There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age
BACKGROUND Long-chain polyunsaturated fatty acids ( LCPUFA ) are important for normal visual and brain development . Although present in human milk , LCPUFA have until recently been absent from artificial formulas , and infants may have limited ability to synthesis e LCPUFA . To determine the clinical significance of this relative deficiency of LCPUFA , we undertook a r and omised trial of the relation between LCPUFA supplementation and infant cognitive behaviour . METHODS 44 term infants had been r and omised to a formula supplemented with LCPUFA ( 21 ) or not supplemented with LCPUFA ( 23 ) , which they had taken from birth to age 4 months .  Infant cognitive behaviour was assessed at 10 months of age by a means-end problem-solving test -- the intentional execution of a sequence of steps to achieve a goal . The problem required three intermediate steps to achieve the final goal , uncovering and retrieving a hidden toy . FINDINGS Infants who received LCPUFA-supplemented formula had significantly more intentional solutions than infants who received the no-LCPUFA formula ( median 2.0 vs 0 , p=0.021 ) . Intention scores ( median 14.0 vs 11.5 [ maximum 18 ] ) were also increased in this group ( p=0.035 ) . INTERPRETATION These findings suggest that term infants may benefit from LCPUFA supplementation , and that the effects persist beyond the period of supplementation . Since higher problem-solving scores in infancy are related to higher childhood IQ scores , supplementation with LCPUFA may be important for the development of childhood intelligence
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .