Conclusions Large r and omized controlled trials of at least 6 months duration with carbohydrate restriction appear superior in improving lipid markers when compared with low-fat diets .
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk .
Objective A systematic review and meta-analyses were conducted to compare the effects of very low , low , and moderate carbohydrate , higher fat diets versus high-carbohydrate , low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults .
Low HDL predicts differential blood pressure effects from two weight-loss approaches: a secondary analysis of blood pressure from a randomized, clinical weight-loss trial.
Examining predictors of blood-pressure ( BP ) response to weight-loss diets might provide insight into mechanisms and help guide clinical care . We examined whether certain baseline patient characteristics ( e.g. diet , medical history and laboratory tests ) predicted BP response to two weight-loss diet approaches that differ in macronutrient content . One hundred and forty-six overweight adult out patients were r and omized to either a low-carbohydrate diet ( N = 72 ) or orlistat plus a low-fat diet ( N = 74 ) for 48 weeks . Predictors of BP reduction were evaluated using a structured approach and r and om effects regression models . Participants were 56 % African-American , 72 % male and 53 ( ±10 ) years-old . Of the variables considered , low baseline high-density lipoprotein ( HDL ) predicted greater reduction in BP in those patients who received the low-carbohydrate diet ( p = 0.03 for systolic BP ; p = 0.03 for diastolic BP and p = 0.02 for mean arterial pressure ) . A low HDL level may identify patients who will have greater BP improvement on a low-carbohydrate diet
Conclusions Large r and omized controlled trials of at least 6 months duration with carbohydrate restriction appear superior in improving lipid markers when compared with low-fat diets .
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk .
Objective A systematic review and meta-analyses were conducted to compare the effects of very low , low , and moderate carbohydrate , higher fat diets versus high-carbohydrate , low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults .