Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Statins as immunomodulators in systemic sclerosis.
Systemic sclerosis ( SSc ) has the highest case-specific mortality among the rheumatic diseases . Vascular dysfunction and structural wall abnormalities are among the earliest and fundamental alterations in SSc . Statins have a number of immunomodulating effects on vascular wall cells , which may modify the progression of vascular injury . The aim of this study was to evaluate the potential efficacy of statin therapy in ameliorating endothelial dysfunction ( ED ) in SSc by investigating the effect of statins on some markers that reflect endothelial activation in SSc . Forty patients with SSc were r and omized into two groups to receive 6 months ' treatment with atorvastatin ( n = 20 ; dose , 40 mg/day ) or placebo ( n = 20 ) as an adjuvant to existing therapy . Markers of ED including ET-1 , plasma nitrate levels , and thrombomodulin ( TM ) were evaluated by the enzyme-linked immunosorbent assay ( ELISA ) technique . Fibrinogen , high-sensitivity C-reactive protein ( hsCRP ) , ESR , lipid peroxide ( LP ) , and malonylaldehyde ( MDA ) levels were also assessed . Brachial flow-mediated vasodilatation was assessed by ultrasonography . Patients were studied at base line and after 6 months of statin therapy . After 6 months of therapy , ET-1 , ICAM-1 , sE-selectin , vWF , fibrinogen , ESR , hsCRP as well as LP and MDA levels declined and NO increased significantly in the statin-treated SSc group when compared to the placebo-treated group . Endothelium-dependent vasodilatation ( EDV ) improved significantly in the atorvastatin-treated group . The findings of this study demonstrated statin-mediated improvements in the endothelial function of SSc patients as well as immunomodulating effects . Statins may thus prove to be an invaluable addition to the therapy of the vasculopathy of SSc
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .