There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Long-chain polyunsaturated fatty acids have a positive effect on the quality of general movements of healthy term infants.
BACKGROUND Whether long-chain polyunsaturated fatty acids ( LCPs ) play a role in the development of the young nervous system in term infants is debated . OBJECTIVE We investigated whether supplementation of formula with LCPs for 2 mo improves the quality of general movements ( GMs ) in healthy term infants at 3 mo of age . DESIGN A prospect i ve , double-blind , r and omized controlled study was conducted with 2 groups of healthy term infants : a control-formula ( CF ) group ( n = 131 ) and an LCP-supplemented-formula ( LF ) group ( n = 119 ) . A breastfed ( BF ) group ( n = 147 ) served as a reference . Information on potential confounders was collected at enrollment . Videotapes were made of the infants ' spontaneous motor behavior at 3 mo of age to assess the quality of their GMs . On the basis of quality , normal GMs were classified as normal-optimal or normal-suboptimal , and abnormal GMs were classified as mildly or definitely abnormal . Attrition at 3 mo of age was 15 % and nonselective . Multivariate regression analyses with adjustment for confounders were carried out to evaluate the effect of the type of feeding . RESULTS None of the infants had definitely abnormal GMs . Infants in the CF group had mildly abnormal GMs significantly more often than did infants in the LF and BF groups ( 31 % compared with 19 % and 20 % , respectively ) . Infants in the BF group had normal-optimal GMs more frequently than did infants in the LF and CF groups ( 34 % compared with 18 % and 21 % , respectively ) . Logistic regression analyses confirmed these findings . CONCLUSION Supplementation of healthy term infants with LCPs during the first 2 mo of life reduces the occurrence of mildly abnormal GMs
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .