Results : Intentional factors affecting adherence include patient , caregiver and prescriber beliefs about therapies and the disease itself .
Conclusion : Due to the high level of caregiver involvement in the care of patients with AD , strategies that address caregiver concerns may improve adherence
Background / Aims : Treatment adherence is a major problem in numerous medical conditions , and is a particular challenge in patients with Alzheimer 's disease ( AD ) .
Alzheimer’s disease treatment: Assessing caregiver preferences for mode of treatment delivery
Introduction Management of patients with Alzheimer ’s Disease ( AD ) can exert a substantial burden upon caregivers . As new modes of treatment administration are developed , it is important to assess caregiver satisfaction and preference in a st and ardized manner . This study describes the development of the Alzheimer ’s Disease Caregiver Preference Question naire ( ADCPQ ) to assess AD caregivers ’ satisfaction with and preference for patch or capsule treatments in AD patients . Methods Twenty-five published articles ( 1987 - 2002 ) were review ed to identify potential ADCPQ domains . Three caregiver focus groups ( n=24 ) were conducted to develop a first draft of the question naire . After evaluating the acceptance of ADCPQ to caregivers through in-depth interviews ( n=10 ) , its psychometric properties were assessed using data from 986 patients enrolled in a multicenter , r and omized , double-blind , four-arm , placebo- and active-controlled , 24-week trial . Results Focus groups indicated that caregivers expressed dissatisfaction with current AD treatment routines including limitations related to : efficacy , administration schedule , number of pills , adherence to treatment , side effects , and taking pills . In-depth interviews with caregivers found the ADCPQ to be comprehensible with an acceptable layout . The result ant ADCPQ comprises three modules : A ) baseline , 11 items assessing treatment expectations ; B ) week 8 , 33 items on satisfaction and preferences with treatment options ; C ) week 24 , 10 items assessing overall opinions of treatment options . Missing data per item was low ( ≤0.3 % ) and domain internal consistency reliability was good ( 0.71–0.91 ) . Preference items were also valid when evaluating concordance and discordance between convenience and satisfaction patch and capsule domain scores . Conclusion AD treatment puts a significant strain on caregivers . New modes of treatment delivery may be less burdensome to caregivers , thereby increasing satisfaction and potential treatment adherence . The ADCPQ was well accepted by AD caregivers and its domains demonstrated satisfactory psychometric properties . The ADCPQ is a useful tool to underst and caregiver preferences for patch versus oral therapies in AD
Results : Intentional factors affecting adherence include patient , caregiver and prescriber beliefs about therapies and the disease itself .
Conclusion : Due to the high level of caregiver involvement in the care of patients with AD , strategies that address caregiver concerns may improve adherence
Background / Aims : Treatment adherence is a major problem in numerous medical conditions , and is a particular challenge in patients with Alzheimer 's disease ( AD ) .