On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Pindolol and methylphenidate in children with attention-deficit hyperactivity disorder. Clinical efficacy and side-effects.
The purpose of this study was to examine the efficacy and side-effects of pindolol , a beta-blocker , in children with attention-deficit hyperactivity disorder ( ADHD ) . Fifty-two ADHD children , 7 - 13 years old , participated in a prospect i ve double-blind placebo-controlled comparison of pindolol and methylpheni date ( MPH ) . Active treatment was pindolol and MPH : pindolol 20 mg b.i.d . or MPH 10 mg b.i.d . for 4 weeks . The outcome was assessed on the basis of the Abbreviated Conners Rating Scales ( ACRS ) completed by parents , teachers , and by a psychologist during psychological testing . Pindolol treatment was associated with a higher incidence of paraesthesias and with more intense nightmares and hallucinations than MPH or placebo treatment . These side-effects led to an interim change in design by ending pindolol treatment after 32 participants . Pindolol proved to be just as effective as MPH in decreasing hyperactivity and conduct problems at home , and hyperactivity problems at school .  Pindolol , however , had less therapeutic effects than MPH during psychological testing , and failed to affect conduct problems in school . In sum , pindolol was modestly effective in the treatment of ADHD . Safety concerns on troubling side-effects clearly limit the use of it
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .