Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .
Effect of intralesional verapamil for treatment of Peyronie’s disease: a randomized single-blind, placebo-controlled study
Purpose We aim ed to assess the effect of intralesional verapamil on the treatment of Peyronie ’s disease . Material s and methods This r and omized study involved 80 patients . First , they were divided into two groups . The first group ( case : 40 patients ) received intralesional verapamil and the second group ( control : 40 patients ) local saline injection . They were followed about 24 weeks and evaluated for the size of plaques , plaque softening , reduction of pain and amelioration of penile deformity and erectile dysfunction ( estimated by the International Index of Erectile Function ) before and after treatment . Results Reduction of plaque size was seen in 17.5 % of the case group and 12.8 % of the control group ( P : 0.755 ) . Pain was reduced in 30 % of the case group and 28.2 % of the control group ( P : 0.99 ) . Curvature was decreased in 17.5 % of the case group and 23.1 % the control group ( P : 0.586 ) . Plaque softening was seen in 30 % of the case group compared with 25.6 % improvement in the control group ( P : 0.803).Also we found 5 % and 2.6 % improvement in sexual dysfunction in the case and control groups , respectively . ( P : 0.985 ) . Conclusion Although in some studies verapamil has been found to be effective in the treatment of Peyronie ’s disease , we did not find any improvement in comparison with the control group . Furthermore , larger scale studies are warranted to assess the effect of this drug on the treatment of Peyronie ’s disease
Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .