On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
A double-blind, placebo-controlled study of Adderall and methylphenidate in the treatment of attention-deficit/hyperactivity disorder.
OBJECTIVE While Adderall has been available for the treatment of attention-deficit/hyperactivity disorder ( ADHD ) for several years , there are few controlled studies comparing it to methylpheni date . METHOD Fifty-eight children with ADHD ( mean age 8.1 + /- 1.4 years ) were r and omly assigned to receive placebo , methylpheni date , or Adderall in a double-blind , parallel-group design for 3 weeks . Dosage was adjusted at the end of weeks 1 and 2 via an algorithm based on teacher and parent ratings . Final doses were 12.5 + /- 4.1 mg/day for Adderall and 25.2 + /- 13.1 mg/day for methylpheni date .  Teacher and parent ratings , as well as the psychiatrist 's Clinical Global Impression ( CGI ) , were the final outcome measures at the end of week 3 . RESULTS Both medications were superior to placebo at reducing inattentive and oppositional symptoms in the classroom and on the CGI . Adderall produced significantly more improvements on teacher ratings and the CGI than methylpheni date , although the algorithm may have limited dosing in the methylpheni date group . Seventy percent of children in the Adderall group were given medication once a day , compared with 15 % of the subjects receiving methylpheni date . CONCLUSIONS Adderall compared favorably to methylpheni date , and the behavioral effects of Adderall appear to persist longer than those of methylpheni date after individual doses
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .