Conclusions The use of sedatives and hypnotics and antidepressants including tricyclic antidepressants , selective serotonin reuptake inhibitors , and serotonin norepinephrine reuptake inhibitors appears to be related with an increased risk of falls .
It is not clear if the use of antihypertensive medications is associated with the risk of falls in older people
Purpose Falls are an important public health problem in older people .
Medication use is considered a risk factor for falls .
This study systematic ally review ed recent studies to determine the medications that might be associated with the risk of falling in older people .
Central nervous system medications and falls risk in men aged 60-75 years: the Study on Male Osteoporosis and Aging (SOMA).
INTRODUCTION drugs acting on the central nervous system ( CNS ) increase falls risk . Most data on CNS drugs and falls are in women/mixed-sex population s. This study assessed the relationship between  CNS drugs  and  falls in men aged 60 - 75 years . METHODS a question naire was sent to r and omly selected Danish men aged 60 - 75 years . Cross-sectional data on CNS drugs and falls in the previous year were available for 4,696 men . Logistic regression investigated the relationship between falls and CNS drugs .  RESULTS the median age was 66.3 ( IQR = 63.1 - 70.0 ) years ; 21.7 % were fallers . The following were associated with fallers ( OR ; 95 % CI ) : opiates ( 2.4 ; 1.5 - 3.7 ) , other analgesics ( 1.7 ; 1.4 - 2.1 ) , antiepileptics ( 2.8 ; 1.5 - 5.1 ) , antidepressants ( 2.8 ; 1.9 - 4.1 ) and anxiolytics/hypnotics ( 1.5 ; 0.9 - 2.6 ) . Effects of opiates interacted strongly and significantly with age , with a marked association with falls in the older half of the subjects only . No significant associations were found between antipsychotics and fallers . Selective serotonin reuptake inhibitors and tricyclics were significantly associated with fallers ( 3.1 ; 2.0 - 5.0 and 2.2 ; 1.0 - 4.7 , respectively ) . CONCLUSION several CNS drug classes are associated with an approximately 2 - 3-fold increase risk of falls in men aged 60 - 75 years r and omly selected from the population . Further longitudinal data are now required to confirm and further investigate the role of CNS drugs in falls causation in men
Conclusions The use of sedatives and hypnotics and antidepressants including tricyclic antidepressants , selective serotonin reuptake inhibitors , and serotonin norepinephrine reuptake inhibitors appears to be related with an increased risk of falls .
It is not clear if the use of antihypertensive medications is associated with the risk of falls in older people
Purpose Falls are an important public health problem in older people .
Medication use is considered a risk factor for falls .
This study systematic ally review ed recent studies to determine the medications that might be associated with the risk of falling in older people .