All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .
Outcome of frail elderly patients with diffuse large B-cell lymphoma prospectively identified by Comprehensive Geriatric Assessment: results from a study of the Fondazione Italiana Linfomi
Abstract In 2003 the Fondazione Italiana Linfomi ( FIL ) started a clinical research program for investigating initial treatment of frail elderly patients with diffuse large B-cell lymphoma ( DLBCL ) identified by Comprehensive Geriatric Assessment ( CGA ) . From 2003 to 2006 , 334 elderly patients underwent CGA assessment , and 99 patients were classified as frail . Frail patients had a median age of 78 years , stage III – IV disease in 62 % and age-adjusted International Prognostic Index ( aaIPI ) of 2–3 in 53 % . Treatment consisted of several different regimens according to physician discretion . After a median follow-up of 36 months , 5-year overall survival ( OS ) was 28 % . In multivariate analysis , aaIPI 2–3 ( p = 0.005 ) and the presence of respiratory comorbidity ( p = 0.044 ) were the only factors that showed independent correlation with OS . Frail patients had a poorer outcome compared with fit patients also if they were treated with rituximab-containing combination chemotherapy ( hazard ratio 2.37 , 95 % confidence interval 1.48–3.78 ; p < 0.001 ) . CGA is a valid tool to prospect ively identify frail subjects among elderly patients with DLBCL
All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .