Pooled evidence suggested that topical anaesthetic creams ( TAs ) , tramadol , selective serotonin reuptake inhibitors ( SSRIs ) , and phosphodiesterase type 5 inhibitors ( PDE5is ) are more effective at prolonging IELT comparing with placebo .
Conclusions We recommend the initial use of dapoxetine 30 mg OD for PE because it has been tested in largest and better design ed clinical trials rather than it is more effective than the other drugs studied .
TAs and tramadol 50 mg OD can be used as a viable alternative to oral treatment with SSRIs .
PDE5is combined with SSRIs are more effective than SSRIs monotherapy but are also associated with more side effects .
Purpose The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for  premature ejaculation ( PE ) .
Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation.
Premature ejaculation ( PE ) is the most common sexual disorder . It affects 20%-30 % of adult men ; the aetiology of this condition has not yet been eluci date d. The aim of this study is to evaluate the efficacy , safety , tolerability , undesirable effects and improved satisfaction with sexual intercourse with tramadol hydrochloride at different dosages for the treatment of PE . A total of 300 patients who presented with lifelong ( primary ) PE were included in this study . The study was performed for 28 weeks , in which placebo ( starch tablet ) was given for 4 weeks , and active ingredient ( tramadol hydrochloride ) was administered at different therapeutic dosages for 24 weeks . Patients were divided into three equal groups , each consisting of 100 patients . The first group ( A ) was given tramadol hydrochloride capsule 25 mg . The second group ( B ) was given tramadol hydrochloride capsule 50 mg . The third group ( C ) was given tramadol hydrochloride capsule 100 mg . All of the 300 participants included completed the study voluntarily . The age of the patients varied from 25 to 50 years . After the treatment period , the recorded data were collected for each group and analysed . The results showed a highly significant increase in the mean intravaginal ejaculatory latency time ( IELT ) in all groups compared to baseline data ( P<0.0001 ) . We concluded that using tramadol hydrochloride at different doses on dem and for the treatment of PE is effective , safe and tolerable , with minimal undesirable effects , and approval for this indication should be sought
Pooled evidence suggested that topical anaesthetic creams ( TAs ) , tramadol , selective serotonin reuptake inhibitors ( SSRIs ) , and phosphodiesterase type 5 inhibitors ( PDE5is ) are more effective at prolonging IELT comparing with placebo .
Conclusions We recommend the initial use of dapoxetine 30 mg OD for PE because it has been tested in largest and better design ed clinical trials rather than it is more effective than the other drugs studied .
TAs and tramadol 50 mg OD can be used as a viable alternative to oral treatment with SSRIs .
PDE5is combined with SSRIs are more effective than SSRIs monotherapy but are also associated with more side effects .
Purpose The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for  premature ejaculation ( PE ) .