There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Impaired Fetal Growth and Arterial Wall Thickening: A Randomized Trial of Omega-3 Supplementation
OBJECTIVES : Impaired fetal growth is an independent cardiovascular risk factor and is associated with arterial wall thickening in children . No preventive strategy has been identified . We sought to determine whether dietary omega-3 fatty acid supplementation during early childhood prevents the association between impaired fetal growth and carotid arterial wall thickening . METHODS : The Childhood Asthma Prevention Study was a r and omized , controlled single-blind trial in 616 children born at term , recruited antenatally from maternity hospitals in Sydney . Participants were r and omized to either a 500-mg-daily fish oil supplement and canola-based margarines and cooking oil ( omega-3 group ) , or a 500-mg-daily sunflower oil supplement and omega-6 fatty acid – rich margarines and cooking oil ( control group ) , from the start of bottle-feeding or 6 months of age until 5 years of age . Carotid intima-media thickness ( IMT ) , a noninvasive measure of sub clinical atherosclerosis , was the primary endpoint of a cardiovascular sub study ( CardioCAPS ) at age 8 years . We examined the association of fetal growth with carotid IMT in children with birth weight < 90th percentile ( omega-3 group [ n = 187 ] , control group [ n = 176 ] ) . RESULTS : In the control group , fetal growth was inversely associated with carotid IMT , but this was prevented in the omega-3 group ( difference between groups of 0.041 mm [ 95 % confidence interval 0.006 , 0.075 ] per kg birth weight , adjusted for gestational age and gender , Pheterogeneity = .02 ) . CONCLUSIONS : The inverse association of fetal growth with arterial wall thickness in childhood can be prevented by dietary omega-3 fatty acid supplementation over the first 5 years of life
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .