In summary , the current meta- analysis demonstrated that melatonin supplementation  significantly decreased SBP and DBP in patients with metabolic disorders .
The current systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to evaluate the potential effect of melatonin supplementation on  blood pressure in patients with metabolic disorders .
Melatonin reduces night blood pressure in patients with nocturnal hypertension.
PURPOSE Nocturnal hypertension is associated with a high risk of morbidity and mortality . A blunted nocturnal surge in melatonin excretion has been described in nondipping hypertensive patients . We therefore studied the potency of melatonin to reduce nighttime blood pressure ( BP ) in treated hypertensive patients with nocturnal hypertension . PATIENTS AND METHODS Thirty-eight treated hypertensive patients ( 22 males , mean age 64+/-11 years ) with confirmed nocturnal hypertension ( mean nighttime systolic BP > 125 mm Hg ) , according to repeated 24-hour ambulatory blood pressure monitoring ( ABPM ) , were r and omized in a double-blind fashion to receive either controlled release (CR)-melatonin 2 mg or placebo 2 hours before bedtime for 4 weeks . A 24-hour ABPM was then performed . RESULTS Melatonin treatment reduced nocturnal systolic BP significantly from 136+/-9 to 130+/-10 mm Hg ( P=.011 ) , and diastolic BP from 72+/-11 to 69+/-9 mm Hg ( P=.002 ) , whereas placebo had no effect on nocturnal BP . The reduction in nocturnal systolic BP was significantly greater with melatonin than with placebo ( P=.01 ) , and was most prominent between 2:00 AM and 5:00 AM ( P=.002 ) . CONCLUSIONS Evening CR-melatonin 2 mg treatment for 4 weeks significantly reduced nocturnal systolic BP in patients with nocturnal hypertension . Thus , an addition of melatonin 2 mg at night to stable antihypertensive treatment may improve nocturnal BP control in treated patients with nocturnal hypertension
In summary , the current meta- analysis demonstrated that melatonin supplementation  significantly decreased SBP and DBP in patients with metabolic disorders .
The current systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to evaluate the potential effect of melatonin supplementation on  blood pressure in patients with metabolic disorders .