They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .
Vitamin D3 Supplementation and Childhood Diarrhea: A Randomized Controlled Trial
OBJECTIVE : To investigate the effect of vitamin D3 supplementation on the incidence and risk for first and recurrent diarrheal illnesses among children in Kabul , Afghanistan . METHODS : This double-blind placebo-controlled trial r and omized 3046 high-risk 1- to 11-month-old infants to receive 6 quarterly doses of oral vitamin D3 ( cholecalciferol 100 000 IU ) or placebo in inner city Kabul . Data on diarrheal episodes ( ≥3 loose/liquid stools in 24 hours ) was gathered through active and passive surveillance over 18 months of follow-up . Time to first diarrheal illness was analyzed by using Kaplan-Meier plots . Incidence rates and hazard ratios ( HRs ) were calculated by using recurrent event Poisson regression models . RESULTS : No significant difference existed in survival time to first diarrheal illness ( log rank P = .55 ) . The incidences of diarrheal episodes were 3.43 ( 95 % confidence interval [ CI ] , 3.28–3.59 ) and 3.59 per child-year ( 95 % CI , 3.44–3.76 ) in the placebo and intervention arms , respectively . Vitamin D3 supplementation was found to have no effect on the risk for recurrent diarrheal disease in either intention-to-treat ( HR , 1.05 ; 95 % CI , 0.98–1.17 ; P = .15 ) or per protocol ( HR , 1.05 ; 95 % CI , 0.98–1.12 ; P = .14 ) analyses . The lack of preventive benefit remained when the r and omized population was stratified by age groups , nutritional status , and seasons . CONCLUSIONS : Quarterly supplementation with vitamin D3 conferred no reduction on time to first illness or on the risk for recurrent diarrheal disease in this study . Similar supplementation to comparable population s is not recommended . Additional research in alternative setting s may be helpful in elucidating the role of vitamin D3 supplementation for prevention of diarrheal diseases
They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .