Although some systematic review s have not established an unequivocal benefit of physical training , most authors report a benefit for patients with chronic pain or fatigue .
OBJECTIVE To review the published information on physical training for fibromyalgia ( FM ) and related syndromes .
Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double-blind clinical trial.
OBJECTIVE To compare the relative efficacy and tolerability of amitriptyline , cyclobenzaprine , and placebo in the treatment of fibromyalgia , and to identify predictors of response to amitriptyline and cyclobenzaprine . METHODS Two hundred eight patients who fulfilled the American College of Rheumatology criteria for the classification of fibromyalgia were entered into a 6-month prospect i ve , double-blind , multicenter trial and were r and omized to 1 of 3 treatment groups : amitriptyline , cyclobenzaprine , or placebo . RESULTS After 1 month , 21 % , 12 % , and 0 % of the amitriptyline , cyclobenzaprine , and placebo patients , respectively , had significant clinical improvement  ( amitriptyline versus placebo P = 0.002 , cyclobenzaprine versus placebo P = 0.02 , amitriptyline versus cyclobenzaprine P not significant ) . These percentages increased to 36 % , 33 % , and 19 % , respectively , at the 6-month assessment ( P not significant ) . The nature and frequency of side effects reported by patients treated with amitriptyline and those reported by patients treated with cyclobenzaprine were similar . A normal Minnesota Multiphasic Personality Inventory ( MMPI ) profile at baseline was predictive of clinical improvement at the 1-month evaluation ( odds ratio 3.3 , 95 % confidence interval 1.2 - 9.0 ) . However , neither the MMPI profile nor any of the demographic , clinical , or functional parameters evaluated at baseline predicted long-term response . CONCLUSION Our data confirm the short-term efficacy of amitriptyline and cyclobenzaprine in a small percentage of patients with fibromyalgia . Long-term efficacy could not be demonstrated because of a higher-than-expected placebo response . Predictors of response to these drugs could not be determined
Although some systematic review s have not established an unequivocal benefit of physical training , most authors report a benefit for patients with chronic pain or fatigue .
OBJECTIVE To review the published information on physical training for fibromyalgia ( FM ) and related syndromes .