Our study suggests that methylpheni date retains its efficacy in children with ADHD and borderline intellectual functioning or ID
Attention-deficit/hyperactivity disorder ( ADHD ) frequently co-occurs with intellectual disability in children , and may further compromise learning .
Methylpheni date is a first-line treatment for ADHD , however no previous meta- analysis has evaluated its overall efficacy for ADHD in children with comorbid intellectual disability ( ID ) or borderline intellectual functioning .
Fenfluramine and methylphenidate in children with mental retardation and ADHD: clinical and side effects.
Each of 28 nonautistic children with attention-deficit hyperactivity disorder and mental retardation received placebo , methylpheni date ( 0.4 mg/kg/day ) , and fenfluramine ( gradually increased to 1.5 mg/kg/day ) for 4 weeks each in a double-blind , crossover design . Teacher ratings indicated significant improvements with both active drugs on subscales design ated as Conduct Problem , Hyperactivity , and Irritability , but methylpheni date alone produced improvements on an Inattention subscale . Parent ratings indicated significant improvements with both drugs on subscales labeled Hyperactivity , Motor Excess , and Conduct Problem . Fenfluramine alone caused improved parent ratings on Irritability and Inappropriate Speech , and on Conners ' Abbreviated Symptom Question naire . Unlike a previous study , subgroup analyses failed to show a significantly better clinical response to methylpheni date for subjects with higher mental ages , although children with higher IQs responded better than those with IQs less than 45 . The active drugs had contrasting effects on heart rate and blood pressure .  Fenfluramine caused significant weight reductions relative to both placebo and methylpheni date . These findings suggest that both methylpheni date and fenfluramine have useful , but somewhat different , clinical effects in certain children with attention-deficit hyperactivity disorder and mental retardation
Our study suggests that methylpheni date retains its efficacy in children with ADHD and borderline intellectual functioning or ID
Attention-deficit/hyperactivity disorder ( ADHD ) frequently co-occurs with intellectual disability in children , and may further compromise learning .
Methylpheni date is a first-line treatment for ADHD , however no previous meta- analysis has evaluated its overall efficacy for ADHD in children with comorbid intellectual disability ( ID ) or borderline intellectual functioning .