Some studies suggest that testosterone therapy has additional effects , which include increased bone mineral density and decreased serum high-density lipoprotein ( HDL ) cholesterol .
The clinical sequelae of oestrogen deficiency during menopause are undoubted .
However , the pathophysiological role of testosterone during the menopause is less clear .
Several r and omized , placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women .
Effects of testosterone administration on cognitive function in hysterectomized women with low testosterone levels: a dose–response randomized trial
Purpose To determine the dose-dependent effects of testosterone administration on cognition in women with low testosterone levels . Methods 71 hysterectomized women with or without oophorectomy with total testosterone < 31 ng/dl and /or free testosterone < 3.5 pg/ml received a st and ardized transdermal estradiol regimen during the 12-week run-in period and were then r and omized to receive weekly intramuscular injections of placebo , 3 , 6.25 , 12.5 , or 25 mg testosterone enanthate for 24 weeks .  Total testosterone  was measured in serum by LC – MS/MS , and free testosterone levels were measured by equilibrium dialysis .  Cognitive function was evaluated using a comprehensive battery of st and ardized neuropsychological tests at baseline and 24 weeks . Results 46 women who had baseline and end-of-treatment cognitive function data constituted the analytic sample . The five groups were similar at baseline . Mean on-treatment nadir total testosterone concentrations were 15 , 89 , 98 , 134 , and 234 ng/dl in the placebo , 3 , 6.25 , 12.5 , and 25 mg groups , respectively . No significant changes in spatial ability , verbal fluency , verbal memory , or executive function were observed in any treatment arm compared to placebo even after adjustment for baseline cognitive function , age , and education . Multiple regression analysis did not show any significant relation between changes in testosterone concentrations and change in cognitive function scores . ConclusionS hort-term testosterone administration over a wide range of doses for 24 weeks in women with low testosterone levels was neither associated with improvements nor worsening of cognitive function
Some studies suggest that testosterone therapy has additional effects , which include increased bone mineral density and decreased serum high-density lipoprotein ( HDL ) cholesterol .
The clinical sequelae of oestrogen deficiency during menopause are undoubted .
However , the pathophysiological role of testosterone during the menopause is less clear .
Several r and omized , placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women .