Conclusion This is the first study to demonstrate that a higher predictive IL-6 cut-off level should be determined for aging sarcopenia in men than in women
Background Aging sarcopenia characterized by low muscle mass with low muscle strength affects men and women differently .
The contribution of interleukin-6 ( IL-6 ) to sarcopenia has been suggested based on a negative correlation between plasma IL-6 and muscle function described by some studies .
However , no consensus regarding clinical ly relevant cut-off criteria has been reached .
Another question arises whether pooling male and female data is an accurate way to determine the predictive value of IL-6 in sarcopenia .
The present meta- analysis was design ed to assess : ( 1 ) whether plasma IL-6 in aged population s in fact correlates negatively to muscle strength ; ( 2 ) whether such a correlation exists both in men and in women ; and ( 3 ) whether plasma IL-6 shows a gender difference in old age .
Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects
Background : Inflammatory markers are increased in chronic obstructive pulmonary disease ( COPD ) and are hypothesised to play an important part in muscle dysfunction and exercise intolerance . Methods : The Health Aging and Body Composition ( Health ABC ) study is a prospect i ve observational cohort of well functioning individuals aged 70–79 years . A cross sectional analysis of the baseline data was conducted to examine the association between inflammatory markers and ventilatory limitation , muscle strength , and exercise capacity . These associations were compared in participants with and without obstructive lung disease ( OLD ) . Results : Of the 3075 participants enrolled in the Health ABC cohort , OLD was identified by spirometric testing in 268 participants and 2005 participants had normal spirometric results . Of the participants with OLD , 35 % , 38 % , and 27 % participants had mild , moderate , and severe OLD , respectively . Participants with OLD had lower quadriceps strength ( 102.5 Nm v 108.9 Nm , p = 0.02 ) , lower maximum inspiratory pressure ( 64.7 cm H2O v 74.2 cm H2O , p<0.0001 ) , higher systemic interleukin (IL)-6 levels ( 2.6 pg/ml v 2.2 pg/ml , p<0.0001 ) , and higher C-reactive protein ( CRP ) levels ( 3.5 mg/l v 2.5 mg/l , p<0.0001 ) than those with normal spirometry . In participants with OLD and those with normal spirometry , forced expiratory volume in 1 second ( FEV1 ) was associated with IL-6 ( adjusted regression coefficients ( β ) = −5.3 ( 95 % CI −9.1 to−1.5 ) and −3.1 ( 95 % CI −4.3 to −1.9 ) , respectively ) . IL-6 and TNF were also associated with quadriceps strength among participants with OLD and those with normal spirometry ( β = −6.4 ( 95 % CI −12.8 to −0.03 ) and −3.4 ( 95 % CI −5.4 to −1.3 ) , respectively , for IL-6 and β = −10.1 ( 95 % CI −18.7 to −1.5 ) and −3.8 ( 95 % CI −7 to −0.6 ) , respectively , for TNF ) . IL-6 , quadriceps strength , and maximum inspiratory pressures were independent predictors of reduced exercise capacity in both groups . Conclusions : In well functioning elderly subjects with or without OLD , IL-6 is associated with reduced FEV1 , quadriceps strength , and exercise capacity
Conclusion This is the first study to demonstrate that a higher predictive IL-6 cut-off level should be determined for aging sarcopenia in men than in women
Background Aging sarcopenia characterized by low muscle mass with low muscle strength affects men and women differently .
The contribution of interleukin-6 ( IL-6 ) to sarcopenia has been suggested based on a negative correlation between plasma IL-6 and muscle function described by some studies .
However , no consensus regarding clinical ly relevant cut-off criteria has been reached .
Another question arises whether pooling male and female data is an accurate way to determine the predictive value of IL-6 in sarcopenia .
The present meta- analysis was design ed to assess : ( 1 ) whether plasma IL-6 in aged population s in fact correlates negatively to muscle strength ; ( 2 ) whether such a correlation exists both in men and in women ; and ( 3 ) whether plasma IL-6 shows a gender difference in old age .