Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effect of vitamin D supplementation, directly or via breast milk for term infants, on serum 25 hydroxyvitamin D and related biochemistry, and propensity to infection: a randomised placebo-controlled trial.
We assessed the effect of vitamin D supplementation on related biochemistry , infection and dentition of the infant . In a double-blind , placebo-controlled trial conducted in Lucknow , India ( latitude 26 ° N ) , 230 mother -newborn pairs were r and omised to receive , for 9 months , 3000µg/month oral vitamin D3 by the mother ( group A ) or 10µg/d by the infant ( group B ) or double placebo ( group C ) . All babies received 15 min of sun exposure ( unclothed ) during massage . Infants ' median 25-hydroxyvitamin D ( 25(OH)D ) was lower in group C ( median 45·3 ; interquartile range ( IQR ) 22 - 59·5 nmol/l ) than in groups A ( median 60·8 ; IQR 41·3 - 80·5 nmol/l ( P7.5µkat/l ) was significantly more frequent in group C babies ( 16 % ) than in group A ( 4 % ) or group B ( 0 % ) babies . The number of days with respiratory or diarrhoeal infection by 9 months of age was higher in group C ( median 46·5 ; IQR 14·8 - 73·3 d ) than in group A ( median 18·5 ; IQR 8·8 - 31·0 d ( P<0·01 ) ) or group B ( median 13·0 ; IQR 7·0 - 28·5 ( P<0·05 ) ) . We conclude that monthly maternal or daily infant supplementation with vitamin D along with sun exposure is superior to sun exposure alone in maintaining normal infant 25(OH)D at 3·5 months , and provide protection from elevated alkaline phosphatase and infectious morbidity
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .