However , it can significantly decrease postintervention and reduction data of FPG , FI , HbA1c , and HOMA-IR .
Heterogeneity was eliminated by subgroup analysis according to baseline BMI .
There was no significant difference in the amelioration of QUICKI between the ITC and control groups .
However , the difference was statistically significant and the heterogeneity was eliminated after subgroup analysis according to intakes of ITC .
Conclusion Supplementation of ITC can ameliorate IR in T2DM , especially in obese T2DM patients , but the effects are controversial in obese patients
Background Insulin resistance ( IR ) is a physiological condition related to type 2 diabetes mellitus ( T2DM ) and obesity , which is associated with high blood insulin and glucose .
Inulin-type carbohydrate ( ITC ) is a kind of fermentable fructan that can reduce glucose and ameliorate IR in an animal model , but the effect in clinical trials is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of ITC supplementation in ameliorating IR in T2DM and obese patients .
Milk Powder Co‐Supplemented with Inulin and Resistant Dextrin Improves Glycemic Control and Insulin Resistance in Elderly Type 2 Diabetes Mellitus: A 12‐Week Randomized, Double‐Blind, Placebo‐Controlled Trial
SCOPE The objective of the present study is to evaluate the effects of milk powder co-supplemented with inulin and resistant dextrin ( MPCIR ) on elderly patients with type 2 diabetes mellitus ( T2DM ) . METHODS AND RESULTS A r and omized , double-blind , placebo-controlled clinical trial is carried out among elderly T2DM patients . The subjects recruited from the community are r and omly assigned to either the MPCIR group or placebo group for 12 weeks intervention . Each group receives 45 g milk powder with or without inulin and resistant dextrin .  Anthropometric and metabolic variables are measured . For the MPCIR group , systolic blood pressure ( BP ) and diastolic BP are reduced significantly by 5.45 and 4.56 mm Hg ( p < 0.001 , vs placebo group ) , respectively . Compared with the placebo group , the fasting and 2-h postpr and ial plasma glucose levels , glycosylated serum protein , and insulin resistance index of the MPCIR group are significantly decreased by 0.96 mmol L-1 , 1.47 mmol L-1 , 16.33 μmol L-1 , and 0.65 respectively ( p < 0.001 ) . The MPCIR group shows an increase by 7.09 μIU mL-1 and 20.43 in 2-h postpr and ial insulin ( p = 0.016 ) and β-cell function index ( p < 0.001 ) , respectively . CONCLUSION MPCIR supplementation helps to improve glycemic control , insulin resistance , and blood pressure
However , it can significantly decrease postintervention and reduction data of FPG , FI , HbA1c , and HOMA-IR .
Heterogeneity was eliminated by subgroup analysis according to baseline BMI .
There was no significant difference in the amelioration of QUICKI between the ITC and control groups .
However , the difference was statistically significant and the heterogeneity was eliminated after subgroup analysis according to intakes of ITC .
Conclusion Supplementation of ITC can ameliorate IR in T2DM , especially in obese T2DM patients , but the effects are controversial in obese patients
Background Insulin resistance ( IR ) is a physiological condition related to type 2 diabetes mellitus ( T2DM ) and obesity , which is associated with high blood insulin and glucose .
Inulin-type carbohydrate ( ITC ) is a kind of fermentable fructan that can reduce glucose and ameliorate IR in an animal model , but the effect in clinical trials is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of ITC supplementation in ameliorating IR in T2DM and obese patients .