Conclusion The prevalence of sarcopenia depends mostly on the diagnostic cut-off points of different criteria .
Preoperative sarcopenia is a risk factor for both long-term and short-term outcomes
Background The impact of sarcopenia on the outcome of gastrointestinal ( GI ) oncological patients is still controversial .
We aim to discuss the prevalence of sarcopenia and its relation to the oncological outcome .
Marked Loss of Muscle, Visceral Fat, or Subcutaneous Fat After Gastrectomy Predicts Poor Survival in Advanced Gastric Cancer: Single-Center Study from the CLASSIC Trial
Background There is increasing interest in the influence of body composition on oncological outcomes . We evaluated the role of skeletal muscle and fat among patients with gastric cancer ( GC ) who underwent gastrectomy with or without adjuvant chemotherapy  , as well as those changes ’ associations with survival outcomes . Methods The present study evaluated 136 patients with GC who were enrolled in the CLASSIC Trial at Yonsei Cancer Center . Baseline body compositions including skeletal muscle area , Hounsfield units ( HU ) , visceral fat area , and subcutaneous fat area were measured by preoperative computed tomography ( CT ) . CT before and after the gastrectomy were used to determine the 6-month relative changes in body composition parameters . Continuous variables were dichotomized according to the best cutoff values by Contal and O’Quigley method . Results Seventy-three patients ( 53.7 % ) underwent surgery alone , and 63 patients ( 46.3 % ) underwent surgery followed by adjuvant chemotherapy . The baseline body composition parameters were not associated with disease-free survival ( DFS ) or overall survival ( OS ) . Except for the HU , the marked loss of muscle , visceral fat , or subcutaneous fat significantly predicted shorter DFS and OS . Patients with a marked loss in at least one significant body composition parameter had significantly shorter DFS ( hazard ratio 2.9 , 95 % confidence interval 1.7–4.8 , P < 0.001 ) and OS ( hazard ratio 2.9 , 95 % confidence interval 1.7–5.0 , P < 0.001 ) . Conclusions Marked loss in body composition parameters significantly predicted shorter DFS and OS among patients with GC who underwent gastrectomy .  Postoperative nutrition and active healthcare interventions could improve the prognosis of these GC patients
Conclusion The prevalence of sarcopenia depends mostly on the diagnostic cut-off points of different criteria .
Preoperative sarcopenia is a risk factor for both long-term and short-term outcomes
Background The impact of sarcopenia on the outcome of gastrointestinal ( GI ) oncological patients is still controversial .
We aim to discuss the prevalence of sarcopenia and its relation to the oncological outcome .