Results from the meta-regression approach showed an inverse relation between cardiovascular risks and BMI reduction .
Conclusions The present study showed an overall reduction of cardiovascular risk after bariatric surgery .
In summary , our study showed that laparoscopic bariatric surgery is an effective therapeutic option to reduce the cardiovascular risk in severe obese patients
Background This study aims to evaluate the 12–24-month impact of bariatric surgery on the foremost modifiable traditional risk factors of cardiovascular disease .
Subgroup analyses of the major clinical endpoints in the Program on the Surgical Control of the Hyperlipidemias (POSCH): overall mortality, atherosclerotic coronary heart disease (ACHD) mortality, and ACHD mortality or myocardial infarction.
The Program on the Surgical Control of the Hyperlipidemias ( POSCH ) was a secondary atherosclerosis intervention trial employing partial ileal bypass surgery as the intervention modality . For this report , we analyzed 105 subgroups in 35 variables in POSCH , chosen predominantly for their potential relationship to the risk of atherosclerotic coronary heart disease ( ACHD ) . We defined potential differential effects as those with : ( 1 ) an absolute z-value > or = 2.0 for the subgroup , if the absolute z-value for the overall effect was < 2.0 ; and ( 2 ) an absolute z-value > or = 3.0 for the subgroup and a relative risk < or = 0.5 , if the absolute z-value for the overall effect was > or = 2.0 . For each of three major POSCH endpoints of overall mortality , ACHD mortality and ACHD mortality or confirmed nonfatal myocardial infa rct ion , we found seven subgroups with a differential risk reduction in the surgery group as compared to the control group . Allowing for identical subgroups for more than one endpoint , there were 13 individual subgroups with differential effects . Of these , seven demonstrated internal consistency across endpoints , and five of these seven displaced external consistency with known ACHD risk factors and for biological plausibility : triglyceride concentration > or = 200 mg/dl ; cigarette smoking ; overt or borderline diabetes mellitus ; a Minnesota ECG Q-QS code of 1 - 1 ; and obesity . A greater risk reduction , in comparison to the overall treatment effect , by the reduction of a single risk factor , hypercholesterolemia , in patients with at least two major ACHD risk factors was a provocative and an hypothesis-generating outcome of this analysis . The clinical implication s of this finding may lead to more aggressive cholesterol intervention in patients with multiple ACHD risk factors
Results from the meta-regression approach showed an inverse relation between cardiovascular risks and BMI reduction .
Conclusions The present study showed an overall reduction of cardiovascular risk after bariatric surgery .
In summary , our study showed that laparoscopic bariatric surgery is an effective therapeutic option to reduce the cardiovascular risk in severe obese patients
Background This study aims to evaluate the 12–24-month impact of bariatric surgery on the foremost modifiable traditional risk factors of cardiovascular disease .