Conclusions : Antibiotic prophylaxis did confer a reduction in cases of symptomatic and asymptomatic bacteriuria but the NNT were high .
Introduction : The role of antibiotic prophylaxis for routine flexible cystoscopy ( FC ) is not clear due to the varying practice s of individual clinicians .
There are no formal guidelines , and this may be due to a lack of formal summary of the data .
Randomized trial of antibiotic prophylaxis for combined urodynamics and cystourethroscopy.
OBJECTIVE To determine the efficacy of prophylactic nitrofurantoin in preventing bacteriuria after urodynamics and cystourethroscopy . METHODS We assumed that nitrofurantoin prophylaxis would decrease the rate of infection after urodynamics and cystourethroscopy from 19 % to 5 % . All women presenting for urodynamics and cystourethroscopy during a 27-month period were offered enrollment , and 142 were r and omly assigned to receive two doses of long-acting nitrofurantoin 100 mg ( n = 74 ) , or two doses of placebo ( n = 68 ) . Nitrofurantoin and placebo capsules were identical , and subjects and physicians were masked to group assignment . Differences were assessed using Student t test for continuous data and chi2 analysis for dichotomous data . RESULTS There were no statistical differences in demographic characteristics or final diagnoses between groups . Seven women ( 5 % ) who had bacteriuria on initial urine culture were not included in the final analysis . The frequency of bacteriuria in the postinstrumentation urine cultures was 6 % overall , 7 % in the treatment group , and 5 % in the controls , a nonsignificant difference ( [ relative risk ] 1.49 , [ confidence interval ] 0.37 , 5.95 ) . The power of the study was 33 % to detect a significant difference . CONCLUSION Bacteriuria after combined urodynamics and cystourethroscopy was not improved by a 1-day course of nitrofurantoin
Conclusions : Antibiotic prophylaxis did confer a reduction in cases of symptomatic and asymptomatic bacteriuria but the NNT were high .
Introduction : The role of antibiotic prophylaxis for routine flexible cystoscopy ( FC ) is not clear due to the varying practice s of individual clinicians .
There are no formal guidelines , and this may be due to a lack of formal summary of the data .