Serious adverse events attributable to vitamin D supplementation were rare across all studies .
On the basis of studies review ed to date , the strongest evidence supports further research into adjunctive vitamin D therapy for tuberculosis , influenza , and viral upper respiratory tract illnesses .
OBJECTIVE To review the existing human controlled intervention studies of vitamin D as adjunctive therapy in setting s of infection and provide recommendations for design and implementation of future studies in this field on the basis of the evidence review ed .
Vitamin D administration to tuberculous children and its value.
Our study was done to assess the value of administration of vitamin D to tuberculous children . The study included twenty four newly diagnosed tuberculous children ; eleven males and thirteen females . Their age ranged from one and half to thirteen years . Thirteen patients were extra thoracic type of T.B. , while only seven were intrathoracic and the rest were mixed . They were r and omly divided into two Groups according to the treatment administered : Group A patients were given Rifampicin , Isoniazid and Streptomycin . Group B received in addition vitamin D. After eight weeks therapy , the patients of each group were evaluated regarding clinical , laboratory , and radiological improvement . Vitamin D level is raised after treatment in both Groups A and B , but this rise is not significant . It also showed insignificant difference between the two groups .  Vitamin D level showed very high significant decrease in tuberculous children than matched healthy controls ( non tuberculous children ) . Calcium was significantly elevated after treatment in Group A whereas no significant change was detected in Group B. Phosphorous was highly significantly elevated after treatment in Group A , whereas in Group B it is just significantly elevated . Alkaline phosphatase level in both groups A and B were slightly decreased after treatment . However , this decrease was not significant . Clinical improvement was more evident in Group B patients ( those taking vitamin D ) as compared to Group A patients . The same was noted with X-ray and Sonographic findings . We concluded that vitamin D therapy may be of great value in addition to antituberculous drugs in the treatment of tuberculous children , and its use is highly recommended
Serious adverse events attributable to vitamin D supplementation were rare across all studies .
On the basis of studies review ed to date , the strongest evidence supports further research into adjunctive vitamin D therapy for tuberculosis , influenza , and viral upper respiratory tract illnesses .
OBJECTIVE To review the existing human controlled intervention studies of vitamin D as adjunctive therapy in setting s of infection and provide recommendations for design and implementation of future studies in this field on the basis of the evidence review ed .