“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .
Prospective evaluation of the effect of statins on blood pressure control in hypertensive patients in clinical practice.
BACKGROUND AND AIM Some clinical evidence supports a statin antihypertensive effect . Our aim is to evaluate the statin effect on blood pressure control in hypertensive patients in the setting of clinical practice , and the role of some predetermined individual patient characteristics ( age , gender , baseline BP levels , pre-treatment LDL-C levels ) on the supposed statin BP lowering effect . METHODS AND RESULTS Two hundred and fifty-four hypertensive patients with hypercholesterolemia were enrolled in the Ambulatory service of the Hypertension Research Unit of Bologna University Hospital . After 2 - 4 weeks of a run-in period patients were allocated to statin treatment and followed-up for 24 weeks . The blood pressure response to statins was compared in several subgroups of patients according to age , gender , baseline BP and pre-treatment cholesterolemia . In the overall study population , the use of statins was associated with a significant reduction in systolic ( -7.6+/-4 mmHg , p<0.05 ) and diastolic blood pressures ( -5.2+/-3 mmHg , p<0.05 ) in comparison to baseline . The blood pressure decrease was more pronounced in patients younger than 65 years ( p<0.05 ) , with higher baseline systolic blood pressure ( p<0.005 ) , and in those with higher cholesterolemia before statins ( p<0.05 ) . CONCLUSIONS Our study suggests a BP-lowering effect of statins , consistent with some other literature . Some parameters like age , baseline systolic blood pressure and cholesterolemia influence the antihypertensive effect of statins . The lack of consideration for these confounding factors may be one of the reasons for the conflicting results about the BP lowering effects of statins
“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .