In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients.
Elevated C-reactive protein ( CRP ) , IL-6 and retinol-binding protein 4 ( RBP4 ) levels are associated with insulin resistance and diabetes mellitus . Phytoestrogens ( including lignans and isoflavones ) may enhance the management of diabetes and are hypothesized to act through inflammation pathways . The present study explored the effects of flaxseed-derived lignan on inflammatory factors and RBP4 concentrations in type 2 diabetics , who have higher levels of these biomarkers . Seventy community-dwelling diabetic patients ( twenty-six men and forty-four post-menopausal women ) with mild hypercholesterolaemia completed a r and omized , double-blind , placebo-controlled , cross-over trial of supplementation with flaxseed-derived lignan capsules ( 360 mg/d ) or placebo for 12 weeks , separated by an 8-week wash-out period . The participants maintained their habitual diets and levels of physical activity . Baseline to follow-up concentrations of CRP increased significantly within the placebo group ( 1.42 ( sem 0.19 ) v. 1.96 ( sem 0.22 ) mg/l , P < 0.001 ) , but were comparatively unchanged in the lignan-supplemented group ( 1.67 ( sem 0.19 ) v. 1.90 ( sem 0.26 ) mg/l , P = 0.94 ) ; a significant difference was observed between treatments ( - 0.45 ( 95 % CI - 0.76 , - 0.08 ) mg/l , P = 0.021 ) . This effect was confined to women ( P = 0.016 ) , but not observed in men ( P = 0.49 ) . No between-treatment differences were found with regard to IL-6 or RBP4 ; though IL-6 concentrations increased significantly from baseline to follow-up in both groups ( P = 0.004 and P < 0.001 following lignan and placebo treatments , respectively ) . The study suggests that lignan might modulate CRP levels in type 2 diabetics . These results need to be confirmed by further large clinical trials of longer duration
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .