The effects are more pronounced when synbiotics supplements are consumed for > 8 weeks .
Synbiotic supplements may be beneficial to improve lipid profile , especially when they are consumed for > 8 weeks
Existing evidence on the possible effects of synbiotics on lipid profile is inconclusive .
The aim of the present systematic review was to clarify the effects of synbiotics consumption on lipid profile .
Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women.
The present study investigated the impact of a Lactobacillus rhamnosus CGMCC1.3724 ( LPR ) supplementation on weight loss and maintenance in obese men and women over 24 weeks . In a double-blind , placebo-controlled , r and omised trial , each subject consumed two capsules per d of either a placebo or a LPR formulation ( 1.6 × 10(8 ) colony-forming units of LPR/capsule with oligofructose and inulin ) . Each group was su bmi tted to moderate energy restriction for the first 12 weeks followed by 12 weeks of weight maintenance . Body weight and composition were measured at baseline , at week 12 and at week 24 . The intention-to-treat analysis showed that after the first 12 weeks and after 24 weeks , mean weight loss was not significantly different between the LPR and placebo groups when all the subjects were considered . However , a significant treatment × sex interaction was observed . The mean weight loss in women in the LPR group was significantly higher than that in women in the placebo group ( P = 0.02 ) after the first 12 weeks , whereas it was similar in men in the two groups ( P= 0.53 ) . Women in the LPR group continued to lose body weight and fat mass during the weight-maintenance period , whereas opposite changes were observed in the placebo group . Changes in body weight and fat mass during the weight-maintenance period were similar in men in both the groups . LPR-induced  weight loss in women was associated not only with significant reductions in fat mass and circulating leptin concentrations but also with the relative abundance of bacteria of the Lachnospiraceae family in faeces . The present study shows that the Lactobacillus rhamnosus CGMCC1.3724 formulation helps obese women to achieve sustainable weight loss
The effects are more pronounced when synbiotics supplements are consumed for > 8 weeks .
Synbiotic supplements may be beneficial to improve lipid profile , especially when they are consumed for > 8 weeks
Existing evidence on the possible effects of synbiotics on lipid profile is inconclusive .
The aim of the present systematic review was to clarify the effects of synbiotics consumption on lipid profile .