Regular physical activity is beneficial for reducing mortality in patients with high BP .
BACKGROUND Physical activity has been shown to be beneficial for the prevention and management of hypertension .
In the general population , physical activity has been shown to decrease mortality .
PURPOSE The purpose of this systematic review was to identify and synthesize the literature examining the impact of physical activity on mortality in patients with high blood pressure ( BP ) .
Weight loss in combination with physical activity improves endothelial dysfunction in human obesity.
OBJECTIVE To test whether weight loss may improve endothelial dysfunction in human obesity , we recruited 28 healthy obese subjects , aged 30 - 46 years , with BMI 30 - 43 kg/m(2 ) . RESEARCH DESIGN AND METHODS Endothelium-dependent and -independent vasodilation were investigated by intra-arterial infusion of increasing doses of acetylcholine ( ACh ; 7.5 , 15 , and 30 microg x ml(-1 ) x min(-1 ) ) and sodium nitroprusside ( 0.8 , 1.6 , and 3.2 microg x ml(-1 ) x min(-1 ) ) . Insulin resistance was estimated by homeostasis model assessment ( HOMA ) . Weight loss was obtained by caloric restriction and physical activity . RESULTS We observed a significant reduction in BMI ( from 33.1 + /- 4.2 to 27.5 + /- 4.5 kg/m(2 ) , -16.9 % , P < 0.0001 ) and in waist circumference ( from 108.2 + /- 12.1 to 96.8 + /- 12.9 cm , -10.5 % , P < 0.0001 ) . Weight loss was also associated with a significant increase in ACh-stimulated forearm blood flow ( FBF ) , from 7.4 + /- 2.8 to 12.9 + /- 3.4 ml . 100 ml(-1 ) of tissue x min(-1 ) kg/m(2 ) ( P < 0.0001 ) . Multivariate regression analysis demonstrated that the only independent predictor of FBF was HOMA , accounting for 44.5 % of the variation , whereas the addition of BMI explained another 2.3 % of the variation . CONCLUSIONS Our data demonstrate that energy-restricted diet associated with physical activity induce a significant and clinical ly relevant improvement in ACh-stimulated vasodilation in obese healthy subjects
Regular physical activity is beneficial for reducing mortality in patients with high BP .
BACKGROUND Physical activity has been shown to be beneficial for the prevention and management of hypertension .
In the general population , physical activity has been shown to decrease mortality .
PURPOSE The purpose of this systematic review was to identify and synthesize the literature examining the impact of physical activity on mortality in patients with high blood pressure ( BP ) .