We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
The effect of maternal avoidance of eggs, cow's milk, and fish during lactation on the development of IgE, IgG, and IgA antibodies in infants.
Serum levels of IgE , IgE antibodies to egg white ( EW ) and cow 's milk ( CM )  , IgG , and IgA antibodies to ovalbumin ( OA ) and beta-lactoglobulin ( BLG ) were measured in a group of 115 infants with a family history of atopy/allergy at birth and at 3 , 6 , 9 , 12 , and 18 months of age . The mothers of 65 infants  avoided eggs , CM , and fish during the first 3 months of lactation ( maternal antigen avoidance diet , D group ) , whereas the remaining 50 mothers  had no diet restrictions ( no maternal antigen avoidance diet , ND group ) . CM was introduced after 6 months of age and EW after 9 months . The only statistically significant difference between the D and ND group infants was a lower rate of specimens with IgE antibodies to EW and /or CM in the infants at 3 months of age ( p = 0.008 ) . IgE antibodies to EW and /or CM appeared in 62 infants during the study period and often during complete breast-feeding . In 40 of the infants , IgE antibodies appeared before the introduction of EW and CM into the diet . The IgE concentrations of the D and the ND group infants were similar . Cord-blood IgE was a poor predictor of atopy/allergy ; for example , only seven of 103 infants with double heredity for atopy/allergy had values above the 90th percentile of our normal reference . The concentrations of IgG antibodies to OA and BLG were similar in the two groups . The levels decreased significantly ( p less than 0.001 ) from birth to 6 months of age , indicating a passive placental transfer . ( ABSTRACT TRUNCATED AT 250 WORDS
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .