LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Efficacy and safety of morning versus evening dose of controlled-release simvastatin tablets in patients with hyperlipidemia: a randomized, double-blind, multicenter phase III trial.
BACKGROUND Flexibility in the recommended dosing time for a statin may improve patient compliance . OBJECTIVE This study was design ed to compare the efficacy and tolerability of morning and evening doses of controlled-release simvastatin in Korean adults with dyslipidemia . It was carried out as a requirement to obtain authorization from the Korean regulatory agency to market the product . METHODS In this prospect i ve , r and omized , double-blind , multicenter , placebo-controlled Phase III study , we r and omly assigned 132 patients with hypercholesterolemia to a morning-dose group or an evening-dose group . Patients in the morning-dose group received 20 mg controlled-release simvastatin in the morning and a placebo in the evening , and those in the evening-dose group received a placebo in the morning and 20 mg controlled-release simvastatin in the evening . RESULTS After 8 weeks of the treatment , the difference in the mean change of LDL-C between the morning-dose and evening-dose groups was -2.78 % ( 95 % confidence interval , -7.65 to 2.10 ) . The changes in total cholesterol , triglycerides , HDL-C , apolipoprotein A1 , apolipoprotein B , and lipoprotein ( a ) after treatment did not differ between groups . Also , the achievement rates of the target LDL-C goal suggested by the dyslipidemia treatment guideline of the Korean Society of Lipidology and Atherosclerosis were not different . No serious adverse event was observed in either group . Mild and moderate adverse events were observed similarly in both groups . CONCLUSIONS Although controlled-release simvastatin significantly reduces LDL-C levels with good tolerability in Korean adults with dyslipidemia , the time of administration does not affect its efficacy
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .