There was no significant difference in relation to the resolution of fever , abscess size , and hospital stay .
The beneficial effects of PA were seen with medium-to-large ( > 5 cm ) ALA and not with small ( < 5 cm ) ALA .
Percutaneous aspiration as compared with metronidazole alone results in the early resolution of pain and tenderness in patients with medium-to-large ALA .
Percutaneous catheter drainage is better for larger ALA .
The role of metronidazole alone , percutaneous aspiration ( PA ) , and percutaneous catheter drainage ( PCD ) in the treatment of uncomplicated amebic liver abscess ( ALA ) is still unclear .
This systematic review and meta- analysis evaluated the available evidence s with regard to treatment modalities in such patients .
Comparative study of tinidazole and metronidazole in amoebic liver abscess.
Twenty proven cases of amoebic liver abscess were treated at r and om with either tinidazole or metronidazole . The dose of both was 2 g once daily for 2 days . Clinical , radiological , and biochemical follow-up was done for 30 days . Of the 19 patients who completed the trial , complete recovery was observed in all 10 patients given tinidazole and in 5 of 9 patients given metronidazole ( p=0.05 ) . Moreover , patients on tinidazole required repeat aspirations less frequently than those on metronidazole .  Mild gastrointestinal side-effects occurred in 1 patient on metronidazole . The results suggest that tinidazole is a more efficacious drug than metronidazole , with rapid therapeutic effect
There was no significant difference in relation to the resolution of fever , abscess size , and hospital stay .
The beneficial effects of PA were seen with medium-to-large ( > 5 cm ) ALA and not with small ( < 5 cm ) ALA .
Percutaneous aspiration as compared with metronidazole alone results in the early resolution of pain and tenderness in patients with medium-to-large ALA .
Percutaneous catheter drainage is better for larger ALA .
The role of metronidazole alone , percutaneous aspiration ( PA ) , and percutaneous catheter drainage ( PCD ) in the treatment of uncomplicated amebic liver abscess ( ALA ) is still unclear .
This systematic review and meta- analysis evaluated the available evidence s with regard to treatment modalities in such patients .