The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
The clinical effect of dentifrices containing stabilized stannous fluoride on plaque formation and gingivitis--a six-month study with ad libitum brushing.
The effects of stabilized 0.454 % stannous fluoride dentifrices on  supragingival plaque , gingival inflammation and gingival bleeding  were studied in 549 adult male and female subjects who completed a six-month , double blind clinical study . Following an oral prophylaxis , subjects were r and omly assigned to brush with one of the following dentifrices : 1 ) 0.454 % SnF2 stabilized with 2.08 % sodium gluconate , 2 ) 0.454 % SnF2 stabilized with 4.16 % sodium gluconate , 3 ) an experimental dentifrice , or 4 ) 0.243 % NaF control dentifrice . Follow-up examinations were conducted at 3 and 6 months . Compared to the control dentifrice at 6 months , stannous fluoride dentifrices stabilized with 2.08 % or 4.16 % sodium gluconate significantly reduced gingivitis by 18.8 % and 18.0 % , respectively . There were no statistically significant differences between the two stabilized SnF2 groups with respect to their beneficial effects on gingival health . Gingival bleeding was also reduced , relative to the control dentifrice , for both stabilized SnF2 dentifrices . However , these differences were not statistically significant at p=0.05 . The stabilized SnF2 dentifrices were not significantly different from the control dentifrice in their effects on supragingival plaque . No significant differences in adverse oral soft tissue effects were observed between the test and control groups . As expected , accumulation of extrinsic tooth stain increased in the stabilized SnF2 groups . However , the difficulty in removing accumulated dental stain was similar between the control and stabilized SnF2 dentifrices . Since use of SnF2 dentifrices has been reported to produce tooth stain , gingivitis examinations were done with and without custom-made tooth covers to evaluate the potential for examiner bias . Comparable gingivitis and gingival bleeding benefits were observed when the evaluations were conducted with or without the tooth covers . Results from this study support that 0.454 % stabilized stannous fluoride dentifrices can provide an important adjunct to the prevention and control of gingivitis when used in combination with regular personal oral hygiene procedures and professional care
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .