As for physical exercise modalities , aerobic exercise , but not other modalities , increased adiponectin and reduced leptin levels .
In conclusion , physical exercise and , specifically , aerobic exercise , leads to higher adiponectin and lower leptin levels  in prediabetic and diabetic adults .
It is speculated that lifestyle interventions known to improve diabetic metabolic state may exert their effects via adipokines .
The aim of this systematic review and meta- analysis was to evaluate the chronic effects of physical exercise on adiponectin and leptin levels in adult prediabetic and diabetic individuals .
Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men.
OBJECTIVE We investigated the effect of an intensive training program on fasting leptin and adiponectin levels . METHODS Sixteen middle-aged men with type 2 diabetes were r and omly assigned to either a training or control group . The training program consisted of 8 weeks of supervised endurance exercise ( 75 % VO(2peak ) , 45 min ) twice a week , with intermittent exercise ( five 2 min exercises at 85 % VO(2peak ) separated by 3 min exercises at 50 % VO(2peak ) ) once a week , on an ergocycle . RESULTS Training decreased abdominal fat by 44 % , increased mid-thigh muscle cross-sectional area by 24 % , and improved insulin sensitivity by 58 % without significant change in body weight . Compared with controls , no significant variation in leptin or adiponectin levels was observed . However , in the trained group , change in adiponectin correlated with change in body weight ( Spearman rank correlation , r(s):-0.76 , P=0.03 ) but not with insulin sensitivity or abdominal adiposity variations . CONCLUSIONS An 8 week intensive training program inducing a marked reduction in abdominal fat and increase in insulin sensitivity does not affect adiponectin and leptin levels in men with type 2 diabetes
As for physical exercise modalities , aerobic exercise , but not other modalities , increased adiponectin and reduced leptin levels .
In conclusion , physical exercise and , specifically , aerobic exercise , leads to higher adiponectin and lower leptin levels  in prediabetic and diabetic adults .
It is speculated that lifestyle interventions known to improve diabetic metabolic state may exert their effects via adipokines .
The aim of this systematic review and meta- analysis was to evaluate the chronic effects of physical exercise on adiponectin and leptin levels in adult prediabetic and diabetic individuals .