A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?
Effects of exercise on fatigue, sleep, and performance: a randomized trial.
PURPOSE / OBJECTIVES To compare usual care with a home-based individualized exercise program ( HBIEP ) in patients receiving intensive treatment for multiple myeloma ( MM ) and epoetin alfa therapy .  DESIGN R and omized trial with repeated measures of two groups ( one experimental and one control ) and an approximate 15-week experimental period . SETTING Outpatient setting of the Myeloma Institute for Research and Therapy at the Rockfellow Cancer Center at the University of Arkansas for Medical Sciences . SAMPLE 187 patients with newly diagnosed MM enrolled in a separate study evaluating effectiveness of the Total Therapy regimen , with or without thalidomide . METHODS Measurements included the Profile of Mood States fatigue scale , Functional Assessment of Cancer Therapy-Fatigue , ActiGraph ® recordings , 6-Minute Walk Test , and hemoglobin levels at baseline and before and after stem cell collection . Descriptive statistics were used to compare demographics and treatment effects , and repeated measures analysis of variance was used to determine effects of HBIEP . MAIN RESEARCH VARIABLES Fatigue , nighttime sleep , performance ( aerobic capacity ) as dependent or outcome measures , and HBIEP combining strength building and aerobic exercise as the independent variable . FINDINGS Both groups were equivalent for age , gender , race , receipt of thalidomide , hemoglobin levels , and type of treatment regimen for MM . No statistically significant differences existed among the experimental and control groups for fatigue , sleep , or performance ( aerobic capacity ) . Statistically significant differences ( p < 0.05 ) were found in each of the study outcomes for all patients as treatment progressed and patients experienced more fatigue and poorer nighttime sleep and performance ( aerobic capacity ) . CONCLUSIONS The effect of exercise seemed to be minimal on decreasing fatigue , improving sleep , and improving performance ( aerobic capacity ) . IMPLICATION S FOR NURSING Exercise is safe and has physiologic benefits for patients undergoing MM treatment ; exercise combined with epoetin alfa helped alleviate anemia
A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?