Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Efficacy of daily and monthly high-dose calciferol in vitamin D-deficient nulliparous and lactating women.
BACKGROUND We previously found a high prevalence of vitamin D deficiency and low medication regimen compliance in Arab and East Indian women residing in the United Arab Emirates ( UAE ) . The appropriate dosing regimen for improving vitamin D status in this population is not known . OBJECTIVE We aim ed to determine the efficacy of daily and monthly supplementation with vitamin D2 , the only high-dose calciferol available in the UAE , in lactating and nulliparous women . DESIGN Healthy lactating ( n = 90 ) and nulliparous ( n = 88 ) women were r and omly assigned to consume 2000 IU vitamin D2/d or 60,000 IU vitamin D2/mo for 3 mo . Serum 25-hydroxyvitamin D [ 25(OH)D ] concentrations were measured by radioimmunoassay at baseline and every month . RESULTS Most women had vitamin D deficiency [ ie , 25(OH)D < 50 nmol/L ] at study entry . Mean + /- SD 25(OH)D concentrations at 3 mo were significantly higher than baseline in both lactating ( 39.8 + /- 12.4 and 25.2 + /- 10.7 nmol/L , respectively ) and nulliparous ( 40.4 + /- 23.4 and 19.3 + /- 12.2 nmol/L , respectively ) women ( P < 0.001 for both ) . In total , vitamin D supplementation was effective in achieving serum 25(OH)D concentrations of > or=50 nmol/L in 21 ( 30 % ) of 71 women at endpoint . CONCLUSIONS Oral vitamin D2 supplementation with 2000 IU/d or 60,000 IU/mo for 3 mo was safe , and it increased serum 25(OH)D concentrations significantly ; however , only a small proportion of the women studied achieved concentrations of > or=50 nmol/L. This suggests that , when sunlight exposure is limited , doses of vitamin D2 higher than those currently studied may be needed . Monthly dosing appears to be a safe and effective alternative to daily dosing
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .