Conclusions There is considerable variability in the type of measures utilized to measure physical impairments and limitations in survivors of critical illness .
Purpose To identify measures used to evaluate the broad constructs of functional impairment and limitations in the critically ill across the continuum of recovery , and to evaluate , synthesis e and compare the clinimetric properties of the measures identified .
Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality*
Objectives : To assess whether the presence and severity of intensive care unit-acquired paresis are associated with intensive care unit and in-hospital mortality . Design : Prospect i ve , observational study . Setting : Two medical , one surgical , and one medico-surgical intensive care units in two university hospitals and one university-affiliated hospital . Patients : A total of 115 consecutive patients were enrolled after > 7 days of mechanical ventilation .  Interventions : None . Measurements and Main Results : The Medical Research Council score ( from 0–60 ) was used to evaluate upper and lower limb strength at time of awakening , identified as the ability to follow five comm and s. Intensive care unit-acquired paresis was defined as a Medical Research Council score < 48 . Patients were followed-up until hospital discharge . The primary end point was hospital mortality . At awakening , median Medical Research Council score was 41 ( interquartile range , 21–52 ) , and 75 ( 65 % ) patients had intensive care unit-acquired paresis . Hospital non-survivors had a significantly lower Medical Research Council score at awakening ( 21 [ 11–43 ] ) vs. 41 [ 28–53 ] ; p = .008 ) and a significantly higher rate of intensive care unit-acquired paresis ( 85.1 % vs. 58.4 % ; p = .02 ) compared to survivors . After multivariate risk adjustment , intensive care unit-acquired paresis was independently associated with higher hospital and intensive care unit mortality ( odds ratio for hospital mortality , 2.02 ; 95 % confidence interval , 1.03–8.03 ; p = .048 ) . Each Medical Research Council point decrease was associated with a significantly higher hospital mortality ( odds ratio , 1.03 ; 95 % confidence interval , 1.01–1.05 ; p = .033 ) . Conclusions : Both the presence and severity of intensive care unit-acquired paresis at the time of awakening are associated with increased intensive care unit and hospital mortality ; the mechanisms underlying this association need further study
Conclusions There is considerable variability in the type of measures utilized to measure physical impairments and limitations in survivors of critical illness .
Purpose To identify measures used to evaluate the broad constructs of functional impairment and limitations in the critically ill across the continuum of recovery , and to evaluate , synthesis e and compare the clinimetric properties of the measures identified .