There was no difference in mortality caused by NEC .
In premature newborns , the use of probiotics is effective as a prophylaxis for NEC and its complications
OBJECTIVE To eluci date the benefits of using probiotics in the prevention of  necrotizing enterocolitis ( NEC ) and its complications in preterm newborns .
Probiotics and Prebiotics for the Prevention of Necrotizing Enterocolitis
Necrotizing enterocolitis ( NEC ) continues to be a major cause of morbidity and mortality in premature infants . Although the pathogenesis of NEC remains unclear , abnormal bacterial colonization has been postulated as playing a central role . Various factors impact bacterial colonization following delivery . Compared to term infants , the bacterial colonization pattern in prematurely born infants is markedly different , with a greater predilection for colonization with pathogenic bacteria . Probiotic and prebiotic administration offers the opportunity to manipulate the intestinal bacterial environment , favoring the growth of commensal bacteria . Experimental data from animal studies and data from human trials suggest that probiotics decrease the incidence of NEC . These preliminary studies support the need for a large , r and omized , controlled trial to further investigate the role of probiotics in the prevention of NEC
There was no difference in mortality caused by NEC .
In premature newborns , the use of probiotics is effective as a prophylaxis for NEC and its complications
OBJECTIVE To eluci date the benefits of using probiotics in the prevention of  necrotizing enterocolitis ( NEC ) and its complications in preterm newborns .