There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo.
BACKGROUND Several studies found a benefit of long-chain polyunsaturated fatty acid ( LCP ) supplementation for visual or mental development , but others found no benefit . Likely contributors to differences among studies are the amount of LCP supplementation , functional outcomes , and sample size . OBJECTIVE We evaluated LCP supplementation in amounts typical for human milk ( based on local and worldwide surveys ) in a large cohort of infants by using sweep visual evoked potential ( VEP ) acuity as the functional outcome . DESIGN The study was a double-masked , r and omized , controlled clinical trial in 103 term infants . By age 5 d , infants were r and omly assigned to receive either formula with no docosahexaenoic acid ( DHA ) or arachidonic acid ( ARA ) or formula supplemented with DHA and ARA as 0.36 % and 0.72 % , respectively , of total fatty acids .  Sweep VEP acuity was the primary outcome . R and om dot stereoacuity , blood lipid profile , growth , and tolerance were secondary outcomes . RESULTS VEP acuity in the LCP-supplemented group was significantly better than that in the control group at ages 6 , 17 , 26 , and 52 wk . Stereoacuity in the LCP-supplemented group was significantly better than that in the control group at age 17 wk but not at ages 39 and 52 wk . By ages 17 and 39 wk , the red blood cell DHA concentration in the LCP-supplemented group was more than double and more than triple , respectively , that in the control group . Growth of infants fed LCP-supplemented and control formulas did not differ significantly , and both diets were well tolerated . CONCLUSION LCP supplementation of term infant formula during the first year of life yields clear differences in visual function and in total red blood cell lipid composition
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .