AUTHORS ' CONCLUSIONS Feeding with a soy formula can not be recommended for prevention of allergy or food intolerance in infants at high risk of allergy or food intolerance .
BACKGROUND Allergies and food reactions in infants and children are common and may be associated with a variety of foods including adapted cow 's milk formula .
Soy based formulas have been used to treat infants with allergy or food intolerance .
However , it is unclear whether they can help prevent allergy and food intolerance in infants without clinical evidence of allergy or food intolerance .
OBJECTIVES To determine the effect of feeding adapted soy formula compared to human milk , cow 's milk formula or a hydrolysed protein formula on preventing allergy or food intolerance in infants without clinical evidence of allergy or food intolerance .
Patterns of food hypersensitivity during sixteen years of double-blind, placebo-controlled food challenges.
For 16 years the double-blind , placebo-controlled food challenge ( DBPCFC ) has been used at the National Jewish Center for Immunology and Respiratory Medicine to determine whether adverse reactions to foods do occur in children . The objective of these studies was to explore these reproducible adverse reactions and to characterize them . Although skin testing was performed on all subjects , a history of an adverse reaction to food and to subsequent DBPCFC were the only criteria for entry into this study . Of 480 children studied , 185 ( 39 % ) have had positive DBPCFC results . In these 480 children , 245 ( 24 % ) of 1014 DBPCFCs showed positive results . Egg , peanut , and cow milk accounted for 73 % of the positive DBPCFC reactions , but many foods produced reactions . Skin test results were positive in most children with a positive DBPCFC reaction , but the large number of patients with asymptomatic hypersensitivity limited the accuracy of a positive skin test result alone as a predictor of clinical symptoms during food ingestion . Evaluation of results in this large number of children for a prolonged period revealed reproducible patterns of symptoms , timing , and incriminated foods . Placebo reactions were rare . The procedure was safe . Twelve youngsters with a negative DBPCFC result subsequently had positive reactions to open challenges when large amounts of the challenge food were used . In each of these cases the reactions were limited to areas of direct contact with the food or could be explained by the larger amount of food ingested during the open challenge . Multiple food hypersensitivity has been a rare finding . The DBPCFC should be the " gold st and ard " for both research and clinical diagnostic evaluations until it is superseded by methods that have yet to be developed
AUTHORS ' CONCLUSIONS Feeding with a soy formula can not be recommended for prevention of allergy or food intolerance in infants at high risk of allergy or food intolerance .
BACKGROUND Allergies and food reactions in infants and children are common and may be associated with a variety of foods including adapted cow 's milk formula .
Soy based formulas have been used to treat infants with allergy or food intolerance .
However , it is unclear whether they can help prevent allergy and food intolerance in infants without clinical evidence of allergy or food intolerance .
OBJECTIVES To determine the effect of feeding adapted soy formula compared to human milk , cow 's milk formula or a hydrolysed protein formula on preventing allergy or food intolerance in infants without clinical evidence of allergy or food intolerance .