Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Atorvastatin effect on high-density lipoprotein-associated paraoxonase activity and oxidative DNA damage
Objective High-density lipoprotein (HDL)-associated antioxidant paraoxonase ( PON ) may reduce low-density lipoprotein ( LDL ) oxidation and prevent atherosclerosis . The aim of this present study was to investigate the effect of the 3-hydroxy-3-methylglutaryl coenzyme A ( HMG-CoA ) reductase inhibitor atorvastatin on hydrogen-peroxide-induced DNA damage by comet assay and the correlation between oxidative DNA damage and antioxidant PON activity . Methods Thirteen type-II/a hyperlipidemic patients were enrolled in the study . We examined the effect of 10 mg/day atorvastatin treatment on lipid levels and the degree of DNA damage in lymphocytes separated from hyperlipidemic patients , nitric oxide ( NO ) , thiobarbituric acid-reactive substances ( TBARS ) , PON levels and activity . Results After 6 months , atorvastatin treatment significantly decreased serum cholesterol and LDL-cholesterol levels . The triglyceride level did not change , and there was no significant change in the HDL cholesterol level . The visual score characteristic to the degree of DNA damage in comet assay was significantly decreased , as well as the TBARS level , while the level of NO was non-significantly increased . PON activity and the PON/HDL ratio were significantly increased after atorvastatin treatment . There was a negative correlation between DNA damage and PON activity , as well as between DNA damage and the PON/HDL ratio before and after atorvastatin treatment . Conclusion These findings show that atorvastatin treatment favorably affected the lipid profile , increasing the activity of HDL-associated PON and decreasing the cytotoxic effect of oxidative stress
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .