Conclusions Large r and omized controlled trials of at least 6 months duration with carbohydrate restriction appear superior in improving lipid markers when compared with low-fat diets .
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk .
Objective A systematic review and meta-analyses were conducted to compare the effects of very low , low , and moderate carbohydrate , higher fat diets versus high-carbohydrate , low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults .
Plasma Oxidized Low-Density Lipoprotein, a Strong Predictor for Acute Coronary Heart Disease Events in Apparently Healthy, Middle-Aged Men From the General Population
Background —Oxidized LDL ( oxLDL ) is thought to play a key role in the inflammatory response in the arterial vessel wall . Methods and Results —In a prospect i ve , nested , case-control study , the association between plasma oxLDL and risk of an  acute coronary heart disease ( CHD ) event was investigated in men without prevalent CHD or diabetes mellitus at baseline . Subjects came from 2 population -based MONICA/KORA Augsburg surveys conducted in the years 1989–1990 and 1994–1995 with follow-up in 1998 ( mean±SD follow-up time , 5.6±2.6 years ) .  OxLDL was determined by ELISA in 88 men with incident CHD and in 258 age- and survey-matched controls .  Hazard ratios ( HRs ) were estimated from conditional logistic-regression models with matching for age and survey . Baseline mean plasma oxLDL concentrations were significantly higher in subjects who subsequently experienced an event compared with controls ( mean±SD , 110±32 versus 93±28 U/L ; P≤0.001 ) . After adjustment for smoking , hypertension , obesity , physical activity , education , and alcohol consumption , the HR for a future CHD event in a comparison of the upper tertile of the oxLDL distribution with the lower tertile was 4.25 ( 95 % confidence interval , 2.09 to 8.63 ; P<0.001 ) . Plasma oxLDL was the strongest predictor of CHD events compared with a conventional lipoprotein profile and other traditional risk factors for CHD . When both oxLDL and C-reactive protein were simultaneously assessed in the same model , they still predicted future CHD events even after multivariable adjustment . Conclusions —Elevated concentrations of oxLDL are predictive of future CHD events in apparently healthy men . Thus , oxLDL may represent a promising risk marker for clinical CHD complications and should be evaluated in further studies
Conclusions Large r and omized controlled trials of at least 6 months duration with carbohydrate restriction appear superior in improving lipid markers when compared with low-fat diets .
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk .
Objective A systematic review and meta-analyses were conducted to compare the effects of very low , low , and moderate carbohydrate , higher fat diets versus high-carbohydrate , low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults .