: Probiotic supplementation reduces the risk of LOS in preterm infants
CONTEXT : Late-onset sepsis ( LOS ) is a major cause of mortality and morbidity in preterm infants .
Despite various preventive measures , its incidence continues to remain high , hence the urgent need for additional approaches .
One such potential strategy is supplementation with probiotics .
Currently there are > 30 r and omized controlled trials ( RCTs ) of probiotics in preterm infants that have reported on LOS .
A high burden of late-onset sepsis among newborns admitted to the largest neonatal unit in central Vietnam
Objective : The objective of this study is to determine the prevalence , causes and outcome of sepsis in hospitalized neonates in the largest neonatal unit in central Vietnam . Study Design : A 1-year prospect i ve cohort study of newborns admitted to the neonatal unit in Da Nang . A sepsis work-up including blood culture was undertaken before commencing antibiotics for neonates with suspected sepsis . Result : Of 2555 neonatal admissions , 616 neonates had 729 episodes of suspected invasive sepsis . A pathogen was isolated from blood in 115 ( 16 % ) episodes in 106 neonates . The prevalence of early-onset sepsis ( EOS ) was 8 ( 95 % confidence interval ( CI ) : 4 to 11 ) per 1000 admissions , and of late-onset sepsis ( LOS ) was 34 ( 95 % CI : 27 to 41 ) per 1000 admissions . Of 86 neonates with LOS , 69 ( 80 % ) also fulfilled the criteria for nosocomial sepsis . The commonest bacterial causes of EOS were coagulase-negative Staphylococcus ( CoNS ) and Staphylococcus aureus , and of LOS were Acinetobacter , CoNS and Klebsiella pneumoniae . Fungal sepsis occurred in 35 neonates of which most were nosocomial sepsis . In vitro resistance to multiple antibiotics was common among Gram-negative bacteria . Antibiotics were prescribed and given to 68 % of all admissions , and 14 % of all admissions received four or more different antibiotics . The case fatality rate for confirmed sepsis was 46 % . Conclusion : Late-onset , nosocomial sepsis was common and associated with a high mortality in hospitalized newborns in the largest neonatal unit in central Vietnam . These findings highlighted the need for improved infection control measures and antibiotic stewardship , which have since been implemented
: Probiotic supplementation reduces the risk of LOS in preterm infants
CONTEXT : Late-onset sepsis ( LOS ) is a major cause of mortality and morbidity in preterm infants .
Despite various preventive measures , its incidence continues to remain high , hence the urgent need for additional approaches .
One such potential strategy is supplementation with probiotics .
Currently there are > 30 r and omized controlled trials ( RCTs ) of probiotics in preterm infants that have reported on LOS .