This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .
The FTO genotype as a useful predictor of body weight maintenance: initial data from a 5-year follow-up study.
OBJECTIVE We examined associations between the fat-mass and obesity-associated ( FTO ) gene ( rs9939609 ) and any weight change over a 5-year period following a 14-week lifestyle intervention  among middle-aged Japanese women . MATERIAL S/ METHODS One hundred twenty-eight Japanese women ( BMI > 25 kg/m² ) participated in a 14-week weight loss intervention between 2004 and 2006 . Of the participants , 62 consented to the 5-year follow-up measurement session . Of these women , 47 women who achieved a weight loss of at least 10 % from their baseline values during the 14-week intervention were included in the analysis . Body weight , body fat , abdominal fat assessed by CT scans , and metabolic risk factors ( i.e. , blood pressure , lipids , and glucose ) were measured at baseline , post-intervention , and at the 5-year follow-up . RESULTS During the 5-year non-intervention period , increases in body weight , fat mass , total abdominal fat , and subcutaneous abdominal fat were significantly greater in subjects with the homozygous minor allele ( AA genotype , n=4 ; 8.5 % ) than in those with the homozygous major allele ( TT genotype , n=31 ; 66.0 % ) or heterozygous allele ( TA genotype , n=12 ; 25.5 % ) . In multiple regression analyses , the variation in rs9939609 was a significant and independent predictor ( P<0.001 ) for regaining weight during the 5-year follow-up . CONCLUSIONS Our data suggest that Japanese women with the risk allele ( AA ) of rs9939609 may have more difficulty preventing fat gain from reoccurring after weight loss intervention than women with the other genotypes
This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .