This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
Impact of treatment with oral calcitriol on glucose indices in type 2 diabetes mellitus patients.
INTRODUCTION Type 2 diabetes is a major public health problem . Recent epidemiological evidence also points to a potential association of vitamin D insufficiency with adverse metabolic risks , including that for type 2 diabetes . SUBJECTS AND METHOD A double-blind r and omized placebo-controlled trial was carried out . Seventy subjects with type 2 diabetes , age 30 - 75 years old , were r and omly assigned in a double-blind fashion to two groups . One group received two capsules of calcitriol ( 0.25 μg 1,25-dihydroxy cholecalciferol per each capsule ) per day . The second group received placebo tablets . At the beginning , middle and the end of the 12 week supplementation trial , serum glucose , insulin , calcium and phosphorous , HbA1c and 25(OH ) vitamin D were measured . RESULTS There was no significant difference between two groups at baseline . At the end of the study , fasting plasma glucose increased in the control group ( p=0.038 ) , while it remained unchanged in calcitriol group . Level of insulin and HbA1c increased significantly in both groups ( p=0.013 and 0.0004 in treatment and control group ) . Regarding insulin resistance indices , there was a significant change in HOMA-IR and QUICKI in both groups ( p=0.023 and 0.002 in treatment and 0.001 and < 0.001 in control group respectively ) . Insulin secretion as assessed by HOMA-%β , remained relatively unchanged in the control group , while it increased significantly in the treatment group at the end of study ( p=0.009 ) . CONCLUSION Vitamin D supplementation attenuated the increase in glycemia , and increased insulin secretion , but had no effect on insulin resistance
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .