Our data suggested that N.S supplementation had significant impacts on liver and kidney parameters leading to a decrease in ALP and BUN levels .
The aim of this systematic review and dose-response meta- analysis was to determine the effect of Nigella Sativa ( N.S ) supplementation on  liver and kidney parameters .
Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic inflammation in obese women: A randomized double-blind, placebo-controlled clinical trial.
BACKGROUND Inflammation is one of the primary mechanisms in the development of metabolic complications . Although anti-inflammatory characteristics of Nigella sativa ( NS ) have been indicated in animal models , clinical trials related to the effects of NS on inflammatory parameters are relatively scarce . OBJECTIVE The aim of the present study was to determine the effects of NS oil combined with a calorie-restricted diet on systemic inflammatory biomarkers in obese women . METHODS In this double-blind placebo-controlled r and omized clinical trial , 90 volunteer obese ( body mass index = 30 - 34.9 kg/m(2 ) ) women aged 25 - 50 years were recruited . Participants were r and omly divided into two groups , an intervention group ( n = 45 ) and a placebo group ( n = 45 ) . Each group received either : ( 1 ) a low-calorie diet with 3 g/day of NS oil or ( 2 ) a low-calorie diet with 3 g/day placebo for 8 weeks . RESULTS A total of 84 females ( intervention group = 43 ; placebo group = 41 ) completed the trial . Subjects in the intervention group did not report any side effects with the NS oil supplementation . NS oil decreased serum levels of tumor necrosis factor-alpha ( -40.8 % vs -16.1 % , P = .04 ) and high-sensitivity C-reactive protein ( -54.5 % vs -21.4 % , P = .01 ) compared to the placebo group . However , there were no significant changes in interleukin-6 levels ( -8.6 vs -2.4 % , P = .6 ) in the NS group compared to the placebo group . CONCLUSIONS NS oil supplementation combined with a calorie-restricted diet may modulate systemic inflammatory biomarkers in obese women . However , more studies are needed to clarify the efficacy of NS oil as an adjunct therapy to improve inflammatory parameters in obese subjects
Our data suggested that N.S supplementation had significant impacts on liver and kidney parameters leading to a decrease in ALP and BUN levels .
The aim of this systematic review and dose-response meta- analysis was to determine the effect of Nigella Sativa ( N.S ) supplementation on  liver and kidney parameters .