Conclusion The systematic review and meta- analysis support that probiotics are superior to placebo in NAFLD patients and could be utilized as a common complementary therapeutic approach
Background and Aims Probiotics was considered as a potential therapy for nonalcoholic fatty liver disease ( NAFLD ) without approval and comprehensive assessment in recent years , which call for a meta- analysis .
Effects of a synbiotic containing Lactobacillus acidophilus ATCC 4962 on plasma lipid profiles and morphology of erythrocytes in hypercholesterolaemic pigs on high- and low-fat diets.
The aim of this study was to evaluate the effect of a synbiotic containing Lactobacillus acidophilus ATCC 4962 , fructooligosaccharide , inulin and mannitol on plasma lipid profiles and erythrocyte membrane properties in hypercholesterolaemic pigs on high- and low-fat diets . Twenty-four white male L and race pigs were r and omly allocated to four treatment groups for 8 weeks ( n 6 ) . Treatment factors were the supplementation of synbiotic ( with and without ) and dietary fat ( 5 and 15 % ) . The supplementation of synbiotic reduced plasma total cholesterol ( P = 0.001 ) , TAG ( P = 0.002 ) and LDL-cholesterol ( P = 0.045 ) for both dietary fats . A higher concentration of esterified-cholesterol in HDL of pigs supplemented with synbiotic than the control regardless of dietary fat ( P = 0.036 ) indicated that cholesterol was reduced in the form of cholesteryl esters . Reduced concentration of cholesteryl esters ( P < 0.001 ) and increased concentration of TAG ( P = 0.042 ) in LDL of pigs on synbiotic suggested that LDL-cholesterol was reduced via the hydrolysis of smaller and denser LDL particles . The erythrocytes of pigs without any synbiotic showed more prevalence of spur cells than those given the synbiotic , as supported by the higher cholesterol : phospholipid ratio in erythrocytes ( P = 0.001 ) . Also , membrane fluidity and rigidity were improved as supported by the decreased fluorescence anisotropies in the Hb-free erythrocyte membrane of pigs given synbiotic ( P < 0.001 ) . The administration of the synbiotic reduced plasma TAG , total cholesterol and LDL-cholesterol in hypercholesterolaemic pigs , possibly in the form of cholesteryl esters , via the interrelated pathways of lipid transporters ( VLDL , LDL and HDL ) . The synbiotic also reduced deformation of erythrocytes via improved membrane fluidity and permeability
Conclusion The systematic review and meta- analysis support that probiotics are superior to placebo in NAFLD patients and could be utilized as a common complementary therapeutic approach
Background and Aims Probiotics was considered as a potential therapy for nonalcoholic fatty liver disease ( NAFLD ) without approval and comprehensive assessment in recent years , which call for a meta- analysis .