Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .
Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women.
CONTEXT Bicarbonate has been implicated in bone health in older subjects on acid-producing diets in short-term studies . OBJECTIVE The objective of this study was to determine the effects of potassium bicarbonate and its components on changes in bone resorption and calcium excretion over 3 months in older men and women . DESIGN , PARTICIPANTS , AND INTERVENTION In this double-blind , controlled trial , 171 men and women age 50 and older were r and omized to receive placebo or 67.5 mmol/d of potassium bicarbonate , sodium bicarbonate , or potassium chloride for 3 months . All subjects received calcium ( 600 mg of calcium as triphosphate ) and 525 IU of vitamin D(3 ) daily . MAIN OUTCOME MEASURES Twenty-four-hour urinary N-telopeptide and calcium were measured at entry and after 3 months . Changes in these measures were compared across treatment groups in the 162 participants included in the analyses . RESULTS Bicarbonate affected the study outcomes , whereas potassium did not ; the two bicarbonate groups and the two no bicarbonate groups were therefore combined . Subjects taking bicarbonate had significant reductions in urinary N-telopeptide and calcium excretion , when compared with subjects taking no bicarbonate ( both before and after adjustment for baseline laboratory value , sex , and changes in urinary sodium and potassium ; P = 0.001 for both , adjusted ) . Potassium supplementation did not significantly affect N-telopeptide or calcium excretion . CONCLUSIONS Bicarbonate , but not potassium , had a favorable effect on bone resorption and calcium excretion . This suggests that increasing the alkali content of the diet may attenuate bone loss in healthy older adults
Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .