Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .
A double-blind trial of low- and high-dose ranges of gepirone-ER compared with placebo in the treatment of depressed outpatients.
We report the results of a double-blind study comparing the efficacy and safety of low-dose ( 10 - 50 mg ) and high-dose ( 20 - 100 mg ) ranges of gepirone-extended release ( ER ) and placebo in 145 out patients with major depressive disorder . At multiple time points and endpoint ( Week 6 ) , statistically significant reductions in Hamilton Rating Scale for Depression ( HAM-D ) scores were recorded for high-dose gepirone-ER compared to placebo . Analysis of the 17-item HAM-D and 28-item HAM-D scores indicated a relatively early onset of antidepressant efficacy with statistically significant results at treatment Weeks 1 , 2 , 4 , and 6 . A rapid response was evident in the high-dose group , beginning at Week 1 ( p < .05 ) . The most frequently reported adverse experiences were headache , nausea , dizziness , and insomnia . The results indicate that gepirone-ER is clearly superior to placebo in terms of antidepressant efficacy . When used at higher doses , gepirone-ER appears to be efficacious , safe , and well-tolerated in depressed out- patients
Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .