Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Maintenance vitamin D3 dosage requirements in Chinese women with post menopausal osteoporosis living in the tropics.
BACKGROUND AND OBJECTIVES Vitamin D3 ( cholecalciferol ) dose required to maintain sufficiency in non- Caucasian women with postmenopausal osteoporosis ( PMO ) inthe tropics has not been well studied . Some guidelines m and ate 800 - 1000 IU vitamin D/day but the Endocrine Society ( US ) advocates 1500 - 2000 IU/day to maintain 25-hydroxyvitamin-D ( 25(OH)D ) concentration at > 75 nmol/L. We aim ed to establish oral cholecalciferol dose required to maintain 25(OH)D concentration at > 75 nmol/L in PMO Chinese Malaysian women , postulating lower dose requirements amongst light-skinned subjects in the tropics . METHODS AND STUDY DESIGN 90 Chinese Malaysian PMO women in Kuala Lumpur , Malaysia ( 2 ° 30'N ) with baseline serum 25(OH)D levels > = 50 nmol/L were recruited . Prior vitamin D supplements were discontinued and subjects r and omized to oral cholecalciferol 25,000 IU/4-weekly ( Group-A ) or 50,000 IU/4-weekly ( Group- B ) for 16 weeks , administered under direct observation . Serum 25(OH)D , PTH , serum/urinary calcium were measured at baseline , 8 and 16 weeks . RESULTS Baseline characteristics , including osteoporosis severity , sun exposure ( ~3 hours/week ) , and serum 25(OH)D did not differ between treatment arms . After 16 weeks , 91 % of women sufficient at baseline , remained sufficient on 25,000 IU/4-weekly compared with 97 % on 50,000 IU/4-weekly with mean serum 25(OH)D 108.1±20.4 and 114.7±18.4 SD nmol/L respectively ( p=0.273 ) . At trial 's end , 39 % and 80 % of insufficient women at baseline attained sufficiency in Group A and Group B ( p=0.057 ) . Neither dose was associated with hyperparathyroidism or toxicity . CONCLUSIONS Despite pretrial vitamin D supplementation and adequate sun exposure , 25.6 % Chinese Malaysian PMO women were vitamin D insufficient indicating sunshine alone can not ensure sufficiency in the tropics . Both ~900 IU/day and ~1800 IU/day cholecalciferol can safely maintain vitamin D sufficiency in > 90 % of Chinese Malaysian PMO women . Higher doses are required with baseline concentration < 75
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .