Current evidence indicates that inverse association between leptin level and 25(OH)D concentration was observed in observational studies , which was not demonstrated in intervention studies with high heterogeneity .
We aim ed to investigate the potential association between vitamin D and serum leptin levels by pooling together the results from observational studies and clinical trials .
The relationship between adipokines, osteocalcin and bone quality in chronic kidney disease.
OBJECTIVES Osteocalcin , a small peptide secreted by osteoblasts , has been recently described as a circulating hormone involved in the regulation of energy metabolism . In addition , experimental data suggest a regulation of adipocytes by bone , with a stimulation of adiponectin synthesis by osteocalcin and an inverse relationship between serum adiponectin level and bone mineral density ( BMD ) . However , this relationship has not been explored during chronic kidney disease ( CKD ) . METHODS  Osteocalcin , adiponectin and leptin  were prospect ively measured in a cohort of 61 CKD patients . A new non-invasive 3D bone imaging technique was performed ( high-resolution peripheral quantitative computed tomography , HR-pQCT ) , measuring volumetric BMD ( vBMD ) and microarchitecture parameters at the distal tibia . RESULTS Patients ' mean age was 67.2 + /- 13.9 years and mean GFR 33 + /- 12 mL/min/1.73 m(2 ) . We found a positive association between serum osteocalcin and adiponectin ( r = 0.29 , P = 0.021 ) . Univariate analysis showed inverse correlations between serum adiponectin and total vBMD ( r = -0.33 , P = 0.01 ) , cortical thickness ( r = -0.34 , P = 0.008 ) and trabecular vBMD ( r = -0.27 , P = 0.04 ) . These associations remained significant in multivariate analysis between serum adiponectin and total vBMD , cortical vBMD and cortical thickness . CONCLUSION We report for the first time an inverse relationship between bone density and adiponectin , as well as a positive association between osteocalcin and adiponectin in CKD II-IV patients
Current evidence indicates that inverse association between leptin level and 25(OH)D concentration was observed in observational studies , which was not demonstrated in intervention studies with high heterogeneity .
We aim ed to investigate the potential association between vitamin D and serum leptin levels by pooling together the results from observational studies and clinical trials .