The evidence for the effectiveness of B serrata extracts is encouraging but not compelling
OBJECTIVE To assess evidence from r and omised clinical trials about the effectiveness of  extracts of Boswellia serrata ( frankincense ) .
Single flexible sigmoidoscopy screening to prevent colorectal cancer: baseline findings of a UK multicentre randomised trial.
BACKGROUND This r and omised controlled trial is examining the hypothesis that a single flexible sigmoidoscopy screening offered at around age 60 years can lower the incidence and mortality of  colorectal cancer .  We report here on acceptability , safety , feasibility , and yield . METHODS Men and women aged 55 - 64 years , in 14 UK centres , who responded to a mailed question naire that they would attend for flexible sigmoidoscopy screening if invited , were r and omly assigned screening or control ( ratio one to two ) . The control group was not contacted . Small polyps were removed during screening , and colonoscopy was undertaken if high-risk polyps ( three or more adenomas , size 1 cm or greater , villous , severely dysplastic , or malignant ) were found . FINDINGS Of 354,262 people asked about their interest in having flexible sigmoidoscopy screening , 194,726 ( 55 % ) responded positively , and 170,432 eligible individuals were r and omised .  Attendance among those assigned screening was 71 % ( 40,674 of 57,254 ) . 2131 ( 5 % ) were classified as high-risk and referred for colonoscopy ; 38,525 with no polyps or only low-risk polyps detected were discharged . Distal adenomas were detected in 4931 ( 12.1 % ) and distal cancer in 131 ( 0.3 % ) . Proximal adenomas were detected in 386 ( 18.8 % of those undergoing colonoscopy ) and proximal cancer in nine cases ( 0.4 % ) . 62 % of cancers were Dukes ' stage A or locally excised . There was one perforation after flexible sigmoidoscopy and four after colonoscopy . An average of 48 people were screened , and two or three colonoscopy referrals generated , per centre each week . Interpretation Our flexible sigmoidoscopy screening regimen is acceptable , feasible , and safe . The prevalence of neoplasia is high , and colonoscopy referral rates of 5 % are acceptable
The evidence for the effectiveness of B serrata extracts is encouraging but not compelling
OBJECTIVE To assess evidence from r and omised clinical trials about the effectiveness of  extracts of Boswellia serrata ( frankincense ) .