Effects of antihypertensive drugs on SBP variability are dose-dependent and persist when used in combinations .
Use of a high dose of a calcium channel blocker alone or in combination with other agents is therefore likely to be particularly effective in prevention of stroke
BACKGROUND AND PURPOSE Recent studies have shown that visit-to-visit blood pressure variability is a powerful risk factor for stroke , is reduced by calcium channel blockers and diuretics , and increased by β-blockers .
However , it is unknown whether these effects are dose-dependent and persist in combination with other drugs .
Prophylactic Treatment of Migraine with Bisoprolol
The objective of the present study was to assess the efficacy of bisoprolol in  migraine prophylaxis .  A double-blind placebo-controlled study was conducted in 226 patients with migraine with or without aura , a migraine history of at least 2 years and at least 3 documented attacks during the 28 days run-in period . The duration of treatment was 12 weeks following an initial 28 days ' run-in period . Patients reported the number of attacks and their severity in a diary . Treatment with bisoprolol 5 mg result ed in a significant reduction in the frequency of migraine attacks ( 39 % vs 22 % ) compared to placebo treatment ( p<0.05 ) . Treatment had no effect on the duration and severity of the attacks .  Bisoprolol was well tolerated
Effects of antihypertensive drugs on SBP variability are dose-dependent and persist when used in combinations .
Use of a high dose of a calcium channel blocker alone or in combination with other agents is therefore likely to be particularly effective in prevention of stroke
BACKGROUND AND PURPOSE Recent studies have shown that visit-to-visit blood pressure variability is a powerful risk factor for stroke , is reduced by calcium channel blockers and diuretics , and increased by β-blockers .
However , it is unknown whether these effects are dose-dependent and persist in combination with other drugs .