These studies demonstrated improvement in biochemical profiles , with a decline in or normalization of liver enzymes .
However , some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis .
There has been a growing interest in the role of vitamin E supplementation in the treatment and /or prevention of nonalcoholic fatty liver ( NAFLD ) .
Furthermore , histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only .
Vitamin E Treatment in Pediatric Obesity-Related Liver Disease: A Randomized Study
Objective A beneficial role of antioxidants in hepatopathic obese individuals has hitherto been inferred only from uncontrolled pilot studies . The authors compared the effect of vitamin E and weight loss on transaminase values and on ultrasonographic bright liver in a controlled group of children with obesity-related liver dysfunction . Methods Twenty-eight children with obesity-related hypertransaminasemia and bright liver were r and omly allocated to two single-blind groups : group 1 ( n = 14 ) treated with a low-calorie diet associated with oral placebo for 5 months , and group 2 ( n = 14 ) treated with a low-calorie diet associated with oral vitamin E ( 400 mg/d × 2 months , 100 mg/d × 3 months ) . Transaminase values and ultrasonographic liver brightness along with weight loss and vitamin E levels were monitored . Results Variations in transaminase levels and percentage of patients with normalized transaminase values were comparable in the two groups . The disappearance of bright liver was observed only in patients who lost weight and was twice as common in patients from group 1 . Two subgroups of patients with complete normalization of transaminase values emerged as a consequence of controlled adherence to diet alone ( n = 6 ; significant decrease of percent overweight : P = 0.0019 ) and to vitamin E alone ( n = 7 ; unmodified percent overweight and significant increase of vitamin E/cholesterol ratio : P < 0.0001 ) . Changes in treatment-induced alanine aminotransferase levels in these two subgroups were comparable at month 2 , whereas values at month 5 were significantly lower in the subgroup adherent to diet alone ( P = 0.04 ) . In the subgroup adherent to vitamin E alone , after 2 months washout , transaminase remained stable in 5 patients and increased in 2 ; bright liver persisted in all . Conclusions Oral vitamin E warrants consideration in obesity-related liver dysfunction for children unable to adhere to low-calorie diets
These studies demonstrated improvement in biochemical profiles , with a decline in or normalization of liver enzymes .
However , some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis .
There has been a growing interest in the role of vitamin E supplementation in the treatment and /or prevention of nonalcoholic fatty liver ( NAFLD ) .
Furthermore , histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only .