The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels
Background A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D ( 25OHD ) levels on non-skeletal outcomes .
We performed a systematic quantitative review on characteristics of r and omized clinical trials ( RCTs ) included in meta-analyses ( MAs ) on non-skeletal effects of vitamin D supplementation .
Seasonal mood changes in 250 normal women
A 1-year prospect i ve study of seasonal mood changes was conducted in 250 female Boston area residents , aged 43 to 72 , who were participants in a study of vitamin D supplementation .  Each woman completed the Profile of Mood States question naire at four study visits . There were significant changes over the year in scores for Tension-Anxiety , Depression-Dejection , Anger-Hostility , Fatigue-Inertia , and Confusion-Bewilderment . These scores were all highest or " worst " in the fall and lowest in the spring or summer . Worse mood scores were associated with fewer hours of sleep . Serum thyroxine was positively associated with higher Depression-Dejection scores in August through November and with higher ( better ) Vigor-Activity scores in February through May. Supplementation with 400 IU of vitamin D did not appear to affect levels or changes in mood scores
The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels
Background A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D ( 25OHD ) levels on non-skeletal outcomes .
We performed a systematic quantitative review on characteristics of r and omized clinical trials ( RCTs ) included in meta-analyses ( MAs ) on non-skeletal effects of vitamin D supplementation .