During subgroup analysis , a more beneficial effect of magnesium supplementation was observed in diabetic subjects with hypomagnesaemia .
CONCLUSIONS Magnesium supplementation can produce a favourable effect on FPG , HDL , LDL , TG and SBP .
BACKGROUND Cardiovascular disorders remain the leading cause of death in type 2 diabetic patients .
In the present study , a systematic review and a meta- analysis of r and omised controlled trials ( RCTs ) were conducted aim ing to evaluate the effect of magnesium supplementation on  type 2 diabetes ( T2D ) associated cardiovascular risk factors in both diabetic and nondiabetic individuals .
Novel Risk Factors and the Prediction of Type 2 Diabetes in the Atherosclerosis Risk in Communities (ARIC) Study
OBJECTIVE The objective of this study was to determine potential added value of novel risk factors in predicting the development of  type 2 diabetes  beyond that provided by st and ard clinical risk factors . RESEARCH DESIGN AND METHODS The Atherosclerosis Risk in Communities ( ARIC ) Study is a population -based prospect i ve cohort study in four U.S. communities . Novel risk factors were either measured in the full cohort or in a case-control sample nested within the cohort . We started with a basic prediction model , previously vali date d in ARIC , and evaluated 35 novel risk factors by adding them independently to the basic model . The area under the curve ( AUC ) , net reclassification index ( NRI ) , and integrated discrimination index ( IDI ) were calculated to determine if each of the novel risk factors improved risk prediction . RESULTS There were 1,457 incident cases of diabetes with a mean of > 7.6 years of follow-up among 12,277 participants at risk . None of the novel risk factors significantly improved the AUC . Forced expiratory volume in 1 s was the only novel risk factor that result ed in a significant NRI ( 0.54 % ; 95 % CI : 0.33–0.86 % ) . Adiponectin , leptin , γ-glutamyl transferase , ferritin , intercellular adhesion molecule 1 , complement C3 , white blood cell count , albumin , activated partial thromboplastin time , factor VIII , magnesium , hip circumference , heart rate , and a genetic risk score each significantly improved the IDI , but net changes were small . CONCLUSIONS Evaluation of a large panel of novel risk factors for type 2 diabetes indicated only small improvements in risk prediction , which are unlikely to meaningfully alter clinical risk reclassification or discrimination strategies
During subgroup analysis , a more beneficial effect of magnesium supplementation was observed in diabetic subjects with hypomagnesaemia .
CONCLUSIONS Magnesium supplementation can produce a favourable effect on FPG , HDL , LDL , TG and SBP .
BACKGROUND Cardiovascular disorders remain the leading cause of death in type 2 diabetic patients .
In the present study , a systematic review and a meta- analysis of r and omised controlled trials ( RCTs ) were conducted aim ing to evaluate the effect of magnesium supplementation on  type 2 diabetes ( T2D ) associated cardiovascular risk factors in both diabetic and nondiabetic individuals .