Insulin mediated inhibition of lipolysis was decreased in patients , reflected by increased non-esterified fatty acid levels .
Insulin resistance is a prominent feature of patients with type 1 diabetes mellitus and involves hepatic , peripheral and adipose tissues
OBJECTIVE The aim of this study was to perform a systematic review and meta- analysis on insulin resistance in adult patients with type 1 diabetes mellitus compared to healthy controls , assessed by hyperinsulinemic euglycemic clamp studies .
Insulin resistance-related factors, but not glycemia, predict coronary artery disease in type 1 diabetes: 10-year follow-up data from the Pittsburgh Epidemiology of Diabetes Complications Study.
OBJECTIVE To determine the independent risk factors for  coronary artery disease ( CAD )  in type 1 diabetes by type of CAD at first presentation . RESEARCH DESIGN AND METHODS This is a historical prospect i ve cohort study of 603 patients with type 1 diabetes diagnosed before 18 years of age between 1950 and 1980 . The mean age and duration of diabetes at baseline were 28 ( range 8 - 47 ) and 19 years ( 7 - 37 ) , respectively , and patients were followed for 10 years . Patients with prevalent CAD were excluded from the study .  Electrocardiogram ( ECG ) ischemia  was defined by Minnesota Code ( MC ) 1.3 , 4.1 - 3 , 5.1 - 3 , or 7.1 ; angina was determined by Pittsburgh Epidemiology of Diabetes Complications ( EDC ) study physician diagnosis ; and hard CAD was determined by angiographic stenosis > or = 50 % , revascularization procedure , Q waves ( MC 1.1 - 1.2 ) , nonfatal myocardial infa rct ion ( MI ) , or CAD death . RESULTS A total of 108 incident CAD events occurred during the 10-year follow-up : 17 cases of ECG ischemia , 49 cases of angina , and 42 cases of hard CAD ( 5 CAD deaths , 25 nonfatal MI or major Q waves , and 12 revascularization or > or = 50 % stenosis ) . Blood pressure , lipid levels , inflammatory markers , renal disease , and peripheral vascular disease showed a positive gradient across the groups of no CAD , angina , and hard CAD ( P < 0.01 , trend analysis , all variables ) , although estimated glucose disposal rate ( eGDR ) and physical activity showed inverse associations ( P < 0.01 , trend analysis , both variables ) . In addition , depressive symptomatology predicted angina ( P = 0.016 ) , whereas HbA(1 ) showed no association with subsequent CAD . CONCLUSIONS These data suggest that although the st and ard CAD risk factors are still operative in type 1 diabetes , greater glycemia does not seem to predict future CAD events . In addition , depressive symptomatology predicts angina and insulin resistance ( eGDR ) predicts hard CAD end points
Insulin mediated inhibition of lipolysis was decreased in patients , reflected by increased non-esterified fatty acid levels .
Insulin resistance is a prominent feature of patients with type 1 diabetes mellitus and involves hepatic , peripheral and adipose tissues
OBJECTIVE The aim of this study was to perform a systematic review and meta- analysis on insulin resistance in adult patients with type 1 diabetes mellitus compared to healthy controls , assessed by hyperinsulinemic euglycemic clamp studies .