Conclusions : Antibiotic prophylaxis did confer a reduction in cases of symptomatic and asymptomatic bacteriuria but the NNT were high .
Introduction : The role of antibiotic prophylaxis for routine flexible cystoscopy ( FC ) is not clear due to the varying practice s of individual clinicians .
There are no formal guidelines , and this may be due to a lack of formal summary of the data .
Safety and tolerability of sedation-free flexible cystoscopy for intradetrusor botulinum toxin-A injection.
PURPOSE Intradetrusor botulinum toxin-A injection is a promising emerging therapy for neurogenic and idiopathic overactive bladder that is refractory to current antimuscarinic agents . We evaluated a sedation-free procedure using flexible endoscopy to perform intradetrusor botulinum toxin-A injection using a vali date d pain score to assess the tolerability of this technique . MATERIAL S AND METHODS Five men and 22 women with idiopathic overactive bladder refractory to antimuscarinics were prospect ively evaluated and r and omized to 100 U ( 14 ) or 150 U botulinum toxin-A ( 13 ) . Subjects underwent BTA injection with intravesical lidocaine using a 14Fr Olympus flexible cystoscope , which accommo date s a 27 gauge flexible Olympus injection needle . Patients were evaluated with the visual analog scale to evaluate discomfort during and 15 minutes after the procedure . Procedure time was recorded . RESULTS In 22 female patients the mean pain score was 3.1 ( range 0 to 10 ) during the procedure and 0.7 ( range 0 to 7 ) 15 minutes after the procedure . In 5 male patients the mean pain score was 1.6 ( range 0 to 3.5 ) during the procedure and 0.0 with all reporting no pain 15 minutes after the procedure . Mean procedure time was 4.5 minutes ( range 4 to 6 ) . Only 1 of the 27 patients requested sedation before any subsequent injections . CONCLUSIONS Sedation-free intradetrusor botulinum toxin-A injection using intravesical lidocaine and flexible endoscopy is a well tolerated and safe procedure to perform in an office setting
Conclusions : Antibiotic prophylaxis did confer a reduction in cases of symptomatic and asymptomatic bacteriuria but the NNT were high .
Introduction : The role of antibiotic prophylaxis for routine flexible cystoscopy ( FC ) is not clear due to the varying practice s of individual clinicians .
There are no formal guidelines , and this may be due to a lack of formal summary of the data .