Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Maternal vitamin D supplementation in pregnancy and offspring outcomes: a double-blind randomized placebo-controlled trial
We studied bone mineral content ( BMC ) , bone mineral density ( BMD ) , and body composition in offspring of women supplemented with vitamin D during pregnancy . Pregnant women were r and omized to receive oral cholecalciferol 60,000 units 4 weekly ( group 1 ) , 8 weekly ( group 2 ) , or placebo ( group 3 ) . All received 1 g calcium daily ( groups 1 and 2 without , and group 3 with 400 units vitamin D ) . Offspring at 12–16 months underwent dual-energy X-ray absorptiometry .  Maternal hypovitaminosis D  at recruitment was common ( serum 25OHD < 50 nmol/L in 88 % ) and severe ( 25OHD < 25 nmol/L in 46 % ) . Groups 1 and 2 ( n = 23 and 13 , median age 14 months ) had higher cord blood 25OHD ( 47.8 ± 13.8 and 31.0 ± 14.0 nmol/L ) versus group 3 ( n = 16 , median age 16 months , 17.8 ± 13.5 nmol/L , p < 0.001 ) . Babies in group 3 had higher whole-body BMC ( 250.8 ± 42.5 gm ) and BMD ( 0.335 ± 0.033 gm/cm2 ) compared to group 1 ( 213.1 ± 46.2 gm and 0.295 ± 0.041 gm/cm2 ) and group 2 ( 202.9 ± 29.9 gm and 0.287 ± 0.023 gm/cm2 ) ( p = 0.006 and 0.001 , respectively ) . In multivariate analysis , age , weight z score , and lean body mass remained significant contributors to BMC . Parameters of body composition were comparable among the groups . Vitamin D supplementation to pregnant women with severe deficiency in doses that improved cord blood 25OHD did not result in improved bone health or body composition in offspring at 12–16 months , compared to a dose too small to improve 25OHD levels
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .