The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .
α-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat diet
The purpose of this study was to investigate the effects of α-lipoic acid on body weight and lipid profiles in Sprague-Dawley rats fed a high fat diet ( HFD ) .  After 4 weeks of feeding , rats on the HFD were divided into three groups by r and omized block design ; the first group received the high-fat-diet ( n = 10 ) , and the second group received the HFD administered with 0.25 % α-lipoic acid ( 0.25LA ) , and the third group received the high-fat diet with 0.5 % α-lipoic acid ( 0.5LA ) . The high fat diet with α-lipoic acid supplemented groups had significantly inhibited body weight gain , compared to that in the HFD group ( P < 0.05 ) . Organ weights of rats were also significantly reduced in liver , kidney , spleen , and visible fat tissues in rats supplemented with α-lipoic acid ( P < 0.05 ) . Significant differences in plasma lipid profiles , such as total lipids , total cholesterol , triglycerides , low-density lipoprotein , and high-density lipoprotein , were observed between the HFD and 0.5LA groups . The atherogenic index and the plasma high density lipoprotein-cholesterol/total cholesterol ratio improved significantly with α-lipoic acid supplementation in a dose-dependent manner ( P < 0.05 ) . Total hepatic cholesterol and total lipid concentration decreased significantly in high fat fed rats supplemented with α-lipoic acid in a dose-dependent manner ( P < 0.05 ) , whereas liver triglyceride content was not affected . In conclusion , α-lipoic acid supplementation had a positive effect on weight gain and plasma and liver lipid profiles in rats
The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .