Conclusion Our study demonstrates potential beneficial effects of probiotics on inflammation , uremic toxins , and GI Symptoms in ESRD patients .
Background / Objectives We performed this systematic review and meta- analysis to evaluate effects of probiotics on inflammation , uremic toxins , and gastrointestinal ( GI ) symptoms in end-stage renal disease ( ESRD ) patients .
Use of a probiotic to decrease enteric hyperoxaluria.
BACKGROUND Patients with inflammatory bowel disease have a 10- to 100-fold increased risk of nephrolithiasis , with enteric hyperoxaluria being the major risk factor for these and other patients with fat malabsorptive states . Endogenous components of the intestinal microflora can potentially limit dietary oxalate absorption . METHODS Ten patients were studied with chronic fat malabsorption , calcium oxalate stones , and hyperoxaluria thought to be caused by jejunoileal bypass ( 1 ) and Roux-en-Y gastric bypass surgery for obesity ( 4 ) , dumping syndrome secondary to gastrectomy ( 2 ) , celiac sprue ( 1 ) , chronic pancreatitis ( 1 ) , and ulcerative colitis in remission ( 1 ) . For 3 months , patients received increasing doses of a lactic acid bacteria mixture ( Oxadrop ) , VSL Pharmaceuticals ) , followed by a washout month . Twenty-four-hour urine collection s were performed at baseline and after each month . RESULTS Mean urinary oxalate excretion fell by 19 % after 1 month ( 1 dose per day , P < 0.05 ) , and oxalate excretion remained reduced by 24 % during the second month ( 2 doses per day , P < 0.05 ) . During the third month on 3 doses per day oxalate excretion increased slightly , so that the mean was close to the baseline established off treatment . Urinary oxalate again fell 20 % from baseline during the washout period . Calcium oxalate supersaturation was reduced while on Oxadrop , largely due to the decrease in oxalate excretion , although mean changes did not reach statistical significance . CONCLUSION Manipulation of gastrointestinal ( GI ) flora can influence urinary oxalate excretion to reduce urinary supersaturation levels . These changes could have a salutary effect on stone formation rates . Further studies will be needed to establish the optimal dosing regimen
Conclusion Our study demonstrates potential beneficial effects of probiotics on inflammation , uremic toxins , and GI Symptoms in ESRD patients .
Background / Objectives We performed this systematic review and meta- analysis to evaluate effects of probiotics on inflammation , uremic toxins , and gastrointestinal ( GI ) symptoms in end-stage renal disease ( ESRD ) patients .