Conclusion The SLOF was the most often used functional measure and had the strongest observed correlation with the UPSA .
Although knowledge gaps remain , evidence from this review indicates that there is a quantitative relationship between functional capacity and real-world outcomes in individuals with schizophrenia
Objective To perform a systematic review of the published literature to evaluate how functional capacity , as measured by the University of California at San Diego ( UCSD ) Performance-based Skills Assessment ( UPSA ) , relates to other functional measures and real-world outcomes among individuals with schizophrenia .
Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naı̈ve patients with schizophrenia
The early course of neuropsychological dysfunction in schizophrenia and the impact of treatment on these deficits need to be better specified . A sample of 45 patients with schizophrenia underwent five neuropsychological evaluations from prior to treatment with antipsychotic treatment through a 2-year follow-up period . A comparison sample of 33 matched healthy individuals underwent neuropsychological evaluations at similar time points . At baseline , a generalized deficit across cognitive domains was evident for the schizophrenia sample . After 6 weeks of treatment , patients showed modest improvements in visual memory and visual perception , but a decline in verbal memory . Verbal memory performance returned to baseline levels by the 6-month follow-up while deficits in other neuropsychological domains persisted throughout the 2-year period . Relatively static and generalized neuropsychological dysfunction , evident from illness onset , is consistent with neurodevelopmental rather than neurodegenerative models of schizophrenia
Conclusion The SLOF was the most often used functional measure and had the strongest observed correlation with the UPSA .
Although knowledge gaps remain , evidence from this review indicates that there is a quantitative relationship between functional capacity and real-world outcomes in individuals with schizophrenia
Objective To perform a systematic review of the published literature to evaluate how functional capacity , as measured by the University of California at San Diego ( UCSD ) Performance-based Skills Assessment ( UPSA ) , relates to other functional measures and real-world outcomes among individuals with schizophrenia .