The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis.
A 6-month double-blind , controlled clinical study was completed with 124 healthy adult subjects to determine the efficacy of 2 mouthrinses , Listerine ( LA ) and Peridex ( PX ) , used as supplements to regular oral hygiene measures in reducing supragingival dental plaque and gingivitis . Following screening examinations for entry levels of existing gingivitis and plaque , baseline gingival and plaque area indices , extrinsic tooth stain , supragingival calculus , bleeding and soft tissue condition were recorded . All subjects then received a complete dental prophylaxis to remove plaque , calculus and extrinsic stain . Subjects were r and omly assigned to 1 of 3 groups and performed supervised rinses twice daily for 30 s in addition to their normal oral hygiene , for 6 months . All indices were again evaluated at 3 and 6 months . After 6 months , LA and PX significantly ( p less than 0.001 ) inhibited development of plaque by 36.1 % and 50.3 % , respectively , and the development of gingivitis by 35.9 % and 30.5 % , respectively , compared to a hydroalcohol control . PX was more effective in inhibiting plaque and both mouthrinses appeared to be equally effective in inhibiting gingivitis . LA patients did not develop significant levels of stain or supragingival calculus at 6 months , compared to baseline or control . PX patients developed significant levels of extrinsic stain and supragingival calculus compared to baseline and control . Though PX was more effective than LA in the control of plaque , this study indicates that both LA and PX were effective agents in a regimen for the control of plaque and gingivitis
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .