Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .
Routine use of antibiotic prophylaxis in low-risk laparoscopic cholecystectomy is unnecessary: a randomized clinical trial.
BACKGROUND Laparoscopic cholecystectomy uses smaller incision and trocars that lessen the contamination and exposure of wound , result ing in less infection . However , the antibiotic prophylaxis is still widely practice d , like in our institute , a continuation of the era of open surgery . Recent studies reveal no advantage of routine use of antibiotic , and there is growing consensus against it . Besides cost , antibiotic increases emergence of multidrug resistance . Because of the controversies , we conducted this clinical trial . METHODS This r and omized clinical trial , conducted from October 1 , 2009 to September 31 , 2010 at Patan Hospital , included 154 patients in prophylactic antibiotic group ( GrAP ) with cefazolin 1 g IV  as per existing practice and 156 in  no antibiotic group ( GrAPn ) . Symptomatic laparoscopic cholecystectomy patients of American Society of Anesthesiologist ( ASA ) 1 and 2 ( without diabetes ) were included . Patients with complicated gall stones ( cholangitis , choledocholithiasis , and pancreatitis ) and who required conversion were excluded . Wound was observed during follow-up within 1 week . Data on patient characteristics , use of antibiotic , bile spillage , and postoperative wound infection were entered in pre design ed proforma . Microsoft Excel was used to analyze the data . RESULTS In total , 310 patients were eligible for analysis , 154 in GrAP and 156 in GrAPn . Both groups were comparable in patient demographic and clinical characteristics such as average age ( 40.3 vs. 41.6 years ) and sex ( female 77.6 % vs. 78.6 % ) .  Overall wound infection occurred in 4.8 % ( 15/310 ) . There was no significant difference in wound infections among the two groups ( p = 0.442 ) : GrAP 3.9 % and GrAPn 5.8 % . There was no mortality in this series . CONCLUSION Routine preoperative antibiotic prophylaxis is not necessary in low-risk symptomatic gallstone patients undergoing laparoscopic cholecystectomy
Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .