The present systematic review shows that , with the exception of laparoscopic surgery , objective evidence of the effect of individual components of ERAS protocol s in reducing the stress response following colorectal surgery is limited
Abstract Enhanced Recovery or Fast Track Recovery after Surgery protocol s ( ERAS ) have significantly changed perioperative care following colorectal surgery and are promoted as reducing the stress response to surgery .
Antioxidant-enriched enteral nutrition and immuno-inflammatory response after major gastrointestinal tract surgery.
Major surgery induces an immuno-inflammatory response accompanied by oxidative stress that may impair cellular function and delay recovery . The objective of the study was to investigate the effect of an enteral supplement , containing glutamine and antioxidants , on circulating levels of immuno-inflammatory markers after major gastrointestinal tract surgery . Patients ( n 21 ) undergoing major gastrointestinal tract surgery were r and omised in a single-centre , open-label study . The effects on circulating levels of immuno-inflammatory markers were determined on the day before surgery and on days 1 , 3 , 5 and 7 after surgery . Major gastrointestinal surgery increased IL-6 , TNF receptor 55/60 ( TNF-R55 ) and C-reactive protein ( CRP ) . Surgery reduced human leucocyte antigen-DR ( HLA-DR ) expression on monocytes . CRP decrease was more pronounced in the first 7 d in the treatment group compared with the control group . In the treatment group , from the moment Module AOX was administered on day 1 after surgery , TNF receptor 75/80 ( TNF-R75 ) level decreased until the third post-operative day and then stabilised , whereas in the control group the TNF-R75 level continued to increase . The results of the present pilot study suggest that enteral nutrition enriched with glutamine and antioxidants possibly moderates the immuno-inflammatory response ( CRP , TNF-R75 ) after surgery
The present systematic review shows that , with the exception of laparoscopic surgery , objective evidence of the effect of individual components of ERAS protocol s in reducing the stress response following colorectal surgery is limited
Abstract Enhanced Recovery or Fast Track Recovery after Surgery protocol s ( ERAS ) have significantly changed perioperative care following colorectal surgery and are promoted as reducing the stress response to surgery .