Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .
Clinical Efficacy of Alprostadil Combined with α-lipoic Acid in the Treatment of Elderly Patients with Diabetic Nephropathy
Abstract Objective To evaluate the effect and toxicity of alprostadil combined with thioctic acid injection in the treatment of patients with diabetic nephropathy ( DN ) . Methods Sixty two patients with DN were included in this study and r and omly divided into control group ( n=32 ) and experiment group ( n=30 ) . Patients in the control group were given alprostadil 20ug+NS 100ml ivgtt , qd and patients in the experiment group were given alprostadil 20ug+NS 100ml ivgtt combined with thioctic acid injection of 0.45g+100ml ivgtt , qd for 14 days . After treatment , the renal function and serum level of CRP , IL-6 and TNF-α were compared between the two groups . Results After two weeks of treatment , the serum level of CysC and UAER significant decreased for both control and experiment group with statistical difference of p<0.05 . After treatment , the serum level of CysC were 1.40 ±0.46 mg/L and 1.02±0.33 for control and experiment group respectively ( p<0.05 ) . The post-treatment UAER in experiment group was significantly lower than those of control group with statistical difference ( 81.02±0.33 vs112.45±20.32 , p<0.05 ) ug/min . The serum level of CRP , IL-6 and TNF-α were significantly decreased after treatment for both control and experiment group ( p<0.05 ) . And the post-treatment serum CRP , IL-6 and TNF-α in experiment group were significantly lower than those of control group with statistical difference ( p<0.05 ) . No significant side effects were found for the two groupsin the course of treatment . Conclusion Alprostadil combined with α-lipoic acid may improve  renal function in patients with diabetic nephropathy by decreasing the levels of serum inflammatory factors
Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .