This meta- analysis concludes that hypovitaminosis D is associated with increased risk of hyperglycemia both in diabetic and non-diabetic subjects .
There is evidence that vitamin D status is associated with type 2 diabetes .
Many observational studies have been performed investigating the relationship of vitamin D status and circulating biomarkers of glycemic regulation .
To find out whether this association holds , we conducted a systematic review and meta- analysis of cross sectional and longitudinal studies .
Relationship between glycated hemoglobin and circulating 25-hydroxyvitamin D concentration in African American and Caucasian American men.
OBJECTIVES To examine whether ( 1 ) serum 25-hydroxyvitamin D level ( 25[OH]D ) is a risk factor for hyperglycemia , as assessed by glycated hemoglobin ( HbA1c ) , in African American men ( AAM ) and ( 2 ) 25(OH)D is a predictor of HbA1c in AAM and Caucasian American men ( CAM ) . METHODS We prospect ively assessed 25(OH)D and HbA1c in 1,074 men , out patients with and without diabetes , at an urban Veteran Administration Medical Center ( 66.8 % AAM , 26.4 % CAM , 6 % Hispanic , 0.4 % Asian , and 0.4 % Native American men ) . Multivariate regression analyzed the determinants of HbA1c after accounting for potential confounders . RESULTS We found high prevalence of low ( < 30 ng/mL ) 25(OH)D ( 81 % ) and elevated ( ≥5.7 % ) HbA1c ( 53.5 % ) . The 25(OH)D was inversely associated with HbA1c in all men ( r = -0.12 , P<.001 ) , in AAM ( r = -0.11 , P = .003 ) , and in CAM ( r = -0.15 , P = .01 ) . In the entire group the independent determinants of HbA1c included body mass index ( BMI ) , age , 25(OH)D levels , systolic blood pressure ( BP ) , triglycerides , high-density lipoprotein ( HDL ) , and current alcohol use ( P<.0001 , .013 , .009 , .01 , .008 , .034 , and .048 , respectively ) while glomerular filtration rate ( GFR ) and marital status showed borderline significance ( P = .08 and .09 , respectively ) . In AAM these determinants included BMI , 25(OH)D levels , systolic BP , and current alcohol use ( P<.0001 , .01 , .02 , and .03 , respectively ) , while age had borderline significance ( P = .06 ) . In CAM , these included BMI , age , and triglycerides ( P = .01 , .03 , and .004 , respectively ) but not 25(OH)D levels ( P = .50 ) . CONCLUSION Circulating low 25(OH)D is a risk factor for hyperglycemia , as assessed by HbA1c , in AAM . The 25(OH)D level is an independent determinant of HbA1c in AAM , but not in CAM , including men with and without diabetes
This meta- analysis concludes that hypovitaminosis D is associated with increased risk of hyperglycemia both in diabetic and non-diabetic subjects .
There is evidence that vitamin D status is associated with type 2 diabetes .
Many observational studies have been performed investigating the relationship of vitamin D status and circulating biomarkers of glycemic regulation .
To find out whether this association holds , we conducted a systematic review and meta- analysis of cross sectional and longitudinal studies .