There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants.
Animal and epidemiologic studies indicate that early nutrition has lasting effects on metabolism and cardiovascular disease risk . In adults , ( n-3 ) long-chain PUFA ( LCPUFA ) from fish oils improve blood pressure , the lipid profile , and possibly cardiovascular disease mortality . This r and omized trial is the first to investigate the effects of fish oil on blood pressure and the lipid profile in infancy . Healthy term 9-mo old infants ( n = 83 ) were r and omly assigned to 5 mL fish oil daily or no fish oil for 3 mo and to 2 different milk types . Before and after the intervention , blood pressure was measured with an oscillometric device , and blood was sample d for analysis of erythrocyte fatty acid composition and the plasma lipid profile . This paper examines the effects of the fish oil supplement , with adjustment for the effects of the milk intervention when relevant . The fish oil intervention increased erythrocyte ( n-3 ) LCPUFA content ( P < 0.001 ) . At 12 mo , infants administered fish oil had a lower systolic blood pressure [ adjusted mean difference ( 95 % CI ) ] 6.3 mm Hg ( 0.9 , 11.7 ) ( P = 0.02 ) , a 0.51 mmol/L ( 0.07 , 0.95 ) higher plasma total cholesterol ( P = 0.02 ) , and a 0.52 mmol/L ( 0.02,1.01 ) higher LDL cholesterol ( P = 0.04 ) than infants not administered fish oil . Plasma triacylglycerol was inversely associated with the erythrocyte content of eicosapentaenoic acid ( r = 0.34 , P < 0.01 ) , a biomarker of fish oil dose . The observed effects of fish oil are in accordance with findings in adults . The long-term health implication s warrant further investigation
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .