RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .
Comparison of angiotensin II receptor blockers: impact of missed doses of candesartan cilexetil and losartan in systemic hypertension.
Blood pressure remains poorly controlled in the hypertensive population due in large part to low or unsatisfactory patient compliance . Clinical studies that incorporate an intentionally missed dose have been design ed to evaluate the impact of poor patient compliance on the effectiveness of antihypertensive medications . In these studies , ambulatory blood pressure monitoring is continued throughout the dosing interval and beyond in order to determine when systolic and diastolic blood pressure increase into the hypertensive range . In an 8-week , r and omized , double-blind , placebo-controlled trial in patients with mild-to-moderate hypertension , the antihypertensive effects of c and esartan cilexetil 16 mg were maintained after a missed dose , whereas systolic and diastolic blood pressure increased toward baseline levels after a missed dose of losartan 100 mg . C and esartan cilexetil provided a significantly greater reduction in sitting systolic ( p = 0.004 ) and diastolic blood pressure ( p = 0.008 ) than losartan when measured 48 hours after the last dose . Moreover , the homogeneity of antihypertensive effects was greater after c and esartan cilexetil than losartan based on calculation of the smoothness index from ambulatory systolic and diastolic measurements during the first 24-hour period after dosing and during the 12-hour period after the missed dose . These results demonstrate that missing or delaying a dose of c and esartan cilexetil has less impact on antihypertensive efficacy than missing or delaying a dose of losartan
RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .