Using mean data from the validation study , the trend and directionality in risk was similar in the Roux-en-Y group .
In conclusion , bariatric surgery predicts long-term decreases in CV risk in obese patients
Obese patients have an increased prevalence of  cardiovascular ( CV ) risk factors , which improve with bariatric surgery , but whether bariatric surgery reduces long-term CV events remains ill defined .
Validation of cardiovascular risk scores in a liver transplant population.
Increased prevalence of cardiovascular risk factors has been acknowledged in liver transplant recipients , and an increased incidence of cardiovascular events has been suspected . Individual risk determination , however , has not yet been established . Outpatient charts of 438 primary liver transplants have been review ed , and suspected cardiovascular risk factors were correlated with cardiovascular events observed during a follow-up period of 10 yr . Receiver operation characteristics curve ( ROC ) analysis was performed to vali date established cardiovascular risk scores . For calibration , the Hosmer-Lemeshow test was performed . A total of 303 of 438 patients were available for risk factor analysis at 6 months and demonstrated complete follow-up data ( 175 male , 128 female ) . A total of 40 of those 303 patients experienced fatal or nonfatal cardiovascular events ( 13.2 % ) . In univariate analysis , age ( P < 0.001 ) , gender ( P = 0.002 ) , body mass index ( P = 0.018 ) , cholesterol ( P = 0.044 ) , creatinine ( P = 0.006 ) , diabetes mellitus ( P = 0.017 ) , glucose ( 0.006 ) , and systolic blood pressure ( P = 0.043 ) , but not cyclosporine A ( P = 0.743 ) , tacrolimus ( P = 0.870 ) , or steroid medication ( P = 0.991 ) , were significantly associated with cardiovascular events . Multivariate analysis , however , identified only age , gender , and cholesterol as independent predictors . In ROC analysis , corresponding areas under the curve for Systematic Coronary Risk Evaluation Project ( SCORE ) , Prospect i ve Cardiovascular Münster Study ( PROCAM ) , and Framingham risk scores ( FRSs ) were calculated with 0.800 , 0.778 , and 0.707 , respectively . Calibration demonstrated an improved goodness of fit for PROCAM compared to SCORE risk calculations . In conclusion , SCORE and PROCAM proved to be valuable in discriminating our liver transplant recipients for their individual risk of cardiovascular events . Furthermore , calibrated PROCAM risk estimates are required to calculate the number of patients needed to treat in the setup of prospect i ve intervention trials
Using mean data from the validation study , the trend and directionality in risk was similar in the Roux-en-Y group .
In conclusion , bariatric surgery predicts long-term decreases in CV risk in obese patients
Obese patients have an increased prevalence of  cardiovascular ( CV ) risk factors , which improve with bariatric surgery , but whether bariatric surgery reduces long-term CV events remains ill defined .