Current evidence also suggests the efficacy of  dimethyl sulfoxide and amitryptyline therapy .
Hydroxyzine , intravesical bacille Calmette-Guérin  , and  resiniferatoxin therapy  failed to demonstrate efficacy , but evidence was inconclusive owing to method ological limitations .
Pentosan polysulfate may be modestly beneficial for symptoms of PBS/IC .
There is insufficient evidence for other pharmacologic treatments .
BACKGROUND More than 180 different types of therapy have been used in the treatment and management of  painful bladder syndrome/interstitial cystitis ( PBS/IC ) , yet evidence from clinical trials remains inconclusive .
This study aim ed to evaluate the efficacy of pharmacologic approaches to PBS/IC , to quantify the effect size from r and omized controlled trials , and to begin to inform a clinical consensus of treatment efficacy for PBS/IC .
Successful therapy of interstitial cystitis with pentosanpolysulfate.
Sodium pentosanpolysulfate ( Elmiron ) is a synthetic , sulfated polysaccharide available in an oral form that is excreted into the urine . This drug was used in a double-blind fashion to evaluate its efficacy in the management of symptoms of interstitial cystitis . A dose of 100 mg . 3 times daily was used for a minimum of 4 months and was continued for longer than 18 months in some individuals . A total of 62 patients was evaluated from 2 different medical centers . Subjective improvements were greater in all parameters when the drug was compared to placebo therapy , with significant improvement in pain , urgency , frequency and nocturia . Objective improvement in average voided volumes was greater with the drug than with placebo ( p equals 0.009 ) . No significant difference was found between drug and placebo groups in the average number of daily voiding episodes
Current evidence also suggests the efficacy of  dimethyl sulfoxide and amitryptyline therapy .
Hydroxyzine , intravesical bacille Calmette-Guérin  , and  resiniferatoxin therapy  failed to demonstrate efficacy , but evidence was inconclusive owing to method ological limitations .
Pentosan polysulfate may be modestly beneficial for symptoms of PBS/IC .
There is insufficient evidence for other pharmacologic treatments .
BACKGROUND More than 180 different types of therapy have been used in the treatment and management of  painful bladder syndrome/interstitial cystitis ( PBS/IC ) , yet evidence from clinical trials remains inconclusive .
This study aim ed to evaluate the efficacy of pharmacologic approaches to PBS/IC , to quantify the effect size from r and omized controlled trials , and to begin to inform a clinical consensus of treatment efficacy for PBS/IC .