Antihypertensive drugs reduce headache but it is unclear whether there are differences between drug classes .
Calcium channel blockers ( CCBs ) decrease variability in systolic blood pressure ( SBPV ) and stroke risk more than other classes , possibly due to decreased vascular tone .
If so , there might be a correlation between drug-class effects on variability in SBP and on headache .
Antihypertensive drugs reduce headache but the effect differs between classes , corresponding to their effects on SBPV and the risk of stroke .
This may partly be explained by consistent antihypertensive class effects on vascular tone in the peripheral ( variability ) and cerebrovascular circulations ( headache )
Verapamil prophylaxis of migraine. A double-blind, placebo-controlled study.
We undertook a double-blind , placebo-controlled study to determine the effectiveness of verapamil hydrochloride for the prophylaxis of  migraine . Twelve patients were given either verapamil hydrochloride  , 80 mg four times daily , or placebo in r and om order during two consecutive three-month periods . Migraine frequency , severity , and duration were quantified by daily logs and monthly question naires . Ten of the 12 patients had fewer migraines during verapamil therapy . Migraine frequency decreased from 6.7 to 3.8 migraines per patient per month , for a mean decrease of 49 % . Headache unit index fell from an average of 0.61 to 0.44 . We conclude that verapamil is effective in the prophylaxis of migraine and that verapamil might be considered one alternative in the development of a regimen for the prophylaxis of migraine
Antihypertensive drugs reduce headache but it is unclear whether there are differences between drug classes .
Calcium channel blockers ( CCBs ) decrease variability in systolic blood pressure ( SBPV ) and stroke risk more than other classes , possibly due to decreased vascular tone .
If so , there might be a correlation between drug-class effects on variability in SBP and on headache .
Antihypertensive drugs reduce headache but the effect differs between classes , corresponding to their effects on SBPV and the risk of stroke .
This may partly be explained by consistent antihypertensive class effects on vascular tone in the peripheral ( variability ) and cerebrovascular circulations ( headache )