Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Randomised Controlled Trial Comparing Daily Versus Depot Vitamin D3 Therapy in 0–16-Year-Old Newly Settled Refugees in Western Australia Over a Period of 40 Weeks
Vitamin D deficiency is highly prevalent in newly settled refugees in Western Australia ( WA ) . If adherence to daily vitamin D therapy is problematic , depot therapy is a therapeutic alternative . The aim of this study was to compare daily versus depot treatment and factors influencing the therapeutic outcome . Newly settled refugees ( n = 151 ) with 25(OH)D levels less than 78 nmol/L were r and omised to receive daily or depot vitamin D therapy with eight weekly interval follow up to 40 weeks . Biochemical and clinical parameters were collected at each visit . Generalized Linear Mixed Models ( GLMM ) examined the longitudinal changes over time controlling for confounders including age , gender , treatment arm , season , country of refuge/origin and sun exposure score . Participants were aged 5.5 months to 16.0 years ( 75 males , 83 females ) . Both treatment groups achieved vitamin D sufficiency . The daily treatment group had significantly higher 25(OH)D levels at each visit post baseline and a higher proportion of participants with levels above 50 nmol/L at all time points . Time , treatment group , calcium and sun exposure score were significant predictors of 25(OH)D serum levels .  Depot vitamin D therapy is an alternative to daily treatment in this at-risk group of children and adolescents in whom treatment adherence is problematic
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .