The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .
Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial.
OBJECTIVE The aim of this study was to investigate the effect of alpha-lipoic acid ( ALA ) treatment on endothelium-dependent and -independent vasodilatation , assessed by forearm blood flow ( FBF ) , in patients with type 2 diabetes mellitus . RESEARCH DESIGN AND METHODS A total of 30 subjects with type 2 diabetes were included in this r and omized , controlled , double-blinded , parallel group study . FBF responses to intra-arterial acetylcholine ( ACh ) and glycerol trinitrate ( GTN ) were measured before and after 21 days of intravenous treatment with 600 mg alpha-lipoic acid or placebo . RESULTS FBF responses were comparable at baseline . After treatment , FBF reactivity to ACh and GTN was unchanged in subjects receiving placebo . By contrast , ALA treatment increased endothelium-dependent vasodilatation to ACh ( P < 0.05 ) but not to GTN compared with baseline . CONCLUSIONS Intravenous ALA treatment improves endothelium-dependent vasodilatation in patients with type 2 diabetes , in the absence of effects on forearm vasomotor function . If this salutary action translates into vascular risk reduction remains to be established
The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .