The National Eye Institute Visual Function Question naire-25 , Impact of Vision Impairment and Treatment Satisfaction Survey-Intraocular Pressure had the highest number of positive ratings in the content validity assessment .
Conclusion This study provides a descriptive catalogue of vision-specific PRO instruments , to inform the choice of an appropriate measure of patient-reported outcomes in a glaucoma context
Purpose To identify  vision Patient-Reported Outcomes instruments relevant to glaucoma and assess their content validity .
Early Manifest Glaucoma Trial: design and baseline data.
OBJECTIVES The Early Manifest Glaucoma Trial ( EMGT ) will evaluate the effectiveness of reducing intraocular pressure ( IOP ) in early , previously untreated open-angle glaucoma . Its secondary aims are to explore factors related to glaucoma progression and to study the natural history of the disease . This article describes the EMGT design and presents baseline data . DESIGN R and omized , clinical trial . PARTICIPANTS Newly diagnosed patients 50 to 80 years of age with early glaucomatous visual field defects were mainly identified from a population -based screening of more than 44,000 residents of Malmö and Helsingborg , Sweden . Exclusion criteria were advanced visual field loss ; mean IOP greater than 30 mmHg or any IOP greater than 35 mmHg ; visual acuity less than 0.5 ; and inability to complete follow-up protocol s. INTERVENTIONS After informed consent , patients were r and omized to treatment or no initial treatment with close follow-up . Treated patients had laser trabeculoplasty and started receiving topical betaxolol twice daily in eligible eyes . Follow-up visits include computerized perimetry and tonometry every 3 months and fundus photography every 6 months . Decisions to change or begin treatment are made jointly with the patient when EMGT progression occurs and also later if clinical ly needed . MAIN OUTCOME MEASURES The EMGT progression is defined by sustained increases of visual field loss in three consecutive C30 - 2 Humphrey tests , as determined from computer-based analyses , or by optic disc changes , as determined from flicker chronoscopy and side-by-side comparisons of fundus photographs performed by masked , independent grade rs . RESULTS A total of 255 patients were r and omized between 1993 and 1997 and will be followed for at least 4 years . All had generally good health status ; mean age was 68.1 years , and 66 % were women . At baseline , mean IOP was 20.6 mmHg and 80 % of eyes had IOP less than 25 mmHg . CONCLUSIONS The Early Manifest Glaucoma Trial is the first large r and omized , clinical trial to evaluate the role of immediate pressure reduction , as compared to no initial reduction , in patients with early glaucoma and normal or moderately elevated IOP . Its results will have implication s for : ( 1 ) the clinical management of glaucoma ; ( 2 ) underst and ing the role of IOP and the natural history of glaucoma ; and ( 3 ) evaluating the rationale for glaucoma screening
The National Eye Institute Visual Function Question naire-25 , Impact of Vision Impairment and Treatment Satisfaction Survey-Intraocular Pressure had the highest number of positive ratings in the content validity assessment .
Conclusion This study provides a descriptive catalogue of vision-specific PRO instruments , to inform the choice of an appropriate measure of patient-reported outcomes in a glaucoma context
Purpose To identify  vision Patient-Reported Outcomes instruments relevant to glaucoma and assess their content validity .