Results Prophylactic antibiotics  prevent inflammatory complications after gynaecological surgery .
Prophylactic antibiotics are more effective in surgery requiring access to the peritoneal cavity or the vagina .
Cefotetan appears to be more capable in preventing the overall inflammatory complication rate than cefoxitin or cefazolin .
No benefit has been shown for the combination of antibiotics as prophylaxis .
No difference has been shown between the long-term and short-term use of antibiotics .
There is no need for the primary use of an anaerobic antibacterial agent .
Conclusion Antibiotics help to prevent postoperative inflammatory complications after major gynecologic surgeries
Purpose The aim of this study was to systematic ally review the literature on antibiotic prophylaxis in gynaecologic surgeries to prevent inflammatory complications after gynaecological operations .
Single-dose Piperacillin Versus Triple-dose Cefoxitin Prophylaxis at Vaginal and Abdominal Hysterectomy
Two hundred fourteen women having vaginal or abdominal hysterectomy were entered into a prospect i ve , r and omized , blind clinical trial comparing a preoperative intravenous dose of piperacillin to three perioperative intravenous doses of cefoxitin given over an eight-hour period . Interregimen clinical , surgical , and outcome variables of the 207 evaluable subjects were statistically similar , but there were significant interprocedure differences in a variety of categories ; many benefits exist when vaginal hysterectomy is possible . Efficacy of a single dose of piperacillin was similar to that of three cefoxitin doses . Seven women ( 3.4 % ) had major postoperative infection requiring parenteral antimicrobial  therapy , two ( 1.9 % ) after vaginal hysterectomy and five ( 4.8 % ) after abdominal hysterectomy . Three of the latter five infections ( 60 % ) occurred after discharge from the hospital . Even with prophylaxis , postoperative anemia was associated with increased frequency of infection at the operative site after both procedures , and diabetes was associated with late infection of the abdominal incision after abdominal hysterectomy
Results Prophylactic antibiotics  prevent inflammatory complications after gynaecological surgery .
Prophylactic antibiotics are more effective in surgery requiring access to the peritoneal cavity or the vagina .
Cefotetan appears to be more capable in preventing the overall inflammatory complication rate than cefoxitin or cefazolin .
No benefit has been shown for the combination of antibiotics as prophylaxis .
No difference has been shown between the long-term and short-term use of antibiotics .
There is no need for the primary use of an anaerobic antibacterial agent .
Conclusion Antibiotics help to prevent postoperative inflammatory complications after major gynecologic surgeries
Purpose The aim of this study was to systematic ally review the literature on antibiotic prophylaxis in gynaecologic surgeries to prevent inflammatory complications after gynaecological operations .