The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .
Serum VEGF and b-FGF profiles after tension-free or conventional hernioplasty
Background Angiogenesis is strongly influenced by vascular endothelial growth factor ( VEGF ) and basic fibroblast growth factor ( b-FGF ) , whose production is also regulated by interferon (IFN)-γ and interleukin (IL)-10 . The aim of this study was to evaluate the modifications of serum VEGF , b-FGF , IFN-γ and IL-10 levels in patients with inguinal hernia undergoing hernioplasty with the Lichtenstein technique ( LH ) using polypropylene mesh or with Bassini open conventional inguinal hernia repair ( BH ) .  Material s and methods R and omly , 16 patients underwent BH , and 16 were treated with the LH technique using polypropylene mesh .  Blood sample s were collected 24 h prior to surgery and then 6 , 24 , 48 and 168 h postoperatively . The serum concentrations of VEGF , b-FGF , IFN-γ and IL-10 were evaluated . Results In BH patients , a peak of VEGF synthesis at 6 h with a normalization of this parameter 24 h after surgery has been observed . In the same subjects , b-FGF synthesis increased after surgery reaching significant levels 48 h later . On the contrary , in LH patients , a decrease in the serum VEGF and b-FGF concentrations was detected after surgery and their increase afterwards . IL-10 was increased in both groups 6 h after operation and declined to preoperative levels 24 h afterwards . IFN-γ enhanced in LH patients 6 h after surgery , whereas no modifications were detected in BH subjects . Conclusions This preliminary study shows that VEGF and b-FGF modifications , associated with alterations of cytokine secretion , are detectable in human undergoing hernioplasty , and suggests that they could somehow influence in the wound-healing process
The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .