None of the interventions were significantly better than the others in lowering glucose parameters .
The Mediterranean diet reduced HbA1c significantly compared to usual care but not compared to the Palaeolithic diet .
The effect of alterations in dietary practice irrespective of weight loss on glycaemic control can not be concluded from the present review .
BACKGROUND Overweight or obese individuals with type 2 diabetes are encouraged to lose weight for optimal glucose management , yet many find this difficult .
Determining whether alterations in dietary patterns irrespective of weight loss can aid glucose control has not been fully investigated .
METHODS We conducted a systematic review and meta- analysis aim ing to determine the effects of a Mediterranean diet compared to other dietary interventions on glycaemic control irrespective of weight loss .
The Hawthorne Effect: a randomised, controlled trial
Background The ' Hawthorne Effect ' may be an important factor affecting the generalisability of clinical research to routine practice , but has been little studied . Hawthorne Effects have been reported in previous clinical trials in dementia but to our knowledge , no attempt has been made to quantify them . Our aim was to compare minimal follow-up to intensive follow-up in participants in a placebo controlled trial of Ginkgo biloba for treating mild-moderate dementia . Methods Participants in a dementia trial were r and omised to intensive follow-up ( with comprehensive assessment visits at baseline and two , four and six months post r and omisation ) or minimal follow-up ( with an abbreviated assessment at baseline and a full assessment at six months ) . Our primary outcomes were cognitive functioning ( ADAS-Cog ) and participant and carer-rated quality of life ( QOL-AD ) . Results We recruited 176 participants , mainly through general practice s. The main analysis was based on Intention to treat ( ITT ) , with available data . In the ANCOVA model with baseline score as a co-variate , follow-up group had a significant effect on outcome at six months on the ADAS-Cog score ( n = 140 ; mean difference = -2.018 ; 95%CI -3.914 , -0.121 ; p = 0.037 favouring the intensive follow-up group ) , and on participant-rated quality of life score ( n = 142 ; mean difference = -1.382 ; 95%CI -2.642 , -0.122 ; p = 0.032 favouring minimal follow-up group ) . There was no significant difference on carer quality of life . Conclusion We found that more intensive follow-up of individuals in a placebo-controlled clinical trial of Ginkgo biloba for treating mild-moderate dementia result ed in a better outcome than minimal follow-up , as measured by their cognitive functioning . Trial registration Current controlled trials : IS RCT
None of the interventions were significantly better than the others in lowering glucose parameters .
The Mediterranean diet reduced HbA1c significantly compared to usual care but not compared to the Palaeolithic diet .
The effect of alterations in dietary practice irrespective of weight loss on glycaemic control can not be concluded from the present review .
BACKGROUND Overweight or obese individuals with type 2 diabetes are encouraged to lose weight for optimal glucose management , yet many find this difficult .
Determining whether alterations in dietary patterns irrespective of weight loss can aid glucose control has not been fully investigated .
METHODS We conducted a systematic review and meta- analysis aim ing to determine the effects of a Mediterranean diet compared to other dietary interventions on glycaemic control irrespective of weight loss .