In the meta-regression analysis , changes in plasma cortisol concentrations following statin therapy were found to be independent of treatment duration .
Results of this meta- analysis of RCTs suggest a significant elevation in plasma cortisol levels following statin therapy
This study aim ed to perform a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) in order to calculate the effect size of statin therapy in changing plasma cortisol concentrations .
Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial
Epidemiological and clinical studies have suggested that powerful cholesterol lowering may have adverse effects on mood and psychological well-being . Inhibition of cholesterol bio synthesis by simvastatin ( a hydroxymethyl glutaryl coenzyme A reductase inhibitor ) may also reduce steroid hormone bio synthesis . To explore if mood changes are related with steroid hormone levels , we design ed a r and omized double-blind placebo-controlled crossover trial . The separate and combined effects of a Mediterranean-type diet intervention and treatment with simvastatin 20 mg/day PO for 12 weeks were studied in 120 hypercholesterolemic but otherwise healthy middle-aged men .  Psychological functioning was assessed with question naires , and steroid hormone levels in blood were assayed radioimmunologically before and after the treatments . Simvastatin result ed in a statistically significant increase of depression and somatization without changes in the anxiety , hostility or aggression scores . Mood changes seemed to be unrelated with the statistically significant but clinical ly insignificant decline in serum testosterone levels and unrelated with the increase in serum dehydroepi and rosterone levels
In the meta-regression analysis , changes in plasma cortisol concentrations following statin therapy were found to be independent of treatment duration .
Results of this meta- analysis of RCTs suggest a significant elevation in plasma cortisol levels following statin therapy
This study aim ed to perform a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) in order to calculate the effect size of statin therapy in changing plasma cortisol concentrations .