Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Effects of High-Protein Versus High-Carbohydrate Diets on Markers of β-Cell Function, Oxidative Stress, Lipid Peroxidation, Proinflammatory Cytokines, and Adipokines in Obese, Premenopausal Women Without Diabetes
OBJECTIVE To study the effects of high-protein versus high-carbohydrate diets on various metabolic end points ( glucoregulation , oxidative stress [ dichlorofluorescein ] , lipid peroxidation [ malondialdehyde ] , proinflammatory cytokines [ tumor necrosis factor-α and interleukin-6 ] , adipokines , and resting energy expenditure [ REE ] ) with high protein – low carbohydrate ( HP ) and high carbohydrate – low protein ( HC ) diets at baseline and after 6 months of dietary intervention . RESEARCH DESIGN AND METHODS We recruited obese , premenopausal women aged 20–50 years with no diabetes or prediabetes who were r and omized to HC ( 55 % carbohydrates , 30 % fat , and 15 % protein ) or HP ( 40 % carbohydrates , 30 % fat , and 30 % protein ) diets for 6 months . The diets were provided in prepackaged food , which provided 500 kcal restrictions per day . The above metabolic end points were measured with HP and HC diet at baseline and after 6 months of dietary intervention . RESULTS After 6 months of the HP versus HC diet ( 12 in each group ) , the following changes were significantly different by Wilcoxon rank sum test for the following parameters : dichlorofluorescein ( −0.8 vs. −0.3 µmol/L , P < 0.0001 ) , malondialdehyde ( −0.4 vs. −0.2 μmol/L , P = 0.0004 ) , C-reactive protein ( −2.1 vs. −0.8 mg/L , P = 0.0003 ) , E-selectin ( −8.6 vs. −3.7 ng/mL , P = 0.0007 ) , adiponectin ( 1,284 vs. 504 ng/mL , P = 0.0011 ) , tumor necrosis factor-α ( −1.8 vs. −0.9 pg/mL , P < 0.0001 ) , IL-6 ( −1.3 vs. −0.4 pg/mL , P < 0.0001 ) , free fatty acid ( −0.12 vs. 0.16 mmol/L , P = 0.0002 ) , REE ( 259 vs. 26 kcal , P < 0.0001 ) , insulin sensitivity ( 4 vs. 0.9 , P < 0.0001 ) , and β-cell function ( 7.4 vs. 2.1 , P < 0.0001 ) . CONCLUSIONS To our knowledge , this is the first report on the significant advantages of a 6-month hypocaloric HP diet versus hypocaloric HC diet on markers of β-cell function , oxidative stress , lipid peroxidation , proinflammatory cytokines , and adipokines in normal , obese females without diabetes
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .