Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults , results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters .
This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect
This systematic review aims to evaluate r and omised controlled trials ( RCTs ) investigating the effect of vitamin D supplementation on  endothelial function and inflammation in adults .
Effects of vitamin D on cardiovascular disease risk factors in polycystic ovary syndrome women with vitamin D deficiency
Background : Vitamin D deficiency is prevalent among women , including patients with polycystic ovary syndrome ( PCOS ) . Some studies have suggested that vitamin D may have a role in cardiovascular disease ( CVD ) . There is very limited data on the vitamin D effect on CVD risk factors in women with PCOS and vitamin D deficiency . Aim : To investigate the effect of cholecalciferol on CVD risk factors in PCOS women with vitamin D deficiency . Methods : The study was a r and omized , placebo-controlled , double blinded trial . Fifty PCOS women with vitamin D deficiency ( vitamin D , no.=24 ; placebo , no.=26 ) aged 20–40 yr , were r and omly assigned to receive 3 oral capsules of 50 , 000 IU vitamin D3 or a placebo ( one capsule every 20 days ) for two months . Serum vitamin D , PTH , lipid profile , apolipoprotein AI ( APO-AI ) , and high sensitive C- reactive protein ( hs-CRP ) were measured at baseline and after treatment . Results : Vitamin D3 therapy in PCOS patients , increased serum vitamin D ( 7.00±2.80 to 22.9±6.14 ng/ml ) , decreased serum total cholesterol ( 196.6±32.8 to 179.1±34.1 mg/dl ) , triglyceride ( 156.8±73.0 to 130.5±56.5 mg/dl ) , and VLDL ( 31.4±14.6 to 26.1 ±11.3 mg/dl ) levels significantly ( p<0.05 ) , but it did not affect serum HDL-cholesterol , LDL-cholesterol , APO-AI , and hs-CRP concentrations . There was no change in variables in the placebo group . Conclusions : Our study showed that vitamin D3 therapy had beneficial effects on some CVD risk factors in PCOS patients with vitamin D deficiency . The trial was registered at I RCT .ir ( I RCT 138904113140N2 )
Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults , results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters .
This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect
This systematic review aims to evaluate r and omised controlled trials ( RCTs ) investigating the effect of vitamin D supplementation on  endothelial function and inflammation in adults .