Conclusion Our study demonstrates potential beneficial effects of probiotics on inflammation , uremic toxins , and GI Symptoms in ESRD patients .
Background / Objectives We performed this systematic review and meta- analysis to evaluate effects of probiotics on inflammation , uremic toxins , and gastrointestinal ( GI ) symptoms in end-stage renal disease ( ESRD ) patients .
Effect of a symbiotic gel (Lactobacillus acidophilus + Bifidobacterium lactis + inulin) on presence and severity of gastrointestinal symptoms in hemodialysis patients.
OBJECTIVE The study aim ed to assess the effect of a symbiotic gel on presence and severity of gastrointestinal symptoms ( GIS ) in hemodialysis patients . DESIGN A double-blinded , placebo-controlled , r and omized , clinical trial was design ed . The study was conducted at 2 public hospitals in Guadalajara , Mexico . SUBJECTS AND INTERVENTION Twenty-two patients were r and omized to the intervention group ( nutritional counseling + symbiotic gel )  and 20 patients were r and omized to the control group ( nutritional counseling + placebo )  , during 2 months of follow-up . MAIN OUTCOME MEASURE Presence and monthly episodes of GIS were assessed by direct interview and severity by using the self-administered GIS question naire . Additionally , biochemical parameters , inflammatory markers , and nutritional status ( dietary intake , subjective global assessment , anthropometry , and body composition ) were evaluated . RESULTS After a 2-month treatment , intervention group had a significant reduction in prevalence and monthly episodes of vomit , heartburn , and stomachache , as well as a significant decrease in GIS severity compared with control group . Moreover , intervention group had a greater yet not significant decrease in the prevalence of malnutrition and a trend to reduce their C-reactive protein and tumor necrosis factor α levels compared with control group . No symbiotic-related adverse side effects were shown in these patients . Clinical studies with longer follow-up and sample size are needed to confirm these results . CONCLUSIONS We concluded that administration of a symbiotic gel is a safe and simple way to improve common GIS in dialysis patients
Conclusion Our study demonstrates potential beneficial effects of probiotics on inflammation , uremic toxins , and GI Symptoms in ESRD patients .
Background / Objectives We performed this systematic review and meta- analysis to evaluate effects of probiotics on inflammation , uremic toxins , and gastrointestinal ( GI ) symptoms in end-stage renal disease ( ESRD ) patients .