Garlic reduces TC to a modest extent , an effect driven mostly by the modest reductions in TAG , without appreciable LDL lowering or HDL elevation .
Higher baseline line TC levels and the use of dietary modification may alter the effect of garlic on these parameters .
In order to determine the impact of  garlic on total cholesterol ( TC ) , TAG levels , as well as LDL and HDL  , and establish if any variables have an impact on the magnitude of this effect , a meta- analysis was conducted .
Lack of efficacy of dried garlic in patients with hyperlipoproteinemia.
The effects of dried garlic on blood lipids , apolipoproteins and blood coagulation parameters in hyperlipemic patients were studies in two controlled , r and omized , double-blind studies . Both studies comprised placebo and therapy periods of 6 weeks each . The doses administered were 3 X 198 mg in Study I ( 34 patients ) and 3 X 450 mg in Study II ( 51 patients ) . In both studies , the following serum parameters were measured every 3 weeks : total cholesterol , HDL ( high density lipoprotein)- and LDL ( low density lipoprotein)-cholesterol , triglycerides and several safety parameters . In addition , apolipoproteins A and B , euglobulin lysis time , fibrin split products , prothrombin time , whole blood coagulation time and fibrinogen levels were determined in the second study only . The results indicated that neither dosage of dried garlic showed any significant effect on any of the parameters measured . It is therefore concluded that , if there is any effect of garlic on the parameters measured , it is not apparent when using a dried preparation in the dosage studied
Garlic reduces TC to a modest extent , an effect driven mostly by the modest reductions in TAG , without appreciable LDL lowering or HDL elevation .
Higher baseline line TC levels and the use of dietary modification may alter the effect of garlic on these parameters .
In order to determine the impact of  garlic on total cholesterol ( TC ) , TAG levels , as well as LDL and HDL  , and establish if any variables have an impact on the magnitude of this effect , a meta- analysis was conducted .