Among the outcomes examined , the highest absolute risk increase was for heart failure .
Associations between atrial fibrillation and included outcomes were broadly consistent across subgroups and in sensitivity analyses .
Atrial fibrillation is associated with an increased risk of death and an increased risk of cardiovascular and renal disease .
OBJECTIVE To quantify the association between  atrial fibrillation and cardiovascular disease , renal disease , and death .
Long-term outcomes after transcatheter aortic valve replacement in high-risk patients with severe aortic stenosis: the U.K. Transcatheter Aortic Valve Implantation Registry.
OBJECTIVES The U.K. Transcatheter Aortic Valve Implantation Registry reported 30-day and 1-year mortality rates of 7.1 % and 21.4 % , respectively , for patients who underwent transcatheter aortic valve replacement ( TAVR ) in the United Kingdom between 2007 and 2009 . The study aim was to report long-term outcomes in this same cohort of patients . BACKGROUND There are few data on outcomes beyond 3 years after TAVR in any notable number of patients . METHODS Data from all TAVR procedures performed in the United Kingdom between January 2007 and December 2009 were prospect ively collected . All-cause mortality status was reported in March 2014 . Mortality tracking was achieved in 97.7 % patients . RESULTS The minimal time from replacement to census was 4.1 years , and the maximal time was 7.0 years . The 3- and 5-year survival rates were 61.2 % and 45.5 % , respectively . Independent predictors of 3-year mortality were renal dysfunction ( hazard ratio [ HR ] : 1.65 ) , atrial fibrillation ( HR : 1.36 ) , logistic European System for Cardiac Operative Risk Evaluation ( EuroSCORE ) ≥18.5 ( HR : 1.33 ) , respiratory dysfunction ( HR : 1.28 ) , and ventricular dysfunction ( left ventricular ejection fraction < 30 % ) ( HR : 1.53 ) . Coronary artery disease ( HR : 1.28 ) and age ( HR : 1.03 ) were additional independent predictors of mortality at 5 years . Stroke within 30 days of TAVR was the only independent procedural predictor of mortality at 3 and 5 years ( HR : 2.17 at 3 years ) . Device type , access route , and paravalvular leak did not independently predict long-term outcome . CONCLUSIONS In the large U.K. Transcatheter Aortic Valve Implantation Registry , long-term outcomes after TAVR are favorable with 3- and 5-year survival rates of 61.2 % and 45.5 % , respectively . Long-term survival after TAVR is largely determined by intrinsic patient factors . Other than stroke , procedural variables , including paravalvular aortic leak , did not appear to be independent predictors of long-term survival
Among the outcomes examined , the highest absolute risk increase was for heart failure .
Associations between atrial fibrillation and included outcomes were broadly consistent across subgroups and in sensitivity analyses .
Atrial fibrillation is associated with an increased risk of death and an increased risk of cardiovascular and renal disease .
OBJECTIVE To quantify the association between  atrial fibrillation and cardiovascular disease , renal disease , and death .