However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .
Similar effects of diets high in oleic or linoleic acids on coagulation and fibrinolytic factors in healthy humans.
BACKGROUND AND AIM Monounsaturated fatty acids ( MUFA ) have been shown to be beneficial . Their haemostatic effects , however , are poorly known . We compared the effects of oleic acid ( OA ) and linoleic acid ( LA ) on variables related with coagulation and fibrinolysis in healthy subjects . METHODS AND RESULTS Thirty-eight healthy volunteers ( 20 women , 18 men ; mean age 27 ) consumed a saturated fat baseline diet for four weeks and were then switched to either a high LA diet ( 11.5 en% ) or a high OA diet ( 18.0 en% ) for another four weeks when nearly all food was provided for the whole day . A control group of 13 subjects consumed their habitual diet throughout the study . No differences between the OA and LA diets were found in the plasma levels of fibrinogen , plasminogen activator inhibitor , antithrombin III , von Willebr and factor antigen or D-dimers . Factor FVII coagulant activity was significantly lower after the OA diet . CONCLUSIONS The results indicate largely similar effects for OA and LA on factors related with coagulation and fibrinolysis in humans . The effects of dietary fatty acid composition on FVII coagulant activity should be further studied
However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .