RESULTS No statistical significant difference in bond strength between both categories was observed in caries-affected dentin at immediate evaluation and in sound dentin after ageing .
Etch- and -rinse adhesives , however , performed better in sound enamel and dentin substrates considering immediate bond strength .
None study assessed the long-term adhesive effectiveness to sound or demineralized enamel .
Although the articles included in this meta- analysis showed high heterogeneity and high risk of bias , the in vitro literature suggests superior performance of etch- and -rinse adhesives in primary teeth in comparison with self-etch systems
AIM To systematic ally review the literature for in vitro studies that evaluated the immediate or after ageing bond strength of  etch- and -rinse and self-etch adhesive systems to enamel and dentin of primary teeth .
Effect of cariogenic challenge on bond strength of adhesive systems to sound and demineralized primary and permanent enamel.
PURPOSE To evaluate the effect of cariogenic challenge on the bond strength of adhesive systems to sound and artificially demineralized enamel of primary and permanent teeth . MATERIAL S AND METHODS Eighty molars ( 40 primary , 40 permanent ) were r and omly assigned to 16 groups ( n = 5 ) according to the type of tooth ( primary [ PRIM ] or permanent [ PERM ] ) , enamel condition ( sound [ S ] or demineralized [ DEM ] ) , treatment after the restorative procedure ( control [ C ] or cariogenic challenge [ pH ] ) , and adhesive system  ( Adper Single Bond [ SB ] or Clearfil SE Bond [ SE ] ) . Teeth from the DEM group were subjected to cariogenic challenge by pH cycling prior to restorative procedures and pH group specimens were subjected to cariogenic challenge before the microshear test . One of two adhesive systems was applied to the flat enamel surfaces and composite cylinders ( 0.45 mm2 ) were built . The microshear bond test was performed . The data ( MPa ) were subjected to ANOVA and Tukey 's test ( α = 0.05 ) . RESULTS No statistically significant differences were detected between the adhesive systems . The S groups exhibited higher bond strength values than the DEM groups , as did C groups compared to pH groups . PERM groups also had higher bond strength values than PRIM groups , excluding PRIM S and PERM S , which had similar values . CONCLUSION The bond strength to demineralized enamel of primary teeth was lower than to the demineralized enamel of permanent teeth . Cariogenic challenge negatively influenced enamel bond strength , regardless of the type of tooth and adhesive system
RESULTS No statistical significant difference in bond strength between both categories was observed in caries-affected dentin at immediate evaluation and in sound dentin after ageing .
Etch- and -rinse adhesives , however , performed better in sound enamel and dentin substrates considering immediate bond strength .
None study assessed the long-term adhesive effectiveness to sound or demineralized enamel .
Although the articles included in this meta- analysis showed high heterogeneity and high risk of bias , the in vitro literature suggests superior performance of etch- and -rinse adhesives in primary teeth in comparison with self-etch systems
AIM To systematic ally review the literature for in vitro studies that evaluated the immediate or after ageing bond strength of  etch- and -rinse and self-etch adhesive systems to enamel and dentin of primary teeth .