Combining 21 trials evaluating lipid outcomes , fish oil consumption result ed in a summary net change in triglycerides of -27 ( 95 % CI -33 , -20)mg/dL , in HDL cholesterol of + 1.6 ( 95 % CI + 0.8 , + 2.3)mg/dL , and in LDL cholesterol of + 6 ( 95 % CI + 3 , + 8)mg/dL. There was no effect of fish oil on total cholesterol .
Across studies , higher fish oil dose and higher baseline levels were associated with greater reductions in serum triglycerides .
The evidence supports a dose-dependent beneficial effect of fish oil on serum triglycerides , particularly among people with more elevated levels .
Fish oil consumption also modestly improves HDL cholesterol , increases LDL cholesterol levels , but does not appear to adversely affect glucose homeostasis .
The evidence regarding the effects of omega-3 fatty acids on hs-CRP is inconclusive , as are data on ALA
Greater fish oil consumption has been associated with reduced CVD risk , although the mechanisms are unclear .
Plant- source oil omega-3 fatty acids ( ALA ) have also been studied regarding their cardiovascular effect .
A prospective, randomized, and double-blind trial on the effect of fish oil on the incidence of restenosis following PTCA.
Restenosis after successful coronary angioplasty ( PTCA ) occurs in 25 - 35 % of all procedures . To date , most pharmacologic strategies have failed to reduce the restenosis rate significantly . However , recent studies have suggested a potential benefit of dietary supplementation with omega-3 fatty acids ( fish oil ) on restenosis following PTCA . The benefit of omega-3 polyunsaturated fatty acids on the incidence of coronary artery restenosis following elective PTCA was assessed in 212 consecutive patients ( 41 female , 171 male ) . Following a successful angioplasty , 204 patients received a dietary supplementation with either nine capsules containing fish oil ( 3.15 g omega-3 fatty acids ) or nine placebo capsules containing olive oil . Treatment was started immediately after PTCA and maintained over 4 mon . Compliance was assessed by analysis of lipid fatty acids prior to angioplasty and at 4 mon follow-up . The angiographically determined incidence of restenosis ( stenosis diameter > 50 % ) was 31.2 % per lesion in patients receiving fish oil and 33.7 % in patients receiving olive oil .  Gross progression of coronary artery disease in vessels not subjected to angioplasty was 17 % and 16 % , respectively . In conclusion , low dose fish oil supplementation begun on the day of a successful coronary angioplasty failed to demonstrate any effect on coronary artery restenosis
Combining 21 trials evaluating lipid outcomes , fish oil consumption result ed in a summary net change in triglycerides of -27 ( 95 % CI -33 , -20)mg/dL , in HDL cholesterol of + 1.6 ( 95 % CI + 0.8 , + 2.3)mg/dL , and in LDL cholesterol of + 6 ( 95 % CI + 3 , + 8)mg/dL. There was no effect of fish oil on total cholesterol .
Across studies , higher fish oil dose and higher baseline levels were associated with greater reductions in serum triglycerides .
The evidence supports a dose-dependent beneficial effect of fish oil on serum triglycerides , particularly among people with more elevated levels .
Fish oil consumption also modestly improves HDL cholesterol , increases LDL cholesterol levels , but does not appear to adversely affect glucose homeostasis .
The evidence regarding the effects of omega-3 fatty acids on hs-CRP is inconclusive , as are data on ALA
Greater fish oil consumption has been associated with reduced CVD risk , although the mechanisms are unclear .
Plant- source oil omega-3 fatty acids ( ALA ) have also been studied regarding their cardiovascular effect .