This meta- analysis concludes that l-arginine supplementation can significantly reduce blood TAG levels ; however , there is insufficient evidence to support its hypocholesterolaemic effects .
A number of clinical trials have examined the effect of l-arginine on lipid profile in recent years ; however , the results remain equivocal .
Therefore , the present study aims to summarise and quantitatively examine the available evidence on the effectiveness l-arginine supplementation on lipid parameters using a systematic review and meta-analytic approach .
Dyslipidemia and Hyperglycemia Predict Coronary Heart Disease Events in Middle-Aged Patients With NIDDM
Patients with NIDDM are at increased risk for coronary heart disease ( CHD ) . However , information on the predictive value of cardiovascular risk factors and the degree of hyperglycemia with respect to the risk for CHD in diabetic patients is still limited . Therefore , we carried out a prospect i ve study on risk factors for CHD , including a large number of NIDDM patients . At baseline , risk factor levels of CHD were determined in 1,059 NIDDM patients ( 581 men and 478 women ) , aged from 45 to 64 years . These patients were followed up to 7 years with respect to CHD events . Altogether , 158 NIDDM patients ( 97 men [ 16.7 % ] and 61 women [ 12.8 % ] ) died of CHD and 256 NIDDM patients ( 156 men [ 26.8 % ] and 100 women [ 20.9 % ] ) had a serious CHD event ( death from CHD or nonfatal myocardial infa rct ion ) . A previous history of myocardial infa rct ion , low HDL cholesterol level ( < 1.0 mmol/l ) , high non-HDL cholesterol ( > 5.2 mmol/l ) , high total triglyceride level ( > 2.3 mmol/l ) , and high fasting plasma glucose ( > 13.4 mmol/l ) were associated with a twofold increase in the risk of CHD mortality or morbidity , independently of other cardiovascular risk factors . High calculated LDL cholesterol level ( ≥4.1 mmol/l ) was significantly associated with all CHD events . The simultaneous presence of high fasting glucose ( > 13.4 mmol/l ) with low HDL cholesterol , low HDL – to – total cholesterol ratio , or high total triglycerides further increased the risk for CHD events up to threefold . Our 7-year follow-up study provides evidence that dyslipidemia and poor glycemic control predict CHD mortality and morbidity in patients with NIDDM
This meta- analysis concludes that l-arginine supplementation can significantly reduce blood TAG levels ; however , there is insufficient evidence to support its hypocholesterolaemic effects .
A number of clinical trials have examined the effect of l-arginine on lipid profile in recent years ; however , the results remain equivocal .
Therefore , the present study aims to summarise and quantitatively examine the available evidence on the effectiveness l-arginine supplementation on lipid parameters using a systematic review and meta-analytic approach .