Enduring changes in personality/attitudes , depression , spirituality , anxiety , wellbeing , substance misuse , meditative practice s , and mindfulness were documented .
Mystical experiences , connectedness , emotional breakthrough , and increased neural entropy were related to these long-term changes in psychological functioning .
Finally , with proper screening , preparation , supervision , and integration , limited aversive side effects were noted by study participants .
Research into the basic effects and therapeutic applications of  psychedelic drugs  has grown considerably in recent years .
Yet , pressing questions remain regarding the substances ' lasting effects .
Although individual studies have begun monitoring sustained changes , no study to- date has synthesized this information .
Long-term follow-up of psilocybin-facilitated smoking cessation
ABSTRACT Background : A recent open-label pilot study ( N = 15 ) found that two to three moderate to high doses ( 20 and 30 mg/70 kg ) of the serotonin 2A receptor agonist , psilocybin , in combination with cognitive behavioral therapy ( CBT ) for smoking cessation , result ed in substantially higher 6-month smoking abstinence rates than are typically observed with other medications or CBT alone . Objectives : To assess long-term effects of a psilocybin-facilitated  smoking cessation program at ≥12 months after psilocybin administration . Methods : The present report describes biologically verified smoking abstinence outcomes of the previous pilot study at ≥12 months , and related data on subjective effects of psilocybin . Results : All 15 participants completed a 12-month follow-up , and 12 ( 80 % ) returned for a long-term ( ≥16 months ) follow-up , with a mean interval of 30 months ( range = 16–57 months ) between target-quit date ( i.e. , first psilocybin session ) and long-term follow-up . At 12-month follow-up , 10 participants ( 67 % ) were confirmed as smoking abstinent . At long-term follow-up , nine participants ( 60 % ) were confirmed as smoking abstinent . At 12-month follow-up 13 participants ( 86.7 % ) rated their psilocybin experiences among the five most personally meaningful and spiritually significant experiences of their lives . Conclusion : These results suggest that in the context of a structured treatment program , psilocybin holds considerable promise in promoting long-term smoking abstinence . The present study adds to recent and historical evidence suggesting high success rates when using classic psychedelics in the treatment of addiction . Further research investigating psilocybin-facilitated treatment of substance use disorders is warranted
Enduring changes in personality/attitudes , depression , spirituality , anxiety , wellbeing , substance misuse , meditative practice s , and mindfulness were documented .
Mystical experiences , connectedness , emotional breakthrough , and increased neural entropy were related to these long-term changes in psychological functioning .
Finally , with proper screening , preparation , supervision , and integration , limited aversive side effects were noted by study participants .
Research into the basic effects and therapeutic applications of  psychedelic drugs  has grown considerably in recent years .
Yet , pressing questions remain regarding the substances ' lasting effects .
Although individual studies have begun monitoring sustained changes , no study to- date has synthesized this information .