Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effect of combined maternal and infant vitamin D supplementation on vitamin D status of exclusively breastfed infants.
Severe vitamin D deficiency in mothers and their breastfed infants is a significant health problem in the Middle East . Supplementation of the breastfed infant alone with the recommended dose of vitamin D may be insufficient in high-risk population . We investigated the effect of combined maternal and infant vitamin D supplementation on vitamin D status of the breastfed infant . We examined also the effect of supplementation on vitamin D antirachitic activity of breast milk in a subset of mothers . Healthy breastfeeding mothers ( n = 90 ) were r and omly assigned to 2000 IU daily ( group 1 ) or 60,000 IU monthly ( group 2 ) of vitamin D(2 ) , and all their infants ( n = 92 ) received 400 IU daily of vitamin D(2 ) for 3 months . Most infants had vitamin D deficiency - 25-hydroxyvitamin D [ 25(OH)D ] < or= 37.5 nmol L(-1)- at study entry .  Serum 25(OH)D concentrations at 3 months increased significantly from baseline in infants of mothers in group 1 ( 13.9 + /- 8.6 vs. 49.6 + /- 18.5 nmol L(-1 ) , P < 0.0001 ) and group 2 ( 13.7 + /- 12.1 vs. 44.6 + /- 15.0 nmol L(-1 ) , P < 0.0001 ) . Maternal and infant serum 25(OH)D concentrations correlated positively at baseline ( r = 0.36 , P = 0.01 ) and 3 months ( r = 0.46 , P = 0.002 ) . Milk antirachitic activity increased from undetectable ( < 20 IU L(-1 ) ) to a median of 50.9 IU L(-1 ) . In conclusion , combined maternal and infant vitamin D supplementation was associated with a threefold increase in infants ' serum 25(OH)D concentrations and a 64 % reduction in the prevalence of vitamin D deficiency without causing hypervitaminosis
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .