Moreover , subgroup analyses suggested that the effects of glycemic control were significantly influenced by the sex of the subjects and the type and the method of intake of ITF .
Conclusions Our analyses confirmed that these four main glycemic indicators were significantly reduced by ITF supplementation , particularly in the prediabetes and T2DM population .
Evidence supports that reasonable administration of ITF supplementation may have potential clinical value as an adjuvant therapy for prediabetes and T2DM management .
Background Currently , many clinical trials have shown that inulin-type fructans ( ITF ) supplementation is associated with glycemic control ; nevertheless , the results are inconclusive .
The aim of this meta- analysis of r and omized controlled trials was to assess the effects of ITF supplementation on glycemic control .
A Randomised Crossover Trial: The Effect of Inulin on Glucose Homeostasis in Subtypes of Prediabetes
Background : Fermentable carbohydrates ( FCHO ) have been shown to improve insulin sensitivity in normoglycaemic and insulin-resistant subjects . However , there are no data on subjects with prediabetes . We aim ed to investigate the effect of the FCHO inulin , on glucose homeostasis in subjects with prediabetes . Methods : In a double-blind and placebo-controlled crossover study , 40 volunteers with prediabetes were r and omly allocated to take 30 g/day of inulin or cellulose for 2 weeks in a crossover trial , following a 4-week dose-escalation run-in . Fasting insulin and glucose were measured for all subjects . Fifteen of the 40 subjects also underwent a meal tolerance test to assess insulin sensitivity , free fatty acids and glucagon-like peptide-1 concentrations . A sub analysis was carried out to examine any differences between the prediabetes subtypes . Results : Inulin was associated with a significant increase in ( 0 - 30 min)incremental AUC ( iAUC ) for insulin ( treatment : p < 0.04 ) and ( 0 - 60 min)iAUC for insulin ( treatment : p < 0.04 ) compared to control . There was a significant reduction in insulin resistance measured by the homeostatic model assessment in the isolated-impaired fasting glucose ( p < 0.05 ) but not in the isolated-impaired glucose tolerance groups ( p = 0.59 ) . Conclusion : The FCHO , inulin , may have unique metabolic effects that are of particular benefit to people at risk of diabetes , which warrant further investigation
Moreover , subgroup analyses suggested that the effects of glycemic control were significantly influenced by the sex of the subjects and the type and the method of intake of ITF .
Conclusions Our analyses confirmed that these four main glycemic indicators were significantly reduced by ITF supplementation , particularly in the prediabetes and T2DM population .
Evidence supports that reasonable administration of ITF supplementation may have potential clinical value as an adjuvant therapy for prediabetes and T2DM management .
Background Currently , many clinical trials have shown that inulin-type fructans ( ITF ) supplementation is associated with glycemic control ; nevertheless , the results are inconclusive .
The aim of this meta- analysis of r and omized controlled trials was to assess the effects of ITF supplementation on glycemic control .