In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
Cyclamate consumption in Catalonia, Spain (1992): relationship with the body mass index.
The dietary intake of cyclamate was evaluated in the north-east of Spain in 1992 . In a r and om sample of the Catalan population consisting of 2450 people aged 6 - 75 years , two 24-h recalls at different seasons were collected ; the amount and type of all foods , drinks and drugs consumed were obtained and the total daily intake of cyclamate was expressed in mg/kg body weight ( bw ) , as the average of both 24-h recalls . Eighteen percent of the population consumed cyclamate , and the highest percentage was in men aged 35 - 44 years ( 33 % ) . Average daily intake of  cyclamate was 0.44 mg/kg bw in the whole population and 2.44 mg/kg bw among consumers . Subjects following a diet reported highest intakes , especially diabetics , and only 0.16 % of the sample studied had levels above the Acceptable Daily Intake ( ADI ) . Among consumers , the intake of cyclamate was negatively correlated with Body Mass Index ( BMI ) . The results show the pattern of cyclamate intake in the Spanish population
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .