HT treatment with estrogens alone or in combination with progestogens was associated with a small to moderate improvement in sexual function , particularly in pain , when used in women with menopausal symptoms or in early postmenopause ( within five years of amenorrhoea ) , but not in unselected postmenopausal women .
The current evidence does not suggest an important effect of tibolone or of SERMs alone or combined with estrogens on sexual function .
BACKGROUND The perimenopausal and postmenopausal periods are associated with many symptoms , including sexual complaints .
OBJECTIVES To assess the effect of hormone therapy ( HT ) on  sexual function in perimenopausal and postmenopausal women .
Testosterone aromatization and cognition in women: a randomized, placebo-controlled trial
Objective : To explore whether inhibition of the conversion of testosterone to estradiol modifies the effects of testosterone on cognition in 61 healthy , estrogen-treated postmenopausal women . Design : Seventy-six postmenopausal women using transdermal estrogen for at least 8 weeks , with a serum total testosterone less than 1.2 nmol/L participated in a single-center , double-blind , r and omized , placebo-controlled study . All participants received transdermal testosterone , 400 & mgr;L of a 0.5 % testosterone gel , daily and were r and omized to receive either letrozole 2.5 mg/day or an identical placebo tablet . The main outcome measure was cognition , evaluated using a comprehensive battery of st and ardized neuropsychological tests , at baseline and week 16 . Results : Thirty women in each group completed the study .  Free testosterone increased from baseline in both groups , with no difference between groups . Free testosterone levels achieved were below the 90th centile for young women in 80 % of the participants at week 16 . Serum estradiol and sex hormone-binding globulin levels did not differ from baseline or between groups during the study . No clinical ly significant effects of testosterone treatment were seen for attention and working memory , psychomotor speed , or executive function . Significant improvements were seen for immediate and delayed visual and verbal memory and for simple concentration with testosterone therapy , all of which were unaffected by the aromatase inhibitor . Conclusions : We did not observe any effects of aromatase inhibition on cognition in healthy , estrogen-treated postmenopausal women treated with testosterone . This may be due to insufficient study power or a true lack of effect . However , our findings highlight that the detection of subtle changes in cognition in well women require the development of sensitive instruments and large r and omized , controlled trials
HT treatment with estrogens alone or in combination with progestogens was associated with a small to moderate improvement in sexual function , particularly in pain , when used in women with menopausal symptoms or in early postmenopause ( within five years of amenorrhoea ) , but not in unselected postmenopausal women .
The current evidence does not suggest an important effect of tibolone or of SERMs alone or combined with estrogens on sexual function .
BACKGROUND The perimenopausal and postmenopausal periods are associated with many symptoms , including sexual complaints .
OBJECTIVES To assess the effect of hormone therapy ( HT ) on  sexual function in perimenopausal and postmenopausal women .