There were no statistically significant differences in mortality , infections overall and adverse events .
Perioperative antibiotic prophylaxis of ≥24 hours may be more efficacious in preventing sternal SSIs in patients undergoing cardiac surgery compared to shorter regimens .
OBJECTIVE We aim ed to compare the efficacy of short-term ( < 24 hours ) versus longer-term antibiotic prophylaxis ( ≥24 hours ) in open heart surgery .
BACKGROUND The optimal duration of antibiotic prophylaxis for adults undergoing cardiac surgery is unknown and guideline recommendations are inconsistent .
Prospective randomised comparison of single-dose versus multiple-dose cefuroxime for prophylaxis in coronary artery bypass grafting
To assess the efficacy of single-dose antibiotic prophylaxis in coronary artery bypass grafting , 1,016 consecutive patients were prospect ively r and omized to receive either a single dose or a three-day course of cefuroxime . Nine patients ( 0.9 % ) died within seven days ; no death was caused by infection . For various reasons 163 other patients were not evaluable . Therefore , 844 patients were evaluated . Patients in group A ( n=419 ) received 20 mg/kg cefuroxime intravenously at induction of anaesthesia ; group B ( n=425 ) received the same dose followed by 750 mg t.i.d . for three consecutive days . Both groups were comparable regarding all risk factors . The efficacy of the prophylactic regimens was evaluated by comparison of occurrence of wound infection in both groups . No significant differences in wound infection were observed between the two treatment groups : sternal site infection in the single-dose prophylaxis group was 14 % versus 13 % in the three-day course group ; donor site infection occurred in 38 % versus 39 % . It is concluded that in coronary artery bypass grafting a single dose of cefuroxime is as effective as a three-day course in the prevention of wound infection
There were no statistically significant differences in mortality , infections overall and adverse events .
Perioperative antibiotic prophylaxis of ≥24 hours may be more efficacious in preventing sternal SSIs in patients undergoing cardiac surgery compared to shorter regimens .
OBJECTIVE We aim ed to compare the efficacy of short-term ( < 24 hours ) versus longer-term antibiotic prophylaxis ( ≥24 hours ) in open heart surgery .
BACKGROUND The optimal duration of antibiotic prophylaxis for adults undergoing cardiac surgery is unknown and guideline recommendations are inconsistent .