Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients.
BACKGROUND Experimental evidence suggests a lipid-independent effect of statins on endothelial function and nitric oxide ( NO ) availability in humans . We investigated whether improvement in NO availability in hypercholesterolemia can be achieved rapidly with statins before lipid-lowering therapy is complete . METHODS We studied 41 patients ( 52 + /- 11 years ) with low-density lipoprotein ( LDL ) cholesterol > or = 130 mg/dL ( 179 + /- 45 mg/dL ) r and omly assigned to treatment either with atorvastatin ( 20 mg/day ) or cerivastatin ( 0.4 mg/day ) .  Endothelium-dependent vasodilation of the forearm vasculature was measured by plethysmography and intra-arterial infusion of acetylcholine ( ACh ) after 3 days ( n = 18 ) and 14 days ( n = 39 ) of treatment . NO availability and oxidative stress were assessed by coinfusion of l-NMMA and vitamin C. RESULTS After 3 days of treatment , LDL-cholesterol decreased by 11.9 % with a further decrease to 29.6 % after 14 days ( P < .001 ) . Endothelium-dependent vasodilation improved by + 46.7 % after 3 days of statin therapy compared with before therapy ( ACh 48 microg/min : + 15.7 + /- 10.6 vs + 10.7 + /- 10.8 mL/min per 100 mL , P < .05 ) . No further improvement in endothelium-dependent vasodilation ( + 42.7 % compared with before therapy ) could be demonstrated after 14 days of treatment ( ACh 48 microg/min : + 17.7 + /- 10.3 vs + 12.4 + /- 9.3 mL/min per 100 mL before therapy , P < .001 ) . Coinfusion of ACh plus vitamin C was able to improve endothelium-dependent vasodilation before but not after 3 or 14 days of statin therapy either . The improvement in endothelium-dependent vasodilation after therapy was no longer observed when the NO-synthase inhibitor l-NMMA was coinfused together with ACh . CONCLUSIONS Short-term lipid-lowering therapy with statins is able to improve endothelial function and NO availability almost completely after 3 days in hypercholesterolemic patients probably by decreasing oxidative stress . This improvement seems to be more rapid than the accompanying decline in LDL-cholesterol and not related to these lipid changes . This finding can support the concept of lipid-independent effects of statins in humans
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .