No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .
Effect of glycine propionyl-L-carnitine on aerobic and anaerobic exercise performance.
The purpose of this study was to evaluate the effect of glycine propionyl-L-carnitine ( GPLC ) supplementation and endurance training for 8 wk on aerobic- and anaerobic-exercise performance in healthy men and women ( age 18 - 44 yr ) . Participants were r and omly assigned to 1 of 3 groups : placebo ( n=9 ) , 1 g/d GPLC ( n=11 ) , or 3 g/d GPLC ( n=12 ) , in a double-blind fashion . Muscle carnitine ( vastus lateralis ) , VO(2peak ) , exercise time to fatigue , anaerobic threshold , anaerobic power , and total work were measured at baseline and after an 8-wk aerobic-training program . There were no statistical differences ( p > .05 ) between or within the 3 groups for any performance-related variable or muscle carnitine concentrations after 8 wk of supplementation and training . These results suggest that up to 3 g/d GPLC for 8 wk in conjunction with aerobic-exercise training is ineffective for increasing muscle carnitine content and has no significant effects on aerobic- or anaerobic-exercise performance
No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .