Conclusions Short-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders
Background Fish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases , such as cardiovascular disease , type 2 diabetes and several types of cancers .
However , the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial .
This meta- analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aim ed to evaluate whether fish oil supplementation could improve insulin sensitivity .
Effects of DHA-enriched fish oil on monocyte/macrophage activation marker sCD163, asymmetric dimethyl arginine, and insulin resistance in type 2 diabetic patients.
BACKGROUND The beneficial effects of n-3 polyunsaturated fatty acids on reducing cardiovascular risks are well documented . However , the relative effect on some markers of macrophage activation and vascular function is unclear . OBJECTIVE The primary objective of this study was to investigate the effects of docosahexaenoic acid (DHA)-enriched fish oil on the marker of monocyte/macrophage activation factor soluble CD163 , asymmetric dimethyl arginine ( ADMA ) , and insulin resistance in type 2 diabetic patients . METHODS In this double-blind r and omized controlled trial , 72 type 2 diabetic patients with an age between 30 - 70 years and body mass index ( BMI ) of 18.5 to 40 kg/m(2 ) were r and omly assigned to receive 2.4-g DHA-enriched fish oil or placebo per day for 8 weeks . Anthropometric measurements , biochemical , and body composition analyses were assessed at baseline and end of study . Analysis of covariance ( ANCOVA ) was conducted by controlling for possible confounders to assess between-group differences . RESULTS Serum levels of sCD163 , triglycerides , waist circumference ( WC ) , and weight to height ratio ( WHtR ) decreased significantly in the fish oil group when compared with the control group . Serum ADMA concentration decreased in the fish oil group with no significant between-group differences . Controlling for confounders revealed that the differences observed in sCD163 , triglycerides , WC , and WHtR remained statistically significant . CONCLUSIONS Short-time fish oil supplementation decreased serum sCD163 , triglycerides levels , WC , and WHtR  in T2DM patients . Because of the positive relationship between sCD163 levels and some T2DM and obesity-related complications , it seems that DHA can be considered as a key intervention in obesity and T2DM
Conclusions Short-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders
Background Fish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases , such as cardiovascular disease , type 2 diabetes and several types of cancers .
However , the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial .
This meta- analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aim ed to evaluate whether fish oil supplementation could improve insulin sensitivity .