There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Lipoprotein-cholesterol responses in healthy infants fed defined diets from ages 1 to 12 months: comparison of diets predominant in oleic acid versus linoleic acid, with parallel observations in infants fed a human milk-based diet.
A prospect i ve study in healthy infants predefining both diet fatty acid and cholesterol , from birth to age 1 year , compared response of cholesterol fractions in three groups : r and om assignment to 1 ) monounsaturated-(Hi-Mono ) ( n = 20 ) , or 2 ) polyunsaturated-(Hi-Poly ) ( n = 22 ) fatty acid-enriched diets , or 3 ) non-r and omized selection to breast feeding ( Human Milk ) ( n = 25 ) .  In each group , design ated weaning foods and supplements maintained fatty acid and cholesterol intake similar to that of each group 's defined formulas , with long-term compliance confirmed by plasma phospholipid fatty acid concentrations . By 12 months , total cholesterol was significantly lower in the Hi-Poly group compared to either of the other groups ( P < 0.05 ) . Low density lipoprotein (LDL)- and high density lipoprotein (HDL)-cholesterol concentrations were significantly lower by 12 months in the Hi-Poly group , compared to the Hi-Mono groups . However , at the earlier 4-month interval , total cholesterol and LDL-cholesterol in both Hi-Mono and Hi-Poly groups were not different from each other , although each was significantly lower than the parallel Human Milk-group ( P < 0.05 ) . The Hi-Mono group increased gradually in total and LDL-cholesterol such that , after 12 months ' feedings , all lipid fractions of this Hi-Mono group were no different from those of the Human Milk group . In independent group comparisons , there were no significant differences in HDL-cholesterol concentrations after 4 and 9 months on these diets . Independent of diet , HDL-cholesterol showed a falling trend as an overall time-effect across all groups ( P < 0.001 ) . These data suggest that prolonged feeding of a diet enriched in polyunsaturated acids in early infancy has a significant cholesterol-lowering effect compared to monounsaturates . These differences in total , LDL- , and HDL-cholesterol plasma concentrations between polyunsaturates and monounsaturates were not significantly evident until feedings had continued for a year
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .