Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: should we consider monitoring central blood pressure?
BACKGROUND Data concerning blood pressure changes , acutely induced by caffeine consumption , are conflicting . Furthermore , limited data exist regarding central hemodynamic response to caffeine ingestion by healthy young subjects . We investigated the acute effect of coffee ( 80 mg of caffeine ) and decaffeinated coffee on peripheral and central hemodynamics , as well as on wave reflections . SUBJECTS For this purpose , 16 healthy volunteers ( eight females and eight males , mean age 29+/-3.2 years ) were investigated . METHODS Repeated measurements were performed at baseline and 30 , 60 , 90 and 120 min after oral administration of each beverage in a double-blind crossover design . Aortic blood pressures , augmentation index ( AI ) and pressure ( AP ) and timing of reflected waves were evaluated by using applanation tonometry and pulse wave analysis . RESULTS Regular coffee increased central systolic ( SBP ) and diastolic pressure ( DBP ) from 96.2+/-9.9 to 101.1+/-10.1 mmHg , p=0.011 and from 72.6+/-9.4 to 76.5+/-9.0 mmHg , p=0.027 , respectively , but no change was observed following consumption of decaffeinated coffee .  Peripheral systolic blood pressure did not change significantly after the administration of either coffee . Augmentation index increased significantly following regular coffee consumption . The change in AI was significantly higher following regular compared to decaffeinated coffee consumption as shown by analysis of variance ( ANOVA ) for repeated measures ( p=0.001 ) . CONCLUSIONS These caffeine effects reveal an unfavourable effect on wave reflections and therefore on left ventricular ( LV ) pulsatile afterload . It also revealed a significant acute effect of caffeine consumption on central hemodynamics which is not observed at peripheral pressures
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .