No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .
Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitus
Aim : The aim of the present study was to compare the effects of simvastatin and L-carnitine coadministration versus simvastatin monotherapy on lipid profile , lipoprotein(a ) ( Lp(a ) ) and apoprotein(a ) ( Apo(a ) ) levels in type II diabetic patients . Patients / methods : In this double-blind , r and omized clinical trial , 75 patients were assigned to one of two treatment groups for 4 months . Group A received simvastatin monotherapy ; group B received L-carnitine and simvastatin . The following variables were assessed at baseline , after washout and at 1 , 2 , 3 and 4 months of treatment : body mass index , fasting plasma glucose , glycated hemoglobin , total cholesterol , low-density lipoprotein ( LDL ) cholesterol , high-density lipoprotein ( HDL ) cholesterol , triglycerides , Apolipoprotein A1 , Apo B , lipoprotein(a ) and apoprotein(a ) . Results : At the end of treatment in the carnitine and simvastatin combined group compared with the simvastatin alone group , we observed a significant decrease in glycemia ( p < 0.001 ) , tryglicerides ( p < 0.001 ) , Apo B ( p < 0.05 ) , Lp(a ) ( p < 0.05 ) , apo(a ) ( p < 0.05 ) , while HDL significantly increased ( p < 0.05 ) . Conclusions : The coadministration of carnitine and simvastatin result ed in a significant reduction in Lp(a ) and apo(a ) and may represent a new therapeutic option in reducing plasma Lp(a ) levels , LDL cholesterol and Apo B100
No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .