Conclusions No conclusive recommendations were possible due to wide variation in study quality , method ologies and outcome measures .
A synthesis of available literature suggests that treatments containing urea as a primary active ingredient have been the most research ed .
Background Xerosis , literally dryness of the skin , of the foot is a common condition encountered clinical ly , which can lead to discomfort and predisposition to infection .
Currently , there are no evidence -based recommendations on which moisturiser formulations best alleviate xerotic symptoms .
The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis , by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population .
A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis.
Xerotic skin is a pattern of reaction to a variety of disorders that have abnormalities of desquamation in common . This double-blind , r and omized clinical trial investigated the effect of Lactinol ( Pedinol Pharmaceuticals , Farmingdale , New York ) versus Lac-Hydrin 12 % ( Bristol-Myers Squibb , Princeton , New Jersey ) lotion in mild to moderate foot xerosis .  Clinical assessment of xerosis was performed at baseline visit , and the design ated sites were evaluated at 2 and 4 weeks after treatment began . Of the 53 patients enrolled , 18 were excluded from analysis . Although both treatment groups had significantly improved xerosis scores after 2 and 4 weeks of treatment , no statistically significant difference was observed . Of the 44 % of patients who did express a preference , 72 % preferred Lactinol , which may account for the 20 % increase in its overall use in the study
Conclusions No conclusive recommendations were possible due to wide variation in study quality , method ologies and outcome measures .
A synthesis of available literature suggests that treatments containing urea as a primary active ingredient have been the most research ed .
Background Xerosis , literally dryness of the skin , of the foot is a common condition encountered clinical ly , which can lead to discomfort and predisposition to infection .
Currently , there are no evidence -based recommendations on which moisturiser formulations best alleviate xerotic symptoms .
The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis , by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population .