None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .
A randomized evaluation of the effects of glucose-insulin-potassium infusion on myocardial salvage in patients with acute myocardial infarction treated with reperfusion therapy.
BACKGROUND Intravenous glucose-insulin-potassium ( GIK ) may have a positive metabolic influence in patients with acute myocardial infa rct ion ( AMI ) who receive reperfusion therapy .  The objective of this r and omized trial was to assess for the first time whether GIK improves myocardial salvage in patients with AMI . METHODS The Reevaluation of Intensified Venous Metabolic Support for Acute Infa rct Size Limitation ( REVIVAL ) trial is a r and omized , open-label study conducted among 312 patients with AMI . Patients were r and omly assigned to either the  GIK therapy group ( n = 155 ) or the control group ( n = 157 ) . All patients were intended to receive reperfusion treatment , which was given in all but 5 patients ( 1.6 % ) . The primary end point of the study was salvage index , measured as the proportion of initial perfusion defect ( acute technetium-99 m sestamibi scintigraphy ) salvaged by therapy ( follow-up scintigraphy performed after 7 to 14 days ) . RESULTS The primary end point of the study , the salvage index , was in median 0.50 ( 25th , 75th percentiles : 0.18 , 0.87 ) in the GIK group and 0.48 ( 25th , 75th percentiles : 0.27 , 0.78 ) in the control group ( P = .96 ) . By 6 months , the mortality rate was 5.8 % in the GIK group and 6.4 % in the control group ( P = .85 ; relative risk , 0.92 ; 95 % CI , 0.37 to 2.26 ) . Subgroup analyses showed that GIK therapy was associated with increased salvage index only among diabetic patients ( mean difference , 0.19 ; 95 % CI , 0.01 to 0.37 ) . CONCLUSIONS The routine use of GIK therapy in patients with AMI is not associated with enhanced myocardial salvage . This therapy appears to improve myocardial salvage only among diabetic patients
None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .