OC could significantly reduce the occurrence of VAP , and consequently , its routine use should be considered for VLBWs to prevent infectious diseases .
OC  significantly reduces the occurrence of VAP and NEC in VLBW infants  .
OC may reduce the incidence of VAP and NEC by increasing IgA levels .
Early OC therapy for mechanical ventilation of low-weight infants may prevent the occurrence of VAP .
OC significantly reduces the occurrence of VAP and NEC in VLBW infants .
OC may reduce the incidence of VAP and NEC by increasing IgA levels .
Early OC therapy for mechanical ventilation of low-weight infants may prevent the occurrence of VAP
Oropharyngeal colostrum ( OC ) is a novel feeding strategy to prevent complications of prematurity .
A meta- analysis was conducted to investigate whether very low birth weight infants ( VLBWs ) can benefit from OC .
Oral colostrum priming shortens hospitalization without changing the immune-microbial milieu
Objective : Oral colostrum priming ( OCP ) after birth in preterm infants is associated with improved weight gain and modification of the oral immunomicrobial environment . We hypothesized that OCP would modify salivary immune peptides and the oral microbiota in preterm infants . Study design : We conducted a prospect i ve , r and omized clinical trial to determine the effects of OCP on salivary immune peptide representation in preterm infants ( < 32 weeks completed gestation at birth ) .  Saliva sample s were collected before and after OCP . Salivary immune peptide representation was determined via mass spectroscopy . Oral microbiota representation was determined via sequencing of the 16S rRNA gene . Results : Neonates who received OCP ( n=48 ) had a 16-day reduction in the median length of hospitalization as compared with infants who did not receive OCP ( n=51 ) . No differences in salivary immune peptide sequence representation before OCP between groups were found . Longitudinal changes in peptides were detected ( lysozyme C , immunoglobulin A , lactoferrin ) but were limited to a single peptide difference ( α-defensin 1 ) between primed and unprimed infants after OCP . We found no difference in microbial diversity between treatment groups at any time point , but diversity decreased significantly over time in both groups . OCP treatment marginally modified oral taxa with a decline in abundance of Streptococci in the OCP group at 30 days of life . Conclusions : OCP had neither an effect on the salivary peptides we examined nor on overall oral bacterial diversity and composition . Infants who received OCP had a reduced length of hospitalization and warrants further investigation
OC could significantly reduce the occurrence of VAP , and consequently , its routine use should be considered for VLBWs to prevent infectious diseases .
OC  significantly reduces the occurrence of VAP and NEC in VLBW infants  .
OC may reduce the incidence of VAP and NEC by increasing IgA levels .
Early OC therapy for mechanical ventilation of low-weight infants may prevent the occurrence of VAP .
OC significantly reduces the occurrence of VAP and NEC in VLBW infants .
OC may reduce the incidence of VAP and NEC by increasing IgA levels .
Early OC therapy for mechanical ventilation of low-weight infants may prevent the occurrence of VAP
Oropharyngeal colostrum ( OC ) is a novel feeding strategy to prevent complications of prematurity .
A meta- analysis was conducted to investigate whether very low birth weight infants ( VLBWs ) can benefit from OC .