The available evidence suggests the early changes in cognition may predict treatment response in individuals with MDD .
The results depict an emerging trend towards early changes in facial emotion recognition ( i.e. , a hot cognitive process ) as a predictor of treatment outcome .
Conclusion : The identification of reliable early treatment predictors of antidepressant response would be clinical ly significant , enabling clinicians to more accurately evaluate the efficacy of selected treatment avenues .
HIGHLIGHTSCognitive dysfunction is a principal feature and determinant of health outcome in MDD.Cognitive changes have shown to occur prior to improvements in mood symptoms .
Early changes in emotional processing may predict treatment response in MDD
Background : Despite the widespread use of antidepressants in clinical practice , the current trial‐ and ‐error approach to medication selection contributes to treatment failure and underscores the need to identify reliable predictors of antidepressant response .
Since changes in measures of cognition have been reported to occur early in treatment and prior to improvements in overall mood symptoms , the present review aims to determine whether early changes in measures of cognition can predict response in individuals with MDD .
Dissociable effects of acute antidepressant drug administration on subjective and emotional processing measures in healthy volunteers
Background We have previously shown that single doses of serotonin-selective and noradrenaline-selective antidepressant agents produce positive biases in measures of emotional processing in healthy volunteers . The aim of the present study was to confirm and extend this finding by study ing the effects of a single dose of the selective serotonin and noradrenaline re-uptake inhibitor , duloxetine . Material s and methods Healthy volunteers were r and omly allocated to double-blind administration of either duloxetine 60 mg orally or placebo . Participants then completed a battery of emotional-processing tasks measuring facial expression recognition , emotional memory and emotion-potentiated startle . Subjective state was measured using visual analogue scales throughout the test period . Results Duloxetine enhanced the recognition of both disgusted and happy facial expressions and increased memory intrusions for positive personality characteristics in the free recall test . There were no significant effects on startle responses . However , duloxetine was not well tolerated and was associated with a high level of negative subjective effects . Conclusions Despite the induction of negative subjective effects after duloxetine administration , some positive effects on emotional processing were seen in line with acute administration of serotonin-selective and noradrenaline-selective antidepressant agents . These results confirm the induction of fast changes in emotional processing in healthy volunteer groups and suggest a mechanism by which antidepressants may act in depression . Further studies are required to assess whether positive effects on emotional processing are more selective at a lower dose of duloxetine
The available evidence suggests the early changes in cognition may predict treatment response in individuals with MDD .
The results depict an emerging trend towards early changes in facial emotion recognition ( i.e. , a hot cognitive process ) as a predictor of treatment outcome .
Conclusion : The identification of reliable early treatment predictors of antidepressant response would be clinical ly significant , enabling clinicians to more accurately evaluate the efficacy of selected treatment avenues .
HIGHLIGHTSCognitive dysfunction is a principal feature and determinant of health outcome in MDD.Cognitive changes have shown to occur prior to improvements in mood symptoms .
Early changes in emotional processing may predict treatment response in MDD
Background : Despite the widespread use of antidepressants in clinical practice , the current trial‐ and ‐error approach to medication selection contributes to treatment failure and underscores the need to identify reliable predictors of antidepressant response .
Since changes in measures of cognition have been reported to occur early in treatment and prior to improvements in overall mood symptoms , the present review aims to determine whether early changes in measures of cognition can predict response in individuals with MDD .