In conclusion , bariatric surgery is associated with a reduction in specific adipokines including leptin , chemerin , and PAI-1 , whereas adiponectin is raised , adaptations that could be indicative of improved fat mass and function
Different adipokines secreted from adipose tissue , exert a range of physiological effects .
The aim of present systematic review and meta- analysis was to critically investigate the consequence of  bariatric surgery on circulating adipokines , that is , adiponectin , leptin , visfatin , resistin , plasminogen activator inhibitor , and chemerin .
Incidence and Predictors of Hypoglycemia 1 Year After Laparoscopic Sleeve Gastrectomy
Introduction Hypoglycemia is a known adverse event following gastric bypass . The incidence of hypoglycemia after  laparoscopic sleeve gastrectomy ( LSG )  is still under investigation . The aim of our study was to verify the presence of oral glucose tolerance test (OGTT)-related hypoglycemia after LSG and to identify any baseline predictors of its occurrence . Methods We analyzed 197 consecutive non-diabetic morbid obese patients that underwent LSG .  All patients were studied before and 12 months after LSG . Evaluation included anthropometric parameters , 3-h OGTT for blood glucose ( BG ) , insulin and c-peptide , lipid profile , interleukin-6 ( IL-6 ) , tumor necrosis factor alpha ( TNF-α ) , highly sensitive C-reactive protein ( hsCRP ) , and leptin . Hypoglycemia was defined as BG ≤ 2.7 mmol/l . Results After surgery , 180 patients completed the OGTT . Eleven patients did not complete the test for gastric intolerance , and in six patients , the test was stopped earlier for the onset of severe symptomatic hypoglycemia . Of the patients , 61/186 ( 32.8 % ) had at least one OGTT-related hypoglycemia . The highest frequency of hypoglycemic events occurred 150′ after glucose load ( 20.2 % ) . At baseline , patients with hypoglycemic events after surgery ( Hypo ) were younger ( 40 ± 11 vs 46 ± 10 years ; p < 0.001 ) , less obese ( BMI 46 ± 5.7 vs 48.4 ± 7.9 kg/m2 ; p < 0.05 ) , and had a worse lipid profile as compared to patients without hypoglycemic events ( N-Hypo ) . Moreover , after LSG , Hypo patients compared with N-Hypo presented a higher weight loss ( % E BMI L 80 ± 20 vs 62 ± 21 % ; p < 0.001 ) . Low age , low fasting glucose , and high triglyceride levels before LSG were independent predictors of hypoglycemia development after surgery ( r2 = 0.131 ) . Conclusion These findings confirm the high incidence of post-pr and ial hypoglycemia 1 year after LSG . Hypoglycemia is more frequent in younger patients with lower fasting glucose and higher triglyceride levels before surgery
In conclusion , bariatric surgery is associated with a reduction in specific adipokines including leptin , chemerin , and PAI-1 , whereas adiponectin is raised , adaptations that could be indicative of improved fat mass and function
Different adipokines secreted from adipose tissue , exert a range of physiological effects .
The aim of present systematic review and meta- analysis was to critically investigate the consequence of  bariatric surgery on circulating adipokines , that is , adiponectin , leptin , visfatin , resistin , plasminogen activator inhibitor , and chemerin .