Once-daily dihydropyridine calcium channel blockers appeared to lower blood pressure by a relatively constant amount throughout the 24-hour dosing interval .
Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours .
BACKGROUND Calcium channel blockers are a heterogeneous class of drugs , including dihydropyridine and non-dihydropyridine subgroups , commonly used in the treatment of hypertension .
A systematic review of the 24-hour time course of the blood pressure-lowering effect has not been published .
OBJECTIVES To assess how much variation there is in hourly systolic and diastolic blood pressure lowering by dihydropyridine calcium channel blockers over a 24-hour period in people with hypertension aged 18 years or over , with baseline systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg , or both .
Effectiveness of once-daily monotherapy with a new nifedipine sustained release calcium antagonist.
Data from 2 separate multicenter , double-blind clinical studies following the same protocol , except for the selection of doses , were pooled to evaluate the efficacy and tolerability of fixed doses of a new sustained-release ( SR ) formulation of nifedipine compared with placebo in 388 patients with mild to moderate uncomplicated essential hypertension . After a 3 - 6 week placebo washout period , the patients were r and omized to receive either placebo or nifedipine SR-20 mg ( study I only ) , 50 mg , 100 mg , or 150 mg ( study II only ) . Among the 278 patients who completed 6 weeks of active therapy , mean supine diastolic blood pressure reductions from pretreatment baseline were 5.9 , 9.3 , 9.2 , 11.1 , and 13.2 mm Hg in the placebo , 20- , 50- , 100- , and 150-mg groups , respectively . The reductions achieved in each of the nifedipine SR groups were statistically significant versus baseline values ( p less than 0.001 ) . All nifedipine-SR doses reduced supine systolic blood pressure significantly more than placebo ( p less than 0.001 ) . In addition , there was a significant linear relationship between the log of the dose and the blood pressure reduction ( p less than 0.05 ) . Automated ambulatory blood pressure recordings performed in 221 of the patients showed that the blood pressure was lowered evenly through the entire 24-hour dosing period . The doses that were effective and associated with the fewest adverse reactions were 20 mg and 50 mg once daily
Once-daily dihydropyridine calcium channel blockers appeared to lower blood pressure by a relatively constant amount throughout the 24-hour dosing interval .
Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours .
BACKGROUND Calcium channel blockers are a heterogeneous class of drugs , including dihydropyridine and non-dihydropyridine subgroups , commonly used in the treatment of hypertension .
A systematic review of the 24-hour time course of the blood pressure-lowering effect has not been published .
OBJECTIVES To assess how much variation there is in hourly systolic and diastolic blood pressure lowering by dihydropyridine calcium channel blockers over a 24-hour period in people with hypertension aged 18 years or over , with baseline systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg , or both .