In conclusion , this review supports the hypothesis that hypovitaminosis D is associated with adverse outcomes after diverse surgical procedures .
The importance of vitamin D for musculoskeletal health has long been recognized , and awareness of significant extra-skeletal effects in health and disease is rapidly emerging .
Although it has been possible for many decades to quantify serum markers of vitamin D deficiency , and to correct deficiency at low cost and with high safety , the influence of vitamin D status on post-surgical outcomes has only recently been identified as a research topic of interest .
To the present , these data have not been the subject matter of formal review .
Accordingly , we conducted a systematic review to assess the association between perioperative vitamin D status and outcomes after surgery .
Reproducibility of serum 25-hydroxyvitamin d and vitamin D-binding protein levels over time in a prospective cohort study of black and white adults.
Prospect i ve epidemiologic studies generally rely on 1 baseline biologic sample from participants for measurement of prediagnostic biomarkers , assuming that 1 measurement adequately represents the participant 's " typical " level . The body of work assessing the reproducibility of circulating serum 25-hydroxyvitamin D ( 25(OH)D ) levels over time focuses almost exclusively on population s of European descent , and data for vitamin D-binding protein ( VDBP ) are virtually nonexistent . Thus , the authors measured levels of serum 25(OH)D and VDBP twice in sample s collected between 2005 and 2008 from 225 participants ( 155 black , 70 white ) in the Southern Community Cohort Study .  Reproducibility for 25(OH)D was uniformly high , with adjusted intraclass correlation coefficients ( ICCs ) of 0.84 ( 95 % confidence interval ( CI ) : 0.79 , 0.88 ) for blacks and 0.92 ( 95 % CI : 0.87 , 0.95 ) for whites , and there was substantial agreement for assignment of 25(OH)D quartile ( κ = 0.83 , 95 % CI : 0.78 , 0.87 ) and vitamin D adequacy status ( κ = 0.76 , 95 % CI : 0.69 , 0.83 ) . VDBP levels were highly stable over time , with adjusted ICCs of 0.97 ( 95 % CI : 0.96 , 0.98 ) for blacks and 0.96 ( 95 % CI : 0.93 , 0.97 ) for whites . These findings suggest that single , baseline 25(OH)D and VDBP serum measurements provide reasonably representative measures of these compounds for both white and black adults , demonstrating their utility as epidemiologic biomarkers in prospect i ve studies
In conclusion , this review supports the hypothesis that hypovitaminosis D is associated with adverse outcomes after diverse surgical procedures .
The importance of vitamin D for musculoskeletal health has long been recognized , and awareness of significant extra-skeletal effects in health and disease is rapidly emerging .
Although it has been possible for many decades to quantify serum markers of vitamin D deficiency , and to correct deficiency at low cost and with high safety , the influence of vitamin D status on post-surgical outcomes has only recently been identified as a research topic of interest .
To the present , these data have not been the subject matter of formal review .
Accordingly , we conducted a systematic review to assess the association between perioperative vitamin D status and outcomes after surgery .