Widespread use of fluoroquinolone prophylaxis may be associated with an increase in resistant Escherichia coli strains , posing a potentially major health issue in the future .
INTRODUCTION Transrectal ultrasound-guided biopsies ( TRUS-gb ) are associated with both mild and serious complications .
Prophylactic antibiotics reduce the risk of septicaemia and mortality ; however , no international consensus exists on the timing and duration of antibiotics , including the optimal drug strategy .
We review ed the current evidence supporting use of prophylactic antibiotics and the risk of complications following prostate biopsies .
Single-dose oral ciprofloxacin versus placebo for prophylaxis during transrectal prostate biopsy.
OBJECTIVES To determine whether antimicrobial prophylaxis could prevent infections after transrectal needle biopsy of the prostate using automated biopsy devices . METHODS We conducted a prospect i ve , r and omized , double-blind , multicenter trial in which a total of 537 patients received either oral ciprofloxacin 500 mg or placebo before transrectal needle biopsy of the prostate . Repeated urine cultures and urinalysis were obtained at 2 to 6 days after biopsy and 9 to 15 days after biopsy . The primary determinant of efficacy was bacteriologic response ( bacteriuria [ more than 10(4 ) colony-forming units (CFU)/mL ] versus no bacteriuria ) at the 9- to 15-day follow-up evaluation . RESULTS Two hundred twenty-seven ( 84 % ) of 269 ciprofloxacin patients and 230 ( 86 % ) of 268 placebo patients were valid for efficacy analysis in which a mean of four biopsies was performed . Six ciprofloxacin-treated ( 3 % ) and 19 placebo-treated ( 8 % ) patients had bacteriuria ( more than 10(4 ) CFU/mL ) after the procedure ( P = 0.009 ) . Six ciprofloxacin recipients ( 3 % ) and 12 placebo recipients ( 5 % ) had clinical signs and symptoms of a urinary tract infection ( UTI ) ( P = 0.15 ) . In addition , no ciprofloxacin-treated patients compared with 4 placebo-treated patients ( 2 % ) were admitted to the hospital for febrile UTI after the procedure . Ciprofloxacin reduced the expected net costs of treating infectious complications after biopsy by $ 23 per patient for an overall annual savings of $ 68,195 in the five study groups when compared with placebo . CONCLUSIONS Single-dose oral ciprofloxacin reduced bacteriuria after biopsy compared with placebo in patients undergoing transrectal prostatic biopsy and provided an economic advantage . In addition , this study establishes the actual rate of bacteriuria after transrectal needle biopsy of the prostate without antibiotic prophylaxis to be 8 % with a clinical rate of UTI of 5 % and a hospitalization rate of 2 %
Widespread use of fluoroquinolone prophylaxis may be associated with an increase in resistant Escherichia coli strains , posing a potentially major health issue in the future .
INTRODUCTION Transrectal ultrasound-guided biopsies ( TRUS-gb ) are associated with both mild and serious complications .
Prophylactic antibiotics reduce the risk of septicaemia and mortality ; however , no international consensus exists on the timing and duration of antibiotics , including the optimal drug strategy .
We review ed the current evidence supporting use of prophylactic antibiotics and the risk of complications following prostate biopsies .