“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .
Xuezhikang, an Extract of Cholestin, Protects Endothelial Function Through Antiinflammatory and Lipid-Lowering Mechanisms in Patients With Coronary Heart Disease
Background —Endothelial dysfunction is associated with inflammation and postpr and ial hypertriglyceridemia . Xuezhikang , an extract of Cholestin , a dietary supplement , has lipid-modulating and antiinflammatory effects . We explored the effects of xuezhikang on endothelial function and high-sensitivity C-reactive protein ( hs-CRP ) in patients with coronary heart disease ( CHD ) . Methods and Results —We prospect ively r and omized 50 CHD patients to xuezhikang 1200 mg/d or placebo for 6 weeks .  Fasting hs-CRP concentrations , flow-mediated vasodilation ( FMD ) at 0 and 4 hours , and lipid parameters at 0 , 2 , 4 , and 6 hours were monitored after a high-fat meal ( 800 calories ; 50 g fat ) in all patients . All patients underwent a high-fat meal test at the beginning of the study and after 6 weeks of treatment . Postpr and ial FMD was significantly worse at 4 hours after a high-fat meal ( P<0.05 ) , and this was associated with the area under the triglyceride curve ( TG-AUC ) ( r=0.345 , P<0.01 ) . After 6 weeks of xuezhikang , fasting hs-CRP levels and TG-AUC ( P<0.001 for each ) decreased . Furthermore , prepr and ial and postpr and ial FMD significantly improved ( P<0.001 ) . There were no significant changes in serum lipids and FMD in the placebo arm . In multivariable regression analysis , changes in TG-AUC and fasting hs-CRP levels were predictive of improvement in prepr and ial FMD ( P<0.05 ) . Conclusions —Xuezhikang effectively improved prepr and ial and postpr and ial endothelial function through its potent antiinflammatory and lipid-lowering effects
“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .