Findings are subject to incomplete reporting and heterogeneity of studies included , and confounding because most included studies used pre-post study design s. CONCLUSIONS DPP lifestyle modification programs achieved clinical ly meaningful weight and cardiometabolic health improvements .
Together , these data suggest that additional value is gained from these programs , reinforcing that they are likely very cost-effective
BACKGROUND The Diabetes Prevention Program ( DPP ) study showed that weight loss in high-risk adults lowered diabetes incidence and cardiovascular disease risk .
No prior analyses have aggregated weight and cardiometabolic risk factor changes observed in studies implementing DPP interventions in non research setting s in the United States .
A Randomized Comparative Effectiveness Trial for Preventing Type 2 Diabetes.
OBJECTIVES We evaluated the weight loss effectiveness of a YMCA model for the Diabetes Prevention Program ( DPP ) lifestyle intervention . METHODS Between July 2008 and November 2010 , we individually r and omized 509 overweight or obese , low-income , nondiabetic adults with elevated blood glucose in Indianapolis , Indiana , to receive st and ard care plus brief lifestyle counseling or be offered a group-based YMCA adaptation of the DPP ( YDPP ) . Primary outcome was mean weight loss difference at 12 months . In our intention-to-treat analyses , we used longitudinal linear or logistic regression , multiply imputing missing observations . We used instrumental variables regression to estimate weight loss effectiveness among participants completing 9 or more intervention lessons . RESULTS In the YDPP arm , 161 ( 62.6 % ) participants attended ≥ 1 lesson and 103 ( 40.0 % ) completed 9 or more lessons . In intention-to-treat analysis , mean 12-month weight loss was 2.3 kilograms ( 95 % confidence interval [ CI ] = 1.1 , 3.4 kg ) more for the YDPP arm than for st and ard care participants . In instrumental variable analyses , persons attending 9 or more lessons had a 5.3-kilogram ( 95 % CI = 2.8 , 7.9 kg ) greater weight loss than did those with st and ard care alone . CONCLUSIONS The YMCA model for DPP delivery achieves meaningful weight loss at 12 months among low-income adults
Findings are subject to incomplete reporting and heterogeneity of studies included , and confounding because most included studies used pre-post study design s. CONCLUSIONS DPP lifestyle modification programs achieved clinical ly meaningful weight and cardiometabolic health improvements .
Together , these data suggest that additional value is gained from these programs , reinforcing that they are likely very cost-effective
BACKGROUND The Diabetes Prevention Program ( DPP ) study showed that weight loss in high-risk adults lowered diabetes incidence and cardiovascular disease risk .
No prior analyses have aggregated weight and cardiometabolic risk factor changes observed in studies implementing DPP interventions in non research setting s in the United States .