Results Prophylactic antibiotics  prevent inflammatory complications after gynaecological surgery .
Prophylactic antibiotics are more effective in surgery requiring access to the peritoneal cavity or the vagina .
Cefotetan appears to be more capable in preventing the overall inflammatory complication rate than cefoxitin or cefazolin .
No benefit has been shown for the combination of antibiotics as prophylaxis .
No difference has been shown between the long-term and short-term use of antibiotics .
There is no need for the primary use of an anaerobic antibacterial agent .
Conclusion Antibiotics help to prevent postoperative inflammatory complications after major gynecologic surgeries
Purpose The aim of this study was to systematic ally review the literature on antibiotic prophylaxis in gynaecologic surgeries to prevent inflammatory complications after gynaecological operations .
Preventing major operative site infection after radical abdominal hysterectomy and pelvic lymphadenectomy.
Twenty-one women who underwent radical abdominal hysterectomy and pelvic lymphadenectomy were enrolled in a prospect i ve , comparative , r and omized , placebo-controlled clinical trial of antimicrobial prophylaxis . Preoperative endocervical flora was identified and was similar in pre- and postmenopausal private and clinic service women ; 46 % of the 119 preoperative isolates produced beta-lactamase enzyme . Women were given three doses of either placebo or cefoperazone plus sulbactam , an irreversible beta-lactamase enzyme inhibitor . Three women ( 27 % ) given placebo developed abdominal incision infections ; one women given placebo also developed a pelvic infection . None given antibiotic developed operative site infection , but one women developed a drain site infection . A major operative site infection rate of 27 % observed with placebo is high enough to warrant prophylaxis . Although antimicrobial prophylaxis at radical hysterectomy and pelvic lymphadenectomy eradicted operative site infection in our patient population s , a literature review indicates that individual determination of a requirement for prophylaxis is necessary
Results Prophylactic antibiotics  prevent inflammatory complications after gynaecological surgery .
Prophylactic antibiotics are more effective in surgery requiring access to the peritoneal cavity or the vagina .
Cefotetan appears to be more capable in preventing the overall inflammatory complication rate than cefoxitin or cefazolin .
No benefit has been shown for the combination of antibiotics as prophylaxis .
No difference has been shown between the long-term and short-term use of antibiotics .
There is no need for the primary use of an anaerobic antibacterial agent .
Conclusion Antibiotics help to prevent postoperative inflammatory complications after major gynecologic surgeries
Purpose The aim of this study was to systematic ally review the literature on antibiotic prophylaxis in gynaecologic surgeries to prevent inflammatory complications after gynaecological operations .