“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .
C-reactive protein (CRP) gene polymorphisms, CRP levels and risk of incident essential hypertension: findings from an observational cohort of Han Chinese
C-reactive  protein ( CRP ) , an acute phase reactant and marker of inflammation , has been shown to be associated with CRP genetic variants and incident hypertension , but it is unclear whether this link is causal . We therefore conducted a prospect i ve , nested case – control study to examine the relationship between single-nucleotide polymorphisms ( SNPs ) within the CRP gene , circulating CRP levels and the development of hypertension . Plasma CRP levels and the genotypes of eight SNPs were determined in 2000 unrelated Shanghai residents , including 908 hypertensive individuals and 1092 normotensive individuals . Among the 1092 normotensives , 968 subjects were followed up for 2 years , during which 71 developed hypertension . Plasma CRP levels were independently associated with the development of hypertension in the follow-up study ( odds ratio per quartile=1.64 ; 95 % confidence interval : 1.18–2.26 ; P<0.001 ) . The minor alleles of rs1130864 ( P<0.001 ) and rs3093059 ( P<0.001 ) were significantly associated with elevated CRP levels , and the minor alleles of rs1205 , rs1800947 and rs2246469 ( all P<0.001 ) were associated with decreased CRP levels . A haplotype-based analysis strengthened the results of single-locus analysis . However , none of the SNPs or haplotypes was significantly associated with blood pressure , incident hypertension or changes between baseline and follow-up blood pressure levels . Taken together , our findings demonstrated that plasma CRP levels were substantially associated with common genetic variants in the CRP gene and could predict the development of hypertension . However , the relationship between genotype and CRP levels was not associated with a change in hypertension risk
“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .