Pooled evidence suggested that topical anaesthetic creams ( TAs ) , tramadol , selective serotonin reuptake inhibitors ( SSRIs ) , and phosphodiesterase type 5 inhibitors ( PDE5is ) are more effective at prolonging IELT comparing with placebo .
Conclusions We recommend the initial use of dapoxetine 30 mg OD for PE because it has been tested in largest and better design ed clinical trials rather than it is more effective than the other drugs studied .
TAs and tramadol 50 mg OD can be used as a viable alternative to oral treatment with SSRIs .
PDE5is combined with SSRIs are more effective than SSRIs monotherapy but are also associated with more side effects .
Purpose The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for  premature ejaculation ( PE ) .
Tramadol Use in Premature Ejaculation: Daily Versus Sporadic Treatment
Aim : Premature ejaculation ( PME ) is defined as ejaculation with the minimal sexual stimulation before , on or shortly after penetration and or before a person wishes it . It is a function of the time between intra-vaginal penetration and intra-vaginal ejaculation . Tramadol has shown efficacy in PME when used as sporadic basis . In this study , we compared the use of 100 mg of tramadol as sporadic treatment ( administered 6 - 8 h before coitus ) versus continued treatment with the objective of evaluating the therapeutic results of both modalities . We assumed our alternative hypothesis that they have similar effects . Material s and Methods : A prospect i ve study was carried out on 60 patients divided into two groups of 30 patients each .  Intra-vaginal ejaculation latency time ( IELT ) and coital frequency were measured both prior to and after the treatment . Group A received tramadol 100 mg daily for 4 weeks and on request ( sporadically ) for 4 weeks more . Group B was given placebo in the same manner . Results were statistically analyzed using the Student t-test . Results : Mean IELT prior to treatment was 59.2 s in Group A and 58.7 s in Group B. Mean pre-treatment coital frequency was 2.44 times/week for Group A and 2.13 times/week for Group B. Mean IELT was 202.5 s after continued tramadol treatment and 238.2 s after sporadic treatment in Group A. Mean IELT with daily placebo was 94.8 s and with sporadic placebo was 96.6 s. Coital frequency increased to 4.32 times/week with daily tramadol treatment and 4.86 times with sporadic treatment . Coital frequency increased to 2.88 times/week with daily placebo treatment and 3.23 times with sporadic treatment . Conclusions : The results of PME treatment with tramadol are similar with both continued and sporadic administration . The sex life of patients improved and they reported greater satisfaction with the sporadic treatment
Pooled evidence suggested that topical anaesthetic creams ( TAs ) , tramadol , selective serotonin reuptake inhibitors ( SSRIs ) , and phosphodiesterase type 5 inhibitors ( PDE5is ) are more effective at prolonging IELT comparing with placebo .
Conclusions We recommend the initial use of dapoxetine 30 mg OD for PE because it has been tested in largest and better design ed clinical trials rather than it is more effective than the other drugs studied .
TAs and tramadol 50 mg OD can be used as a viable alternative to oral treatment with SSRIs .
PDE5is combined with SSRIs are more effective than SSRIs monotherapy but are also associated with more side effects .
Purpose The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for  premature ejaculation ( PE ) .