LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Steady‐state pharmacokinetics of fluvastatin in healthy subjects following a new extended release fluvastatin tablet, Lescol® XL
This was an open‐label , r and omized , three‐period , three‐treatment , multiple dose , crossover study in 12 healthy male and female subjects . This study evaluated single dose and steady‐state pharmacokinetics of fluvastatin following single and multiple dose administrations of a new extended release fluvastatin 8 h matrix tablet , Lescol ® XL 80 mg and 160 mg doses once a day . The study also included a twice a day administration of an immediate release ( IR ) form of fluvastatin capsule , Lescol ® , for comparative purpose s. All doses were administered for 7 days . The safety and tolerability were also assessed . The pharmacokinetics of fluvastatin  were evaluated on days 1 and 7 following each treatment . Fluvastatin systemic exposure was 50 % less when administered as Lescol ® XL 80 mg qd compared with Lescol ® IR 40 mg bid . Conversely , fluvastatin systemic exposure was 22 % higher when administered as Lescol ® XL 160 mg qd compared with Lescol ® IR 40 mg bid . Single doses of Lescol ® XL 80 mg and 160 mg were dose proportional but , deviation ( 30 % ) from dose proportionality was observed for the Lescol ® XL 160 mg at steady‐state . There appeared to be moderate ( 20%–40 % ) accumulation of serum fluvastatin maximal concentrations and exposure after multiple doses of Lescol ® XL tablets . Both Lescol ® XL 80 mg and 160 mg showed delayed absorption and longer apparent elimination half‐life compared with fluvastatin IR capsule . Single and multiple doses of fluvastatin were generally well tolerated in this healthy volunteer population .  Adverse event profiles were consistent with the published safety profile of the marketed formulations . Aside from one incidence of creatine phosphokinase ( CPK ) elevation ( following Lescol ® XL 160 mg qd treatment ) , there were no safety concerns with any of the treatments when administered acutely ( 7 days ) . Copyright © 2004 John Wiley & Sons ,
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .