This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
Vitamin D receptor Cdx-2-dependent response of central obesity to vitamin D intake in the subjects with type 2 diabetes: a randomised clinical trial.
This study aim ed to investigate the effects of daily intake of vitamin D-fortified yogurt drink ( doogh ) on central obesity indicators in subjects with type 2 diabetes ( T2D ) and the possible modulation of this effect by vitamin D receptor ( VDR ) Cdx-2 genotypes . A total of sixty T2D subjects were r and omly allocated to two groups to receive either plain doogh ( PD ; n 29 , containing 170 mg Ca and no vitamin D/250 ml ) or vitamin D3-fortified doogh ( FD ; n 31 , containing 170 mg Ca and 12·5 μg/250 ml ) twice a day for 12 weeks . 25-hydroxyvitamin D ( 25(OH)D ) , glycaemic as well as adiposity indicators were evaluated before and after the intervention . VDR-Cdx-2 genotypes in extended number of T2D subjects in the FD group ( n 60 ) were determined as AA , GA and GG . After 12 weeks , in FD compared with PD , serum 25(OH)D increased ( + 35·4 v. -4·8 nmol/l ; P<0·001 ) and mean changes of waist circumference ( WC ; -1·3 v. + 1·6 cm ; P=0·02 ) , body fat mass ( FM ; -1·9 v. + 0·60 % ; P=0·008 ) , truncal fat ( TF ; -1·1 v. 0·13 % ; P=0·003 ) and visceral adipose tissue ( -0·80 v. + 0·37 AU ; P<0·001 ) decreased significantly . Circulating 25(OH)D was raised only in the AA group ( 34·8 nmo/l in AA group v. -6·4 nmol/l in AG and -1·6 nmol/l in GG groups ; P<0·001 ) , which was accompanied by a significant decrease in changes of WC ( P=0·004 ) , FM% ( P=0·01 ) and TF% ( P<0·001 ) in the AA genotype . Daily intake of vitamin D-FD for 12 weeks improved the central obesity indices in T2D subjects , and the improvement was more pronounced in the carriers of the AA genotype of VDR-Cdx-2
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .