The evidence supports the WPAI as having test-retest reliability ( reproducibility ) over time ; convergent validity , as indicated by moderate correlations with measures of quality of life and moderate-to-strong correlations with measures of disease activity ; known-groups validity , as indicated by differences in WPAI scores between patients with active and inactive disease ; ability ( sensitivity ) to detect change , as indicated by substantial improvement in scores for patients who achieve remission , accompanied by substantial worsening of scores for patients who relapse ; and , responsiveness to treatment , with improvements in scores following treatments that reduce disease activity .
Patients with ulcerative colitis , a type of inflammatory bowel disease , report negative impacts of disease symptoms on work-related outcomes , including absenteeism and presenteeism .
As a way to better underst and the impact of this disease and its treatment on work-related outcomes , the current review examines the use of the Work Productivity and Activity Impairment Question naire ( WPAI ) , a patient-reported outcomes measure of absenteeism , presenteeism , and impairment in other activities , in studies of patients with ulcerative colitis .
This review assesses the measurement properties of the WPAI in this patient population : its reliability , construct validity , ability to detect change , and responsiveness to effective treatments .
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study.
We assessed oral 5-aminosalicylic acid ( 5-ASA ) prepared with a pH-sensitive polymer coating in 87 patients with mildly to moderately active ulcerative colitis in a double-blind , placebo-controlled trial . Patients were r and omly assigned to receive 5-ASA at a dosage of either 4.8 or 1.6 g per day or placebo for six weeks . The outcome was monitored by flexible proctosigmoidoscopic examinations and physicians ' assessment s at three-week intervals and by patients ' recordings of daily symptoms . Results showed 24 percent complete and 50 percent partial responses in those receiving 4.8 g of 5-ASA per day as compared with 5 percent complete and 13 percent partial responses in those receiving placebo ( P less than 0.0001 , rank-sum test ) . At a dosage of 1.6 g per day , the response was twice as good as with placebo , but the difference did not reach statistical significance ( P = 0.51 ) . Age , sex , duration of disease , duration of active symptoms , or extent of disease did not affect the clinical outcome . We conclude that oral 5-ASA administered in a dosage of 4.8 g per day is effective therapy , at least in the short term , for mildly to moderately active ulcerative colitis
The evidence supports the WPAI as having test-retest reliability ( reproducibility ) over time ; convergent validity , as indicated by moderate correlations with measures of quality of life and moderate-to-strong correlations with measures of disease activity ; known-groups validity , as indicated by differences in WPAI scores between patients with active and inactive disease ; ability ( sensitivity ) to detect change , as indicated by substantial improvement in scores for patients who achieve remission , accompanied by substantial worsening of scores for patients who relapse ; and , responsiveness to treatment , with improvements in scores following treatments that reduce disease activity .
Patients with ulcerative colitis , a type of inflammatory bowel disease , report negative impacts of disease symptoms on work-related outcomes , including absenteeism and presenteeism .
As a way to better underst and the impact of this disease and its treatment on work-related outcomes , the current review examines the use of the Work Productivity and Activity Impairment Question naire ( WPAI ) , a patient-reported outcomes measure of absenteeism , presenteeism , and impairment in other activities , in studies of patients with ulcerative colitis .
This review assesses the measurement properties of the WPAI in this patient population : its reliability , construct validity , ability to detect change , and responsiveness to effective treatments .