Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .
Effectiveness of Prophylactic Antibiotics in a Population-Based Cohort of Patients Undergoing Planned Cholecystectomy
Background In the absence of r and omized controlled trials with sufficient power to assess the effectiveness of prophylactic antibiotics ( PA ) , the best evidence is provided by large population -based register studies . Methods The Swedish Register of Gallstone Surgery and ERCP ( GallRiks ) started in May 2005 and reached 75 % national coverage in 2007 . During 2006 and 2007 , a total of 16,400 operations were registered in GallRiks . In the present study , all elective procedures performed in 2006–2007 in units performing at least 25 operations annually were included in an analysis of the risk for postoperative infectious complications Results Altogether 10,927 procedures were performed 2006–2007 .  Univariate logistic regression analysis revealed a paradoxical increase in postoperative infectious complications requiring antibiotic treatment and postoperative abscess if PA were given ( p < 0.05 ) . This increase disappeared in multivariate analysis with adjustment for age , gender , presence of cholecystitis , accidental gallbladder perforation , and presence of bile duct stones . Conclusion No benefit from PA was seen in this study on elective cholecystectomy . Although a r and omized controlled trial could possibly show a reduction in the risk for postoperative infectious complications not detected in this study , such a reduction must be weighed against the risk of promoting drug resistance by the widespread use of PA
Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .