Combination therapy studies of third-line treatments were rare and centered on medication with PTNS .
Combination therapy , with certain first , second , and third-line OAB therapies , appears to be efficacious .
AIMS Overactive bladder ( OAB ) affects over 17 % of the population and significantly effect the health-related quality of life .
The treatments for OAB include first line ( lifestyle modification , pelvic floor muscle training ) , second line ( anticholinergic or beta-3 agonist medications ) , and third line therapies ( intradetrusor botulinum toxin injection , sacral neurostimulation [ SNM ] , or percutaneous tibial nerve stimulation [ PTNS ] ) .
For those with urinary incontinence secondary to OAB , complete continence is the goal of therapy , though cure rates are only 5 % to 40 % .
The use of combination therapies can be employed in refractory OAB , however , the efficacy of pooled modalities is relatively unknown .
Our objective was to determine the volume of data supporting combination therapy in treating OAB .
Bladder Training versus Combination of Propiverine with Bladder Training for Female Urinary Frequency
Objective : Among lower urinary tract symptoms , urinary frequency is one of the prevalent symptoms in the female population . The objective of this study was to evaluate the effect of bladder training with or without pharmacotherapy in women with only a frequency symptom . Methods : Patients were r and omized to either bladder training alone ( n = 23 ) or propiverine combined with bladder training ( n = 25 ) . All patients were treated during 3 months . Results : At baseline , daytime frequency was higher in the combination therapy group than in the bladder training group ( p = 0.031 ) . No difference in other characteristics was observed in the two groups . After treatment , there was no significant difference of functional bladder capacity and average voided volume between the two groups but daytime frequency was higher in the combination therapy group than in the bladder training group ( p = 0.013 ) . However , the changes of daytime frequency , functional bladder capacity and average voided volume were not significantly different in the groups . Of total patients , 15 ( 65.2 % ) in the bladder training group and 21 ( 84.0 % ) in the combination therapy group were rated as responders ( defined as improved or much improved ) ( p = 0.133 ) . Conclusions : Both bladder training with or without pharmacotherapy may improve the subjective and objec- tive frequency symptom in women with only a frequency symptom . However , we could not find that there was more symptomatic improvement when anticholinergics combined with bladder training were compared with bladder training alone
Combination therapy studies of third-line treatments were rare and centered on medication with PTNS .
Combination therapy , with certain first , second , and third-line OAB therapies , appears to be efficacious .
AIMS Overactive bladder ( OAB ) affects over 17 % of the population and significantly effect the health-related quality of life .
The treatments for OAB include first line ( lifestyle modification , pelvic floor muscle training ) , second line ( anticholinergic or beta-3 agonist medications ) , and third line therapies ( intradetrusor botulinum toxin injection , sacral neurostimulation [ SNM ] , or percutaneous tibial nerve stimulation [ PTNS ] ) .
For those with urinary incontinence secondary to OAB , complete continence is the goal of therapy , though cure rates are only 5 % to 40 % .
The use of combination therapies can be employed in refractory OAB , however , the efficacy of pooled modalities is relatively unknown .
Our objective was to determine the volume of data supporting combination therapy in treating OAB .