In general , studies suggest that root canal sealers elicit mild to severe toxic effects and that several factors may influence biocompatibility , e.g. , material setting condition and time , material concentration , and type of exposure .
4 ) Conclusions : The available evidence shows that root canal sealers exhibit variable toxic potential at the cellular and tissue level .
However , the method ological heterogeneity among studies included in this systematic review and the somewhat conflicting results do not allow a conclusion on which type of sealer presents higher biocompatibility .
( 1 ) Aim : To perform a systematic review of the literature on the biocompatibility of  root canal sealers  that encompasses the various types of sealers that are commercially available as well as both in vitro and in vivo evidence . (
Guidelines for reporting pre-clinical in vitro studies on dental materials.
In vitro pre- clinical research is an important aspect of the development of new dental material s and techniques , because it can provide essential information for further testing of therapeutic approaches in clinical trials . These pre- clinical experiments should therefore be reported with the same rigor as studies involving humans . The objectives of this paper were twofold : ( a ) to search and assess existing guidelines for reporting in vitro studies in dentistry , and ( b ) to present a methodology for reporting these studies , based on the CONSORT checklist for reporting r and omized clinical trials . After a comprehensive search in PubMed data base , no guidelines for reporting in vitro studies in dentistry were found . The proposed methodology is presented and the rationale for the choice of fourteen guidelines for producing the different sections of such papers is described in detail . The assessment of a sample of in vitro studies using the proposed guidelines showed that the st and ards of reporting should be improved . Good st and ards of reporting of studies are necessary for improvement of efficiency in dental research . The guidelines presented are the first st and ards for reporting in vitro studies in dentistry . As with the original CONSORT document , the modified checklist is evolving . It should , therefore , be further tested by research ers and the results of these assessment s should be used for further improvement of this tool
In general , studies suggest that root canal sealers elicit mild to severe toxic effects and that several factors may influence biocompatibility , e.g. , material setting condition and time , material concentration , and type of exposure .
4 ) Conclusions : The available evidence shows that root canal sealers exhibit variable toxic potential at the cellular and tissue level .
However , the method ological heterogeneity among studies included in this systematic review and the somewhat conflicting results do not allow a conclusion on which type of sealer presents higher biocompatibility .
( 1 ) Aim : To perform a systematic review of the literature on the biocompatibility of  root canal sealers  that encompasses the various types of sealers that are commercially available as well as both in vitro and in vivo evidence . (