It can be classified according to their configuration , shape , content , and can be described specifically with an anatomical term . “
Rheumatoid arthritis is a chronic inflammatory disease characterized by the development of osseous and cartilaginous damage .
The correct differentiation between a true erosion and other entities — then often called “ pseudoerosions”—is essential to avoid misdiagnosing rheumatoid arthritis and to correctly interpret the progress of the disease .
The aims of this systematic review were as follows : to create a definition and delineation of the term “ pseudoerosion ” , to point out morphological pitfalls in the interpretation of images , and to report on difficulties arising from choosing different imaging modalities .
MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA)
Objective : To identify predictors of radiographic progression in a 2-year r and omised , double-blind , clinical study ( CIMESTRA ) of patients with early rheumatoid arthritis ( RA ) . Methods : Patients with early RA ( n = 130 ) were treated with methotrexate , intra-articular betamethasone and ciclosporin/placebo-ciclosporin . Baseline magnetic resonance imaging ( MRI ) of the wrist ( wrist-only group , n = 130 ) or  MRI  of  wrist and metacarpophalangeal ( MCP ) joints ( wrist+MCP group , n = 89 ) ( OMERACT RAMRIS ) ,  x-ray examination  of h and s , wrists and forefeet ( Sharp/van der Heijde Score ( TSS ) ) , Disease Activity Score ( DAS28 ) , anti-cyclic citrullinated peptide antibodies ( anti-CCP ) , HLA-DRB1-shared epitope ( SE ) and smoking status were assessed . Multiple regression analysis was performed with delta-TSS ( 0–2 years ) as dependent variable and baseline DAS28 , TSS , MRI bone oedema score , MRI synovitis score , MRI erosion score , anti-CCP , smoking , SE , age and gender as explanatory variables . Results : Baseline values : median DAS28 5.6 ( range 2.4–8.0 ) ; anti-CCP positive 61 % ; radiographic erosions 56 % . At 2 years : DAS28 2.0 ( 0.5–5.7 ) , in DAS remission : 56 % , radiographic progression 26 % ( wrist+MCP group , similar for wrist-only group ) . MRI bone oedema score was the only independent predictor of delta-TSS ( wrist+MCP group : coefficient = 0.75 ( 95 % CI 0.55 to 0.94 ) , p<0.001 ; wrist-only group : coefficient = 0.59 ( 95 % CI 0.40 to 0.77 ) , p<0.001 ) . Bone oedema score explained 41 % of the variation in the progression of TSS ( wrist+MCP group ) , 25 % in wrist-only group ( Pearson ’s r = 0.64 and r = 0.50 , respectively ) . Results were confirmed by sensitivity analyses . Conclusion : In a r and omised controlled trial aim ing at remission in patients with early RA , baseline RAMRIS MRI bone oedema score of MCP and wrist joints ( and of wrist only ) was the strongest independent predictor of radiographic progression in h and s , wrists and forefeet after 2 years . MRI synovitis score , MRI erosion score , DAS28 , anti-CCP , SE , smoking , age and gender were not independent risk factors . Trial registration number : NCT00209859
It can be classified according to their configuration , shape , content , and can be described specifically with an anatomical term . “
Rheumatoid arthritis is a chronic inflammatory disease characterized by the development of osseous and cartilaginous damage .
The correct differentiation between a true erosion and other entities — then often called “ pseudoerosions”—is essential to avoid misdiagnosing rheumatoid arthritis and to correctly interpret the progress of the disease .
The aims of this systematic review were as follows : to create a definition and delineation of the term “ pseudoerosion ” , to point out morphological pitfalls in the interpretation of images , and to report on difficulties arising from choosing different imaging modalities .