For studies of a similar design and which assessed the same outcomes in similar population groups , we report the potential for the combining of data across studies in systematic review s. CONCLUSIONS This scoping review has revealed the extensive evidence base for many outcomes which could be the focus of systematic review s exploring the health effects of conventional yogurt consumption
BACKGROUND The health effects of conventional yogurt have been investigated for over a century ; however , few systematic review s have been conducted to assess the extent of the health benefits of yogurt .
OBJECTIVE The aim of this scoping review was to assess the volume of available evidence on the health effects of conventional yogurt .
A Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells
Background : Hyperlipidemia and obesity are associated with metabolic syndrome and increased risk in developing diabetes and cardiovascular disease . Nutritional supplements , e.g. L-carnitine and polyunsaturated fatty acids ( PUFAs ) , exert lipid-lowering effects . Hence , the hypothesis that dietetic intervention reduces plasma lipid levels and metabolic enzymes in overweight hyperlipidemic subjects was tested . Subjects and Methods : In a prospect i ve placebo-controlled double-blind study in 22 moderately hyperlipidemic obese humans consuming low-fat yoghurt enriched with a combination of low-dose PUFAs , polyphenols and L-carnitine ( PPC ) twice a day for 12 weeks were compared to 20 matching participants ingesting low-fat yoghurt .  The effects on plasma lipids and expression of enzymes involved in regulation of fatty acid oxidation in peripheral blood mononuclear cells ( P BMC s ) and HepG2 cells were evaluated . Results : PPC consumption led to significantly reduced plasma free fatty acid ( –29 % ) and triglyceride ( –24 % ) concentrations ( each p < 0.05 ) . PPC application increased significantly peroxisome proliferator-activated receptor α ( PPARα ) mRNA abundances and those of PPARα target genes ( carnitine palmitoyltransferases-1 , CPT1A and CPT1B , carnitine acetyltransferase and organic cation transporter 2 ; each p < 0.05 ) in P BMC s. In controls , plasma lipid levels and P BMC gene expression did not change . These findings were substantiated by the results of cell culture experiments in HepG2 cells . Conclusion : Supplementation of PPC  had marked lipid-lowering effects and P BMC gene expression profiles seemed to reflect nutrition-related metabolic changes
For studies of a similar design and which assessed the same outcomes in similar population groups , we report the potential for the combining of data across studies in systematic review s. CONCLUSIONS This scoping review has revealed the extensive evidence base for many outcomes which could be the focus of systematic review s exploring the health effects of conventional yogurt consumption
BACKGROUND The health effects of conventional yogurt have been investigated for over a century ; however , few systematic review s have been conducted to assess the extent of the health benefits of yogurt .
OBJECTIVE The aim of this scoping review was to assess the volume of available evidence on the health effects of conventional yogurt .