Conclusions Short-term ( 4–12 weeks ) supplementation with vitamin D is associated with lower fasting glucose levels in ESRD with no change in fasting insulin levels .
Abstract Purpose We tested whether short-term vitamin D supplementation improves insulin resistance in patients with kidney disease , a condition with little intrinsic vitamin D activity .
Effects of intravenous calcitriol on lipid profiles and glucose tolerance in uraemic patients with secondary hyperparathyroidism.
1 . Secondary hyperparathyroidism in chronic renal failure may contribute to abnormalities of lipid metabolism and glucose tolerance . Amelioration of secondary hyperparathyroidism has been reported to mitigate the hyperlipidaemia and improve glucose tolerance experimentally . 2 . The effect of the partial suppression of hyperparathyroidism by intravenous calcitriol on lipid levels and glucose tolerance was studied in 15 haemodialysis patients with secondary hyperparathyroidism . All received intravenous calcitriol 1 microgram at the end of haemodialysis thrice weekly for eight weeks . Oral glucose tolerance test and plasma lipid profiles including triglyceride , total cholesterol , high density lipoprotein cholesterol ( HDL-C ) , low density lipoprotein cholesterol ( LDL-C ) , apoprotein A-I and apoprotein B were determined simultaneously before and after eight weeks of therapy . 3 . Before calcitriol treatment , uraemic patients with secondary hyperparathyroidism displayed a significant higher triglyceride and a significant lower HDL-C and apoprotein A-I as well as marked glucose intolerance with an increment of the area below the glucose curve when compared with healthy control subjects . 4 . After eight weeks of calcitriol treatment , there was a significant decrement in serum intact parathyroid hormone ( 476.45 + /- 48.33 versus 191.37 + /- 30.17 ng/l , P < 0.001 ) and plasma triglyceride ( 2.24 + /- 0.34 versus 1.80 + /- 0.29 mmol/l , P < 0.05 ) as well as a significant increment of plasma apoprotein A-I ( 38.13 + /- 2.14 versus 44.19 + /- 2.18 mumol/l , P < 0.05 ) , whereas there was no significant change in serum total cholesterol , LDL-C , HDL-C , and apoprotein B. ( ABSTRACT TRUNCATED AT 250 WORDS
Conclusions Short-term ( 4–12 weeks ) supplementation with vitamin D is associated with lower fasting glucose levels in ESRD with no change in fasting insulin levels .
Abstract Purpose We tested whether short-term vitamin D supplementation improves insulin resistance in patients with kidney disease , a condition with little intrinsic vitamin D activity .