Our meta‐ analysis showed beneficial effects  of statin use  on reducing inflammatory markers in patients with MetS and related disorders
& NA ; Current evidence suggests that statin use decreases the incidence of cardiovascular diseases ( CVD ) through reducing LDL cholesterol and decreasing inflammation .
Metabolic syndrome ( MetS ) is usually associated with increased inflammatory markers and increased risk of CVD .
Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure.
BACKGROUND Heart failure has been associated with impaired endothelial function , increased inflammatory process and elevated oxidative stress status . Both statins and vitamin E separately improve endothelial function in patients with hypercholesterolemia and /or advanced atherosclerosis . AIM To evaluate the effect of atorvastatin alone or in combination with vitamin E on endothelial function and serum levels of interleukin-6 ( IL-6 ) , tumor necrosis factor alpha ( TNF-alpha ) and vascular cells adhesion molecule ( sVCAM-1 ) in patients with ischemic heart failure . METHODS Thirty-eight male patients with ischemic cardiomyopathy were r and omly divided into three groups and received either atorvastatin 10 mg/day ( n = 14 ) , a combination of atorvastatin 10 mg/day plus vitamin E 400 IU/day ( n = 12 ) , or no statin or antioxidant treatment ( n=12 , controls ) for 4 weeks . Forearm blood flow ( FBF ) was measured using venous occlusion strain-gauge plethysmography . Forearm vasodilatory response to reactive hyperemia ( RH% ) or to nitrate ( NTG% ) was defined as the percent change of FBF from rest to the maximum flow during reactive hyperemia or after nitrate administration , respectively . RESULTS RH% was significantly improved in both the atorvastatin-treated ( p < 0.01 ) and atorvastatin plus vitamin E groups ( p < 0.05 ) , but the increase was significantly higher in the atorvastatin-treated group ( p < 0.05 ) . Serum levels of IL-6 , TNF-alpha and sVCAM-1 were decreased in the atorvastatin-treated group ( p < 0.05 for all ) , but remained unaffected in the other two groups ( p = NS for all ) . CONCLUSIONS Low dose atorvastatin treatment improves endothelial function and reduces the expression of proinflammatory cytokines and adhesion molecules in patients with ischemic heart failure , an effect partly depressed by vitamin
Our meta‐ analysis showed beneficial effects  of statin use  on reducing inflammatory markers in patients with MetS and related disorders
& NA ; Current evidence suggests that statin use decreases the incidence of cardiovascular diseases ( CVD ) through reducing LDL cholesterol and decreasing inflammation .
Metabolic syndrome ( MetS ) is usually associated with increased inflammatory markers and increased risk of CVD .