Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Changes in daily leptin, ghrelin and adiponectin profiles following a diet with carbohydrates eaten at dinner in obese subjects.
BACKGROUND AND AIMS Our recently published r and omised clinical trial evaluated the effect of a low-calorie diet with carbohydrates eaten at dinner . This dietary pattern led to lower hunger scores , and better anthropometric , biochemical and inflammatory outcomes compared to a st and ard low-calorie diet . In the same study , changes in diurnal secretion patterns of leptin , ghrelin and adiponectin were investigated . METHODS AND RESULTS Seventy-eight police officers ( body mass index ( BMI ) > 30 ) were r and omly allocated to experimental ( carbohydrates at dinner ) or control weight loss diets for 6 months . Sixty-three subjects finished the programme . On days 0 , 7 , 90 and 180 blood sample s and hunger scores were collected every 4 h from 8:00 to 20:00 . Hormonal profiles were available for 39 . The dietary manipulation led to changes in daylight hormonal profiles in the experimental group . Leptin 's secretion curve became convex , with a nadir later in the day ( significant difference compared to baseline at morning and evening , p = 0.023 , p = 0.021 , respectively ) . Ghrelin 's secretion curve became concave , peaking only in the evening hours . Adiponectin 's curve was elevated only after the experimental diet ( significant difference compared to baseline at afternoon , p = 0.044 ) . CONCLUSIONS We propose that a low-calorie diet with carbohydrates eaten at dinner can modulate daytime hormonal profiles . Taken together with our earlier results , we believe this diet regime may prevent mid-day hunger , better support weight loss and improve metabolic outcomes compared to conventional weight loss diets . The trial is registered at controlled-trials.com , IS RCT N37829376 , December 2009
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .