In the meta-regression analysis , changes in plasma cortisol concentrations following statin therapy were found to be independent of treatment duration .
Results of this meta- analysis of RCTs suggest a significant elevation in plasma cortisol levels following statin therapy
This study aim ed to perform a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) in order to calculate the effect size of statin therapy in changing plasma cortisol concentrations .
The Effects of Rosuvastatin on the Serum Cortisol, Serum Lipid, and Serum Mevalonic Acid Levels in the Healthy Indian Male Population
In this open-label , balanced , r and omized , placebo-controlled , parallel study , healthy male volunteers were r and omly divided into two groups . Each group received either a single oral dose of rosuvastatin 20 mg or placebo . Estimations were done at predose on day 1 of dosing ( baseline ) and 24 h postdose after days 7 and 14 . Serum cortisol and serum lipid levels were estimated using enzyme-linked immunosorbent assay kits and serum mevalonic acid ( MVA ) levels were measured using vali date d liquid chromatography – t and em mass spectrometry method . Rosuvastatin produced a statistically significant ( P < 0.05 ) decrease in total cholesterol , low-density lipoprotein cholesterol , very low-density lipoprotein cholesterol , and triglycerides . However , the increase in high-density lipoprotein cholesterol and decrease in cortisol and MVA were not statistically significant when compared to the placebo-treated group . The study showed that rosuvastatin at a dose of 20 mg/day for a period of 14 days was very potent as cholesterol-lowering agent , without any significant change in serum cortisol level in the healthy Indian male population
In the meta-regression analysis , changes in plasma cortisol concentrations following statin therapy were found to be independent of treatment duration .
Results of this meta- analysis of RCTs suggest a significant elevation in plasma cortisol levels following statin therapy
This study aim ed to perform a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) in order to calculate the effect size of statin therapy in changing plasma cortisol concentrations .