Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Effects of an in-patient treatment program based on regular exercise and a balanced diet on high molecular weight adiponectin, resistin levels, and insulin resistance in adolescents with severe obesity.
Adiponectin , the most abundant hormone produced by adipose tissue , circulates in 3 isoforms , including high molecular weight ( HMW ) adiponectin . The latter has been suggested to be a better predictor of metabolic disturbances and insulin resistance associated with obesity . This study investigated changes in total and HMW adiponectin , resistin , and homeostasis model assessment ( HOMA ) during a 9-month in-patient treatment program based on physical exercise and a balanced diet in 32 severely obese adolescents .  Total and HMW adiponectin , resistin , and HOMA were measured at baseline ( month 0 ) and during the program ( months 3 , 6 , 9 ) . In addition , a control group of 15 teenagers served as a reference for the baseline assessment s. At baseline , HMW adiponectin was more markedly decreased in obese adolescents than total adiponectin , and both were lower than in controls . Conversely , resistin and HOMA were higher in obese adolescents . During the program , there was a significant change in body composition and improved insulin sensitivity among obese teenagers . In addition , HMW adiponectin and the ratio of HMW-to-total adiponectin increased throughout the study , whereas total adiponectin only increased up until the sixth month . On the contrary , resistin did not show any significant change . In obese adolescents , a long-term combination of aerobic exercise and a balanced diet , inducing change in body composition and improved insulin sensitivity , markedly increased HMW adiponectin compared with total adiponectin , without any change in resistin concentrations . Our results thus suggest that the determination of HMW adiponectin could be more useful than measurement of total adiponectin in clinical setting
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .