Both synthetic and naturally derived crosslinkers have been found to exhibit significant effects in biomodification of dentine via their multiple interactions with the dentine matrix .
A stable matrix network or a durable hybrid layer in dentine bonding could be achieved , where the dentine collagen fibrils show improved biochemical and biomechanical properties and enzymatic biodegradation is reduced .
This aim of this review is to explore the current research related to  crosslinking agents used on dentine .
UVA-activated riboflavin improves the strength of human dentin.
The aim of this study was to evaluate the effects of UVA-activated riboflavin ( UVA-RF ) on the mechanical properties of non-demineralized human dentin . Dentin specimens obtained from 20 teeth were r and omly divided into the following four groups : group 1 ( control ) : no treatment , group 2 ( low UVA-RF ) : specimens were exposed to UVA-RF for 10 min , group 3 ( medium UVA-RF ) : specimens were exposed to UVA-RF for 30 min , and group 4 ( high UVA-RF ) : specimens were exposed to UVA-RF for 60 min . Three-point flexural test and Raman spectroscopic analyses were performed . The mean flexural strengths ( MPa ) were 129.96 , 128.96 , 144.21 , and 147.54 , and the mean elastic modulus ( GPa ) were 8.59 , 8.38 , 10.21 , and 9.87 for groups 1 to 4 , respectively . Raman spectra showed chemical modifications of dental collagen under medium and high UVA-RF treatment . We conclude that medium and high UVA-RF increases the strength of non-demineralized human dentin  by collagen crosslinking
Both synthetic and naturally derived crosslinkers have been found to exhibit significant effects in biomodification of dentine via their multiple interactions with the dentine matrix .
A stable matrix network or a durable hybrid layer in dentine bonding could be achieved , where the dentine collagen fibrils show improved biochemical and biomechanical properties and enzymatic biodegradation is reduced .
This aim of this review is to explore the current research related to  crosslinking agents used on dentine .