Conclusions The use of sedatives and hypnotics and antidepressants including tricyclic antidepressants , selective serotonin reuptake inhibitors , and serotonin norepinephrine reuptake inhibitors appears to be related with an increased risk of falls .
It is not clear if the use of antihypertensive medications is associated with the risk of falls in older people
Purpose Falls are an important public health problem in older people .
Medication use is considered a risk factor for falls .
This study systematic ally review ed recent studies to determine the medications that might be associated with the risk of falling in older people .
Randomized, placebo-controlled trial of the cognitive effect, safety, and tolerability of oral extended-release oxybutynin in cognitively impaired nursing home residents with urge urinary incontinence.
OBJECTIVES Determine the cognitive effect , safety , and tolerability of oral extended-release oxybutynin in cognitively impaired older nursing home residents with urge urinary incontinence . DESIGN R and omized , double-blinded , placebo-controlled trial . SETTING Twelve skilled nursing homes . PARTICIPANTS Fifty women aged 65 and older with urge incontinence and cognitive impairment . INTERVENTION Four-week treatment with once-daily oral extended-release oxybutynin 5 mg or placebo . MEASUREMENTS Withdrawal rates and delirium or change in cognition from baseline at 1 , 3 , 7 , 14 , 21 , and 28 days after starting treatment using the Confusion Assessment Method ( CAM ) , Mini-Mental State Examination ( MMSE ) , and Severe Impairment Battery ( SIB ) . The Brief Agitation Rating Scale , adverse events , falls incidence , and serum anticholinergic activity change with treatment were also assessed . RESULTS Participants ' mean age + /-st and ard deviation was 88.6+/-6.2 , and MMSE baseline score was 14.5+/-4.3 . Ninety-six percent of subjects receiving oxybutynin ( n=26 ) and 92 % receiving placebo ( n=24 ) completed treatment ( P=.50 ) . The differences in mean change in CAM score from baseline to all time points were equivalent between the oxybutynin and placebo groups . Delirium did not occur in either group . One participant receiving oxybutynin was withdrawn because of urinary retention , which resolved without treatment . Mild adverse events occurred in 38.5 % of participants receiving oxybutynin and 37.5 % receiving placebo ( P=.94 ) . CONCLUSION Short-term treatment using oral extended-release oxybutynin 5 mg once daily was safe and well tolerated , with no delirium , in older female nursing home participants with mild to severe dementia . Future research should investigate different dosages and long-term treatment
Conclusions The use of sedatives and hypnotics and antidepressants including tricyclic antidepressants , selective serotonin reuptake inhibitors , and serotonin norepinephrine reuptake inhibitors appears to be related with an increased risk of falls .
It is not clear if the use of antihypertensive medications is associated with the risk of falls in older people
Purpose Falls are an important public health problem in older people .
Medication use is considered a risk factor for falls .
This study systematic ally review ed recent studies to determine the medications that might be associated with the risk of falling in older people .