In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients.
In vitro and in vivo animal studies have reported strong insulin-like or insulin-potentiating effects after cinnamon administration . Recently , a human intervention study showed that cinnamon supplementation ( 1 g/d ) strongly reduced fasting blood glucose concentration ( 30 % ) and improved the blood lipid profile in patients with type 2 diabetes . The objective of this study was to investigate the effects of cinnamon supplementation on insulin sensitivity and /or glucose tolerance and blood lipid profile in patients with type 2 diabetes . Therefore , a total of 25 postmenopausal patients with type 2 diabetes ( aged 62.9 + /- 1.5 y , BMI 30.4 + /- 0.9 kg/m2 ) participated in a 6-wk intervention during which they were supplemented with either cinnamon ( Cinnamomum cassia , 1.5 g/d ) or a placebo . Before and after 2 and 6 wk of supplementation , arterialized blood sample s were obtained and oral glucose tolerance tests were performed . Blood lipid profiles and multiple indices of whole-body insulin sensitivity were determined . There were no time x treatment interactions for whole-body insulin sensitivity or oral glucose tolerance . The blood lipid profile of fasting subjects did not change after cinnamon supplementation . We conclude that cinnamon supplementation ( 1.5 g/d ) does not improve whole-body insulin sensitivity or oral glucose tolerance and does not modulate blood lipid profile in postmenopausal patients with type 2 diabetes . More research on the proposed health benefits of cinnamon supplementation is warranted before health cl aims should be made
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .