In meta-regression , changes in plasma concentrations of adiponectin , leptin and CRP were associated with duration of treatment , but not with either change in BMI or baseline BMI values .
CONCLUSION Orlistat is effective in increasing plasma concentrations of adiponectin and decreasing those of leptin and CRP
AIMS To conduct a systematic review and meta- analysis of relevant r and omized clinical trials ( RCTs ) to ascertain the effect size of orlistat in modulating plasma levels of adipokines , ghrelin and C-reactive protein ( CRP ) .
Insulin and leptin concentrations in obese humans during long-term weight loss.
BACKGROUND Leptin is likely to be involved in the homeostasis of body weight . Insulin is suggested to regulate both short-term and long-term circulating leptin levels . The present study aims to assess the relation between insulin and leptin levels in obese humans . METHODS Some 53 obese subjects ( body mass index 35.1 + /- 3.9 kg m-2 ( mean + /- SD ) ) were prescribed a hypocaloric diet and r and omized to either a placebo or the intestinal lipase inhibitor orlistat for 2 years .  Serum leptin and insulin levels were determined repeatedly during these 2 years ( 5 times in the fasting condition and twice after an oral glucose load ) . RESULTS Leptin concentrations appeared to be regulated at a specific level for each individual throughout the weight-loss period . The BMI explained 39.7 % of the total variance in leptin levels , the body-fat distribution 17.2 % , individual characteristics 30.3 % ; and the fasting serum insulin concentration 1.0 % . After a mean weight loss of 7.7 + /- 4.9 kg , the time-integrated insulin response to an oral glucose load was significantly lower but the leptin response remained unchanged . CONCLUSIONS The BMI is the main determinant of the circulating leptin concentration in obese humans . Individual characteristics seem to determine the leptin level , given the BMI . In a short-term observational study in obese humans , changes of insulin levels do not appear to be correlated to changes in leptin levels
In meta-regression , changes in plasma concentrations of adiponectin , leptin and CRP were associated with duration of treatment , but not with either change in BMI or baseline BMI values .
CONCLUSION Orlistat is effective in increasing plasma concentrations of adiponectin and decreasing those of leptin and CRP
AIMS To conduct a systematic review and meta- analysis of relevant r and omized clinical trials ( RCTs ) to ascertain the effect size of orlistat in modulating plasma levels of adipokines , ghrelin and C-reactive protein ( CRP ) .