Although pain was a common criterion for nonresponse and appendectomy , analgesic regimens were poorly described .
BACKGROUND Meta-analyses and a recent guideline acknowledge that conservative management of uncomplicated appendicitis with antibiotics can be successful for patients who wish to avoid surgery .
However , guidance as to specific management does not exist .
Association between Appendectomy and Subsequent Colorectal Cancer Development: An Asian Population Study
Objectives The appendix may modulate colon microbiota and bowel inflammation . We investigated whether appendectomy alters colorectal cancer risk . Methods We identified a cohort of 75979 patients who underwent appendectomy between 1997 and 1999 based on the insurance cl aims of Taiwan . A comparison cohort of 303640 persons without appendectomy was selected r and omly , frequency matched by age , sex , comorbidity and entry year was also selected . We monitored subsequent colorectal cancer development in both cohorts . Results The overall colorectal cancer incidence was 14 % higher in the appendectomy patients than in the comparison cohort ( p < 0.05 ) : the highest incidence was observed for rectal cancer , and the lowest incidence was observed for cancer of the cecum-ascending colon for both cohorts . Men were at higher risk than women . Subjects ≥ 60 years had an HR of 12.8 compared to those < 60 years . The incidence of colorectal cancer was much higher in 1.5 - 3.5 years post appendectomy follow-up than for the comparisons ( HR of 2.13 ) . Patients who received an incidental appendectomy had an HR of 2.90 when compared to the comparisons . Conclusions Results of our study suggest that appendectomy in patients with appendicitis is likely associated with the development of colorectal cancer in the post-surgery period
Although pain was a common criterion for nonresponse and appendectomy , analgesic regimens were poorly described .
BACKGROUND Meta-analyses and a recent guideline acknowledge that conservative management of uncomplicated appendicitis with antibiotics can be successful for patients who wish to avoid surgery .
However , guidance as to specific management does not exist .