Conclusions The current evidence does not suggest an association between leptin and PCa outcome .
However , there may be an inverse association between adiponectin and the incidence of advanced PCa that should be investigated by further studies .
Background Obesity has been proposed as a risk factor for prostate cancer ( PCa ) .
In obesity , serum levels of the appetite-regulating hormones — leptin , adiponectin , and ghrelin — become deregulated .
Objective To explore whether serum levels of appetite-regulating hormones associate with the incidence of PCa , the incidence of advanced disease , or PCa-specific mortality .
Serum leptin: a marker of prostate cancer irrespective of obesity.
INTRODUCTION High expression of leptin receptors have been observed in the prostate cancer in various clinical studies ; however the association of serum leptin with carcinoma prostate remains unresolved . We studied association , between serum leptin and carcinoma prostate in Asian ( Indian ) population and its association with obesity . MATERIAL AND METHODS 30 prospect i ve cases of cancer prostate and 30 age matched controls were included in this study . Body mass index ( BMI ) was estimated and categorized in 4 groups by WHO criteria . Waist hip ratio ( WHR ) was calculated and divided into three groups .  Serum leptin  was estimated by s and wich ELISA technique ( DRG leptin ELISA kit , Marburg , Germany ) . RESULTS Both the groups were comparable for age , WHR and BMI . Serum leptin was significantly higher in patients with cancer prostate as compared to controls ( median 14.18 ng/ml vs. 1.63 ng/ml ; p < 0.001 ) . The level of leptin was found to have positive correlation with BMI and WHR in controls ( r=0.485 , p=0.007 ; r=0.314 , p=0.091 , respectively ) however , no correlation was observed in patients with cancer prostate ( r=0.071 , p=0.711 ; r=0.067 , p=0.725 , respectively ) . There was no correlation between leptin and PSA . The serum leptin level was not related to the Gleason 's score and stage of the carcinoma . CONCLUSIONS This study shows that Prostate cancer is associated with raised serum leptin which is independent of obesity and serum PSA . It hints the role of leptin in pathogenesis of this tumor . It may not be a surrogate marker of aggressiveness . For validation , further studies including a large patient population is required
Conclusions The current evidence does not suggest an association between leptin and PCa outcome .
However , there may be an inverse association between adiponectin and the incidence of advanced PCa that should be investigated by further studies .
Background Obesity has been proposed as a risk factor for prostate cancer ( PCa ) .
In obesity , serum levels of the appetite-regulating hormones — leptin , adiponectin , and ghrelin — become deregulated .
Objective To explore whether serum levels of appetite-regulating hormones associate with the incidence of PCa , the incidence of advanced disease , or PCa-specific mortality .