This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
The effects of vitamin D and omega-3 fatty acid co-supplementation on glycemic control and lipid concentrations in patients with gestational diabetes.
OBJECTIVE This study was performed to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on glucose metabolism and lipid concentrations in gestational diabetes ( GDM ) patients . METHODS This r and omized double-blind placebo-controlled clinical trial was done among 140 GDM patients . Participants were r and omly divided into 4 groups to receive : ( 1 ) 1000 mg omega-3 fatty acids containing 360 mg eicosapentaenoic acid and 240 mg docosahexaenoic acid ( DHA ) twice a day + vitamin D placebo ( n = 35 ) ; ( 2 ) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo ( n = 35 ) ; ( 3 ) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fatty acids twice a day ( n = 35 ) , and ( 4 ) vitamin D placebo + omega-3 fatty acids placebo ( n = 35 ) for 6 weeks . RESULTS After 6 weeks of intervention , patients who received combined vitamin D and omega-3 fatty acids supplements compared with vitamin D , omega-3 fatty acids , and placebo had significantly decreased fasting plasma glucose ( -7.3 ± 7.8 , -6.9 ± 6.6 , -4.0 ± 2.5 , and + 1.0 ± 11.4 mg/dL , respectively , P < .001 ) , serum insulin levels ( -1.9 ± 1.9 , -1.3 ± 6.3 , -0.4 ± 6.3 , and + 2.6 ± 6.5 μIU/mL , respectively , P = .005 ) , homeostatic model of assessment for insulin resistance ( -0.7 ± 0.6 , -0.5 ± 1.4 , -0.2 ± 1.5 , and + 0.6 ± 1.5 , respectively , P < .001 ) and increased quantitative insulin sensitivity check index ( + 0.01 ± 0.01 , + 0.008 ± 0.02 , + 0.002 ± 0.02 , and -0.005 ± 0.02 , respectively , P = .001 ) . In addition , changes in serum triglycerides ( -8.2 ± 41.0 , + 7.6 ± 31.5 , + 3.6 ± 29.9 , and + 20.1 ± 29.6 mg/dL , respectively , P = .006 ) and very low-density lipoprotein cholesterol ( -1.6 ± 8.2 , + 1.5 ± 6.3 , + 0.8 ± 6.0 , and + 4.0 ± 5.9 mg/dL , respectively , P = .006 ) in the vitamin D plus omega-3 fatty acids group were significantly different from the changes in these indicators in the vitamin D , omega-3 fatty acids , and placebo groups . CONCLUSION Overall , vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM patients  had beneficial effects on fasting plasma glucose , serum insulin levels , homeostatic model of assessment for insulin resistance , quantitative insulin sensitivity check index , serum triglycerides , and very low-density lipoprotein cholesterol levels
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .