Quantitative relations between baseline iron status , study duration , and iron dose on changes in iron-status biomarkers , which were generated from the meta-analyses , can be used to predict effects of trials of iron supplementation and fortification and to design iron-intervention programs
BACKGROUND The response of status biomarkers to an increase in iron supply depends on several physiologic and environmental factors , which make it difficult to predict the outcome of an intervention .
OBJECTIVE We assessed effects of baseline iron status , sex , menopausal status , duration of intervention , iron form , and daily dose on the change in iron status in response to iron supplementation .
Prevalence and type of anaemia in female cotton mill workers in Beijing, China.
The present study investigates the prevalence and type of anaemia in Chinese female cotton mill workers . The prevalence of anaemia is reported in 447 non-pregnant female workers aged between 19 and 45 years . The mean value for haemoglobin ( Hb ) was 123 ( SD 15 ) g/l and 150 of the total 447 subjects had Hb values below 120 g/l ; thus 34 % of the population was anaemic according to World Health Organization ( WHO , 1975 ) criteria . The mean value for free erythrocyte protoporphyrin ( FEP ) was 419 ( SD 215 ) micrograms/l ; 55 % of the total population had FEP values higher than 350 micrograms/l and 72 % among the anaemic subjects . Serum ferritin ( SF ) was tested in all the women with a Hb value less than 120 g/l and 71 % of them had SF values below 12.0 micrograms/l . Eighty women diagnosed as either Fe deficient or with Fe-deficient anaemia were selected for a diagnostic supplementation trial . They were r and omly assigned to FeSO4 ( 60 or 120 mg Fe/d ) or placebo treatment for 12 weeks . Fe supplementation increased mean Hb values from 114 to 127 g/l ( P < 0.001 ) and SF levels from 9.7 to 30.0 micrograms/l ( P < 0.001 ) , and decreased mean FEP values from 570 to 277 micrograms/l ( P < 0.001 ) . The response rate of Hb in the whole Fe-treated group or Fe-treated subjects with an Hb level less than 120 g/l was 90 % or 92 % respectively . These findings indicate that the type of anaemia in this population was mainly Fe deficiency . It was also found that in this population the severity of anaemia , not the prevalence , was significantly related to the use of intra-uterine devices ( IUD )
Quantitative relations between baseline iron status , study duration , and iron dose on changes in iron-status biomarkers , which were generated from the meta-analyses , can be used to predict effects of trials of iron supplementation and fortification and to design iron-intervention programs
BACKGROUND The response of status biomarkers to an increase in iron supply depends on several physiologic and environmental factors , which make it difficult to predict the outcome of an intervention .
OBJECTIVE We assessed effects of baseline iron status , sex , menopausal status , duration of intervention , iron form , and daily dose on the change in iron status in response to iron supplementation .