Based on the existing information , it is not possible to establish the role of antioxidants and vitamin D supplementation in atopic disease development .
There is no evidence of major effects of prenatal use of folic acid on asthma or allergies .
The association of some nutritional interventions with less atopic sensitization seems rather speculative even if such an effect has not been found for some other foods .
The findings indicate rather a balanced and diverse diet without restrictions than a special dietary protocol .
Farming-related exposures may protect against the development of atopic disorders in children .
Long-chain polyunsaturated fatty acids and probiotics seem to be promising c and i date s for allergy prevention .
The paper refers to the recently published empirical data and systematic review s on the impact of diets , foods , nutrients and bioactive substance exposures in pregnancy and in early infancy , on the development of atopic disorders .
Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood.
BACKGROUND The impact of breast milk feeding on susceptibility to asthma in childhood is highly controversial , due in part to failure of the majority of studies in the area to adequately account for key confounders exemplified by respiratory infection history , plus the effects of recall bias . METHODS As part of a prospect i ve cohort study on the role of respiratory infections in asthma development in high-risk children , we measured the concentration of a panel of anti-infective proteins in maternal milk sample s  and analyzed associations between these and subsequent atopy- , infection- , and asthma-related outcomes prospect ively to age 10 years . RESULTS We observed significant but transient inverse associations between the concentration of milk proteins and susceptibility to upper respiratory infections in year 1 only , and parallel but positive transient associations with early lower respiratory infections and atopy . No associations were seen with asthma-related outcomes . CONCLUSIONS Breast milk feeding may influence the expression of inflammatory symptoms associated with respiratory infections and atopy in early life , but these effects appear to be inconsistent and transient . The heterogeneous nature of breast-feeding effects suggests it may influence systemic immunoinflammatory function at several different levels
Based on the existing information , it is not possible to establish the role of antioxidants and vitamin D supplementation in atopic disease development .
There is no evidence of major effects of prenatal use of folic acid on asthma or allergies .
The association of some nutritional interventions with less atopic sensitization seems rather speculative even if such an effect has not been found for some other foods .
The findings indicate rather a balanced and diverse diet without restrictions than a special dietary protocol .
Farming-related exposures may protect against the development of atopic disorders in children .
Long-chain polyunsaturated fatty acids and probiotics seem to be promising c and i date s for allergy prevention .
The paper refers to the recently published empirical data and systematic review s on the impact of diets , foods , nutrients and bioactive substance exposures in pregnancy and in early infancy , on the development of atopic disorders .