: Probiotic supplementation reduces the risk of LOS in preterm infants
CONTEXT : Late-onset sepsis ( LOS ) is a major cause of mortality and morbidity in preterm infants .
Despite various preventive measures , its incidence continues to remain high , hence the urgent need for additional approaches .
One such potential strategy is supplementation with probiotics .
Currently there are > 30 r and omized controlled trials ( RCTs ) of probiotics in preterm infants that have reported on LOS .
Comparison of two empiric antibiotic regimen in late onset neonatal sepsis--a randomized controlled trial.
OBJECTIVE To compare the effectiveness of two antibiotic regimens among neonates with late onset sepsis ( LOS ) . METHODS This r and omized controlled trial conducted in a tertiary care teaching hospital , South India , included 90 babies with LOS . Detailed history , examination and appropriate investigations were done for all the babies . Cloxacillin + Amikacin were administered to 40 and Cefotaxime + Gentamicin to 50 babies . Outcomes including mortality , complications and treatment failure were evaluated . Chi-square test was used for categorical variables and Student 's unpaired t-test for continuous variables . RESULTS LOS had a male preponderance , and median time of onset was 13 days . Mortality was more among low birth weight babies irrespective of the antibiotics . Predominant bacteria isolated were coagulase-negative staphylococci ( 26.67 % ) , Escherichia coli ( 13.33 % ) and Streptococcus pneumoniae ( 13.33 % ) . Complications , mortality and cost were similar in both regimens . CONCLUSION There was no significant difference between the two antibiotic regimens with regard to outcome of LOS
: Probiotic supplementation reduces the risk of LOS in preterm infants
CONTEXT : Late-onset sepsis ( LOS ) is a major cause of mortality and morbidity in preterm infants .
Despite various preventive measures , its incidence continues to remain high , hence the urgent need for additional approaches .
One such potential strategy is supplementation with probiotics .
Currently there are > 30 r and omized controlled trials ( RCTs ) of probiotics in preterm infants that have reported on LOS .