In both rodent and cell culture models , CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus .
In rodent models , CBD was found to attenuate alcohol-induced hepatotoxicity , specifically , alcohol-induced steatosis .
Finally , findings from pre clinical rodent models also indicate that CBD attenuates cue-elicited and stress-elicited alcohol seeking , alcohol self-administration , withdrawal-induced convulsions , and impulsive discounting of delayed rewards .
In human studies , CBD was well tolerated and did not interact with the subjective effects of alcohol .
Collectively , given its favorable effects on alcohol-related harms and addiction phenotypes in pre clinical models , CBD appears to have promise as a c and i date AUD pharmacotherapy .
This is further bolstered by the absence of abuse liability and its general tolerability .
There is substantial interest in the therapeutic potential of cannabidiol ( CBD ) , a nonpsychoactive cannabinoid found in plants of the genus Cannabis .
The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a c and i date pharmacotherapy for alcohol use disorder ( AUD ) .
The effect of cannabidiol, alone and in combination with ethanol, on human performance
Fifteen volunteers received cannabidiol ( CBD ) ( 320 μg/kg ) or placebo ( both orally , T0 ) , and 60 min later they consumed an ethanolic beverage ( 0.54 g/kg ) or placebo . The effects were measured at T1 ( 100 min after CBD ingestion ) , T2 ( 160 min ) and T3 ( 220 min ) using cognitive , perceptual and motor function tests . Factorial analysis indicated that test procedures could be adequately expressed by three rotated factors : A reaction speed factor ( I ) , a st and ing steadiness factor ( II ) and a psychomotor coordination/cognitive factor ( III ) . Ethanol produced a significant decrement in factor III . There was no demonstrable effect of CBD , either alone or in combination with ethanol . Neither CBD nor ethanol produced any significant effect on pulse rate . Prior administration of CBD did not significantly affect the blood ethanol levels . Whilst the subjects were able to identify correctly when they were given ethanol , they did not report any subjective effects of CBD
In both rodent and cell culture models , CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus .
In rodent models , CBD was found to attenuate alcohol-induced hepatotoxicity , specifically , alcohol-induced steatosis .
Finally , findings from pre clinical rodent models also indicate that CBD attenuates cue-elicited and stress-elicited alcohol seeking , alcohol self-administration , withdrawal-induced convulsions , and impulsive discounting of delayed rewards .
In human studies , CBD was well tolerated and did not interact with the subjective effects of alcohol .
Collectively , given its favorable effects on alcohol-related harms and addiction phenotypes in pre clinical models , CBD appears to have promise as a c and i date AUD pharmacotherapy .
This is further bolstered by the absence of abuse liability and its general tolerability .
There is substantial interest in the therapeutic potential of cannabidiol ( CBD ) , a nonpsychoactive cannabinoid found in plants of the genus Cannabis .
The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a c and i date pharmacotherapy for alcohol use disorder ( AUD ) .