After the acute phase treatment , as long as the drug was continued , the superiority of the combination over either monotherapy appeared to persist .
BACKGROUND Panic disorder can be treated with pharmacotherapy , psychotherapy or in combination , but the relative merits of combined therapy have not been well established .
OBJECTIVES To review evidence concerning short- and long-term advantages and disadvantages of combined psychotherapy plus antidepressant treatment for panic disorder with or without agoraphobia , in comparison with either therapy alone .
Pretreatment attrition in a comparative treatment outcome study on panic disorder.
OBJECTIVE Whereas the fact of attrition during the course of treatment is well documented , little is known about the factors that affect sample selection before the beginning of a study ( " pretreatment attrition " ) . The present study reports on the degree and sources of pretreatment attrition at two sites of a multicenter study on panic disorder that compared treatment outcomes for imipramine and cognitive behavior therapy . METHOD Data were collected at two clinical research sites , one with a pharmacological treatment orientation ( N = 420 ) and one with a psychosocial treatment orientation ( N = 208 ) . RESULTS The main source of pretreatment attrition was participant refusal . At both research sites , eligible patients most often refused participation because they were either unwilling to start treatment with imipramine ( 30.6 % and 47.4 % , respectively ) or discontinue their current medication ( 22.6 % and 35.1 % , respectively ) . CONCLUSIONS Results from comparative treatment outcome studies are limited not only to people who meet the study criteria but also to those who are willing to begin a medication treatment and discontinue their current medication
After the acute phase treatment , as long as the drug was continued , the superiority of the combination over either monotherapy appeared to persist .
BACKGROUND Panic disorder can be treated with pharmacotherapy , psychotherapy or in combination , but the relative merits of combined therapy have not been well established .
OBJECTIVES To review evidence concerning short- and long-term advantages and disadvantages of combined psychotherapy plus antidepressant treatment for panic disorder with or without agoraphobia , in comparison with either therapy alone .