Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .
Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women.
OBJECTIVE To investigate the effect of soy protein supplementation with known levels of phytoestrogens on cardiovascular disease risk factors and menopausal symptoms in perimenopausal women . METHODS A r and omized , double-blind crossover trial was conducted in 51 women consuming isocaloric supplements containing 20 g of complex carbohydrates ( comparison diet ) , 20 g of soy protein containing 34 mg of phytoestrogens given in a single dose , and 20 g of soy protein containing 34 mg of phytoestrogens split into two doses .  Women were r and omly assigned to one of the three diets for 6-week periods and subsequently were r and omized to the remaining two interventions to determine whether differences existed between the treatment diets for cardiovascular disease risk factors , menopausal symptoms , adherence , and potential adverse effects . RESULTS Significant declines in total cholesterol ( 6 % lower ) and low density lipoprotein cholesterol ( 7 % lower ) were observed in both soy diets compared with the carbohydrate placebo diet . A significant decline in diastolic blood pressure ( 5 mm Hg lower ) was noted in the twice-daily soy diet , compared with the placebo diet . Although nonsignificant effects were noted for a number of measures of quality of life , a significant improvement was observed for the severity of vasomotor symptoms and for hypoestrogenic symptoms in the twice-daily group compared with the placebo group . No significant effects were noted for triglycerides , high density lipoprotein cholesterol or frequency of menopausal symptoms . Adherence was excellent in all groups . CONCLUSIONS Soy supplementation in the diet of nonhypercholesterolemic , nonhypertensive , perimenopausal women result ed in significant improvements in lipid and lipoprotein levels , blood pressure , and perceived severity of vasomotor symptoms . These data corroborate the potential importance of soy supplementation in reducing chronic disease risk in Western population
Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .