Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .
The impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes.
OBJECTIVE The purpose of the present study was to assess the impact of Mg + Zn , Vitamins C + E , and combination of these micronutrients on serum lipid and lipoprotein profiles in type 2 diabetic patients . MATERIAL S AND METHODS In a r and omized , double-blind , placebo controlled clinical trial , 69 type 2 diabetic patients were r and omly divided into four groups , each group receiving one of the following daily supplement for 3 months ; group M : 200 mg Mg and 30 mg Zn ( n = 16 ) , group V : 200 mg Vitamin C and 150 mg Vitamin E ( n = 18 ) , group MV : minerals plus vitamins ( n = 17 ) , group P : placebo ( n = 18 ) . Fasting blood and urine sample s were collected at the beginning and at the end of the trial . Serum triglyceride , total cholesterol , high density lipoprotein cholesterol ( HDL-c ) and low density lipoprotein cholesterol ( LDL-c ) were measured enzymatically . Apolipoproteins ( apo ) A1 and B were measured by immunoturbidimetric method . Adjustment for differences in baselines covariates and changes in variables during study were performed by analysis of covariance using general linear models . RESULTS Results indicate that after 3 months of supplementation mean serum levels of HDL-c and apo A1 increased significantly in the MV group by 24 % ( 50.4 + /-19.3 mg/dl versus 40.6 + /- 10.8 mg/dl ) and 8.8 % ( 169.8 + /- 33.8 mg/dl versus 156.1 + /- 23.9 mg/dl ) , respectively ( P < 0.01 ) . There were no significant changes in the levels of these parameters in the other three groups . Serum levels of total cholesterol , LDL-c , triglyceride , and apo B were not altered after supplementation in all four groups . CONCLUSION It is concluded that since co-supplementation of Mg , Zn , Vitamins C and E significantly increases HDL-c and apo A1 , supplementation of these micronutrients could be recommended for the type 2 diabetic patients based on their daily requirements
Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .