A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?
Multimodal exercise training during myeloablative chemotherapy: a prospective randomized pilot trial
Purpose Cancer and its treatment-related side effects induce loss of physical performance . This study evaluated the effects of multimodal aerobic and strength exercises on physical performance in hospitalized cancer patients while receiving myeloablative chemotherapy . Methods In this prospect i ve pilot study , 48 evaluable patients were r and omly assigned to a training ( TG , n = 24 ) or control ( CG , n = 24 ) group . The TG performed an individually supervised exercise program five times a week with ergometer training and strength exercises for 20 min each during the hospitalization period for chemotherapy . The CG received st and ard physiotherapy .  Physical performance was evaluated using spiroergometry , lung function , and muscle strength testing . Treatment-related side effects were assessed by daily interviews , quality of life by EORTC-QLQ-C30 , and fatigue using the Modified Fatigue Impact Scale ( MFIS ) question naire . Results Physical performance significantly increased in the TG ( 8.96 ± 24 W ) and decreased in the CG ( −7.24 ± 20 W , p = 0.02 ) . At 2-mmol/ml blood lactate concentration , the TG achieved significantly increased oxygen consumption ( p = 0.03 ) and expiratory minute ventilation ( p = 0.04 ) compared to the CG . Furthermore , physical functioning increased significantly in the TG ( p = 0.04 ) . Patients in the TG required less antiemetics ( p = 0.01 ) and experienced significantly less fatigue ( p = 0.04 ) , although MFIS analysis was not able to detect this beneficial effect . Patients of the CG displayed higher impairments of cognitive ( p = 0.02 ) and psychosocial function ( p = 0.03 ) after chemotherapy . No adverse events due to the study intervention were observed . Conclusions Multimodal exercise has beneficial effects on physical performance , physical functioning , and treatment-related symptoms even during myeloablative chemotherapy . We suggest an enhanced physical activity intervention program during hospitalization of cancer patients
A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?