Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .
Increased sulfate as an etiological factor in the hypercalciuria associated with total parenteral nutrition.
Hypercalciuria and osteopenic bone disease have been identified in many of the patients maintained on long-term total parenteral nutrition ( TPN )  , but the causes ofthe disturbance in calcium balance have not yet been determined . We suggest that the increased sulfate burden experienced when TPN is instituted may be one of those causes . We found substantially increased sulfur amino acid and inorganic sulfate ( 42 to 54 moh/l00 ml of total sulfur ) contents in a commercially available amino acid solution . Administration of TPN to a group of premature newborns result ed in elevated serum sulfate Ifrom 408 ± 54 � amol/l ( mean ± SE , n = 7 ) to 731 ± 99 amol/l ( n = 4 ) ) and increased calcium excretion ( from 26 ± 17 to 86 ± 13 amoh/kg body weight per day ) . Supplemental cysteine ( 0.5 mmol/kg/day ) provoked a further increase in serum sulfate ( 1182 ± 168 � amol/l , n = 9 ) and urinary calcium excretion ( 158 ± 64 � amol/kg/day).In a group of eight infants receiving both TPN and TPN + cysteine , sulfate excretion increased from 1113 ± 106 to 1584 ± 75 � amol/kg/day , while calcium loss increased from 149 ± 40 to 252 ± 26 � amol/kg/day . The possible association of hypersulfatemia , hypercalciuria , and TPN-associated bone disease merits further attention . Am J Clin Nutr l983;37:l08-l13
Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .