They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .
Vitamin D supplementation trial in infancy: body composition effects at 3 years of age in a prospective follow‐up study from Montréal
BACKGROUND The impact of vitamin D status on body composition is not well understood . OBJECTIVES Evaluate how vitamin D supplementation in infancy affects body composition at 3 years of age . METHODS Double-blind r and omized trial of 132 , 1-month-old healthy , breastfed infants r and omly assigned to receive oral vitamin D3 supplements of 400 , 800 , 1200 or 1600 IU d-1 for 11 months . In the present analysis , 87 ( 66 % ) returned at 3 years of age .  Body composition was measured using dual-energy x-ray absorptiometry and  plasma 25-hydroxyvitamin D [ 25(OH)D ] concentrations by liquid chromatography t and em mass spectrometry . RESULTS Anthropometry , body composition , diet , activity and demographics were similar across dosage groups at 3 years . Mean 25(OH)D concentration from 1 month to 3 years was higher ( P < 0.001 ) in the 1200 IU group than 800 and 400 IU groups . Children with 25(OH)D concentrations above 75 nmol L-1 had lower fat mass ( ~450 g ; P = 0.049 ) . In multiple linear regression , mean 25(OH)D was associated with lean mass percent ( β = 0.06 ; CI : 0.00 , 0.12 ; P = 0.042 ) , fat mass ( β = -11.29 ; CI : -22.06 , -0.52 ; P = 0.048 ) and body fat percent ( β = -0.06 ; CI : -0.12 , -0.01 ; P = 0.045 ) . CONCLUSIONS Higher vitamin D status from infancy through to 3 years of age associates with leaner body composition
They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .