Conclusions Compared with high-dose statin therapy , ezetimibe with low-dose statin for more than 3 months may have a beneficial tendency of effects on glycemic control
Purpose Given the increased risk of incident diabetes and the side effects on glycemic control with statin treatment , statin and ezetimibe combination therapy has been widely used .
However , whether the same concern exists in ezetimibe remains uncertain .
This meta- analysis aim ed to investigate the influence of ezetimibe treatment on glycemic control .
Effect of Ezetimibe on Insulin Sensitivity and Lipid Profile in Obese and Dyslipidaemic Patients
Summary Aim : To evaluate the effect of ezetimibe on insulin sensitivity and lipid profile in obese and dyslipidaemic patients . Methods : A r and omized , double-blind , placebo-controlled clinical trial was carried out in 12 obese , dyslipidaemic patients , independently of their basal insulin sensitivity . At the beginning of the study , a metabolic profile was measured , and insulin sensitivity estimated using the euglycaemic-hyperinsulinaemic clamp technique . The volunteers were r and omly assigned to receive ezetimibe ( 10 mg/day in the morning ) or placebo for a period of 90 days . After intervention , a similar metabolic profile was measured and a second clamp study was performed . Results : Ezetimibe administration for 90 days decreased total ( 6.0 ± 0.5 vs. 4.2 ± 0.9 mmol/L , p = 0.011 ) and low-density lipoprotein ( 4.0 ± 0.7 vs. 2.2 ± 0.8 mmol/L , p=0.003 ) cholesterol concentrations without modification of insulin sensitivity ( 3.0 ± 0.6 vs. 2.9 ± 0.7 mg/kg/min , p = 0.345 ) . Conclusions : Ezetimibe significantly decreased total cholesterol and low-density lipoprotein cholesterol concentrations without affecting insulin sensitivity in obese and dyslipidaemic patients
Conclusions Compared with high-dose statin therapy , ezetimibe with low-dose statin for more than 3 months may have a beneficial tendency of effects on glycemic control
Purpose Given the increased risk of incident diabetes and the side effects on glycemic control with statin treatment , statin and ezetimibe combination therapy has been widely used .
However , whether the same concern exists in ezetimibe remains uncertain .
This meta- analysis aim ed to investigate the influence of ezetimibe treatment on glycemic control .