Conclusions The last 10 years has seen a substantial increase in the number of mapping studies and some evidence of advancement in methods with consideration of models beyond OLS and greater reporting of predictive ability of mapping functions
Background Mapping is an increasingly common method used to predict instrument-specific preference-based health-state utility values ( HSUVs ) from data obtained from another health-related quality of life ( HRQoL ) measure .
There have been several method ological developments in this area since a previous review up to 2007 .
Exploring the impact of changes in neurogenic urinary incontinence frequency and condition-specific quality of life on preference-based outcomes
Purpose Many trials do not measure quality -adjusted life years ( QALYs ) . Therefore , decision analysts often map condition-specific outcomes to preference scores . We estimated the relationship between changes in preference scores and commonly reported condition-specific outcomes in patients with urinary incontinence ( UI ) due to neurogenic detrusor overactivity . Methods In 59 patients recruited to a neurogenic UI trial , clinical outcomes ( UI episodes ) , condition-specific quality of life ( Incontinence Quality of Life Instrument ( I-QOL ) ) , and SF-6D preference scores were measured at enrollment and 24 weeks . We used multiple linear regression to estimate the impact on SF-6D scores of 50 ; 50–99 and 100 % reductions in UI episodes and a 10-point improvement in I-QOL . Results By 24 weeks , mean ( 95 % CI ) daily UI episodes fell by 0.85 ( 0.04 , 1.3 ) and mean I-QOL scores improved by 18 ( 12 , 24 ) . SF-6D scores increased by 0.03 ( 0.003 , 0.058 ) , due to improvements in role limitations . A ≥ 50 % reduction in UI episodes was achieved by 49 % of patients and corresponded to a 0.09 ( 0.02 , 0.16 ) SF-6D increase . A ≥ 10-point increase in I-QOL was attained by 65 % of patients and was associated with a 0.05 ( −0.02 , 0.12 ) SF-6D increase . Conclusions These estimates provide preliminary data for decision analysts wishing to map neurogenic UI outcomes to preference scores
Conclusions The last 10 years has seen a substantial increase in the number of mapping studies and some evidence of advancement in methods with consideration of models beyond OLS and greater reporting of predictive ability of mapping functions
Background Mapping is an increasingly common method used to predict instrument-specific preference-based health-state utility values ( HSUVs ) from data obtained from another health-related quality of life ( HRQoL ) measure .
There have been several method ological developments in this area since a previous review up to 2007 .