( S ) Few studies of medical therapies for endometriosis report outcomes that are relevant to patients , and many women gain only limited or intermittent benefit from treatment
OBJECTIVE To assess patient response rates to medical therapies used to treat endometriosis-associated pain .
Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis.
OBJECTIVE To evaluate the efficacy of the GnRH agonist ( GnRH-a ) nafarelin compared with placebo administered for 6 months after reductive laparoscopic surgery for symptomatic endometriosis . DESIGN R and omized , prospect i ve , placebo-controlled , multicenter clinical trial . SETTING Thirteen clinics including private practice and university centers . PATIENT(S ) One hundred nine women aged 18 - 47 with laparoscopically proven endometriosis and pelvic pain who had undergone reductive laparoscopic surgery for endometriosis . INTERVENTION(S ) Patients were r and omized to receive either the GnRH-a nafarelin ( 200 micrograms twice daily ) or placebo for 6 months . MAIN OUTCOME MEASURE(S ) Time to initiation of alternative treatment ( the length of time from beginning study medication to receiving alternative therapy or to deeming that the study drug was ineffective ) and patient-reported and physician-assessed pelvic pain scores . RESULT ( S ) The median time to initiation of alternative treatment was > 24 months in the nafarelin group versus 11.7 months in the placebo group . Fifteen ( 31 % ) of 49 nafarelin-treated patients required alternative therapy , compared with 25 ( 57 % ) of 44 placebo-treated patients . The patients ' pelvic pain scores dropped significantly in the nafarelin and placebo groups after 6 months of treatment . Physician summary ratings showed significant improvement in the nafarelin group and no significant changes in the placebo group after 6 months of treatment . CONCLUSION ( S ) Compared with placebo , nafarelin administered after reductive laparoscopic surgery for endometriosis significantly delays the return of endometriosis symptoms requiring further treatment
( S ) Few studies of medical therapies for endometriosis report outcomes that are relevant to patients , and many women gain only limited or intermittent benefit from treatment
OBJECTIVE To assess patient response rates to medical therapies used to treat endometriosis-associated pain .