No significant changes were observed for blood lipids , anthropometric measures , HbA1c and fasting glucose .
The present systematic review provides evidence for beneficial effects of long-term interventions administering a low glycemic index/load diet with respect to fasting insulin and pro-inflammatory markers such as C-reactive protein which might prove to be helpful in the primary prevention of obesity-associated diseases
AIM The aim of the present meta- analysis was to investigate the long-term effects of glycemic index-related diets in the management of obesity with a special emphasis on the potential benefits of low glycemic index/load ( GI/GL ) in the prevention of obesity-associated risks .
A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults.
Low-glycemic index diets and exercise independently improve glucose tolerance and reduce diabetes risk . However , the combined effect of a low-glycemic index diet and exercise on inflammation and glucose metabolism is not known . Therefore , we r and omized 28 insulin-resistant adults ( age : 66 ± 1 y ; BMI : 34.2 ± 0.7 kg · m(-2 ) ) to a 12-wk , low ( LGI = 40 ) or high- ( HGI = 80 ) glycemic index diet plus aerobic exercise  ( 5 d · wk(-1 ) , 60 min · d(-1 ) , 80 - 85 % heart rate(max ) ) intervention . All food and fluids were provided during the study . Inflammation was assessed from cytokine ( TNFα and IL-6 ) secretion using peripheral blood mononuclear cells ( MNC ) stimulated overnight with LPS . Glycemic response was determined following ingestion of a 75-g glucose solution . Fasting blood sample s were collected for additional cytokine [ TNFα , IL-6 , and monocyte chemoattractant protein 1 ( MCP-1 ) ] analysis . Both interventions decreased BMI ( P < 0.001 ) , fasting plasma glucose ( P = 0.01 ) , and insulin ( P = 0.02 ) . The glycemic response was reduced only in the LGI group ( P = 0.04 ) . Plasma and MNC-derived TNFα secretion were reduced in the LGI group ( P = 0.02 ) but increased in the HGI group ( P = 0.02 ) . Secretion of IL-6 from MNC and plasma IL-6 and MCP-1 concentrations were reduced in the LGI group . The change in MNC-derived TNFα ( r = 0.43 ; P = 0.04 ) and plasma MCP-1 ( r = 0.44 ; P = 0.04 ) correlated with decreases in the glycemic response . These data highlight the importance of diet composition in the treatment and prevention of inflammation and hyperglycemia . A low-glycemic index diet has antiinflammatory and antidiabetogenic effects when combined with exercise in older , obese prediabetics
No significant changes were observed for blood lipids , anthropometric measures , HbA1c and fasting glucose .
The present systematic review provides evidence for beneficial effects of long-term interventions administering a low glycemic index/load diet with respect to fasting insulin and pro-inflammatory markers such as C-reactive protein which might prove to be helpful in the primary prevention of obesity-associated diseases
AIM The aim of the present meta- analysis was to investigate the long-term effects of glycemic index-related diets in the management of obesity with a special emphasis on the potential benefits of low glycemic index/load ( GI/GL ) in the prevention of obesity-associated risks .