The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Post-exercise reduction in blood pressure in hypertensive subjects: effects of angiotensin converting enzyme inhibition.
1 . Much attention has been given to the effects of various classes of antihypertensive drugs on blood pressure and haemodynamics . The effects of a single bout of exercise on post-exercise blood pressure have also been studied by several investigators . However , the combined effects of prior exercise and antihypertensive medication has drawn less attention . 2 . We examined the separate and combined effects of a single bout of exercise and of angiotensin converting enzyme ( ACE ) inhibition with a new ACE inhibitor ( fosinopril , 20 mg day(-1 ) ) on post-exercise blood pressure and systemic and regional haemodynamics .  Ten patients with mild-to-moderate hypertension were studied with a double-blind , r and omized crossover , placebo- and rest period-controlled study design . 3 . At rest , mean arterial pressure ( MAP , -10 + /- 2 mm Hg ) , total peripheral resistance ( TPR , -11 + /- 5 % ) and forearm vascular resistance ( FVR , -17 + /- 8 % ) were significantly ( P < 0.05 ) reduced during ACE inhibition as compared with the placebo phase . 4 . During the placebo phase , MAP ( -3 + /- 1 mm Hg ) , TPR ( -10 + /- 4 % ) and FVR ( -9 + /- 4 % ) were lower after exercise as compared with the control rest period . 5 . During ACE inhibition , MAP ( -3 + /- 1 mm Hg ) and TPR (-8 + /- 4 % ) were lower , but FVR ( + 32 + /- 15 % ) was increased after exercise as compared with the control rest period . 6 . Thus , blood pressure and TPR decreased similarly after exercise during the placebo phase and during ACE inhibition . However , differences in post-exercise forearm haemodynamics during the placebo phase and during ACE inhibition indicate that underlying regional haemodynamics are modified
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .