TSA indicated lack of firm evidence for the results of the meta‐analytic outcomes on clinical and radiographic success .
Conclusion BD and MTA have similar clinical and radiographic success rates based on limited and low‐ quality evidence .
Objectives Pulpotomy is the favored treatment for pulp exposure in carious primary teeth .
This review aim ed to compare the success rates of biodentine ( BD ) and mineral trioxide aggregate ( MTA ) pulpotomies  in primary molars using meta‐ analysis ( MA ) and trial sequential analysis ( TSA ) and also to assess the quality of the results by Grading of Recommendations , Assessment , Development and Evaluation ( GRADE ) .
Mineral Trioxide Aggregate vs. Calcium Hydroxide in Primary Molar Pulpotomy: A Systematic Review
Introduction : The aim of this quantitative systematic review /meta- analysis was to compare the treatment outcomes of mineral trioxide aggregate ( MTA ) and calcium hydroxide ( CH ) in pulpotomy of human primary molars . The focused PICO question was “ in case of pulp exposure in vital primary molars , how does MTA pulpotomy compare to CH in terms of clinical /radiographic success ? ” Methods and Material s : We retrieved published r and omized clinical trials ( RCTs ) of at least 6-month duration ; our search included articles published up to March 2013 in five following data bases : PubMed ( Medline ) , Cochrane data base of systematic review s , Science Citation Index , EMBASE , and Google Scholar . Mantel Haenszel and Inverse Variance-weighted methods were applied by STATA ; the relative risk ( RR ) was calculated with 95 % confidence intervals ( CI ) . Results : A total of 282 English articles were collected . Two authors independently screened the articles and five RCTs were selected ; data extraction and quality assessment were then carried out . Four RCTs were appropriate for meta- analysis according to their follow-up times by Mantel Haenszel method . Statistically significant difference was found between success rate of MTA compared to CH , with RR=0.08 ( 95 % CI , 0.02 - 0.39 ) , RR=0.19 ( 95 % CI , 0.08 - 0.46 ) , and RR=0.38 ( 95 % CI , 0.21 - 0.68 ) for 6- , 12- , and 24-month follow-ups , respectively . A significant difference was also observed for all included RCTs after analyses using the Inverse Variance-weighted method ( RR=0.44 ; 95 % CI , 0.27 - 0.72 ) . Conclusions : Systematic review /meta- analysis of included RCTs revealed that for pulpotomy of vital primary molars , MTA has better treatment outcomes compared to CH
TSA indicated lack of firm evidence for the results of the meta‐analytic outcomes on clinical and radiographic success .
Conclusion BD and MTA have similar clinical and radiographic success rates based on limited and low‐ quality evidence .
Objectives Pulpotomy is the favored treatment for pulp exposure in carious primary teeth .
This review aim ed to compare the success rates of biodentine ( BD ) and mineral trioxide aggregate ( MTA ) pulpotomies  in primary molars using meta‐ analysis ( MA ) and trial sequential analysis ( TSA ) and also to assess the quality of the results by Grading of Recommendations , Assessment , Development and Evaluation ( GRADE ) .