Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Supplementation with 1000 IU vitamin D/d leads to parathyroid hormone suppression, but not increased fractional calcium absorption, in 4-8-y-old children: a double-blind randomized controlled trial.
BACKGROUND The effects of vitamin D supplementation in healthy prepubertal children on physiologic outcomes have not been investigated . OBJECTIVE The objective was to evaluate the effects of supplementation with 1000 IU vitamin D(3)/d on calcium absorption . DESIGN In a double-blind , placebo-controlled trial , we r and omly assigned 64 children to 1000 IU vitamin D(3)/d ( n = 32 ) or placebo ( n = 32 ) for 8 wk . Stable isotopes were used to assess calcium absorption . The main outcome measure was calcium absorption before and after supplementation . RESULTS All of the data are shown as means ± SDs . At baseline , vitamin D intake was 221 ± 79 IU/d and calcium intake was 830 ± 197 mg/d . Baseline serum 25-hydroxyvitamin D [ 25(OH)D ] was not significantly correlated with fractional or total calcium absorption . After 8 wk , with baseline values used as a covariate , no differences were seen in fractional or total calcium absorption based on supplementation group ( P = 0.75 and 0.36 , respectively ) . Supplemented children had a significant increase in 25(OH)D concentrations ( from 27.7 ± 7.4 to 36.0 ± 10.3 ng/mL ; P < 0.0001 ) and a decrease in parathyroid hormone ( from 21.4 ± 10.4 to 12.9 ± 7.1 pg/mL ; P < 0.001 ) ; no significant changes in the placebo group were observed . No adverse side effects were noted in either group . CONCLUSIONS Vitamin D(3 ) supplementation at 1000 IU/d increases 25(OH)D and decreases parathyroid hormone in children with average vitamin D intakes below the dietary recommendations of the Institute of Medicine . However , no significant effects of this change on calcium absorption occurred . This trial was registered at clinical trials.gov as NCT 00868738
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .