RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .
Effect of telmisartan 80 mg once daily on 24-h blood pressure profile in patients with mild-to-moderate hypertension failing to respond to prior antihypertensive therapy.
Blood pressure is not adequately controlled in almost 50 % of patients with hypertension who are in receipt of antihypertensive therapy . This multicentre , prospect i ve , open-label trial was design ed to determine whether or not once-daily telmisartan 80 mg reduced blood pressure during the last 6 h of the 24-h dosing interval in patients with mild-to-moderate hypertension who were unresponsive to previous antihypertensive therapy . The study comprised 100 patients ( 47 males , 53 females ) who had failed to respond satisfactorily to prior treatment given for a minimum of 3 months . At screening ,  24-h ambulatory blood pressure monitoring ( ABPM )  was conducted after the patient had been treated with the currently prescribed antihypertensive medication . Following 5 weeks of telmisartan 80 mg treatment , ABPM was repeated . Telmisartan significantly reduced mean systolic blood pressure , diastolic blood pressure ( DBP ) and pulse pressure compared with previous antihypertensive therapy over each time interval ( 24-h , morning , night-time and the last 6 h of the dosing interval [ 2.00 a.m.-8.00 a.m. ] ) analysed . In addition , more than 90 % of patients responded successfully ( clinic DBP < 90 mmHg or a > 10 mmHg reduction in clinic DBP ) at the end of telmisartan treatment . In conclusion , telmisartan provides effective blood pressure control throughout the 24-h dosing interval in patients with mild-to-moderate hypertension who were unresponsive to previous antihypertensive medication
RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .