The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Treatment of hypertension in the elderly: effects on blood pressure, heart rate, and physical fitness.
The subjects were 36 hypertensive patients aged 61 to 79 years ( mean , 66 years ) . After a placebo run-in period of one month , each patient was r and omly assigned to two months of treatment with 100 mg of metoprolol , 50 mg of captopril , or 25 mg of hydrochlorothiazide plus 2.5 mg of amiloride daily , or placebo . The doses were doubled if diastolic pressure was above 95 mm Hg after one month of treatment . Blood pressure , heart rate , and physical fitness ( endurance during a st and ard cycle ergometer exercise ) were measured and side effects assessed after each two-month treatment period . Mean blood pressures were significantly lower after treatment with metoprolol ( 154/92 mm Hg ) , captopril ( 157/92 mm Hg ) , and hydrochlorothiazide-amiloride ( 152/91 mm Hg ) than after placebo ( 170/101 mm Hg ) . Heart rate was significantly lower after treatment with metoprolol ( 64 beats/minute ) than after placebo ( 77 beats/minute ) . Exercise endurance was lower after treatment with metoprolol ( 498 seconds ) and hydrochlorothiazide-amiloride ( 519 seconds ) than after placebo ( 529 seconds ) and higher after captopril ( 541 seconds ) . More patients reached the target exercise work load after captopril than after the other treatments . No patients withdrew from treatment because of side effects or abnormal laboratory test results . All three active treatments benefited the elderly hypertensive patients and did not lower their physical fitness .  Captopril appeared to be more effective than the other two treatments
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .