Although this study did not consider placebo effect and has high IPSS baseline scores , this study clarifies that low-dose tamsulosin has generally positive effect and safety in treatment of LUTS and could be a suitable option as an initial treatment , especially for patients with low body mass index , as is typical of Asian people
PURPOSE In Asian countries , low-dose tamsulosin ( 0.2 mg ) is used widely but this dose has been less popular than 0.4 mg tamsulosin or other types of alpha blockers .
The aim of this study was to investigate the efficacy and safety of low-dose tamsulosin by systematic review and meta- analysis .
Effect of doxazosin gastrointestinal therapeutic system 4 mg vs tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms: a prospective, multicenter, randomized, open, parallel study.
OBJECTIVE To compare the efficacy of the doxazosin gastrointestinal therapeutic system ( doxazosin-GITS ) 4 mg and tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms ( LUTS ) suggestive of benign prostatic hyperplasia ( BPH ) . METHODS Data were analyzed from a prospect i ve , multicenter , r and omized , open , parallel study of Chinese men aged 50 - 84 years with LUTS/BPH . Two hundred patients were r and omized to receive daily treatment with 4 mg doxazosin-GITS ( n=100 ) or 0.2 mg tamsulosin ( n=100 ) for 8 weeks . Nocturia was assessed by question 7 of the International Prostate Symptom Score ( IPSS- question 7 ) and a frequency-volume chart ( FVC ) at weeks 4 and 8 . Self-reported quality of sleep and quality of life by the last question of the IPSS question naire were also evaluated . RESULTS A total of 189 patients ( 94 receiving doxazosin-GITS , 95 tamsulosin ) completed the study . The reduction from baseline in mean nocturia was greater with doxazosin-GITS than tamsulosin by the FVC ( 1.7 vs 1.3 at week 4 ; 2.1 vs 1.7 at week 8 , both P=.001 ) and by the IPSS- question 7 ( 1.5 vs 1.1 at 4 weeks , P=.001 ; 2.0 vs 1.6 at 8 weeks , P<.001 ) . The patients who reported improved quality of sleep was significantly more with doxazosin-GITS than tamsulosin ( 43.6 % vs 27.4 % at 4 weeks , P=.020 ; 81.9 % vs 67.4 % at 8 weeks , P=.022 ) , and quality of life was better with doxazosin-GITS ( 2.5 vs 2.8 at 4 weeks , P=.001 ; 2.1 vs 2.5 at 8 weeks , P<.001 ) . CONCLUSION In Chinese patients with LUTS/BPH , doxazosin-GITS is slightly better than tamsulosin in reducing the frequency of nocturia
Although this study did not consider placebo effect and has high IPSS baseline scores , this study clarifies that low-dose tamsulosin has generally positive effect and safety in treatment of LUTS and could be a suitable option as an initial treatment , especially for patients with low body mass index , as is typical of Asian people
PURPOSE In Asian countries , low-dose tamsulosin ( 0.2 mg ) is used widely but this dose has been less popular than 0.4 mg tamsulosin or other types of alpha blockers .
The aim of this study was to investigate the efficacy and safety of low-dose tamsulosin by systematic review and meta- analysis .