Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Is a daily supplementation with 40 microgram vitamin D3 sufficient? A randomised controlled trial
Purpose The effect of 40 μg ( 1,600 IU ) per day of vitamin D3 on serum 25-hydroxyvitamin D ( 25(OH)D ) and markers of bone and mineral metabolism was evaluated . Methods This intervention study was design ed as a double-blind r and omised controlled trial . Forty-five community-dwelling subjects ( 32 females ) , age 55–84 years , at 58 ° North latitude were supplemented for 1 year with 40 μg vitamin D3 plus 1,000 mg calcium per day , or with 1,000 mg calcium per day for controls  . Safety parameters and 25(OH)D , intact parathyroid hormone ( PTH ) , ionized calcium , bone-specific alkaline phosphatase ( BALP ) , and tartrate-resistant acid phosphatase isoform 5b ( TRACP5b ) were measured over the study period . Results All subjects supplemented with vitamin D3 reached a 25(OH)D level above 50 nmol/L. Mean ( SD ) serum 25(OH)D increased from 50.4 ( 13.5 ) nmol/L to 84.2 ( 17.5 ) nmol/L , range 55.0–125.0 nmol/L in the vitamin D3 supplemented group and the corresponding levels for the control group were 47.3 ( 14.1 ) nmol/L and 45.7 ( 13.4 ) nmol/L , range 26.0–73.0 nmol/L. No serious adverse event was recorded and the highest 25(OH)D level reached , 125.0 nmol/L , is well below toxic levels . BALP and TRACP5b did not change significantly over the study period . Conclusions This trial suggests that a daily supplementation with 40 μg vitamin D3 is sufficient to secure a 25(OH)D level of 50 nmol/L. No side effects were observed in the study group
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .