It was concluded that sesame consumption can significantly reduce blood TAG levels but there is insufficient evidence to support its hypocholesterolaemic effects .
Increased plasma lipid profiles are among the most important risk factors of CHD and stroke .
Sesame contains considerable amounts of vitamin E , MUFA , fibre and lignans , which are thought to be associated with its plasma lipid-lowering properties .
Effect of Sesamin Supplementation on Cardiovascular Risk Factors in Women with Rheumatoid Arthritis
Objective : Rheumatoid arthritis ( RA ) is an inflammatory disease with increased mortality from cardiovascular disease ( CVD ) . Oxidative stress has a critical role in the pathogenesis of RA and CVD . Sesamin , the main lignin constituent of sesame , has several antioxidant and anti-inflammatory effects . This study aim ed to investigate the effects of sesamin supplementation on anthropometric indices , lipid profile , blood pressure , and oxidative stress markers in women with RA . Methods : In this r and omized , double-blind , placebo-controlled clinical trial , 44 patients with RA were r and omly divided into 2 groups ( intervention and control ) . Patients consumed 200 mg/day sesamin supplement and placebo in the intervention and control groups , respectively , for 6 weeks ( spring 2014 ) . At baseline and at the end of the study , anthropometric indices and blood pressure were assessed . Serum concentrations of lipid profile , malondialdehyde ( MDA ) , and total antioxidant capacity ( TAC ) were also determined . Results : At the end of study , sesamin supplementation significantly decreased serum levels of MDA ( p = 0.018 ) and increased TAC and high-density lipoprotein cholesterol ( HDL-C ) levels in patients with RA ( p = 0.020 and p = 0.007 , respectively ) . In the sesamin group , the mean of weight , body mass index , waist-to-hip ratio , body fat , systolic blood pressure , and the concentration of other lipid profiles ( triglycerides , total cholesterol , and low-density lipoprotein cholesterol [ LDL-C ] ) were also significantly decreased at the end of study compared to baseline values ( p < 0.05 ) . However , the difference between the 2 groups was not statistically significant in this regard ( p > 0.05 ) . Conclusion : Sesamin exhibited a protective effect on cardiovascular risk factors in patients with RA . However , further investigation is suggested
It was concluded that sesame consumption can significantly reduce blood TAG levels but there is insufficient evidence to support its hypocholesterolaemic effects .
Increased plasma lipid profiles are among the most important risk factors of CHD and stroke .
Sesame contains considerable amounts of vitamin E , MUFA , fibre and lignans , which are thought to be associated with its plasma lipid-lowering properties .