In the meta- analysis , tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates .
However , compared with sildenafil , tadalafil significantly improved psychological outcomes .
Furthermore , the patients and their partners preferred tadalafil over sildenafil , and no significant difference was found in the adherence and persistence rates between tadalafil and sildenafil .
Additionally , the myalgia and back pain rates were higher and the flushing rate was lower with tadalafil than with sildenafil .
Conclusion Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients ’ sexual confidence .
Furthermore , patients and their partners prefer tadalafil to sildenafil .
Hence , tadalafil may be a better choice for ED treatment
Aims Erectile dysfunction ( ED ) is a major care problem worldwide .
Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED .
This systematic review and meta- analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED .
An analysis of treatment preferences and sexual quality of life outcomes in female partners of Chinese men with erectile dysfunction
The impact of erectile dysfunction is distressing to both males and their female partners , but less attention has been paid to identify female partners′ preferred treatment and sexual quality of life outcomes . The present analysis explores female partners′ treatment preference for erectile dysfunction in Chinese Men . This was a phase 4 , r and omized , open-label , multicenter , crossover study in Chinese men with erectile dysfunction who were naïve to phosphodiesterase type 5 inhibitor treatments . Eligible patients were r and omized to sequential 20-mg tadalafil/100-mg sildenafil or 100-mg sildenafil/20-mg tadalafil for 8 weeks each . Of 418 patients , female partners of 64 patients agreed to enter the study ; of 64 patients who entered the study with female partners , 63 were r and omized , and 62 completed the study . Baseline demographics and disease characteristics were comparable between treatment groups . Significantly more couples preferred tadalafil compared with sildenafil overall ( 75.4 % vs 24.6 % ; P < 0.001 ) , and irrespective of erectile dysfunction severity at baseline ( P ≤ 0.005 ) . Significant improvements in sexual quality of life scores were reported at endpoint ( Visit 8) in male patients and female partners in both tadalafil and sildenafil treatment groups ( P < 0.001 ) . Significantly higher mean changes from baseline were observed for male patients in the tadalafil group compared with the sildenafil group for the erectile function ( P = 0.013 ) and overall satisfaction ( P = 0.019 ) International Index for Erectile Function domains and the spontaneity domain ( P < 0.001 ) of the Psychological and Interpersonal Relationship Scale . No major safety concerns were reported during the study . Though both treatments were effective , safe , and tolerable , more couples preferred tadalafil compared with sildenafil
In the meta- analysis , tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates .
However , compared with sildenafil , tadalafil significantly improved psychological outcomes .
Furthermore , the patients and their partners preferred tadalafil over sildenafil , and no significant difference was found in the adherence and persistence rates between tadalafil and sildenafil .
Additionally , the myalgia and back pain rates were higher and the flushing rate was lower with tadalafil than with sildenafil .
Conclusion Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients ’ sexual confidence .
Furthermore , patients and their partners prefer tadalafil to sildenafil .
Hence , tadalafil may be a better choice for ED treatment
Aims Erectile dysfunction ( ED ) is a major care problem worldwide .
Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED .
This systematic review and meta- analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED .