No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .
A Randomized Double-Masked Study of 0.05% Cyclosporine Ophthalmic Emulsion in the Treatment of Meibomian Gland Dysfunction
Purpose : To compare the efficacy of topical cyclosporine [ 0.05 % cyclosporine A ( CsA ) ] and preservative-free artificial tears in the treatment of meibomian gl and dysfunction ( MGD ) . Methods : A 3-month prospect i ve , r and omized , double-masked , parallel-group controlled trial enrolled 70 patients with symptomatic MGD and unstable tear film [ tear breakup time ( TBUT ) < 8 seconds ] . Patients were r and omized to topical CsA ( 0.05 % ; group A ) and 0.5 % carboxymethylcellulose ( control ; group B ) instilled twice daily for 3 months . Ocular Surface Disease Index ( OSDI ) , lid margin inflammation , meibomian gl and expression , conjunctival injection , corneal and interpalpebral dye staining , noninvasive tear breakup time ( NIBUT ) using the Tearscope Plus and invasive fluorescein tear breakup time ( FBUT ) , and Schirmer I test were performed . Results : At the 3-month evaluation , mean OSDI , NIBUT and FBUT , lid margin inflammation , meibomian gl and expressibility , and tarsal injection showed significant improvement from baseline in group A ( P < 0.01 , P < 0.01 , P < 0.001 , P < 0.05 , and P < 0.001 , respectively ) . In group B , only the OSDI improved significantly from baseline at 3 months ( P = 0.003 ) . TBUTs ( NIBUT and FBUT ) were significantly longer in group A at all visits , and the mean change of TBUTs from baseline was also significantly greater in group A at 3 months ( P < 0.001 ) . Conclusions : Topical CsA 0.05 % twice daily may be helpful in the treatment of MGD mainly by improving tear film stability
No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .