We conclude that resveratrol does not change lipid profile concentration .
A : Meta‐ analysis of the effect of resveratrol supplementation on total cholesterol .
B : Meta‐ analysis of the effect of resveratrol supplementation on low‐density lipoprotein .
C : Meta‐ analysis of the effect of resveratrol supplementation on high‐density lipoprotein .
D : Meta‐ analysis of the effect of resveratrol supplementation on triglyceride after removing the study by Zortea et al. & NA ; Despite the notion that resveratrol can significantly reduce plasma lipids , the result of r and omized clinical trials ( RCTs ) on resveratrol effect and the serum lipid profile are contradictory .
Our objective was to conduct a systematic review and meta‐ analysis on r and omized clinical trials ( RCTs ) and assess the effect of resveratrol on lipids .
Absorption of three wine-related polyphenols in three different matrices by healthy subjects.
BACKGROUND Despite their powerful biologic activities conducive to protection against atherosclerosis , cancer and inflammatory diseases demonstrated in vitro , there is considerable doubt whether the polyphenolic constituents present in red wine and other dietary components are effective in vivo . OBJECTIVE We have tested the absorptive efficiency of three of these constituents ( trans-resveratrol , [+]-catechin and quercetin ) when given orally to healthy human subjects in three different media . DESIGN Twelve healthy males aged 25 to 45 were r and omly assigned to three different groups consuming orally one of the following polyphenols : trans-resveratrol , 25 mg/70 kg ; [+]-catechin 25 mg/70 kg ; quercetin 10 mg/70 kg . Each polyphenol was r and omly administered at 4-week intervals in three different matrices : white wine ( 11.5 % ethanol ) , grape juice , and vegetable juice/homogenate . Blood was collected at zero time and at four intervals over the first four hours after consumption ; urine was collected at zero time and for the following 24-h . The sums of free and conjugated polyphenols were measured in blood serum and urine by a gas-chromatographic method . RESULTS All three polyphenols were present in serum and urine predominantly as glucuronide and sulfate conjugates , reaching peak concentrations in the former around 30-min after consumption . The free polyphenols accounted for 1.7 to 1.9 % ( trans-resveratrol ) , 1.1 to 6.5 % ( [+]-catechin ) and 17.2 to 26.9 % ( quercetin ) of the peak serum concentrations . The absorption of trans-resveratrol was the most efficient as judged by peak serum concentration , area-under-the curve ( 4 h ) and urinary 24-h excretion ( 16 - 17 % of dose consumed ) . [+]-Catechin was the poorest by these criteria ( urine 24-h excretion 1.2%-3.0 % of dose consumed ) , with quercetin being intermediate ( urine 24-h excretion 2.9%-7.0 % of dose consumed ) . Some significant matrix effects were observed for the serum polyphenol concentrations , but in the case of urine no matrix promoted significantly higher excretion than the other two . CONCLUSIONS The absorption of these three polyphenols is broadly equivalent in aqueous and alcoholic matrices but , at peak concentrations of 10 to 40 nmol/L , is inadequate to permit circulating concentrations of 5 to 100 micromol/L consistent with in vitro biologic activity . The voluminous literature reporting powerful in vitro anticancer and antiinflammatory effects of the free polyphenols is irrelevant , given that they are absorbed as conjugates
We conclude that resveratrol does not change lipid profile concentration .
A : Meta‐ analysis of the effect of resveratrol supplementation on total cholesterol .
B : Meta‐ analysis of the effect of resveratrol supplementation on low‐density lipoprotein .
C : Meta‐ analysis of the effect of resveratrol supplementation on high‐density lipoprotein .
D : Meta‐ analysis of the effect of resveratrol supplementation on triglyceride after removing the study by Zortea et al. & NA ; Despite the notion that resveratrol can significantly reduce plasma lipids , the result of r and omized clinical trials ( RCTs ) on resveratrol effect and the serum lipid profile are contradictory .
Our objective was to conduct a systematic review and meta‐ analysis on r and omized clinical trials ( RCTs ) and assess the effect of resveratrol on lipids .