Vitamin D supplementation demonstrated a small but statistically significant improvement in ADHD total scores , inattention scores , hyperactivity scores , and behavior scores .
There was no statistically significant improvement in oppositional scores .
Reported adverse events in the vitamin D group were mild and not significantly different from the control group .
Vitamin D supplementation increased serum vitamin D levels and the ratio of patients with sufficient vitamin D levels .
Conclusions : Vitamin D supplementation as adjunctive therapy to methylpheni date appeared to reduce ADHD symptoms without serious adverse events , associated with improved vitamin D status .
Objective : A systematic review and meta- analysis of r and omized controlled trials ( RCTs ) were conducted to assess the benefits and harms of vitamin D supplementation for attention-deficit/hyperactivity disorder ( ADHD ) patients .
A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder
BACKGROUND The few controlled studies of methylpheni date ( MPH ) in adults with attention deficit/hyperactivity disorder ( ADHD ) have reported equivocal results . A previous , pilot study by our group suggested that these results were due to inadequate dosing . METHOD We conducted a r and omized , 6-week , placebo-controlled , parallel study of MPH in 146 adult patients with DSM-IV ADHD using st and ardized instruments for diagnosis , separate assessment s of ADHD , depressive and anxiety symptoms , and a robust average oral daily dose of 1.1 mg/kg/day . RESULTS We found a marked therapeutic response for the MPH treatment of ADHD symptoms that exceeded the placebo response ( 76 % vs. 19 % ) . Treatment was safe and well tolerated . Response to MPH was independent of socioeconomic status , gender , and lifetime history of psychiatric comorbidity . CONCLUSIONS These results confirm that robust doses of MPH are effective in the treatment of adult ADHD
Vitamin D supplementation demonstrated a small but statistically significant improvement in ADHD total scores , inattention scores , hyperactivity scores , and behavior scores .
There was no statistically significant improvement in oppositional scores .
Reported adverse events in the vitamin D group were mild and not significantly different from the control group .
Vitamin D supplementation increased serum vitamin D levels and the ratio of patients with sufficient vitamin D levels .
Conclusions : Vitamin D supplementation as adjunctive therapy to methylpheni date appeared to reduce ADHD symptoms without serious adverse events , associated with improved vitamin D status .
Objective : A systematic review and meta- analysis of r and omized controlled trials ( RCTs ) were conducted to assess the benefits and harms of vitamin D supplementation for attention-deficit/hyperactivity disorder ( ADHD ) patients .