We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
The timing and duration of a sensitive period in human flavor learning: a randomized trial.
BACKGROUND By using the response to protein hydrolysate formula ( PHF ) as a model system , we discovered the existence of a sensitive period , before 4 mo , when exposure determines the hedonic tone to flavors . OBJECTIVE We aim ed to characterize the timing and duration of this sensitive period . DESIGN Healthy infants , whose parents had chosen formula feeding , were r and omly assigned into 1 of 6 groups at age 0.5 mo : 2 control groups , one fed cow milk-based formula ( CMF ) and the other fed PHF for 7 mo ; 2 groups fed PHF for either 1 or 3 mo beginning at 1.5 mo and CMF otherwise ; and 2 groups fed PHF for 1 mo beginning at either 2.5 or 3.5 mo and CMF otherwise . Brief access taste tests were conducted monthly , and complete " meals " of both formulas occurred at the end of the study . RESULTS Three months of PHF exposure led to acceptance similar to that at 1 mo of exposure . Although these infants were more accepting than were infants with no exposure , they were less accepting than were infants with 7 mo of exposure , which suggests a dosing effect . The time when flavor experiences began was also significant . Among infants exposed to PHF for 1 mo , those who were first fed PHF at 3.5 mo rejected PHF relative to CMF more than did infants exposed at younger ages . CONCLUSION The general principles observed are likely of broader significance , indicating a fundamental feature of mammalian development and reflecting the importance of familiarizing infants with flavors that their mothers consume and transmit to breast milk . This trial was registered at clinical trials.gov as NCT00994747
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .