The results show that , in particular , frequent cannabis use , especially daily use , and the consumption of high-potency cannabis are associated with a higher risk of developing psychosis .
Moreover , several genotypes moderate the impact of cannabis use on psychosis risk , particularly those involved in the dopamine function , such as AKT1 .
Finally , cannabis use is associated with an earlier psychosis onset and increased risk of transition in individuals at a clinical high risk of psychosis .
These findings indicate that changing cannabis use behavior could be a harm reduction strategy employed to lower the risk of developing psychosis .
Increasing evidence indicates a relationship between  cannabis use and psychosis risk .
Specific factors , such as determinants of cannabis use or the genetic profile of cannabis users , appear to moderate this association .
The present systematic review presents a detailed and up-to- date literature overview on factors that influence the relationship between cannabis use and psychosis risk .
Epidemiological analysis of alcohol and drug use as risk factors for psychotic experiences.
Clinical and laboratory studies link alcohol and other drug use to the occurrence of psychotic experiences , but epidemiologic evidence has been lacking . In this study , the quantitative relationships between alcohol or other drug use and psychotic experiences were examined by analysis of prospect i ve data from 4994 adult household residents sample d in a multisite survey of mental disorders in the population , the NIMH Epidemiologic Catchment Area Program . After control for sociodemographic factors and preexisting psychiatric conditions , the risk for onset of self-reported delusions or hallucinations was observed to be greater for daily users of marijuana or cocaine and for users of anxiolytics or sympathomimetics compared with nonusers . After control for daily cocaine use and alcohol disorder , the risk of onset of psychotic experiences for daily users of marijuana was double that for nonusers .  Alcohol disorder in men  was associated with eightfold risk and in women with threefold risk . Baseline depressive episodes , manic episodes , agoraphobia , and obsessive-compulsive disorder also were associated with increased risk of onset of psychotic experiences
The results show that , in particular , frequent cannabis use , especially daily use , and the consumption of high-potency cannabis are associated with a higher risk of developing psychosis .
Moreover , several genotypes moderate the impact of cannabis use on psychosis risk , particularly those involved in the dopamine function , such as AKT1 .
Finally , cannabis use is associated with an earlier psychosis onset and increased risk of transition in individuals at a clinical high risk of psychosis .
These findings indicate that changing cannabis use behavior could be a harm reduction strategy employed to lower the risk of developing psychosis .
Increasing evidence indicates a relationship between  cannabis use and psychosis risk .
Specific factors , such as determinants of cannabis use or the genetic profile of cannabis users , appear to moderate this association .
The present systematic review presents a detailed and up-to- date literature overview on factors that influence the relationship between cannabis use and psychosis risk .