Conclusions Large r and omized controlled trials of at least 6 months duration with carbohydrate restriction appear superior in improving lipid markers when compared with low-fat diets .
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk .
Objective A systematic review and meta-analyses were conducted to compare the effects of very low , low , and moderate carbohydrate , higher fat diets versus high-carbohydrate , low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults .
Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men.
We tested whether nutrient intakes estimated from 4-d diet records were associated with plasma lipoprotein subclasses in 103 men who were r and omly assigned to a low-fat ( 24 % fat ) and a high-fat ( 46 % fat ) diet for 6 wk each in a crossover design . Postheparin plasma lipoprotein lipase ( LPL ) and hepatic lipase ( HL ) activities were also determined in a subset of 43 men . Changes in intake ( ie , high fat minus low fat ) of total saturated fatty acids , as well as myristic ( 14:0 ) and palmitic ( 16:0 ) acids , were positively correlated ( P < 0.01 ) with increases in mass of large LDL particles [ measured by analytic ultra-centrifugation as mass of lipoproteins of flotation rate ( Sf ) 7 - 12 ] and with LDL peak particle diameter and flotation rate , but not with changes in LDL-cholesterol concentration . Changes in total saturated fatty acids as well as myristic and palmitic acids were also inversely associated with changes in HL activity ( P < 0.05 ) . With the high-fat diet only , variation in dietary total saturated fatty acid intake was inversely correlated ( P < 0.01 ) with concentrations of small , dense LDL of Sf 0 - 5 . This correlation was significant specifically for myristic acid ( P < 0.001 ) . Stearic acid ( 18:0 ) , monounsaturates , and polyunsaturates showed no significant associations with lipoprotein concentrations . These data indicate that a high saturated fat intake ( especially 14:0 and 16:0 ) is associated with increased concentrations of larger , cholesterol-enriched LDL and this occurs in association with decreased HL activity
Conclusions Large r and omized controlled trials of at least 6 months duration with carbohydrate restriction appear superior in improving lipid markers when compared with low-fat diets .
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk .
Objective A systematic review and meta-analyses were conducted to compare the effects of very low , low , and moderate carbohydrate , higher fat diets versus high-carbohydrate , low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults .