Conclusions and implication s of key findings : Fluoxetine is associated with a significantly greater reduction in OCD severity , as measured by the CY-BOCS , NIMH-OC and CGI-S , in children and adolescents .
Additionally , it is well tolerated in children and adolescents .
The acceptability is comparable to that of the placebo-treated group .
Background : Obsessive-compulsive disorder ( OCD ) is a common psychiatric illness in children and adolescents .
Previous evidence suggests that fluoxetine is effective in the treatment of OCD in children and adolescents .
However , those studies had small sample sizes .
As a result , a systematic review , which is a more powerful method to calculate the true effect size , can be applied to examine the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Objectives : The aims of this study were to review the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
A randomized controlled clinical trial of Citalopram versus Fluoxetine in children and adolescents with obsessive-compulsive disorder (OCD)
ObjectiveS everal controlled trials have demonstrated the efficacy and safety of Fluoxetine in children and adolescents with Obsessive-Compulsive Disorder ( OCD ) , but there is no controlled study on the effectiveness of Citalopram in this group . This report describes the use of Citalopram in comparison with Fluoxetine in childhood-onset OCD . Method This study is a r and omized , double blind , fixed-does ( 20 mg ) trial of Fluoxetine versus Citalopram in 29 children and adolescents ( 17 boys and 12 girls ) with OCD , aged 7–18 years ( mean 13.8 and SD 3.05 ) . The length of study was 6 weeks . Obsessive-Compulsive symptom severity was measured by Yale – Brown Obsessive-Compulsive Scale ( CY-BOCS ) and Clinician ’s Global Impression Scale ( CGI ) . DICA ( Diagnostic Interview of Children and Adolescents ) was used to diagnose the psychiatric disorders . Results Each group showed significant improvement over the baseline as measured by the CY-BOCS ( p < 0.01 ) but not by CGI ( p = NS ) . The Comparison between two groups showed no significant differences in efficacy and safety of the drugs . Most common adverse effects were headache for Citalopram and tremor for Fluoxetine . Conclusion The results suggest that Citalopram is as safe and effective as Fluoxetine for children and adolescents with OCD . Further studies are needed to replicate our findings
Conclusions and implication s of key findings : Fluoxetine is associated with a significantly greater reduction in OCD severity , as measured by the CY-BOCS , NIMH-OC and CGI-S , in children and adolescents .
Additionally , it is well tolerated in children and adolescents .
The acceptability is comparable to that of the placebo-treated group .
Background : Obsessive-compulsive disorder ( OCD ) is a common psychiatric illness in children and adolescents .
Previous evidence suggests that fluoxetine is effective in the treatment of OCD in children and adolescents .
However , those studies had small sample sizes .
As a result , a systematic review , which is a more powerful method to calculate the true effect size , can be applied to examine the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Objectives : The aims of this study were to review the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .