pre-ingestion level . However , there were no significant differences in PWV or APG between the test drink group and the placebo drink group . The improvement in RHR after ingestion of a drink containing GCE suggested an improvement in vasoreactivity by this component
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .