Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .
Cis-9, trans- 11 and trans-10, cis-12 conjugated linoleic acid (CLA) do not affect the plasma lipoprotein profile in moderately overweight subjects with LDL phenotype B.
BACKGROUND Results of a pilot study suggested that cis-9 , trans-11 conjugated linoleic acid ( CLA ) improved LDL phenotype in moderately overweight subjects with LDL phenotype B. OBJECTIVE Initiated by the results of this pilot study , we have specifically design ed a study to test the hypothesis that cis-9 , trans-11 conjugated linoleic acid improves LDL phenotype in moderately overweight subjects with LDL phenotype B. Effects on the serum lipid profile , on plasma glucose and insulin concentrations , and on clinical parameters were also examined . DESIGN Volunteers with LDL phenotype B were divided into three groups consuming daily a drinkable dairy product not enriched with CLA ( placebo , n = 34 ) , the same dairy product enriched with 3 g c9 , t11 CLA ( n = 34 ) , or the dairy product enriched with 3 g t10 , c12 CLA ( n = 19 ) for 13 weeks . RESULTS Median changes in the proportions of plasma small dense LDL were -2.0 % in the control group and -0.1 % in the c9 , t11 CLA and t10 , c12 CLA groups ( p = 0.981 for the differences between the groups ) . c9 , t11 CLA or t10 , c12 CLA did also not affect serum concentrations of LDL and HDL cholesterol , and of triacylglycerol , and plasma concentrations of glucose and insulin . CONCLUSIONS In humans with LDL phenotype B , c9 , t11 CLA and t10 , c12 CLA do not beneficially change risk factors for cardiovascular disease or diabetes
Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .