Prolonged antioxidant vitamin E and /or C supplementation could be effective to improve endothelial function in non-obese T2DM subjects
Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus ( T2DM ) subjects .
The aim of this study was to systematic ally review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects .
Evaluation of the Local Effects of Vitamin E ( E-Mousse®) on Free Radicals in Diabetic Microangiopathy: A Randomized, Controlled Trial
The aims of the study were to evaluate the short-term effects of a new thermosensitive , vitamin E ( V-E ) mousse on local free radicals ( FR ) and skin flux in diabetic microangiopathy . A group of 40 patients with diabetic microangiopathy was included . The variation in measure ments of skin FR was evaluated by the D-Rom test . Subjects were between 45 and 65 years with type II diabetes and good metabolic control .  E-mousse ® , a thermoactive preparation of acetate vitamin E ( 20 % ) , was applied twice daily on the whole surface of the leg ( below knee ) and foot for 3 weeks . The contralateral leg was untreated acting as control .  Subjects with age between 45 and 65 years with type II diabetes ( diagnosed at least 5 years before ) and good metabolic control ( blood sugar < 180 mg/dL ) were included after informed consent . Patients with uncontrolled diabetes , peripheral vascular disease , and severe lower limbs infec tions were excluded .  Local free radicals ( FR ) and laser Doppler flux including the venoarteriolar response ( VAR ) were evaluated . The tolerability was evaluated by a semiquantitative score . Of the 40 included patients 34 completed the study . The 2 groups were comparable . At 3 weeks there was no decrease in FR in controls ; the decrease in the treatment group was 45.3 % ( p < 0.05 ) . Also in the treatment group RF decreased ( p < 0.05 ) and the VARveno improved from an average of 21 % to an average of 38 % ( p < 0.05 ) . No significant variations were observed in the control group . The variation in symptomatic score was from a total value of 8 to 5 in the control group and from 8 to 1 in the treatment group ( p < 0.02 ) . Their tolerability was good . In conclusion local treatment with E-mousse for 3 weeks in diabetic microangiopathy improves skin microcirculation and the metabolic condition as shown by the decrease in FR
Prolonged antioxidant vitamin E and /or C supplementation could be effective to improve endothelial function in non-obese T2DM subjects
Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus ( T2DM ) subjects .
The aim of this study was to systematic ally review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects .