There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain .
Non-steroidal anti-inflammatory drugs ( NSAIDs ) are medications that are frequently used by athletes .
There may also be some abuse of these substances , although it is unclear whether NSAIDs in fact enhance performance .
We performed a systematic review and meta- analysis to evaluate the effect of NSAIDs on sport performance indices .
A Randomized Controlled Trial of the Effect of Naproxen on Delayed Onset Muscle Soreness and Muscle Strength
Objective To determine the effect of naproxen in attenuating the symptoms ( muscle soreness level ) and signs ( plasma creatine kinase [ CK ] activity and muscular strength decrement ) of delayed onset muscle soreness ( DOMS ) induced by repeated bouts of eccentric exercise . Design The design was a r and omized , double-blind , placebo-controlled , crossover trial with two testing phases of 8 days ' duration that were separated by a “ washout ” period of 7 days . Setting University-based sports science center . Participants Twenty healthy male volunteers who responded to a notice in the university 's athletic complex . Interventions Eccentric single-leg exercises were performed on days 1 , 3 , and 4 to induce DOMS in the quadriceps muscles . Naproxen or placebo tablets ( 500 mg ) were taken orally twice per day beginning on day 2 and continuing until the end of the testing phase . Main Outcome Measures Perception of muscle soreness and knee extensor torque were evaluated daily throughout each phase . Plasma CK levels were evaluated on days 1 , 3 , 6 , and 8 of each phase . Results After the eccentric exercise , plasma CK levels were similarly elevated in both naproxen and placebo conditions ( F = 1.42 ; p = 0.25 ) . After DOMS developed , naproxen reduced the perception of soreness on day 3 , when muscle soreness was highest ( F = 2.20 ; p = 0.04 ) . After treatments with naproxen , peak quadriceps torque during leg extension at 60 ° /s was higher than that after treatment with the placebo ( F = 4.77 ; p = 0.04 ) . There were no significant differences between the naproxen and placebo conditions for leg extension at 180 ° /s ( F = 1.66 ; p = 0.21 ) and 300 ° /s ( F = 0.71 ; p = 0.41 ) . Conclusion The data indicate that therapeutic doses of naproxen do not prevent CK release into the plasma but decrease the perception of muscle soreness and positively influence quadriceps peak torque
There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain .
Non-steroidal anti-inflammatory drugs ( NSAIDs ) are medications that are frequently used by athletes .
There may also be some abuse of these substances , although it is unclear whether NSAIDs in fact enhance performance .
We performed a systematic review and meta- analysis to evaluate the effect of NSAIDs on sport performance indices .