RESULTS Body cell mass was correlated with all measures of performance at baseline .
Growth hormone significantly reduced fat mass , increased lean body mass through an increase in extracellular water , and increased body cell mass in men when coadministered with testosterone .
Growth hormone supplementation influenced body composition and increased sprint capacity when administered alone and in combination with testosterone .
BACKGROUND Growth hormone is widely abused by athletes , frequently with and rogenic steroids .
Its effects on performance are unclear .
OBJECTIVE To determine the effect of growth hormone alone or with testosterone on body composition and measures of performance .
Treatment with human growth hormone in patients with Prader-Labhart-Willi syndrome reduces body fat and increases muscle mass and physical performance
Twelve children with documented Prader-Labhart-Willi syndrome were treated with human growth hormone ( 24 U/m2/week ) during 1 year . The children were divided into three groups : group 1 : overweight and prepubertal ( n = 6 , age 3.8–7.0 years ) ; group 2 : underweight and prepubertal ( n = 3 , age 0.6–4.1 years ) ; group 3 : pubertal ( n = 3 , age 9.2–14.6 years ) . In group 1 , height increased from -1.7 SD to -0.6 SD , while weight decreased from 1.1 SD to 0.4 SD , with a dramatic drop in weight for height from 3.8 SD to 1.2 SD . H and length increased from -1.5 SD to -0.4 SD and foot length from -2.5 SD to -1.4 SD . Body fat , measured by dual X-ray energy absorptiometry , dropped by a third , whereas muscle mass increased by a fourth . Physical capability ( Wingate test ) improved considerably . The children were reported to be much more active and capable . In group 2 , similar changes were seen , but weight for height increased , probably because muscle mass increase exceeded fat mass decrease . Changes in group 3 were similar as in group 1 , even though far less distinct . Conclusion Growth hormone treatment in Prader-Labhart-Willi syndrome led to dramatic changes : distinct increase in growth velocity , height and muscle mass , as well as an improvement in physical performance . Fat mass and weight for height decreased in the initially overweight children , and weight for height increased in underweight children
RESULTS Body cell mass was correlated with all measures of performance at baseline .
Growth hormone significantly reduced fat mass , increased lean body mass through an increase in extracellular water , and increased body cell mass in men when coadministered with testosterone .
Growth hormone supplementation influenced body composition and increased sprint capacity when administered alone and in combination with testosterone .
BACKGROUND Growth hormone is widely abused by athletes , frequently with and rogenic steroids .
Its effects on performance are unclear .
OBJECTIVE To determine the effect of growth hormone alone or with testosterone on body composition and measures of performance .