In conclusion , bariatric surgery is associated with a reduction in specific adipokines including leptin , chemerin , and PAI-1 , whereas adiponectin is raised , adaptations that could be indicative of improved fat mass and function
Different adipokines secreted from adipose tissue , exert a range of physiological effects .
The aim of present systematic review and meta- analysis was to critically investigate the consequence of  bariatric surgery on circulating adipokines , that is , adiponectin , leptin , visfatin , resistin , plasminogen activator inhibitor , and chemerin .
Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin.
OBJECTIVE Soluble leptin receptor ( sOB-R ) represents the main binding site for leptin in human blood . The aim of this study was to investigate the relationship between leptin and soluble leptin receptor and the bound/free ratio after pronounced weight reduction . RESEARCH METHODS AND PROCEDURES A total of 18 morbidly obese women participated in this prospect i ve study . Subjects were examined for fat mass , leptin , and sOB-R concentrations before and 1 year after Swedish adjustable gastric b and ing . RESULTS Anthropomorphic measures displayed a significant reduction of body mass index [ ( 42.9 + /- 5.6 to 32.9 + /- 6.0 kg/m(2 ) ( mean + /- SD ) ] . Fat mass decreased from 56.3 + /- 9.0 to 33.9 + /- 12.5 kg . Plasma leptin concentration decreased from 44.6 + /- 18.0 to 20.0 + /- 13.1 ng/mL ( p < 0.001 ) , whereas the sOB-R levels increased from 11.1 + /- 3.6 to 16.6 + /- 6.0 U/mL after weight-reducing surgery . Thus , the sOB-R bound fraction of leptin increased from 7 % to 33 % . DISCUSSION This work demonstrates a relationship between weight loss , leptin , and sOB-R concentrations in vivo . During weight loss , leptin levels decreased , whereas sOB-R levels and the receptor bound fraction of leptin increased . Thus , sOB-R may negatively regulate free leptin
In conclusion , bariatric surgery is associated with a reduction in specific adipokines including leptin , chemerin , and PAI-1 , whereas adiponectin is raised , adaptations that could be indicative of improved fat mass and function
Different adipokines secreted from adipose tissue , exert a range of physiological effects .
The aim of present systematic review and meta- analysis was to critically investigate the consequence of  bariatric surgery on circulating adipokines , that is , adiponectin , leptin , visfatin , resistin , plasminogen activator inhibitor , and chemerin .