Serious adverse events attributable to vitamin D supplementation were rare across all studies .
On the basis of studies review ed to date , the strongest evidence supports further research into adjunctive vitamin D therapy for tuberculosis , influenza , and viral upper respiratory tract illnesses .
OBJECTIVE To review the existing human controlled intervention studies of vitamin D as adjunctive therapy in setting s of infection and provide recommendations for design and implementation of future studies in this field on the basis of the evidence review ed .
Calcitriol (1,25-dihydroxy-vitamin D3) coadministered with influenza vaccine does not enhance humoral immunity in human volunteers.
Calcitriol , also known as 1,25-dihydroxy-vitamin D3 , is a steroid hormone that has been shown to have effects on cytokine production and lymphocyte proliferation . Coadministration of calcitriol with trivalent influenza vaccine in mice enhanced both mucosal and systemic antibody responses . We studied the effects of calcitriol coadministered with a commercially available influenza vaccine in 175 human volunteers in this double-blind , placebo controlled clinical trial . Subjects that received calcitriol experienced more pain at the injection site compared with placebo recipients . No significant differences in hemagglutination inhibition titers against H1N1 , H3N2 , or influenza B antigens were detected at 1 or 3 months postvaccination . We conclude that coadministration of 1.0 microg of calcitriol at a site adjacent to influenza vaccination does not enhance humoral immunity in human volunteers
Serious adverse events attributable to vitamin D supplementation were rare across all studies .
On the basis of studies review ed to date , the strongest evidence supports further research into adjunctive vitamin D therapy for tuberculosis , influenza , and viral upper respiratory tract illnesses .
OBJECTIVE To review the existing human controlled intervention studies of vitamin D as adjunctive therapy in setting s of infection and provide recommendations for design and implementation of future studies in this field on the basis of the evidence review ed .