Results showed no significant effects on core symptomatology .
In conclusion , up to date , evidence regarding the potential utility of IN-OT in treating anxiety and depression is still inconclusive .
Several studies have demonstrated the neuromodulating function of oxytocin ( OT ) in response to anxiogenic stimuli as well as its potential role in the pathogenesis of depression .
Consequently , intranasal OT ( IN-OT ) has been proposed as a potential treatment of  anxiety and depressive disorders .
The present systematic review aim ed to summarize the r and omized controlled trials ( RCTs ) evaluating the effect of IN-OT on anxiety and depressive symptoms .
Fear of Spiders Questionnaire.
The Fear of Spiders Question naire ( FSQ ) , an 18-item self-report question naire assessing spider phobia , was developed in an attempt to complement the information provided by the Spider Phobia Question naire ( SPQ ) . Data obtained from 338 undergraduates revealed that the FSQ was able to discriminate phobics from nonphobics , and indicated decrements in phobic responding from pretest to posttest following cognitive therapy . Test-retest data , obtained from non-treatment control groups , indicated that scores on the FSQ are stable over a one month period . The FSQ also demonstrated adequate convergent validity due to its significant correlations with the SPQ and a behavioral avoidance test . Finally , a factor analysis revealed two factors accounting for 55 % of the variance . It is argued that , compared to the SPQ , items on the FSQ are more explicit regarding the time period to be assessed , and may be more sensitive to differences between phobics and nonphobics and decrements in phobic responding following treatment
Results showed no significant effects on core symptomatology .
In conclusion , up to date , evidence regarding the potential utility of IN-OT in treating anxiety and depression is still inconclusive .
Several studies have demonstrated the neuromodulating function of oxytocin ( OT ) in response to anxiogenic stimuli as well as its potential role in the pathogenesis of depression .
Consequently , intranasal OT ( IN-OT ) has been proposed as a potential treatment of  anxiety and depressive disorders .
The present systematic review aim ed to summarize the r and omized controlled trials ( RCTs ) evaluating the effect of IN-OT on anxiety and depressive symptoms .