The analysis revealed that desmopressin might significantly decrease the frequency of nocturnal voids , nocturnal urine volume and nocturnal diuresis , potentially result ing in an extended duration of the first sleep period and improved sleep quality .
The adverse effects of desmopressin were similar to those observed in the placebo group .
Conclusions Administered desmopressin was an effective and well-tolerated treatment for nocturia
Purpose The purpose of this analysis was to evaluate the efficacy and safety of desmopressin for the treatment of nocturia .
Desmopressin in the treatment of daytime urinary frequency in patients with multiple sclerosis
Twenty two patients with multiple sclerosis , complaining of frequency of day time micturition  , completed a double blind crossover trial of desmopressin ( DDAVP nasal spray ) versus placebo . There was a significant decrease in micturition frequency in the 6 hour post-treatment period from 3.1 voids after placebo to 2.4 voids and a significant reduction in urinary volume after desmopressin . Eighty per cent of patients preferred the active treatment phase . Mean 24 hour urinary volume did not differ between active and placebo treatments and patients did not complain of increased night time frequency . Transient symptoms of hyponatraemia occurred in one patient but these resolved within 48 hours of stopping desmopressin . There were otherwise no side effects and mean serum sodium concentrations of the group remained unchanged throughout the study . The clinical indications for prescribing daytime desmopressin are discussed and the importance of patient compliance stressed
The analysis revealed that desmopressin might significantly decrease the frequency of nocturnal voids , nocturnal urine volume and nocturnal diuresis , potentially result ing in an extended duration of the first sleep period and improved sleep quality .
The adverse effects of desmopressin were similar to those observed in the placebo group .
Conclusions Administered desmopressin was an effective and well-tolerated treatment for nocturia
Purpose The purpose of this analysis was to evaluate the efficacy and safety of desmopressin for the treatment of nocturia .