Adherence to DASH diet is effective in improving circulating serum inflammatory biomarkers in adults , compared with usual diet ; therefore , it could be a valuable strategy to suppress inflammation process
BACKGROUND & AIMS Dietary approaches to stop hypertension ( DASH ) diet is associated with improved blood pressure and risk of cardiovascular diseases .
It is proposed that DASH might also improve systemic inflammatory markers like highly sensitive C-reactive protein ( hs-CRP ) ; however , interventional studies have led to conflicting results .
The aim of current systematic review was to summarize results of r and omized clinical trials examining the effect of DASH on inflammatory biomarkers .
Inflammation Modifies the Effects of a Reduced-Fat Low-Cholesterol Diet on Lipids: Results From the DASH-Sodium Trial
Background —Inflammatory mediators regulate key aspects of lipid metabolism . We hypothesized that inflammation could diminish the cholesterol-lowering effect of a reduced-fat/low-cholesterol diet . Methods and Results —After a 2-week run-in period on a control diet ( 37 % total fat , 16 % saturated fat ) , 100 participants were r and omized to the control or DASH diet ( 27 % total fat , 6 % saturated fat ) for 12 weeks . Median C-reactive protein ( CRP ) at baseline was 2.37 mg/L ( interquartile range , 1.20 , 3.79 ) . The DASH diet , net of control , had no effect on CRP . Overall , there were significant net reductions in total ( −0.34 mmol/L ) , LDL ( −0.29 mmol/L ) , and HDL ( −0.12 mmol/L ) cholesterol from the DASH diet ( each , P < 0.001 ) and little change in triglycerides ( + 0.05 mmol/L , P = 0.21 ) . Baseline CRP was strongly associated with lipid responsiveness to the DASH diet . Total and LDL cholesterol were reduced to a greater degree in those with a “ low ” ( below median ) compared with a “ high ” ( above median ) baseline CRP ( total , −9.8 % versus −3 % ; P for interaction=0.006 ; LDL cholesterol , −11.8 % versus −3 % ; P for interaction=0.009 ) . Reductions in HDL cholesterol ( −8.8 % ) were similar in persons with low versus high CRP . Triglycerides were increased in those with a high CRP but not in those with a low CRP ( 19.8 % versus + 0 % ; P for interaction=0.019 ) . Conclusions —In this study , the presence of increased CRP was associated with less total and LDL cholesterol reduction and a greater increase in triglycerides from a reduced-fat/low-cholesterol diet . These findings document an additional mechanism by which inflammation might increase  cardiovascular disease risk
Adherence to DASH diet is effective in improving circulating serum inflammatory biomarkers in adults , compared with usual diet ; therefore , it could be a valuable strategy to suppress inflammation process
BACKGROUND & AIMS Dietary approaches to stop hypertension ( DASH ) diet is associated with improved blood pressure and risk of cardiovascular diseases .
It is proposed that DASH might also improve systemic inflammatory markers like highly sensitive C-reactive protein ( hs-CRP ) ; however , interventional studies have led to conflicting results .
The aim of current systematic review was to summarize results of r and omized clinical trials examining the effect of DASH on inflammatory biomarkers .