Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .
Short-term changes in calcium but not protein intake alter the rate of bone resorption in healthy subjects as assessed by urinary pyridinium cross-link excretion.
This study was conducted to determine whether the markers of bone resorption , pyridinium cross-links of collagen , are sensitive to changes in dietary protein and calcium intake . Fifteen young healthy subjects ( 7 males and 8 females ) participated in three 5-d diet periods . Dietary intake during each dietary period consisted of : 1 ) low nitrogen and low calcium [ 0.49 + /- 0.11 g protein/ ( kg.d ) , 429 + /- 190 mg calcium/d ] ; 2 ) low nitrogen and high calcium [ 0.44 + /- 0.08 g protein/(kg.d ) , 1643 + /- 171 mg calcium/d ] ; and 3 ) a high nitrogen and high calcium [ 2.71 + /- 0.75 g protein/(kg.d ) , 1589 + /- 633 mg calcium/d ] diet , and this was compared with subjects ' baseline dietary intake [ 0.99 + /- 0.51 g protein/(kg.d ) , 589 + /- 152 mg calcium/d ] . The order of these diets was r and omly assigned . Twenty-four-hour and 3-h urine sample s were collected before and during each dietary period and were analyzed for pyridinium cross-links ( pyridinoline , deoxypyridinoline ) , nitrogen and creatinine . The rate of pyrdinium cross-link excretion did not vary with protein intake but was approximately 33 % lower ( P < 0.01 ) during periods of high compared with low calcium intake . These data indicate that a short-term increase in calcium intake is accompanied by a reduced rate of bone resorption and that this effect is independent of dietary protein intake
Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .