Conclusions : CETP inhibitors are not associated with an increased risk of MACE or all-cause mortality .
There is a trend towards small reductions in nonfatal MI and cardiovascular death , though the clinical importance of such reductions is likely modest
Background : Cholesteryl ester transfer protein ( CETP ) inhibitors increase serum high-density lipoprotein cholesterol ( HDL-c ) concentration ; however , their impact on cardiovascular outcomes is not clear .
This systematic review examines the effect of CETP inhibitors on serum lipid profiles , cardiovascular events , and all-cause mortality .
Efficacy, safety, tolerability, and pharmacokinetic profile of evacetrapib administered as monotherapy or in combination with atorvastatin in Japanese patients with dyslipidemia.
The cholesteryl ester transfer protein ( CETP ) inhibitor evacetrapib has been previously shown to increase high-density lipoprotein cholesterol ( HDL-C ) and decrease low-density lipoprotein cholesterol ( LDL-C ) levels , as monotherapy or in combination with statins . In this study , 165 Japanese patients with elevated LDL-C or low HDL-C levels were r and omly assigned to receive placebo , evacetrapib monotherapy 30 mg , 100 mg , or 500 mg , atorvastatin 10 mg , or evacetrapib 100 mg in combination with atorvastatin 10 mg . After 12 weeks , evacetrapib monotherapy increased HDL-C levels by 74 % , 115 % , and 136 % and decreased LDL-C levels by 15 % , 23 % , and 22 % and CETP activity by 50 % , 83 % , and 95 % ( for the 30-mg , 100-mg , and 500-mg dose groups , respectively ) versus placebo . In combination with atorvastatin 10 mg , evacetrapib 100 mg increased HDL-C levels by 103 % and decreased LDL-C levels by 15 % and CETP activity by 68 % versus atorvastatin alone . After a 4- to 6-week washout , HDL-C , LDL-C , and CETP mass and activity returned to baseline levels in the evacetrapib-treated groups , and most patients had evacetrapib concentrations below the quantitation limit . Evacetrapib monotherapy or in combination with atorvastatin was not likely to be associated with any significant change in blood pressure and did not have any adverse effects on mineralocorticoid or glucocorticoid measures . Notably , plasma evacetrapib concentrations were mostly undetectable , and all pharmacodynamic biomarkers ( HDL-C and LDL-C levels and CETP mass and activity ) returned to baseline after a 4- to 6-week washout . In conclusion , evacetrapib as monotherapy or in combination with atorvastatin effectively decreased CETP activity and LDL-C levels and increased HDL-C levels after 12 weeks in Japanese patients with dyslipidemia
Conclusions : CETP inhibitors are not associated with an increased risk of MACE or all-cause mortality .
There is a trend towards small reductions in nonfatal MI and cardiovascular death , though the clinical importance of such reductions is likely modest
Background : Cholesteryl ester transfer protein ( CETP ) inhibitors increase serum high-density lipoprotein cholesterol ( HDL-c ) concentration ; however , their impact on cardiovascular outcomes is not clear .
This systematic review examines the effect of CETP inhibitors on serum lipid profiles , cardiovascular events , and all-cause mortality .