We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .
A randomized double-blind clinical trial of xipamid and hydrochlorothiazide in essential hypertension.
Seventeen patients with mild to moderate essential hypertension and controlled with antihypertensive drugs were treated with xipamid ( 40 mg ) or hydrochlorothiazide ( 50 mg ) in a double-blind cross-over r and omized trial design . After a run-in-period of 2 weeks with placebo , all of them received either of the two drugs . Placebo treatment for 2 weeks decreased both supine as well as st and ing blood pressure , but it was not statistically significant . Xipamid produced a somewhat greater decrease in blood pressure than hydrochlorothiazide , but the difference was not statistically significant . Similar results were obtained in 12 newly diagnosed cases of mild to moderate essential hypertension treated with xipamid ( 80 mg ) or hydrochlorothiazide ( 100 mg ) daily as single drug treatment in a r and omized , double-blind parallel design trial . The side effects produced by both drugs were only mild in nature . No significant changes were produced in serum electrolytes , uric acid and fasting blood glucose in this short term study with either of the drugs
We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .