Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure
Recent studies suggest that chlorogenic acids , which are the main components of the polyphenol class in coffee , decrease blood pressure , and that hydroxyhydroquinone ( HHQ ) , which is generated by roasting coffee beans , inhibits the antihypertensive effect of chlorogenic acids in brewed coffee . Here , we examined the vasoreactivity and antihypertensive effects of HHQ-reduced coffee in mild hypertension . The study design was a double blind , r and omized , placebo-controlled intervention study , with a 4-week run-in period , followed by an 8-week test beverage ingestion period . The subjects were Japanese men and women with mild hypertension and vascular failure , who were not taking any antihypertensive drugs . During the test beverage ingestion period , the subjects ingested either active or placebo HHQ-reduced coffee ( chlorogenic acids per 184 ml of coffee : active , 300 mg ; and placebo , 0 mg ) daily . Subjects were r and omly divided into two groups : active group ( n=9 ) and placebo group ( n=12 ) . In the active beverage group , endothelium-dependent , flow-mediated vasodilation impairment was significantly ameliorated and systolic blood pressure was significantly decreased from the baseline , but not in the placebo group . There were no test beverage consumption-related changes in other parameters that may influence blood pressure , such as pulse , cardiac output , body weight or 24-h urine volume . Ingestion of the active beverage significantly decreased urinary isoprostane levels , suggesting a reduced oxidative stress . These findings indicate that HHQ-reduced coffee decreased blood pressure in subjects with mild hypertension . The decreased blood pressure was associated with improved vascular endothelial function
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .