Combination therapy studies of third-line treatments were rare and centered on medication with PTNS .
Combination therapy , with certain first , second , and third-line OAB therapies , appears to be efficacious .
AIMS Overactive bladder ( OAB ) affects over 17 % of the population and significantly effect the health-related quality of life .
The treatments for OAB include first line ( lifestyle modification , pelvic floor muscle training ) , second line ( anticholinergic or beta-3 agonist medications ) , and third line therapies ( intradetrusor botulinum toxin injection , sacral neurostimulation [ SNM ] , or percutaneous tibial nerve stimulation [ PTNS ] ) .
For those with urinary incontinence secondary to OAB , complete continence is the goal of therapy , though cure rates are only 5 % to 40 % .
The use of combination therapies can be employed in refractory OAB , however , the efficacy of pooled modalities is relatively unknown .
Our objective was to determine the volume of data supporting combination therapy in treating OAB .
The effects of drug and behavior therapy on urgency and voiding frequency
Introduction and hypothesisThe objective of this study was to examine the effects of drug therapy alone and combined with behavioral therapy on urgency and 24-voiding frequency in women with urge-predominant incontinence and to identify predictors of change . Methods A planned analysis of data from a multi-site , r and omized , controlled trial ( N = 307 ) . Bladder diaries were used to document voids , incontinence , and urgency severity . Results Urgency scores decreased significantly within both treatment groups , but changes did not differ between groups ( p = 0.30 ) . Improvement in urgency was associated with greater baseline urgency ( p < 0.0001 ) and black ethnicity ( p = 0.03 ) . Voiding frequency increased with drug alone and decreased slightly with combined therapy ( p = 0.009 ) , and improvement was associated with combined treatment ( p < 0.0001 ) , higher baseline frequency ( p < 0.0001 ) , and lower baseline incontinence episode frequency ( p = 0.001 ) . Conclusions Although combined drug and behavioral therapy does not appear to improve urgency more than drug alone , it result ed in better outcomes on voiding frequency
Combination therapy studies of third-line treatments were rare and centered on medication with PTNS .
Combination therapy , with certain first , second , and third-line OAB therapies , appears to be efficacious .
AIMS Overactive bladder ( OAB ) affects over 17 % of the population and significantly effect the health-related quality of life .
The treatments for OAB include first line ( lifestyle modification , pelvic floor muscle training ) , second line ( anticholinergic or beta-3 agonist medications ) , and third line therapies ( intradetrusor botulinum toxin injection , sacral neurostimulation [ SNM ] , or percutaneous tibial nerve stimulation [ PTNS ] ) .
For those with urinary incontinence secondary to OAB , complete continence is the goal of therapy , though cure rates are only 5 % to 40 % .
The use of combination therapies can be employed in refractory OAB , however , the efficacy of pooled modalities is relatively unknown .
Our objective was to determine the volume of data supporting combination therapy in treating OAB .