The majority of the studies reported a high burden of work-related outcomes among inflammatory bowel disease patients regardless of the methodology used .
Inflammatory bowel disease patients experience a high burden in work-related outcomes .
BACKGROUND & AIMS Inflammatory bowel disease has considerable effects on work-related outcomes and leads to high societal costs due to sick leave and disability pension .
The aims of this study were to systematic ally review evidence on work-related outcomes that are relevant to productivity losses and to evaluate whether medical or surgical interventions have a positive impact on patients ' work ability .
Remission in Patients with Crohn's Disease is Associated with Improvement in Employment and Quality of Life and a Decrease in Hospitalizations and Surgeries
OBJECTIVES :  Hospitalization , surgery , work loss , and impaired quality of life contribute to the cost and burden of care for patients with Crohn 's disease . We examined the impact of remission on patients ' employment , quality of life , and hospitalization and  surgery  in a clinical trial to vali date clinical remission , as defined by the Crohn 's disease activity index ( CDAI ) , as the key treatment goal in managing Crohn 's disease . METHODS : ACCENT I evaluated the efficacy and safety of long-term dosing of infliximab compared to a single dose of infliximab in 573 patients with moderately-to-severely active Crohn 's disease . At wk 54 , employment status was compared between patients in CDAI remission and those not in CDAI remission , for those not employed at baseline . Physical component summary ( PCS ) and mental component summary ( MCS ) scores of the SF-36 question naire were also compared between these two groups . The numbers of Crohn's-related hospitalizations and surgeries were compared among four groups of patients who spent 0–25 % , 25–50 % , 50–75 % , and 75–100 % of time , respectively , in CDAI remission during the study . RESULTS : At baseline , patients had a severely impaired quality of life and a high unemployment rate ( 38.4 % ) . Among the group of patients who were unemployed at baseline , 31 % of those patients who achieved CDAI remission ( CDAI < 150 ) at wk 54 were employed , compared to 16 % who were not in CDAI remission at wk 54 ( p < 0.05 ) . PCS and MCS scores of patients in CDAI remission at wk 54 were significantly higher ( p < 0.0001 ) , indicating better mental and physical functioning , than those of patients not in CDAI remission at wk 54 , and were similar to those of the general U.S. population . Hospitalization and surgery rates decreased as the percentage of time patients were in CDAI remission increased ( p < 0.01 and p < 0.05 , respectively ) . CONCLUSIONS : CDAI remission is associated with reduced hospitalizations and surgeries , increased employment , and normalized quality of life . Sustained CDAI remission should be the key therapeutic goal in managing Crohn 's disease
The majority of the studies reported a high burden of work-related outcomes among inflammatory bowel disease patients regardless of the methodology used .
Inflammatory bowel disease patients experience a high burden in work-related outcomes .
BACKGROUND & AIMS Inflammatory bowel disease has considerable effects on work-related outcomes and leads to high societal costs due to sick leave and disability pension .
The aims of this study were to systematic ally review evidence on work-related outcomes that are relevant to productivity losses and to evaluate whether medical or surgical interventions have a positive impact on patients ' work ability .