Pooled analyses demonstrated conditional triglyceride-raising and total cholesterol – lowering  effects of isocaloric fructose exchange for carbohydrate in type 2 diabetes .
OBJECTIVE Because of blood lipid concerns , diabetes associations discourage fructose at high intakes .
To quantify the effect of fructose  on blood lipids in diabetes , we conducted a systematic review and meta- analysis of experimental clinical trials investigating the effect of isocaloric fructose exchange for carbohydrate on triglycerides , total cholesterol , LDL cholesterol , and HDL cholesterol in type 1 and 2 diabetes .
Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes.
OBJECTIVE In normal adults , a small ( catalytic ) dose of fructose administered with glucose decreases the glycemic response to a glucose load , especially in those with the poorest glucose tolerance . We hypothesized that an acute catalytic dose of fructose would also improve glucose tolerance in individuals with type 2 diabetes . RESEARCH DESIGN AND METHODS Five adults with type 2 diabetes underwent an oral glucose tolerance test ( OGTT ) on two separate occasions , at least 1 week apart . Each OGTT consisted of 75 g glucose with or without the addition of 7.5 g fructose ( OGTT + F or OGTT - F ) , in r and om order . Arterialized blood sample s were collected from a heated dorsal h and vein twice before ingestion of the carbohydrate and every 15 min for 3 h afterward . RESULTS The area under the curve ( AUC ) of the plasma glucose response was reduced by fructose administration in all subjects ; the mean AUC during the OGTT + F was 14 % less than that during the OGTT - F ( P < 0.05 ) . The insulin AUC was decreased 21 % with fructose administration ( P = 0.2 ) . Plasma glucagon concentrations declined similarly during OGTT - F and OGTT + F. The incremental AUC of the blood lactate response during the OGTT - F was approximately 50 % of that observed during the OGTT + F ( P < 0.05 ) . Neither nonesterified fatty acid nor triglyceride concentrations differed between the two OGTTs . CONCLUSIONS Low-dose fructose improves the glycemic response to an oral glucose load in adults with type 2 diabetes , and this effect is not a result of stimulation of insulin secretion
Pooled analyses demonstrated conditional triglyceride-raising and total cholesterol – lowering  effects of isocaloric fructose exchange for carbohydrate in type 2 diabetes .
OBJECTIVE Because of blood lipid concerns , diabetes associations discourage fructose at high intakes .
To quantify the effect of fructose  on blood lipids in diabetes , we conducted a systematic review and meta- analysis of experimental clinical trials investigating the effect of isocaloric fructose exchange for carbohydrate on triglycerides , total cholesterol , LDL cholesterol , and HDL cholesterol in type 1 and 2 diabetes .