There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Effect of Supplementation of Preterm Formula With Long Chain Polyunsaturated Fatty Acids on Mineral Balance in Preterm Infants
Background Incorporation of long chain polyunsaturated fatty acids ( LCP ) into formulas may interfere with mineral metabolism . We investigate mineral balance in preterm infants who were fed a formula with LCP .  Methods Infants were r and omized in a double-blind manner , 20 infants in each group , to receive a formula with LCP ( F+LCP ) or without LCP ( F ) for 30 days . Plasma levels ( at the beginning and after 30 days ) and nutritional balance ( after 1 week ) for Ca , P , Mg , Zn , and Cu were obtained for all infants . Results Groups were similar regarding birth weight , gestational age , weight , and corrected age at study start . During the 30-day study period , the groups had comparable milk intake and reached similar and satisfactory weight gains and longitudinal growth . Within each group , there was no change in plasma mineral concentrations over the course of the study , and there were no differences at each time point between groups . All values were within the normal range for age . No differences in mineral balance were detected between the F and F+LCP groups , with both groups demonstrating comparable intake , net retention , and fecal losses of each mineral . Conclusions Adding a content of LCP blend similar to that of human milk to a preterm formula caused no disturbance in Ca , P , Mg , Zn , or Cu nutritional balance
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .