Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .
Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: a prospective randomized, double blinded, controlled trial.
Use of silicone derivative and onion extract had been reported in the prevention of hypertrophic scarring . Our experience showed the preventive use of silicone derivative plus onion extract gel on hypertrophic scars after median sternotomy . In a r and omized , double blinded , placebo-controlled study , 60 patients after median sternotomy incisions were separated into two groups . All patients were treated either with silicone derivative plus onion extract gel ( Cybele ( ® ) scagel ) or placebo gel twice daily for a total treatment period of 12 weeks . During each visit , pain and itching scores were grade d by the patients and scar characteristics were observed by surgeons using the Vancouver scar scale . Pain and itch score values from patients ' who applied silicone derivative plus onion extract gel was less than another group ( P < 0·05 ) . Pigmentation was significantly different between two groups ( P < 0·05 ) and the reduction of scores on vascularity , pliability , height in treated group was not superior to the untreated group . No adverse events were reported by any of the patients . A silicone derivative plus onion extract gel is safe and effective for the preventing the hypertrophic scarring after median sternotomy
Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .