There were no statistically significant differences in mortality , infections overall and adverse events .
Perioperative antibiotic prophylaxis of ≥24 hours may be more efficacious in preventing sternal SSIs in patients undergoing cardiac surgery compared to shorter regimens .
OBJECTIVE We aim ed to compare the efficacy of short-term ( < 24 hours ) versus longer-term antibiotic prophylaxis ( ≥24 hours ) in open heart surgery .
BACKGROUND The optimal duration of antibiotic prophylaxis for adults undergoing cardiac surgery is unknown and guideline recommendations are inconsistent .
Comparison of ceftriaxone and cefazolin prophylaxis against infection in open heart surgery.
One hundred four patients undergoing elective open heart surgery were enrolled in a prospect i ve , double-blind trial comparing prophylaxis against infection using a single 1 g dose of ceftriaxone and seven doses of cefazolin . Patients in both groups had similar risk factors for infection . The likelihood of achieving a tissue concentration in excess of the minimal inhibitory concentration for Staph . aureus was significantly greater with ceftriaxone in atrial appendage ( p less than 0.001 ) , muscle ( p less than 0.01 ) , and bone ( p less than 0.01 ) than with cefazolin . The serum half-life of ceftriaxone was approximately 15.7 hours . All 49 serum sample s obtained 18 to 24 hours after delivery of ceftriaxone and 26 of 33 sample s obtained 40 to 48 hours after delivery had drug concentrations in excess of 3.1 micrograms/ml , the mean minimal inhibitory concentration for isolates of Staph . aureus . Early and late infectious complications were infrequent and occurred at similar rates in both groups . Neither drug was associated with significant toxicity . A single 1 g dose of ceftriaxone was as effective and safe as multiple doses of cefazolin and demonstrated superior tissue penetration
There were no statistically significant differences in mortality , infections overall and adverse events .
Perioperative antibiotic prophylaxis of ≥24 hours may be more efficacious in preventing sternal SSIs in patients undergoing cardiac surgery compared to shorter regimens .
OBJECTIVE We aim ed to compare the efficacy of short-term ( < 24 hours ) versus longer-term antibiotic prophylaxis ( ≥24 hours ) in open heart surgery .
BACKGROUND The optimal duration of antibiotic prophylaxis for adults undergoing cardiac surgery is unknown and guideline recommendations are inconsistent .