RESULTS Increased TFA intake did not result in significant changes in glucose or insulin concentrations .
Our analysis also showed the absence of publication bias and any dose-response relations between the ES and TFA intake .
Increased TFA intake does not result in changes in glucose , insulin , or triglyceride concentrations but leads to an increase in total and LDL-cholesterol and a decrease in HDL-cholesterol concentrations .
There is no evidence to support a potential benefit of the reduction of dietary TFA intake on glucose homeostasis
BACKGROUND Although evidence from cohort studies has suggested that trans fatty acid ( TFA ) consumption may be associated with insulin resistance and diabetes , r and omized placebo-controlled trials ( RCTs ) have yielded conflicting results .
OBJECTIVE In a meta- analysis , we combined all available RCTs that examined the role of  TFA intake  on  glucose homeostasis .
Influence of hydrogenated fat and butter on CVD risk factors: remnant-like particles, glucose and insulin, blood pressure and C-reactive protein.
Dietary trans fatty acids/partially-hydrogenated fat has been associated with increased risk of developing cardiovascular disease ( CVD ) , possibly greater than predicted from changes in lipoprotein levels . To explore this issue further potential risk factors were assessed in subjects provided with each of six diets in r and omized order containing as the major source of fat : soybean oil , semi-liquid margarine , soft margarine , shortening , traditional stick margarine or butter .  Plasma fatty acid profiles reflected diet , with triglyceride and phospholipid subfractions affected to a greater extent than cholesteryl ester . Non-fasting LDL-cholesterol levels were 144+/-27 , 141+/-27 , 146+/-26 , 148+/-30 , 151+/-29 and 165+/-31 mg/dl ( P<0.001 ) and total cholesterol/HDL-cholesterol ratios were 5.50+/-1.25 , 5.54+/-1.50 , 5.69+/-1.29 , 5.82+/-1.40 , 6.11+/-1.30 and 5.94+/-1.43 ( P=0.011 ) , respectively , whereas other lipoprotein levels were not significantly different . Remnant-like particles levels were unaffected by dietary fat , either in the fasting or non-fasting state . Differences in fasting insulin and glucose levels were small and would not be predicted to have a large impact on glucose homeostasis . There was no significant effect of dietary fat type on C-reactive protein levels or blood pressure . These data suggest that , as previously demonstrated , the major CVD risk factor adversely affected by dietary trans fatty acids/partially-hydrogenated fat is LDL-cholesterol levels and total cholesterol/HDL-cholesterol ratios
RESULTS Increased TFA intake did not result in significant changes in glucose or insulin concentrations .
Our analysis also showed the absence of publication bias and any dose-response relations between the ES and TFA intake .
Increased TFA intake does not result in changes in glucose , insulin , or triglyceride concentrations but leads to an increase in total and LDL-cholesterol and a decrease in HDL-cholesterol concentrations .
There is no evidence to support a potential benefit of the reduction of dietary TFA intake on glucose homeostasis
BACKGROUND Although evidence from cohort studies has suggested that trans fatty acid ( TFA ) consumption may be associated with insulin resistance and diabetes , r and omized placebo-controlled trials ( RCTs ) have yielded conflicting results .
OBJECTIVE In a meta- analysis , we combined all available RCTs that examined the role of  TFA intake  on  glucose homeostasis .