Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effect of vitamin D supplementation on bone health parameters of healthy young Indian women
Summary There is a huge prevalence of hypovitaminosis D in the Indian population . We studied the efficacy and safety of oral vitamin D supplementation in apparently healthy adult women . Monthly cholecalciferol given orally , 60,000 IU/month during summers and 120,000 IU/month during winters , safely increases 25-hydroxyvitamin D ( 25(OH)D ) levels to near normal levels . Introduction There is a huge burden of hypovitaminosis D in the Indian population . The current recommendation for vitamin D supplementation is not supported by sufficient evidence . Methods Study subjects included 100 healthy adult women of reproductive age group from hospital staff . They were r and omized into group A ( control ) and group B ( supplement ) by simple r and omization . Group B received 60,000 IU of cholecalciferol/month administered orally for 3 months , and then group A received 60,000 IU and group B 120,000 IU/month for 6 months . Results Mean baseline 25(OH)D level was 4.5 ± 3.1 ng/ml and parathyroid hormone level was 50 ± 25 pg/ml . In group B , 25(OH)D levels increased from 4.8 ± 3.5 to 31.6 ± 15.5 ng/ml ( P < 0.001 ) in 3 months . Interestingly , the increase , although of lower magnitude , was also observed in control group A , from 4.5 ± 3.4 ng/ml ( in spring ) to 10.8 ± 7.2 ng/ml ( in summer ; P < 0.001 ) . In group A ( 60,000 IU/month ) , mean 25(OH)D level had increased to 22.3 ± 12.4 ng/ml ( P < 0.001 ) at 9 months ( winter ) . In group B ( 120,000 IU/month ) , 25(OH)D levels were maintained at 30.7 ± 12.8 ng/ml at 9 months ( winter ) . Conclusion Our data show that monthly administration of 60,000 IU cholecalciferol in healthy subjects with hypovitaminosis D may suffice in summer months , but higher doses may be more appropriate during winter months
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .