These studies demonstrated improvement in biochemical profiles , with a decline in or normalization of liver enzymes .
However , some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis .
There has been a growing interest in the role of vitamin E supplementation in the treatment and /or prevention of nonalcoholic fatty liver ( NAFLD ) .
Furthermore , histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only .
Vitamin E supplementation, superoxide dismutase status, and outcome of scaling and root planing in patients with chronic periodontitis: a randomized clinical trial.
BACKGROUND This study investigates the levels of superoxide dismutase ( SOD ) activity in serum and saliva of patients with chronic periodontitis ( CP ) . In addition , the outcome of scaling and root planing ( SRP ) with and without vitamin E supplementation is evaluated in terms of changes in periodontal parameters and SOD activity in patients with CP . METHODS Serum and salivary SOD activity in 38 patients with CP were compared with those of 22 systemically and periodontally healthy individuals ( control group ) . At periodontal examination , serum and saliva sample s were obtained . Patients with CP were r and omly divided into treatment groups 1 ( TG-1 ) and 2 ( TG-2 ) . SRP was performed for both groups , and TG-2 also received 200 mg ( 300 IU ) vitamin E every other day . Periodontal parameters and SOD activity were evaluated after 3 months . SOD activity was determined using an SOD assay and enzyme-linked immunosorbent assay reader at 450 nm . RESULTS SOD activity in both serum ( P < 0.05 ) and saliva ( P < 0.001 ) was lower in patients with CP compared with controls . After 3 months of follow-up , SOD activity improved in both treatment groups ; however , the improvement in TG-2 was higher than in TG-1 , along with more improvement in periodontal parameters . Serum SOD levels in TG-2 increased even above the level of the control group . CONCLUSIONS Systemic and local SOD levels are lowered in CP . Adjunctive vitamin E supplementation improves periodontal healing as well as antioxidant defense
These studies demonstrated improvement in biochemical profiles , with a decline in or normalization of liver enzymes .
However , some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis .
There has been a growing interest in the role of vitamin E supplementation in the treatment and /or prevention of nonalcoholic fatty liver ( NAFLD ) .
Furthermore , histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only .