There was no advantage of regimens lasting > 48 h post-operation .
In the comparison of glycopeptides versus β-lactams , an advantage of glycopeptides was observed when comparators were given for similar duration and for β-lactams when given for a longer duration than the glycopeptides .
There was no significant advantage of high antibiotic dosing .
Evidence supports second- or third-generation cephalosporins for cardiac surgery prophylaxis and points at a possible advantage of prophylaxis prolongation up to 48 h post-operatively
BACKGROUND Antibiotic prophylaxis is recommended in cardiac surgery .
Current debate concerns the type of antibiotic(s ) , dosing and the duration of prophylaxis .
Comparative study of prophylactic antibiotics in cardiac surgery. Clindamycin versus cephalothin.
A r and omized , prospect i ve study of the relative effectiveness of clindamycin versus cephalothin was performed in 263 adult patients having cardiac surgery from September , 1977 , to August , 1978 . There were no statistically significant differences in frequency of postoperative infections in these two antibiotic groups . Wound infection developed in 6.5 percent of the cephalothin group and 3.2 percent of the clindamycin group . Urinary tract infection developed in 5.6 percent of the clindamycin group and 2.1 percent of the cephalothin group . Four bacteremic episodes occurred in the clindamycin-treated patients , and one episode of bacteremia occurred in a cephalothin-treated patient . No cases of endocarditis occurred during the study . Clindamycin deserved consideration as an alternative prophylactic agent to cephalothin for cardiac surgery
There was no advantage of regimens lasting > 48 h post-operation .
In the comparison of glycopeptides versus β-lactams , an advantage of glycopeptides was observed when comparators were given for similar duration and for β-lactams when given for a longer duration than the glycopeptides .
There was no significant advantage of high antibiotic dosing .
Evidence supports second- or third-generation cephalosporins for cardiac surgery prophylaxis and points at a possible advantage of prophylaxis prolongation up to 48 h post-operatively
BACKGROUND Antibiotic prophylaxis is recommended in cardiac surgery .
Current debate concerns the type of antibiotic(s ) , dosing and the duration of prophylaxis .