These observational studies also showed positive correlations between early recognition of the disorder , stimulant treatment during childhood and favorable long-term outcome in adult ADHD patients .
In conclusion , stimulant therapy of ADHD has long-term beneficial effects and is well tolerated .
Attention-deficit/hyperactivity disorder ( ADHD ) is a common disorder of childhood that often persists into adulthood .
Although stimulant medications are recommended as the first-line treatment for ADHD because of their documented short-term effects in children and adults , less is known about their effects on long-term outcome in adults .
Here we review the long-term efficacy and safety of the stimulant drugs methylpheni date and amphetamine , as well as the related compound atomoxetine .
We performed a systematic review to identify direct and indirect effects of stimulant therapy on long-term outcome in adults .
Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies
BACKGROUND [ corrected ] Attention-deficit/hyperactivity disorder ( ADHD ) has been less studied in adults than in children , and the treatment studies reported to date have been small , single-center trials . To assess the efficacy of atomoxetine , a new and highly selective inhibitor of the norepinephrine transporter , we conducted two large , multicenter treatment trials . METHODS Two identical studies using r and omized , double-blind , placebo-controlled design s and a 10-week treatment period were conducted in adults with DSM-IV-defined ADHD as assessed by clinical history and confirmed by a structured interview ( study I , n = 280 ; study II , n = 256 ) . The primary outcome measure was a comparison of atomoxetine and placebo using repeated measures mixed model analysis of postbaseline values of the Conners ' Adult ADHD Rating Scale . RESULTS In each study , atomoxetine was statistically superior to placebo in reducing both inattentive and hyperactive and impulsive symptoms as assessed by primary and secondary measures . Discontinuations for adverse events among atomoxetine patients were under 10 % in both studies . CONCLUSION Atomoxetine appears to be an efficacious treatment for adult ADHD . Its lack of abuse potential may be an advantage for many patients
These observational studies also showed positive correlations between early recognition of the disorder , stimulant treatment during childhood and favorable long-term outcome in adult ADHD patients .
In conclusion , stimulant therapy of ADHD has long-term beneficial effects and is well tolerated .
Attention-deficit/hyperactivity disorder ( ADHD ) is a common disorder of childhood that often persists into adulthood .
Although stimulant medications are recommended as the first-line treatment for ADHD because of their documented short-term effects in children and adults , less is known about their effects on long-term outcome in adults .
Here we review the long-term efficacy and safety of the stimulant drugs methylpheni date and amphetamine , as well as the related compound atomoxetine .
We performed a systematic review to identify direct and indirect effects of stimulant therapy on long-term outcome in adults .