Conclusion Based on available literature , evidence suggests that community-based interventions may reduce the incidence rate of T2DM and may positively affect anthropometric indices and HbA1C .
Due to the heterogeneity observed between trials we recommend more well- design ed RCTs with longer follow-up duration s be executed , to confirm whether community-based interventions lead to reduced T2DM events in the at-risk population of LMIC setting
Background The increasing prevalence of type 2 diabetes mellitus ( T2DM ) can have a substantial impact in low- and middle-income countries ( LMICs ) .
Community-based programs addressing diet , physical activity , and health behaviors have shown significant benefits on the prevention and management of T2DM , mainly in high-income countries .
However , their effects on preventing T2DM in the at-risk population of LMICs have not been thoroughly evaluated .
Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention and/or Pioglitazone in Reversion to Normal Glucose Tolerance in Prediabetes
Background . Patients with prediabetes are at high risk for diabetes and cardiovascular disease ( CVD ) . No study has explored whether intervention could revert prediabetes to normal glycemic status as the primary outcome . Beijing Prediabetes Reversion Program ( BPRP ) would evaluate whether intensive lifestyle modification and /or pioglitazone could revert prediabetic state to normoglycemia and improve the risk factors of CVD as well . Methods . BPRP is a r and omized , multicenter , 2 × 2 factorial design study . Participants diagnosed as prediabetes were r and omized into four groups ( conventional/intensive lifestyle intervention and 30 mg pioglitazone/placebo ) with a three-year follow-up . The primary endpoint was conversion into normal glucose tolerance . The trial would recruit 2000 participants ( 500 in each arm ) . Results . Between March 2007 and March 2011 , 1945 participants were r and omized . At baseline , the individuals were 53 ± 10 years old , with median BMI 26.0 ( 23.9 , 28.2 ) kg/m2 and HbA1c 5.8 ( 5.6 , 6.1)% . 85 % of the participants had IGT and 15 % had IFG . Parameters relevant to glucose , lipids , blood pressure , lifestyle , and other metabolic markers were similar between conventional and intensive lifestyle intervention group at baseline . Conclusion . BPRP was the first study to determine if lifestyle modification and /or pioglitazone could revert prediabetic state to normoglycemia in Chinese population . Major baseline parameters were balanced between two lifestyle intervention groups . This trial is registered with www.chictr.org.cn : ChiCTR-PRC-06000005
Conclusion Based on available literature , evidence suggests that community-based interventions may reduce the incidence rate of T2DM and may positively affect anthropometric indices and HbA1C .
Due to the heterogeneity observed between trials we recommend more well- design ed RCTs with longer follow-up duration s be executed , to confirm whether community-based interventions lead to reduced T2DM events in the at-risk population of LMIC setting
Background The increasing prevalence of type 2 diabetes mellitus ( T2DM ) can have a substantial impact in low- and middle-income countries ( LMICs ) .
Community-based programs addressing diet , physical activity , and health behaviors have shown significant benefits on the prevention and management of T2DM , mainly in high-income countries .
However , their effects on preventing T2DM in the at-risk population of LMICs have not been thoroughly evaluated .