The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .
No significant effect of angiotensin II receptor blockade on intermediate cardiovascular end points in hemodialysis patients.
Agents blocking the renin-angiotensin-aldosterone system are frequently used in patients with end-stage renal disease , but whether they exert beneficial cardiovascular effects is unclear . Here the long-term effects of the angiotensin II receptor blocker , irbesartan , were studied in hemodialysis patients in a double-blind r and omized  placebo-controlled 1-year intervention trial using a predefined systolic blood pressure target of 140 mm Hg ( SAFIR study ) . Each group of 41 patients did not differ in terms of age , blood pressure , comorbidity , antihypertensive treatment , dialysis parameters , and residual renal function .  Brachial blood pressure decreased significantly in both groups , but there was no significant difference between placebo and irbesartan .  Use of additional antihypertensive medication , ultrafiltration volume , and dialysis dosage were not different . Intermediate cardiovascular end points such as central aortic blood pressure , carotid-femoral pulse wave velocity , left ventricular mass index , N-terminal brain natriuretic prohormone , heart rate variability , and plasma catecholamines were not significantly affected by irbesartan treatment . Changes in systolic blood pressure during the study period significantly correlated with changes in both left ventricular mass and arterial stiffness . Thus , significant effects of irbesartan on intermediate cardiovascular end points beyond blood pressure reduction were absent in hemodialysis patients
The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .