Conclusions : This systematic review and meta- analysis indicate that PDE5 inhibitors are effective and well tolerated to treat ED secondary to SCI compared with placebo , as measured by response to GEQ , SEP2 , SEP3 and incidence of adverse events .
PDE5 inhibitors could be considered as the first choice in the treatment of ED patients with SCI
Study design : Systemic review Objective : We carried out a systematic review and meta- analysis to assess the efficacy and safety of phosphodieterase-5 ( PDE5 ) inhibitors on erectile dysfunction ( ED ) secondary to spinal cord injury ( SCI ) .
Percutaneous Perineal Electrostimulation Induces Erection: Clinical Significance in Patients With Spinal Cord Injury and Erectile Dysfunction
Abstract Objectives : Approximately one third to one half of the penis is embedded in the pelvis and can be felt through the scrotum and in the perineum . The main arteries and nerves enter the penis through this perineal part of the penis , which seems to represent a highly sensitive area . We investigated the hypothesis that percutaneous perineal stimulation evokes erection in patients with neurogenic erectile dysfunction . Methods : Percutaneous electrostimulation of the perineum ( PESP ) with synchronous intracorporeal pressure ( ICP ) recording was performed in 28 healthy volunteers ( age 36.3 ± 7.4 y ) and 18 patients ( age 36.6 ± 6.8 y ) with complete neurogenic erectile dysfunction ( NED ) . Current was delivered in a sine wave summation fashion . Average maximal voltages and number of stimulations delivered per session were 15 to 18 volts and 15 to 25 stimulations , respectively . Results : PESP of healthy volunteers effected an ICP increase ( P < 0.0001 ) , which returned to the basal value upon stimulation cessation . The latent period recorded was 2.5 ± 0.2 seconds . Results were reproducible on repeated PESP in the same subject but with an increase of the latent period . Patients with NED recorded an ICP increase that was lower ( P < 0.05 ) and a latent period that was longer ( P < 0.0001 ) than those of healthy volunteers . Conclusion : PESP effected ICP increase in the healthy volunteers and patients with NED .  The ICP was significantly higher and latent period shorter in the healthy volunteers than in the NED patients . PESP may be of value in the treatment of patients with NED , provided that further studies are performed to reproduce these results
Conclusions : This systematic review and meta- analysis indicate that PDE5 inhibitors are effective and well tolerated to treat ED secondary to SCI compared with placebo , as measured by response to GEQ , SEP2 , SEP3 and incidence of adverse events .
PDE5 inhibitors could be considered as the first choice in the treatment of ED patients with SCI
Study design : Systemic review Objective : We carried out a systematic review and meta- analysis to assess the efficacy and safety of phosphodieterase-5 ( PDE5 ) inhibitors on erectile dysfunction ( ED ) secondary to spinal cord injury ( SCI ) .