On the contrary , the largest study of this review did not demonstrate any adverse effect of  DM on MWD and FWD after SET .
In conclusion , the data evaluating the effects of DM on SET were inadequate to determine if DM impairs the exercise response .
Some believe that certain patients with intermittent claudication may be unsuitable for supervised exercise therapy ( SET ) , based on the presence of comorbidities and the possibly increased risks .
We conducted a systematic review ( MEDLINE , EMBASE and CENTRAL ) to summarize evidence on the potential influence of diabetes mellitus ( DM ) on the response to SET .
Peripheral arterial disease in diabetic and nondiabetic patients: a comparison of severity and outcome.
OBJECTIVE The aim of this study was to quantify the distribution of peripheral arterial disease in the diabetic and nondiabetic population attending for angiography and to compare severity and outcome between both groups of patients . RESEARCH DESIGN AND METHODS R  and omly selected lower-extremity angiograms were examined according to the Bollinger system . Patient demographics and medical history were recorded and case notes were examined to determine which patients later underwent a revascularization procedure or amputation and which patients had died . RESULTS A total of 136 arteriograms obtained between 1992 and 1996 were analyzed . The age ( mean + /- SD ) of the patients was 64.7 + /- 10.8 years . Diabetic patients ( 43 % ) and nondiabetic patients were of similar age ( 63.9 + /- 10.4 vs. 65.3 + /- 11.1 years , P = 0.43 ) , with a similar history of smoking ( 81.0 vs. 76.9 % , P = 0.26 ) , ischemic heart disease ( 41.4 vs. 37.2 % , P = 0.54 ) , and hypercholesterolemia ( 24.4 vs. 30.8 % , P = 0.48 ) . However , there were a greater proportion of hypertensive patients in the diabetic group ( 63.8 vs. 39.7 % , P = 0.006 ) . Diabetic patients had greater severity of arterial disease in the profunda femoris and all arterial segments below the knee ( P = 0.02 ) . A greater number of amputations occurred in the diabetic group : diabetic patients were five times more likely to have an amputation ( 41.4 vs. 11.5 % , odds ratio [ OR ] 5.4 , P < 0.0001 ) . Mortality was higher in the diabetic group ( 51.7 vs. 25.6 % , OR 3.1 , P = 0.002 ) , and diabetic patients who died were younger at presentation than nondiabetic patients ( 64.7 + /- 11.4 vs. 71.1 + /- 8.7 years , P = 0.04 ) . CONCLUSIONS In patients with peripheral arterial disease , diabetic patients have worse arterial disease and a poorer outcome than nondiabetic patients
On the contrary , the largest study of this review did not demonstrate any adverse effect of  DM on MWD and FWD after SET .
In conclusion , the data evaluating the effects of DM on SET were inadequate to determine if DM impairs the exercise response .
Some believe that certain patients with intermittent claudication may be unsuitable for supervised exercise therapy ( SET ) , based on the presence of comorbidities and the possibly increased risks .
We conducted a systematic review ( MEDLINE , EMBASE and CENTRAL ) to summarize evidence on the potential influence of diabetes mellitus ( DM ) on the response to SET .