The antihypertensive efficacy of HCTZ in its daily dose of 12.5 to 25 mg as measured in head-to-head studies by ambulatory BP measurement is consistently inferior to that of all other drug classes .
Because outcome data at this dose are lacking , HCTZ is an inappropriate first-line drug for the treatment of hypertension
OBJECTIVES The purpose of this study was to evaluate the antihypertensive efficacy of hydrochlorothiazide ( HCTZ ) by ambulatory blood pressure ( BP ) monitoring .
BACKGROUND HCTZ is the most commonly prescribed antihypertensive drug worldwide .
More than 97 % of all HCTZ prescriptions are for 12.5 to 25 mg per day .
The antihypertensive efficacy of HCTZ by ambulatory BP monitoring is less well defined .
Effects of losartan on hypertension and left ventricular mass: a long-term study
This study evaluated the anti-hypertensive efficacy , tolerability and effects on left ventricular mass of losartan , a selective angiotensin II receptor antagonist , after 22 months in patients with essential hypertension . The study included 77 hypertensive patients who were r and omised at baseline to 22 months double-blind once-daily treatment with losartan 50 mg ( L group n = 44 patients , mean age 54 ± 9 years ) or hydrochlorothiazide 25 mg ( HCTZ group , n = 33 patients , mean age 56 ± 7 years ) . Routine haematology , blood chemistry , st and ard electrocardiography , echocardiography and ambulatory non-invasive 24-h blood pressure ( BP ) monitoring were performed at baseline and after 10 and 22 months . The results showed good tolerability and a significant mean systolic and diastolic BP reduction in all groups ( L group : 22 mm Hg and 11 mm Hg ; HCTZ group : 11 mm Hg and 7 mm Hg , respectively for systolic and diastolic mean BP ) . Moreover , a remarkable reduction in left ventricular mass index was reached after 10 and 22 months only in the L group ( L group : Δ = –11 g/m2 , P < 0.02 ; hctz group : δ = –5 g/m2 , P = 0.38 ) . In conclusion , losartan was well tolerated and produced a significant reduction in BP and left ventricular mass in hypertensive
The antihypertensive efficacy of HCTZ in its daily dose of 12.5 to 25 mg as measured in head-to-head studies by ambulatory BP measurement is consistently inferior to that of all other drug classes .
Because outcome data at this dose are lacking , HCTZ is an inappropriate first-line drug for the treatment of hypertension
OBJECTIVES The purpose of this study was to evaluate the antihypertensive efficacy of hydrochlorothiazide ( HCTZ ) by ambulatory blood pressure ( BP ) monitoring .
BACKGROUND HCTZ is the most commonly prescribed antihypertensive drug worldwide .
More than 97 % of all HCTZ prescriptions are for 12.5 to 25 mg per day .
The antihypertensive efficacy of HCTZ by ambulatory BP monitoring is less well defined .