Overall , the current meta- analysis demonstrated that ALA administration may lead to an improvement in glucose homeostasis parameters and lipid profiles except HDL-cholesterol levels
OBJECTIVE This systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was performed to summarize the effect of alpha-lipoic acid ( ALA ) supplementation on glycemic control and lipid profiles among patients with metabolic diseases .
α-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction.
OBJECTIVE This study aims to evaluate the efficacy and safety of α-lipoic acid in the treatment of aged type 2 diabetes mellitus ( T2DM ) complicated with acute cerebral infa rct ion . PATIENTS AND METHODS 90 patients were r and omly divided into two groups , on the basis of conventional treatment . The experiment group was administrated with α-lipoic acid , while only Vitamin C for the control group , for 3 consecutive weeks . Before and after the experiment , superoxide dismutase ( SOD ) , glutathione peroxidase ( GSH-Px ) and malondialdehyde ( MDA ) levels were measured and scored with the NIHSS ( National Institutes of Health Stroke Scale ) , and the changes of blood glucose , insulin function and other indicators were observed . RESULTS After the treatment , the plasma SOD and GSH-Px levels increased , while MDA decreased ( p < 0.05 ) , with statistical significance when compared with the control group ( p < 0.01 ) . NIHSS score , blood glucose , blood lipids and HOMA-IA of the experiment group decreased significantly ( p < 0.01 ) ; and no significant adverse reactions were found in both groups . CONCLUSIONS α-lipoic acid was safe and effective in the treatment of aged T2DM complicated with acute cerebral infa rct ion , significantly reducing the patient 's oxidative stress , blood glucose and lipid levels and being able to improve islet function
Overall , the current meta- analysis demonstrated that ALA administration may lead to an improvement in glucose homeostasis parameters and lipid profiles except HDL-cholesterol levels
OBJECTIVE This systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was performed to summarize the effect of alpha-lipoic acid ( ALA ) supplementation on glycemic control and lipid profiles among patients with metabolic diseases .