Mixed results were found for zinc , folic acid , vitamin C , and tryptophan , with nonsignificant results for inositol .
No major adverse effects were noted in the studies ( aside from minor digestive disturbance ) .
A meta- analysis of adjunctive omega-3 versus placebo revealed a significant and moderate to strong effect in favor of omega-3 .
Conversely , a meta- analysis of folic acid revealed a nonsignificant difference from placebo .
Current evidence supports adjunctive use of SAMe , methylfolate , omega-3 , and vitamin D with antidepressants to reduce depressive symptoms
OBJECTIVE There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants .
The adjunctive use of st and ardized pharmaceutical- grade nutrients , known as nutraceuticals , has the potential to modulate several neurochemical pathways implicated in depression .
While many studies have been conducted in this area , to date no specialized systematic review ( or meta- analysis ) has been conducted .
Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones.
BACKGROUND Previous studies of  vitamin C  and kidney stones were conducted mostly in men and either reported disparate results for supplemental and dietary vitamin C or did not examine dietary vitamin C. STUDY DESIGN Prospect i ve cohort analysis . SETTING & PARTICIPANTS 156,735 women in the Nurses ' Health Study ( NHS ) I and II and 40,536 men in the Health Professionals Follow-up Study ( HPFS ) . PREDICTOR  Total , dietary , and supplemental vitamin C intake  , adjusted for age , body mass index , thiazide use , and dietary factors . OUTCOMES Incident kidney stones . RESULTS During a median follow-up of 11.3 to 11.7 years , 6,245 incident kidney stones were identified . After multivariable adjustment ,  total vitamin C intake ( < 90 [ reference ] , 90 - 249 , 250 - 499 , 500 - 999 , and ≥1,000mg/d ) was not significantly associated with risk for kidney stones among women , but was among men ( HRs of 1.00 [ reference ] , 1.19 [ 95 % CI , 0.99 - 1.46 ] , 1.15 [ 95 % CI , 0.93 - 1.42 ] , 1.29 [ 95 % CI , 1.04 - 1.60 ] , and 1.43 [ 95 % CI , 1.15 - 1.79 ] , respectively ; P for trend = 0.005 ) . Median total vitamin C intake for the 500- to 999-mg/d category was ∼700mg/d . Supplemental vitamin C intake ( no use [ reference ] , < 500 , 500 - 999 , and ≥1,000mg/d ) was not significantly associated with risk for kidney stones among women , but was among men ( HR , 1.19 [ 95 % CI , 1.01 - 1.40 ] for ≥1,000mg/d ; P for trend =  0.001 ) . Dietary vitamin C intake was not associated with stones among men or women , although few participants had dietary intakes > 700mg/d . LIMITATIONS Nutrient intakes derived from food-frequency question naires , lack of data on stone composition for all cases . CONCLUSIONS Total and supplemental vitamin C intake was significantly associated with higher risk for incident kidney stones in men , but not in women
Mixed results were found for zinc , folic acid , vitamin C , and tryptophan , with nonsignificant results for inositol .
No major adverse effects were noted in the studies ( aside from minor digestive disturbance ) .
A meta- analysis of adjunctive omega-3 versus placebo revealed a significant and moderate to strong effect in favor of omega-3 .
Conversely , a meta- analysis of folic acid revealed a nonsignificant difference from placebo .
Current evidence supports adjunctive use of SAMe , methylfolate , omega-3 , and vitamin D with antidepressants to reduce depressive symptoms
OBJECTIVE There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants .
The adjunctive use of st and ardized pharmaceutical- grade nutrients , known as nutraceuticals , has the potential to modulate several neurochemical pathways implicated in depression .
While many studies have been conducted in this area , to date no specialized systematic review ( or meta- analysis ) has been conducted .