Best- evidence synthesis demonstrated a conflicting level of evidence for associations between the use of-amphetamine-type substances and the risk of sustaining an injury , and a moderate level of evidence between amphetamine use and the risk of death due to road trauma .
This is the first review to synthesis e evidence regarding the association between amphetamine-type substance use and the risk of injury or death due to a road traffic accident .
More conclusive evidence of death due to road trauma among amphetamine users may reflect significant and global deficits in functioning associated with effective vehicular control under the influence of this substance .
Amphetamine-type substances are frequently detected among drivers injured or killed due to road-trauma .
However , the role of this substance in crash causation remains equivocal .
We performed a systematic review to evaluate existing evidence regarding the association between amphetamine use and the risk of injury or death due to road traffic accidents .
The effects of dexamphetamine on simulated driving performance
Rationale The number of road fatalities related to the presence of amphetamines in drivers has been relatively constant over the past 10 years . However , there remains uncertainty as to the extent that these drugs induce driving impairment , and whether any such impairments translate to an increase in road fatalities . Objectives To examine the acute effects of 0.42 mg/kg dexamphetamine on simulated driving performance , and to establish which , if any , simulated driving abilities become impaired following dexamphetamine administration . Methods A repeated- measures , counter-balanced , double-blind , placebo-controlled design was employed . Twenty healthy volunteers completed two treatment conditions—0.42 mg/kg dexamphetamine and placebo . Performance was assessed using a driving simulator task .  Blood and saliva sample s were obtained prior to the driving tasks and immediately after task completion ( 120 min and 170 min post-drug administration , respectively ) . Results Mean dexamphetamine blood concentrations were 83 ng/ml and 98 ng/ml at 120 min and 170 min , respectively . Results indicated a decrease in overall simulated driving ability following dexamphetamine administration during the day-time but not the night-time scenario tasks . Contributing to this performance reduction , “ incorrect signalling ” , “ failing to stop at a red traffic light ” and “ slow reaction times ” were the behaviours most strongly affected by dexamphetamine . Conclusions The decrease in simulated driving ability observed during the day-time driving tasks are consistent with the perceptual narrowing or tunnel vision that is associated with dexamphetamine consumption
Best- evidence synthesis demonstrated a conflicting level of evidence for associations between the use of-amphetamine-type substances and the risk of sustaining an injury , and a moderate level of evidence between amphetamine use and the risk of death due to road trauma .
This is the first review to synthesis e evidence regarding the association between amphetamine-type substance use and the risk of injury or death due to a road traffic accident .
More conclusive evidence of death due to road trauma among amphetamine users may reflect significant and global deficits in functioning associated with effective vehicular control under the influence of this substance .
Amphetamine-type substances are frequently detected among drivers injured or killed due to road-trauma .
However , the role of this substance in crash causation remains equivocal .
We performed a systematic review to evaluate existing evidence regarding the association between amphetamine use and the risk of injury or death due to road traffic accidents .