On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Levoamphetamine vs dextroamphetamine in minimal brain dysfunction. Replication, time response, and differential effect by diagnostic group and family rating.
Double-blind crossover r and omized Latin square comparison of placebo , dextroamphetamine , and levoamphetamine in 31 consecutively diagnosed children with minimal brain dysfunction ( MBD ) replicated a smaller nonr and om study . Both isomers showed significantly more benefit than placebo but were not significantly different from each other . Dextroamphetamine showed a nonsignificant trend of superiority over levoamphetamine . Of 25 subjects who responded well to drugs , three responded only to levoamphetamine , five only to dextroamphetamine , and 17 to both . This study seems to confirm the efficacy of levoamphetamine in MBD . An unsocialized aggressive subgroup ( 308.4 ) showed a nonsignificant trend for  levoamphetamine superiority , in contrast to the hyperkinetic ( 308.0 ) and overanxious ( 308.2 ) subgroups . Those who responded best to levoamphetamine tended ( not significantly ) to be from poorer functioning families . Parents ' ratings , but not teachers ' or psychiatrists ' ratings , showed significant placebo effect
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .