Conclusions : International differences in prescriber behaviour may influence , and in turn be influenced by , the conduct of clinical trials .
Objective : International differences are thought to exist in dosages used by clinicians treating mood disorders .
This study examined international dosage differences in antidepressant clinical trials , using a data base formed and maintained as a component of a Cochrane review of comparative clinical trials of fluoxetine .
Fluoxetine vs. clomipramine in depressed patients: a controlled multicentre trial.
A sample of 120 patients , all of whom met DSM-III criteria for major unipolar depressive disorder , were r and omly allocated to two treatment groups . Sixty patients were treated with fluoxetine and 60 with clomipramine during a 6-week period . No significant difference was found in antidepressant efficacy , with improvement occurring on both drugs . Important differences were found in the side-effects profile of each group , their incidence being significantly lower and tending to disappear during the course of treatment in the group of patients treated with fluoxetine
Conclusions : International differences in prescriber behaviour may influence , and in turn be influenced by , the conduct of clinical trials .
Objective : International differences are thought to exist in dosages used by clinicians treating mood disorders .
This study examined international dosage differences in antidepressant clinical trials , using a data base formed and maintained as a component of a Cochrane review of comparative clinical trials of fluoxetine .