In both rodent and cell culture models , CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus .
In rodent models , CBD was found to attenuate alcohol-induced hepatotoxicity , specifically , alcohol-induced steatosis .
Finally , findings from pre clinical rodent models also indicate that CBD attenuates cue-elicited and stress-elicited alcohol seeking , alcohol self-administration , withdrawal-induced convulsions , and impulsive discounting of delayed rewards .
In human studies , CBD was well tolerated and did not interact with the subjective effects of alcohol .
Collectively , given its favorable effects on alcohol-related harms and addiction phenotypes in pre clinical models , CBD appears to have promise as a c and i date AUD pharmacotherapy .
This is further bolstered by the absence of abuse liability and its general tolerability .
There is substantial interest in the therapeutic potential of cannabidiol ( CBD ) , a nonpsychoactive cannabinoid found in plants of the genus Cannabis .
The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a c and i date pharmacotherapy for alcohol use disorder ( AUD ) .
Interaction of cannabidiol and alcohol in humans
Six male and four female healthy volunteers were given oral placebo ( glucose capsule and orange juice ) , cannabidiol ( CBD 200 mg capsule and orange juice ) , alcohol ( 1 g/kg in orange juice and glucose capsule ) , and CBD ( 200 mg capsule ) plus alcohol ( 1 g/kg in orange juice ) in a double-blind , crossover , r and omized design . Treatments were spaced one week apart . Parameters measured were a finger tap test ( motor performance ) , cancellation and differential aptitude tests ( psychomotor performance ) , a 1-min time production task , subjective effects ( 66 item adjective-pair semantic differential ) , and breathalyzer estimations of blood alcohol levels . Compared to placebo , alcohol and alcohol plus CBD , but not CBD alone , produced significant impairments of motor and psychomotor performances , overestimations of time production and subjective responses indicating an accurate self-perception of their intoxication and deficits . The combination of alcohol plus CBD result ed in significantly lower blood alcohol levels compared to alcohol given alone , however , there were few differences observed between the pharmacological effects of the two alcohol conditions . Thus , the inactivity of CBD , a major marijuana constituent , on motor and mental performance and effects also extends to its interaction with alcohol
In both rodent and cell culture models , CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus .
In rodent models , CBD was found to attenuate alcohol-induced hepatotoxicity , specifically , alcohol-induced steatosis .
Finally , findings from pre clinical rodent models also indicate that CBD attenuates cue-elicited and stress-elicited alcohol seeking , alcohol self-administration , withdrawal-induced convulsions , and impulsive discounting of delayed rewards .
In human studies , CBD was well tolerated and did not interact with the subjective effects of alcohol .
Collectively , given its favorable effects on alcohol-related harms and addiction phenotypes in pre clinical models , CBD appears to have promise as a c and i date AUD pharmacotherapy .
This is further bolstered by the absence of abuse liability and its general tolerability .
There is substantial interest in the therapeutic potential of cannabidiol ( CBD ) , a nonpsychoactive cannabinoid found in plants of the genus Cannabis .
The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a c and i date pharmacotherapy for alcohol use disorder ( AUD ) .