In general , studies suggest that root canal sealers elicit mild to severe toxic effects and that several factors may influence biocompatibility , e.g. , material setting condition and time , material concentration , and type of exposure .
4 ) Conclusions : The available evidence shows that root canal sealers exhibit variable toxic potential at the cellular and tissue level .
However , the method ological heterogeneity among studies included in this systematic review and the somewhat conflicting results do not allow a conclusion on which type of sealer presents higher biocompatibility .
( 1 ) Aim : To perform a systematic review of the literature on the biocompatibility of  root canal sealers  that encompasses the various types of sealers that are commercially available as well as both in vitro and in vivo evidence . (
Evaluation of bone tissue response to a sealer containing mineral trioxide aggregate.
INTRODUCTION This study analyzed bone tissue reactions to MTA Fillapex ( Ângelus Industria de Produtos Odontológicos Ltda , Londrina , Brazil ) compared with an epoxy resin-based material in the femur of Wistar rats . METHODS Bone tissue reactions were evaluated in 15 animals after 7 , 30 , and 90 days ( n = 5 per period ) . Three surgical cavities were prepared on the femur and filled with 0.2 mL MTA Fillapex , AH Plus ( Dentsply DeTrey GmbH , Konstanz , Germany ) , or no sealer ( negative control ) . By the end of each experimental period , 5 animals were r and omly euthanized . The sample s were histologically processed and analyzed using a light microscope . The presence of inflammatory cells , fibers , and hard tissue barrier formation was evaluated . Differences among the groups and between the 3 experimental periods were evaluated by using 2-way analysis of variance followed by the Bonferroni post hoc test ( P ≤ .05 ) . RESULTS MTA Fillapex scored significantly higher for neutrophils at 7 days than at 90 . At 7 days , the same occurred when comparing MTA Fillapex with AH Plus . The presence of lymphocytes/plasmocytes significantly decreased over time in all groups . Macrophages , giant cells , eosinophils , and fiber condensation presented no differences among groups and periods . Within 90 days , all groups presented complete hard tissue barrier formation . CONCLUSIONS The presence of mineral trioxide aggregate in MTA Fillapex composition did not improve the bone tissue repair . The presence of sealers provided the re-establishment of the original bone tissue structure and the inflammatory response decreased over time , so they can be considered biocompatible
In general , studies suggest that root canal sealers elicit mild to severe toxic effects and that several factors may influence biocompatibility , e.g. , material setting condition and time , material concentration , and type of exposure .
4 ) Conclusions : The available evidence shows that root canal sealers exhibit variable toxic potential at the cellular and tissue level .
However , the method ological heterogeneity among studies included in this systematic review and the somewhat conflicting results do not allow a conclusion on which type of sealer presents higher biocompatibility .
( 1 ) Aim : To perform a systematic review of the literature on the biocompatibility of  root canal sealers  that encompasses the various types of sealers that are commercially available as well as both in vitro and in vivo evidence . (