SUMMARY The use of statins was significantly associated with a decreased risk of atrial fibrillation in patients with sinus rhythm .
PURPOSE OF REVIEW Whether statins may prevent  atrial fibrillation  remains a subject of debate .
Effect of rosuvastatin pretreatment on myocardial damage after coronary surgery: a randomized trial.
OBJECTIVE Myocardial disease without evidence of myocardial infa rct ion is a frequent complication after cardiac surgery during cardiopulmonary bypass .  Statins might be protective , but their efficacy has not been established in r and omized trials . METHODS Two hundred patients undergoing coronary surgery were enrolled . They were r and omized to rosuvastatin ( 20 mg/d , n = 100 ) or placebo ( n = 100 ) starting 1 week before the operation . Troponin I , myoglobin , creatine kinase-MB mass , and high-sensitivity C-reactive protein were used as markers of myocardial injury , and their values were determined at baseline and at regular intervals after the operation .  Electrocardiography and echocardiography  were performed before and after the operation . RESULTS Myocardial disease was diagnosed when troponin I , myoglobin , and creatine kinase-MB mass values were above the upper normal limit without evidence of electrocardiographic changes , echocardiographic changes , or both . The percentages of marker level increase indicative of myocardial disease were determined in the placebo versus statin groups and were as follows : troponin I , 35 % versus 65 % ( P < .0001 ) ; myoglobin , 39 % versus 72 % ( P < .0001 ) ; creatine kinase-MB mass , 22 % versus 40 % ( P = .0002 ) . Peak postoperative values of troponin I ( 0.16 + /- 0.15 vs 0.32 + /- 0.26 ng/mL , P = .0008 ) , myoglobin ( 72.25 + /- 25 vs 98.31 + /- 31 ng/mL , P < .0001 ) , and creatine kinase-MB mass ( 3.9 + /- 3.3 vs 9.3 + /- 8.1 ng/mL , P < .0001 ) were significantly higher in the placebo group . High-sensitivity C-reactive protein values were increased in 58 % of pretreated versus 88 % of the control patients ( 15.4 + /- 2.5 vs 17.2 + /- 3.4 mg/L , P < .0001 ) . In high-risk patients myocardial disease was observed more frequently but significantly less in statin-pretreated patients . CONCLUSIONS Statin pretreatment reduces myocardial damage after coronary surgery and could improve both short- and long-term results
SUMMARY The use of statins was significantly associated with a decreased risk of atrial fibrillation in patients with sinus rhythm .
PURPOSE OF REVIEW Whether statins may prevent  atrial fibrillation  remains a subject of debate .