“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .
Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial.
BACKGROUND Some studies have suggested reductions in blood pressure (BP)with statin treatment , particularly in persons with hypertension . R and omized trial evidence is limited . METHODS We performed a r and omized , double-blind , placebo-controlled trial with equal allocation to simvastatin , 20 mg ; pravastatin sodium,40 mg ; or placebo for 6 months . Nine hundred seventy-three men and women without known cardiovascular disease or diabetes mellitus , with low-density lipoprotein cholesterol screening levels of 115 to 190 mg/dL , had assessment of systolic and diastolic BP ( SBP and DBP , respectively ) .  Blood pressure values were compared for placebo vs statins by intention-to-treat ( ITT ) analysis . Additional analyses were performed that ( 1 ) were confined to subjects with neither high baseline BP ( SBP>140 mm Hg or DBP>90 mm Hg ) nor receiving BP medications , to exclude groups in whom BP medications or medication changes may have influenced results , and ( 2 ) separately evaluated simvastatin and pravastatin ( vs placebo ) . The time course of BP changes after statin initiation and the effect of stopping statins on BP were examined . RESULTS Statins modestly but significantly reduced BP relative to placebo , by 2.2 mm Hg for SBP ( P=.02 ) and 2.4 mm Hg for DBP ( P<.001 ) in ITT analysis . Blood pressure reductions ranged from 2.4 to 2.8 mm Hg for both SBP and DBP with both simvastatin and pravastatin , in those subjects with full follow-up , and without potential for influence by BP medications ( ie , neither receiving nor meriting BP medications ) . CONCLUSIONS Reductions in SBP and DBP occurred with hydrophilic and lipophilic statins and extended to normotensive subjects . These modest effects may contribute to the reduced risk of stroke and cardiovascular events reported on statins . Trial Registration clinical trials.gov Identifier : NCT00330980
“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .