Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial
Context Results of animal models and cross-sectional cohort studies have suggested a beneficial role for vitamin D in male reproduction . Objective Determine the effect of vitamin D and calcium supplementation on semen quality in infertile men with serum 25-hydroxyvitamin-D ( 25OHD ) levels ≤50 nmol/L. Design A single-center , triple-blinded , r and omized clinical trial . Participants A total of 1427 infertile men were screened to include 330 ; 1002 men did not meet inclusion criteria and 95 did not wish to participate . Intervention The active group received cholecalciferol 300,000 IU initially , then 1400 IU cholecalciferol and 500 mg of calcium daily for 150 days ; the other group received placebo .  Results Serum concentrations of 25OHD and 1,25-dihydroxyvitamin D3 were significantly higher in men in the treatment group compared with the placebo group . Vitamin D supplementation was not associated with changes in semen parameters , although spontaneous pregnancies tended to be higher in couples in which the man was in the treatment group [ 7.3 % vs 2.4 % , Δ5.0 % ( -0.6 % ; 10.5 % ) ] . Vitamin D treatment in a subgroup of oligozoospermic men increased the chance for a live birth compared with placebo [ 35.6 % vs 18.3 % , Δ17.3 % ( 1.6 % ; 32.9 % ) ] . Moreover , serum inhibin B levels were higher in men deficient in vitamin D who were r and omly assigned to receive high-dose vitamin D [ 193 pg/mL vs 143 pg/mL , Δ49 pg/mL ( 8 ; 91 pg/mL ) ] ; however , the increase in sperm concentration was not significantly higher than in the placebo group ( P = 0.07 ) . Conclusion High-dose vitamin D supplementation did not improve semen quality in vitamin D-insufficient infertile men . The positive impact of vitamin D supplementation on live birth rate and serum inhibin B in oligozoospermic and vitamin D-deficient men may be of clinical importance and warrant verification by others
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .