In conclusion , statins were effective in preventing postoperative adhesion , as assessed based on gross and microscopic adhesion scores in rats
Adhesion is a significant concern after surgery .
Many research ers studied the anti-adhesive effect of statin , of which results were inconsistent .
Thus , we purpose d to perform a systematic review and meta- analysis to evaluate the effect of statins on postoperative adhesion in an experimental study .
Effects of Intraperitoneal Administration of Simvastatin in Prevention of Postoperative Intra-abdominal Adhesion Formation in Animal Model of Rat.
OBJECTIVE To determine the preventive effects of local administration of simvastatin for postoperative intra-abdominal adhesion formation in animal model of rat . METHODS In this experimental study , 32 Wistar albino rats as the animal model of intra-abdominal adhesion formation were included . Adhesions were induced in all the animals via abrasion of the peritoneal and intestinal surface during laparotomy . Afterwards , the rats were r and omly assigned to receive simvastatin ( 30 mg/kg body weight ) as a single intraperitoneal dose at the time of laparotomy ( n=16 ) or normal saline in same volume at the same time ( n=16 ) . At the day 21 , animals were euthanized and the adhesions were quantified clinical ly ( via repeated laparotomy ) and pathologically and compared between the two groups . RESULTS The baseline characteristics of the animals were comparable between two study groups . Clinical ly , in simvastatin group , 10 rats ( 62.5 % ) did not develop any adhesion and 6 ( 37.5 % ) had first- grade adhesion ; whereas in the control group , 11 ( 68.8 % ) rats had first- and 5 ( 31.2 % ) had second- grade adhesions ( p<0.001 ) . Pathologically , in simvastatin group , 6 rats ( 37.5 % ) had first- grade adhesion , while in control group , 11 rats ( 68.8 % ) had first- and 5 ( 31.2 % ) had second- grade adhesions ( p<0.001 ) . CONCLUSION Our findings suggest that intraperitoneal administration of simvastatin is an effective method for prevention of postoperative intra-abdominal adhesion formation in animal model of rat
In conclusion , statins were effective in preventing postoperative adhesion , as assessed based on gross and microscopic adhesion scores in rats
Adhesion is a significant concern after surgery .
Many research ers studied the anti-adhesive effect of statin , of which results were inconsistent .
Thus , we purpose d to perform a systematic review and meta- analysis to evaluate the effect of statins on postoperative adhesion in an experimental study .