There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Effect of omega 3 and omega 6 fatty acid intakes from diet and supplements on plasma fatty acid levels in the first 3 years of life.
BACKGROUND The optimal method for conducting omega (n-)3 polyunsaturated fatty acid ( PUFA ) supplementation trials in children is unknown . AIM To assess the impact of n-3 and n-6 PUFA intake from the background diet on plasma levels of n-3 and n-6 PUFA in children aged 0 - 3 years , with and without n-3 supplementation . METHODS Subjects were r and omised antenatally to receive either n-3 PUFA supplements and low n-6 PUFA cooking oils and spreads or a control intervention , design ed to maintain usual fatty acid intake . Dietary intake was assessed at 18 months by 3-day weighed food record and at 3 years by food frequency question naire . Plasma phospholipids were measured at both time points . Associations were tested by regression . RESULTS N-3 PUFA intake from background diet did not significantly affect plasma n-3 levels . In contrast , n-6 PUFA intake in background diet was positively related to plasma n-6 levels in both study groups . In addition , n-6 PUFA intake from diet was negatively associated with plasma n-3 levels at 18 months and 3 years ( -0.16%/g n-6 intake , 95%CI -0.29 to -0.03 and -0.05%/g n-6 intake , 95%CI -0.09 to -0.01 , respectively ) in the active group , but not in the control group . CONCLUSION Interventions intending to increase plasma n-3 PUFA in children by n-3 supplementation should also minimise n-6 PUFA intake in the background diet
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .