Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Topical Delivery of Vitamin D3: A Randomized Controlled Pilot Study
Background and Objective : The purpose of the present study is to explore the assessment if the transdermal delivery of vitamin D is feasible . Methods : In 50 female Medical students , this study was conducted . Age , weight and height was taken , a detailed history and clinical examination was performed . Blood was drawn for 25 Hydroxy Vitamin D3 ( 25OHD ) level . Two women had > 30 ng/mL of 25OHD and was excluded from the study . The participants were divided into two groups of 24 in each arm . All participants equivocally agreed not to change their dietary habits and life style till the study was over . The study group of women were asked to apply ; Top-D ( Aloe Vera based- Vitamin D3 ) ( Patency Pending ) was developed at King Fahd Hospital of the University , AlKhobar with each gram of the Top-D cream delivering 5000 IU of vitamin D3 . The second group used 1 gram of Aloe vera gel . The participants had no knowledge to which group they belong . A second blood sample was taken at the end of 3 months and the data was analyzed . Results : The data of 48 women was available for analysis . The average age was 22.58 ± 1.95 years .  The mean pre-treatment 25OHD in the study group was 12.05 ng/Ml ± 6.54 and post-treatment was 37.95 ng/mL ± 6.43 ( P=0.001 , CI<28.582 ) . In control group pre-treatment 25OHD was 11.4 ng/mL ± 3.97 and post-treatment was 10.58ng/mL ± 3.03 . Conclusions : This r and omized control study shows that vitamin D3 can safely be delivered through the dermal route . This route could be exploited in treating vitamin D deficiency
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .