However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .
A Comparison of Fish Oil, Flaxseed Oil and Hempseed Oil Supplementation on Selected Parameters of Cardiovascular Health in Healthy Volunteers
Objective : The impact of dietary polyunsaturated fatty acids ( PUFAs ) of the n-6 and n-3 series on the cardiovascular system is well documented . To directly compare the effects of three dietary oils ( fish , flaxseed and hempseed ) given in concentrations expected to be self-administered in the general population on specific cardiovascular parameters in healthy volunteers . Design : 86 healthy male and female volunteers completed a 12 week double blinded , placebo controlled , clinical trial . They were r and omly assigned to one of the four groups . Subjects were orally supplemented with two 1 gm capsules of placebo , fish oil , flaxseed oil or hempseed oil per day for 12 weeks . Results : Plasma levels of the n-3 fatty acids docosahexanoic acid and eicosapentanoic acid increased after 3 months supplementation with fish oil .  Alpha linolenic acid concentrations increased transiently after flaxseed supplementation . However , supplementation with hempseed oil did not significantly alter the concentration of any plasma fatty acid . The lipid parameters ( TC , HDL-C , LDL-C and TG ) did not show any significant differences among the four groups . Oxidative modification of LDL showed no increase in lag time over the 12 wk period . None of the dietary interventions induced any significant change in collagen or thrombin stimulated platelet aggregation and no increase in the level of inflammatory markers was observed . Conclusion : From a consumer 's perspective , ingesting 2 capsules of any of these oils in an attempt to achieve cardiovascular health benefits may not provide the desired or expected result over a 3 month period
However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .