There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Fatty acid composition in maternal milk and plasma during supplementation with cod liver oil
Objective : We investigated how cod liver oil influences the amount of essential fatty acids in mothers ’ breast milk . Design and Intervention : Lactating mothers ( n=22 ) were r and omized into four groups 3–8 weeks after parturition . They were supplemented for 14 days with 0 , 2.5 , 5 and 10 ml cod liver oil ( 7.7 g eicosapentaenoic acid ( EPA , 20:5n-3 ) , 10.2 g docosahexaenoic acid ( DHA , 22:6n-3 ) and 22.9 g n-3 fatty acids in total per 100 ml ) . Results : In maternal plasma phospholipids there was an increase in the content of EPA and DHA in the group supplemented with 10 ml cod liver oil daily ( P≤0.05 ) . DHA concentrations in breast milk pre-supplementation ranged from 0.15 to 1.56 wt% and increased in all supplemented groups ( P≤0.05 ) . The concentration of EPA in breast milk increased in the groups supplemented with 5 or 10 ml cod liver oil ( P≤0.05 ) , whereas the concentration of arachidonic acid ( AA , 20:4n-6 ) did not change in any of the supplemented groups . Total intake of DHA adjusted to body mass index ( BMI ) , correlated to DHA concentrations in plasma ( r=0.49 , P=0.02 ) and breast milk ( r=0.45 , P=0.04 ) . The concentration of tocopherol did not change during the supplementation period , neither in plasma nor in breast milk . Conclusion : Dietary intake of DHA is reflected in the concentration of DHA in breast milk , without affecting the concentration of AA or tocopherol . Sponsorship : Supported by Peter Möller avd . av Orkla
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .