Subgroup analyses showed that using whole flaxseed in doses ≥30 g d-1 , longer-term interventions ( ≥12 weeks ) and studies including participants with higher BMI ( ≥ 27 kg m-2 ) had positive effects on body composition  .
Whole flaxseed is a good choice for weight management particularly for weight reduction in overweight and obese participants
Flaxseed consumption may be inversely associated with obesity ; however , findings of available r and omized controlled trials ( RCTs ) are conflicting .
The present study aim ed to systematic ally review and analyse RCTs assessing the effects of flaxseed consumption on body weight and body composition .
Flaxseed Supplementation (Not Dietary Fat Restriction) Reduces Prostate Cancer Proliferation Rates in Men Presurgery
Background : Prostate cancer affects one of six men during their lifetime . Dietary factors are postulated to influence the development and progression of prostate cancer . Low-fat diets and flaxseed supplementation may offer potentially protective strategies . Methods : We undertook a multisite , r and omized controlled trial to test the effects of low-fat and /or flaxseed-supplemented diets on the biology of the prostate and other biomarkers . Prostate cancer patients ( n = 161 ) scheduled at least 21 days before prostatectomy were r and omly assigned to one of the following arms : ( a ) control ( usual diet ) , ( b ) flaxseed-supplemented diet ( 30 g/d ) , ( c ) low-fat diet ( < 20 % total energy ) , or ( d ) flaxseed-supplemented , low-fat diet . Blood was drawn at baseline and before surgery and analyzed for prostate-specific antigen , sex hormone-binding globulin , testosterone , insulin-like growth factor-I and binding protein-3 , C-reactive protein , and total and low-density lipoprotein cholesterol . Tumors were assessed for proliferation ( Ki-67 , the primary endpoint ) and apoptosis . Results : Men were on protocol an average of 30 days . Proliferation rates were significantly lower ( P < 0.002 ) among men assigned to the flaxseed arms . Median Ki-67-positive cells/total nuclei ratios ( ×100 ) were 1.66 ( flaxseed-supplemented diet ) and 1.50 ( flaxseed-supplemented , low-fat diet ) versus 3.23 ( control ) and 2.56 ( low-fat diet ) . No differences were observed between arms with regard to side effects , apoptosis , and most serologic endpoints ; however , men on low-fat diets experienced significant decreases in serum cholesterol ( P = 0.048 ) . Conclusions : Findings suggest that flaxseed is safe and associated with biological alterations that may be protective for prostate cancer . Data also further support low-fat diets to manage serum cholesterol . ( Cancer Epidemiol Biomarkers Prev 2008;17(12):3577–87
Subgroup analyses showed that using whole flaxseed in doses ≥30 g d-1 , longer-term interventions ( ≥12 weeks ) and studies including participants with higher BMI ( ≥ 27 kg m-2 ) had positive effects on body composition  .
Whole flaxseed is a good choice for weight management particularly for weight reduction in overweight and obese participants
Flaxseed consumption may be inversely associated with obesity ; however , findings of available r and omized controlled trials ( RCTs ) are conflicting .
The present study aim ed to systematic ally review and analyse RCTs assessing the effects of flaxseed consumption on body weight and body composition .