Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .
The effectiveness of transdermal electromotive administration with verapamil and dexamethasone in the treatment of Peyronie’s disease
Aim To determine the effectiveness of transdermal electromotive administration ( TEA ) of verapamil and dexamethasone in the treatment of Peyronie ’s disease ( PD ) . Method Totally , 51 patients with PD were prospect ively included in the study . All patients were evaluated by history , subjective score scales , physical examination , photographs , and penile USG , before and after therapy . All patients were treated with TEA of the combination of verapamil and dexamethasone . The treatment plan included a total of 20 sessions ( at 3-day intervals for a period of 2 months ) , each with a duration of 20 min . At the end of the study , improvements in penile plaques , penile deviation , pain on erection , and erectile dysfunction were determined . Results The findings in 41 of the 51 patients were eligible to present . Median patient age was 52 years . Median duration of disease at presentation was 8 months . Remarkable reduction in palpable plaques and in penile angulation was observed in 10 patients ( 24 % ) and 11 ( 26 % ) patients , respectively . There were significant decreases in median plaque volume from 72 mm2 to 45 mm2 ( P < 0.001 ) , and in median penile angulation from 25º to 15º ( P < 0.001 ) . Impaired sexual activity and pain on erection had completely resolved in 11 ( 55 % ) patients and in 16 ( 80 % ) , respectively . Conclusion The results of our study have shown that TEA of the combination of verapamil and dexamethasone is a more effective therapy for improving subjective symptoms rather than objective symptoms . Therefore , we think that this treatment can be individualized according to the clinical features of PD patients
Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .