Once-daily dihydropyridine calcium channel blockers appeared to lower blood pressure by a relatively constant amount throughout the 24-hour dosing interval .
Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours .
BACKGROUND Calcium channel blockers are a heterogeneous class of drugs , including dihydropyridine and non-dihydropyridine subgroups , commonly used in the treatment of hypertension .
A systematic review of the 24-hour time course of the blood pressure-lowering effect has not been published .
OBJECTIVES To assess how much variation there is in hourly systolic and diastolic blood pressure lowering by dihydropyridine calcium channel blockers over a 24-hour period in people with hypertension aged 18 years or over , with baseline systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg , or both .
Arterial and Antihypertensive Effects of Nitrendipine: A Double-Blind Comparison Versus Placebo
Summary : Arterial effects evaluated by carotid-femoral , brachial-radial , and femoral-tibial pulse wave velocity and antihypertensive effect evaluated by 24-h ambulatory blood pressure ( BP ) monitoring were measured in 17 hypertensive patients before and 24 h after once-daily nitrendipine ( 20 mg ) administration . After a 15-day placebo period , a double-blind study of nitrendipine versus placebo was performed for 1 month . After nitrendipine dosing , BP measured by sphygmomanometer 24 h after the last drug intake showed a significant decrease as compared with the pretreatment period . Ambulatory BP mean values were also significantly decreased for systolic and diastolic BP ( SBP , DBP ) . This decrease predominated during the day but was observed nocturnally only after 6 a.m. Twenty-four hours after the last tablet intake of nitrendipine , carotid-femoral and brachial-radial pulse wave velocities were significantly reduced , whereas femoral-tibial wave velocity was unchanged , indicating that markers of arterial rigidity might be substantially modified and that the modifications were partly unrelated to BP changes . The results provide evidence that in hypertensive subjects nitrendipine 20 mg given once daily for 1 month produces an arterial effect for 24 h , in association with BP reduction
Once-daily dihydropyridine calcium channel blockers appeared to lower blood pressure by a relatively constant amount throughout the 24-hour dosing interval .
Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours .
BACKGROUND Calcium channel blockers are a heterogeneous class of drugs , including dihydropyridine and non-dihydropyridine subgroups , commonly used in the treatment of hypertension .
A systematic review of the 24-hour time course of the blood pressure-lowering effect has not been published .
OBJECTIVES To assess how much variation there is in hourly systolic and diastolic blood pressure lowering by dihydropyridine calcium channel blockers over a 24-hour period in people with hypertension aged 18 years or over , with baseline systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg , or both .