Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .
Efficacy on menopausal neurovegetative symptoms and some plasma lipids blood levels of an herbal product containing isoflavones and other plant extracts.
OBJECTIVES To assess the efficacy of a product containing isoflavones and other plant extracts ( BIO ) on whole menopausal symptomatology and plasma lipids profile . METHODS Multicentre , r and omized , double blind , placebo controlled clinical investigation on 125 menopausal women r and omly assigned to two groups treated for 6 months with placebo or one tablet daily of an herbal product containing 72 mg/dose of isoflavones of different plants origin and other plant extracts ( BIO ) . Primary end-point : Kupperman Menopause Index ( KI ) variations ; secondary end-point : activity on plasma lipids profile and clinical global impression ( CGI ) on efficacy and tolerability by investigators and patients . The usual parametric test ( paired Student t test ) was performed to evaluate the significance . In case of non-applicability of parametric tests , the non-parametric Mann-Whitney U test was used . The differences where considered significant at p<0.05 level . RESULTS At the end of treatment in both groups KI showed a significant decrease ( p<0.001 ) . However , in the BIO group the KI reduction was significantly higher ( p=0.0265 ) than in the placebo group after 4 and 6 months of treatment . In the BIO treated patients the LDL cholesterol showed a borderline but not significant reduction compared to placebo ( p=0.0608 ) and triglyceride ( TG ) a significant ( p=0.0151 ) decrease compared to placebo . The investigator 's and patient 's CGI on BIO group where superior as compared to placebo . Clinical tolerability was good in booth groups . CONCLUSION On the basis of positive effects on KI and lipids profile as well as of good clinical tolerability , BIO can be considered one of the possible alternative therapy for conventional HRT
Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .