Overall , the effect of physical interventions on physical performance was inconsistent .
Patient tailored interventions , i.e. continuously adapted to the capabilities of the patient were not found to be superior over interventions that were not .
Conclusions Evidence for the effect of physical interventions on physical performance in older patients during hospitalization was found uncertain .
Background To counteract decline in physical performance and physical activity in older patients during hospitalization , multiple physical interventions were developed .
However , it is unknown whether these are effective in this particular population .
This systematic review aim ed to identify the effect of physical interventions on physical performance and physical activity in older patients during hospitalization .
Resistance training prevents deterioration in quadriceps muscle function during acute exacerbations of chronic obstructive pulmonary disease.
RATIONALE Exacerbations of chronic obstructive pulmonary disease ( COPD ) acutely reduce skeletal muscle strength and result in long-term loss of functional capacity . OBJECTIVES To investigate whether resistance training is feasible and safe and can prevent deteriorating muscle function during exacerbations of COPD . METHODS Forty patients ( FEV(1 ) 49 + /- 17 % predicted ) hospitalized with a severe COPD exacerbation were r and omized to receive usual care or an additional resistance training program during the hospital admission . Patients were followed up for 1 month after discharge . Primary outcomes were quadriceps force and systemic inflammation . A muscle biopsy was taken in a subgroup of patients to assess anabolic and catabolic pathways . MEASUREMENTS AND MAIN RESULTS Resistance training did not yield higher systemic inflammation as indicated by C-reactive protein levels and could be completed uneventfully . Enhanced quadriceps force was seen at discharge ( + 9.7 + /- 16 % in the training group ; -1 + /- 13 % in control subjects ; P = 0.05 ) and at 1 month follow-up in the patients who trained . The 6-minute walking distance improved after discharge only in the group who received resistance training ( median 34 ; interquartile range , 14 - 61 m ; P = 0.002 ) . In a subgroup of patients a muscle biopsy showed a more anabolic status of skeletal muscle in patients who followed training . Myostatin was lower ( P = 0.03 ) and the myogenin/MyoD ratio tended to be higher ( P = 0.08 ) in the training group compared with control subjects . CONCLUSIONS Resistance training is safe , successfully counteracts skeletal muscle dysfunction during acute exacerbations of COPD , and may up-regulate the anabolic milieu in the skeletal muscle . Clinical trial registered with www . clinical trials.gov ( NCT00877084 )
Overall , the effect of physical interventions on physical performance was inconsistent .
Patient tailored interventions , i.e. continuously adapted to the capabilities of the patient were not found to be superior over interventions that were not .
Conclusions Evidence for the effect of physical interventions on physical performance in older patients during hospitalization was found uncertain .
Background To counteract decline in physical performance and physical activity in older patients during hospitalization , multiple physical interventions were developed .
However , it is unknown whether these are effective in this particular population .
This systematic review aim ed to identify the effect of physical interventions on physical performance and physical activity in older patients during hospitalization .