Findings were mixed and showed various effects of cannabinoid administration on several aspects of sleep .
This paper review s the literature regarding the effects of cannabinoid administration on  sleep in humans .
Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomised, double-blind crossover trial
Background Many patients with amyotrophic lateral sclerosis ( ALS ) experience cramps during the course of the disease but so far , none of the medications used has been of proven benefit . The objective was to determine the effect of orally administered tetrahydrocannabinol ( THC ) on cramps in ALS patients . Methods The authors conducted a r and omised , double-blind , placebo-controlled crossover trial in 27 ALS patients suffering from moderate to severe ( visual analogue scale ( VAS ) ; VAS≥4 ) daily cramps . There were 7 women and 20 men with a mean age of 57 years and a mean functional ALS score ( ALSFRS-R ) of 38.4 . Patients were r and omly assigned to receive 5 mg THC twice daily followed by placebo or vice versa . Each treatment period lasted for 2 weeks and was preceded by a 2-week drug-free observation period ( run-in , wash-out period respectively ) . The primary outcome measure was change in cramp intensity as assessed by a VAS . Secondary outcome measures included the number of cramps per day , number of cramps during daytime and bedtime , intensity of fasciculations ( VAS ) as well as vali date d measures of quality of life ( ALSAQ-40 ) , quality of sleep ( SDQ ) , appetite ( FAACT ) and depression ( HADS ) . Results Complete data were available from 22 patients . THC was well tolerated . There was no evidence for a treatment effect on cramp intensity , number of cramps , fasciculation intensity or any of the other secondary outcome measures . Conclusions This interventional study with orally administered THC 5 mg twice daily did not demonstrate subjective improvement of cramp intensity in ALS patients
Findings were mixed and showed various effects of cannabinoid administration on several aspects of sleep .
This paper review s the literature regarding the effects of cannabinoid administration on  sleep in humans .