There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Growth and development in term infants fed long-chain polyunsaturated fatty acids: a double-masked, randomized, parallel, prospective, multivariate study.
OBJECTIVE To evaluate the effects of dietary intake of the long-chain polyunsaturated fatty acids , arachidonic acid ( AA ) , and docosahexaenoic acid ( DHA ) on multiple indices of infant growth and development . DESIGN A double-masked , r and omized , parallel trial was conducted with term infants fed formulas with or without AA+DHA for 1 year ( N = 239 ) . Reference groups of breastfed infants ( N = 165 ) weaned to formulas with and without AA+DHA  were also studied . Infants in the formula groups were r and omized at < /=9 days of age to a control formula with no AA or DHA ( n = 77 ) or 1 of 2 otherwise identical formulas containing AA+DHA ( AA , 0.46 % and DHA , 0.14 % of total fatty acids ) from either egg-derived triglyceride ( egg-DTG [ n=80 ] ) or fish oil and fungal oil ( fish/fungal [ n = 82 ] ) at levels similar to the average in breast milk sample s as measured in the reference group . All formulas contained 50 % of energy from fat with the essential dietary fatty acids , linoleic acid ( 20 % fatty acids ) and alpha-linolenic acid ( 2 % fatty acids ) . The main study outcomes were AA and DHA levels in plasma and red blood cells , and multiple measures of infant development at multiple ages from birth to 14 months : growth , visual acuity , information processing , general development , language , and temperament . RESULTS  AA and DHA levels in plasma and red cells were higher in AA+DHA-supplemented groups than in the control formula group and comparable to those in reference groups . No developmental test results distinguished these groups . Expected differences in family demographics associated with breastfeeding were found , but no advantages to breastfeeding on any of the developmental outcome demonstrated . CONCLUSIONS These findings do not support adding AA+DHA to formulas containing 10 % energy as linoleic acid and 1 % energy as alpha-linolenic acid to enhance growth , visual acuity , information processing , general development , language , or temperament in healthy , term infants during the first 14 months after birth.infant development , breast feeding , infant formula , long-chain polyunsaturated fatty acids , docosahexaenoic acid
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .