Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .
Phosphate supplementation in young men: lack of effect on calcium homeostasis and bone turnover
Objective : To examine the effect of phosphate supplements on calcium homeostasis and bone turnover in young men . Design : Study 1 was a r and omised , controlled , cross-over trial of 1000 mg elemental phosphate given for one week , with a st and ard diet of 800 mg/d each of calcium and phosphorus . Study 2 was an escalating dose study of 0 , 1000 , 1500 and 2000 mg/d elemental phosphate , each given for one week , with a st and ard diet of 1000 mg/d each of calcium and phosphate . Setting : Northern General Hospital , Sheffield . Subjects : Study 1 , 10 healthy men ages 19–32 y. Study 2 , 12 healthy men ages 19–38 y. Interventions : Sodium acid phosphate tablets each containing 500 mg elemental phosphorus ( 16.1 mmol/d ) , given with meals . Results : Study 1 , administration of 32.2 mmol/d phosphorus result ed in a mean increase of 13.2 mmol/d urinary phosphorus , a mean decrease of 1.1 mmol/d urinary calcium , and a mean increase of 7 ng/mL in serum intact PTH . There were no changes in serum phosphate , osteocalcin or urinary N-telopeptide excretion . Study 2 , administration of 64.4 mmol/d phosphorus result ed in a mean increase of 27.2 mmol/d urinary phosphorus , a mean decrease of 2.4 mmol/d urinary calcium , with no change in serum phosphate , PTH or urinary deoxypyridinoline . Conclusions : Phosphate supplementation of the diet does not affect bone turnover in young men . Sponsorship : Arthritis and Rheumatism Council Programme Grant
Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .