Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .
The effects of vitamin D on severity of coronary artery atherosclerosis and lipid profile of cardiac patients
Introduction A deficiency of 25-hydroxyvitamin D ( 25(OH)D ) ( the st and ard biomarker for vitamin D status ) can have multiple impacts on the cardiovascular system . The aim of the study was to assess of the influence of 25(OH)D on severity of coronary atherosclerosis and lipid profile . Material and methods The study involved prospect ively 637 patients subject to coronary catheterization . The stage of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study score ( CASSS ) . Plasma concentration of 25(OH)D  was measured using an electrochemiluminescent immunoassay . The levels of total cholesterol ( TC ) , high-density cholesterol ( HDL-C ) and triglycerides ( TG ) were measured using the enzymatic method , and the concentration of low-density cholesterol ( LDL-C ) was calculated with the Friedewald equation . Results The average level of 25(OH)D was 15.85 ng/ml . A higher level of 25(OH)D was observed in men ( 16.28 ng/ml vs. 15.1 ng/ml ; p = 0.027 ) . The study did not reveal any significant correlation between the level of 25(OH)D and severity of coronary atherosclerosis . It was observed however that the increase of 25(OH)D level results in an increased number of patients without significant lesions in the coronary arteries . In the whole group of women and men in the age group of 70–80 years an inverse relationship was observed between the level of 25(OH ) and the severity of coronary atherosclerosis . The whole study group showed a statistically significant inverse correlation of the 25(OH)D level with TC ( p = 0.0057 ) , LDL-C ( p = 0.00037 ) and TG ( p = 0.00017 ) . Conclusions Women and men over 70 years showed an inverse correlation of the 25(OH)D level and the stage of coronary atherosclerosis . Deficiency of 25(OH)D affects the levels of TC , LDL-C and TG
Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .