The vast majority of studies reported inverse associations between 25(OH)D concentration and all-cause mortality .
This association appeared to be non-linear , with progressively lower mortality with increasing 25(OH)D up to a point , beyond which there was no further decrease .
There is moderate evidence that vitamin D status is inversely associated with cancer mortality and death due to respiratory diseases , while for cardiovascular mortality , there is weak evidence of an association in observational studies , which is not supported by the data from intervention or Mendelian r and omization studies .
Epidemiological evidence suggests that vitamin D deficiency is associated with increased mortality , but it is unclear whether this is explained by reverse causation , and if there are specific causes of death for which vitamin D might be important .
Total 25-Hydroxyvitamin D Concentration as a Predictor for All-Cause Death and Cardiovascular Event Risk among Ethnic Chinese Adults: A Cohort Study in a Taiwan Community
Background Evidence of an inverse association between serum  25-hydoroxyvitamin D [ 25(OH)D ] and the risk of all-cause death and cardiovascular disease from prospect i ve studies is inconsistent . We tested the relationship between 25(OH)D and the risk among adult ethnic Chinese in Taiwan . Methods We conducted a community-based cohort study of 1816 participants ( age 60.2±10.2 yrs , 45.0 % women ) in the Chin-Shan Community Cardiovascular Cohort Study who were free of cardiovascular diseases at baseline and provided 25(OH)D measurements . Results During a median 9.6 ( interquartile range , 8.8- 10.5 ) years ’ follow-up period , totally 263 cases developed cardiovascular death events and 559 participants were documented to death from any cause . As 25(OH)D concentration increased , the incidence rates of cardiovascular events and all-cause death decreased progressively . 25(OH)D was inversely associated with all-cause death : the adjusted hazard ratio was 0.49 ( 95 % confidence interval [ CI ] , 0.25 - 0.97 ) for the third quartile and a significant J-shape relationship was found . The performance measures by integrated discriminative improvement showed significant improvement after adding 25(OH)D information ( 0.14 % , 95 % CI , 0.03 - 0.31 , P=0.050 , for all-cause death and 0.32 % , 95 % CI , 0.02 - 0.62 , P=0.018 for cardiovascular events ) . Conclusion These findings suggested a modest inverse association between 25(OH)D and the risk of all-cause death among diabetic participants and a good predictive factor in the community . Further studies to investigate the mechanism of vitamin D role on health effect are warranted
The vast majority of studies reported inverse associations between 25(OH)D concentration and all-cause mortality .
This association appeared to be non-linear , with progressively lower mortality with increasing 25(OH)D up to a point , beyond which there was no further decrease .
There is moderate evidence that vitamin D status is inversely associated with cancer mortality and death due to respiratory diseases , while for cardiovascular mortality , there is weak evidence of an association in observational studies , which is not supported by the data from intervention or Mendelian r and omization studies .
Epidemiological evidence suggests that vitamin D deficiency is associated with increased mortality , but it is unclear whether this is explained by reverse causation , and if there are specific causes of death for which vitamin D might be important .