In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .
Periodontal regeneration versus extraction and prosthetic replacement of teeth severely compromised by attachment loss to the apex: 5-year results of an ongoing randomized clinical trial.
AIMS Aim of this r and omized , long-term clinical trial was to compare clinical - and patient-based outcomes following periodontal regeneration or extraction and replacement of hopeless teeth with chronic perio-endo lesions and /or attachment loss to or beyond the apex . METHODS Fifty patients presenting with generalized severe periodontitis and at least one hopeless tooth to be extracted for periodontal reasons were entered in this study . The test treatment consisted in the application of a regenerative strategy to 25 hopeless teeth . The control treatment consisted in the extraction of the 25 hopeless teeth and their replacement with conventional or implant-supported fixed partial dentures . RESULTS In the control group , 14 teeth were replaced with implant-supported restorations , eight with tooth-supported bridges , two with Maryl and bridges , while one was not replaced . All fixed partial dentures survived the 5-year follow-up period and 83 % were free from biological complications . In the test group , 23 of the 25 regenerated teeth showed important clinical improvements : the two teeth with unsatisfactory outcomes were extracted at 1 year . The 23 successfully regenerated teeth ( 92 % ) were in good health and function at 5-year examination visit and 84 % did not develop biological complications during the recall period . All patients consistently reported comfort in function at the experimental test and control units . In the test group , average clinical attachment level gains were 7.7±2.8 mm , radiographic bone gain 8.5±3.1 mm , probing pocket depth ( PPD ) reduction 8.8±3 mm . Residual PPDs were 4±1.7 mm . Most of the regenerated teeth showed a decrease in tooth mobility . CONCLUSIONS Regenerative therapy can be applied at hopeless teeth and has the potential to change their prognosis ; it is a suitable alternative to extraction of severely compromised teeth with intra-bony defects to or beyond the root apex
In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .