However , subgroup analyses for the estrogen dose and the progestin type in relation to changes in SHBG levels did show significant differences : COCs containing second generation progestins and /or the lower estrogen doses ( 20–25 µg EE ) were found to have less impact on SHBG concentrations .
The current literature review and meta- analysis demonstrates that COCs decrease circulating levels of total T and free T and increase SBHG concentrations .
Due to the SHBG increase , free T levels decrease twice as much as total T. The estrogen dose and progestin type of the COC do not influence the decline of total and free T , but both affect SHBG .
BACKGROUND Combined oral contraceptives ( COCs ) reduce levels of and rogen , especially testosterone ( T ) , by inhibiting ovarian and adrenal and rogen synthesis and by increasing levels of sex hormone-binding globulin ( SHBG ) .
Although this suppressive effect has been investigated by numerous studies over many years , to our knowledge no systematic review concerning this issue had been performed .
Desogestrel+ethinylestradiol versus levonorgestrel+ethinylestradiol. Which one has better affect on acne, hirsutism, and weight change.
OBJECTIVE To compare complications of third and second generation oral contraceptive pills ( OCPs ) . METHODS In a r and omized clinical trial from October 2007 to October 2008 , 100 healthy women of reproductive age referred to Amir Hospital Family Planning Clinic and some heath centers in Semnan , Iran were r and omized in 2 equal groups . They received either a third generation OCP ( 150 microgram desogestrel [ DSG ] + 30 microgram ethinylestradiol [ EE ] ) or a second generation type ( 150 microgram levonorgestrel [ LNG ] + 30 microgram EE ) . Six months later , changes of weight , acne , and hirsutism severity , as well as serum titers of sex hormone-binding globulin ( SHBG ) and free testosterone were compared between the 2 groups . RESULTS Forty-five women were evaluated in the DSG+EE OCP group , and 46 women in the LNG+EE OCP group . The BMI was significantly higher in the second group ( p=0.000 ) after 6 months duration . Likewise , the decrement of acne and hirsutism severity was significantly higher in the DSG+EE users ( p=0.000 ) . Mean changes of serum free testosterone ( p=0.967 ) and SHBG ( p=0.916 ) were comparable between the 2 groups . CONCLUSION In comparison with the LNG+EE OCP , the DSG+EE OCP is a contraceptive pill that significantly decreases the severity of acne and hirsutism , without any significant change in weight
However , subgroup analyses for the estrogen dose and the progestin type in relation to changes in SHBG levels did show significant differences : COCs containing second generation progestins and /or the lower estrogen doses ( 20–25 µg EE ) were found to have less impact on SHBG concentrations .
The current literature review and meta- analysis demonstrates that COCs decrease circulating levels of total T and free T and increase SBHG concentrations .
Due to the SHBG increase , free T levels decrease twice as much as total T. The estrogen dose and progestin type of the COC do not influence the decline of total and free T , but both affect SHBG .
BACKGROUND Combined oral contraceptives ( COCs ) reduce levels of and rogen , especially testosterone ( T ) , by inhibiting ovarian and adrenal and rogen synthesis and by increasing levels of sex hormone-binding globulin ( SHBG ) .
Although this suppressive effect has been investigated by numerous studies over many years , to our knowledge no systematic review concerning this issue had been performed .