Therefore , although the overall effect of metformin on the concentration of serum Hcy was neutral , our results suggested that metformin could increase the concentration of Hcy when exogenous B-group vitamins or folic acid supplementation was not given
The aim of this systematic review is to assess whether metformin could change the concentration of serum homocysteine ( Hcy ) with and without simultaneous supplementation of B-group vitamins or folic acid .
Does metformin decrease blood pressure in patients with Type 2 diabetes intensively treated with insulin?
AIMS We investigated in a double-blind study whether metformin reduces blood pressure ( BP ) in patients with Type 2 diabetes intensively treated with insulin . METHODS A total of 220 patients with Type 2 diabetes were asked to undergo 24-h ambulatory BP monitoring ( 24-h ABPM ) . One hundred and eighty-two gave informed consent . Eighty-nine were r and omized to metformin and 93 to placebo . Thirty-five subjects dropped out ( 13 placebo  , 22 metformin users ) ; 147 patients underwent a second  24-h ABPM , 16 weeks after r and omization . RESULTS Systolic BP ( SBP ) , diastolic BP ( DBP ) , pulse BP ( PP ) , mean BP ( MP ) and heart rate ( HR ) were measured as office BP measurements and as 24-h ABPM for 24-h , day and night . Office BP measurements did not differ significantly between the placebo- and metformin-treated groups for any BP measure , but showed a non-significant trend for SBP reduction with metformin use ( mean baseline-adjusted difference , metformin minus placebo : -4.2 mmHg , 95 % CI , -9.9 to + 1.5 ; P = 0.15 ) . The baseline-adjusted differences of the ambulatory measurements were -0.2 mmHg ( 95 % CI , -2.9 to + 2.6 ) for the 24-h SBP , and + 1.1 mmHg ( 95 % CI , -0.7 to + 2.8 ) for the 24-h DBP . On the whole , BP differences between metformin- and placebo-treated groups were not statistically significant . The only significant difference was for night-time PP ( baseline-adjusted difference : -2.2 mmHg ; 95 % CI , -4.2 to -0.2 ) . These results were not different after adjustment for age and diabetes duration , or for ( changes in ) body mass index , glycated haemoglobin , insulin dose or plasma homocysteine . CONCLUSION Metformin does not significantly affect BP in patients with Type 2 diabetes intensively treated with insulin
Therefore , although the overall effect of metformin on the concentration of serum Hcy was neutral , our results suggested that metformin could increase the concentration of Hcy when exogenous B-group vitamins or folic acid supplementation was not given
The aim of this systematic review is to assess whether metformin could change the concentration of serum homocysteine ( Hcy ) with and without simultaneous supplementation of B-group vitamins or folic acid .