Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Vitamin D3 increases in abdominal subcutaneous fat tissue after supplementation with vitamin D3.
OBJECTIVE The objective was to assess the amount of vitamin D3 stored in adipose tissue after long-term supplementation with high dose vitamin D3 . DESIGN A cross-sectional study on 29 subjects with impaired glucose tolerance who had participated in a r and omized controlled trial with vitamin D3 20 000 IU ( 500 μg ) per week vs placebo for 3 - 5 years . METHODS Abdominal subcutaneous fat tissue was obtained by needle biopsy for the measurements of vitamin D3 and 25-hydroxyvitamin D3 ( 25(OH)D3 ) . Body fat was measured with dual-energy X-ray absorptiometry , and serum 25(OH)D3 level was quantified . RESULTS In the subjects given vitamin D3 , the median concentrations of serum 25(OH)D3 , fat vitamin D3 , and fat 25(OH)D3 were 99 nmol/l , 209 ng/g , and 3.8 ng/g , respectively ; and correspondingly in the placebo group 62 nmol/l , 32 ng/g , and 2.5 ng/g . If assuming an equal amount of vitamin D3 stored in all adipose tissue in the body , the median body store was 6.6 mg vitamin D3 and 0.12 mg 25(OH)D3 in those given vitamin D3 . CONCLUSIONS Subcutaneous adipose tissue may store large amounts of vitamin D3 . The clinical importance of this storage needs to be determined
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .