This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .
Application of sublingual buprenorphine in combination with naproxen or paracetamol for post‐operative pain relief in cholecystectomy patients in a double‐blind study
In a double‐blind , placebo‐controlled study in 125 patients undergoing a cholecystectomy , a comparison was made of the quality of post‐operative pain relief during ‘ patient‐controlled ’ intake of sublingual buprenorphine in combination with either rectally administered naproxen 1000 mg/24 h , paracetamol 4000 mg/24 h or a placebo . Results obtained in 97 patients were analysed . Five of these patients needed a rescue medication with morphine hydrochloride intramuscularly because of insufficient pain relief or because of nausea and vomiting . The quality of pain relief , as measured on a four‐point scale , was comparable in all three groups throughout the study period and no significant differences became apparent . Only on the day of surgery ( day 0 ) was intake of buprenorphine  significantly greater in the placebo group ( 2.3 tablets/24 h ) than in the naproxen and paracetamol groups ( 1.8 and 1.5 tablets/24 h , respectively ) . It is concluded that after cholecystectomy ‘ patient‐controlled ’ intake of sublingual buprenorphine as a sole agent provides acceptable pain relief in about 80 % of patients . More elaborate methods , such as intravenous patient‐controlled analgesia , might be necessary to achieve good pain relief in the remainder of these patients
This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .