Overall , the current meta- analysis demonstrated that resveratrol intake significantly reduced weight , BMI , WC and fat mass , and significantly increased lean mass , but did not affect leptin and adiponectin levels
Abstract This systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to summarize the effect of resveratrol intake on weight loss .
An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol.
BACKGROUND Resveratrol have been shown to exert an antiinflammatory and antiaging effects in vitro and in animal models . OBJECTIVE The objective of the study was to investigate the effect of a Polygonum cuspidatum extract ( PCE ) containing resveratrol on oxidative and inflammatory stress in normal subjects . RESEARCH DESIGN AND METHODS Two groups ( 10 each ) of normal-weight healthy subjects were r and omized to placebo or PCE containing 40 mg resveratrol daily for 6 wk . Fasting blood sample s were obtained prior to and after treatment at 1 , 3 , and 6 wk . Mononuclear cells were prepared for reactive oxygen species generation , RNA isolation , nuclear extract , and total cell homogenate preparation . Indices of oxidative and inflammatory stress , suppressor of cytokine signaling-3 , phosphotyrosine phosphatase-1B , jun-N-terminal kinase-1 , and inhibitor of kappaB-kinase-beta were measured by RT-PCR and Western blotting . RESULTS The extract induced a significant reduction in reactive oxygen species generation , the expression of p47(phox ) , intranuclear nuclear factor-kappaB binding , and the expression of jun-N-terminal kinase-1 , inhibitor of kappaB-kinase-beta , phosphotyrosine phosphatase-1B , and suppressor of cytokine signaling-3 in mononuclear cells when compared with the baseline and the placebo . PCE intake also suppressed plasma concentrations of TNF-alpha , IL-6 , and C-reactive protein . There was no change in these indices in the control group given placebo . CONCLUSIONS The PCE-containing resveratrol has a comprehensive suppressive effect on oxidative and inflammatory stress
Overall , the current meta- analysis demonstrated that resveratrol intake significantly reduced weight , BMI , WC and fat mass , and significantly increased lean mass , but did not affect leptin and adiponectin levels
Abstract This systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to summarize the effect of resveratrol intake on weight loss .