Garlic reduces TC to a modest extent , an effect driven mostly by the modest reductions in TAG , without appreciable LDL lowering or HDL elevation .
Higher baseline line TC levels and the use of dietary modification may alter the effect of garlic on these parameters .
In order to determine the impact of  garlic on total cholesterol ( TC ) , TAG levels , as well as LDL and HDL  , and establish if any variables have an impact on the magnitude of this effect , a meta- analysis was conducted .
Garlic extract therapy in children with hypercholesterolemia.
OBJECTIVE To determine whether garlic extract therapy is efficacious and safe in children with hypercholesterolemia . DESIGN R and omized , double-blind , placebo-controlled clinical trial . SETTING Specialized pediatric lipid disorders ambulatory clinic . PARTICIPANTS Thirty pediatric patients , aged 8 to 18 years , who had familial hyperlipidemia and a minimum fasting total cholesterol level greater than 4.8 mmol/L ( > 185 mg/dL ) . INTERVENTION An 8-week course of a commercially available garlic extract ( Kwai [ Lichtwer Pharma , Berlin , Germany ] , 300 mg , 3 times a day ) or an identical placebo . MAIN OUTCOME MEASURES Absolute and relative changes in fasting lipid profile parameters . RESULTS The groups were equivalent at baseline and compliance was similar in the 2 groups ( P = .45 ) . There was no significant relative attributable effect of garlic extract on fasting total cholesterol ( + 0.6 % [ 95 % confidence interval , -5.8 % to + 6.9%1 ) or low-density lipoprotein cholesterol ( -0.5 % [ 95 % confidence interval , -8.7 % to + 7.6 % ] ) . The lower limits of the confidence intervals did not include -10 % , the minimum relative attributable effect believed to be clinical ly important . Likewise , no significant effect was seen on the levels of high-density lipoprotein , triglycerides , apolipoprotein B-100 , lipoprotein ( a ) , fibrinogen , homocysteine , or blood pressure . There was a small effect on apolipoprotein A-I ( + 10.0 % [ 95 % confidence interval , + 1.2 % to + 16.5 % ] P=.03 ) . There were no differences in adverse effects between groups . CONCLUSION Garlic extract therapy has no significant effect on cardiovascular risk factors in pediatric patients with familial hyperlipidemia
Garlic reduces TC to a modest extent , an effect driven mostly by the modest reductions in TAG , without appreciable LDL lowering or HDL elevation .
Higher baseline line TC levels and the use of dietary modification may alter the effect of garlic on these parameters .
In order to determine the impact of  garlic on total cholesterol ( TC ) , TAG levels , as well as LDL and HDL  , and establish if any variables have an impact on the magnitude of this effect , a meta- analysis was conducted .