Conclusion Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes .
Due to some limitations in this study , further studies are needed to reach a definitive conclusion about the effect of n-3 PUFAs on the levels of leptin and adiponectin in T2DM
Abstract Aim N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines .
Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes , we conducted a systematic review and meta- analysis study of r and omized placebo-controlled clinical trials that examined the effects of n-3 PUFAs on serum levels of leptin and adiponectin in patients with type 2 diabetes .
Docosahexaenoic Acid-Rich Fish Oil Supplementation Improves Body Composition without Influence of the PPARγ Pro12Ala Polymorphism in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Background : The aims of this research were to investigate ( 1 ) the impact of docosahexaenoic acid (DHA)-rich fish oil supplementation on body composition , plasma adiponectin level , and peroxisome proliferator-activated receptor γ ( PPARγ ) gene expression , and ( 2 ) whether the effect of DHA-rich fish oil supplementation on the aforementioned variables is modulated by PPARγ Pro12Ala polymorphism . Methods : We genotyped PPARγ Pro12Ala polymorphism in subjects with type 2 diabetes mellitus ( T2DM ) . Ala carriers and non-Ala carriers were r and omly assigned to DHA-rich fish oil or placebo intake for 8 weeks . Results : Glycemic control was not affected by the intervention . The supplementation with DHA-rich fish oil decreased waist circumference ( p < 0.001 ) , body fat mass ( p = 0.01 ) , body fat percent ( p = 0.04 ) , and visceral fat rating ( p = 0.02 ) as well as trunk fat mass ( p = 0.04 ) . Weight , body mass index , fat-free mass , adiponectin level , and PPARγ gene expression changes showed no significant difference . No gene-diet interaction was found on body composition , adiponectin level , and PPARγ gene expression . Conclusions : DHA-rich fish oil supplementation favorably modulated body composition in patients with T2DM and could be useful to reduce visceral obesity . However , the PPARγ Pro12Ala polymorphism did not influence the changes in the desired variables
Conclusion Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes .
Due to some limitations in this study , further studies are needed to reach a definitive conclusion about the effect of n-3 PUFAs on the levels of leptin and adiponectin in T2DM
Abstract Aim N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines .
Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes , we conducted a systematic review and meta- analysis study of r and omized placebo-controlled clinical trials that examined the effects of n-3 PUFAs on serum levels of leptin and adiponectin in patients with type 2 diabetes .