Results Insulin resistance indicators were significantly improved after bariatric surgery .
Leptin was also significantly decreased while adiponectin was significantly increased .
Although the level of metabolic hormones changed after bariatric surgery , they were not statistically significant .
Inflammation indicators were significantly decreased .
Significant reduction was also detected in PAI-1 and sICAM-1 .
Conclusions Bariatric surgery is beneficial in morbidly obese patients .
Although treating obesity in a surgical way may cause some complications , the weight loss is generally safe and effective
Background Considering conflicting results on the consequences of all types of obesity surgery , we were to summarize them via a systematic review .
Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles
Background : In obesity , metabolic stress and inflammation in injured tissues could favour enhanced shedding of procoagulant microparticles ( MPs ) . At sites of endothelium injury , the swift recruitment of procoagulant leukocyte-derived MPs enables the initiation of blood coagulation and thrombus growth . Objectives : In obese females , we sought to evaluate the impact of a very low-calorie diet ( VLCD ) on procoagulant MP levels , fibrinolytic status , inflammation and endothelium damage . Methods : Circulating biomarkers of vascular damage , fibrinolytic status , platelet activation and inflammation were measured before , 30 and 90 days after starting a short-term VLCD . MPs were measured by flow cytometry and capture assays . Their procoagulant potential was quantified using functional prothrombinase assays and their cellular origin were determined using flow cytometry ( endothelium , platelet , leukocyte , lymphocyte and erythrocyte-derived MP ) or capture assays . Results : A total of 24 obese females ( 39±10 years ) with a mean body mass index of 35±4 kg m−2 were prospect ively enroled . Procoagulant leukocyte-derived MPs were associated with the waist circumference at baseline ( r=0.534 ; P=0.010 ) and at 90 days follow-up ( r=0.487 ; P=0.021 ) . At 90 days , weight reduction ( −9.8 % ) was associated with a lowering of blood pressure , improvement of metabolic parameters and a significant reduction of plasminogen activator inhibitor-1 ( PAI-1 ) ( −38 % ) , procoagulant platelet-derived MPs ( −43 % ) , leukocyte-derived MPs ( −28 % ) and leptin ( −32 % ) levels . Conclusion : In obese females  , a short-term VLCD results in an overall improvement of the haemostatic balance characterized by the reduction of PAI-levels , diminished release of platelet and leukocyte-derived MPs and a reduction in leptin levels , an adipocyte-derived cytokine
Results Insulin resistance indicators were significantly improved after bariatric surgery .
Leptin was also significantly decreased while adiponectin was significantly increased .
Although the level of metabolic hormones changed after bariatric surgery , they were not statistically significant .
Inflammation indicators were significantly decreased .
Significant reduction was also detected in PAI-1 and sICAM-1 .
Conclusions Bariatric surgery is beneficial in morbidly obese patients .
Although treating obesity in a surgical way may cause some complications , the weight loss is generally safe and effective
Background Considering conflicting results on the consequences of all types of obesity surgery , we were to summarize them via a systematic review .