Criterion validity for three of these measures was established in NSCLC but not the reliability or responsiveness .
Background The measurement properties of instruments used to assess functional capacity , physical activity and muscle strength in participants with non-small cell lung cancer ( NSCLC ) have not been systematic ally review ed .
Method Objectives : To identify outcome measures used to assess these outcomes in participants with NSCLC ; and to evaluate , synthesis e and compare the measurement properties of the outcome measures identified .
Performance at preoperative stair-climbing test is associated with prognosis after pulmonary resection in stage I non-small cell lung cancer.
BACKGROUND This investigation evaluated whether the performance at a preoperative symptom-limited stair-climbing test was a prognostic factor in resected pathologic stage I non-small cell lung cancer ( NSCLC ) . METHODS Observational analysis was performed on a prospect i ve data base that included 296 patients who underwent pulmonary lobectomy for pathologic stage T1 N0 or T2 N0 NSCLC ( 2000 to 2008 ) . Patients who received induction chemotherapy were excluded . Survival was calculated by the Kaplan-Meyer method . The log-rank test was used to assess differences in survival between groups . The relationships between survival and baseline and clinical variables were determined by Cox multivariate analyses . RESULTS Median follow-up was 43 months . The best cutoff associated with prognosis was an 18-meter stair climb . Median ( months ) survival and 5-year survival of patients who climbed more than 18 meters were significantly longer than those who climbed less than 18 meters ( 97 vs 74 ; 77 % vs 54 % , p=0.001 ) . Cox regression model ( hazard ratio ) showed that climbing more than 18 meters ( 0.5 ; p=0.003 ) , diffusion capacity of the lung for carbon monoxide ( 0.98 ; p=0.02 ) , and pT stage ( 1.8 ; p=0.02 ) were independent prognostic factors . Patients who climbed less than 18 meters had increased deaths from cancer ( 24 % vs 15 % , p=0.1 ) or other causes ( 19 % vs 9 % , p=0.02 ) . CONCLUSIONS Preoperative cardiopulmonary fitness is a significant prognostic factor in patients after resection for early-stage NSCLC . Interventions aim ed at improving exercise tolerance can be useful to improve long-term prognosis after NSCLC operations
Criterion validity for three of these measures was established in NSCLC but not the reliability or responsiveness .
Background The measurement properties of instruments used to assess functional capacity , physical activity and muscle strength in participants with non-small cell lung cancer ( NSCLC ) have not been systematic ally review ed .
Method Objectives : To identify outcome measures used to assess these outcomes in participants with NSCLC ; and to evaluate , synthesis e and compare the measurement properties of the outcome measures identified .