Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
High dose vitamin D may improve lower urinary tract symptoms in postmenopausal women
Lower urinary tract symptoms ( LUTS ) are common in postmenopausal women , and have been reported inversely associated with vitamin D intake and serum 25-hydroxyvitamin D ( 25(OH)D ) levels . The aim of this study was to investigate if high dose vitamin D supplementation would affect LUTS in comparison to st and ard dose . In a r and omized controlled study including 297 postmenopausal women with low bone mineral density , the participants were allocated to receive capsules of 20 000IU of vitamin D3 twice a week ( high dose group ) or similar looking placebo ( st and ard dose group ) . In addition , all the participants received 1 g of calcium and 800IU of vitamin D daily . A vali date d question naire regarding LUTS was filled in at baseline and after 12 months . At baseline , 76 women in the high dose group and 82 in the st and ard dose group reported any LUTS . Levels of serum 25(OH)D increased significantly more in the high dose group ( from 64.7 to 164.1nmol/l compared to from 64.1 to 81.8nmol/l , p<0.01 ) . No differences between the groups were seen regarding change in LUTS except for a statistically significant reduction in the reported severity of urine incontinence in the high dose group as compared to the st and ard dose group after one year ( p<0.05 ) . The results need confirmation in a study specifically design ed for this purpose
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .