The results indicated that there was no significant difference in the amelioration of BMI , HOMA-%S and HOMA-%B in T2DM patients between RS and the non-RS supplementation .
There was no significant difference between RS and non-RS supplements in patients with simple obesity .
Conclusion RS supplementation can ameliorate IR in T2DM , especially for the patients of T2DM with obesity , but not in simple obesity
Background Resistant starch ( RS ) is a starch that can be fermented by the microbial flora within gut lumen .
Insulin resistance ( IR ) is a pathophysiological condition related to diabetes and obesity .
RS could reduce blood glucose and ameliorate IR in animals , but its effect in human population is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of RS diet supplement on ameliorating IR in patients with T2DM and simple obesity .
Dietary treatment with rice containing resistant starch improves markers of endothelial function with reduction of postprandial blood glucose and oxidative stress in patients with prediabetes or newly diagnosed type 2 diabetes.
OBJECTIVE We aim ed to evaluate whether 4-week of dietary treatment with rice containing resistant starch reduces blood glucose and oxidative stress as well as improves endothelial function . METHODS Patients with impaired fasting glucose ( IFG ) , impaired glucose tolerance ( IGT ) or newly diagnosed type 2 diabetes ( n = 90 ) were r and omly assigned to either a group ingesting rice containing 6.51 g resistant starch daily or a control rice group for 4-weeks . We assessed fasting and postpr and ial levels of glucose and insulin , oxidative stress markers and endothelial function using reactive hyperemia peripheral arterial tonometry  ( RH-PAT ) . RESULTS The diet containing rice with resistant starch  reduced fasting insulin and insulin resistance , postpr and ial glucose ( P = 0.010 ) and insulin levels at 30 min , and glucose and insulin areas under the response curve after the st and ard meal . Rice with resistant starch also decreased urinary 8-epi-PGF(2α ) and plasma malondialdehyde ( MDA ) and increased the RH-PAT index ( P < 0.001 ) and total nitric oxide ( NO ) . Postpr and ial changes in glucose at 60 and 120 min and areas under the glucose response curve , MDA , RH-PAT , and total NO of the test group differed significantly from those in the control even after adjusting for baseline values . Overall , changes in the RH-PAT index correlated positively with changes in total NO ( r = 0.336 , P = 0.003 ) and superoxide dismutase activity ( r = 0.381 , P = 0.001 ) and negatively with changes in MDA ( r = -0.358 , P = 0.002 ) and 8-epi-PGF(2α ) . CONCLUSIONS In patients with IFG , IGT or newly diagnosed type 2 diabetes , 4-weeks of dietary treatment with rice containing resistant starch was associated with improved endothelial function with reduction of postpr and ial glucose and oxidative stress compared with control
The results indicated that there was no significant difference in the amelioration of BMI , HOMA-%S and HOMA-%B in T2DM patients between RS and the non-RS supplementation .
There was no significant difference between RS and non-RS supplements in patients with simple obesity .
Conclusion RS supplementation can ameliorate IR in T2DM , especially for the patients of T2DM with obesity , but not in simple obesity
Background Resistant starch ( RS ) is a starch that can be fermented by the microbial flora within gut lumen .
Insulin resistance ( IR ) is a pathophysiological condition related to diabetes and obesity .
RS could reduce blood glucose and ameliorate IR in animals , but its effect in human population is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of RS diet supplement on ameliorating IR in patients with T2DM and simple obesity .