Combination therapy studies of third-line treatments were rare and centered on medication with PTNS .
Combination therapy , with certain first , second , and third-line OAB therapies , appears to be efficacious .
AIMS Overactive bladder ( OAB ) affects over 17 % of the population and significantly effect the health-related quality of life .
The treatments for OAB include first line ( lifestyle modification , pelvic floor muscle training ) , second line ( anticholinergic or beta-3 agonist medications ) , and third line therapies ( intradetrusor botulinum toxin injection , sacral neurostimulation [ SNM ] , or percutaneous tibial nerve stimulation [ PTNS ] ) .
For those with urinary incontinence secondary to OAB , complete continence is the goal of therapy , though cure rates are only 5 % to 40 % .
The use of combination therapies can be employed in refractory OAB , however , the efficacy of pooled modalities is relatively unknown .
Our objective was to determine the volume of data supporting combination therapy in treating OAB .
Effect of Desmopressin with Anticholinergics in Female Patients with Overactive Bladder
Purpose The aim of this study was to evaluate the effect of desmopressin combined with anticholinergics on daytime frequency and urgency in female patients with overactive bladder ( OAB ) . Material s and Methods We included 68 female patients with OAB . Patients were r and omly assigned to receive 5 mg of solifenacin ( group I ) or 5 mg of solifenacin and 0.2 mg of desmopressin ( group II ) for 2 weeks . A pre/post-treatment 3-day voiding diary and the Urinary Distress Inventory ( UDI-6 ) and Incontinence Impact Question naire ( IIQ-7 ) were used to assess changes in voiding symptoms and quality of life ( QoL ) ; results were compared between the two groups . Results Groups I and II included 31 and 37 patients , respectively . Time to first void was 12 min later in group II ( 105 min vs. 117 min ) , but this difference was not statistically significant . However , time to the second and third voids ( 203 min vs. 255 min , 312 min vs. 368 min ) and the first urgency episode ( 212 min vs. 255 min ) were significantly longer in group II . Compared with group I , patients in group II showed significant improvement in QoL scores . When improvement after treatment was defined as increase in time to first void of greater than 10 % after 2 weeks of treatment , desmopressin with anticholinergics was more effective in patients over the age of 65 years and with more than 150 ml of voided volume . Conclusions Desmopressin combined with anticholinergics was more effective than anticholinergics only in the treatment of female patients with OAB
Combination therapy studies of third-line treatments were rare and centered on medication with PTNS .
Combination therapy , with certain first , second , and third-line OAB therapies , appears to be efficacious .
AIMS Overactive bladder ( OAB ) affects over 17 % of the population and significantly effect the health-related quality of life .
The treatments for OAB include first line ( lifestyle modification , pelvic floor muscle training ) , second line ( anticholinergic or beta-3 agonist medications ) , and third line therapies ( intradetrusor botulinum toxin injection , sacral neurostimulation [ SNM ] , or percutaneous tibial nerve stimulation [ PTNS ] ) .
For those with urinary incontinence secondary to OAB , complete continence is the goal of therapy , though cure rates are only 5 % to 40 % .
The use of combination therapies can be employed in refractory OAB , however , the efficacy of pooled modalities is relatively unknown .
Our objective was to determine the volume of data supporting combination therapy in treating OAB .