The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Chronic dose-response curve of enalapril in essential hypertensives. An Italian multicenter study.
We have previously shown that enalapril , when given acutely to renovascular patients , exerted a dose-dependent hypotensive effect . To address the same problem in chronically treated essential hypertensives , we studied 116 uncomplicated essential hypertensives , whose diastolic blood pressure was greater than or equal to 95 mm Hg at the end of a two-week placebo run-in period ( time 0 ) . According to a r and omized crossover design , these patients received three doses ( 10 , 20 , or 40 mg ) of enalapril qd and a placebo , each treatment being given for one month . At the end of each treatment period as well as at time 0 , blood pressure and heart rate were measured 24 hours after the last dosing . In spite of a two-week run-in placebo period , placebo treatment further and significantly reduced blood pressure ; however enalapril further and significantly reduced blood pressure when compared to placebo . Although absolute blood pressure values after 40 mg of enalapril were significantly lower than those after 10 mg of enalapril the relevance of this difference , mainly when compared to placebo , seems to be inconsistent . Taken together these data suggest that the hypotensive effect of enalapril chronically given to essential hypertensives and measured 24 hours after last dosing , is dose independent
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .