Antihypertensive drugs reduce headache but it is unclear whether there are differences between drug classes .
Calcium channel blockers ( CCBs ) decrease variability in systolic blood pressure ( SBPV ) and stroke risk more than other classes , possibly due to decreased vascular tone .
If so , there might be a correlation between drug-class effects on variability in SBP and on headache .
Antihypertensive drugs reduce headache but the effect differs between classes , corresponding to their effects on SBPV and the risk of stroke .
This may partly be explained by consistent antihypertensive class effects on vascular tone in the peripheral ( variability ) and cerebrovascular circulations ( headache )
Amlodipine compared to nitrendipine in hypertensive patients: the effects on toleration in relationship to the onset of action.
Amlodipine and nitrendipine are calcium antagonists of the 1,4-dihydropyridine group which differ in their pharmacokinetic and pharmacodynamic properties . The clinical relevance of these differences was investigated in a study design ed to compare the efficacy and safety of once-daily amlodipine ( 5 mg ) and nitrendipine ( 20 mg ) in patients with mild-to-moderate essential hypertension . Ambulatory blood pressure monitoring and conventional measurements showed that amlodipine and nitrendipine produced comparable reductions in blood pressure after 4 weeks of treatment . However , the onset of the antihypertensive effect was gradual for amlodipine , while most of the reduction achieved at the end of treatment with nitrendipine was seen after the first dose . There were no significant changes in heart rate with amlodipine , but significant increases occurred during the first 6 h of nitrendipine treatment . Amlodipine was associated with a significantly lower incidence of vasodilator-related adverse effects at initiation of therapy ( headache , flushing , tachycardia ) compared with nitrendipine , which may reflect its slower onset of action . The different pharmacodynamic and toleration profiles of amlodipine and nitrendipine at therapeutically equivalent doses suggest that amlodipine may have advantages in the treatment of hypertension , especially in terms of the low incidence of acute side effects , which may ultimately translate into improved patient compliance
Antihypertensive drugs reduce headache but it is unclear whether there are differences between drug classes .
Calcium channel blockers ( CCBs ) decrease variability in systolic blood pressure ( SBPV ) and stroke risk more than other classes , possibly due to decreased vascular tone .
If so , there might be a correlation between drug-class effects on variability in SBP and on headache .
Antihypertensive drugs reduce headache but the effect differs between classes , corresponding to their effects on SBPV and the risk of stroke .
This may partly be explained by consistent antihypertensive class effects on vascular tone in the peripheral ( variability ) and cerebrovascular circulations ( headache )