The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
The Effect of Ramipril on Ambulatory Blood Pressure: A Multicenter Trial
The antihypertensive efficacy of ramipril was evaluated using 24-h noninvasive ambulatory sphygmomanometry in this double-blind , placebo-controlled study . One hundred subjects with mild-to-moderate essential hypertension were r and omized to ramipril , 10 mg or placebo once daily for a 4-week treatment period . Ramipril decreased systolic and diastolic blood pressures throughout the 24-h period after dosing . Blood pressures measured manually 24 h postdose also showed that ramipril significantly reduced supine and st and ing blood pressures when compared with placebo . Incidences of adverse events were similar in the two study groups . Ramipril proved to be a well-tolerated agent with a sustained 24-h antihypertensive effect in this study
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .