The MFSI-SF demonstrated moderate test-retest reliability in a small number of studies .
The MFSI-SF fatigue subscales were positively correlated with measures of distress , depressive , and anxious symptoms .
Purpose Fatigue is a subjective complaint that is believed to be multifactorial in its etiology and multidimensional in its expression .
Fatigue may be experienced by individuals in different dimensions as physical , mental , and emotional tiredness .
The purpose s of this study were to review and characterize the use of the 30-item Multidimensional Fatigue Symptom Inventory-Short Form ( MFSI-SF ) in published studies and to evaluate the available evidence for its psychometric properties .
Phase II nonrandomized study of the efficacy and safety of COX-2 inhibitor celecoxib on patients with cancer cachexia
Chronic inflammation is one of the main features of cancer cachexia . Experimental and clinical studies showed that cyclooxygenase-2 inhibitors , such as celecoxib , may be beneficial in counteracting major symptoms of this devastating syndrome . We carried out a prospect i ve phase II clinical trial to test the safety and effectiveness of an intervention with the COX-2 inhibitor celecoxib ( 300 mg/day for 4 months ) on key variables of cachexia ( lean body mass , resting energy expenditure , serum levels of proinflammatory cytokines , and fatigue ) in patients with advanced cancer at different sites . A sample of 24 patients was enrolled from January to December 2008 and all were deemed assessable . A significant increase of lean body mass and a significant decrease of TNF-α were observed . Moreover , an improvement of grip strength , quality of life , performance status , and Glasgow prognostic score was shown . There were no grade 3/4 toxicities . Patient compliance was very good ; no patient had to reduce the celecoxib dosage nor interrupt treatment . Our results showed that the COX-2 selective inhibitor celecoxib is an effective single agent for the treatment of cancer cachexia . Although the treatment of cancer cachexia , a multifactorial syndrome , is more likely to yield success with a multitargeted approach ; in the present study , we were able to show that a treatment , such as celecoxib , addressing a single target , albeit very important as chronic inflammation , could have positive effects . Therefore , phase III clinical trials are warranted to test the efficacy and safety of celecoxib
The MFSI-SF demonstrated moderate test-retest reliability in a small number of studies .
The MFSI-SF fatigue subscales were positively correlated with measures of distress , depressive , and anxious symptoms .
Purpose Fatigue is a subjective complaint that is believed to be multifactorial in its etiology and multidimensional in its expression .
Fatigue may be experienced by individuals in different dimensions as physical , mental , and emotional tiredness .
The purpose s of this study were to review and characterize the use of the 30-item Multidimensional Fatigue Symptom Inventory-Short Form ( MFSI-SF ) in published studies and to evaluate the available evidence for its psychometric properties .