Strict control [ systolic BP ( SBP ) < 140 mmHg ] was not consistently better than mild control ( SBP < 150 mmHg ) for adults aged ≥65 years .
Mild SBP control benefitted subjects in all age ranges over 65 years .
Conclusions In this review , older adults with hypertension had decreased cardiovascular morbidity and mortality  with antihypertensives compared with no treatment .
Strict control was not consistently better than mild control in older adults .
The current evidence is insufficient to determine the safest , most beneficial hypertension regimen in older adults
Background Hypertension increases with increasing age .
Optimal treatment of hypertension is important to reduce cardiovascular disease .
Recent guidelines for hypertension have made recommendations for older adults but are supported by evidence that includes younger individuals .
This systematic review evaluates the benefits and harms of antihypertensive agents in adults aged ≥65 years .
Relation between drug treatment and cancer In hypertenslves in the Swedish Trial in Old Patients with Hypertension 2: a 5-year, prospective, randomised, controlled trial
BACKGROUND Is cancer related to hypertension and blood pressure ? Do antihypertensive drugs promote cancer ? Do antihypertensive drugs protect against cancer ? We previously analysed the frequency of  cardiovascular mortality and morbidity in elderly people who participated in the Swedish Trial in Old Patients with Hypertension 2 ( STOP-Hypertension-2 ) . We have also looked at the frequency of cancer in these patients . METHODS We r and omly assigned 6614 elderly patients with hypertension ( mean age 76 years , median time of follow-up 5.3 years ) to one of three treatment strategies : conventional drugs ( diuretics or b-blockers ) , calcium antagonists , or ACE inhibitors . We matched the patients to the Swedish Cancer Registry and compared our findings with expected values based on age , sex , and calendar-year-specific reference frequencies for the general Swedish population . We also compared the number of cancers between the three treatment groups . FINDINGS At baseline , 607 ( 9 % ) patients had previous malignant disease . Diagnoses were closely similar to the distribution of cancer types that might be seen in elderly patients . During follow-up , there were 625 new cases of cancer in 590 patients . The frequency of cancer did not differ significantly between the treatment strategies , including all cancers and those at individual sites . The st and ardised incidence ratios ( SIRs ) for all cancers were also close to unity : 0.92 ( 95 % CI 0.80 - 1.06 ) for conventional drugs , 0.96 ( 0.83 - 1.10 ) for calcium antagonists , and 0.99 ( 0.86 - 1.13 ) for ACE inhibitors . INTERPRETATIONS No difference in cancer risk was seen between patients r and omly assigned to conventional drugs , calcium antagonists , or ACE inhibitors . Thus , the general message to the practising physician is that more attention should be given to getting the blood pressure down than to the risk of cancer
Strict control [ systolic BP ( SBP ) < 140 mmHg ] was not consistently better than mild control ( SBP < 150 mmHg ) for adults aged ≥65 years .
Mild SBP control benefitted subjects in all age ranges over 65 years .
Conclusions In this review , older adults with hypertension had decreased cardiovascular morbidity and mortality  with antihypertensives compared with no treatment .
Strict control was not consistently better than mild control in older adults .
The current evidence is insufficient to determine the safest , most beneficial hypertension regimen in older adults
Background Hypertension increases with increasing age .
Optimal treatment of hypertension is important to reduce cardiovascular disease .
Recent guidelines for hypertension have made recommendations for older adults but are supported by evidence that includes younger individuals .
This systematic review evaluates the benefits and harms of antihypertensive agents in adults aged ≥65 years .