The present study revealed that supplementation with ALA slightly but significantly decreased body weight and BMI .
Safe dosage for ALA is up to 1200 mg/day .
However , it seems that ALA can not be cost-effective .
BACKGROUND & AIMS Previous studies have supported positive roles of antioxidant supplements on  weight-loss .
One antioxidant supplement is Alpha-lipoic acid .
However , recommending ALA as an anti-obesity supplement remains controversial .
Accordingly , the purpose of the present study was to perform a meta- analysis on the effects of ALA supplement on anthropometric indices  among adult subjects .
The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: a clinical trial
Study design : A r and omized , double-blind , placebo-controlled clinical trial . Objective : To assess the effect of alpha-lipoic acid ( ALA ) supplementation on IL-6 , hs-CRP , FBS , anthropometric indices , food intake and blood pressure in male patients with chronic spinal cord injury ( SCI ) . Setting : Imam Khomeini Hospital , Tehran University of Medical Sciences , Tehran , Iran . Methods : Fifty-eight men with chronic SCI participated in the study . Participants were divided in two groups : one group received 600 mg of supplemental ALA ( n=28 ) and the other group received placebo ( n=30 ) for 12 weeks . At the beginning and end of the study , biochemical parameters , anthropometric indices , blood pressure and dietary intakes were measured . Dietary intake was measured using N4 software , and statistical analyses were carried out using SPSS16 . Results : No significant reduction was found in IL-6 ( P=0.97 ) and hs-CRP levels ( P=0.23 ) . There was significant reduction in fasting blood sugar ( P=0.001 ) , body weight ( P=0.001 ) , BMI ( P=0.001 ) , waist circumference ( P=0.001 ) and blood pressure ( P=0.001 ) . Dietary intake was significantly reduced , including fat ( P=0.001 ) , carbohydrate ( P=0.001 ) , protein ( P=0.002 ) and energy intakes ( P=0.001 ) . Conclusion : Lipoic acid supplementation had no significant effect on the measured inflammatory markers but it reduces fasting blood sugar , anthropometric parameters , food intake and blood pressure in men with chronic SCI
The present study revealed that supplementation with ALA slightly but significantly decreased body weight and BMI .
Safe dosage for ALA is up to 1200 mg/day .
However , it seems that ALA can not be cost-effective .
BACKGROUND & AIMS Previous studies have supported positive roles of antioxidant supplements on  weight-loss .
One antioxidant supplement is Alpha-lipoic acid .
However , recommending ALA as an anti-obesity supplement remains controversial .
Accordingly , the purpose of the present study was to perform a meta- analysis on the effects of ALA supplement on anthropometric indices  among adult subjects .