In general , active non-invasive anaesthetic methods seemed to provide favourable results compared to placebo or no anaesthesia , and topical anaesthetic drugs and PSF seemed to result in a better pain reduction than skin cooling .
However , the current evidence is insufficient to provide recommendations for daily clinical practice .
Future studies should also evaluate sex differences in pain perception , have uniformity with regard to vali date d pain measurement scales and address clinical ly significant differences in pain reduction besides statistically significant differences
Pain is a common side-effect of dermatological laser procedures .
Non-invasive anaesthetic drugs and anaesthetic procedures can be used to provide pain relief and increase patient satisfaction and treatment efficacy .
However , it remains unclear which method provides the best pain relief .
The objective of this systematic review was therefore to assess the efficacy and safety of non-invasive anaesthetic methods during dermatological laser procedures .
Treatment of leg telangiectasia by using a long-pulse dye laser at 595 nm with and without dynamic cooling device.
BACKGROUND AND OBJECTIVE The long-pulse dye laser ( PDL ) at 595 nm and pulse duration of 1.5 msec has been shown to improve clearance of larger vessels such as those seen in leg telangiectasia . The objectives of this study are twofold . First , to determine the effect of the dynamic cooling device ( DCD ) in clearance of leg telangiectasia by using a long-pulse PDL at 595 nm . Next , to determine the effect of the DCD in reducing transient discomfort associated with treatment and in reducing epidermal damage ( blistering , hyper/hypopigmentation , scarring ) caused by the laser . STUDY DESIGN / MATERIAL S AND METHODS Matched treatment sites were compared at energy densities of 20 and 24 J/cm(2 ) with and without the use of the cryogen spray  in 18 patients . In areas treated without the DCD , the laser pulse was delivered through a single layer of Spenco Second Skin . Patients received two treatments 6 weeks apart . Discomfort ratings , clearance of leg telangiectasia , and complications were assessed at 6 weeks , 12 weeks , and 6 months . RESULTS A reduction in discomfort ratings was found in most patients using the DCD . Six-month follow-up data revealed at the 20 J/cm(2 ) treatment sites , with or without the DCD , 76.9 % showed greater than 50 % clearance . At the 24 J/cm(2 ) treatment sites , with or without the DCD , 84.6 % showed greater than 50 % clearance . CONCLUSION The long-pulse dye laser at 595 nm with a 1.5-msec pulse duration cleared leg telangiectasia an average of 67.5 % with two treatments at 6 months . The major effect of the DCD was on pain reduction . There was no difference in clearance rates when using the DCD vs. cooled Second Skin . Further studies with longer cooling times with the DCD are needed to optimize treatment parameters
In general , active non-invasive anaesthetic methods seemed to provide favourable results compared to placebo or no anaesthesia , and topical anaesthetic drugs and PSF seemed to result in a better pain reduction than skin cooling .
However , the current evidence is insufficient to provide recommendations for daily clinical practice .
Future studies should also evaluate sex differences in pain perception , have uniformity with regard to vali date d pain measurement scales and address clinical ly significant differences in pain reduction besides statistically significant differences
Pain is a common side-effect of dermatological laser procedures .
Non-invasive anaesthetic drugs and anaesthetic procedures can be used to provide pain relief and increase patient satisfaction and treatment efficacy .
However , it remains unclear which method provides the best pain relief .
The objective of this systematic review was therefore to assess the efficacy and safety of non-invasive anaesthetic methods during dermatological laser procedures .