We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
Nitrogen utilization and bone mineralization in very low birth weight infants fed partially hydrolyzed preterm formula.
Partialy hydrolyzed formulas have been proposed for term and preterm infants , but decreased nitrogen and calcium intestinal absorption rates , together with plasma amino acid imbalances have been reported in preterm infants . We evaluated a new formula with modified nitrogen and calcium sources ( glycerophosphate ) . During their second week of life , 16 preterm infants were r and omly assigned to 1 of 2 groups : 9 were fed the new partially hydrolyzed formula  and 7 a  conventional formula . A nutrient balance was performed at the end of the first month of life . Amino acid concentrations and whole-body mineralization were measured at the end of study period ( theoretical term ) .  Birth weight and gestational age ( mean + /- SD ) were similar in the 2 groups ( 28.9 + /- 7.0 wks and 1,183 + /- 242 g v 27.7 + /- 1.0 wks and 1,139 + /- 162 g ) . Median nitrogen absorption rate ( 85 % v 89 % ; P = .03 ) was lower in infants fed the new formula than in those fed the conventional one . After correction for difference in nitrogen intake , there was no significant difference in N retained between the 2 groups ( P = .11 ) . Plasma amino acid concentrations were also similar in the 2 groups . At theoretical term , median bone mineral content was not significantly different between the 2 groups ( 50 g/kg v 55 g/kg ; P = .17 ) and it was close to the reference values obtained in term neonates just after birth . As long as nitrogen content is 10 % higher in protein hydrolyzed formula than in entire protein formula , appropriate nitrogen retention , plasma amino acid profile can be achieved with the new partially hydrolyzed formula . In both groups , bone mineralization at theoretical term was close to the mineralization observed term neonates just after birth
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .