Exercise , particularly aerobic exercise , had a significant effect on serum leptin and a possible influence on adiponectin levels , suggesting its therapeutic implication
Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals ; however , results to date are controversial .
Here we performed a systematic review and meta- analysis of the available r and omized controlled trials ( RCTs ) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals .
Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study.
OBJECTIVE To investigate the effects of : I ) short- ( 8 weeks ) , II ) long-term ( 3 years ) weight loss , and III ) the degree of weight loss on circulating levels of adiponectin , high sensitive-C reactive protein ( hs-CRP ) , and fibrinogen in obese subjects . Moreover , to evaluate the effect of the lipase inhibitor , orlistat , on these parameters . DESIGN Weight loss induced in 93 obese subjects ( mean weight : 108.9+/-15.8 kg ) through  8-week very-low-energy diet ( VLED , 800 kcal/day ) followed by r and omization to orlistat or placebo together with lifestyle intervention for further 3 years . Adiponectin and hs-CRP were measured at baseline , after 8 weeks of VLED and 6 , 12 , and 36 months after the VLED by flowmetric xMAP technology ( Luminex Multi-Analyte Profiling System , Luminex Corp. , Austin , TX , USA ) . Fibrinogen was measured in a coagulation assay . RESULTS Weight loss after VLED treatment was 14.3+/-4.5 kg and after 3 years 7.7+/-8.7 kg . Orlistat-treated subjects regained 3.9 kg less than placebo-treated from the end of the VLED to 3 years ( P=0.01 ) . No differences were detected between the two groups regarding changes in adiponectin , hs-CRP , or fibrinogen . Accordingly , the groups were combined for further analyses . Serum adiponectin increased by 22 % ( P<0.05 ) after the VLED but returned to baseline after 3 years . Both short- and long-term weight losses needed to be in excess of 10 % ( approximately 12 kg ) in order to increase adiponectin levels significantly . Weight loss was associated with a significant decrease in hs-CRP . Fibrinogen decreased by 12 % ( P<0.05 ) after 3 years . CONCLUSIONS In obese subjects , weight loss was associated with an increase in serum adiponectin and a decrease in hs-CRP and plasma fibrinogen . Long-term weight loss ( 3 years ) must exceed 10 % to induce a combined significant improvement in these inflammatory markers
Exercise , particularly aerobic exercise , had a significant effect on serum leptin and a possible influence on adiponectin levels , suggesting its therapeutic implication
Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals ; however , results to date are controversial .
Here we performed a systematic review and meta- analysis of the available r and omized controlled trials ( RCTs ) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals .