These observational studies also showed positive correlations between early recognition of the disorder , stimulant treatment during childhood and favorable long-term outcome in adult ADHD patients .
In conclusion , stimulant therapy of ADHD has long-term beneficial effects and is well tolerated .
Attention-deficit/hyperactivity disorder ( ADHD ) is a common disorder of childhood that often persists into adulthood .
Although stimulant medications are recommended as the first-line treatment for ADHD because of their documented short-term effects in children and adults , less is known about their effects on long-term outcome in adults .
Here we review the long-term efficacy and safety of the stimulant drugs methylpheni date and amphetamine , as well as the related compound atomoxetine .
We performed a systematic review to identify direct and indirect effects of stimulant therapy on long-term outcome in adults .
Long-Term Effectiveness and Safety of Dexmethylphenidate Extended-Release Capsules in Adult ADHD
Objective : This study evaluates dexmethylpheni date extended release ( d-MPH-ER ) in adults with ADHD . Method : Following a 5-week , r and omized , controlled , fixed-dose study of d-MPH-ER 20 to 40 mg/d , 170 adults entered a 6-month open-label extension ( OLE ) to assess long-term safety , with flexible dosing of 20 to 40 mg/d . Exploratory effectiveness outcomes included change from Week 5 on ADHD Rating Scale ( ADHD-RS ) and proportion of responders on Clinical Global Impressions — Improvement ( CGI-I ) scale . Results : 103 patients completed OLE , and effectiveness was evaluable in 102 patients . d-MPH-ER was well tolerated ; the most common adverse events ( > 15 % ) were headache , insomnia , and decreased appetite . Mean improvements in ADHD-RS score were −10.2 for patients switched from placebo to d-MPH-ER ( n = 20 ) and −8.4 for those maintained on d-MPH-ER ( n = 82 ) . Respective CGI-I responder rates were 95.0 % and 95.1 % . Conclusion : Once-daily d-MPH-ER 20 to 40 mg is safe and effective for long-term treatment of adult ADHD . ( J. of Att . Dis . 2009 ; 12(5 ) 449 - 459
These observational studies also showed positive correlations between early recognition of the disorder , stimulant treatment during childhood and favorable long-term outcome in adult ADHD patients .
In conclusion , stimulant therapy of ADHD has long-term beneficial effects and is well tolerated .
Attention-deficit/hyperactivity disorder ( ADHD ) is a common disorder of childhood that often persists into adulthood .
Although stimulant medications are recommended as the first-line treatment for ADHD because of their documented short-term effects in children and adults , less is known about their effects on long-term outcome in adults .
Here we review the long-term efficacy and safety of the stimulant drugs methylpheni date and amphetamine , as well as the related compound atomoxetine .
We performed a systematic review to identify direct and indirect effects of stimulant therapy on long-term outcome in adults .