The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
Effect of a dentifrice containing triclosan and a copolymer on plaque formation and gingivitis.
A total of one hundred twenty-one ( 121 ) adult male and female subjects completed a 6-month , double-blind clinical study comparing the effect on supragingival plaque formation and gingivitis of a dentifrice containing 0.3 % Triclosan and 2.0 % of a copolymer of methoxyethylene and maleic acid to a placebo dentifrice . Both the Triclosan/copolymer and placebo dentifrices contained 0.243 % sodium fluoride in a silica base . Subjects were stratified into two balanced groups according to baseline plaque and gingivitis scores . They then received an oral prophylaxis and were assigned to use either the Triclosan/copolymer dentrifrice or the placebo dentifrice for the next 6 months . Subjects were evaluated for supragingival plaque formation and gingivitis after 3 and 6 months ' use of the dentifrices . After 6 months , the Triclosan/copolymer dentifrice was shown to provide a 32.32 % statistically significant reduction ( 99 % level of confidence ) in supragingival plaque formation , as compared to the placebo dentifrice . Also , after 6 months , the Triclosan/copolymer dentifrice was shown to provide a 25.64 % statistically significant reduction ( 99 % level of confidence ) in gingivitis , as compared to the placebo dentifrice . It thus can be concluded from this clinical study that the twice daily use of the dentifrice containing 0.3 % Triclosan and 2.0 % of a copolymer in a 0.243 % sodium fluoride/silica base provides statistically significant reductions in both supragingival plaque formation and gingivitis
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .