The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .
A randomized, double-blind study of valsartan versus metoprolol on arterial distensibility and endothelial function in essential hypertension.
BACKGROUND Antihypertensive drugs may have differential , pressure-independent effects on hypertension-associated alterations of arterial function . We compared the effects of a 12-week therapy with the AT(1)-receptor antagonist valsartan ( Val ) versus the beta-blocker metoprolol ( Met ) on arterial stiffness and endothelial function in mildly hypertensive patients at rest and during generalized sympathetic stimulation . METHODS Sixty-eight patients ( 37 male , 31 female , 46 + /- 6 years ) were r and omized to Val ( 80 - 160 mg/d ) or Met ( 50 - 100 mg/d ) . Effects of therapy on endothelial function , brachial and carotid artery distensibility coefficients , pulse wave velocity , carotid intima-media thickness and elastic modulus were assessed at rest and during the cold pressor test . RESULTS Fifty-two patients were available for per protocol analysis . Blood pressure was comparably reduced in both treatment groups . Effects on endothelial function and large artery elastic wall properties did not differ significantly between the two antihypertensive treatment regimens . Trends did not differ significantly between groups for any parameter including carotid intima-media thickness and elastic modulus . CONCLUSION Short-term treatment with Val and Met had similar effects on large artery functional vessel wall properties in a population of mildly hypertensive patients
The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .