RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .
The efficacy of telmisartan compared with perindopril in patients with mild-to-moderate hypertension.
In this study , efficacy of the angiotensin II type 1 receptor blocker telmisartan given as monotherapy was compared with that of perindopril monotherapy in patients with mild-to-moderate hypertension . After a 2-week , single-blind , placebo run-in period , 60 patients were r and omised to double-blind , once-daily treatment with telmisartan 80 mg or perindopril 4 mg for 6 weeks . Clinic and ambulatory blood pressure measurements and clinical laboratory evaluation were performed at the end of the placebo run-in and active treatment phases . Both telmisartan and perindopril significantly ( p < 0.0001 ) reduced clinic systolic blood pressure ( SBP ) and diastolic blood pressure ( DBP ) compared with baseline values . Also , both drugs significantly ( p < 0.0001 ) reduced 24-h mean ambulatory SBP and DBP compared with baseline . Comparison of the mean hourly antihypertensive activities showed that the reduction in mean ambulatory DBP for the last 8 h of the dosing interval was significantly greater ( p < 0.05 ) in telmisartan-treated patients . A 24-h mean DBP of < 85 mmHg was observed in 66.6 % of the telmisartan-treated patients but in only 46.6 % of the perindopril-treated patients ( p < 0.05 ) . It is concluded that telmisartan and perindopril both produce significant reductions in clinic SBP and DBP , but the mean reduction in ambulatory DBP during the last 8 h of the dosing interval is greater in patients treated with telmisartan
RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .