Conclusions and Relevance This systematic review and meta- analysis did not show a significant beneficial or detrimental association of HT with muscle mass .
Importance Hormone therapy ( HT ) has been suggested for protection against age-related muscle weakness in women .
However , the potential for HT-associated health risks necessitates a better underst and ing of the direction and magnitude of the association between HT and health outcomes , such as lean body mass ( LBM ) .
Objective To determine whether HT was associated with reduced LBM loss compared with not receiving HT  among postmenopausal women aged 50 years and older .
The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials
Flaws in the design , conduct , analysis , and reporting of r and omised trials can cause the effect of an intervention to be underestimated or overestimated . The Cochrane Collaboration ’s tool for assessing risk of bias aims to make the process clearer and more
Conclusions and Relevance This systematic review and meta- analysis did not show a significant beneficial or detrimental association of HT with muscle mass .
Importance Hormone therapy ( HT ) has been suggested for protection against age-related muscle weakness in women .
However , the potential for HT-associated health risks necessitates a better underst and ing of the direction and magnitude of the association between HT and health outcomes , such as lean body mass ( LBM ) .
Objective To determine whether HT was associated with reduced LBM loss compared with not receiving HT  among postmenopausal women aged 50 years and older .