This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
Effects of a single post-partum injection of a high dose of vitamin D on glucose tolerance and insulin resistance in mothers with first-time gestational diabetes mellitus.
AIM This study was performed to determine the effect of a single , large , intramuscular injection of vitamin D post-partum on glucose tolerance and insulin resistance in women with gestational diabetes . METHODS Forty-five participants in a r and omized controlled trial on gestational diabetes mellitus were divided into an intervention group and a control group . Only subjects in the intervention group received one intramuscular injection of 300,000 IU of vitamin D3 .  HbA(1c ) , serum 25-hydroxyvitamin D3 , fasting insulin and blood glucose , C-peptide , homeostasis model assessment insulin resistance index ( HOMA-IR ) , β-cell function , insulin sensitivity and the Quantitative Insulin Sensitivity Check Index ( QUICKI ) were measured at baseline and after 3 months of intervention . RESULTS Approximately 80 % of the mothers had a degree of vitamin D deficiency . Post-intervention , this was found in 4.2 and 71.4 % in the intervention and control groups , respectively . The medians of HOMA-IR indices before and after intervention were 0.6 and 0.5 ( P = 0.7 ) , respectively , in subjects in the intervention group , and 0.5 and 0.9 ( P = 0.01 ) in subjects in the control group . The mean of the QUICKI fell only in the control group ( P = 0.008 ) . In the control group , β-cell function increased by ~8 % ( P = 0.01 ) and insulin sensitivity decreased after 3 months ( P = 0.002 ) . Post-intervention , the median C-peptide decreased in the intervention group and increased in the control group , but the change was significant only in the control group ( P = 0.03 ) . CONCLUSIONS A single injection of 300,000 IU of vitamin D3 achieves a 3-month serum 25-hydroxyvitamin D range of 50 - 80 nmol/l and is an efficient , effective and safe procedure for improving the vitamin status and indices of insulin resistance in mothers with gestational diabetes after delivery
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .