Pelvic floor exercises are more effective in subjective and objective outcomes with biofeedback or verbal feedback .
Weight loss with diet and exercise , caffeine reduction , 25 - 50 % reduction in fluid intake , and pelvic floor muscle exercises with verbal instruction and or biofeedback were all efficacious .
Botulinum toxin A improves urge incontinence episodes , urgency , frequency , quality of life , nocturia , and urodynamic testing parameters .
Acupuncture  improves quality of life and urodynamic testing parameters .
Extracorporeal magnetic stimulation improves urodynamic parameters .
Mirabegron improves daily incontinence episodes , nocturia , number of daily voids , and urine volume per void , whereas solabegron improves daily incontinence episodes .
Short-term posterior tibial nerve stimulation is more efficacious than pelvic floor muscle training exercises and behavioral therapy for improving : urgency , urinary incontinence episodes , daily voids , volume per void , and overall quality of life .
Sacral neuromodulation is more efficacious than antimuscarinic treatment for subjective improvement of overactive bladder and quality of life .
Transvaginal electrical stimulation demonstrates subjective improvement in overactive bladder symptoms and urodynamic parameters .
Multiple therapies , including physical therapy , behavioral therapy , botulinum toxin A , acupuncture , magnetic stimulation , mirabegron , posterior tibial nerve stimulation , sacral neuromodulation , and transvaginal electrical stimulation , are efficacious in the treatment of overactive bladder
The purpose of the study was to determine the efficacy and safety of nonantimuscarinic treatments for overactive bladder .
Sacral Root Neuromodulation in the Treatment of Refractory Urinary Urge Incontinence: A Prospective Randomized Clinical Trial
Objectives : To compare the effectiveness of sacral root neuromodulation with that of conservative management in ameliorating symptoms of  refractory urinary urge incontinence  and enhancing quality of life , to assess the objective response to neuromodulation as revealed by urodynamic testing , and to delineate the long – term outcomes of neuromodulation . Methods : Forty – four patients with refractory urge incontinence were r and omized to undergo neuromodulation with an implantable impulse generator ( n = 21 ) or to continue their prior conservative management ( n = 23 ) . At 6 months the control group was eligible for crossover to implant . Patient evaluation included voiding diaries , quality of life question naires , urodynamic testing , and documentation of adverse events . Long – term follow – up evaluations were conducted at 6–month intervals up to 36 months . Results : At 6 months mean leakage episodes , leakage severity and pad usage in the implant group were significantly lower by 88 % ( p < 0.0005 ) , 24 % ( p = 0.047 ) and 90 % ( p < 0.0005 ) , respectively , than the corresponding control group mean values . Improvements in leakage episodes and pad usage of ≥90 % were attained by 75 and 85 % of the implant group , respectively , but none of the control group . One third of implant patients , but none of the control patients , achieved ≥50 % improvement in leakage severity . Over half of the implant patients ( 56 % ) were completely dry compared with 1 control patient ( 4 % ) . Implant patients , but not control patients , exhibited significant improvement with respect to two quality of life measures . Neuromodulation result ed in increases of 220 % ( p < 0.0005 ) and 39 % ( p = 0.013 ) , respectively , in urodynamically assessed bladder volume at first contraction and maximum fill . At 36 months the actuarial rate of treatment failure was 32.4 % ( 95 % CI , 17.0–56.0 % ) . Adverse events most frequently involved pain at the implant site , and the incidence of serious complications was low . Conclusions : Neuromodulation is markedly more effective than conservative management in alleviating symptoms of refractory urge incontinence . Quality of life and urodynamic function are also improved by neuromodulation . The effects of neuromodulation are long – lasting , and associated morbidity is low
Pelvic floor exercises are more effective in subjective and objective outcomes with biofeedback or verbal feedback .
Weight loss with diet and exercise , caffeine reduction , 25 - 50 % reduction in fluid intake , and pelvic floor muscle exercises with verbal instruction and or biofeedback were all efficacious .
Botulinum toxin A improves urge incontinence episodes , urgency , frequency , quality of life , nocturia , and urodynamic testing parameters .
Acupuncture  improves quality of life and urodynamic testing parameters .
Extracorporeal magnetic stimulation improves urodynamic parameters .
Mirabegron improves daily incontinence episodes , nocturia , number of daily voids , and urine volume per void , whereas solabegron improves daily incontinence episodes .
Short-term posterior tibial nerve stimulation is more efficacious than pelvic floor muscle training exercises and behavioral therapy for improving : urgency , urinary incontinence episodes , daily voids , volume per void , and overall quality of life .
Sacral neuromodulation is more efficacious than antimuscarinic treatment for subjective improvement of overactive bladder and quality of life .
Transvaginal electrical stimulation demonstrates subjective improvement in overactive bladder symptoms and urodynamic parameters .
Multiple therapies , including physical therapy , behavioral therapy , botulinum toxin A , acupuncture , magnetic stimulation , mirabegron , posterior tibial nerve stimulation , sacral neuromodulation , and transvaginal electrical stimulation , are efficacious in the treatment of overactive bladder
The purpose of the study was to determine the efficacy and safety of nonantimuscarinic treatments for overactive bladder .