This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .
Fat Mass and Obesity-Associated Gene (FTO) Is Linked to Higher Plasma Levels of the Hunger Hormone Ghrelin and Lower Serum Levels of the Satiety Hormone Leptin in Older Adults
The mechanisms through which common polymorphisms in the fat mass and obesity-associated gene ( FTO ) drive the development of obesity in humans are poorly understood . Using cross-sectional data from 985 older people ( 50 % females ) who participated at age 70 years in the Prospect i ve Investigation of the Vasculature in Uppsala Seniors ( PIVUS ) , circulating levels of ghrelin and leptin were measured after an overnight fast . In addition , subjects were genotyped for FTO rs17817449 ( AA , n = 345 [ 35 % ] ; AC/CA , n = 481 [ 48.8 % ] ; CC , n = 159 [ 16.1 % ] ) . Linear regression analyses controlling for sex , self-reported physical activity level , fasting plasma glucose , and BMI were used . A positive relationship between the number of FTO C risk alleles and plasma ghrelin levels was found ( P = 0.005 ; relative plasma ghrelin difference between CC and AA carriers = ∼9 % ) . In contrast , serum levels of the satiety-enhancing hormone leptin were inversely linked to the number of FTO C risk alleles ( P = 0.001 ; relative serum leptin difference between CC and AA carriers = ∼11 % ) . These associations were also found when controlling for waist circumference . The present findings suggest that FTO may facilitate weight gain in humans by shifting the endocrine balance from the satiety hormone leptin toward the hunger-promoting hormone ghrelin
This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .