RESULTS For the comparison of statins ( + /- sildenafil ) with placebo ( + /- sildenafil ) , the mean International Index of Erectile Function ( IIEF-5 ) ( the st and ardized mean difference [ SMD ] = 3.23 , 95 % confidence interval [ CI ] = -1.65 to 4.80 , P < 0.0001 ) indicated that statins ( + /- sildenafil ) showed statistically significantly greater improvements in the mean IIEF-5 compared with placebo ( + /- sildenafil ) .
For the comparison of statins plus sildenafil with placebo plus sildenafil , the mean IIEF-5 ( SMD = 3.60 , 95 % CI = 2.64 to 4.56 , P < 0.00001 ) , the IIEF domain ( SMD = 4.88 , 95%CI = 3.01 to 6.74 , P < 0.00001 ) , and the global efficacy question ( odds ratio = 6.44 , 95 % CI = 2.92 to 14.23 , P < 0.00001 ) showed that compared with placebo plus sildenafil , statins plus sildenafil clearly improved erectile function .
CONCLUSIONS This meta- analysis indicates that statins ( + /- sildenafil ) may improve ED compared with placebo ( + /- sildenafil )
INTRODUCTION It is not known if statins will improve symptoms in patients with established erectile dysfunction ( ED ) .
AIM We carried out a systematic review and meta- analysis to assess the effect of statins on ED .
The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
Phosphodiesterase-5 ( PDE-5 ) inhibitors are an effective therapy for the majority of men with erectile dysfunction ( ED ) . However , many men with ED still report a suboptimal or partial response even after an adequate trial of oral PDE-5 therapy . Since ED is associated with impaired vascular function and both atorvastatin and quinapril have been previously shown to improve vascular function , we examined the effects of adjunctive treatment with these medications in men with vasculogenic ED who were suboptimal responders to 100 mg of sildenafil . Men with ED and suboptimal response to sildenafil  were r and omly assigned to 3 months of treatment with atorvastatin 40 mg ( n = 12 ) , quinapril 10 mg ( n = 10 ) , or placebo ( n = 13 ) , along with continued adjunctive sildenafil use . Measured variables included : International Index of Erectile Function ( IIEF ) question naire , brachial artery flow-mediated dilation ( FMD ) , endothelium-independent dilation ( EID ) via nitroglycerin , penile Doppler blood flow , blood pressure ( BP ) , lipids , and C-reactive protein ( CRP ) . Compared to placebo , quinapril ( p < 0.01 ) significantly improved symptoms of ED as measured by the IIEF-5 question naire . There was a trend toward a significant improvement in IIEF-5 with atorvastatin . Similarly , quinapril significantly improved the IIEF ED Domain ( p < 0.05 ) . Other peripheral and penile vascular parameters were unchanged with drug therapy as compared to placebo . In conclusion , treatment with quinapril , in combination with sildenafil , improved ED in men with suboptimal response to sildenafil alone . Atorvastatin demonstrated a trend toward improved ED in this group
RESULTS For the comparison of statins ( + /- sildenafil ) with placebo ( + /- sildenafil ) , the mean International Index of Erectile Function ( IIEF-5 ) ( the st and ardized mean difference [ SMD ] = 3.23 , 95 % confidence interval [ CI ] = -1.65 to 4.80 , P < 0.0001 ) indicated that statins ( + /- sildenafil ) showed statistically significantly greater improvements in the mean IIEF-5 compared with placebo ( + /- sildenafil ) .
For the comparison of statins plus sildenafil with placebo plus sildenafil , the mean IIEF-5 ( SMD = 3.60 , 95 % CI = 2.64 to 4.56 , P < 0.00001 ) , the IIEF domain ( SMD = 4.88 , 95%CI = 3.01 to 6.74 , P < 0.00001 ) , and the global efficacy question ( odds ratio = 6.44 , 95 % CI = 2.92 to 14.23 , P < 0.00001 ) showed that compared with placebo plus sildenafil , statins plus sildenafil clearly improved erectile function .
CONCLUSIONS This meta- analysis indicates that statins ( + /- sildenafil ) may improve ED compared with placebo ( + /- sildenafil )
INTRODUCTION It is not known if statins will improve symptoms in patients with established erectile dysfunction ( ED ) .
AIM We carried out a systematic review and meta- analysis to assess the effect of statins on ED .