There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Maternal fish oil supplementation during lactation does not affect blood pressure, pulse wave velocity, or heart rate variability in 2.5-y-old children.
Maternal ( n-3 ) PUFA deficiency is associated with higher  blood pressure ( BP ) later in life in rat offspring , and early intake of ( n-3 ) PUFA in formula-fed infants was shown to modify later BP . BP , heart rate ( HR ) , and heart rate variability ( HRV ) are affected by dietary ( n-3 ) PUFA in adults . In this study , we investigated whether fish oil ( FO ) supplementation of lactating mothers could modify BP , pulse wave velocity ( PWV ) , and HRV in their children after 2 y. Mothers with low fish intake were r and omly assigned to FO or olive oil ( OO ) supplementation for the first 4 mo after delivery . A reference group of mothers with a high habitual fish intake ( HFI ) was also followed . At the follow-up study at 2.5 y of age , BP and PWV were measured , and electrocardiograms were recorded for 0.5 h. FO supplementation significantly increased RBC levels of long-chain ( n-3 ) PUFA of the 4 mo-old children , but at 2.5 y , the FO and OO groups did not differ . BP , PWV , HR , and HRV also did not differ among the groups . However , for all 3 groups , the children 's intake of ( n-3 ) PUFA at 2.5 y was negatively correlated with mean arterial pressure after adjustment for outdoor temperature ( r = -0.245 , P = 0.04 ) . In conclusion , maternal FO supplementation had no overall effect on BP , PWV , or HRV of the children , indicating that ( n-3 ) PUFA intake of Danish mothers may be sufficient in this sense . However , children 's dietary intake of ( n-3 ) PUFA might have a beneficial effect on BP in childhood
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .