In the meta- analysis , tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates .
However , compared with sildenafil , tadalafil significantly improved psychological outcomes .
Furthermore , the patients and their partners preferred tadalafil over sildenafil , and no significant difference was found in the adherence and persistence rates between tadalafil and sildenafil .
Additionally , the myalgia and back pain rates were higher and the flushing rate was lower with tadalafil than with sildenafil .
Conclusion Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients ’ sexual confidence .
Furthermore , patients and their partners prefer tadalafil to sildenafil .
Hence , tadalafil may be a better choice for ED treatment
Aims Erectile dysfunction ( ED ) is a major care problem worldwide .
Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED .
This systematic review and meta- analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED .
EDITS: development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction.
OBJECTIVES To develop Patient and Partner versions of a psychometrically sound question naire , the EDITS ( Erectile Dysfunction Inventory of Treatment Satisfaction ) , to assess satisfaction with medical treatments for erectile dysfunction . METHODS Treatment satisfaction differs from treatment efficacy as it focuses on a person 's subjective evaluation of treatment received . Twenty-nine items representing the domain of treatment satisfaction for men and 20 representing partner satisfaction were generated . Two independent sample s of 28 and 29 couples completed all items at two points in time . Spearman rank-order correlations were derived to assess test-retest reliability and couple coefficients of validity . Internal consistency coefficients were calculated for both Patient and Partner versions and a content validity panel was used to analyze content validity . RESULTS Only items that met all the following criteria were selected to comprise the final question naires : ( a ) range of response four or more out of five ; ( b ) test-retest reliability greater than 0.70 ; ( c ) ratings by at least 70 % of the content validity panel as belonging in and being important for the domain ; and ( d ) significant correlation between the subjects ' and partners ' responses . Eleven patient items met criteria and formed the Patient EDITS ; five partner items met criteria and formed the Partner EDITS . Scores on the two inventories were normally distributed with internal consistencies of 0.90 and 0.76 , respectively . Test-retest reliability for the Patient EDITS was 0.98 ; for the Partner EDITS , it was 0.83 . CONCLUSIONS Reliability and validity were well established , enabling the EDITSs to be used to assess satisfaction with treatment modalities for erectile dysfunction and to explore the impact of patient and partner satisfaction on treatment continuation
In the meta- analysis , tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates .
However , compared with sildenafil , tadalafil significantly improved psychological outcomes .
Furthermore , the patients and their partners preferred tadalafil over sildenafil , and no significant difference was found in the adherence and persistence rates between tadalafil and sildenafil .
Additionally , the myalgia and back pain rates were higher and the flushing rate was lower with tadalafil than with sildenafil .
Conclusion Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients ’ sexual confidence .
Furthermore , patients and their partners prefer tadalafil to sildenafil .
Hence , tadalafil may be a better choice for ED treatment
Aims Erectile dysfunction ( ED ) is a major care problem worldwide .
Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED .
This systematic review and meta- analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED .