Intensive glycaemic control does not seem to reduce all cause mortality in patients with type 2 diabetes .
OBJECTIVE To assess the effect of targeting intensive glycaemic control versus conventional glycaemic control on  all cause mortality and cardiovascular mortality , non-fatal myocardial infa rct ion , microvascular complications , and severe hypoglycaemia in patients with type 2 diabetes .
The influences of obesity and glycemic control on endothelial activation in patients with type 2 diabetes.
The aims of this study were to eluci date the factors that contribute to endothelial activation and fibrinolytic abnormalities in patients with poorly controlled type 2 diabetes and to determine whether improved glycemic control reduces endothelial activation . Adhesion molecules [ E-selectin , intracellular adhesion molecule-1 ( ICAM-1 ) , and vascular cell adhesion molecule-1 ] , von Willebr and factor , total nitric oxide ( NO ) , endothelin-1 , tissue plasminogen activator , and plasminogen activator inhibitor-1 were measured in 43 type 2 diabetic subjects with hemoglobin A1c of 9.0 % or more at baseline ( compared with 21 healthy controls ) who after 20 wk had been r and omized to either improved ( IC ) or usual ( UC ) glycemic control . At baseline , type 2 diabetic patients had significant endothelial activation and abnormal fibrinolysis compared with control subjects . Body mass index in the diabetic patients was the only independent predictor of E-selectin ( P = 0.007 ) , ICAM-1 ( P = 0.01 ) , and NO ( P = 0.008 ) concentrations , but not vascular cell adhesion molecule-1 , plasminogen activator inhibitor-1 , or tissue plasminogen activator ( all P > 0.05 ) . Type 2 diabetic patients with a body mass index of 28 kg/m2 or less had concentrations of E-selectin , ICAM-1 , endothelin-1 , and NO similar to those in healthy controls . After 20 wk , hemoglobin A1c was significantly lower in IC vs. UC ( IC , 8.02 + /- 0.25 % ; UC , 10.23 + /- 0.23 % ; P < 0.0001 ) , but there were no significant changes in markers of endothelial activation or indexes of fibrinolysis . Obesity appears to be the most important predictor of endothelial activation in patients with type 2 diabetes . Short-term improvement in glycemic control does not appear to reduce endothelial activation
Intensive glycaemic control does not seem to reduce all cause mortality in patients with type 2 diabetes .
OBJECTIVE To assess the effect of targeting intensive glycaemic control versus conventional glycaemic control on  all cause mortality and cardiovascular mortality , non-fatal myocardial infa rct ion , microvascular complications , and severe hypoglycaemia in patients with type 2 diabetes .