All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .
Independence and health related quality of life in 200 onco-geriatric surgical patients within 6 months of follow-up: Who is at risk to lose?
AIMS Comprehensive Geriatric Assessment ( CGA ) provides information on aspects of older patients to predict risks and benefits of interventions . METHODS To evaluate the application of CGA ( including quality of life ( QOL ) )  for the risk prediction of postoperative dependence and QOL in elderly patients with malignant tumours , a prospect i ve observational study including 200 patients > 70 years was performed . The primary outcome was postoperative activities of daily living ( ADL < 95 ) , secondary outcome was QOL at 6 months . Multivariate regression was performed to assess the impact of associated factors ( socio-demographic , clinical , functional , cognitive variables , resilience , and EORTC-QLQ-C30 QOL ) . RESULTS Median age of patients was 75 ( 70 - 88 ) years with 69 % males . The majority of operations was for colon carcinoma ; morbidity was 24.8 % , mortality 1.5 % . Impairment in ADL ( < 95 ) affected 6.7 % ( 13/195 ) pre- , and 9.7 % ( 12/124 ) post-operatively . Analyzing factors predicting loss of ADL , the following reached significance : BMI ( OR : 1.7 ; p = 0.019 ) , ADL ( OR : 0.67 ; p = 0.0317 ) , and of the QLQ-C30 : diarrhea ( OR : 1.04 ; p = 0.013 ) , emotional functioning ( OR : 0.91 ; p = 0.0242 ) , physical functioning ( OR : 0.92 ; p = 0.027 ) . QOL paralleled ADL ( pre-op : 65.4 to 67 postoperatively , respectively ) ; predictive were : Karnofsky Index ( Parameter Estimate ( PE ) : 0.55 ; p = 0.0003 ) and ( QLQ-C30 ) emotional functioning ( PE : 0.14 ; p = 0.0208 ) . CONCLUSIONS Those considered for oncologic surgery can be assured that few lose independence . CGA/QOL highlight signs of vulnerability and options for pre-habilitation . Registries including a minimal CGA data set will make pre- selection s reproducible and objectify risk/benefit estimations - relevant for those withheld from potentially curative surgery
All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .