Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .
Intestinal and immunological effects of daily oral administration of Lactobacillus salivarius CECT5713 to healthy adults.
There is an increasing interest in the intestinal and immunological effects of probiotics . The aim of the present study is to evaluate the tolerance and beneficial effects in healthy adults of the strain , Lactobacillus salivarius CECT5713 isolated from breast milk .  A phase II , r and omized , double-blinded , placebo-controlled human clinical trial was carried out in 40 healthy adults . The Probiotic group received a daily dose of 2 x 10(8 ) CFU of L. salivarius CECT5713 in capsules during 4 weeks while volunteers of the control received only a placebo . Gastrointestinal and immunological parameters were analyzed . Results showed that L. salivarius CECT5713 was well tolerated and no adverse effects were detected . Consumption of the probiotic strain increased fecal lactobacilli counts ( 7.9+/-0.1 vs. 7.05+/-0.2 CFU/g feces , P=0.001 ) . Also , an improvement in the frequency of defecation ( P=0.04 ) was observed . Probiotic treatment induced significantly the percentage of NK cells and monocytes , as well as the plasmatic levels of immunoglobulins M , A and G , and the regulatory cytokine IL-10 ( 72.3+/-11.7 in probiotic group vs. 27.3+/-6.4 pg/mL in control group , P<0.01 ) . Thus , it can be concluded that daily administration of L. salivarius CECT5713 to healthy adults is safe and improve gut microbiota and different parameters related to immune response
Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .