Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .
Alpha-lipoic acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes.
BACKGROUND Oxidative stress plays an important role in the development of diabetic cardiomyopathy . Alpha-lipoic acid ( ALA ) is a powerful antioxidant that may have a protective role in diabetic cardiac dysfunction . AIM We investigated the possible beneficial effect of alpha-lipoic acid on diabetic left ventricular ( LV ) dysfunction in children and adolescents with asymptomatic type 1 diabetes ( T1D ) . SUBJECTS AND METHODS Thirty T1D patients ( aged 10 - 14 ) were r and omized to receive insulin treatment ( n = 15 ) or insulin plus alpha-lipoic acid 300 mg twice daily ( n = 15 ) for four months . Age and sex matched healthy controls ( n = 15 ) were also included . Patients were evaluated with conventional 2-dimensional echocardiographic examination ( 2D ) , pulsed tissue Doppler ( PTD ) , and 2-dimensional longitudinal strain echocardiography ( 2DS ) before and after therapy .  Glutathione , malondialdhyde ( MDA ) , nitric oxide ( NO ) , tumor necrosis factor-alpha ( TNF-alpha ) , Fas lig and ( Fas-L ) , matrix metalloproteinase 2 ( MMP-2 ) , and troponin-I were determined and correlated to echocardiographic parameters . RESULTS Diabetic patients had significantly lower levels of glutathione and significantly higher MDA , NO , TNF-alpha , Fas-L , MMP-2 , and troponin-I levels than control subjects . The expression of transforming growth factor beta ( TGF-beta ) mRNA in peripheral blood mononuclear cells was also increased in diabetic patients . Significant correlations of mitral e'/a ' ratio and left ventricular global peak systolic strain with glutathione , MDA , NO , TNF-alpha , and Fas-L were observed in diabetic patients . Alpha-lipoic acid significantly increased glutathione level and significantly decreased MDA , NO , TNF-alpha , Fas-L , MMP-2 , troponin-I levels , and TGF-beta gene expression . Moreover , alpha-lipoic acid significantly increased mitral e'/a ' ratio and left ventricular global peak systolic strain in diabetic patients . CONCLUSION These findings suggest that alpha-lipoic acid may have a role in preventing the development of diabetic cardiomyopathy in type 1 diabetes
Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .