There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .
A Randomized Controlled Trial of Intravenous or Oral Iron for Posttransplant Anemia in Kidney Transplantation
Background . Anemia after kidney transplantation has been associated with poor transplant outcomes . We hypothesized that intravenous ( IV ) iron may more rapidly correct anemia than oral ( PO ) iron . Methods . One hundred four kidney transplant recipients were prospect ively  r and omized to IV iron polymaltose ( 500 mg single dose ) or PO ferrous sulfate ( 210 mg elemental iron daily , continuously ) . The primary outcome was time to resolution of anemia , defined as hemoglobin more than or equal to 11 g/dL. Secondary outcomes included infections , blood transfusions , gastrointestinal side-effects , and acute rejection . Results . There was no significant difference in the primary outcome comparing IV with PO iron ( hazards ratio 1.22 ; 95 % confidence interval 0.82–1.83 ; P=0.32 ) . The median time to resolution of anemia was 12 days in the IV group versus 21 days in the PO group . There were no differences in infections ( 20 % vs. 24 % , P=0.62 ) , acute rejection ( 8 % vs. 6 % , P=0.68 ) , blood transfusions ( 10 % vs. 18 % , P=0.24 ) , and severe gastrointestinal side-effects ( 6 % vs. 12 % , P=0.29 ) between the IV iron and the PO iron groups . Conclusions . We conclude that a single dose of IV iron did not result in more rapid resolution of anemia compared with PO iron . Both IV and PO iron are safe and effective in the management of posttransplant anemia
There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .