The analysis showed a positive association of adopting the Paleolithic diet in relation to weight loss .
Conclusion The Paleolithic diet may assist in controlling weight and waist circumference and in the management of chronic diseases .
Background The Paleolithic diet has been studied in the scope of prevention and control of chronic noncommunicable diseases ( CNCD ) .
The objective of this study was to analyze the influence of the Paleolithic diet on the prevention and control of CNCD in humans , specifically on anthropometric markers , through a systematic review with meta- analysis .
Methods What is the effect of the Paleolithic diet on anthropometric parameters ( weight , body mass index and waist circumference ) compared to other control diets based on recommendations in adults ?
A multimodal intervention for patients with secondary progressive multiple sclerosis: feasibility and effect on fatigue.
BACKGROUND Multiple sclerosis is an autoimmune disease influenced by environmental factors . OBJECTIVES The feasibility of a multimodal intervention and its effect on perceived fatigue in patients with secondary progressive multiple sclerosis were assessed . DESIGN / SETTING This was a single-arm , open-label intervention study in an outpatient setting . INTERVENTIONS A multimodal intervention including a modified paleolithic diet with supplements , stretching , strengthening exercises with electrical stimulation of trunk and lower limb muscles , meditation , and massage was used . OUTCOME MEASURES Adherence to each component of the intervention was calculated using daily logs . Side-effects were assessed from a monthly question naire and blood analyses . Fatigue was assessed using the Fatigue Severity Scale ( FSS ) . Data were collected at baseline and months 1 , 2 , 3 , 6 , 9 , and 12 . RESULTS Ten ( 10 ) of 13 subjects who were enrolled in a 2-week run-in phase were eligible to continue in the 12-month main study . Of those 10 subjects , 8 completed the study and 6 subjects fully adhered to the study intervention for 12 months . Over a 12-month period , average adherence to diet exceeded 90 % of days , and to  exercise/muscle stimulation  exceeded 75 % of days .  Nutritional supplements  intake varied among and within subjects . Group daily average duration of meditation  was 13.3 minutes and of massage was 7.2 minutes . No adverse side-effects were reported . Group average FSS scores decreased from 5.7 at baseline to 3.32 ( p=0.0008 ) at 12 months . CONCLUSIONS In this small , uncontrolled pilot study , there was a significant improvement in  fatigue  in those who completed the study . Given the small sample size and completer rate , further evaluation of this multimodal therapy is warranted
The analysis showed a positive association of adopting the Paleolithic diet in relation to weight loss .
Conclusion The Paleolithic diet may assist in controlling weight and waist circumference and in the management of chronic diseases .
Background The Paleolithic diet has been studied in the scope of prevention and control of chronic noncommunicable diseases ( CNCD ) .
The objective of this study was to analyze the influence of the Paleolithic diet on the prevention and control of CNCD in humans , specifically on anthropometric markers , through a systematic review with meta- analysis .
Methods What is the effect of the Paleolithic diet on anthropometric parameters ( weight , body mass index and waist circumference ) compared to other control diets based on recommendations in adults ?