Conclusions : In summary , the use of ITF may have benefits for LDL-c reduction across all study population s , whereas HDL-c improvement and glucose control were demonstrated only in the T2DM subgroup .
Overall , ITF supplementation may provide a novel direction for improving the lipid profile and glucose metabolism
Inulin-enriched pasta affects lipid profile and Lp(a) concentrations in Italian young healthy male volunteers
Background Inulin has been suggested to have beneficial effects on lipids , especially on triglyceridemia . Few data are available about the effects of inulin on Lipoprotein(a ) , a low-density lipoprotein-like particle considered as an independent risk factor for atherosclerosis . Adding inulin to pasta could be a preventive strategy for delaying the onset of atherosclerosis . Aim of the study was to evaluate the effects of inulin-enriched pasta on lipid profile and on Lipoprotein(a ) in young healthy subjects . Methods Twenty-two young healthy male volunteers entered a r and omized double blind cross-over study consisting of a 2-weeks run-in period , a baseline assessment , two 5-weeks study periods ( 11 % inulin-enriched or control pasta ) , and an 8-weeks wash-out period in between . Serum lipid concentrations were evaluated by routine biochemical analyses and plasma Lipoprotein(a ) concentrations by ELISA . The size of apolipoprotein(a ) isoforms was determined by Western blot and immunodetection . Results Significant differences at baseline and in the treatment groups were found for HDL-cholesterol ( P = 0.004 ) , total cholesterol/HDL-cholesterol ratio ( P = 0.006 ) , triglycerides ( P = 0.04 ) , and Lipoprotein(a ) ( P = 0.02 ) concentrations ( data analyzed by Friedman test ) . Dunn ’s multiple comparison test was used to assess the significance of differences between inulin-enriched pasta diet vs. baseline . HDL-cholesterol concentrations increased by 35.9 % ; total cholesterol/HDL-cholesterol ratio , triglycerides , and Lipoprotein(a ) concentrations decreased by 22.2 , 23.4 , and 16.5 % respectively . Conclusions Inulin-enriched pasta administration induced significant effects on lipid pattern parameters in young healthy volunteers , including a significant reduction in Lipoprotein(a ) concentrations
Conclusions : In summary , the use of ITF may have benefits for LDL-c reduction across all study population s , whereas HDL-c improvement and glucose control were demonstrated only in the T2DM subgroup .
Overall , ITF supplementation may provide a novel direction for improving the lipid profile and glucose metabolism