Quantitative relations between baseline iron status , study duration , and iron dose on changes in iron-status biomarkers , which were generated from the meta-analyses , can be used to predict effects of trials of iron supplementation and fortification and to design iron-intervention programs
BACKGROUND The response of status biomarkers to an increase in iron supply depends on several physiologic and environmental factors , which make it difficult to predict the outcome of an intervention .
OBJECTIVE We assessed effects of baseline iron status , sex , menopausal status , duration of intervention , iron form , and daily dose on the change in iron status in response to iron supplementation .
Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women.
Fe-deficiency anaemia is a worldwide health problem . We studied the influence of consuming an Fe-fortified fruit juice on Fe status in menstruating women . A r and omised , double-blind , placebo-controlled study of 16 weeks of duration was performed . Subjects were r and omised into two groups : the P group ( n 58 ) or the F group ( n 64 ) , and consumed , as a supplement to their usual diet , 500 ml/d of a placebo fruit juice or an Fe-fortified fruit juice , respectively . The Fe-fortified fruit juice , containing microencapsulated iron pyrophosphate , provided 18 mg Fe/d ( 100 % of the RDA ) . At baseline and monthly , dietary intake , body weight and Fe parameters were determined : total erythrocytes , haematocrit , mean corpuscular volume ( MCV ) , red blood cell distribution width ( RDW ) , Hb , serum Fe , serum ferritin , serum transferrin , transferrin saturation , soluble transferrin receptor ( sTfR ) and zinc protoporphyrin ( ZnPP ) . The fruit juice consumption involved increased intake of carbohydrates and vitamin C , and increased BMI within normal limits . Ferritin was higher in the F group after week 4 ( P < 0·05 ) and became 80 % higher than in the P group after week 16 ( P < 0·001 ) , and transferrin decreased in the F group compared with the P group after week 4 ( P < 0·001 ) . RDW was higher at weeks 4 and 8 in the F group compared with the P group ( P < 0·05 ) . Transferrin saturation increased after week 8 , and haematocrit , MCV and Hb increased after week 12 , in the F group compared with the P group . Serum Fe did not change . sTfR and ZnPP decreased in the F group at week 16 ( P < 0·05 ) . Iron pyrophosphate-fortified fruit juice improves Fe status and may be used to prevent Fe-deficiency anaemia
Quantitative relations between baseline iron status , study duration , and iron dose on changes in iron-status biomarkers , which were generated from the meta-analyses , can be used to predict effects of trials of iron supplementation and fortification and to design iron-intervention programs
BACKGROUND The response of status biomarkers to an increase in iron supply depends on several physiologic and environmental factors , which make it difficult to predict the outcome of an intervention .
OBJECTIVE We assessed effects of baseline iron status , sex , menopausal status , duration of intervention , iron form , and daily dose on the change in iron status in response to iron supplementation .