Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .
The effects of onion extract on hypertrophic and keloid scars.
OBJECTIVE To evaluate the therapeutic activity of topical onion extract in gel form on  hypertrophic and keloid scars  , focusing on problems such as elevation , redness , hardness , itching and pain . METHOD This comparative prospect i ve study assigned 60 patients to three groups . Group I was treated with onion extract alone , group 2 with silicon gel sheet alone and 3 group with a combination of onion extract and silicon gel sheet . RESULTS In the group comparisons , a significant difference was observed at the end of six months in the colour parameter between group I and group 2 and in the height parameter between group I and group 3 ( ANOVA post-hoc Tukey 's test , p<0.01 and p<0.05 respectively ) . The onion extract was more effective in relation to scar colour , while the silicon gel sheet was superior in decreasing the height of scar ( paired sample t-test , p<0.001 ) . In addition , the most effective therapeutic results were obtained when the silicon gel sheet treatment was combined with onion extract in group 3 . CONCLUSION Onion extract improved hypertrophic and keloids scars via multiple mechanisms . However , it was statistically ineffective in improving scar height and itching . For this reason , onion extract therapy should be used in combination with an occlusive silicon dressing to achieve a satisfying decrease in scar height
Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .