Conclusions CB-2 tended to be more effective in comparison to NCF catheter and at least non-inferior to CF catheter , with shorter procedure time and similar safety endpoint
Purpose Currently , radiofrequency ( RF ) and cryoballoon are the most commonly used ablation technologies for atrial fibrillation ( AF ) .
We performed a meta- analysis to assess the efficacy and safety of the second-generation cryoballoons ( CB-2 ) compared with RF for paroxysmal atrial fibrillation ( PAF ) ablation .
The COR trial: a randomized study with continuous rhythm monitoring to compare the efficacy of cryoenergy and radiofrequency for pulmonary vein isolation.
BACKGROUND Results from r and omized trials design ed to compare cryoenergy with radiofrequency for pulmonary vein ( PV ) isolation are lacking . OBJECTIVE To compare the efficacy of a simplified strategy for PV cryoablation ( group C ) vs PV isolation with open-irrigated radiofrequency catheters ( group R ) . METHODS Fifty patients with paroxysmal atrial fibrillation ( AF ) and 4 independent PVs received a Reveal XT implantable cardiac monitor and were r and omized to group C or group R. In group C , PV ablation was done with a single A rct ic Front balloon ( 23 or 28 mm ) per patient and two 300-second applications per PV . No further applications were delivered to close residual conduction gaps . In group R , bidirectional PV conduction block was pursued with Lasso and Navistar ThermoCool catheters and the CARTO system . The primary end point was the proportion of patients remaining free from AF recurrences ≥2 minutes without taking antiarrhythmic drugs 12 months after ablation . RESULTS The primary end point was met by 12 ( 48 % ) patients in group C and 25 ( 68 % ) patients in group R ( odds ratio 0.43 ; P = .05 ) . This difference disappeared after adjustment for acute procedural outcome . In patients for whom all 4 PVs were blocked at the end of the procedure , there was no difference between group C and group R in the primary end point ( 67 % vs 68 % ; P = .94 ) . CONCLUSIONS The efficacy of the simplified strategy for PV cryoablation tested in this study is inferior to PV isolation using open-irrigated radiofrequency catheters with electrophysiological and electroanatomical guidance . Complete PV conduction block is critical to the success of AF ablation
Conclusions CB-2 tended to be more effective in comparison to NCF catheter and at least non-inferior to CF catheter , with shorter procedure time and similar safety endpoint
Purpose Currently , radiofrequency ( RF ) and cryoballoon are the most commonly used ablation technologies for atrial fibrillation ( AF ) .
We performed a meta- analysis to assess the efficacy and safety of the second-generation cryoballoons ( CB-2 ) compared with RF for paroxysmal atrial fibrillation ( PAF ) ablation .