Insulin mediated inhibition of lipolysis was decreased in patients , reflected by increased non-esterified fatty acid levels .
Insulin resistance is a prominent feature of patients with type 1 diabetes mellitus and involves hepatic , peripheral and adipose tissues
OBJECTIVE The aim of this study was to perform a systematic review and meta- analysis on insulin resistance in adult patients with type 1 diabetes mellitus compared to healthy controls , assessed by hyperinsulinemic euglycemic clamp studies .
Differential effect of chronic treatment with two beta‐blocking agents on insulin sensitivity: the carvedilol‐metoprolol study
Background Hypertensive patients frequently show resistance to insulin-stimulated glucose uptake and hyperinsulinemia . Diuretics and β-adrenoceptor blocking agents have been found to decrease insulin sensitivity , whereas α1-blockers and angiotensin converting enzyme inhibitors seem to improve it . Objective To compare the effects of a 3 months ' antihypertensive treatment with carvedilol , a non-selective β-adrenoceptor blocker with α1-blocking properties , with the β1-selective receptor blocker metoprolol on insulin sensitivity in non-diabetic hypertensive patients . Design A multicenter double-blind r and omized study . Subjects and methods Seventy-two non-diabetic hypertensive patients were r and omly assigned to treatment with either carvedilol or metoprolol . An isoglycemic , hyperinsulinemic glucose clamp was conducted before and after 12 weeks of treatment ; the metabolic clearance rate for glucose was taken as an indicator of insulin sensitivity . Results The two groups did not differ in age , sex , body mass index , blood pressure or lipids , and treatment effectively lowered blood pressure . In both groups , insulin sensitivity was impaired at baseline . After metoprolol treatment , insulin sensitivity further decreased significantly by about 14 % , whereas it increased after carvedilol . There was also a decrease in high-density lipoprotein and an increase in triglycerides levels in patients in the metoprolol-treated group , whereas these parameters remained unchanged in patients in the carvedilol-treated group . Conclusion This study confirms previous findings of a reduction in insulin sensitivity after chronic metoprolol treatment . Carvedilol treatment , however , result ed in a slight increase in insulin resistance and a better lipid profile . We thus demonstrate that a β-blocker with α1-blocking properties has favorable effects on glucose metabolism , suggesting a potentially important role of peripheral blood flow in regulating glucose uptake . These findings imply that β-blocker treatment , when combined with α1-blocking activity has advantageous effects on insulin sensitivity and lipids and could therefore be suitable for patients with the metabolic syndrome
Insulin mediated inhibition of lipolysis was decreased in patients , reflected by increased non-esterified fatty acid levels .
Insulin resistance is a prominent feature of patients with type 1 diabetes mellitus and involves hepatic , peripheral and adipose tissues
OBJECTIVE The aim of this study was to perform a systematic review and meta- analysis on insulin resistance in adult patients with type 1 diabetes mellitus compared to healthy controls , assessed by hyperinsulinemic euglycemic clamp studies .