In conclusion , it was shown that very high fructose intake ( > 100 g/d ) increases serum LDL-C and TC concentrations .
Fructose is widely used as a sweetener in the production of many foods , yet the relation between fructose intake and cholesterol remains uncertain .
In this study , we performed a systematic review and meta- analysis of human , controlled , feeding trials involving isocaloric fructose exchange for other carbohydrates to quantify the effects of fructose on serum total cholesterol ( TC ) , LDL cholesterol ( LDL-C ) , and  HDL cholesterol ( HDL-C ) in adult humans .
The Effects of Physiologic Amounts of Simple Sugars on Lipoprotein, Glucose, and Insulin Levels in Normal Subjects
Using a crossover design , eight healthy volunteers r and omly received physiologic amounts ( ⅓ of each subject 's total carbohydrate intake ) of either fructose or sucrose as the primary source of simple sugar , incorporated into isocaloric diets comprised of typical American foods . After 7 and 14 days of consuming either of the two sugars , no change occurred in fasting glucose or insulin levels . In addition , total triglyceride , totalcholesterol , low-density-lipoprotein ( LDL ) cholesterol , and high-density-lipoprotein ( HDL ) cholesterol concentrations were unaltered . Since our study used conventional foods in normal eating patterns rather than contrived formulas or excessive amounts of simple sugar , our data indicate that there is no difference between sucrose or fructose on various lipid components or glucose and fasting insulin levels in the “ real world ” innormal subjects
In conclusion , it was shown that very high fructose intake ( > 100 g/d ) increases serum LDL-C and TC concentrations .
Fructose is widely used as a sweetener in the production of many foods , yet the relation between fructose intake and cholesterol remains uncertain .
In this study , we performed a systematic review and meta- analysis of human , controlled , feeding trials involving isocaloric fructose exchange for other carbohydrates to quantify the effects of fructose on serum total cholesterol ( TC ) , LDL cholesterol ( LDL-C ) , and  HDL cholesterol ( HDL-C ) in adult humans .