RESULTS Weight loss was associated with a decline in CRP level .
Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level
BACKGROUND Several studies suggest that weight loss reduces C-reactive protein ( CRP ) level ; however , the consistency and magnitude of this effect has not been well characterized .
Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level .
Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women.
The purpose of this study was to determine whether a hypocaloric diet with and without exercise training is effective in reducing plasma C-reactive protein , IL-6 , TNFalpha , and their soluble receptors ( sIL-6R , sTNFR1 , and sTNFR2 ) , and whether changes in these inflammatory markers are related to changes in regional lipolysis in obese ( body mass index , 32.78 + /- 4.73 ) postmenopausal women ( diet alone , n = 17 ; diet plus exercise , n = 17 ) . All inflammatory markers were measured by an ELISA method . In vitro lipolysis was evaluated by measuring glycerol release using a one-step enzymatic fluorometric technique . Six months of diet and diet plus exercise decreased total and abdominal fat to a similar degree . Diet plus exercise , but not diet alone , decreased plasma levels of C-reactive protein , IL-6 , sIL-6R , and sTNFR1 and increased basal and postreceptor stimulated lipolysis in both abdominal and gluteal regions . Changes in abdominal stimulated lipolysis correlated significantly with changes in plasma IL-6 ( r = -0.39 ) and TNFR1 ( r = -047 ) . Thus , diet plus exercise training , but not diet alone , is effective in reducing chronic inflammation in obese postmenopausal women . In addition , modification of chronic inflammation is associated with changes in local adipose tissue metabolism in response to diet and exercise
RESULTS Weight loss was associated with a decline in CRP level .
Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level
BACKGROUND Several studies suggest that weight loss reduces C-reactive protein ( CRP ) level ; however , the consistency and magnitude of this effect has not been well characterized .
Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level .