Conclusions PDE5Is were significantly more effective than placebo or SSRIs for treating PE , while SSRIs were better than placebo .
The combined treatment had better efficacy than PDE5Is or SSRIs alone
Purpose To clarify the efficacy of phosphodiesterase-5 inhibitors ( PDE5Is ) and selective serotonin reuptake inhibitors ( SSRIs ) in men with premature ejaculation ( PE ) .
[Comparison between sildenafil plus sertraline and sertraline alone in the treatment of premature ejaculation].
OBJECTIVE To compare the efficacy and safety of sildenafil plus sertraline with those of sertraline alone in the treatment of premature ejaculation ( PE ) . METHODS Seventy-two patients with PE but without any obvious organic cause were enrolled in this study . They were r and omly divided into Groups A and B of equal number . Group A received 50 mg sertraline daily 4 to 6 hours before planned sexual activity for 12 weeks , and Group B were given 50 mg sertraline daily plus 50 mg sildenafil as needed , 1 hour before planned sexual activity , for 12 weeks . Before and after the treatment , the mean intravaginal ejaculation latency time , the intercourse satisfaction , the mean number of coituses per week and the drug-related side effects were evaluated . RESULTS The mean intravaginal ejaculatory latency time was ( 0.59 + /- 0.12 ) , ( 3.9 + /- 0.15 ) minutes ( P < 0.001 ) at baseline and post-treatment in Group A , and ( 0.56 + /- 0.11 ) , ( 5.6 + /- 0.12 ) minutes ( P < 0.001 ) in Group B , improved in both of the 2 groups , but more significantly in Group B ( P < 0.05 ) . Before and after the treatment , the mean intercourse satisfaction domain values of the IIEF were ( 8.9 + /- 1.2 ) , ( 10.8 + /- 1.1 ) ( P < 0.05 ) and ( 8.8 + /- 1.1 ) , ( 13.8 + /- 1.3 ) ( P < 0.001 ) in Groups A and B , respectively , significantly greater in Group B than in Group A ( P < 0.05 ) after the treatment ; the mean numbers of coituses per week in Groups A and B were ( 0.9 + /- 0.2 ) , ( 1.9 + /- 0.3 ) ( P < 0.05 ) and ( 1.0 + /- 0.2 ) , ( 2.7 + /- 0.2 ) ( P < 0.001 ) respectively , significantly larger in Group B ( P<0.05 ) after the treatment . As for the side effects , there was a higher rate of headaches ( P < 0.01 ) and flushing episodes ( P < 0.001 ) in Group B than in Group A. CONCLUSION Sertraline combined with sildenafil can produce significantly better results than sertraline alone in patients with premature ejaculation .  However , the combined treatment is associated with a slight increase in the drug-related side effects
Conclusions PDE5Is were significantly more effective than placebo or SSRIs for treating PE , while SSRIs were better than placebo .
The combined treatment had better efficacy than PDE5Is or SSRIs alone
Purpose To clarify the efficacy of phosphodiesterase-5 inhibitors ( PDE5Is ) and selective serotonin reuptake inhibitors ( SSRIs ) in men with premature ejaculation ( PE ) .