Results Prophylactic antibiotics  prevent inflammatory complications after gynaecological surgery .
Prophylactic antibiotics are more effective in surgery requiring access to the peritoneal cavity or the vagina .
Cefotetan appears to be more capable in preventing the overall inflammatory complication rate than cefoxitin or cefazolin .
No benefit has been shown for the combination of antibiotics as prophylaxis .
No difference has been shown between the long-term and short-term use of antibiotics .
There is no need for the primary use of an anaerobic antibacterial agent .
Conclusion Antibiotics help to prevent postoperative inflammatory complications after major gynecologic surgeries
Purpose The aim of this study was to systematic ally review the literature on antibiotic prophylaxis in gynaecologic surgeries to prevent inflammatory complications after gynaecological operations .
Cefazolin is inferior to cefotetan as single-dose prophylaxis for women undergoing elective total abdominal hysterectomy.
The purpose of this prospect i ve , r and omized , double-blind clinical trial was to compare the efficacy of 1-g doses of intravenous cefazolin with that of 1-g doses of intravenous cefotetan in preventing major operative site infections after elective abdominal hysterectomy . A major operative site infection requiring parenteral antimicrobial therapy developed in 46 ( 9 % ) of 511 evaluable women : 30 ( 11.6 % ) of 258 women given cefazolin prophylaxis and 16 ( 6.3 % ) of 253 women given cefotetan prophylaxis ( relative risk , 1.84 ; 95 % confidence interval , 1.03 to 3.29 ; P < .05 ) . Risk factors for major operative site infection were younger age , lower postoperative hemoglobin concentration , and a proliferative endometrium . Ten ( 3.9 % ) of 258 women given cefazolin prophylaxis had a postoperative pelvic abscess ; two of these women required additional surgical procedures , compared with two ( 0.8 % ) of 253 women given cefotetan prophylaxis who had an abscess but did not require surgery ( relative risk , 4.9 ; 95 % confidence interval , 1.09 to 22.16 ; P = .04 ) . A greater number of infections and more serious infections occurred following cefazolin prophylaxis ; this treatment result ed in 234 additional hospital days for administration of parenteral antimicrobial therapy
Results Prophylactic antibiotics  prevent inflammatory complications after gynaecological surgery .
Prophylactic antibiotics are more effective in surgery requiring access to the peritoneal cavity or the vagina .
Cefotetan appears to be more capable in preventing the overall inflammatory complication rate than cefoxitin or cefazolin .
No benefit has been shown for the combination of antibiotics as prophylaxis .
No difference has been shown between the long-term and short-term use of antibiotics .
There is no need for the primary use of an anaerobic antibacterial agent .
Conclusion Antibiotics help to prevent postoperative inflammatory complications after major gynecologic surgeries
Purpose The aim of this study was to systematic ally review the literature on antibiotic prophylaxis in gynaecologic surgeries to prevent inflammatory complications after gynaecological operations .