SAMe was not different from placebo and established antidepressants .
The exception was that compared to imipramine , fewer participants experienced troublesome adverse effects when treated with parenteral SAMe .
BACKGROUND Depression is a recurrent illness with high rates of chronicity , treatment-resistance and significant economic impact .
There is evidence in the literature that S-adenosyl methionine ( SAMe ) , a naturally occurring compound in the human body , has antidepressant efficacy .
This product may be an important addition to the armamentarium of antidepressant agents .
OBJECTIVES To assess the effects of SAMe in comparison with placebo or antidepressants for the treatment of depression in adults .
S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS
Background This study reports on clinical data from an 8-week open-label study of 20 HIV-seropositive individuals , diagnosed with Major Depressive Disorder ( DSM-IV ) , who were treated with SAM-e ( S-Adenosylmethionine ) . SAM-e may be a treatment alternative for the management of depression in a population reluctant to add another " pill " or another set of related side effects to an already complex highly active antiretroviral therapy ( HAART ) regimen . Methods The Hamilton Rating Scale for Depression ( HAM-D ) and the Beck Depression Inventory ( BDI ) were used to assess depressive symptomatology from 1,2,4,6 and 8 weeks after initiation of treatment with SAM-e . Results Data show a significant acute reduction in depressive symptomatology , as measured by both the HAM-D and the BDI instruments . Conclusions SAM-e has a rapid effect evident as soon as week 1 ( p < .001 ) , with progressive decreases in depression symptom rating scores throughout the 8 week study
SAMe was not different from placebo and established antidepressants .
The exception was that compared to imipramine , fewer participants experienced troublesome adverse effects when treated with parenteral SAMe .
BACKGROUND Depression is a recurrent illness with high rates of chronicity , treatment-resistance and significant economic impact .
There is evidence in the literature that S-adenosyl methionine ( SAMe ) , a naturally occurring compound in the human body , has antidepressant efficacy .
This product may be an important addition to the armamentarium of antidepressant agents .
OBJECTIVES To assess the effects of SAMe in comparison with placebo or antidepressants for the treatment of depression in adults .