Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Effect of coffee on endothelial function in healthy subjects: the role of caffeine.
Coffee is one of the most widely used pharmacologically active beverages . The present study was design ed to evaluate the acute effect of coffee ingestion on endothelial function in healthy individuals , and the potential role of caffeine . We studied 17 healthy young adults ( 28.9+/-3.0 years old ; nine men ) , who were regular non-heavy coffee drinkers . The endothelial performance was estimated by endothelium-dependent FMD ( flow-mediated dilatation ) of the brachial artery before and 30 , 60 , 90 and 120 min after ingestion of a cup of caffeinated coffee ( 80 mg of caffeine ) or the corresponding decaffeinated beverage ( < 2 mg of caffeine ) in two separate sessions , following a r and omized single-blind cross-over design . There was no difference in baseline FMD values between the two sessions [ 7.78 compared with 7.07 % after caffeinated and decaffeinated coffee respectively ; P = NS ( not significant ) ] . Caffeinated coffee led to a decline of FMD ( 7.78 , 2.86 , 2.12 , 4.44 and 4.57 % at baseline , 30 , 60 , 90 and 120 min respectively ; P < 0.001 ) . This adverse effect was focused at 30 ( P = 0.004 ) and 60 min ( P < 0.001 ) . No significant effect on FMD was found with the decaffeinated coffee session ( 7.07 , 6.24 , 5.21 , 7.41 and 5.20 % ; P = NS ) . The composite effect of the type of coffee consumed over time on FMD was significantly different ( P = 0.021 ) . In conclusion , coffee exerts an acute unfavourable effect on the endothelial function  in healthy adults , lasting for at least 1 h after intake . This effect might be attributed to caffeine , given that decaffeinated coffee was not associated with any change in the endothelial performance
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .