Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults , results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters .
This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect
This systematic review aims to evaluate r and omised controlled trials ( RCTs ) investigating the effect of vitamin D supplementation on  endothelial function and inflammation in adults .
Effect of estrogen and progesterone on the expression of 1, 25-dihydroxyvitamin D receptors mRNA in the liver of ovariectomized rats.
OBJECTIVE To study the effect of estrogen and progesterone on the expression of dihydroxyvitamin D receptor ( VDR ) mRNA in the liver of ovariectomized rats . METHODS Twenty-five adult female SD rats were r and omly divided , with equal numbers , into sham-operated group ( sham ) , ovariectomized group ( OVX ) , ovariectomized group with estrogen treatment ( OVX+E ) , ovariectomized group with progesterone treatment ( OVX+P ) and ovariectomized group with both estrogen and progesterone treatment ( OVX+E+P ) . After 3 months and a half of feeding , all animals were killed to assess VDR mRNA by way of reverse transcriptase-PCR ( RT-PCR ) . RESULTS RT-PCR revealed marked increase in the b and intensity corresponding to VDR mRNA product in Sham , OVX+E , and OVX+E+P groups . CONCLUSION Estrogen may increase the transcription level of VDR gene in the liver of ovariectomized rats
Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults , results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters .
This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect
This systematic review aims to evaluate r and omised controlled trials ( RCTs ) investigating the effect of vitamin D supplementation on  endothelial function and inflammation in adults .