Conclusion Probiotic/synbiotic use  improves aminotransaminase levels and reduces proinflammatory marker high-sensitivity C-reactive protein and liver fibrosis in NAFLD patients
Background Nonalcoholic fatty liver disease ( NAFLD ) is the most prevalent chronic liver disease worldwide .
The pathogenesis of NAFLD is complex and multifactorial .
There is growing evidence that altered gut microbiota plays a key role in NAFLD progression .
Probiotics/synbiotics , by modifying gut microbiota , may be a promising treatment choice for NAFLD management .
Aim The aim of this study was to study the effect of probiotics/synbiotics on various laboratory and radiographic parameters in NAFLD management .
Lack of efficacy of Lactobacillus GG in reducing pulmonary exacerbations and hospital admissions in children with cystic fibrosis: A randomised placebo controlled trial.
BACKGROUND Intestinal dysbiosis has been described in Cystic Fibrosis ( CF ) and probiotics have been proposed to restore microbial composition . Aim of the study was to investigate the effects of Lactobacillus rhamnosus GG ( LGG ) on clinical outcomes in children with cystic fibrosis ( CF ) . METHODS A multicentre , r and omised double-blind , clinical trial was conducted in children with CF . After 6months of baseline assessment , enrolled children ( 2 to 16years of age ) received Lactobacillus GG ( 6 × 109CFU/day ) or placebo for 12months . Primary outcomes were proportion of subjects with at least one pulmonary exacerbation and hospitalisation over 12months . Secondary endpoints were total number of exacerbations and hospitalisations , pulmonary function , and nutritional status . RESULTS Ninety-five patients were enrolled ( 51/95 female ; median age of 103±50months ) . In a multivariate GEE logistic analysis , the odds of experiencing at least one exacerbation was not significantly different between the two groups , also after adjusting for the presence of different microbial organisms and for the number of pulmonary exacerbations within 6months before r and omisation ( OR 0.83 ; 95 % CI 0.38 to 1.82 , p=0.643 ) . Similarly , LGG supplementation did not significantly affect the odds of hospitalisations ( OR 1.67 ; 95 % CI 0.75 to 3.72 , p=0.211 ) . No significant difference was found for body mass index and FEV1 . CONCLUSIONS LGG supplementation had no effect on respiratory and nutritional outcomes in this large study population of children with CF under stringent r and omised clinical trial conditions . Whether earlier interventions , larger doses , or different strains of probiotics may be effective is unknown
Conclusion Probiotic/synbiotic use  improves aminotransaminase levels and reduces proinflammatory marker high-sensitivity C-reactive protein and liver fibrosis in NAFLD patients
Background Nonalcoholic fatty liver disease ( NAFLD ) is the most prevalent chronic liver disease worldwide .
The pathogenesis of NAFLD is complex and multifactorial .
There is growing evidence that altered gut microbiota plays a key role in NAFLD progression .
Probiotics/synbiotics , by modifying gut microbiota , may be a promising treatment choice for NAFLD management .
Aim The aim of this study was to study the effect of probiotics/synbiotics on various laboratory and radiographic parameters in NAFLD management .