In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
In vivo dental plaque pH variation with regular and diet soft drinks.
PURPOSE Despite the presence or absence of artificial sweeteners in cola drinks , both regular and diet soft drinks still contain phosphoric and citric acid , which contributes to the total acidic challenge potential on enamel . The purpose of this study was to assess the plaque pH , in vivo , after a substrate challenge of diet and regular soft drinks . METHODS Seventeen subjects were recruited for this study . All subjects were between the ages of 12 and 15 and had at least 4 restored tooth surfaces present . The subjects were given consent by their parents and were asked to refrain from brushing for 48 hours prior to the study . At baseline , plaque pH was measured from 4 separate locations using touch electrode methodology . Each subject was then r and omly assigned to one of two groups . The first group was exposed to regular Coke followed by Diet Coke , while the second group was exposed to Diet Coke followed by regular Coke . Subjects were asked to swish with 15 ml of the respective soft drink for one minute . Plaque pH was measured at the 4 design ated tooth sites at 5- , 10- and 20-minute intervals . Subjects then repeated the experiment using the other soft drink . RESULTS The results showed that regular Coke had significantly more acidic plaque pH values at the 5- , 10- and 20-minute intervals compared to Diet Coke , ( P = < .001 ) , when subjected to a t test . The mean pH at 5 minutes for Coke and Diet Coke was 5.5 + /- 0.5 and 6.0 + /- 0.7 , respectively . At 10 minutes , the pH for Coke and Diet Coke was 5.6 + /- 0.6 and 6.2 + /- 0.7 , respectively . The pH at 20 minutes for Coke and Diet Coke was 5.7 + /- 0.7 and 6.5 + /- 0.5 , respectively . CONCLUSIONS These data suggest that regular Coke possesses a greater acid challenge potential on enamel than Diet Coke . However , in this clinical trial , the pH associated with either soft drink did not reach the critical pH which is expected for enamel demineralization and dissolution
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .