The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .
Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress.
In vitro studies have shown that alpha-lipoic acid ( LA ) is an antioxidant . There is a paucity of studies on LA supplementation in humans . Therefore , the aim of this study was to assess the effect of oral supplementation with LA alone and in combination with alpha-tocopherol ( AT ) on measures of oxidative stress . A total of 31 healthy adults were supplemented for 2 months either with LA ( 600 mg/d , n = 16 ) , or with AT ( 400 IU/d , n = 15 ) alone , and then with the combination of both for 2 additional months . At baseline , after 2 and 4 months of supplementation , urine for F2-isoprostanes , plasma for protein carbonyl measurement and low-density lipoprotein ( LDL ) oxidative susceptibility was collected . Plasma oxidizability was assessed after incubation with 100 mM 2,2'-azobis ( 2-amidinopropane ) hydrochloride ( AAPH ) for 4 h at 37 degrees C. LDL was subjected to copper- and AAPH-catalyzed oxidation at 37 degrees C over 5 h and the lag time was computed . LA significantly increased the lag time of LDL lipid peroxide formation for both copper-catalyzed and AAPH-induced LDL oxidalion ( p < .05 ) , decreased urinary F2-isoprostanes levels ( p < .05 ) , and plasma carbonyl levels after AAPH oxidation ( p < .001 ) . AT prolonged LDL lag time of lipid peroxide formation ( p < .01 ) and conjugated dienes ( p < .01 ) after copper-catalyzed LDL oxidation , decreased urinary F2-isoprostanes ( p < .001 ) , but had no effect on plasma carbonyls . The addition of LA to AT did not produce an additional significant improvement in the measures of oxidative stress . In conclusion , LA supplementation functions as an antioxidant , because it decreases plasma- and LDL-oxidation and urinary isoprostanes
The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .