Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Effect of simvastatin on the lipid profile of hemodialysis patients.
BACKGROUND Simvastatin , a 3-hydroxy 3-methylglutaryl co-enzyme A ( HMG-CoA ) reductase inhibitor , is used widely for treatment of hypercholesterolemia .  Simvastatin may be a suitable treatment for dyslipidemia in hemodialysis ( HD ) patients . However , investigation of the side-effects and safety of long-term administration of simvastatin to HD patients has been limited . In this study , we investigated the effects and safety of simvastatin and its effects on lipoprotein metabolism in hypercholesterolemic patients on HD . METHODS Simvastatin was administered at a dosage of 5 mg/day for 24 weeks to 38 HD patients with high serum total cholesterol ( TC ) levels ( 200 mg/dl ) or low high-density lipoprotein cholesterol ( HDL-C ) levels ( 35 mg/dl ) . Every four weeks , serum lipids , apolipoprotein , lipoprotein ( a ) [ Lp(a ) ] and malondialdehyde ( MDA ) levels were measured . In addition , lipid levels were determined in each lipoprotein fraction separated by ultracentrifugation . RESULTS After 24 weeks of simvastatin administration , TC significantly decreased by 25.7 % , and low-density lipoprotein cholesterol ( LDL-C ) was significantly decreased by 33.6 % . Triglyceride ( TG ) and HDL-C showed no significant changes . Apolipoprotein ( apo ) B significantly decreased by 24.5 % and apo E by 30.0 % . No significant changes were observed in the other apolipoproteins . MDA was also significantly decreased , whereas Lp(a ) was not significantly altered . In the lipoprotein fractions , very LDL cholesterol ( VLDL-C ) , intermediate-density lipoprotein cholesterol ( IDL-C ) , LDL1 cholesterol ( LDL1-C ) , and LDL2 cholesterol ( LDL2-C ) showed significant decreases . No particular side-effects were observed during the 12 months of simvastatin administration . CONCLUSIONS These results suggest that simvastatin appears to be safe and effective in HD patients with hypercholesterolemia
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .