“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .
Pravastatin decreases blood pressure in hypertensive and hypercholesterolemic patients receiving antihypertensive treatment.
BACKGROUND Previous studies have suggested that the lipid-lowering agents , statins , may help reduce blood pressure ( BP ) . The goal of the present study was to characterize the effect of pravastatin on BP in hypercholesterolemic and hypertensive patients already receiving antihypertensive drugs . METHODS AND RESULTS Eighty-two patients with hypercholesterolemia were retrospectively studied before and after 3 months of treatment with pravastatin .  Forty-four patients had hypertension ( HT group ) and were receiving antihypertensive treatment , while the remaining 38 patients were normotensive ( NT group ) . Patients in the HT group were further subdivided into those with uncontrolled or controlled BP . Pravastatin treatment significantly reduced systolic BP ( SBP ) in the HT group ( 134+/-16 to 130+/-13 mmHg , p<0.005 ) but not in the NT group ( 124+/-10 to 123+/-9 mmHg , p=0.52 ) , despite the fact that treatment significantly reduced low-density lipoprotein cholesterol in both groups ( HT group 178+/-27 to 132+/-17 mg/dl , p<0.0001 ; NT group 169+/-27 to 125+/-21 mg/dl , p<0.0001 ) . Further , pravastatin significantly decreased SBP in the uncontrolled BP group ( 148+/-7 to 138+/-12 mmHg , p<0.005 ) but not in the controlled BP group ( 122+/-10 to 123+/-9 mmHg , p=0.72 ) . CONCLUSION Concomitant use of statins and antihypertensive drugs could result in improved BP control in hypertensive patients with hypercholesterolemia
“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .