The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Evaluation of the antihypertensive effect of once-a-day trandolapril by 24-hour ambulatory blood pressure monitoring. The Italian Trandolapril Study Group.
The aim of this study was to evaluate the effects of tr and olapril on 24-hour blood pressure in patients with mild-to-moderate essential hypertension . After a washout period of 4 weeks , 42 patients were r and omized to receive 2 mg of tr and olapril once daily and 20 to receive placebo in a double-blind fashion for 6 weeks . This was followed by a second washout period of 4 weeks . At the end of each period , clinic blood pressure was assessed at 24 hours after the last dose and 24-hour ambulatory blood pressure was measured noninvasively , taking blood pressure readings every 15 minutes during the day and every 20 minutes during the night . Two patients were dropped out before any blood pressure evaluation under treatment . Analysis of ambulatory blood pressure was performed in 48 patients who met the criteria for the minimal number of ambulatory blood pressure data ( 2 values per hour during the day and 1 value per hour in the night ) . In the tr and olapril-treated group ( n = 41 )  clinic systolic/diastolic blood pressures were 159.8 + /- 2.0/102.4 + /- 0.8 , 146.8 + /- 2.3/94.8 + /- 1.1 , and 155.7 + /- 2.0/99.2 + /- 0.7 mm Hg in the pretreatment , treatment , and post-treatment periods , respectively . The corresponding values for 24-hour mean blood pressure ( n = 31 ) were 139.5 + /- 1.9/91.2 + /- 1.5 , 131.0 + /- 2.0/84.3 + /- 1.2 , and 139.7 + /- 1.8/90.9 + /- 1.1 mmHg . The differences between the lower treatment , versus the higher pre- and post-treatment , values were all statistically significant ( p < 0.01 ) . ( ABSTRACT TRUNCATED AT 250 WORDS
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .