A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .
A Randomized, Double-Blind, Crossover Trial of Modafinil on Mood
Modafinil , a medication for the excessive sleepiness associated with narcolepsy , has been hypothesized to improve not just alertness but mood as well . The purpose of this study was to determine how treatment with modafinil affects mood in healthy volunteers . Normal healthy volunteers ( n = 12 , 10 men and 2 women ; 30 - 44 years ) underwent a 3-day , counterbalanced , r and omized , crossover , inpatient trial of modafinil ( 400 mg daily ) versus placebo with 4-day washout period between 2 treatments . Mood was assessed daily using both the Positive and Negative Affect Schedule and a general mood scale , which consisted of 10 bipolar adjective ratings based on a severity scale ranging from 1 to 10 . Modafinil increased general mood and Negative Affect scales relative to placebo and had a significant effect on Positive Affect scales . These results suggest that modafinil may have general mood-elevating effects accompanied by increased negative affect ( anxiety ) . The findings may have implication s for clinical practice , in particular for the adjunctive use of modafinil in treatment-resistant depression
A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .