Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .
A Canadian multicentre placebo-controlled study of a fixed dose of brofaromine, a reversible selective MAO-A inhibitor, in the treatment of major depression.
In a 6-week double-blind study , 220 patients with major depression ( mostly out patients ) were r and omly assigned to receive a fixed dose of brofaromine 150 mg daily ( n = 111 ) or placebo ( n = 109 ) after a 1-week single-blind placebo washout . Except for the HAM-D sleep items , brofaromine was superior to placebo on measures of depression as determined by the four methods of assessing drug efficacy : ( 1 ) psychiatric symptom rating ( HAM-D 17-item less the three sleep items ) ; ( 2 ) self-rating scale ( Beck Depression Inventory ) ; ( 3 ) Clinical Global Assessment of Efficacy ; and ( 4 ) drop-out rate due to lack of efficacy . Most commonly reported adverse events with brofaromine were : headache , nausea , dizziness and sleep disturbance .  Brofaromine was found to be an effective antidepressant , superior to placebo with a good tolerability profile
Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .