All 6 studies that investigated bone mineralization had significant findings ; however , due to varying method ologies , the impact of vitamin D on bone mineralization was inconclusive .
SIGNIFICANCE Vitamin D does appear to have some benefit to bone health in adults with epilepsy , and therefore supplementation could potentially be a requisite to using some AEDs .
OBJECTIVE Several antiepileptic drugs ( AEDs ) have been associated with a detrimental effect on bone health through a reduction in serum vitamin D. Subsequently , several studies have investigated the effect of vitamin D supplementation in persons with epilepsy being treated with AEDs .
The present systematic review of published literature was conducted to determine the effect of vitamin D intervention on bone health in adults with epilepsy .
Influence of vitamin D administration on bone ultrasound measurements in patients on anticonvulsant therapy.
BACKGROUND The objective of the study was to evaluate bone mass status ( as measured by bone ultrasound ) in patients on anticonvulsant therapy  , and the influence that Vitamin D administration exerts over it . MATERIAL S AND METHODS We measured and compared the basal serum levels of 25(OH)D3 , parathyroid hormone ( PTH ) , and phalangeal bone ultrasound ( Ad-SOS ) , in 30 adult patients who were taking anticonvulsant drugs , with a control group of similar age and sex . We then gave the patients a large oral dose of 3 mg ( 120.000 UI ) of 25(OH)D3 , and repeated the measurements after one month . RESULTS Basal 25(OH)D3 and Ad-SOS values were significantly lower , and PTH values significantly higher ( P < 0.0001 in all ) , in the patient group . The low Ad-SOS values for the patients were independent of the treatment , but directly related to basal 25(OH)D3 levels ( r = 0.45 , P<0.01 ) . There was a negative association between PTH and 25(OH)D3 ( r = -0.64 , P<0.0001 ) , and no correlation between PTH y Ad-SOS ( r = -0.20 , p NS ) . After ingestion of the large dose of the vitamin D , the patient group registered a significant ( P<0.0001 ) increase in 25(OH)D3 levels , their Ad-SOS values increased ( P<0.0001 ) nearly to the mean basal value of the control group , and PTH decreased significantly ( P<0.0001 ) . CONCLUSIONS These findings justify the need to assure adequate vitamin D intake in patients being treated with anticonvulsants , independently of the treatment , age , sex , and activity status , in order to prevent osteomalacia
All 6 studies that investigated bone mineralization had significant findings ; however , due to varying method ologies , the impact of vitamin D on bone mineralization was inconclusive .
SIGNIFICANCE Vitamin D does appear to have some benefit to bone health in adults with epilepsy , and therefore supplementation could potentially be a requisite to using some AEDs .
OBJECTIVE Several antiepileptic drugs ( AEDs ) have been associated with a detrimental effect on bone health through a reduction in serum vitamin D. Subsequently , several studies have investigated the effect of vitamin D supplementation in persons with epilepsy being treated with AEDs .
The present systematic review of published literature was conducted to determine the effect of vitamin D intervention on bone health in adults with epilepsy .