Conclusions Whole flaxseed , but not flaxseed oil and lignan extract , has significant effects on improving glycemic control .
Context The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent .
Objective The present study aim ed to systematic ally review and analyze r and omized controlled trials assessing the effects of flaxseed consumption on glycemic control .
Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study
Abstract A two-arm r and omized open labeled controlled clinical trial was conducted on 50 patients with non-alcoholic fatty liver disease ( NAFLD ) . Participants were assigned to take either a lifestyle modification ( LM ) , or LM + 30 g/day brown milled flaxseed for 12 weeks . At the end of the study , body weight , liver enzymes , insulin resistance and hepatic fibrosis and steatosis decreased significantly in both groups ( p < 0.05 ) ; however , this reduction was significantly greater in those who took flaxseed supplementation ( p < 0.05 ) . The significant mean differences were reached in hepatic markers  between flaxseed and control group , respectively : ALT [ −11.12 compared with −3.7 U/L ; P < 0.001 ] , AST [ −8.29 compared with −4 U/L ; p < 0.001 ] , GGT [ −15.7 compared with −2.62 U/L ; p < 0.001 ] , fibrosis score [ −1.26 compared with −0.77 kPa ; p = 0.013 ] and steatosis score [ −47 compared with −15.45 dB/m ; p = 0.022 ] . In conclusion , flaxseed supplementation plus lifestyle modification  is more effective than lifestyle modification alone for NAFLD management
Conclusions Whole flaxseed , but not flaxseed oil and lignan extract , has significant effects on improving glycemic control .
Context The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent .
Objective The present study aim ed to systematic ally review and analyze r and omized controlled trials assessing the effects of flaxseed consumption on glycemic control .