In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Randomized and double-blinded pilot clinical study of the safety and anti-diabetic efficacy of the Rauvolfia-Citrus tea, as used in Nigerian traditional medicine.
AIM OF THE STUDY The aim of this r and omized and double blinded pilot clinical trial was to investigate the anti-diabetic efficacy of the Rauvolfia-Citrus ( RC ) tea in humans . We have earlier shown that a combination of calorie-restriction and chronic administration of the RC tea to the genetic diabetic ( BKS-db ) mice result ed in the normalization of blood sugar , reduction in lipid accumulated in the mice eyes and prevention of the degeneration of the otherwise brittle BKS-db pancreas . The tea is made by boiling foliage of Rauvolfia vomitoria and fruits of Citrus aurantium and is used to treat diabetes in Nigerian folk medicine . MATERIAL S AND METHODS The RC tea was produced using the Nigerian traditional recipe and tested in the traditional dosage on 23 Danish type 2 diabetes ( T2D ) patients . The participants were divided into two equivalent groups after stratification by sex , age and BMI , in a 4-month double-blinded , placebo-controlled and r and omized clinical trial . Most of the study subjects ( 19/23 ) were using oral anti-diabetic agents ( OADs ) . Mean disease duration was 6±4.6 years , mean age was 64±7 years and mean BMI was 28.7±3.8 kg/m(2 ) . Prior to starting the treatment , the participants received individual dietician consultations . RESULTS At the end of the 4-month treatment period , the treated group showed an 11 % decrease in 2-h postpr and ial plasma glucose relative to the 3 % increase in the placebo group ( p=0.004 ) . The improvement in blood glucose clearance with RC tea treatment was reflected in a 6 % reduction in HbA(1c ) ( p=0.02 ) and in a 10 % reduction in fasting plasma glucose ( p=0.02 ) , when comparing the post 4-month treatment to pre-treatment baseline values . Though the basal levels of phosphorylated acetyl CoA carboxylase enzyme in skeletal muscle were significantly reduced in the treated group ( p=0.04 ) , as compared to the placebo , only the pattern of reductions in the tissue fatty acids ( FAs ) differed in the two groups . While all types of FAs were reduced in placebo , only saturated ( SFA ) and monounsaturated ( MUFA ) FAs were reduced with treatment . Interestingly , a modest increase in the polyunsaturated FAs fraction was observed in the RC treated group . In addition , the reduction in SFA and MUFA with RC tea treatment came solely from the triglyceride fractions , as there was an increase in the skeletal muscle phospholipids . CONCLUSIONS Chronic administration of the RC tea to overweight T2D on OADs caused significant improvements in markers of glycaemic control and modifications to the fatty acid profile of skeletal muscle , without adverse effects or hypoglycaemia . Further exploration of the anti-diabetic effects of the RC tea is warranted
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .