R and omized controlled trials found a positive correlation for SB with BMI , neck circumference , fat mass , HbA1C , cholesterol and insulin levels , cohort studies additionally for WC , leptin , C-peptide , ApoA1 and Low density lipoprotein and a negative correlation for HDL .
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin .
OBJECTIVE Pathomechanisms of sedentary behaviour ( SB ) are unclear .
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults .
A randomized trial investigating the 12-month changes in physical activity and health outcomes following a physical activity consultation delivered by a person or in written form in Type 2 diabetes: Time2Act.
BACKGROUND AND AIMS Physical activity is a cornerstone of Type 2 diabetes management but is underutilized . Physical activity consultations increase physical activity in people with Type 2 diabetes but re sources are often limited . Time2Act is a r and omized control trial to study the 12-month effectiveness of a physical activity consultation delivered by a person or in written form , in contrast to st and ard care , for people with Type 2 diabetes . METHODS A total of 134 inactive people with Type 2 diabetes in a contemplation or preparation stage were r and omized to either intervention or st and ard care .  Objective ( accelerometer ) and subjective ( 7-day recall ) physical activity levels were measured over 1 week , along with physiological [ blood pressure , body mass index ( BMI ) , waist circumference ] and biochemical [ glycated haemoglobin ( HbA(1c ) ) , total and high-density lipoprotein ( HDL ) cholesterol ] measures at baseline , 6 and 12 months . RESULTS Neither a physical activity consultation delivered by a person nor in written form was better than st and ard care at increasing physical activity levels or improving health outcomes in the full study cohort . Total and HDL cholesterol , waist circumference and both systolic and diastolic blood pressure improved over 12 months in all groups , whilst HbA(1c ) improved over 6 months . In a subgroup ( baseline pedometer steps < 5000/day ) , the physical activity consultation delivered by a person significantly increased physical activity over 12 months and the st and ard care group significantly decreased . CONCLUSIONS More research is needed which not only investigates the most economical and effective methods to promote physical activity , but also the best setting to conduct physical activity consultations and the participant factors affecting uptake of physical activity in Type 2 diabetes
R and omized controlled trials found a positive correlation for SB with BMI , neck circumference , fat mass , HbA1C , cholesterol and insulin levels , cohort studies additionally for WC , leptin , C-peptide , ApoA1 and Low density lipoprotein and a negative correlation for HDL .
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin .
OBJECTIVE Pathomechanisms of sedentary behaviour ( SB ) are unclear .
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults .