Preliminary work from this review suggests that exercise intervention compared with usual care both pre and post-surgery is associated with improved cardiopulmonary exercise capacity , increased muscle strength and reduced fatigue , post-operative complications and hospital length of stay .
BACKGROUND Surgery remains the best curative option for appropriately selected patients with lung cancer .
Evidence suggests that improving cardiovascular fitness and functional capacity can accelerate post-surgery recovery and reduce mortality .
However , the effect of exercise intervention for patients surgically treated for Non-Small Cell Lung Cancer [ NCSLC ] has not been fully examined .
PURPOSE This review examines the literature regarding exercise intervention for patients who are surgically treated for NSCLC focussing on three key areas : method ological quality , intervention design ( e.g. duration , frequency , type ) and outcomes measured .
Effects of presurgical exercise training on systemic inflammatory markers among patients with malignant lung lesions.
Systemic inflammation plays an important role in the initiation , promotion , and progression of lung carcinogenesis . The effects of interventions to lower inflammation have not been explored . Accordingly , we conducted a pilot study to explore the effects of exercise training on changes in biomarkers of systemic inflammation among patients with malignant lung lesions . Using a single-group design , 12 patients with suspected operable lung cancer were provided with structured exercise training until surgical resection . Participants underwent cardiopulmonary exercise testing , 6 min walk testing , pulmonary function testing , and blood collection at baseline and immediately prior to surgical resection . Systemic inflammatory markers included intracellular adhesion molecule (ICAM)-1 , macrophage inflammatory protein-1alpha , interleukin (IL)-6 , IL-8 , monocyte chemotactic protein-1 , C-reactive protein , and tumor necrosis factor-alpha . The overall exercise adherence rate was 78 % , with patients completing a mean of 30 + /- 25 sessions . Mean peak oxygen consumption increased 2.9 mL.kg-1.min-1 from baseline to presurgery ( p = 0.016 ) . Results indicate that exercise training result ed in a significant reduction in ICAM-1 ( p = 0.041 ) . Changes in other inflammatory markers did not reach statistical significance . Change in cardiorespiratory fitness was not associated with change in systemic inflammatory markers . This exploratory study provides an initial step for future studies to eluci date the potential role of exercise , as well as identify the underlying mechanisms of action , as a means of modulating the relationship between inflammation and cancer pathogenesis
Preliminary work from this review suggests that exercise intervention compared with usual care both pre and post-surgery is associated with improved cardiopulmonary exercise capacity , increased muscle strength and reduced fatigue , post-operative complications and hospital length of stay .
BACKGROUND Surgery remains the best curative option for appropriately selected patients with lung cancer .
Evidence suggests that improving cardiovascular fitness and functional capacity can accelerate post-surgery recovery and reduce mortality .
However , the effect of exercise intervention for patients surgically treated for Non-Small Cell Lung Cancer [ NCSLC ] has not been fully examined .
PURPOSE This review examines the literature regarding exercise intervention for patients who are surgically treated for NSCLC focussing on three key areas : method ological quality , intervention design ( e.g. duration , frequency , type ) and outcomes measured .