This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
Favorable effects of vitamin D supplementation on pregnancy outcomes in gestational diabetes: a double blind randomized controlled clinical trial.
Gestational diabetes mellitus ( GDM ) has been recognized as a significant risk factor for unfavorable pregnancy outcomes . Prevalence of vitamin D deficiency is highly prevalent among women with GDM . This study was design ed to assess the effect of vitamin D supplementation on pregnancy outcomes of pregnant women with GDM who were not on oral hypoglycemic agents . This r and omized controlled clinical trial was performed among 45 pregnant women diagnosed with GDM at 24 - 28 weeks ' gestation . Subjects were r and omly assigned to consume either vitamin D supplements ( cholecalciferol ) or placebo . Individuals in the vitamin D group ( n=22 ) received 50 000 IU vitamin D3 pearl 2 times during the study : at study baseline and day 21 of intervention and those in placebo group ( n=23 ) received 2 placebos at the mentioned times . Fasting blood sample s were taken at baseline to measure fasting plasma glucose . Participants underwent a 3-h oral glucose tolerance tests ( OGTT ) and the blood sample s were collected at time 60 , 120 , and 180 min to measure plasma glucose levels . Newborn 's weight , height , head circumference , Apgar score , and hyperbilirubinemia were determined . Taking vitamin D supplements , compared with placebo , result ed in improved pregnancy outcomes ; such that those in the vitamin D group had no case of polyhydramnios , while 17.4 % of subjects in placebo group had this condition ( p=0.04 ) . In addition , newborn 's hyperbilirubinemia was significantly lower in vitamin D group than that in placebo group ( 27.3 % vs. 60.9 % , p=0.02 ) . In conclusion , vitamin D supplementation for 6 weeks among pregnant women with GDM result ed in decreased maternal polyhydramnios and infant hyperbilirubinemia compared with placebo . Clinical trial registration number www.i rct .ir : I RCT 201305115623N7
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .