There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years.
BACKGROUND The Childhood Asthma Prevention Study was a r and omized controlled trial conducted in children with a family history of asthma in whom  omega-3 fatty acid supplementation and restriction of dietary omega-6 fatty acids did not prevent asthma , eczema , or atopy at age 5 years . OBJECTIVE We sought to examine the relation of all measures of omega-3 and omega-6 polyunsaturated fatty acids with outcomes at age 5 years in the whole birth cohort , regardless of r and omization group . METHODS Plasma fatty acids were measured at 18 months , 3 years , and 5 years . Compliance with the fatty acid supplements was estimated every 6 months . Dietary intake  was assessed at 18 months by means of weighed-food record and at 3 years by means of food-frequency question naire . At age 5 years , 516 children were examined for wheeze and eczema  ( question naire ) and atopy ( skin prick tests , n = 488 ) . Multiple logistic regression was used to evaluate associations between exposures and outcomes . RESULTS Plasma levels of omega-3 or omega-6 fatty acids were not associated with wheeze , eczema , or atopy at age 5 years ( P = .11-.96 ) . Overall , fatty acid exposure , measured as plasma levels , dietary intake , and compliance with supplements , was not associated with any respiratory or allergic outcomes ( P = .35-.59 ) . CONCLUSION This observational analysis of the cohort , using the full range of observed variation in omega-3 and omega-6 fatty acid exposure , supports the negative findings of the r and omized controlled trial . CLINICAL IMPLICATION S Modification of dietary polyunsaturated fatty acids in early childhood is not helpful in preventing atopy and asthma
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .