Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .
Variation in Catechol-O-Methyltransferase Is Associated with Duloxetine Response in a Clinical Trial for Major Depressive Disorder
BACKGROUND The study objective was to evaluate variations in genes implicated in antidepressant mechanism of action for association with response to duloxetine treatment in major depressive disorder ( MDD ) . METHODS We assessed response over 6 weeks in 250 duloxetine-treated Caucasian patients in a r and omized , double-blind study of patients with MDD . Single nucleotide polymorphisms ( SNPs ) were genotyped in 19 c and i date genes selected based on evidence for involvement in antidepressant mechanism of action . Primary analysis examined baseline to end point reduction in the 17-item Hamilton Depression Rating Scale ( HAMD17 ) total score , using a set-based test for association for each gene . Follow-up analyses examined individual SNPs within any significant gene for association with reduction in HAMD17 and 30-item Inventory of Depressive Symptomatology-Clinician Rated ( IDS-C-30 ) . RESULTS After correction for multiple comparisons , only COMT was associated with change in HAMD17 ( experiment wide p = .018 ) . Peak association was detected with rs165599 ( p = .006 ) , which accounted for approximately 3 % of variance in HAMD17 change and > 4 % of variance in IDS-C-30 change ( p = .001 ) . The least-squared mean change ( SE ) in HAMD17 score by rs165599 genotype was -10.8 ( 1.2 ) , -8.7 ( .6 ) , and -6.5 ( .7 ) for patients with GG , GA , and AA genotypes , respectively . For SNPs in serotonin 2A receptor ( HTR2A ) previously associated with citalopram response , including rs7997012 , no significant evidence of association with duloxetine response was identified . CONCLUSIONS Single nucleotide polymorphisms in COMT were associated with symptom change in duloxetine-treated patients with MDD . If replicated , the magnitude of the COMT genotype effect is of clinical relevance
Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .