In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Herbal tea in the treatment of diabetes mellitus.
OBJECTIVE To evaluate the effects of a native herbal tea in patients with type 2 diabetes . DESIGN R and omized , placebo-controlled , single-blind study . SETTING The Metabolic Centre at the University of Alberta Hospitals . SUBJECTS Forty volunteers with type 2 diabetes . INTERVENTIONS After a 1 month " run-in " period , subjects drank 250 mL/d of either the herbal tea or a placebo tea for 10 days , and were followed up for a further 4 weeks . OUTCOME MEASURES A responder analysis defined as a 10 % change in mean blood glucose levels based on 4 capillary glucose readings daily . Secondary end points included changes in HbA1c , fructosamine and response to a meal challenge using Ensure . RESULTS The responder analysis showed no benefit from the herbal tea .  Fructosamine levels before and after tea therapy decreased significantly in both study groups . Mean HbA1c levels and incremental areas under the glucose curve ( AUC ) in the meal challenge did not change in either study group . These data were reanalysed in hyperglycemic subjects with HbA1c levels greater than 120 % of normal . The responder analysis and HbA1c levels did not change in either group . Mean ( and st and ard deviation ) fructosamine levels , before and after tea therapy , were significantly lower in the herbal tea group than in the placebo tea group ( 361 [ 98 ] versus 338 [ 100 ] micromol/L , p < 0.01 compared with 338 [ 60 ] versus 323 [ 49 ] micromol/L , p = 0.08 ) . In the hyperglycemic subgroup the mean AUC during the meal challenge , before versus after tea therapy , was 776 ( 369 ) versus 639 ( 331 ) mmol/L ( p = 0.22 ) in the herbal tea group and 433 ( 125 ) versus 420 ( 173 ) mmol/L ( p = 0.90 ) in the placebo group . CONCLUSIONS Although the responder analysis failed to show an effect of the herbal tea , the data suggest there may be a short-term benefit from the tea in subjects with poor glycemic control
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .