Conclusions This systemic review shows that preoperative interventions can be beneficial in improving wound healing and scar formation .
In selected cases , wound healing was found to benefit from a higher preoperative body temperature , topical vitamin E application , and low patient stress levels .
Background Poor wound healing and scar formation  remain critical problems in daily surgical practice .
Generally , most attention is paid to intra- and postoperative interventions to improve wound healing after surgery , while preoperative interventions remain unsatisfactorily explored .
Objectives In this systematic review , the available literature on the beneficial effects of preoperative interventions on wound healing and scar formation have been summarized and compared .
Impact of preoperative anxiolytic on surgical site infection in patients undergoing abdominal hysterectomy.
BACKGROUND An increased anxiety may be associated with a higher risk of surgical site infection ( SSI ) , but there is little objective data on the effect of preoperative anxiolytic interventions on SSI . To address this issue , we evaluated the effects of preoperative diazepam on postoperative SSI  following abdominal hysterectomy . METHODS This r and omized , double-blinded , placebo-controlled study included 130 patients , American Society of Anesthesiologist physical status 1 or 2 . Patients were r and omly assigned to receive either oral diazepam 10 mg ( n = 65 ) or placebo ( n = 65 ) the night before and 1 hour prior to surgery . The assessment instruments were the Visual Analogue Scale and the State-Trait Anxiety Inventory . SSI was diagnosed according to the criteria of the Centers for Disease Control and Prevention with st and ard follow-up of 30 days . RESULTS The relative risk ( RR ) was 1.79 ( 95 % confidence interval [ CI ] : 1.31 - 2.43 ) , and the number of patients that needed to be treated was 5.2 ( 95 % CI : 2.74 - 50.76 ) to prevent 1 additional SSI . The RR for SSI in placebo-treated patients with high postoperative anxiety was 1.65 ( 95 % CI : 1.07 - 2.56 ) . CONCLUSION Diazepam-treated patients showed lower postoperative anxiety and lower incidence of SSI up to 30 days after surgery compared with placebo in patients undergoing abdominal hysterectomy
Conclusions This systemic review shows that preoperative interventions can be beneficial in improving wound healing and scar formation .
In selected cases , wound healing was found to benefit from a higher preoperative body temperature , topical vitamin E application , and low patient stress levels .
Background Poor wound healing and scar formation  remain critical problems in daily surgical practice .
Generally , most attention is paid to intra- and postoperative interventions to improve wound healing after surgery , while preoperative interventions remain unsatisfactorily explored .
Objectives In this systematic review , the available literature on the beneficial effects of preoperative interventions on wound healing and scar formation have been summarized and compared .