Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .
Effectiveness of Antibiotic Prophylaxis in Non-emergency Cholecystectomy Using Data from a Population-Based Cohort Study
Abstract Background There is a variation in the administration of antibiotics prophylaxis to reduce the perceived risk of SSI in patients undergoing non-emergency cholecystectomy . The aim of this study was to determine the effectiveness of antibiotic prophylaxis following non-emergency cholecystectomy to prevent 30-day superficial surgical site infections ( SSIs ) using non-selected , nationally collected , prospect i ve data . Methods Data were extracted from the CholeS study , which examined and independently vali date d the outcomes on consecutive patients following non-emergency cholecystectomy across 166 hospitals in the UK and Irel and . Patients who received antibiotic prophylaxis were exact matched to those who did not on variables associated with antibiotic prophylaxis . The primary outcome of interest was superficial SSI , and secondary outcomes included deep SSI , readmissions , complications and re- interventions within 30 days . Results Out of a total of 7327 patients included in the study , 4468 ( 61 % ) received antibiotic prophylaxis . These were matched to patients who did not receive antibiotic prophylaxis on a range of demographic and surgical factors , leaving 1269 pairs of patients for analysis . Within this cohort , patients receiving antibiotic prophylaxis had significantly lower rates of superficial SSI ( 0.7 % vs. 2.3 % , p = 0.001 ) and all-cause complications ( 5.8 vs. 8.0 % , p = 0.031 ) , but similar rates of deep SSI ( 1.0 vs. 1.4 % , p = 0.473 ) , readmissions ( 5.2 vs. 6.2 % , p = 0.302 ) and re- interventions ( 2.6 vs. 3.7 % , p = 0.093 ) . The number needed to treat to prevent one superficial SSI was 45 ( 95 % confidence interval 24–662 ) . Conclusions Antibiotics appear effective at reducing SSI after non-emergency cholecystectomy . However , due to the high number needed to treat it is unclear whether they provide a worthwhile clinical benefit to patients
Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .