The results of meta- analysis showed statistically significant differences between aloe vera and control groups in alleviating pain/burning sensation at the end of the first and second month , in favor of aloe vera , but no significant differences were found at the end of the third month .
With regard to objective clinical outcomes , no statistically significant differences were found between the groups .
Aloe vera has a promising effect in reducing pain/burning sensation and clinical improvement in patients with OSF .
The management of oral submucous fibrosis ( OSF ) is quite challenging , and as yet , no effective therapy is available for its management .
The present systematic review and meta- analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF .
Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis – a clinical study
BACKGROUND Oral submucous fibrosis is a chronic disease , treatment of which has largely been symptomatic . Aloe vera has immunomodulatory , anti-inflammatory , wound healing , antioxidant , and antineoplastic activities . All such properties of aloe vera suggest the possibility of its use in the management of oral submucous fibrosis . METHODS Seventy-four patients of oral submucous fibrosis were r and omly divided into 2 groups . Group A patients were treated with systemic ( juice ) and topical aloe vera ( gel ) for 3 months . Group B patients were treated with intralesional injection of hydrocortisone and hyaluronidase for 6 weeks with antioxidant supplements for 3 months . Patients were assessed for reduction in burning sensation and increase in mouth opening , cheek flexibility , and tongue protrusion at an interval of 1 , 2 , and 3 months . RESULTS Both the groups showed statistically significant improvements in all the study parameters at the end of study period ( P < 0.001 ) . The clinical response to aloe vera was comparable to that of intralesional injections of hydrocortisone and hyaluronidase with antioxidant supplementation . CONCLUSION The study concludes that aloe vera can be an alternative , safe , and effective treatment regime in the management of oral submucous fibrosis . Long-term follow-up studies with larger sample size are recommended
The results of meta- analysis showed statistically significant differences between aloe vera and control groups in alleviating pain/burning sensation at the end of the first and second month , in favor of aloe vera , but no significant differences were found at the end of the third month .
With regard to objective clinical outcomes , no statistically significant differences were found between the groups .
Aloe vera has a promising effect in reducing pain/burning sensation and clinical improvement in patients with OSF .
The management of oral submucous fibrosis ( OSF ) is quite challenging , and as yet , no effective therapy is available for its management .
The present systematic review and meta- analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF .