Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .
Effect of a probiotic preparation (VSL#3) in critically ill patients: A randomized, double-blind, placebo-controlled trial (Pilot Study)
Objective : Reactive oxygen species ( ROS ) are a major contributing factor in diseases pathophysiology in critically ill patients . Oxidative stress usually occurs in critical illnesses , specifically during sepsis , and organ dysfunction . The anti-oxidative properties of probiotics may serve as a defense in intestine and overcome various oxidative stresses . The aim of this trial was to determine the effect of probiotics on inflammation , antioxidant capacity and lipid peroxidation in critically ill patients . Methodology : Forty patients admitted to the intensive care unit were enrolled in this double-blind , r and omized controlled trial . They were r and omized to receive placebo or probiotic for 7 days . Serum levels of Total Antioxidant Capacity ( TAC ) , Malodialdehyde ( MDA ) , C-Reactive Protein ( CRP ) and Acute Physiology and Chronic Health Evaluation ( APACHE II ) score were measured before initiation of the study and on the 7th day . Results : There was a significant difference in CRP levels and APACHE II score between two groups at the end of the study ( P= 0.003 and 0.001 , respectively ) . There was not a significant difference in levels of TAC and MDA between two groups . Conclusions : Administration of  probiotics to critically ill patients caused reduction in inflammation and improvement of clinical outcome . However , there were not significant changes in markers of oxidative stress
Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .