The present review demonstrates that vitamin D supplementation result ed in small but nonsignificant improvements in muscle strength compared to control in postmenopausal women .
No significant effect was observed in mobility after vitamin D administration
BACKGROUND The results obtained from previous trials regarding the effects of vitamin D supplementation on muscle strength and mobility  in postmenopausal women have been inconsistent .
This systematic review and meta- analysis of r and omised controlled trials ( RCTs ) aim ed to investigate the effect of vitamin D supplementation on muscle strength and mobility in postmenopausal women .
A randomized double-blinded placebo controlled trial of ergocalciferol 40,000 versus 100,000 IU per week for vitamin D inadequacy in institutionalized postmenopausal women
Background Vitamin D inadequacy is common in institutionalized post-menopausal women who are at the highest risk for osteoporotic fracture . Aim To evaluate efficacy and safety of ergocalciferol 40,000 versus 100,000 IU per week for 12 weeks for vitamin D inadequacy in institutionalized postmenopausal women . Method A r and omized double-blinded placebo-controlled trial was conducted in 94 institutionalized subjects with baseline 25(OH)D levels < 30 ng/mL. Subjects were r and omized to receive ergocalciferol 40,000 ( st and ard dose ) or ergocalciferol 100,000 IU ( high dose ) per week . Serum 25(OH)D levels , calcium , phosphate , h and grip strength , time up and go ( TUG ) test and quality of life by EQ-5D-5L were measured at baseline and 12 weeks after r and omization . Results Of the 94 subjects enrolled , 85 subjects completed the study . Subjects in the high dose group had higher mean 25(OH)D levels than subjects in the st and ard group ( 51.73 ± 19.35 and 34.5 ± 9.12 , p < 0.001 ) . More subjects in the high dose group ( 90.9 % ) achieved optimal 25(OH)D levels ( > 30 ng/mL ) than those in the st and ard group ( 65.9 % ) , p = 0.007 . In a subgroup analysis of subjects with vitamin D deficiency ( < 20 ng/mL , n = 44 ) and severe vitamin D deficiency ( < 10 ng/mL , n = 9 ) , more subjects in the high dose group achieved optimal 25(OH)D levels than those in the st and ard group ( 88 % and 100 % versus 47.4 % and 16.7 % with p of 0.007 and 0.018 , respectively ) . There were no differences in h and grip strength , TUG , EQ-5D-5L and adverse events between groups . Discussion / conclusions Subjects who received high dose ergocalciferol achieved more optimal 25(OH)D levels than those who received st and ard dose . High dose ergocalciferol is preferred to optimize 25(OH)D levels in subjects with severe vitamin D deficiency
The present review demonstrates that vitamin D supplementation result ed in small but nonsignificant improvements in muscle strength compared to control in postmenopausal women .
No significant effect was observed in mobility after vitamin D administration
BACKGROUND The results obtained from previous trials regarding the effects of vitamin D supplementation on muscle strength and mobility  in postmenopausal women have been inconsistent .
This systematic review and meta- analysis of r and omised controlled trials ( RCTs ) aim ed to investigate the effect of vitamin D supplementation on muscle strength and mobility in postmenopausal women .