The benefits of antioxidants or DHA/EPA supplementation for CF , although observed in some studies , are not consistent enough to recommend routine use of these supplements .
Antioxidant micronutrients and essential fatty acids supplementation intake appears to have a protective effect in some diseases such as cardiovascular disease , cancer , and asthma .
The aim of this study was to perform a systematic review to evaluate the effects of these nutrients on nutritional and clinical outcomes of patients with cystic fibrosis ( CF ) .
This is a systematic review of r and omized clinical trials ( RCTs ) in CF .
A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis.
Low plasma concentrations of docosahexaenoic acid ( DHA ) are reported in unsupplemented cystic fibrosis ( CF ) patients . Forty-one CF patients aged from 6 to 12 years were r and omized to receive high-dose DHA ( 100 mg/kg/day in the first month and 1 g per day thereafter through a 12-month supplementation ) or placebo ( germ oil ) . Primary outcome was percentage change in plasma AA : DHA ratio . Secondary outcomes were changes in the number of pulmonary exacerbations compared to previous year , lung function , BMI , skinfold thicknesses , and body composition assessed by DXA and in serum concentrations of C-reactive protein , cytokines and vitamin ( α-tocopherol and retinol ) . Compared to the control group plasma AA : DHA ratio decreased in the intervention group after 6 months ( median percentage changes : -73 % in the intervention group vs. -10 % in the control group , P=0.001 ) . No differences were detected between groups for secondary outcomes . Despite a decrease of the AA/DHA ratio  , DHA supplementation for one year did not induce any significant biochemical and clinical improvement in CF patients
The benefits of antioxidants or DHA/EPA supplementation for CF , although observed in some studies , are not consistent enough to recommend routine use of these supplements .
Antioxidant micronutrients and essential fatty acids supplementation intake appears to have a protective effect in some diseases such as cardiovascular disease , cancer , and asthma .
The aim of this study was to perform a systematic review to evaluate the effects of these nutrients on nutritional and clinical outcomes of patients with cystic fibrosis ( CF ) .
This is a systematic review of r and omized clinical trials ( RCTs ) in CF .