Effects of antihypertensive drugs on SBP variability are dose-dependent and persist when used in combinations .
Use of a high dose of a calcium channel blocker alone or in combination with other agents is therefore likely to be particularly effective in prevention of stroke
BACKGROUND AND PURPOSE Recent studies have shown that visit-to-visit blood pressure variability is a powerful risk factor for stroke , is reduced by calcium channel blockers and diuretics , and increased by β-blockers .
However , it is unknown whether these effects are dose-dependent and persist in combination with other drugs .
Efficacy of Low-Dose Hydrochlorothiazide in Combination with Telmisartan on Early Morning Blood Pressure in Uncontrolled Hypertensive Patients
Hypertensive patients whose BP was uncontrolled despite the use of antihypertensive agents , including an ARB ( c and esartan 8 mg/day or valsartan 80 mg/day ) , were enrolled . The patients were r and omly assigned to combination therapy with telmisartan 40 mg/day ( changed from current ARB ) and hydrochlorothiazide ( HCTZ ) 12.5 mg/day ( T + H , n = 32 ) or to no change in their current drug regimen ( CTL , n = 32 ) . The observation period was 12 weeks . The office and home BPs were significantly reduced in the T + H compared to those in the CTL . A sufficient and long-acting BP lowering effect , as reflected in decreased early morning BP , was obtained with the combination of low-dose HCTZ and telmisartan without apparent metabolic deterioration
Effects of antihypertensive drugs on SBP variability are dose-dependent and persist when used in combinations .
Use of a high dose of a calcium channel blocker alone or in combination with other agents is therefore likely to be particularly effective in prevention of stroke
BACKGROUND AND PURPOSE Recent studies have shown that visit-to-visit blood pressure variability is a powerful risk factor for stroke , is reduced by calcium channel blockers and diuretics , and increased by β-blockers .
However , it is unknown whether these effects are dose-dependent and persist in combination with other drugs .