There is no RCT evidence demonstrating that antihypertensive drugs reduce mortality or morbidity in patients with hypertensive emergencies .
Furthermore , there is insufficient RCT evidence to determine which drug or drug class is most effective in reducing mortality and morbidity .
There were some minor differences in the degree of blood pressure lowering when one class of antihypertensive drug is compared to another .
However , the clinical significance is unknown .
Hypertensive emergencies occur when high blood pressure is associated with the presence of acute end-organ damage , such as hypertensive encephalopathy .
There is controversy as to when and which antihypertensive drugs to use in these situations .
A comparison of intravenous nicardipine and sodium nitroprusside in the immediate treatment of severe hypertension.
The primary objective of this study was to compare the antihypertensive efficacy and safety of intravenously administered nicardipine with that of intravenous nitroprusside ( SNP ) in patients with severe hypertension . The study was conducted in 121 patients with severe hypertension ( diastolic blood pressure [ BP ] > 120 mm Hg , or systolic BP > 200 mm Hg ) . Patients were r and omized to receive intravenous nicardipine or SNP .  Drugs were administered according to a predetermined dosing schedule for a 10 to 12 h period . Sixty-one patients were r and omized to intravenous nicardipine and 60 to SNP . Pretreatment BP values for the nicardipine and SNP groups were 217/128 mm Hg and 219/128 mm Hg , respectively . Therapeutic response ( diastolic BP < 100 mm Hg , or a decrease of > 15 mm Hg ; systolic BP < 180 mm Hg , or a decrease of > 20 mm Hg ) was achieved in 98 % ( 60/61 ) of patients treated with nicardipine and 93 % ( 56/60 ) of patients treated with SNP . The mean decreases in systolic and diastolic BP were 61 mm Hg and 40 mm Hg after 4 h of nicardipine , and 59 mm Hg and 38 mm Hg after 4 h of SNP . The mean increases in heart rate also were similar in both groups ( nicardipine , 12 beats/min ; SNP 10 beats/min ) . The mean numbers of dose adjustments per hour required to maintain the BP reductions were lower ( P < .01 ) in the nicardipine-treated patients ( 0.5 + /- 0.1 times per hour ) than in the SNP-treated patients ( 1.5 + /- 0.2 times per hour ) . ( ABSTRACT TRUNCATED AT 250 WORDS
There is no RCT evidence demonstrating that antihypertensive drugs reduce mortality or morbidity in patients with hypertensive emergencies .
Furthermore , there is insufficient RCT evidence to determine which drug or drug class is most effective in reducing mortality and morbidity .
There were some minor differences in the degree of blood pressure lowering when one class of antihypertensive drug is compared to another .
However , the clinical significance is unknown .
Hypertensive emergencies occur when high blood pressure is associated with the presence of acute end-organ damage , such as hypertensive encephalopathy .
There is controversy as to when and which antihypertensive drugs to use in these situations .