The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Efficacy, tolerance and hormonal effects of a new oral angiotensin converting enzyme inhibitor, ramipril (HOE 498), in mild to moderate primary hypertension.
The immediate ( 0 to 24 hours ) and long-term ( 4 weeks ) hypotensive effects of a new long-acting angiotensin converting enzyme inhibitor , ramipril ( HOE 498 ) , as well as adverse effects and tolerance , were evaluated in 34 patients with primary hypertension . Further , effects on serum and urinary aldosterone and circulating angiotensin II concentrations were measured . After short- and long-term administration of 5 or 10 mg of ramipril , the mean blood pressure was significantly lowered compared with placebo . The mean maximum decrease in blood pressure was noted 4 to 8 hours after administration of ramipril once daily . Sustained blood pressure reduction was achieved after 4 weeks of treatment . Serum concentrations of aldosterone and plasma levels of circulating angiotensin II were reduced for up to 12 hours after drug intake , and tended to return to pretreatment levels at 24 hours . Serum angiotensin converting enzyme activity was markedly suppressed for more than 24 hours after a single dose of 5 or 10 mg ramipril . No subjective or objective adverse effects were noted , and the tolerance to the drug was very good
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .