CONCLUSIONS Supplementation with vitamin D showed no effect on adiposity measures in adults
CONTEXT The independent or interactive effects of vitamin D and calcium on adiposity remain inconclusive .
OBJECTIVE The objective of this systematic review and meta- analysis was to assess whether vitamin D and calcium supplements cause changes in adiposity .
Dexfenfluramine as adjuvant to a low-calorie formula diet in the treatment of obesity: a randomized clinical trial.
Dexfenfluramine ( dF ) was compared to placebo as adjuvant to a very energy-restricted diet ( 1.6 - 4.2 MJ/24 h ) . The diet was continued as long as possible or until a satisfactory weight loss had been achieved , and dietary efforts were continued throughout the study . Of the 37 females and five males included , 71 per cent could be followed up for 12 months . Initial BMI ranged from 28 to 54 kg/m2 . The lowest body weight was reached 1 month earlier in the dF group ( P = 0.037 ) . Throughout the study , the reduction of excess weight ( REW ) was greater in dF patients ( P less than 0.05 only at 4 and 6 months ) . At 6 months , excess weight had declined by 15 per cent more in the dF group than in the placebo group ( 95 per cent confidence limits of the median being 1 - 31 per cent ) . Between 6 and 12 months , both groups regained weight significantly , the rates of regain differing only insignificantly . At 12 months , excess weight showed a net decrease of only 8 per cent more in the dF group than in the placebo group ( 95 per cent confidence limits being -7 to + 24 per cent ) . Therefore , REW showed no significant group difference after 12 months . Type of obesity ( and roid or gynoid ) as determined by waist to hip ratio had no significant impact on either weight loss , REW , reductions of waist and hip circumferences , or on waist to hip ratio changes . S-alkaline phosphatases and s-uric acid declined significantly in the dF group only . Side-effects were all mild and their prevalence showed no group difference . ( ABSTRACT TRUNCATED AT 250 WORDS
CONCLUSIONS Supplementation with vitamin D showed no effect on adiposity measures in adults
CONTEXT The independent or interactive effects of vitamin D and calcium on adiposity remain inconclusive .
OBJECTIVE The objective of this systematic review and meta- analysis was to assess whether vitamin D and calcium supplements cause changes in adiposity .