These findings were robust in sensitivity analyses .
Conclusions This meta- analysis suggests that Mg supplementation significantly reduces serum CRP level .
Introduction The aim of the study was to undertake a systematic review and meta- analysis of prospect i ve studies to determine the effect of magnesium ( Mg ) supplementation on  C-reactive protein ( CRP ) .
Effect of Magnesium Supplementation on Carotid Intima-Media Thickness and Flow-Mediated Dilatation among Hemodialysis Patients: A Double-Blind, Randomized, Placebo-Controlled Trial
Objectives : The aim of the present study was to determine the efficacy of oral magnesium ( Mg ) supplementation on endothelial function through evaluation of carotid intima-media thickness ( cIMT ) , brachial artery flow-mediated dilatation ( FMD ) , and C-reactive protein ( CRP ) among hemodialysis ( HD ) patients . Methods : This r and omized , controlled , double-blind clinical trial consisted of 54 patients on HD . One group was treated orally with 440 mg of Mg oxide 3 times per week for 6 months ( n = 29 ) . The control group ( n = 25 ) was given placebo using the same administration protocol . cIMT , FMD , serum calcium levels , phosphorus , lipid , CRP , and bicarbonate were measured at baseline and at 6 months in both groups . Results : At 6 months , cIMT was significantly decreased in the Mg group ( 0.84 ± 0.13 mm at baseline and 0.76 ± 0.13 mm at 6 months , p = 0.001 ) . However , in the placebo group , cIMT was significantly increased ( 0.73 ± 0.13 and 0.79 ± 0.12 mm , respectively , p = 0.003 ) . When hypertension , diabetes mellitus , smoking , hyperlipidemia , and systemic lupus erythematosus were controlled for in the analysis , the effect of Mg remained significant in both groups ( p = 0.000 ) . Conclusion : Our results indicate that Mg might not improve endothelial function ( CRP level and FMD ) and that a decreased cIMT as a marker of atherosclerosis may be due to the inhibition of calcification through the regulation parathormone , calcium , and phosphorus
These findings were robust in sensitivity analyses .
Conclusions This meta- analysis suggests that Mg supplementation significantly reduces serum CRP level .
Introduction The aim of the study was to undertake a systematic review and meta- analysis of prospect i ve studies to determine the effect of magnesium ( Mg ) supplementation on  C-reactive protein ( CRP ) .