No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .
Oral azithromycin versus doxycycline in meibomian gland dysfunction: a randomised double-masked open-label clinical trial
Background / aims To assess the efficacy and safety of oral azithromycin compared with oral doxycycline in patients with meibomian gl and dysfunction ( MGD ) who had failed to respond to prior conservative management . Methods 110 patients ( > 12 years old ) with MGD were r and omly assigned to receive either oral 5-day azithromycin ( 500 mg on day 1 and then 250 mg/day ) or 1-month doxycycline ( 200 mg/day ) . They also continued eyelid warming/cleaning and artificial tears . A score comprising five symptoms and seven signs ( primary outcome ) was recorded prior to treatment and at 1 week , and 1 and 2 months after treatment . Total score was the sum of both scores at each follow-up . Side effects were recorded and overall clinical improvement was categorised as excellent , good , fair or poor based on the percentage of change in the total score . Results Symptoms and signs improved significantly in both groups ( p=0.001 ) . While improvement of symptoms was not different between the groups , bulbar conjunctival redness ( p=0.004 ) and ocular surface staining ( p=0.01 ) were significantly better in the azithromycin group . The azithromycin group showed a significantly better overall clinical response ( p=0.01 ) . Mild gastrointestinal side effects were not significantly different between the groups except for the second visit , when the doxycycline group had significantly more side effects ( p=0.002 ) . Conclusions Although both oral azithromycin and doxycycline improved the symptoms of MGD , 5-day oral azithromycin is recommended for its better effect on improving the signs , better overall clinical response and shorter duration of treatment . Trial registration number NCT01783860
No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .