None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .
Insulin therapy of hyperglycemia in intensive care.
BACKGROUND Hyperglycemia is common among patients admitted to intensive care units , and carries the risk for complications and prolonged ICU stay . With intensive insulin control of blood glucose , morbidity and mortality can be reduced . OBJECTIVES To determine whether intensive or conventional insulin control of blood glucose in hyperglycemic ICU patients correlated with the prognosis . METHODS Following admission to the ICU , hyperglycemic patients were r and omly assigned to a group treated intensively with insulin targeting glucose at 110 - 140 mg/dl , or to a conventional insulin therapy group , where glucose , upon exceeding 200 mg/dl , was controlled at 140 - 200 mg/dl . Rates of morbidity and mortality , hypoglycemic episodes , and insulin dosage were compared . RESULTS In the 41 patients treated intensively with insulin  the glucose level was 142 + /- 14 mg/dl , as compared to 174+/-20 mg/dl in the 48 patients on conventional insulin treatment .  Both groups were similar in age , acute physiology and chronic health evaluation score . Morbidity was also similar , except for increased vascular damage in the conventional treatment group and slightly shorter ICU stay in the intensive therapy group . Both groups had similar in-ICU , in-hospital , and 28 day mortalities , and similar rates of hypoglycemic episodes . The daily dosage of insulin  was significantly higher with the conventional treatment ( P= 0.004 ) . CONCLUSIONS Intensive insulin treatment did not affect the mortality or morbidity rates in ICU patients . The increased  insulin dosage of conventional insulin treatment was attributable to the group 's higher prevalence of diabetes . Future studies should address this bias and determine the optimal glucose target
None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .