This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .
Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans
Background : The A risk allele of rs9939609 of the fat mass- and obesity-associated gene ( FTO ) increases body fat mass . Objective : To examine whether FTO rs9939609 affects obese individuals ' response to a high-fat , low-carbohydrate ( CHO ) ( HF ) or low-fat , high-CHO ( LF ) , hypo-energetic diet and whether the effect of the FTO variant depends on dietary fat and CHO content . Design : In a 10-week , European , multi-centre dietary intervention study 771 obese women and men were r and omized to either LF ( 20–25 % of energy ( % E ) from fat , 60–65%E from CHO ) or HF ( 40–45%E from fat , 40–45%E from CHO ) , hypo-energetic diet ( measured resting metabolic rate multiplied by 1.3–600 kcal day−1 ) . Body weight , fat mass ( FM ) , fat-free mass ( FFM ) , waist circumference ( WC ) , resting energy expenditure ( REE ) , fasting fat oxidation as % of REE ( FatOx ) , insulin release ( HOMA-β ) and a surrogate measure of insulin resistance ( HOMA-IR ) were measured at baseline and after the intervention . In all , 764 individuals were genotyped for FTO rs9939609 . Results : For A-allele carriers the drop-out rate was higher on HF than LF diet ( in AT , P=0.002 ; in AT/AA combined , P=0.003 ) . Among those individuals completing the intervention , we found no effect of FTO rs9939609 genotype on Δweight , ΔFM , ΔFFM , ΔWC or ΔFatOx . However , participants with TT had a smaller reduction in REE on LF than on HF diet ( 75 kcal/24 h ; interaction : P=0.0055 ) . These individuals also showed the greatest reduction in HOMA-β and HOMA-IR ( interaction : P=0.0083 and P=0.047 ) . Conclusion : The FTO rs9939609 may interact with the macronutrient composition in weight loss diets in various ways ; carriers of the A allele on LF diet appear to have a lower risk for drop out , and TT individuals have a smaller decrease in REE and greater decrease in HOMA-β and HOMA-IR on LF than on HF diet
This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .