We found no evidence to support a protective association between perinatal use of probiotics and doctor diagnosed asthma or childhood wheeze .
R and omised controlled trials to date have not yielded sufficient evidence to recommend probiotics for the primary prevention of these disorders .
OBJECTIVE To evaluate the association of probiotic supplementation during pregnancy or infancy with  childhood asthma and wheeze .
Human Milk Probiotic Lactobacillus fermentum CECT5716 Reduces the Incidence of Gastrointestinal and Upper Respiratory Tract Infections in Infants
Objectives : The aim of the study was to examine the effects of a follow-on formula containing Lactobacillus fermentum CECT5716 ( L fermentum ) on the incidence of infections in infants between the ages of 6 and 12 months . Patients and Methods : A r and omized double-blinded controlled study including infants at the age of 6 months was conducted . Infants were assigned r and omly to either follow-on formula supplemented with L fermentum plus galactooligosaccharide ( experimental group , EG ) , or the same formula supplemented with only galactooligosaccharide ( control group , CG ) . The main outcome was the incidence of infections for the 6-month duration of the study . Results : The EG showed a significant 46 % reduction in the incidence rate ( IR ) of gastrointestinal infections ( EG : 0.196 ± 0.51 , CG : 0.363 ± 0.53 , IR ratio 0.54 , 95 % confidence interval [ CI ] 0.307–0.950 , P = 0.032 ) , 27 % reduction in the incidence of upper respiratory tract infections ( EG : 0.969 ± 0.96 , CG : 1.330 ± 1.23 , IR ratio 0.729 , 95 % CI 0.46–1.38 , P = 0.026 ) , and 30 % reduction in the total number of infections ( EG : 1.464 ± 1.15 , CG : 2.077 ± 1.59 , IR ratio 0.70 , 95 % CI 0.46–1.38 , P = 0.003 ) , at the end of the study period compared with CG . Conclusions : Administration of a follow-on formula with L fermentum CECT5716 may be useful for the prevention of community-acquired gastrointestinal and upper respiratory infections
We found no evidence to support a protective association between perinatal use of probiotics and doctor diagnosed asthma or childhood wheeze .
R and omised controlled trials to date have not yielded sufficient evidence to recommend probiotics for the primary prevention of these disorders .
OBJECTIVE To evaluate the association of probiotic supplementation during pregnancy or infancy with  childhood asthma and wheeze .