There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Fatty acid balance studies in preterm infants fed formula milk containing long‐chain polyunsaturated fatty acids (LCP) II
A milk formula ( Prematil‐LCP ) containing long‐chain polyunsaturated fatty acids ( LCP ) and with a fatty acid profile closely resembling breast milk has recently been introduced for preterm infants . A double‐blind r and omized controlled trial was performed comparing fatty acid absorption from Prematil‐LCP ( n= 10 ) and st and ard Prematil ( n= 10 ) . Formula‐fed preterm infants underwent 3 d fat balances ( once full enteral feeds were established ) along with a parallel human milk fed group ( n= 11 ) . Plasma sample s were taken on the last day . Median total fat excretion ( absorption , % ) was 2.34 g kg ( 82.0 ) , 2.64 g kg ( 82.9 ) and 1.65 g kg ( 87.8 ) with Prematil , Prematil‐LCP and human milk feeding , respectively . This reflected differences in the excretion and absorption of long‐chain saturated fatty acids . All groups excreted detectable LCP . LCP disappearance was higher in infants fed human milk than in those fed Prematil‐LCP , particularly for n‐6 LCP ( p < 0:01 ) . Nevertheless , excreted LCP equated to < 30 % dietary intake , with Prematil‐LCP feeding . Plasma lipid fatty acid composition reflected differences in dietary LCP intake
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .