Monotherapy with either fibrates or statins suggested a significantly greater effect of fibrates in lowering plasma Fib concentrations .
According to these findings , mechanisms associated with fibrinogen metabolism might be responsible for the distinct effects of statins and fibrates in reducing cardiovascular endpoints
BACKGROUND Several studies suggest differences between fibrates and statins in lowering plasma fibrinogen ( Fib ) concentrations , but the evidence is not definitive .
Therefore , the aim of this meta- analysis of head-to-head r and omized trials was to compare the efficacy of statins and fibrates on plasma Fib concentrations .
A randomized pilot trial of low‐dose combination lipid‐lowering therapy following coronary artery bypass grafting
Vein graft atherosclerosis is a common and serious complication of coronary artery bypass grafting ( CABG ) . There is mounting evidence that lipoprotein abnormalities play an equally important role in the development of lesions in saphenous vein grafts after CABG as in native coronary vessel disease . The potential benefit of low‐dose lipid lowering combination therapy in these patients has not been investigated . In a r and omized , double‐blind , placebo‐controlled study , we compared the efficacy and safety of a low‐dose combination of colestipol 10 g and simvastatin 10 mg/day ( CS ) to colestipol 10 mg and bezafibrate 400 mg/day ( CB ) for 2 months in 33 patients with serum total cholesterol > 6.5 mmol/l and triglyceride < 4.5 mmol/l who had undergone CABG for severe coronary artery disease . In the CS group , total cholesterol decreased by 29 % and low‐density lipoprotein ( LDL ) cholesterol by 42 % ; similarly , CB reduced total cholesterol by 17 % , LDL cholesterol by 23 % , triglyceride by 19 % , and increased high‐density lipoprotein ( HDL ) cholesterol by 14 % . Lipoprotein ( a ) and hemostatic factors were unaffected by either therapy in this study . Both combination therapies were well tolerated with no significant clinical or biochemical side effects . We conclude that low‐dose combinations of colestipol and simvastatin or colestipol and bezafibrate are effective and well tolerated in the management of moderate hyperlipidemia in patients who had undergone CABG
Monotherapy with either fibrates or statins suggested a significantly greater effect of fibrates in lowering plasma Fib concentrations .
According to these findings , mechanisms associated with fibrinogen metabolism might be responsible for the distinct effects of statins and fibrates in reducing cardiovascular endpoints
BACKGROUND Several studies suggest differences between fibrates and statins in lowering plasma fibrinogen ( Fib ) concentrations , but the evidence is not definitive .
Therefore , the aim of this meta- analysis of head-to-head r and omized trials was to compare the efficacy of statins and fibrates on plasma Fib concentrations .