Conclusions The current evidence does not suggest an association between leptin and PCa outcome .
However , there may be an inverse association between adiponectin and the incidence of advanced PCa that should be investigated by further studies .
Background Obesity has been proposed as a risk factor for prostate cancer ( PCa ) .
In obesity , serum levels of the appetite-regulating hormones — leptin , adiponectin , and ghrelin — become deregulated .
Objective To explore whether serum levels of appetite-regulating hormones associate with the incidence of PCa , the incidence of advanced disease , or PCa-specific mortality .
Association between prediagnostic biomarkers of inflammation and endothelial function and cancer risk: a nested case-control study.
Experimental and prevalent case-control studies suggest an association between biomarkers of inflammation , endothelial function , and adiposity and cancer risk , but results from prospect i ve studies have been limited . The authors ' objective was to prospect ively examine the relations between these biomarkers and cancer risk . A nested case-control study was design ed within the Supplémentation en Vitamines et Minéraux Antioxydants ( SU.VI.MAX ) Study , a nationwide French cohort study , to include all first primary incident cancers diagnosed between 1994 and 2007 ( n = 512 ) . Cases were matched with r and omly selected controls ( n = 1,024 ) on sex , age ( in 2-year strata ) , body mass index ( weight (kg)/height (m)(2 ) ; < 25 vs. ≥25 ) , and SU.VI.MAX intervention group . Conditional logistic regression was used to study the associations between prediagnostic levels of high-sensitivity C-reactive protein ( hs-CRP ) , adiponectin , leptin , soluble intercellular adhesion molecule 1 ( sICAM-1 ) , soluble vascular cell adhesion molecule 1 , soluble E-selectin , and monocyte chemoattractant protein 1 and cancer risk . All statistical tests were 2-sided . Plasma sICAM-1 level was positively associated with breast cancer risk ( for quartile 4 vs. quartile 1 , multivariate odds ratio ( OR ) = 1.86 , 95 % confidence interval ( CI ) : 1.06 , 3.26 ; P(trend ) = 0.048 ) . Plasma hs-CRP level was positively associated with prostate cancer risk ( for quartile 4 vs. quartile 1 , multivariate OR = 3.04 , 95 % CI : 1.28 , 7.23 ; P(trend ) = 0.03 ) . These results suggest that prediagnostic hs-CRP and sICAM-1 levels are associated with increased prostate and breast cancer risk , respectively
Conclusions The current evidence does not suggest an association between leptin and PCa outcome .
However , there may be an inverse association between adiponectin and the incidence of advanced PCa that should be investigated by further studies .
Background Obesity has been proposed as a risk factor for prostate cancer ( PCa ) .
In obesity , serum levels of the appetite-regulating hormones — leptin , adiponectin , and ghrelin — become deregulated .
Objective To explore whether serum levels of appetite-regulating hormones associate with the incidence of PCa , the incidence of advanced disease , or PCa-specific mortality .