Conclusion : Low folate and B12 serum levels seem to be associated with  depression in the aged .
Objectives : To systematic ally review and meta-analyse existing evidence on the association between folate/B12 , and depression among the aged people .
Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression.
OBJECTIVE In the present study , we assessed the relationship between serum folate , vitamin B12 , and homocysteine levels and clinical response in patients with major depressive disorder ( MDD ) who had previously failed to respond to open treatment with fluoxetine 20 mg/day and were enrolled in a 4-week , double-blind trial of either ( 1 ) fluoxetine dose increase , ( 2 ) lithium augmentation of fluoxetine , or ( 3 ) desipramine augmentation of fluoxetine . METHOD Fifty-five out patients ( mean + /- SD age = 41.7 + /- 10.6 years ; 50.9 % women ) with MDD as assessed with the Structured Clinical Interview for DSM-III-R who were enrolled in the double-blind trial had  serum folate , vitamin B12 , and homocysteine measurements completed at baseline ( prior to fluoxetine treatment initiation ) . Folate levels were classified as either low ( < or = 2.5 ng/mL ) or normal . Vitamin B12 levels were classified as either low ( < or = 200 pg/mL ) or normal . Homocysteine levels were classified as either elevated ( > or = 13.2 micromol/L ) or normal . With the use of a logistic regression , we then assessed the relationship between ( 1 ) low or normal folate levels , ( 2 ) normal or low B12 levels , and ( 3 ) elevated or normal homocysteine levels and clinical response to double-blind treatment . The study was conducted from November 1992 to January 1999 . RESULTS Low serum folate levels ( chi2=3.626 , p = .04 ) , but not elevated homocysteine ( p > .05 ) or low vitamin B12 levels ( p > .05 ) , were associated with poorer response to treatment . The response rates for patients with ( N = 14 ) and without ( N = 38 ) low folate levels were 7.1 % versus 44.7 % , respectively . CONCLUSION Low serum folate levels were found to be associated with further treatment resistance among patients with fluoxetine-resistant MDD
Conclusion : Low folate and B12 serum levels seem to be associated with  depression in the aged .
Objectives : To systematic ally review and meta-analyse existing evidence on the association between folate/B12 , and depression among the aged people .