Benefits , harms , and costs Guideline implementation should result in a reduction of cost and related harm of administering antibiotics when not required and a reduction of infection and related morbidities when antibiotics have demonstrated a proven benefit .
Abstract Objective To review the evidence and provide recommendations on antibiotic prophylaxis for gynaecologic procedures .
Outcomes Outcomes evaluated include need and effectiveness of antibiotics to prevent infections in gynaecologic procedures .
Antimicrobial Prophylaxis in Laparotomic Gynecologic Surgery: a Prospective Randomized Study Comparing Amoxicillin-Clavulanic Acid with Cefazolin
Abstract A prospect i ve r and omized study was conducted at the Department of Obstetrics and Gynecology , University of Bari to compare two antimicrobial regimens , amoxicillin-clavulanic acid with cefazolin as ultra-short term prophylaxis in laparotomic gynecologic surgery . Patients were r and omly allocated to receive a single dose of amoxicillin-clavulanic acid ( 2.2 g ) [ Group A ] or cefazolin ( 2 g ) [ Group B ] 30 minutes before surgery . Each patient was assessed daily until discharge for fever and the presence of infection of the surgical wound , urinary tract and respiratory tract . In the amoxicillin-clavulanic acid ( Group A ) and cefazolin ( Group B ) groups , overall 258 and 253 patients , respectively were evaluable for prophylactic efficacy at hospital discharge . Infectious complications were infrequent in both arms . Febrile morbidity occurred in 16 ( 6.3 % ) and 21 ( 8.1 % ) patients respectively in the amoxicillinclavulanic acid and cefazolin groups . Wound infection and urinary tract infection were also higher but not significantly in the cefazolin group ( 0.8 % versus 0 % and 2.7 % versus 2.0 % respectively ) . There was no respiratory tract infection or septic death in either group . It is concluded that ultra-short term prophylaxis with both amoxicillin-clavulanic acid and cefazolin is safe and effective in elective laparotomic gynecologic surgery
Benefits , harms , and costs Guideline implementation should result in a reduction of cost and related harm of administering antibiotics when not required and a reduction of infection and related morbidities when antibiotics have demonstrated a proven benefit .
Abstract Objective To review the evidence and provide recommendations on antibiotic prophylaxis for gynaecologic procedures .
Outcomes Outcomes evaluated include need and effectiveness of antibiotics to prevent infections in gynaecologic procedures .