Once-daily dihydropyridine calcium channel blockers appeared to lower blood pressure by a relatively constant amount throughout the 24-hour dosing interval .
Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours .
BACKGROUND Calcium channel blockers are a heterogeneous class of drugs , including dihydropyridine and non-dihydropyridine subgroups , commonly used in the treatment of hypertension .
A systematic review of the 24-hour time course of the blood pressure-lowering effect has not been published .
OBJECTIVES To assess how much variation there is in hourly systolic and diastolic blood pressure lowering by dihydropyridine calcium channel blockers over a 24-hour period in people with hypertension aged 18 years or over , with baseline systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg , or both .
A double-blind evaluation of the effect of amlodipine on ambulatory blood pressure in hypertensive patients.
Amlodipine is a new long-acting calcium antagonist that has a long half-life and appears to be suitable for once-daily administration . A double-blind , r and omized , parallel , placebo-controlled study was conducted to evaluate the effect of amlodipine on ambulatory blood pressures in hypertensive patients . The study consisted of a 4-week single-blind placebo run-in phase , followed by 4 weeks of double-blind therapy . Ambulatory blood pressure was measured for 24 h at the end of the placebo run-in phase and after double-blind therapy . Sixteen patients were r and omized to receive either amlodipine 5 mg or placebo in a 2:1 ratio . Amlodipine 5 mg daily significantly reduced supine and st and ing blood pressure 24 h postdose . Ambulatory blood pressure recordings revealed adequate blood pressure control throughout the 24-h dosing interval . Amlodipine was well tolerated and only two patients reported side effects -- neither was withdrawn from therapy . No treatment-related abnormalities were noted . It was concluded that amlodipine 5 mg daily was effective antihypertensive therapy throughout the 24-h dosing period in the patients studied , and it was well tolerated
Once-daily dihydropyridine calcium channel blockers appeared to lower blood pressure by a relatively constant amount throughout the 24-hour dosing interval .
Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours .
BACKGROUND Calcium channel blockers are a heterogeneous class of drugs , including dihydropyridine and non-dihydropyridine subgroups , commonly used in the treatment of hypertension .
A systematic review of the 24-hour time course of the blood pressure-lowering effect has not been published .
OBJECTIVES To assess how much variation there is in hourly systolic and diastolic blood pressure lowering by dihydropyridine calcium channel blockers over a 24-hour period in people with hypertension aged 18 years or over , with baseline systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg , or both .