Multiple secondary data analyses of TORDIA have identified important predictors of treatment response and relapse .
To up date a comparative effectiveness review ( 1980–2011 ) of treatments for adolescents whose depressive episode or disorder ( MDE/MDD ) did not respond to one or more trials of SSRI antidepressants .
Predictors and moderators of acute outcome in the Treatment for Adolescents with Depression Study (TADS).
OBJECTIVE To identify predictors and moderators of response to acute treatments among depressed adolescents ( N = 439 ) r and omly assigned to fluoxetine , cognitive-behavioral therapy ( CBT ) , both fluoxetine and CBT , or clinical management with pill placebo in the Treatment for Adolescents With Depression Study ( TADS ) . METHOD Potential baseline predictors and moderators were identified by a literature review . The outcome measure was a week 12 predicted score derived from the Children 's Depression Rating Scale-Revised ( CDRS-R ) . For each c and i date moderator or predictor , a general linear model was conducted to examine main and interactive effects of treatment and the c and i date variable on the CDRS-R predicted scores . RESULTS Adolescents who were younger , less chronically depressed , higher functioning , and less hopeless with less suicidal ideation  , fewer melancholic features or comorbid diagnoses , and greater expectations for improvement were more likely to benefit acutely than their counterparts . Combined treatment , under no condition less effective than monotherapy , was more effective than fluoxetine for mild to moderate depression and for depression with high levels of cognitive distortion , but not for severe depression or depression with low levels of cognitive distortion .  Adolescents from high-income families were as likely to benefit from CBT alone as from combined treatment . CONCLUSIONS Younger and less severely impaired adolescents are likely to respond better to acute treatment than older , more impaired , or multiply comorbid adolescents .  Family income level , cognitive distortions , and severity of depression may help clinicians to choose among acute interventions , but combined treatment proved robust in the presence of moderators
Multiple secondary data analyses of TORDIA have identified important predictors of treatment response and relapse .
To up date a comparative effectiveness review ( 1980–2011 ) of treatments for adolescents whose depressive episode or disorder ( MDE/MDD ) did not respond to one or more trials of SSRI antidepressants .