The testosterone and control groups demonstrated no significant difference for other outcomes .
In conclusion , we found that TRT can improve glycemic control and decrease triglyceride levels of hypogonadal men with T2DM .
This systematic review was aim ed at assessing the metabolic effects of testosterone replacement therapy ( TRT ) on hypogonadal men with type 2 diabetes mellitus ( T2DM ) .
Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism.
CONTEXT Evidence suggests that testosterone ( T ) influences insulin sensitivity in men . The mechanism of this effect is unclear but is thought to involve changes in body composition . OBJECTIVE The aim of this study was to determine whether acute sex steroid withdrawal decreases insulin sensitivity in young , healthy men with idiopathic hypogonadotropic hypogonadism ( IHH ) . DESIGN This was a 2-wk prospect i ve study . SETTING The study was conducted at a General Clinical Research Center . PATIENTS Twelve men with IHH ( age 40.8 + /- 2.8 yr ) were studied : 1 ) on hormone replacement with normal T levels and 2 ) 2 wk after discontinuing therapy . MAIN OUTCOME MEASURES Each evaluation comprised a 75-g oral glucose tolerance test with assessment of insulin sensitivity ( fasting insulin levels , homeostatic model assessment for insulin resistance , and Matsuda insulin sensitivity index ) and insulin secretion ( corrected insulin response ) . Serum cortisol , leptin , adiponectin , free fatty acids , IL-6 , C-reactive protein , and TNF-alpha levels were also measured . RESULTS Body mass index was unchanged ( 27.1 + /- 1.1 to 27.2 + /- 1.1 kg/m(2 ) ) . Serum T levels decreased from 529 + /- 65 to 28 + /- 8 ng/dl ( P < 0.00005 ) . Fasting insulin levels increased from 4.9 + /- 0.7 to 6.2 + /- 0.6 microU/ml ( P = 0.005 ) , homeostatic model assessment of insulin resistance increased from 1.07 + /- 0.2 to 1.4 + /- 1.01 ( P < 0.005 ) , and insulin sensitivity index decreased from 11.0 + /- 2.3 to 7.5 + /- 0.7 ( P < 0.05 ) . There was a trend for fasting glucose levels to increase , 86.7 + /- 1.3 to 90.8 + /- 1.7 mg/dl ( P = 0.09 ) . IL-6 levels increased from 1.2 + /- 0.2 to 2.4 + /- 0.5 pg/ml ( P < 0.01 ) , whereas TNF-alpha levels decreased from 1.0 + /- 0.1 to 0.6 + /- 0.1 pg/ml ( P < 0.05 ) . No other significant changes were observed . CONCLUSIONS 1 ) Acute sex steroid withdrawal reduces insulin sensitivity in young healthy IHH men . 2 ) The acuity of the hypogonadism and absence of changes in body mass index or leptin levels suggest that sex steroids modulate insulin sensitivity in the absence of apparent or detectable changes in body composition
The testosterone and control groups demonstrated no significant difference for other outcomes .
In conclusion , we found that TRT can improve glycemic control and decrease triglyceride levels of hypogonadal men with T2DM .
This systematic review was aim ed at assessing the metabolic effects of testosterone replacement therapy ( TRT ) on hypogonadal men with type 2 diabetes mellitus ( T2DM ) .