However , benefit was limited to antipsychotics and tricyclic antidepressants .
Conclusions Psychotropic drugs may be an effective treatment for FD , but the effect appears to be limited to antipsychotics and tricyclic antidepressants with fewer trials for other agents , meaning that firm conclusions for efficacy can not be made .
Objective Functional dyspepsia ( FD ) is a chronic gastroduodenal disorder .
Individuals with FD demonstrate visceral hypersensitivity , abnormal central pain processing , and low mood , but it is unclear whether psychotropic drugs are an effective treatment for the condition .
Effects of Amitriptyline on Gastric Sensorimotor Function and Postprandial Symptoms in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
BACKGROUND : Low-dose tricyclic antidepressants have been used to treat chronic somatic and gastrointestinal pain disorders , including refractory functional dyspepsia . However , there are only limited data on the effects of these drugs on upper gastrointestinal function . AIM : To compare the effects of two doses of amitriptyline ( AMT ) and placebo on gastric accommodation , emptying , satiation , and postpr and ial symptoms in healthy volunteers . METHODS : Using a parallel-group , double-blind , placebo-controlled design , 41 healthy volunteers were r and omized to AMT 25 mg , AMT 50 mg , or placebo for 2 wk . During the final 3 days of therapy , the following end points were assessed : fasting and postpr and ial gastric volumes , 2- and 4-h gastric emptying , time and volume to maximum satiation using a nutrient drink test , and postpr and ial symptoms 30 min later using 10-cm visual analog scales . AMT and metabolite levels were measured . RESULTS : AMT slowed gastric emptying at 2 h ( median 75 % for placebo , 57 % for AMT 25 mg , 67 % for AMT 50 mg ; P= 0.037 ) and 4 h ( median 98 % for placebo , 96 % for AMT 25 mg , 92 % for AMT 50 mg ; P= 0.003 ) . AMT did not affect gastric volumes or satiation volume , but it did reduce nausea scores at 30 min in a dose-dependent manner ( median 2.1 for placebo , 0.9 for AMT 25 mg , and 0.0 for AMT 50 mg ; P= 0.009 ) . CONCLUSION : In healthy volunteers , AMT slows gastric emptying of solids , but it does not significantly affect gastric volumes or satiation .  AMT reduces nausea after challenge with a high calorie liquid load
However , benefit was limited to antipsychotics and tricyclic antidepressants .
Conclusions Psychotropic drugs may be an effective treatment for FD , but the effect appears to be limited to antipsychotics and tricyclic antidepressants with fewer trials for other agents , meaning that firm conclusions for efficacy can not be made .
Objective Functional dyspepsia ( FD ) is a chronic gastroduodenal disorder .
Individuals with FD demonstrate visceral hypersensitivity , abnormal central pain processing , and low mood , but it is unclear whether psychotropic drugs are an effective treatment for the condition .