Conclusions PDE5Is were significantly more effective than placebo or SSRIs for treating PE , while SSRIs were better than placebo .
The combined treatment had better efficacy than PDE5Is or SSRIs alone
Purpose To clarify the efficacy of phosphodiesterase-5 inhibitors ( PDE5Is ) and selective serotonin reuptake inhibitors ( SSRIs ) in men with premature ejaculation ( PE ) .
Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation.
OBJECTIVES To compare the efficacy of sildenafil ( Viagra ) only , sildenafil plus topical anesthetic cream ( EMLA ) , and topical EMLA-cream-only to that of placebo in treating  premature ejaculation .  METHODS A total of 84 patients were enrolled in this study . The duration of premature ejaculation in the patients ranged from 9 to 60 months ( mean 32.5 + /- 14.6 ) . Patients were r and omized into four groups . Group 1 consisted of 20 patients who took placebo for 2 months . Groups 2 and 3 consisted of 20 and 22 patients , respectively , and they received 50 mg sildenafil 45 minutes before coitus for 2 months . In addition , patients in group 3 applied topical EMLA cream to the glans penis 15 minutes before coitus . The 22 patients in group 4 used topical EMLA-cream-only . After at least eight sexual attempts , the patients ' clinical responses were assessed using the patient self-description method . Effectiveness was described as improvement plus cure . RESULTS The effectiveness was 40 % in group 1 , 55 % in group 2 , 86.4 % in group 3 , and 77.3 % in group 4 . Of the groups , a significant difference was found in the effectiveness of the treatments ( Pearson chi-square= 0.00 ) . No significant difference was found between groups 1 and 2 ( P = 0.26 ) . Efficacy was more successful in groups 3 and 4 than in the others ( P = 0.00 ) . The difference between groups 3 and 4 was not significant ( Pearson chi-square = 0.42 ) . CONCLUSIONS Sildenafil-only was not superior to placebo or combination treatment . Topical EMLA-cream-only had equal effectiveness to that of sildenafil plus topical EMLA treatment . The use of topical EMLA-cream-only seems to be an effective treatment of premature ejaculation
Conclusions PDE5Is were significantly more effective than placebo or SSRIs for treating PE , while SSRIs were better than placebo .
The combined treatment had better efficacy than PDE5Is or SSRIs alone
Purpose To clarify the efficacy of phosphodiesterase-5 inhibitors ( PDE5Is ) and selective serotonin reuptake inhibitors ( SSRIs ) in men with premature ejaculation ( PE ) .