For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .
Efficacy and safety of oral sildenafil in the treatment of erectile dysfunction: a double-blind, placebo-controlled study of 329 patients. Sildenafil Study Group.
The efficacy and safety of oral sildenafil citrate for the treatment of erectile dysfunction ( ED ) were assessed in a 12-week placebo-controlled study . Men with ED of organic , psychogenic , or mixed aetiology were r and omised to placebo  ( n = 166 ) or 50 mg sildenafil ( n = 163 ) , with adjustment to 100 mg or 25 mg based on efficacy and tolerability . Efficacy assessment s included a global efficacy question , event log data , and an optional partner question naire . At the end of the study , improved erections were reported by 74 % of patients receiving sildenafil versus 16 % for placebo ( p < 0.0001 ) . In the final 4 weeks of treatment , 65 % of all attempts at sexual intercourse were successful for all patients ( responders and non-responders ) receiving sildenafil versus 20 % for placebo ( p < 0.001 ) . The mean number of successful attempts per month was 5.9 for patients receiving sildenafil versus 1.5 for those receiving placebo ( p < 0.0001 ) . The most common adverse events -- headache , flushing , and dyspepsia -- were generally mild to moderate in nature and rarely ( < 1 % ) a reason for discontinuation of treatment . Oral sildenafil is an effective , reliable and well-tolerated treatment for ED of organic , psychogenic or mixed aetiology
For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .