Direct comparison of doses did not show evidence of dose dependence for blood pressure-lowering for any of the other thiazides for which RCT data were available : bendrofluazide , chlorthalidone , cyclopenthiazide , metolazone or indapamide .
This is based on an informal indirect comparison of results observed in other Cochrane review s on ACE inhibitors , ARBs and renin inhibitors compared with placebo , which used similar inclusion /exclusion criteria to the present review .Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides .
These effects were dose-related and were least for hydrochlorothiazide .
Chlorthalidone increased serum glucose but the evidence was unclear for other thiazides .
This systematic review shows that hydrochlorothiazide has a dose-related blood pressure-lowering effect .
Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides
BACKGROUND Hypertension is a modifiable cardiovascular risk factor .
Although it is established that low-dose thiazides reduce mortality as well as cardiovascular morbidity , the dose-related effect of thiazides in decreasing blood pressure has not been subject to a rigorous systematic review .
It is not known whether individual drugs within the thiazide diuretic class differ in their blood pressure-lowering effects and adverse effects .
OBJECTIVES To determine the dose-related decrease in systolic and /or diastolic blood pressure due to thiazide diuretics compared with placebo control in the treatment of patients with primary hypertension .
Secondary outcomes included the dose-related adverse events leading to patient withdrawal and adverse biochemical effects on serum potassium , uric acid , creatinine , glucose and lipids .
[Comparison of the clinical usefulness of diuretics in elderly and younger essential hypertension--double blind trial using tripamide].
本態性高血圧に対する利尿降圧剤 tripamide 1日15～60mg単独投与の有用性を60歳以上の老年者33例 ( 平均年齢65.9歳 ) と59歳以下の壮年者59例 ( 平均年齢50.0歳 ) に於て二重盲検法により検討した.降圧効果 ( 20/10mmHgまたは平均血圧13mmHg以上下降 ) は老年者で84.8 % , 壮年者で59.3%で , 老年者の降圧効果が有意に高いことを認めた ( p<0.05 ) . しかし降圧幅は老年者で32.0/13.2mmHg , 壮年者で26.9/11.2mmHgであり , 有意差を認めず , 老年者で過度の降圧を来さないことを示唆した.臨床検査のうち , 血液学検査では両年齢群とも有意の変動を認めず , 血液濃縮は見られなかった. 生化学検査では老年者では血清Cl , アルカリフォスファターゼの低下と尿素窒素 , 尿酸の上昇を , 壮年者では血清Clの低下と総コレステロール , Ca , 尿酸 , 尿素窒素の上昇を認めた. 血清Na , K , 空腹時血糖値には両年齢群とも変化を認めなかった. 心胸比は老年者で減少した. これらの変化は有意差を認めたものの正常範囲内の変化であり臨床的意義は少ないと思われる.副作用は壮年者で5例8%に認められたが , 老年者では認められなかった. 副作用に臨床検査値の異常変化例を含めると壮年者で9例15 % , 老年者で4例12%でいずれも有意差は見られなかった.従って有用性 ( 有用以上 ) は , 老年者で78.8 % , 壮年者で52.5%と有意差を認め ( p<0.05 ) , 利尿降圧剤 tripamide
Direct comparison of doses did not show evidence of dose dependence for blood pressure-lowering for any of the other thiazides for which RCT data were available : bendrofluazide , chlorthalidone , cyclopenthiazide , metolazone or indapamide .
This is based on an informal indirect comparison of results observed in other Cochrane review s on ACE inhibitors , ARBs and renin inhibitors compared with placebo , which used similar inclusion /exclusion criteria to the present review .Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides .
These effects were dose-related and were least for hydrochlorothiazide .
Chlorthalidone increased serum glucose but the evidence was unclear for other thiazides .
This systematic review shows that hydrochlorothiazide has a dose-related blood pressure-lowering effect .
Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides
BACKGROUND Hypertension is a modifiable cardiovascular risk factor .
Although it is established that low-dose thiazides reduce mortality as well as cardiovascular morbidity , the dose-related effect of thiazides in decreasing blood pressure has not been subject to a rigorous systematic review .
It is not known whether individual drugs within the thiazide diuretic class differ in their blood pressure-lowering effects and adverse effects .
OBJECTIVES To determine the dose-related decrease in systolic and /or diastolic blood pressure due to thiazide diuretics compared with placebo control in the treatment of patients with primary hypertension .
Secondary outcomes included the dose-related adverse events leading to patient withdrawal and adverse biochemical effects on serum potassium , uric acid , creatinine , glucose and lipids .