Some studies suggest that testosterone therapy has additional effects , which include increased bone mineral density and decreased serum high-density lipoprotein ( HDL ) cholesterol .
The clinical sequelae of oestrogen deficiency during menopause are undoubted .
However , the pathophysiological role of testosterone during the menopause is less clear .
Several r and omized , placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women .
Preliminary observations on differing psychological effects of conjugated and esterified estrogen treatments.
During a double-blind comparison of menopausal replacement therapy with estrogen alone compared with estrogen plus methyltestosterone ( meT ) , subjects who had been on conjugated equine estrogen ( CEE ) said they felt better when placed on esterified estrogen ( EE ) . We , therefore , tested whether these estrogen treatments differed in their neuropsychological effects .  Subjects were 34 healthy menopausal respondents to advertisements younger than age 66 who were on CEE at baseline . Each was r and omized into the EE condition , either immediately after baseline or after they first took EE plus added meT for 8 weeks . We compared neuropsychological measures between these two conditions . Data included cognitive performance test results and symptom self-ratings . Multivariate techniques were used to adjust for the effects of treatment order . Compared with prior CEE treatment , EE treatment was associated with significantly improved scores on the Zung Self-Rated Depression Scale and on Switching Attention Test performance . Further investigation is warranted to determine if different forms of estrogen replacement induce different neuropsychological effects
Some studies suggest that testosterone therapy has additional effects , which include increased bone mineral density and decreased serum high-density lipoprotein ( HDL ) cholesterol .
The clinical sequelae of oestrogen deficiency during menopause are undoubted .
However , the pathophysiological role of testosterone during the menopause is less clear .
Several r and omized , placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women .