Home-based exercise increased exercise capacity safely but did not improve quality of life in patients with chronic heart failure .
It could therefore be used to improve the management of people with chronic heart failure who do not have access to hospital-based exercise
QUESTIONS Does home-based exercise improve exercise capacity and quality of life in people with chronic heart failure ?
Is it safe ?
Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle
Background Chronic heart failure ( CHF ) is accompanied by an inflammatory activation which occurs both systemically and in the skeletal muscle . Exercise training has been shown to reduce the local expression of cytokines and inducible nitric oxide synthase ( iNOS ) in muscle biopsies of CHF patients . INOS-derived NO can inhibit oxidative phosphorylation and contribute to skeletal muscle dysfunction in CHF . Design To investigate the correlation between changes in local iNOS expression associated with regular exercise and changes in aerobic enzyme activities in the skeletal muscle of patients with CHF . Twenty male CHF patients [ ejection fraction 25 % ( SE 2 ) , age 54 ( SE 2 ) years ] were r and omized to a training ( n = 10 ) or a control group ( C , n = 10 ) . Methods At baseline and after 6 months skeletal muscle iNOS expression was measured by real-time polymerase chain reaction . INOS protein and protein nitrosylation were assessed by immunohistochemistry . Cytochrome c oxidase ( COX ) activity was quantified electrochemically using the Clark oxygen electrode . Results Exercise training led to a 27 % increase in cytochrome c oxidase activity [ from 21.8 ( SE 3.2 ) to 27.7 ( SE 3.5 ) nmol O2/mg per min , P=0.02 versus baseline ] . Changes in iNOS expression and iNOS protein content were inversely correlated with changes in COX-activity ( r= −0.60 , P=0.01 ; r= −0.71 , P<0.001 ) . Conclusions The inverse correlation between iNOS expression/iNOS protein content and COX-activity indicates that local anti-inflammatory effects may contribute to improved muscular oxidative metabolism
Home-based exercise increased exercise capacity safely but did not improve quality of life in patients with chronic heart failure .
It could therefore be used to improve the management of people with chronic heart failure who do not have access to hospital-based exercise
QUESTIONS Does home-based exercise improve exercise capacity and quality of life in people with chronic heart failure ?
Is it safe ?