We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .
BIOCHEMICAL AND HÆMATOLOGICAL CHANGES INDUCED BY TIENILIC ACID COMBINED WITH PROPRANOLOL IN ESSENTIAL HYPERTENSION
Sixteen patients with moderate essential hypertension completed a double-blind crossover trial with four treatment periods each of 6 weeks . They received in r and om order : placebo ; tienilic acid 250 mg/day ; propranolol 80 mg twice daily ; and tienilic acid 250 mg/day combined with propranolol 80 mg twice daily . Average blood-pressure in the lying position was 22.6/13.1 kPa ( 169/98 mm Hg ) on placebo ; 21.0/12.5 ( 157/94 ) on tienilic aicd ; 21.2/12.0 ( 159/90 ) on propranolol , and 18.9/11.5 ( 142/86 ) on tienilic acid combined with propranolol . The effects of tienilic acid and propranolol on blood-pressure were additive and there were no statistically significant interactions . Tienilic acid significantly reduced serum-urate from 0.33 to 0.18 mmol/l and induced hypokalaemia which was corrected by propranolol .  Basophil count and haemoglobin were lower after tienilic acid treatment than they had been at the start of the study
We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .