The Camino Verde trial of community mobilisation for control of dengue reported a significant impact on entomological indices of the Aedes aegypti vector , and on serological dengue virus infection and self-reported dengue cases .
One reason for doing r and omised controlled trials ( RCTs ) is that experiments can be convincing .
Early epidemiological experimenters , such as Jenner and the smallpox vaccine and Snow and his famous Broad Street pump h and le , already knew the answer they were demonstrating ; they used the experiments as knowledge translation devices to convince others .
More sophisticated modern experiments include cluster r and omised controlled trials ( C RCTs ) for experiments in the public health setting .
Those who are convinced by a trial and want to act , need to know how the trial relates to their own context , what contributed to success , and what might make it even more effective .
Informed community mobilization for dengue prevention in households with and without a regular water supply: Secondary analysis from the Camino Verde trial in Nicaragua
Background Studies in different countries have identified irregular water supply as a risk factor for dengue virus transmission . In 2013 , Camino Verde , a cluster-r and omised controlled trial in Managua , Nicaragua , and Mexico ’s Guerrero State , demonstrated impact of evidence -based community mobilisation on recent dengue infection and entomological indexes of infestation by Aedes aegypti mosquitoes . This secondary analysis of data from the trial impact survey asks : ( 1 ) what is the importance of regular water supply in neighbourhoods with and without the trial intervention and ( 2 ) can community interventions like Camino Verde reasonably exclude households with adequate water supply ? Methods Entomological data collected in the dry season of 2013 in intervention and control communities allow contrasts between households with regular and irregular water supplies . Indicators of entomological risk included the House Index and pupa positive household index . Generalised linear mixed models with cluster as a r and om effect compared households with and without regular water , and households in intervention and control communities . Results For the House Index , regular water supply was associated with a protection in both intervention households ( OR 0.7 , 95%CI 0.6–0.9 ) and control households ( OR 0.6 , 95%CI 0.5–0.8 ) . For the pupa positive household index , we found a similar protection from regular water supply in intervention households ( OR 0.6 , 95%CI 0.4–0.8 ) and control households ( OR 0.7 , 95%CI 0.5–0.9 ) . The Camino Verde intervention had a similar impact on House Index in households with regular water supply ( OR 0.7 , 95%CI 0.5–1.0 ) and irregular water supply ( OR 0.6 , 95%CI 0.4–0.8 ) ; for the pupa positive household index , the effect of the intervention was very similar in households with regular ( OR0.5 , 95%CI 0.3–0.8 ) and irregular ( OR 0.5 , 95%CI 0.3–0.9 ) water supply . Conclusion While Aedes aegypti control efforts based on informed community mobilisation had a strong impact on households without a regular water supply , this intervention also impacted entomological indices in households with a regular water supply . These households should not be excluded from community mobilisation efforts to reduce the Aedes aegypti vector . Trial registration IS RCT N27581154
The Camino Verde trial of community mobilisation for control of dengue reported a significant impact on entomological indices of the Aedes aegypti vector , and on serological dengue virus infection and self-reported dengue cases .
One reason for doing r and omised controlled trials ( RCTs ) is that experiments can be convincing .
Early epidemiological experimenters , such as Jenner and the smallpox vaccine and Snow and his famous Broad Street pump h and le , already knew the answer they were demonstrating ; they used the experiments as knowledge translation devices to convince others .
More sophisticated modern experiments include cluster r and omised controlled trials ( C RCTs ) for experiments in the public health setting .
Those who are convinced by a trial and want to act , need to know how the trial relates to their own context , what contributed to success , and what might make it even more effective .