Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .
Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?
OBJECTIVES Our study compared 2 whole grain oat-based cereals with 2 refined grain wheat-based cereals to determine their effects on the need for antihypertensive medications in people with high blood pressure ( BP ) . STUDY DESIGN This 12-week , r and omized controlled parallel-group trial with = 6 weeks of voluntary follow-up was design ed to investigate the antihypertensive effects of oats . After 4 weeks of baseline feeding , medication dose was maintained or reduced by half or completely throughout the middle 4 weeks of the study . In the final 4 weeks , participants continued cereal consumption ; medication was adjusted according to the protocol . POPULATION Men and women ( n = 88 ) being treated for hypertension with a mean baseline BP below 160/100 . OUTCOMES MEASURED Primary study outcomes included change in SBP and DBP as well as antihypertensive medication reduction . Secondary measures included blood lipid , fasting glucose , and insulin levels and side effects related to elevated BP and increased dietary fiber intake . RESULTS Seventy-three percent of participants in the oats group versus 42 % in the control group were able to stop or reduce their medication by half . Treatment group participants whose medication was not reduced had substantial decreases in BP . The oats group experienced a 24.2-mg/dL reduction in total cholesterol levels , a 16.2-mg/dL decrease in low-density lipoprotein cholesterol levels , and a 15.03-mg/dL drop in plasma glucose levels vs controls . CONCLUSIONS Results suggest that a diet containing soluble fiber-rich whole oats can significantly reduce the need for antihypertensive medication and improve BP control . Considering the lipid and glucose improvements as well , increased consumption of whole oats may significantly reduce cardiovascular disease risk
Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .