Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .
Effects of Trifolium pratense on the climacteric and sexual symptoms in postmenopause women.
OBJECTIVE To evaluate the effects of treatment with Trifolium pratense on climacteric symptoms and sexual satisfaction in postmenopausal women . METHODS This is a prospect i ve , r and omized , double-blind , placebo-controlled study . Initially , 120 women aged 45 - 65 years with menopausal symptoms , more than 12-month amenorrhea and no treatment in the past six months were selected . The participants were then divided into two groups : TG – receiving 40 mg Trifolium pratense , 1 capsule/day ; PG – receiving placebo capsules containing lactose ( control ) , 1 capsule/day . The duration of treatment was 12 months . The patients underwent clinical and laboratory evaluation before treatment and at four , eight and 12 months of treatment . The Kupperman Menopausal Index and the Golombok Rust Inventory of Sexual Satisfaction ( GRISS ) were used . At the end of the study , each group comprised 50 patients . RESULTS According to the Kupperman Menopausal Index , there was significant improvement in menopausal symptoms after four months of treatment , especially in relation to hot flashes , when compared to baseline data in both groups . However , no significant differences were observed between groups . There was no improvement in sexual satisfaction after treatment . CONCLUSION A 12-month treatment with a daily dose of 40 mg Trifolium pratense did not yield a significant improvement in menopausal symptoms and sexual satisfaction
Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .