Results Prophylactic antibiotics  prevent inflammatory complications after gynaecological surgery .
Prophylactic antibiotics are more effective in surgery requiring access to the peritoneal cavity or the vagina .
Cefotetan appears to be more capable in preventing the overall inflammatory complication rate than cefoxitin or cefazolin .
No benefit has been shown for the combination of antibiotics as prophylaxis .
No difference has been shown between the long-term and short-term use of antibiotics .
There is no need for the primary use of an anaerobic antibacterial agent .
Conclusion Antibiotics help to prevent postoperative inflammatory complications after major gynecologic surgeries
Purpose The aim of this study was to systematic ally review the literature on antibiotic prophylaxis in gynaecologic surgeries to prevent inflammatory complications after gynaecological operations .
Ampicillin combined with sulbactam or metronidazole for single-dose chemoprophylaxis in major gynaecological surgery.
A double-blind , placebo-controlled and r and omized trial involving a total of 295 patients was carried out to define the role of chemoprophylaxis in major gynaecological surgery in our hospital . Perioperative administration of a single dose of ampicillin ( 500 mg ) plus sulbactam ( 500 mg ) ( regimen A ) , or ampicillin ( 500 mg ) plus metronidazole ( 1 g suppository ) ( regimen B ) , gave similar results . After abdominal hysterectomy , the rates of post-operative wound infection and febrile morbidity were significantly reduced from 24 % ( 12/49 ) and 20 % ( 10/49 ) in the placebo group to 3 - 4 % ( A = 2/51 , B = 3/58 ) and 2 % ( A = 1/51 , B = 1/58 ) respectively . After vaginal hysterectomy , pelvic/vaginal infection or febrile morbidity was found in 30 % ( 3/10 ) of patients in the placebo group but none in either treatment group ( A = 10 , B = 8) . After other types of operation , the rates of infectious complications were reduced , but not statistically significantly , from 11 % ( 4/38 ) to 4 % ( A + B 2/71 ) . However , the rates of post-operative urinary tract infection remained similar in the placebo and treatment groups ( 12 - 16 % )
Results Prophylactic antibiotics  prevent inflammatory complications after gynaecological surgery .
Prophylactic antibiotics are more effective in surgery requiring access to the peritoneal cavity or the vagina .
Cefotetan appears to be more capable in preventing the overall inflammatory complication rate than cefoxitin or cefazolin .
No benefit has been shown for the combination of antibiotics as prophylaxis .
No difference has been shown between the long-term and short-term use of antibiotics .
There is no need for the primary use of an anaerobic antibacterial agent .
Conclusion Antibiotics help to prevent postoperative inflammatory complications after major gynecologic surgeries
Purpose The aim of this study was to systematic ally review the literature on antibiotic prophylaxis in gynaecologic surgeries to prevent inflammatory complications after gynaecological operations .