The findings support the effects of BAs on satiety , lipid and cholesterol metabolism , incretins and glucose homoeostasis , energy metabolism , gut microbiota and endoplasmic reticulum stress following bariatric surgery .
Many of these metabolic effects are modulated through the BA receptors FXR and TGR5 .
We also explore a possible link between BAs and carcinogenesis following bariatric surgery .
Conclusions : Overall there is good evidence to support the role of BAs in the metabolic effects of bariatric surgery through the above mechanisms .
BAs could serve as a novel therapeutic pharmacological target for the treatment of obesity and its associated co-morbidities
Background : Bariatric surgery is currently the most efficacious treatment for obesity and its associated metabolic co-morbidities , such as diabetes .
The metabolic improvements occur through both weight-dependent and weight-independent mechanisms .
Bile acids ( BAs ) have emerged as key signalling molecules that have a central role in modulating many of the physiological effects seen after bariatric surgery .
This systematic review assesses the evidence from both human and animal studies for the role of BAs in reducing the metabolic complications of obesity following bariatric surgery .
Diet-induced thermogenesis and respiratory quotient after Roux-en-Y gastric bypass surgery: a prospective study.
BACKGROUND Studies in humans and other animals have shown that Roux-en-Y gastric bypass ( RYGB ) leads to increased energy expenditure ( EE ) . We analyzed several components of EE , such as the respiratory quotient ( RQ ) , resting metabolic rate ( RMR ) , and diet-induced thermogenesis ( DIT ) among patients before and after RYGB . METHODS In this prospect i ve clinical study , RMR , DIT , and RQ were measured by indirect calorimetry ( IC ) in the same patients before and 12 months after RYGB  ( the preoperative and postoperative time points , respectively ) . Postpr and ial RQ and DIT were measured after patients consumed a st and ard ~270 kcal meal ( 62 % carbohydrates , 12 % proteins , and 26 % lipids ) . RESULTS The population studied consisted of 13 patients ( mean age 40.8 ± 6.7 years , 85 % female).At the postoperative ( postop ) time point , patients showed higher weight-adjusted RMR compared with the preoperative ( preop ) time point ( P<.01 ) . The absolute and weight-adjusted metabolic rates 20 minutes after the meal were increased postoperatively ( P<.0001 ) but not preoperatively ( P = 0.2962 ) ( DIT ) ; this increase in RQ was significantly higher in the postop than in the preop time point . CONCLUSION The observed patients showed increased EE , DIT , and RQ after RYGB surgery . These data may serve as important physiologic factors contributing to the loss and maintenance of weight after RYGB
The findings support the effects of BAs on satiety , lipid and cholesterol metabolism , incretins and glucose homoeostasis , energy metabolism , gut microbiota and endoplasmic reticulum stress following bariatric surgery .
Many of these metabolic effects are modulated through the BA receptors FXR and TGR5 .
We also explore a possible link between BAs and carcinogenesis following bariatric surgery .
Conclusions : Overall there is good evidence to support the role of BAs in the metabolic effects of bariatric surgery through the above mechanisms .
BAs could serve as a novel therapeutic pharmacological target for the treatment of obesity and its associated co-morbidities
Background : Bariatric surgery is currently the most efficacious treatment for obesity and its associated metabolic co-morbidities , such as diabetes .
The metabolic improvements occur through both weight-dependent and weight-independent mechanisms .
Bile acids ( BAs ) have emerged as key signalling molecules that have a central role in modulating many of the physiological effects seen after bariatric surgery .
This systematic review assesses the evidence from both human and animal studies for the role of BAs in reducing the metabolic complications of obesity following bariatric surgery .