Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .
Effects of combination of zinc and vitamin A supplementation on serum fasting blood sugar, insulin, apoprotein B and apoprotein A-I in patients with type I diabetes
Background and aim There is accumulating evidence that shows the metabolism of zinc and vitamin A are altered in diabetes mellitus type I ( DMTI ) , thus the present study was conducted to evaluate the effects of combination of zinc and vitamin A supplementation on serum fasting blood sugar ( FBS ) , insulin , apoprotein B and apoprotein A-I in patients with DMTI . Design Forty-eight , 7-year-old to 20-year-old patients with at least 2 years of DMTI history , without any metabolic condition or medicine intake with insulin treatment , participated in a r and omized double-blind clinical trial for 12 weeks . They were divided into zinc and vitamin A (VAZ)-supplemented ( 10 mg elemental zinc per day and one-half of a 25,000 IU vitamin A tablet every other day ) and /or placebo groups after matching for sex , age and DMTI duration . Nutrient intake was estimated using 24 h recall and was analyzed by food processor program . Serum apoproteins B and A-I , FBS and insulin levels were determined at the beginning and end of the trial . Results There was significant increase in apoprotein A-I ( P < 0.0001 ) and a significant decrease in apoprotein B ( P < 0.0001 ) and apoprotein B/apoprotein A-I ratio ( P < 0.0001 ) at the end of the study compared with baseline values in the VAZ group but apoprotein A-I had a significant increase ( P < 0.0001 ) and the apoprotein B/apoprotein A-I ratio had a significant decrease ( P = 0.02 ) at the end of study in the VAZ group compared with the control group Conclusion It seems that combined zinc and vitamin A supplementation can improve serum apoprotein A-I , apoprotein B and the apoprotein B/apoprotein A-I ratio in patients with DMTI
Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .