The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Lisinopril dose-response relationship in essential hypertension.
1 . This was a multicentre , double-blind , parallel study in 216 patients with mild to moderate ( supine diastolic blood pressure = 95 - 115 mm Hg ) essential hypertension . 2 . After a 4-week placebo washout , patients were r and omized to placebo or lisinopril 1.25 , 5.20 or 80 mg once daily for 6 consecutive weeks . Supine and erect blood pressure was measured 24 h postdose at the end of weeks -2 , 0 , 2 , 4 , and 6 . 3 . There was a linear dose-response relationship for both supine and erect blood pressure . Diastolic blood pressure reductions in the lisinopril 20 and 80 mg day-1 groups were significantly greater than in the placebo or lisinopril 1.25 and 5 mg day-1 groups . 4 . Lisinopril , at doses up to 80 mg day-1 , was well tolerated
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .