We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .
Dietary supplementation with marine fish oil improves in vitro small artery endothelial function in hypercholesterolemic patients: a double-blind placebo-controlled study.
BACKGROUND Marine fish oils improve vascular function , but the mechanism of benefit is unclear . We conducted a study to examine the effects of fish oils given to hypercholesterolemic patients on small artery function in vitro . METHODS AND RESULTS In a r and omized , double-blind , placebo-controlled trial , subcutaneous gluteal fat biopsies were taken from 16 hypercholesterolemic patients ( serum total cholesterol , 7.97+/-0.16 mmol/L [ mean+/-SEM ] ) and 12 age- and sex-matched control subjects ( mean cholesterol , 5.11+/-0.34 mmol/L ) . Small arteries were mounted on a wire myograph for isometric tension experiments . Patients and control subjects were r and omized to receive fish oil ( Maxepa 5 capsules BID ) or placebo for 3 months . A second biopsy was taken and the studies were repeated . Relaxation to acetylcholine was significantly improved in the hypercholesterolemic group given Maxepa but not in the placebo group ( mean maximum relaxation before and after , 48+/-6.2 % and 68.83+/-2.19 % , P=.0054 ) . The dysfunction was not restored to control values ( 84.3+/-5.2 % , P=.0002 ) . There was also a smaller but significant impairment in endothelium-independent relaxation provoked by sodium nitroprusside ( P<.01 ) . A good correlation between the increase in eicosapentanoic acid ( n=3 ) in red cell membrane and improvement in relaxation in the hypercholesterolemic group given fish oils was seen ( r=.781 , P<.02 ) . CONCLUSIONS Marine fish oil significantly improved endothelial function in peripheral small arteries in hypercholesterolemia patients . This may provide a mechanism for the beneficial effects of these fatty acids in coronary heart disease
We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .