Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes
To examine the role of intramyocellular lipid ( IMCL ) accumulation as well as circulating cytokines , branched-chain amino acids and acylcarnitines in the pathogenesis of muscle insulin resistance in healthy , young , lean insulin-resistant offspring of parents with type 2 diabetes ( IR offspring ) , we measured these factors in plasma and used 1H magnetic resonance spectroscopy to assess IMCL content and hyperinsulinemic-euglycemic clamps using [ 6,6 - 2H2 ] glucose to assess rates of insulin-stimulated peripheral glucose metabolism before and after weight reduction . Seven lean ( body mass index < 25 kg/m2 ) , young , sedentary IR offspring were studied before and after weight stabilization following a hypocaloric ( 1,200 Kcal ) diet for ∼9 wks . This diet result ed in an average weight loss of 4.1 ± 0.6 kg ( P < 0.0005 ) , which was associated with an ∼30 % reduction of IMCL from 1.1 ± 0.2 % to 0.8 ± 0.1 % ( P = 0.045 ) and an ∼30 % improvement in insulin-stimulated muscle glucose uptake [ 3.7 ± 0.3 vs. 4.8 ± 0.1 mg/(kg – min ) , P = 0.01 ] . This marked improvement in insulin-stimulated peripheral insulin responsiveness occurred independently of changes in plasma concentrations of TNF-α , IL-6 , total adiponectin , C-reactive protein , acylcarnitines , and branched-chain amino acids . In conclusion , these data support the hypothesis that IMCL accumulation plays an important role in causing muscle insulin resistance in young , lean IR offspring , and that both are reversible with modest weight loss
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .