In this network meta- analysis , we demonstrated that SeR did not show clinical ly meaningful improvement in LUTS and PF .
PATIENT SUMMARY In the present study , we found no clinical ly meaningful improvement of Serenoa repens for the treatment of lower urinary tract symptoms/benign prostatic enlargement .
CONTEXT International guidelines do not make any specific recommendations on Serenoa repens ( SeR ) for the treatment of male lower urinary tract symptoms ( LUTS ) secondary to benign prostatic enlargement ( BPE ) , due to product heterogeneity and method ological limitations of the published trials and meta-analyses .
OBJECTIVE We aim ed to compare the clinical efficacy of hexanic extract of SeR ( HESr ) versus non-HESr ( nHESr ) versus placebo versus alpha-blockers ( ABs ) in patients affected by LUTS secondary to BPE through a network meta- analysis method .
Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia
This study was to investigate the role of complementary and alternative medicine in the prevention and treatment of benign prostatic hyperplasia . For this purpose , a r and omized , double-blind , placebo-controlled trial was performed over 12 months on 47 benign prostatic hyperplasia patients with average age of 53.3 years and international prostate symptom score over 8 . Subjects received either sweet potato starch ( group A , placebo , 320 mg/day ) , pumpkin seed oil ( group B , 320 mg/day ) , saw palmetto oil ( group C , 320 mg/day ) or pumpkin seed oil plus saw palmetto oil ( group D , each 320 mg/day ) . International prostate symptom score , quality of life , serum prostate specific antigen , prostate volume and maximal urinary flow rate were measured . In groups B , C and D , the international prostate symptom score were reduced by 3 months . Quality of life score was improved after 6 months in group D , while those of groups B and C were improved after 3 months , compared to the baseline value . Serum prostate specific antigen was reduced only in group D after 3 months , but no difference was observed in prostate volume in all treatment groups . Maximal urinary flow rate were gradually improved in groups B and C , with statistical significance after 6 months in group B and after 12 months in group C. None of the parameters were significantly improved by combined treatment with pumpkin seed oil and saw palmetto oil . From these results , it is suggested that administrations of pumpkin seed oil and saw palmetto oil are clinical ly safe and may be effective as complementary and alternative medicine treatments for benign prostatic hyperplasia
In this network meta- analysis , we demonstrated that SeR did not show clinical ly meaningful improvement in LUTS and PF .
PATIENT SUMMARY In the present study , we found no clinical ly meaningful improvement of Serenoa repens for the treatment of lower urinary tract symptoms/benign prostatic enlargement .
CONTEXT International guidelines do not make any specific recommendations on Serenoa repens ( SeR ) for the treatment of male lower urinary tract symptoms ( LUTS ) secondary to benign prostatic enlargement ( BPE ) , due to product heterogeneity and method ological limitations of the published trials and meta-analyses .
OBJECTIVE We aim ed to compare the clinical efficacy of hexanic extract of SeR ( HESr ) versus non-HESr ( nHESr ) versus placebo versus alpha-blockers ( ABs ) in patients affected by LUTS secondary to BPE through a network meta- analysis method .