There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later childhood: follow up of a randomised controlled trial
Abstract Objective : To determine whether supplementation of infant formula milk with long chain polyunsaturated fatty acids ( LCPUFAs ) influences blood pressure  in later childhood . Design : Follow up of a multicentre , r and omised controlled trial . Setting : Four study centres in Europe . Participants : 147 formula fed children , with a reference group of 88 breastfed children . Intervention : In the original trial newborn infants were r and omised to be fed with a formula supplemented with LCPUFAs ( n=111 ) or a formula without LCPUFAs but otherwise nutritionally similar ( n=126 ) . In the present follow up study the blood pressure of the children at age 6 years was measured . Main outcome measures : Systolic , diastolic , and mean blood pressure . Results : 71 children in the  LCPUFA supplementation group ( 64 % of the original group ) and 76 children in the non-supplementation group ( 60 % ) were enrolled into the follow up study . The LCPUFA group had significantly lower mean blood pressure ( mean difference −3.0 mm Hg ( 95 % confidence interval −5.4 mm Hg to −0.5 mm Hg ) ) and diastolic blood pressure ( mean difference −3.6 mm Hg ( −6.5 mm Hg to −0.6 mm Hg ) ) than the non-supplementation group . The diastolic pressure of the breastfed children ( n=88 ( 63 % ) ) was significantly lower than that of the non-supplemented formula group but did not differ from the LCPUFA formula group . Conclusions : Dietary supplementation with LCPUFAs during infancy is associated with lower blood pressure in later childhood . Blood pressure tends to track from childhood into adult life , so early exposure to dietary LCPUFAs may reduce cardiovascular risk in adulthood . What is already known on this topic Breast milk contains long chain polyunsaturated fatty acids , and breastfed children have lower blood pressure than children fed with formula milk Blood pressure differences in childhood are known to carry through into adulthood Dietary omega 3 fatty acid supplementation can lower blood pressure in adults with hypertension What this paper adds Supplementation with long chain polyunsaturated fatty acids in infancy results in lower blood pressure later in
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .