R and omized controlled trials found a positive correlation for SB with BMI , neck circumference , fat mass , HbA1C , cholesterol and insulin levels , cohort studies additionally for WC , leptin , C-peptide , ApoA1 and Low density lipoprotein and a negative correlation for HDL .
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin .
OBJECTIVE Pathomechanisms of sedentary behaviour ( SB ) are unclear .
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults .
Physical activity attenuates age-related biomarker alterations in preclinical AD
Objective : To examine whether engagement in physical activity might favorably alter the age-dependent evolution of Alzheimer disease (AD)-related brain and cognitive changes in a cohort of at-risk , late-middle-aged adults . Methods : Three hundred seventeen enrollees in the Wisconsin Registry for Alzheimer 's Prevention underwent  T1 MRI ; a subset also underwent 11C-Pittsburgh compound B – PET ( n = 186 ) and 18F-fluorodeoxyglucose – PET ( n = 152 ) imaging . Participants ' responses on a self-report measure of current physical activity were used to classify them as either physically active or physically inactive based on American Heart Association guidelines . They also completed a comprehensive neuropsychological battery . Covariate-adjusted regression analyses were used to test whether the adverse effect of age on imaging and cognitive biomarkers was modified by physical activity . Results : There were significant age × physical activity interactions for β-amyloid burden ( p = 0.014 ) , glucose metabolism ( p = 0.015 ) , and hippocampal volume ( p = 0.025 ) such that , with advancing age , physically active individuals exhibited a lesser degree of biomarker alterations compared with the physically inactive . Similar age × physical activity interactions were also observed on cognitive domains of Immediate Memory ( p = 0.042 ) and Visuospatial Ability ( p = 0.016 ) . In addition , the physically active group had higher scores on Speed and Flexibility ( p = 0.002 ) compared with the inactive group . Conclusions : In a middle-aged , at-risk cohort , a physically active lifestyle is associated with an attenuation of the deleterious influence of age on key biomarkers of AD pathophysiology . However , because our observational , cross-sectional design can not establish causality , r and omized controlled trials/longitudinal studies will be necessary for determining whether midlife participation in structured physical exercise forestalls the development of AD and related disorders in later life
R and omized controlled trials found a positive correlation for SB with BMI , neck circumference , fat mass , HbA1C , cholesterol and insulin levels , cohort studies additionally for WC , leptin , C-peptide , ApoA1 and Low density lipoprotein and a negative correlation for HDL .
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin .
OBJECTIVE Pathomechanisms of sedentary behaviour ( SB ) are unclear .
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults .