This meta- analysis suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-α
We conducted this systematic review and meta- analysis of prospect i ve studies to determine the effect of  probiotic administration on serum C-reactive protein ( CRP ) concentrations .
Perioperative Synbiotic Treatment to Prevent Postoperative Infectious Complications in Biliary Cancer Surgery: A Randomized Controlled Trial
Summary Background Data : Use of synbiotics has been reported to benefit human health , but clinical value in surgical patients remains unclear . Objective : To investigate the effect of perioperative oral administration of synbiotics upon intestinal barrier function , immune responses , systemic inflammatory responses , microflora , and surgical outcome in patients undergoing high-risk hepatobiliary resection . Methods : Patients with biliary cancer involving the hepatic hilus ( n = 101 ) were r and omized before hepatectomy  , into a group receiving postoperative enteral feeding with synbiotics ( group A ) ; or another receiving preoperative plus postoperative synbiotics ( group B ) . Lactulose-mannitol ( L/M ) ratio , serum diamine oxidase ( DAO ) activity , natural killer ( NK ) cell activity , interleukin-6 ( IL-6 ) , fecal microflora , and fecal organic acid concentrations were determined before and after hepatectomy . Postoperative infectious complications were recorded . Results : Of 101 patients , 81 completed the trial . Preoperative and postoperative changes in L/M ratio and DAO activity were similar between groups . Preoperatively in group B , NK activity , and lymphocyte counts increased , while IL-6 decreased significantly ( P < 0.05 ) . Postoperative serum IL-6 , white blood cell counts , and C-reactive protein in group B were significantly lower than in group A ( P < 0.05 ) . During the preoperative period , numbers of Bifidobacterium colonies cultured from and total organic acid concentrations measured in feces increased significantly in group B ( P < 0.05 ) . Postoperative concentrations of total organic acids and acetic acid in feces were significantly higher in group B than in group A ( P < 0.05 ) . Incidence of postoperative infectious complications was 30.0 % ( 12 of 40 ) in group A and 12.1 % ( 5 of 41 ) in group B ( P < 0.05 ) . Conclusions : Preoperative oral administration of synbiotics can enhance immune responses , attenuate systemic postoperative inflammatory responses , and improve intestinal microbial environment . These beneficial effects likely reduce postoperative infectious complications after hepatobiliary resection for biliary tract cancer
This meta- analysis suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-α
We conducted this systematic review and meta- analysis of prospect i ve studies to determine the effect of  probiotic administration on serum C-reactive protein ( CRP ) concentrations .