The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation .
Conclusion : This meta- analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels
ABSTRACT Objective : The aim of this systematic review and meta- analysis was to determine and clarify the impact of curcuminoids on  serum lipid levels .
Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals.
SCOPE Curcuminoids are poorly bioavailable , but potentially lipid- and inflammation-lowering phytochemicals . We hypothesized that curcuminoids , when administered as a micellar formulation with hundredfold enhanced bioavailability , decrease blood lipids and inflammation in subjects with moderately elevated cholesterol and C-reactive protein concentrations . METHODS AND RESULTS We carried out a r and omized , double-blind , crossover study ( 4-wk washout phase ) with 42 subjects consuming 294 mg curcuminoids per day ( as micelles ) or placebo for 6 wk . At the beginning , after 3 wk and at the end ( 6 wk ) of each intervention , we collected fasting blood sample s to determine curcuminoids , blood lipids , and markers of inflammation , glucose and iron homeostasis , and liver toxicity . Daily ingestion of 98 mg micellar curcuminoids with each principal meal for as little as 3 wk result ed in fasting curcuminoid plasma concentrations of 49 nmol/L. Neither blood lipids , nor markers of inflammation , glucose and iron homeostasis , or liver enzymes differed between curcuminoid and placebo interventions . CONCLUSION Consumption of 98 mg of highly bioavailable curcuminoids with each principal meal sufficed to achieve curcuminoid accumulation in the blood , was safe , and did not alter blood lipids , inflammation , glucose , or iron homeostasis in healthy subjects with slightly elevated blood cholesterol and C-reactive protein
The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation .
Conclusion : This meta- analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels
ABSTRACT Objective : The aim of this systematic review and meta- analysis was to determine and clarify the impact of curcuminoids on  serum lipid levels .