( S ) Few studies of medical therapies for endometriosis report outcomes that are relevant to patients , and many women gain only limited or intermittent benefit from treatment
OBJECTIVE To assess patient response rates to medical therapies used to treat endometriosis-associated pain .
A comparative study of the acceptability and effect of goserelin and nafarelin on endometriosis
The effects of goserelin and nafarelin were compared in a prospect i ve , r and omized , open , parallel study of 6 months ' treatment of 252 women with symptomatic , laparoscopically proven endometriosis . Twenty-eight departments of obstetrics and gynecology in Sweden , Norway , Denmark and Finl and were included . Evaluations were made every 3 months for quantification of pain , bleeding and adverse events and convenience of treatment , and at 3 months after the end of treatment , when a control laparoscopy was performed for evaluation of changes in endometriotic lesion size , color and location . Thirty-nine patients withdrew and 113 women given goserelin and 100 women given nafarelin completed the study . There were no statistically significant differences between the groups , either in adverse events or in bleeding . There were no correlations between location , lesion size or type of lesion , and symptom score in either group , or between treatments with regard to change in endometriosis score . In both groups , the percentage of red and black lesions was reduced while the proportion of white lesions increased . The pain score was significantly reduced in both groups . Local irritation in the nasal mucosa was reported in both groups , mostly in the nafarelin-treated group . The goserelin-treated group also reported local symptoms at the injection site . We conclude that there is no statistically significant difference in treatment results or side-effects between goserelin and nafarelin when used for the treatment of endometriosis
( S ) Few studies of medical therapies for endometriosis report outcomes that are relevant to patients , and many women gain only limited or intermittent benefit from treatment
OBJECTIVE To assess patient response rates to medical therapies used to treat endometriosis-associated pain .