The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Monotherapy of essential hypertension with a converting-enzyme inhibitor.
The antihypertensive effectiveness of twice-daily dosing with the converting enzyme inhibitor , captopril , was examined in a multicenter study of 294 patients ( 181 white , 111 black , two oriental ) with essential hypertension whose supine diastolic blood pressure ( SDBP ) was 95 mm Hg or higher after 4 to 6 weeks of preliminary placebo administration . In this double-blind study , the patients were r and omized into one placebo and three captopril-treated groups : twice-daily placebo ( n = 77 ) or twice-daily captopril 25 mg ( n = 77 ) , 50 mg ( n = 71 ) , or 100 mg ( n = 69 ) . The average decreases in SDBP after 8 weeks of treatment were 5.2 % , 7.7 % , 11.7 % , and 10.5 % , respectively . Only the two higher dose groups differed significantly from the placebo group ; they also differed from the lowest dose group . The proportions of patients classified as having normalized pressures ( SDBP less than 90 mm Hg ) in the four groups were 39 % , 47 % , 70 % , and 50 % . If the results were analyzed by race , all three captopril-treated groups differed significantly from the placebo-treated group in the white patients but not in the black patients . However , direct comparisons between the white and black groups showed a difference only at the low , 25 mg twice daily ( b.i.d . ) , captopril dose . Thus , although conventionally given on a three-times daily basis , the twice-daily ( 12-hourly ) administration of captopril provides effective antihypertensive treatment in doses of 50 or 100 mg b.i.d . Moreover , white patients also exhibit a significant response to captopril at doses as low as 25 mg b.i.d . ( ABSTRACT TRUNCATED AT 250 WORDS
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .