This meta- analysis shows that oral tibolone treatment significantly lowers circulating Lp(a ) levels in postmenopausal women .
INTRODUCTION Circulating lipoprotein ( a ) ( Lp(a ) ) is a recognized risk factor for cardiovascular disease ( CVD ) .
Tibolone , a synthetic steroid , may lower Lp(a ) levels ; however , evidence of the effects of tibolone on Lp(a ) still remain to be defined .
Therefore , we investigated the effects of tibolone treatment on circulating Lp(a ) levels in postmenopausal women .
Comparison of the effects of tibolone and estrogen therapy on hemostasis in surgical menopause: a randomized, double-blind, placebo-controlled study.
OBJECTIVE To examine the effects of unopposed estrogen ( E ) and tibolone therapy on coagulation and natural anticoagulant systems in surgical menopause . DESIGN A r and omized , double-blind , placebo-controlled study . SETTING University hospital clinic in Turkey . PATIENT(S ) Ninety healthy surgically postmenopausal women . INTERVENTION(S ) Ninety surgically postmenopausal women were r and omized into three groups : unopposed conjugated ET ( 0.625 mg/d , group 1 ) , tibolone ( 2.5 mg/d , group 2 ) , and identical tablets of placebo ( group 3 ) . MAIN OUTCOME MEASURE(S ) Effects on parameters in the clotting cascade at baseline and after 24 weeks of treatment . RESULT ( S ) After 6 months , fibrinogen , lipoprotein ( a ) , and factor VIIa were decreased , and activated partial thromboplastin time was increased significantly in the ET group compared with in the placebo group . However , tibolone significantly decreased only the serum levels of factor VIIa and factor IX and prolonged the activated partial thromboplastin time , compared with placebo group . In addition , conjugated ET caused a significantly greater decrease in serum fibrinogen level than did tibolone . CONCLUSION ( S ) Neither E nor tibolone therapy led to activation of coagulation in the surgically menopausal women . Both preparations changed the overall hemostatic balance to a more fibrinolytic state
This meta- analysis shows that oral tibolone treatment significantly lowers circulating Lp(a ) levels in postmenopausal women .
INTRODUCTION Circulating lipoprotein ( a ) ( Lp(a ) ) is a recognized risk factor for cardiovascular disease ( CVD ) .
Tibolone , a synthetic steroid , may lower Lp(a ) levels ; however , evidence of the effects of tibolone on Lp(a ) still remain to be defined .
Therefore , we investigated the effects of tibolone treatment on circulating Lp(a ) levels in postmenopausal women .