Using the Cochrane methodology , and as measures of effect size mean difference and Hedge 's g , SRIs proved to be superior to drug placebo , with a modest effect size .
From direct comparisons of CBT and SRI treatments , we conclude that CBT has the superior efficacy .
COMBO versus CBT shows that SRI treatment adds little to concomitant CBT , while COMBO shows favourable outcome versus SRI alone .
In pre-trial partial treatment responders , those who failed a SRI had better outcome from adding CBT as compared to continuing a SRI .
Those who failed CBT treatment did as well with continued CBT as with switching to a SRI .
Serotonin reuptake inhibiting drugs ( SRI ) have been used in the treatment of paediatric obsessive-compulsive disorder over the past 30 years .
Behavior therapy versus clomipramine for the treatment of obsessive-compulsive disorder in children and adolescents.
OBJECTIVE To compare , via a pilot study , the effectiveness of behavior therapy and of drug treatment in children and adolescents with obsessive-compulsive disorder . METHOD Twenty-two children aged between 8 and 18 years were r and omly assigned to behavior therapy ( n = 12 ) or open clomipramine ( n = 10 ) in a parallel design lasting 12 weeks . Behavior therapy included exposure and response prevention administered in weekly sessions . The mean dosage of clomipramine was 2.5 mg/kg ( range = 1.4 - 3.3 mg/kg ) . The main outcome variables were the Children 's Yale-Brown Obsessive Compulsive Scale ( CY-BOCS ) and the Leyton Obsessional Inventory-Child Version ( LOI-CV ) . RESULTS Significant improvement was obtained in both treatment conditions . Behavior therapy produced stronger therapeutic changes than clomipramine on the CY-BOCS ( p < .05 ) , whereas on the LOI-CV no significant differences between the results of the two treatments were found . Five of the nine initial nonresponders showed significant changes after extension of treatment for another 12 weeks . CONCLUSION Behavior therapy is shown to be a good alternative for drug treatment and deserves further study in larger sample s of children with obsessive-compulsive disorder
Using the Cochrane methodology , and as measures of effect size mean difference and Hedge 's g , SRIs proved to be superior to drug placebo , with a modest effect size .
From direct comparisons of CBT and SRI treatments , we conclude that CBT has the superior efficacy .
COMBO versus CBT shows that SRI treatment adds little to concomitant CBT , while COMBO shows favourable outcome versus SRI alone .
In pre-trial partial treatment responders , those who failed a SRI had better outcome from adding CBT as compared to continuing a SRI .
Those who failed CBT treatment did as well with continued CBT as with switching to a SRI .
Serotonin reuptake inhibiting drugs ( SRI ) have been used in the treatment of paediatric obsessive-compulsive disorder over the past 30 years .