Conclusion Probiotic supplementation seemed to be able to reduce the risk of a newborn 's hyperbilirubinemia and improve glycemic control , blood lipid profiles and inflammation and oxidative stress in pregnant women with GDM .
Background Previous studies showed that probiotics could improve glycemic control and attenuate some of the adverse effects of type 2 diabetes .
However , whether the effects are generalizable to gestational diabetes mellitus ( GDM ) remains uncertain .
Objective We conducted a systematic review and meta- analysis to evaluate the effects of probiotic supplement in GDM .
The effects of synbiotic supplementation on insulin resistance/sensitivity, lipid profile and total antioxidant capacity in women with gestational diabetes mellitus: A randomized double blind placebo controlled clinical trial.
AIMS The role of gut microbiota in the management of diabetes is shown . In this r and omized clinical trial we assessed the effects of synbiotic supplementation on insulin , lipid profile and antioxidative status among women with gestational diabetes mellitus ( GDM ) . METHODS Ninety pregnant women with GDM were r and omly assigned into two groups to receive either a daily synbiotic capsule - consisting of L. acidophilus , L. plantarum , L. fermentum , L. gasseri ( 1.5 - 7.0 × 109 - 10 CFU/g ) - with fructooligosaccharide ( 38.5 mg ) , or placebo for 6 weeks . Fasting plasma glucose ( FPG ) , insulin , homeostasis model assessment -insulin resistance ( HOMA-IR ) , quantitative insulin sensitivity check index ( QUICKI ) , high- and low density lipoprotein cholesterol ( HDL-C , LDL-C ) , total cholesterol ( TC ) , triglycerides ( TG ) , total antioxidant capacity ( TAC ) , and systolic and diastolic blood pressure ( SBP , DSP ) were assessed before and after the intervention . RESULTS No significant changes in FPG , insulin resistance/sensitivity , lipid profile and TAC indices were seen in synbiotic group compared to the placebo one ( p > 0.05 ) . Significant within group increases for HDL-C and TAC levels in synbiotic group were observed ( p < 0.05 ) . LDL-C showed significant increment in the placebo group compared to the baseline of the study ( 6.9 mg/dL , p < 0.05 ) . Between group comparison showed significant decrease in SBP and DBP in synbiotic group compared to placebo ( -2.5 vs. 8.6 mmHg , and -1.8 vs. 2.1 mmHg , p < 0.05 ) . CONCLUSIONS The results showed that , in women with GDM , synbiotic supplementation had no effect on FPG and insulin resistance/sensitivity indices . Lipid profile and TAC status may be affected by synbiotic supplementation . Synbiotic is effective in reducing of blood pressure in women with GDM
Conclusion Probiotic supplementation seemed to be able to reduce the risk of a newborn 's hyperbilirubinemia and improve glycemic control , blood lipid profiles and inflammation and oxidative stress in pregnant women with GDM .
Background Previous studies showed that probiotics could improve glycemic control and attenuate some of the adverse effects of type 2 diabetes .
However , whether the effects are generalizable to gestational diabetes mellitus ( GDM ) remains uncertain .
Objective We conducted a systematic review and meta- analysis to evaluate the effects of probiotic supplement in GDM .