( S ) Few studies of medical therapies for endometriosis report outcomes that are relevant to patients , and many women gain only limited or intermittent benefit from treatment
OBJECTIVE To assess patient response rates to medical therapies used to treat endometriosis-associated pain .
Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis--a randomized, double-blind, multicenter, controlled trial.
OBJECTIVE To compare the efficacy and safety of dienogest ( DNG ) with intranasal buserelin acetate ( BA ) in patients with endometriosis . DESIGN Phase III , r and omized , double-blind , multicenter , controlled trial . SETTING Twenty-four study centers in Japan . PATIENT(S ) Two hundred seventy-one patients with endometriosis . INTERVENTION(S ) Dienogest ( 2 mg/day , orally ) or BA ( 900 microg/day , intranasally ) for 24 weeks . MAIN OUTCOME MEASURE(S ) The pre- to posttreatment changes in the scores of five subjective symptoms during nonmenstruation ( lower abdominal pain , lumbago , defecation pain , dyspareunia , and pain on internal examination ) and two objective findings ( in duration in the pouch of Douglas and limited uterine mobility ) . RESULT ( S ) Dienogest reduced the scores of all symptoms and findings at the end of treatment , and the mean changes in the scores of all symptoms and findings except in duration in the pouch of Douglas were comparable to those obtained with BA . Compared with BA , DNG was associated with irregular genital bleeding more frequently and with fewer hot flushes . The reduction in bone mineral density ( BMD ) during DNG treatment was significantly lower than that during BA treatment . CONCLUSION ( S ) DNG is as effective as intranasal BA in alleviating endometriosis , and causes less BMD loss
( S ) Few studies of medical therapies for endometriosis report outcomes that are relevant to patients , and many women gain only limited or intermittent benefit from treatment
OBJECTIVE To assess patient response rates to medical therapies used to treat endometriosis-associated pain .