RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .
The Effect Duration of Candesartan Cilexetil Once Daily, in Comparison with Enalapril Once Daily, in Patients with Mild to Moderate Hypertension
Objective : To determine the antihypertensive efficacy , effect duration and safety of the angiotensin II type1 receptor blocker c and esartan cilexetil and the angiotensin converting enzyme inhibitor enalapril once daily in patients with mild to moderate hypertension . Methods : A multicenter , r and omised , double-blind parallel group study was performed in Finl and , France , the Netherl and s , Spain and Sweden . Three-hundred- and -ninety-five men and women in the age range 20 - 80 years with primary hypertension were r and omised to an 8-week double-blind treatment period with either c and esartan cilexetil 8 - 16 mg or enalapril 10 - 20 mg once daily , with forced dose titration after 4 weeks . Non-invasive ambulatory blood pressure was measured for 36 h at baseline and after 8 weeks . The primary efficacy variable was the change in mean diastolic and systolic ambulatory blood pressure 22 - 24 h post-dose . Results : There was a significant difference in the adjusted mean difference for the change from baseline to week 8 between c and esartan cilexetil and enalapril 22 - 24 h post-dose by -3.5 mmHg ( 95 % confidence interval , CI : -6.8 to -0.3 mmHg ; p < 0.032 ) in ambulatory systolic blood pressure and -3.0 mmHg ( 95 % CI : -5.1 to -0.8 mmHg ; p < 0.008 ) in ambulatory diastolic blood pressure . There was a significant difference in adjusted mean daytime ambulatory blood pressure 24 - 36 h post-dose by -4.2 mmHg ( 95 % CI : -6.8 to -1.6 mmHg ; p < 0.002)/-3.5 mmHg ( 95 % CI : -5.1 to -1.8 mmHg ; p < 0.001 ) . Both drugs were generally well tolerated . Conclusion : The results of the present study suggest that advantages may be attributed to the use of c and esartan cilexetil , as compared to enalapril in the treatment of patients with essential hypertension . In comparison with enalapril 20 mg , c and esartan cilexetil 16 mg more effectively lowered blood pressure at trough and in particular on the day following the day after the last dose
RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .