It is not possible to draw any firm conclusions about the use of topiramate in clinical practice from this evidence .
BACKGROUND Bipolar disorder is a common recurrent illness with high levels of chronicity .
Previous trials have suggested that the anticonvulsant topiramate may be efficacious in bipolar disorder .
This is an up date of a previous Cochrane review ( last published 2006 ) on the role of topiramate in bipolar disorder .
OBJECTIVES To assess the effects of topiramate for acute mood episodes  in bipolar disorder in adults compared to placebo , alternative pharmacological treatment , and combination pharmacological treatment as measured by treatment of symptoms on specific rating scales for individual episodes .
Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania
Objective : The purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania . Methods : In this study which was a double-blinded r and omized clinical trial , 46 bipolar patients in manic episode , were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by Young Mania Rating Scale ( YMRS ) weekly . Results : In both intervention and control groups , YMRS score had significant decline after 8 weeks(p < 0.001 ) , but there was no statistically significant difference between the two groups ( p = 0.419 ) . The highest score decline was after two weeks . YMRS score at baseline did not have statistically significant difference between the intervention and control groups ( p = 0.709 ) . Conclusions : This study failed to show antimanic efficacy of adjunctive topiramate in the treatment of those with acute manic . Declaration of interest : None . Clinical Trial Registration : URL : http://www.i rct .ir . I RCT 201110317960N1
It is not possible to draw any firm conclusions about the use of topiramate in clinical practice from this evidence .
BACKGROUND Bipolar disorder is a common recurrent illness with high levels of chronicity .
Previous trials have suggested that the anticonvulsant topiramate may be efficacious in bipolar disorder .
This is an up date of a previous Cochrane review ( last published 2006 ) on the role of topiramate in bipolar disorder .
OBJECTIVES To assess the effects of topiramate for acute mood episodes  in bipolar disorder in adults compared to placebo , alternative pharmacological treatment , and combination pharmacological treatment as measured by treatment of symptoms on specific rating scales for individual episodes .