LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Continuation of statin therapy and primary prevention of nonfatal cardiovascular events.
Although the beneficial effect of statins in secondary prevention of cardiac events is well established , their effectiveness in primary prevention is question able when most evidence derives from r and omized controlled trials and not " real-life " data . To evaluate the association between persistent use of statins and risk of acute nonfatal cardiovascular events  in primary prevention patients in community setting s , we retrospectively analyzed a cohort of 171,535 adults 45 to 75 years old with no indication of cardiovascular disease who began statin therapy from 1998 to 2009 in a large health maintenance organization in Israel . Persistence with statins was measured by the proportion of days covered with dispensed prescriptions of statins during the follow-up period . Main outcome measurements were occurrence of myocardial infa rct ion or performance of a cardiac revascularization procedure . Incidence of acute cardiovascular events during the follow-up period ( 993,519 person-years ) was 10.22 per 1,000 person-years . Persistence with statins was associated with a lower risk of incident cardiac events ( p for trend < 0.01 ) . The most persistent users ( covered with statins for ≥80 % of their follow-up time ) had a hazard ratio of 0.58 ( 95 % confidence interval 0.55 to 0.62 ) compared to nonpersistent users ( proportion of days covered < 20 % ) . Similar results were found when analyses were limited to patients with > 5 years of follow-up . Treatment with high efficacy statins was associated with a lower risk of cardiac events . In conclusion , our large and unselected community-based study supports the results of r and omized controlled trials regarding the beneficial effect of statins in the primary prevention of acute cardiac events
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .