Our meta‐ analysis showed beneficial effects  of statin use  on reducing inflammatory markers in patients with MetS and related disorders
& NA ; Current evidence suggests that statin use decreases the incidence of cardiovascular diseases ( CVD ) through reducing LDL cholesterol and decreasing inflammation .
Metabolic syndrome ( MetS ) is usually associated with increased inflammatory markers and increased risk of CVD .
Concomitant reduction of low-density lipoprotein-cholesterol and biomarkers of inflammation with low-dose simvastatin therapy in patients with type 1 diabetes.
CONTEXT Cardiovascular disease is a major cause of mortality in type 1 diabetes ( TIDM ) . TIDM is a proinflammatory state . Whereas there is consensus on lipid management in type 2 diabetes , there is a lack of data in type 1 diabetes . In addition to benefits on the lipid profile , statin therapy is antiinflammatory . OBJECTIVE There are scant data on statin therapy in T1DM . Thus , we tested the effect of simvastatin , compared with placebo , on biomarkers of inflammation and monocyte function in TIDM patients . DESIGN This was a double-blind , r and omized , placebo-controlled study of T1DM patients , r and omized to placebo or simvastatin , 20 mg/d for 3 months . SETTING The study was conducted at the University of California , Davis , Medical Center . PARTICIPANTS Participants included patients with T1DM . METHODS AND RESULTS Analytes measured at baseline and 3 months included liver function tests , creatinine , hemoglobin AIC , high-sensitivity C-reactive protein , soluble CD40 lig and , monocyte O(2)(- ) , cytokines , nuclear factor-kappaB.  Simvastatin therapy result ed in significant reduction in low-density lipoprotein and non-high-density lipoprotein cholesterol , high-sensitivity C-reactive protein ( 18 % reduction , P < 0.001 ) and soluble CD40 lig and ( 22 % reduction , P < 0.05 ) , compared with placebo . Simvastatin therapy significantly inhibited lipopolysaccharide-activated monocyte release of O(2)(- ) ( P < 0.0005 ) , IL-8 ( P < 0.03 ) , and TNF ( P < 0.02 ) . Simvastatin therapy significantly inhibited monocyte IL-6 release , compared with baseline ( P = 0.02 ) . Simvastatin therapy also significantly reduced monocytic nuclear factor-kappaB p65 activity , compared with placebo ( P < 0.01 ) . CONCLUSIONS This study demonstrates that simvastatin ( 20 mg/d ) is safe in T1DM patients and has concomitant benefits on the lipid profile and biomarkers of inflammation . These novel findings could have implication s for developing policy guidelines for statin therapy in forestalling vascular complications in young T1DM
Our meta‐ analysis showed beneficial effects  of statin use  on reducing inflammatory markers in patients with MetS and related disorders
& NA ; Current evidence suggests that statin use decreases the incidence of cardiovascular diseases ( CVD ) through reducing LDL cholesterol and decreasing inflammation .
Metabolic syndrome ( MetS ) is usually associated with increased inflammatory markers and increased risk of CVD .