Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .
Comparative effects of potassium chloride and bicarbonate on thiazide-induced reduction in urinary calcium excretion.
BACKGROUND The chronic low- grade metabolic acidosis that occurs in various renal disorders and in normal people , and that is related both to dietary net acid load and age-related renal functional decline , may contribute to osteoporosis by increasing urine calcium excretion . Administration of potassium ( K ) alkali salts neutralizes acid and lowers urine calcium excretion . Urine calcium excretion also can be reduced by the administration of thiazide diuretics , which are often given with supplemental K to avoid hypokalemia . We determined whether the K alkali salt potassium bicarbonate ( KHCO3 ) and the thiazide diuretic hydrochlorothiazide ( HCTZ ) combined is more effective in reducing urinary calcium than KHCO3 alone or HCTZ combined with the conventionally coadministered nonalkalinizing K salt potassium chloride ( KCl ) . METHODS Thirty-one healthy men and women aged 50 or greater were recruited for a four-week , double-blind , r and omized study . After a baseline period of 10 days with three 24-hour urine and arterialized blood collection s , subjects were r and omized to receive either HCTZ ( 50 mg ) plus potassium ( 60 mmol daily ) as either the chloride or bicarbonate salt . Another 19 women received potassium bicarbonate ( 60 mmol ) alone . After two weeks , triplicate collection s of 24-hour urines and arterialized bloods were repeated . RESULTS Urinary calcium excretion decreased significantly in all groups . KHCO3 alone and HCTZ + KCl induced similar decreases ( -0.70 + /- 0.60 vs. -0.80 + /- 1 . 0 mmol/day , respectively ) . Compared with those treatments , the combination of HCTZ + KHCO3 induced more than a twofold greater decrease in urinary calcium excretion ( -1.8 + /- 1.2 mmol/day , P < 0 . 05 ) . Both HCTZ + KHCO3 and KHCO3 alone reduced net acid excretion significantly ( P < 0.05 ) to values of less than zero . CONCLUSIONS KHCO3 was superior to KCl as an adjunct to HCTZ , inducing a twofold greater reduction in urine calcium excretion , and completely neutralizing endogenous acid production so as to correct the pre-existing mild metabolic acidosis that an acid-producing diet usually induces in older people . Accordingly , for reducing urine calcium excretion in stone disease and osteoporosis , the combination of HCTZ + KHCO3 may be preferable to that of HCTZ + KCl
Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .