In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .
Breast conservation and prolonged chemotherapy for locally advanced breast cancer: the University of Michigan experience.
PURPOSE To determine whether breast conservation and prolonged neoadjuvant chemotherapy have efficacy in locally advanced breast cancer ( LABC ) , as measured by survival and rate of breast conservation . MATERIAL S AND METHODS Eighty-nine patients with stage III disease were enrolled at the University of Michigan ( UM ) onto a prospect i ve nonr and omized trial . Patients received nine 21-day cycles of neoadjuvant chemohormonal therapy that consisted of doxorubicin 30 mg/m2 and cyclophosphamide 750 mg/m2 intravenously on day 1 , conjugated estrogens 0.625 mg orally twice daily on days 6 to 8 , methotrexate 40 mg/m2 and fluorouracil 500 mg/m2 intravenously on day 8 , and tamoxifen 10 mg orally twice daily on days 9 to 14 . Patients with a negative biopsy received radiation only , while those with residual disease underwent mastectomy and postoperative radiotherapy . Eight more cycles of chemohormonal therapy were administered after local-regional therapy . RESULTS The clinical response rate to neoadjuvant therapy was 97 % , 28 % of patients had a complete pathologic response evaluated at biopsy . Five-year overall and disease-free survival probabilities were 54 % and 44 % , respectively . The median disease-free survival time was 2.4 years . The 5-year actuarial rates of local-regional control with local failure as only first failure were 82 % and 78 % following radiotherapy , and mastectomy and radiotherapy , respectively ( P = .99 ) . CONCLUSION Prolonged neoadjuvant chemohormonal therapy and biopsy-driven local therapy have efficacy in LABC , with 28 % of patients being c and i date s for breast conservation and a 5-year overall survival rate of 54 %
In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .