When comparing NNS vs sucrose , significant weight/ BMI differences appeared favouring NNS .
Consumption of NNS led to significantly negative weight/ BMI differences in unrestricted energy diets , but not in weight-reduction diets .
Participants with overweight/obesity and adults showed significant favourable weight/ BMI differences with NNS .
Data suggest that replacing sugar with NNS leads to weight reduction , particularly in participants with overweight/obesity under an unrestricted diet , information that could be utilized for evidence -based public policy decisions
There is an ongoing debate about the possible influences of nonnutritive sweeteners ( NNS ) on body weight .
We conducted a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) with NNS to assess their impact on body weight .
Effects of replacing diet beverages with water on weight loss and weight maintenance: 18-month follow-up, randomized clinical trial
Background : Beneficial effects of replacing diet beverages ( DBs ) with water on weight loss , during a 24-week hypoenergetic diet were previously observed . However , it is not known whether this difference is sustained during a subsequent 12-month weight maintenance period . Objective : To evaluate effects of replacing DBs with water on body weight maintenance over a 12-month period in participants who undertook a 6-month weight loss plan . Design : Seventy-one obese and overweight adult women ( body mass index ( BMI ): 27–40 kg m–2 ; age : 18–50 years ) who usually consumed DBs in their diet were r and omly assigned to either substitute water for DBs ( water group : 35 ) or continue drinking DBs five times per week ( DBs group : 36 ) after their lunch for the 6-month weight loss intervention and subsequent 12-month weight maintenance program . Results : A total of 71 participants who were r and omly assigned were included in the study by using an intention-to-treat analysis . Greater additional weight loss ( mean±s.d . ) in the water group was observed compared with the DBs group after the 12-month follow-up period ( −1.7±2.8 vs −0.1±2.7 kg , P=0.001 ) . BMI decreased more in the water group than in the DBs group ( −0.7±1 vs −0.05±1.1 kg m–2 , P=0.003 ) . There was also a greater reduction in fasting insulin levels ( −0.5±1.4 vs −0.02±1.5 mmol l–1 , P=0.023 ) , better improvement in homeostasis model assessment of insulin resistance ( −0.2±0.4 vs −0.1±0.3 , P=0.013 ) and a greater decrease in 2-h postpr and ial plasma glucose ( −0.2±0.3 vs −0.1±0.3 mmol l–1 , P<0.001 ) in the water group compared with the DBs over the 12-month weight maintenance period . Conclusions : Replacement of DBs with water after the main meal in women who were regular users of DBs may cause further weight reduction during a 12-month weight maintenance program . It may also offer benefits in carbohydrate metabolism including improvement of insulin resistance over the long-term weight maintenance period
When comparing NNS vs sucrose , significant weight/ BMI differences appeared favouring NNS .
Consumption of NNS led to significantly negative weight/ BMI differences in unrestricted energy diets , but not in weight-reduction diets .
Participants with overweight/obesity and adults showed significant favourable weight/ BMI differences with NNS .
Data suggest that replacing sugar with NNS leads to weight reduction , particularly in participants with overweight/obesity under an unrestricted diet , information that could be utilized for evidence -based public policy decisions
There is an ongoing debate about the possible influences of nonnutritive sweeteners ( NNS ) on body weight .
We conducted a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) with NNS to assess their impact on body weight .