Results : Duloxetine may be an effective treatment for mood spectrum disorders , panic disorder , several symptom clusters of borderline personality , and as add-on drug in schizophrenia .
Modest or conflicting results have been found for the efficacy of duloxetine in obsessive-compulsive disorder , posttraumatic stress disorder , eating , and sexual disorders .
Background : Duloxetine hydrochloride ( DUL ) is an antidepressant included in the pharmacological class of serotonin-norepinephrine reuptake inhibitors approved for the treatment of major depressive disorder , generalized anxiety disorder , diabetic peripheral neuropathic pain , fibromyalgia , and chronic musculoskeletal pain .
The aim of this review was to eluci date current evidence s on the use of DUL in the treatment of a variety of psychiatric disorders .
What is an open label trial?
Research ers assessed the effectiveness of prazosin combined with scorpion antivenom in assisting recovery from scorpion sting . An open label r and omised controlled trial study design was used . The control treatment was prazosin alone . The setting was a hospital and research centre in Mahad , a region of India . Participants were patients with grade 2 scorpion envenomation , older than 6 months , and with no cardiorespiratory or central nervous system abnormalities . In total , 70 patients were recruited and allocated to treatment ( 35 to prazosin and scorpion antivenom , and 35 to prazosin alone ) by block r and omisation.1 The primary endpoint was resolution of the clinical syndrome within 10 hours of treatment , as assessed by the research ers . The secondary endpoints included the time needed for complete resolution of the clinical syndrome . The proportion of patients who showed complete resolution of the clinical syndrome within 10 hours of treatment was significantly greater in the prazosin plus antivenom group than in the prazosin alone group ( 91.4 % v 22.9 % ; difference 68.5 % , 95 % confidence interval 51.8 % to 85.2 % ; P<0.001 ) . The mean time needed for complete resolution of the clinical syndrome was significantly shorter in the antivenom plus prazosin group ( 8 v 17.7 h ; difference −9.7 h , −6.9 to −12.4 ) ; P<0.001 ) . The research ers concluded that recovery from a scorpion sting was hastened by simultaneous administration of scorpion antivenom plus prazosin compared with prazosin alone . Which of the following statements , if any , are true
Results : Duloxetine may be an effective treatment for mood spectrum disorders , panic disorder , several symptom clusters of borderline personality , and as add-on drug in schizophrenia .
Modest or conflicting results have been found for the efficacy of duloxetine in obsessive-compulsive disorder , posttraumatic stress disorder , eating , and sexual disorders .
Background : Duloxetine hydrochloride ( DUL ) is an antidepressant included in the pharmacological class of serotonin-norepinephrine reuptake inhibitors approved for the treatment of major depressive disorder , generalized anxiety disorder , diabetic peripheral neuropathic pain , fibromyalgia , and chronic musculoskeletal pain .
The aim of this review was to eluci date current evidence s on the use of DUL in the treatment of a variety of psychiatric disorders .