Pelvic floor exercises are more effective in subjective and objective outcomes with biofeedback or verbal feedback .
Weight loss with diet and exercise , caffeine reduction , 25 - 50 % reduction in fluid intake , and pelvic floor muscle exercises with verbal instruction and or biofeedback were all efficacious .
Botulinum toxin A improves urge incontinence episodes , urgency , frequency , quality of life , nocturia , and urodynamic testing parameters .
Acupuncture  improves quality of life and urodynamic testing parameters .
Extracorporeal magnetic stimulation improves urodynamic parameters .
Mirabegron improves daily incontinence episodes , nocturia , number of daily voids , and urine volume per void , whereas solabegron improves daily incontinence episodes .
Short-term posterior tibial nerve stimulation is more efficacious than pelvic floor muscle training exercises and behavioral therapy for improving : urgency , urinary incontinence episodes , daily voids , volume per void , and overall quality of life .
Sacral neuromodulation is more efficacious than antimuscarinic treatment for subjective improvement of overactive bladder and quality of life .
Transvaginal electrical stimulation demonstrates subjective improvement in overactive bladder symptoms and urodynamic parameters .
Multiple therapies , including physical therapy , behavioral therapy , botulinum toxin A , acupuncture , magnetic stimulation , mirabegron , posterior tibial nerve stimulation , sacral neuromodulation , and transvaginal electrical stimulation , are efficacious in the treatment of overactive bladder
The purpose of the study was to determine the efficacy and safety of nonantimuscarinic treatments for overactive bladder .
Unilateral versus bilateral sacral neuromodulation in patients with chronic voiding dysfunction.
PURPOSE Bilateral sacral nerve neuromodulation has been proposed as a more effective treatment for  chronic voiding dysfunction .  However no comparison with the unilateral approach has been performed . We investigated the possible advantage of bilateral sacral neuromodulation . MATERIAL S AND METHODS In a prospect i ve r and omized crossover trial we investigated 33 patients who underwent bilateral implantation of a temporary test lead . Unilateral and bilateral test stimulation was continued for 4 to 6 days in all patients . Patients were r and omly assigned to start with bilateral or unilateral stimulation . Between the stimulation episodes a 2-day washout interval was scheduled . Voiding diaries were completed at baseline and during the entire stimulation period . Sacral x-rays were taken to confirm lead positioning or possible migration after implantation and at the end of the test stimulation period . After 10 days the temporary leads were removed and voiding diaries were analyzed . RESULTS After stimulation sacral x-ray revealed test lead migration in 8 patients , leaving 12 patients with urge incontinence and 13 with voiding difficulty and urinary retention  available for review . A statistically significant improvement in voiding parameters was seen during the test stimulation period . However no statistically significant improvement was seen due to bilateral stimulation compared to unilateral stimulation . Two patients with urinary retention only started voiding to completion during bilateral stimulation . CONCLUSIONS Bilateral is in general not superior to unilateral sacral neuromodulation . However , in some individuals bilateral stimulation may be more effective in relieving symptoms . Therefore , if unilateral percutaneous nerve evaluation fails , a bilateral test should be considered
Pelvic floor exercises are more effective in subjective and objective outcomes with biofeedback or verbal feedback .
Weight loss with diet and exercise , caffeine reduction , 25 - 50 % reduction in fluid intake , and pelvic floor muscle exercises with verbal instruction and or biofeedback were all efficacious .
Botulinum toxin A improves urge incontinence episodes , urgency , frequency , quality of life , nocturia , and urodynamic testing parameters .
Acupuncture  improves quality of life and urodynamic testing parameters .
Extracorporeal magnetic stimulation improves urodynamic parameters .
Mirabegron improves daily incontinence episodes , nocturia , number of daily voids , and urine volume per void , whereas solabegron improves daily incontinence episodes .
Short-term posterior tibial nerve stimulation is more efficacious than pelvic floor muscle training exercises and behavioral therapy for improving : urgency , urinary incontinence episodes , daily voids , volume per void , and overall quality of life .
Sacral neuromodulation is more efficacious than antimuscarinic treatment for subjective improvement of overactive bladder and quality of life .
Transvaginal electrical stimulation demonstrates subjective improvement in overactive bladder symptoms and urodynamic parameters .
Multiple therapies , including physical therapy , behavioral therapy , botulinum toxin A , acupuncture , magnetic stimulation , mirabegron , posterior tibial nerve stimulation , sacral neuromodulation , and transvaginal electrical stimulation , are efficacious in the treatment of overactive bladder
The purpose of the study was to determine the efficacy and safety of nonantimuscarinic treatments for overactive bladder .