Conclusions The effects of testosterone on cardiovascular-related events varied with source of funding .
Nevertheless , overall and particularly in trials not funded by the pharmaceutical industry , exogenous testosterone increased the risk of cardiovascular-related events , with corresponding implication s for the use of testosterone therapy
Background Testosterone therapy is increasingly promoted .
No r and omized placebo-controlled trial has been implemented to assess the effect of testosterone therapy on cardiovascular events , although very high levels of and rogens are thought to promote cardiovascular disease .
Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens.
Studies on regional differences of adipose tissue metabolism have mainly been performed in vitro . To allow measurements of lipid uptake in vivo in man , radioactive label from [9,10 - 3H]oleic acid in 80 g orally administered milk fat was measured after 4 h in abdominal and femoral sc adipose tissues in 28 middle-aged , abdominally obese men . Radioactivity was measured in adipose tissue triglycerides extracted from needle biopsies . Lipoprotein lipase ( LPL ) activity was also measured . Uptake of label in triglycerides and LPL activity were higher ( 20 % and 15 % , respectively ; P < 0.05 ) in the abdominal compared to the femoral adipose tissue region . The men were then r and omly assigned to three groups , receiving testosterone ( T ) , dihydrotestosterone , or placebo , for 9 months . After 2 months of treatment , the procedure of administration of label was repeated , this time using [U-14C]oleic acid as a marker . Measurements of radioactive label was then performed after 4 h and monthly up to 7 months . Supplementation with T was followed by an inhibited uptake of label in triglycerides ( 34 % ; P < 0.05 ) , lower LPL activity ( 48 % ; P < 0.05 ) , and a shorter t1/2 ( 30 % ; P < 0.05 ) in the abdominal adipose tissue region compared with the dihydrotestosterone and placebo groups . No significant effect of T on triglyceride uptake , LPL activity , or t1/2 was found in sc femoral adipose tissue . It was concluded that the turnover rate of depot triglycerides is more rapid in abdominal compared to femoral sc adipose tissue in men . Furthermore , T supplementation inhibits triglyceride uptake and LPL activity and causes a more rapid turnover of triglycerides only in the sc abdominal adipose tissue region . These results demonstrate the marked effects of T on adipose tissue metabolism in vivo and suggest that T is an important regulator of the proportion of depot fat mass in central and peripheral adipose tissue in men
Conclusions The effects of testosterone on cardiovascular-related events varied with source of funding .
Nevertheless , overall and particularly in trials not funded by the pharmaceutical industry , exogenous testosterone increased the risk of cardiovascular-related events , with corresponding implication s for the use of testosterone therapy
Background Testosterone therapy is increasingly promoted .
No r and omized placebo-controlled trial has been implemented to assess the effect of testosterone therapy on cardiovascular events , although very high levels of and rogens are thought to promote cardiovascular disease .