No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .
Comparison of the efficacy of topical N-acetyl-cysteine and a topical steroid-antibiotic combination therapy in the treatment of meibomian gland dysfunction.
PURPOSE This study aim ed to compare the efficacy of topical N-acetyl-cysteine ( NAC ) with a topical steroid-antibiotic combination , betamethasone-sulfacetamide sodium therapy in patients with meibomian gl and dysfunction ( MGD ) . METHODS Twenty patients with MGD were prospect ively r and omized and assigned into 2 groups . The patients were instructed to use either NAC 5 % or a topical steroid-antibiotic combination , betamethasone 0.1%-sulfacetamide sodium 10 % , topically 4 times a day for a month . All patients were instructed to apply lid hygiene once daily . RESULTS One month of topical therapy provided statistically significant improvements in fluorescein break-up time and Schirmer scores as compared with the initial study visit in both groups ( P≤0.001 ) . Significant improvements for the symptoms of ocular burning , itching , and intermittent filmy or blurred vision were noted in both groups at 1 month as compared with 1 day ( P<0.05 ) . Considering these rates , there was no significant difference between the groups ( P>0.05 ) . None of the patients developed an allergic reaction to the medications , and intraocular pressure measurements were within the normal limits in both groups . CONCLUSION When used in conjunction with eyelid hygiene , topical administration of NAC appears to be as effective as a topical steroid-antibiotic combination , betamethasone-sulfacetamide sodium therapy in patients with MGD
No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .