Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Skeletal muscle strength in young Asian Indian females after vitamin D and calcium supplementation: a double-blind randomized controlled clinical trial.
CONTEXT R and omized control trials ( RCT ) of the effect of vitamin D/calcium supplementation on skeletal muscle strength have not shown promising effect in the elderly . OBJECTIVE Our objective was to assess the effect of vitamin D and /or calcium on muscle strength in young adults with vitamin D deficiency . DESIGN AND SETTING We conducted a RCT using a factorial design at a tertiary-care center from September 2010 to April 2011 . SUBJECTS A total of 173 healthy females with mean age , body mass index , and 25-hydroxyvitamin D [ 25(OH)D ] of 21.7 ± 4.4 yr , 20.8 ± 2.96 kg/m(2 ) , and 9.3 ± 3.37 ng/ml , respectively , were block r and omized to 1 ) double placebo , 2 ) calcium/placebo , 3 ) cholecalciferol/placebo , and 4 ) cholecalciferol/calcium for 6 months . Cholecalciferol was given at 60,000 IU/wk for 8 wk followed by 60,000 IU/fortnight . Elemental calcium was given in doses of 500 mg twice per day for 6 months . METHODS Assessment included h and grip ( primary outcome ) and pinch grip strength , distance walked in 6 min , dyspnea score , quality of life by Short Form ( 36 ) Health Survey ( SP-36 ) , serum 25(OH)D , 1,25-dihydroxyvitamin D , and intact PTH . RESULTS The serum 25(OH)D increased significantly to 29.9 ± 8.35 and 27.0 ± 9.54 ng/ml in two groups on cholecalciferol . The mean h and grip strength ( 19.4 ± 3.92 , 21.1 ± 3.31 , 20.6 ± 3.92 , and 20.1 ± 4.00 kg ) and its increase from baseline ( 0.3 ± 2.25 , 0.3 ± 2.64 , -0.3 ± 2.41 , and 0.6 ± 2.30 kg ) were comparable in four groups at 6 months . Quality of life , urinary calcium/creatinine ratio , and adverse effects were also comparable in groups . CONCLUSION Oral cholecalciferol/calcium supplementation in the dose/schedule used is effective and safe in increasing and maintaining serum 25(OH)D. However , this does not lead to improved skeletal muscle strength in young females
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .