Meta- analysis revealed few clinical ly relevant and statistically significant benefits of " add-on " therapies on exercise performance compared with exercise training .
The aim of this review was to identify the effectiveness of therapies added on to conventional exercise training to maximise exercise capacity in patients with chronic obstructive pulmonary disease ( COPD ) .
Combined effect of dietary supplementation with pressurized whey and exercise training in chronic obstructive pulmonary disease: a randomized, controlled, double-blind pilot study.
Pressurized whey supplementation , by its antioxidant and nutritional properties , may improve exercise tolerance and potentiate the effects of exercise training in patients with chronic obstructive pulmonary disease ( COPD ) . In this r and omized , double-blind , placebo-controlled study , 22 patients with COPD were allocated to receive active pressurized whey or placebo ( casein ) dietary supplementation for a 16-week period . Patients continued their usual physical activities for the first 8 weeks , whereas they were subjected to an exercise training program for the remaining 8 weeks of the study . Patients were evaluated at baseline , after 8 weeks of supplementation alone ( time point , 8 weeks ) , and after 8 weeks of its combination with exercise training ( time point , 16 weeks ) . The constant workrate cycle endurance test ( CET ) , potentiated quadriceps twitch force , mid-thigh cross-sectional area , and Chronic Respiratory Question naire ( CRQ ) were used to evaluate the effects of treatments . The inflammatory ( C-reactive protein and interleukin-6 ) and oxidant/antioxidant ( protein oxidation and glutathione ) blood profiles were also characterized . At week 8 , there was no increase in CET time in either group . At week 16 , there was a statistically significant increase in CET time in the whey-only group ( P < .05 ) . Further , at week 16 , there was clinical ly significant improvement in the Dyspnea and the Mastery scales of the CRQ in both groups . Also , the Fatigue and Emotional Control scales of the CRQ showed clinical ly significant improvement in the whey-only group . Study interventions did not modify significantly the systemic inflammatory and oxidative stress markers that were assessed . Thus dietary supplementation with pressurized whey may potentiate the effects of exercise training on exercise tolerance and quality of life in patients with COPD
Meta- analysis revealed few clinical ly relevant and statistically significant benefits of " add-on " therapies on exercise performance compared with exercise training .
The aim of this review was to identify the effectiveness of therapies added on to conventional exercise training to maximise exercise capacity in patients with chronic obstructive pulmonary disease ( COPD ) .