Conclusion : This meta‐ analysis has shown that fibrate treatment  significantly decreases fasting plasma glucose , insulin levels , and HOMA‐IR indicating additional clinical therapeutic benefits .
Aims : The aim of this meta‐ analysis of r and omized placebo‐controlled clinical trials was to assess the effect of fibrates on glycemic parameters .
Lowering of triglycerides by gemfibrozil affects neither the glucoregulatory nor antilipolytic effect of insulin in Type 2 (non-insulin-dependent) diabetic patients
Summary Hypertriglyceridaemia and insulin resistance are closely associated but it is unknown whether hypertriglyceridaemia per se contributes to insulin resistance . In the present study we examined whether gemfibrozil , by lowering triglyceride levels , improves the glucoregulatory and antilipolytic action of insulin in Type 2 ( non-insulin-dependent ) diabetes mellitus . Twenty patients were r and omly allocated to receive either placebo or gemfibrozil 1200 mg daily for 12 weeks in a double-blind study . Very low density lipoprotein triglyceride levels decreased in the gemfibrozil group by 42±12 % ( p<0.01 ) . Gemfibrozil had no effect on the diurnal concentration of non-esterified fatty acids ( NEFA ) . At the r and omization HbA1c levels were comparable ( 7.6±0.3 vs 7.8±0.2 % , NS ) and increased slightly both in the gemfibrozil ( 8.2±0.4 % , p<0.05 ) and placebo groups ( 8.0±0.3 % , NS ) . Pre- and post-treatment diurnal glucose and insulin concentrations remained unchanged . Basal pre- and post-treatment hepatic glucose production rates were comparable in both groups and similarly suppressed by insulin . Rate of whole body glucose disposal during a low-dose insulin infusion ( serum insulin ∼90 pmol/l ) ( pre- vs post-gemfibrozil 11.9±1.1 vs 11.1±0.7 , pre- vs post-placebo 9.9±1.1 vs 10.8±0.8 μmol·kg−1·min−1 , NS for both ) and a high-dose insulin infusion ( serum insulin ∼500 pmol/l ) ( 16.2 + -1.7 vs 17.7±2.7 , 17.1±4.2 vs 17.4±2.9 μmol·kg−1·min−1 , respectively , NS for both ) remained unchanged . Basal pre- and post-treatment NEFA turnover rates were comparable in both groups and similarly suppressed by insulin . Also rates of total lipid oxidation , plasma NEFA oxidation and non-oxidative NEFA metabolism remained unchanged in both groups . We conclude that gemfibrozil effectively lowers serum triglycerides but has no effect on insulin sensitivity of glucose and NEFA metabolism . The data suggest that hypertriglyceridaemia is a consequence rather than a cause of insulin resistance in Type 2 diabetic patients
Conclusion : This meta‐ analysis has shown that fibrate treatment  significantly decreases fasting plasma glucose , insulin levels , and HOMA‐IR indicating additional clinical therapeutic benefits .
Aims : The aim of this meta‐ analysis of r and omized placebo‐controlled clinical trials was to assess the effect of fibrates on glycemic parameters .