The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .
Effect of losartan on ambulatory short-term blood pressure variability and cardiovascular remodeling in hypertensive patients on hemodialysis.
OBJECTIVE Previous studies have shown increases in ambulatory short-term blood pressure ( BP ) variability to be related to cardiovascular disease . In this study , we examined whether an angiotensin II type 1 receptor blocker losartan would improve ambulatory short-term BP variability in hypertensive patients on hemodialysis . METHODS Forty hypertensive patients on hemodialysis therapy were r and omly assigned to the losartan treatment group ( n=20 ) or the control treatment group ( n=20 ) . At baseline and 6 and 12 months after the treatment ,  24-h ambulatory BP monitoring  was performed .  Echocardiography  and  measurements of brachial-ankle pulse wave velocity ( baPWV ) and biochemical parameters were also performed before and after therapy . RESULTS After 6- and 12-months of treatment , nighttime short-term BP variability , assessed on the basis of the coefficient of variation of ambulatory BP , was significantly decreased in the losartan group , but remained unchanged in the control group . Compared with the control group , losartan significantly decreased left ventricular mass index ( LVMI ) , baPWV , and the plasma levels of brain natriuretic peptide and advanced glycation end products ( AGE ) . Furthermore , multiple regression analysis showed significant correlations between changes in LVMI and changes in nighttime short-term BP variability , as well as between changes in LVMI and changes in the plasma levels of AGE . CONCLUSION These results suggest that losartan is beneficial for the suppression of pathological cardiovascular remodeling though its inhibitory effect on ambulatory short-term BP variability during nighttime
The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .