Conclusion The results of our meta- analysis suggest that AF was associated with decreased CRT benefits in patients with HF .
CRT , however , benefits patients with AF with AVJ ablation
Background Cardiac resynchronisation therapy ( CRT ) is beneficial in selected patients with heart failure ( HF ) in normal sinus rhythm ( NSR ) .
Digoxin Is Associated With Increased Shock Events and Electrical Storms in Patients With Implantable Cardioverter Defibrillators
Aim : Recently , digoxin use has been found to associate with higher mortality . Yet , potential mechanisms by which digoxin use increases mortality remain unclear . Increased arrhythmogenicity from digoxin use is one possibility . Thus , we aim ed to evaluate the relation between digoxin and shock events in patients with implantable cardioverter defibrillators ( ICDs ) . Methods : We performed a retrospective chart review of all patients with ICDs and at least 1 device interrogation at our institution between January 1 , 2012 , and January 1 , 2015 . We aim ed to cover 1 year of interrogation period . Patients with heart failure , atrial fibrillation , or both were included in the analysis . Patients were divided into 2 groups based on digoxin use , defined as use of digoxin for any period of time during ICD interrogation period . Incidence of ICD shock events and electrical storms and hospitalizations were compared between the 2 groups . Results : The study included 202 patients . Of those , 55 patients were on digoxin and 147 were not on digoxin .  Patients on digoxin were more likely to receive ICD shocks ( odds ratio [ OR ] = 2.5 , 95 % confidence interval [ 95 % CI ] = 1.01 - 6.18 , P = .04 ) and have increased risk of electrical storms ( P = .02 ) . Moreover , total hospitalizations were higher in digoxin users ( P = .02 ) . Multivariate logistic regression analysis also showed that digoxin use was an independent predictor of shock events ( OR = 4.07 , 95 % CI = 1.43 - 11.58 , P = .009 ) . Conclusion : Digoxin is associated with increased shock events and electrical storms in patients with ICDs ; however , large r and omized controlled studies are needed to confirm our findings
Conclusion The results of our meta- analysis suggest that AF was associated with decreased CRT benefits in patients with HF .
CRT , however , benefits patients with AF with AVJ ablation
Background Cardiac resynchronisation therapy ( CRT ) is beneficial in selected patients with heart failure ( HF ) in normal sinus rhythm ( NSR ) .