This meta- analysis uncovered clinical ly improved effects of yoga intervention on glycemic control , lipid profiles and other parameters of T2DM management in prediabetic population .
These results suggest that yoga intervention may be considered as a comprehensive and alternative approach to preventing T2DM .
A systematic review and meta- analysis was conducted to investigate the effects of yoga on glycemic control , lipid profiles , body composition and blood pressure in people in the pre-diabetic state .
Effect of aspirin on renal disease progression in patients with type 2 diabetes: A multicenter, double-blind, placebo-controlled, randomized trial. The renaL disEase progression by aspirin in diabetic pAtients (LEDA) trial. Rationale and study design.
Type 2 diabetes mellitus ( T2DM ) is one of the most common causes of chronic kidney disease and kidney failure . It has been estimated that the annual decline of estimated glomerular filtration rate ( eGFR ) among patients with T2DM is approximately 2.0 - 2.5mL min-1 y-1 . Cyclooxygenase-dependent eicosanoids , such as 11-dehydro-thromboxane (Tx)B2 , are increased in T2DM patients and are potentially involved in the regulation of renal blood flow . Animal models showed that cyclooxygenase inhibitors , such as aspirin , are associated with improvements in renal plasma flow and eGFR values . HYPOTHESIS The primary end point of the LEDA trial is to evaluate the 1-year decline of eGFR in T2DM patients treated or not with low-dose aspirin ( 100mg/d ) . Secondary end points will be the rapid decline in renal function , defined as a reduction of eGFR ≥5mL/min , and change of renal function class after 1-year follow-up . Furthermore , urinary excretion 11-dehydro-TxB2 will be related to renal function modifications . STUDY DESIGN A phase 3 no-profit , multicenter , double-blind , r and omized intervention trial of aspirin 100mg/dvs placebo ( Clinical Trials.gov Identifier : NCT02895113 ) . All patients will be monitored at 6 and 12months after r and omization to assess drug adherence and eGFR changes . SUMMARY The LEDA trial is the first double-blind , placebo-controlled , r and omized clinical trial aim ed at examining whether aspirin treatment may beneficially affect kidney function in patients with T2DM by reducing the annual eGFR decline . The trial will also examine whether the potential renoprotective effects of aspirin might be partly due to its inhibition of TxB2 production
This meta- analysis uncovered clinical ly improved effects of yoga intervention on glycemic control , lipid profiles and other parameters of T2DM management in prediabetic population .
These results suggest that yoga intervention may be considered as a comprehensive and alternative approach to preventing T2DM .
A systematic review and meta- analysis was conducted to investigate the effects of yoga on glycemic control , lipid profiles , body composition and blood pressure in people in the pre-diabetic state .