No firm evidence was reached according to trial sequential analysis .
Conclusion There is insufficient data to recommend or refute the use of a specific material .
Coronal microleakage of two root-end filling materials using a polymicrobial marker.
The purpose of this study was to evaluate polymicrobial coronal leakage of mineral trioxide aggregate ( MTA ) and  amalgam . There were 108 single-rooted teeth r and omly divided into 3 groups of 32 teeth each and positive and negative control groups of 6 teeth and obturated with gutta percha and either Diaket ( 3M/ESPE , Seefeld , Germany ) , AH Plus ( Dentsply , De Trey , Konstanz , Germany ) , or Ketac Endo ( 3M/ESPE ) . These groups were further divided into 2 subgroups of 16 teeth in which root ends were resected and obturated with either MTA or zinc-free amalgam . The sample s have been incorporated in a dual-chamber leakage model with a polymicrobial marker of five facultative anaerobes on the coronal part . Leakage was observing during a period of 90 days . The least leakage was found in a combination of Diaket and MTA ( 76.9 + /-14.8 days ) followed by AH Plus and MTA ( 66.1 + /- 18.7 ) , Diaket and amalgam ( 60.0 + /- 23.1 ) , AH Plus and amalgam ( 56.9 + /- 22.1 ) , and Ketac Endo and MTA ( 42.1 + /- 17.8 ) , whereas the greatest leakage was observed in the Ketac Endo and amalgam group ( 40.0 + /- 17.24 ) . Sample s filled with MTA showed significantly better sealing than sample s filled with amalgam ( p < 0.05 )
No firm evidence was reached according to trial sequential analysis .
Conclusion There is insufficient data to recommend or refute the use of a specific material .