Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .
Challenges in the conduct of Thai herbal scientific study: efficacy and safety of phytoestrogen, pueraria mirifica (Kwao Keur Kao), phase I, in the alleviation of climacteric symptoms in perimenopausal women.
OBJECTIVE To evaluate the preliminary efficacy and safety of Pueraria mirifica ( Kwao Keur Kao ) , phytoestrogen , for the alleviation of climacteric symptoms . MATERIAL AND METHOD Perimenopausal women attending with climacteric symptoms , such as hot flushes and night sweats , were invited to join the present study , conducted at the Menopausal Clinic , Hat Yai Regional Hospital . The patients were voluntarily enrolled and r and omly received the raw material of Pueraria mirifica , oral 50 and 100 mg capsule , once daily for six months , as an open-label study . RESULTS Of the 10 enrolled patients , 8 cases were completely evaluated . The modified Greene climacteric scale ( MGCS ) was satisfactorily decreased in both groups . The average scale declined from 44.1 at baseline , to be 26 , 17 , and 11.1 at 1- , 3- , and 6- month follow-up respectively . No other laboratory abnormalities , except one case had transiently increased the creatinine level , and one case of increased blood urea nitrogen . The mean serum estradiol was slightly increased , while the mean serum follicle-stimulating hormone ( FSH ) and luteinizing hormone ( LH ) were nearly stable . CONCLUSION Pueraria mirifica is relatively safe and preliminarily alleviates the climacteric symptoms in perimenopausal . women , but the data is insufficient to draw definite conclusions regarding the estrogenic effect
Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .