Once-daily dihydropyridine calcium channel blockers appeared to lower blood pressure by a relatively constant amount throughout the 24-hour dosing interval .
Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours .
BACKGROUND Calcium channel blockers are a heterogeneous class of drugs , including dihydropyridine and non-dihydropyridine subgroups , commonly used in the treatment of hypertension .
A systematic review of the 24-hour time course of the blood pressure-lowering effect has not been published .
OBJECTIVES To assess how much variation there is in hourly systolic and diastolic blood pressure lowering by dihydropyridine calcium channel blockers over a 24-hour period in people with hypertension aged 18 years or over , with baseline systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg , or both .
Effect of Low-Dose Manidipine on Ambulatory Blood Pressure in Very Elderly Hypertensives
Summary . To evaluate the effect of manidipine 10 mg on 24-hour ambulatory blood pressure ( BP ) and heart rate ( HR ) in very elderly hypertensive patients , 54 patients aged 76–89 years ( mean age 81.8 years ) with systolic blood pressure ( SBP ) > 160 mmHg and diastolic blood pressure ( DBP ) > 90 mmHg were studied . After a 4-week placebo washout period , patients were r and omized to receive manidipine 10 mg or placebo , both administered once daily for 8 weeks . Patients were checked after the initial run-in placebo phase and every 4 weeks thereafter . At each visit casual BP and HR were measured . At the end of the placebo period and after 8 weeks of active treatment , noninvasive 24-hour ambulate blood pressure measurement ABPM was performed . Manidipine significantly lowered casual sitting and st and ing SBP ( P < 0.001 ) and DBP ( P < 0.001 ) at the trough level . ABPM showed a significant decrease in 24-hour SBP and DBP values ( P < 0,001 ) , daytime SBP and DBP ( P < 0.001 ) , and night-time SBP ( P < 0.001 ) and DBP ( P < 0.005 ) . In addition , ABPM confirmed a consistent antihypertensive activity throughout the 24-hour dosing interval , without effect on the circadian BP profile . The trough/peak ratio was 0.67 for SBP and 0.59 DBP . No statistically significant change in HR was observed . The treatment was well tolerated , and there were no serious side effects . In conclusion , in very elderly hypertensive patients , once-daily administration of manidipine 10 mg was well tolerated and effective in reducing casual as well ambulatory BP
Once-daily dihydropyridine calcium channel blockers appeared to lower blood pressure by a relatively constant amount throughout the 24-hour dosing interval .
Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours .
BACKGROUND Calcium channel blockers are a heterogeneous class of drugs , including dihydropyridine and non-dihydropyridine subgroups , commonly used in the treatment of hypertension .
A systematic review of the 24-hour time course of the blood pressure-lowering effect has not been published .
OBJECTIVES To assess how much variation there is in hourly systolic and diastolic blood pressure lowering by dihydropyridine calcium channel blockers over a 24-hour period in people with hypertension aged 18 years or over , with baseline systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg , or both .