Despite limitations in these data , our NMA findings are in line with existing evidence on the metabolic effects of fat and support current recommendations to replace high saturated-fat food with unsaturated oils
The aim of this network meta- analysis ( NMA ) is to compare the effects of different oils/solid fats on blood lipids .
Substitution of vegetable oil for a partially-hydrogenated fat favorably alters cardiovascular disease risk factors in moderately hypercholesterolemic postmenopausal women.
OBJECTIVE Compared to vegetable oils in their unmodified state , partially-hydrogenated fat is associated with less favorable effects on cardiovascular disease ( CVD ) risk factors . Acceptable alternatives must be adjudicated . Our objective was to assess the effect of a recent commercial fat substitution , corn oil for partially-hydrogenated soybean oil . METHODS Using a double-blind cross-over design , 30 postmenopausal women > or=50 years with LDL-cholesterol concentrations > or=120 mg/dL were r and omly assigned to each of two 35-day phases ; all food and beverage was provided to maintain body weight . Corn or partially-hydrogenated soybean oil was incorporated throughout the diet and contributed two-thirds of fat . Primary outcomes included fasting and non-fasting lipid , lipoprotein , apolipoprotein , and fasting high sensitivity C-reactive protein ( hsCRP ) concentrations ; secondary outcomes included fasting small dense LDL (sdLDL)-cholesterol , remnant lipoprotein cholesterol ( RemLC ) , glycated albumin , adiponectin and immunoreactive insulin concentrations , and endogenous cholesteryl ester transfer protein ( CETP ) and lecithin : cholesterol acyl transferase ( LCAT ) activities . RESULTS Relative to the partially-hydrogenated soybean oil enriched diet , the corn oil enriched diet result ed in lower fasting total cholesterol ( 7 % ; P<0.0001 ) , LDL-cholesterol ( 10 % ; P<0.0001 ) , VLDL-cholesterol ( 7 % ; P=0.052 ) , apo B ( 9 % ; P<0.0001 ) , lipoprotein ( a ) [ Lp(a ) ] ( 5 % ; P=0.024 ) , sdLDL-cholesterol ( 17 % ; P=0.001 ) , and RemLC ( 20 % ; P=0.007 ) concentrations , and no significant effect on the other outcomes . Changes in postpr and ial ( 4-h post-meal ) lipid , lipoprotein and apolipoprotein concentrations were similar to the fasting state . CONCLUSION The replacement of partially-hydrogenated soybean oil with corn oil favorably affects a range of CVD risk factors and is an appropriate option to decrease cardiovascular disease risk factors in moderately hypercholesterolemic individuals
Despite limitations in these data , our NMA findings are in line with existing evidence on the metabolic effects of fat and support current recommendations to replace high saturated-fat food with unsaturated oils
The aim of this network meta- analysis ( NMA ) is to compare the effects of different oils/solid fats on blood lipids .