Conclusions : Isoflavone treatments exert a moderately beneficial effect against  estrogen-deficient bone loss in women .
The effect appears dependent on whether isoflavone treatments are in aglycone form ; we conclude that beneficial effects against bone loss may be enhanced for isoflavone aglycones
Background : Age-related estrogen deficiency leads to accelerated bone resorption .
There is evidence that , through selective estrogen receptor modulation , isoflavones may exert beneficial effects against  estrogen-deficient bone loss .
Isoflavone aglycones show higher bioavailability than their glycosidic counterparts and thus may have greater potency .
Objective : To summarize evidence , we executed a systematic review and meta- analysis examining isoflavone therapies and bone mineral density ( BMD ) loss in peri- and postmenopausal women .
Effects of soya isoflavones and exercise on body composition and clinical risk factors of cardiovascular diseases in overweight postmenopausal women: a 6-month double-blind controlled trial.
Results from a pilot project indicate that isoflavones and exercise could have an additive effect on body composition and clinical risk factors of CVD in postmenopausal women . The objective of the present study was to assess the combined effect of exercise and isoflavones in overweight-to-obese postmenopausal women . In this double-blind r and omised controlled trial , 100 overweight-to-obese ( BMI 29·9 ( sd 3·2 ) kg/m2 ) postmenopausal women were assigned to four groups : ( 1 ) placebo ( PLA ) ; ( 2 ) isoflavones ( ISO ) ; ( 3 ) exercise and placebo ( Ex+PLA ) ; ( 4 ) exercise and isoflavones ( Ex+ISO ) . The supplementation contained 70 mg/d of isoflavones . Exercise consisted of three weekly sessions of resistance training and aerobics . Outcome measures included fat mass ( FM ) , lean body mass ( LBM ) , bone mineral density , lipid profile , fasting glucose , fasting insulin and insulin resistance ( homeostasis assessment model ) . The main effects of exercise were observed for total FM ( P = 0·02 ) , FM% ( P < 0·01 ) , trunk FM% ( P = 0·05 ) , arm FM% ( P < 0·01 ) , leg FM% ( P = 0·02 ) , arm LBM ( P < 0·01 ) , leg LBM ( P = 0·02 ) and C-reactive protein ( P < 0·01 ) . A main effect was detected for isoflavones in improving leg FM% ( P = 0·05 ) . No interactions were observed between isoflavones and exercise . In conclusion , it was observed that 6 months of exercise brought favourable changes in total FM , FM% and LBM in overweight postmenopausal women . No synergistic effects were observed between exercise and isoflavones . However , isoflavones could have a beneficial effect on leg FM%
Conclusions : Isoflavone treatments exert a moderately beneficial effect against  estrogen-deficient bone loss in women .
The effect appears dependent on whether isoflavone treatments are in aglycone form ; we conclude that beneficial effects against bone loss may be enhanced for isoflavone aglycones
Background : Age-related estrogen deficiency leads to accelerated bone resorption .
There is evidence that , through selective estrogen receptor modulation , isoflavones may exert beneficial effects against  estrogen-deficient bone loss .
Isoflavone aglycones show higher bioavailability than their glycosidic counterparts and thus may have greater potency .
Objective : To summarize evidence , we executed a systematic review and meta- analysis examining isoflavone therapies and bone mineral density ( BMD ) loss in peri- and postmenopausal women .