The results indicated that there was no significant difference in the amelioration of BMI , HOMA-%S and HOMA-%B in T2DM patients between RS and the non-RS supplementation .
There was no significant difference between RS and non-RS supplements in patients with simple obesity .
Conclusion RS supplementation can ameliorate IR in T2DM , especially for the patients of T2DM with obesity , but not in simple obesity
Background Resistant starch ( RS ) is a starch that can be fermented by the microbial flora within gut lumen .
Insulin resistance ( IR ) is a pathophysiological condition related to diabetes and obesity .
RS could reduce blood glucose and ameliorate IR in animals , but its effect in human population is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of RS diet supplement on ameliorating IR in patients with T2DM and simple obesity .
Resistant starch lowers postprandial glucose and leptin in overweight adults consuming a moderate-to-high-fat diet: a randomized-controlled trial
Background High-amylose maize resistant starch type 2 ( HAM-RS2 ) stimulates gut-derived satiety peptides and reduces adiposity in animals . Human studies have not supported these findings despite improvements in glucose homeostasis and insulin sensitivity after HAM-RS2 intake which can lower adiposity-related disease risk . The primary objective of this study was to evaluate the impact of HAM-RS2 consumption on blood glucose homeostasis in overweight , healthy adults . We also examined changes in biomarkers of satiety ( glucagon-like peptide-1 [ GLP-1 ] , peptide YY [ PYY ] , and leptin ) and body composition determined by anthropometrics and dual-energy x-ray absorptiometry , dietary intake , and subjective satiety measured by a visual analogue scale following HAM-RS2 consumption . Methods Using a r and omized-controlled , parallel-arm , double-blind design , 18 overweight , healthy adults consumed either muffins enriched with 30 g HAM-RS2 ( n = 11 ) or 0 g HAM-RS2 ( control ; n = 7 ) daily for 6 weeks . The HAM-RS2 and control muffins were similar in total calories and available carbohydrate . Results At baseline , total PYY concentrations were significantly higher 120 min following the consumption of study muffins in the HAM-RS2 group than control group ( P = 0.043 ) . Within the HAM-RS2 group , the area under the curve ( AUC ) glucose ( P = 0.028 ) , AUC leptin ( P = 0.022 ) , and postpr and ial 120-min leptin ( P = 0.028 ) decreased independent of changes in body composition or overall energy intake at the end of 6 weeks . Fasting total PYY increased ( P = 0.033 ) in the HAM-RS2 group , but changes in insulin or total GLP-1 were not observed . Mean overall change in subjective satiety score did not correlate with mean AUC biomarker changes suggesting the satiety peptides did not elicit a satiation response or change in overall total caloric intake . The metabolic response from HAM-RS2 occurred despite the habitual intake of a moderate-to-high-fat diet ( mean range 34.5 % to 39.4 % of total calories ) . Conclusion Consuming 30 g HAM-RS2 daily for 6 weeks can improve glucose homeostasis , lower leptin concentrations , and increase fasting PYY in healthy overweight adults without impacting body composition and may aid in the prevention of chronic disease . However , between-group differences in biomarkers were not observed and future research is warranted before specific recommendations can be made . Trial registration None
The results indicated that there was no significant difference in the amelioration of BMI , HOMA-%S and HOMA-%B in T2DM patients between RS and the non-RS supplementation .
There was no significant difference between RS and non-RS supplements in patients with simple obesity .
Conclusion RS supplementation can ameliorate IR in T2DM , especially for the patients of T2DM with obesity , but not in simple obesity
Background Resistant starch ( RS ) is a starch that can be fermented by the microbial flora within gut lumen .
Insulin resistance ( IR ) is a pathophysiological condition related to diabetes and obesity .
RS could reduce blood glucose and ameliorate IR in animals , but its effect in human population is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of RS diet supplement on ameliorating IR in patients with T2DM and simple obesity .