Individual patient ’s behaviors , lack of social support , clinical or treatment and illness-related , and health system factors influenced psychotropic medication non-adherence .
Conclusion Psychotropic medication non-adherence was high .
It was influenced by various factors operating at different levels .
Background Major psychiatric disorders are growing public health concern that attributed 14 % of the global burden of diseases .
The management of major psychiatric disorders is challenging mainly due to medication non-adherence .
However , there is a paucity of summarized evidence on the prevalence of psychotropic medication non-adherence and associated factors .
Therefore , we aim ed to summarize existing primary studies ’ finding to determine the pooled prevalence and factors associated with psychotropic medication non-adherence .
Nonadherence to medication four years after a first episode of psychosis and associated risk factors.
OBJECTIVES This study examined concurrent associations and predictors at first indication of nonadherence to antipsychotic medication four years after a first episode of psychosis . METHODS A prospect i ve cohort of 171 patients in urban Irel and with a first episode of psychosis was followed up four years after inception ( follow-up primary analysis , N=84 ; secondary analysis , N=104 ) . RESULTS At the four-year follow-up 76 % were adherent and 24 % were not . Nonadherence was concurrently associated with substance misuse ( p<.01 ) , increased symptomatology ( p<.01 ) , less insight ( p=.01 ) , lower global functioning ( p<.01 ) , and negative attitudes toward medication ( p<.01 ) . Compared with other patients , those who were nonadherent had more readmissions ( p=.01 ) . Predictors of future nonadherence were substance misuse ( p=.02 ) and duration of untreated psychosis ( p=.04 ) . CONCLUSIONS This prospect i ve investigation confirms previous cross-sectional studies . The association between longer duration of untreated psychosis and nonadherence warrants further research because it could be interpreted as further evidence of the importance of early intervention
Individual patient ’s behaviors , lack of social support , clinical or treatment and illness-related , and health system factors influenced psychotropic medication non-adherence .
Conclusion Psychotropic medication non-adherence was high .
It was influenced by various factors operating at different levels .
Background Major psychiatric disorders are growing public health concern that attributed 14 % of the global burden of diseases .
The management of major psychiatric disorders is challenging mainly due to medication non-adherence .
However , there is a paucity of summarized evidence on the prevalence of psychotropic medication non-adherence and associated factors .
Therefore , we aim ed to summarize existing primary studies ’ finding to determine the pooled prevalence and factors associated with psychotropic medication non-adherence .