RESULT ( S ) For infants , studies on psychomotor development showed no deficits , but few investigated cognitive or behavioral development .
Studies on toddlers generally reported normal cognitive , behavioral , socio-emotional , and psychomotor development .
For children in middle childhood , development seems comparable in children born after assisted reproduction and controls , although fewer studies have been conducted with follow-up to this age .
( S ) It may tentatively be concluded that the neurodevelopment of children born after  fertility treatment  is overall comparable to that in children born after spontaneous conception
OBJECTIVE To systematic ally review the existing literature on neurodevelopmental outcomes in children born after medically assisted reproduction  compared with those of children born after spontaneous conception .
Outcome in children from cryopreserved embryos.
A cohort of 91 children from cryopreserved embryos and 83 control children who were conceived normally had their development assessed using the Griffiths 's scales of mental development . The controls ( 81 singletons and two twins ) of a similar age , sex , and social class were selected from siblings , cousins , and peers of the  cryopreserved embryo group ( 68 singleton , 20 twins , and three triplets ) . Children from cryopreserved embryos had a lower mean birth weight and mean gestational age and a higher proportion were born by caesarean section .  One child from the cryopreserved embryo group had Down 's syndrome , three had squints , and four had conductive hearing loss while in the control children , six had squints , and nine had conductive hearing loss . In both groups , including the child with Down 's syndrome , the mean Griffiths 's quotient was greater than the st and ard 100 . In the children from cryopreserved embryos , the singleton and multiple birth subgroups had statistically similar assessment results . The mean ( SD ) Griffiths 's quotient was 105.69 ( 13.55 ) in children from cryopreserved embryos and 108.18 ( 9.80 ) in controls at a chronological age of 25.08 ( 12.86 ) and 29.19 ( 14.65 ) months respectively . Overall , the development in children from cryopreserved embryos did not cause concern though formal testing had highlighted small differences compared with other children conceived normally and of a similar social class
RESULT ( S ) For infants , studies on psychomotor development showed no deficits , but few investigated cognitive or behavioral development .
Studies on toddlers generally reported normal cognitive , behavioral , socio-emotional , and psychomotor development .
For children in middle childhood , development seems comparable in children born after assisted reproduction and controls , although fewer studies have been conducted with follow-up to this age .
( S ) It may tentatively be concluded that the neurodevelopment of children born after  fertility treatment  is overall comparable to that in children born after spontaneous conception
OBJECTIVE To systematic ally review the existing literature on neurodevelopmental outcomes in children born after medically assisted reproduction  compared with those of children born after spontaneous conception .