In both rodent and cell culture models , CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus .
In rodent models , CBD was found to attenuate alcohol-induced hepatotoxicity , specifically , alcohol-induced steatosis .
Finally , findings from pre clinical rodent models also indicate that CBD attenuates cue-elicited and stress-elicited alcohol seeking , alcohol self-administration , withdrawal-induced convulsions , and impulsive discounting of delayed rewards .
In human studies , CBD was well tolerated and did not interact with the subjective effects of alcohol .
Collectively , given its favorable effects on alcohol-related harms and addiction phenotypes in pre clinical models , CBD appears to have promise as a c and i date AUD pharmacotherapy .
This is further bolstered by the absence of abuse liability and its general tolerability .
There is substantial interest in the therapeutic potential of cannabidiol ( CBD ) , a nonpsychoactive cannabinoid found in plants of the genus Cannabis .
The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a c and i date pharmacotherapy for alcohol use disorder ( AUD ) .
Chronic administration of cannabidiol to healthy volunteers and epileptic patients.
In phase 1 of the study , 3 mg/kg daily of cannabidiol ( CBD ) was given for 30 days to 8 health human volunteers . Another 8 volunteers received the same number of identical capsules containing glucose as placebo in a double-blind setting . Neurological and physical examinations , blood and urine analysis , ECG and EEG were performed at weekly intervals . In phase 2 of the study , 15 patients suffering from secondary generalized epilepsy with temporal focus were r and omly divided into two groups . Each patient received , in a double-blind procedure , 200 - 300 mg daily of CBD or placebo . The drugs were administered for along as 4 1/2 months . Clinical and laboratory examinations , EEG and ECG were performed at 15- or 30-day intervals . Throughout the experiment the patients continued to take the antiepileptic drugs prescribed before the experiment , although these drugs no longer controlled the signs of the disease . All patients and volunteers tolerated CBD  very well and no signs of toxicity or serious side effects were detected on examination . 4 of the 8 CBD subjects remained almost free of convulsive crises throughout the experiment and 3 other patients demonstrated partial improvement in their clinical condition .  CBD was ineffective in 1 patient . The clinical condition of 7 placebo patients remained unchanged whereas the condition of 1 patient clearly improved . The potential use of CBD as an antiepileptic drug and its possible potentiating effect on other antiepileptic drugs are discussed
In both rodent and cell culture models , CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus .
In rodent models , CBD was found to attenuate alcohol-induced hepatotoxicity , specifically , alcohol-induced steatosis .
Finally , findings from pre clinical rodent models also indicate that CBD attenuates cue-elicited and stress-elicited alcohol seeking , alcohol self-administration , withdrawal-induced convulsions , and impulsive discounting of delayed rewards .
In human studies , CBD was well tolerated and did not interact with the subjective effects of alcohol .
Collectively , given its favorable effects on alcohol-related harms and addiction phenotypes in pre clinical models , CBD appears to have promise as a c and i date AUD pharmacotherapy .
This is further bolstered by the absence of abuse liability and its general tolerability .
There is substantial interest in the therapeutic potential of cannabidiol ( CBD ) , a nonpsychoactive cannabinoid found in plants of the genus Cannabis .
The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a c and i date pharmacotherapy for alcohol use disorder ( AUD ) .