We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .
N-3 fatty acid supplementation to routine statin treatment inhibits platelet function, decreases patients’ daytime blood pressure, and improves inflammatory status
Objectives N-3 fatty acids reduce the risks of cardiovascular morbidity and mortality . Administration of N-3 fatty acids to patients treated with statins  may potentiate the treatment effects . We examined the operating mechanisms underlying such a combination . Methods Thirty-two hypercholesterolemic patients aged 30–70 years with hypercholesterolemia controlled by statins  , received sequential treatments with placebo followed by 1.9 g/day of N-3 fatty acids for 23 weeks . Scheduled clinical visits included physical examination , 24-h blood pressure measurement , endothelial function evaluated by pulse wave analysis , analyses for platelet function , inflammation markers [ interleukin (IL)-6 , plasminogen activator inhibitor-1 ( PAI-1 ) ] and oxidative stress parameters ( STAT-8-Isoprostane ) were undertaken at baseline , after placebo treatment , and after 6 and 20 weeks of N-3 fatty acid intake . Results Platelets functions were significantly inhibited , whereas endothelial function parameters were unaltered . IL-6 significantly decreased whereas PAI-1 and STAT-8-Isoprostane levels remained unaffected . Daytime blood pressure significantly decreased ; however , nighttime pressure and heart rate remained unchanged . No evidence of lipid-profile improvement was observed following combined treatment with statins and N-3 fatty acids . Conclusions In hypercholesterolemic patients , combination of statins and N-3 fatty acid inhibits platelet aggregation , alters inflammatory status , and positively affects daytime blood pressure . Close long-term follow-up might reveal additional beneficial effects of N-3 fatty acids in this patient population
We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .