Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Vitamin D Supplementation and High-Density Lipoprotein Cholesterol: A Study in Healthy School Children
Background The high-density lipoprotein cholesterol ( HDL-C ) level has been shown to have a significant role in the prevention of cardiovascular diseases and atherosclerosis . Low vitamin D levels have been shown to be correlated with dyslipidemia , but limited data exist on indigenous children . Objectives We aim ed to investigate the effect of vitamin D supplementation on HDL-C levels in school-aged Iranian children . Methods In this prospect i ve controlled clinical trial , 47 healthy children ( 23 boys ) aged 10 - 14 years , students of Birj and ( Iran ) elementary schools , were selected and r and omly divided into two groups . The study group received a vitamin D supplement ( 1000 mg capsule ) daily for one month , and placebo tablets were prescribed to the controls . Before and after the treatment course , the serum HDL-C and 25-hydroxy vitamin D levels of both groups were measured . The data were analyzed by SPSS , ver . 16 , and Chi-square tests , Fisher ’s exact test , paired- sample t-tests , and Pearson ’s correlation were used , wherever appropriate . The significance level was set at P < 0.05 . Results Forty children completed the study ; their mean age was 11.5 ± 1.175 years .  The mean serum levels of both HDL-C and vitamin D showed a significant rise following the treatment in the study group ( P = 0.007 and P < 0.001 , respectively ) , whereas both variables decreased slightly in the control group ( P = 0.27 ) . There was no statistically significant difference in the mean serum levels of HDL-C and vitamin D between the two groups after the intervention ( P = 0.11 and P = 0.20 , respectively ) . Conclusions Vitamin D supplements seem to have a positive impact on serum HDL-C levels and may be effective in reducing the risk of cardiovascular diseases in the long term
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .