Based on moderate quality evidence , due to concerns about risk of bias and imprecision , initiation of statin therapy within 14 days following ACS does not reduce death , myocardial infa rct ion , or stroke up to four months , but reduces the occurrence of unstable angina at four months following ACS .
Serious side effects were rare
BACKGROUND The early period following the onset of acute coronary syndrome ( ACS ) represents a critical stage of coronary heart disease , with a high risk of recurrent events and deaths .
The short-term effects of early treatment with statins on patient-relevant outcomes in patients suffering from ACS are unclear .
This is an up date of a review previously published in 2011 .
OBJECTIVES To assess the effects , both harms and benefits , of early administered statins in patients with ACS , in terms of mortality and cardiovascular events .
Intensive statin therapy for Chinese patients with coronary artery disease undergoing percutaneous coronary intervention (ISCAP study)
Background : Myocardial necrosis is related to higher incidence of cardiovascular events and higher mortality rates during follow‐up . Statins have been demonstrated to lower the risk of periprocedural myocardial infa rct ion . The aim of this study is to evaluate the safety and efficacy of intensive statin therapy and the long‐term outcome of patients in the Asian population . Study design : Approximately 1,100 patients with stable angina or non‐ST elevation acute coronary syndrome undergoing selective percutaneous coronary intervention ( PCI ) are enrolled in this study . Patients are r and omized either to the experimental group ( 80 mg atorvastatin 80 mg/day × 2 days before and 40 mg/day × 30 days after PCI ) or to the control group ( usual care ) . Creatine kinase‐MB ( CK‐MB ) , troponin I ( cTnI ) , and serum creatine are measured at 24 hours after the procedure . The total follow‐up period is 6 months . The primary objective is to evaluate the efficacy  of intensive atorvastatin treatment compared with usual care in reducing 30‐day primary cardiovascular endpoints in patients undergoing selective PCI . Secondary endpoints are changes in myocardial biomarkers ( cTnI , CK‐MB ) and hs‐CRP , CIN morbidity , 6‐month clinical outcomes , and safety . Conclusion : The result of the ISCAP study will provide important evidence on the efficacy and safety of periprocedural serial intensive statin treatment in Asian patients with coronary artery disease undergoing selective PCI . © 2011 Wiley Periodicals ,
Based on moderate quality evidence , due to concerns about risk of bias and imprecision , initiation of statin therapy within 14 days following ACS does not reduce death , myocardial infa rct ion , or stroke up to four months , but reduces the occurrence of unstable angina at four months following ACS .
Serious side effects were rare
BACKGROUND The early period following the onset of acute coronary syndrome ( ACS ) represents a critical stage of coronary heart disease , with a high risk of recurrent events and deaths .
The short-term effects of early treatment with statins on patient-relevant outcomes in patients suffering from ACS are unclear .
This is an up date of a review previously published in 2011 .
OBJECTIVES To assess the effects , both harms and benefits , of early administered statins in patients with ACS , in terms of mortality and cardiovascular events .