Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Impact of acute caffeine ingestion on endothelial function in subjects with and without coronary artery disease.
Although coffee is a widely used , pharmacologically active beverage , its impact on the cardiovascular system is controversial . To explore the effect of acute caffeine ingestion on brachial artery flow-mediated dilation ( FMD ) in subjects without coronary artery disease ( CAD ; controls ) and patients with CAD , we prospect ively assessed brachial artery FMD in 40 controls and 40 age- and gender-matched patients with documented stable CAD on 2 separate mornings 1 week to 2 weeks apart . After overnight fasting , discontinuation of all medications for ≥12 hours , and absence of caffeine for > 48 hours , participants received capsules with caffeine 200 mg or placebo . One hour after drug ingestion , participants underwent brachial artery FMD and nitroglycerin-mediated dilation ( NTG ) using high-resolution ultrasound . As expected , patients with CAD were more often diabetic , hypertensive , obese , dyslipidemic , and smoked more than controls ( p < 0.01 for all comparisons ) . Aspirin , Clopidogrel , angiotensin-converting enzyme inhibitors , β blockers , and statins  were significantly more common in patients with CAD than in controls ( p < 0.01 for all comparisons ) . At baseline , FMD , but not NTG , was significantly lower in patients with CAD compared to controls . Acute caffeine ingestion significantly increased FMD ( patients with CAD 5.6 ± 5.0 % vs 14.6 ± 5.0 % , controls 8.4 ± 2.9 % vs 18.6 ± 6.8 % , p < 0.001 for all comparisons ) but not NTG ( patients with CAD 13.0 ± 5.2 % vs 13.8 ± 6.1 % , controls 12.9 ± 3.9 % vs 13.9 ± 5.8 % , p = NS for all comparisons ) and significantly decreased high-sensitivity C-reactive protein ( patients with CAD 2.6 ± 1.4 vs 1.4 ± 1.2 mg/L , controls 3.4 ± 3.0 vs 1.2 ± 1.0 mg/L , p < 0.001 for all comparisons ) in the 2 groups compared to placebo . In conclusion , acute caffeine ingestion significantly improved endothelial function assessed by brachial artery FMD in subjects with and without CAD and was associated with lower plasma markers of inflammation
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .