The findings support the effects of BAs on satiety , lipid and cholesterol metabolism , incretins and glucose homoeostasis , energy metabolism , gut microbiota and endoplasmic reticulum stress following bariatric surgery .
Many of these metabolic effects are modulated through the BA receptors FXR and TGR5 .
We also explore a possible link between BAs and carcinogenesis following bariatric surgery .
Conclusions : Overall there is good evidence to support the role of BAs in the metabolic effects of bariatric surgery through the above mechanisms .
BAs could serve as a novel therapeutic pharmacological target for the treatment of obesity and its associated co-morbidities
Background : Bariatric surgery is currently the most efficacious treatment for obesity and its associated metabolic co-morbidities , such as diabetes .
The metabolic improvements occur through both weight-dependent and weight-independent mechanisms .
Bile acids ( BAs ) have emerged as key signalling molecules that have a central role in modulating many of the physiological effects seen after bariatric surgery .
This systematic review assesses the evidence from both human and animal studies for the role of BAs in reducing the metabolic complications of obesity following bariatric surgery .
Lipid profile changes in patients undergoing bariatric surgery: a comparative study between sleeve gastrectomy and mini-gastric bypass.
OBJECTIVE To prospect ively evaluate the effect of different types of bariatric surgery on lipid profile . METHODS  Total cholesterol ( TC ) , High-Density-Lipoprotein cholesterol ( HDLc ) , Low-Density-Lipoprotein cholesterol ( LDLc ) and triglycerides ( TG ) levels  were evaluated before surgery and at 3 different post-operative time-points ( 3 , 6 and 12 months ) in consecutive obese subjects undergoing mini-gastric bypass ( MGB ) or sleeve gastrectomy ( SG ) . RESULTS At baseline , 74 MGB and 86 SG subjects were comparable for lipid profile and prevalence of hypercholesterolemia/hypertriglyceridemia . During the post-operative follow-up , both MGB and SG subjects showed significant changes in lipid profile . However , at 3 months , MGB patients showed higher changes in TC ( β = 0.179 , p = 0.022 ) and TG ( β = 0.265 , p = 0.001 ) than those undergoing SG . At 6-month post-operative follow-up , these differences were confirmed only for TC . After a 12-month follow-up , MGB and SG were entirely comparable for changes in lipid profile with the exception of HDLc , whose changes were higher in SG group ( β = 0.130 , p = 0.039 ) . Overall , the probability to normalize lipid profile during the 12-month follow-up was similar in MGB and in SG patients ( OR:1.24 , 95%CI:0.41 - 3.76 , p = 0.689 ) . CONCLUSION Despites some differences at 3 - 6 post-operative months , during a 12-month follow-up , SG and MGB showed a similar efficacy in the improvement of lipid profile of obese patients
The findings support the effects of BAs on satiety , lipid and cholesterol metabolism , incretins and glucose homoeostasis , energy metabolism , gut microbiota and endoplasmic reticulum stress following bariatric surgery .
Many of these metabolic effects are modulated through the BA receptors FXR and TGR5 .
We also explore a possible link between BAs and carcinogenesis following bariatric surgery .
Conclusions : Overall there is good evidence to support the role of BAs in the metabolic effects of bariatric surgery through the above mechanisms .
BAs could serve as a novel therapeutic pharmacological target for the treatment of obesity and its associated co-morbidities
Background : Bariatric surgery is currently the most efficacious treatment for obesity and its associated metabolic co-morbidities , such as diabetes .
The metabolic improvements occur through both weight-dependent and weight-independent mechanisms .
Bile acids ( BAs ) have emerged as key signalling molecules that have a central role in modulating many of the physiological effects seen after bariatric surgery .
This systematic review assesses the evidence from both human and animal studies for the role of BAs in reducing the metabolic complications of obesity following bariatric surgery .