There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acid
Long-chain polyunsaturated fatty acids have been associated with aspects of immune regulation including cytokine production . The purpose of this study was to investigate the effect of maternal dietary supplementation with tuna oil , rich in docosahexaenoic acid ( DHA ) , on the concentration of transforming growth factor beta 1 ( TGFβ1 ) and TGFβ2 in breast milk . In this r and omized , dietary intervention trial , mothers of term infants consumed a daily supplement of 2000 mg oil containing either placebo ( n=40 ) , 300 mg DHA ( n=40 ) , or 600 mg DHA ( n=40 ) . The DHA increase in milk and plasma was proportional to dietary DHA . There was no relationship between milk DHA status and TGFβ1 and TGFβ2 levels
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .