And rogen rise is greater in those patients who lose more weight as well as in younger , non-diabetic subjects with a greater degree of obesity .
Body weight loss is also associated with a decrease in estradiol and an increase in gonadotropins levels .
These data show that weight loss is associated with an increase in both bound and unbound testosterone levels .
The normalization of sex hormones induced by body weight loss is a possible mechanism contributing to the beneficial effects of surgery in morbid obesity
OBJECTIVE Few r and omized clinical studies have evaluated the impact of diet and physical activity on testosterone levels in obese men with conflicting results .
Conversely , studies on bariatric surgery in men generally have shown an increase in testosterone levels .
The aim of this study is to perform a systematic review and meta- analysis of available trials on the effect of body weight loss on sex hormones levels .
Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism.
OBJECTIVE Isolated hypogonadotropic hypogonadism ( IHH ) is frequently observed in severely obese men , probably as a result of increased estradiol ( E(2 ) ) production and E(2)-mediated negative feedback on pituitary LH secretion . Aromatase inhibitors can reverse this process . This study evaluates whether letrozole once a week can normalize serum testosterone in severely obese men and maintain its long term effect . DESIGN Open , uncontrolled 6-month pilot study in 12 severely obese men ( body mass index>35.0 kg/m(2 ) ) with obesity-related IHH and free testosterone levels < 225 pmol/l , treated with  2.5 mg letrozole once a week for 6 months . RESULTS Six weeks of treatment reduced total E(2 ) from 123+/-11 to 58+/-7 pmol/l ( P<0.001 , mean+/-s.e.m . ) , and increased serum LH from 4.4+/-0.6 to 11.1+/-1.5 U/l ( P<0.001 ) . Total testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l ( P<0.001 ) , and free testosterone from 163+/-13 to 604+/-50 pmol/l ( P<0.001 ) . Total testosterone rose to within the normal range in all subjects , whereas free testosterone rose to supraphysiological levels in 7 out of 12 men . The testosterone and E(2 ) levels were stable throughout the week and during the 6-month treatment period . CONCLUSION Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH . However , free testosterone frequently rose to supraphysiological levels . Therefore , a starting dose < 2.5 mg once a week is recommended
And rogen rise is greater in those patients who lose more weight as well as in younger , non-diabetic subjects with a greater degree of obesity .
Body weight loss is also associated with a decrease in estradiol and an increase in gonadotropins levels .
These data show that weight loss is associated with an increase in both bound and unbound testosterone levels .
The normalization of sex hormones induced by body weight loss is a possible mechanism contributing to the beneficial effects of surgery in morbid obesity
OBJECTIVE Few r and omized clinical studies have evaluated the impact of diet and physical activity on testosterone levels in obese men with conflicting results .
Conversely , studies on bariatric surgery in men generally have shown an increase in testosterone levels .
The aim of this study is to perform a systematic review and meta- analysis of available trials on the effect of body weight loss on sex hormones levels .