Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .
Phase 2 Cross-Over Multicenter Trial on the Efficacy and Safety of Topical Cyanoacrylates Compared with Topical Silicone Gel in the Prevention of Pathologic Scars
Background Many clinical studies on scar therapy are reported in the literature , but only silicone gel sheeting and corticosteroid injections are supported by accurate prospect i ve controlled studies . This prospect i ve multicenter cross-over phase 2 study tested the effectiveness of a topical cyanoacrylate compared with silicone gel in improving postsurgical scars Methods Patients presenting with symmetric breast scars after augmentation or reduction mammaplasty were enrolled in the study . From the same day as stitch removal , the cyanoacrylate was applied on one side every 3 to 5 days and the silicone gel on the other side twice a day for 3 months . Assessment s of patients and external observers using a visual analog scale were recorded at scheduled visits during 1 year , and scars were photographed . Objective evaluations included measurements of scar width , length , and elevation . The statistical significance of objective parameter modifications was analyzed using the Wilcoxon test Results Positive effects of both tested products were observed during the scar maturation process , and final scars of good quality were achieved without any major adverse effect . The topical cyanoacrylate proved to be more efficacious in preventing scar widening , and this result was statistically significant Conclusions The tested topical cyanoacrylate had a positive effect on the scar maturation process at least comparable with that of topical silicone gel
Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .