Azapirones may be less effective than benzodiazepines and we were unable to conclude if azapirones were superior to antidepressants , kava kava or psychotherapy .
Azapirones appeared to be well tolerated .
Azapirones appeared to be useful in the treatment of GAD , particularly for those participants who had not been on a benzodiazepine .
Azapirones may not be superior to benzodiazepines and do not appear as acceptable as benzodiazepines .
Side effects appeared mild and non serious in the azapirone treated group .
Longer term studies are needed to show that azapirones are effective in treating GAD , which is a chronic long-term illness
BACKGROUND Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from generalized anxiety disorder ( GAD ) .
However , several studies have shown conflicting results .
Whether azapirones are useful as first line treatment in general anxiety disorders still needs to be answered .
OBJECTIVES To assess the efficacy and the acceptability of azapirones for the treatment of GAD .
Evaluation of Buspirone as an Antianxiety Agent: Buspirone and Diazepam versus Placebo*
Buspirone has previously been demonstrated to be efficacious in the treatment of anxiety . This four-week double-blind parallel study compared buspirone to diazepam and placebo in the treatment of 119 out patients diagnosed as having generalized anxiety disorder . After a seven-day placebo washout period , eligible patients were r and omized to one of three treatment groups . Buspirone ( 5 mg ) and diazepam ( 5 mg ) were administered BID and individually titrated to an optimal therapeutic dose by the end of week two . Buspirone and diazepam were equally effective in reducing Hamilton Anxiety ( HAM-A ) total and psychic factor scores from baseline values . Buspirone alone was significantly better than plecebo in reducing the HAM-A somatic factor score . Sixty-seven percent of both active treatment groups who were classified as “ ill ” on the baseline global psychopathology rating scale achieved a “ not ill ” status by study end . There were no significant differences between treatment groups at endpoint on the 56-item Symptom Checklist self-rating scale .  Buspirone was demonstrated to be as effective as diazepam in relieving anxiety in this outpatient sample
Azapirones may be less effective than benzodiazepines and we were unable to conclude if azapirones were superior to antidepressants , kava kava or psychotherapy .
Azapirones appeared to be well tolerated .
Azapirones appeared to be useful in the treatment of GAD , particularly for those participants who had not been on a benzodiazepine .
Azapirones may not be superior to benzodiazepines and do not appear as acceptable as benzodiazepines .
Side effects appeared mild and non serious in the azapirone treated group .
Longer term studies are needed to show that azapirones are effective in treating GAD , which is a chronic long-term illness
BACKGROUND Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from generalized anxiety disorder ( GAD ) .
However , several studies have shown conflicting results .
Whether azapirones are useful as first line treatment in general anxiety disorders still needs to be answered .
OBJECTIVES To assess the efficacy and the acceptability of azapirones for the treatment of GAD .