However , it can significantly decrease postintervention and reduction data of FPG , FI , HbA1c , and HOMA-IR .
Heterogeneity was eliminated by subgroup analysis according to baseline BMI .
There was no significant difference in the amelioration of QUICKI between the ITC and control groups .
However , the difference was statistically significant and the heterogeneity was eliminated after subgroup analysis according to intakes of ITC .
Conclusion Supplementation of ITC can ameliorate IR in T2DM , especially in obese T2DM patients , but the effects are controversial in obese patients
Background Insulin resistance ( IR ) is a physiological condition related to type 2 diabetes mellitus ( T2DM ) and obesity , which is associated with high blood insulin and glucose .
Inulin-type carbohydrate ( ITC ) is a kind of fermentable fructan that can reduce glucose and ameliorate IR in an animal model , but the effect in clinical trials is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of ITC supplementation in ameliorating IR in T2DM and obese patients .
Double blind randomized clinical trial controlled by placebo with a fos enriched cookie on saciety and cardiovascular risk factors in obese patients.
INTRODUCTION It is essential to determine which snack foods are most affective for appetite control . The objective of the current study was to assess the responses of two different cookies on satiety and cardiovascular risk factors . MATERIAL AND METHODS 38 patients were r and omized : group I ( FOS enriched cookie , n=19 ) and group II ( control cookie , n=19 ) . Previous and after 1 month , the subjects rated their feelings of satiety/hunger with a test meal of 5 cookies . RESULTS After the test meal , the basal area under curve of the first hunger/satiety score was higher with satiety cookie than with control cookie , the data after 1 month of treatment was higher with satiety cookie than with control cookie , too . The score was higher than the fasting level for 20 minutes with satiety cookie and for 40 minutes with the same cookie , too . In satiety group , these scores ( 20 min and 40 min ) were higher than control group before and after 1 month of treatment . The results were in the same way with the 100 mm 5-point visual satiety scale . Cardiovascular risk factors and dietary intake remained unchanged after dietary intervention . CONCLUSION A FOS enriched cookie produced greater ratings of satiety than a control cookie , without effects on cardiovascular risk factors or dietary intakes
However , it can significantly decrease postintervention and reduction data of FPG , FI , HbA1c , and HOMA-IR .
Heterogeneity was eliminated by subgroup analysis according to baseline BMI .
There was no significant difference in the amelioration of QUICKI between the ITC and control groups .
However , the difference was statistically significant and the heterogeneity was eliminated after subgroup analysis according to intakes of ITC .
Conclusion Supplementation of ITC can ameliorate IR in T2DM , especially in obese T2DM patients , but the effects are controversial in obese patients
Background Insulin resistance ( IR ) is a physiological condition related to type 2 diabetes mellitus ( T2DM ) and obesity , which is associated with high blood insulin and glucose .
Inulin-type carbohydrate ( ITC ) is a kind of fermentable fructan that can reduce glucose and ameliorate IR in an animal model , but the effect in clinical trials is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of ITC supplementation in ameliorating IR in T2DM and obese patients .