Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .
Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery.
Excess adiposity is associated with low- grade inflammation and decreased iron status . Iron depletion in obesity is thought to be mediated by an inflammation-induced increase in the body 's main regulator of iron homeostasis , hepcidin . Elevated hepcidin can result in iron depletion as it prevents the release of dietary iron absorbed into the enterocytes , limiting replenishment of body iron losses . Weight reduction is associated with decreased inflammation ; however , the impact of reduced inflammation on iron status and systemic hepcidin in obese individuals remains unknown . We determined prospect ively the impact of weight loss on iron status parameters , serum hepcidin , inflammation , and dietary iron  in 20 obese premenopausal females 6 months after restrictive bariatric surgery .  At baseline , the presence of iron depletion was high with 45 % of the women having serum transferrin receptor ( sTfR ) > 28.1 nmol/l . Differences between baseline and 6 months after surgery for BMI ( 47.56 vs. 39.55 kg/m(2 ) ; P < 0.0001 ) , C-reactive protein ( CRP ) ( 10.83 vs. 5.71 mg/l ; P < 0.0001 ) , sTfR ( 29.97 vs. 23.08 nmol/l ; P = 0.001 ) , and serum hepcidin ( 111.25 vs. 31.35 ng/ml ; P < 0.0001 ) were significantly lower , whereas hemoglobin ( Hb ) ( 12.10 vs. 13.30 g/dl ; P < 0.0001 ) and hematocrit ( Hct ) ( 36.58 vs. 38.78 % ; P = 0.001 ) were significantly higher . Ferritin and transferrin saturation ( Tsat ) showed minimal improvement at follow-up . At baseline , hepcidin was not correlated with sTfR ( r = 0.02 ) ; however , at follow-up , significant correlations were found ( r = -0.58 ) . Change in interleukin-6 ( IL-6 ) from baseline was marginally associated with decreased log serum hepcidin ( Δ IL-6 : β = -0.22 ; P = 0.15 ) , whereas change in BMI or weight was not . No significant difference in dietary iron was noted after surgery . Weight loss in obese premenopausal women is associated with reduced serum hepcidin and inflammation . Reduction in inflammation and hepcidin likely allow for enhanced dietary iron absorption result ing in an improved functional iron profile
Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .