Direct comparison of doses did not show evidence of dose dependence for blood pressure-lowering for any of the other thiazides for which RCT data were available : bendrofluazide , chlorthalidone , cyclopenthiazide , metolazone or indapamide .
This is based on an informal indirect comparison of results observed in other Cochrane review s on ACE inhibitors , ARBs and renin inhibitors compared with placebo , which used similar inclusion /exclusion criteria to the present review .Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides .
These effects were dose-related and were least for hydrochlorothiazide .
Chlorthalidone increased serum glucose but the evidence was unclear for other thiazides .
This systematic review shows that hydrochlorothiazide has a dose-related blood pressure-lowering effect .
Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides
BACKGROUND Hypertension is a modifiable cardiovascular risk factor .
Although it is established that low-dose thiazides reduce mortality as well as cardiovascular morbidity , the dose-related effect of thiazides in decreasing blood pressure has not been subject to a rigorous systematic review .
It is not known whether individual drugs within the thiazide diuretic class differ in their blood pressure-lowering effects and adverse effects .
OBJECTIVES To determine the dose-related decrease in systolic and /or diastolic blood pressure due to thiazide diuretics compared with placebo control in the treatment of patients with primary hypertension .
Secondary outcomes included the dose-related adverse events leading to patient withdrawal and adverse biochemical effects on serum potassium , uric acid , creatinine , glucose and lipids .
Glucose and insulin levels during diuretic therapy in hypertensive men.
We investigated serum glucose and insulin levels result ing from thiazide or thiazide-like diuretic administration and determined whether they were associated with serum or intracellular potassium or magnesium values . We also explored the role of obesity both alone and with thiazides on serum insulin and glucose . Hypertensive men were withdrawn from  diuretics  and repleted with oral potassium and magnesium and then r and omized to 2 months of treatment with ( 1 ) hydrochlorothiazide , ( 2 ) hydrochlorothiazide with oral potassium , ( 3 ) hydrochlorothiazide with oral potassium and magnesium ( 4 ) hydrochlorothiazide and triamterene , ( 5 ) chlorthalidone , or ( 6 ) placebo . Serum was available from 202 participants for insulin and glucose determinations . Mean fasting serum glucose and insulin did not change significantly after 2 months of r and omized therapy with the exception of participants r and omized to chlorthalidone , who had significant increases in both serum insulin and glucose ( P < .05 and P < .01 , respectively ) . As body mass index increased , there was a corresponding increase in serum insulin and to a lesser degree in serum glucose . Also , as body mass index increased , participants taking hydrochlorothiazide had a corresponding increase of serum insulin ( P < .05 ) . After treatment , intracellular potassium and magnesium were both associated with higher serum insulin ( P < .001 for each ) , and serum potassium was associated with higher and serum magnesium with lower serum glucose ( P < .01 for each ) . In most hypertensive men , treatment with 50 mg chlorthalidone increases glucose and insulin levels , whereas administration of 50 mg hydrochlorothiazide , with or without potassium and /or magnesium conserving strategies , does not . ( ABSTRACT TRUNCATED AT 250 WORDS
Direct comparison of doses did not show evidence of dose dependence for blood pressure-lowering for any of the other thiazides for which RCT data were available : bendrofluazide , chlorthalidone , cyclopenthiazide , metolazone or indapamide .
This is based on an informal indirect comparison of results observed in other Cochrane review s on ACE inhibitors , ARBs and renin inhibitors compared with placebo , which used similar inclusion /exclusion criteria to the present review .Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides .
These effects were dose-related and were least for hydrochlorothiazide .
Chlorthalidone increased serum glucose but the evidence was unclear for other thiazides .
This systematic review shows that hydrochlorothiazide has a dose-related blood pressure-lowering effect .
Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides
BACKGROUND Hypertension is a modifiable cardiovascular risk factor .
Although it is established that low-dose thiazides reduce mortality as well as cardiovascular morbidity , the dose-related effect of thiazides in decreasing blood pressure has not been subject to a rigorous systematic review .
It is not known whether individual drugs within the thiazide diuretic class differ in their blood pressure-lowering effects and adverse effects .
OBJECTIVES To determine the dose-related decrease in systolic and /or diastolic blood pressure due to thiazide diuretics compared with placebo control in the treatment of patients with primary hypertension .
Secondary outcomes included the dose-related adverse events leading to patient withdrawal and adverse biochemical effects on serum potassium , uric acid , creatinine , glucose and lipids .