This meta- analysis concludes that l-arginine supplementation can significantly reduce blood TAG levels ; however , there is insufficient evidence to support its hypocholesterolaemic effects .
A number of clinical trials have examined the effect of l-arginine on lipid profile in recent years ; however , the results remain equivocal .
Therefore , the present study aims to summarise and quantitatively examine the available evidence on the effectiveness l-arginine supplementation on lipid parameters using a systematic review and meta-analytic approach .
Changes in mineral status are associated with improvements in insulin sensitivity in obese patients following l-arginine supplementation
Purpose The aim of this study is to evaluate the long-term influence of l-arginine intake on mineral concentration in patients with obesity and to assess the changes in lipid serum levels , fat content , and insulin resistance that result . Methods A r and omized double-blind placebo-controlled study was conducted . 88 obese patients were r and omly assigned to receive either 9 g of l-arginine or placebo daily , for 6 months . At baseline and after 6 months , selected anthropometrical measurements and blood biochemical analyses were performed and mineral levels were assessed . To assess insulin sensitivity , the gold-st and ard euglycemic clamp methodology was used . Results We found that 6 months of l-arginine supplementation result ed in significant increases in insulin sensitivity ( Δ1.1 mg/kg/min , P < 0.01 ) and zinc levels ( Δ1.5 μmol/L , P < 0.001 ) . Moreover , a positive correlation between the change in zinc concentration in serum and the change in insulin sensitivity was observed ( R = 0.80 , P < 0.01 ) . In the group of patients treated with l-arginine , a negative correlation between the change in zinc concentration in serum and the change in body fat content was noted ( R = −0.38 , P < 0.05 ) . Conclusions l-Arginine supplementation affects zinc status in obese patients . One beneficial influence is related to the improvements in insulin sensitivity
This meta- analysis concludes that l-arginine supplementation can significantly reduce blood TAG levels ; however , there is insufficient evidence to support its hypocholesterolaemic effects .
A number of clinical trials have examined the effect of l-arginine on lipid profile in recent years ; however , the results remain equivocal .
Therefore , the present study aims to summarise and quantitatively examine the available evidence on the effectiveness l-arginine supplementation on lipid parameters using a systematic review and meta-analytic approach .