There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Oxidative stress in preterm infants fed a formula containing long-chain polyunsaturated fatty acids (LCPUFA).
Our study examined if dietary long-chain polyunsaturated fatty acids ( LCPUFA ) have an impact on oxidative stress in preterm infants .  Serum malonyldialdehyde ( MDA ) , total peroxide concentrations , and total antioxidant capacity were determined at mean ( st and ard deviation [ SD ] ) 34.7 ( 10.9 ) days of life in 104 healthy preterm infants ( gestational age , 32.6 [ 2.9 ] weeks ; birthweight ; 1605 [ 285 ] g ) who were r and omly assigned to be fed since birth either a formula containing LCPUFA ( arachidonic and docosahexaenoic ) ( group A , n = 50 ) or a LCPUFA-free formula with identical compositions for other nutrients ( group B , n = 54 ) . Clinical and anthropometric characteristics did not differ significantly between the two groups . Mean ( SD ) serum MDA levels did not differ significantly between groups A ( 0.23 [ 0.04 ] micromol/L ) and B ( 0.22 [ 0.05 ] micromol/L ) . The concentrations of total peroxides were below the detection limits of the assay in 41 of 50 ( 82 % ) infants of group A and 43 of 54 ( 79 % ) infants of group B and not significantly different between the two infant groups . No difference was observed in serum total antioxidant capacity between groups A ( 340.0 [ 46.2 ] micromol/L ) and B ( 354.7 [ 46.5 ] micromol/L ) . We concluded that supplementation of infant formulas with LCPUFA does not affect lipid peroxidation in healthy preterm infants
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .