A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .
The Effects of Modafinil, Caffeine, and Dextroamphetamine on Judgments of Simple Versus Complex Emotional Expressions Following Sleep Deprivation
Cognitive abilities such as vigilance , attention , memory , and executive functioning can be de grade d significantly following extended periods of wakefulness . Although much evidence suggests that sleep-loss induced deficits in alertness and vigilance can be reversed or mitigated by stimulants such as caffeine , it is not clear how these compounds may affect other higher level cognitive processes such as emotional perception and judgment . Following 47 h of sleep deprivation , the study examined the effect of three stimulant medications ( modafinil 400 mg , dextroamphetamine 20 mg , caffeine 600 mg ) or placebo on the ability of 54 healthy participants to discriminate and label simple emotional expressions versus complex affect blends ( created by morphing photographs of two different affective facial expressions ) . For simple affective faces , neither sleep loss nor stimulant medications made any difference on the accuracy of judgments . In contrast , for complex emotion blends , all three stimulant medications significantly improved the ability to discriminate subtle aspects of emotion correctly relative to placebo , but did not differ from one another . These findings suggest that all three stimulant medications are effective at restoring some aspects of subtle affective perception
A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .