Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .
Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial
Background / Objectives : The percentage of hypercholesterolemic individuals not reaching their LDL-cholesterol ( LDL-C ) goal remains high and additional therapeutic strategies should be evaluated . The objective of this study was to evaluate the cholesterol-lowering efficacy and mechanism of action of bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 capsules in hypercholesterolemic adults . Subjects/ Methods : A total of 127 subjects completed a r and omized , double-blind , placebo-controlled , parallel-arm , multicenter study . Subjects were r and omized to consume L. reuteri NCIMB 30242 capsules or placebo capsules over a 9-week intervention period . The primary outcome was LDL-C relative to placebo at the study end point . Results : L. reuteri NCIMB 30242 capsules reduced LDL-C by 11.64 % ( P<0.001 ) , total cholesterol by 9.14 % , ( P<0.001 ) , non-HDL-cholesterol ( non-HDL-C ) by 11.30 % ( P<0.001 ) and apoB-100 by 8.41 % ( P=0.002 ) relative to placebo . The ratios of LDL-C/HDL-cholesterol ( HDL-C ) and apoB-100/apoA-1 were reduced by 13.39 % ( P=0.006 ) and 9.00 % ( P=0.026 ) , respectively , relative to placebo . Triglycerides and HDL-C were unchanged . High-sensitivity C-reactive protein and fibrinogen were reduced by 1.05 mg/l ( P=0.005 ) and 14.25 % ( P=0.004 ) relative to placebo , respectively . Mean plasma deconjugated bile acids were increased by 1.00 nmol/l ( P=0.025 ) relative to placebo , whereas plasma campesterol , sitosterol and stigmasterol were decreased by 41.5 % , 34.2 % and 40.7 % , respectively . Conclusions : The present results suggest that the deconjugation of intraluminal bile acids results in reduced absorption of non-cholesterol sterols and indicate that L. reuteri NCIMB 30242 capsules may be useful as an adjunctive therapy for treating hypercholesterolemia
Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .