Over 2 months of treatment , SSRIs are no more efficacious than placebo in patients with migraine .
In patients with chronic TTH , SSRIs are less efficacious than tricyclic antidepressants .
In comparison with SSRIs , the burden of adverse events in patients receiving tricyclics was greater .
BACKGROUND Headache is a common medical problem .
In view of recent discoveries about the role of serotonin in pain mechanisms , selective serotonin re-uptake inhibitors ( SSRIs ) have been evaluated for the prevention of  migraine and tension-type headaches ( TTH ) .
OBJECTIVES To evaluate the efficacy and tolerability of SSRIs for preventing migraine and TTH .
The economic burden of headache: an epidemiological study in the Republic of San Marino.
SYNOPSIS We examined the socio-economic consequences of headache in a r and om sample of 514 working people living inthe Republic of San Marino . Our results show that , in the preceding year , 255 out of 514 ( 49.6 % ) suffered fromheadache ; 31.9 % ( 164/514 ) reported decreased efficiency as a consequence of headache ; 9.3 % ( 48/514 ) reportedthat head pain is always severe ; 7.4 % ( 38/514 ) were absent from work because of headache for a total of 338working days lost ; 8.4 % of all working days lost to illness were due to headache . We estimated that in the Republic of San Marino ( 21,792 inhabitants ) , headache causes a loss of at least 5,000working days every year . Since the cost of a working day in the Republic of San Marino is about 100,000 italianlire , the economic burden in this area amounts to 500 millions of lire in a year . This shows that headache is amajor socio-medical problem
Over 2 months of treatment , SSRIs are no more efficacious than placebo in patients with migraine .
In patients with chronic TTH , SSRIs are less efficacious than tricyclic antidepressants .
In comparison with SSRIs , the burden of adverse events in patients receiving tricyclics was greater .
BACKGROUND Headache is a common medical problem .
In view of recent discoveries about the role of serotonin in pain mechanisms , selective serotonin re-uptake inhibitors ( SSRIs ) have been evaluated for the prevention of  migraine and tension-type headaches ( TTH ) .
OBJECTIVES To evaluate the efficacy and tolerability of SSRIs for preventing migraine and TTH .