Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Cardioprotective Effects of Short-Term Caloric Restriction Are Mediated by Adiponectin via Activation of AMP-Activated Protein Kinase
Background — Overeating and obesity are major health problems in developed countries . Caloric restriction ( CR ) can counteract the deleterious aspects of obesity-related diseases and prolong lifespan . We have demonstrated that short-term CR improves myocardial ischemic tolerance and increases adiponectin levels . Here , we investigated the specific role of adiponectin in CR-induced cardioprotection . Methods and Results — Adiponectin antisense transgenic ( Ad-AS ) mice and wild-type ( WT ) mice were r and omly assigned to a group fed ad libitum and a CR group ( 90 % of caloric intake of ad libitum for 3 weeks , then 65 % for 2 weeks ) . Isolated perfused mouse hearts were subjected to 25 minutes of ischemia , followed by 60 minutes of reperfusion . CR increased serum adiponectin levels by 84 % in WT mice . Gel filtration analysis of the oligomeric complex distribution showed that CR produced a marked increase in the high – molecular-weight complex of adiponectin in WT mice ; in contrast , CR did not change serum adiponectin levels or their oligomeric pattern in Ad-AS mice . CR improved the recovery of left ventricular function after ischemia/reperfusion and limited infa rct size in WT mice ; these effects were completely abrogated in Ad-AS mice . CR also increased the phosphorylated form of AMP-activated protein kinase and acetyl-CoA carboxylase in WT but not in Ad-AS mice . Recombinant adiponectin restored CR-induced cardioprotection in Ad-AS mice , and inhibition of AMP-activated protein kinase phosphorylation completely abrogated CR-induced cardioprotection in WT mice . Conclusion — The cardioprotective effects of short-term CR are mediated by increased production of adiponectin and the associated activation of AMP-activated protein kinase
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .