In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
To evaluate and compare the efficacy of combined sucrose and non-nutritive sucking for analgesia in newborns undergoing minor painful procedure: a randomized controlled trial
Objective : The objective of this study was to evaluate and compare the efficacy of combined sucrose and non-nutritive sucking ( NNS ) for analgesia in newborn infants undergoing heel-stick procedures . Study Design : This r and omized control trial was conducted in the neonatal intensive care unit of a tertiary care hospital over a period of 1 year . One hundred and eighty full-term neonates with birth weight > 2200 g and age > 24 h were r and omized to one of four interventions administered 2 min before the procedure : 2 ml of 30 % sucrose ( group I , n=45 ) or NNS ( group II , n=45 ) or both ( group III , n=45 ) or none ( group IV , n=45 ) . Primary outcome was composite score based on Premature Infant Pain Profile ( PIPP ) score . Result : Baseline variables were comparable among the groups . Median ( interquartile range ) PIPP score was 3 ( 2 to 4 ) in group III as compared with 7 ( 6.5 to 8) in group I , 9 ( 7 to 11 ) in group II and 13 ( 10.5 to 15 ) in group IV . Group III had significant decrease in the median PIPP score compared with other groups ( P=0.000 ) . Median PIPP score also decreased significantly with any intervention as compared with no intervention ( P=0.000 ) . Conclusion : Sucrose and /or NNS are effective in providing analgesia in full-term neonates undergoing heel-stick procedures , with the combined intervention being more effective compared with any single intervention
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .