The current meta- analysis revealed that probiotic supplementation may result in increasing TAC and lowering MDA , which improve antioxidant status .
Previous studies have supposed that probiotic supplementation led to a positive effect on different health outcomes .
Furthermore , several studies indicated that probiotics supplementation improved antioxidant status , while some studies did not indicate these effects .
Hence , current systematic review and meta- analysis study was conducted to determine the effect of probiotic supplementation on some oxidative stress biomarkers  among adult subjects .
Consumption of a Bifidobacterium bifidum Strain for 4 Weeks Modulates Dominant Intestinal Bacterial Taxa and Fecal Butyrate in Healthy Adults
ABSTRACT Modulation of the intestinal microbial ecosystem ( IME ) is a useful target to establish probiotic efficacy in a healthy population . We conducted a r and omized , double-blind , crossover , and placebo-controlled intervention study to determine the impact of Bifidobacterium bifidum strain Bb on the IME of adult healthy volunteers of both sexes .  High-throughput 16S rRNA gene sequencing was used to characterize the fecal microbiota before and after 4 weeks of daily probiotic cell consumption . The intake of approximately one billion live B. bifidum cells affected the relative abundance of dominant taxa in the fecal microbiota and modulated fecal butyrate levels . Specifically , Prevotellaceae ( P = 0.041 ) and Prevotella ( P = 0.034 ) were significantly decreased , whereas Ruminococcaceae ( P = 0.039 ) and Rikenellaceae ( P = 0.010 ) were significantly increased . We also observed that the probiotic intervention modulated the fecal concentrations of butyrate in a manner dependent on the initial levels of short-chain fatty acids ( SCFAs ) . In conclusion , our study demonstrates that a single daily administration of Bifidobacterium bifidum strain Bb can significantly modify the IME in healthy ( not diseased ) adults . These findings demonstrate the need to reassess the notion that probiotics do not influence the complex and stable IME of a healthy individual . IMPORTANCE Foods and supplements cl aim ed to contain health-promoting probiotic microorganisms are everywhere these days and mainly intended for consumption by healthy people . However , it is still debated what actual effects probiotic products may have on the healthy population . In this study , we report the results of an intervention trial aim ed at assessing the modifications induced in the intestinal microbial ecosystem of healthy adults from the consumption of a probiotic product . Our results demonstrate that the introduction of a probiotic product in the dietary habits of healthy people may significantly modify dominant taxa of the intestinal microbiota , result ing in the modulation of short-chain fatty acid concentrations in the gut . The overall changes witnessed in the probiotic intervention indicate a mechanism of microbiota modulation that could have potential effects on human health
The current meta- analysis revealed that probiotic supplementation may result in increasing TAC and lowering MDA , which improve antioxidant status .
Previous studies have supposed that probiotic supplementation led to a positive effect on different health outcomes .
Furthermore , several studies indicated that probiotics supplementation improved antioxidant status , while some studies did not indicate these effects .
Hence , current systematic review and meta- analysis study was conducted to determine the effect of probiotic supplementation on some oxidative stress biomarkers  among adult subjects .