There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Prevention of asthma during the first 5 years of life: a randomized controlled trial.
BACKGROUND Early life exposures may be important in the development of asthma and allergic disease . OBJECTIVE To test house dust mite ( HDM ) avoidance and dietary fatty acid modification , implemented throughout the first 5 years of life , as interventions to prevent asthma and allergic disease . METHODS We recruited newborns with a family history of asthma antenatally and r and omized them , separately , to HDM avoidance or control and to dietary modification or control . At age 5 years , they were assessed for asthma and eczema and had skin prick tests for atopy . RESULTS Of 616 children r and omized , 516 ( 84 % ) were evaluated at age 5 years . The HDM avoidance intervention result ed in a 61 % reduction in HDM allergen concentrations ( microg/g dust ) in the child 's bed but no difference in the prevalence of asthma , wheeze , or atopy ( P > .1 ) . The prevalence of eczema was higher in the active HDM avoidance group ( 26 % vs 19 % ; P = .06 ) . The ratio of omega-6 to omega-3 fatty acids in plasma was lower in the active diet group ( 5.8 vs 7.4 ; P < .0001 ) . However , the prevalence of asthma , wheezing , eczema , or atopy did not differ between the diet groups ( P > .1 ) . CONCLUSION Further research is required to establish whether other interventions can be recommended for the prevention of asthma and allergic disease . CLINICAL IMPLICATION S House dust mite avoidance measures and dietary fatty acid modification , as implemented in this trial during infancy and early childhood , did not prevent the onset of asthma , eczema , or atopy in high-risk children
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .