Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .
Antibiotic prophylaxis in elective cholecystectomy: a randomized, double blinded study comparing ciprofloxacin and cefuroxime.
A prospect i ve , r and omised and double blind study was undertaken to compare the prophylactic efficacy of ciprofloxacin and cefuroxime in 155 patients undergoing elective cholecystectomy . Patients with past history of jaundice or presence of jaundice , diabetes mellitus , common bile duct stones and previous biliary tract surgery were excluded . Patients were allocated to the following groups : group A-no antibiotic ( n = 30 ) ; group B-ciprofloxacin ( 200 mg i/v before surgical incision and a second dose after 12 hrs ) ( n + 45 ) ; group C-ciprofloxacin given only post operatively ( 200 mg i/v , 12 hourly X 2 days followed by oral 500 mg twice daily X 3 days ) ( n = 35 ) ; group D-cefuroxime ( 750 mg i/v before surgical incision and a second dose after 12 hrs ) ( n = 45 ) . Efficacy of the antibiotic was defined as a patient being free of post operative wound infection . Maximum numbers of infection occurred in group A ( 26.67 % ) and group C ( 25.71 % ) . The incidence of wound infection was significantly lower when ciprofloxacin was used as prophylaxis ( group B ) than when used post operatively ( group C ) only ( P < 0.05 ) . Patients who received ciprofloxacin ( group B ) and cefuroxime ( group D ) as prophylaxis had significantly reduced incidence of infection ( 4.44 % and 6/67 % respectively ) ; no statistically significant difference was found between these groups . Ciprofloxacin could be used as prophylactic antimicrobial in elective cholecystectomy in developing countries because of its effectiveness , economy and ready availability
Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .