Intramuscular testosterone moderately increased lumbar bone density in men ; the results on femoral neck bone density are inconclusive .
Without bone fracture data , the available trials offer weak and indirect inferences about the clinical efficacy of testosterone on osteoporosis prevention and treatment in men
CONTEXT And rogen-deficient men are at increased risk of osteoporosis .
The extent to which testosterone can prevent and treat osteoporosis in men remains unclear .
Testosterone Deficiency As a Risk Factor for Hip Fractures in Men: A Case‐Control Study
The objective of this study was to determine whether decreased gonadal function is a risk factor for hip fracture in elderly men . The study was a matched case-control study performed at an in-hospital orthopedic service at a semi-rural and academic tertiary care center . The patients were seventeen men who presented with hip fractures after simple falls over a 10-month period , 11 men with a history of hip fractures in the preceding 25 months , and 28 r and omly selected age- , race- , and living status-matched control subjects ( mean age 73 years ) . Serum pooled total testosterone ( 9.2 ± 5.5 nmol/ L vs. 12.8 ± 5.4 nmol/L ; p < 0.02 ) and free testosterone ( 37.9 ± 18.8 pmol/L vs. 48.4 ± 20.6 pmol/L ; p < 0.03 ) were significantly lower in hip fracture vs. control patients . Testosterone deficiency was found in 20 ( 71 % ) hip fracture men vs. 9 ( 32 % ) of the controls ( p = 0.003 ; odds ratio 5.3 ) . Analysis of testosterone values within the stratum of absence of any chronic disorder revealed similar results . Serum 25-hydroxyvitamin D levels were significantly lower in the hip fracture group than in control men ( p < 0.001 ) . The conclusion is that gonadal deficiency appears to be an important and heretofore understudied risk factor for hip fractures in men . Prevention of hip fractures in men may involve early recognition and treatment of testosterone
Intramuscular testosterone moderately increased lumbar bone density in men ; the results on femoral neck bone density are inconclusive .
Without bone fracture data , the available trials offer weak and indirect inferences about the clinical efficacy of testosterone on osteoporosis prevention and treatment in men
CONTEXT And rogen-deficient men are at increased risk of osteoporosis .
The extent to which testosterone can prevent and treat osteoporosis in men remains unclear .