Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .
Vitamin D and inflammatory markers: cross-sectional analyses using data from the English Longitudinal Study of Ageing (ELSA)
Recent evidence suggests that low vitamin D concentrations are associated with increased levels of inflammatory markers . However , there are limited studies investigating associations between vitamin D levels and inflammatory markers in the general population and much of this evidence in older adults is inconclusive . Therefore , this study investigates the cross-sectional association of  serum 25-hydroxyvitamin D ( 25(OH)D ) levels with inflammatory markers in 5870 older English adults from wave 6 ( 2012–2013 ) of the English Longitudinal Study of Ageing ( ELSA ) . ELSA is a large prospect i ve observational study of community-dwelling people aged 50 years and over in Engl and . Serum 25(OH)D levels , C-reactive protein ( CRP ) levels , plasma fibrinogen levels , white blood cell count ( WBC ) , age , season of blood collection , waist circumference , total non-pension household wealth , measures of health and health behaviours that included depression , number of cardiovascular , non-cardiovascular conditions and difficulties in activities of daily living , smoking , and physical activity were measured . There was a significant negative association between low 25(OH)D levels ( ≤30 nmol/l ) and CRP ( OR 1·23 , 95 % CI 1·00 , 1·51 ) and WBC ( OR 1·35 , 95 % CI 1·13 , 1·60 ) that remained after adjustment for a wide range of covariates of clinical significance . However , for fibrinogen , the association did not remain significant when waist circumference was entered in the final model . Our findings showed that 25(OH)D levels were associated with two out the three inflammatory markers investigated . The independent and inverse association between serum 25(OH)D levels and inflammation suggests a potential anti-inflammatory role for vitamin D in older English individuals from the general population
Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .