There were no overall effects from antioxidant vitamins , inositol or dietary minerals on psychiatric symptoms .
There is preliminary evidence that certain vitamin and mineral supplements may reduce psychiatric symptoms in some people with schizophrenia .
BACKGROUND When used as an adjunctive with antipsychotics , certain vitamins and minerals may be effective for improving symptomatic outcomes of schizophrenia , by restoring nutritional deficits , reducing oxidative stress , or modulating neurological pathways .
Vitamin E in the treatment of tardive dyskinesia: the possible involvement of free radical mechanisms.
One of the major problems associated with long-term neuroleptic treatment is persistent tardive dyskinesia ( TD ) , for which there is no satisfactory treatment . We have recently proposed that some cases of TD are associated with neuronal dysfunction result ing from excess free radical production occurring during catecholamine metabolism . We therefore decided to assess the efficacy of a powerful free radical scavenging agent , alpha-tocopherol ( vitamin E ) , on the clinical signs of TD . We treated 15 patients with persistent TD with alpha-tocopherol and matched placebo in a r and omized crossover design . Patients demonstrated a significant overall reduction in scores on the Abnormal Involuntary Movements Scale ( AIMS ) after treatment with alpha-tocopherol , but not after placebo . The mean reduction in the AIMS score with alpha-tocopherol was 43 percent , with seven patients showing a greater than 50 percent reduction in their dyskinesia . There was also a trend for a decrease in scores on the Brief Psychiatric Rating Scale , but no change was observed in scores on the Simpson-Angus Scale for Extrapyramidal Side Effects . Our findings are consistent with the possibility that alpha-tocopherol is beneficial in the treatment of some patients with TD , but further research is necessary to establish the efficacy of this agent
There were no overall effects from antioxidant vitamins , inositol or dietary minerals on psychiatric symptoms .
There is preliminary evidence that certain vitamin and mineral supplements may reduce psychiatric symptoms in some people with schizophrenia .
BACKGROUND When used as an adjunctive with antipsychotics , certain vitamins and minerals may be effective for improving symptomatic outcomes of schizophrenia , by restoring nutritional deficits , reducing oxidative stress , or modulating neurological pathways .