Meta-regression showed that gastric pouch volume , alimentary limb length and biliopancreatic limb length were not associated with changes in ghrelin levels .
Conclusion Fasting total ghrelin levels decreased in the short term ( ≤ 3 months ) and increased in the long term ( > 3 months ) after RYGB
Background Roux-en-Y gastric bypass ( RYGB ) is considered effective for weight loss and for treatment of many obesity-related metabolic diseases .
Ghrelin is an essential orexigenic peptide that plays an indispensable role in controlling body weight and energy homeostasis of post-operative patients .
This systematic review and meta- analysis aim ed to investigate changes in the level of fasting total ghrelin following RYGB .
Ghrelin, leptin, and glycemic control after sleeve gastrectomy versus Roux-en-Y gastric bypass-results of a randomized clinical trial.
BACKGROUND Sleeve gastrectomy ( SG ) and Roux-en-Y gastric bypass ( RYGB ) cause weight loss and metabolic improvement , but results of published studies are contradictory . OBJECTIVES The aim of this study was to compare the effects of SG and RYGB on ghrelin , leptin , and glucose homeostasis in a r and omized controlled trial . SETTING University hospital , Pol and . METHODS Seventy-two morbidly obese patients were r and omly selected to undergo either SG ( n = 36 ) or RYGB ( n = 36 ) .  Fasting ghrelin , leptin , glucose , insulin , C-peptide , glucagon , glycated hemoglobin , and homeostasis model assessment of insulin resistance were assessed preoperatively and at 1 , 6 , and 12 months postoperatively . No differences were found in anthropometric and biochemical parameters between the study groups at baseline . RESULTS Sixty-nine ( 95.8 % ) patients completed the study .  Percentage of excess weight loss at 12 months was 67.6±19.3 % after SG and 64.2±18.5 % after RYGB ( P>.05 ) . Fasting ghrelin levels decreased 1 month after SG ( from 76.8 pmol/L to 35.3 pmol/L ; P<.05 ) and remained reduced until 12 months ( 41.6 pmol/L ; P<.05 ) but increased 12 months after RYGB from 74.6 pmol/L to 130.2 pmol/L ( P<.05 ) . Leptin , glucose , insulin , and C-peptide concentrations and glycated hemoglobin and homeostasis model assessment of insulin resistance values decreased significantly in both groups during 12 months . CONCLUSIONS RYGB and SG induce comparable weight loss and improvement in metabolism of glucose . Ghrelin levels decrease after SG and increase after RYGB , but this difference does not affect similar outcomes of these procedures during 1-year follow-up . The contribution of ghrelin to weight loss or metabolic benefits after bariatric surgery is not straightforward , but rather influenced by multiple factors
Meta-regression showed that gastric pouch volume , alimentary limb length and biliopancreatic limb length were not associated with changes in ghrelin levels .
Conclusion Fasting total ghrelin levels decreased in the short term ( ≤ 3 months ) and increased in the long term ( > 3 months ) after RYGB
Background Roux-en-Y gastric bypass ( RYGB ) is considered effective for weight loss and for treatment of many obesity-related metabolic diseases .
Ghrelin is an essential orexigenic peptide that plays an indispensable role in controlling body weight and energy homeostasis of post-operative patients .
This systematic review and meta- analysis aim ed to investigate changes in the level of fasting total ghrelin following RYGB .