On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Methylphenidate vs dextroamphetamine vs caffeine in minimal brain dysfunction: controlled comparison by placebo washout design with Bayes' analysis.
Double-blind crossover comparison of methylpheni date hydrochloride , dextroamphetamine sulfate , and caffeine after placebo washout in 29 children with minimal brain dysfunction ( MBD ) showed on six ratings that methylpheni date and dextroamphetamine were significantly ( P less than .05 to P less than .001 ) better than placebo and caffeine , but not significantly ( P less than .05 ) different from each other . Placebo , caffeine , and ratings before drug did not differ significantly . Of 26 drug responders , 12 responded best to dextroamphetamine , ten to methylpheni date , and one to caffeine . The latter child showed no improvement at all with either prescription stimulant . Methylpheni date and dextroamphetamine were each efficacious for six children who did not respond to the other stimulant . All three drugs showed significant ( P less than .05 ) weight loss and cardiovascular side effects , the latter possibly spurious . Dextroamphetamine showed a significant ( P less than .05 ) decrease from placebo in " tummyaches .
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .