We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .
Treatment of benign essential hypertension with frusemide in different doses.
A double-blind , r and omized , crossover trial was carried out in 26 hypertensive patients to investigate the hypotensive effects of three different dosages of frusemide ( 40 mg , 60 mg , and 80 mg twice daily ) and the effects on serum potassium and urinary output . The study included a 4-week treatment period with placebo , three periods of 6 weeks with frusemide , and an intervening placebo period of 4 weeks . The mean arterial blood pressure fell about 10 mmHg within the first 2 weeks and was independent of the frusemide dosage . During the following weeks of treatment , there was a constant , slow fall in blood pressure . The period on placebo was too brief for values to return to the initial level . In contrast , the increase in urinary output , which was dose-dependent , ceased when medication was withdrawn . The diuretic effect was maintained throughout the treatment periods . There was a correlation between the fall in serum potassium and the diuretic effect whereas no correlation with the fall in blood pressure could be shown . Except for a significant increase in serum zinc , no changes were observed in other electrolyte parameters . Body weight , pulse , haemoglobin and erythrocyte sedimentation rate remained unchanged . Side-effects were few and mild , but tended to increase with higher doses
We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .