DISCUSSION Although cannabinoids are now being used to manage different pain conditions , the evidence for the clinical effects are unclear .
INTRODUCTION Pain is a frequent clinical symptom with significant impact on the patient 's well-being .
Therefore , adequate pain management is of utmost importance .
While cannabinoids have become a more popular alternative to traditional types of pain medication among patients , the quality of evidence supporting the use of cannabinoids has been question ed .
The beneficial and harmful effects of cannabinoids in patients with pain is unknown .
Accordingly , we aim to assess the efﬁcacy , tolerability and safety of cannabinoids ( herbal , plant-derived extracts and synthetic ) compared with placebo or no intervention for any type of pain .
Changes in the SF-36 in 12 months in a clinical sample of disadvantaged older adults.
OBJECTIVES The present study assessed changes in the Medical Outcomes Study 36-item short-form health survey ( SF-36 )  during a 12-month period and examined the relation of those changes to selected baseline characteristics . METHODS The study was a 12-month follow-up evaluation of 786 disadvantaged adults aged 50 to 99 years old who had participated in a r and omized controlled clinical trial in the general medicine outpatient clinics of a major academic medical center . Descriptive and psychometric analyses of changes in the SF-36 scale scores during a 12-month period were performed , and two series of multivariable logistic regressions of increases or decreases greater than one st and ard error of measurement ( SEM ) versus stability on selected baseline characteristics were done . Measures were the eight SF-36 scales . RESULTS Mean baseline scores on the SF-36 scales were substantially below age-specific national norms . Problematic floor and /or ceiling effects were found for the bodily pain , social function , role -- physical , and role -- emotional scales , consistent with age-specific national norms . Internal consistency was unacceptable for the general health perceptions scale , adequate for the social function scale , and good for all the other SF-36 scales . Improvements greater than one st and ard error of measurement were found for between one fifth and one third of the patients , and declines greater than one st and ard error of measurement were found for between one fifth and one third of the patients . Selected baseline characteristics generally were unrelated to either improvements or declines on the SF-36 scales . CONCLUSIONS The SF-36 scales appear to be sufficiently sensitive for measuring changes in health outcomes during a 1-year period in older patients with debilitating disease . Little of the measured change , however , was predictable
DISCUSSION Although cannabinoids are now being used to manage different pain conditions , the evidence for the clinical effects are unclear .
INTRODUCTION Pain is a frequent clinical symptom with significant impact on the patient 's well-being .
Therefore , adequate pain management is of utmost importance .
While cannabinoids have become a more popular alternative to traditional types of pain medication among patients , the quality of evidence supporting the use of cannabinoids has been question ed .
The beneficial and harmful effects of cannabinoids in patients with pain is unknown .
Accordingly , we aim to assess the efﬁcacy , tolerability and safety of cannabinoids ( herbal , plant-derived extracts and synthetic ) compared with placebo or no intervention for any type of pain .