TRAb levels decreased at 6 but not 9 months .
At 6 months , patients on selenium supplementation were more likely than controls to show improved thyroid function ; however , the effect disappeared at 9 months .
Low selenium status is associated with increased risk of Graves ' disease ( GD ) .
While several trials have discussed the efficacy of selenium supplementation for thyroid function , in GD patients , the effectiveness of selenium intake as adjuvant therapy remains unclear .
In this systematic review and meta- analysis , we aim ed to determine the efficacy of selenium supplementation on thyroid function in GD patients .
Oxidation Products and Antioxidant Markers in Plasma of Patients with Graves' Disease and Toxic Multinodular Goiter: Effect of Methimazole Treatment
Oxidative stress plays an important role in hyperthyroidism-induced tissue damage , as well as in development of autoimmune disorders . To clarify influence of thyroid metabolic status and autoimmune factors on blood extracellular indices of reactive oxygen species ( ROS ) generation and free radical scavenging in hyperthyroidism , we studied patients with newly diagnosed and untreated Graves ' disease without infiltrative ophthalmopathy ( 17 female and 8 male , aged 41.8±8.9 ) and toxic multinodular goiter ( 15 female and 9 male , aged 48.4±10.1 ) under the same antithyroid treatment protocol .  Initially and after achievement of stable euthyroidism with methimazole  , plasma levels of hydrogen peroxide ( H2O2 ) , lipid hydroperoxides ( ROOH ) and ceruloplasmin ( CP ) and serum concentrations of thiobarbituric acid-reacting substances ( TBARS ) were determined . Similarly , activities of plasma superoxide dismutase ( SOD ) , catalase ( CAT ) , glutathione peroxidase ( GPx ) and glutathione reductase ( GR ) were assayed . The results were compared to those of age- and sex-matched controls . Average duration of hyperthyroidism and treatment period were similar in both patients groups . H2O2 , ROOH and TBARS concentrations were significantly higher in hyperthyroid patients compared to controls . Hyperthyroidism caused an evident increase in SOD and CAT activities and CP level , as well as a decrease in GPx and GR activities . Achievement of euthyroidism result ed in normalization of all analyzed parameters in both hyperthyroid patients groups . These findings suggest that the changes in blood extracellular indices of oxidative stress and free radical scavenging in hyperthyroid patients are influenced by thyroid metabolic status , and are not directly dependent on autoimmune factors present in Graves ' disease
TRAb levels decreased at 6 but not 9 months .
At 6 months , patients on selenium supplementation were more likely than controls to show improved thyroid function ; however , the effect disappeared at 9 months .
Low selenium status is associated with increased risk of Graves ' disease ( GD ) .
While several trials have discussed the efficacy of selenium supplementation for thyroid function , in GD patients , the effectiveness of selenium intake as adjuvant therapy remains unclear .
In this systematic review and meta- analysis , we aim ed to determine the efficacy of selenium supplementation on thyroid function in GD patients .