In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .
Prone accelerated partial breast irradiation after breast-conserving surgery: preliminary clinical results and dose-volume histogram analysis.
PURPOSE To report the clinical and dose-volume histogram results of the first 47 patients accrued to a protocol of accelerated partial breast irradiation .  Patients were treated in the prone position with three-dimensional conformal radiotherapy after breast-conserving surgery . METHODS AND MATERIAL S Postmenopausal women with Stage T1N0 breast cancer were eligible only after they had first refused to undergo 6 weeks of st and ard radiotherapy . Planning CT in the prone position was performed on a dedicated table . The postoperative cavity was defined as the clinical target volume , with a 1.5-cm margin added to determine the planning target volume . A total dose of 30 Gy at 6 Gy/fraction was delivered in five fractions within 10 days . RESULTS The median age of the patients was 67.5 years ( range , 51 - 88 years ) . The median tumor diameter was 9 mm ( range , 1.3 - 19 mm ) . In all patients , the prescribed dose encompassed the planning target volume . The mean volume of the ipsilateral breast receiving 100 % of the prescription dose was 26 % ( range , 10 - 45 % ) , and the mean volume contained within the 50 % isodose surface was 47 % ( range , 23 - 75 % ) . The lung and heart were spared by treating in the prone position . Acute toxicity was modest , limited mainly to Grade 1 - 2 erythema . With a median follow-up of 18 months , only Grade 1 late toxicity occurred , and no patient developed local recurrence . CONCLUSION These data suggest that this approach is well tolerated , with only mild acute side effects and sparing of the heart and lung
In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .