Intake of a carbohydrate-containing fluid is reported to improve insulin-like growth factor levels , reduce hunger , nausea , and length of stay , and attenuate the decrease in whole-body insulin sensitivity and endogenous glucose release .
Amino acid supplementation is reported to reduce muscle atrophy and accelerate return of functional mobility .
There is limited evidence for nutritional supplementation in THR and TKR pathways ; however , the low risk profile and potential benefits to adjunctive treatment methods , such as exercise programs , suggest nutritional supplements may have a role .
Optimizing nutritional status pre-operatively may help manage the surgical stress response , with a particular benefit for undernourished , frail , or elderly individuals
Nutritional supplements can influence outcomes for individuals undergoing major surgery , particularly in older persons whose functional reserve is limited .
Accelerating recovery from total hip replacement ( THR ) and total knee replacement ( TKR ) may offer significant benefits .
Therefore , we explored the role of nutritional supplements in improving recovery following THR and TKR .
A carbohydrate-rich drink shortly before surgery affected IGF-I bioavailability after a total hip replacement. A double-blind placebo controlled study on 29 patients
Background and aims : In response to surgical stress , the body reacts with a change in metabolism to a catabolic state . This is further aggravated by the fasting state preoperatively . We aim ed to determine the effects on catabolism i.e. , body composition and IGF-I bioavailability as measured by the serum IGF-I/IGFBP-1 ratio , of a carbohydrate rich drink given shortly before surgery . Methods : Twenty-nine patients scheduled for a total hip replacement ( THR ) were r and omized in a double-blind placebo-controlled pilot study to a carbohydrate-rich drink or to placebo pre-operatively . The nutritional supplementation consisted of an iso-osmolar carbohydrate-rich drink ( 12.5 g carbohydrates/100 ml , pH 5.0 ) . Fasting blood sample s were collected before surgery and repeated after 5 days and after 2 months . IGF-I and IGFBP-1 were determined in serum by RIA . Body composition was determined by dual energy X-ray absorptiometry ( DXA ) . Results : Compared with placebo we found a relative increase in IGF-I bioavailability post-operatively after a carbohydrate-rich drink given shortly before surgery . There were no significant long-term differences in the changes in fat or lean body mass between groups , but , in a subgroup with late scheduled surgery , there was a tendency to a difference ( p=0.08 ) of fat loss after 2 months , with less fat loss in those who received another carbohydrate drink close to surgery . The pre-operative intake of a 200–200x2 ml carbohydrate drink was well tolerated and safe . There were no adverse events such as pulmonary aspiration before , during or after operation . Conclusions : A carbohydrate-rich drink given shortly before surgery increases IGF-I bioavailability post-operatively in patients undergoing a THR , but has no significant effects on body composition after 2 months in physically active people . We suggest that , if the operation is postponed for more than four hours on the same day , an additional carbohydrate drink should be given
Intake of a carbohydrate-containing fluid is reported to improve insulin-like growth factor levels , reduce hunger , nausea , and length of stay , and attenuate the decrease in whole-body insulin sensitivity and endogenous glucose release .
Amino acid supplementation is reported to reduce muscle atrophy and accelerate return of functional mobility .
There is limited evidence for nutritional supplementation in THR and TKR pathways ; however , the low risk profile and potential benefits to adjunctive treatment methods , such as exercise programs , suggest nutritional supplements may have a role .
Optimizing nutritional status pre-operatively may help manage the surgical stress response , with a particular benefit for undernourished , frail , or elderly individuals
Nutritional supplements can influence outcomes for individuals undergoing major surgery , particularly in older persons whose functional reserve is limited .
Accelerating recovery from total hip replacement ( THR ) and total knee replacement ( TKR ) may offer significant benefits .
Therefore , we explored the role of nutritional supplements in improving recovery following THR and TKR .