There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain .
Non-steroidal anti-inflammatory drugs ( NSAIDs ) are medications that are frequently used by athletes .
There may also be some abuse of these substances , although it is unclear whether NSAIDs in fact enhance performance .
We performed a systematic review and meta- analysis to evaluate the effect of NSAIDs on sport performance indices .
Indomethacin does not influence natural cell-mediated cytotoxic response to endurance exercise.
Natural cell-mediated cytotoxicity ( NCMC ) has been shown to be attenuated during recovery from high-intensity or prolonged exercise . Two theories have been proposed to explain the transient suppression of NCMC : prostagl and in-induced inhibition of natural killer ( NK ) cell activity or a numerical redistribution of NK cells . This study was design ed to examine the effects of oral indomethacin ( a prostagl and in inhibitor ) on NCMC before and after 1 h of high-intensity running ( 85 % maximal oxygen uptake ) . A secondary purpose was to compare whole blood and isolated peripheral blood mononuclear cell assay procedures for assessing NCMC . Ten male distance runners completed two trials that were preceded by either 48 h of indomethacin ( Indo ; 150 mg/day ) or no treatment ( control ) . NK ( CD3(-)/CD16(+)/CD56(+ ) ) cell concentrations were significantly elevated postexercise but were not affected by Indo . NCMC was significantly suppressed at 1.5 h of recovery relative to preexercise only with the whole blood assay procedure . Indo was not found to influence NCMC , leukocyte , or lymphocyte subset concentrations . Mean cytotoxic response was significantly greater with the whole blood method
There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain .
Non-steroidal anti-inflammatory drugs ( NSAIDs ) are medications that are frequently used by athletes .
There may also be some abuse of these substances , although it is unclear whether NSAIDs in fact enhance performance .
We performed a systematic review and meta- analysis to evaluate the effect of NSAIDs on sport performance indices .