Data concerning effects of aspartame on main metabolic variables associated to diabetes and obesity do not support a beneficial related to its consumption
ABSTRACT Data about harms or benefits associated with the consumption of aspartame , a nonnutritive sweetener worldwide consumed , are still controversial .
This systematic review and meta- analysis of r and omized controlled clinical trials aim ed to assess the effect of aspartame consumption on  metabolic parameters related to diabetes and obesity .
The neuropsychiatric effects of aspartame in normal volunteers.
Ten healthy volunteers with no history of aspartame intolerance ( 6 men and 4 women , aged 21 - 36 years ) received a single dose of aspartame ( 15 mg/kg body weight in capsules ) or matching placebo in a r and omized , double-blind crossover study . Eleven blood sample s collected over 24 hours were analyzed for plasma glucose and amino acid concentrations . The following variables were evaluated at 1 , 2 , 4 , 8 , and 24 hours post-dosage : changes in mood measured on visual analog scales , cognitive function determined by digit-symbol substitution test ( DSST ) and arithmetic test scores , and reaction time measured with a brake-pedal reaction timer . Memory was tested at 2 and 24 hours after dosage based on recall of st and ardized 16-item word lists . No significant differences between aspartame and placebo were found in measures of sedation , hunger , headache , reaction-time , cognition , or memory at any time during the study . Plasma phenylalanine levels were significantly higher following aspartame ( P less than .01 ) than with placebo between 1 and 6 hours postdosage , reaching a maximum difference of + 3.36 mumols/dl at 2 hours . Plasma glucose concentrations were not significantly different between aspartame and placebo . The results of this study suggest that following a single 15 mg/kg dose of aspartame , no detectable effects are observed in a group of healthy volunteers with no history of aspartame intolerance , despite significant increases in plasma phenylalanine concentrations
Data concerning effects of aspartame on main metabolic variables associated to diabetes and obesity do not support a beneficial related to its consumption
ABSTRACT Data about harms or benefits associated with the consumption of aspartame , a nonnutritive sweetener worldwide consumed , are still controversial .
This systematic review and meta- analysis of r and omized controlled clinical trials aim ed to assess the effect of aspartame consumption on  metabolic parameters related to diabetes and obesity .