Overall , a general lack of efficacy of SGAs on panic symptoms was observed .
Except for ziprasidone , SGAs were well tolerated in these short-term trials
A role for second-generation antipsychotics ( SGAs ) in the treatment of  panic disorders ( PD ) has been proposed , but the actual usefulness of SGAs in this disorder is unclear .
Bipolar disorder and panic disorder in families: an analysis of chromosome 18 data.
OBJECTIVE The authors performed an analysis of their published chromosome 18 linkage data on 28 families in which there was bipolar disorder to test the potential of comorbid panic disorder to define a genetic subtype of bipolar disorder . METHOD Families ascertained through prob and s with bipolar I disorder were stratified into three groups based on a history of panic disorder , panic attacks , or no panic attacks in the prob and s. Multipoint  nonparametric linkage analysis was performed on data from bipolar I and II family members in each group . RESULTS Linkage scores for five consecutive 18q marker loci were highest in the families of the prob and s with panic disorder and lowest for the families of the prob and s without panic attacks . CONCLUSIONS This study supports the authors ' previously reported clinical hypothesis of a genetic subtype of bipolar disorder identified by comorbid panic disorder . The hypothesis merits prospect i ve testing
Overall , a general lack of efficacy of SGAs on panic symptoms was observed .
Except for ziprasidone , SGAs were well tolerated in these short-term trials
A role for second-generation antipsychotics ( SGAs ) in the treatment of  panic disorders ( PD ) has been proposed , but the actual usefulness of SGAs in this disorder is unclear .