Conclusion Neither HIIT nor MICT is superior for altering TC , TRG , or LDL-C , or TC-HDL-C ratio .
To raise HDL-C , HIIT may result in a larger effect size compared with MICT .
Objective To compare the effects of moderate intensity continuous training ( MICT ) and high intensity interval training ( HIIT ) on  adult lipid profiles ;  to identify training or participant characteristics that may determine exercise-induced change in total cholesterol ( TC ) , triglycerides ( TRG ) , high-density lipoprotein cholesterol ( HDL-C ) and low-density lipoprotein cholesterol ( LDL-C ) .
Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms
Background — Higher levels of physical activity are associated with fewer cardiovascular disease  (  CVD ) events . Although the precise mechanisms underlying this inverse association are unclear , differences in several cardiovascular risk factors may mediate this effect . Methods and Results — In a prospect i ve study of 27 055 apparently healthy women , we measured baseline levels of hemoglobin A1c , traditional lipids ( total , low-density lipoprotein , and high-density lipoprotein cholesterol ) , novel lipids [ lipoprotein(a ) and apolipoprotein A1 and B-100 ] , creatinine , homocysteine , and inflammatory/hemostatic biomarkers  ( high-sensitivity C-reactive protein , fibrinogen , soluble intracellular adhesion molecule-1 ) and used women 's self-reported physical activity , weight , height , hypertension , and diabetes . Mean follow-up was 10.9±1.6 years , and 979 incident CVD events occurred . The risk of CVD decreased linearly with higher levels of activity ( P for linear trend < 0.001 ) . Using the reference group of < 200 kcal/wk of activity yielded age- and treatment-adjusted relative risk reductions associated with 200 to 599 , 600 to 1499 , and ≥1500 kcal/wk of 27 % , 32 % , and 41 % , respectively . Differences in known risk factors explained a large proportion ( 59.0 % ) of the observed inverse association . When sets of risk factors were examined , inflammatory/hemostatic biomarkers made the largest contribution to lower risk ( 32.6 % ) , followed by blood pressure ( 27.1 % ) . Novel lipids contributed less to CVD risk reduction compared with traditional lipids ( 15.5 % and 19.1 % , respectively ) . Smaller contributions were attributed to body mass index ( 10.1 % ) and hemoglobin A1c/diabetes ( 8.9 % ) , whereas homocysteine and creatinine had negligible effects ( < 1 % ) . Conclusions — The inverse association between  physical activity  and CVD risk is mediated in substantial part by known risk factors , particularly inflammatory/hemostatic factors and blood pressure
Conclusion Neither HIIT nor MICT is superior for altering TC , TRG , or LDL-C , or TC-HDL-C ratio .
To raise HDL-C , HIIT may result in a larger effect size compared with MICT .
Objective To compare the effects of moderate intensity continuous training ( MICT ) and high intensity interval training ( HIIT ) on  adult lipid profiles ;  to identify training or participant characteristics that may determine exercise-induced change in total cholesterol ( TC ) , triglycerides ( TRG ) , high-density lipoprotein cholesterol ( HDL-C ) and low-density lipoprotein cholesterol ( LDL-C ) .