Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults
Abstract Aims /hypothesisEpidemiological research indicates that long-chain n-3 polyunsaturated fatty acids ( LC n-3 PUFA ) improve insulin resistance . The aim of this study was to investigate the effects of seafood consumption on insulin resistance in overweight participants during energy restriction . Methods In this 8 week dietary intervention , 324 participants ( 20–40 years , BMI 27.5–32.5 kg/m2 , from Icel and , Spain and Irel and ) were r and omised by computer to one of four energy-restricted diets ( −30E% ) of identical macronutrient composition but different LC n-3 PUFA content : control ( n = 80 ; no seafood ; single-blinded ) ; lean fish ( n = 80 ; 150 g cod , three times/week ) ; fatty fish ( n = 84 ; 150 g salmon , three times/week ) ; ( 4 ) fish oil ( n = 80 ; daily docosahexaenoic/eicosapentaenoic acid capsules , no other seafood ; single-blinded  ) . Fasting glucose , insulin , adiponectin , plasma triacylglycerol and fatty acids in erythrocyte membrane were measured at baseline and endpoint . Insulin resistance was calculated using the homeostasis model assessment of insulin resistance ( HOMA-IR ) . Linear models with fixed effects and covariates were used to investigate the effects of seafood consumption on fasting insulin and HOMA-IR at endpoint in comparison with the control group . Results Of the participants , 278 ( 86 % ) completed the intervention .  Fish oil intake was a significant predictor of fasting insulin and insulin resistance after 8 weeks , and this finding remained significant even after including weight loss , triacylglycerol reduction , increased LC n-3 PUFA in membranes or adiponectin changes as covariates in the statistical analysis . Weight loss was also a significant predictor of improvements . Conclusions /interpretationLC n-3 PUFA consumption during energy reduction exerts positive effects on insulin resistance in young overweight individuals , independently from changes in body weight , triacylglycerol , erythrocyte membrane or adiponectin . Trial registration : Clinical Trials.gov NCT00315770 . Funding : The YOUNG study is part of the SEAFOODplus Integrated Project , which is funded by the EC through the 6th Framework Programme Contract No. FOOD-CT-2004 - 506359
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .