Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .
The effect of orally administered probiotic Lactobacillus reuteri-containing tablets in peri-implant mucositis: a double-blind randomized controlled trial.
BACKGROUND AND OBJECTIVES Probiotics create a biofilm and protect the oral tissues against the action of periodontal pathogenic bacteria . The aim of this study was to evaluate the effects of the oral probiotic Lactobacillus reuteri Prodentis upon the peri-implant health of edentulous patients with dental implants and peri-implant mucositis , establishing comparisons vs implants without peri-implant disease . MATERIAL AND METHODS A double-blind , placebo-controlled , prospect i ve cross-over study was made . The patients were all edentulous and were divided into two groups , ( A ) no peri-implant disease , and ( B ) peri-implant mucositis affecting one or more implants . Patients with peri-implantitis were excluded . The dosage was one tablet every 24 h over 30 d. All patients in both groups initially received the oral probiotic Lactobacillus reuteri Prodentis , followed by placebo . Patients started with probiotic treatment during 30 d , followed by a 6 mo washout period and the administration of placebo for the same period . The following parameters were studied : crevicular fluid volume , modified plaque index , probing depth , modified gingival index , and concentrations of interleukin 1β , interleukin 6 and interleukin 8 . RESULTS A total of 77 implants were evaluated in 34 patients . Group A involved 22 patients with 54 implants without peri-implant alterations , and group B , 12 patients with mucositis affecting one or more implants ( 23 implants ) . After treatment with the probiotic , both the patients with mucositis and the patients without peri-implant disease showed improvements in the clinical parameters , with reductions in cytokine levels . In contrast , no such changes were observed with placebo . CONCLUSIONS After treatment with the probiotic Lactobacillus reuteri in patients with implants presenting mucositis , the clinical parameters improved , and the cytokine levels decreased - in contraposition to the observations in the placebo group . Probiotic administration may be regarded as a good alternative for both the treatment of peri-implant mucositis and its prevention , as it also improved clinical parameters in the healthy individuals . Further studies involving larger patient series are needed regarding the effects of probiotics upon peri-implant health
Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .