NComb-induced amelioration of lipid profile was not affected by duration of supplementation nor by baseline lipid levels ; conversely , a greater glucose-lowering effect of NComb was found with higher baseline glucose levels and longer duration s of supplementation .
In conclusion , the present results suggest that NComb supplementation is associated with improvement of lipid and glucose profile .
Short-term beneficial effects of NComb supplementation appear to be maintained in the long term
Dyslipidemia and hyperglycemia are associated with an increased risk of  ischemic cardiovascular disease .
Positive effects of a nutraceutical combination comprising red yeast rice , berberine , policosanol , astaxanthin , coenzyme Q10 and folic acid ( NComb ) on plasma lipid and glucose levels have been reported in some but not all clinical trials .
To address this inconsistency , we tried to estimate the size of lipid- and glucose-lowering effects of NComb through a systematic review and meta- analysis of r and omized controlled trials .
Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia.
BACKGROUND Astaxanthin has been reported to improve dyslipidemia and metabolic syndrome in animals , but such effects in humans are not well known . METHODS Placebo-controlled astaxanthin administration at doses of 0 , 6 , 12 , 18 mg/day for 12 weeks was r and omly allocated to 61 non-obese subjects with fasting serum triglyceride of 120 - 200mg/dl and without diabetes and hypertension , aged 25 - 60 years . RESULTS In before and after tests , body mass index ( BMI ) and LDL-cholesterol were unaffected at all doses , however , triglyceride decreased , while HDL-cholesterol increased significantly . Multiple comparison tests showed that 12 and 18 mg/day doses significantly reduced triglyceride , and 6 and 12 mg doses significantly increased HDL-cholesterol . Serum adiponectin was increased by astaxanthin ( 12 and 18 mg/day ) , and changes of adiponectin correlated positively with HDL-cholesterol changes independent of age and BMI . CONCLUSIONS This first-ever r and omized , placebo-controlled human study suggests that astaxanthin consumption ameliorates triglyceride and HDL-cholesterol in correlation with increased adiponectin in humans
NComb-induced amelioration of lipid profile was not affected by duration of supplementation nor by baseline lipid levels ; conversely , a greater glucose-lowering effect of NComb was found with higher baseline glucose levels and longer duration s of supplementation .
In conclusion , the present results suggest that NComb supplementation is associated with improvement of lipid and glucose profile .
Short-term beneficial effects of NComb supplementation appear to be maintained in the long term
Dyslipidemia and hyperglycemia are associated with an increased risk of  ischemic cardiovascular disease .
Positive effects of a nutraceutical combination comprising red yeast rice , berberine , policosanol , astaxanthin , coenzyme Q10 and folic acid ( NComb ) on plasma lipid and glucose levels have been reported in some but not all clinical trials .
To address this inconsistency , we tried to estimate the size of lipid- and glucose-lowering effects of NComb through a systematic review and meta- analysis of r and omized controlled trials .