There is low to high ( majority moderate ) certainty for small improvements of unclear clinical importance in plasma glucose , triglycerides , and HDL concentrations favoring low-carbohydrate food at half of the prespecified time points .
There was little to no difference in LDL concentration or any of the secondary outcomes ( body weight , waist circumference , blood pressure , quality of life ) in response to either of the diets ( very-low- to high-certainty evidence ) .
Conclusions Currently available data provide low- to moderate-certainty evidence that dietary carbohydrate restriction to a maximum of 40 % yields slightly better metabolic control of uncertain clinical importance than reduction in fat to a maximum of 30 % in people with T2D .
Background It remains uncertain which diet is best for people with type 2 diabetes ( T2D ) .
Objective We compared the effects of dietary carbohydrate restriction with fat restriction on markers of metabolic syndrome and quality of life in people with T2D .
Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus
Brackground : The safety and tolerability of very low-calorie-ketogenic ( VLCK ) diets are a current concern in the treatment of obese type 2 diabetes mellitus ( T2DM ) patients . Objective : Evaluating the short-term safety and tolerability of a VLCK diet ( < 50 g of carbohydrate daily ) in an interventional weight loss program including lifestyle and behavioral modification support ( Diaprokal Method ) in subjects with T2DM . Methods : Eighty-nine men and women , aged between 30 and 65 years , with T2DM and body mass index between 30 and 35 kg m−2 participated in this prospect i ve , open-label , multi-centric r and omized clinical trial with a duration of 4 months . Forty-five subjects were r and omly assigned to the interventional weight loss ( VLCK diet ) , and 44 to the st and ard low-calorie diet . Results : No significant differences in the laboratory safety parameters were found between the two study groups . Changes in the urine albumin-to-creatinine ratio in VLCK diet were not significant and were comparable to control group . Creatinine and blood urea nitrogen did not change significantly relative to baseline nor between groups . Weight loss and reduction in waist circumference in the VLCK diet group were significantly larger than in control subjects ( both P<0.001 ) . The decline in HbA1c and glycemic control was larger in the VLCK diet group ( P<0.05 ) . No serious adverse events were reported and mild AE in the VLCK diet group declined at last follow-up . Conclusions : The interventional weight loss program based on a VLCK diet is most effective in reducing body weight and improvement of glycemic control than a st and ard hypocaloric diet with safety and good tolerance for T2DM patients
There is low to high ( majority moderate ) certainty for small improvements of unclear clinical importance in plasma glucose , triglycerides , and HDL concentrations favoring low-carbohydrate food at half of the prespecified time points .
There was little to no difference in LDL concentration or any of the secondary outcomes ( body weight , waist circumference , blood pressure , quality of life ) in response to either of the diets ( very-low- to high-certainty evidence ) .
Conclusions Currently available data provide low- to moderate-certainty evidence that dietary carbohydrate restriction to a maximum of 40 % yields slightly better metabolic control of uncertain clinical importance than reduction in fat to a maximum of 30 % in people with T2D .
Background It remains uncertain which diet is best for people with type 2 diabetes ( T2D ) .
Objective We compared the effects of dietary carbohydrate restriction with fat restriction on markers of metabolic syndrome and quality of life in people with T2D .