Conclusion This study suggests that the probiotics supplementation could potentially reduce the weight gain and improve some of the associated metabolic parameters , which may become an effective strategy for the prevention and treatment of obesity in adult individuals
Background The prevalence of overweight/obesity in adults is raised to 39 % , which is nearly tripled more than 1975 .
The alteration of the gut microbiome has been widely accepted as one of the main causal factors .
To find an effective strategy for the prevention and treatment of overweight/obesity , a systematic review and meta- analysis were design ed .
Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease ( CVD ) . Circulating succinate , a metabolite produced by both microbiota and the host , is increased in hypertension , ischemic heart disease , and type 2 diabetes . We aim ed to analyze systemic levels of succinate in obesity , a major risk factor for CVD , and its relationship with gut microbiome . We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospect i ve cohorts of Caucasian Spanish subjects . Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism . This increase was associated with specific changes in gut microbiota related to succinate metabolism : a higher relative abundance of succinate-producing Prevotellaceae ( P ) and Veillonellaceae ( V ) , and a lower relative abundance of succinate-consuming Odoribacteraceae ( O ) and Clostridaceae ( C ) in obese individuals , with the ( P + V/O + C ) ratio being a main determinant of plasma succinate .  Weight loss  intervention decreased ( P + V/O + C ) ratio coincident with the reduction in circulating succinate . In the spontaneous evolution after good dietary advice , alterations in circulating succinate levels were linked to specific metagenomic signatures associated with carbohydrate metabolism and energy production with independence of body weight change . Our data support the importance of microbe – microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk
Conclusion This study suggests that the probiotics supplementation could potentially reduce the weight gain and improve some of the associated metabolic parameters , which may become an effective strategy for the prevention and treatment of obesity in adult individuals
Background The prevalence of overweight/obesity in adults is raised to 39 % , which is nearly tripled more than 1975 .
The alteration of the gut microbiome has been widely accepted as one of the main causal factors .
To find an effective strategy for the prevention and treatment of overweight/obesity , a systematic review and meta- analysis were design ed .