Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Long-term effects of weight loss with a very low carbohydrate and low fat diet on vascular function in overweight and obese patients.
OBJECTIVE To compare the effects of an energy reduced very low carbohydrate , high saturated fat diet ( LC ) and an isocaloric high carbohydrate , low fat diet ( LF ) on endothelial function after 12 months . DESIGN AND SUBJECTS Forty-nine overweight or obese patients ( age 50.0 + /- 1.1 years , BMI 33.7 + /- 0.6 kg m(-2 ) ) were r and omized to either an energy restricted ( approximately 6 - 7 MJ ) , planned isocaloric LC or LF for 52 weeks . Body weight , endothelium-derived factors , flow-mediated dilatation ( FMD ) , adiponectin , augmentation index ( AIx ) and pulse wave velocity ( PWV ) were assessed . All data are mean + /- SEM . RESULTS Weight loss was similar in both groups ( LC -14.9 + /- 2.1 kg , LF -11.5 + /- 1.5 kg ; P = 0.20 ) . There was a significant time x diet effect for FMD ( P = 0.045 ) ; FMD decreased in LC ( 5.7 + /- 0.7 % to 3.7 + /- 0.5 % ) but remained unchanged in LF ( 5.9 + /- 0.5 % to 5.5 + /- 0.7 % ) . PWV improved in both groups ( LC -1.4 + /- 0.6 m s(-1 ) , LF -1.5 + /- 0.6 m s(-1 ) ; P = 0.001 for time ) with no diet effect ( P = 0.80 ) . AIx and VCAM-1 did not change in either group . Adiponectin , eSelectin , tPA and PAI-1 improved similarly in both groups ( P < 0.01 for time ) . CONCLUSION Both LC and LF hypoenergetic diets achieved similar reductions in body weight and were associated with improvements in PWV and a number of endothelium-derived factors . However , the LC diet impaired FMD suggesting chronic consumption of a LC diet may have detrimental effects on endothelial function
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .