RESULTS Weight loss was associated with a decline in CRP level .
Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level
BACKGROUND Several studies suggest that weight loss reduces C-reactive protein ( CRP ) level ; however , the consistency and magnitude of this effect has not been well characterized .
Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level .
Glycemic control and coronary heart disease risk in persons with and without diabetes: the atherosclerosis risk in communities study.
BACKGROUND Chronic hyperglycemia has been hypothesized to contribute to coronary heart disease ( CHD ) , but the extent to which hemoglobin A(1c ) ( HbA(1c ) ) level , a marker of long-term glycemic control , is independently related to CHD risk is uncertain . METHODS We conducted a prospect i ve case-cohort study of 1321 adults without diabetes and a cohort study of 1626 adults with diabetes from the Atherosclerosis Risk in Communities Study . Using proportional hazards models , we assessed the relation between HbA(1c ) level and incident CHD during 8 to 10 years of follow-up . RESULTS In adults with diabetes , the relative risk ( RR ) of CHD was 2.37 ( 95 % confidence interval [ CI ] , 1.50 - 3.72 ) for the highest quintile of HbA(1c ) level compared with the lowest after adjustment for CHD risk factors . In persons without diabetes , the adjusted RR of CHD in the highest quintile of HbA(1c ) level was 1.41 ( 95 % CI , 0.90 - 2.30 ) ; however , there was evidence of a nonlinear relationship in this group . In nondiabetic adults , HbA(1c ) level was not related to CHD risk below a level of 4.6 % but was significantly related to risk above that level ( P<.001 ) . In diabetic adults , the risk of CHD increased throughout the range of HbA(1c ) levels . In the adjusted model , the RR of CHD for a 1-percentage point increase in HbA(1c ) level was 2.36 ( 95 % CI , 1.43 - 3.90 ) in persons without diabetes but with an HbA(1c ) level greater than 4.6 % . In diabetic adults , the RR was 1.14 ( 95 % CI , 1.07 - 1.21 ) per 1-percentage point increase in HbA(1c ) across the full range of HbA(1c ) values . CONCLUSION Elevated HbA(1c ) level is an independent risk factor for CHD in persons with and without diabetes
RESULTS Weight loss was associated with a decline in CRP level .
Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level
BACKGROUND Several studies suggest that weight loss reduces C-reactive protein ( CRP ) level ; however , the consistency and magnitude of this effect has not been well characterized .
Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level .