Conclusion The systematic review and meta- analysis support that probiotics are superior to placebo in NAFLD patients and could be utilized as a common complementary therapeutic approach
Background and Aims Probiotics was considered as a potential therapy for nonalcoholic fatty liver disease ( NAFLD ) without approval and comprehensive assessment in recent years , which call for a meta- analysis .
Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls
Background . Ectopic fat deposition in the pancreas and its relationship with hepatic steatosis and insulin resistance have not been compared between patients with nonalcoholic fatty liver disease ( NAFLD ) and healthy controls . Aim . Using a novel magnetic resonance imaging ( MRI ) based biomarker , the proton-density-fat-fraction ( MRI-PDFF ) , we compared pancreatic fat content in patients with biopsy-proven NAFLD to healthy controls and determined whether it is associated with insulin resistance and liver fat content . Methods . This nested case-control study was derived from two prospect i ve studies including 43 patients with biopsy-proven NAFLD and 49 healthy controls who underwent biochemical testing and MRI .  Results . Compared to healthy controls , patients with NAFLD had significantly higher pancreatic MRI-PDFF ( 3.6 % versus 8.5 % , P value < 0.001 ) , and these results remained consistent in multivariable-adjusted models including age , sex , body mass index , and diabetes ( P value = 0.03 ) . We found a strong correlation between hepatic and pancreatic MRI-PDFF ( Spearman correlation , P = 0.57 , P value < 0.001 ) . Participants with increased insulin resistance determined by homeostatic-model-of-insulin-resistance ( HOMA-IR ) greater than 2.5 had higher pancreatic ( 7.3 % versus 4.5 % , P value = 0.015 ) and liver ( 13.5 % versus 4.0 % , P value < 0.001 ) MRI-PDFF . Conclusion . Patients with NAFLD have greater pancreatic fat than normal controls . Insulin resistance is associated with liver and pancreatic fat accumulation
Conclusion The systematic review and meta- analysis support that probiotics are superior to placebo in NAFLD patients and could be utilized as a common complementary therapeutic approach
Background and Aims Probiotics was considered as a potential therapy for nonalcoholic fatty liver disease ( NAFLD ) without approval and comprehensive assessment in recent years , which call for a meta- analysis .