Intramuscular testosterone moderately increased lumbar bone density in men ; the results on femoral neck bone density are inconclusive .
Without bone fracture data , the available trials offer weak and indirect inferences about the clinical efficacy of testosterone on osteoporosis prevention and treatment in men
CONTEXT And rogen-deficient men are at increased risk of osteoporosis .
The extent to which testosterone can prevent and treat osteoporosis in men remains unclear .
Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men.
Young adult males who can not produce or respond to estrogen ( E ) are osteopenic , suggesting that E may regulate bone turnover in men , as well as in women . Both bioavailable E and testosterone ( T ) decrease substantially in aging men , but it is unclear which deficiency is the more important factor contributing to the increased bone resorption and impaired bone formation that leads to their bone loss . Thus , we addressed this issue directly by eliminating endogenous T and E production in 59 elderly men ( mean age 68 years ) , study ing them first under conditions of physiologic T and E replacement and then assessing the impact on bone turnover of withdrawing both T and E , withdrawing only T , or only E , or continuing both . Bone resorption markers increased significantly in the absence of both hormones and were unchanged in men receiving both hormones . By two-factor ANOVA , E played the major role in preventing the increase in the bone resorption markers , whereas T had no significant effect . By contrast , serum osteocalcin , a bone formation marker , decreased in the absence of both hormones , and both E and T maintained osteocalcin levels . We conclude that in aging men , E is the dominant sex steroid regulating bone resorption , whereas both E and T are important in maintaining bone formation
Intramuscular testosterone moderately increased lumbar bone density in men ; the results on femoral neck bone density are inconclusive .
Without bone fracture data , the available trials offer weak and indirect inferences about the clinical efficacy of testosterone on osteoporosis prevention and treatment in men
CONTEXT And rogen-deficient men are at increased risk of osteoporosis .
The extent to which testosterone can prevent and treat osteoporosis in men remains unclear .