Findings were mixed and showed various effects of cannabinoid administration on several aspects of sleep .
This paper review s the literature regarding the effects of cannabinoid administration on  sleep in humans .
An open-label comparison of nabilone and gabapentin as adjuvant therapy or monotherapy in the management of neuropathic pain in patients with peripheral neuropathy.
Neuropathic pain ( NeP ) is prevalent in patients with peripheral neuropathy ( PN ) , regardless of etiology . We sought to compare the efficacy of the cannabinoid nabilone as either monotherapy or adjuvant therapy with a first-line medication for NeP , gabapentin , in a patient population with PN-NeP. Patients diagnosed with PN-NeP were permitted to initiate monotherapy ( nabilone or gabapentin ) or add one of these two medications ( adjuvant therapy ) to their existing NeP treatment regimen in a non-r and omized open-label nature . Baseline data collected included a primary outcome ( visual analog scores [ VAS ] of pain ) and secondary outcomes ( quality of life [ EuroQol 5 Domains and Short-Form 36 ] assessment s and assessment s of sleep [ Medical Outcomes Sleep Study Scale { MOSSS } ] , anxiety and depression [ Hospital Anxiety and Depression Scale ] , and pain [ Brief Pain Inventory ] ) . Re assessment and modulation of dosing and /or medications occurred at 3- and 6-month intervals . Medication adverse effects and drug efficacy , as well as question naires , were assessed at 6 months . Matched analysis of variance testing was performed to compare 3- and 6-month scores with baseline , as well as to compare therapies at equal time points . Significant improvements in pain VAS were seen in all treatment groups at 6 months . Numerous sleep parameters within MOSSS , Brief Pain Inventory , and Short-Form 36 improved in patients receiving nabilone or gabapentin either as monotherapy or adjuvant treatment . Hospital Anxiety and Depression Scale-A scores were significantly improved in all treatment groups . Sleep adequacy and the sleep problems index within the MOSSS improved in nabilone monotherapy patients in particular . The benefits of monotherapy or adjuvant therapy with nabilone appear comparable to gabapentin for management of NeP. We advocate for head-to-head r and omized , double-blind studies for current therapies for NeP in order to determine potential advantages beneficial in this patient population
Findings were mixed and showed various effects of cannabinoid administration on several aspects of sleep .
This paper review s the literature regarding the effects of cannabinoid administration on  sleep in humans .