RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .
A comparison of the efficacy and duration of action of telmisartan, amlodipine and ramipril in patients with confirmed ambulatory hypertension
Objectives The aim of the study was to compare the antihypertensive effects and the duration of action of telmisartan , amlodipine and ramipril in patients with mild-to-moderate hypertension using ambulatory blood pressure ( ABP ) monitoring . Methods After a 2–4-week single-blind , placebo run-in period , qualifying patients were r and omized to receive telmisartan 80 mg ( n=18 ) ; amlodipine 5 mg ( n=22 ) ; titrated to 10 mg after 4 weeks ; or ramipril 2.5 mg ( n=17 ) ; titrated to 5 mg and 10 mg after 1 and 3 weeks , respectively , administered once daily in the morning ( 0700 h ) . Ambulatory blood pressure monitoring was performed at baseline and at the end of the 8-week treatment period . Plasma renin activity was measured over 24 h at the same time points . Results Telmisartan and amlodipine provided significant reductions from baseline ( P<0.0001 ) and not statistically different reductions between treatments in ABP during daytime ( 9.3/6.0 and 14.7/9.4 mmHg , respectively ) and night-time ( 12.4/7.7 and 13.3/8.6 mmHg , respectively ) at the end of 8 weeks ' treatment . In contrast , although ramipril provided significant reductions in ambulatory systolic and diastolic BP from 2–6 h post dose ( peak effect ) , it failed to induce significant reductions in mean daytime ( 4.5/1.6 mmHg ) and night-time ( 1.8/0.1 mmHg ) ambulatory BP . In addition , the greater reductions in ABP with telmisartan and amlodipine were associated with a significant rise in plasma renin activity whereas ramipril only increased renin during the first 4 h of the administration interval . Conclusion The results of the present study confirm the efficacy of both telmisartan and amlodipine in reducing ABP during each period of the 24-h interval . Because ABP reduction with ramipril was restricted to its peak effect , the present data do not support the use of this agent when administered once daily in the morning
RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .