There is low to high ( majority moderate ) certainty for small improvements of unclear clinical importance in plasma glucose , triglycerides , and HDL concentrations favoring low-carbohydrate food at half of the prespecified time points .
There was little to no difference in LDL concentration or any of the secondary outcomes ( body weight , waist circumference , blood pressure , quality of life ) in response to either of the diets ( very-low- to high-certainty evidence ) .
Conclusions Currently available data provide low- to moderate-certainty evidence that dietary carbohydrate restriction to a maximum of 40 % yields slightly better metabolic control of uncertain clinical importance than reduction in fat to a maximum of 30 % in people with T2D .
Background It remains uncertain which diet is best for people with type 2 diabetes ( T2D ) .
Objective We compared the effects of dietary carbohydrate restriction with fat restriction on markers of metabolic syndrome and quality of life in people with T2D .
Mechanisms of increase in plasma triacylglycerol concentrations as a result of high carbohydrate intakes in patients with non-insulin-dependent diabetes mellitus.
To determine the mechanisms of increase in plasma triacylglycerol concentrations after high dietary intakes of carbohydrates , 10 men with non-insulin-dependent diabetes mellitus ( NIDDM ) were fed an isoenergetic high-carbohydrate diet ( 55 % of energy as carbohydrate and 30 % as fat ) and a high-monounsaturated-fat diet ( 45 % of energy as fat and 40 % as carbohydrates ) for 6 wk in a r and omized , crossover manner . The high-carbohydrate diet raised fasting plasma triacylglycerol concentrations by 26 % ( P = 0.007 ) but did not affect postheparin lipoprotein lipase ( P = 0.2 ) or hepatic lipase activities ( P = 0.9 ) . The oral-fat-tolerance test labeled with retinyl palmitate also revealed no differences in postpr and ial plasma triacylglycerol ( P = 0.37 ) or retinyl palmitate clearances ( P = 0.34 ) between the two diets . We conclude that the increase in plasma triacylglycerol concentrations with high-carbohydrate diets in men with NIDDM is not due to reduced lipolysis or diminished postpr and ial clearance of triacylglycerol-rich lipoproteins but is primarily due to increased hepatic secretion of very-low-density-lipoprotein triacylglycerols
There is low to high ( majority moderate ) certainty for small improvements of unclear clinical importance in plasma glucose , triglycerides , and HDL concentrations favoring low-carbohydrate food at half of the prespecified time points .
There was little to no difference in LDL concentration or any of the secondary outcomes ( body weight , waist circumference , blood pressure , quality of life ) in response to either of the diets ( very-low- to high-certainty evidence ) .
Conclusions Currently available data provide low- to moderate-certainty evidence that dietary carbohydrate restriction to a maximum of 40 % yields slightly better metabolic control of uncertain clinical importance than reduction in fat to a maximum of 30 % in people with T2D .
Background It remains uncertain which diet is best for people with type 2 diabetes ( T2D ) .
Objective We compared the effects of dietary carbohydrate restriction with fat restriction on markers of metabolic syndrome and quality of life in people with T2D .