Exercise , particularly aerobic exercise , had a significant effect on serum leptin and a possible influence on adiponectin levels , suggesting its therapeutic implication
Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals ; however , results to date are controversial .
Here we performed a systematic review and meta- analysis of the available r and omized controlled trials ( RCTs ) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals .
The Feasibility of an Exercise Intervention in Males at Risk of Oesophageal Adenocarcinoma: A Randomized Controlled Trial
Objective To investigate the feasibility and safety of a 24-week exercise intervention , compared to control , in males with Barrett ’s oesophagus , and to estimate the effect of the intervention , compared to control , on risk factors associated with oesophageal adenocarcinoma development . Methods A r and omized controlled trial of an exercise intervention ( 60 minutes moderate-intensity aerobic and resistance exercise five days/week over 24 weeks ; one supervised and four unsupervised sessions ) versus attention control ( 45 minutes stretching five days/week over 24 weeks ; one supervised and four unsupervised sessions ) in inactive , overweight/obese ( 25.0–34.9 kg/m2 ) males with Barrett ’s oesophagus , aged 18–70 years . Primary outcomes were obesity-associated hormones relevant to oesophageal adenocarcinoma risk ( circulating concentrations of leptin , adiponectin , interleukin-6 , tumour necrosis factor-alpha , C-reactive protein , and insulin resistance [ HOMA ] ) . Secondary outcomes included waist circumference , body composition , fitness , strength and gastro-oesophageal reflux symptoms . Outcomes were measured at baseline and 24-weeks . Intervention effects were analysed using generalised linear models , adjusting for baseline value . Results Recruitment was difficult in this population with a total of 33 participants recruited ( target sample size : n = 80 ) ; 97 % retention at 24-weeks . Adherence to the exercise protocol was moderate . No serious adverse events were reported . A statistically significant intervention effect ( exercise minus control ) was observed for waist circumference ( -4.5 [ 95 % CI -7.5 , -1.4 ] cm ; p < 0.01 ) . Effects on primary outcomes were not statistically significant . Conclusion This small , exploratory trial provides important information to inform future trial development including recruitment rates and estimates of effect sizes on outcomes related to oesophageal adenocarcinoma risk . Future trials should investigate a combined dietary and exercise intervention to achieve greater weight loss in this population and relax inclusion criteria to maximize recruitment . Trial Registration Australian New Zeal and Clinical Trials Registry ( ANZCTR )
Exercise , particularly aerobic exercise , had a significant effect on serum leptin and a possible influence on adiponectin levels , suggesting its therapeutic implication
Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals ; however , results to date are controversial .
Here we performed a systematic review and meta- analysis of the available r and omized controlled trials ( RCTs ) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals .