This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .
Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.
BACKGROUND Common genetic variants in the insulin receptor substrate 1 ( IRS1 ) gene have been recently associated with insulin resistance and hyperinsulinemia . We examined whether the best-associated variant modifies the long-term changes in insulin resistance and body weight in response to weight-loss diets in Preventing Overweight Using Novel Dietary Strategies ( POUNDS LOST ) trial . METHODS AND RESULTS We genotyped IRS1 rs2943641 in 738 overweight adults ( 61 % were women ) who were r and omly assigned to 1 of 4 diets varying in macronutrient contents for 2 years . We assessed the progress in fasting insulin , homeostasis model assessment of insulin resistance ( HOMA-IR ) and weight loss by genotypes . At 6 months , participants with the risk-conferring CC genotype had greater decreases in insulin ( P=0.009 ) , HOMA-IR ( P=0.015 ) , and weight loss ( P=0.018 ) than those without this genotype in the highest-carbohydrate diet group whereas an opposite genotype effect on changes in insulin and HOMA-IR ( P≤0.05 ) was observed in participants assigned to the lowest-carbohydrate diet group . No significant differences were observed across genotypes in the other 2 diet groups . The tests for genotype by intervention interactions were all significant ( P<0.05 ) . At 2 years , the genotype effect on changes in insulin and HOMA-IR remained significant in the highest-carbohydrate diet group ( P<0.05 ) . The highest carbohydrate diet led to a greater improvement of insulin and HOMA-IR ( P for genotype-time interaction ≤0.009 ) in participants with the CC genotype than those without this genotype across 2-year intervention . CONCLUSIONS Individuals with the IRS1 rs2943641 CC genotype might obtain more benefits in weight loss and improvement of insulin resistance than those without this genotype by choosing a high-carbohydrate and low-fat diet . CLINICAL TRIAL REGISTRATION http : www . clinical trials.gov . Unique identifier : NCT00072995
This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .