In conclusion , Zinc supplementation  has favourable effects on plasma lipid parameters .
Zinc supplementation  significantly reduced total cholesterol , LDL cholesterol and triglycerides .
Therefore it may have the potential to reduce the incidence of atherosclerosis related morbidity and mortality
Zinc is a mineral that plays a vital role in many biological processes and plays an important role in insulin action and carbohydrate metabolism .
It may also have a protective role in the prevention of atherogenesis .
Numerous studies have evaluated the effects of Zinc supplementation on serum lipids in humans and have demonstrated varying results .
We systematic ally evaluated the literature and performed a meta- analysis on the effects of Zinc supplementation on serum lipids .
The effect of five-year zinc supplementation on serum zinc, serum cholesterol and hematocrit in persons randomly assigned to treatment group in the age-related eye disease study: AREDS Report No. 7.
The effects of long-term supplementation with pharmacologic doses of zinc oxide on serum levels of zinc , lipids and hematocrit have not been studied systematic ally to date . Eleven Clinical Centers enrolled 4757 participants from 1992 to 1998 as part of the Age-Related Eye Disease Study ( AREDS ) . Of these , 3640 participants , aged 55 - 80 y , who had early-to-late age-related macular degeneration ( AMD ) were r and omly assigned to daily supplementation with or without 80 mg of zinc as zinc oxide plus 2 mg of copper as cupric oxide to study the effects of zinc supplementation on the progression to late AMD . This paper reports on the effect of a 5-y supplementation with zinc oxide and cupric oxide on serum zinc , copper , lipids , and hematocrit for 717 participants from three clinical centers . At the 5-y exam , the median increase in serum zinc levels for participants assigned to zinc formulations was 17 % compared with a 2 % increase for participants not assigned to zinc ( P < 0.001 ) . The differential effect on serum zinc was observed at 1 y and remained fairly constant over the 5-y period . After 5 y , no significant differences in changes in serum hematocrit , copper or lipids were found between participants assigned to formulations containing zinc and copper , and those assigned to formulations without zinc and copper . Estimates from a modified Block Food-Frequency Question naire suggest the AREDS population at baseline had a zinc intake from diet similar to that of the general population
In conclusion , Zinc supplementation  has favourable effects on plasma lipid parameters .
Zinc supplementation  significantly reduced total cholesterol , LDL cholesterol and triglycerides .
Therefore it may have the potential to reduce the incidence of atherosclerosis related morbidity and mortality
Zinc is a mineral that plays a vital role in many biological processes and plays an important role in insulin action and carbohydrate metabolism .
It may also have a protective role in the prevention of atherogenesis .
Numerous studies have evaluated the effects of Zinc supplementation on serum lipids in humans and have demonstrated varying results .
We systematic ally evaluated the literature and performed a meta- analysis on the effects of Zinc supplementation on serum lipids .