Exercise , particularly aerobic exercise , had a significant effect on serum leptin and a possible influence on adiponectin levels , suggesting its therapeutic implication
Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals ; however , results to date are controversial .
Here we performed a systematic review and meta- analysis of the available r and omized controlled trials ( RCTs ) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals .
Low serum adiponectin predicts 10-year risk of type 2 diabetes and HbA1c independently of obesity, lipids, and inflammation: Whitehall II study.
Our aim of the present work was to study the effect of  serum adiponectin on incident diabetes and HbA1c values . We measured baseline serum adiponectin levels in a nested case-control selection ( n=140 ) of the Whitehall II Cohort . Participants ( mean [ SD ] age 50.9 [ 6.3 ] years ) had no prevalent diabetes or CHD at baseline . Cases ( n=55 ) had incident diabetes according to an oral glucose tolerance test during follow-up ( mean : 11.5+/-3.0 years ) . Adiponectin levels were lower among cases ( 9.3 microg/ml , 3.2 [ median ; IQR ] vs. 10.5 ; 3.6 , p=0.01 ) . The risk of incident diabetes decreased by 11 % ( p=0.03 ) for 1 microg/ml higher adiponectin levels . Higher adiponectin levels were associated with lower HbA1c at follow-up ( p<0.05 ) . Both associations were stable to adjustment for age , sex , body mass index , systolic blood pressure , and serum lipids , and for the case of HbA1c , also for C-reactive protein ( all p<0.05 ) . The observed robust , prospect i ve associations support that  adiponectin  is an independent predictor of diabetes and the degree of glycaemic impairment
Exercise , particularly aerobic exercise , had a significant effect on serum leptin and a possible influence on adiponectin levels , suggesting its therapeutic implication
Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals ; however , results to date are controversial .
Here we performed a systematic review and meta- analysis of the available r and omized controlled trials ( RCTs ) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals .