Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
The effect of high-dose vitamin D supplementation on serum vitamin D levels and milk calcium concentration in lactating women and their infants.
OBJECTIVE Improve vitamin D status in lactating women and their recipient infants , and measure breast milk calcium concentration [ Ca ] as a function of vitamin D regimen . DESIGN / METHODS Fully breastfeeding mothers were r and omized at 1 month postpartum to 2000 ( n = 12 ) or 4000 ( n = 13 ) IU/day vitamin D for 3 months to achieve optimal vitamin D status [ serum 25(OH)D > or = 32 ng/mL ( 80 nmol/L ) ] . Breast milk [ Ca ] , maternal and infant serum 25(OH)D and serum Ca , and maternal urinary Ca/Cr ratio were measured monthly . RESULTS Mothers were similar between groups for age , race , gestation , and birth weight . 25(OH)D increased from 1 to 4 months in both groups ( mean + /- SD ) : + 11.5 + /- 2.3 ng/mL for group 2000 ( p = 0.002 ) and + 14.4 + /- 3.0 ng/mL for group 4000 ( p = 0.0008 ) . The 4000 IU/day regimen was more effective in raising both maternal and infant serum levels and breast milk antirachitic activity than the 2000 IU/day regimen . Breast milk [ Ca ] fell with continued lactation through 4 months in the 2000 and 4000 IU groups . Decline in breast milk [ Ca ] was not associated with vitamin D dose ( p = 0.73 ) or maternal 25(OH)D ( p = 0.94 ) . No mother or infant experienced vitamin D-related adverse events , and all laboratory parameters remained in the normal range . CONCLUSION High-dose vitamin D was effective in increasing 25(OH)D levels in fully breastfeeding mothers to optimal levels without evidence of toxicity . Breast milk [ Ca ] and its decline in both groups during 1 to 4 months were independent of maternal vitamin D status and regimen . Both the mother and her infant attained improved vitamin D status and maintained normal [ Ca ]
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .