Although observational evidence suggests that concentrations of selenium , zinc , and iron are positively associated with iodine status , data from r and omized controlled trials fail to confirm this relationship .
Context The metabolism of thyroid hormones , which are essential for normal development , involves many proteins and enzymes .
It requires iodine as a key component but is also influenced by several other micronutrients , including selenium , zinc , iron , and vitamin A. Objective This systematic review was design ed to investigate the effect of micronutrient status and supplementation on  iodine status and thyroid hormone concentrations .
Anemia, Iron Deficiency and Iodine Deficiency among Nepalese School Children
Objectives To assess iodine and iron nutritional status among Nepalese school children . Methods A cross-sectional , community based study was conducted in the two districts , Ilam ( hilly region ) and Udayapur ( plain region ) of eastern Nepal . A total of 759 school children aged 6–13 y from different schools within the study areas were r and omly enrolled . A total of 759 urine sample s and 316 blood sample s were collected . Blood hemoglobin level , serum iron , total iron binding capacity and urinary iodine concentration was measured . Percentage of transferrin saturation was calculated using serum iron and total iron binding capacity values . Results The mean level of hemoglobin , serum iron , total iron binding capacity , transferrin saturation and median urinary iodine excretion were 12.29 ± 1.85 g/dl , 70.45 ± 34.46 μg/dl , 386.48 ± 62.48 μg/dl , 19.94 ± 12.07 % and 274.67 μg/L respectively . Anemia , iron deficiency and iodine deficiency ( urinary iodine excretion < 100 μg/L ) were present in 34.5 % , 43.4 % and 12.6 % children respectively . Insufficient urinary iodine excretion ( urinary iodine excretion < 100 μg/L ) was common in anemic and iron deficient children . Conclusions Iron deficiency and anemia are common in Nepalese children , whereas , iodine nutrition is more than adequate . Low urinary iodine excretion was common in iron deficiency and anemia
Although observational evidence suggests that concentrations of selenium , zinc , and iron are positively associated with iodine status , data from r and omized controlled trials fail to confirm this relationship .
Context The metabolism of thyroid hormones , which are essential for normal development , involves many proteins and enzymes .
It requires iodine as a key component but is also influenced by several other micronutrients , including selenium , zinc , iron , and vitamin A. Objective This systematic review was design ed to investigate the effect of micronutrient status and supplementation on  iodine status and thyroid hormone concentrations .