Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .
Pentraxin 3 and Platelet Activation in Obese Patients After Gastric Banding.
BACKGROUND Circulating pentraxin 3 ( PTX3 ) , the main regulator of the inflammatory response , rapidly increases following cardiovascular events , and low PTX3 is associated with high body mass index . METHODS AND RESULTS We conducted a 12-month longitudinal study , to test the hypothesis that laparoscopic adjustable gastric b and ing (LAGB)-induced weight loss was associated with changes in platelet activation markers and PTX3 . Twelve obese patients , scheduled to undergo LAGB , were enrolled at the University Obesity Center . Urinary 11-dehydro-thromboxane (Tx)B2excretion rate was measured on radioimmunoassay , and PTX3 and CD40L were determined on immunoassay .  Plasma PTX3  increased by 178.8 and 214.9 % ( P<0.0001 ) , respectively , 6 and 12 months after LAGB . High-sensitivity CRP decreased by 24 and 29.7 % ( P<0.0001 ) , whereas CD40L decreased by 64.3 and 58.6 % ( P=0.002 ) , respectively . Urinary 11-dehydro-TxB2decreased from 1,443 to 715 and 564 pg/mg creatinine , respectively 6 months and 12 months after LAGB ( P<0.0001 ) . PTX3 was inversely related to platelet activation markers , 11-dehydro-TxB2 and CD40L . Moreover , multiple regression analysis on pooled data showed that plasma PTX3 was an independent predictor of urinary 11-dehydro-TxB2 . CONCLUSIONS There is an association between inflammation , platelet activation and metabolic dysfunction in obesity , and PTX3 is a key player within these circuits
Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .