Findings related to effectiveness ( treatment discontinuation , quality of life , and neurocognitive improvements ) were generally consistent with those observed in non-Chinese population s. No new safety signals specific for Chinese population s were raised for olanzapine .
Chinese and non-Chinese population s with schizophrenia or bipolar disorder treated with olanzapine display broadly similar responses .
BACKGROUND Despite the burden of schizophrenia and bipolar disorder in the Chinese population , country-specific data to guide practitioners regarding antipsychotic therapy are lacking .
TNF-α −308 G>A polymorphism and weight gain in patients with schizophrenia under long-term clozapine, risperidone or olanzapine treatment
Atypical or second-generation antipsychotics ( SGAs ) are associated with excessive body weight gain ( BWG ) and other components of metabolic syndrome . Among all SGAs , clozapine and olanzapine are known to cause the most significant weight gain , followed by risperidone and quetiapine . The genetic variant of tumor necrosis factor α ( TNF-α ) , -308 G > A polymorphism ( rs1800629 ) , has been implicated in clozapine-induced BWG in several studies . We hypothesized that TNF-α -308 G > A polymorphism has a general effect on SGA-induced BWG . The present study was conducted to examine the association between TNF-α -308 G > A polymorphism and BWG during treatment for schizophrenia using a variety of second generation antipsychotics ( SGAs ) . A total of 500 patients with schizophrenia treated with clozapine ( n=275 ) , olanzapine ( n=79 ) or risperidone ( n=146 ) for an average of 49.9 months were recruited . Subjects with an increase in weight of more than 7 % from the baseline before the current SGA treatment to the weight at the survey point were defined as having BWG . The association between TNF-α -308 G > A polymorphism and BWG was studied , and the effect of non-genetic factors such as baseline BMI , SGA treatment duration and SGA type on the association was controlled by logistic regression . The results revealed that there was no significant association between BWG and TNF-α -308 G > A polymorphism ( GG/GA/AA or GG/GA+AA ) in each separate SGA group or collectively . These findings suggest that TNF-α -308 G > A polymorphism does not play a major role in SGA-induced weight gain
Findings related to effectiveness ( treatment discontinuation , quality of life , and neurocognitive improvements ) were generally consistent with those observed in non-Chinese population s. No new safety signals specific for Chinese population s were raised for olanzapine .
Chinese and non-Chinese population s with schizophrenia or bipolar disorder treated with olanzapine display broadly similar responses .
BACKGROUND Despite the burden of schizophrenia and bipolar disorder in the Chinese population , country-specific data to guide practitioners regarding antipsychotic therapy are lacking .