However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .
Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools.
BACKGROUND Dietary linoleic acid ( LA , 18:2n-6 ) lowering  in rats reduces n-6 polyunsaturated fatty acid ( PUFA ) plasma concentrations and increases n-3 PUFA ( eicosapentaenoic ( EPA ) and docosahexaenoic acid ( DHA ) ) concentrations . OBJECTIVE To evaluate the extent to which 12 weeks of dietary n-6 PUFA lowering , with or without increased dietary n-3 PUFAs , alters unesterified and esterified plasma n-6 and n-3 PUFA concentrations in subjects with chronic headache . DESIGN Secondary analysis of a r and omized trial . Subjects with chronic headache were r and omized for 12 weeks to ( 1 ) average n-3 , low n-6 ( L6 ) diet ; or ( 2 ) high n-3 , low n-6 LA ( H3-L6 ) diet .  Esterified and unesterified plasma fatty acids were quantified at baseline ( 0 weeks ) and after 12 weeks on a diet . RESULTS Compared to baseline , the L6 diet reduced esterified plasma LA and increased esterified n-3 PUFA concentrations ( nmol/ml ) , but did not significantly change plasma arachidonic acid ( AA , 20:4n-6 ) concentration . In addition , unesterified EPA concentration was increased significantly among unesterified fatty acids . The H3-L6 diet decreased esterified LA and AA concentrations , and produced more marked increases in esterified and unesterified n-3 PUFA concentrations . CONCLUSION Dietary n-6 PUFA lowering for 12 weeks significantly reduces LA and increases n-3 PUFA concentrations in plasma , without altering plasma AA concentration . A concurrent increase in dietary n-3 PUFAs for 12 weeks further increases n-3 PUFA plasma concentrations and reduces AA
However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .