On the basis of this review , available scientific data suggest that the administration of currently evaluated probiotic- and /or prebiotic-supplemented formula to healthy infants does not raise safety concerns with regard to growth and adverse effects .
Infant formulae are increasingly supplemented with probiotics , prebiotics , or synbiotics despite uncertainties regarding their efficacy .
The present article , developed by the Committee on Nutrition of the European Society for Paediatric Gastroenterology , Hepatology , and Nutrition , systematic ally review s published evidence related to the safety and health effects of the administration of formulae supplemented with probiotics and /or prebiotics compared with unsupplemented formulae .
Safety and tolerance of the human milk probiotic strain Lactobacillus salivarius CECT5713 in 6-month-old children.
OBJECTIVE Intestinal microbiota plays an important role in the prevention of certain diseases during the pediatric years . Thus , there is an increasing interest in the addition of probiotics to infant formulas . The aim of this study was to evaluate the safety of a follow-on formula with Lactobacillus salivarius CECT5713 in 6-mo-old children . METHODS The antibiotic susceptibility of L. salivarius CECT5713 was analyzed by a dilution method . A double-blinded , r and omized , placebo controlled study was performed . Children ( n = 80 ) were distributed in two groups and consumed the formula supplemented or not with probiotics ( 2 × 10(6 ) colony-forming units [cfu]/g ) during 6 mo . Fecal sample s were collected at enrollment , at 3 mo , and at the end of trial . Clinical and anthropometric evaluations were performed . Depending on the variable , one-way or two-way repeated measures analysis of variance were used for the statistical analysis . RESULTS The antibiotic susceptibility profile of the strain result ed as safe . No adverse effects associated with the consumption of the probiotic formula were reported . In addition , clinical parameters did not differ between groups . Consumption of the probiotic supplemented formula led to an increase in the fecal lactobacilli content ( 7.6 ± 0.2 versus 7.9 ± 0.1 log cfu/g , P < 0.05 ) . Lactobacillus salivarius CECT5713 was detected in the feces of volunteers from the probiotic group . Probiotic consumption induced a significant increase in the fecal concentration of butyric acid at 6 mo . CONCLUSION Thus , a follow-on formula with L. salivarius CECT5713 is safe and well tolerated in 6-mo-old infants
On the basis of this review , available scientific data suggest that the administration of currently evaluated probiotic- and /or prebiotic-supplemented formula to healthy infants does not raise safety concerns with regard to growth and adverse effects .
Infant formulae are increasingly supplemented with probiotics , prebiotics , or synbiotics despite uncertainties regarding their efficacy .
The present article , developed by the Committee on Nutrition of the European Society for Paediatric Gastroenterology , Hepatology , and Nutrition , systematic ally review s published evidence related to the safety and health effects of the administration of formulae supplemented with probiotics and /or prebiotics compared with unsupplemented formulae .