Results Insulin resistance indicators were significantly improved after bariatric surgery .
Leptin was also significantly decreased while adiponectin was significantly increased .
Although the level of metabolic hormones changed after bariatric surgery , they were not statistically significant .
Inflammation indicators were significantly decreased .
Significant reduction was also detected in PAI-1 and sICAM-1 .
Conclusions Bariatric surgery is beneficial in morbidly obese patients .
Although treating obesity in a surgical way may cause some complications , the weight loss is generally safe and effective
Background Considering conflicting results on the consequences of all types of obesity surgery , we were to summarize them via a systematic review .
Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions in Obese Women After Weight Loss Over One Year
Background —Visceral fat is a key regulator site for the process of inflammation , and atherosclerotic lesions are essentially an inflammatory response . Methods and Results —Fifty-six healthy premenopausal obese women ( age range 25 to 44 years , body mass index 37.2±2.2 , waist to hip ratio range 0.78 to 0.92 ) and 40 age-matched normal weight women were studied . Compared with nonobese women , obese women had increased basal concentrations of tumor necrosis factor-&agr ; ( TNF-&agr ; , P < 0.01 ) , interleukin-6 ( IL-6 , P < 0.01 ) , P-selectin ( P < 0.01 ) , intercellular adhesion molecule-1 ( ICAM-1 , P < 0.02 ) , and vascular adhesion molecule-1 ( VCAM-1 , P < 0.05 ) . Vascular responses to l-arginine ( 3 g IV ) , the natural precursor of nitric oxide , were impaired in obese women : reductions in mean blood pressure ( P < 0.02 ) , platelet aggregation to adenosine diphosphate ( P < 0.05 ) , and blood viscosity ( P < 0.05 ) were significantly lower as compared with those in the nonobese group . Concentrations of TNF-&agr ; and IL-6 were related ( P < 0.01 ) to visceral obesity , as well as to adhesin levels and responses to l-arginine . After 1 year of a multidisciplinary program of weight reduction ( diet , exercise , behavioral counseling ) , all obese women  lost at least 10 % of their original weight ( 9.8±1.5 kg , range 7.5 to 13 kg ) . Compared with baseline , sustained weight loss was associated with reduction of cytokine ( P < 0.01 ) and adhesin ( P < 0.02 ) concentrations and with improvement of vascular responses to l-arginine . Conclusion —In obese women , endothelial activation correlates with visceral body fat , possibly through inappropriate secretion of cytokines . Weight loss represents a safe method for downregulating the inflammatory state and ameliorating endothelial dysfunction in obese women
Results Insulin resistance indicators were significantly improved after bariatric surgery .
Leptin was also significantly decreased while adiponectin was significantly increased .
Although the level of metabolic hormones changed after bariatric surgery , they were not statistically significant .
Inflammation indicators were significantly decreased .
Significant reduction was also detected in PAI-1 and sICAM-1 .
Conclusions Bariatric surgery is beneficial in morbidly obese patients .
Although treating obesity in a surgical way may cause some complications , the weight loss is generally safe and effective
Background Considering conflicting results on the consequences of all types of obesity surgery , we were to summarize them via a systematic review .