Although a variety of pain and physical functioning outcome measures have been reported in the literature , few have demonstrate method ologically strong psychometric properties .
INTRODUCTION A range of outcome measures across various domains are used to evaluate change following an intervention in clinical trials on chronic neuropathic pain ( NeP ) .
However , to capture a real change in the variable of interest , the psychometric properties of a particular measure should demonstrate appropriate method ological quality .
Various outcome measures in the domains of pain and physical functioning have been used in the literature for NeP , for which individual properties ( eg , reliability/validity ) have been reported .
Development of a measure of the burden of pain due to herpes zoster and postherpetic neuralgia for prevention trials: adaptation of the brief pain inventory.
UNLABELLED In preparation for clinical trials of a vaccine against herpes zoster ( HZ ) , we conducted a prospect i ve , observational study to evaluate ( 1 ) the Zoster Brief Pain Inventory ( ZBPI ) , an HZ-specific question naire to quantify HZ pain and discomfort , ( 2 ) an operational definition of postherpetic neuralgia ( PHN ) , and ( 3 ) a severity- duration measure of the burden of illness caused by HZ . HZ patients aged 60 years or older ( n = 121 ) were enrolled within 14 days of rash onset and completed ZBPI , McGill Pain Question naire Present  Pain Intensity  ( PPI ) ,  quality of life ( QoL ) , and activities of daily living ( ADL ) question naires on a predetermined schedule . Reliability , measured by intraclass correlation coefficients within 14 days of rash onset , ranged between 0.63 and 0.78 . ZBPI pain scores were strongly correlated with other pain measures , interference with ADL , and worsening QoL. The operational definition of PHN , a ZBPI pain score of 3 or greater occurring 90 or more days after rash onset , had high agreement with pain worse than mild on the PPI ( kappa = 0.72 ) . The ZBPI pain severity- duration measure had high correlations with severity- duration measures of ADL interference , worsening QoL , and other pain scales . These findings support the validity and utility of the ZBPI , the definition of PHN , and the severity- duration measure of the burden of HZ illness . PERSPECTIVE Herpes zoster pain , as measured by the ZBPI severity- duration measure , is associated with impairment in daily living activities and quality of life . The ZBPI measure appears useful for quantifying herpes zoster pain , postherpetic neuralgia , and impairment in daily living activities for clinical trials of herpes zoster prevention
Although a variety of pain and physical functioning outcome measures have been reported in the literature , few have demonstrate method ologically strong psychometric properties .
INTRODUCTION A range of outcome measures across various domains are used to evaluate change following an intervention in clinical trials on chronic neuropathic pain ( NeP ) .
However , to capture a real change in the variable of interest , the psychometric properties of a particular measure should demonstrate appropriate method ological quality .
Various outcome measures in the domains of pain and physical functioning have been used in the literature for NeP , for which individual properties ( eg , reliability/validity ) have been reported .