Our review revealed a great heterogeneity in definition , format , and values of what is considered a clinical ly relevant difference in pain in RCTs of analgesics , and st and ardizations are advisable
OBJECTIVE To describe the  pain decrease considered as clinical ly relevant when design ing a trial and reporting its results .
Intrauterine lignocaine as an anaesthetic during endometrial sampling: a randomised double-blind controlled trial.
OBJECTIVE To evaluate the effectiveness of intrauterine lignocaine as an anaesthetic during endometrial sampling . DESIGN Prospect i ve , r and omised , double-blind , placebo-controlled trial . SETTING Outpatient gynaecological minor operation unit in a public hospital . POPULATION Two hundred premenopausal women scheduled for endometrial sampling because of abnormal uterine bleeding . METHODS Transcervical intrauterine instillation of 5 mL of 2 % lignocaine or 5 mL of normal saline before performing endometrial sampling with vacuum aspirator . MAIN OUTCOME MEASURES Evaluation of pain associated with the procedure using a visual analogue scale . RESULTS The use of intrauterine lignocaine reduced pain during suction curettage in endometrial sampling . CONCLUSIONS Transcervical instillation of lignocaine reduced pain during endometrial sampling
Our review revealed a great heterogeneity in definition , format , and values of what is considered a clinical ly relevant difference in pain in RCTs of analgesics , and st and ardizations are advisable
OBJECTIVE To describe the  pain decrease considered as clinical ly relevant when design ing a trial and reporting its results .