Although the level of evidence for the effects of vitamin D on vaginal health is low in our study , we concluded that vitamin D may improve the vaginal health of women , especially during menopause
Menopause is associated with the onset of climacteric symptoms due to low estradiol levels , which may cause insufficient maturation of the vaginal mucosa .
Vitamin D may regulate the growth and differentiation of cells that are adversely affected due to low estradiol levels , thereby restoring vaginal health .
The objective of this systematic review , the first on this subject , was to investigate the effect of vitamin D on the  vaginal health of menopausal women .
Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause.
AIM Affective and behavioural disorders possibly concomitant to the vasomotor menopausal symptoms worsen quality of life . A rational formulation containing soy isoflavones ( 60 mg ) , lactobacilli ( 500 millions spores ) , calcium ( 141 mg ) and vitamin D3 ( 5 microg ) was added of Magnolia bark extract ( 60 mg ) and magnesium ( 50 mg ) ( Estromineral serena , ES ) . The Magnolia extract active principles interact with GABA system and exhibit a sedative central action . Magnesium intervenes in enzymatic reactions of the energetic metabolism and protects the bone integrity . Aim of this controlled study was to compare the clinical activity and safety of ES versus calcium+vitamin D3 ( Ca+D ) in menopause . METHODS A controlled , r and omised , multicentre study was carried out in symptomatic menopausal women with sleep or mood alterations . Women received 1 tablet/day of ES or Ca+D for 24 weeks . Symptoms during the treatment and final judgements on efficacy and acceptability were evaluated . RESULTS Eighty-nine women ( 44 ES and 45 Ca+D , mean age 53.8 years , in menopause since 56.6 months ) participated to the study .  Flushing , nocturnal sweating , palpitations , insomnia , asthenia , anxiety , mood depression , irritability , vaginal dryness , dyspareunia , and libido loss , significantly decreased in severity and frequency during ES versus Ca+D treatment even since the fourth week . Woman wellbeing ( good/very good 66.7 % vs 20 % ) judgement on efficacy ( 72.7 % vs 17.1 % ) and acceptability ( 93.9 % vs 31.4 % ) were significantly better for ES . CONCLUSIONS The controlled study showed the efficacy of Magnolia extract and magnesium on psycho-affective and sleep disturbances in menopause , in addition to the effects of isoflavones on vasomotor symptoms . A global natural approach to menopause with ES evidence d its therapeutic usefulness and safety
Although the level of evidence for the effects of vitamin D on vaginal health is low in our study , we concluded that vitamin D may improve the vaginal health of women , especially during menopause
Menopause is associated with the onset of climacteric symptoms due to low estradiol levels , which may cause insufficient maturation of the vaginal mucosa .
Vitamin D may regulate the growth and differentiation of cells that are adversely affected due to low estradiol levels , thereby restoring vaginal health .
The objective of this systematic review , the first on this subject , was to investigate the effect of vitamin D on the  vaginal health of menopausal women .