On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Levoamphetamine and dextroamphetamine: comparative efficacy in the hyperkinetic syndrome. Assessment by target symptoms.
In a nine-week double-blind crossover comparison of dextroamphetamine , levoamphetamine ( Cydril ) , and placebo with 11 hyperkinetic children , effects were assessed by an established teacher rating scale , a parent rating scale , and a new tool , weekly quantification of parent-selected target symptoms . Both active drugs were significantly more effective than placebo . Dextroamphetamine seemed consistently superior to levoamphetamine , though not to a significant degree ( on this size sample ) . Levoamphetamine seemed " slower starting , " requiring three weeks to show significant benefit on target symptoms , whereas dextroamphetamine showed nearly its maximum benefit the first week . Levoamphetamine seemed better for hyperactivity and aggressiveness than for inattentiveness , whereas dextroamphetamine seemed equally beneficial for all three . These data are consistent with the possibility that therapeutic effects of amphetamine on hyperkinetic children are mediated , at least in some , by dopaminergic systems
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .