Conclusions Meta- analysis of data from prospect i ve cohort studies showed small , inconsistent and non-significant associations between sedentary behavior and body weight
Background The cumulative effect of too much sedentary behavior may contribute to  weight gain and obesity .
Objective The aim of this study was to conduct a systematic review and meta- analysis of prospect i ve cohorts and r and omized controlled studies to determine the association between sedentary  behavior  and body weight and obesity in adults .
Regular activity breaks combined with physical activity improve postprandial plasma triglyceride, nonesterified fatty acid, and insulin responses in healthy, normal weight adults: A randomized crossover trial.
BACKGROUND Compared with prolonged sitting , regular activity breaks immediately lower postpr and ial glucose and insulin , but not triglyceride responses . Postpr and ial triglycerides can be lowered by physical activity but the effect is often delayed by ∼12 to 24 hours . OBJECTIVE The objective of the study was to determine whether regular activity breaks affect postpr and ial triglyceride response in a delayed manner similar to physical activity . METHODS In a r and omized crossover trial , 36 adults ( body mass index 23.9 kg/m2 [ st and ard deviation 3.9 ] ) completed four 2-day interventions : ( 1 ) prolonged sitting ( SIT ) ; ( 2 ) prolonged sitting with 30 minutes of continuous walking ( 60 % VO2max ) , at the end of Day 1 ( SIT + PAD1 ) ; ( 3 ) Sitting with 2 minutes of walking ( 60 % VO2max ) every 30 minutes ( RAB ) ; ( 4 ) A combination of the continuous walking and regular activity breaks in 2 and 3 above ( RAB + PAD1 ) . Postpr and ial plasma triglyceride , nonesterified fatty acids , glucose , and insulin responses were measured in venous blood over 5 hours on Day 2 . RESULTS Compared with SIT , both RAB ( difference : -43.61 mg/dL·5 hours ; 95 % confidence interval [ CI ] -83.66 to -2.67 ; P = .035 ) and RAB + PAD1 ( -65.86 mg/dL·5 hours ; 95 % CI -112.14 to -19.58 ; P = .005 ) attenuated triglyceride total area under the curve ( tAUC ) . RAB + PAD1 produced the greatest reductions in insulin tAUC ( -23 % ; 95 % CI -12 % to -31 % ; P < .001 ) , whereas RAB result ed in the largest increase in nonesterified fatty acids ( tAUC , 10.08 mg/dL·5 hours ; 95 % CI 5.60 - 14.84 ; P < .001 ) . There was no effect on glucose tAUC ( P = .290 ) . CONCLUSIONS Postpr and ial triglyceride response is attenuated by regular activity breaks , when measured ∼24 hours after breaks begin . Combining regular activity breaks with 30 minutes of continuous walking further improves insulinemic and lipidemic responses
Conclusions Meta- analysis of data from prospect i ve cohort studies showed small , inconsistent and non-significant associations between sedentary behavior and body weight
Background The cumulative effect of too much sedentary behavior may contribute to  weight gain and obesity .
Objective The aim of this study was to conduct a systematic review and meta- analysis of prospect i ve cohorts and r and omized controlled studies to determine the association between sedentary  behavior  and body weight and obesity in adults .