In conclusion , Zinc supplementation  has favourable effects on plasma lipid parameters .
Zinc supplementation  significantly reduced total cholesterol , LDL cholesterol and triglycerides .
Therefore it may have the potential to reduce the incidence of atherosclerosis related morbidity and mortality
Zinc is a mineral that plays a vital role in many biological processes and plays an important role in insulin action and carbohydrate metabolism .
It may also have a protective role in the prevention of atherogenesis .
Numerous studies have evaluated the effects of Zinc supplementation on serum lipids in humans and have demonstrated varying results .
We systematic ally evaluated the literature and performed a meta- analysis on the effects of Zinc supplementation on serum lipids .
Paraoxonase Enzyme Activity Is Enhanced by Zinc Supplementation in Hemodialysis Patients
Background and Aims : Patients on maintenance hemodialysis ( HD ) face an increased risk of atherosclerosis , a crucial problem and the leading cause of cardiovascular morbidity and mortality . This study was design ed to evaluate the effects of zinc supplementation on paraoxonase ( PON ) enzyme activity in patients on HD . Methods : This double-blind r and omized controlled trial was conducted from June 2005 to June 2007 . Sixty HD patients were enrolled and divided into two groups : treatment ( case ) and control . The treatment and control groups were treated with 100 mg/day zinc or placebo , respectively , for 2 months . Serum zinc concentration was measured by atomic absorption spectrophotometry . PON activity  was evaluated by spectrophotometric method . Lipid profile  was determined using commercial kits , and apolipoprotein AI ( Apo-AI ) and B ( Apo-B ) levels were measured by commercial immunoturbidimetric kits . Results : In the case group , there was no significant change in the serum total cholesterol ( TC ) , triglyceride ( TG ) , low-density lipoprotein ( LDL ) , and Apo-B levels , while the serum levels of high-density lipoprotein ( HDL ) , Apo-AI , and PON activity were significantly increased ( p = 0.02 ) . In the control group , although significant increases were observed in the serum levels of TC , TG , and Apo-B ( p = 0.009 , 0.019 , and 0.001 , respectively ) , the serum PON activity was significantly decreased ( p = 0.025 ) and the serum levels of HDL , LDL , and Apo-AI were not changed . At the end of intervention period , the serum level of Apo-AI and PON activity were significantly higher in the case group . Conclusions : Zinc supplementation increased both the activity of PON and the serum level of Apo-AI in the HD patients
In conclusion , Zinc supplementation  has favourable effects on plasma lipid parameters .
Zinc supplementation  significantly reduced total cholesterol , LDL cholesterol and triglycerides .
Therefore it may have the potential to reduce the incidence of atherosclerosis related morbidity and mortality
Zinc is a mineral that plays a vital role in many biological processes and plays an important role in insulin action and carbohydrate metabolism .
It may also have a protective role in the prevention of atherogenesis .
Numerous studies have evaluated the effects of Zinc supplementation on serum lipids in humans and have demonstrated varying results .
We systematic ally evaluated the literature and performed a meta- analysis on the effects of Zinc supplementation on serum lipids .