Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .
Non-ulcer dyspepsia and short term De-Nol therapy: a placebo controlled trial with particular reference to the role of Campylobacter pylori.
This double blind r and omised study tested the effectiveness of colloidal bismuth subcitrate ( De-Nol ) in non-ulcer dyspepsia ( NUD ) and if any benefit is associated with clearance of Campylobacter pylori ( C pylori ) from the gastric mucosa . Sixty six patients with dyspepsic symptoms , normal abdominal ultrasound , and upper GI endoscopy , were r and omly allocated to placebo or De-Nol for eight weeks . Antral biopsies were taken for bacteriological and histological examination , and endoscopies and clinical question naires were administered before and after treatment . Fifty two patients ( 25 on De-Nol and 27 on placebo ) completed the trial .  De-Nol  cleared C pylori from 10 of the 12 C pylori positive patients ( 83.3 % ) , whereas placebo did not clear C pylori from any of the eight C pylori positive patients ( p less than 0.01 ) . In patients receiving De-Nol  gastritis improved ( p less than 0.01 ) and symptomatic response was better ( p less than 0.001 ) compared with placebo . In the placebo group seven of the 19 C pylori negative patients became positive : this was associated with significant deterioration of symptoms , a phenomenon not seen in the De-Nol treated group
Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .