In conclusion , a number of new active drugs were found to improve some cognitive functions , in particular verbal episodic memory .
Pharmacological cognitive enhancement refers to improvement in cognitive functions after drug use in healthy individuals .
This popular topic attracts attention both from the general public and the scientific community .
The objective was to explore innovative mechanisms of psychostimulant 's action , whose potential effectiveness was assessed in r and omized placebo-controlled trials ( RCTs ) .
Effect of aspirin on hypothalamic–pituitary–adrenal function and on neuropsychological performance in healthy adults: a pilot study
Rationale Hypothalamic – pituitary – adrenal axis dysregulation predicts poor clinical and biochemical response to antidepressants . Antiglucocorticoids have therapeutic benefits but most have a troublesome adverse event profile . Aspects of neuropsychological performance , notably working memory , are susceptible to corticosteroid modulation and are impaired in depression . Aspirin has been shown to attenuate the adrenocorticotropic hormone ( ACTH ) and cortisol response to physiological challenge suggesting its potential to act as an augmenting agent in depression . Objectives To examine the effect of sub-acute ( 300 mg daily for 7 days ) aspirin pre-treatment on the cortisol awakening response and the effect of acute ( 600 mg ) and sub-acute aspirin on the neuroendocrine and neuropsychological response to the arginine vasopressin analogue , desmopressin . Results We demonstrated that aspirin pre-treatment did not attenuate the cortisol or ACTH response to desmopressin but , as hypothesised , significantly reduced the cortisol awakening response and improved working memory . Conclusions Further studies to examine the impact of aspirin on neuropsychological performance and HPA axis function are warranted
In conclusion , a number of new active drugs were found to improve some cognitive functions , in particular verbal episodic memory .
Pharmacological cognitive enhancement refers to improvement in cognitive functions after drug use in healthy individuals .
This popular topic attracts attention both from the general public and the scientific community .
The objective was to explore innovative mechanisms of psychostimulant 's action , whose potential effectiveness was assessed in r and omized placebo-controlled trials ( RCTs ) .