GH therapy can increase short-term growth and improve ( near ) final height .
Increases in height are such that treated individuals remain relatively short when compared with peers of normal stature .
BACKGROUND Idiopathic short stature ( ISS ) refers to children who are very short compared with their peers for unknown or hereditary reasons .
Recombinant human growth hormone ( GH ) has been used to increase growth and final height in children with ISS .
OBJECTIVES To assess the effects of recombinant human GH on short-term growth and final height in children with ISS .
Combined treatment with growth hormone and luteinizing hormone releasing hormone-analogue (LHRHa) of pubertal children with familial short stature
We evaluated the 12 month growth of 18 pubertal children with familial short stature r and omly assigned to clinical follow-up ( group A ) , GH treatment alone ( group B ) and GH+LHRH analogue ( LHRHa ) treatment ( group C ) . Height velocity increased significantly compared to baseline in groups A and B ( 4.7±0.4 vs 6.6±0.6 and 4.4±0.3 vs 8±1 respectively ) , but not in C ( 5±0.5 vs 6.5±0.4 ) . Moreover in group B height and height prognosis st and ard deviation score SDS ) also were higher ( −2.2±0.2 vs−1.7±0.2 and 1.8±0.3 vs −1±0.2 , respectively ) . Comparisons among the groups showed a significant increase in group B vs the other groups of height velocity SDS ( 3.9±1.3 vs 0.4 + 1 and 0.3±0.7 ) and of height prognosis SDS ( −1±0.2 vs −2.4±0.3 and −2.4±0.3 ) . In conclusion , after one-year treatment , GH seems to be more effective in stimulating growth  than GH±LHRHa , even if studies of longer duration and /or follow-up are needed
GH therapy can increase short-term growth and improve ( near ) final height .
Increases in height are such that treated individuals remain relatively short when compared with peers of normal stature .
BACKGROUND Idiopathic short stature ( ISS ) refers to children who are very short compared with their peers for unknown or hereditary reasons .
Recombinant human growth hormone ( GH ) has been used to increase growth and final height in children with ISS .
OBJECTIVES To assess the effects of recombinant human GH on short-term growth and final height in children with ISS .