There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Effects of diet on the lipid and fatty acid status of full-term infants at 4 months.
OBJECTIVE To compare the effects of the exogenous supply of long-chain polyunsaturated fatty acids ( LCP ) and cholesterol on the lipid and fatty acid status in full-term , 4-month old infants . METHODS Twenty-three infants received a st and ard infant formula  while twenty-one were given a formula enriched with LCP and cholesterol in a prospect i ve , r and omized study . The composition of the two formulas differed only in fat quality . A group of fifteen breastfed infants fed was used as reference . No one was complemented with solid foods before blood sampling at 4 months of life . RESULTS Differences in total-cholesterol and low-density lipoprotein-cholesterol ( LDL-C ) levels between feeding groups were mainly gender-related . Dietary cholesterol tended to increase LDL-C plasma levels . The breastfed and the enriched formula-fed groups had higher levels of circulating LCP than the group that received the st and ard formula . In the erythrocytes of infants fed the st and ard formula , C22:6 n-3 levels were less than 50 % those of the breastfed and the enriched formula-fed ones . Higher C20:4 n-6 levels were found in the erythrocytes of the enriched formula-fed group . CONCLUSIONS Formula-fed , full-term infants maintain a lipid and fatty acid status close to that of breastfed infants when supplied with dietary LCP and cholesterol
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .