This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
The Impact of Vitamin D Supplementation on Post-Partum Glucose Tolerance and Insulin Resistance in Gestational Diabetes: A Randomized Controlled Trial
Background Hypovitaminosis D has been associated with the development of gestational diabetes mellitus ( GDM ) in many observational studies . Objectives We report the first study of the impact of prenatal vitamin D supplementation on postpartum dysglycemia in GDM patients in a r and omized clinical trial . Patients and Methods Women with GDM at 12 - 32 weeks of gestation were assigned r and omly to either the intervention group ( in which serum 25-hydroxy vitamin D [ 25OHD ] levels were measured immediately , n = 48 ) or the control group ( in which the serum was stored and assayed at 6 - 12 weeks post-partum , n = 48 ) . Participants with initial serum 25OHD < 30 ng/mL in the intervention group were instructed to take a total of 700,000 IU vitamin D3 during pregnancy . The primary outcomes were fasting plasma glucose ( FPG ) , insulin , 2-h post 75 g glucose load plasma glucose ( 2-hPLG ) , homeostasis model assessment of insulin resistance ( HOMA-IR ) , HbA1C , and 25 OHD at 6 - 12 weeks after delivery . Results The mean ± SD of serum 25OHD in the intervention group raised dramatically from 14.6 ± 6.3 to 32.4 ± 14.4 ng/mL , whereas no significant change occurred in the control group ( from 17.7 ± 6.1 to 19.3 ± 9.6 ng/mL , P < 0.001 ) . Thirteen participants developed dysglycemia in each group . Mean FPG , 2-hPLG , and HOMA-IR were not significantly different between the groups . There was no significant difference between the groups for maternal and neonatal outcomes . Conclusions Although the high vitamin D supplementation dose in the present study ( compared to the 400 IU/day dose usually recommended for pregnancy ) safely increases the serum 25OHD , in GDM cases , the higher dose does not affect the plasma glucose level or insulin resistance at short term follow-up after delivery
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .