A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .
A randomized, double-blind, placebo-controlled study of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder.
OBJECTIVE To evaluate the efficacy and tolerability of modafinil in children and adolescents , ages 7 to 17 , with attention-deficit/hyperactivity disorder ( ADHD ) . METHOD In this 9-week , double-blind , flexible-dose study , patients were r and omized to  once-daily modafinil ( 170 - 425 mg ) or placebo . Assessment s included ADHD Rating Scale-IV ( ADHD-RS-IV ) School and Home Versions and Clinical Global Impression of Improvement ( CGI-I ) scale . RESULTS Two hundred patients were r and omized . Modafinil produced significant reductions in ADHD-RS-IV total scores at school ( n = 128 ; mean change + /- SD : -17.5 + /- 13.1 points ) compared with placebo ( n = 66 ; -9.7 + /- 10.3 points ; p < .0001 ) . Similarly , modafinil reduced ADHD-RS-IV total scores at home compared with placebo ( -17.6 + /- 13.3 versus -7.5 + /- 11.8 points ; p < .0001 ) . Fifty-two percent of patients r and omized to modafinil and 18 % of those r and omized to placebo met pre study criteria for responder on the CGI-I ( p < .0001 ) . R and omization to modafinil was associated with significantly more insomnia , headache , decreased appetite , and weight loss than r and omization to placebo , but discontinuation attributed to adverse events did not differ statistically between treatment groups ( modafinil , 5 % ; placebo , 6 % ) . CONCLUSION Modafinil was well tolerated and reduced ADHD symptoms at school and home compared with placebo
A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .