The most important predictive factors for upper limb recovery following stroke appears to the initial severity of motor impairment or function
Objective : To systematic ally review and summarize the current available literature on prognostic variables relating to upper limb recovery following stroke .
To identify which , if any variables predict upper limb recovery following stroke .
Ipsilateral Motor Responses to Focal Transcranial Magnetic Stimulation in Healthy Subjects and Acute-Stroke Patients
Background and Purpose — Prevalence and characteristics of ipsilateral upper limb motor-evoked potentials ( MEPs ) elicited by focal transcranial magnetic stimulation ( TMS ) were compared in healthy subjects and patients with acute stroke . Methods — Sixteen healthy subjects and 25 patients with acute stroke underwent focal TMS at maximum stimulator output over motor and premotor cortices . If present , MEPs evoked in muscles ipsilateral to TMS were analyzed for latency , amplitude , shape , and center of gravity ( ie , preferential coil location to elicit them ) . In stroke patients , possible relationships between early ipsilateral responses and functional outcome at 6 months were sought . Results — With relaxed or slightly contracting target muscle , maximal TMS over the motor cortex failed to elicit ipsilateral MEPs in the first dorsal interosseous ( FDI ) or biceps of any of 16 normal subjects . In 5 of 8 healthy subjects tested , ipsilateral MEPs with latencies longer than contralateral MEPs were evoked in FDI muscle ( in biceps , 6 of 8 subjects ) during strong ( > 50 % maximum ) contraction of the target muscle . In 15 of 25 stroke patients , ipsilateral MEPs in the unaffected relaxed FDI ( in biceps , 6 of 25 stroke patients ) were evoked by stimulation of premotor areas of the affected hemisphere . Their latencies were shorter than those that MEPs evoked in the same muscle by stimulation of the motor cortex of the contralateral unaffected hemisphere . Such responses were never obtained in normal subjects and were mostly observed in patients with subcortical infa rcts . Patients harboring these responses had slightly better bimanual dexterity after 6 months . Conclusions — Ipsilateral MEPs obtained in healthy individuals and stroke patients have different characteristics and probably different origins . In the former , they are probably conveyed via corticoreticulospinal or corticopropriospinal pathways , whereas in the latter , early ipsilateral MEPs could originate in hyperexcitable premotor areas
The most important predictive factors for upper limb recovery following stroke appears to the initial severity of motor impairment or function
Objective : To systematic ally review and summarize the current available literature on prognostic variables relating to upper limb recovery following stroke .
To identify which , if any variables predict upper limb recovery following stroke .