Findings related to effectiveness ( treatment discontinuation , quality of life , and neurocognitive improvements ) were generally consistent with those observed in non-Chinese population s. No new safety signals specific for Chinese population s were raised for olanzapine .
Chinese and non-Chinese population s with schizophrenia or bipolar disorder treated with olanzapine display broadly similar responses .
BACKGROUND Despite the burden of schizophrenia and bipolar disorder in the Chinese population , country-specific data to guide practitioners regarding antipsychotic therapy are lacking .
Long-term (3-year) neurocognitive effectiveness of antipsychotic medications in first-episode non-affective psychosis: a randomized comparison of haloperidol, olanzapine, and risperidone
Introduction The initially postulated superior neurocognitive effectiveness of second-generation antipsychotics is currently under debate . Methods A prospect i ve , r and omized , open-label study was carried out to compare the long-term neurocognitive effectiveness of haloperidol , olanzapine , and risperidone in the first episode of schizophrenia spectrum disorders . A final sample of 79 patients r and omized to haloperidol ( N = 28 ) , olanzapine ( N = 23 ) , or risperidone ( N = 28 ) who completed clinical and cognitive evaluations at baseline and 3-year follow-up was included in the final analysis . Forty-one healthy individuals were also included in the final analysis . The main outcome measure was cognitive changes at 3-year follow-up . Due to the fact that some of the patients had switched their initially prescribed antipsychotic medication during the course of the study ( 6 out of 28 in haloperidol group , 18 out of 23 in olanzapine group , and 24 out of 28 in risperidone group continued with the initial study drug at 3-year assessment ) , we have also conducted a per protocol analysis . Results Overall , cognitive changes were similar in the three treatment groups and controls , although a greater improvement in Rey Auditory Verbal Learning Test , Digit Symbol , and Iowa Gambling Test was found in the treatment groups . The better performance observed on Rey Auditory Verbal Learning Test and Digit Symbol in olanzapine treatment group was likely explained by the lower prevalence of use of antimuscarinic drugs . These results were essentially similar to those found in the intention-to-treat analysis . Conclusions The major conclusion of this study is that haloperidol , olanzapine , and risperidone have not demonstrated substantial neurocognitive effectiveness , improving cognitive deficits present in the early phases of the illness . The study also underscores the importance of exploring new drugs for the treatment of cognitive impairments and associated functional disabilities in schizophrenia
Findings related to effectiveness ( treatment discontinuation , quality of life , and neurocognitive improvements ) were generally consistent with those observed in non-Chinese population s. No new safety signals specific for Chinese population s were raised for olanzapine .
Chinese and non-Chinese population s with schizophrenia or bipolar disorder treated with olanzapine display broadly similar responses .
BACKGROUND Despite the burden of schizophrenia and bipolar disorder in the Chinese population , country-specific data to guide practitioners regarding antipsychotic therapy are lacking .