There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Serum cholesterol, cholesteryl ester, and high-density lipoprotein development in newborn infants: response to formulas supplemented with cholesterol and gamma-linolenic acid.
Healthy newborn infants were either breast-fed or r and omly design ated  to receive a st and ard formula , formula plus cholesterol , or formula plus gamma-linolenic acid at birth . At 0 , 7 , and 30 days of life , the following variables were measured : cholesteryl esters ( cholesteryl arachidonate , cholesteryl oleate , cholesteryl palmitate , and cholesteryl linoleate ) , high-density lipoprotein ( HDL ) cholesterol , apoproteins ( A-I , A-II , B , C-II , C-III , and E ) , and the cholesterol and apoprotein A-I content of the HDL subfractions HDL-2b , HDL-(2a + 3a ) , and HDL-(3b + 3c ) . Breast-fed infants had higher serum levels of cholesterol , cholesteryl oleate , cholesteryl palmitate , cholesteryl arachidonate , and HDL-2b than had formula-fed infants . Addition of gamma-linolenic acid to formula raised cholesteryl-arachidonate levels , and cholesterol and gamma-linolenic acid raised serum HDL-2b levels compared with those produced by unsupplemented formula . Our data suggest that both exogenous cholesterol and gamma-linolenic acid contribute to the maturation of HDL particles associated with human milk consumption in newborn infants . They may also promote adequate delivery of cholesterol and arachidonic acid to the developing brain
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .