This systematic review suggests that supplementation with phytonadione and menaquinone-4 reduces bone loss .
In the case of the latter , there is a strong effect on incident fractures among Japanese patients
BACKGROUND Observational and some experimental data suggest that low intake of vitamin K may be associated with an increased risk of fracture .
OBJECTIVE To assess whether oral vitamin K ( phytonadione and menaquinone ) supplementation can reduce  bone loss  and prevent fractures .
Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison with the effect of etidronate
Abstract . The purpose of the present study was to compare the effects of etidronate and menatetrenone on bone mineral density ( BMD ) and the incidence of vertebral fractures in postmenopausal women with osteoporosis . Seventy-two osteoporotic women , more than 5 years after menopause , 53–78 years of age , were r and omly divided into three administration groups : E group ; intermittent cyclical etidronate ( 200 mg/day , 14 days per 3 months ; n = 25 ) ; M group ; menatetrenone ( 45 mg/day , daily ; n = 23 ) ; and C group ( control ) ; calcium lactate ( 2 g/day , daily ; n = 24 ) . Forearm BMD was measured by dual-energy X-ray absorptiometry at 0 , 6 , 12 , 18 , and 24 months after the treatment started . There were no significant differences in age , body mass index , years since menopause , and initial BMD among the three groups . One-way analysis of variance ( ANOVA ) with repeated measurements showed a significant decrease in BMD in the C group ( P < 0.0001 ) . Two-way ANOVA with repeated measurements showed a significant increase in BMD in the M group compared with that in the C group ( P < 0.0001 ) , and a significant increase in BMD in the E group compared with that in the C and M groups ( P < 0.0001 and P < 0.01 , respectively ) . The indices of new vertebral fractures/1000 patient-years in the E and M groups were significantly higher than that in the C group ( χ2 = 47.7 ; P < 0.0001 and χ2 = 42.4 ; P < 0.0001 , respectively ) , and did not differ significantly between the E and M groups . The present preliminary study provides evidence to suggest that , despite the lower increase in BMD produced by me-natetrenone , this agent , as well as etidronate , may have the potential to reduce osteoporotic vertebral fractures in postmenopausal women with osteoporosis
This systematic review suggests that supplementation with phytonadione and menaquinone-4 reduces bone loss .
In the case of the latter , there is a strong effect on incident fractures among Japanese patients
BACKGROUND Observational and some experimental data suggest that low intake of vitamin K may be associated with an increased risk of fracture .
OBJECTIVE To assess whether oral vitamin K ( phytonadione and menaquinone ) supplementation can reduce  bone loss  and prevent fractures .