Furthermore , this therapy could increase the dem and on radiation re sources .
There is no evidence on which to make a recommendation for patients with node-negative tumours that have not penetrated the muscularis propria .
For patients unable to undergo radiation , adjuvant chemotherapy alone may be of benefit , particularly for those with lymph-node metastases .
There is insufficient evidence from r and omized trials to recommend neoadjuvant chemotherapy , or neoadjuvant or adjuvant radiotherapy or immunotherapy , either alone or in combination , outside a clinical trial .
OBJECTIVE To make recommendations on the use of neoadjuvant or adjuvant therapy in addition to surgery in patients with resectable gastric cancer ( T1 - 4 , N1 - 2 , M0 ) .
OPTIONS Neoadjuvant or adjuvant treatments compared with " curative " surgery alone .
OUTCOMES Overall survival , disease-free survival , and adverse effects .
The radiation fields used can possibly damage the left kidney , result ing in hypertension and other renal problems .
Long-term follow-up study of gastric cancer patients treated with surgery and adjuvant chemotherapy with mitomycin C.
A group of 496 cases was used in a controlled trial to study the possible value of mitomycin C as an adjuvant to curative surgery for gastric cancer . Patients assigned to receive the drug were given mitomycin C , 0.8 mg/kg body weight intravenously , twice a week for 5 weeks immediately after surgery . The control group was treated with surgery alone .  Sixty-six patients were excluded from the study because of non-curative surgery . There was no over-all difference in survival and cancer death rates at 5 and 10 years between treated and control groups . However , a survival rate 18.6 % higher at 5 years was observed in the subset of patients who had moderately advanced lymphatic metastases , and a survival rate 26.4 % higher at 5 years was observed in the subset of patients who had involved serosa . The difference in cancer death rate was 14.5 and 24.0 % in each subset , respectively . These significant differences persisted at 10 years . The effect of chemotherapy seemed to result from the successful inhibition of peritoneal dissemination and local recurrence . An adverse effect was observed in patients in the early stages cancer . These results suggest that mitomycin C could be useful as an adjuvant to curative surgery for moderately advanced stages of gastric cancer
Furthermore , this therapy could increase the dem and on radiation re sources .
There is no evidence on which to make a recommendation for patients with node-negative tumours that have not penetrated the muscularis propria .
For patients unable to undergo radiation , adjuvant chemotherapy alone may be of benefit , particularly for those with lymph-node metastases .
There is insufficient evidence from r and omized trials to recommend neoadjuvant chemotherapy , or neoadjuvant or adjuvant radiotherapy or immunotherapy , either alone or in combination , outside a clinical trial .
OBJECTIVE To make recommendations on the use of neoadjuvant or adjuvant therapy in addition to surgery in patients with resectable gastric cancer ( T1 - 4 , N1 - 2 , M0 ) .
OPTIONS Neoadjuvant or adjuvant treatments compared with " curative " surgery alone .
OUTCOMES Overall survival , disease-free survival , and adverse effects .
The radiation fields used can possibly damage the left kidney , result ing in hypertension and other renal problems .