Using mean data from the validation study , the trend and directionality in risk was similar in the Roux-en-Y group .
In conclusion , bariatric surgery predicts long-term decreases in CV risk in obese patients
Obese patients have an increased prevalence of  cardiovascular ( CV ) risk factors , which improve with bariatric surgery , but whether bariatric surgery reduces long-term CV events remains ill defined .
Cardiovascular risk estimates and risk factors in renal transplant recipients.
Cardiovascular morbidity , including coronary artery disease and left ventricular hypertrophy , and mortality are high in patients following renal transplantation . Cardiovascular disease is thought to be due to traditional ( hypertension , hyperlipidemia , diabetes mellitus and smoking ) as well as nontraditional cardiovascular risk factors ( microinflammation ) . Furthermore , immunosuppressive drugs , namely , calcineurin inhibitors , sirolimus , and steroids , have been reported to adversely affect cardiovascular risk factors ( e.g. , hypertension , hyperlipidemia , hyperglycemia ) . Evidence from comparative trials and from conversion studies suggest that blood pressure , hyperlipidemia , and hyperglycemia after renal transplantation may be differentially affected by the calcineurin inhibitors cyclosporine and tacrolimus . In the European Tacrolimus versus  Cyclosporin A Microemulsion Renal Transplantation Study , 557 patients were r and omly allocated to therapy with tacrolimus  ( n = 286 ) versus cyclosporine ( n = 271 ) . In addition , to blood pressure , serum cholesterol , HDL cholesterol , triglycerides , and blood glucose , we estimated the 10-year risk of coronary heart disease ( Framingham risk score ) . Tacrolimus result ed in a significantly lower time-weighted average of serum cholesterol ( P < .001 ) , and mean arterial blood pressure ( P < .05 ) , but a higher time-weighted average of blood glucose ( P < .01 ) than cyclosporine .  Mean 10-year coronary artery disease risk estimate was significantly lower in men treated with tacrolimus , ( 10.0 % versus 13.2 % ; P < .01 ) but was unchanged in women ( 4.7 % versus 7.0 % ) . Tacrolimus and cyclosporine microemulsion have compound-specific effects on cardiovascular risk factors that differentially affect the predicted rate of coronary artery disease
Using mean data from the validation study , the trend and directionality in risk was similar in the Roux-en-Y group .
In conclusion , bariatric surgery predicts long-term decreases in CV risk in obese patients
Obese patients have an increased prevalence of  cardiovascular ( CV ) risk factors , which improve with bariatric surgery , but whether bariatric surgery reduces long-term CV events remains ill defined .