The present systematic review shows that , with the exception of laparoscopic surgery , objective evidence of the effect of individual components of ERAS protocol s in reducing the stress response following colorectal surgery is limited
Abstract Enhanced Recovery or Fast Track Recovery after Surgery protocol s ( ERAS ) have significantly changed perioperative care following colorectal surgery and are promoted as reducing the stress response to surgery .
Inflammatory response after laparoscopic and conventional colorectal resections – results of a prospective randomized trial
Abstract Background : Short-term benefits of laparoscopic relative to conventional colorectal resections have been demonstrated in r and omized controlled trials . It has been suggested that a diminished cytokine and acute-phase response may be responsible for these advantages . Methods : In a r and omized controlled trial , patients underwent laparoscopic ( n=30 ) or conventional ( n=30 ) resection of colorectal tumors .  Plasma levels of interleukin-1 receptor antagonist ( IL-1RA ) , interleukin-6 ( IL-6 ) , interleukin-10 ( IL-10 ) , and C-reactive protein ( CRP ) were analyzed repeatedly . Postoperative peak levels and area under the curve values were calculated and compared between groups using the Mann-Whitney U-test . Results : Patient characteristics , preoperative cytokine , and CRP plasma levels were not different between each group . Postoperative peak concentrations of IL-6 ( P=0.05 ) and CRP ( P<0.001 ) and the overall postoperative plasma concentrations of IL-6 ( P=0.03 ) and CRP ( P=0.002 ) were lower in the laparoscopic than in the conventional group . Peak and overall IL-1RA ( P=0.2 ; P=0.2 ) and IL-10 ( P=0.4 ; P=0.6 ) plasma concentrations , respectively , were not different between groups . Conclusions : IL-6 and CRP plasma levels were lower after laparoscopic than conventional colorectal resections . The less intense inflammatory response may be an indicator of the milder surgical trauma inflicted by laparoscopic than conventional colorectal resection
The present systematic review shows that , with the exception of laparoscopic surgery , objective evidence of the effect of individual components of ERAS protocol s in reducing the stress response following colorectal surgery is limited
Abstract Enhanced Recovery or Fast Track Recovery after Surgery protocol s ( ERAS ) have significantly changed perioperative care following colorectal surgery and are promoted as reducing the stress response to surgery .