Conclusion This study suggests that the probiotics supplementation could potentially reduce the weight gain and improve some of the associated metabolic parameters , which may become an effective strategy for the prevention and treatment of obesity in adult individuals
Background The prevalence of overweight/obesity in adults is raised to 39 % , which is nearly tripled more than 1975 .
The alteration of the gut microbiome has been widely accepted as one of the main causal factors .
To find an effective strategy for the prevention and treatment of overweight/obesity , a systematic review and meta- analysis were design ed .
Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial
Background / Objectives : The population of the obese is increasing worldwide . Prevention and improvement of obesity are indispensable for decreasing the risk of metabolic disorders . We have recently shown that obesity and fatty liver are reduced by a plant-derived lactic acid bacterium , Pediococcus pentosaceus LP28 ( LP28 ) , in high-fat diet-induced obese mice . The aim of the present clinical study is to prove that LP28 is effective for reducing body fat and body weight , as shown in the experiment using mice . Subjects/ Methods : The clinical trial was carried out as a double-blind , r and omized , placebo-controlled study comprising 62 subjects ( 20–70 years of age , BMI 25–30 kg/m2 ) . These subjects were r and omly assigned to three groups that received living LP28 , heat-killed LP28 or a placebo powder , administered orally once a day for 12 weeks . Results : Heat-killed LP28  reduced BMI ( 0.45 kg/m2 , 95 % CI ( 0.04 , 0.86 ) , P=0.035 ) , body fat percentage ( 1.11 % , ( 0.39 , 1.82 ) , P=0.002 ) , body fat mass ( 1.17 kg ( 0.43 , 1.92 ) , P=0.004 ) and waist circumference ( 2.84 cm ( 0.74 , 4.93 ) , P=0.009 ) when compared with a placebo group . Fasting plasma glucose , HbA1c , fasting insulin , HOMA-IR and serum lipids levels did not change by either living LP28 or heat-killed LP28 intake . Conclusions : Heat-killed LP28 displays an antiobesity effect that reduces BMI , body fat and waist circumference , suggesting that the plant-derived lactic acid bacterium LP28 would be a promising preventive of metabolic syndrome
Conclusion This study suggests that the probiotics supplementation could potentially reduce the weight gain and improve some of the associated metabolic parameters , which may become an effective strategy for the prevention and treatment of obesity in adult individuals
Background The prevalence of overweight/obesity in adults is raised to 39 % , which is nearly tripled more than 1975 .
The alteration of the gut microbiome has been widely accepted as one of the main causal factors .
To find an effective strategy for the prevention and treatment of overweight/obesity , a systematic review and meta- analysis were design ed .