Results suggested that all therapies had little to no effect on pain and other patient-important outcomes .
Our findings are inconsistent with major clinical practice guidelines ; the available evidence suggests no beneficial effects of any therapies that research ers have evaluated in r and omized controlled trials
BACKGROUND AND PURPOSE Central poststroke pain is a chronic neuropathic disorder that follows a stroke .
Current research on its management is limited , and no review has evaluated all therapies for central poststroke pain .
A double-blind trial of naloxone in central post-stroke pain
& NA ; Intravenous naloxone has been cl aim ed to produce pain relief in opioid‐resistant central post‐stroke pain ( CPSP , ‘ thalamic syndrome ’ ) . In a double‐blind trial , carried out in 20 patients with established CPSP , naloxone ( up to 8 mg in 20 ml vehicle ) was tested against normal saline ; each patient was r and omly given naloxone or saline and the other substance 2 or 3 weeks later . VAS and verbal pain scores were obtained immediately before and after naloxone or saline injection , and subjective ratings followed for 2 weeks . Three patients obtained transient pain relief with naloxone , 4 with saline , and another 4 with both . Statistical tests failed to show any influence of giving naloxone first or second . In all cases except one , pain relief had disappeared by the evening of the day on which the test was performed ; one case , following naloxone , continued to experience pain relief until the following morning . We therefore conclude that intravenous naloxone is of no value in alleviating the pain of CPSP
Results suggested that all therapies had little to no effect on pain and other patient-important outcomes .
Our findings are inconsistent with major clinical practice guidelines ; the available evidence suggests no beneficial effects of any therapies that research ers have evaluated in r and omized controlled trials
BACKGROUND AND PURPOSE Central poststroke pain is a chronic neuropathic disorder that follows a stroke .
Current research on its management is limited , and no review has evaluated all therapies for central poststroke pain .