Results : We confirmed the importance of the 4 main factors influencing SC : ( 1 ) environmental factors , ( 2 ) genomic factors , ( 3 ) gene-environment interactions , and ( 4 ) evidence -based interventions .
The model demonstrates the complex network of factors influencing SC .
Background : Smoking behaviour is a major public health problem worldwide .
Several sources have confirmed the implication of genomic factors in smoking behaviour .
These factors interact both with environmental factors and interventions to develop a certain behaviour .
Objectives : Describing the environmental and genomic factors as well as the interventions influencing smoking cessation  ( SC ) and developing a working model incorporating the different factors influencing SC were our main objectives .
Association between nicotinic acetylcholine receptor single nucleotide polymorphisms and smoking cessation.
INTRODUCTION The α4β2 nicotinic receptor is of central importance in tobacco dependence , while the homomeric α7 receptor may also play a role . In this c and i date gene study , we examine the association between 8 single nucleotide polymorphisms ( SNPs ) in genes coding for nicotinic acetylcholine receptor subunits α4 ( rs1044396 , rs2273504 , rs2236196 , and rs2273502 ) , α7 ( rs2133965 and rs4779969 ) , and β2 ( rs2072660 and rs2072661 ) and smoking abstinence in a cohort of quitters enrolled in a clinical trial of behavioral support . METHODS Data were obtained from the " Patch in Practice " study , involving 925 smokers in the United Kingdom . All participants were given an 8-week course of 15 mg of transdermal nicotine replacement therapy and blood was taken for genotyping . RESULTS Logistic regression analyses assessed the association between each selected SNP and smoking abstinence at 4 , 12 , 26 , and 52 weeks . There were no statistically significant associations with smoking cessation success or nicotine intake assessed by plasma cotinine levels . However , rs2273502 was associated with a consistent ( though nonsignificant ) increase in the odds of abstinence . CONCLUSIONS There was no compelling evidence that these SNPs were associated with a reduced or higher chance of abstinence . However , rs2273502 may be worth investigating in future studies
Results : We confirmed the importance of the 4 main factors influencing SC : ( 1 ) environmental factors , ( 2 ) genomic factors , ( 3 ) gene-environment interactions , and ( 4 ) evidence -based interventions .
The model demonstrates the complex network of factors influencing SC .
Background : Smoking behaviour is a major public health problem worldwide .
Several sources have confirmed the implication of genomic factors in smoking behaviour .
These factors interact both with environmental factors and interventions to develop a certain behaviour .
Objectives : Describing the environmental and genomic factors as well as the interventions influencing smoking cessation  ( SC ) and developing a working model incorporating the different factors influencing SC were our main objectives .