For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .
The efficacy and safety of oral sildenafil in Thai men with erectile dysfunction: a randomized, double-blind, placebo controlled, flexible-dose study.
OBJECTIVE To evaluate the efficacy and safety of sildenafil citrate ( Viagra ) in a r and omized , double-blind , placebo-controlled , flexible-dose study in Thai men with erectile dysfunction of broad-spectrum etiology and more than 6 months ' duration . MATERIAL AND METHOD 125 patients aged 26 to 77 years were r and omized at 4 centers in Thail and to receive either sildenafil citrate ( 50 mg initially , increased if necessary up to 100 mg or decreased to 25 mg depending on efficacy and /or tolerability ) ( n = 63 ) or a matching placebo ( n = 62 ) taken on an ' as needed ' basis approximately 1 hour prior to anticipated sexual activity for a period of 12 weeks . Efficacy was assessed by the patients ' responses to the 15- question International Index of Erectile Function ( IIEF ) , to questions on the event log of sexual activity , and to the global efficacy assessment question concerning improvement in erections . RESULTS At the conclusion of the study , both the primary efficacy variables relating to the achievement and maintenance of erections sufficient for sexual intercourse and the secondary efficacy variables , which included the 5 separate domains of sexual functioning of the IIEF , the percentage of successful attempts at sexual intercourse , and the global efficacy assessment question concerning improvement in erections , were all significantly improved statistically by sildenafil in comparison with placebo except in the sexual desire domain which showed no difference . The percentage of successful attempts at sexual intercourse in the sildenafil group was 66.16 per cent while in the placebo group it was 33.05 per cent . The percentage of global efficacy assessment was improved in the sildenafil group by 82.5 per cent compared to 36.1 per cent in the placebo group . Adverse events considered treatment-related occurred in 19 patients ( 30.2 % ) receiving sildenafil and 7 ( 11.3 % ) receiving placebo . The most common adverse events with sildenafil were vasodilatation ( flushing ) , headache , and dizziness , which occurred in 14.3 per cent , 6.3 per cent , and 6.3 per cent of patients respectively . All events were mild in nature . CONCLUSIONS Sildenafil is a safe and effective treatment for erectile dysfunction of broad-spectrum etiology in Thai men . Its efficacy appears similar to that reported in other studies in Western population
For common outcomes there was similar efficacy between PDE-5 inhibitors
Background There are no r and omised and properly blinded trials directly comparing one PDE-5 inhibitor with another in a normal home setting .
Valid indirect comparisons with a common comparator must examine equivalent doses , similar duration , similar population s , with the same outcomes reported in the same way .