There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study.
BACKGROUND Two factors thought to influence the risk of asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids . Although house dust mite allergen avoidance has been used as a preventive strategy in several trials , the effect of omega-3 fatty acid supplementation in the primary prevention of asthma and allergic disease is not known . OBJECTIVE To measure the effects of dietary supplementation with omega-3 fatty acids and house dust mite allergen avoidance in children with a family history of asthma . METHODS A total of 616 children at high risk of asthma were enrolled antenatally in a r and omized controlled trial , and 526 children remained in the trial at age 3 years . The outcomes were symptoms of allergic disease and allergen sensitization . RESULTS There was a significant 10.0 % ( 95 % CI , 3.7 - 16.4 ) reduction in the prevalence of cough in atopic children in the active diet group ( P=.003 ; number needed to treat , 10 ) but a negligible 1.1 % ( 95 % CI , -7.1 to 9.5 ) reduction cough among nonatopic children . There was a 7.2 % ( 95 % CI , 10.11 - 14.3 ) reduction in sensitization to house dust mite in the active allergen avoidance group ( P=.05 ; number needed to treat , 14 ) . No significant differences in wheeze were found with either intervention . CONCLUSION These results suggest that our interventions , design ed to be used in simple public health campaigns , may have a role in preventing the development of allergic sensitization and airways disease in early childhood . This offers the prospect of reducing allergic disease in later life
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .