SBP-lowering effects were significantly increased for bisoprolol compared with placebo .
In conclusion , current evidence does not support carvedilol or bisoprolol as first-line therapy for adult hypertension without compelling indications
Although beta blockers have been used as initial therapy for ischemic heart diseases and heart failure , the beneficial effects of beta blockers are controversial compared with other antihypertensive agents as initial therapy for hypertension without compelling indications .
Moreover , atenolol has been most commonly used with beta blockers .
The objective of the present systematic review associated with the Japanese Society of Hypertension ( JSH ) 2019 Hypertension Guideline ( Clinical Question 6 ) was to assess the outcomes ( cardiocerebrovascular mortality , total cause mortality , hypotension , bradycardia , other adverse effects , and changes in systolic blood pressure ( SBP ) ) of currently used carvedilol and bisoprolol as initial therapy for adult hypertension without compelling indications .
Bisoprolol and hypertension: effects on sexual functioning in men.
OBJECTIVES To investigate prospect ively the effects of the selective beta 1 adrenoceptor blocker bisoprolol on sexuality of men with hypertension . DESIGN In newly diagnosed patients ( group I ) : double-blind , crossover , placebo controlled . In men with hypertension on antihypertensive treatment ( group II ) : crossover design . SETTING Large area in and around Rotterdam , The Netherl and s. PATIENTS Twenty-six men ( criteria : between 25 and 70 ; no disease etc . known to affect sexual functioning ) were recruited through their general practitioners . Group I ( n = 13 ) fulfilled the selection criteria , sitting blood pressure systolic > or = 160 mm Hg and /or diastolic > or = 95 mm Hg , measured on 3 different days . Group II ( n = 13 ) patients already on antihypertensive treatment .  MAIN OUTCOME MEASURES Data on blood pressure . Qualitative and quantitative data on sexuality through question naires , including personal and sexual history , sexual functioning , sexual satisfaction and erectile difficulties . RESULTS Bisoprolol is an effective antihypertensive drug with no detrimental effects on sexuality in newly diagnosed men with hypertension . In men already on antihypertensive medication bisoprolol improved sexuality in some parameters , i.e. firmness of erection during coitus , contentedness with sexual functioning and satisfaction with own sexuality . CONCLUSION Bisoprolol is an effective antihypertensive agent with no sexual side effects
SBP-lowering effects were significantly increased for bisoprolol compared with placebo .
In conclusion , current evidence does not support carvedilol or bisoprolol as first-line therapy for adult hypertension without compelling indications
Although beta blockers have been used as initial therapy for ischemic heart diseases and heart failure , the beneficial effects of beta blockers are controversial compared with other antihypertensive agents as initial therapy for hypertension without compelling indications .
Moreover , atenolol has been most commonly used with beta blockers .
The objective of the present systematic review associated with the Japanese Society of Hypertension ( JSH ) 2019 Hypertension Guideline ( Clinical Question 6 ) was to assess the outcomes ( cardiocerebrovascular mortality , total cause mortality , hypotension , bradycardia , other adverse effects , and changes in systolic blood pressure ( SBP ) ) of currently used carvedilol and bisoprolol as initial therapy for adult hypertension without compelling indications .