No significant differences were observed for weight , waist circumference , fat mass , blood lipids ( i.e. total cholesterol , LDL-cholesterol , HDL-cholesterol , triacylglycerols ) , C-reactive protein , diastolic and systolic blood pressure , fasting glucose and glycosylated hemoglobin .
Sensitivity analysis of high quality RCTs confirmed the data of the primary analyses , while exclusion of studies with diabetic subjects result ed in an additional benefit of high-protein diets with respect to a more marked increase in HDL-cholesterol .
Conclusion According to the present meta- analysis of long-term RCTs , high-protein diets exerted neither specific beneficial nor detrimental effects on outcome markers of obesity , cardiovascular disease or glycemic control .
Background Meta-analyses of short-term studies indicate favorable effects of higher protein vs. lower protein diets on health outcomes like adiposity or cardiovascular risk factors , but their long-term effects are unknown .
Effect of normal-fat diets, either medium or high in protein, on body weight in overweight subjects: a randomised 1-year trial
BACKGROUND : We have previously reported that a fat-reduced high-protein diet had more favourable effects on body weight loss over 6 months than a medium-protein diet . OBJECTIVE : To extend this observation by a further 6–12 months less stringent intervention and a 24 months follow-up . DESIGN : A r and omised 6 months strictly controlled dietary intervention followed by 6–12 months dietary counselling period , and a subsequent 24 months follow-up , comparing an ad libitum , fat-reduced diet ( 30 % of energy ) either high in protein ( 25 % of energy , HP ) or medium in protein ( 12 % of energy , MP).SUBJECTS : A total of 50 overweight and obese subjects ( age : 19–55 y ; BMI : 26–34 kg/m2 ) . MEASUREMENTS : Change in body weight , body composition and blood parameters . RESULTS : After 6 months , the HP group ( n=23 ) achieved a greater weight loss than the MP group ( n=23 ) ( 9.4 vs 5.9 kg ) ( P<0.01 ) . After 12 months , 8 % had dropped out in the HP vs 28 % in the MP group ( P<0.07 ) . After 12 months , the weight loss was not significantly greater among the subjects in the HP group ( 6.2 and 4.3 kg ) , but they had a 10 % greater reduction in intra-abdominal adipose tissue and more in the HP group ( 17 % ) lost > 10 kg than in the MP ( P<0.09 ) . At 24 months , both groups tended to maintain their 12 months weight loss , but more than 50 % were lost to follow-up . CONCLUSION : A fat-reduced diet high in protein seems to enhance weight loss and provide a better long-term maintenance of reduced intra-abdominal fat stores
No significant differences were observed for weight , waist circumference , fat mass , blood lipids ( i.e. total cholesterol , LDL-cholesterol , HDL-cholesterol , triacylglycerols ) , C-reactive protein , diastolic and systolic blood pressure , fasting glucose and glycosylated hemoglobin .
Sensitivity analysis of high quality RCTs confirmed the data of the primary analyses , while exclusion of studies with diabetic subjects result ed in an additional benefit of high-protein diets with respect to a more marked increase in HDL-cholesterol .
Conclusion According to the present meta- analysis of long-term RCTs , high-protein diets exerted neither specific beneficial nor detrimental effects on outcome markers of obesity , cardiovascular disease or glycemic control .
Background Meta-analyses of short-term studies indicate favorable effects of higher protein vs. lower protein diets on health outcomes like adiposity or cardiovascular risk factors , but their long-term effects are unknown .