Criterion validity for three of these measures was established in NSCLC but not the reliability or responsiveness .
Background The measurement properties of instruments used to assess functional capacity , physical activity and muscle strength in participants with non-small cell lung cancer ( NSCLC ) have not been systematic ally review ed .
Method Objectives : To identify outcome measures used to assess these outcomes in participants with NSCLC ; and to evaluate , synthesis e and compare the measurement properties of the outcome measures identified .
Preliminary report of the 6-minute walk test as a predictor of radiation-induced pulmonary toxicity.
PURPOSE To assess the 6-minute walk test ( 6MWT ) as a predictor of  radiation therapy-induced lung injury ( RTLI ) .  METHODS AND MATERIAL S The 6MWT is a simple , economical , and reproducible test that measures both how far a person can walk in 6 min and any associated changes in vital signs . As part of a prospect i ve trial to study RTLI , a pre-RT 6MWT was performed in 41 patients . The predictive capacities of pre-RT 6MWT , forced expiratory volume in 1 s ( FEV1 ) , and single-breath diffusing capacity for carbon monoxide ( DLCO ) for the development of RTLI were assessed with receiver operating curve ( ROC ) techniques . To evaluate the 6MWT , alone or with mean lung dose ( MLD ) of radiation , as a predictor of RTLI , the rates of RTLI in patient subgroups defined by 6MWT results were compared by using Fisher 's exact test . RESULTS Thirty-one patients with > or =3 months ' follow-up were evaluable . The median baseline 6MWT result was 1400 ft . Of 31 patients , 7 developed Grade > or = 2 RTLI . Of 15 patients with an MLD > 18 Gy ( the median ) , 5 developed RTLI , compared with 2 of 16 with MLD < or = 18 Gy ( p = 0.22 ) . Among those with an MLD < or = 18 Gy , the RTLI rates were 0 of 8 and 2 of 8 for 6MWT results > or = 1400 ft or < 1400 ft , respectively , p = 0.46 . The ROC area under the curve for individual metrics was as follows : FEV1 0.66 , MLD 0.70 , DLCO 0.61 , and 6MWT 0.47 . Combining FEV1 with 6MWT increased the ROC to 0.71 , suggesting that the ratio might be a better predictor than the individual values . Patients with a high 6MWT/FEV1 ratio had a lower rate of RTLI than those with a relatively low ratio . CONCLUSIONS The 6MWT might provide prognostic information beyond pulmonary function tests and dosimetric parameters in predicting RTLI . Additional work is needed to better assess the utility of these functional metrics
Criterion validity for three of these measures was established in NSCLC but not the reliability or responsiveness .
Background The measurement properties of instruments used to assess functional capacity , physical activity and muscle strength in participants with non-small cell lung cancer ( NSCLC ) have not been systematic ally review ed .
Method Objectives : To identify outcome measures used to assess these outcomes in participants with NSCLC ; and to evaluate , synthesis e and compare the measurement properties of the outcome measures identified .