For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .
Efficacy and safety of oral sildenafil (Viagra) in men with erectile dysfunction caused by spinal cord injury
Objective : To evaluate the efficacy and safety of 50-mg doses of sildenafil during a 28-day period in patients with erectile dysfunction caused by spinal cord injury ( cord level range , T6 through L5 ) . Background : Sildenafil is an orally active , potent , and selective inhibitor of phosphodiesterase type 5 , an important regulator of cyclic guanosine monophosphate in the human corpus cavernosum . Methods : To be included in this double-blind , placebo-controlled study , all patients had to be able to achieve at least a partial reflexogenic erectile response to penile vibratory stimulation . The study utilized a single triangular sequential trial design . A total of 27 patients were r and omized to receive 50 mg of sildenafil or placebo , taken orally as required ( not more than once daily ) approximately 1 hour before sexual activity . Results : After 28 days of treatment , nine of 12 patients ( 75 % ) on sildenafil and one of 14 patients ( 7 % ) on placebo reported that treatment had improved their erections ( p = 0.0043 ) . Furthermore , eight of 12 patients ( 67 % ) on sildenafil and two of 13 patients ( 15 % ) on placebo indicated that they wished to continue treatment ( p = 0.018 ) . A significant improvement in satisfaction with their sex life was reported by patients taking sildenafil ( p = 0.012 ) . No patients discontinued treatment due to adverse events . Conclusion : Oral sildenafil , taken as required ( not more than once daily ) , significantly improves the quality of erections and satisfaction with sex life in men with erectile dysfunction caused by a spinal cord injury between T6 and L5
For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .