The hypercaloric fructose feeding trials found no significant overall mean arterial blood pressure effect of fructose in comparison with other carbohydrates .
Contrary to previous concerns , we found that isocaloric substitution of fructose for other carbohydrates did not adversely affect blood pressure in humans
Concerns have been raised about the adverse effect of  fructose  on blood pressure .
International dietary guidelines , however , have not addressed fructose intake directly .
A systematic review and meta- analysis was conducted to assess the effect of fructose in isocaloric exchange for other carbohydrates on  systolic , diastolic , and mean arterial blood pressures .
Fructose and vitamin C intake do not influence risk for developing hypertension.
Higher uric acid levels are associated with an increased risk for developing hypertension . Higher intake of fructose increases plasma uric acid levels and higher intake of vitamin C reduces uric acid levels , but whether these nutrients are independently associated with the risk for developing hypertension is unknown . We studied this question by analyzing data from participants of three large and independent prospect i ve cohorts : Nurses ' Health Study 1 ( n = 88,540 ) , Nurses ' Health Study 2 ( n = 97,315 ) , and the Health Professionals Follow-up Study ( n = 37,375 ) .  Relative risks and 95 % confidence intervals for incident hypertension were computed according to quintiles of fructose intake and categories of vitamin C intake using multivariable Cox proportional hazards regression . Fructose intake was not associated with the risk for developing hypertension ; the multivariable relative risks ( 95 % confidence intervals ) for the highest compared with the lowest quintile of fructose intake were 1.02 ( 0.99 to 1.06 ) in Nurses ' Health Study 1 , 1.03 ( 0.98 to 1.08 ) in Nurses ' Health Study 2 , and 0.99 ( 0.93 to 1.05 ) in Heath Professionals Follow-up Study . Regarding  vitamin C  , the relative risks for individuals who consumed > or = 1500 mg/d compared with those who consumed < 250 mg/d were 0.89 ( 0.83 to 0.96 ) in Nurses ' Health Study 1 , 1.02 ( 0.91 to 1.14 ) in Nurses ' Health Study 2 , and 1.06 ( 0.97 to 1.15 ) in Health Professionals Follow-up Study . In conclusion , fructose and vitamin C intake do not substantially influence the risk for developing hypertension
The hypercaloric fructose feeding trials found no significant overall mean arterial blood pressure effect of fructose in comparison with other carbohydrates .
Contrary to previous concerns , we found that isocaloric substitution of fructose for other carbohydrates did not adversely affect blood pressure in humans
Concerns have been raised about the adverse effect of  fructose  on blood pressure .
International dietary guidelines , however , have not addressed fructose intake directly .
A systematic review and meta- analysis was conducted to assess the effect of fructose in isocaloric exchange for other carbohydrates on  systolic , diastolic , and mean arterial blood pressures .