Initial combination therapy with DPP-IV inhibitors more effectively reduced MAGE than stepwise add-on therapies ( p = 0.006 ) , although no differences in MAGE were found based on HbA1c values .
These findings indicate that DPP-IV inhibitors are promising alternatives for reducing GV in type 2 diabetes patients .
Glycemic variability ( GV ) has been an emerging target for preventing complications related to type 2 diabetes .
For reducing GV , DPP-IV inhibitors have shown effectiveness compared to other oral anti-hyperglycemic drugs ( OADs ) , but systematic evaluation has yet to be existed .
Effect of gemigliptin on glycaemic variability in patients with type 2 diabetes (STABLE study)
The aim of this study was to evaluate the effect of gemigliptin vs sitagliptin or glimepiride as initial combination therapy with metformin on glycaemic variability and to assess the correlation between glycaemic variability reduction and the dipeptidyl peptidase‐4 ( DPP‐4 ) inhibition in patients with type 2 diabetes . This multicentre , r and omized , active‐controlled , open‐label exploratory study included 69 patients with HbA1c > 7.5 % . Subjects were r and omized to receive gemigliptin 50 mg ( n = 24 ) , sitagliptin 100 mg ( n = 23 ) or glimepiride 2 mg ( n = 22 ) for 12 weeks . After 12 weeks , the change in mean amplitude of glycaemic excursion ( MAGE ) compared with baseline was significantly lower in the DPP‐4 inhibitor groups compared with that in patients who received glimepiride . Furthermore , the st and ard deviation ( SD ) of glucose was significantly lower in patients who received gemigliptin than that in patients who received sitagliptin or glimepiride . The DPP‐4 inhibition was significantly correlated with changes in MAGE and SD of glucose . In conclusion , gemigliptin and sitagliptin were more effective than glimepiride in reducing glycaemic variability as initial combination therapy with metformin in patients with type 2 diabetes , and the DPP‐4 inhibition was associated with a reduction in glycaemic variability
Initial combination therapy with DPP-IV inhibitors more effectively reduced MAGE than stepwise add-on therapies ( p = 0.006 ) , although no differences in MAGE were found based on HbA1c values .
These findings indicate that DPP-IV inhibitors are promising alternatives for reducing GV in type 2 diabetes patients .
Glycemic variability ( GV ) has been an emerging target for preventing complications related to type 2 diabetes .
For reducing GV , DPP-IV inhibitors have shown effectiveness compared to other oral anti-hyperglycemic drugs ( OADs ) , but systematic evaluation has yet to be existed .