The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
Comparison of two dentifrices with respect to efficacy for the control of plaque and gingivitis, and with respect to extrinsic tooth staining: a six-month clinical study on adults.
The objective of this six-month , double-blind clinical study , conducted in harmony with American Dental Association guidelines , was to provide a comparison between Colgate Total Toothpaste and Crest Gum Care Toothpaste with respect to their levels of efficacy for the control of supragingival dental plaque and gingivitis , and with respect to the levels of tooth staining associated with their use . Adult male and female subjects from the Edinburgh , Scotl and area were entered into the study and stratified into two treatment groups which were balanced for age , sex , baseline Quigley-Hein Plaque Index scores and baseline Löe-Silness Gingival Index scores . Subjects received an oral prophylaxis , and were instructed to brush their teeth twice daily ( morning and evening ) for one minute with their assigned dentifrice , using a soft-bristled toothbrush . Examinations for plaque , gingivitis and extrinsic tooth staining were conducted after three months ' and again after six months ' use of the study dentifrices . One-hundred and nine ( 109 ) subjects complied with the protocol and completed the entire six-month clinical study . At both the three- and six-month study examinations , the Colgate Total Toothpaste group exhibited statistically significantly less plaque , gingivitis and extrinsic tooth staining compared to the Crest Gum Care Toothpaste group . At the six-month examination , the magnitude of these differences exceeded 18 % for all six parameters measured ( 18.7 % for Plaque Index , 60.5 % for Plaque Severity Index , 22.2 % for Gingival Index , 85.1 % for Gingivitis Severity Index , 45.3 % for stain intensity , and 46.3 % for stain area ) . Thus , the results of this six-month clinical study support the conclusion that Colgate Total Toothpaste provides a statistically significant , substantive advantage in efficacy for the control of plaque and gingivitis over Crest Gum Care Toothpaste , while , at the same time , providing better control against the development of extrinsic tooth staining
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .