Changes in both systolic and diastolic BP were greater in participants with higher baseline BP or BMI .
The DASH diet improved cardiovascular risk factors and appeared to have greater beneficial effects in subjects with an increased cardiometabolic risk .
The DASH diet is an effective nutritional strategy to prevent CVD
The Dietary Approach to Stop Hypertension ( DASH ) is recommended to lower blood pressure ( BP ) , but its effects on cardiometabolic biomarkers are unclear .
A systematic review and meta- analysis of r and omised controlled trials ( RCT ) was conducted to determine the effects of the DASH diet on cardiovascular risk factors .
The DASH diet enhances the blood pressure response to losartan in hypertensive patients.
BACKGROUND The Dietary Approaches to Stop Hypertension ( DASH ) diet , which emphasizes fruits , vegetables , and low fat dairy products , significantly lowers blood pressure ( BP ) . We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication , losartan , in participants with essential hypertension . METHODS A total of 55 hypertensive participants were r and omly assigned to 8 weeks of controlled feeding with either a control diet or the DASH diet . Within each diet arm , participants received losartan 50 mg daily or placebo for 4 weeks each , in double blind , r and omized , cross-over fashion . Twenty-four-hour ambulatory BP ( ABP ) was measured at the end of a 2-week run-in period ( baseline ) and after each 4-week intervention period . RESULTS There was no significant change in ABP during the placebo period on the control diet ( n = 28 ) ( -2.3 + /- 1.5/-1.6 + /- 1.0 mm Hg ) , but there was a significant reduction in systolic ABP ( -5.3 + /- 1.5 mm Hg , P < .05 ) and no change in DBP ( -2.5 + /- 1.0 mm Hg ) on the DASH diet ( n = 27 ) . Losartan significantly reduced ABP on the control diet ( -6.7 + /- 1.5/-3.7 + /- 1.0 mm Hg , P < .05 ) and to a greater extent on the DASH diet ( -11.7 + /- 1.5/-6.9 + /- 1.0 mm Hg , P < .05 versus basal and control diet ) particularly in African Americans . On the DASH diet , DeltaSBP on losartan was inversely related to basal plasma renin activity ( n = -0.53 , P = .004 ) . CONCLUSIONS The DASH diet enhances the ABP response to losartan in essential hypertension . This effect is particularly marked in African Americans
Changes in both systolic and diastolic BP were greater in participants with higher baseline BP or BMI .
The DASH diet improved cardiovascular risk factors and appeared to have greater beneficial effects in subjects with an increased cardiometabolic risk .
The DASH diet is an effective nutritional strategy to prevent CVD
The Dietary Approach to Stop Hypertension ( DASH ) is recommended to lower blood pressure ( BP ) , but its effects on cardiometabolic biomarkers are unclear .
A systematic review and meta- analysis of r and omised controlled trials ( RCT ) was conducted to determine the effects of the DASH diet on cardiovascular risk factors .