There was no significant change in the γGT levels .
Significant differences were not found .
CONCLUSION Silymarin minimally reduced , but without clinical relevance , the serum levels of ALT and AST .
AIM To evaluate the effect of silymarin on the serum levels of alanine aminotransferase ( ALT ) , aspartate aminotransferase ( AST ) and gamma glutamyl transpeptidase ( γGT ) in patients with liver diseases .
Therapeutic effects of restricted diet and exercise in obese patients with fatty liver.
BACKGROUND / AIMS The incidence of obese patients with fatty liver has recently increased in Japan as well as in the United States and Europe . Fatty liver may occasionally progress to liver cirrhosis . In this study , we have compared the effects of restricted diet and exercise versus no treatment in obese patients with fatty liver . METHODS Twenty-five obese patients with fatty liver were divided into treated and control groups . Fifteen obese patients followed a program of restricted diet ( ideal weight x 25 Cal x kg(-1 ) ) and exercise ( walking or jogging ) for a trial period of 3 months . No changes in diet or lifestyle were made by the other 10 patients during the same trial period . Blood biochemical tests and liver histology were compared in all patients before and after the trial . RESULTS In the treated group , weight , blood biochemical data such as aminotransferase , albumin , cholinesterase , total cholesterol and fasting blood glucose values , and steatosis were significantly decreased after the trial . In the control group , there were no significant differences in the clinical and histological findings before and after the trial . CONCLUSIONS These results indicate that restricted diet and exercise therapy , such as walking and jogging , are useful means of improving blood biochemical data and histological findings in liver tissues related to fatty liver
There was no significant change in the γGT levels .
Significant differences were not found .
CONCLUSION Silymarin minimally reduced , but without clinical relevance , the serum levels of ALT and AST .
AIM To evaluate the effect of silymarin on the serum levels of alanine aminotransferase ( ALT ) , aspartate aminotransferase ( AST ) and gamma glutamyl transpeptidase ( γGT ) in patients with liver diseases .