There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
The Effect of Fish Oil Supplementation on Heart rate in Healthy Danish Infants
Polyunsaturated n-3 fatty acids ( n-3PUFA ) may improve brain development and prevent cardiovascular disease . Heart rhythm is autonomically controlled and among the affected cardiovascular risk markers in adults . The aim of the study was to examine whether fish oil supplementation in late infancy could modify heart rate ( HR ) and heart rate variability ( HRV ) . In a 2 × 2-intervention , 83 healthy Danish infants were r and omized to ± fish oil ( 3.4 ± 1.1 mL/d ) and cow 's milk or infant formula from 9 to 12 mo of age . In 57 infants , 0.5-h ECG recordings were successfully obtained before and after the intervention and erythrocyte fatty acid composition was determined in 30 of these . Fish oil supplementation raised erythrocyte n-3PUFA content ( p < 0.001 ) . No significant group differences were seen in HR or HRV . However , a fish-oil × gender interaction was observed on mean RR interval ( p = 0.001 ) with a 6 % longer mean RR interval in fish-oil-supplemented boys ( p = 0.007 ) . Irrespective of gender , there was a positive association between the 9- and 12-mo changes in RR interval and erythrocyte n-3PUFA ( p < 0.001 ) . In infants with confirmed changes in erythrocyte n-3PUFA , mean RR interval was found to be longer ( p = 0.011 ) in the fish-oil-supplemented groups . The study suggests that fish oil may affect heart rhythm in infants similar to that observed in adults . This may imply low n-3PUFA-status in late infancy and n-3PUFA influence on CNS function
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .