Conclusion Our findings may encourage curcumin supplementation based on its meaningful effect on glycemic control and positive trend on lipid outcomes in prediabetes and T2DM
Scope Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus ( T2DM ) .
This study aim ed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM .
Efficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic Patients
Abstract It is known that there is a significant interplay of insulin resistance , oxidative stress , dyslipidemia , and inflammation in type 2 diabetes mellitus ( T2DM ) . The study was undertaken to investigate the effect of turmeric as an adjuvant to anti-diabetic therapy . Sixty diabetic subjects on metformin therapy  were recruited and r and omized into two groups ( 30 each ) . Group I received st and ard metformin treatment while group II was on st and ard metformin therapy with turmeric ( 2 g ) supplements for 4 weeks . The biochemical parameters were assessed at the time of recruitment for study and after 4 weeks of treatment . Turmeric supplementation in metformin treated type 2 diabetic patient significantly decreased fasting glucose ( 95 ± 11.4 mg/dl , P < 0.001 ) and HbA1c levels ( 7.4 ± 0.9 % , P < 0.05 ) . Turmeric administered group showed reduction in lipid peroxidation , MDA ( 0.51 ± 0.11 µmol/l , P < 0.05 ) and enhanced total antioxidant status ( 511 ± 70 µmol/l , P < 0.05 ) . Turmeric also exhibited beneficial effects on dyslipidemia LDL cholesterol ( 113.2 ± 15.3 mg/dl , P < 0.01 ) , non HDL cholesterol ( 138.3 ± 12.1 mg/dl , P < 0.05 ) and LDL/HDL ratio ( 3.01 ± 0.61 , P < 0.01 ) and reduced inflammatory marker , hsCRP ( 3.4 ± 2.0 mg/dl , P < 0.05 ) . Turmeric supplementation as an adjuvant to T2DM on metformin treatment had a beneficial effect on blood glucose , oxidative stress and inflammation
Conclusion Our findings may encourage curcumin supplementation based on its meaningful effect on glycemic control and positive trend on lipid outcomes in prediabetes and T2DM
Scope Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus ( T2DM ) .
This study aim ed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM .