Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .
A randomized, placebo-controlled trial on the effects of soy protein containing isoflavones on quality of life in postmenopausal women
Objective : Postmenopausal estrogen decline is implicated in several age-related physical and psychological changes in women , including decreases in perceived quality of life ( QoL ) . A number of trials with hormone therapy showed beneficial effects of the intervention on parameters of quality of life . However , because of known or suspected serious side-effects of conventional hormone therapy there is a need for alternatives . Design : We conducted a double-blind r and omized placebo-controlled trial with soy protein , containing 52 mg genistein , 41 mg daidzein , and 6 mg glycitein ( aglycone weights ) , or milk protein ( placebo ) daily for 1 year . For this trial , we recruited 202 postmenopausal women aged 60 to 75 years . Results : At baseline and at final visit , participants filled in the Short Form of 36 questions ( SF-36 ) , the Question naire on Life Satisfaction Modules ( QLSM ) , and the Geriatric Depression Scale ( GDS ) . For the placebo group scores on all dimensions of the SF-36 and the QLSM decreased during the intervention year , except for the dimension " role limitations caused by physical problems . " The soy group showed increases on two dimensions of the SF-36 ( " social functioning " and " role limitations caused by physical problems " ) and on one dimension of the QLSM . There were however no statistically significant differences in changes of scores between the two intervention groups . For the GDS similarly , no significant differences were found between the groups . Conclusions : In conclusion , the findings in this r and omized trial do not support the presence of a marked effect of soy protein substitution on quality of life ( health status , life satisfaction , and depression ) in elderly postmenopausal women
Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .