Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .
Reduced serum cholesterol with dietary change using fat-modified and oat bran supplemented diets.
A low-fat , low-cholesterol diet and oat bran supplementation for treatment of hypercholesterolemia were studied for their effectiveness in lowering blood lipids and their impact on dietary intake . Seventy-one free-living men and women with hypercholesterolemia ( serum cholesterol greater than 75th percentile ) were r and omly assigned to one of the following four groups : low-fat , low-cholesterol diet ( LFLC ) ; low-fat , low-cholesterol diet plus 50 gm/day oat bran ( LFLC + OB ) ; 50 gm/day oat bran supplemented diet ( OB ) ; or 42.5 gm/day processed oat bran ( ready-to-eat cereal containing beta-glucan concentrated from oat bran ) ( POB ) . Subjects assigned to regimens OB and POB were requested to add the oat supplement without making additional changes in their diet . Serum cholesterol and high-density lipoprotein cholesterol analyses were performed at 4-week intervals , and diet records were assigned and analyzed . All groups experienced significant decreases in cholesterol from original levels ( p less than .05 ) . The average decrease in total serum cholesterol varied from 10 % to 17 % , with no significant differences among the four groups . High-density lipoprotein cholesterol concentrations decreased in all groups except group 4 , in which there was a slight increase ; however , no differences were found between groups . Energy , fat , and cholesterol intakes decreased in all groups , suggesting that displacement of higher fat foods from the diet may be one of the many mechanisms whereby oat supplements lower serum cholesterol . In addition , all groups reduced their intakes of calcium , copper , folic acid , and potassium from marginal levels at the beginning of the study . ( ABSTRACT TRUNCATED AT 250 WORDS
Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .