Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effect of Cholecalciferol therapy on serum FGF23 in vitamin D deficient patients: a randomized clinical trial
Introduction Fibroblast growth factor-23 plays an important role in regulating systemic phosphate homeostasis , and vitamin D metabolism . However , the effect of Cholecalciferol therapy on FGF23 serum level in patients with vitamin D deficiency has not been studied , yet . Material s and methods This is a double-blind , r and omized clinical trial on 119 vitamin D deficient patients in 2016 . Biochemical variables of treatment and placebo groups were analyzed after 12 weeks of 50,000 IU of Cholecalciferol vs. placebo therapy once a week , by SPSS18 . Results After Cholecalciferol therapy , delta of serum PTH in treatment group was less than the controls ( P < 0.001 ) . However , delta values of serum 25(OH)D3 , 1,25(OH)2D3 and FGF23 in vitamin D treated group were more than the placebo-treated ones ( P < 0.001 , P = 0.002 , and P = 0.04 , respectively ) . Moreover , FGF23 serum level in treatment group was associated with serum calcium ( P = 0.005 , r = −0.256 ) , and serum 1,25(OH)2D3 ( P < 0.001 , r = 0.529 ) . Conclusions We propose that in these patients 1,25(OH)2D3 has a positive association with serum FGF23 , and hypostasized that serum calcium might be a down regulator of serum FGF23
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .