We conclude that both serum and erythrocyte folate values reflect folate intake ; however , serum folate reacts more rapidly to folate intake than erythrocyte folate .
As to health outcomes , we found no evidence indicating that additional intake of folate can influence haematological parameters in non-anaemic paediatric patients .
We were unable to find evidence of a favourable effect of folate supplementation on the growth of infants .
However , the limited data available suggest that supplementing the diet of low-birth-weight infants with folic acid may moderate the rapid fall of serum and red cell folate in the first months of life
The aim of this systematic review was to collect all available r and omized controlled trials on the effect of folate supplementation on folate status and health outcomes within the paediatric age group .
Homocysteine lowering with folic acid supplements in children: Effects on blood pressure
Abstract Hyperhomocysteinemia is emerging as an independent predictor of cardiovascular disease and hypertension among children . The aim of the study was to examine the effects of oral folic acid on homocysteine and blood pressure .  Folic acid supplementation has been found to reduce homocysteine levels and in some cases blood pressure .  Five hundred and twenty children participated in the study , and 26 of them were found to be hyperhomocysteinemic ; 20 of these children r and omly received 5 mg oral folic acid supplement while the other six children were the controls . Serum homocysteine ( P < 0.001 ) levels as well as systolic ( P < 0.001 ) and diastolic ( P = 0.045 ) blood pressure were statistically significantly decreased in the intervention group compared with the controls , while folic acid levels were statistically significantly increased ( P < 0.001 ) . Total serum homocysteine levels were correlated with age , serum folate , body mass index , and blood pressure . It appears that folic acid may be a safe and effective supplement to reduce homocysteine and possibly blood pressure , which consequently may prevent cardiovascular disease in children in early life
We conclude that both serum and erythrocyte folate values reflect folate intake ; however , serum folate reacts more rapidly to folate intake than erythrocyte folate .
As to health outcomes , we found no evidence indicating that additional intake of folate can influence haematological parameters in non-anaemic paediatric patients .
We were unable to find evidence of a favourable effect of folate supplementation on the growth of infants .
However , the limited data available suggest that supplementing the diet of low-birth-weight infants with folic acid may moderate the rapid fall of serum and red cell folate in the first months of life
The aim of this systematic review was to collect all available r and omized controlled trials on the effect of folate supplementation on folate status and health outcomes within the paediatric age group .