Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .
Effect of Helicobacter pylori eradication therapy on dyspeptic symptoms in primary care.
OBJECTIVE The aim was to explore the effect of eradication therapy on dyspeptic symptoms in patients with known peptic ulcer disease ( PUD ) . METHOD A total of 164 known dyspeptics and 147 non-dyspeptic attenders at six UK general practice s were recruited . The Helisal Rapid Blood test was performed in the practice s and eradication therapy left to the preference of the general practitioner . Patients were followed prospect ively by a Likert scaled symptom question naire and record review . The symptom question naire distinguished between patients known to have dyspepsia and those not . RESULTS There was a statistically significant decrease in dyspeptic symptoms in patients with known PUD who received eradication therapy ( n = 43 , Z = -2.63 , P = 0.009 ) . CONCLUSIONS Eradication of Helicobacter pylori in primary care can lead to a reduction in consumption of H2 receptor antagonists and hence cost savings . This study demonstrates that dyspeptic symptoms also decrease . The question naire could be used in further studies to evaluate the effect of management on dyspeptic symptoms in the primary care setting
Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .