Results show that various classes of antidepressants exert improving effects on cognitive function across several cognitive domains .
Specifically , studies suggest that SSRIs , the SSRE tianeptine , the SNRI duloxetine , vortioxetine and other antidepressants such as bupropion and moclobemide may exert certain improving effects on cognitive function in depression , such as in learning and memory and executive function .
The few non-pharmacological studies conducted employing cognitive orientated treatments and cognitive remediation therapy show promising results for the improvement of cognitive impairment in depression .
Cognitive dysfunction is of clinical significance and exerts longst and ing implication on patients ׳ function .
Pharmacological and non-pharmacological treatments of cognitive dysfunction are emerging .
This review evaluates pharmacological and non-pharmacological treatments of cognitive impairment primarily in the domains of memory , attention , processing speed and executive function in clinical depression .
The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients
It has frequently been demonstrated that acute tryptophan depletion ( ATD ) induces a transient depressed mood in some patients who are in remission from depression . However , the effects of ATD on cognitive processes in remitted depressed patients have not been investigated . The aim of the present study was to investigate the effects of different extents of depletion on mood and cognitive tasks involving neutral and emotional stimuli . Twenty patients in remission or in partial remission from depression received ATD in a double-blind , crossover design . Mood was assessed at both sessions before , at + 6.5 h and + 24 h afterdepletion . Cognitive assessment in both sessions started at + 4.75 h , and also before and after the whole procedure . The ATD mixtures induced the expected reductions of plasma tryptophan levels . High-dose ATD induced a depressive response in a sub sample of patients and impaired theprocessing of positive information independent of mood change . Attention for neutral stimuli ( Stroop interference ) improved in a dose-dependent manner . ATD may affect mood and cognition via different pathways : one implicated in mood regulation and the processing ofemotional information , and one for the processing of neutral information . The first pathway may be more important for discriminating vulnerability to impaired serotonin function . The comparison of the effects of high-dose and low-dose ATD is useful for those studies aim ing to investigate the relationships among 5-HT , mood and cognition
Results show that various classes of antidepressants exert improving effects on cognitive function across several cognitive domains .
Specifically , studies suggest that SSRIs , the SSRE tianeptine , the SNRI duloxetine , vortioxetine and other antidepressants such as bupropion and moclobemide may exert certain improving effects on cognitive function in depression , such as in learning and memory and executive function .
The few non-pharmacological studies conducted employing cognitive orientated treatments and cognitive remediation therapy show promising results for the improvement of cognitive impairment in depression .
Cognitive dysfunction is of clinical significance and exerts longst and ing implication on patients ׳ function .
Pharmacological and non-pharmacological treatments of cognitive dysfunction are emerging .
This review evaluates pharmacological and non-pharmacological treatments of cognitive impairment primarily in the domains of memory , attention , processing speed and executive function in clinical depression .