Vitamin K supplementation did not affect insulin sensitivity as measured by homeostasis model assessment of insulin resistance , fasting plasma glucose , fasting plasma insulin , C-reactive protein , adiponectin , leptin , and interleukin-6 levels .
Our analysis suggests no effect of vitamin K supplementation on insulin sensitivity
OBJECTIVE To perform a systematic review and meta- analysis of r and omized , placebo-controlled trials to assess the effect of vitamin K supplementation on insulin sensitivity .
The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial
Background / Objectives : A relationship between osteocalcin ( OC ) levels and factors associated with energy metabolism and insulin resistance has been reported recently . The aim of this study was to investigate whether modulation of ostecalcin isoforms via vitamin K1 supplementation would affect glucose metabolism or insulin sensitivity in prediabetic and premenopause women . Subjects/ Methods : Eighty-two prediabetic women were r and omized to consume vitamin K1 supplement ( n=39 ) or placebo ( n=43 ) for 4 weeks . Participants in the vitamin K1 supplement group received one pearl softgel capsule containing 1000 μm of phylloquinone , and the placebo group received one placebo capsule daily for 4 weeks . Blood sample s were collected at baseline and after the 4-week intervention period to quantify carboxylated OC ( cOC ) , undercarboxylated OC ( ucOC ) and relevant variables . Results : Phylloquinone supplementation increased the serum levels of cOC and decreased ucOC , compared with placebo ( 12.53±5.95 compared with 7.43±4.85 ng/ml and 2.47±1.91 compared with 4.79±2.43 ng/ml , respectively ; P<0.001 ) . Furthermore , intake of phylloquinone supplement led to significant decreases in % ucOC ( 17.97±12.24 compared with 43.80±19.86 ) and 2-h post-oral glucose tolerance test ( OGTT ) glucose ( 7.32±1.50 compared with 8.62±1.45 mmol/l ) , and 2- h post-OGTT insulin level ( 80.34±42.24 compared with 112.43±53.19 μIU/ml ) and increased insulin sensitivity index ( 2.46±0.71 compared with 1.75±0.61 ) compared with placebo . Overall , a significant association was found between changes in % ucOC and changes in 2-h post-OGTT glucose ( r=0.308 , P=0.028 ) . Conclusions : The results of this study demonstrated that vitamin K1 supplementation for 4 weeks did not affect insulin resistance in premenopausal and prediabetic women but had beneficial effects on glycemic status and insulin sensitivity
Vitamin K supplementation did not affect insulin sensitivity as measured by homeostasis model assessment of insulin resistance , fasting plasma glucose , fasting plasma insulin , C-reactive protein , adiponectin , leptin , and interleukin-6 levels .
Our analysis suggests no effect of vitamin K supplementation on insulin sensitivity
OBJECTIVE To perform a systematic review and meta- analysis of r and omized , placebo-controlled trials to assess the effect of vitamin K supplementation on insulin sensitivity .