In addition , there was a low level of evidence that hypercaloric fructose and glucose diets have similar effects on liver fat and liver enzymes in healthy adults .
There was insufficient evidence to draw a conclusion for effects of HFCS or sucrose on NAFLD .
Conclusions : On the basis of indirect comparisons across study findings , the apparent association between indexes of liver health ( ie , liver fat , hepatic de novo lipogenesis , alanine aminotransferase , AST , and γ-glutamyl transpeptase ) and fructose or sucrose intake appear to be confounded by excessive energy intake .
Overall , the available evidence is not sufficiently robust to draw conclusions regarding effects of fructose , HFCS , or sucrose consumption on NAFLD
Background : Concerns have been raised about the concurrent temporal trend between simple sugar intakes , especially of fructose or high-fructose corn syrup ( HFCS ) , and rates of nonalcoholic fatty liver disease ( NAFLD ) in the United States .
Objective : We examined the effect of different amounts and forms of dietary fructose on the incidence or prevalence of NAFLD and indexes of liver health in humans .
The influence of diet upon liver function tests and serum lipids in healthy male volunteers resident in a Phase I unit.
AIM To investigate the effect of diet upon liver function tests and serum lipids within the restricted environment of a Phase I unit . METHODS An open r and omized three-way crossover study was design ed with subjects consuming three types of diet . The diets comprised , a balanced normal calorie diet , a high-carbohydrate high-calorie diet and a high-fat high-calorie diet . Each diet was consumed in a r and omized sequence over 8 days with a recovery period of 14 days between periods . The blood concentrations of various laboratory parameters were measured at intervals throughout each dietary period and during the recovery periods . RESULTS Blood transaminase activity and triglyceride concentrations increased significantly whilst subjects consumed a high-carbohydrate high-calorie diet but not when fed either a high-fat high-calorie diet or a balanced normal calorie diet . CONCLUSIONS The rises in transaminases and triglycerides were caused by the carbohydrate content of the diet rather than its calorific value . Sucrose rather than starch was the carbohydrate which caused the rise in transaminases and triglycerides . The importance of controlling diet in Phase I studies is stressed
In addition , there was a low level of evidence that hypercaloric fructose and glucose diets have similar effects on liver fat and liver enzymes in healthy adults .
There was insufficient evidence to draw a conclusion for effects of HFCS or sucrose on NAFLD .
Conclusions : On the basis of indirect comparisons across study findings , the apparent association between indexes of liver health ( ie , liver fat , hepatic de novo lipogenesis , alanine aminotransferase , AST , and γ-glutamyl transpeptase ) and fructose or sucrose intake appear to be confounded by excessive energy intake .
Overall , the available evidence is not sufficiently robust to draw conclusions regarding effects of fructose , HFCS , or sucrose consumption on NAFLD
Background : Concerns have been raised about the concurrent temporal trend between simple sugar intakes , especially of fructose or high-fructose corn syrup ( HFCS ) , and rates of nonalcoholic fatty liver disease ( NAFLD ) in the United States .
Objective : We examined the effect of different amounts and forms of dietary fructose on the incidence or prevalence of NAFLD and indexes of liver health in humans .