The effect of testosterone supplementation on BMD and the risk of falls or fracture remains inconclusive .
However , supplementation may benefit patients in the areas of sexual function and quality of life without increasing the risk of cardiovascular events , all-cause mortality , or prostatic events .
Testosterone deficiency ( TD ) may induce a series of clinical symptoms .
Studies have shown that testosterone supplementation may prevent these unfavourable symptoms and improve patients ’ quality of life .
Given the conflicting findings across studies , this systematic review aims to evaluate the effects and risks associated with testosterone supplementation in middle-aged or aging males with TD .
Effect of testosterone treatment on bone remodelling markers and mineral density in obese dieting men in a randomized clinical trial
To assess the effect of testosterone treatment on bone remodelling and density in dieting obese men , 100 obese men aged 53 years ( interquartile range 47–60 ) with a total testosterone level < 12 nmol/L receiving 10 weeks of a very low energy diet ( VLED ) followed by 46 weeks of weight maintenance were r and omly assigned at baseline to 56 weeks of intramuscular testosterone undecanoate ( n = 49 , cases ) or matching placebo ( n = 51 , controls ) . Pre-specified outcomes were between-group differences ( mean adjusted difference , MAD ) in serum c-telopeptide ( CTx ) , N-terminal propeptide of type 1 procollagen ( P1NP ) and bone mineral density ( BMD ) . At trial end , CTx was significantly reduced in men receiving testosterone compared to placebo , MAD −66 ng/L ( 95 % CI −113 , −18 ) , p = 0.018 , and this was apparent already after the 10 week VLED phase , MAD −63 ng/L ( 95 % CI −108 , −18 ) , p = 0.018 . P1NP was marginally increased after VLED , MAD + 4.2 ug/L ( 95 % CI −0.01 , + 8.4 ) , p = 0.05 but lower at study end , MAD −5.6 ug/L ( 95 % CI −10.1 , −1.1 ) , p = 0.03 . No significant changes in sclerostin , lumbar spine BMD or femoral BMD were seen . We conclude that in obese men with low testosterone levels  undergoing weight loss , bone remodelling markers are modulated in a way that may have favourable effects on bone mass
The effect of testosterone supplementation on BMD and the risk of falls or fracture remains inconclusive .
However , supplementation may benefit patients in the areas of sexual function and quality of life without increasing the risk of cardiovascular events , all-cause mortality , or prostatic events .
Testosterone deficiency ( TD ) may induce a series of clinical symptoms .
Studies have shown that testosterone supplementation may prevent these unfavourable symptoms and improve patients ’ quality of life .
Given the conflicting findings across studies , this systematic review aims to evaluate the effects and risks associated with testosterone supplementation in middle-aged or aging males with TD .