There is a lack of robust evidence to assess the strength of other treatment options
Objectives Sarcopenia , defined as an age-associated loss of skeletal muscle function and muscle mass , occurs in approximately 6 - 22 % of older adults .
This paper presents evidence -based clinical practice guidelines for screening , diagnosis and management of sarcopenia from the task force of the International Conference on Sarcopenia and Frailty Research ( ICSFR ) .
Accuracy of segmental multi-frequency bioelectrical impedance analysis for assessing whole-body and appendicular fat mass and lean soft tissue mass in frail women aged 75 years and older
BACKGROUND / OBJECTIVE : We aim ed to examine the accuracy of segmental multi-frequency bioelectrical impedance analysis ( SMF-BIA ) for the assessment of whole-body and appendicular fat mass ( FM ) and lean soft tissue mass ( LM ) in frail older women , using dual-energy X-ray absorptiometry ( DXA ) as a reference method .SUBJECTS/ METHODS : All 129 community-dwelling Japanese frail older women with a mean age of 80.9 years ( range , 75–89 years ) from the Frailty Intervention Trial were recruited . The agreements between SMF-BIA and DXA for whole-body and appendicular body composition were assessed using simple linear regression and Bl and –Altman analysis . RESULTS : High coefficients of determination ( R2 ) for whole-body FM ( R2=0.94 , s.e . of estimate (SEE)=1.2 kg ) , whole-body LM ( R2=0.85 , SEE=1.4 kg ) , and appendicular FM ( R2=0.82 , SEE=1.1 kg ) were observed between SMF-BIA and DXA . The R2 coefficient for appendicular LM was moderate ( R2=0.76 , SEE=0.8 kg ) . Bl and –Altman plots demonstrated that there was systematic ( constant ) bias ( that is , DXA minus SMF-BIA ) with overestimation of whole-body FM ( bias=−1.2 kg , 95 % confidence interval (CI)=−1.5 to −0.1 ) and underestimation of whole-body LM ( bias=2.1 kg , 95 % CI=1.8–2.3 ) by SMF-BIA . Similar , the appendicular measurements also demonstrated systematic bias with overestimation of appendicular FM ( bias=−0.3 kg , 95 % CI=−0.5 to −0.1 ) and underestimation of whole-body LM ( bias=1.5 kg , 95 % CI=1.4–1.7 ) by SMF-BIA . In addition , the individual level accuracy demonstrated a non-proportional bias for whole-body LM ( r=0.08 , P=0.338 ) and appendicular FM ( r=0.07 , P=0.413 ) . CONCLUSIONS : SMF-BIA had acceptable accuracy for the estimation of whole-body and appendicular FM and LM in frail older women , although SMF-BIA underestimated LM and overestimated FM relative to DXA
There is a lack of robust evidence to assess the strength of other treatment options
Objectives Sarcopenia , defined as an age-associated loss of skeletal muscle function and muscle mass , occurs in approximately 6 - 22 % of older adults .
This paper presents evidence -based clinical practice guidelines for screening , diagnosis and management of sarcopenia from the task force of the International Conference on Sarcopenia and Frailty Research ( ICSFR ) .