INTERPRETATION The guidelines have improved method ological reporting in RSA studies , but adherence to these guidelines is still relatively low .
BACKGROUND AND PURPOSE Guidelines for st and ardization of  radiostereometry ( RSA )  of implants were published in 2005 to facilitate comparison of outcomes between various research groups .
In this systematic review , we determined how well studies have adhered to these guidelines .
Local peroperative treatment with a bisphosphonate improves the fixation of total knee prostheses: A randomized, double-blind radiostereometric study of 50 patients
Background Postoperative migration of a joint prosthesis is related to the risk of late loosening . We have previously reported that oral treatment with clodronate reduced migration of the cemented NexGen total knee prosthesis during the first postoperative year , as measured by radiostereometry ( RSA ) . Oral bisphosphonate treatment is sometimes unpleasant , and local treatment will enable higher local concentrations . We now report the results of local peroperative treatment with another bisphosphonate , ib and ronate , with the same prosthesis . Methods This is a double-blind , r and omized study of 50 patients using RSA with maximal total point motion ( MTPM ) as primary effect variable . 1 mg ib and ronate ( 1 mL ) or 1 mL saline was applied to the tibial bone surface 1 min before cementation . RSA examination was done on the first postoperative day , and at 6 , 12 , and 24 months . Results One ib and ronate-treated patient died of unrelated causes , and 1 control patient refused to come for follow-up , leaving 24 patients in each group for analysis . There were no cases of aseptic loosening . By repeated measures ANOVA , migration ( MTPM ) was reduced by local application of ib and ronate ( p = 0.006 ) . The effect was most pronounced at 6 months , with a reduction from 0.45 to 0.32 mm ( 95 % CI for reduction : 0.04–0.21 mm ) . At 12 months , the migration from the postoperative examination was reduced from 0.47 to 0.36 mm ( 95 % CI for reduction : 0.02–0.20 mm ) . At 24 months , the reduction was from 0.47 to 0.40 mm ( 95 % CI : -0.01–0.16 mm ) . Interpretation This is the first study to show improvement of prosthesis fixation by local pharmacological treatment in humans . The treatment appears to be safe , cheap , and easy to perform . However , the improvement in postoperative stability was not greater than with systemic clodronate treatment
INTERPRETATION The guidelines have improved method ological reporting in RSA studies , but adherence to these guidelines is still relatively low .
BACKGROUND AND PURPOSE Guidelines for st and ardization of  radiostereometry ( RSA )  of implants were published in 2005 to facilitate comparison of outcomes between various research groups .
In this systematic review , we determined how well studies have adhered to these guidelines .