These studies demonstrated improvement in biochemical profiles , with a decline in or normalization of liver enzymes .
However , some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis .
There has been a growing interest in the role of vitamin E supplementation in the treatment and /or prevention of nonalcoholic fatty liver ( NAFLD ) .
Furthermore , histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only .
Intakes of magnesium, calcium and risk of fatty liver disease and prediabetes.
OBJECTIVE Obesity and insulin resistance play important roles in the pathogenesis of non-alcoholic fatty liver disease ( NAFLD ) . Mg intake is linked to a reduced risk of metabolic syndrome and insulin resistance ; people with NAFLD or alcoholic liver disease are at high risk of Mg deficiency . The present study aim ed to investigate whether Mg and Ca intakes were associated with risk of fatty liver disease and prediabetes by alcohol drinking status . DESIGN We analysed the association between  Ca or Mg intake and  fatty liver disease , prediabetes or both prediabetes and fatty liver disease in cross-sectional analyses . SETTING Third National Health and Nutrition Examination Survey ( NHANES III ) follow-up cohort of US adults . SUBJECTS Nationally representative sample of US adults in NHANES ( n 13 489 ) . RESULTS After adjusting for potential confounders , Mg intake was associated with approximately 30 % reduced odds of fatty liver disease and prediabetes , comparing the highest intake quartile v. the lowest . Mg intake may only be related to reduced odds of fatty liver disease and prediabetes in those whose Ca intake is less than 1200 mg/d . Mg intake may also only be associated with reduced odds of fatty liver disease among alcohol drinkers . CONCLUSIONS The study suggests that high intake of Mg may be associated with reduced risks of fatty liver disease and prediabetes . Further large studies , particularly prospect i ve cohort studies , are warranted to confirm the findings
These studies demonstrated improvement in biochemical profiles , with a decline in or normalization of liver enzymes .
However , some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis .
There has been a growing interest in the role of vitamin E supplementation in the treatment and /or prevention of nonalcoholic fatty liver ( NAFLD ) .
Furthermore , histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only .