This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
Vitamin D Receptor Fok-I Polymorphism Modulates Diabetic Host Response to Vitamin D Intake
OBJECTIVE Inter population as well as interindividual variations in response to vitamin D intake commonly observed in subjects with type 2 diabetes may be related to genetic makeup . One of the c and i date genes potentially responsible for this diversity is vitamin D receptor ( VDR ) . This study aim ed to investigate the interactive effect of VDR Fok-I polymorphism and vitamin D intake on diverse aspects of diabetic host response . RESEARCH DESIGN AND METHODS Glycemic status , lipid profiles , inflammatory biomarkers , and VDR Fok-I genotypes were determined in diabetic subjects ( n = 140 ) who participated in a r and omized controlled trial . Participants consumed two 250-mL bottles per day of yogurt drink ( doogh ) fortified with 500 IU vitamin D/250 mL for 12 weeks . RESULTS Mean serum 25(OH)D increased by ~30 nmol/L ( P < 0.001 ) . The time × intervention effect was significant for 25(OH)D ( P = 0.030 ) , HDL ( P = 0.011 ) , high-sensitivity C-reactive protein ( hsCRP ) ( P < 0.001 ) , interleukin (IL)-4 ( P = 0.008 ) , and IL-6 ( P = 0.017 ) among the genotypic groups . The alleles were defined as ‘ ‘ F ’ ’ or ‘ ‘ f ’ ’ depending on the absence or presence of the restriction site , respectively . The least increment in 25(OH)D was in ff ( 23.0 ± 3.8 nmol/L ) compared with Ff ( 31.2 ± 3.4 nmol/L ) and FF ( 35.6 ± 2.7 nmol/L ) ( P for trend = 0.009 ) , but only the difference between ff and FF was significant ( P = 0.023 ) . FF group had the largest decrement of both hsCRP and IL-6 compared with Ff ( P < 0.001 and P = 0.038 ) and ff ( P = 0.010 and P = 0.048 ) , respectively . CONCLUSIONS We concluded that those of VDR ff genotype may be regarded as “ low responders ” to vitamin D intake in terms of response of circulating 25(OH)D and certain inflammatory biomarkers . A nutrigenetic approach may , therefore , be needed to protect diabetic patients from vitamin D deficiency
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .