In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Silymarin as an adjunct to glibenclamide therapy improves long-term and postprandial glycemic control and body mass index in type 2 diabetes.
Oxidative stress is increased postpr and ially and during long-term hyperglycemia in type 2 diabetic patients who present with poor response to glibenclamide . This study was design ed to evaluate the effects of the antioxidant flavonoid silymarin in improving long-term and postpr and ial glycemic and weight control in type 2 diabetic patients treated with glibenclamide .  Using a r and omized , double-blind , placebo-controlled design , 59 type 2 diabetic patients , previously maintained on 10 mg/day glibenclamide and diet control , with poor glycemic control , were r and omized into three groups : the first two groups were treated with either 200 mg/day silymarin or placebo as adjuncts to glibenclamide , and the third group was maintained on glibenclamide alone for 120 days . Fasting and 4-hour postpr and ial plasma glucose , glycated hemoglobin ( HbA(1c ) ) , and body mass index ( BMI ) were evaluated at baseline and after 120 days . Compared with placebo , silymarin treatment significantly reduced both fasting and postpr and ial plasma glucose excursions , in addition to significantly reducing HbA(1c ) levels and BMI after 120 days . No significantly different effects were observed for placebo compared to glibenclamide alone . In conclusion , adjunct use of silymarin with glibenclamide improves the glycemic control targeted by glibenclamide , during both fasting and postpr and ially , an effect that may be related to increased insulin sensitivity in peripheral tissues
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .