Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Vascular effects of simvastatin combined with ramipril in hypercholesterolemic patients with coronary artery disease, compared with simvastatin alone: a randomized, double-blind, placebo-controlled, crossover study.
Because the mechanisms of the biological effects of statin and angiotensin converting enzyme inhibitor therapies differ , we studied the vascular responses to these therapies in hypercholesterolemic patients with coronary artery disease . We administered simvastatin 20 mg and placebo or ramipril 10 mg daily during 2 months with washout 2 months to 32 hypercholesterolemic patients with coronary artery disease . This study was r and omized , double-blind , placebo-controlled , crossover in design . Simvastatin alone or combined with ramipril significantly changed lipoproteins , and improved the percent flow-mediated dilator response to hyperemia relative to baseline measurements by 33 + /- 6 % and by 50 + /- 14 % , respectively ( both P < 0.001 ) and reduced plasma levels of nitrate relative to baseline measurements ( P=0.413 and 0.037 , respectively ) , the plasma MDA levels relative to baseline measurements by 8 + /- 8 % and by 18 + /- 9 % ( P=0.039 and P < 0.001 , respectively ) and MCP-1 relative to baseline measurements by 7 + /- 4 % and by 13 + /- 3 % , respectively ( P=0.019 and P < 0.001 , respectively ) , and CRP from 0.22 to 0.14 mg/dl and from 0.22 to 0.15 mg/dl , respectively ( P=0.124 and 0.002 , respectively ) , and PAI-1 antigen relative to baseline measurements ( P=0.690 and 0.018 , respectively ) . However , simvastatin combined with ramipril changed to greater but statistically insignificant extent the percent flow-mediated dilator response to hyperemia and plasma levels of nitrate , MDA , MCP-1 , and PAI-1 antigen than simvastatin alone . Simvastatin alone or combined with ramipril showed significant beneficial effects on endothelial function in hypercholesterolemic patients with coronary artery disease . However , simvastatin combined with ramipril did not significantly change , compared with simvastatin alone
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .