In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Association between serum fructosamine and mortality in elderly women: the study of osteoporotic fractures.
Serum fructosamine levels can be used to estimate long-term serum glucose values and can be measured in frozen serum . The authors examined whether fructosamine levels were associated with mortality in a cohort of 9,704 white women ( > or = 65 years of age ) recruited from September 1986 to October 1988 at four clinical centers in the United States . A r and om sample of women who had died during a mean of 6 years of follow-up ( n = 55 ) was compared with r and omly  selected controls  ( n = 276 , 54 of whom had died ) .  Fructosamine assays  were performed blinded to vital status . Hazard ratios with 95 % confidence intervals were adjusted for age , clinical center , smoking , hypertension , and serum albumin and cholesterol levels . Each st and ard deviation ( 46 micromol ) increase in fructosamine level was associated with a 1.3-fold ( 95 % confidence interval ( CI ) 1.0 - 1.6 , p = 0.04 ) increased rate of all-cause mortality , including a 1.5-fold ( 95 % CI 1.0 - 2.1 , p = 0.03 ) increase in cardiovascular disease mortality . Elevated fructosamine levels ( > 285 micromol/liter ) were associated with a 4.3-fold ( 95 % CI 1.6 - 12 , p = 0.004 ) increased rate of cardiovascular mortality ; in women without a history of diabetes , the hazard ratio was 4.6 ( 95 % CI 1.3 - 16 , p = 0.02 ) . Fructosamine level , or another indicator of glycemia , should be included when the risk of cardiovascular disease among older patients is evaluated
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .