Insulin mediated inhibition of lipolysis was decreased in patients , reflected by increased non-esterified fatty acid levels .
Insulin resistance is a prominent feature of patients with type 1 diabetes mellitus and involves hepatic , peripheral and adipose tissues
OBJECTIVE The aim of this study was to perform a systematic review and meta- analysis on insulin resistance in adult patients with type 1 diabetes mellitus compared to healthy controls , assessed by hyperinsulinemic euglycemic clamp studies .
Femoral-gluteal adiposity is not associated with insulin sensitivity in type 1 diabetes.
AIMS To quantify and compare associations between femoral-gluteal adiposity and insulin sensitivity in adults with Type 1 diabetes mellitus with adults with normal glucose tolerance . METHODS Individuals with Type 1 diabetes ( n = 28 ) were recruited from the Pittsburgh Epidemiology of Diabetes Complication study , a 24-year prospect i ve study of childhood-onset diabetes , and compared cross-sectionally with individuals with normal glucose tolerance ( n = 56 ) of similar age , sex and BMI . Insulin sensitivity was defined as whole-body glucose disposal measured by hyperinsulinaemic-euglycaemic clamps . Adiposity was quantified by dual energy X-ray absorptiometry . RESULTS Individuals with Type 1 diabetes exhibited lower insulin sensitivity ( 5.8 vs. 8.2 mg min(-1 ) kg fat-free mass(-1 ) , P < 0.01 ) , lower total fat mass ( 20.1 vs. 29.0 kg , P < 0.001 ) and lower proportional leg fat mass ( 36.0 vs.37.7 % , P = 0.03 ) , but similar proportional trunk fat ( % trunk fat mass ) compared with individuals with normal glucose tolerance . Overall , results from linear regression demonstrated that higher % leg fat mass ( P < 0.01 ) and lower % trunk fat mass ( P < 0.01 ) were independently associated with lower insulin sensitivity after adjustments for age , sex , height , total fat mass ( kg ) and diabetes status . Higher % leg fat mass was independently associated with higher insulin sensitivity in individuals with normal glucose tolerance ( P < 0.01 ) after similar adjustment ; significant associations were not observed in Type 1 diabetes . CONCLUSIONS Reduced insulin sensitivity is a prominent feature of Type 1 diabetes and is associated with total and abdominal adiposity . Compared with adults with normal glucose tolerance , leg fat mass does not show any positive association with insulin sensitivity in Type 1 diabetes
Insulin mediated inhibition of lipolysis was decreased in patients , reflected by increased non-esterified fatty acid levels .
Insulin resistance is a prominent feature of patients with type 1 diabetes mellitus and involves hepatic , peripheral and adipose tissues
OBJECTIVE The aim of this study was to perform a systematic review and meta- analysis on insulin resistance in adult patients with type 1 diabetes mellitus compared to healthy controls , assessed by hyperinsulinemic euglycemic clamp studies .