The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .
C-reactive protein as early predictor for infectious postoperative complications in rectal surgery
Background This study evaluated the role of the acute phase C-reactive protein ( CRP ) in the postoperative course of a large series of rectal resections on the basis of a prospect i ve data base . Main focus of this study was the early identification of complications . Material s and methods Three hundred eighty-three rectal resections with primary anastomosis for rectal cancer were screened for infectious postoperative complications . Forty-eight complicated cases were identified and matched with 48 patients with an uneventful postoperative course . Results In the postoperative setting , CRP peaked on postoperative day ( POD ) 2 with a median serum CRP of 140 mg/l and gradually declined thereafter in uncomplicated cases . In complicated cases , CRP elevation generally persisted after POD 2 , whereas white blood cells and body temperature were within normal range in the early postoperative period . A cutoff CRP value of 140 mg/dl on PODs 3 and 4 result ed in predictive values of 85.7 and 90.5 % ( adjusted to the prevalence : 37.6 and 50.3 % ) , sensitivities of 80.0 and 54.3 % , and specificities of 81.0 and 92.3 % for a complicated postoperative course ( P < 0.001 ) , respectively . Conclusion Persistent CRP elevation and elevation of serum CRP  above 140 mg/dl on PODs 3–4 are predictive of infectious postoperative complications and should prompt intense clinical search for an inflammatory process , especially for an anastomotic leak if pneumonia and wound infection are unlikely or excluded
The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .