The analysis showed a positive association of adopting the Paleolithic diet in relation to weight loss .
Conclusion The Paleolithic diet may assist in controlling weight and waist circumference and in the management of chronic diseases .
Background The Paleolithic diet has been studied in the scope of prevention and control of chronic noncommunicable diseases ( CNCD ) .
The objective of this study was to analyze the influence of the Paleolithic diet on the prevention and control of CNCD in humans , specifically on anthropometric markers , through a systematic review with meta- analysis .
Methods What is the effect of the Paleolithic diet on anthropometric parameters ( weight , body mass index and waist circumference ) compared to other control diets based on recommendations in adults ?
Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet
Purpose We studied effects of diet-induced postmenopausal weight loss on gene expression and activity of proteins involved in lipogenesis and lipolysis in adipose tissue . Methods Fifty-eight postmenopausal women with overweight ( BMI 32.5 ± 5.5 ) were r and omized to eat an ad libitum Paleolithic-type diet ( PD ) aim ing for a high intake of protein and unsaturated fatty acids or a prudent control diet ( CD ) for 24 months . Anthropometry , plasma adipokines , gene expression of proteins involved in fat metabolism in subcutaneous adipose tissue ( SAT ) and lipoprotein lipase ( LPL ) activity and mass in SAT were measured at baseline and after 6 months . LPL mass and activity were also measured after 24 months . Results The PD led to improved insulin sensitivity ( P < 0.01 ) and decreased circulating triglycerides ( P < 0.001 ) , lipogenesis-related factors , including LPL mRNA ( P < 0.05 ) , mass ( P < 0.01 ) , and activity ( P < 0.001 ) ; as well as gene expressions of CD36 ( P < 0.05 ) , fatty acid synthase , FAS ( P < 0.001 ) and diglyceride acyltransferase 2 , DGAT2 ( P < 0.001 ) . The LPL activity ( P < 0.05 ) and gene expression of DGAT2 ( P < 0.05 ) and FAS ( P < 0.05 ) were significantly lowered in the PD group versus the CD group at 6 months and the LPL activity ( P < 0.05 ) remained significantly lowered in the PD group compared to the CD group at 24 months . Conclusions Compared to the CD , the PD led to a more pronounced reduction of lipogenesis-promoting factors in SAT among postmenopausal women with overweight . This could have mediated the favorable metabolic effects of the PD on triglyceride levels and insulin sensitivity
The analysis showed a positive association of adopting the Paleolithic diet in relation to weight loss .
Conclusion The Paleolithic diet may assist in controlling weight and waist circumference and in the management of chronic diseases .
Background The Paleolithic diet has been studied in the scope of prevention and control of chronic noncommunicable diseases ( CNCD ) .
The objective of this study was to analyze the influence of the Paleolithic diet on the prevention and control of CNCD in humans , specifically on anthropometric markers , through a systematic review with meta- analysis .
Methods What is the effect of the Paleolithic diet on anthropometric parameters ( weight , body mass index and waist circumference ) compared to other control diets based on recommendations in adults ?