CONCLUSIONS This systematic review provides evidence for the efficacy of both SSRIs and TCAs in the treatment of chronic depression and showed a better acceptability of SSRIs
INTRODUCTION Chronic depression represents a substantial portion of depressive disorders and is associated with severe consequences .
This review examined the efficacy and acceptability of selective serotonin reuptake inhibitors ( SSRIs ) and tricyclic antidepressants ( TCAs ) in the treatment of chronic depression .
Additionally , the comparative effectiveness of the two types of antidepressants has been examined .
Long-term treatment of double depression: A preliminary study with serotonergic antidepressants
1 . There is increasing evidence that many patients with major depression also have coexisting dysthymia , and that antidepressant treatment may alleviate both conditions . 2 . Open-label study of fluoxetine and trazodone for 18 patients meeting DSM-III-R criteria for concurrent dysthymia and major depression . 3 . Fourteen patients completed three-month medication trials , and seven ( 50 % ) of completers ) responded to treatment . At five months , eight ( 57.1 % ) were in remission .  Fluoxetine was significantly better tolerated than trazodone , with respective dropout rates of 7.7 % and 80 % . 4 . Findings are consistent with efficacy of serotonergic agents in this condition
CONCLUSIONS This systematic review provides evidence for the efficacy of both SSRIs and TCAs in the treatment of chronic depression and showed a better acceptability of SSRIs
INTRODUCTION Chronic depression represents a substantial portion of depressive disorders and is associated with severe consequences .
This review examined the efficacy and acceptability of selective serotonin reuptake inhibitors ( SSRIs ) and tricyclic antidepressants ( TCAs ) in the treatment of chronic depression .
Additionally , the comparative effectiveness of the two types of antidepressants has been examined .