LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Comparison between morning and evening doses of simvastatin in hyperlipidemic subjects. A double-blind comparative study.
Previous studies have shown that simvastatin , a hydroxymethyl glutaryl coenzyme A reductase inhibitor , reduces plasma cholesterol levels when administered once a day . In the present study , the efficacy and tolerability of a morning and an evening dose were compared . The dosages employed were 2.5 and 5 mg for 12 weeks . This investigation was a double-blind , placebo-controlled study involving 172 hyperlipidemic subjects whose plasma cholesterol levels were higher than 220 mg/dl . During the study period , mean changes in plasma cholesterol level ( from baseline ) were -11 % with the 2.5-mg q.a.m . regimen , -15 % with the 2.5-mg q.p.m . regimen , -14 % with the 5-mg q.a.m . regimen , and -21 % with the 5-mg q.p.m . regimen . Each of these changes was statistically significant when compared with that in the placebo group ( p less than 0.001 ) . In addition , the reduction in cholesterol level was significantly greater with the evening regimen than with the morning regimen for both the 2.5-mg ( p less than 0.05 ) and the 5-mg ( p less than 0.05 ) dosages . The changes in triglyceride and high density lipoprotein cholesterol levels in each group were not significantly different from those in the placebo group . There were no differences in the incidence of clinical adverse reactions among the various treatment groups . In conclusion , when simvastatin was administered orally once per day in the evening , it reduced cholesterol levels to a significantly greater degree than when it was given in the morning
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .