The present review demonstrates that vitamin D supplementation result ed in small but nonsignificant improvements in muscle strength compared to control in postmenopausal women .
No significant effect was observed in mobility after vitamin D administration
BACKGROUND The results obtained from previous trials regarding the effects of vitamin D supplementation on muscle strength and mobility  in postmenopausal women have been inconsistent .
This systematic review and meta- analysis of r and omised controlled trials ( RCTs ) aim ed to investigate the effect of vitamin D supplementation on muscle strength and mobility in postmenopausal women .
Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol
Objective This study aim ed to determine the effect of calcitriol on serum concentrations of fibroblast growth factor-23 ( FGF-23 ) , sclerostin , intact parathyroid hormone ( PTH ) , and h and grip strength in postmenopausal women with low bone mass . Methods A r and omized , double-blind controlled trial was carried out among 141 postmenopausal women with low bone mass . Participants were r and omized into two groups : 75 participants received calcitriol 0.5 µg/day and 66 participants received a placebo for 12 weeks . Results After 12-week calcitriol treatment , significant decreases in serum intact PTH ( P=0.035 ) and sclerostin ( P=0.039 ) , as well as significant increases in serum creatinine ( P=0.027 ) , uric acid ( P=0.032 ) , 24-hour urinary calcium ( P=0.0026 ) , and left h and grip strength ( P=0.03 ) , were observed , compared to placebo group . Level of serum sclerostin was weakly but significantly positively correlated with serum PTH ( r=0.277 ; P=0.01 ) and negatively correlated with 24-hour urinary calcium ( r=−0.221 ; P=0.04 ) and left h and grip strength ( r=−0.338 ; P=0.03 ) after calcitriol treatment . Multiple regression analysis demonstrated that decrease in serum sclerostin was associated with decrease in PTH serum level  after calcitriol treatment ( OR , 7.90 ; 95 % CI , 2.28–27.42 ; P=0.002 ) . However , no significant change in FGF-23 level was observed after calcitriol treatment . Conclusion Calcitriol treatment yields a considerable decrease in serum sclerostin and significant increase of h and grip strength , and the change in serum sclerostin is regulated by serum PTH and by muscle strength
The present review demonstrates that vitamin D supplementation result ed in small but nonsignificant improvements in muscle strength compared to control in postmenopausal women .
No significant effect was observed in mobility after vitamin D administration
BACKGROUND The results obtained from previous trials regarding the effects of vitamin D supplementation on muscle strength and mobility  in postmenopausal women have been inconsistent .
This systematic review and meta- analysis of r and omised controlled trials ( RCTs ) aim ed to investigate the effect of vitamin D supplementation on muscle strength and mobility in postmenopausal women .