Levels of other adipocytokines were not significantly affected .
CONCLUSION Eicosapentaenoic acid and docosahexaenoic acid supplementation may increase adiponectin and reduce TNF-α levels in this population group .
BACKGROUND The objective of this systematic review and meta- analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals .
Supplementation with n3 fatty acid ethyl esters increases large and small artery elasticity in obese adults on a weight loss diet.
Increased arterial stiffness is associated with enhanced risk of cardiovascular disease in obese individuals . Whether n3 fatty acid ethyl ester ( FAEE ) supplementation improves arterial stiffness in obese participants on a weight loss diet has not yet been investigated . The objective of the study was to carry out a 12-wk r and omized , single-blind trial to test the effect of a 25 % energy deficit weight loss diet alone ( WL ) ( n = 12 ) or WL plus 4 g/d Omacor ( 46 % EPA and 38 % DHA ) supplementation ( WL+FAEE ) ( n = 13 ) on arterial elasticity in obese adults .  Large ( C1 ) and small artery elasticity ( C2 ) were measured by pulse contour analysis of the radial artery . WL alone reduced ( P < 0.05 in all ) body weight ( -3 % ) , waist circumference ( -4 % ) , systolic ( -3 % ) and diastolic ( -3 % ) blood pressures , cardiac output ( -4 % ) , plasma TG concentration ( -25 % ) , and the homeostasis model assessment ( HOMA ) score ( -12 % ) and increased plasma HDL cholesterol ( + 9 % ) and adiponectin ( + 18 % ) concentrations . However , WL alone did not alter C1 and C2 . The WL+FAEE intervention significantly reduced body weight ( -4 % ) , waist circumference ( -4 % ) , systolic ( -8 % ) and diastolic ( -5 % ) blood pressures , pulse pressure ( -5 % ) , heart rate ( -8 % ) , plasma TG concentration ( -36 % ) , and HOMA score ( -12 % ) and increased stroke volume ( + 3 % ) , plasma HDL cholesterol ( + 6 % ) and adiponectin concentrations ( + 28 % ) , and C1 ( + 20 % ) and C2 ( + 22 % ) artery elasticity . The changes in systolic blood pressure , heart rate , plasma TGs , C1 , and C2 were significantly greater in the WL+FAEE group than in the WL group . Supplementation with n3 FAEEs improves C1 and C2 independently of weight loss in obese adults
Levels of other adipocytokines were not significantly affected .
CONCLUSION Eicosapentaenoic acid and docosahexaenoic acid supplementation may increase adiponectin and reduce TNF-α levels in this population group .
BACKGROUND The objective of this systematic review and meta- analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals .