Moderate hypofractionation is safe and effective , but longer-term data are still lacking .
Brachytherapy represents an effective way to increase the delivered dose .
OBJECTIVE To present a summary of the 2016 version of the European Association of Urology ( EAU ) - European Society for Radiotherapy & Oncology ( ESTRO ) - International Society of Geriatric Oncology ( SIOG ) Guidelines on screening , diagnosis , and local treatment with curative intent of clinical ly localised prostate cancer ( PCa ) .
EVIDENCE SYNTHESIS BRCA2 mutations have been added as risk factors for early and aggressive disease .
Systematic screening is still not recommended .
An early prostate-specific antigen test , the use of a risk calculator , or one of the promising biomarker tools are being investigated and might be able to limit the overdetection of insignificant PCa .
Breaking the link between diagnosis and treatment may lower the overtreatment risk .
Multiparametric magnetic resonance imaging using st and ardised reporting can not replace systematic biopsy , but robustly nested within the diagnostic work-up , it has a key role in local staging .
In Northern and Western Europe , the number of men diagnosed with PCa has been on the rise .
Complications and other surgical outcomes associated with extended pelvic lymphadenectomy in men with localized prostate cancer.
OBJECTIVES More-extensive pelvic lymph node dissection ( PLND ) may be associated with a higher rate of complications and a longer hospital stay than more limited PLND . METHODS Before radical retropubic prostatectomy , PLNDs were performed in 963 patients . Of these , 767 ( 79.6 % ) had > or=10 lymph nodes removed and examined ( extended PLND [ ePLND ] ) , while 1 - 9 nodes ( limited PLND [ lPLND ] ) were removed in the remaining 196 ( 20.4 % ) . Limits included external iliac , obturator , internal iliac , and iliac bifurcation . PLND-related  complications and the length of hospital stay were recorded prospect ively and analyzed according to the extent of PLND . RESULTS In patients subjected to ePLND , the overall rate of complications was 19.8 % versus 8.2 % in those treated with lPLND ( p<0.001 ) . In individual analyses of specific complications , only the lymphocele rate was significantly higher after ePLND ( 10.3 % vs 4.6 % ; p=0.01 ) . Similarly , ePLND translated into a longer hospital stay ( 9.9 vs 8.2 d ; p<0.001 ) . These differences persisted when adjustment was made for prostate-specific antigen and either clinical or pathologic tumor characteristics . CONCLUSIONS Our data indicate that , even in the h and s of experienced urologic surgeons , ePLNDs are associated with higher complication rates and longer hospital stay . These detriments need to be taken into account when the staging benefit associated with ePLND is considered
Moderate hypofractionation is safe and effective , but longer-term data are still lacking .
Brachytherapy represents an effective way to increase the delivered dose .
OBJECTIVE To present a summary of the 2016 version of the European Association of Urology ( EAU ) - European Society for Radiotherapy & Oncology ( ESTRO ) - International Society of Geriatric Oncology ( SIOG ) Guidelines on screening , diagnosis , and local treatment with curative intent of clinical ly localised prostate cancer ( PCa ) .
EVIDENCE SYNTHESIS BRCA2 mutations have been added as risk factors for early and aggressive disease .
Systematic screening is still not recommended .
An early prostate-specific antigen test , the use of a risk calculator , or one of the promising biomarker tools are being investigated and might be able to limit the overdetection of insignificant PCa .
Breaking the link between diagnosis and treatment may lower the overtreatment risk .
Multiparametric magnetic resonance imaging using st and ardised reporting can not replace systematic biopsy , but robustly nested within the diagnostic work-up , it has a key role in local staging .
In Northern and Western Europe , the number of men diagnosed with PCa has been on the rise .