In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .
Retrospective analysis of locally advanced noninflammatory breast cancer from Chennai, South India, 1990-1999.
PURPOSE This was a retrospective observational study to elicit the outcome of the therapeutic strategy of concurrent neoadjuvant chemoradiotherapy protocol for locally advanced breast cancer . METHODS AND MATERIAL S A large series of 1,117 consecutive cases of locally advanced breast cancer treated at the Cancer Institute ( WIA ) , in Chennai , South India , between 1990 and 1999 and followed through 2004 formed the basis for this study . Disease-free survival was the main outcome , and nodal and tumor downstaging were the intermediate outcome measures studied . RESULTS Primary tumor downstaging was observed in 45 % and nodal downstaging in 57.5 % . The disease-free survival rate of nodal downstaged patients at 5 , 10 , and 15 years was 75 % , 65 % , and 58 % , respectively . The corresponding rates for pre- and postoperative node-negative patients were 70 % , 60 % , and 59 % . The best survival was seen among those who were tumor and node negative postoperatively . Nodal downstaging halved the risk of disease recurrence and death compared with node positivity , irrespective of tumor sterility . CONCLUSIONS A r and omized trial using cyclophosphamide , methotrexate , and 5-fluorouracil vs. an anthracycline-based regimen in the setting of concurrent chemoradiotherapy appears indicated . Additional preoperative chemotherapy to maximize nodal and tumor downstaging should be investigated . A change in postoperative chemotherapy according to nodal status could also be explored
In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .