No differences were seen in blood lipid levels .
Replacement of LCTs with MCTs in the diet could potentially induce modest reductions in body weight and composition without adversely affecting lipid profiles .
BACKGROUND Medium-chain triglycerides ( MCTs ) may result in negative energy balance and weight loss through increased energy expenditure and lipid oxidation .
However , results from human intervention studies investigating the weight reducing potential of MCTs , have been mixed .
OBJECTIVE To conduct a systematic review and meta- analysis of r and omized controlled trials comparing the effects of MCTs , specifically C8:0 and C10:0 , to long-chain triglycerides ( LCTs )  on weight loss and body composition in adults .
Greater rise in fat oxidation with medium-chain triglyceride consumption relative to long-chain triglyceride is associated with lower initial body weight and greater loss of subcutaneous adipose tissue
OBJECTIVE : Medium-chain triglyceride ( MCT ) consumption has been shown to increase energy expenditure ( EE ) and lead to greater losses of the adipose tissue in animals and humans . The objective of this research was to examine the relationship between body composition and thermogenic responsiveness to MCT treatment . DESIGN : R and omized , crossover , controlled feeding trial , with diets rich in either MCT or long-chain triglyceride ( LCT ) ( as olive oil ) for periods of 4 weeks each . SUBJECTS : A total of 19 healthy overweight men aged ( x±s.e.m . ) 44.5±2.5 y with a body mass index of 27.8±0.5 kg/m2 . MEASUREMENTS : EE and body composition were measured using indirect calorimetry and magnetic resonance imaging , respectively , at the baseline and end point of each feeding period . EE was measured for 30 min before consumption of a st and ard meal and for 5.5 h following the meal . RESULTS : Body weight ( BW ) decreased ( P<0.05 ) by 1.03±0.25 kg with MCT consumption compared to 0.62±0.29 kg with LCT consumption . The difference in average EE  between MCT and LCT consumptions was related to initial BW , such that men with lower initial BW had a greater rise in EE  with MCT consumption relative to LCT on day 28 ( r=−0.472 , P=0.04 ) but not day 2 ( r=−0.368 , P=0.12 ) . Similar results were obtained with fat oxidation on day 28 ( r=−0.553 , P=0.01 ) . The greater rise in fat oxidation  with MCT compared to LCT consumption on day 2 tended to be related to greater loss of BW  after MCT vs LCT consumption ( r=−0.4075 , P=0.08 ) . CONCLUSION : These data suggest that shunting of dietary fat towards oxidation results in diminished fat storage , as reflected by the loss of BW and subcutaneous adipose tissue . Furthermore , MCT consumption may stimulate EE and fat oxidation to a lower extent in men of greater BW compared to men of lower BW , indicative of the lower responsiveness to a rapidly oxidized fat by overweight men
No differences were seen in blood lipid levels .
Replacement of LCTs with MCTs in the diet could potentially induce modest reductions in body weight and composition without adversely affecting lipid profiles .
BACKGROUND Medium-chain triglycerides ( MCTs ) may result in negative energy balance and weight loss through increased energy expenditure and lipid oxidation .
However , results from human intervention studies investigating the weight reducing potential of MCTs , have been mixed .
OBJECTIVE To conduct a systematic review and meta- analysis of r and omized controlled trials comparing the effects of MCTs , specifically C8:0 and C10:0 , to long-chain triglycerides ( LCTs )  on weight loss and body composition in adults .