Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects.
OBJECTIVE High fat , low carbohydrate ( HFLC ) diets have become popular tools for weight management . We sought to determine the effects of a HFLC diet compared to a low fat high carbohydrate ( LFHC ) diet on the change in weight loss , cardiovascular risk factors and inflammation in subjects with obesity . METHODS Obese subjects ( 29.0 - 44.6 kg/m2 ) recruited from Boston Medical Center were r and omized to a hypocaloric LFHC ( n=26 ) or HFLC ( n=29 ) diet for 12 weeks . RESULTS The age range of subjects was 21 - 62 years . As a percentage of daily calories , the HFLC group consumed 33.5 % protein , 56.0 % fat and 9.6 % carbohydrate and the LFHC group consumed 22.0 % protein , 25.0 % fat and 55.7 % carbohydrate . The change in percent body weight , lean and fat mass , blood pressure , flow mediated dilation , hip : waist ratio , hemoglobin A1C , fasting insulin and glucose , and glucose and insulin response to a 2h oral glucose tolerance test did not differ ( P>0.05 ) between diets after 12 weeks . The HFLC group had greater mean decreases in serum triglyceride ( P=0.07 ) , and hs-CRP ( P=0.03 ) , and greater mean increases in HDL cholesterol ( P=0.004 ) , and total adiponectin ( P=0.045 ) relative to the LFHC . Secreted adipose tissue adiponectin or TNF-α did not differ after weight loss for either diet . CONCLUSIONS Relative to the LFHC group , the HFLC group had greater improvements in blood lipids and systemic inflammation with similar changes in body weight and composition . This small-scale study suggests that HFLC diets may be more beneficial to cardiovascular health and inflammation in free-living obese adults compared to LFHC diets
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .