However , mirtazapine showed effectiveness in treating depression , anxiety , sleep disorders , emesis and neuropathic pain .
Across all studies , mirtazapine is safe to use , with drowsiness and dizziness the most common side-effects .
Cancer patients often experience multiple distressing symptoms which are challenging to manage .
It would therefore be helpful to find a treatment that alleviates more than one symptom , to avoid polypharmacy : mirtazapine has been used in several studies for this purpose .
The objective of this study was to assess the effectiveness and safety of mirtazapine in alleviating one or more frequently encountered cancer-related symptoms .
Mirtazapine for chronic breathlessness? A review of mechanistic insights and therapeutic potential
ABSTRACT Introduction :  Chronic breathlessness  is a common and distressing symptom of advanced disease with few effective treatments . Central nervous system mechanisms are important in respiratory sensation and control . Consequently , drugs which may modify processing and perception of afferent information in the brain may have a role . Antidepressants have been proposed ; however , current evidence is limited . Of potentially suitable antidepressants , mirtazapine is an attractive option given its tolerability profile , low cost , and wide availability , along with additional potential benefits . Areas covered : The paper provides an overview of the physiology of breathlessness , with an emphasis on central mechanisms , particularly the role of fear circuits and the associated neurotransmitters . It provides a potential rationale for how mirtazapine may improve chronic breathlessness and quality of life in patients with advanced disease . The evidence was identified by a literature search performed in PubMed through to October 2018 . Expert opinion : Currently , there is insufficient evidence to support the routine use of antidepressants for chronic breathlessness in advanced disease . Mirtazapine is a promising c and i date to pursue , with definitive r and omized controlled trials required to determine its efficacy and safety in this setting
However , mirtazapine showed effectiveness in treating depression , anxiety , sleep disorders , emesis and neuropathic pain .
Across all studies , mirtazapine is safe to use , with drowsiness and dizziness the most common side-effects .
Cancer patients often experience multiple distressing symptoms which are challenging to manage .
It would therefore be helpful to find a treatment that alleviates more than one symptom , to avoid polypharmacy : mirtazapine has been used in several studies for this purpose .
The objective of this study was to assess the effectiveness and safety of mirtazapine in alleviating one or more frequently encountered cancer-related symptoms .