RESULTS The instruments most frequently used were single-item VAS and Biberoglu and Behrman pain score , while multidimensional inventories were used in few studies .
The results of clinical studies in CPP are more frequently based on one-dimensional measurements .
RATIONALE Many types of  pain assessment are available to research ers carrying out clinical trials in chronic pelvic pain ( CPP ) , ranging from a single-item scale to multidimensional inventories .
AIM Our objective was to investigate which assessment s of pain are more commonly used in clinical trials on CPP .
Efficacy of melatonin in the treatment of endometriosis: A phase II, randomized, double-blind, placebo-controlled trial
& NA ; Melatonin reduced pain scores and analgesic use , and improved sleep quality in endometriosis‐associated chronic pelvic pain . Melatonin modulates the secretion of brain‐derived neurotrophic factor independently of its analgesic effect in endometriosis . & NA ; Endometriosis‐associated chronic pelvic pain ( EACPP ) presents with an intense inflammatory reaction . Melatonin has emerged as an important analgesic , antioxidant , and antiinflammatory agent . This trial investigates the effects of melatonin compared with a placebo on EACPP , brain‐derived neurotrophic factor ( BDNF ) level , and sleep quality . Forty females , aged 18 to 45 years , were r and omized into the placebo ( n = 20 ) or melatonin ( 10 mg ) ( n = 20 ) treatment groups for a period of 8 weeks . There was a significant interaction ( time vs group ) regarding the main outcomes of the pain scores as indexed by the visual analogue scale on daily pain , dysmenorrhea , dysuria , and dyschezia ( analysis of variance , P < 0.01 for all analyses ) . Post hoc analysis showed that compared with placebo , the treatment reduced daily pain scores by 39.80 % ( 95 % confidence interval [ CI ] 12.88–43.01 % ) and dysmenorrhea by 38.01 % ( 95 % CI 15.96–49.15 % ) . Melatonin  improved sleep quality , reduced the risk of using an analgesic by 80 % , and reduced BNDF levels independently of its effect on pain . This study provides additional evidence regarding the analgesic effects of melatonin on EACPP and melatonin ’s ability to improve sleep quality . Additionally , the study revealed that melatonin modulates the secretion of BDNF and pain through distinct mechanisms
RESULTS The instruments most frequently used were single-item VAS and Biberoglu and Behrman pain score , while multidimensional inventories were used in few studies .
The results of clinical studies in CPP are more frequently based on one-dimensional measurements .
RATIONALE Many types of  pain assessment are available to research ers carrying out clinical trials in chronic pelvic pain ( CPP ) , ranging from a single-item scale to multidimensional inventories .
AIM Our objective was to investigate which assessment s of pain are more commonly used in clinical trials on CPP .