There were no significant effects of organisational  interventions on lipid profile , HbA1c , medication adherence or recurrent cardiovascular events .
Pooled results indicated that educational interventions were not associated with clear differences in any of the review outcomes .
The estimated effects of organisational interventions were compatible with improvements and no differences in several modifiable risk factors .
BACKGROUND People with stroke or transient ischaemic attack ( TIA ) are at increased risk of future stroke and other cardiovascular events .
Evidence -based strategies for secondary stroke prevention have been established .
However , the implementation of prevention strategies could be improved .
OBJECTIVES To assess the effects of stroke service interventions for implementing secondary stroke prevention strategies on modifiable risk factor control , including patient adherence to prescribed medications , and the occurrence of secondary cardiovascular events .
Possibilities of multifactorial cardiovascular disease prevention in patients aged 75 and older: a randomized controlled trial: Drugs and Evidence Based Medicine in the Elderly (DEBATE) Study.
AIMS The effectiveness of multifactorial cardiovascular disease prevention in patients aged 75 years or older is uncertain , because these patients have often been excluded from trials . The aim of this pre-planned , first-year analysis of the Drugs and Evidence -Based Medicine in the Elderly ( DEBATE ) Study was to determine the feasibility of prevention efforts in elderly cardiovascular patients . METHODS AND RESULTS For DEBATE , home-dwelling individuals aged 75 years and over with cardiovascular diseases ( n=400 , mean age 80 years , 65 % women ) were recruited from the community . These high-risk participants were r and omly assigned to the intervention group  ( n=199 ) where both lifestyle modification and pharmacological cardiovascular treatments are individualized by a geriatrician according to current European guidelines . The control group ( n=201 ) receives the usual care . Interim analysis of the study groups at one year shows that intervention has succeeded in increasing the use of statins , aspirin , beta-blockers , and ACE inhibitors  , and decreasing serum cholesterol ( p<0.0001 ) , LDL-cholesterol ( p<0.0001 ) , and hsCRP ( p=0.04 ) . Body mass index , blood pressure , and blood glucose were similar at one year in both groups . No safety problems or adverse effects on health-related quality of life were observed and compliance was good . CONCLUSIONS It is possible and safe to institute evidence -based cardiovascular treatments in the 75 + cardiovascular patients in a real life setting , but only serum cholesterol and hsCRP are significantly decreased
There were no significant effects of organisational  interventions on lipid profile , HbA1c , medication adherence or recurrent cardiovascular events .
Pooled results indicated that educational interventions were not associated with clear differences in any of the review outcomes .
The estimated effects of organisational interventions were compatible with improvements and no differences in several modifiable risk factors .
BACKGROUND People with stroke or transient ischaemic attack ( TIA ) are at increased risk of future stroke and other cardiovascular events .
Evidence -based strategies for secondary stroke prevention have been established .
However , the implementation of prevention strategies could be improved .
OBJECTIVES To assess the effects of stroke service interventions for implementing secondary stroke prevention strategies on modifiable risk factor control , including patient adherence to prescribed medications , and the occurrence of secondary cardiovascular events .