The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .
Effect of (R)-α-Lipoic Acid Supplementation on Serum Lipids and Antioxidative Ability in Patients with Age-Related Macular Degeneration
Background / Aims : Supplementation with antioxidants is of special interest in preventing or delaying the development and progression of age-related macular degeneration ( AMD ) . This investigation aim ed to assess the effect of α- lipoic acid ( LA ) on serum lipids , serum malondialdehyde ( MDA ) and superoxide dismutase ( SOD ) in patients with AMD . Methods : A total of 62 patients ( 50–75 years old ) with early and intermediate dry form of AMD were r and omly assigned to two groups , i.e. LA administration ( n = 32 ) and placebo ( n = 30 ) . The levels of serum lipids and MDA and SOD activity were measured before and after LA and placebo intervention . Results : Compared with the parameters at baseline , serum total cholesterol ( CHO ) , triglyceride and high- and low-density lipoprotein CHO ( HDL and LDL ) levels were not significantly different after LA and placebo intervention . There was a slight but statistically nonsignificant decrease in serum MDA levels and a statistically significant increase in serum SOD activity after LA intervention . There were no statistically significant differences in serum MDA levels or SOD activity after placebo intervention . Conclusion : The apparent increase in SOD activity caused by LA supplementation indicates that LA may have a possible preventive effect in the development of AMD through an antioxidant mechanism
The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .