In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .
A clinical study evaluating the treatment of supra-alveolar-type defects with access flap surgery with and without an enamel matrix protein derivative: a pilot study.
AIM There is evidence that regenerative treatment of intra-bony and m and ibular class II furcation defects with access flap and an application of an enamel matrix protein derivative ( EMD ) can result in a clinical benefit compared with access flap alone . The aim of this pilot study was to check if the results of access flap surgery in suprabony defects are improved by additional application of EMD . MATERIAL AND METHODS Thirty-nine adult subjects with supra-alveolar-type defects were r and omly assigned to a test ( n=25 ) and a control group ( n=14 ) . Seventy teeth were treated with EMD ; 28 teeth were treated by access flap .  Probing depth ( PD ) , clinical attachment level and bleeding on probing were evaluated at baseline and after 12 months . RESULTS PD of the operated teeth was improved in both groups ( p<0.001 to p=0.041 ) but always better in the test group . The attachment gain was 2.72+/-1.80 mm at sites with an initial PD > or=7 mm in the test group and 0.78+/-0.62 mm in the control group ( p=0.004 ) . In the test group the mean attachment gain was 0.97+/-0.92 mm ( p<0.001 ) ; the mean reduction of PD was 1.55+/-0.90 mm ( p<0.001 ) . CONCLUSIONS The data suggest a significant clinical benefit of supplementary application of EMD during surgical treatment of periodontitis of supra-alveolar pockets , especially in deeper pockets
In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .