Higher circulating concentrations of insulin , leptin , cholecystokinin and peptide-YY accord with reduced appetite and energy intakes in healthy older adults .
Interventions to reduce circulating levels of these hormones may be beneficial for combatting the anorexia of ageing
Ageing is associated with reduced appetite and energy intakes .
However , the mechanisms underlying this phenomenon are not fully understood .
This systematic review and meta- analysis quantified differences in circulating concentrations of appetite-related hormones between healthy older and younger adults .
Weekly subcutaneous pegylated recombinant native human leptin (PEG-OB) administration in obese men.
To assess the biological activity and tolerability of pegylated recombinant native human leptin ( PEG-OB ) , 30 obese men ( mean body mass index , 33.9 kg/m2 ) were r and omized to a double-blind treatment with weekly sc injections of 20 mg PEG-OB or placebo for 12 weeks , in addition to a hypocaloric diet ( deficit , 2 MJ/day ) . Body composition , energy expenditure , and metabolic parameters were measured before and after treatment . PEG-OB was generally well tolerated based on adverse event reports , lab values , and vital signs . Weekly sc PEG-OB led to sustained serum concentrations of PEG-OB and leptin throughout treatment . No significant differences in the delta or percent weight loss , percent body fat , sleeping metabolic rate , or respiratory quotient were observed between the PEG-OB and placebo groups . Percent change in serum triglycerides from baseline was significantly correlated with body weight loss in the PEG-OB group , but not in the placebo group . Although larger reductions in serum triglycerides were observed in the PEG-OB group compared with the placebo group , these differences were not statistically significant . We concluded that weekly injection of PEG-OB leads to sustained serum concentration of PEG-OB and leptin throughout the 12-week treatment period and is generally well tolerated . The trends observed in serum triglycerides suggest that a weekly 20-mg sc treatment with PEG-OB may have biological effects in obese men
Higher circulating concentrations of insulin , leptin , cholecystokinin and peptide-YY accord with reduced appetite and energy intakes in healthy older adults .
Interventions to reduce circulating levels of these hormones may be beneficial for combatting the anorexia of ageing
Ageing is associated with reduced appetite and energy intakes .
However , the mechanisms underlying this phenomenon are not fully understood .
This systematic review and meta- analysis quantified differences in circulating concentrations of appetite-related hormones between healthy older and younger adults .