We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .
Role of renin classification for diuretic treatment of black hypertensive patients.
Previous studies in white and mixed-race hypertensive patient population s have generally found patients with low renin activity more responsive to diuretic therapy than patients with normal renin activity . Twenty-nine black patients ( 26 women and three men ) with placebo diastolic blood pressure of 90 to 115 mm Hg were treated with spironolactone ( 100 to 400 mg/day ) and hydrochlorothiazide ( 100/mg/day ) . Renin status was categorized by ( 1 ) the intravenous furosemide test , ( 2 ) ambulation during  placebo , and ( 3 ) ambulation during spironolactone and hydrochlorothiazide treatment . Only seven patients were categorized identically with all methods . No method identified a low renin subgroup that was more responsive to either spironolactone or hydrochlorothiazide .  Diastolic blood pressure fall with hydrochlorothiazide ( 18 mm Hg ) and 400 mg/day of spironolactone ( 15 mm Hg ) was similar . Thus , since black women with both low and normal renin activity are quite responsive to diuretics , renin classification to guide initial antihypertensive selection is not warranted
We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .