Results Insulin resistance indicators were significantly improved after bariatric surgery .
Leptin was also significantly decreased while adiponectin was significantly increased .
Although the level of metabolic hormones changed after bariatric surgery , they were not statistically significant .
Inflammation indicators were significantly decreased .
Significant reduction was also detected in PAI-1 and sICAM-1 .
Conclusions Bariatric surgery is beneficial in morbidly obese patients .
Although treating obesity in a surgical way may cause some complications , the weight loss is generally safe and effective
Background Considering conflicting results on the consequences of all types of obesity surgery , we were to summarize them via a systematic review .
Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis
Background and objective : Systemic inflammation is a well-known risk factor for diseases such as atherosclerosis and is augmented by the presence of obesity . In addition , it has been shown that inflammation may be negatively influenced by certain macronutrients , specifically the omega-3 and omega-6 fatty acids . The primary aim of this study is to determine whether obesity modifies the association between plasma phospholipid polyunsaturated fatty acids ( PUFAs ) and markers of inflammation and endothelial activation in Multi-Ethnic Study of Atherosclerosis ( MESA ) participants .Subjects : A sample of 2848 adults ( 25 % African American , Chinese , Hispanic , and White ) r and omly selected from the MESA cohort . Measurements : Relative plasma PUFA concentrations were determined using gas chromatography-flame ionization detection . Levels of three inflammatory markers ( high-sensitivity C-reactive protein , interleukin (IL)-6 and tumor necrosis factor-receptor 1 ) and two endothelial activation markers ( soluble intercellular adhesion molecule-1 ( sICAM-1 ) and E-selectin ) were determined with enzyme immunoassays . Linear regression analysis was used to evaluate the relationship between these markers and plasma PUFAs . Results : Obesity modified the associations of linoleic acid ( Pint=0.01 ) , dihomo-γ-linolenic ( Pint=0.07 ) and eicosapentaenoic acid ( EPA ) ( Pint=0.04 ) with sICAM-1 concentrations ; in addition , obesity modified the association of IL-6 with dihomo-γ-linolenic ( Pint=0.01 ) . In obese individuals  , sICAM-1 was inversely related to EPA levels ( P=0.02 ) , but directly related to linoleic acid levels ( P<0.001 ) . Conversely , sICAM-1 was inversely related to linoleic acid levels in normal weight individuals ( P=0.04 ) . IL-6 concentrations were significantly and directly related to dihomo-γ-linolenic acid ( DGLA ) in normal weight ( P=0.01 ) and obese participants ( P<0.001 ) , but the scale of increase across tertiles was greater in obese adults . Main effects of fatty acid and inflammatory marker associations are also reported . Conclusion : The modifying effect of obesity on the association of plasma PUFAs with IL-6 and sICAM-1 suggests differences in fatty acid metabolism and may also have implication s in dietary fatty acid intake for obese individuals , particularly for linoleic and EPAs . Further study is warranted to confirm and explain the strong associations of DGLA with inflammatory and endothelial activation markers
Results Insulin resistance indicators were significantly improved after bariatric surgery .
Leptin was also significantly decreased while adiponectin was significantly increased .
Although the level of metabolic hormones changed after bariatric surgery , they were not statistically significant .
Inflammation indicators were significantly decreased .
Significant reduction was also detected in PAI-1 and sICAM-1 .
Conclusions Bariatric surgery is beneficial in morbidly obese patients .
Although treating obesity in a surgical way may cause some complications , the weight loss is generally safe and effective
Background Considering conflicting results on the consequences of all types of obesity surgery , we were to summarize them via a systematic review .