Comparison of PO diets with diets rich in stearic acid , monounsaturated fatty acids ( MUFAs ) , and polyunsaturated fatty acids ( PUFAs ) showed significantly higher TC , LDL cholesterol , apolipoprotein B , HDL cholesterol , and apolipoprotein A-I , whereas most of the same biomarkers were significantly lower when compared with diets rich in myristic/lauric acid .
Comparison of PO-rich diets with diets rich in trans fatty acids showed significantly higher concentrations of HDL cholesterol and apolipoprotein A-I and significantly lower apolipoprotein B , triacylglycerols , and TC/HDL cholesterol .
Stratified and meta-regression analyses showed that the higher concentrations of TC and LDL cholesterol , when PO was substituted for MUFAs and PUFAs , were not significant in young people and in subjects with diets with a lower percentage of energy from fat .
Both favorable and unfavorable changes in CHD/CVD risk markers occurred when PO was substituted for the primary dietary fats , whereas only favorable changes occurred when PO was substituted for trans fatty acids .
BACKGROUND Palm oil ( PO ) may be an unhealthy fat because of its high saturated fatty acid content .
OBJECTIVE The objective was to assess the effect of substituting PO for other primary dietary fats on blood lipid-related markers of coronary heart disease ( CHD ) and cardiovascular disease ( CVD ) .
Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans.
The objective of this study was to compare the effects of linoleic acid ( cis , cis-C18:2(n-6 ) ) and its hydrogenation products elaidic ( trans-C18:1(n-9 ) ) and stearic acid ( C18:0 ) on serum lipoprotein levels in humans . Twenty-six men and 30 women , all normolipemic and apparently healthy , completed the trial . Three experimental diets were supplied to every subject for 3 weeks each , in r and om order ( multiple cross-over ) . The Linoleate-diet provided 12.0 % of total energy intake as linoleic acid , 2.8 % as stearic acid , and 0.1 % as trans fatty acids . The Stearate-diet supplied 3.9 energy % as linoleic acid , 11.8 % stearic acid , and 0.3 % trans fatty acids . The Trans-diet provided 3.8 energy % as linoleic acid , 3.0 % stearic acid , and 7.7 % as monounsaturated trans fatty acids , largely elaidic acid ( trans-C18:1(n-9 ) ) . Other nutrients were constant . Fasting blood was sample d at the end of each dietary period . Mean ( + /- SD ) serum LDL cholesterol was 109 + /- 24 mg/dl ( 2.83 + /- 0.63 mmol/l ) on the Linoleate-diet . It rose to 116 + /- 27 mg/dl ( 3.00 + /- 0.71 mmol/l ) on the Stearate-diet ( change , 7 mg/dl or 0.17 mmol/l , P = 0.0008 ) and to 119 + /- 25 mg/dl ( 3.07 + /- 0.65 mmol/l ) on the Trans-diet ( change , 9 mg/dl or 0.24 mmol/l , P less than 0.0001 ) . High density lipoprotein ( HDL ) cholesterol decreased by 2 mg/dl ( 0.06 mmol/l , P less than 0.0001 ) on the Stearate-diet and by 4 mg/dl ( 0.10 mmol/l , P less than 0.0001 ) on the Trans-diet , both relative to linoleic acid . Our findings show that 7.7 % of energy ( mean , 24 g/day ) of trans fatty acids in the diet significantly lowered HDL cholesterol and raised LDL cholesterol relative to linoleic acid . Combination with earlier results ( Mensink , R. P. , and M. B. Katan . 1990 . N. Engl . J. Med . 323 : 439 - 445 ) suggests a linear dose-response relation . Replacement of linoleic acid by stearic acid also caused somewhat lower HDL cholesterol and higher LDL cholesterol levels . Hydrogenation of linoleic acid to either stearic or trans fatty acids produces fatty acids that may increase LDL and decrease HDL cholesterol relative to linoleic acid itself
Comparison of PO diets with diets rich in stearic acid , monounsaturated fatty acids ( MUFAs ) , and polyunsaturated fatty acids ( PUFAs ) showed significantly higher TC , LDL cholesterol , apolipoprotein B , HDL cholesterol , and apolipoprotein A-I , whereas most of the same biomarkers were significantly lower when compared with diets rich in myristic/lauric acid .
Comparison of PO-rich diets with diets rich in trans fatty acids showed significantly higher concentrations of HDL cholesterol and apolipoprotein A-I and significantly lower apolipoprotein B , triacylglycerols , and TC/HDL cholesterol .
Stratified and meta-regression analyses showed that the higher concentrations of TC and LDL cholesterol , when PO was substituted for MUFAs and PUFAs , were not significant in young people and in subjects with diets with a lower percentage of energy from fat .
Both favorable and unfavorable changes in CHD/CVD risk markers occurred when PO was substituted for the primary dietary fats , whereas only favorable changes occurred when PO was substituted for trans fatty acids .
BACKGROUND Palm oil ( PO ) may be an unhealthy fat because of its high saturated fatty acid content .
OBJECTIVE The objective was to assess the effect of substituting PO for other primary dietary fats on blood lipid-related markers of coronary heart disease ( CHD ) and cardiovascular disease ( CVD ) .