The findings suggest that pro-/synbiotic supplementation may improve glucose homeostasis parameters , hormonal , and inflammatory indices in women with PCOS
This study aim ed to systematic ally review r and omized clinical trials ( RCTs ) to clarify the effects of pro-/synbiotic supplementation on anthropometric and biochemical measurements in women with polycystic ovary syndrome ( PCOS ) .
Effect of synbiotic pomegranate juice on glycemic, sex hormone profile and anthropometric indices in PCOS: A randomized, triple blind, controlled trial.
BACKGROUND AND AIMS Polycystic Ovarian Syndrome is a common reproductive , endocrine , and metabolic disease in women .  Pomegranate juice , known as a rich source of phytochemicals with high antioxidant activity , enriched with probiotic may improve PCOS . METHODS AND RESULTS A r and omized , controlled , triple-blinded , parallel trial study was performed in PCOS patients ( n = 92 ) . Three treatment groups ( 23 patients each ) received 2 L of synbiotic pomegranate juice ( SPJ ) , pomegranate juice ( PJ ) , and synbiotic beverage ( SB ) weekly . The control group ( 23 patients ) received 2 L of placebo beverage weekly . Primary outcome was any change in insulin resistance and secondary outcomes were fasting blood sugar ( FBS ) , insulin sensitivity , testosterone , luteinizing hormone ( LH ) , follicle stimulating hormone ( FSH ) , body mass index ( BMI ) , waist and hip circumference , from baseline to the end of the trial . At the end of the study , 86 patients were analyzed . There was significant change in insulin resistance in the SPJ and SB groups . Insulin sensitivity increased significantly in the SPJ and SB groups . Insulin also changed significantly in the SPJ and SB groups . BMI , weight and waist circumference decreased significantly in the SPJ and SB groups . Testosterone level also decreased significantly in the SPJ and SB groups . There was no significant change in FPG , LH and FSH in any of the groups . CONCLUSION SPJ in the form of a new beverage can improve insulin resistance , insulin , testosterone level , BMI , weight and waist circumference in PCOS . This trial was registered in Iranian Registry of Clinical Trials , with number : 25272
The findings suggest that pro-/synbiotic supplementation may improve glucose homeostasis parameters , hormonal , and inflammatory indices in women with PCOS
This study aim ed to systematic ally review r and omized clinical trials ( RCTs ) to clarify the effects of pro-/synbiotic supplementation on anthropometric and biochemical measurements in women with polycystic ovary syndrome ( PCOS ) .