We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .
Furosemide in essential hypertension. A statistical analysis of three double-blind studies.
The antihypertensive action of furosemide was evaluated in double-blind studies conducted in three different hospital clinics , by investigators following an identical protocol . The pressure lowering effect of furosemide was compared with that of a placebo in a r and omized cross-over study . Both systolic and diastolic pressures were lowered significantly from pretreatment levels in over 50 % of patients . No clinical ly important side effects attributable to furosemide were encountered in this study . Hyperuricemia was encountered in 31 of 44 patients . No significant disturbances of electrolyte balance were noted . Statistical analysis of the pooled data supported the conclusion that furosemide exerts an antihypertensive effect similar to that of other widely used sulfonamide diuretics , and therefore appears to be an effective agent for the treatment of mild to moderate hypertension
We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .