No evidence support the consumption of GT/GTE could reduce the levels of HbA1c , HOMA-IR , fasting insulin , or fasting glucose in people with pre-diabetes/T2DM .
Green tea or green tea extract ( GT/GTE ) has been demonstrated to reduce insulin resistance and improve glycemic control .
However , evidence for this health beneficial effect is inconsistent .
This systematic review evaluated the effect of GT/GTE on insulin resistance and glycemic control in people with pre-diabetes/type 2 diabetes mellitus ( T2DM ) .
EGCG-rich green tea extract stimulates sRAGE secretion to inhibit S100A12-RAGE axis through ADAM10-mediated ectodomain shedding of extracellular RAGE in type 2 diabetes.
The receptor for advanced glycation of end products ( RAGE ) plays a critical role in the progression of type 2 diabetes ( T2D ) . Soluble RAGE ( sRAGE ) is one of the RAGE variants , which acts as a decoy domain receptor and competes with RAGE , thus contributing to prevention of T2D . In this study , we conducted clinical trials of (-)-epigallocatechin-3-gallate ( EGCG ) rich green tea extract ( 300 - 900 mg/day ) to investigate the effect of EGCG on relationship between S100A12 RAGE lig and and diverse sRAGE in T2D . Moreover , mechanism of sRAGE production also confirmed in vitro . Our data indicated that EGCG could stimulate sRAGE circulation but inhibited RAGE lig and in T2D , and ADAM10-mediated ectodomain shedding of extracellular RAGE was mainly involved in EGCG-stimulated sRAGE circulation . The present evidence indicates that EGCG has a potential to block S100A12-RAGE axis by stimulating sRAGE production through ADAM10-mediated ectodomain shedding of extracellular RAGE . Therefore , EGCG contributes to nutritional strategies for diabetes , not only because of its efficient antioxidant activity to scavenge free radicals , but also because of its ability stimulating sRAGE release in the circulation . Additionally , ADAM10-induced ectodomain shedding of extracellular RAGE leading to sRAGE circulation should be a potential of passive mechanism of sRAGE production to block S100A12-RAGE axis-related pathogenesis of proinflammation and diabetes
No evidence support the consumption of GT/GTE could reduce the levels of HbA1c , HOMA-IR , fasting insulin , or fasting glucose in people with pre-diabetes/T2DM .
Green tea or green tea extract ( GT/GTE ) has been demonstrated to reduce insulin resistance and improve glycemic control .
However , evidence for this health beneficial effect is inconsistent .
This systematic review evaluated the effect of GT/GTE on insulin resistance and glycemic control in people with pre-diabetes/type 2 diabetes mellitus ( T2DM ) .