The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .
Early outcome after open versus extraperitoneal endoscopic tension-free hernioplasty: a randomized clinical trial.
BACKGROUND The use of minimal access surgery for repair of groin hernias is controversial . The aim of this study was to compare endoscopic tension-free hernia repair with open tension-free hernia repair within a r and omized clinical trial . METHODS One hundred twenty patients were r and omized by four surgeons during a 1-year period . Early outcome measures were then analyzed by intention to treat . RESULTS Median postoperative pain scores ( 63 [ interquartile range ( IQR ) , 23 to 81 ] versus 35 [ IQR , 17 to 62 ] ; p = 0.004 ) and analgesia requirements ( 2.5 [ IQR , 2 to 4 ] doses verus 2.0 [ IQR , 1 to 3 ] doses ; p = 0.0008 ) were significantly less for patients undergoing endoscopic hernia repair .  Hospital stay ( 1 [ IQR , 0 to 1 ] day versus 2 [ IQR , 1 to 2 ] days ; p < 0.0001 ) was also significantly reduced for the endoscopic group . Wound complications occurred significantly more frequently in the open group . No difference in pulmonary function or metabolic response to trauma ( interleukin-6 , C-reactive protein , glucose , albumin ) was observed between the groups . CONCLUSIONS This study shows significant short-term advantages for endoscopic tension-free repair over open tension-free repair . However , larger studies with a longer follow-up period are required to establish the relative merits of both procedures in the management of patients with groin hernias
The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .