Free fatty acid supplementation produced small but significant reductions in ADHD symptoms even with probably blinded assessment s , although the clinical significance of these effects remains to be determined .
Artificial food color exclusion produced larger effects but often in individuals selected for food sensitivities .
OBJECTIVE Nonpharmacological treatments are available for attention deficit hyperactivity disorder ( ADHD ) , although their efficacy remains uncertain .
The authors undertook meta-analyses of the efficacy of dietary ( restricted elimination diets , artificial food color exclusions , and free fatty acid supplementation ) and psychological ( cognitive training , neurofeedback , and behavioral interventions ) ADHD treatments .
The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: a double-blind placebo-controlled trial, followed by an open-label extension.
OBJECTIVE To study the efficacy and safety of phosphatidylserine ( PS ) containing Omega3 long-chain polyunsaturated fatty acids attached to its backbone ( PS-Omega3 ) in reducing attention-deficit/ hyperactivity disorder ( ADHD ) symptoms in children . METHOD A 15-week , double-blind , placebo-controlled phase followed by an open-label extension of additional 15 weeks . Two hundred ADHD children were r and omized to receive either PS-Omega3 or placebo , out of them , 150 children continued into the extension .  Efficacy was assessed using Conners ' parent and teacher rating scales ( CRS-P , T ) , Strengths and Difficulties Question naire ( SDQ ) , and Child Health Question naire ( CHQ ) . Safety evaluation included adverse events monitoring . RESULTS The key finding of the double-blind phase was the significant reduction in the Global : Restless/impulsive subscale of CRS-P and the significant improvement in Parent impact-emotional ( PE ) subscale of the CHQ , both in the PS-Omega3 group . Exploratory subgroup analysis of children with a more pronounced hyperactive/impulsive behavior , as well as mood and behavior-dysregulation , revealed a significant reduction in the ADHD-Index and hyperactive components . Data from the open-label extension indicated sustained efficacy for children who continued to receive PS-Omega3 . Children that switched to PS-Omega3 treatment from placebo showed a significant reduction in subscales scores of both CRS-P and the CRS-T , as compare to baseline scores . The treatment was well tolerated . CONCLUSIONS The results of this 30-week study suggest that PS-Omega3 may reduce ADHD symptoms in children . Preliminary analysis suggests that this treatment may be especially effective in a subgroup of hyperactive-impulsive , emotionally and behaviorally-dysregulated ADHD children
Free fatty acid supplementation produced small but significant reductions in ADHD symptoms even with probably blinded assessment s , although the clinical significance of these effects remains to be determined .
Artificial food color exclusion produced larger effects but often in individuals selected for food sensitivities .
OBJECTIVE Nonpharmacological treatments are available for attention deficit hyperactivity disorder ( ADHD ) , although their efficacy remains uncertain .
The authors undertook meta-analyses of the efficacy of dietary ( restricted elimination diets , artificial food color exclusions , and free fatty acid supplementation ) and psychological ( cognitive training , neurofeedback , and behavioral interventions ) ADHD treatments .