Collectively , the literature reveals pre clinical and clinical evidence for various phytomedicines modulating GABA-pathways , with comparative anxiolytic effect to the current array of pharmaceuticals , along with good safety and tolerability profiles
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress , characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia .
Gamma-aminobutyric acid ( GABA ) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety .
Although current pharmaceutical treatments are often efficacious , they may cause undesirable side effects including cognitive decrements and withdrawal symptoms .
Plant-based " phytomedicines " may provide novel treatment options , to act as an adjunctive or alternative to existing anxiolytic medications .
As such , we conducted a systematic review to assess the current body of literature on anxiolytic phytomedicines and /or phytoconstituents .
Effect of Melissa officinalis Capsule on the Intensity of Premenstrual Syndrome Symptoms in High School Girl Students
Background : Several studies are conducted on Premenstrual Syndrome ( PMS ) . However , a few herbal surveys exist on the treatment of PMS in Iran . Due to the sedative effects of Melissa officinalis ( M. officinalis ) , this question comes to mind that “ can it be used in the treatment of PMS symptoms ? ” Objectives : The current study aim ed to assess the effect of M. officinalis capsule on the intensity of PMS in high-school girls . Material s and Methods : A double-blind r and omized , placebo-controlled trial was performed on 100 high school girls from 2013 to 2014 . The intervention group ( n = 50 ) received 1200 mg of M. officinalis essence daily from the first to the last day of their menstrual cycle for three consecutive cycles . The second group ( n = 50 ) received the placebo . The premenstrual symptoms screening tool was used to assess the intensity of PMS symptoms in the two groups before and one , two , and three months after the intervention . The data were analyzed using paired t-test and repeated measures analysis of variance . Results : The results of repeated measures test revealed a significant reduction ( P < 0.001 ) in PMS symptoms . Overall , the mean score of PMS intensity in the intervention group was 42.56 + 15.73 before the intervention and changed to 32.72 ± 13.24 , 30.02 ± 12.08 , and 13.90 ± 10.22 at the three consecutive months after the intervention , respectively ( P = 0.001 ) . Conclusions : M. officinalis capsules were effective in reduction of the PMS symptoms . Yet , application of this medication requires further investigations
Collectively , the literature reveals pre clinical and clinical evidence for various phytomedicines modulating GABA-pathways , with comparative anxiolytic effect to the current array of pharmaceuticals , along with good safety and tolerability profiles
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress , characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia .
Gamma-aminobutyric acid ( GABA ) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety .
Although current pharmaceutical treatments are often efficacious , they may cause undesirable side effects including cognitive decrements and withdrawal symptoms .
Plant-based " phytomedicines " may provide novel treatment options , to act as an adjunctive or alternative to existing anxiolytic medications .
As such , we conducted a systematic review to assess the current body of literature on anxiolytic phytomedicines and /or phytoconstituents .