Results : Duloxetine may be an effective treatment for mood spectrum disorders , panic disorder , several symptom clusters of borderline personality , and as add-on drug in schizophrenia .
Modest or conflicting results have been found for the efficacy of duloxetine in obsessive-compulsive disorder , posttraumatic stress disorder , eating , and sexual disorders .
Background : Duloxetine hydrochloride ( DUL ) is an antidepressant included in the pharmacological class of serotonin-norepinephrine reuptake inhibitors approved for the treatment of major depressive disorder , generalized anxiety disorder , diabetic peripheral neuropathic pain , fibromyalgia , and chronic musculoskeletal pain .
The aim of this review was to eluci date current evidence s on the use of DUL in the treatment of a variety of psychiatric disorders .
Treatment of seasonal affective disorder with duloxetine: an open-label study.
OBJECTIVE The aim of this observational study was to evaluate the effects of duloxetine in the treatment of seasonal affective disorder ( SAD ) . PATIENTS AND METHODS 26 SAD patients were treated with open-label duloxetine 60 - 120 mg per day over 8 weeks . Ratings included the Structured Interview Guide for the Hamilton Depression Rating Scale ( SAD version ; SIGH-SAD ) and the Clinical Global Impression ( CGI ) . To estimate treatment effects on social functioning in SAD we employed the Social Adaptation Self Evaluation Scale ( SASS ) , the Sheehan Disability Scale ( SDS ) , and assessment s of days lost due to illness and days with reduction in productivity . RESULTS Duloxetine led to a significant improvement ( p<0.001 ) of SIGH-SAD , CGI severity , SASS , and SDS scores . Days lost due to illness and days with reduction in productivity were significantly diminished during treatment ( p<0.001 ) . Treatment with duloxetine over 8 weeks yielded a response rate ( SIGH-SAD<50 % of baseline value ) of 80.8 % and a remission rate ( SIGH-SAD<8 ) of 76.9 % in the intention to treat sample . The drop-out rate due to side effects was 15.4 % . CONCLUSIONS Our preliminary results indicate that duloxetine might be effective and able to ameliorate the negative social consequences of SAD
Results : Duloxetine may be an effective treatment for mood spectrum disorders , panic disorder , several symptom clusters of borderline personality , and as add-on drug in schizophrenia .
Modest or conflicting results have been found for the efficacy of duloxetine in obsessive-compulsive disorder , posttraumatic stress disorder , eating , and sexual disorders .
Background : Duloxetine hydrochloride ( DUL ) is an antidepressant included in the pharmacological class of serotonin-norepinephrine reuptake inhibitors approved for the treatment of major depressive disorder , generalized anxiety disorder , diabetic peripheral neuropathic pain , fibromyalgia , and chronic musculoskeletal pain .
The aim of this review was to eluci date current evidence s on the use of DUL in the treatment of a variety of psychiatric disorders .