Monotherapy with either fibrates or statins suggested a significantly greater effect of fibrates in lowering plasma Fib concentrations .
According to these findings , mechanisms associated with fibrinogen metabolism might be responsible for the distinct effects of statins and fibrates in reducing cardiovascular endpoints
BACKGROUND Several studies suggest differences between fibrates and statins in lowering plasma fibrinogen ( Fib ) concentrations , but the evidence is not definitive .
Therefore , the aim of this meta- analysis of head-to-head r and omized trials was to compare the efficacy of statins and fibrates on plasma Fib concentrations .
Hemorheologic and Coagulative Pattern in Hypercholesterolemic Subjects Treated with Lipid-Lowering Drugs
The effects on the coagulative and rheologic pattern of two lipid-lowering drugs , bezafibrate and simvastatin , were studied in 36 hypercholesterolemic subjects . Patients were r and omly divided into two groups ( 18 subjects each ) and received bezafibrate R 400 mg/day or simvastatin 10 - 40 mg/day over a twelve week period . Besides a decrease in plasma fibrinogen and fibrinopeptide A ( p<0.001 both ) , bezafibrate induced a reduction of factor VIIc and VIIIc activity ( p<0.001 both ) , while antithrombin 3 activity was increased ( p<0.001 ) and the hemorheologic pattern was greatly improved ( p<0.001 ) . Simvastatin caused a slight decrease in factor VIIIc activity and a moderate reduction of beta thromboglobulin . The efficacy of bezafibrate in reducing the activation of the coagulative cascade and improving the hemorheologic pattern has been con firmed ; the peculiar triglycerides- and fibrinogen-lowering effect of the drug , not observed with simvastatin , could be responsible for these modifications
Monotherapy with either fibrates or statins suggested a significantly greater effect of fibrates in lowering plasma Fib concentrations .
According to these findings , mechanisms associated with fibrinogen metabolism might be responsible for the distinct effects of statins and fibrates in reducing cardiovascular endpoints
BACKGROUND Several studies suggest differences between fibrates and statins in lowering plasma fibrinogen ( Fib ) concentrations , but the evidence is not definitive .
Therefore , the aim of this meta- analysis of head-to-head r and omized trials was to compare the efficacy of statins and fibrates on plasma Fib concentrations .