The results showed that , compared with placebo , pethidine , fentanyl , dexmedetomidine , and sufentanil significantly reduced the incidence of perioperative shivering .
In addition , compared with sufentanil , fentanyl showed no impact on haemodynamic stability and the incidence of pruritus .
CONCLUSION Pethidine , fentanyl , dexmedetomidine , and sufentanil appear to be effective for preventing perioperative shivering in puerperae undergoing cesarean sections .
Considering the risk-benefit profiles of the included neuraxial adjuvants , fentanyl is probably the optimal choice
BACKGROUND Perioperative shivering is clinical ly common during cesarean sections under neuraxial anesthesia , and several neuraxial adjuvants are reported to have preventive effects on it .
However , the results of current studies are controversial and the effects of these neuraxial adjuvants remain unclear .
AIM To evaluate the effects of neuraxial adjuvants on perioperative shivering during cesarean sections , thus providing an optimal choice for clinical application .
Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial
Introduction Shivering is among the unpleasant and potentially harmful side effects of spinal anesthesia . The aim of this r and omized double-blind clinical trial was to compare the antishivering effect of two different doses of intrathecal pethidine on the incidence and intensity of shivering and other side effects in patients who underwent cesarean section . Methods In this study , 150 parturient females scheduled for nonemergent cesarean section were r and omly allocated to three groups . Spinal anesthesia was performed with 0.5 % hyperbaric bupivacaine ( 12.5 mg ) , plus 0.5 mL of 0.9 % saline in the st and ard group ( S group ) , and the same dose of bupivacaine with 5 mg ( P5 group ) or 10 mg of pethidine ( P10 group ) . Demographic and surgical data , incidence and intensity of shivering ( primary outcome ) , hemodynamic indices , forehead and core temperatures , maximum sensory level , Apgar scores , and adverse events were evaluated by a blinded observer . Results There were no significant differences between the three study groups regarding the demographic and surgical data , hemodynamic indices , core temperatures , and maximum sensory level ( P>0.05 ) . The incidence and intensity of shivering were significantly less in the P5 and P10 groups ( P<0.001 ) when compared with the S group . There were no significant differences between groups for secondary outcomes , except pruritus , which was more common in the P5 and P10 groups when compared with the S group ( P=0.01 ) . Conclusion Low dose of intrathecal pethidine is safe , and can decrease the incidence and intensity of shivering during cesarean section , without having major side effects
The results showed that , compared with placebo , pethidine , fentanyl , dexmedetomidine , and sufentanil significantly reduced the incidence of perioperative shivering .
In addition , compared with sufentanil , fentanyl showed no impact on haemodynamic stability and the incidence of pruritus .
CONCLUSION Pethidine , fentanyl , dexmedetomidine , and sufentanil appear to be effective for preventing perioperative shivering in puerperae undergoing cesarean sections .
Considering the risk-benefit profiles of the included neuraxial adjuvants , fentanyl is probably the optimal choice
BACKGROUND Perioperative shivering is clinical ly common during cesarean sections under neuraxial anesthesia , and several neuraxial adjuvants are reported to have preventive effects on it .
However , the results of current studies are controversial and the effects of these neuraxial adjuvants remain unclear .
AIM To evaluate the effects of neuraxial adjuvants on perioperative shivering during cesarean sections , thus providing an optimal choice for clinical application .