Azapirones may be less effective than benzodiazepines and we were unable to conclude if azapirones were superior to antidepressants , kava kava or psychotherapy .
Azapirones appeared to be well tolerated .
Azapirones appeared to be useful in the treatment of GAD , particularly for those participants who had not been on a benzodiazepine .
Azapirones may not be superior to benzodiazepines and do not appear as acceptable as benzodiazepines .
Side effects appeared mild and non serious in the azapirone treated group .
Longer term studies are needed to show that azapirones are effective in treating GAD , which is a chronic long-term illness
BACKGROUND Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from generalized anxiety disorder ( GAD ) .
However , several studies have shown conflicting results .
Whether azapirones are useful as first line treatment in general anxiety disorders still needs to be answered .
OBJECTIVES To assess the efficacy and the acceptability of azapirones for the treatment of GAD .
A placebo‐controlled double‐blind multicenter trial of two doses of ipsapirone versus diazepam in generalized anxiety disorder
Ipsapirone is a partial 5-HT1A , agonist which appears promising for the pharmacologic treatment of anxiety . In this four-week , double-blind , 19-center study , 249 out patients with generalized anxiety disorder were r and omized to one of four treatments : ipsapirone , 5 or 10 mg t.i.d . , diazepam 5 mg t.i.d . , or placebo . Both active treatments were significantly superior to placebo in reducing anxiety symptoms , although response to ipsapirone was not significant until week 2 while diazepam had a more rapid onset . Five mg t.i.d . was the optimal ipsapirone dose . At 10 mg t.i.d . adverse experiences prompted more patients to discontinue treatment . Adverse experiences that were reported significantly more often for ipsapirone than placebo included asthenia , nausea , dizziness , paresthesias and sweating . Sedation was the most common diazepam-related side effect . The results of this study when combined with others suggest that 5 mg t.i.d . of ipsapirone is an effective and well-tolerated anxiolytic without many of the risks of benzodiazepine therapy . Dosage escalation by patients is unlikely because of an increased risk of side effects
Azapirones may be less effective than benzodiazepines and we were unable to conclude if azapirones were superior to antidepressants , kava kava or psychotherapy .
Azapirones appeared to be well tolerated .
Azapirones appeared to be useful in the treatment of GAD , particularly for those participants who had not been on a benzodiazepine .
Azapirones may not be superior to benzodiazepines and do not appear as acceptable as benzodiazepines .
Side effects appeared mild and non serious in the azapirone treated group .
Longer term studies are needed to show that azapirones are effective in treating GAD , which is a chronic long-term illness
BACKGROUND Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from generalized anxiety disorder ( GAD ) .
However , several studies have shown conflicting results .
Whether azapirones are useful as first line treatment in general anxiety disorders still needs to be answered .
OBJECTIVES To assess the efficacy and the acceptability of azapirones for the treatment of GAD .