Vitamin K supplementation did not affect insulin sensitivity as measured by homeostasis model assessment of insulin resistance , fasting plasma glucose , fasting plasma insulin , C-reactive protein , adiponectin , leptin , and interleukin-6 levels .
Our analysis suggests no effect of vitamin K supplementation on insulin sensitivity
OBJECTIVE To perform a systematic review and meta- analysis of r and omized , placebo-controlled trials to assess the effect of vitamin K supplementation on insulin sensitivity .
Endocrine Actions of Osteocalcin
Osteocalcin is the most abundant noncollagenous protein of bone matrix . Once transcribed , this protein undergoes posttranslational modifications within osteoblastic cells before its secretion , including the carboxylation of three glutamic residues in glutamic acid , which is essential for hydroxyapatite binding and deposition in the extracellular matrix of bone . Recent provocative data from experimental observations in mice showed that the circulating undercarboxylated fraction of osteocalcin increases insulin secretion and sensitivity , lowers blood glucose , and decreases visceral fat in both genders , while it enhances testosterone production by the testes in males . Moreover , both total and undercarboxylated osteocalcins increase following physical activity with potential positive effects on glucose tolerance . Despite that these evidence s have been only in part confirmed in humans , further prospect i ve investigations are needed to definitively establish the endocrine role of osteocalcin both in the general population and cohorts of patients with diabetes or other metabolic disorders
Vitamin K supplementation did not affect insulin sensitivity as measured by homeostasis model assessment of insulin resistance , fasting plasma glucose , fasting plasma insulin , C-reactive protein , adiponectin , leptin , and interleukin-6 levels .
Our analysis suggests no effect of vitamin K supplementation on insulin sensitivity
OBJECTIVE To perform a systematic review and meta- analysis of r and omized , placebo-controlled trials to assess the effect of vitamin K supplementation on insulin sensitivity .