Conclusions : In summary , the use of ITF may have benefits for LDL-c reduction across all study population s , whereas HDL-c improvement and glucose control were demonstrated only in the T2DM subgroup .
Overall , ITF supplementation may provide a novel direction for improving the lipid profile and glucose metabolism
Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects
Objective : To study the effect of the intake of 15 g nondigestible oligosaccharides per day on various parameters of large-bowel function , as well as on  blood lipid concentrations  and glucose absorption in man . Design : Latin square , r and omized , double-blind , diet-controlled . Setting : Metabolic research unit . Subjects : Twelve apparently healthy men ( mean age 23 years ) , recruited from the Institute ’s pool of volunteers , no drop-outs . Interventions : Four treatment periods of 3 weeks : inulin , fructo-oligosaccharides ( FOS ) , galacto-oligosaccharides ( GOS ) and control ; analyses of stool weight , intestinal transit , faecal pH , short-chain fatty acids , bile acids , faecal enzymes , blood lipids and glucose absorption . Results : As compared to the control treatment : higher concentration of faecal acetate ( inulin and GOS , P<0.05 ) and valerate ( inulin , P<0.05 ) , significantly lower concentration of faecal deoxycholic acid ( inulin and FOS , P<0.05 and P<0.02 , respectively ) and β-glucuronidase activity ( inulin and GOS , P<0.05 and P<0.02 respectively ) . Other changes of faecal parameters and those of blood lipids and glucose absorption were statistically not significant . Conclusions : Results indicate that nondigestible oligosaccharides are ( partly ) fermented in the human colon , but in healthy young men the effects are limited . Also the consumption of 15 g nondigestible oligosaccharides does not seem to alter blood lipid concentrations and glucose absorption in our young healthy adults . Sponsorship : European Union and ORAFTI s.a . , Tienen , Belgium
Conclusions : In summary , the use of ITF may have benefits for LDL-c reduction across all study population s , whereas HDL-c improvement and glucose control were demonstrated only in the T2DM subgroup .
Overall , ITF supplementation may provide a novel direction for improving the lipid profile and glucose metabolism