The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Combined enalapril and felodipine extended release (ER) for systemic hypertension. Enalapril-Felodipine ER Factorial Study Group.
This multicenter , placebo-controlled , double-blind trial of factorial design evaluated the safety and efficacy of combination treatment with the angiotensin-converting enzyme inhibitor , enalapril , and the vascular selective calcium antagonist felodipine extended release ( ER ) in patients with essential hypertension . After a 4-week , single-blind placebo baseline period , 707 patients with sitting diastolic blood pressures ( BPs ) in the range of 95 to 115 mm Hg received placebo , enalapril ( 5 or 20 mg ) , felodipine ER ( 2.5 , 5 , or 10 mg ) , or their combinations for an 8-week double-blind treatment period . All doses of enalapril and felodipine ER had a statistically significant ( p < 0.05 ) additive effect in reducing both systolic and diastolic BP . The trough to peak ratios for the combinations ranged from 0.63 ( enalapril 5 mg-felodipine ER 2.5 mg ) to 0.79 ( enalapril 20 mg-felodipine ER 10 mg ) and were consistent with effective BP control with 1 dose/day . Patients aged > or = 65 years demonstrated a greater reduction in diastolic BP . Combinations of enalapril-felodipine ER were associated with less drug-induced peripheral edema ( 4.1 % ) compared to felodipine ER monotherapy ( 10.8 % ) . There were no serious drug-related adverse effects observed during the study . In this trial , the combination of enalapril and felodipine ER effectively lowered BP and was generally well tolerated with an excellent safety profile when used in the treatment of hypertension
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .