The current meta- analysis revealed that probiotic supplementation may result in increasing TAC and lowering MDA , which improve antioxidant status .
Previous studies have supposed that probiotic supplementation led to a positive effect on different health outcomes .
Furthermore , several studies indicated that probiotics supplementation improved antioxidant status , while some studies did not indicate these effects .
Hence , current systematic review and meta- analysis study was conducted to determine the effect of probiotic supplementation on some oxidative stress biomarkers  among adult subjects .
High dose probiotic and prebiotic cotherapy for remission induction of active Crohn's disease.
BACKGROUND Clinical trials of probiotic treatment for Crohn 's disease ( CD ) have yielded conflicting results . This study assessed the clinical usefulness of combined probiotic and prebiotic therapy in the treatment of active CD . METHOD Ten active CD out patients without history of operation for CD were enrolled . Their mean ( + /-SD ) age was 27 + /- 7 years and the main symptoms presented were diarrhea and abdominal pain . Patients ' initial therapeutic regimen of aminosalicylates and prednisolone failed to achieve remission . Patients were thus initiated on a synbiotic therapy , consisting of both probiotics ( 75 billion colony forming units [ CFU ] daily ) and prebiotics ( psyllium 9.9 g daily ) . Probiotics mainly comprised Bifidobacterium and Lactobacillus . Patients were free to adjust their intake of probiotics or prebiotics throughout the trial . Crohn 's disease activity index ( CDAI ) , International Organization for the Study of Inflammatory Bowel Disease ( IOIBD ) score and blood sample variables were evaluated and compared before and after the trial . RESULTS The duration of the trial was 13.0 + /- 4.5 months . By the end of therapy , each patient had taken a 45 + /- 24 billion CFU daily probiotic dose , with six patients taking an additional 7.9 + /- 3.6 g daily psyllium dose . Seven patients had improved clinical symptoms following combined probiotic and prebiotic therapy . Both CDAI and IOIBD scores were significantly reduced after therapy ( 255 - 136 , P = 0.009 ; 3.5 - 2.1 , P = 0.03 , respectively ) . Six patients had a complete response , one had a partial response , and three were non-responders . Two patients were able to discontinue their prednisolone therapy , while four patients decreased their intake . There were no adverse events . CONCLUSION High-dose probiotic and prebiotic cotherapy can be safely and effectively used for the treatment of active CD
The current meta- analysis revealed that probiotic supplementation may result in increasing TAC and lowering MDA , which improve antioxidant status .
Previous studies have supposed that probiotic supplementation led to a positive effect on different health outcomes .
Furthermore , several studies indicated that probiotics supplementation improved antioxidant status , while some studies did not indicate these effects .
Hence , current systematic review and meta- analysis study was conducted to determine the effect of probiotic supplementation on some oxidative stress biomarkers  among adult subjects .