These findings were robust in sensitivity analyses .
Conclusions This meta- analysis suggests that Mg supplementation significantly reduces serum CRP level .
Introduction The aim of the study was to undertake a systematic review and meta- analysis of prospect i ve studies to determine the effect of magnesium ( Mg ) supplementation on  C-reactive protein ( CRP ) .
No positive effect of oral magnesium supplementation in the decreases of inflammation in subjects with prediabetes: a pilot study.
To determine whether oral magnesium supplementation modifies serum levels of high-sensitivity C-reactive protein ( hsCRP ) , TNF-alpha , IL-6 , and IL-10 in subjects with prediabetes , inflammation , and hypomagnesemia , a total of 26 subjects men and non-pregnant women were included and r and omly allocated to receive 30 ml of MgCl(2 ) 5 % solution ( equivalent to 382 mg of magnesium ) or placebo , daily during three months . At baseline conditions , there were not significant statistical differences between the groups . At end of the study , hsCRP levels were significantly lower in the intervention group ( 3.3 ± 2.5 vs 8.0 ± 5.9 mg/L , p = 0.03 ) , as compared with the control group . However , the intra-group analysis of the individuals who received magnesium , did not shows significant statistical differences between baseline and final conditions ( 4.1 ± 3.0 and 3.3 ± 2.5 , p = 0.45 ) . In addition , TNF-alpha ( 1.2 ± 0.3 vs 1.1 ± 0.3 pg/mL , p = 0.69 ) , IL-6 ( 0.3 ± 0.3 vs 5.0 ± 7.7 pg/mL , p = 0.08 ) , and IL-10 ( 1.8 ± 0.4 vs 1.8 ± 0.5 pg/mL , p = 0.89 ) serum levels were not significantly different between the groups . Our results do not show a beneficial effect  of oral magnesium supplementation on hsCRP , IL-6 , TNF-alpha , and IL-10 levels in prediabetic subjects with hypomagnesemia and inflammation . Further studies with large sample sizes and longer time of follow-up are necessaries to verify the results of our pilot study
These findings were robust in sensitivity analyses .
Conclusions This meta- analysis suggests that Mg supplementation significantly reduces serum CRP level .
Introduction The aim of the study was to undertake a systematic review and meta- analysis of prospect i ve studies to determine the effect of magnesium ( Mg ) supplementation on  C-reactive protein ( CRP ) .