In general , studies suggest that root canal sealers elicit mild to severe toxic effects and that several factors may influence biocompatibility , e.g. , material setting condition and time , material concentration , and type of exposure .
4 ) Conclusions : The available evidence shows that root canal sealers exhibit variable toxic potential at the cellular and tissue level .
However , the method ological heterogeneity among studies included in this systematic review and the somewhat conflicting results do not allow a conclusion on which type of sealer presents higher biocompatibility .
( 1 ) Aim : To perform a systematic review of the literature on the biocompatibility of  root canal sealers  that encompasses the various types of sealers that are commercially available as well as both in vitro and in vivo evidence . (
Comparing subcutaneous tissue responses to freshly mixed and set root canal sealers
INTRODUCTION : The purpose of this study was to compare the subcutaneous tissue responses of freshly mixed or set endodontic root canal sealers ( i.e. RoekoSeal , AH26 , AH Plus ) in Wistar Albino rats . MATERIAL S AND METHODS : Seventy-two male albino rats weighing 200 - 250 g were used . The animals were r and omly divided into six groups of 12 rats each . Root canal sealers were implanted in subcutaneous tissue in both freshly mixed and set conditions . The animals were sacrificed after 7 , 14 , and , 60 days . After histological preparation and Hematoxylin and Eosin ( H&E ) staining , the specimens were evaluated for capsule thickness , severity and extent of inflammation , and necrosis . Results were statistically analyzed using Multivariate ANOVA test . RESULTS : Differences between set and freshly mixed root canal sealers were significant ( P=0.014 ) , but not significant between test material s and controls , except for capsule thickness and extent of inflammation between control and AH26 ( P=0.019 and P=0.006 respectively ) . The interaction between the type of material and setting condition was significant for capsule thickness and severity of inflammation in AH26 specimens at 14 and 60 days ( P=0.001 ) . CONCLUSION : Based on the results of this study assessing the biocompatibility , both set and freshly mixed states can be used . [ Iranian Endodontic Journal 2009;4(4):152 - 7
In general , studies suggest that root canal sealers elicit mild to severe toxic effects and that several factors may influence biocompatibility , e.g. , material setting condition and time , material concentration , and type of exposure .
4 ) Conclusions : The available evidence shows that root canal sealers exhibit variable toxic potential at the cellular and tissue level .
However , the method ological heterogeneity among studies included in this systematic review and the somewhat conflicting results do not allow a conclusion on which type of sealer presents higher biocompatibility .
( 1 ) Aim : To perform a systematic review of the literature on the biocompatibility of  root canal sealers  that encompasses the various types of sealers that are commercially available as well as both in vitro and in vivo evidence . (