We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
Caesarean section and gastrointestinal symptoms, atopic dermatitis, and sensitisation during the first year of life
Aims : To investigate the effect of caesarean section on gastrointestinal symptoms , atopic dermatitis , and sensitisation to nutritional allergens in infants . Methods : A total of 865 healthy full term neonates with parental history of allergy participating in the prospect i ve German Infant Nutritional Intervention Program ( GINI ) were exclusively breast fed during the first four months of life and had a one year follow up . Data were obtained by follow up visits at age 1 , 4 , 8 , and 12 months , weekly diaries for the first six months , and measurement of total and specific IgE at birth and 12 months . Results : Infants born by  caesarean section  ( 147/865 , 17 % ) had a greater risk of diarrhoea ( ORadj 1.46 , 95 % CI 1.022 to 2.10 ) and sensitisation to food allergens , both in adjusted ( ORadj 2.06 , 95 % CI 1.123 to 3.80 ) and stratified analyses ( by cord blood IgE ) . Caesarean delivery was not associated with colicky pain and atopic dermatitis . Conclusion : Caesarean delivery might be a risk factor for diarrhoea and sensitisation in infants with family history of allergy . Further research in this area seems warranted as choosing caesarean section becomes increasingly popular
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .