Dilated LA significantly increases the risk of AF recurrence after  single CPVI .
This is especially applicable to the patients with long-term follow-up
AIMS Left atrial ( LA ) enlargement is associated with atrial fibrillation ( AF ) .
However , it is controversial whether dilated atrium can predict post-ablation AF recurrence .
We undertook a systematic review and meta- analysis to analyse the association between LA diameter and  AF recurrence after single circumferential pulmonary vein isolation ( CPVI )  and explore the potential mechanism .
The impact of statins and renin-angiotensin-aldosterone system blockers on pulmonary vein antrum isolation outcomes in post-menopausal females.
AIMS To assess whether treatment with statins or renin-angiotensin-aldosterone system ( RAAS ) inhibitors as potential procedural ' augmenting agents ' improved  atrial fibrillation ( AF )  catheter ablation recurrence rates in post-menopausal females ( PMFS ) . METHODS AND RESULTS Five hundred and eighteen consecutive female patients had undergone AF catheter ablation from January 2005 to May 2008 . Post-menopausal females were selected and procedure outcomes were compared between cohorts of PMFS treated with statins or RAAS inhibitors to untreated PMFS . Out of 408 PMFS , 36 ( 8.8 % ) were treated with a combination of RAAS inhibitors and statins , thus were excluded leaving a total of 372 ( 91.2 % ) patients in the study . Out of 372 patients , 111 ( 29.8 % ) were on statins ( Group 1 ) , 59 ( 15.9 % ) on RAAS inhibitors ( Group 2 ) , and 202 ( 54.3 % ) without RAAS inhibitors or statins [ ( Group 3 ) control population ] . Over a mean follow-up time of 24 + /- 8.3 ( median 25 ) months , 78 ( 70.6 % ) in Group 1 , 38 ( 65.4 % ) in Group 2 , and 139 ( 68.8 % ) in Group 3 had procedural success . Statin or RAAS inhibitor use did not predict lower recurrence rates [ hazard ratio ( HR ) : 1.26 , P = 0.282 and HR : 1.14 , P = 0.728 , respectively ] . When compared with controls , no difference in the cumulative incidence of recurrence was found with statin or RAAS inhibitors use ( P = 0.385 and P = 0.761 , respectively ) . CONCLUSION Treatment with statins or RAAS inhibitors did not improve catheter ablation success rates among PMFS . Thereby , from a clinical st and point , PMFS should not be started on these treatments as a procedural ' augmenting agent ' at this time
Dilated LA significantly increases the risk of AF recurrence after  single CPVI .
This is especially applicable to the patients with long-term follow-up
AIMS Left atrial ( LA ) enlargement is associated with atrial fibrillation ( AF ) .
However , it is controversial whether dilated atrium can predict post-ablation AF recurrence .
We undertook a systematic review and meta- analysis to analyse the association between LA diameter and  AF recurrence after single circumferential pulmonary vein isolation ( CPVI )  and explore the potential mechanism .