Conclusions and implication s of key findings : Fluoxetine is associated with a significantly greater reduction in OCD severity , as measured by the CY-BOCS , NIMH-OC and CGI-S , in children and adolescents .
Additionally , it is well tolerated in children and adolescents .
The acceptability is comparable to that of the placebo-treated group .
Background : Obsessive-compulsive disorder ( OCD ) is a common psychiatric illness in children and adolescents .
Previous evidence suggests that fluoxetine is effective in the treatment of OCD in children and adolescents .
However , those studies had small sample sizes .
As a result , a systematic review , which is a more powerful method to calculate the true effect size , can be applied to examine the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Objectives : The aims of this study were to review the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Double-blind study of adjuvant buspirone for fluoxetine-treated patients with obsessive-compulsive disorder.
In a double-blind , crossover study , 13 fluoxetine-treated patients with obsessive-compulsive disorder were given adjuvant buspirone and placebo for 4 weeks each . There were no significant differences between buspirone and placebo in obsessive-compulsive , depressive , or anxiety symptoms
Conclusions and implication s of key findings : Fluoxetine is associated with a significantly greater reduction in OCD severity , as measured by the CY-BOCS , NIMH-OC and CGI-S , in children and adolescents .
Additionally , it is well tolerated in children and adolescents .
The acceptability is comparable to that of the placebo-treated group .
Background : Obsessive-compulsive disorder ( OCD ) is a common psychiatric illness in children and adolescents .
Previous evidence suggests that fluoxetine is effective in the treatment of OCD in children and adolescents .
However , those studies had small sample sizes .
As a result , a systematic review , which is a more powerful method to calculate the true effect size , can be applied to examine the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .
Objectives : The aims of this study were to review the efficacy , acceptability and tolerability of fluoxetine in the treatment of OCD in children and adolescents .