SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .
Accelerating symptom-reduction in late-life depression: a double-blind, randomized, placebo-controlled trial of sleep deprivation.
OBJECTIVE Authors tested the hypothesis that one night of total sleep deprivation ( TSD ) would accelerate antidepressant response to paroxetine , as compared with TSD+placebo ( PBO ) and paroxetine-alone , in late-life major depression . METHODS Eighty elderly out patients with current episodes of non-psychotic , non-bipolar major depression were r and omly assigned to one of three treatment conditions : TSD+paroxetine ( N = 27 ) , TSD + PBO ( N = 27 ) , and paroxetine-only ( N = 26 ) . Primary outcome was percentage of subjects in each condition who demonstrated early response ( Hamilton Rating Scale for Depression scores [ Ham-D : 17-item ] of < or = 10 ) or remission ( score of < or = 7 ) on Day 14 . RESULTS Response rates after 14 days were 22 % in subjects r and omly assigned to the TSD + paroxetine condition , 41 % in TSD + PBO , and 46 % in paroxetine alone . Remission rates after 14 days were 11 % in TSD+paroxetine , 22 % in TSD + PBO , and 38 % in paroxetine . After adjusting for baseline depression severity , there were no statistically significant differences in response or remission rates . CONCLUSION Contrary to the study hypothesis , one night of total sleep deprivation did not accelerate onset of antidepressant response to paroxetine pharmacotherapy of late-life depression . The data suggest , rather , that the two interventions might have counteracted each other
SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .