Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .
Changes in symptoms, lipid and hormone levels after the administration of a cream with phytoestrogens in the Climacteric--preliminary report.
OBJECTIVE To establish the changes in lipid and hormone levels , as well as in symptoms , after topical application of a cream with phytoestrogens in postmenopausal women . METHODS 30 postmenopausal women were studied . At baseline and 1 month after the beginning of treatment , levels of FSH , estradiol , estrone , testosterone , and rostenedione , dehydroepi and rosterone , total cholesterol , HDL-C , LDL-C , and triglycerides were measured . Climacteric symptoms were evaluated with a modified Kupperman 's index ( KI ) . The subjects received a cream with phytoestrogens ( n = 15 ) or placebo ( cold cream ) ( n = 15 ) in a r and omized , double-blind manner . Statistically significant differences were determined by Student 's t test . RESULTS No differences were found in hormones , lipids , or in KI between the groups . When comparing each group separately , only a significant decrease in KI was found , in both groups , at the end of the treatment . CONCLUSIONS This cream with phytoestrogens had an effect only in climacteric symptoms , but similar to the placebo . The lack of effect in the other variables was probably due to the administration route , or to a lack of effect of this product
Four trials that were not combined in meta-analyses suggested that extracts with high ( > 30 mg/d ) levels of genistein consistently reduced the frequency of hot flushes .
BACKGROUND Vasomotor symptoms , such as hot flushes and night sweats , are very common during the menopausal transition .
Hormone therapy has traditionally been used as a highly effective treatment , but concerns about increased risk of some chronic diseases have markedly increased the interest of women in alternative treatments .
Some of the most popular of these treatments are foods or supplements enriched with phytoestrogens-plant-derived chemicals that have estrogenic action .
OBJECTIVES To assess the efficacy , safety and acceptability of food products , extracts and dietary supplements containing high levels of phytoestrogens when compared with no treatment , placebo or hormone therapy for the amelioration of vasomotor menopausal symptoms ( such as hot flushes and night sweats ) in perimenopausal and postmenopausal women .