The meta- analysis showed a significant increase in plasma adiponectin levels following statin therapy .
Although statins are known to increase the risk for new onset diabetes mellitus , our data might suggest that the mechanism for this is unlikely to be due to a reduction in adiponectin expression
BACKGROUND AND AIMS The effect of statin therapy on plasma adiponectin levels has not been conclusively studied .
Therefore , we aim ed to evaluate this effect through a systematic review and meta- analysis of available r and omized controlled trials ( RCTs ) .
Effect of Atorvastatin on Inflammation and Modification of Vascular Risk Factors in Rheumatoid Arthritis
Objective . To investigate the effect of atorvastatin therapy on inflammation , disease activity , endothelial dysfunction , and arterial stiffness in patients with rheumatoid arthritis ( RA ) . Methods . This study included 30 patients with early RA , r and omly divided into 2 groups . Group 1 ( n = 15 ) received methotrexate ( MTX ; 0.2 mg/kg/week ; mean ( 15.5 ± SD 1.3 ) plus prednisone ( 10 mg/day ) . Group 2 ( n = 15 ) received MTX and prednisone with the same previous doses plus atorvastatin therapy ( 40 mg/day ) . Ten healthy individuals of similar age and sex served as controls  . Disease activity , lipid profile , serum malondialdehyde ( MDA ) , tumor necrosis factor-α ( TNF-α ) , resistin , adiponectin , and brachial artery flow-mediated dilation ( FMD ) were measured before and after 6 months of treatment . Results . Atorvastatin combined with MTX therapy significantly reduced serum total cholesterol , low-density lipoprotein cholesterol , and triglycerides , and increased high-density lipoprotein cholesterol ( p < 0.001 ) . Disease activity variables , serum MDA , TNF-α , resistin , adiponectin , and FMD were significantly improved by the drug combinations ( p < 0.001 ) . Conclusion . Atorvastatin therapy in patients with RA  reduced disease activity and conventional and novel vascular risk factors that promote the atheromatous lesion . Therapy was also associated with concomitant improvement in endothelial function
The meta- analysis showed a significant increase in plasma adiponectin levels following statin therapy .
Although statins are known to increase the risk for new onset diabetes mellitus , our data might suggest that the mechanism for this is unlikely to be due to a reduction in adiponectin expression
BACKGROUND AND AIMS The effect of statin therapy on plasma adiponectin levels has not been conclusively studied .
Therefore , we aim ed to evaluate this effect through a systematic review and meta- analysis of available r and omized controlled trials ( RCTs ) .