On the contrary , the largest study of this review did not demonstrate any adverse effect of  DM on MWD and FWD after SET .
In conclusion , the data evaluating the effects of DM on SET were inadequate to determine if DM impairs the exercise response .
Some believe that certain patients with intermittent claudication may be unsuitable for supervised exercise therapy ( SET ) , based on the presence of comorbidities and the possibly increased risks .
We conducted a systematic review ( MEDLINE , EMBASE and CENTRAL ) to summarize evidence on the potential influence of diabetes mellitus ( DM ) on the response to SET .
Influence of diabetes on mortality in acute myocardial infarction: data from the GISSI-2 study.
OBJECTIVES This study was conducted to determine the role of insulin-dependent and noninsulin-dependent diabetes in the prognosis of patients after myocardial infa rct ion and treatment with fibrinolytic agents .  BACKGROUND Several studies have shown that diabetic patients have a high mortality rate after acute myocardial infa rct ion . However , the impact of diabetes on survival in patients treated with fibrinolytic agents  is still undefined . It is also not known whether the type of diabetes or gender affects prognosis . METHODS We analyzed prevalence and prognostic significance of a history of diabetes in patients enrolled in the GISSI-2 study , all of whom received fibrinolytic agents .  The incidence of deaths in the hospital and at 6 months after study entry was computed for patients without diabetes and for insulin-dependent and noninsulin-dependent diabetic patients ; relative risks were evaluated by univariate and multivariate analysis . RESULTS Information on diabetic status was available for 11,667 patients , 94.2 % of those r and omized in the GISSI-2 study . The prevalence of diabetes was higher in women than in men ( 8.75 % vs. 1.85 % , p < 0.01 for insulin-dependent and 23.7 % vs. 13.8 % , p < 0.01 for noninsulin-dependent diabetic patients ) . The type of fibrinolytic agent did not affect mortality rates ; the increase in in-hospital mortality of diabetic patients was moderate and similar for men with insulin- and noninsulin-dependent diabetes ( 8.7 % and 10.1 % , respectively , vs. 5.8 % in nondiabetic patients ) ; in women , mortality was markedly higher for insulin-dependent and only slightly higher for noninsulin-dependent diabetic patients ( 24.0 % and 15.8 % , respectively , vs. 13.9 % for nondiabetic patients ) . The adjusted relative risks were 1.9 ( 95 % confidence interval 1.2 to 2.9 ) for insulin-dependent diabetic women and 1.4 ( 95 % confidence interval 1.1 to 1.8 ) for noninsulin-dependent diabetic men . The mortality rate after discharge showed a similar gender difference , and in insulin-dependent diabetic women , prognosis was ominous even in the absence of left ventricular damage before discharge . CONCLUSIONS A history of diabetes is associated with a worse prognosis after myocardial infa rct ion , even in patients treated with fibrinolytic agents . Gender and type of diabetes appear to be critical in affecting survival . In men , both insulin-dependent and noninsulin-dependent diabetes are associated with a moderately higher mortality rate ;  in women , insulin-dependent diabetes is , in itself , a strong risk factor for death after myocardial infa rct ion
On the contrary , the largest study of this review did not demonstrate any adverse effect of  DM on MWD and FWD after SET .
In conclusion , the data evaluating the effects of DM on SET were inadequate to determine if DM impairs the exercise response .
Some believe that certain patients with intermittent claudication may be unsuitable for supervised exercise therapy ( SET ) , based on the presence of comorbidities and the possibly increased risks .
We conducted a systematic review ( MEDLINE , EMBASE and CENTRAL ) to summarize evidence on the potential influence of diabetes mellitus ( DM ) on the response to SET .