Conclusion Our findings may encourage curcumin supplementation based on its meaningful effect on glycemic control and positive trend on lipid outcomes in prediabetes and T2DM
Scope Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus ( T2DM ) .
This study aim ed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM .
Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study
Abstract Objective .  End-stage renal disease ( ESRD )  due to type 2 diabetic nephropathy is a very common condition which is increasing in prevalence , and is associated with high global levels of mortality and morbidity . Both proteinuria and transforming growth factor-β ( TGF-β ) may contribute to the development of ESRD in patients with diabetic nephropathy . Experimental studies indicate that turmeric improves diabetic nephropathy by suppressing TGF-β . Therefore , this study investigated the effects of turmeric on serum and urinary TGF-β , interleukin-8 ( IL-8 ) and tumour necrosis factor-α ( TNF-α ) , as well as proteinuria , in patients with overt type 2 diabetic nephropathy . Material and methods . A r and omized , double-blind and placebo-controlled study was carried out in the Diabetes Clinic of the Outpatient Department of Shiraz University of Medical Sciences on 40 patients with overt type 2 diabetic nephropathy , r and omized into a trial group ( n = 20 ) and a control group ( n = 20 ) . Each patient in the trial group received one capsule with each meal containing 500 mg turmeric , of which 22.1 mg was the active ingredient curcumin ( three capsules daily ) for 2 months . The control group received three capsules identical in colour and size containing starch for the same 2 months . Results . Serum levels of TGF-β and IL-8 and urinary protein excretion and IL-8 decreased significantly comparing the pre- and post-turmeric supplementation values . No adverse effects  related to turmeric supplementation were observed during the trial . Conclusion . Short-term turmeric supplementation can attenuate proteinuria , TGF-β and IL-8 in patients with overt type 2 diabetic nephropathy and can be administered as a safe adjuvant therapy for these patients
Conclusion Our findings may encourage curcumin supplementation based on its meaningful effect on glycemic control and positive trend on lipid outcomes in prediabetes and T2DM
Scope Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus ( T2DM ) .
This study aim ed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM .