Based on the available evidence , motor evoked potentials at rest were the only biomarker that predicted motor outcome in individuals with severe arm impairment following stroke .
To build an underst and ing of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke , we conducted a pooled individual data systematic review to : 1 ) characterize brain biomarkers ; 2 ) determine relationship(s ) between biomarkers and motor outcome ; and 3 ) establish relationship(s ) between biomarkers and motor recovery .
Plasticity of motor cortex excitability induced by rehabilitation therapy for writing
The mechanisms of rehabilitation-induced  plasticity in the motor system after stroke are not defined . The authors studied seven patients with residual poststroke agraphia , aphasia , and right hemiparesis . After a 40-minute rehabilitation therapy that promoted use of the paretic h and for writing , the authors observed a task-specific increase in recruitment of ipsilateral corticospinal pathways .  Rehabilitation aim ed to increase the use of the paretic h and may induce recruitment of previously silent ipsilateral corticospinal pathways even in poorly recovered poststroke patients
Based on the available evidence , motor evoked potentials at rest were the only biomarker that predicted motor outcome in individuals with severe arm impairment following stroke .
To build an underst and ing of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke , we conducted a pooled individual data systematic review to : 1 ) characterize brain biomarkers ; 2 ) determine relationship(s ) between biomarkers and motor outcome ; and 3 ) establish relationship(s ) between biomarkers and motor recovery .