AUTHORS ' CONCLUSIONS Addition of ox and rolone to the GH therapy led to a modest increase in the final adult height of girls aged up to 18 years with TS .
BACKGROUND The final adult height of untreated girls aged up to 18 years with Turner syndrome ( TS ) is approximately 20 cm shorter compared with healthy females .
Treatment with growth hormone ( GH ) increases the adult height of people with TS .
The effects of adding the and rogen , ox and rolone , in addition to GH are unclear .
Therefore , we conducted this systematic review to investigate the benefits and harms of ox and rolone as an adjuvant therapy for people with TS treated with GH .
OBJECTIVES To assess the effects of ox and rolone on growth hormone-treated girls aged up to 18 years with Turner syndrome .
Short-term growth hormone treatment in girls with Turner syndrome decreases fat mass and insulin sensitivity: a randomized, double-blind, placebo-controlled, crossover study.
BACKGROUND Most girls with Turner syndrome ( TS ) receive growth hormone ( GH ) treatment during childhood and adolescence , but controlled data on the effects on body composition and glucose metabolism are lacking . OBJECTIVE To study the effects of GH treatment on insulin sensitivity , glucose metabolism , bone turnover , and body composition . METHODS A r and omized , placebo-controlled , crossover study was conducted with girls with TS . All girls with TS were treated with GH 0.1 IU/kg/d subcutaneously at bedtime or with placebo for 2 months and studied at the end of each period . Control subjects were studied once without treatment . Twelve girls with TS , aged 9.5 to 14.8 years ( median : 12.9 years ) and 16 age-matched control subjects ( 10.3 - 16.0 years ; median : 12.1 years ) were studied . Twenty-four-hour sampling of blood was performed ; GH , insulin-like growth factor I ( IGF-I ) , IGF binding proteins ( IGFBPs ) , insulin , glucose , and lipolytic and gluconeogenic precursors were assayed , followed by an oral glucose tolerance test . Body composition was evaluated by dual-energy x-ray absorptiometry scanning and body mass index ( BMI ) . Fasting bone markers were measured . RESULTS Height was reduced in TS as compared with control subjects . In the placebo situation , 24-hour integrated GH as well as IGF-I was significantly reduced in girls with TS compared with control subjects . Controlling for differences in lean body mass ( LBM ; or fat mass [ FM ] ) and sexual development did not explain the difference in 24-hour integrated GH . Differences in sexual development , BMI , FM , insulin sensitivity , and IGFBP-3 could explain the difference in IGF-I between TS and control subjects . Carbohydrate metabolism in TS was comparable with control subjects . GH treatment induced insulin resistance , with increments in fasting glucose and insulin , as well as 24-hour insulin . Circulating levels of lipid and gluconeogenic substrates were comparable in TS and control subjects and unchanged in response to treatment . Bone markers increased in response to GH . Total FM was increased in girls with TS , accounted for by an increased FM in the arms and trunk , whereas LBM was decreased . Especially LBM in the legs was decreased . Overall , bone mineral content was diminished . Treatment with GH reduced FM in TS , especially in the arms and legs , and likewise increased total LBM , primarily in the trunk . CONCLUSION This study documented evidence of impaired GH secretion and action , disproportionate body composition , but a normal carbohydrate metabolism in girls with TS . Short-term GH administration was associated with favorable changes in body composition but also with relative impairment of glucose tolerance and insulin sensitivity . We recommend that glucose metabolism be monitored carefully during long-term GH treatment in these patients
AUTHORS ' CONCLUSIONS Addition of ox and rolone to the GH therapy led to a modest increase in the final adult height of girls aged up to 18 years with TS .
BACKGROUND The final adult height of untreated girls aged up to 18 years with Turner syndrome ( TS ) is approximately 20 cm shorter compared with healthy females .
Treatment with growth hormone ( GH ) increases the adult height of people with TS .
The effects of adding the and rogen , ox and rolone , in addition to GH are unclear .
Therefore , we conducted this systematic review to investigate the benefits and harms of ox and rolone as an adjuvant therapy for people with TS treated with GH .
OBJECTIVES To assess the effects of ox and rolone on growth hormone-treated girls aged up to 18 years with Turner syndrome .