Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
A Double-Blind, Placebo Controlled, Randomized Trial to Assess the Impact of a Monthly Administration of 50,000 IU of Vitamin D3 for 6 Months on Serum Levels of 25-Hydroxyvitamin D in Healthy Young Adults
In this double blind , unicentre , r and omized , placebo controlled study , we evaluated the changes in 25-hydroxyvitamin D ( 25(OH)D ) serum levels in 150 young Belgian adults ( 18–30 years ) , monthly supplemented with 50,000 IU of vitamin D ( VTD ) or placebo for 6 months , from November 2010 to May 2011 . At T0 , 30 % of the population presented 25(OH)D serum levels below 20 ng/mL. In the VTD-treated group , mean serum levels increased from 21.2 ± 8.2 to 30.6 ± 8.8 ng/mL ( P < 0.001 ) at T3mo and to 36.0 ± 9.2 ng/mL ( P < 0.001 ) at T6mo . Despite documented VTD intake , no changes in serum levels were , however , observed in 10 % of the treated group . In the placebo group , mean 25(OH)D serum levels decreased from 22.8 ± 8.5 to 14.0 ± 6.9 ng/mL at T3mo ( P < 0.001 ) but returned to values not significantly different from those observed at T0 ( 23.5 ± 8.6 ng/mL ) at T6mo . No difference between serum calcium levels was observed between the groups throughout the study . In conclusion , monthly supplementation with 50,000 UI of VTD in winter can warrant serum 25(OH)D levels above 20 ng/mL in 96.2 % of those healthy young adults without inducing unacceptably high 25(OH)D concentration . This supplementation is safe and may be proposed without 25(OH)D testing
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .