Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .
Daily intake of vitamin D- or calcium-vitamin D-fortified Persian yogurt drink (doogh) attenuates diabetes-induced oxidative stress: evidence for antioxidative properties of vitamin D.
BACKGROUND Both poor vitamin D status and oxidative stress ( OS ) have been independently associated with late diabetic complications , including cardiovascular disease ( CVD ) . The present study aim ed to examine the effect of daily intake of vitamin D alone or in combination with calcium as a fortified Persian yogurt drink ( doogh ) on OS over 12 weeks . METHODS Ninety patients with type 2 diabetes aged 30 - 50 years from both sexes were r and omly allocated to one of the three groups to receive two 250-mL bottles of doogh a day , which was either plain ( PD ; containing 150 mg per 250 mL of calcium and no detectable vitamin D ) , vitamin D-fortified ( DD ; containing 150 mg of calcium + 500 IU vitamin D per 250 mL ) or calcium-vitamin D-fortified ( CDD ; 250 mg od calcium + 500 IU vitamin D per 250 mL ) . RESULTS Although mean ( SD ) serum concentrations of protein carbonyl significantly decreased in both DD and CDD groups [ -2.07 ( 4.39 ) nm , P = 0.015 and -4.4 ( 7.64 ) nm , P = 0.003 , respectively ] , the change in PD group was not significant [ -0.54 ( 6.96 ) nm , P = 0.674 ] . A similar pattern was observed for cardiac myeloperoxidase [ PD : -19.4 ( 75.9 ) μg L(-1 ) , P = 0.173 ; DD : -21.8 ( 54.2 ) μg L(-1 ) , P = 0.035 , CDD : -48.5 ( 76.9 ) μg L(-1 ) , P = 0.002 ] . Superoxide dismutase increased significantly only in DD and CDD [ 56.9 ( 74.0 ) U L(-1 ) , P < 0.001 and 51.6 ( 119.9 ) U L(-1 ) , P = 0.025 , respectively ] . Changes of serum advanced glycation end-products showed a significant between-group difference among PD , DD and CDD [ 239.4 ( 388.4 ) U L(-1 ) , -58.1 ( 147.6 ) U L(-1 ) and -143.7 ( 475.9 ) U L(-1 ) × 10(3 ) , respectively , P = 0.003 ] , which remained significant after controlling for changes of fasting serum glucose ( P = 0.013 ) and glycated haemoglobin ( P = 0.015 ) . CONCLUSIONS The findings of the present study demonstrated an OS attenuating effect of vitamin D. However , extra calcium did not convey additional benefit
Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .