This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .
Small-Dose Dexamethasone Reduces Nausea and Vomiting After Laparoscopic Cholecystectomy: A Comparison of Tropisetron with Saline
Dexamethasone is an effective antiemetic drug , but the efficacy of small-dose dexamethasone 5 mg on the prophylaxis of postoperative nausea and vomiting ( PONV ) in patients undergoing laparoscopic chole-cystectomy has not been evaluated . We , therefore , evaluated the prophylactic effect of small-dose dexamethasone ( 5 mg ) on PONV in patients undergoing laparoscopic cholecystectomy .  Tropisetron and saline served as controls . One-hundred-twenty patients scheduled for laparoscopic cholecystectomy were enrolled in a r and omized , double-blinded , placebo-controlled study . At the induction of anesthesia , the Dexamethasone group received IV dexamethasone 5 mg , the Tropisetron group received IV tropisetron 2 mg , and the Pla- cebo group received IV saline . We found that both dexamethasone and tropisetron significantly decreased the following variables : the total incidence of PONV ( P < 0.01 ) , more than four vomiting episodes ( P < 0.05 ) , and the proportions of patients requiring rescue antiemetics ( P < 0.05 ) . The differences between the Dexamethasone and Tropisetron groups were not significant . We conclude that prophylactic IV dexamethasone 5 mg significantly reduces the incidence of PONV in patients undergoing laparoscopic cholecystectomy . At this dose , dexamethasone is as effective as tropisetron 2 mg and is more effective than placebo
This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .