There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Influence of long-chain polyunsaturated fatty acid formula feeds on vitamin E status in preterm infants.
It has been recommended to supplement formulas for preterm infants with n-3 and n-6 long-chain polyunsaturated fatty acids ( LCP ) to improve growth , visual acuity , and neurodevelopmental performance . However , large amounts of LCP may increase lipid peroxidation and oxidative stress in preterm infants . We investigated if , under high supplementation of natural tocopherols , LCP addition to formula can be performed safely without causing tocopherol depletion in cell membranes . Thirty-one healthy preterm infants with gestational ages from 28 to 32 weeks were evaluated in a prospect i ve , r and omized study from birth to day 42 . Nine infants received an n-3 and n-6 LCP-enriched formula ( A ) , eleven infants a st and ard formula ( B ) , and eleven infants breast milk ( control group ) . Alpha- and gamma-tocopherol extracts were added to both formulas , amounting to five times the value in breast milk ( 2.3 mg/dL in both formulas versus 0.45 mg/dL in breast milk ) . Erythrocyte arachidonic acid ( AA ) and docosahexaenoic acid ( DHA ) in the phosphatidylethanolamine fraction were similar in the three groups over the study period , whereas a significant reduction of erythrocyte AA and DHA could be detected in the phosphatidylcholine fraction in all three groups from day 14 onwards , when compared to respective cord blood values , with lowest values in the st and ard formula group . Amazingly , levels of alpha- and gamma-tocopherol were higher in plasma , erythrocytes , platelets , monocytes , and polymorphonuclear leukocytes with LCP supplementation as compared to st and ard formula and breast milk from day 7 onwards , whereas in buccal mucosal cells , this was not the case until day 42 . Gammatocopherol uptake in the LCP-supplemented group was also significantly higher in all cell fractions studied from day 7 onwards . We therefore hypothesize that the LCP supplementation used in formula A improves tocopherol solubility and stability in biological membranes . Under high-dose vitamin E addition to n-3 and n-6 LCP-supplemented formula , no evidence for tocopherol depletion and furthermore , high accumulation of tocopherols , can be detected in healthy preterm infants
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .