RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .
Comparative efficacy of olmesartan, losartan, valsartan, and irbesartan in the control of essential hypertension.
In a multicenter , r and omized , double-blind trial , the authors compared the antihypertensive efficacy of once-daily treatment with the new angiotensin II type 1 receptor blocker ( ARB ) olmesartan ( 20 mg ) with recommended starting doses of losartan ( 50 mg ) , valsartan ( 80 mg ) , and irbesartan ( 150 mg ) in 588 patients with a cuff diastolic blood pressure ( DBP ) of greater than or equal to 100 and less than or equal to 115 mm Hg and a mean daytime DBP of greater than or equal to 90 mm Hg and less than 120 mm Hg , as measured by ambulatory blood pressure monitoring .  Cuff and ambulatory blood pressures were monitored at baseline and after 8 weeks of treatment . All groups were predominantly white and approximately 62 % male , and their mean age was approximately 52 years . In all groups , mean baseline DBP and systolic blood pressure ( SBP ) were approximately 104 and 157 mm Hg , respectively . The reduction of sitting cuff DBP with olmesartan ( 11.5 mm Hg ) , the primary efficacy variable of this study , was significantly greater than with losartan , valsartan , and irbesartan ( 8.2 , 7.9 , and 9.9 mm Hg , respectively ) . Reductions of cuff SBP with the four ARBs ranged from 8.4 - 11.3 mm Hg and were not significantly different . The reduction in mean 24-hour DBP with olmesartan ( 8.5 mm Hg ) was significantly greater than reductions with losartan and valsartan ( 6.2 and 5.6 mm Hg , respectively ) and showed a trend toward significance when compared to the reduction in DBP with irbesartan ( 7.4 mm Hg ; p=0.087 ) . The reduction in mean 24-hour SBP with olmesartan ( 12.5 mm Hg ) was significantly greater than the reductions with losartan and valsartan ( 9.0 and 8.1 mm Hg , respectively ) and equivalent to the reduction with irbesartan ( 11.3 mm Hg ) . All drugs were well tolerated . The authors conclude that olmesartan , at its starting dose , is more effective than the starting doses of the other ARBs tested in reducing cuff DBP in patients with essential hypertension
RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .