Azapirones may be less effective than benzodiazepines and we were unable to conclude if azapirones were superior to antidepressants , kava kava or psychotherapy .
Azapirones appeared to be well tolerated .
Azapirones appeared to be useful in the treatment of GAD , particularly for those participants who had not been on a benzodiazepine .
Azapirones may not be superior to benzodiazepines and do not appear as acceptable as benzodiazepines .
Side effects appeared mild and non serious in the azapirone treated group .
Longer term studies are needed to show that azapirones are effective in treating GAD , which is a chronic long-term illness
BACKGROUND Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from generalized anxiety disorder ( GAD ) .
However , several studies have shown conflicting results .
Whether azapirones are useful as first line treatment in general anxiety disorders still needs to be answered .
OBJECTIVES To assess the efficacy and the acceptability of azapirones for the treatment of GAD .
Kava-Kava extract LI 150 is as effective as Opipramol and Buspirone in Generalised Anxiety Disorder--an 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients.
OBJECTIVE An 8-week r and omized , reference-controlled , double-blind , multi-centre clinical trial investigated Kava-Kava LI 150 in Generalized Anxiety Disorder ( GAD ; ICD-10 : F41.1 ) . METHOD 129 out- patients received either 400 mg Kava LI 150 , 10 mg Buspirone or 100 mg Opipramol daily for 8 weeks . At week 9 , subjects were seen to check for symptoms of withdrawal or relapse . Primary outcome measures comprised the HAMA scale and the proportion of responders at week 8 . Secondary measures were the Boerner Anxiety Scale ( BOEAS ) , SAS , CGI , a self-rating scale for well-being ( Bf-S ) , a sleep question naire ( SF-B ) , a quality -of-life question naire ( AL ) and global judgements by investigator and patients . RESULTS In 127 patients ( ITT ) no significant differences could be observed regarding all efficacy and safety measures . About 75 % of patients were classified as responders ( 50 % reduction of HAMA score ) in each treatment group , about 60 % achieved full remission . CONCLUSION Kava-Kava LI150 is well tolerated and as effective as Buspirone and Opipramol in the acute treatment of out- patients suffering from GAD
Azapirones may be less effective than benzodiazepines and we were unable to conclude if azapirones were superior to antidepressants , kava kava or psychotherapy .
Azapirones appeared to be well tolerated .
Azapirones appeared to be useful in the treatment of GAD , particularly for those participants who had not been on a benzodiazepine .
Azapirones may not be superior to benzodiazepines and do not appear as acceptable as benzodiazepines .
Side effects appeared mild and non serious in the azapirone treated group .
Longer term studies are needed to show that azapirones are effective in treating GAD , which is a chronic long-term illness
BACKGROUND Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from generalized anxiety disorder ( GAD ) .
However , several studies have shown conflicting results .
Whether azapirones are useful as first line treatment in general anxiety disorders still needs to be answered .
OBJECTIVES To assess the efficacy and the acceptability of azapirones for the treatment of GAD .