None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .
Insulin infusion improves neutrophil function in diabetic cardiac surgery patients.
UNLABELLED Diabetic patients are at increased risk of wound infection after major surgery , but the effect of perioperative glucose control on postoperative wound infection rates after surgery is uncertain . We tested the effect of an insulin infusion on perioperative neutrophil function in diabetic patients scheduled for coronary artery bypass surgery . Participants ( n = 26 ) were r and omly allocated to receive either aggressive insulin therapy ( AIT ) or st and ard insulin therapy ( SIT ) during surgery . Blood was drawn for neutrophil testing before surgery , 1 h after the completion of cardiopulmonary bypass , and on the first postoperative day . Neutrophil phagocytic activity decreased to 75 % of baseline activity in the AIT group and to 47 % of baseline activity in the SIT group ( P < 0.05 between groups ) . No important differences in neutrophil antibody-dependent cell cytotoxicity were found . This study documents a potentially beneficial effect of continuous insulin therapy in diabetic patients who require major surgery . IMPLICATION S A continuous insulin infusion and glucose control during surgery improves white cell function in diabetic patients and may increase resistance to infection after surgery
None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .