The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
A comparison of stabilized stannous fluoride dentifrice and triclosan/copolymer dentifrice for efficacy in the reduction of gingivitis and gingival bleeding: six-month clinical results.
This parallel-group , double-blind , placebo-controlled clinical trial directly compared the efficacy of two  antimicrobial dentifrice formulations for the control of plaque , gingivitis and gingival bleeding during six months of use following a pre-test r and omization period . Test antimicrobial dentifrices for the study included : a stabilized stannous fluoride formulation ( Crest Plus Gum Care-currently marketed in U.S. ) comprised of 0.454 % SnF2 in a stabilized silica abrasive base ; and a formulation containing triclosan ( Colgate Total , currently marketed outside the U.S. in numerous countries ) comprised of 0.30 % triclosan . 2.0 % Gantrez co-polymer and 0.243 % NaF in a silica abrasive base . The control dentifrice was a conventional fluoride dentifrice comprised of 0.243 % NaF in a silica abrasive base . Clinical evaluations included Turesky et al. plaque , Löe-Silness gingivitis and gingival bleeding , and Meckel stain . The stabilized stannous fluoride dentifrice exhibited significant efficacy in the reduction of both gingivitis ( 20.5 % ) and gingival bleeding ( 33.4 % ) after six months relative to the placebo control ( p < 0.05 ) . In direct comparison , the stabilized stannous fluoride dentifrice reduced gingivitis and gingival bleeding significantly relative to the triclosan/copolymer dentifrice ( p < 0.05 ) . These results establish : 1 ) the superior clinical efficacy of a stabilized stannous fluoride dentifrice relative to a triclosan/copolymer dentifrice in the chemotherapeutic control of gingivitis and gingival bleeding ; 2 ) the important contribution of clinical test design /sensitivity in assessing the therapeutic efficacy of antimicrobial agents ; and 3 ) the value of head-to-head comparative studies in establishing the therapeutic relevance of clinical effects of formulations for the reduction of gingivitis
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .