Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .
Transdermal electromotive multi-drug administration for Peyronie's disease: preliminary results.
The purpose of this study was to clarify the actual therapeutic potential of a new transdermal drug delivery system ( electromotive drug administration ; EMDA ) for selected patients with Peyronie 's disease . Forty patients with Peyronie 's disease were treated by electromotive administration of the 3-drug association orgotein-dexamethasone-lidocaine in a double-blind , placebo-controlled , partial crossover study ( study 1 ) . Another 25 patients were treated by EMDA with a combination of verapamil-dexamethasone in an uncontrolled study ( study 2 ) . Treatment sessions lasted 20 minutes each and took place 3 times a week for 3 weeks with a current of 3 mA. Patients were assessed before treatment and at 1- and 3-month follow-up examinations . Assessment s were based on sexual history , physical examination , and dynamic color Doppler ultrasonographic results . Adverse effects of EMDA were not reported . In study 1 , the clinical results observed after treatment proved to be significantly better than those of the placebo .  Penile pain disappeared in all patients in both studies . Penile lesion ( nodule or plaque ) either disappeared or significantly improved in 79 % and 90 % of patients treated by the 3- and 2-drug association , respectively . The improvement of penile deformity also was notable although it did not match the effect observed on penile nodules or plaque ( 62 % and 88 % , in studies 1 and 2 , respectively ) . In both studies , more than 80 % of patients reported a definite amelioration of penile rigidity , which paralleled the improvement of penile dynamic color Doppler ultrasonographic parameters . Overall , the combination of verapamil-dexamethasone achieved better clinical results than the 3-drug combination . Electromotive drug administration is a novel technique capable of safely achieving satisfactory results in selected patients with Peyronie 's disease not only in terms of improvement of patient 's symptoms but also due to the reduced need for penile surgery
Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .