Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .
The Day-to-Day Acute Effect of Wake Therapy in Patients with Major Depression Using the HAM-D6 as Primary Outcome Measure: Results from a Randomised Controlled Trial
Background This paper reports day-to-day data for from a one-week intervention phase , part of a 9-weeks r and omised parallel study with patient having major depression ( data from weekly visits have been reported ) . Wake therapy ( sleep deprivation ) has an established antidepressant effect with onset of action within hours . Deterioration on the following night ’s sleep is , however , common , and we used daily light therapy and sleep time stabilisation as a preventive measure . In particular , we evaluated the day-to-day acute effect of and tolerance to sleep deprivation and examined predictors of response . Methods Patients were assessed at psychiatric inpatient wards . In the wake group ( n = 36 ) , patients did three wake therapies in combination with light therapy each morning together with sleep time stabilisation . In the exercise group ( n = 38 ) , patients did daily exercise .  Hamilton subscale scores were primary outcome ( not blinded ) , secondary outcome was self- assessment data from the Preskorn scale and sleep . Results Patients in the wake therapy group had an immediate , large , stable , and statistically significant better antidepressant effect than patients in the exercise group with response rates at day5 of 75.0%/25.1 % and remission rates of 58.6%/6.0 % , respectively . The response and remission rates were diminished at day8 with response rates of 41.9%/10.1 % and remission rates of 19.4%/4.7 % , respectively . Patients and ward personnel found the method applicable with few side effects . Positive diurnal variation ( mood better in the evening ) predicted a larger response to wake therapy . In the wake group napping on days after intervention predicted greater deterioration on day8 . Conclusions The intervention induced an acute antidepressant response without relapse between wake nights but with a diminishing effect after intervention . Development is still needed to secure maintenance of response . Avoiding napping in the days after wake therapy is important . Trial Registration Clinical trials.gov
Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .