None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .
ST-segment elevation resolution and outcome in patients treated with primary angioplasty and glucose-insulin-potassium infusion.
BACKGROUND To evaluate the impact of adjunctive high-dose glucose-insulin-potassium ( GIK ) on ST-segment elevation resolution in patients with ST-segment elevation myocardial infa rct ion ( MI ) . METHODS As part of a r and omized controlled trial of GIK versus no GIK in patients treated with primary percutaneous coronary intervention ( PCI ) for ST-elevation MI in a tertiary referral center , we analyzed ST-segment elevation resolution . Paired electrocardiographic recordings ( baseline and 3 hours after primary PCI ) were available in 612 ( 65 % ) of 940 patients . RESULTS We analyzed paired electrocardiograms of 310 patients r and omized to GIK and 302 control patients . Baseline characteristics of the groups were comparable . Combined complete ( > 70 % ) and partial ( 30%-70 % ) resolution was more commonly observed in the GIK group ( 87 % ) when compared with the control group ( 78 % ) , odds ratio 1.92 ( 95 % CI 1.23 - 3.02 , P = .004 ) ; 1-year mortality was lower in patients with combined complete and partial resolution compared with patients without resolution ( 3.8 % vs 10.3 % , P = .011 ) . There was no difference in 1-year mortality between GIK and control patients ( 5.5 % vs 4.3 % , P = .58 ) . CONCLUSIONS In patients with ST-elevation MI treated with primary PCI , addition of GIK is associated with improved ST-segment elevation resolution . ST-segment elevation resolution is related to improved 1-year survival . No benefit of GIK on 1-year outcome was observed . Future trials should investigate whether GIK-induced improvement of ST-segment elevation resolution results in more favorable clinical outcome
None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .