Inflammation appeared to be associated with greater loss of muscle strength .
There was inconclusive evidence that the level of physical activity affects change in skeletal muscle .
In regard to the effect of interventions , only exercise interventions were consistently associated with improved skeletal muscle outcomes .
CONCLUSIONS Adult patients who undergo an unplanned hospital admission may experience a small reduction in knee extension strength and mid-arm muscle mass .
OBJECTIVES The primary objective of the review was to describe change that occurs in skeletal muscle during periods of unplanned hospitalisation in adult patients .
The secondary objective was to examine the relationship between both physical activity and inflammation with the change in skeletal muscle .
A further objective was to investigate the effect of interventions on change in skeletal muscle during periods of unplanned hospitalisation .
Physical and Functional Impairment During and After Hospitalization in Subjects With Severe COPD Exacerbation
BACKGROUND : COPD exacerbations are frequent events that have a negative impact on the lives of patients . The aims of this study were to analyze physical and functional impairment during hospital stay in subjects hospitalized due to COPD exacerbation and to assess the physical and functional impact of hospitalization at a 1-month follow-up in patients with severe COPD . METHODS : This was a prospect i ve observational study on a sample of 52 subjects hospitalized due to COPD exacerbation . The assessment s were performed at baseline , discharge , and 1-month follow-up . The outcome measures were dyspnea , muscle strength , functional capacity , and postural steadiness . RESULTS : Quadriceps strength [ 1.036 ( P = .043 ) kg mean difference ] and the one-leg stance test [ 1.04 ( P = .02 ) and 0.73 ( P = .032 ) s mean difference right and left leg ] showed significant impairment during hospitalization . Dyspnea perception improved significantly ( P = .004 ) during hospitalization . Additionally , strength in the upper and lower limbs [ 4.04 ( P = .002 ) and 1.23 ( P = .038 ) kg mean difference ] , functional capacity [ 3.0 number of steps mean difference ( P = .032 ) ] , and the one-leg stance test [ 2.12 ( P = .006 ) and 0.53 ( P = .047 ) s mean difference right and left leg ] showed significant impairment 1-month follow-up . CONCLUSIONS : Hospitalization due to COPD exacerbation leads to physical and functional impairment in patients ; impairment is greater at 1-month follow-up . It would be interesting to conduct physical therapy interventions to prevent the impairment
Inflammation appeared to be associated with greater loss of muscle strength .
There was inconclusive evidence that the level of physical activity affects change in skeletal muscle .
In regard to the effect of interventions , only exercise interventions were consistently associated with improved skeletal muscle outcomes .
CONCLUSIONS Adult patients who undergo an unplanned hospital admission may experience a small reduction in knee extension strength and mid-arm muscle mass .
OBJECTIVES The primary objective of the review was to describe change that occurs in skeletal muscle during periods of unplanned hospitalisation in adult patients .
The secondary objective was to examine the relationship between both physical activity and inflammation with the change in skeletal muscle .
A further objective was to investigate the effect of interventions on change in skeletal muscle during periods of unplanned hospitalisation .