However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .
Alpha-linolenic acid supplementation and resistance training in older adults.
Increased inflammation with aging has been linked to sarcopenia . The purpose of this study was to evaluate the effects of supplementing older adults with alpha-linolenic acid ( ALA ) during a resistance training program , based on the hypothesis that ALA decreases the plasma concentration of the inflammatory cytokine tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 , which in turn would improve muscle size and strength . Fifty-one older adults ( 65.4 + /- 0.8 years ) were r and omized to receive ALA in flax oil ( ~14 g.day-1 ) or placebo for 12 weeks while completing a resistance training program ( 3 days a week ) . Subjects were evaluated at baseline and after 12 weeks for muscle thickness of knee and elbow flexors and extensors ( B-mode ultrasound ) , muscle strength ( 1 repetition maximum ) , body composition ( dual energy X-ray absorptiometry ) , and concentrations of TNF-alpha and IL-6 . Males supplementing with ALA  decreased IL-6 concentration over the 12 weeks ( 62 + /- 36 % decrease ; p = 0.003 ) , with no other changes in inflammatory cytokines . Chest and leg press strength , lean tissue mass , muscle thickness , hip bone mineral content and density , and total bone mineral content significantly increased , and percent fat and total body mass decreased with training ( p < 0.05 ) , with the only benefit of ALA being a significantly greater increase in knee flexor muscle thickness in males ( p < 0.05 ) . Total-body bone mineral density improved in the placebo group , with no change in the ALA group ( p = 0.05 ) . ALA supplementation lowers the IL-6 concentration in older men but not women , but had minimal effect on muscle mass and strength during resistance training
However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .