In both rodent and cell culture models , CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus .
In rodent models , CBD was found to attenuate alcohol-induced hepatotoxicity , specifically , alcohol-induced steatosis .
Finally , findings from pre clinical rodent models also indicate that CBD attenuates cue-elicited and stress-elicited alcohol seeking , alcohol self-administration , withdrawal-induced convulsions , and impulsive discounting of delayed rewards .
In human studies , CBD was well tolerated and did not interact with the subjective effects of alcohol .
Collectively , given its favorable effects on alcohol-related harms and addiction phenotypes in pre clinical models , CBD appears to have promise as a c and i date AUD pharmacotherapy .
This is further bolstered by the absence of abuse liability and its general tolerability .
There is substantial interest in the therapeutic potential of cannabidiol ( CBD ) , a nonpsychoactive cannabinoid found in plants of the genus Cannabis .
The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a c and i date pharmacotherapy for alcohol use disorder ( AUD ) .
Open Label Trial of the Tolerability and Efficacy of Zonisamide in the Treatment of Alcohol Dependence
Objectives : The objectives of this study are to assess the tolerability and efficacy of the anticonvulsant  zonisamide in an open label trial of the treatment of alcohol dependence . Methods : In this trial , zonisamide ( 400-mg daily ) was administered to alcohol-dependent subjects ( ADS ) ( n = 16 ) over 13 weeks . The mean daily consumption of st and ard alcoholic drinks and performance on a verbal fluency task , the COWAT , and on a measure of attention and visuomotor speed , the DSMT were assessed , and the occurrence of adverse events was monitored weekly . Results : The mean number of drinks consumed daily was significantly reduced from baseline levels during the treatment period . Performances on the COWAT and on the DSMT were not significantly reduced by zonisamide treatment . Overall , zonisamide was well tolerated by the study subjects . Conclusion : These results indicate that zonisamide administration may not impair verbal fluency in ADS , and are consistent with other studies that found zonisamide administration may reduce alcohol intake
In both rodent and cell culture models , CBD was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus .
In rodent models , CBD was found to attenuate alcohol-induced hepatotoxicity , specifically , alcohol-induced steatosis .
Finally , findings from pre clinical rodent models also indicate that CBD attenuates cue-elicited and stress-elicited alcohol seeking , alcohol self-administration , withdrawal-induced convulsions , and impulsive discounting of delayed rewards .
In human studies , CBD was well tolerated and did not interact with the subjective effects of alcohol .
Collectively , given its favorable effects on alcohol-related harms and addiction phenotypes in pre clinical models , CBD appears to have promise as a c and i date AUD pharmacotherapy .
This is further bolstered by the absence of abuse liability and its general tolerability .
There is substantial interest in the therapeutic potential of cannabidiol ( CBD ) , a nonpsychoactive cannabinoid found in plants of the genus Cannabis .
The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a c and i date pharmacotherapy for alcohol use disorder ( AUD ) .