( S ) Few studies of medical therapies for endometriosis report outcomes that are relevant to patients , and many women gain only limited or intermittent benefit from treatment
OBJECTIVE To assess patient response rates to medical therapies used to treat endometriosis-associated pain .
Danazol in the treatment of endometriosis: analysis of 100 cases with a 4-year follow-up.
A prospect i ve study to evaluate the efficacy of danazol in the treatment of endometriosis was initiated in 1976 . One hundred patients with endometriosis , as demonstrated by laparoscopy , were entered into the study . The mean length of patient follow-up was 49 months . All patients were treated with 800 mg of danazol per day . The mean duration of danazol therapy was 17.3 weeks . Eighty-nine percent of the patients reported symptomatic improvement , and 94 % were improved , as demonstrated by repeat laparoscopy or laparatomy . After completing a course of danazol therapy , 57 % of the patients underwent conservative laparotomy for fertility enhancement , pain control , or ovarian masses . Two patients underwent total abdominal hysterectomy-bilateral salpingo-oophorectomy for advanced disease poorly responsive to danazol therapy . In those patients desiring fertility ( 56 ) , there were 38 pregnancies in 26 women , for an overall fertility rate of 46 % . The overall recurrence rate was 33 % , as determined by symptoms and physical findings . Significant side effects from danazol were reported by 85 % of the patients . The major side effects were weight gain , edema , decrease in breast size , oily skin , hirsutism , and deepening of the voice . Only one patient discontinued danazol therapy due to side effects . Clinical tissues concerning the use of danazol with or without surgery and the miscarriage rate following danazol therapy are discussed
( S ) Few studies of medical therapies for endometriosis report outcomes that are relevant to patients , and many women gain only limited or intermittent benefit from treatment
OBJECTIVE To assess patient response rates to medical therapies used to treat endometriosis-associated pain .