We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .
The effect of fatty or lean fish intake on inflammatory gene expression in peripheral blood mononuclear cells of patients with coronary heart disease
Background Little is known about the effect of fish consumption on gene expression of inflammation-related genes in immune cells in coronary heart disease ( CHD ) . Aim of the study We sought to evaluate the effect of a fatty fish ( FF ) or a lean fish ( LF ) diet on the modulation of inflammatory and endothelial function-related genes in peripheral blood mononuclear cells ( P BMC s ) of subjects with CHD , and its association with serum fatty acid ( FA ) profile and lipid metabolic compounds . Methods Data from 27 patients r and omized into an 8-week FF ( n = 10 ; mean ± SD : 4.3 ± 0.4 portions of fish per week ) , LF ( n = 11 ; 4.7 ± 1.1 portions of fish per week ) , or control diet ( n = 6 ; 0.6 ± 0.4 portions of fish per week ) were analyzed . The mRNA expression was measured using real-time PCR . Results The effect of the intervention on the mRNA expression of the genes studied did not differ among groups . In the FF group , however , the decrease in arachidonic acid to eicosapentaenoic acid ( AA : EPA ) ratio in cholesterol ester and phospholipid fractions strongly correlated with the change in IL1B mRNA levels ( rs = 0.60 , P = 0.06 and rs = 0.86 , P = 0.002 , respectively ) . In the LF group , the decrease in palmitic acid and total saturated FAs in cholesterol esters correlated with the change in intercellular cell adhesion molecule-1 ( ICAM1 ) expression ( rs = 0.64 , P = 0.04 for both ) . Circulating levels of soluble ICAM-1 decreased only in the LF group ( P < 0.05 ) . Conclusions The intake of FF or LF diet did not alter the expression of inflammatory and endothelial function-related genes in P BMC s of patients with CHD . However , the decrease in AA : EPA ratio in serum lipids in the FF group may induce an anti-inflammatory response at mRNA levels in P BMC s. A LF diet might benefit endothelial function , possibly mediated by the changes in serum FA composition
We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .