Vitamin D supplementation demonstrated a small but statistically significant improvement in ADHD total scores , inattention scores , hyperactivity scores , and behavior scores .
There was no statistically significant improvement in oppositional scores .
Reported adverse events in the vitamin D group were mild and not significantly different from the control group .
Vitamin D supplementation increased serum vitamin D levels and the ratio of patients with sufficient vitamin D levels .
Conclusions : Vitamin D supplementation as adjunctive therapy to methylpheni date appeared to reduce ADHD symptoms without serious adverse events , associated with improved vitamin D status .
Objective : A systematic review and meta- analysis of r and omized controlled trials ( RCTs ) were conducted to assess the benefits and harms of vitamin D supplementation for attention-deficit/hyperactivity disorder ( ADHD ) patients .
The Association of 25-Hydroxyvitamin D3 and D2 with Behavioural Problems in Childhood
Background Higher serum concentrations of 25-hydroxyvitamin D ( 25(OH)D ) , an indicator of vitamin D synthesis and intake , have been associated with better mental health and cognitive function . Concentrations of 1,25-dihydroxyvitamin D3 ( the active vitamin D3 metabolite ) have been associated with openness and extrovert behaviour , but 25(OH)D concentrations have not been associated with behavioural problems in humans . Methods We investigated the prospect i ve association between the different forms of 25(OH)D - 25(OH)D3 and 25(OH)D2–  and childhood behavioural problems in Avon Longitudinal Study of Parents and Children ( ALSPAC ) .  Serum 25(OH)D3 and 25(OH)D2 concentrations were assessed at mean age 9.9 years . Incident behavioural problems were assessed with Strengths and Difficulties Question naire ( SDQ ; emotional symptoms , conduct problems , hyperactivity-inattention problems , peer relationship problems and pro-social behaviour subscales and total difficulties score ) at mean age 11.7 . Sample sizes varied between 2413 - 2666 depending on the outcome . Results Higher 25(OH)D3 concentrations were weakly associated with lower risk of prosocial problems ( fully adjusted odds ratio : OR ( 95 % confidence interval : CI ) 0.85 ( 0.74 , 0.98 ) ) . Serum 25(OH)D3 or 25(OH)D2 concentrations were not associated with other subscales of SDQ or total difficulties score after adjusting for concfounders and other measured analytes related to vitamin D. Conclusions Our findings do not support the hypothesis that 25-hydroxyvitamin D status in childhood has important influences on behavioural traits in humans
Vitamin D supplementation demonstrated a small but statistically significant improvement in ADHD total scores , inattention scores , hyperactivity scores , and behavior scores .
There was no statistically significant improvement in oppositional scores .
Reported adverse events in the vitamin D group were mild and not significantly different from the control group .
Vitamin D supplementation increased serum vitamin D levels and the ratio of patients with sufficient vitamin D levels .
Conclusions : Vitamin D supplementation as adjunctive therapy to methylpheni date appeared to reduce ADHD symptoms without serious adverse events , associated with improved vitamin D status .
Objective : A systematic review and meta- analysis of r and omized controlled trials ( RCTs ) were conducted to assess the benefits and harms of vitamin D supplementation for attention-deficit/hyperactivity disorder ( ADHD ) patients .