Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial.
BACKGROUND Coffee , a source of antioxidants , has controversial effects on cardiovascular health . OBJECTIVE We evaluated the bioavailability of chlorogenic acids ( CGAs ) in 2 coffees and the effects of their consumption on the plasma antioxidant capacity ( AC ) , the serum lipid profile , and the vascular function in healthy adults . METHODS Thirty-eight men and 37 women with a mean ± SD age of 38.5 ± 9 y and body mass index of 24.1 ± 2.6 kg/m(2 ) were r and omly assigned to 3 groups : a control group that did not consume coffee or a placebo and 2 groups that consumed 400 mL coffee/d for 8 wk containing a medium ( MCCGA ; 420 mg ) or high ( HCCGA ; 780 mg ) CGA content . Both were low in diterpenes ( 0.83 mg/d ) and caffeine ( 193 mg/d ) . Plasma caffeic and ferulic acid concentrations were measured by GC , and the plasma AC was evaluated with use of the ferric-reducing antioxidant power method . The serum lipid profile , nitric oxide ( NO ) plasma metabolites , vascular endothelial function ( flow-mediated dilation ; FMD ) , and blood pressure ( BP ) were evaluated . RESULTS After coffee consumption ( 1 h and 8 wk ) , caffeic and ferulic acid concentrations increased in the coffee-drinking groups , although the values of the 2 groups were significantly different ( P < 0.001 ) ; caffeic and ferulic acid concentrations were undetectable in the control group . At 1 h after consumption , the plasma AC in the control group was significantly lower than the baseline value ( -2 % ) and significantly increased in the MCCGA ( 6 % ) and HCCGA ( 5 % ) groups ( P < 0.05 ) . After 8 wk , no significant differences in the lipid , FMD , BP , or NO plasma metabolite values were observed between the groups . CONCLUSIONS Both coffees , which contained CGAs and were low in diterpenes and caffeine , provided bioavailable CGAs and had a positive acute effect on the plasma AC in healthy adults and no effect on blood lipids or vascular function . The group that did not drink coffee showed no improvement in serum lipid profile , FMD , BP , or NO plasma metabolites . This trial was registered at registroclinico.sld.cu as RPCEC00000168
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .