Conclusions : In summary , the use of ITF may have benefits for LDL-c reduction across all study population s , whereas HDL-c improvement and glucose control were demonstrated only in the T2DM subgroup .
Overall , ITF supplementation may provide a novel direction for improving the lipid profile and glucose metabolism
Long-term administration of inulin-type fructans has no significant lipid-lowering effect in normolipidemic humans.
Short-term studies have shown that the addition to diet of inulin-type fructans , a nondigestible carbohydrate , may have a plasma lipid-lowering effect in humans . Whether this beneficial effect persists during long-term administration has not been determined . The study was aim ed at determining whether a prolonged ( 6 months ) administration of inulin-type fructans to healthy subjects has a lipid-lowering action . In a double-blind , r and omized , placebo-controlled study , 17 healthy subjects were studied before and after 6 months of daily administration of placebo ( 8 subjects ) or 10 g of a mix of inulin and oligofructose ( 9 subjects ) . During this 6-month period , they consumed their usual diet and did not modify their everyday way of life . We measured plasma lipid concentrations ; cholesterol synthesis and hepatic lipogenesis ; and adipose tissue and circulating mononuclear cell messenger RNA concentrations of key regulatory genes of cholesterol metabolism . Compared with the administration of placebo , the administration of inulin-type fructans had no effect on plasma triacylglycerol concentrations and hepatic lipogenesis and induced only a nonsignificant trend for decreased plasma total and low-density lipoprotein cholesterol levels and increased high-density lipoprotein cholesterol concentration . Cholesterol synthesis was not significantly modified . Of all the messenger RNA concentrations measured , none was significantly modified by the administration of inulin-type fructans . In conclusion , contrary to what was observed in short-term studies , we observed no significant beneficial effect of a long-term ( 6-month ) administration of inulin-type fructans on plasma lipids in healthy human subjects
Conclusions : In summary , the use of ITF may have benefits for LDL-c reduction across all study population s , whereas HDL-c improvement and glucose control were demonstrated only in the T2DM subgroup .
Overall , ITF supplementation may provide a novel direction for improving the lipid profile and glucose metabolism