Differences were potentially attributable to differences in infant risk , prebiotic formulation or measurement of eczema .
There is insufficient evidence to determine the role of prebiotic supplementation of infant formula for prevention of allergic disease and food hypersensitivity .
Further trials are needed to determine whether this finding persists over a longer period of time , applies to other manifestations of allergic disease , is associated with reductions in allergen sensitisation , and is reproducible
BACKGROUND The composition of the intestinal microflora may be different in individuals with atopic eczema from those without this condition , and such differences may precede the development of eczema .
Prebiotics are nondigestible food components that benefit the host by selectively stimulating the growth or activity of non-pathogenic bacteria in the colon .
Prebiotics ( commonly oligosaccharides ) added to infant feeds have the potential to prevent sensitisation of infants to dietary allergens .
OBJECTIVES To determine the effect of prebiotics given to infants for the prevention of allergic disease or food hypersensitivity .
Lactobacillus GG effect in increasing IFN-gamma production in infants with cow's milk allergy.
BACKGROUND Probiotic bacteria are potentially beneficial to maturation of the infant 's immune system . OBJECTIVE To examine the role of probiotic bacteria in treatment of cow 's milk allergy ( CMA ) and IgE-associated dermatitis , we investigated the immunologic effects of Lactobacillus rhamnosus GG ( LGG ) and a mixture of 4 bacterial species ( MIX ) . METHODS In a r and omized , double-blind study design , concomitantly with elimination diet and skin treatment , LGG , MIX , or placebo was given for 4 weeks to infants with suspected CMA . After anti-CD3 ( OKT3 ) and anti-CD28 stimulation of P BMC s , IFN-gamma , IL-4 , IL-5 , and IL-12 levels were measured in culture supernatants by ELISA . Intracellular IFN-gamma , IL-4 , and IL-5 production on CD4 lymphocytes was analyzed with fluorescence-activated cell sorting . RESULTS Secretion of IFN-gamma by P BMC s before the treatment was significantly lower in infants with CMA ( P=.016 ) and in infants with IgE-associated CMA ( P=.003 ) than in non-CMA infants . Among the infants who received LGG , the level of secreted IFN-gamma increased in those with CMA ( P=.006 ) and in those with IgE-associated dermatitis ( P=.017 ) when compared with the placebo group . Secretion of IL-4 increased significantly in infants with CMA in the MIX ( P=.034 ) but not in the LGG group . CONCLUSION Deficiency in IFN-gamma response appears to be related to CMA . LGG raises IFN-gamma production of P BMC in infants with CMA and in infants with IgE-associated dermatitis and may thus provide beneficial TH1 immunomodulatory signals . MIX , although containing LGG , appears to modulate the immune responses differently
Differences were potentially attributable to differences in infant risk , prebiotic formulation or measurement of eczema .
There is insufficient evidence to determine the role of prebiotic supplementation of infant formula for prevention of allergic disease and food hypersensitivity .
Further trials are needed to determine whether this finding persists over a longer period of time , applies to other manifestations of allergic disease , is associated with reductions in allergen sensitisation , and is reproducible
BACKGROUND The composition of the intestinal microflora may be different in individuals with atopic eczema from those without this condition , and such differences may precede the development of eczema .
Prebiotics are nondigestible food components that benefit the host by selectively stimulating the growth or activity of non-pathogenic bacteria in the colon .
Prebiotics ( commonly oligosaccharides ) added to infant feeds have the potential to prevent sensitisation of infants to dietary allergens .
OBJECTIVES To determine the effect of prebiotics given to infants for the prevention of allergic disease or food hypersensitivity .