The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Ketanserin and captopril interaction in the treatment of essential hypertensives
Summary The aim of the study was to evaluate whether the combination of ketanserin with captopril exerts an additive antihypertensive effect , as compared with single drug treatment . Twelve patients with uncomplicated moderate essential hypertension received , according to a r and omized , double-blind , crossover design , ketanserin ( 40 mg twice daily ) , captopril ( 50 mg twice daily ) , the combination of the two drugs at these dosages , and the corresponding placebo , each treatment being given for 1 month . Both ketanserin and captopril as monotherapy similarly and significantly reduced blood pressure as compared with placebo ( p<0.001 ) . The combination treatment of ketanserin plus captopril further and significantly reduced blood pressure when compared with single drug treatment ( p<0.001 ) . Moreover , the percentage of responders and patients whose blood pressure was normalized were significantly greater under the combined treatment than under ketanserin or captopril monotherpy ( p<0.001 ) . These data indicate that the combination of ketanserin plus captopril exerts a clear additive antihypertensive effect when compared with each treatment as monotherapy , a finding that suggests this combination can be usefully employed in the treatment of hpertensive patients
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .