In conclusion , preoperative exercise-based training improves pulmonary function before surgery and reduces in-hospital length of stay and postoperative complications after lung resection surgery for lung cancer
Lung cancer is the leading cause of cancer-related death worldwide .
For early stages of the disease , lung resection surgery remains the best treatment with curative intent , but significant morbidity is associated , especially among patients with poor pulmonary function and cardiorespiratory fitness .
In those cases , the implementation of a preoperative exercise-based intervention could optimize patient 's functional status before surgery and improve postoperative outcomes and enhance recovery .
The aim of this systematic review is to provide the current body of knowledge regarding the effectiveness of a preoperative exercise-based intervention on postoperative and functional outcomes in patients with lung cancer su bmi tted to lung resection surgery .
Effects of presurgical exercise training on systemic inflammatory markers among patients with malignant lung lesions.
Systemic inflammation plays an important role in the initiation , promotion , and progression of lung carcinogenesis . The effects of interventions to lower inflammation have not been explored . Accordingly , we conducted a pilot study to explore the effects of exercise training on changes in biomarkers of systemic inflammation among patients with malignant lung lesions . Using a single-group design , 12 patients with suspected operable lung cancer were provided with structured exercise training until surgical resection . Participants underwent cardiopulmonary exercise testing , 6 min walk testing , pulmonary function testing , and blood collection at baseline and immediately prior to surgical resection . Systemic inflammatory markers included intracellular adhesion molecule (ICAM)-1 , macrophage inflammatory protein-1alpha , interleukin (IL)-6 , IL-8 , monocyte chemotactic protein-1 , C-reactive protein , and tumor necrosis factor-alpha . The overall exercise adherence rate was 78 % , with patients completing a mean of 30 + /- 25 sessions . Mean peak oxygen consumption increased 2.9 mL.kg-1.min-1 from baseline to presurgery ( p = 0.016 ) . Results indicate that exercise training result ed in a significant reduction in ICAM-1 ( p = 0.041 ) . Changes in other inflammatory markers did not reach statistical significance . Change in cardiorespiratory fitness was not associated with change in systemic inflammatory markers . This exploratory study provides an initial step for future studies to eluci date the potential role of exercise , as well as identify the underlying mechanisms of action , as a means of modulating the relationship between inflammation and cancer pathogenesis
In conclusion , preoperative exercise-based training improves pulmonary function before surgery and reduces in-hospital length of stay and postoperative complications after lung resection surgery for lung cancer
Lung cancer is the leading cause of cancer-related death worldwide .
For early stages of the disease , lung resection surgery remains the best treatment with curative intent , but significant morbidity is associated , especially among patients with poor pulmonary function and cardiorespiratory fitness .
In those cases , the implementation of a preoperative exercise-based intervention could optimize patient 's functional status before surgery and improve postoperative outcomes and enhance recovery .
The aim of this systematic review is to provide the current body of knowledge regarding the effectiveness of a preoperative exercise-based intervention on postoperative and functional outcomes in patients with lung cancer su bmi tted to lung resection surgery .