Conclusion Our results indicate  that L-carnitine  reduced inflammatory mediators , especially in studies with a duration of more than 12 weeks .
Aim and background Reducing inflammation by nutritional supplements may help to reduce the risk of many chronic diseases .
Our aim in this meta- analysis was to determine the effect of L-carnitine on inflammatory mediators including C-reactive protein ( CRP ) , tumor necrosis factor-α ( TNF-α ) , and interleukin-6 ( IL-6 ) .
Antiinflammatory effects of L-carnitine supplementation (1000 mg/d) in coronary artery disease patients.
OBJECTIVE Inflammation mediators have been recognized as risk factors for the pathogenesis of coronary artery disease ( CAD ) . The purpose of this study was to investigate the effect of L-carnitine supplementation ( LC , 1000 mg/d ) on inflammation markers in patients with CAD . METHODS We enrolled 47 patients with CAD in the study . The patients with CAD were identified by cardiac catheterization as having < 50 % stenosis of one major coronary artery . The patients were r and omly assigned to the placebo ( n = 24 ) and LC ( n = 23 ) groups and the intervention was administered for 12 wk . The levels of LC , antioxidant status ( malondialdehyde and antioxidant enzymes activities ) , and inflammation markers ( C-reactive protein [ CRP ] , interleukin [IL]-6 , and tumor necrosis factor [TNF]-α ) were measured . RESULTS Thirty-nine participants completed the study ( 19 placebo ; 20 LC ) . After LC supplementation , the levels of inflammation markers were significantly reduced compared with the baseline ( CRP , P < 0.01 ; IL-6 , P = 0.03 ; TNF-α , P = 0.07 ) and those in the placebo group ( CRP , P < 0.05 ; IL-6 , P = 0.04 ; TNF-α , P = 0.03 ) . The levels of inflammation markers were significantly negatively correlated with the levels of LC and antioxidant enzymes activities ( P < 0.05 ) . CONCLUSIONS We suggest that LC supplementation , due to its antioxidant effects , may have potential utility to reduce inflammation in CAD
Conclusion Our results indicate  that L-carnitine  reduced inflammatory mediators , especially in studies with a duration of more than 12 weeks .
Aim and background Reducing inflammation by nutritional supplements may help to reduce the risk of many chronic diseases .
Our aim in this meta- analysis was to determine the effect of L-carnitine on inflammatory mediators including C-reactive protein ( CRP ) , tumor necrosis factor-α ( TNF-α ) , and interleukin-6 ( IL-6 ) .