Conclusions Short-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders
Background Fish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases , such as cardiovascular disease , type 2 diabetes and several types of cancers .
However , the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial .
This meta- analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aim ed to evaluate whether fish oil supplementation could improve insulin sensitivity .
Eicosapentaenoic acid improves insulin sensitivity and blood sugar in overweight type 2 diabetes mellitus patients: a double-blind randomised clinical trial.
INTRODUCTION Diabetes mellitus is the most common metabolic disorder in humans , and its incidence is increasing rapidly worldwide . Although polyunsaturated fatty acids have beneficial effects on diabetes mellitus , previous data regarding the possible positive effects of n-3 fatty acids on glycaemic indices were inconclusive . We conducted a double-blind r and omised clinical trial to determine the effects of eicosapentaenoic acid ( EPA ) , an n-3 polyunsaturated fatty acid , on overweight patients with type 2 diabetes mellitus ( T2DM ) . METHODS This double-blind , placebo-controlled r and omised clinical trial was conducted on a total of 67 overweight patients with T2DM for a duration of three months . Of these 67 patients , 32 received 2 g purified EPA daily , while 35 received a placebo of 2 g corn oil daily . The patients ' fasting plasma glucose ( FPG ) , serum insulin , glycated haemoglobin ( HbA1c ) and insulin sensitivity indices were assessed . RESULTS After three months of EPA supplementation , the group that received EPA showed significant decreases in FPG ( p < 0.001 ) , HbA1c ( p = 0.01 ) and homeostasis model assessment of insulin resistance ( HOMA-IR ) ( p = 0.032 ) , when compared to the placebo group . EPA supplementation result ed in decreased serum insulin levels , with the levels between the EPA and placebo groups showing a significant difference ( p = 0.004 ) . CONCLUSION The results of our study indicate that EPA supplementation could improve insulin sensitivity . It was able to decrease serum insulin , FPG , HbA1c and HOMA-IR .  EPA could have beneficial effects on glycaemic indices in patients with T2DM
Conclusions Short-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders
Background Fish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases , such as cardiovascular disease , type 2 diabetes and several types of cancers .
However , the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial .
This meta- analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aim ed to evaluate whether fish oil supplementation could improve insulin sensitivity .