Bariatric surgery leads to marked and long-lasting weight reduction .
A large proportion of patients undergoing bariatric surgery have DM2 .
Glycemic control improves in the months after laparoscopic adjustable gastric b and ing , but it improves more rapidly and completely after laparoscopic Roux-en-Y gastric bypass surgery .
Thus , both types of surgery are capable of improving or even curing DM2 , but the mechanisms may differ
OBJECTIVE To systematic ally review the literature pertaining to the reversal of  type 2 diabetes mellitus ( DM2 ) after Roux-en-Y gastric bypass and adjustable gastric b and ing .
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients
Summary Glucagon-like peptide 1 ( GLP-1 ) ( 7 - 36 amide ) is a physiological incretin hormone that is released after nutrient intake from the lower gut and stimulates insulin secretion at elevated plasma glucose concentrations . Previous work has shown that even in Type 2 ( non-insulin-dependent ) diabetic patients GLP-1 ( 7 - 36 amide ) retains much of its insulinotropic action . However , it is not known whether the magnitude of this response is sufficient to normalize plasma glucose in Type 2 diabetic patients with poor metabolic control . Therefore , in 10 Type 2 diabetic patients with unsatisfactory metabolic control ( HbAlc 11.6±1.7 % ) on diet and sulphonylurea therapy ( in some patients supplemented by metformin or acarbose ) , 1.2 pmol ×kg−1 × min−1 GLP-1 ( 7 - 36 amide ) or placebo was infused intravenously in the fasting state ( plasma glucose 13.1±0.6 mmol/l ) . In all patients , insulin ( by 17.4±4.7 nmol ×1−1 × min ; p=0.0157 ) and C-peptide ( by 228.0±39.1 nmol × 1−1 × min ; p=0.0019 ) increased significantly over basal levels , glucagon was reduced ( by -1418±308 pmol ×1−1 × min ) and plasma glucose reached normal fasting concentrations ( 4.9±0.3 mmol/l ) within 4 h of GLP-1 ( 7 - 36 amide ) administration , but not with placebo . When normal fasting plasma glucose concentrations were reached insulin returned towards basal levels and plasma glucose concentrations remained stable despite the ongoing infusion of GLP-1 ( 7 - 36 amide ) . Therefore , exogenous GLP-1 ( 7 - 36 amide ) is an effective means of normalizing fasting plasma glucose concentrations in poorly-controlled Type 2 diabetic patients . The glucose-dependence of insulinotropic actions of GLP-1 ( 7 - 36 amide ) appears to be retained in such patients
Bariatric surgery leads to marked and long-lasting weight reduction .
A large proportion of patients undergoing bariatric surgery have DM2 .
Glycemic control improves in the months after laparoscopic adjustable gastric b and ing , but it improves more rapidly and completely after laparoscopic Roux-en-Y gastric bypass surgery .
Thus , both types of surgery are capable of improving or even curing DM2 , but the mechanisms may differ
OBJECTIVE To systematic ally review the literature pertaining to the reversal of  type 2 diabetes mellitus ( DM2 ) after Roux-en-Y gastric bypass and adjustable gastric b and ing .