In conclusion , the deficiency of vitamin D is associated with an increased level of BMI in the studies of both diabetic and non-diabetic subjects .
The deficiency of vitamin D is prevalent all over the world .
Studies have shown that vitamin D may play an important role in the development of obesity .
The current study was conducted to quantitatively evaluate the association between serum 25-(OH ) vitamin D levels  and the risk of obesity in both diabetic and non-diabetic subjects .
Vitamin D and C-Reactive Protein: A Mendelian Randomization Study
Vitamin D deficiency is widely prevalent and has been associated with many diseases . It has been suggested that vitamin D has effects on the immune system and inhibits inflammation . The aim of our study was to investigate whether vitamin D has an inhibitory effect on systemic inflammation by assessing the association between serum levels of vitamin D and C-reactive protein . We studied the association between serum 25-hydroxyvitamin D and C-reactive protein through linear regression in 9,649 participants of the Rotterdam Study , an observational , prospect i ve population -based cohort study . We used genetic variants related to vitamin D and CRP to compute a genetic risk score and perform bi-directional Mendelian r and omization analysis . In linear regression adjusted for age , sex , cohort and other confounders , natural log-transformed CRP decreased with 0.06 ( 95 % CI : -0.08 , -0.03 ) unit per st and ard deviation increase in 25-hydroxyvitamin D. Bi-directional Mendelian r and omization analyses showed no association between the vitamin D genetic risk score and lnCRP ( Beta per SD = -0.018 ; p = 0.082 ) or the CRP genetic risk score and 25-hydroxyvitamin D ( Beta per SD = 0.001 ; p = 0.998 ) . In conclusion , higher levels of Vitamin D are associated with lower levels of C-reactive protein . In this study we did not find evidence for this to be the result of a causal relationship
In conclusion , the deficiency of vitamin D is associated with an increased level of BMI in the studies of both diabetic and non-diabetic subjects .
The deficiency of vitamin D is prevalent all over the world .
Studies have shown that vitamin D may play an important role in the development of obesity .
The current study was conducted to quantitatively evaluate the association between serum 25-(OH ) vitamin D levels  and the risk of obesity in both diabetic and non-diabetic subjects .