There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .
EPIBACDIAL: a multicenter prospective study of risk factors for bacteremia in chronic hemodialysis patients.
Bacteremic infections are a major cause of mortality and morbidity in chronic hemodialysis patients . New developments in managing these patients ( erythropoietin therapy , nasal mupirocin , long-term implanted catheters , and synthetic membranes ) may have altered the epidemiologic patterns of bacteremia in dialysis patients . This multicenter prospect i ve cross-sectional study was carried out to determine the current incidence of and risk factors for bacteremia in chronic hemodialysis patients in France . A total of 988 adults on chronic hemodialysis for 1 mo or longer was followed up prospect ively for 6 mo in 19 French dialysis units . The factors associated with the development of at least one bacteremic episode over 6 mo were determined using the multivariate Cox proportional hazards model . Staphylococcus aureus ( n=20 ) and coagulase-negative staphylococci ( n=15 ) were responsible for most of the 51 bacteremic episodes recorded . The incidence of bacteremia was 0.93 episode per 100 patient-months . Four risk factors for bacteremia were identified : ( 1 ) vascular access ( catheter versus fistula : RR=7.6 ; 95 % CI , 3.7 to 15.6 ) ; ( 2 ) history of bacteremia ( > or = 2 versus no previous episode : RR=7.3 ; 95 % CI , 3.2 to 16.4 ) ; ( 3 ) immunosuppressive therapy ( current versus no : RR=3.0 ; 95 % CI , 1.0 to 6.1 ) ; and ( 4 ) corpuscular hemoglobin ( per 1 g/dl increment : RR=0.7 ; 95 % CI , 0.6 to 0.9 ) . Catheters , especially long-term implanted catheters , were found to be the leading risk factor of bacteremia in chronic hemodialysis patients . There was a trend toward recurrence of bacteremia that was not associated with chronic staphylococcal nasal carriage . Synthetic membranes were not associated with a lower risk of bacteremia in this population of well dialyzed patients , but anemia linked to resistance to erythropoietin appeared to be a possible risk factor for bacteremia
There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .