Subgroup analysis for assay type was statistically significant for spontaneous POI only .
Sensitivity analyses of high- quality studies did not change the results , and result ed in a substantial decrease in heterogeneity in spontaneous POI studies .
The current meta- analysis demonstrates that total testosterone concentrations are decreased in women with spontaneous POI or iatrogenic menopause .
BACKGROUND Increasing age and post-menopausal status are associated with decreasing and rogen concentrations in females .
Women with premature loss of ovarian function , such as primary ovarian insufficiency ( POI ) or iatrogenic menopause may be at increased risk for diminished testosterone levels at a relatively young age .
Differentiation between a hypo and rogenic or normo and rogenic state in women with premature loss of ovarian function is problematic due to trueness and precision problems using various testosterone assays .
The current meta- analysis was conducted to evaluate current literature reporting serum total testosterone concentrations under these conditions , including stratification for various testosterone assays .
Impaired endothelial function in young women with premature ovarian failure: normalization with hormone therapy.
Normal menopause is associated with vascular endothelial dysfunction , an early stage of atherosclerosis . The effect of premature ovarian failure ( or premature menopause ) on endothelial function in young women is unknown . Endothelial function was assessed in 18 women with premature ovarian failure before and after 6 months of hormone therapy  and was compared with the endothelial function of 20 age- and body mass index-matched premenopausal women .  Brachial artery diameter was measured both during hyperemia ( an index of endothelium-dependent vasodilation ) and in response to glyceryl trinitrate ( an index of endothelium-independent vaso-dilation ) . Flow-mediated dilation was significantly lower in women with premature ovarian failure at baseline ( increase in brachial artery diameter during hyperemia by 3.06 + /- 4.33 % ) than in control women ( increase by 8.84 + /- 2.15 % ; P < 0.0005 ) . Glyceryl trinitrate-induced vasodilation did not differ between the groups . After hormone therapy for 6 months , flow-mediated dilation was improved in women with premature ovarian failure , increasing by more than 2-fold ( 7.41 + /- 3.86 % ; P < 0.005 compared with pretreatment ) and reaching normal values ( P not significant compared with control women ) . Glyceryl trinitrate-induced vasodilation did not change after treatment in women with premature ovarian failure . Young women with premature ovarian failure have significant vascular endothelial dysfunction . Early onset of endothelial dysfunction associated with sex steroid deficiency may contribute to the increased risk of cardiovascular disease and mortality in young women with premature ovarian failure . Hormone therapy restores endothelial function within 6 months of treatment
Subgroup analysis for assay type was statistically significant for spontaneous POI only .
Sensitivity analyses of high- quality studies did not change the results , and result ed in a substantial decrease in heterogeneity in spontaneous POI studies .
The current meta- analysis demonstrates that total testosterone concentrations are decreased in women with spontaneous POI or iatrogenic menopause .
BACKGROUND Increasing age and post-menopausal status are associated with decreasing and rogen concentrations in females .
Women with premature loss of ovarian function , such as primary ovarian insufficiency ( POI ) or iatrogenic menopause may be at increased risk for diminished testosterone levels at a relatively young age .
Differentiation between a hypo and rogenic or normo and rogenic state in women with premature loss of ovarian function is problematic due to trueness and precision problems using various testosterone assays .
The current meta- analysis was conducted to evaluate current literature reporting serum total testosterone concentrations under these conditions , including stratification for various testosterone assays .