However , benefit was limited to antipsychotics and tricyclic antidepressants .
Conclusions Psychotropic drugs may be an effective treatment for FD , but the effect appears to be limited to antipsychotics and tricyclic antidepressants with fewer trials for other agents , meaning that firm conclusions for efficacy can not be made .
Objective Functional dyspepsia ( FD ) is a chronic gastroduodenal disorder .
Individuals with FD demonstrate visceral hypersensitivity , abnormal central pain processing , and low mood , but it is unclear whether psychotropic drugs are an effective treatment for the condition .
Efficacy of the 5-HT1A Agonist Tandospirone Citrate in Improving Symptoms of Patients With Functional Dyspepsia: A Randomized Controlled Trial
OBJECTIVES : Functional dyspepsia ( FD ) is a common condition in the general population ; however , its treatment remains a challenge . The aim of this study was to examine the efficacy of t and ospirone citrate , a new partial agonist of the 5-hydroxytryptamine 1A ( 5-HT1A ) receptor , in improving the symptoms of patients with FD . METHODS : In this double-blind , placebo-controlled , multicenter study , FD patients were r and omized to treatment with 10 mg t.i.d . t and ospirone citrate or to placebo for 4 weeks . The primary end point was change in abdominal symptom scores . The difference in the proportion of responders ( a total abdominal symptom score of 0 or 1 ) was also assessed . The quality -of-life question naire , the SF-8 , and a psychological test question naire , the State-Trait Anxiety Inventory ( STAI ) , were completed at baseline and at weekly intervals . RESULTS : Data were available for 144 patients : 73 for t and ospirone and 71 for placebo .  Improvements in total abdominal scores were significantly larger with t and ospirone than placebo at weeks 1 , 2 , and 4 . Significantly greater improvements in the t and ospirone group were observed in upper abdominal pain ( P=0.02 ) and discomfort ( P=0.002 ) at week 4 . The proportion of responders was significantly greater in the active treatment arm at weeks 3 ( P=0.017 ) and 4 ( P=0.0016 ) . Significant improvements in STAI ( P<0.0001 ) were reported in both arms , as well as in the majority of questions in the SF-8 ( P=0.04 ) . No serious adverse events were reported , with similar rates in both study arms . CONCLUSIONS : Despite a considerable placebo effect , the benefits of t and ospirone were shown in terms of improvement in abdominal symptom scores
However , benefit was limited to antipsychotics and tricyclic antidepressants .
Conclusions Psychotropic drugs may be an effective treatment for FD , but the effect appears to be limited to antipsychotics and tricyclic antidepressants with fewer trials for other agents , meaning that firm conclusions for efficacy can not be made .
Objective Functional dyspepsia ( FD ) is a chronic gastroduodenal disorder .
Individuals with FD demonstrate visceral hypersensitivity , abnormal central pain processing , and low mood , but it is unclear whether psychotropic drugs are an effective treatment for the condition .