The meta- analysis showed a significant increase in plasma adiponectin levels following statin therapy .
Although statins are known to increase the risk for new onset diabetes mellitus , our data might suggest that the mechanism for this is unlikely to be due to a reduction in adiponectin expression
BACKGROUND AND AIMS The effect of statin therapy on plasma adiponectin levels has not been conclusively studied .
Therefore , we aim ed to evaluate this effect through a systematic review and meta- analysis of available r and omized controlled trials ( RCTs ) .
Additive Beneficial Effects of Losartan Combined With Simvastatin in the Treatment of Hypercholesterolemic, Hypertensive Patients
Background —Biological mechanisms underlying statin and angiotensin II type 1 receptor blocker therapies differ . Therefore , we compared vascular and metabolic responses to these therapies either alone or in combination in hypercholesterolemic , hypertensive patients . Methods and Results —This was a r and omized , double-blind , placebo-controlled crossover trial with 3 treatment arms ( each 2 months ) and 2 washout periods ( each 2 months ) . Forty-seven hypertensive , hypercholesterolemic patients were given simvastatin 20 mg and placebo , simvastatin 20 mg and losartan 100 mg , or losartan 100 mg and placebo daily during each 2-month treatment period . Losartan alone or combined therapy significantly reduced blood pressure compared with simvastatin alone . Compared with losartan alone , simvastatin alone or combined therapy significantly changed lipoproteins . All 3 treatment arms significantly improved flow-mediated dilator response to hyperemia and decreased plasma malondialdehyde and monocyte chemoattractant protein-1 levels relative to baseline measurements . However , these parameters were changed to a greater extent with combined therapy compared with simvastatin or losartan alone ( both P<0.001 and P=0.030 for monocyte chemoattractant protein-1 by ANOVA ) . Combined therapy or losartan alone significantly increased plasma adiponectin levels and insulin sensitivity ( determined by QUICKI ) relative to baseline measurements . These changes were significantly greater than in the group treated with simvastatin alone ( P<0.001 for adiponectin , P=0.029 for QUICKI by ANOVA ) . Conclusions —Simvastatin combined with losartan improves endothelial function and reduces inflammatory markers to a greater extent than monotherapy with either drug in hypercholesterolemic , hypertensive patients
The meta- analysis showed a significant increase in plasma adiponectin levels following statin therapy .
Although statins are known to increase the risk for new onset diabetes mellitus , our data might suggest that the mechanism for this is unlikely to be due to a reduction in adiponectin expression
BACKGROUND AND AIMS The effect of statin therapy on plasma adiponectin levels has not been conclusively studied .
Therefore , we aim ed to evaluate this effect through a systematic review and meta- analysis of available r and omized controlled trials ( RCTs ) .