Our data suggested that N.S supplementation had significant impacts on liver and kidney parameters leading to a decrease in ALP and BUN levels .
The aim of this systematic review and dose-response meta- analysis was to determine the effect of Nigella Sativa ( N.S ) supplementation on  liver and kidney parameters .
Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double-blind, placebo-controlled, clinical trial.
Pre clinical studies have shown beneficial effects of black seed ( Nigella sativa L. ) in the prevention and treatment of renal stones .  Hence , we design ed a study to evaluate the renal-stone-dissolving efficacy of black seed .  Sixty patients with renal stones were r and omly enrolled in two arms of a r and omized , triple-blind , placebo-controlled , clinical trial . The patients were treated by black seed capsules ( 500 mg ) or placebo two times per day for 10 weeks . Patients were assessed in terms of size of renal stones by using sonography before and after intervention . In the black seed group , 44.4 % of patients excreted their stones completely , and the size of the stones remained unchanged and decreased in 3.7 % and 51.8 % of patients , respectively . In contrast , in the placebo group , 15.3 % of the patients excreted their stones completely , 11.5 % had reduction in stone size , 15.3 % had increase in stone size , and 57.6 % had no change in their stone size . The difference in the mean size of renal stones after the study was significant between the two groups ( p < 0.05 ) . N. sativa L. , as compared with placebo , is demonstrated to have significant positive effects on disappearance or reduction of size of kidney stones
Our data suggested that N.S supplementation had significant impacts on liver and kidney parameters leading to a decrease in ALP and BUN levels .
The aim of this systematic review and dose-response meta- analysis was to determine the effect of Nigella Sativa ( N.S ) supplementation on  liver and kidney parameters .