With significantly higher efficacy and low complication rates , appendectomy remains the most effective treatment for patients with uncomplicated AA .
BACKGROUND Acute appendicitis is the most common surgical diagnosis in young patients , with lifetime prevalence of about 7 % .
Debate remains on whether uncomplicated AA should be operated or not .
Aim of this meta- analysis of r and omized controlled trials was to assess current evidence on antibiotic treatment for uncomplicated AA compared to st and ard surgical treatment .
T.E.A. Study: three-day ertapenem versus three-day Ampicillin-Sulbactam
Background Intra-abdominal infections are one of the most common infections encountered by a general surgeon . However , despite this prevalence , st and ardized guidelines outlining the proper use of antibiotic therapy are poorly defined due to a lack of clinical trials investigating the ideal duration of antibiotic treatment . The aim of this study is to compare the efficacy and safety of a three-day treatment regimen of Ampicillin-Sulbactam to that of a three-day regimen of Ertapenem in patients with localized peritonitis ranging from mild to moderate severity . Methods This study is a prospect i ve , multi-center , r and omized investigation performed in the Department of General , Emergency , and Transplant Surgery of St. Orsola-Malpighi University Hospital in Bologna , Italy . Discrete data were analyzed using the Chi-squared and Fisher exact tests . Differences between the two study groups were considered statistically significant for p-values less than 0.05 . Results 71 patients were treated with Ertapenem and 71 patients were treated with Ampicillin-Sulbactam .  The two groups were comparable in terms of age and gender as well as the site of abdominal infection . Post-operative infection was identified in 12 patients : 10 with wound infections and 2 with intra-abdominal infections . In the Ertapenem group , 69 of the 71 patients ( 97 % ) were treated successfully , while the therapy failed in 2 cases ( 3 % ) . Therapy failures were more frequent in the Unasyn group , amounting to 10 of 71 cases ( p = 0.03 ) . Conclusion According to these preliminary findings , the authors conclude that a three-day Ertapenem treatment regimen is the most effective antibiotic therapy for patients with localized intra-abdominal infections ranging from mild to moderate severity . Trial registration Trial registration : Clinical Trials.gov :
With significantly higher efficacy and low complication rates , appendectomy remains the most effective treatment for patients with uncomplicated AA .
BACKGROUND Acute appendicitis is the most common surgical diagnosis in young patients , with lifetime prevalence of about 7 % .
Debate remains on whether uncomplicated AA should be operated or not .
Aim of this meta- analysis of r and omized controlled trials was to assess current evidence on antibiotic treatment for uncomplicated AA compared to st and ard surgical treatment .