For height outcome , articles were limited to studies reporting adult height and to systematic review s. FINDINGS Recombinant human growth hormone therapy of children with idiopathic short stature increases height in some children .
The cost-benefit ratio is controversial .
AND RELEVANCE Growth hormone treatment may be considered in some children with idiopathic short stature
IMPORTANCE Approximately 2 % of children are defined as having short stature .
Deciding when to pursue recombinant human growth hormone therapy to increase adult height is controversial .
OBJECTIVE To review the management of children with idiopathic short stature , including diagnostic evaluation and therapeutic options .
Laboratory Values for Children With Newly Diagnosed Inflammatory Bowel Disease
OBJECTIVE . The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease . METHODS . Data were obtained from a registry of children with newly diagnosed inflammatory bowel disease who were enrolled prospect ively in 18 US/Canadian centers . Laboratory values investigated included hemoglobin level , platelet count , albumin level , and erythrocyte sedimentation rate . Disease severity was categorized by physician global assessment . RESULTS . A total of 526 children ( mean age : 11.6 years ; 58 % male ; 392 with Crohn disease and 134 with ulcerative colitis ) were studied . All 4 values were normal for 21 % of patients with mild Crohn disease and 54 % with mild ulcerative colitis . In contrast , only 3.8 % of children with moderate/severe Crohn disease and 4.3 % with moderate/severe ulcerative colitis had normal results for all 4 tests . The erythrocyte sedimentation rate was least likely to be normal ; overall , 26 % of patients with inflammatory bowel disease had a normal erythrocyte sedimentation rate , including 18 % with moderate/severe disease . Hemoglobin levels were normal for 32 % , platelet counts for 50 % , and albumin levels for 60 % . There was no clear association between Crohn disease location and either severity or number of normal laboratory values . In contrast , there were direct correlations between ulcerative colitis disease severity and both the extent of bowel inflammation and the number of abnormal laboratory tests . CONCLUSION . The presence of normal screening laboratory studies should not dissuade clinicians from considering a diagnosis of inflammatory bowel disease
For height outcome , articles were limited to studies reporting adult height and to systematic review s. FINDINGS Recombinant human growth hormone therapy of children with idiopathic short stature increases height in some children .
The cost-benefit ratio is controversial .
AND RELEVANCE Growth hormone treatment may be considered in some children with idiopathic short stature
IMPORTANCE Approximately 2 % of children are defined as having short stature .
Deciding when to pursue recombinant human growth hormone therapy to increase adult height is controversial .
OBJECTIVE To review the management of children with idiopathic short stature , including diagnostic evaluation and therapeutic options .