All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .
Modulated chemotherapy according to modified comprehensive geriatric assessment in 100 consecutive elderly patients with diffuse large B-cell lymphoma.
Chemotherapy is associated with toxicity in elderly patients with potentially curable malignancies , posing the dilemma of whether to intensify therapy , thereby improving the cure rate , or de-escalate therapy , thereby reducing toxicity , with consequent risks for under- or overtreatment . Adequate tools to define doses and combinations have not been identified for lymphoma patients . We conducted a prospect i ve trial aim ed to evaluate the feasibility and efficacy of chemotherapy modulated according to a modified comprehensive geriatric assessment ( CGA ) in elderly ( aged ≥70 years ) patients with diffuse large B-cell lymphoma ( DLBCL ) . In June 2000 to March 2006 , 100 patients were stratified using a CGA into three groups ( fit , unfit , and frail ) , and they received a rituximab plus cyclophosphamide , doxorubicin , vincristine , and prednisone modulated in dose and drugs according to comorbidities and activities of daily living ( ADL ) and instrumental ADL scores . Treatment was associated with a complete response rate of 81 % and mild toxicity : grade 4 neutropenia in 14 % , anemia in 1 % , and neurological and cardiac toxicity in 2 % of patients . At a median follow-up of 64 months , 51 patients were alive , with 5-year disease-free , overall , and cause-specific survival rates of 80 % , 60 % , and 74 % , respectively . Chemoimmunotherapy adjustments based on a CGA are associated with manageable toxicity and excellent outcomes in elderly patients with DLBCL . Wide use of this CGA-driven treatment may result in better cure rates , especially in fit and unfit patients
All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .