The literature on risk factors for cardiometabolic diseases showed that lutein might be beneficial for atherosclerosis and inflammatory markers , but there were inconsistent associations with blood pressure , adiposity , insulin resistance , and blood lipids .
CONCLUSIONS Our findings suggest that higher dietary intake and higher blood concentrations of lutein are generally associated with better cardiometabolic health .
BACKGROUND The antioxidant lutein is suggested as being beneficial to cardiometabolic health because of its protective effect against oxidative stress , but evidence has not systematic ally been evaluated .
OBJECTIVE We aim ed to evaluate systematic ally the effects of lutein ( intake or concentrations ) on cardiometabolic outcomes in different life stages .
Associations of serum carotenoid concentrations with the development of diabetes and with insulin concentration: interaction with smoking: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Smoking is associated with low serum carotenoid concentrations . Prospect i ve studies have found lower diabetes risk among persons with high-carotenoid diets . Whether diabetes risk is low in the rare smoker who has high serum carotenoid levels is unknown . The authors investigated the interaction of serum carotenoid concentrations and smoking with diabetes mellitus in 4,493 Black and White men and women aged 18 - 30 years in the Coronary Artery Risk Development in Young Adults ( CARDIA ) Study . The authors assessed 15-year ( 1985 - 2001 ) incident diabetes  ( 148 cases ) , insulin concentration , and insulin resistance  ( homeostasis model assessment ) in smokers and nonsmokers according to baseline levels of serum alpha-carotene , beta-carotene , zeaxanthin , beta-cryptoxanthin , and lycopene . Diabetes incidence was inversely associated with the sum of carotenoid concentrations in nonsmokers ( per st and ard deviation ( SD ) increase , relative hazard = 0.74 , 95 % confidence interval : 0.55 , 0.99 ) but not in current smokers ( relative hazard = 1.13 , 95 % confidence interval : 0.83 , 1.53 ) ( p for interaction = 0.02 ) . Similarly , year 15 insulin and insulin resistance values , adjusted for baseline levels , were inversely related to sum of carotenoids only in nonsmokers ( per SD increase in insulin level , slope = -0.46 ( p = 0.03 ) ; per SD increase in insulin resistance , slope = -0.14 ( p = 0.01 ) ) . In CARDIA , higher serum carotenoid concentrations are associated with lower risk of diabetes and insulin resistance in nonsmokers but not in smokers
The literature on risk factors for cardiometabolic diseases showed that lutein might be beneficial for atherosclerosis and inflammatory markers , but there were inconsistent associations with blood pressure , adiposity , insulin resistance , and blood lipids .
CONCLUSIONS Our findings suggest that higher dietary intake and higher blood concentrations of lutein are generally associated with better cardiometabolic health .
BACKGROUND The antioxidant lutein is suggested as being beneficial to cardiometabolic health because of its protective effect against oxidative stress , but evidence has not systematic ally been evaluated .
OBJECTIVE We aim ed to evaluate systematic ally the effects of lutein ( intake or concentrations ) on cardiometabolic outcomes in different life stages .