INTERPRETATION The guidelines have improved method ological reporting in RSA studies , but adherence to these guidelines is still relatively low .
BACKGROUND AND PURPOSE Guidelines for st and ardization of  radiostereometry ( RSA )  of implants were published in 2005 to facilitate comparison of outcomes between various research groups .
In this systematic review , we determined how well studies have adhered to these guidelines .
Celecoxib does not appear to affect prosthesis fixation in total knee replacement
Background and purpose After joint replacement , a repair process starts at the interface between bone and cement . If this process is disturbed , the prosthesis may never become rigidly fixed to the bone , leading to migration— and with time , loosening . Cox-2 inhibitors are widely used as postoperative analgesics , and have adverse effects on bone healing . This could tamper prosthesis fixation . We investigated whether celecoxib , a selective Cox-2 inhibitor , increases prosthesis migration in total knee replacement ( TKR ) . Methods 50 patients were r and omized to either placebo or celecoxib treatment , 200 mg twice daily , for 3 weeks after TKR  ( NexGen ; Zimmer ) . Maximum total point motion ( MTPM ) of the tibial component was measured after 2 years using radiostereometric analysis ( RSA ) . In addition , range of motion , pain , and , subjective outcome were evaluated . Results No differences in prosthesis migration , pain scores , range of motion , and subjective outcome were found after 2 years . Confidence intervals were narrow . Interpretation It is unlikely that Celecoxib increases the risk of loosening , and it may be used safely in conjunction with TKR
INTERPRETATION The guidelines have improved method ological reporting in RSA studies , but adherence to these guidelines is still relatively low .
BACKGROUND AND PURPOSE Guidelines for st and ardization of  radiostereometry ( RSA )  of implants were published in 2005 to facilitate comparison of outcomes between various research groups .
In this systematic review , we determined how well studies have adhered to these guidelines .