Results The majority of studies demonstrated RE as an effective and safe intervention to improve muscular strength and performance , fatigue and quality of life ( QoL ) in PCaPs , while there is inconclusive evidence concerning cardiovascular performance , body composition , blood lipids , bone mineral density ( BMD ) , and immune response .
Purpose Physical exercise has been shown to be an effective , safe , and quite inexpensive method to reduce cardiovascular and metabolic risk factors and is currently in the process of establishing its relevance for cancer specific morbidity and mortality .
The aim of this systematic review was to focus on specific effects of resistance exercise ( RE ) in the adjuvant therapy and rehabilitation of prostate cancer patients ( PCaPs ) receiving or having received and rogen deprivation therapy ( ADT ) .
Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy.
Insulin resistance and changes in body composition are side effects of and rogen deprivation therapy ( ADT ) given to prostate cancer patients . The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients . Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12  weeks  of endurance training . Primary endpoints were insulin sensitivity ( euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion ) and body composition ( dual-energy X-ray absorptiometry and magnetic resonance imaging ) . The secondary endpoint was systemic inflammation . Statistical analysis was carried out using two-way ANOVA . Endurance training increased VO2max ( ml(O2)/min per kg ) by 11 and 13 % in the patients and controls respectively ( P<0.0001 ) . The patients and controls demonstrated an increase in peripheral tissue insulin sensitivity of 14 and 11 % respectively ( P<0.05 ) , with no effect on hepatic insulin sensitivity ( P=0.32 ) . Muscle protein content of GLUT4 ( SLC2A4 ) and total AKT ( AKT1 ) was also increased in response to the training ( P<0.05 and P<0.01 respectively ) . Body weight ( P<0.0001 ) and whole-body fat mass ( FM ) ( P<0.01 ) were reduced , while lean body mass ( P=0.99 ) was unchanged . Additionally , reductions were observed in abdominal ( P<0.01 ) , subcutaneous ( P<0.05 ) , and visceral ( P<0.01 ) FM amounts . The concentrations of plasma markers of systemic inflammation were unchanged in response to the training . No group × time interactions were observed , except for thigh intermuscular adipose tissue ( IMAT ) ( P=0.01 ) , reflecting a significant reduction in the amount of IMAT in the controls ( P<0.05 ) not observed in the patients ( P=0.64 ) . In response to endurance training , ADT-treated prostate cancer patients exhibited improved insulin sensitivity and body composition to a similar degree as eugonadal men
Results The majority of studies demonstrated RE as an effective and safe intervention to improve muscular strength and performance , fatigue and quality of life ( QoL ) in PCaPs , while there is inconclusive evidence concerning cardiovascular performance , body composition , blood lipids , bone mineral density ( BMD ) , and immune response .
Purpose Physical exercise has been shown to be an effective , safe , and quite inexpensive method to reduce cardiovascular and metabolic risk factors and is currently in the process of establishing its relevance for cancer specific morbidity and mortality .
The aim of this systematic review was to focus on specific effects of resistance exercise ( RE ) in the adjuvant therapy and rehabilitation of prostate cancer patients ( PCaPs ) receiving or having received and rogen deprivation therapy ( ADT ) .