Results of r and omized controlled trials performed to date provide evidence that antibiotic prophylaxis reduces subsequent infection and that courses as short as one day are as effective as courses of three to five days , although the evidence warrants only low to moderate confidence .
BACKGROUND The purpose of the present study was to perform a systematic review and meta- analysis of the use of alternative antibiotic regimens-including ( A ) antibiotic prophylaxis versus no prophylaxis , ( B ) longer versus shorter duration of antibiotic prophylaxis , and ( C ) alternative drugs-for  patients with open fracture of the extremities .
Comparison the Efficacy of Cefazolin plus Gentamicin with Cefazolin plus Ciprofloxacin in Management of Type –IIIA Open Fractures
Background The optimal antibiotic regimen is still controversial in open fractures . The purpose of this study was to evaluate the efficacy of two different antibiotic regimens in management of type III-A open fractures . Methods From January 2001 to January 2008 , patients with type IIIA open fractures admitted in Shahid Beheshti Hospital Affiliated to Babol University of Medical Sciences were enrolled . Patients r and omly received cefazolin plus gentamicin ( group I ) or cefazolin plus ciprofloxacin ( group II ) . Both regimens were administered for 3 days . All patients were followed for 3 months . The efficacy of both regimens was compared . Results One hundred-forty eight and 153 patients were treated in group I and II , respectively . The mean age of the patients treated in group I was 36.96±14.4 and in group II was 36.93±13.51 years .  The rate of deep infection in group I was 5.4 % and in group II was 6.5 % . The efficacy of regimen I was 94.6 % and regimen II was 93.5 % . Conclusion Cefazolin plus gentamicin , or cefazolin plus ciprofloxacin both can be successfully used for prevention of infection in type IIIA open fractures
Results of r and omized controlled trials performed to date provide evidence that antibiotic prophylaxis reduces subsequent infection and that courses as short as one day are as effective as courses of three to five days , although the evidence warrants only low to moderate confidence .
BACKGROUND The purpose of the present study was to perform a systematic review and meta- analysis of the use of alternative antibiotic regimens-including ( A ) antibiotic prophylaxis versus no prophylaxis , ( B ) longer versus shorter duration of antibiotic prophylaxis , and ( C ) alternative drugs-for  patients with open fracture of the extremities .