In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .
Aspartame and sucrose produce a similar increase in the plasma phenylalanine to large neutral amino acid ratio in healthy subjects.
Aspartame ( L-aspartyl-L-phenylalanine methyl ester ) consumption has been postulated to increase brain phenylalanine levels by increasing the molar ratio of the plasma phenylalanine concentration to the sum of the plasma concentrations of the other large neutral amino acids ( Phe/LNAA ) . Dietary manipulations with carbohydrate or protein can also produce changes in the Phe/LNAA value . To compare the effects of aspartame and carbohydrate on Phe/LNAA , beverages sweetened with aspartame , sucrose , and aspartame plus sucrose , and unsweetened beverage were ingested by 8 healthy , fasted subjects in a r and omized , four-way crossover design . The beverages were sweetened with an amount of aspartame ( 500 mg ) and /or sucrose ( 100 g ) approximately equivalent to that used to sweeten 1 liter of soft drink . The baseline-corrected plasma Phe/LNAA values did not differ significantly following ingestion of aspartame or sucrose . Following aspartame alone , the high mean ratio increased 26 % over baseline 1 h after ingestion . Following sucrose alone , the high mean ratio increased 19 % at 2.5 h. Sucrose increased the Phe/LNAA value due to an insulin-mediated decrease in the plasma LNAA , while aspartame increased the ratio by increasing the plasma Phe concentration . These findings indicate that similar increases in plasma Phe/LNAA occur when healthy , fasting subjects ingest amounts of equivalent sweetness of sucrose or aspartame
In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .