RESULT ( S ) For infants , studies on psychomotor development showed no deficits , but few investigated cognitive or behavioral development .
Studies on toddlers generally reported normal cognitive , behavioral , socio-emotional , and psychomotor development .
For children in middle childhood , development seems comparable in children born after assisted reproduction and controls , although fewer studies have been conducted with follow-up to this age .
( S ) It may tentatively be concluded that the neurodevelopment of children born after  fertility treatment  is overall comparable to that in children born after spontaneous conception
OBJECTIVE To systematic ally review the existing literature on neurodevelopmental outcomes in children born after medically assisted reproduction  compared with those of children born after spontaneous conception .
Health of Children Born as a Result of In Vitro Fertilization
OBJECTIVE . The purpose of this study was to use nationwide registries to examine the health of children up to 4 years of age who were born as a result of in vitro fertilization . METHODS . Children born after in vitro fertilization ( N = 4559 ) from 1996 to 1999 were monitored until 2003 . Two control groups were selected from the Finnish Medical Birth Register as follows : all other children ( excluding children born after ovulation induction ) from the same period ( N = 190398 , for study of perinatal health and hospitalizations ) and a r and om sample of those children ( n = 26877 , for study of health-related benefits ) . Mortality rates and odds ratios for perinatal outcomes , hospitalizations , health-related benefits , and long-term medication use were calculated . RESULTS . Although the health of most in vitro fertilization children was good , such children had more health problems than other children . A total of 35.7 % of in vitro fertilization children and 2.2 % of control children were multiple births , and the health of multiple births was worse than that of singletons . Perinatal outcomes of in vitro fertilization children were worse and hospital episodes were more common than among control children . Risks for cerebral palsy and psychological and developmental disorders were increased . Among in vitro fertilization singletons , worse results for perinatal outcomes and hospitalizations , but no increased risk for specific diseases , were found . The health of in vitro fertilization multiple births was comparable to the health of control multiple births . CONCLUSIONS . Reducing the number of transferred embryos would improve the health of in vitro fertilization children . Additional studies are needed to explain the poorer health of in vitro fertilization singletons , as well as follow-up studies to examine the health of in vitro fertilization children from 4 years onward
RESULT ( S ) For infants , studies on psychomotor development showed no deficits , but few investigated cognitive or behavioral development .
Studies on toddlers generally reported normal cognitive , behavioral , socio-emotional , and psychomotor development .
For children in middle childhood , development seems comparable in children born after assisted reproduction and controls , although fewer studies have been conducted with follow-up to this age .
( S ) It may tentatively be concluded that the neurodevelopment of children born after  fertility treatment  is overall comparable to that in children born after spontaneous conception
OBJECTIVE To systematic ally review the existing literature on neurodevelopmental outcomes in children born after medically assisted reproduction  compared with those of children born after spontaneous conception .