The pooled estimate from the studies suggested that the addition of testosterone to HT regimens improved sexual function scores for postmenopausal women .
A significant adverse effect was a decrease in high-density lipoprotein ( HDL ) cholesterol levels .
However , there is evidence that adding testosterone to HT has a beneficial effect on sexual function in postmenopausal women .
There was a reduction in HDL cholesterol associated with the addition of testosterone to the HT regimens .
It is , therefore , difficult to estimate the effect of testosterone on sexual function in association with any individual hormone treatment regimen
BACKGROUND : The value of adding testosterone to hormone therapy ( HT ) for the management of peri- and postmenopausal women is controversial and has not been systematic ally review ed .
OBJECTIVES : To determine the benefits and risks of testosterone therapy for peri- and postmenopausal women taking hormone therapy .
The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis: a double-blind, randomized, placebo-controlled clinical trial.
METHODS In a r and omized , double-blind , placebo-controlled clinical trial , we evaluated the effect of a 2-year treatment with n and rolone decanoate ( ND ) on bone mineral density ( BMD ) of lumbar spine , femoral neck , and trochanter and on vertebral fracture rate , muscle mass , and hemoglobin levels .  Sixty-five osteoporotic women older than 70 years were studied . Thirty-two patients received injections of 50 mg ND , and 33 received placebos every 3 weeks . All patients received 500 mg calcium tablets daily . RESULTS Compared to baseline , ND increased the BMD of the lumbar spine ( 3.4 % + /- 6.0 and 3.7 % + /- 7.4 ; p < .05 ) and femoral neck ( 4.1 % + /- 7.3 and 4.7 % + /- 8.0 ; p < .05 ) after 1 and 2 years , respectively . The BMD of trochanter increased significantly only after the first year ( 4.8 % + /- 9.3 , p < .05 ) . Compared to the placebo group , the ND group presented with significantly increased BMD of the trochanter and neck . ND significantly reduced incidence of new vertebral fractures ( 21 % vs 43 % in the placebo group ; p < .05 ) . ND showed a significant statistical increase in lean body mass after the first ( 6.2 % + /- 5.8 ; p < .01 ) and second years ( 11.9 % + /- 29.2 ; p < .01 ) . In addition , a 2-year treatment with ND significantly increased hemoglobin levels compared to baseline ( 14.3 % ; p < .01 ) and placebo ( p < .01 ) . CONCLUSIONS ND increased BMD , hemoglobin levels , and muscle mass , and reduced the vertebral fracture rate of elderly osteoporotic women
The pooled estimate from the studies suggested that the addition of testosterone to HT regimens improved sexual function scores for postmenopausal women .
A significant adverse effect was a decrease in high-density lipoprotein ( HDL ) cholesterol levels .
However , there is evidence that adding testosterone to HT has a beneficial effect on sexual function in postmenopausal women .
There was a reduction in HDL cholesterol associated with the addition of testosterone to the HT regimens .
It is , therefore , difficult to estimate the effect of testosterone on sexual function in association with any individual hormone treatment regimen
BACKGROUND : The value of adding testosterone to hormone therapy ( HT ) for the management of peri- and postmenopausal women is controversial and has not been systematic ally review ed .
OBJECTIVES : To determine the benefits and risks of testosterone therapy for peri- and postmenopausal women taking hormone therapy .