RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .
A double-blind ambulatory blood pressure monitoring study of the efficacy and tolerability of once-daily telmisartan 40 mg in comparison with losartan 50 mg in the treatment of mild-to-moderate hypertension in Taiwanese patients.
Ambulatory blood pressure monitoring ( ABPM ) was used to compare the efficacy and tolerability of once-daily telmisartan 40 mg and once-daily losartan 50 mg in Taiwanese patients with mild-to-moderate essential hypertension in a r and omised , double-blind , double-dummy , parallel-group study . The initial 2-week placebo run-in phase was followed by r and omisation to treatment with telmisartan 40 mg ( n = 31 ) or losartan 50 mg ( n = 30 ) for 6 weeks . The reduction in 18- to 24-h mean ( SE ) ambulatory diastolic blood pressure ( DBP ) from baseline was significantly greater with telmisartan 40 mg ( -12.1 + /- 1.6 mmHg , p = 0.036 ) than with losartan 50 mg ( -7.0 + /- 1.8 mmHg ) . The reduction in 18- to 24-h mean ( SE ) ambulatory systolic blood pressure ( SBP ) from baseline was also greater with telmisartan 40 mg ( -16.0 + /- 2.4 mmHg ) than with losartan 50 mg ( -11.8 + /- 2.7 mmHg ) , but did not achieve statistical significance . Telmisartan was well tolerated ; no serious adverse events occurred
RESULTS The global antihypertensive activity of ARB differs from that observed with amlodipine in the sense that the magnitude of the reduction in the BP values does not essentially depend on the initial BP values nor on the dose used .
When only ARB were considered , the drug used was a determinant for systolic BP reduction , whereas for diastolic BP the influence was on the BP reduction and the duration of the antihypertensive activity .
The dose used had a particular influence on the duration of the antihypertensive activity for both systolic and diastolic BP .
CONCLUSION Among the ARB , the influence is on duration more than on the magnitude of BP reduction .
Dose , therefore , is an important factor in the duration of antihypertensive activity
OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists ( ARB ) .