Exercise , particularly aerobic exercise , had a significant effect on serum leptin and a possible influence on adiponectin levels , suggesting its therapeutic implication
Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals ; however , results to date are controversial .
Here we performed a systematic review and meta- analysis of the available r and omized controlled trials ( RCTs ) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals .
Effect of Different Doses of Aerobic Exercise on Total White Blood Cell (WBC) and WBC Subfraction Number in Postmenopausal Women: Results from DREW
Background Elevated total white blood cell ( WBC ) count is associated with an increased risk of coronary heart disease and death . Aerobic exercise is associated with lower total WBC , neutrophil , and monocyte counts . However , no studies have evaluated the effect of the amount of aerobic exercise ( dose ) on total WBC and WBC subfraction counts . Purpose To examine the effects of 3 different doses of aerobic exercise on changes in total WBC and WBC subfraction counts and independent effects of changes in fitness , adiposity , markers of inflammation ( IL-6 , TNF-α , C-reactive protein ) , fasting glucose metabolism , and adiponectin . Methods Data from 390 sedentary , overweight/obese postmenopausal women from the DREW study were used in these analyses . Women were r and omized to a non-exercise control group or one of 3 exercise groups : energy expenditure of 4 , 8 , or 12 kcal kg−1⋅week−1 ( KKW ) for 6 months at an intensity of 50 % VO2peak . Results A dose-dependent decrease in total WBC counts ( trend P = 0.002 ) was observed with a significant decrease in the 12KKW group ( −163.1±140.0 cells/µL ; mean±95%CI ) compared with the control ( 138.6±144.7 cells/µL ) . A similar response was seen in the neutrophil subfraction ( trend P = 0.001 ) with a significant decrease in the 12KKW group ( −152.6±115.1 cells/µL ) compared with both the control and 4KKW groups ( 96.4±119.0 and 21.9±95.3 cells/µL , respectively ) and in the 8KKW group ( −102.4±125.0 cells/µL ) compared with the control . When divided into high/low baseline WBC categories ( median split ) , a dose-dependent decrease in both total WBCs ( P = 0.003 ) and neutrophils ( P<0.001 ) was observed in women with high baseline  WBC counts . The effects of exercise dose on total WBC and neutrophil counts persisted after accounting for significant independent effects of change in waist circumference and IL-6 . Conclusion Aerobic exercise training  reduces total WBC and neutrophil counts , in a dose-dependent manner , in overweight/obese postmenopausal women and is especially beneficial for those with systemic low grade inflammation . Clinical Trials Identifier :
Exercise , particularly aerobic exercise , had a significant effect on serum leptin and a possible influence on adiponectin levels , suggesting its therapeutic implication
Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals ; however , results to date are controversial .
Here we performed a systematic review and meta- analysis of the available r and omized controlled trials ( RCTs ) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals .