Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .
Brief interpersonal psychotherapy for depressed mothers whose children are receiving psychiatric treatment.
OBJECTIVE Depressed mothers of children with psychiatric illness struggle with both their own psychiatric disorder and the dem and s of caring for ill children . When maternal depression remains untreated , mothers suffer , and psychiatric illness in their offspring is less likely to improve . This r and omized , controlled trial compared the interpersonal psychotherapy for depressed mothers ( IPT-MOMS ) , a nine-session intervention based on st and ard interpersonal psychotherapy , to treatment as usual for depressed mothers with psychiatrically ill offspring . METHOD Forty-seven mothers meeting DSM-IV criteria for major depression were recruited from a pediatric mental health clinic where their school-age children were receiving psychiatric treatment and r and omly assigned to IPT-MOMS  ( N=26 ) or  treatment as usual  ( N=21 ) . Mother-child pairs were assessed at three time points : baseline , 3-month follow-up , and 9-month follow-up . Child treatment was not determined by the study . RESULTS Compared to subjects assigned to treatment as usual , subjects assigned to IPT-MOMS showed significantly lower levels of depression symptoms , as measured by the Hamilton Depression Rating Scale , and higher levels of functioning , as measured by the Global Assessment of Functioning , at 3-month and 9-month follow-ups . Compared to the offspring of mothers receiving treatment as usual , the offspring of mothers assigned to IPT-MOMS showed significantly lower levels of depression as measured by the Children 's Depressive Inventory at the 9-month follow-up . CONCLUSIONS Assignment to IPT-MOMS was associated with reduced levels of maternal symptoms and improved functioning at the 3- and 9-month follow-ups compared to treatment as usual . Maternal improvement preceded improvement in offspring , suggesting that maternal changes may mediate child outcomes
Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .