Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effect of weekly high-dose vitamin D3 supplementation on serum cholecalciferol concentrations in pregnant women
Vitamin D status is conventionally defined by the serum concentration of 25-hydroxyvitamin D. However , it has been proposed that the serum cholecalciferol concentration ( D3 ) also determines functional vitamin D sufficiency . The objective of this study was to describe the effect of weekly high-dose vitamin D3 supplementation on inter-dose serum D3 in pregnant women . We conducted a sub- study of a completed r and omized double-blind placebo-controlled trial of vitamin D3 ( 35,000 IU/week ) supplementation in late pregnancy ( AViDD trial ) in Dhaka , Bangladesh . This study included pregnant women enrolled at 26 - 29 weeks gestation who fully adhered to the prenatal supplement intervention for ≥8 consecutive weeks and for whom serum sample s were available for D3 analysis ( n=65 ) . Serum D3 was uniformly low at enrolment . Mean D3 increased and was maximal at 1 day after vitamin D dose administration ( 152.09nmol/L , SD 25.11nmol/L ) and remained significantly higher in VitD vs. Pl at 7 days ( 29.59nmol/L vs. 1.92nmol/L , p=0.007 ) . Daily average of the group mean D3 during the week following dosing was 66.97nmol/L in VitD versus 2.13nmol/L in Pl . In conclusion , serum D3 remained significantly elevated throughout the week following ≥8 consecutive weekly doses of 35,000 IU D3 in pregnant women . However , the clinical ly significant minimum threshold of serum D3 remains to be established
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .