Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .
The efficacy of cefazolin in reducing surgical site infection in laparoscopic cholecystectomy: a prospective randomized double-blind controlled trial
Background A prophylactic antibiotic is recommended in open cholecystectomy surgeries , but in laparoscopic cholecystectomies such prophylaxis is controversial . Recent review s have not found conclusive evidence that routine prophylaxis , especially in low risk patients , is effective . This clinical trial was undertaken to evaluate the efficacy of cefazolin in reducing surgical site infection SSI in laparoscopic cholecystectomies in a sample not screened for high or low risk patients . Methods A r and omized double-blind controlled trial was conducted in a single university hospital . Scheduled cholecystectomy patients without selection for patient risk factors were r and omized into two groups . Pre-operatively , group A patients received a placebo of 10 ml isotonic sodium chloride , and group B patients received 1 g of cefazolin as a prophylactic antibiotic . All patients underwent a st and ard laparoscopic cholecystectomy , and were followed up for at least 30 days . Results Two hundred ninety-nine patients were r and omized ( 149 in group A and 150 in group B ) .  SSI occurred in seven patients ( 2.34 % ) , five ( 1.67 % ) in the placebo group , and two ( 0.67 % ) in the prophylactic antibiotic group . The difference was not statistically significant ( p value = 0.512 ) , and no specific risk factors for post-operative infection were identified . Conclusions A single dose of preoperative prophylactic cefazolin has no significant benefit in reducing the incidence of SSI in laparoscopic cholecystectomy . Whether or not to use a prophylactic depends on the individual patient , and the consideration of the attending surgeon
Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .