Conclusion Our study demonstrates potential beneficial effects of probiotics on inflammation , uremic toxins , and GI Symptoms in ESRD patients .
Background / Objectives We performed this systematic review and meta- analysis to evaluate effects of probiotics on inflammation , uremic toxins , and gastrointestinal ( GI ) symptoms in end-stage renal disease ( ESRD ) patients .
Biomodulation of the toxic and nutritional effects of small bowel bacterial overgrowth in end-stage kidney disease using freeze-dried Lactobacillus acidophilus.
Small bowel bacterial overgrowth ( SBBO ) , well known to occur in end-stage kidney failure , is responsible for producing uremic toxins and contributing to the patient 's decreased nutritional well-being . In this study , 8 hemodialysis patients were treated with a course of oral Lactobacillus acidophilus ( LBA ) in an attempt to alter this SBBO . LBA treatment was effective in lowering 2 compounds generated in vivo . Serum dimethylamine ( DMA ) levels dropped from 224 + /- 47 to 154 + /- 47 micrograms/dl at the end of LBA treatment ( p < 0.001 ) . Nitrosodimethylamine , a carcinogen , levels also decreased significantly from 178 + /- 67 ( untreated ) to 83 + /- 49 ng/kg ( after LBA treatment ) . Patients nutritional status , assessed as serum albumin , body weight , caloric intake , midarm muscle area ( MAMA ) and appetite improved modestly , but not significantly . LBA changed small bowel pathobiology by modifying metabolic actions of SBBO , reducing in vivo generation of toxins and carcinogens and promoting nutrition with no adverse side effects
Conclusion Our study demonstrates potential beneficial effects of probiotics on inflammation , uremic toxins , and GI Symptoms in ESRD patients .
Background / Objectives We performed this systematic review and meta- analysis to evaluate effects of probiotics on inflammation , uremic toxins , and gastrointestinal ( GI ) symptoms in end-stage renal disease ( ESRD ) patients .