SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .
Paroxetine in major depression: a double-blind trial with imipramine and placebo.
Paroxetine is a selective serotonin reuptake inhibitor which is being developed as an antidepressant . Previous studies suggest it is effective in the treatment of depression and has a low incidence of side effects . The authors report on a 6-week , r and omized , prospect i ve trial of paroxetine , imipramine , and placebo in 120 out patients with major depression . The results showed that paroxetine was significantly superior to placebo in relieving depression . There were no significant differences in antidepressant efficacy between paroxetine and imipramine . However , paroxetine was also significantly superior to placebo on several measures of anxiety . Imipramine either was not superior on these measures or took longer to show a significant difference . Paroxetine lacked the typical anticholinergic side effects that accompanied imipramine therapy . The results show that paroxetine is an effective antidepressant that may have value especially when depression is accompanied by significant anxiety
SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .