Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial.
Background : There are conflicting views in the literature as to whether vitamin D2 and vitamin D3 are equally effective in increasing and maintaining serum concentrations of 25-hydroxyvitamin D [ 25(OH)D ] , particularly at lower doses of vitamin D. Objective : We aim ed to investigate whether vitamin D2 or vitamin D3 fortified in juice or food , at a relatively low dose of 15 μg/d , was effective in increasing serum total 25(OH)D and to compare their respective efficacy in South Asian and white European women over the winter months within the setting of a large r and omized controlled trial . Design : A r and omized , double-blind , placebo-controlled food-fortification trial was conducted in healthy South Asian and white European women aged 20 - 64 y ( n = 335 ; Surrey , United Kingdom ) who consumed placebo , juice supplemented with 15 μg vitamin D2 , biscuit supplemented with 15 μg vitamin D2 , juice supplemented with 15 μg vitamin D3 , or biscuit supplemented with 15 μg vitamin D3 daily for 12 wk  . Serum 25(OH)D was measured by liquid chromatography-t and em mass spectrometry at baseline and at weeks 6 and 12 of the study . Results : Postintervention in the 2 ethnic groups combined , both the vitamin D3 biscuit and the vitamin D3 juice groups showed a significantly greater absolute incremental change ( Δ ) in total 25(OH)D when compared with the vitamin D2 biscuit group [ Δ ( 95 % CI ) : 15.3 nmol/L ( 7.4 , 23.3 nmol/L ) ( P < 0.0003 ) and 16.0 nmol/L ( 8.0 , 23.9 nmol/L ) ( P < 0.0001 ) ] , the vitamin D2 juice group [ Δ ( 95 % CI ) : 16.3 nmol/L ( 8.4 , 24.2 nmol/L ) ( P < 0.0001 ) and 16.9 nmol/L ( 9.0 , 24.8 nmol/L ) ( P < 0.0001 ) ] , and the placebo group [ Δ ( 95 % CI ) : 42.3 nmol/L ( 34.4 , 50.2 nmol/L ) ( P < 0.0001 ) and 42.9 nmol/L ( 35.0 , 50.8 nmol/L ) ( P < 0.0002 ) ] . Conclusions : With the use of a daily dose of vitamin D relevant to public health recommendations ( 15 μg ) and in vehicles relevant to food-fortification strategies , vitamin D3 was more effective than vitamin D2 in increasing serum 25(OH)D in the wintertime . Vitamin D3 may therefore be a preferential form to optimize vitamin D status within the general population . This trial was registered at www.controlled-trials.com as IS RCT N23421591
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .