There was a significant heterogeneity for the impact of CLA  on CRP and IL-6 , but not TNF-α .
Conclusions This meta- analysis showed that CLA supplementation may increase inflammatory markers ( CRP and TNF-α ) .
Background / objectives Conjugated linoleic acid ( CLA ) is a polyunsaturated fatty acid with attractive biological activities .
Numerous studies have been conducted on the inflammation-lowering effects of CLA in in vitro and animal models .
However , the effects of CLA treatment on the inflammatory markers in humans are controversial .
Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: a dietary intervention study.
BACKGROUND AND AIM Some studies recently reported a favourable effect for cis-9 , trans-11 conjugated linoleic acid ( CLA ) on plasma lipoprotein profile of healthy subjects . Aim of this crossover intervention study was to evaluate the influence of a short-term dietary intake of a cheese derived from sheep 's milk naturally rich in CLA on several atherosclerotic biomarkers , in comparison with a commercially available cheese . METHODS AND RESULTS Ten subjects ( 6 F ; 4 M ) with a median age of 51.5 followed for 10 weeks a diet containing 200 g/week of cheese naturally rich in CLA ( intervention period ) and for the same period a diet containing a commercially available cheese of the same quantity ( placebo period ) . Consumption of the dairy product naturally rich in cis-9 , trans-11 CLA determined a significant ( p<0.05 ) reduction in inflammatory parameters such as interleukin-6 ( pre : 8.08+/-1.57 vs. post : 4.58+/-0.94 pg/mL ) , interleukin-8 ( pre : 45.02+/-5.82 vs. post : 28.59+/-2.64 pg/mL ) , and tumour necrosis factor-alpha ( pre : 53.58+/-25.67 vs. post : 32.09+/-17.42 pg/mL ) whereas no significant differences in the placebo period were observed . With regard to haemorheological parameters , the test period significantly ameliorated erythrocytes ' filtration rate ( pre : 7.61+/-0.71 % vs. post : 9.12+/-0.97 % ; p=0.03 ) with respect to the placebo period . Moreover , a reduction in the extent of platelet aggregation , induced by arachidonic acid [ pre : 87.8+/-1.76 % vs. post : 77.7+/-3.56 % ; p=0.04 ] was observed during the test period in comparison with the placebo period . CONCLUSIONS Dietary short-term intake of the tested dairy product naturally rich in cis-9 , trans-11 CLA appeared to cause favourable biochemical changes of atherosclerotic markers
There was a significant heterogeneity for the impact of CLA  on CRP and IL-6 , but not TNF-α .
Conclusions This meta- analysis showed that CLA supplementation may increase inflammatory markers ( CRP and TNF-α ) .
Background / objectives Conjugated linoleic acid ( CLA ) is a polyunsaturated fatty acid with attractive biological activities .
Numerous studies have been conducted on the inflammation-lowering effects of CLA in in vitro and animal models .
However , the effects of CLA treatment on the inflammatory markers in humans are controversial .