LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Impact of better adherence to statin agents in the primary prevention of coronary artery disease
Background Statins reduce cardiovascular morbidity and mortality after continuous treatment . Studies have shown that less than 50 % of patients take 80 % or more of prescribed doses 1 year after starting therapy . Objective To evaluate the impact of statin adherence on the incidence of coronary artery disease ( CAD ) . Methods A cohort of 115,290 patients was reconstructed using the Régie de l’assurance maladie du Québec data bases . Patients aged 45 to 85 years , without indication of cardiovascular disease ( CVD ) , and newly treated with statins between 1999 and 2004 were eligible . A nested case-control design was used to study CAD . Every case was matched for age and duration of follow-up with r and omly selected controls . The adherence level was measured by calculating the medication possession ratio . Rate ratios ( RR ) of CAD were determined through conditional logistic regression adjusted for several covariates . Results The mean patient age was 63 years , 54 % had hypertension , 26 % had diabetes , and 41 % were males . The proportion of patients with high adherence level to statins  ( ≥ 80 % ) was 74 % during the first year and 53 % after 1 year of follow-up . High adherence was associated with a risk reduction of 18 % [ RR : 0.82 ( 95 % CI : 0.77 - 0.87 ) ] compared to an adherence level of < 20 % . Developing a CVD during follow-up , being male , having been diagnosed with hypertension or diabetes , or having a high chronic disease score increased the risk of CAD . Conclusion Our study suggests that better adherence to statin agents is associated with a significant risk reduction of CAD . Adherence to statin agents needs to be improved so that patients can benefit from the full protective effects of statin therapies
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .