Results : We confirmed the importance of the 4 main factors influencing SC : ( 1 ) environmental factors , ( 2 ) genomic factors , ( 3 ) gene-environment interactions , and ( 4 ) evidence -based interventions .
The model demonstrates the complex network of factors influencing SC .
Background : Smoking behaviour is a major public health problem worldwide .
Several sources have confirmed the implication of genomic factors in smoking behaviour .
These factors interact both with environmental factors and interventions to develop a certain behaviour .
Objectives : Describing the environmental and genomic factors as well as the interventions influencing smoking cessation  ( SC ) and developing a working model incorporating the different factors influencing SC were our main objectives .
Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial.
This study examined the role of dopaminergic genes in prospect i ve smoking cessation and response to  bupropion treatment in a placebo-controlled clinical trial . Smokers of European ancestry ( N=418 ) provided blood sample s for genetic analysis and received either bupropion or placebo ( 10 weeks ) plus counseling . Assessment s included the dopamine D2 receptor ( DRD2 ) genotype , dopamine transporter ( SLC6A3 ) genotype , demographic factors , and nicotine dependence . Smoking status was verified at the end of treatment ( EOT ) and at 6-month follow-up . The results provided evidence for a significant DRD2 * SLC6A3 interaction effect on prolonged smoking abstinence and time to relapse at EOT , independent of treatment condition . Such effects were no longer significant at 6-month follow-up , however . These results provide the first evidence from a prospect i ve clinical trial that genes that alter dopamine function may influence smoking cessation and relapse during the treatment phase
Results : We confirmed the importance of the 4 main factors influencing SC : ( 1 ) environmental factors , ( 2 ) genomic factors , ( 3 ) gene-environment interactions , and ( 4 ) evidence -based interventions .
The model demonstrates the complex network of factors influencing SC .
Background : Smoking behaviour is a major public health problem worldwide .
Several sources have confirmed the implication of genomic factors in smoking behaviour .
These factors interact both with environmental factors and interventions to develop a certain behaviour .
Objectives : Describing the environmental and genomic factors as well as the interventions influencing smoking cessation  ( SC ) and developing a working model incorporating the different factors influencing SC were our main objectives .