Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .
Sleep Apnea Determines Soluble TNF-α Receptor 2 Response to Massive Weight Loss
Background The effects of surgical weight loss ( WL ) on inflammatory biomarkers associated with sleep apnea  remain unknown . We sought to determine if any biomarkers can predict amelioration of sleep apnea achieved by bariatric surgery . We hypothesized that surgical WL would substantially reduce severity of sleep apnea and levels of proinflammatory cytokines . Methods Twenty-three morbidly obese adults underwent anthropometric measurements , polysomnography , and serum biomarker profiling  prior to and 1 year following bariatric surgery .  We examined the effect of WL and amelioration of sleep apnea on metabolic and inflammatory markers . Results Surgical WL result ed in significant decreases in BMI ( 16.7 ± 5.97 kg/m2/median 365 days ) , apnea – hypopnea index ( AHI ) , CRP , IL-6 , sTNFαR1 , sTNFαR2 , and leptin levels , while ghrelin , adiponectin , and soluble leptin receptor concentrations increased significantly . Utilizing an AHI cutoff of 15 events/h , we found significantly elevated levels of baseline sTNFαR2 and greater post-WL sTNFαR2 decreases in subjects with baseline AHI ≥15 events/h compared to those with AHI < 15 events/h despite no significant differences in baseline BMI , age , and Δ BMI . In a multivariable linear regression model adjusting for sex , age , impaired glucose metabolism , Δ BMI , and follow-up period , the post-WL decreases in AHI were an independent predictor of the decreases in sTNFαR2 and altogether accounted for 46 % of the variance of ΔsTNFαR2 ( P = 0.011 ) in the entire cohort . Conclusions Of all the biomarkers , the decrease in sTNFαR2 was independently determined by the amelioration of sleep apnea achieved by bariatric surgery . The results suggest that sTNFαR2 may be a specific sleep apnea biomarker across a wide range of body weight
Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .