Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .
Inorganic phosphorus reduces hypercalciuria during total parenteral nutrition by enhancing renal tubular calcium absorption.
BACKGROUND Increasing the inorganic phosphorus content of total parenteral nutrition ( TPN ) formulas has been shown to decrease TPN-induced hypercalciuria in experimental animals and humans . The mechanism of this effect , however , has been uncertain . METHODS By using a r and omized cross-over design , seven patients on cyclic TPN  were given otherwise identical formulas providing either 15 or 45 mmol/d of inorganic phosphorus .  Urinary calcium excretion , serum ultrafilterable calcium , filtered calcium load , fractional calcium excretion , urinary cyclic adenosine 5'-monophosphate ( cAMP ) , and serum levels of ionized calcium , parathyroid hormone ( PTH ) , and vitamin D metabolites were determined at the end of each study period . RESULTS Urinary calcium excretion was significantly lower when the patients received the higher inorganic phosphorus formula . Increasing the inorganic phosphorus in the TPN formula did not change ultrafilterable calcium or filtered calcium load , but significantly reduced fractional calcium excretion . No differences in serum levels of ionized calcium , PTH , 25-hydroxyvitamin D , 1,25-dihydroxyvitamin D , or urinary cAMP were observed between treatments . CONCLUSIONS These results demonstrate that increasing the inorganic phosphorus content of the TPN formula decreases urinary calcium excretion by increasing renal tubular calcium resorption . This effect is not due to alterations in the PTH-1,25-dihydroxyvitamin D axis , but likely reflects a direct action of inorganic phosphorus on the renal tubules
Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .