Consistent with our previous review , several domains of GA are associated with adverse outcomes .
BACKGROUND Our previous systematic review of geriatric assessment ( GA ) in oncology included a literature search up to November 2010 .
However , the quickly evolving field warranted an up date .
Aims of this review : ( i ) provide an overview of all GA instruments developed and /or in use in the oncology setting ; ( ii ) evaluate effectiveness of GA in predicting/modifying outcomes ( e.g. treatment decision impact , treatment toxicity , mortality , use of care ) .
Evaluation of efficacy and safety of FOLFIRI for elderly patients with gastric cancer: a first-line phase II study.
OBJECTIVE Current chemotherapy protocol s for gastric cancer present high toxicity . The FOLFIRI regimen has shown promising results with elderly colorectal cancer patients and for gastric cancer patients but this is the first report on elderly gastric cancer patients . DESIGN In this multicenter non-r and omized phase II trial , we administered the FOLFIRI chemotherapy protocol ( irinotecan [ 180 mg/m(2 ) ] , fluorouracil [ 5-FU ] [ 400 mg/m(2 ) ] and folinic acid 400 mg/m(2 ) or 200mg/m(2 ) of l-folinic acid ) to patients aged over 70 years with locally-advanced or metastatic gastric cancer combined with Comprehensive Geriatric Assessment ( CGA ) . Responses were assessed at 2 months . RESULTS Forty-two patients received eight cycles of the FOLFIRI regimen , with 82.5 % of patients showing disease control : 10 patients ( 26 % ) showing objective ( partial or complete ) responses and 23 ( 57.5 % ) showing stable disease . One-year overall survival ( OS ) was 41.5 % [ 95%CI 26.5 - 56.0 ] and one-year progression-free survival ( PFS ) was 31.8 % [ 95%CI 18.4 - 46.1 % ] . We observed 10 Grade 3/4 hematologic toxicities with one febrile neutropenia . CGA data demonstrated that geriatric functions were not altered by treatment and that nutritional status improved over treatment . CONCLUSIONS Results show excellent disease control and relatively high survival rates with limited toxicity similar to younger patients indicating that this regimen should be considered as a possible treatment in advanced gastric cancer of the elderly
Consistent with our previous review , several domains of GA are associated with adverse outcomes .
BACKGROUND Our previous systematic review of geriatric assessment ( GA ) in oncology included a literature search up to November 2010 .
However , the quickly evolving field warranted an up date .
Aims of this review : ( i ) provide an overview of all GA instruments developed and /or in use in the oncology setting ; ( ii ) evaluate effectiveness of GA in predicting/modifying outcomes ( e.g. treatment decision impact , treatment toxicity , mortality , use of care ) .