This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
The effects of vitamin D supplementation on adiponectin level and insulin resistance in first-degree relatives of subjects with type 2 diabetes: a randomized double-blinded controlled trial
Background Despite the certain role of both vitamin D and adiponectin in the regulation of insulin sensitivity , the interaction between these two agents has remained uncertain . Objective The present study aim ed to determine whether vitamin D is able to change plasma adiponectin and affect glucose homeostasis and insulin sensitivity in first-degree relatives of subjects with type 2 diabetes . Methods This r and omized clinical trial was conducted at Clinic of Shahid Sadoughi Hospital in Yazd , Iran , from January 25 , 2012 to December 25 , 2014 . In this r and omized , double-blinded controlled trial , 64 first-degree relatives of type 2 diabetic patients were assigned r and omly to receive either vitamin D supplement ( 50000 IU vitamin D tablet weekly ) plus lifestyle change as the intervention group ( n = 32 ) or placebo plus lifestyle change as the control group ( n = 32 ) for twelve weeks ( three months ) . Results Fifty-three patients ( 28 in the intervention group and 25 in the control group ) completed the study . Serum levels of vitamin D  increased while insulin level and consequently insulin resistance ( calculated by HOMA formula ) significantly decreased in the case group ( p-value < 0.001 for all variables ) . Although the values of these three biomarkers showed a slight increase in control group , the changes were not statistically significant . The levels of the changes in other markers including adiponectin , Fasting Blood Sugar ( FBS ) , triglyceride , and total cholesterol remained insignificant in both study groups after completing interventions compared with before interventions . Conclusion This study showed that decreased insulin resistance is expected by administrating vitamin D supplement in first-degree relatives of the patients with diabetes mellitus . Trial Registration The trial was registered at the Iranian Registry of Clinical Trials ( http://www.i rct .ir ) with the I RCT ID : 201105176430N1 . Funding The authors received no financial support for the research or publication of this article
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .