The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
Efficacy of Listerine antiseptic in inhibiting the development of plaque and gingivitis.
A 9-month double-blind controlled clinical study was conducted on adult subjects using either Listerine antiseptic , its vehicle control  ,  or a water control in order to determine the efficacy of the antiseptic mouthrinse in inhibiting the development of plaque and gingivitis . Following screening examinations for minimal entry levels of plaque and gingivitis , all subjects received a complete prophylaxis . Subjects then continued their usual oral hygiene habits for a 3-week normalization period and were examined for soft tissue abnormalities and baseline measurements of plaque , gingivitis , and tooth stain . 2 additional prophylaxes were then performed , followed by a second baseline gingival examination . Zero plaque was re-established by rubber cup polishing and twice daily rinsing was begun . Soft tissue , plaque , gingivitis , and extrinsic tooth stain were evaluated after 1 , 3 , 6 and 9 months of rinsing with the r and omly assigned mouthrinses . Results demonstrated that Listerine antiseptic significantly reduced the development of plaque at 1 , 3 , 6 and 9 months and the development of gingivitis at 9 months , as compared to its vehicle control or water control
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .