There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants
Several studies have reported that feeding γ-linolenic acid ( GLA ) has result ed in no increase in arachidonic acid ( AA ) in newborns . This result was ascribed to the eicosapentaenoic acid (EPA)-rich fish oil used in these formulas . Docosahexaenoic acid ( DHA ) sources with only minor amounts of EPA are now available , thus the addition of GLA to infant formulas might be considered an alternative to AA supplementation . Sixty-six premature infants were r and omized to feeding one of four formulas [ ST : no GLA , no long-chain polyunsaturated fatty acids ; BO : 0.6 % GLA ( borage oil ) ; BO + FOLOW : 0.6 % GLA , 0.3 % DHA , 0.06 % EPA ; BO + FOHIGH : 0.6 % GLA , 0.3 % DHA , 0.2 % EPA ] or human milk ( HM , nonr and omized ) for 4 wk . Anthropometric measures and blood sample s were obtained at study entry and after 14 and 28 d. There were no significant differences between groups in anthropometric measures , tocopherol , and retinol status at any of the studied time points . The AA content of plasma phospholipids was similar between groups at study start and decreased significantly until day 28 in all formulafed groups , but not in the breast-fed infants [ ST : 6.6±0.2 % , BO : 6.9±0.3 % , BO + FOLOW : 6.9±0.4 % , BO + FOHIGH : 6.7±0.2 % , HM : 8.6±0.5 % , where values are reported as mean ±st and ard error ; all formulas significantly different ( P≤0.05 ) from HM ] . There was no significant influence  of GLA or fish oil addition to the diet . GLA had only a very limited effect on AA status which was too small to obtain satisfactory concentrations ( concentrations similar to breast-fed babies ) under the circumstances tested . The effect of GLA on AA is independent of the EPA and DHA content in the diet within the dose ranges studied
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .