Results show that various classes of antidepressants exert improving effects on cognitive function across several cognitive domains .
Specifically , studies suggest that SSRIs , the SSRE tianeptine , the SNRI duloxetine , vortioxetine and other antidepressants such as bupropion and moclobemide may exert certain improving effects on cognitive function in depression , such as in learning and memory and executive function .
The few non-pharmacological studies conducted employing cognitive orientated treatments and cognitive remediation therapy show promising results for the improvement of cognitive impairment in depression .
Cognitive dysfunction is of clinical significance and exerts longst and ing implication on patients ׳ function .
Pharmacological and non-pharmacological treatments of cognitive dysfunction are emerging .
This review evaluates pharmacological and non-pharmacological treatments of cognitive impairment primarily in the domains of memory , attention , processing speed and executive function in clinical depression .
Does antidepressant therapy improve cognition in elderly depressed patients?
OBJECTIVES To analyze the effects of antidepressants on cognitive functioning in elderly depression . METHODS Data were pooled for elderly participants with major depression from two double-blind 12-week studies ( n = 444 ) comparing sertraline to fluoxetine and to nortriptyline . A cognitive battery was performed pre-treatment and post-treatment that included the Shopping List Task ( SLT ) , which quantifies short-term and long-term memory storage and retrieval , and the Digit Symbol Substitution Test ( DSST ) , which measures visual tracking , motor performance , and coding . RESULTS Older age , male gender , higher systolic blood pressure , and higher illness severity were associated with lower performance on specific cognitive measures at baseline . For the entire group , improved depression and a lower anticholinergic side effect ( dry mouth and constipation ) severity were associated with statistically significant improvement in the SLT and DSST . The correlations between improvements in depression and improvement in tested cognitive function were highest for sertraline followed by nortriptyline and then fluoxetine . CONCLUSIONS Acute improvement in depression is associated with cognitive improvement as measured by the SLT and DSST . Prospect i ve studies are warranted to study the effects of potential differences among antidepressant therapies on long-term cognitive outcomes in geriatric depression
Results show that various classes of antidepressants exert improving effects on cognitive function across several cognitive domains .
Specifically , studies suggest that SSRIs , the SSRE tianeptine , the SNRI duloxetine , vortioxetine and other antidepressants such as bupropion and moclobemide may exert certain improving effects on cognitive function in depression , such as in learning and memory and executive function .
The few non-pharmacological studies conducted employing cognitive orientated treatments and cognitive remediation therapy show promising results for the improvement of cognitive impairment in depression .
Cognitive dysfunction is of clinical significance and exerts longst and ing implication on patients ׳ function .
Pharmacological and non-pharmacological treatments of cognitive dysfunction are emerging .
This review evaluates pharmacological and non-pharmacological treatments of cognitive impairment primarily in the domains of memory , attention , processing speed and executive function in clinical depression .