Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .
Bariatric Surgery can Reduce Albuminuria in Patients with Severe Obesity and Normal Kidney Function by Reducing Systemic Inflammation
Background Obesity causes renal problems including albuminuria . Bariatric surgery ( BS ) improves albuminuria . We investigated whether albuminuria is reduced by weight loss per se or by improved systemic inflammation induced by weight loss after BS . Methods Patients older than 18 years who received BS in Soonchunhyang University Hospital from 01 January 2011 to 31 December 2011 were included . Other inclusion criteria included body mass index ( BMI ) ≥ 30 kg/m2 , creatinine level ≤ 1.0 mg/dL , and no overt proteinuria ( trace amount or undetectable by dipstick ) . The patients were followed at 1 and 6 months after BS . Results Forty-three patients were analyzed . Three patients were men , 10 patients had diabetes , and 12 patients had hypertension . All patients had normal renal function ( creatinine ≤ 1.0 mg/dL ) , and estimated glomerular filtration rate was 115.7 ± 16.5 mL/min/1.73 m2 . There were significant reductions in body weight , BMI , high-sensitivity C-reactive protein ( hs-CRP ) , and urine albumin-to-creatinine ratio ( ACR ) . There were positive correlations between delta hs-CRP and delta body weight ( r = 0.349 , p = 0.043 ) or delta body mass index ( BMI , r = 0.362 , p = 0.035 ) ; between hs-CRP and body weight ( r = 0.374 , p = 0.001 ) , BMI ( r = 0.431 , p < 0.001 ) . Multivariate analysis using a linear mixed model demonstrated that hs-CRP ( β = 0.5364 , p = 0.026 ) was an independent risk factor affecting ACR . Conclusions Our study suggests that BS can reduce albuminuria in patients with severe obesity and normal kidney function by reducing systemic inflammation
Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .