In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension.
The antihypertensive effect of crude stevioside obtained from the leaves of Stevia rebaudiana ( Bertoni ) Bertoni ( Compositae ) on previously untreated mild hypertensive patients was examined . Patients with essential hypertension were su bmi tted to a placebo phase for 4 weeks . The volunteers selected in this phase were r and omly assigned to receive either capsules containing placebo during 24 weeks or crude stevioside 3.75 mg/kg/day ( 7 weeks ) , 7.5 mg/kg/day ( 11 weeks ) and 15.0 mg/kg/day ( 6 weeks ) . All capsules were prescribed twice a daily ( b.i.d . ) , i.e. before lunch and before dinner . After the placebo phase and after each dose of crude stevioside , body mass index , electrocardiogram and laboratory tests were performed . During the investigation blood pressure ( BP ) was measured biweekly and the remaining data were collected at the end of each stevioside dose step . All adverse events were prospect ively recorded but no major adverse clinical effects were observed during the trial . Systolic and diastolic BP decreased ( p < 0.05 ) during the treatment with crude stevioside , but a similar effect was observed in the placebo group . Therefore , crude stevioside up to 15.0 mg/kg/day did not show an antihypertensive effect . Moreover , the results suggest that oral crude stevioside is safe and supports the well-established tolerability during long term use as a sweetener in Brazil
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .