Conclusions : Many of the children in the included studies were already stunted and may have been suffering from multiple micronutrient deficiencies , and therefore zinc supplementation alone may have only a limited effect on growth
Background / objectives : It is estimated that zinc deficiency affects 17 % of the world 's population , and because of periods of rapid growth children are at an increased risk of deficiency , which may lead to stunting .
This paper presents a systematic review and meta- analysis of the r and omised controlled trials ( RCTs ) that assess zinc intake and growth in children aged 1–8 years .
Zinc absorption as a function of the dose of zinc sulfate in aqueous solution.
BACKGROUND Zinc supplements are used extensively in medicine and research and for public health purpose s in the prevention and treatment of zinc deficiency . However , little is known about the efficiency of zinc utilization after different doses . OBJECTIVE The objective was to determine the relation between dose of aqueous zinc and absorbed zinc ( AZ ) in healthy adults . DESIGN Eight healthy adults ( 3 men and 5 women ) aged 33.8 + /- 9.8 y ( x + /- SD ) received 3 pairs of zinc doses ( 2 and 5 , 10 and 15 , and 20 and 30 mg ) in r and om order in 3 phases ( 1 pair per phase ) . There was a 3-wk washout between phases . Aqueous zinc sulfate labeled with 70Zn or 68Zn was orally administered in the postabsorptive state on days 1 and 6 , respectively ; intravenous 67Zn was administered 1 h after the first oral zinc dose . Two urine sample s were collected daily from days 3 to 15 ; zinc isotopic ratios were determined by inductively coupled plasma mass spectrometry . Fractional absorption of zinc ( FAZ ) was determined by dual-isotope-tracer ratio ; AZ was calculated by multiplying FAZ by dose . RESULTS Mean ( + /-SD ) AZ values at doses of 2.2 , 5.2 , 10.4 , 15.2 , 20.3 , and 30.1 mg ingested Zn were 1.6 + /- 0.4 , 3.5 + /- 1.3 , 7.4 + /- 1.0 , 9.5 + /- 2.2 , 11.0 + /- 4.4 , and 11.2 + /- 2.1 mg , respectively . A saturable dose-response model , the Hill equation , was selected to model the relation of AZ to ingested zinc . Parameter estimation by nonlinear regression predicted a maximum zinc absorption of 13 mg for larger doses . CONCLUSIONS Increases in aqueous zinc doses > 20 mg result in relatively small and progressively diminishing increases in AZ postabsorptively in healthy adults
Conclusions : Many of the children in the included studies were already stunted and may have been suffering from multiple micronutrient deficiencies , and therefore zinc supplementation alone may have only a limited effect on growth
Background / objectives : It is estimated that zinc deficiency affects 17 % of the world 's population , and because of periods of rapid growth children are at an increased risk of deficiency , which may lead to stunting .
This paper presents a systematic review and meta- analysis of the r and omised controlled trials ( RCTs ) that assess zinc intake and growth in children aged 1–8 years .