Resveratrol  significantly improves adiponectin but does not affect leptin concentrations .
Abstract The results of human clinical trials have revealed that the effects of resveratrol on adipokines are inconsistent .
Influence of quercetin-rich onion peel extracts on adipokine expression in the visceral adipose tissue of rats.
We examined the effects of quercetin-rich onion peel extract supplementation on adipokine expressions from adipose tissues in a diet-induced obese animal model . Male Sprague-Dawley rats ( n = 24 ) were r and omly assigned into control ( n = 8) , high fat diet ( HF , n = 8) and high fat diet with onion peel extract ( HFOE , n = 8) . After 8 weeks , serum biochemical parameters , weights of adipose tissues ( epididymal , perirenal and mesenteric fats ) and adipokine mRNA levels ( adiponectin , IL (interleukin)-6 and visfatin ) along with PPAR ( peroxisome proliferator-activated receptor ) γ2 from adipose tissues were measured . After the 8 week supplementation , mesenteric fat weights were lower in the HFOE group than the HF group ( p < 0.05 ) . Adiponectin mRNA levels ( mesenteric fats ) were remarkably higher in the HFOE group than the other groups ( p < 0.05 for both ) . Levels of PPARγ2 mRNA ( mesenteric fats ) were significantly higher in the HF group ( p < 0.05 ) than those in the control group , but those in the HFOE group were not different from those in the control group . The IL-6 mRNA levels ( perirenal and mesenteric fats ) were higher in the HF and HFOE groups , but those in the HFOE group were slightly lower than those in the HF group . In conclusion , quercetin-rich onion peel extract supplementation  influenced adipokine expressions , particularly from mesenteric fat , addressing the modulatory effect of this substance on obesity-induced inflammation
Resveratrol  significantly improves adiponectin but does not affect leptin concentrations .
Abstract The results of human clinical trials have revealed that the effects of resveratrol on adipokines are inconsistent .