No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .
Hemodynamic Stabilizing Effects of L-Carnitine in Chronic Hemodialysis Patients
Background : The effects of L-carnitine on the hemodynamic state of chronic hemodialysis patients have been debated . In order to clarify the effect of administered L-carnitine on cardiac function and hypotensive episodes during the hemodialysis procedure , a r and omized double-blind placebo-controlled study was performed for 3 months . Methods and Results : Twenty stable out patients undergoing hemodialysis treatment were divided into two groups : controls ( placebo ) and treated patients ( L-carnitine 900 mg p.o . daily ) . After 3 months , cardiac function was reevaluated by echocardiography , and hypotensive episodes during hemodialysis were assessed . Free and acyl carnitine levels increased significantly from 22.3 ± 7.1 to 140.3 ± 57.5 μmol/l and from 15.8 ± 2.8 to 94.8 ± 50.4 μmol/l , respectively , in the treated group . The ejection fraction significantly increased from 61.8 ± 16.0 to 64.4 ± 13.8 % ( p < 0.05 ) in the treated group . However , there was no difference in other echocardiographic parameters between the two groups . Hypotensive episodes significantly decreased from 4.0 ± 1.7 to 1.3 ± 0.9 times per month ( p < 0.05 ) , although patients ' body weight did not change significantly . Conclusions : Beneficial effects of L-carnitine on the hemodynamic state of chronic hemodialysis patients were observed . L-Carnitine supplementation might be considered especially for chronic hemodialysis patients with unstable hemodynamic conditions
No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .