The associations were largely consistent and significant among individuals from different socioeconomic background s and baseline characteristics .
Conclusions /interpretationAdoption of a healthy lifestyle is associated with substantial risk reduction in type 2 diabetes and long-term adverse outcomes among diabetic individuals .
Aims /hypothesisA healthy lifestyle has been widely recommended for the prevention and management of type 2 diabetes .
However , no systematic review has summarised the relationship between combined lifestyle factors ( including , but not limited to , smoking , alcohol drinking , physical activity , diet and being overweight or obese ) and  incident type 2 diabetes and risk of health outcomes among diabetic individuals .
Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses
Abstract Objectives To prospect ively evaluate the joint association of duration of rotating night shift work and lifestyle factors with risk of type 2 diabetes risk , and to quantitatively decompose this joint association to rotating night shift work only , to lifestyle only , and to their interaction . Design Prospect i ve cohort study . Setting Nurses ’ Health Study ( 1988 - 2012 ) and Nurses ’ Health Study II ( 1991 - 2013 ) . Participants 143 410 women without type 2 diabetes , cardiovascular disease , or cancer at baseline . Exposures Rotating night shift work was defined as at least three night shifts per month in addition to day and evening shifts in that month . Unhealthy lifestyles included current smoking , physical activity levels below 30 minutes per day at moderate to vigorous intensity , diet in the bottom three fifths of the Alternate Healthy Eating Index score , and body mass index of 25 or above . Main outcome measures Incident cases of type 2 diabetes were identified through self report and vali date d by a supplementary question naire . Results During 22 - 24 years of follow-up , 10 915 cases of incident type 2 diabetes occurred . The multivariable adjusted hazard ratios for type 2 diabetes were 1.31 ( 95 % confidence interval 1.19 to 1.44 ) per five year increment of duration of rotating night shift work and 2.30 ( 1.88 to 2.83 ) per unhealthy lifestyle factor ( ever smoking , low diet quality , low physical activity , and overweight or obesity ) . For the joint association of per five year increment rotating night shift work and per unhealthy lifestyle factor with type 2 diabetes , the hazard ratio was 2.83 ( 2.15 to 3.73 ) with a significant additive interaction ( P for interaction < 0.001 ) . The proportions of the joint association were 17.1 % ( 14.0 % to 20.8 % ) for rotating night shift work alone , 71.2 % ( 66.9 % to 75.8 % ) for unhealthy lifestyle alone , and 11.3 % ( 7.3 % to 17.3 % ) for their additive interaction . Conclusions Among female nurses , both rotating night shift work and unhealthy lifestyle were associated with a higher risk of type 2 diabetes . The excess risk of rotating night shift work combined with unhealthy lifestyle was higher than the addition of risk associated with each individual factor . These findings suggest that most cases of type 2 diabetes could be prevented by adhering to a healthy lifestyle , and the benefits could be greater in rotating night shift workers
The associations were largely consistent and significant among individuals from different socioeconomic background s and baseline characteristics .
Conclusions /interpretationAdoption of a healthy lifestyle is associated with substantial risk reduction in type 2 diabetes and long-term adverse outcomes among diabetic individuals .
Aims /hypothesisA healthy lifestyle has been widely recommended for the prevention and management of type 2 diabetes .
However , no systematic review has summarised the relationship between combined lifestyle factors ( including , but not limited to , smoking , alcohol drinking , physical activity , diet and being overweight or obese ) and  incident type 2 diabetes and risk of health outcomes among diabetic individuals .