Overall , the current meta- analysis demonstrated that ALA administration may lead to an improvement in glucose homeostasis parameters and lipid profiles except HDL-cholesterol levels
OBJECTIVE This systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was performed to summarize the effect of alpha-lipoic acid ( ALA ) supplementation on glycemic control and lipid profiles among patients with metabolic diseases .
A Preliminary Investigation of &agr;-Lipoic Acid Treatment of Antipsychotic Drug-Induced Weight Gain in Patients With Schizophrenia
Weight gain and other metabolic disturbances have now become discouraging , major side effects of atypical antipsychotic drugs ( AAPDs ) . The novel strategies required to counteract these serious consequences , however , should avoid modulating the activities of the neurotransmitter receptors involved because those receptors are the therapeutic targets of AAPDs . Adenosine monophosphate-activated protein kinase is an enzyme that plays a pivotal role in energy homeostasis . We hypothesized that & agr;-lipoic acid ( ALA ) , which is known to modulate adenosine monophosphate-activated protein kinase activity in the hypothalamus and peripheral tissues , would ameliorate AAPD-induced  weight gain . We describe the case series of a 12-week ALA trial in schizophrenia patients treated with AAPDs . Two of 7 enrolled subjects were dropped from the study because of noncompliance and dem and for new medication to treat depressive symptoms , respectively . The mean ( SD ) weight loss was 3.16 ( 3.20 ) kg ( P = 0.043 , last observation carried forward ; median , 3.03 kg ; range , 0 - 8.85 kg ) . On average , body mass index showed a significant reduction ( P = 0.028 ) over the 12 weeks . During the same period , a statistically significant reduction was also observed in total cholesterol levels ( P = 0.042 ) , and there was a weak trend toward the reduction in insulin resistance ( homeostasis model assessment of insulin resistance ) ( P = 0.080 ) . Three subjects reported increased energy subjectively . The total scores on the Brief Psychiatric Rating Scale and the Montgomery-Asberg Depression Rating Scale did not vary significantly during the study . These preliminary data suggest the possibility that ALA can ameliorate the adverse metabolic effects induced by AAPDs . To confirm the benefits of ALA , more extended study is warranted
Overall , the current meta- analysis demonstrated that ALA administration may lead to an improvement in glucose homeostasis parameters and lipid profiles except HDL-cholesterol levels
OBJECTIVE This systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was performed to summarize the effect of alpha-lipoic acid ( ALA ) supplementation on glycemic control and lipid profiles among patients with metabolic diseases .