Our data suggested that N.S supplementation had significant impacts on liver and kidney parameters leading to a decrease in ALP and BUN levels .
The aim of this systematic review and dose-response meta- analysis was to determine the effect of Nigella Sativa ( N.S ) supplementation on  liver and kidney parameters .
Preliminary safety evaluation and biochemical efficacy of a Carum carvi extract: results from a randomized, triple-blind, and placebo-controlled clinical trial.
Carum carvi L. ( Apiaceae ) is known as caraway , and its derivatives find wide medicinal use for health purpose s , including for gastrointestinal problems and obesity . Since there is inconsistency among the reports on the safety of this plant in humans , this research was aim ed at assessing the safety of a characterized caraway aqueous extract ( CAE ) in a r and omized , triple-blind , placebo-controlled study . Seventy , overweight and obese , healthy women were r and omly assigned into placebo ( n = 35 ) and plant extract ( n = 35 ) groups . Participants received either 30 ml/day of CAE or placebo . Subjects were examined at baseline and after 12 weeks for changes in heart rate , blood pressure , urine test , 25-item blood chemistries , and general health status . No significant changes of blood pressure , heart rate , urine specific gravity , and serum blood tests were observed between the two groups before and after treatment . However , in the complete blood count test , red blood cell levels were significantly ( p < 0.01 ) increased , and platelet distribution width was significantly decreased after the dietary CAE treatment , as compared with placebo . No negative changes were observed in the general health status of the two groups . This preliminary study suggests that the oral intake of CAE appears to be without any adverse effects at a dosage of 30 ml daily for a period of 12 weeks
Our data suggested that N.S supplementation had significant impacts on liver and kidney parameters leading to a decrease in ALP and BUN levels .
The aim of this systematic review and dose-response meta- analysis was to determine the effect of Nigella Sativa ( N.S ) supplementation on  liver and kidney parameters .