There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain .
Non-steroidal anti-inflammatory drugs ( NSAIDs ) are medications that are frequently used by athletes .
There may also be some abuse of these substances , although it is unclear whether NSAIDs in fact enhance performance .
We performed a systematic review and meta- analysis to evaluate the effect of NSAIDs on sport performance indices .
Effects of low-dose ibuprofen supplementation and resistance training on bone and muscle in postmenopausal women: A randomized controlled trial
Purpose To compare the effects of nine months of exercise training and ibuprofen supplementation ( given immeditately after exercise sessions ) on bone and muscle in postmenopausal women . Methods In a double-blind r and omized trial , participants ( females : n = 90 , mean age 64.8 , SD 4.3 years ) were assigned ( computer generated , double blind ) to receive supervised resistance training or stretching 3 days/week , and ibuprofen ( 400 mg , post-exercise ) or placebo ( i.e. 4 groups ) for 9 months . In this proof-of-concept study the sample size was halved from required 200 identified via 90 % power calculation . Baseline and post-intervention testing included : Dual energy x-ray absorptiometry ( DXA ) for lumbar spine , femoral neck , and total body areal bone mineral density ( aBMD ) ; geometry of proximal femur ; total body lean tissue and fat mass ; predicted 1-repetition maximum muscle strength testing ( 1RM ; biceps curl , hack squat ) . Results Exercise training or ibuprofen supplementation had no effects on aBMD of the lumbar spine , femoral neck , and total body . There was a significant exercise × supplement × time interaction for aBMD of Ward 's region of the femoral neck ( p = 0.015 ) with post hoc comparison showing a 6 % decrease for stretching with placebo vs. a 3 % increase for stretching with ibuprofen ( p = 0.017 ) . Resistance training increased biceps curl and hack squat strength vs. stretching ( 22 % vs. 4 % and 114 % vs. 12 % , respectively ) ( p < 0.01 ) and decreased percent body fat compared to stretching ( 2 % vs. 0 % ) ( p < 0.05 ) . Conclusions Ibuprofen supplementation provided some benefits to bone when taken independent of exercise training in postmenopausal women . This study provides evidence towards a novel , easily accessible stimulus for enhancing bone health [ i.e. ibuprofen ]
There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain .
Non-steroidal anti-inflammatory drugs ( NSAIDs ) are medications that are frequently used by athletes .
There may also be some abuse of these substances , although it is unclear whether NSAIDs in fact enhance performance .
We performed a systematic review and meta- analysis to evaluate the effect of NSAIDs on sport performance indices .