Subgroup analysis revealed that increasing dietary ALA tends to elevate CRP concentration  in healthy subjects .
However , the null effect of ALA supplementation on other inflammatory markers was not changed in various subgroups , indicating that the results are stable .
Meta-regression results revealed a negative relationship between the effect size on CRP and its baseline concentration .
No significant publication bias was observed for all inflammatory markers as suggested by funnel plot and Begg ’s test .
Conclusion Our meta- analysis did not find any beneficial effect of ALA supplementation  on reducing inflammatory markers including TNF , IL-6 , CRP , sICAM-1 , and sVCAM-1 .
However , in healthy subjects  , ALA supplementation might increase CRP concentration
Purpose The aim of the current meta- analysis was to investigate the effect of increasing dietary ALA intake on the blood concentration of inflammatory markers including tumor necrosis factor ( TNF ) , interleukin 6 ( IL-6 ) , C-reactive protein ( CRP ) , soluble intercellular adhesion molecule-1 ( sICAM-1 ) , and soluble vascular cell adhesion molecule-1 ( sVCAM-1 )  in adults .
Does grape seed oil improve inflammation and insulin resistance in overweight or obese women?
Abstract Grape seed oil ( GSO ) is reported to improve oxidative stress and lipid profile . However , the ameliorating effect of GSO on inflammation and insulin resistance has not being noticed so far . We aim ed to examine the effects of GSO consumption on inflammation and insulin resistance in overweight or obese females . The subjects ( n = 44 ) were r and omly assigned into intervention group as “ GSO ” ( consuming 15 % of energy from GSO ) and control group as sunflower oil “ SFO ” ( consuming 15 % of energy from SFO ) through a weight loss diet for 8 weeks . Anthropometric measurements , dietary recall and fasting serum glucose , insulin , high sensitive C-reactive protein ( hs-CRP ) and tumor necrosis factor-alpha ( TNF-α ) were assessed before and after the intervention . Homeostatic model assessment of insulin resistance ( HOMA-IR ) scores , hs-CRP and TNF-α decreased in the GSO group . The hs-CRP was lower in GSO than the SFO group ( p < 0.03 ) . GSO consumption seems to improve inflammatory condition and insulin resistance in overweight/obese women
Subgroup analysis revealed that increasing dietary ALA tends to elevate CRP concentration  in healthy subjects .
However , the null effect of ALA supplementation on other inflammatory markers was not changed in various subgroups , indicating that the results are stable .
Meta-regression results revealed a negative relationship between the effect size on CRP and its baseline concentration .
No significant publication bias was observed for all inflammatory markers as suggested by funnel plot and Begg ’s test .
Conclusion Our meta- analysis did not find any beneficial effect of ALA supplementation  on reducing inflammatory markers including TNF , IL-6 , CRP , sICAM-1 , and sVCAM-1 .
However , in healthy subjects  , ALA supplementation might increase CRP concentration
Purpose The aim of the current meta- analysis was to investigate the effect of increasing dietary ALA intake on the blood concentration of inflammatory markers including tumor necrosis factor ( TNF ) , interleukin 6 ( IL-6 ) , C-reactive protein ( CRP ) , soluble intercellular adhesion molecule-1 ( sICAM-1 ) , and soluble vascular cell adhesion molecule-1 ( sVCAM-1 )  in adults .