Conclusion This meta- analysis supports the potential use of microbial therapies in the treatment of NAFLD and sheds light on their potential mode of action .
Context Nonalcoholic fatty liver disease ( NAFLD ) is a highly prevalent and underdiagnosed comorbidity of many chronic diseases that is associated with altered intestinal bacterial communities .
This association has prompted research into alternative treatments aim ed at modulating intestinal microbiota .
Given the novelty of these treatments , scarce evidence regarding their effectiveness in clinical population s exists .
Objective This meta- analysis sought to systemically review and quantitatively synthesize evidence on prebiotic , probiotic , and synbiotic therapies for patients with NAFLD in r and omized controlled trials .
Effects of xylooligosaccharides in type 2 diabetes mellitus.
The purpose of this study was to evaluate the effect of xylooligosaccharide ( XOS ) on the blood sugar , lipids and oxidative status in type 2 diabetes mellitus ( DM ) . A total of 26 outpatient subjects of Taichung Veterans General Hospital , Taiwan , with HbA1c levels between 7.0 and 10.0 % and triglyceride < 400 mg/dL were enrolled in the present study . Subjects were supplemented with 4 g/d XOS ( n=12 ) or a placebo ( n=14 ) for 8 wk in a r and omized double-blind clinical design . The results showed that the anthropometric values and nutrient intakes did not change during the experimental period . XOS supplementation not only reduced the glucose , HbA1c and fructosamine concentrations , but also decreased the levels of total cholesterol , low density lipoprotein ( LDL ) cholesterol , oxidized low density lipoprotein ( ox-LDL ) and apolipoprotein B. The activity of catalase of the erythrocyte sample decreased in the XOS group , but not the activities of superoxide dismutase and glutathione peroxidase . In conclusion , the dietary supplementation with XOS for 8 wk was effective in improving the blood sugar and lipids in type 2 diabetes , indicating that XOS-containing diets might be beneficial to DM subjects
Conclusion This meta- analysis supports the potential use of microbial therapies in the treatment of NAFLD and sheds light on their potential mode of action .
Context Nonalcoholic fatty liver disease ( NAFLD ) is a highly prevalent and underdiagnosed comorbidity of many chronic diseases that is associated with altered intestinal bacterial communities .
This association has prompted research into alternative treatments aim ed at modulating intestinal microbiota .
Given the novelty of these treatments , scarce evidence regarding their effectiveness in clinical population s exists .
Objective This meta- analysis sought to systemically review and quantitatively synthesize evidence on prebiotic , probiotic , and synbiotic therapies for patients with NAFLD in r and omized controlled trials .