In most respects , all membranes and enamel matrix derivative ( EMD ) delivered better outcomes , in the range of 1 to 2 mm , than open flap debridement .
The use of any barrier type or EMD configuration was found to yield more Clinical Attachment Level ( CAL ) gain than any open flap configuration .
GTR was confirmed to be superior to open flap debridement
In a 1998 review article , Laurell and colleagues performed a meta- analysis of relevant guided tissue regeneration ( GTR ) articles over the previous 20 years ( 1 ) .
The purpose of the present research was to exp and on that work , particularly search ing for trends discriminating between bioabsorbable and non-bioabsorbable barriers , as well as the use of enamel matrix derivative , with respect to interproximal bony defects .
Effect of repeated local minocycline administration on periodontal healing following guided tissue regeneration.
BACKGROUND  Infection after a periodontal surgical site has been prepared for guided tissue regeneration ( GTR ) is one of the common complications that can compromise healing . The purpose of this study was to assess the effect of repeated local antimicrobial therapy following GTR for improving clinical attachment gains , and to histologically evaluate the various cell population s and bacterial contamination of the retrieved exp and ed polytetrafluoroethylene membrane ( ePTFE ) . METHODS Forty periodontal intrabony defects in 40 patients were treated by a flap procedure that included the use of  ePTFE membranes  to allow GTR . Patients were r and omly assigned to 2 treatment groups : 20 patients were treated with the ePTFE alone ( control group ) , and the other 20 were treated with the ePTFE combined with the administration of a weekly repeated local application of minocycline ointment for 8 weeks after membrane placement ( test group ) . The membranes were retrieved 6 weeks after the initial surgery and sectioned serially in a coronal-apical plane . The sections were then divided into 9 fields and examined by light microscopy for the presence of inflammatory cells and oral bacteria . Clinical measurements were taken at the time of baseline examination and at a 6-month follow-up examination after removal of the ePTFE . RESULTS At the 6-month follow-up examination , control and test groups showed significant improvement ; i.e. , reduction in the probing depth and increased clinical attachment gain compared with the values at the baseline examination . However , the mean clinical attachment gain of the test group ( 3.0+/-0.3 mm ) was significantly ( P = 0.03 ) greater than that of the control group ( 2.0+/-0.5 mm ) . Histologically , the total number of the cells of both groups was similar . In both groups , mononuclear cells were dominant and fibroblasts , neutrophils , and plasma cells were rarely encountered . There was a tendency for the number of macrophages to be somewhat higher in the control group . The total number of bacteria in the test group was significantly less than that in the control group . The number of bacteria in both control and test groups decreased toward the apical portion . CONCLUSIONS In the present study , clinical attachment gain of intrabony defects following GTR was favorable with repeated local administration of minocycline ointment . However , a complete microbial eradication was not achieved
In most respects , all membranes and enamel matrix derivative ( EMD ) delivered better outcomes , in the range of 1 to 2 mm , than open flap debridement .
The use of any barrier type or EMD configuration was found to yield more Clinical Attachment Level ( CAL ) gain than any open flap configuration .
GTR was confirmed to be superior to open flap debridement
In a 1998 review article , Laurell and colleagues performed a meta- analysis of relevant guided tissue regeneration ( GTR ) articles over the previous 20 years ( 1 ) .
The purpose of the present research was to exp and on that work , particularly search ing for trends discriminating between bioabsorbable and non-bioabsorbable barriers , as well as the use of enamel matrix derivative , with respect to interproximal bony defects .