Overall , vitamin C did not modify glucose , HbA1c and insulin concentrations .
Meta-regression analyses showed that age was a modifier of the effect of vitamin C on insulin concentration .
Furthermore , the effect size was associated with baseline BMI and plasma glucose levels , and with the duration of the intervention .
In conclusion , greater reduction in glucose concentrations observed in patients with diabetes , older individuals and with more prolonged supplementation .
R and omised controlled trials ( RCTs ) have observed contrasting results on the effects of vitamin C on circulating biomarkers of glycaemic and insulin regulation .
The Effect of Vitamin C Supplementation on Diabetic Hyperlipidaemia: a Double Blind, Crossover Study
Fifty diabetic patients took part in a four‐month , double‐blind crossover study comparing 500 mg of vitamin C daily with placebo . No significant difference was observed between vitamin C and placebo therapy in fasting whole blood glucose , serum cholesterol , triglycerides , and glycosylated haemoglobin levels
Overall , vitamin C did not modify glucose , HbA1c and insulin concentrations .
Meta-regression analyses showed that age was a modifier of the effect of vitamin C on insulin concentration .
Furthermore , the effect size was associated with baseline BMI and plasma glucose levels , and with the duration of the intervention .
In conclusion , greater reduction in glucose concentrations observed in patients with diabetes , older individuals and with more prolonged supplementation .
R and omised controlled trials ( RCTs ) have observed contrasting results on the effects of vitamin C on circulating biomarkers of glycaemic and insulin regulation .