Effective weight loss was achieved in morbidly obese patients after undergoing  bariatric surgery .
A substantial majority of patients with diabetes , hyperlipidemia , hypertension , and obstructive sleep apnea experienced complete resolution or improvement
CONTEXT About 5 % of the US population is morbidly obese .
This disease remains largely refractory to diet and drug therapy , but generally responds well to bariatric surgery .
OBJECTIVE To determine the impact of bariatric surgery on weight loss , operative mortality outcome , and 4  obesity  comorbidities ( diabetes , hyperlipidemia , hypertension , and obstructive sleep apnea ) .
Gastric Bypass is an Effective Treatment for Obstructive Sleep Apnea in Patients with Clinically Significant Obesity
Background : We have demonstrated that obstructive sleep apnea ( OSA ) is prevalent in 60 % of patients undergoing bariatric surgery .  A study was conducted to determine whether weight loss following bariatric surgery ameliorates OSA . Methods : All 100 consecutive patients with symptoms of OSA were prospect ively evaluated by polysomnography before gastric bypass . Preoperative and postoperative scores of Epworth Sleepiness Scale ( ESS ) , Respiratory Disturbance Index ( RDI ) , and other parameters of sleep quality were compared using t-test . Results : Preoperative RDI was 40±4 ( normal 5 events/hour , n=100 ) . 13 patients had no OSA , 29 had mild OSA , while the remaining 58 patients were treated preoperatively for moderate-severe OSA . At a median of 6 months follow-up , BMI and ESS scores improved ( 38±1 vs 54±1 kg/m2 , 6±1 vs 12±0.1 , P<0.001 , postoperatively vs preoperatively ) . To date , 11 patients have completed postoperative polysomnography ( 3 - 21 months ) after losing weight ( BMI 40±2 vs 62±3 kg/m2 , P<0.001).There was significant improvement in ESS ( 3±1 vs 14±2 ) , minimum O2 saturation ( SpO2 86±2 vs 77±5 ) , sleep efficiency ( 85±2 % vs 65±5 % ) , all P<0.001 , postop vs preop ; and RDI ( 56±13 vs 23±7 , P=0.041 ) . Regression analysis demonstrated no correlation between preoperative BMI , ESS score and the severity of OSA ; and no correlation between % excess body weight loss and postoperative RDI . Conclusion : Weight loss following gastric bypass results in profound improvement in OSA . The severity of apnea can not be reliably predicted by preoperative BMI and ESS ; therefore , patients with symptoms of OSA should undergo polysomnography
Effective weight loss was achieved in morbidly obese patients after undergoing  bariatric surgery .
A substantial majority of patients with diabetes , hyperlipidemia , hypertension , and obstructive sleep apnea experienced complete resolution or improvement
CONTEXT About 5 % of the US population is morbidly obese .
This disease remains largely refractory to diet and drug therapy , but generally responds well to bariatric surgery .
OBJECTIVE To determine the impact of bariatric surgery on weight loss , operative mortality outcome , and 4  obesity  comorbidities ( diabetes , hyperlipidemia , hypertension , and obstructive sleep apnea ) .