Sensitivity analyses and meta-regression for hemoglobin suggested a higher response with lower trial quality ( suboptimal allocation concealment and blinding ) , use of condiments , and sodium iron edetate and a lower response when adults were included .
Consumption of iron-fortified foods results in an improvement in hemoglobin , serum ferritin , and iron nutriture and a reduced risk of remaining anemic and iron deficient
BACKGROUND The utility of iron fortification of food to improve iron deficiency , anemia , and biological outcomes is not proven unequivocally .
[Intake of an iron-supplemented milk formula as a preventive measure to avoid low iron status in 1-3 year-olds].
OBJECTIVE Low iron status is a well known risk factor for iron deficiency anemia in infants and young children . The aim of the present study was to evaluate the influence of an iron-fortified toddler formula on iron status in 1 - 3 year-olds . PATIENTS AND METHODS Thirty-three healthy infants and young children were assigned to two groups that received 500 mL/day of and iron-fortified toddler formula or 500 mL/day of unmodified cow 's milk for 4 months . Allocation was r and om and double-blind . Daily dietary intake was calculated by dietary evaluation , and iron nutritional status was assessed ( hemoglobin , hematocrit , mean corpuscular volume , mean corpuscular hemoglobin , mean corpuscular hemoglobin concentration , serum iron , ferritin , and transferrin ) . RESULTS At enrollment , no anemia was found in either group , although hemoglobin concentration and hematocrit were significantly lower in the toddler formula group than in the unmodified cow 's milk group . However , these differences disappeared at the end of the intervention period . After 4 months , the toddler formula group showed significantly higher serum ferritin and lower serum transferrin concentrations than the cow 's milk group . CONCLUSION Intake of iron-supplemented toddler formula for 4 months in 1 - 3 year-olds is more effective in maintaining iron nutritional status than cow 's milk
Sensitivity analyses and meta-regression for hemoglobin suggested a higher response with lower trial quality ( suboptimal allocation concealment and blinding ) , use of condiments , and sodium iron edetate and a lower response when adults were included .
Consumption of iron-fortified foods results in an improvement in hemoglobin , serum ferritin , and iron nutriture and a reduced risk of remaining anemic and iron deficient
BACKGROUND The utility of iron fortification of food to improve iron deficiency , anemia , and biological outcomes is not proven unequivocally .