Outcomes , such as range of motion , recurrence , and clinical success , were frequently defined , however many different definitions were used .
This systematic review summarizes the outcome reporting st and ards in Dupuytren ’s disease treatment research .
Efficacy and safety of collagenase Clostridium histolyticum injection for Dupuytren contracture: report of 40 cases
Abstract Background Dupuytren ’s disease ( DD ) is a fibroproliferative pathology that affects the palmar aponeurosis causing the development of nodules and collagen cords and the progressive flexion of the fingers . The st and ard procedure is surgical fasciectomy , followed by high recurrence rates . Collagenase Clostridium histolyticum ( CCH ) injection represents an innovative noninvasive approach to the treatment of DD . This prospect i ve study was design ed to examine the efficacy and safety of CCH injection performed in the outpatient , using local anesthesia . Material s and methods Forty patients [ 32 metacarpophalangeal ( MP ) , 8 proximal interphalangeal ( PIP ) ] with Dupuytren ’s contracture of at least 20 ° for MP joint and any degree for PIP joint were included . The mean age was 66 . All joints were treated with a single vial of collagenase injection and manual breaking of the cord 24 h after . All adverse effects ( AEs ) were monitored . Patients were checked 7 , 30 , 90 , and 180 days after the injection . Primary endpoint was a reduction in digit contracture within 0 ° –5 ° of normal extension . Secondary endpoints were the improvement of range of motion , the evaluation of AEs incidence , and cost-effectiveness of collagenase treatment . Results About 67.5 % of patients obtained a clinical success . At 6 months , a further 7.5 % attained the same result . The mean contracture of treated joints was 5.3º for MP and 6.8 ° for PIP joints . Twenty-three patients had one or more mild-to-moderate side effects . Conclusions The use of collagenase appears to be an effective and safe method for the treatment of Dupuytren ’s contracture . Therapeutic success was achieved in a significant percentage of patients . The incidence of side effects was higher , but they were local reactions of short duration . The use of a single collagenase vial in patients treated in day surgery appears more cost-effective than surgery
Outcomes , such as range of motion , recurrence , and clinical success , were frequently defined , however many different definitions were used .
This systematic review summarizes the outcome reporting st and ards in Dupuytren ’s disease treatment research .