Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
The effect of monthly 50 000 IU or 100 000 IU vitamin D supplements on vitamin D status in premenopausal Middle Eastern women living in Auckland
Background / Objectives : Middle Eastern female immigrants are at an increased risk of vitamin D deficiency and their response to prescribed vitamin D dosages may not be adequate and affected by other factors . The objectives were to determine vitamin D deficiency and its determinants in Middle Eastern women living in Auckl and , New Zeal and ( Part-I ) , and to determine serum 25-hydroxyvitamin D ( serum-25(OH)D ) response to two prescribed vitamin D dosages ( Part-II ) in this population . Participants / Methods : Women aged ⩾20 ( n=43 ) participated in a cross-sectional pilot study during winter ( Part-I ) . In Part-II , women aged 20–50 years ( n=62 ) participated in a r and omised , double-blind placebo-controlled trial consuming monthly either 50 000 , 100 000 IU vitamin D3 or placebo for 6 months ( winter to summer ) . Results : All women in Part-I and 60 % women in Part-II had serum-25(OH)D<50 nmol/l . Serum-25(OH)D was higher in prescribed vitamin D users than nonusers ( P=0.001 ) and in Iranians than Arab women ( P=0.001 ; Part-I ) . Mean ( s.d . ) serum-25(OH)D increased in all groups ( time effect , P<0.001 ) and differed between groups ( time × dosage interaction , P<0.001 ; 50 000 IU : from 44.0±16.0 to 70.0±15.0 nmol/l ; 100 000 IU : 48.0±11.0 to 82.0±17.0 nmol/l ; placebo : 45.0±18.0 to 54.0±18.0 nmol/l ) . Only 32 % and 67 % achieved serum-25(OH)D⩾75 nmol/l with 50 000 and 100 000 IU/month , respectively . Predictors of 6-month change in serum-25(OH)D were dose ( B-coefficient±s.e . ; 14.1±2.4 , P<0.001 ) , baseline serum-25(OH)D ( −0.6±0.1 , P<0.001 ) and body fat percentage ( −0.7±0.3 , P=0.01 ) . Conclusions : Vitamin D deficiency/insufficiency is highly prevalent in this population . Monthly 100 000 IU vitamin D for 6 months is more effective than 50 000 IU in achieving serum-25(OH)D ⩾75 nmol/l ; however , a third of women still did not achieve these levels
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .