Atrial fibrillation history is statistically significantly associated with adverse major clinical outcomes in ICD-implanted HF patients .
Patients with AF have a higher risk of all-cause mortality , appropriate , and inappropriate ICD interventions compared with patients with no AF history .
AIMS To assess the association between atrial fibrillation ( AF ) and all-cause mortality and implantable cardioverter-defibrillators ( ICDs ) therapies  in heart failure ( HF ) patients with reduced ejection fraction and an ICD implanted .
Mortality and appropriate and inappropriate therapy in patients with ischaemic heart disease and implanted cardioverter-defibrillators for primary prevention: data from the Danish ICD Register.
AIMS To evaluate the incidences of and risk factors predisposing to appropriate and inappropriate shocks and mortality in a ' real-world ' population of patients with ischaemic heart disease ( IHD ) and implantable cardioverter defibrillators ( ICD ) for primary prevention of sudden cardiac death ( SCD ) . METHODS AND RESULTS In this nationwide cohort , we prospect ively followed 1609 patients with IHD and left ventricular dysfunction from the Danish ICD Register who received an ICD for primary prevention of SCD ( 1 January 2007 to 30 November 2011 ) . Primary study outcomes were appropriate shocks , inappropriate shocks , and all-cause mortality . Secondary study outcomes included the composite endpoints : appropriate therapy and inappropriate therapy ( defined as shock or anti-tachycardia pacing ) . All-cause mortality was 12.1 % during a mean follow-up time of 1.9 ± 1.3 years . Inappropriate shocks and therapy occurred in 2.6 % and 3.7 % during follow-up , respectively . Appropriate shocks and therapy was identified in 7.8 % and 13.4 % , respectively . Time-dependent multivariable Cox regression analyses were used to identify risk factors of inappropriate/appropriate shock , therapy and mortality . Implantation of a dual-chamber ICD was associated with increased risk of both inappropriate shocks and any inappropriate therapy compared to single-chamber ICD [ hazard ratios ( HR ) = 2.45 ; confidence intervals (CI):1.16 - 5.14 and HR = 2.38 ; CI:1.28 - 4.42 , respectively ] . No excess risk of mortality was associated with any device type . CONCLUSION In this nationwide study of IHD patients with an ICD for primary prevention of SCD , the incidence of appropriate shocks as well as inappropriate shocks were significantly lower than reported in r and omized trials . Implantation of a dual-chamber ICD was associated with more inappropriate shocks compared with single chamber devices
Atrial fibrillation history is statistically significantly associated with adverse major clinical outcomes in ICD-implanted HF patients .
Patients with AF have a higher risk of all-cause mortality , appropriate , and inappropriate ICD interventions compared with patients with no AF history .
AIMS To assess the association between atrial fibrillation ( AF ) and all-cause mortality and implantable cardioverter-defibrillators ( ICDs ) therapies  in heart failure ( HF ) patients with reduced ejection fraction and an ICD implanted .