Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .
Conjugated linoleic acid reduces body fat mass in overweight and obese humans.
Conjugated linoleic acid ( CLA ) has been shown to reduce body fat mass ( BFM ) in animals . To investigate the dose-response relationships of conjugated linoleic acid with regard to BFM in humans , a r and omized , double-blind study including 60 overweight or obese volunteers ( body mass index 25 - 35 kg/m(2 ) ) was performed . The subjects were divided into five groups receiving placebo ( 9 g olive oil ) , 1.7 , 3.4 , 5.1 or 6.8 g conjugated linoleic acid per day for 12 wk , respectively . Dual-energy X-ray absorptiometry was used to measure body composition [ measurements at wk 0 ( baseline ) , 6 and 12 ] . Of the 60 subjects , 47 completed the study . Eight subjects withdrew from the study due to adverse events ; however , no differences among treatment groups were found regarding adverse events . Repeated- measures analysis showed that a significantly higher reduction in BFM was found in the conjugated linoleic acid groups compared with the placebo group ( P : = 0.03 ) . The reduction of body fat within the groups was significant for the 3.4 and 6.8 g CLA groups ( P : = 0.05 and P : = 0.02 , respectively ) . No significant differences among the groups were observed in lean body mass , body mass index , blood safety variables or blood lipids . The data suggest that conjugated linoleic acid may reduce BFM in humans and that no additional effect on BFM is achieved with doses > 3.4 g CLA/d
Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .