However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .
Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans
Excess ectopic fat storage is linked to type 2 diabetes . The importance of dietary fat composition for ectopic fat storage in humans is unknown . We investigated liver fat accumulation and body composition during overfeeding saturated fatty acids ( SFAs ) or polyunsaturated fatty acids ( PUFAs ) . LIPOGAIN was a double-blind , parallel-group , r and omized trial . Thirty-nine young and normal-weight individuals were overfed muffins high in SFAs ( palm oil ) or n-6 PUFAs ( sunflower oil ) for 7 weeks .  Liver fat , visceral adipose tissue ( VAT ) , abdominal subcutaneous adipose tissue ( SAT ) , total adipose tissue , pancreatic fat , and lean tissue were assessed by magnetic resonance imaging . Transcriptomics were performed in SAT . Both groups gained similar weight . SFAs , however , markedly increased liver fat compared with PUFAs and caused a twofold larger increase in VAT than PUFAs . Conversely , PUFAs caused a nearly threefold larger increase in lean tissue than SFAs . Increase in liver fat directly correlated with changes in plasma SFAs and inversely with PUFAs . Genes involved in regulating energy dissipation , insulin resistance , body composition , and fat-cell differentiation in SAT were differentially regulated between diets , and associated with increased PUFAs in SAT . In conclusion , overeating SFAs promotes hepatic and visceral fat storage , whereas excess energy from PUFAs may instead promote lean tissue in healthy humans
However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .