No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .
Oral carnitine supplementation influences mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
Abstract Introduction : Limited data are available assessing the effects of oral carnitine supplementation on mental health parameters and biomarkers of oxidative stress of women with polycystic ovary syndrome (PCOS).This study was design ed to determine the effects of oral carnitine supplementation on mental health parameters and biomarkers of oxidative stress in women with PCOS . Methods : In the current r and omized , double-blind , placebo-controlled trial , 60 patients diagnosed with PCOS were r and omized to take either 250 mg carnitine supplements ( n = 30 ) or placebo ( n = 30 ) for 12 weeks . Results : After 12 weeks ’ intervention , compared with the placebo , carnitine supplementation result ed in a significant improvement in Beck Depression Inventory total score ( −2.7 ± 2.3 versus −0.2 ± 0.7 , p < 0.001 ) , General Health Question naire scores ( −6.9 ± 4.9 versus −0.9 ± 1.5 , p < 0.001 ) and Depression Anxiety and Stress Scale scores ( −8.7 ± 5.9 versus −1.2 ± 2.9 , p = 0.001 ) . In addition , changes in plasma total antioxidant capacity ( TAC ) ( + 84.1 ± 151.8 versus + 4.6 ± 64.5 mmol/L , p = 0.01 ) , malondialdehyde ( MDA ) ( −0.4 ± 1.0 versus + 0.5 ± 1.5 μmol/L , p = 0.01 ) and MDA/TAC ratio ( −0.0005 ± 0.0010 versus + 0.0006 ± 0.0019 , p = 0.003 ) in the supplemented group were significantly different from the changes in these indicators in the placebo group . Conclusions : Overall , our study demonstrated that carnitine supplementation for 12 weeks among patients with PCOS had favorable effects on parameters of mental health and biomarkers of oxidative stress
No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .