Conclusions Systematic identification of new-onset arrhythmias following TAVI may have considerable impact on subsequent therapeutic management and long-term prognosis in this patient population
Objective To evaluate the prevalence and clinical impact of new-onset arrhythmias in patients following transcatheter aortic valve implantation ( TAVI ) .
Periprocedural bleeding, acute kidney injury, and long-term mortality after transcatheter aortic valve implantation.
BACKGROUND  Acute kidney injury (  AKI ) after transcatheter aortic valve implantation ( TAVI )  is frequent and is associated with adverse outcomes . Past studies have attributed AKI to impaired kidney function at baseline , amount of contrast medium used , major bleeding , and hemodynamic instability during the procedure . Because major bleeding might play a role in the development of AKI , we analyzed the relationship between periprocedural bleeding and the development of AKI and assessed the impact of these 2 important procedure-related complications on outcome . METHODS Consecutive patients undergoing transfemoral TAVI for severe aortic stenosis were prospect ively recruited .  AKI and bleeding events during hospitalization were recorded , defined , and classified according to the Valve Academic Research Consortium 2 definitions . Logistic and Cox regression was used for predictor and survival analyses . RESULTS We recruited 422 consecutive patients who underwent TAVI ; the mean follow-up duration was 576 ± 400 days . AKI occurred in 66 ( 15.6 % ) patients . No patient required dialysis . Fifty patients ( 12 % ) had major or life-threatening bleeding . Periprocedural major or life-threatening bleeding was a strong predictor of the development of AKI ( odds ratio , 3.19 ; 95 % confidence interval [ CI ] , 1.38 - 7.1 ; P = 0.006 ) . Major bleeding was a strong independent predictor for both 30-day and long-term mortality ( hazard ratio [ HR ] , 6.67 ; 95 % CI , 2.2 - 19.8 ; P = 0.001 and HR , 3.3 , 95 % CI , 1.2 - 9.0 ; P = 0.02 , respectively ) , whereas AKI was not independently associated with increased mortality after TAVI . CONCLUSIONS In patients undergoing transfemoral TAVI  , periprocedural bleeding is a strong risk factor for the development of AKI and a major determinant of short- and long-term mortality
Conclusions Systematic identification of new-onset arrhythmias following TAVI may have considerable impact on subsequent therapeutic management and long-term prognosis in this patient population
Objective To evaluate the prevalence and clinical impact of new-onset arrhythmias in patients following transcatheter aortic valve implantation ( TAVI ) .