Conclusions : International differences in prescriber behaviour may influence , and in turn be influenced by , the conduct of clinical trials .
Objective : International differences are thought to exist in dosages used by clinicians treating mood disorders .
This study examined international dosage differences in antidepressant clinical trials , using a data base formed and maintained as a component of a Cochrane review of comparative clinical trials of fluoxetine .
A comparative trial of a new antidepressant, fluoxetine.
A double-blind clinical trial was undertaken to evaluate clinical efficacy and safety of fluoxetine in comparison with the st and ard tricyclic antidepressant , imipramine , in the treatment of depressive illness . The opportunity was taken to compare the relationship of some st and ard measures of depressive illness , two observer based -- Hamilton Depression Rating Scale and the Montgomery-Asberg Depression Rating Scale ( Montgomery and Asberg , 1979)-- and a self-rating scale -- Levine Pilowsky Depression question naire ( Pilowsky et al. , 1969 )
Conclusions : International differences in prescriber behaviour may influence , and in turn be influenced by , the conduct of clinical trials .
Objective : International differences are thought to exist in dosages used by clinicians treating mood disorders .
This study examined international dosage differences in antidepressant clinical trials , using a data base formed and maintained as a component of a Cochrane review of comparative clinical trials of fluoxetine .