However , mechanistic studies found significant improvements in hippocampal neuronal health and brain glutathione .
CONCLUSION There is preliminary evidence that taurine improves outcomes in FEP , whereas effects of omega-3 and antioxidant vitamins/amino-acids are inconsistent ; perhaps mainly benefitting patients with high levels of oxidative stress .
AIM The effects of nutrient-based treatments , including adjunctive vitamin or antioxidant supplementation , have been explored extensively in long-term schizophrenia .
However , no systematic evaluation of trials in " first-episode psychosis " ( FEP ) has been conducted , despite the potential benefits of using these treatments during the early stages of illness .
Therefore , we aim ed to review all studies examining efficacy , tolerability and the biological mechanisms of action , of nutrient supplementation in FEP .
A randomised trial of nutrient supplements to minimise psychological stress after a natural disaster
After devastating flooding in southern Alberta in June 2013 , we attempted to replicate a New Zeal and r and omised trial that showed that micronutrient ( minerals , vitamins ) consumption after the earthquakes of 2010 - 11 result ed in improved mental health .  Residents of southern Alberta were invited to participate in a study on the potential benefit of nutrient supplements following a natural disaster . Fifty-six adults aged 23 - 66 were r and omised to receive a single nutrient ( vitamin D , n=17 ) , a few-nutrients formula ( B-Complex , n=21 ) , or a broad-spectrum mineral/vitamin formula ( BSMV , n=18 ) . Self-reported changes in depression , anxiety and stress were monitored for six weeks . Although all groups showed substantial decreases on all measures , those consuming the B-Complex and the BSMV formulas showed significantly greater improvement in stress and anxiety compared with those consuming the single nutrient , with large effect sizes ( Cohen 's d range 0.76 - 1.08 ) . There were no group differences between those consuming the B-Complex and BSMV . The use of nutrient formulas with multiple minerals and /or vitamins to minimise stress associated with natural disasters is now supported by three studies . Further research should be carried out to evaluate the potential population benefit that might accrue if such formulas were distributed as a post-disaster public health measure
However , mechanistic studies found significant improvements in hippocampal neuronal health and brain glutathione .
CONCLUSION There is preliminary evidence that taurine improves outcomes in FEP , whereas effects of omega-3 and antioxidant vitamins/amino-acids are inconsistent ; perhaps mainly benefitting patients with high levels of oxidative stress .
AIM The effects of nutrient-based treatments , including adjunctive vitamin or antioxidant supplementation , have been explored extensively in long-term schizophrenia .
However , no systematic evaluation of trials in " first-episode psychosis " ( FEP ) has been conducted , despite the potential benefits of using these treatments during the early stages of illness .
Therefore , we aim ed to review all studies examining efficacy , tolerability and the biological mechanisms of action , of nutrient supplementation in FEP .