In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .
Caloric beverages consumed freely at meal-time add calories to an ad libitum meal
The objective was to compare the effects of ad libitum consumption of commonly consumed meal-time beverages on energy and fluid intakes and post-meal average subjective appetite and blood glucose in healthy adults . In a r and omized controlled design , 29 males and females consumed to satiation an ad libitum pizza meal with one of five beverages in unlimited amount including water ( 0 kcal ) , 1 % milk ( 44 kcal/100 ml ) , regular cola ( 44 kcal/100 ml ) , orange juice ( 44 kcal/100 ml ) and diet cola ( 0 kcal ) . Food and fluid intakes were measured at the meal . Average subjective appetite and blood glucose were measured before and for 2h after the meal . Although energy intake from pizza was similar among all beverage treatments , the amount of fluid consumed ( g ) varied among the beverages with intake of orange juice higher than regular and diet cola , but not different from water or milk . Meal-time ingestion of caloric beverages , milk , orange juice and regular cola , led to higher total meal-time energy intakes compared to either water or diet cola .  Post-meal blood glucose area under the curve ( AUC ) was lower after milk than after meals with water , orange juice and regular cola and post-meal average subjective appetite AUC was lower after milk than after meals with water . Meal intakes of nutrients including protein , calcium , phosphorus , zinc , vitamins B12 , A and D were higher at the meal with milk compared to the other beverages . Thus , caloric beverages consumed ad libitum during a meal add to total meal-time energy intake , but 1 % milk favors a lower post-meal blood glucose and average subjective appetite score and adds to nutrient intake
In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .