Other parameters under investigation were not affected by either low or high glycaemic indices .
The present systematic review and meta- analysis provides evidence of a beneficial effect of a low glycaemic index/load diet in children and adolescents being either overweight or obese .
The objective of the present systematic review and meta- analysis was to synthesize the available literature data investigating the effects of low glycaemic index/low glycamic load dietary regimens on anthropometric parameters , blood lipid profiles , and indicators of glucose metabolism in children and adolescents .
Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents.
OBJECTIVES To compare insulin sensitivity and pancreatic beta-cell function measured by the euglycemic and the hyperglycemic clamp , with simple estimates of insulin sensitivity and pancreatic beta-cell function in youth . Study design We measured insulin sensitivity with a euglycemic clamp and first- and second-phase insulin secretion with a hyperglycemic clamp in 156 AA and white youths . Estimates of insulin sensitivity ( fasting insulin level [ I(F ) ] , the ratio of fasting glucose [ G(F ) ] to I(F ) [ G(F)/I(F ) ] , homeostasis model assessment estimate of insulin sensitivity [ HOMA IS ] , and quantitative insulin sensitivity check index [ QUICKI ] ) and estimates of pancreatic beta-cell function ( I(F ) , the ratio of I(F ) to G(F ) [ I(F)/G(F ) ] , and homeostasis model assessment estimate of pancreatic beta-cell function [ HOMA % B ] ) were derived from fasting measurements . RESULTS In the total group , IS(Eu ) correlated strongly with I(F ) ( r=-0.92 ) , G(F)/I(F ) ( r=0.92 ) , HOMA IS ( r=0.91 ) , and QUICKI ( r=0.91 ) ( P<.01 ) . First-phase and second-phase insulin secretion correlated with I(F ) , I(F)/G(F ) , and HOMA % B ( first-phase insulin secretion : r=0.76 , 0.79 , 0.82 ; second-phase insulin secretion : r=0.83 , 0.86 , 0.86 , respectively ; P<.01 ) . CONCLUSIONS Simple estimates of insulin sensitivity and pancreatic beta-cell function using fasting insulin and glucose levels serve as surrogate measures of insulin sensitivity and secretion in nondiabetic youths . The validity of these conclusions in children with impaired glucose tolerance and type 2 diabetes mellitus remains to be determined
Other parameters under investigation were not affected by either low or high glycaemic indices .
The present systematic review and meta- analysis provides evidence of a beneficial effect of a low glycaemic index/load diet in children and adolescents being either overweight or obese .
The objective of the present systematic review and meta- analysis was to synthesize the available literature data investigating the effects of low glycaemic index/low glycamic load dietary regimens on anthropometric parameters , blood lipid profiles , and indicators of glucose metabolism in children and adolescents .