Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .
Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses?
Anecdotal and published case reports suggest that some patients taking selective serotonin reuptake inhibitors ( SSRI )  experience diminution in emotional responsiveness . This study aims to define the individual components of emotion disturbed in these patients . Fifteen patients reporting SSRI-induced sexual dysfunction completed the Laukes Emotional Intensity Scale  ( LEIS ) , a question naire about various emotions . Compared to controls , patients reported significantly ( p<0.05 ) less ability to cry , irritation , care about others ' feelings , sadness , erotic dreaming , creativity , surprise , anger , expression of their feelings , worry over things or situations , sexual pleasure , and interest in sex . Total score on the LEIS did not correlate with total score on the Hamilton Depression Rating Scale . In our sample , 80 % of patients with SSRI-induced sexual dysfunction also describe clinical ly significant blunting of several emotions . Emotional blunting may be an under-appreciated side-effect of SSRIs that may contribute to treatment non-compliance and /or reduced quality of life
Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .