Meta- analysis of RCTs showed that only cyclosporine A provided a simultaneous great effect size of SMD on ICSI , pain , and frequency .
Amitriptyline at different dosages showed a great effect size of SMD on pain and urgency or on ICSI and frequency .
The results from the n RCTs showed that the most frequently adopted treatment is oral pentosan polysulfate and that the use of botulinum A toxin intradetrusorial injections in PBS/IC is increasing .
Limited evidence exists for the few treatments for PBS/IC .
The lack of definitive conclusions is due to the great heterogeneity in methodology , symptoms assessment , duration of treatment , and follow-up in both RCTs and n RCTs
CONTEXT Different types of behavioural , dietary , interventional , pharmacologic , and surgical therapies have been used to treat painful bladder syndrome/interstitial cystitis ( PBS/IC ) .
Because of the paucity of r and omised placebo-controlled studies on different treatments , an evidence -based management approach has not yet been developed .
OBJECTIVE To critically review and synthesize data from a wide range of current therapeutic approaches to PBS/IC , to quantify the effect size from r and omised controlled trials ( RCTs ) , and to reach clinical agreement on the efficacy of treatments for PBS/IC .
Modified Thiele massage as therapeutic intervention for female patients with interstitial cystitis and high-tone pelvic floor dysfunction.
OBJECTIVES To evaluate the effectiveness of transvaginal manual therapy of the pelvic floor musculature ( Thiele massage ) in symptomatic female patients with interstitial cystitis and high-tone dysfunction of the pelvic floor . METHODS A total of 21 women with documented interstitial cystitis and high-tone pelvic floor dysfunction underwent transvaginal massage using the Thiele technique twice a week for 5 weeks . Symptoms were evaluated before massage , at protocol conclusion , and at a mean of 4.5 months after therapy completion ( long-term follow-up ) . The response to treatment was evaluated through the O'Leary-Sant Interstitial Cystitis Symptom and Problem Indexes , Likert Visual Analogue Scales for urgency and pain , and Short-Form 12-item ( SF-12 ) Quality -of-Life Scale , and through changes in the physical examination findings using a 5-point modified Oxford Scale to document pelvic floor tenderness . RESULTS A statistically significant improvement was seen in the Symptom and Problem Indexes of the O'Leary-Sant Question naire ( P = 0.015 and P = 0.039 , respectively ) , Likert Visual Analogue Scales for urgency and pain ( P = 0.001 and P = 0.005 , respectively ) , the Physical and Mental Component Summary from the SF-12 Quality -of-Life Scale ( P = 0.049 and P = 0.044 , respectively ) , and the modified Oxford Scale ( P < 0.05 ) after protocol completion . At long-term follow-up , the O'Leary-Sant Interstitial Cystitis Symptom and Problem Indexes ( P = 0.049 and P = 0.02 , respectively ) , Likert Visual Analogue Scales for urgency and pain ( P = 0.004 and P = 0.005 , respectively ) , and modified Oxford Scale for three of four muscles in the pelvic floor ( P < 0.05 ) remained significantly improved . CONCLUSIONS Thiele massage appears to be very helpful in improving irritative bladder symptoms in patients with interstitial cystitis and high-tone pelvic floor dysfunction in addition to decreasing pelvic floor muscle tone
Meta- analysis of RCTs showed that only cyclosporine A provided a simultaneous great effect size of SMD on ICSI , pain , and frequency .
Amitriptyline at different dosages showed a great effect size of SMD on pain and urgency or on ICSI and frequency .
The results from the n RCTs showed that the most frequently adopted treatment is oral pentosan polysulfate and that the use of botulinum A toxin intradetrusorial injections in PBS/IC is increasing .
Limited evidence exists for the few treatments for PBS/IC .
The lack of definitive conclusions is due to the great heterogeneity in methodology , symptoms assessment , duration of treatment , and follow-up in both RCTs and n RCTs
CONTEXT Different types of behavioural , dietary , interventional , pharmacologic , and surgical therapies have been used to treat painful bladder syndrome/interstitial cystitis ( PBS/IC ) .
Because of the paucity of r and omised placebo-controlled studies on different treatments , an evidence -based management approach has not yet been developed .
OBJECTIVE To critically review and synthesize data from a wide range of current therapeutic approaches to PBS/IC , to quantify the effect size from r and omised controlled trials ( RCTs ) , and to reach clinical agreement on the efficacy of treatments for PBS/IC .