Enduring changes in personality/attitudes , depression , spirituality , anxiety , wellbeing , substance misuse , meditative practice s , and mindfulness were documented .
Mystical experiences , connectedness , emotional breakthrough , and increased neural entropy were related to these long-term changes in psychological functioning .
Finally , with proper screening , preparation , supervision , and integration , limited aversive side effects were noted by study participants .
Research into the basic effects and therapeutic applications of  psychedelic drugs  has grown considerably in recent years .
Yet , pressing questions remain regarding the substances ' lasting effects .
Although individual studies have begun monitoring sustained changes , no study to- date has synthesized this information .
Anxiety and depression in Nepal: prevalence, comorbidity and associations
Background Anxiety and depression are two important contributors to the global burden of disease . In many developing countries , including Nepal , their prevalences are yet to be assessed . Methods A nationwide cross-sectional study was conducted among a representative sample of Nepalese adults aged 18–65 years ( N = 2100 ) , selected by multistage r and om cluster sampling  and interviewed at home during unannounced visits . The vali date d question naires included the Hospital Anxiety and Depression Scale ( HADS ) , to detect cases of anxiety ( HADS-A ) , depression ( HADS-D ) and comorbid anxiety and depression ( HADS-cAD ) , the Eysenck Personality Question naire Revised Short Form-Neuroticism ( EPQRS-N ) , and the World Health Organization Quality of Life 8- question scale ( WHOQOL-8 ) . Logistic regression analyses were used to explore associations of caseness with four groups of variables : demographic , domicile , substance use , and behavioural and health . Results Age- and gender-adjusted point prevalences of HADS-A , HADS-D and HADS-cAD were 16.1 , 4.2 and 5.9 % respectively . In a multivariate model , HADS-A was positively associated with urban residence ( AOR = 1.82 ; p < 0.001 ) and neuroticism ( AOR = 1.32 ; p < 0.001 ) , and negatively with alcohol consumption ( AOR = 0.71 ; p = 0.041 ) . HADS-D was positively associated with marijuana use ( AOR = 3.61 ; p = 0.017 ) and negatively with quality of life ( QoL ) ( AOR = 0.86 ; p < 0.001 ) . HADS-cAD was positively associated with widowhood ( AOR = 2.71 ; p = 0.002 ) , urban residence ( AOR = 2.37 ; p = 0.001 ) , living at altitude ≥2000 m ( AOR = 2.32 ; p = 0.002 ) and neuroticism ( AOR = 1.26 ; p < 0.001 ) , and negatively with alcohol use ( AOR = 0.56 ; p = 0.026 ) and QoL ( AOR = 0.79 ; p < 0.001 ) . Conclusion Depression and anxiety are important mental health conditions in Nepal , and major contributors to public ill health , being very highly prevalent , comorbid and associated with psychosocial burden . They are also linked to the unique topography , habitation and social structure of the country . High prevalence coupled with the disabling nature of these disorders establishes their health-care priority and their importance in national health policy
Enduring changes in personality/attitudes , depression , spirituality , anxiety , wellbeing , substance misuse , meditative practice s , and mindfulness were documented .
Mystical experiences , connectedness , emotional breakthrough , and increased neural entropy were related to these long-term changes in psychological functioning .
Finally , with proper screening , preparation , supervision , and integration , limited aversive side effects were noted by study participants .
Research into the basic effects and therapeutic applications of  psychedelic drugs  has grown considerably in recent years .
Yet , pressing questions remain regarding the substances ' lasting effects .
Although individual studies have begun monitoring sustained changes , no study to- date has synthesized this information .