Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Simvastatin Combined With Ramipril Treatment in Hypercholesterolemic Patients
Mechanisms underlying biological effects of statin and angiotensin-converting enzyme inhibitor therapies differ . Thus , we studied vascular responses to combination therapy in hypercholesterolemic patients . A r and omized , double-blind , placebo-controlled , crossover trial was conducted with 50 hypercholesterolemic patients with simvastatin and either placebo or ramipril ( study I ) and in 45 hypercholesterolemic diabetic patients with simvastatin or ramipril with placebo or simvastatin combined with ramipril ( study II ) for 2 months with 2 months washout . In study I simvastatin combined with ramipril significantly reduced blood pressure after 2 months . Simvastatin alone or combined with ramipril significantly changed lipoproteins , improved percent flow-mediated dilator response to hyperemia by 30±5 % and 53±6 % , respectively ( P < 0.001 ) , and reduced plasma levels of malondialdehyde by 4±7 % ( P = 0.026 ) and 25±4 % ( P < 0.001 ) , respectively . Monocyte chemoattractant protein-1 levels decreased by 3±3 % and 12±2 % , respectively ( P = 0.049 and P < 0.001 , respectively ) , C-reactive protein levels changed by 0 % and 18 % , respectively ( P = 0.036 and P < 0.001 , respectively ) , and plasminogen activator inhibitor-1 antigen levels changed by −7±7 % and 17±5 % , respectively ( P = 0.828 and P < 0.001 , respectively ) . In study II ramipril alone did not significantly change lipoproteins and C-reactive protein levels , however , simvastatin combined with ramipril significantly changed lipoproteins and C-reactive protein levels more than ramipril alone ( P < 0.001 and P = 0.048 by ANOVA , respectively ) . Ramipril alone or simvastatin combined with ramipril significantly improved the percent flow-mediated dilator response to hyperemia ( both P < 0.001 ) , however , simvastatin combined with ramipril showed significantly more improvement than ramipril alone ( P < 0.001 by ANOVA ) . Simvastatin combined with ramipril  significantly improved endothelium-dependent vasodilation and fibrinolysis potential and reduced plasma levels of oxidant stress and inflammation markers in hypercholesterolemic patients
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .