Moreover , subgroup analyses suggested that the effects of glycemic control were significantly influenced by the sex of the subjects and the type and the method of intake of ITF .
Conclusions Our analyses confirmed that these four main glycemic indicators were significantly reduced by ITF supplementation , particularly in the prediabetes and T2DM population .
Evidence supports that reasonable administration of ITF supplementation may have potential clinical value as an adjuvant therapy for prediabetes and T2DM management .
Background Currently , many clinical trials have shown that inulin-type fructans ( ITF ) supplementation is associated with glycemic control ; nevertheless , the results are inconclusive .
The aim of this meta- analysis of r and omized controlled trials was to assess the effects of ITF supplementation on glycemic control .
Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals.
BACKGROUND & AIMS The gut microbiota affects host lipid and glucose metabolism , satiety , and chronic low- grade inflammation to contribute to obesity and type 2 diabetes . Fermentation end products , in particular the short-chain fatty acid ( SCFA ) acetate , are believed to be involved in these processes . We investigated the long-term effects of supplementation with galacto-oligosaccharides ( GOS ) , an acetogenic fiber , on the composition of the human gut microbiota and human metabolism . METHODS We performed a double-blinded , placebo-controlled , parallel intervention study of 44 overweight or obese ( body mass index , 28 - 40 kg/m2 ) prediabetic men and women ( ages , 45 - 70 y ) from October 2014 through October 2015 in Maastricht , The Netherl and s. The participants were assigned r and omly to groups who ingested 15 g GOS or isocaloric placebo ( maltodextrin ) daily with their regular meals for 12 weeks . Before and after this period , we collected data on peripheral and adipose tissue insulin sensitivity , fecal microbiota composition , plasma and fecal SCFA , energy expenditure and substrate oxidation , body composition , and hormonal and inflammatory responses . The primary outcome was the effect of GOS on peripheral insulin sensitivity , measured by the hyperinsulinemic-euglycemic clamp method . RESULTS Supplementation of diets with GOS , but not placebo , increased the abundance of Bifidobacterium species in feces by 5-fold ( P = .009 ; q = 0.144 ) . Microbial richness or diversity in fecal sample s were not affected . We did not observe any differences in fecal or fasting plasma SCFA concentrations or in systemic concentrations of gut-derived hormones , incretins , lipopolysaccharide-binding protein , or other markers of inflammation . In addition , no significant alterations in peripheral and adipose tissue insulin sensitivity , body composition , and energy and substrate metabolism were found . CONCLUSIONS Twelve-week supplementation of GOS selectively increased fecal Bifidobacterium species abundance , but this did not produce significant changes in insulin sensitivity or related substrate and energy metabolism in overweight or obese prediabetic men and women . ClincialTrials.gov number , NCT02271776
Moreover , subgroup analyses suggested that the effects of glycemic control were significantly influenced by the sex of the subjects and the type and the method of intake of ITF .
Conclusions Our analyses confirmed that these four main glycemic indicators were significantly reduced by ITF supplementation , particularly in the prediabetes and T2DM population .
Evidence supports that reasonable administration of ITF supplementation may have potential clinical value as an adjuvant therapy for prediabetes and T2DM management .
Background Currently , many clinical trials have shown that inulin-type fructans ( ITF ) supplementation is associated with glycemic control ; nevertheless , the results are inconclusive .
The aim of this meta- analysis of r and omized controlled trials was to assess the effects of ITF supplementation on glycemic control .