There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Visual Acuity and Fatty Acid Status of Term Infants Fed Human Milk and Formulas with and without Docosahexaenoate and Arachidonate from Egg Yolk Lecithin1
Preterm infants fed formulas with docosahexaenoic acid ( DHA , 22:6n-3 ) during the interval equivalent to the last intrauterine trimester and beyond have higher circulating DHA and transiently higher visual acuity compared with infants fed formulas containing linolenic acid . In term infants several nonr and omized studies of infants receiving DHA from human milk suggest a relationship between DHA status and acuity , but the evidence for a cause- and -effect relationship is mixed . In the present study , term infants were r and omly assigned to a st and ard term formula ( n = 20 ) or the same formula with egg yolk lecithin to provide DHA ( 0.1 % ) and arachidonic acid(AA , 20:4n-6 , 0.43 % ) ( n = 19 ) at levels reported in milk of American women . A third group of infants was breast fed for ≥3 mo(n = 19 ) . Grating visual acuity ( Teller Acuity Card procedure ) and plasma and red blood cell ( RBC ) phosphatidylcholine ( PC ) and phosphatidylethanolamine ( PE ) DHA and AA were determined at corrected ages of 2 , 4 , 6 , 9 ( acuity only ) , and 12 mo past term = 40 wk postmenstrual age ( PMA ) . At 2 mo breast-fed infants and infants fed the supplemented formula had higher grating acuity than term infants fed st and ard formula . As in preterm infants , the increase was transient . Plasma PC DHA and AA and RBC PE AA increased by 2 mo in supplemented infants , but RBC PE DHA in supplemented infants was not higher than in controls until 4 mo and beyond . Despite normal intrauterine accumulation of DHA and AA , infants fed formula with 2 % linolenic acid and 0.1 % DHA had better 2-mo visual acuity than infants fed formula with 2 % linolenic acid
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .