Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform
Caffeine acutely increases blood pressure and peripheral vascular resistance , in part because of sympathetic stimulation . Its effects on large artery properties are largely unknown . In a double-blind crossover study , 7 healthy subjects 26±2.6 years of age ( mean±SEM ) were studied for 90 minutes while in the supine position on 2 occasions separated by a week in r and om order after ingestion of 250 mL caffeinated ( 150 mg ) and decaffeinated ( < 2 mg ) coffee . Compared with baseline , arterial stiffness measured by carotid femoral pulse wave velocity increased progressively from 7.2±0.41 to 8.0±0.6 m/s ( P < 0.05 ) at 90 minutes after caffeine intake , an effect that may be independent of changes in blood pressure . In addition , arterial wave reflection , measured by applanation tonometry from the aortic pressure waveform , also increased from −5.7±7.6 % to 5.28%±5.6 ( P < 0.01 ) . No such changes were seen with decaffeinated coffee intake . Although the integral of the brachial systolic and diastolic blood pressure values over the 90 minutes was larger ( P < 0.05 ) after caffeinated than decaffeinated coffee intake , the effect on aortic systolic and diastolic blood pressures was more pronounced ( P < 0.05 ) than on the brachial artery . These results show a significant effect of caffeine intake on arterial tone and function and suggest that caffeine acutely increases arterial stiffness
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .