Probiotic supplementation showed beneficial effect in the prevention and treatment of radiation-induced diarrhea in experimental animal studies .
BACKGROUND AND AIMS Probiotic supplementation seems to provide beneficial effects in the prevention and treatment of  radiation-induced diarrhea .
We performed a systematic review and meta- analysis to estimate the efficacy of probiotic supplementation for prevention and treatment of  radiation-induced diarrhea .
Results of a double-blind, randomized study to evaluate the efficacy and safety of Antibiophilus® in patients with radiation-induced diarrhoea
Background and aims Gastrointestinal toxicity is frequently observed during radiotherapy for malignancies in the abdomen and pelvis . This study was performed to determine the efficacy and tolerability of Lactobacillus rhamnosus ( Antibiophilus ® ) in comparison to placebo in a double-blind trial design . Its aim was to determine any clinical ly relevant difference between Antibiophilus ® and placebo in terms of efficacy in patients suffering from mild to moderate diarrhoea induced by radiation therapy . Methods The study was performed in two radiotherapy units in Hungary ; the results are based on the data for 206 recruited patients . Results Based on statistical analysis , Antibiophilus ® patients showed superiority with respect to the number of bowel movements ( P < 0.10 ) and faeces consistency ratings by the investigators ( P < 0.05 ) at the study end . Statistical analysis of the patients ’ self-ratings with regard to diarrhoea grade and faeces consistency showed a statistically highly significant treatment-by-time interaction ( P < 0.001 ) which was supported by the evidence of tendencies or P values below the nominal 5 % level in the second half of this study . Conclusions Overall , there was a highly favourable benefit/risk ratio in favour of Antibiophilus ®
Probiotic supplementation showed beneficial effect in the prevention and treatment of radiation-induced diarrhea in experimental animal studies .
BACKGROUND AND AIMS Probiotic supplementation seems to provide beneficial effects in the prevention and treatment of  radiation-induced diarrhea .
We performed a systematic review and meta- analysis to estimate the efficacy of probiotic supplementation for prevention and treatment of  radiation-induced diarrhea .