Age of study population and year of publication modified the relationship between testosterone and CVD .
Results were largely confirmed by separate analyses of free- and bioavailable testosterone .
The systematic review displayed no association between endogenous testosterone and risk for CVD in middle-aged men .
In elderly men , testosterone may weakly protect against CVD .
Alternatively , low testosterone may indicate a poor general health
CONTEXT The literature provides no clear answer as to whether low endogenous testosterone increases risk of cardiovascular disease ( CVD ) in healthy men .
OBJECTIVE Our purpose was to estimate the predictive value of testosterone for CVD and to identify study features explaining conflicting results .
Progression in intima media thickness—the significance of hormonal biomarkers of chronic stress
OBJECTIVE The pathophysiological pathways from stress caused by psychosocial stress to IHD has not been dealt with very extensively . The objective of this study was to analyse the association between cortisol levels and progression in intima media thickness ( IMT ) . METHODS AND RESULTS In 1998 and 2002 , 95 participants went through a clinical investigation including ultrasound of the artery carotis communis .  Progression in IMT was analysed in relation to levels of salivary cortisol in 1998 and the average levels of salivary cortisol in 1998/2002 . Further , the significance of conventional coronary risk factors , testosterone and dehydro-epi and rosterone sulphate ( DHEAS ) were evaluated . Among the men , only age and HDL-cholesterol ( negative ) were significantly correlated with progression in IMT . Among the women , awakening cortisol response was significantly correlated with progression in IMT . Testosterone and DHEAS were borderline significantly associated ( negatively ) with progression in IMT in both genders . CONCLUSION Progression in atherosclerosis were determined by different risk factors in women and men . The awakening cortisol response was of great importance to IMT progression in women but not in men
Age of study population and year of publication modified the relationship between testosterone and CVD .
Results were largely confirmed by separate analyses of free- and bioavailable testosterone .
The systematic review displayed no association between endogenous testosterone and risk for CVD in middle-aged men .
In elderly men , testosterone may weakly protect against CVD .
Alternatively , low testosterone may indicate a poor general health
CONTEXT The literature provides no clear answer as to whether low endogenous testosterone increases risk of cardiovascular disease ( CVD ) in healthy men .
OBJECTIVE Our purpose was to estimate the predictive value of testosterone for CVD and to identify study features explaining conflicting results .