Results : We confirmed the importance of the 4 main factors influencing SC : ( 1 ) environmental factors , ( 2 ) genomic factors , ( 3 ) gene-environment interactions , and ( 4 ) evidence -based interventions .
The model demonstrates the complex network of factors influencing SC .
Background : Smoking behaviour is a major public health problem worldwide .
Several sources have confirmed the implication of genomic factors in smoking behaviour .
These factors interact both with environmental factors and interventions to develop a certain behaviour .
Objectives : Describing the environmental and genomic factors as well as the interventions influencing smoking cessation  ( SC ) and developing a working model incorporating the different factors influencing SC were our main objectives .
Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials.
We analyzed pooled data from two comparable r and omized placebo-controlled clinical trials of bupropion pharmacotherapy for smoking cessation for which data on DRD2 Taq1A genotype were available . A total of 722 smokers across the two trials were r and omized to 10 weeks of sustained-release bupropion hydrochloride or placebo . General estimating equation analysis demonstrated a significant gene x drug interaction ( B = 0.87 , SE = 0.34 , p = .009 ) . Smokers with the A2/A2 genotype using bupropion were more than three times as likely , relative to placebo , to be abstinent at end of treatment ( 35.2 % vs. 15.1 % ; OR = 3.25 , 95 % CI 2.00 - 5.28 ) and at 6 months of follow-up ( 26.7 % vs. 12.2 % ; OR = 2.81 , 95 % CI 1.66 - 4.77 ) , which was attenuated by 12 months ( 16.3 % vs. 10.7 % ; OR = 1.70 , 95 % CI 0.95 - 3.05 ) . We found no significant benefit of bupropion relative to placebo on smoking cessation outcomes at any time point in participants with A1/A1 or A1/A2 genotypes . These data suggest that bupropion may be effective for smoking cessation only in a subgroup of smokers with the DRD2 Taq1 A2/A2 genotype
Results : We confirmed the importance of the 4 main factors influencing SC : ( 1 ) environmental factors , ( 2 ) genomic factors , ( 3 ) gene-environment interactions , and ( 4 ) evidence -based interventions .
The model demonstrates the complex network of factors influencing SC .
Background : Smoking behaviour is a major public health problem worldwide .
Several sources have confirmed the implication of genomic factors in smoking behaviour .
These factors interact both with environmental factors and interventions to develop a certain behaviour .
Objectives : Describing the environmental and genomic factors as well as the interventions influencing smoking cessation  ( SC ) and developing a working model incorporating the different factors influencing SC were our main objectives .