Collectively , the literature reveals pre clinical and clinical evidence for various phytomedicines modulating GABA-pathways , with comparative anxiolytic effect to the current array of pharmaceuticals , along with good safety and tolerability profiles
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress , characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia .
Gamma-aminobutyric acid ( GABA ) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety .
Although current pharmaceutical treatments are often efficacious , they may cause undesirable side effects including cognitive decrements and withdrawal symptoms .
Plant-based " phytomedicines " may provide novel treatment options , to act as an adjunctive or alternative to existing anxiolytic medications .
As such , we conducted a systematic review to assess the current body of literature on anxiolytic phytomedicines and /or phytoconstituents .
The Efficacy of Passiflora Incarnata Linnaeus in Reducing Dental Anxiety in Patients Undergoing Periodontal Treatment
Statement of Problem : Oral premedication used to reduce the anxiety in patients undergoing dental treatment .  Passion flower has been used as a sedative that can control the dental anxiety . Purpose : This study determines the efficacy of Passion flower , in reducing anxiety during the dental procedures . Material and Methods : In this r and omized- one sided blind clinical trial , 63 patients , with moderate , high and severe anxiety(according to VAS score ) in need of periodontal treatment were r and omly divided into 3 groups of 21.The first group was given the drop Passion flower drop and the second group were given the drop of placebo and the third group ; neither drug nor placebo were given ( negative control group ) . Results were analyzed by Chi Square , Variance Analysis , Tucky and Paired-T using SPSS software . Results : Mean anxiety level prior to the drug administration was 12.09±2.42 for the Passion flower group , 12.00±2.66 for the placebo group and 11.66±2.39 for the negative control group . After premedication , these values were : 8.47±2.58 for the Passion flower group , 10.52±2.11 for the placebo group and 11.23±2.34 for the negative control group . These results demonstrated a significant difference ( p < 0.0001 ) in the anxiety levels before and after the Passion flower administration in the Passion flower group and also between the Passion flower group and the other two groups . Conclusion : Results indicated that administration of Passion flower , as a premedication , is significantly effective in reducing the anxiety . Since this study is a pioneer on the subject , further trials with greater number of subjects are required to confirm our results
Collectively , the literature reveals pre clinical and clinical evidence for various phytomedicines modulating GABA-pathways , with comparative anxiolytic effect to the current array of pharmaceuticals , along with good safety and tolerability profiles
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress , characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia .
Gamma-aminobutyric acid ( GABA ) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety .
Although current pharmaceutical treatments are often efficacious , they may cause undesirable side effects including cognitive decrements and withdrawal symptoms .
Plant-based " phytomedicines " may provide novel treatment options , to act as an adjunctive or alternative to existing anxiolytic medications .
As such , we conducted a systematic review to assess the current body of literature on anxiolytic phytomedicines and /or phytoconstituents .