We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .
Double-blind, placebo-controlled trial of alternate-day furosemide therapy in infants with chronic bronchopulmonary dysplasia.
To test the hypothesis that alternate-day administration of furosemide will result in a sustained improvement in pulmonary function without causing alterations in electrolyte or mineral homeostasis , we conducted a r and omized , double-blind , placebo-controlled study of 11 hospitalized , oxygen-dependent , spontaneously breathing infants with chronic bronchopulmonary dysplasia . Infants were r and omly selected to receive either furosemide , 4 mg/kg in two divided doses on alternate days orally , or placebo for 8 days , followed by crossover to the alternate-therapy for an additional 8-day period . The two study periods were separated by a 48-hour washout period . Dynamic compliance , total pulmonary resistance , the concentration of electrolytes in serum , and the concentrations of calcium and creatinine in urine were measured on nontreatment days . Alternate-day furosemide therapy increased dynamic lung compliance by 76 + /- 112 % and decreased total pulmonary resistance by 20 + /- 39 % , compared with placebo ( both variables p = 0.032 ) . Alternate-day furosemide therapy did not result in increased urine output , electrolyte abnormalities , or increased urinary calcium excretion . We conclude that this simplified treatment regimen may be useful in the management of infants with chronic bronchopulmonary dysplasia . The results support our previous speculation that furosemide improves pulmonary function by mechanisms unrelated to its diuretic properties
We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .