There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Relationship between omega3 long-chain polyunsaturated fatty acid status during early infancy and neurodevelopmental status at 1 year of age.
OBJECTIVE To determine the influence of alpha-linolenic acid ( ALA ; 18 : 3omega3 ) intake and , hence , the influence of plasma and /or erythrocyte phospholipid content of docosahexaenoic acid ( DHA ; 22 : 6omega3 ) during early infancy on neurodevelopmental outcome of term infants . METHODS The Bayley Scales of Infant Development ( second edition ) , the Clinical Adaptive Test/ Clinical Linguistic and Auditory Milestone Scale ( CAT/CLAMS ) and the Gross Motor Scale of the Revised Gesell Developmental Inventory were administered at a mean age of 12.26 + /- 0.94 months to 44 normal term infants enrolled in a study evaluating the effects of infant formulas differing only in ALA content ( 0.4 , 1.0 , 1.7 and 3.2 % of total fatty acids ) . RESULTS As reported previously [ Jensen et al. , Lipids 13 ( 1996 ) 107 ; J. Pediatr . 131 ( 1997 ) 200 ] , the group fed the formula with the lowest ALA content had the lowest mean plasma and erythrocyte phospholipid DHA contents at 4 months of age . This group also had the lowest mean score on every neurodevelopmental measure . The difference in mean gross motor developmental quotient of this group versus the group fed the formula with 1.0 % ALA but not of the other groups was statistically significant ( P < 0.05 ) . Across the groups , motor indices correlated positively with each other and with the plasma phospholipid DHA content at 4 months of age ( P=0.02 - 0.03 ) . The CLAMS developmental quotient correlated with the erythrocyte phospholipid content of 20 : 5omega3 ( P < 0.01 ) but not with DHA . CONCLUSIONS These statistically significant correlations suggest that the omega3 fatty acid status during early infancy may be important with respect to neurodevelopmental status at 1 year of age and highlight the need for further studies of this possibility
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .