Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .
Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia.
Chronic acid loads are an obligate consequence of the high animal/grain protein content of the Western diet . The effect of this diet-induced metabolic acidosis on bone mass is controversial . In a r and omized , prospect i ve , controlled , double-blind trial , 161 postmenopausal women ( age 58.6 + /- 4.8 yr ) with low bone mass ( T score -1 to -4 ) were r and omly assigned to 30 mEq of oral potassium ( K ) citrate ( Kcitrate ) or 30 mEq of K chloride ( KCl ) daily . The primary end point was the intergroup difference in mean percentage change in bone mineral density ( BMD ) at lumbar spine ( L2 through L4 ) after 12 mo . Compared with the women who received KCl , women who received Kcitrate exhibited an intergroup increase in BMD ( + /-SE ) of 1.87 + /- 0.50 % at L2 through L4 ( P < 0.001 ) , of 1.39 + /- 0.48 % ( P < 0.001 ) at femoral neck , and of 1.98 + /- 0.51 % ( P < 0.001 ) at total hip . Significant secondary end point intragroup changes also were found : Kcitrate increased L2 through L4 BMD significantly from baseline at months 3 , 9 , and 12 and reached a month 12 increase of 0.89 + /- 0.30 % ( P < 0.05 ) , whereas the KCl arm showed a decreased L2 through L4 BMD by -0.98 + /- 0.38 % ( P < 0.05 ) , significant only at month 12 . Intergroup differences for distal radius and total body were NS . The Kcitrate-treated group demonstrated a sustained and significant reduction in urinary calcium excretion and a significant increase in urinary citrate excretion , with increased citrate excretion indicative of sustained systemic alkalization . Urinary bone resorption marker excretion rates were significantly reduced by Kcitrate , and for deoxypyridinoline , the intergroup difference was significant . Urinary net acid excretion correlated inversely and significantly with the change in BMD in a subset of patients . Large and significant reductions in BP were observed for both K supplements during the entire 12 mo . Bone mass can be increased significantly in postmenopausal women with osteopenia by increasing their daily alkali intake as citrate , and the effect is independent of reported skeletal effects of
Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .