Due to differences in modalities , time course , study design and outcomes , it is not possible to define a single ‘ physiological time window ’ for SRC recovery .
Multiple studies suggest physiological dysfunction may outlast current clinical measures of recovery , supporting a buffer zone of gradually increasing activity before full contact risk .
Aim or objective The aim of this study is to consoli date studies of physiological measures following sport-related concussion ( SRC ) to determine if a time course of postinjury altered neurobiology can be outlined .
This biological time course was considered with respect to clinical ly relevant outcomes such as vulnerability to repeat injury and safe timing of return to physical contact risk .
Serum Tau Fragments Predict Return to Play in Concussed Professional Ice Hockey Players.
The diagnosis of sports-related concussion is mainly based on subjective clinical symptoms and neuropsychological tests . Therefore , reliable brain injury biomarkers to assess when it is safe to return to play are highly desirable . The overall objective of this study was to evaluate the utility of two newly described tau fragments for diagnosis and prognosis of sports-related concussions . This multi-center prospect i ve cohort study involved all 12 teams of the top professional ice hockey league in Sweden . A total of 288 players consented to participate in the study . Thirty-five players sustained concussions , of whom 28 underwent repeated blood samplings at 1 , 12 , 36 , and 144 h after the trauma , or when the player returned to play ( 7 to > 90 days ) . There was no significant increase in the levels of Tau-A in post-concussion sample s compared with preseason values . However , serum levels of Tau-C were significantly higher in post-concussion sample s compared with preseason . Further , levels of Tau-A correlated with the duration of post-concussive symptoms . Tau-A in serum , which is newly discovered biomarker , could be used to predict when it is safe to return to play after a sports-related concussion
Due to differences in modalities , time course , study design and outcomes , it is not possible to define a single ‘ physiological time window ’ for SRC recovery .
Multiple studies suggest physiological dysfunction may outlast current clinical measures of recovery , supporting a buffer zone of gradually increasing activity before full contact risk .
Aim or objective The aim of this study is to consoli date studies of physiological measures following sport-related concussion ( SRC ) to determine if a time course of postinjury altered neurobiology can be outlined .
This biological time course was considered with respect to clinical ly relevant outcomes such as vulnerability to repeat injury and safe timing of return to physical contact risk .