This meta- analysis suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-α
We conducted this systematic review and meta- analysis of prospect i ve studies to determine the effect of  probiotic administration on serum C-reactive protein ( CRP ) concentrations .
Effect of probiotics on pro-inflammatory cytokines and NF-kappaB activation in ulcerative colitis.
AIM To demonstrate the therapeutic effect of probiotics in patients with ulcerative colitis ( UC ) , and their effect on inflammatory mediators and nuclear factor (NF)-kappaB activation in these patients . METHODS Thirty patients with mild to moderate UC were r and omly classified into two groups : sulfasalazine group , who received sulfasalazine 2400 mg/d ; and probiotic group , who received sulfasalazine 2400 mg/d with probiotic . The patients were investigated before and after 8 wk of treatment with probiotic ( Lactobacillus delbruekii and Lactobacillus fermentum ) .  Colonic activity of myeloperoxidase ( MPO ) was assayed with UV spectrophotometry , the colonic content of interleukin (IL)-6 was determined by enzyme-linked immunosorbent assay ( ELISA ) , fecal calprotectin was determined by ELISA , and expression of NF-kappaB p65 and tumor necrosis factor (TNF)-alpha proteins in colonic tissue was identified by immunohistochemistry and reverse transcription polymerase chain reaction , respectively . RESULTS At the start of the study , colonic mucosal injury and inflammation were demonstrated in UC patients by hematoxylin and eosin staining , and an increase in colonic MPO activity , fecal calprotectin , and expression of colonic TNF-alpha and NF-kappaB p65 proteins . The use of probiotic for 8 wk significantly ameliorated the inflammation by decreasing the colonic concentration of IL-6 , expression of TNF-alpha and NF-kappaB p65 , leukocyte recruitment , as demonstrated by a decrease in colonic MPO activity , and the level of fecal calprotectin compared to sulfasalazine group and the control group ( P < 0.05 ) . CONCLUSION Oral supplementation with probiotics could be helpful in maintaining remission and preventing relapse of UC
This meta- analysis suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-α
We conducted this systematic review and meta- analysis of prospect i ve studies to determine the effect of  probiotic administration on serum C-reactive protein ( CRP ) concentrations .