In the meta- analysis , tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates .
However , compared with sildenafil , tadalafil significantly improved psychological outcomes .
Furthermore , the patients and their partners preferred tadalafil over sildenafil , and no significant difference was found in the adherence and persistence rates between tadalafil and sildenafil .
Additionally , the myalgia and back pain rates were higher and the flushing rate was lower with tadalafil than with sildenafil .
Conclusion Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients ’ sexual confidence .
Furthermore , patients and their partners prefer tadalafil to sildenafil .
Hence , tadalafil may be a better choice for ED treatment
Aims Erectile dysfunction ( ED ) is a major care problem worldwide .
Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED .
This systematic review and meta- analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED .
Treatment preferences in men with erectile dysfunction: an open label study in Korean men switching from sildenafil citrate to tadalafil.
AIM To evaluate patient preferences for sildenafil citrate or tadalafil ( PDE-5 inhibitors available for the treatment of erectile dysfunction [ ED ] ) and assess potential reasons for these preferences . METHODS This open-label study was conducted on Korean men taking sildenafil , at least 6 weeks prior to study entry , for ED . Following screening , patients continued sildenafil treatment for 4 weeks , then after a 1-week washout period , switched to tadalafil for 8 weeks . Patients then continued with their treatment of choice during an extension phase . Psychosocial factors ( time concern , spontaneity , sexual self-confidence ) were evaluated using Psychological and Interpersonal Relationship Scales ( PAIRS ) , while timing of dose to sexual attempt patterns were assessed from patient diaries . RESULTS The present study enrolled 160 Korean men ( mean age 55 years ) with prior median sildenafil use of 585 days . During the extension phase , 73.7 % of patients elected to take tadalafil , whereas 26.3 % chose sildenafil ( P < 0.001 ) . After switching from sildenafil to tadalafil , mean PAIRS time concern scores decreased from 2.54 to 2.42 ( P = 0.002 ) , with no statistically significant differences observed between the sildenafil and tadalafil assessment phases in sexual spontaneity and self-confidence scores . Sexual attempts made > 4 h to =/ < 36 h post-dose occurred in 4.5 % of patients during the sildenafil assessment phase compared with 17.5 % during the tadalafil assessment phase . CONCLUSION After experiencing both sildenafil and tadalafil , the majority of patients exhibited a preference for tadalafil . This preference might be influenced by psychosocial factors , such as decreased time concerns , and a broader window of opportunity available for sexual activity
In the meta- analysis , tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates .
However , compared with sildenafil , tadalafil significantly improved psychological outcomes .
Furthermore , the patients and their partners preferred tadalafil over sildenafil , and no significant difference was found in the adherence and persistence rates between tadalafil and sildenafil .
Additionally , the myalgia and back pain rates were higher and the flushing rate was lower with tadalafil than with sildenafil .
Conclusion Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients ’ sexual confidence .
Furthermore , patients and their partners prefer tadalafil to sildenafil .
Hence , tadalafil may be a better choice for ED treatment
Aims Erectile dysfunction ( ED ) is a major care problem worldwide .
Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED .
This systematic review and meta- analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED .