Conclusions Short-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders
Background Fish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases , such as cardiovascular disease , type 2 diabetes and several types of cancers .
However , the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial .
This meta- analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aim ed to evaluate whether fish oil supplementation could improve insulin sensitivity .
A fish-based diet intervention improves endothelial function in postmenopausal women with type 2 diabetes mellitus: a randomized crossover trial.
OBJECTIVE The beneficial effects of fish and n-3 polyunsaturated fatty acids ( PUFAs ) consumption on atherosclerosis have been reported in numerous epidemiological studies . However , to the best of our knowledge , the effects of a fish-based diet intervention on endothelial function have not been investigated . Therefore , we studied these effects in postmenopausal women with type 2 diabetes mellitus ( T2DM ) . MATERIAL S/ METHODS Twenty-three postmenopausal women with T2DM were assigned to two four-week periods of either a fish-based diet ( n-3 PUFAs ≧ 3.0 g/day ) or a control diet in a r and omized crossover design . Endothelial function was measured with reactive hyperemia using strain-gauge plethysmography and compared with the serum levels of fatty acids and their metabolites . Endothelial function was determined with peak forearm blood flow ( Peak ) , duration of reactive hyperemia ( Duration ) and flow debt repayment ( FDR ) . RESULTS A fish-based dietary intervention  improved Peak by 63.7 % , Duration by 27.9 % and FDR by 70.7 % , compared to the control diet . Serum n-3 PUFA levels increased after the fish-based diet period and decreased after the control diet , compared with the baseline ( 1.49 vs. 0.97 vs. 1.19 mmol/l , p < 0.0001 ) . There was no correlation between serum n-3 PUFA levels and endothelial function . An increased ratio of epoxyeicosatrienoic acid/dihydroxyeicosatrienoic acid was observed after a fish-based diet intervention , possibly due to the inhibition of the activity of soluble epoxide hydrolase . CONCLUSIONS A fish-based dietary intervention  improves endothelial function in postmenopausal women with T2DM . Dissociation between the serum n-3 PUFA concentration and endothelial function suggests that the other factors may contribute to this phenomenon
Conclusions Short-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders
Background Fish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases , such as cardiovascular disease , type 2 diabetes and several types of cancers .
However , the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial .
This meta- analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aim ed to evaluate whether fish oil supplementation could improve insulin sensitivity .