There was a significant heterogeneity for the impact of CLA  on CRP and IL-6 , but not TNF-α .
Conclusions This meta- analysis showed that CLA supplementation may increase inflammatory markers ( CRP and TNF-α ) .
Background / objectives Conjugated linoleic acid ( CLA ) is a polyunsaturated fatty acid with attractive biological activities .
Numerous studies have been conducted on the inflammation-lowering effects of CLA in in vitro and animal models .
However , the effects of CLA treatment on the inflammatory markers in humans are controversial .
Conjugated Linoleic Acid Impairs Endothelial Function
Objectives —To determine the effect of dietary supplementation with conjugated linoleic acid ( CLA ) on body mass index ( BMI ) , body fat distribution , endothelial function , and markers of cardiovascular risk . Methods and Results —Forty healthy volunteers with BMI > 27 kg/m2 were r and omized to receive a CLA isomeric mixture or olive oil in a 12-week double-blind study . Subcutaneous body fat and abdominal/hepatic fat content were assessed using skin-fold thicknesses and computed tomography scanning , respectively . Endothelial function was assessed by brachial artery flow-mediated dilatation ( FMD ) . Plasma isoprostanes were measured as an index of oxidative stress . CLA supplementation did not result in a significant change in BMI index or total body fat . There was a significant decrease in limb ( −7.8 mm , P<0.001 ) , but not torso skin-fold thicknesses or abdominal or liver fat content . Brachial artery FMD declined ( −1.3 % , P=0.013 ) , and plasma F2-isoprostanes increased ( + 91pg/mL , P=0.042 ) . Conclusions —A CLA isomeric mixture had at most modest effects on adiposity and worsened endothelial function . On the basis of these results , the use of the isomeric mixture of CLA as an aid to weight loss can not be recommended
There was a significant heterogeneity for the impact of CLA  on CRP and IL-6 , but not TNF-α .
Conclusions This meta- analysis showed that CLA supplementation may increase inflammatory markers ( CRP and TNF-α ) .
Background / objectives Conjugated linoleic acid ( CLA ) is a polyunsaturated fatty acid with attractive biological activities .
Numerous studies have been conducted on the inflammation-lowering effects of CLA in in vitro and animal models .
However , the effects of CLA treatment on the inflammatory markers in humans are controversial .