Using the Cochrane methodology , and as measures of effect size mean difference and Hedge 's g , SRIs proved to be superior to drug placebo , with a modest effect size .
From direct comparisons of CBT and SRI treatments , we conclude that CBT has the superior efficacy .
COMBO versus CBT shows that SRI treatment adds little to concomitant CBT , while COMBO shows favourable outcome versus SRI alone .
In pre-trial partial treatment responders , those who failed a SRI had better outcome from adding CBT as compared to continuing a SRI .
Those who failed CBT treatment did as well with continued CBT as with switching to a SRI .
Serotonin reuptake inhibiting drugs ( SRI ) have been used in the treatment of paediatric obsessive-compulsive disorder over the past 30 years .
Clomipramine hydrochloride in childhood and adolescent obsessive-compulsive disorder--a multicenter trial.
Children and adolescents with obsessive compulsive disorder were studied in an 8-week , multicenter , double-blind , parallel groups trial of clomipramine hydrochloride ( CMI ) versus placebo . Efficacy assessment s included the child version of the Yale-Brown Obsessive Compulsive Scale and the National Institute of Mental Health Global rating scale . At the end of 8 weeks , CMI-treated patients showed a mean reduction in Yale-Brown Obsessive Compulsive Scale score of 37 % compared to 8 % in the placebo group . Side effects were typical of tricyclic antidepressants . In a 1-year open label treatment , CMI continued to be effective and well tolerated
Using the Cochrane methodology , and as measures of effect size mean difference and Hedge 's g , SRIs proved to be superior to drug placebo , with a modest effect size .
From direct comparisons of CBT and SRI treatments , we conclude that CBT has the superior efficacy .
COMBO versus CBT shows that SRI treatment adds little to concomitant CBT , while COMBO shows favourable outcome versus SRI alone .
In pre-trial partial treatment responders , those who failed a SRI had better outcome from adding CBT as compared to continuing a SRI .
Those who failed CBT treatment did as well with continued CBT as with switching to a SRI .
Serotonin reuptake inhibiting drugs ( SRI ) have been used in the treatment of paediatric obsessive-compulsive disorder over the past 30 years .