We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
Growth, Tolerance and Biochemical Measures in Healthy Infants Fed a Partially Hydrolyzed Rice Protein-Based Formula: A Randomized, Blinded, Prospective Trial
Objective : To evaluate growth , tolerance and plasma biochemistries in infants fed an experimental rice protein-based infant formula .  Design : R and omized , blinded , 16 week parallel feeding trial of 65 healthy infants fed either an experimental partially hydrolyzed rice protein-based infant formula fortified with lysine and threonine ( RPF , n = 32 ) , or a st and ard intact cow ’s milk protein-based formula ( CMF , n = 33 ) as a control . Assessment s occurred at enrollment ( average 2 days ) , 2 , 4 , 8 , and 16 weeks of age . Results : Growth as indicated by weight , length , and head circumference was not different between the 2 formula groups . All plasma biochemistries for both groups were within reference normal range . However , RPF group had lower phosphorus and urea nitrogen , lower essential amino acids except threonine , which was higher , and lower ratio of essential ( including semi-essential ) to non-essential amino acids . Differences in the concentrations and ratios of amino acids became less as feeding progressed with age . Plasma total protein , albumin , prealbumin , calcium , magnesium , and alkaline phosphatase were not different between groups . Conclusion : Healthy infants fed an experimental partially hydrolyzed rice protein-based formula  had normal growth , tolerance , and plasma biochemistry comparable to those of infants fed a st and ard intact milk protein-based formula , despite some differences in amino acid profiles
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .