LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Continuation of statin treatment and all-cause mortality: a population-based cohort study.
BACKGROUND The beneficial effects of statins on cardiovascular mortality in secondary prevention have been established in several long-term , placebo-controlled trials . However , the value of statin therapy in reduction of overall mortality in patients without coronary heart disease ( CHD ) is question able . This study evaluated the effect of statin therapy in subjects with no indication of cardiovascular disease ( primary prevention ) and patients with known CHD ( secondary prevention ) . METHODS This retrospective cohort study included 229 918 adult enrollees in a health maintenance organization in Israel who initiated statin treatment from 1998 through 2006 ( mean age , 57.6 years ; 50.8 % female ) .  Proportion of days covered ( PDC ) with  statins  was measured by the number of dispensed  statin prescriptions during the interval between the date of the first statin prescription and the end of follow-up . RESULTS During a mean of 4.0 and 5.0 years of follow-up , there were 4259 and 8906 deaths among the primary prevention and secondary prevention cohorts , respectively . In both cohorts , continuity of treatment with statins ( PDC , > or = 90 % ) conferred at least a 45 % reduction in risk of death compared with patients with a PDC of less than 10 % . A stronger risk reduction was calculated among patients with high baseline low-density lipoprotein cholesterol level and patients initially treated with high-efficacy statins . CONCLUSIONS Better continuity of statin treatment provided an ongoing reduction in mortality among patients with and without a known history of CHD . The observed benefits from statins were greater than expected from r and omized clinical trials
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .