Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
A 250 μg/week dose of vitamin D was as effective as a 50 μg/d dose in healthy adults, but a regimen of four weekly followed by monthly doses of 1250 μg raised the risk of hypercalciuria.
The risk of vitamin D insufficiency is increased in persons having limited sunlight exposure and dietary vitamin D. Supplementation compliance might be improved with larger doses taken less often , but this may increase the potential for side effects . The objective of the present study was to determine whether a weekly or weekly/monthly regimen of vitamin D supplementation is as effective as daily supplementation without increasing the risk of side effects . Participants were forty-eight healthy adults who were r and omly assigned for 3 months to placebo or one of three supplementation regimens : 50 μg/d ( 2000 IU/d , analysed dose 70 μg/d ) , 250 μg/week ( 10 000 IU/week , analysed dose 331 μg/week ) or 1250 μg/week ( 50 000 IU/week , analysed dose 1544 μg/week ) for 4 weeks and then 1250 μg/ month for 2 months . Daily and weekly doses were equally effective at increasing serum 25-hydroxyvitamin D , which was significantly greater than baseline in all the supplemented groups after 30 d of treatment . Subjects in the 1250 μg treatment group , who had a BMI > 26 kg/m2 , had a steady increase in urinary Ca in the first 3 weeks of supplementation , and , overall , the relative risk of hypercalciuria was higher in the 1250 μg group than in the placebo group ( P=0·01 ) . Although vitamin D supplementation remains a controversial issue , these data document that supplementing with ≤ 250 mg/week ( ≤ 10 000 IU/week ) can improve or maintain vitamin D status in healthy population s without the risk of hypercalciuria , but 24 h urinary Ca excretion should be evaluated in healthy persons receiving vitamin D3 supplementation in weekly single doses of 1250 μg ( 50 000 IU )
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .