LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Nonutilization of Statins in a Community-based Population with a History of Coronary Revascularization.
PURPOSE Statin therapy has been reported to reduce the incidence of vascular events in patients with atherosclerosis , but adherence to statins may be suboptimal . The aims of this study were to quantify the rate of  statin  use among individuals with a history of coronary revascularization in a large , integrated health care system and to determine which demographic characteristics and clinical factors are associated with statin use . METHODS This was a retrospective cohort study using data base programming and chart review . The study included adult members of Kaiser Permanente Northern California with a history of coronary revascularization . The study outcome was off-statin status , defined as a ≥1-year gap between filled prescriptions . The predictor variables included age , race , body mass index , dyslipidemia , liver disease , kidney disease , and history of statin allergy . Multivariable logistic regression was used to quantify the associations between the predictor variables and statin status . A chart review of a r and omly selected subset was performed to identify reasons why individuals were not taking statins . FINDINGS The study population included 17,869 Kaiser Permanente Northern California members , of which 18.3 % had off-statin status . The following variables were associated with off-statin status : statin allergy ( odds ratio [ OR ] = 2.18 ; 95 % CI , 1.89 - 2.52 ) , end-stage renal disease ( OR = 1.55 ; 95 % CI , 1.26 - 1.91 ) , liver disease ( OR = 1.44 ; 95 % CI , 1.08 - 1.93 ) , African-American race ( OR = 1.55 vs white ; 95 % CI , 1.32 - 1.81 ) , and Latino race ( OR = 1.18 ; 95 % CI , 1.05 - 1.33 ) . The chart review found that off-statin status typically reflects patient ( 79 % ) rather than provider ( 21 % ) preference . IMPLICATION S A significant minority of patients with a history of coronary revascularization are not taking statins . Off-statin status is associated with kidney disease , liver disease , African-American race , and Latino race . At an individual level , off-statin status was usually driven by patient preference , due to minor or undefined reasons . These findings may be useful in guiding strategies to increase statin use in individuals with atherosclerosis
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .