The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
Efficacy of a mouthrinse containing 0.05% cetylpyridinium chloride for the control of plaque and gingivitis: a 6-month clinical study in adults.
The objective of this 6-month , double-blind , clinical study , conducted following the American Dental Association ( ADA ) guidelines , was to provide an assessment of the effectiveness of a newly developed mouthrinse containing 0.05 % cetylpyridinium chloride ( CPC ) for the control of supragingival dental plaque and gingivitis . Adult men and women from the Manchester , Engl and , area were entered in the study , and stratified into two treatment groups ( CPC mouthrinse and control mouthrinse ) , which were balanced for baseline Quigley-Hein Plaque Index scores and baseline Löe-Silness Gingival Index scores . Participants were given an oral prophylaxis and instructed to brush their teeth twice daily ( morning and evening ) for 1 minute with a soft-bristled toothbrush and fluoride dentifrice provided , immediately followed by rinsing for 30 seconds with 15 cc of their assigned mouthrinse . Examinations for supragingival plaque and gingivitis were conducted after 3 months ' and again after 6 months ' participation in the study . One hundred eleven participants complied with the protocol and completed the entire 6-month clinical study . At both the 3- and 6-month study examinations , the CPC mouthrinse group exhibited statistically significantly less supragingival plaque and gingivitis than did the control mouthrinse group . At the 6-month examination , the magnitude of these differences met or exceeded 24 % for all 4 parameters measured ( 28.2 % for Quigley-Hein Plaque Index , 63.4 % for Plaque Severity Index , 24.0 % for Löe-Silness Gingival Index , and 66.9 % for Gingivitis Severity Index ) . The magnitude of the reductions in supragingival plaque and gingivitis were adequately large to support a cl aim of efficacy , in accordance with the criteria provided by the published guidelines of the ADA for the demonstration of the efficacy of a chemotherapeutic agent for the control of supragingival plaque and gingivitis . Thus , the results of this 6-month clinical study support the conclusion that a newly developed mouthrinse containing 0.05 % cetylpyridinium chloride provides a statistically significant , clinical ly relevant level of efficacy for the control of supragingival plaque , and for the control of gingivitis , in accordance with the criteria provided by current ADA guidelines
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .