Administration of antibiotic prophylaxis more than 120 minutes before incision or after incision is associated a higher risk of surgical site infections than administration less than 120 minutes before incision .
Abstract The aim of the study was to assess the effect of timing of preoperative surgical antibiotic prophylaxis ( SAP ) on  surgical site infection ( SSI )  and compare the different timing intervals .
The benefit of routine use of SAP prior to surgery has long been recognized .
However , the optimal timing has not been defined .
Intraoperative serum and tissue activity of cefazolin and cefoxitin.
We determined the intraoperative serum and wound-muscle concentrations of cefazolin and cefoxitin in 40 patients who were undergoing cholecystectomies . The study employed an open-label design in which all of the patients r and omly received cefazolin sodium ( 20 mg/kg ) or cefoxitin sodium ( 30 mg/kg ) intravenously while the patient was in the ward ( " on call " ) or with the induction of anesthesia . Multiple blood and wound-muscle sample s were collected intraoperatively and assayed for their cephalosporin concentrations . Considerable differences in intraoperative serum and tissue concentrations between antibiotics were apparent ; there were usually higher levels of cefazolin . In all of the patients who received cefazolin sodium , the antimicrobial was detectable in wound tissue at wound closure , while it was detectable in 86 % and 38 % of patients who received cefoxitin sodium with anesthesia and on call , respectively . Because cefoxitin has a much shorter elimination half-life than cefazolin it seems prudent to administer the agent as close to the start of the operation as possible , and readminister the agent every two to three hours until the wound is closed . For cefazolin , on-call administration appears to be acceptable , with readministration not required for at least four hours
Administration of antibiotic prophylaxis more than 120 minutes before incision or after incision is associated a higher risk of surgical site infections than administration less than 120 minutes before incision .
Abstract The aim of the study was to assess the effect of timing of preoperative surgical antibiotic prophylaxis ( SAP ) on  surgical site infection ( SSI )  and compare the different timing intervals .
The benefit of routine use of SAP prior to surgery has long been recognized .
However , the optimal timing has not been defined .