However , it can significantly decrease postintervention and reduction data of FPG , FI , HbA1c , and HOMA-IR .
Heterogeneity was eliminated by subgroup analysis according to baseline BMI .
There was no significant difference in the amelioration of QUICKI between the ITC and control groups .
However , the difference was statistically significant and the heterogeneity was eliminated after subgroup analysis according to intakes of ITC .
Conclusion Supplementation of ITC can ameliorate IR in T2DM , especially in obese T2DM patients , but the effects are controversial in obese patients
Background Insulin resistance ( IR ) is a physiological condition related to type 2 diabetes mellitus ( T2DM ) and obesity , which is associated with high blood insulin and glucose .
Inulin-type carbohydrate ( ITC ) is a kind of fermentable fructan that can reduce glucose and ameliorate IR in an animal model , but the effect in clinical trials is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of ITC supplementation in ameliorating IR in T2DM and obese patients .
A Randomised Crossover Trial: The Effect of Inulin on Glucose Homeostasis in Subtypes of Prediabetes
Background : Fermentable carbohydrates ( FCHO ) have been shown to improve insulin sensitivity in normoglycaemic and insulin-resistant subjects . However , there are no data on subjects with prediabetes . We aim ed to investigate the effect of the FCHO inulin , on glucose homeostasis in subjects with prediabetes . Methods : In a double-blind and placebo-controlled crossover study , 40 volunteers with prediabetes were r and omly allocated to take 30 g/day of inulin or cellulose for 2 weeks in a crossover trial , following a 4-week dose-escalation run-in . Fasting insulin and glucose were measured for all subjects . Fifteen of the 40 subjects also underwent a meal tolerance test to assess insulin sensitivity , free fatty acids and glucagon-like peptide-1 concentrations . A sub analysis was carried out to examine any differences between the prediabetes subtypes . Results : Inulin was associated with a significant increase in ( 0 - 30 min)incremental AUC ( iAUC ) for insulin ( treatment : p < 0.04 ) and ( 0 - 60 min)iAUC for insulin ( treatment : p < 0.04 ) compared to control . There was a significant reduction in insulin resistance measured by the homeostatic model assessment in the isolated-impaired fasting glucose ( p < 0.05 ) but not in the isolated-impaired glucose tolerance groups ( p = 0.59 ) . Conclusion : The FCHO , inulin , may have unique metabolic effects that are of particular benefit to people at risk of diabetes , which warrant further investigation
However , it can significantly decrease postintervention and reduction data of FPG , FI , HbA1c , and HOMA-IR .
Heterogeneity was eliminated by subgroup analysis according to baseline BMI .
There was no significant difference in the amelioration of QUICKI between the ITC and control groups .
However , the difference was statistically significant and the heterogeneity was eliminated after subgroup analysis according to intakes of ITC .
Conclusion Supplementation of ITC can ameliorate IR in T2DM , especially in obese T2DM patients , but the effects are controversial in obese patients
Background Insulin resistance ( IR ) is a physiological condition related to type 2 diabetes mellitus ( T2DM ) and obesity , which is associated with high blood insulin and glucose .
Inulin-type carbohydrate ( ITC ) is a kind of fermentable fructan that can reduce glucose and ameliorate IR in an animal model , but the effect in clinical trials is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of ITC supplementation in ameliorating IR in T2DM and obese patients .