While no clinical trial to date has specifically targeted fatigue , r and omized controlled trials , systematic review s , and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue .
Fatigue is a disabling , multifaceted symptom that is highly prevalent and stubbornly persistent .
Although fatigue is a frequent complaint among patients with fibromyalgia , it has not received the same attention as pain .
Reasons for this include lack of st and ardized nomenclature to communicate about fatigue , lack of evidence -based guidelines for fatigue assessment , and a deficiency in effective treatment strategies .
Fatigue does not occur in isolation ; rather , it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain , unrefreshing sleep , anxiety , depression , cognitive difficulties , and so on .
Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms .
Measurement properties of the Medical Outcomes Study Sleep Scale in patients with fibromyalgia.
OBJECTIVE Sleep problems are a common symptom of fibromyalgia ( FM ) . The objective of this study was to evaluate the Medical Outcomes Study ( MOS ) Sleep Scale as a measure of FM-related sleep problems . METHODS Analyses were based on data from the 1056 and 1077 studies , two r and omized , double-blind , placebo-controlled trials of pregabalin for adults with FM .  MOS Sleep Scale scores of study patients were compared with United States normative scores using a one- sample Z test . Subscale structure of the MOS was evaluated by confirmatory factor analyses , internal consistency was evaluated using Cronbach 's alpha reliability coefficients . Estimated clinical ly important differences ( CID ) in MOS Sleep Disturbance subscale scores were evaluated using mixed-effects models of change in subscale scores as a function of the Patient Global Impression of Change ( PGIC ) . RESULTS 1056 and 1077 included 748 and 745 patients , respectively . Most patients were female ( 1056 : 94.4 % , 1077 : 94.5 % ) and white ( 1056 : 90.2 % , 1077 : 91.0 % ) . Mean ages were 48.8 years ( 1056 ) and 50.1 years ( 1077 ) .  Baseline MOS Sleep Scale scores were statistically ( P<0.001 ) and substantially poorer than general population values . The MOS subscale structure was confirmed in both studies at each assessment except at baseline in the 1056 study . Cronbach 's alpha coefficients were acceptable , at least 0.70 , for all multi-item scales at baseline and end-of- study assessment s in both studies , with the exception of the Sleep Adequacy subscale at baseline . The estimated CID for the MOS Sleep Disturbance subscale was 7.9 . CONCLUSIONS The MOS Sleep Scale is an appropriate measure of FM-related sleep problems . These analyses provide the foundation for further use and evaluation of the MOS Sleep Scale in FM patients
While no clinical trial to date has specifically targeted fatigue , r and omized controlled trials , systematic review s , and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue .
Fatigue is a disabling , multifaceted symptom that is highly prevalent and stubbornly persistent .
Although fatigue is a frequent complaint among patients with fibromyalgia , it has not received the same attention as pain .
Reasons for this include lack of st and ardized nomenclature to communicate about fatigue , lack of evidence -based guidelines for fatigue assessment , and a deficiency in effective treatment strategies .
Fatigue does not occur in isolation ; rather , it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain , unrefreshing sleep , anxiety , depression , cognitive difficulties , and so on .
Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms .