In the case of the majority of studied drugs , an increased absorption rate was observed early after RYGBP .
The effect on systemic exposure allows for a low degree of extrapolation , including between drugs subjected to the same major metabolic and transporter pathways .
Anatomical changes in the gastrointestinal tract and subsequent weight loss may influence drug disposition and thus drug dosing following bariatric surgery .
This review systematic ally examines the effects of bariatric surgery on drug pharmacokinetics , focusing especially on the mechanisms involved in restricting oral bioavailability .
Biological effects of a new and potent progestagen. A clinical study.
The biological effects of a new synthetic progestagen , Org 2969 ( 13-ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol ) were studied in healthy normally menstruating women . Two of them were given 0.125 mg , five 0.060 mg and two 0.030 mg of Org 2969 daily on days 1 - 20 during one menstrual cycle . Serum levels of follicle stimulating hormone , luteinizing hormone , progesterone and oestradiol were analyzed on days 8 - 23 in order to evaluate the function of the hypophyseal-ovarian axis . The serum concentrations of aspartate amino transferase , alanine amino transferase , alkaline phosphatase , gamma glutamyl transpeptidase and bilirubin were determined to evaluate possible side effects on live function on days 8 , 15 and 23 . Serum cortisol was measured on days 8 and 23 . The basal body temperature was recorded daily during the whole cycle , and endometrium biopsies were taken on days 21 or 22 of the cycle . All sample s were taken similaryl during the treatment cycle and the preceding control cycle . According to the hormone determinations , all the treatment cycles were anovulatory except in one woman receiving the lowest dose . The treatment led to decreased spinnbarkeit , arborization and sperum penetration in the cervical mucus . Liver function tests and serum cortisol remained unchanged during the treatment
In the case of the majority of studied drugs , an increased absorption rate was observed early after RYGBP .
The effect on systemic exposure allows for a low degree of extrapolation , including between drugs subjected to the same major metabolic and transporter pathways .
Anatomical changes in the gastrointestinal tract and subsequent weight loss may influence drug disposition and thus drug dosing following bariatric surgery .
This review systematic ally examines the effects of bariatric surgery on drug pharmacokinetics , focusing especially on the mechanisms involved in restricting oral bioavailability .