Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .
A prospective, randomized, single - blind study comparing intraplaque injection of thiocolchicine and verapamil in Peyronie's Disease: a pilot study
ABSTRACT Objectives : To compare the response to tiocolchicine and verapamil injection in the plaque of patients with Peyronie 's disease . Material s and Methods : Prospect i ve , single-blind , r and omized study , selecting patients who have presented Peyronie 's disease for less than 18 months .  Thiocolchicine 4 mg or verapamil 5 mg were given in 7 injections ( once a week ) . Patients who had received any treatment for Peyronie 's disease in the past three months were excluded . The parameters used were the International Index of Erectile Function ( IIEF-5 ) score , analysis of the curvature on pharmaco-induced erections and size of the plaque by ultrasonography . Results : Twenty-five patients were r and omized , 13 received thiocolchicine and 12 were treated with verapamil . Both groups were statistically similar . The mean curvature was 46.7 ° and 36.2 ° before and after thiocolchicine , respectively ( p=0.019 ) and 50.4 ° and 42.08 ° before and after verapamil , respectively ( p=0.012 ) . The curvature improved in 69 % of patients treated with thiocolchicine and in 66 % of those who received verapamil . Regarding sexual function , there was an increase in the IIEF-5 from 16.69 to 20.85 ( p=0.23 ) in the thiocolchicine group . In the verapamil group the IIEF-5 score dropped from 17.50 to 16.25 ( p=0.58 ) . In the thiocolchicine group , the plaque was reduced in 61 % of patients . In the verapamil group , 8 % presented decreased plaque size . No adverse event was associated to thiocolchicine . Conclusion : The use of thiocolchicine in Peyronie 's disease demonstrated improvement on penile curvature and reduction in plaque size .  Thiocolchicine presented similar results to verapamil in curvature assessment . No significant side effects were observed with the use of tiocolchicine
Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .