Conclusion Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes .
Due to some limitations in this study , further studies are needed to reach a definitive conclusion about the effect of n-3 PUFAs on the levels of leptin and adiponectin in T2DM
Abstract Aim N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines .
Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes , we conducted a systematic review and meta- analysis study of r and omized placebo-controlled clinical trials that examined the effects of n-3 PUFAs on serum levels of leptin and adiponectin in patients with type 2 diabetes .
Effects of seafood consumption and weight loss on fasting leptin and ghrelin concentrations in overweight and obese European young adults
Background Energy restriction affects circulating  leptin and ghrelin concentrations . The aim of this study To investigate whether seafood consumption affects fasting leptin and ghrelin concentrations in addition to weight loss . Methods In this 8-week dietary intervention , subjects ( 324 Icel and ic , Spanish and Irish subjects , 20–40 years , BMI 27.5–32.5 kg/m2 ) were r  and omized to energy-restricted diets ( −30 % ) of identical macronutrient composition but different amount of seafood : control ( no seafood ) ; lean fish ( 150 g cod , three times per week ) ; fatty fish ( 150 g salmon , three times per week ) ; EPA&DHA [ daily docosahexaenoic (DHA)/eicosapentaenoic acid ( EPA ) capsules ] . Anthropometric data , ghrelin , leptin , and insulin were measured at baseline and endpoint . Linear models investigated the effects of seafood on fasting leptin , ghrelin and insulin . Results Body weight ( −5.2 ± 3.0 kg ) , leptin ( −34.8 % ) and insulin ( −13.5 % ) decreased , while ghrelin increased ( 5.6 % ) ( all P < 0.001 ) . According to linear models endpoint insulin was significantly lower in the EPA&DHA group ( −16.4 % , P = 0.025 ) compared to control , endpoint leptin in men was lower in the salmon group ( −22.9 % , P = 0.026 ) , and the EPA&DHA group tended to have higher endpoint ghrelin ( 5.6 % , P = 0.060 ) , an effect seen only in women indicated by a significant gender × EPA&DHA interaction . Weight loss explained the effects of fatty seafood on leptin and ghrelin , but not insulin . Conclusions Consumption of fatty seafood can modulate fasting insulin , ghrelin and leptin during an 8-week intervention . Effects are partly gender specific and are partly explained by weight loss . Consumption of lean fish does not affect circulating hormones in comparison to control . The most consistent effect on circulating hormones is mediated by weight loss
Conclusion Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes .
Due to some limitations in this study , further studies are needed to reach a definitive conclusion about the effect of n-3 PUFAs on the levels of leptin and adiponectin in T2DM
Abstract Aim N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines .
Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes , we conducted a systematic review and meta- analysis study of r and omized placebo-controlled clinical trials that examined the effects of n-3 PUFAs on serum levels of leptin and adiponectin in patients with type 2 diabetes .