The results of the present meta- analysis support that melatonin supplementation could be effective on ameliorating of inflammatory mediators
Inflammatory processes are involved in chronic diseases .
It has been suggested that melatonin reduces inflammation by its radical scavenging properties ; however , the results of the previous studies are inconclusive .
The objective of the present meta- analysis is to determine the direction and magnitude of melatonin supplementation effect on inflammatory biomarkers .
The effect of melatonin on endothelial dysfunction in patient undergoing coronary artery bypass grafting surgery
Background : In this study , we investigated the effect of melatonin administration on four markers of endothelial cell function including intercellular adhesion molecule ( ICAM ) , vascular cell adhesion molecule ( VCAM ) , C-reactive protein ( CRP ) , and nitric oxide ( NO ) on patients with three vessels coronary disease . Material s and Methods : This double-blind , r and omized , controlled trial study was conducted on 39 patients ( 32 men and 7 women ) with three vessels coronary disease . The case group included 20 patients who received 10 mg oral melatonin 1 h before sleeping for 1 month . The control group included 19 patients who received placebo 1 h before sleeping for 1 month . The serum levels of CRP , ICAM , VCAM , and NO were compared after 1 month treatment . Results : After 1 month of melatonin treatment , the mean level of ICAM , VCAM , and CRP showed a statistically significant decrease in the case group . On the other h and , the mean level of VCAM increased significantly in the control group . The mean levels of CRP and ICAM were also increased in the control group , but the difference did not reach the significant threshold . With respect to NO , there was a statistically significant increase in the case group , while there was a statistically significant decrease in serum NO in the control group . Conclusions : The results of this study suggested that melatonin may have beneficial effects on endothelial oxidative stress even in patient with severe and advanced atherosclerosis
The results of the present meta- analysis support that melatonin supplementation could be effective on ameliorating of inflammatory mediators
Inflammatory processes are involved in chronic diseases .
It has been suggested that melatonin reduces inflammation by its radical scavenging properties ; however , the results of the previous studies are inconclusive .
The objective of the present meta- analysis is to determine the direction and magnitude of melatonin supplementation effect on inflammatory biomarkers .