There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
The Infant Fish Oil Supplementation Study (IFOS): design and research protocol of a double-blind, randomised controlled n--3 LCPUFA intervention trial in term infants.
STUDY DESIGN The Infant Fish Oil Supplementation Study is a double-blind r and omised controlled trial investigating whether the incidence of allergic disease can be reduced and developmental outcomes enhanced through supplementation with omega-3 fatty acids .  Infants at high risk of developing allergic disease will be r and omised to receive either fish oil or olive oil supplements until 6 months of age and followed up at six postnatal clinic visits to assess allergy outcomes and infant neurodevelopment . INTERVENTION Study groups to consist of a treatment group allocated to receive 650 mg of fish oil daily ( 250 - 280 mg docosahexaenoic acid and at least 60 mg eicosapentaenoic acid and a placebo group ( olive oil ) from birth to 6 months of age . OUTCOMES Allergy outcomes will be assessed by clinical history , clinical assessment s and allergen skin prick tests at the 12 , 30 and 60 month visits . Neurodevelopmental assessment s to be conducted at 18 months , and language question naires at 12 , 18 and 30 months . Sample s will be collected from mothers antenatally , from infants at birth , and at clinic visits from 6 months onwards for immunological assessment s. Fatty acid composition to be measured in erythrocytes and plasma ( at birth and after the supplementation period ) to assess the effect of the intervention on fatty acid status . Information on medical history , diet and other lifestyle factors at an antenatal clinic visit and postnatal clinic visits will also be collected . CONCLUSION This study is design ed to examine clinical ly relevant effects of a novel , non-invasive and potentially low cost approach to reduce the incidence of allergic disease and facilitate neurodevelopment during early childhood
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .