Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effect of two different doses of oral cholecalciferol supplementation on serum 25-hydroxy-vitamin D levels in healthy Indian postmenopausal women: A randomized controlled trial
Aim : To compare the effect of two different doses ( 500 and 1000 IU/day ) of oral vitamin D3 ( cholecalciferol ) on serum 25-hydroxy vitamin D [ 25(OH)D ] levels in apparently healthy postmenopausal Indian women . Material s and Methods : Serum 25(OH)D , calcium with albumin , phosphorus , and alkaline phosphatase were measured in 92 apparently healthy postmenopausal women . The subjects were r and omly assigned to one of the three groups and received supplementation for 3 months each . Each group received 1000 mg calcium carbonate daily while groups B and C received 500 and 1000 IU of cholecalciferol in addition , respectively . The tests were repeated after 3 months . Results : At baseline , 83.7 % subjects had vitamin D deficiency ( ≤20 ng/mL ) . The difference in the percentage change in mean serum 25(OH)D levels from baseline in group A ( –30.5 ± 5.3 % ) , group B ( + 8.9 ± 19.7 % ) , and in group C ( + 97.8 ± 53.3 % ) was statistically significant ( P < 0.001 ) between the three groups . Serum 25(OH)D level > 20 ng/mL was achieved in 4.7 % ( 1/21 ) , 16 % ( 4/25 ) , and 66.67 % ( 12/18 ) subjects in groups A , B , and C , respectively . No significant change was found in serum calcium , phosphorus , and alkaline phosphatase levels at 3 months in either of the groups from baseline . Conclusions : St and ard dose of cholecalciferol available in “ calcium tablets ” ( 250 IU per 500 mg calcium carbonate ) is not adequate for achieving optimum serum 25(OH)D levels in Indian postmenopausal women . Higher dose of vitamin D supplementation with 1000 IU/day ( 500 IU per 500 mg calcium carbonate ) daily is superior to the st and ard dose therapy . For achievement of optimum serum 25(OH)D levels ( > 30 ng/mL ) in Indian postmenopausal women , still higher doses of vitamin D are likely to be required
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .