The meta- analysis showed a significant increase in plasma adiponectin levels following statin therapy .
Although statins are known to increase the risk for new onset diabetes mellitus , our data might suggest that the mechanism for this is unlikely to be due to a reduction in adiponectin expression
BACKGROUND AND AIMS The effect of statin therapy on plasma adiponectin levels has not been conclusively studied .
Therefore , we aim ed to evaluate this effect through a systematic review and meta- analysis of available r and omized controlled trials ( RCTs ) .
Additive beneficial effects of atorvastatin combined with amlodipine in patients with mild-to-moderate hypertension.
BACKGROUND We hypothesized that atorvastatin combined with amlodipine has additive beneficial vascular and metabolic effects that are superior to monotherapy in patients with hypertension . METHODS Forty-two patients were given atorvastatin 20mg/day and placebo , atorvastatin 20mg/day and amlodipine 10mg/day , or amlodipine 10mg/day and placebo during each 2-month treatment period of a r and omized , single-blind , placebo-controlled cross-over trial with two 2-month washout periods . RESULTS Atorvastatin combined with amlodipine or amlodipine alone significantly reduced blood pressure to a greater extent than atorvastatin alone ( all P < 0.001 by ANOVA ) . Atorvastatin combined with amlodipine significantly reduced plasma malondialdehyde and improved flow-mediated dilation to a greater extent than atorvastatin or amlodipine alone ( all P < 0.001 by ANOVA ) . Atorvastatin therapy significantly increased insulin levels ( P = 0.004 ) and decreased plasma adiponectin levels ( P = 0.016 ) and insulin sensitivity ( determined by QUICKI ; P = 0.026 ) relative to baseline measurements . Amlodipine therapy significantly decreased insulin levels ( P = 0.001 ) and increased adiponectin levels ( P < 0.001 ) and insulin sensitivity ( P = 0.003 ) relative to baseline measurements . Atorvastatin combined with amlodipine therapy significantly increased adiponectin levels ( P < 0.001 ) and insulin sensitivity ( P = 0.034 ) relative to baseline measurements . Effects of all three therapeutic arms on adiponectin levels and insulin sensitivity were statistically significant ( P < 0.001 by ANOVA ) . CONCLUSIONS Atorvastatin combined with amlodipine therapy improves endothelial function and increases adiponectin levels and insulin sensitivity to a greater extent than monotherapy with either drug in hypertensive patients
The meta- analysis showed a significant increase in plasma adiponectin levels following statin therapy .
Although statins are known to increase the risk for new onset diabetes mellitus , our data might suggest that the mechanism for this is unlikely to be due to a reduction in adiponectin expression
BACKGROUND AND AIMS The effect of statin therapy on plasma adiponectin levels has not been conclusively studied .
Therefore , we aim ed to evaluate this effect through a systematic review and meta- analysis of available r and omized controlled trials ( RCTs ) .