In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .
Short-term consumption of sucralose, a nonnutritive sweetener, is similar to water with regard to select markers of hunger signaling and short-term glucose homeostasis in women.
Nonnutritive sweeteners have been used to lower the energy density of foods with the intention of affecting weight loss or weight maintenance . However , some epidemiological and animal evidence indicates an association between weight gain or insulin resistance and artificial sweetener consumption . In the present study , we hypothesized that the nonnutritive sweetener sucralose , a trichlorinated sucrose molecule , would elicit responses similar to water but different from sucrose and sucrose combined with sucralose on subjective and hormonal indications of hunger and short-term glucose homeostasis . Eight female volunteers ( body mass index , 22.16 ± 1.71 kg/m(2 ) ; age , 21.75 ± 2.25 years )  consumed sucrose and /or sucralose in water in a factorial design . Blood sample s were taken at fasting and 30 and 60 minutes after treatment followed by a st and ardized breakfast across treatments , and blood sample s were taken 30 , 60 , 90 , and 120 minutes after breakfast . Plasma was analyzed for glucose , insulin , glucagon , triacylglycerols ( TAG ) , and acylated ghrelin . Perceptions of hunger and other subjective measurements were assessed before each blood sample . No differences were detected in subjective responses , circulating triacylglycerol , or glucagon concentrations among treatments over time . Significant differences were observed in insulin , glucose , and acylated ghrelin concentrations over time only between sucrose-containing treatments and non-sucrose-containing treatments regardless of sucralose consumption . Therefore , sucralose may be a relatively inert nonnutritive sweetener with regard to hunger signaling and short-term glucose homeostasis
In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .