Azapirones may be less effective than benzodiazepines and we were unable to conclude if azapirones were superior to antidepressants , kava kava or psychotherapy .
Azapirones appeared to be well tolerated .
Azapirones appeared to be useful in the treatment of GAD , particularly for those participants who had not been on a benzodiazepine .
Azapirones may not be superior to benzodiazepines and do not appear as acceptable as benzodiazepines .
Side effects appeared mild and non serious in the azapirone treated group .
Longer term studies are needed to show that azapirones are effective in treating GAD , which is a chronic long-term illness
BACKGROUND Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from generalized anxiety disorder ( GAD ) .
However , several studies have shown conflicting results .
Whether azapirones are useful as first line treatment in general anxiety disorders still needs to be answered .
OBJECTIVES To assess the efficacy and the acceptability of azapirones for the treatment of GAD .
Double-blind comparison of buspirone and clorazepate in anxious outpatients.
Buspirone , a new nonbenzodiazepine anxiolytic agent , was compared with clorazepate in a double-blind , multicenter trial conducted with 336 out patients who had moderate to severe anxiety . The two treatments were equally effective for relief of symptoms , including anxiety with associated depression . Although both agents were generally well tolerated , the profile of side effects was dissimilar . Drowsiness and depression occurred significantly ( p less than 0.055 ) more frequently with clorazepate , whereas nausea and headache occurred significantly ( p less than 0.055 ) more frequently with buspirone . Clorazepate-treated patients were significantly ( p less than 0.055 ) more likely to have had an adverse experience that was considered drug related or that interfered with the therapeutic effect . In this study , buspirone was shown to be an effective antianxiety agent , causing significantly less sedation than clorazepate
Azapirones may be less effective than benzodiazepines and we were unable to conclude if azapirones were superior to antidepressants , kava kava or psychotherapy .
Azapirones appeared to be well tolerated .
Azapirones appeared to be useful in the treatment of GAD , particularly for those participants who had not been on a benzodiazepine .
Azapirones may not be superior to benzodiazepines and do not appear as acceptable as benzodiazepines .
Side effects appeared mild and non serious in the azapirone treated group .
Longer term studies are needed to show that azapirones are effective in treating GAD , which is a chronic long-term illness
BACKGROUND Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from generalized anxiety disorder ( GAD ) .
However , several studies have shown conflicting results .
Whether azapirones are useful as first line treatment in general anxiety disorders still needs to be answered .
OBJECTIVES To assess the efficacy and the acceptability of azapirones for the treatment of GAD .