Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention .
The data are insufficient to recommend the use of statins before EC .
Finally , perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF
The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation ( AF ) , inflammation and oxidative stress , with emphasis on the potential of statins to decrease the incidence of different types of AF , including new-onset AF , after electrical cardioversion ( EC ) and after cardiac surgery .
Observational and clinical trials have studied the impact of statin therapy on new-onset , post-EC or postoperative AF .
Efficacy of nonsteroidal anti-inflammatory medications for prevention of atrial fibrillation following coronary artery bypass graft surgery.
This study was design ed to test whether nonsteroidal anti-inflammatory medications could reduce the frequency of atrial fibrillation  after coronary artery bypass graft surgery . The study was design ed as an open-label , r and omized trial . Patients undergoing first-time coronary artery bypass graft surgery were considered eligible . Patients with a history of atrial fibrillation , serum creatinine > 2.0 mg/dL , on antiarrhythmic treatment , and those undergoing concomitant valvular surgery were excluded . The study was conducted in a single , university-affiliated community hospital . The research ers ' role in the study was restricted to r and omizing the patients and collecting data . The primary clinical care team made all decisions regarding patient care . One hundred patients were r and omized to two groups : one received 30 mg ketorolac intravenously every 6 hours until able to take oral medications , at which point the patients were switched to 600 mg ibuprofen orally three times a day ; the other group received conventional treatment . The primary end point of the study was incidence of atrial fibrillation in the immediate postoperative period . Atrial fibrillation occurred in 14 patients ( 28.6 % ) in the conventional treatment group vs. five patients ( 9.8 % ) in the ibuprofen group ( p<0.017 ) . Nonsteroidal anti-inflammatory medications were relatively safe and effective in significantly reducing the incidence of atrial fibrillation after coronary artery bypass graft surgery
Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention .
The data are insufficient to recommend the use of statins before EC .
Finally , perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF
The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation ( AF ) , inflammation and oxidative stress , with emphasis on the potential of statins to decrease the incidence of different types of AF , including new-onset AF , after electrical cardioversion ( EC ) and after cardiac surgery .
Observational and clinical trials have studied the impact of statin therapy on new-onset , post-EC or postoperative AF .