Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .
Does Lipoic Acid Consumption Affect the Cytokine Profile in Multiple Sclerosis Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
Background : A limited amount of data exists regarding the effect of lipoic acid ( LA ) , an oral antioxidant supplement , on cytokine profiles among multiple sclerosis ( MS ) patients . Objective : We aim ed to assess the effect of daily consumption of LA on the cytokine profiles in MS patients . Methods : In this double-blind , placebo-controlled , r and omized clinical trial , 52 relapsing-remitting MS patients with an age range of 18 - 50 years were recruited into 2 groups : LA consumption ( 1,200 mg/day ) or placebo . Patients followed their prescribed supplements for 12 weeks  . Fasting blood sample s for cytokine profile measurement were collected at baseline and after the intervention . Anthropometric parameters were measured based on the st and ard guidelines . Results : INF-γ , ICAM-1 , TGF-β and IL-4 were significantly reduced in the LA group compared to the placebo group [ ( INF-γ : 0.82 ± 0.2 vs. 0.2 ± 0.2 pg/ml , p < 0.0001 ) , ( ICAM-1 : 20.2 ± 9.4 vs. 8 ± 10 ng/ml , p = 0.0001 ) , ( TGF-β : 103.1 ± 20.2 vs. 54.9 ± 26 ng/ml , p < 0.0001 ) and ( IL-4 : 0.1 ± 0.1 vs. 1.02 ± 1.7 ng/ml , p = 0.0112 ) ] . No significant changes in TNF-α , IL-6 , EDSS and MMP-9 were found between the LA and placebo groups ( p = 0.6 , p = 0.8 , p = 0.09 and p = 0.8 , respectively ) . Conclusion : The results suggested that consumption of 1,200 mg LA per day beneficially affects several inflammatory cytokines including INF-γ , ICAM-1 TGF-β and IL-4 . Further investigations are needed to verify the beneficial role of LA on other cytokine profiles among MS patients
Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .