Intake of a carbohydrate-containing fluid is reported to improve insulin-like growth factor levels , reduce hunger , nausea , and length of stay , and attenuate the decrease in whole-body insulin sensitivity and endogenous glucose release .
Amino acid supplementation is reported to reduce muscle atrophy and accelerate return of functional mobility .
There is limited evidence for nutritional supplementation in THR and TKR pathways ; however , the low risk profile and potential benefits to adjunctive treatment methods , such as exercise programs , suggest nutritional supplements may have a role .
Optimizing nutritional status pre-operatively may help manage the surgical stress response , with a particular benefit for undernourished , frail , or elderly individuals
Nutritional supplements can influence outcomes for individuals undergoing major surgery , particularly in older persons whose functional reserve is limited .
Accelerating recovery from total hip replacement ( THR ) and total knee replacement ( TKR ) may offer significant benefits .
Therefore , we explored the role of nutritional supplements in improving recovery following THR and TKR .
A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial
Protein and other compounds can exert anabolic effects on skeletal muscle , particularly in conjunction with exercise . The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based , multi-ingredient nutritional supplement to increase strength and lean mass independent of , and in combination with , exercise in healthy older men . Forty-nine healthy older men ( age : 73 ± 1 years [ mean ± SEM ] ; BMI : 28.5 ± 1.5 kg/m2 ) were r and omly allocated to 20 weeks of twice daily consumption of either a nutritional supplement ( SUPP ; n = 25 ; 30 g whey protein , 2.5 g creatine , 500 IU vitamin D , 400 mg calcium , and 1500 mg n-3 PUFA with 700 mg as eicosapentanoic acid and 445 mg as docosahexanoic acid ) ; or a control ( n = 24 ; CON ; 22 g of maltodextrin ) . The study had two phases . Phase 1 was 6 weeks of SUPP or CON alone . Phase 2 was a 12 week continuation of the SUPP/CON but in combination with exercise : SUPP + EX or CON + EX  . Isotonic strength ( one repetition maximum [ 1RM ] ) and lean body mass ( LBM ) were the primary outcomes . In Phase 1 only the SUPP group gained strength ( Σ1RM , SUPP : + 14 ± 4 kg , CON : + 3 ± 2 kg , P < 0.001 ) and lean mass ( LBM , + 1.2 ± 0.3 kg , CON : -0.1 ± 0.2 kg , P < 0.001 ) . Although both groups gained strength during Phase 2 , upon completion of the study upper body strength was greater in the SUPP group compared to the CON group ( Σ upper body 1RM : 119 ± 4 vs. 109 ± 5 kg , P = 0.039 ) . We conclude that twice daily consumption of a multi-ingredient nutritional supplement  increased muscle strength and lean mass in older men . Increases in strength were enhanced further with exercise training . Trial Registration : Clinical Trials.gov
Intake of a carbohydrate-containing fluid is reported to improve insulin-like growth factor levels , reduce hunger , nausea , and length of stay , and attenuate the decrease in whole-body insulin sensitivity and endogenous glucose release .
Amino acid supplementation is reported to reduce muscle atrophy and accelerate return of functional mobility .
There is limited evidence for nutritional supplementation in THR and TKR pathways ; however , the low risk profile and potential benefits to adjunctive treatment methods , such as exercise programs , suggest nutritional supplements may have a role .
Optimizing nutritional status pre-operatively may help manage the surgical stress response , with a particular benefit for undernourished , frail , or elderly individuals
Nutritional supplements can influence outcomes for individuals undergoing major surgery , particularly in older persons whose functional reserve is limited .
Accelerating recovery from total hip replacement ( THR ) and total knee replacement ( TKR ) may offer significant benefits .
Therefore , we explored the role of nutritional supplements in improving recovery following THR and TKR .