While no clinical trial to date has specifically targeted fatigue , r and omized controlled trials , systematic review s , and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue .
Fatigue is a disabling , multifaceted symptom that is highly prevalent and stubbornly persistent .
Although fatigue is a frequent complaint among patients with fibromyalgia , it has not received the same attention as pain .
Reasons for this include lack of st and ardized nomenclature to communicate about fatigue , lack of evidence -based guidelines for fatigue assessment , and a deficiency in effective treatment strategies .
Fatigue does not occur in isolation ; rather , it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain , unrefreshing sleep , anxiety , depression , cognitive difficulties , and so on .
Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms .
Sodium oxybate reduces pain, fatigue, and sleep disturbance and improves functionality in fibromyalgia: Results from a 14-week, randomized, double-blind, placebo-controlled study
& NA ; This 14‐week , phase 3 , double‐blind , r and omized , controlled trial evaluated sodium oxybate ( SXB ) 4.5 and 6 g per night versus placebo in patients with fibromyalgia ( FM ) .  SXB is the sodium salt of γ‐hydroxybutyrate ( GHB ) . GHB is an endogenous compound , synthesized from γ‐aminobutyric acid ( GABA ) and found broadly in the central nervous system and body . Among 548 r and omized patients , a ⩾30 % reduction in pain was experienced by 54.2 % and 58.5 % of patients treated with SXB 4.5 and 6 g , respectively , versus 35.2 % for placebo with a 100‐mm Visual Analog Scale ( VAS ) ( P < 0.001 for both comparisons ) . Relative to placebo , both SXB doses significantly reduced fatigue ( with a 100‐mm VAS ; P < 0.001 ) and sleep disturbance ( with the Jenkins Sleep Scale ; P < 0.001 ) , and result ed in significant improvements in function as measured by the FM Impact Question naire ( P = 0.003 and P = 0.001 for 4.5 and 6 g per night , respectively ) . On the Short‐Form 36 Health Survey , SXB‐related improvement was significant on the Physical , but not the Mental , Component Scale . The proportion of patients who reported a global improvement of “ much ” or “ very much ” better on the Patient Global Impression of Change was significantly greater in both SXB groups versus placebo ( P < 0.001 ) . Headache , nausea , dizziness , vomiting , diarrhea , anxiety , and sinusitis were the most commonly reported adverse events , with an incidence at least twice that of placebo . These results exp and the evidence from previous clinical trials suggesting that SXB is effective and safe in FM . This study exp and s evidence from previous trials that sodium oxybate provides safe , effective treatment for multiple symptoms experienced by patients with fibromyalgia
While no clinical trial to date has specifically targeted fatigue , r and omized controlled trials , systematic review s , and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue .
Fatigue is a disabling , multifaceted symptom that is highly prevalent and stubbornly persistent .
Although fatigue is a frequent complaint among patients with fibromyalgia , it has not received the same attention as pain .
Reasons for this include lack of st and ardized nomenclature to communicate about fatigue , lack of evidence -based guidelines for fatigue assessment , and a deficiency in effective treatment strategies .
Fatigue does not occur in isolation ; rather , it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain , unrefreshing sleep , anxiety , depression , cognitive difficulties , and so on .
Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms .