Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Efficacy of oral cholecalciferol on rhododendrol‐induced vitiligo: A blinded randomized clinical trial
Rhododendrol ( RD ) , 4-(4-hydroxyphenyl)-2-butanol , inhibits melanin synthesis and has been used for skin-whitening cosmetic products . RD has been very effective in lightening skin pigmentation , but some persons have developed so-called RD vitiligo , in which vitiligo starts on the face , neck and h and s where topical RD has been applied and even extended over skin areas where RD has not been applied . RD vitiligo lesions in some patients have lasted for years and have been resistant to conventional vitiligo treatments . We examined the effects of cholecalciferol on RD vitiligo in a blinded r and omized clinical trial . Forty-eight female RD vitiligo patients were recruited for the trial and were r and omized into two groups : the vitamin D (VD)-intervention group that received daily 5000 IU cholecalciferol for 5 months and the control group . Three blinded investigators scored vitiligo improvement by comparing photographic images of baseline and at 5-month observation . Serum 25(OH)D3 of RD vitiligo patients was not significantly different from age-matched healthy volunteers . Twenty-two in the VD-intervention group and 23 in the control group completed the 5-month observation . Serum 25(OH)D3 levels were significantly increased after the 5-month VD intervention , while the control group did not change . The improvement scores were significantly higher in the VD-intervention group than the control group . The improvement scores were positively correlated with the serum 25(OH)D3 levels after the 5-month intervention period but not before the treatment . This blinded r and omized clinical trial showed favor in administrating 5000 IU cholecalciferol daily to RD vitiligo patients
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .