In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
The effects of sugar-free vs sugar-rich beverages on feelings of fullness and subsequent food intake.
This study compared the effects of equal volumes of sugar-rich and sugar-free beverages on feelings of hunger and fullness and the ad libitum consumption of a palatable , fat-rich snack .  Eleven healthy males consumed equal volumes ( 375 mL ) of three drinks ( sugar-rich cola , sugar-free cola , mineral water ) in r and om order on separate mornings . After 20 min , the subjects were able to snack freely on potato crisps during the next 90 min . Each subject 's individual bowl of potato crisps was covertly replenished at 15 min intervals while the subjects were completing appetite and mood ratings . After the 110 min experimental period , the subjects ' ad libitum food intake from a buffet-style lunch was covertly recorded . On leaving the laboratory , the subjects filled in a weighed food dairy for the rest of the day . The equal-volume preloads initially decreased hunger to a similar degree and potato crisp intake during the first 15 min interval was not significantly different among the three preloads . On average , total energy intakes from the crisps and lunch were not significantly different among the preloads , and by the end of the day , total energy intakes were similar for the three test conditions . Therefore , the low-calorie/low-sugar drinks did not facilitate a reduced energy intake by the lean , non-dieting male subjects
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .