AUTHORS ' CONCLUSIONS Addition of ox and rolone to the GH therapy led to a modest increase in the final adult height of girls aged up to 18 years with TS .
BACKGROUND The final adult height of untreated girls aged up to 18 years with Turner syndrome ( TS ) is approximately 20 cm shorter compared with healthy females .
Treatment with growth hormone ( GH ) increases the adult height of people with TS .
The effects of adding the and rogen , ox and rolone , in addition to GH are unclear .
Therefore , we conducted this systematic review to investigate the benefits and harms of ox and rolone as an adjuvant therapy for people with TS treated with GH .
OBJECTIVES To assess the effects of ox and rolone on growth hormone-treated girls aged up to 18 years with Turner syndrome .
The effect of the weak androgen oxandrolone on psychological and behavioral characteristics in growth hormone-treated girls with Turner syndrome
The weak and rogen ox and rolone ( Ox ) increases height gain in growth-hormone ( GH ) treated girls with Turner syndrome ( TS ) , but may also give rise to virilizing side effects . To assess the effect of Ox , at a conventional and low dosage , on behavior , aggression , romantic and sexual interest , mood , and gender role in GH-treated girls with TS , a r and omized , placebo-controlled , double-blind study was conducted . 133 patients were treated with GH ( 1.33 mg/m(2)/d ) from baseline , combined with placebo ( Pl ) , Ox 0.03 mg/kg/d , or Ox 0.06 mg/kg/d from the age of eight , and with estrogens from the age of 12 . The child behavior checklist ( CBCL ) , Junior Dutch Personality Question naire ( DPQ-J ) , State-subscale of the Spielberger 's State-Trait Anger Scale , Romantic and Sexual Interest Question naire , Mood Question naire , and Gender Role Question naire were filled out before , during , and after discontinuing Ox/Pl . The changes during Ox/Pl therapy were not significantly different between the dosage groups . In untreated patients , the mean CBCL total ( P=0.002 ) and internalizing ( P=0.003 ) T scores , as well as the mean DPQ-J social inadequacy SD score ( SDS ) ( P=0.004 ) were higher than in reference girls , but decreased during GH+Ox/Pl therapy ( P<0.001 , P=0.05 , P<0.001 , respectively ) . Whereas the mean total ( P=0.01 ) and internalizing ( P<0.001 ) T score remained relatively high , the mean social inadequacy SDS became comparable with reference values . We conclude that in GH-treated girls with TS , Ox 0.03 mg/kg/d or 0.06 mg/kg/d does not cause evident psychological virilizing side effects . Problem behavior , frequently present in untreated girls with TS , decreases during therapy , but total and internalizing problem behavior remain increased
AUTHORS ' CONCLUSIONS Addition of ox and rolone to the GH therapy led to a modest increase in the final adult height of girls aged up to 18 years with TS .
BACKGROUND The final adult height of untreated girls aged up to 18 years with Turner syndrome ( TS ) is approximately 20 cm shorter compared with healthy females .
Treatment with growth hormone ( GH ) increases the adult height of people with TS .
The effects of adding the and rogen , ox and rolone , in addition to GH are unclear .
Therefore , we conducted this systematic review to investigate the benefits and harms of ox and rolone as an adjuvant therapy for people with TS treated with GH .
OBJECTIVES To assess the effects of ox and rolone on growth hormone-treated girls aged up to 18 years with Turner syndrome .