Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .
Restoration of Penile Function and Patient Satisfaction with Intralesional Collagenase Clostridium Histolyticum Injection for Peyronie's Disease.
PURPOSE Collagenase clostridium histolyticum is approved for the treatment of Peyronie 's disease . To date , no post-release study to our knowledge has evaluated patient perceived outcomes and satisfaction . Therefore , we evaluated patient perceived experience with collagenase clostridium histolyticum injection for Peyronie 's disease in a clinical practice . MATERIAL S AND METHODS From March 2014 to July 2015 , 69 patients underwent 1 to 4 series of collagenase clostridium histolyticum injections for Peyronie 's disease at our institution . Objective changes in penile curvature as well as patient reported functional outcomes and patient perceived curvature improvements were evaluated . RESULTS By the time of analysis 31 patients ( 45 % ) had completed 4 trials , 47 ( 68 % ) completed 3 trials and 59 ( 86 % ) completed 2 trials . Patient reported improvements ( percentage ) in curvature increased with each series ( trial 1 - 14 % , trial 2 - 28 % , trial 3 - 30 % and trial 4 - 37 % , p < 0.05 ) . Among those completing therapy 57 % reported that collagenase clostridium histolyticum injections negated a need for surgery and 52 % reported restoration of penetration . Overall 81 % of men perceived collagenase clostridium histolyticum treatment as meaningful and 88 % reported subjective improvements after 4 series of injections . Objective measures demonstrated a mean 23-degree curvature improvement ( 38 % , p < 0.0001 ) . Seven patients ( 10 % ) experienced penile hematomas and no patients experienced tunical rupture . CONCLUSIONS Collagenase clostridium histolyticum reduced the need for surgery and restored penetration in the majority of patients completing 4 series of injections . It also significantly reduced the degree of objective ly measured penile curvature . Subjective improvements in curvature increased with each series of collagenase clostridium histolyticum injections as well and the majority of patients considered the therapy worthwhile
Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .