RESULTS Following an extensive review of selected studies from the 201 articles , the studies indicate that each of the psychotropic medications review ed impact alpha , beta , delta and theta waves independently and differently from each other .
Additionally , certain medications , particularly haloperidol and valproic acid , have dissimilar results exemplified in all waveforms .
OBJECTIVES It is known that psychotropic medications have an impact on the readings found in Electroencephalogram ( EEG ) .
In the field of psychiatry , there are several psychotropics utilized by clinicians .
This review seeks to investigate all the available data for psychotropic drugs and their impact on EEG changes .
Effects of gabapentin and carbamazepine on the EEG and cognition in healthy volunteers.
PURPOSE Antiepileptic drug ( AED ) therapy can be associated with neurotoxic side effects including cognitive dysfunction . Objective methods for detection of neurotoxicity in individual patients would be useful . We studied the effects of gabapentin ( GBP ) and carbamazepine ( CBZ ) on neurophysiologic and cognitive/behavioral measures in healthy volunteers . METHODS In a 12-week , r and omized , double-blind , parallel-group study of CBZ and GBP in healthy volunteers , 23 subjects completed the protocol . All achieved the target dose of 1,200 mg CBZ or 3,600 mg GBP . A structured EEG for quantitative analysis and a cognitive test battery were administered before AED therapy and again after 12 weeks of therapy . Test-retest differences were compared with those of 72 untreated control subjects . RESULTS Both CBZ and GBP significantly decreased the peak frequency of the posterior ( alpha ) rhythm , with CBZ exerting a greater effect . Ten CBZ and six GBP subjects exceeded the 95 % confidence interval ( CI ) for an individual . Cognitive tests revealed AED vs. control group effects for two of seven measures ( Digit Symbol , Stroop ) and all subjective measures . However , few subjects exceeded the 95 % CI for any objective test . Differences between CBZ and GBP were not significant . Greater EEG slowing was associated with greater subjective neurotoxicity and poorer test-retest performance on a cognitive test summary measure . CONCLUSIONS Prolonged CBZ and GBP therapy induced EEG slowing that correlated with cognitive complaints and often exceeded the confidence interval for individual subjects . Quantitative EEG measures may be useful in the objective determination of AED-related neurotoxicity
RESULTS Following an extensive review of selected studies from the 201 articles , the studies indicate that each of the psychotropic medications review ed impact alpha , beta , delta and theta waves independently and differently from each other .
Additionally , certain medications , particularly haloperidol and valproic acid , have dissimilar results exemplified in all waveforms .
OBJECTIVES It is known that psychotropic medications have an impact on the readings found in Electroencephalogram ( EEG ) .
In the field of psychiatry , there are several psychotropics utilized by clinicians .
This review seeks to investigate all the available data for psychotropic drugs and their impact on EEG changes .