In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension.
AIMS Stevioside is a natural plant glycoside isolated from the plant Stevia rebaudiana which has been commercialized as a sweetener in Japan for more than 20 years . Previous animal studies have shown that stevioside has an antihypertensive effect . This study was to design ed to evaluate the effect of stevioside in human hypertension . METHODS A multicentre , r and omized , double-blind , placebo-controlled study was undertaken . This study group consisted of 106 Chinese hypertensive subjects with diastolic blood pressure between 95 and 110 mmHg and ages ranging from 28 to 75 years with 60 subjects ( men 34 , women 26 ; mean + /- s.d . , 54.1+/-3.8 years ) allocated to active treatment and 46 ( men 19 , women 27 ; mean + /- s.d . , 53.7+/-4.1 years ) to placebo treatment . Each subject was given capsules containing stevioside ( 250 mg ) or placebo thrice daily and followed-up at monthly intervals for 1 year . RESULTS After 3 months , the systolic and diastolic blood pressure of the stevioside group decreased significantly ( systolic : 166.0+/-9.4 - 152.6+/-6.8 mmHg ; diastolic : 104.7 + /- 5.2 - 90.3+/-3.6 mmHg , P<0.05 ) , and the effect persisted during the whole year . Blood biochemistry parameters including lipid and glucose showed no significant changes . No significant adverse effect was observed and quality of life assessment showed no deterioration . CONCLUSIONS This study shows that oral stevioside is a well tolerated and effective modality that may be considered as an alternative or supplementary therapy for patients with hypertension
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .