Such interventions would have the potential to reduce the prevalence of chronic pain in the population .
Although certain risk factors can identify individuals who are most likely to develop chronic pain , few interventions to prevent chronic pain have been identified .
To facilitate the identification of preventive interventions , an IMMPACT meeting was convened to discuss research design considerations for clinical trials investigating the prevention of chronic pain .
We present general design considerations for prevention trials in population s that are at relatively high risk for developing chronic pain .
Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain
Abstract Though it is clear that genomic variability plays an integral role in accounting for pain sensitivity , controversy exists over which genes are involved . While recent data suggest a “ protective ” ( i.e. , less pain ) haplotype in the GTP cyclohydrolase ( GCH1 ) gene , other research has failed to confirm this association . Possibly , the effects of single nucleotide polymorphisms ( SNPs ) vary depending on the pain task . The current investigation analyzed the association of five previously identified GCH1 SNPs with ratings of pain induced by topical high concentration ( 10 % ) capsaicin applied to the skin of 39 healthy human volunteers . Each of the GCH1 polymorphisms was associated with lower pain ratings . When combined , three of the five accounted for a surprisingly high 35 % of the inter‐individual variance in pain ratings . We conclude that SNPs of the GCH1 gene may profoundly affect the ratings of pain induced by capsaicin
Such interventions would have the potential to reduce the prevalence of chronic pain in the population .
Although certain risk factors can identify individuals who are most likely to develop chronic pain , few interventions to prevent chronic pain have been identified .
To facilitate the identification of preventive interventions , an IMMPACT meeting was convened to discuss research design considerations for clinical trials investigating the prevention of chronic pain .
We present general design considerations for prevention trials in population s that are at relatively high risk for developing chronic pain .