The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .
The Protective Effects of α-Lipoic Acid on Kidneys in Type 2 Diabetic Goto-Kakisaki Rats via Reducing Oxidative Stress
To evaluate the protective effects of α-lipoic acid on the kidneys of Goto-Kakisaki ( GK ) diabetic rats , ten GK diabetic rats were r and omly divided into a diabetic control group and a lipoic acid-treated diabetic group with α-lipoic acid 35 mg·Kg−1 intraperitoneal injections . Four healthy Wistar rats served as normal controls . Malonaldehyde ( MDA ) , ascorbic acid ( vitamin C ) , vitamin E , glutathione ( GSH ) and superoxide dismutase ( SOD ) levels in renal homogenate , and urine protein excretion were measured . The expression of mRNA for NF-κB , NADPH oxidase subunits p22phox and p47phox in renal tissue was examined by realtime PCR . Pathological changes in renal tissue were evaluated by light and electron microscopy . There were significant increases in urine protein excretion , MDA levels and the expression of mRNA of NF-κB , p22phox and p47phox , and significant decreases in GSH , SOD , vitamin C and vitamin E levels in the diabetic control group compared with the normal control group . Pathological changes of renal tissue were more progressive in the diabetic control group than in the normal control group . All the parameters above were improved in the α-lipoic acid-treated diabetic group . Oxidative stress is increased in the kidney of type 2 diabetic GK rats . It is associated with the progression of diabetic nephropathy . α-lipoic acid can protect renal function in diabetic rats via its antioxidant activity
The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .