In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
Reducing Consumption of Sugar-Sweetened Beverages Is Associated With Reduced Blood Pressure: A Prospective Study Among United States Adults
Background — Increased consumption of sugar-sweetened beverages ( SSBs ) has been associated with an elevated risk of obesity , metabolic syndrome , and type II diabetes mellitus . However , the effects of SSB consumption on blood pressure ( BP ) are uncertain . The objective of this study was to determine the relationship between changes in SSB consumption and changes in  BP among adults . Methods and Results — This was a prospect i ve analysis of 810 adults who participated in the PREMIER Study ( an 18-month behavioral intervention trial ) .  BP and dietary intake  ( by two 24-hour recalls ) were measured at baseline and at 6 and 18 months . Mixed-effects models were applied to estimate the changes in BP in responding to changes in SSB consumption . At baseline , mean SSB intake was 0.9±1.0 servings per day ( 10.5±11.9 fl oz/d ) , and mean systolic BP/diastolic BP was 134.9±9.6/84.8±4.2 mm Hg . After potential confounders were controlled for , a reduction in SSB of 1 serving per day was associated with a 1.8-mm Hg ( 95 % confidence interval , 1.2 to 2.4 ) reduction in systolic BP and 1.1-mm Hg ( 95 % confidence interval , 0.7 to 1.4 ) reduction in diastolic BP over 18 months . After additional adjustment for weight change over the same period , a reduction in SSB intake was still significantly associated with reductions in systolic and diastolic BPs  ( P<0.05 ) . Reduced intake of sugars was also significantly associated with reduced BP . No association was found for diet beverage consumption or caffeine intake and BP . These findings suggest that sugars may be the nutrients that contribute to the observed association between SSB and BP . Conclusions — Reduced consumption of SSB and sugars was significantly associated with reduced BP . Reducing SSB and sugar consumption may be an important dietary strategy to lower BP . Clinical Trial Registration — URL : http:// clinical trials.gov . Unique identifier : NCT00000616
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .