Conclusion This study suggests that the probiotics supplementation could potentially reduce the weight gain and improve some of the associated metabolic parameters , which may become an effective strategy for the prevention and treatment of obesity in adult individuals
Background The prevalence of overweight/obesity in adults is raised to 39 % , which is nearly tripled more than 1975 .
The alteration of the gut microbiome has been widely accepted as one of the main causal factors .
To find an effective strategy for the prevention and treatment of overweight/obesity , a systematic review and meta- analysis were design ed .
Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals.
Our previous study showed that supplementation with a combination of Lactobacillus curvatus ( L. curvatus ) HY7601 and Lactobacillus plantarum ( L. plantarum ) KY1032 reduced the body weight , body fat percentage , body fat mass and L1 subcutaneous fat area in overweight subjects . We aim ed to evaluate whether the changes in adiposity after supplementation with Lactobacillus strains were associated with metabolic intermediates . A r and omized , double-blind , placebo-controlled study was conducted on 66 non-diabetic and overweight individuals . Over a 12-week period , the probiotic group consumed 2 g of probiotic powder , whereas the placebo group consumed the same product without the probiotics . To investigate metabolic alterations , we performed plasma metabolomics using ultra-performance liquid chromatography and mass spectrometry ( UPLC-LTQ/Orbitrap MS ) . Probiotic supplementation significantly increased the levels of octenoylcarnitine ( C8:1 ) , tetradecenoylcarnitine ( C14:1 ) , decanoylcarnitine ( C10 ) and dodecenoylcarnitine ( C12:1 ) compared with the levels from placebo supplementation . In the probiotic group , the changes in the body weight , body fat percentage , body fat mass and L1 subcutaneous fat area were negatively associated with changes in the levels of C8:1 , C14:1 , C10 and C12:1 acylcarnitines . In overweight individuals , probiotic-induced weight loss and adiposity reduction from the probiotic supplementation were associated with an increase in medium-chain acylcarnitines
Conclusion This study suggests that the probiotics supplementation could potentially reduce the weight gain and improve some of the associated metabolic parameters , which may become an effective strategy for the prevention and treatment of obesity in adult individuals
Background The prevalence of overweight/obesity in adults is raised to 39 % , which is nearly tripled more than 1975 .
The alteration of the gut microbiome has been widely accepted as one of the main causal factors .
To find an effective strategy for the prevention and treatment of overweight/obesity , a systematic review and meta- analysis were design ed .