Once-daily dihydropyridine calcium channel blockers appeared to lower blood pressure by a relatively constant amount throughout the 24-hour dosing interval .
Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours .
BACKGROUND Calcium channel blockers are a heterogeneous class of drugs , including dihydropyridine and non-dihydropyridine subgroups , commonly used in the treatment of hypertension .
A systematic review of the 24-hour time course of the blood pressure-lowering effect has not been published .
OBJECTIVES To assess how much variation there is in hourly systolic and diastolic blood pressure lowering by dihydropyridine calcium channel blockers over a 24-hour period in people with hypertension aged 18 years or over , with baseline systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg , or both .
The effect of amlodipine on ambulatory blood pressure in hypertensive patients.
Certain high-risk population s , such as diabetics and blacks , have sustained elevation in blood pressure and heart rate throughout the day and night , with blunting of the usual diurnal variability pattern . This may contribute to their higher incidence of left ventricular hypertrophy ( blacks ) and cardiovascular complications ( diabetics ) . Hypertensives who maintain a diurnal pattern of blood pressure variation still exhibit higher daytime and nocturnal blood pressure levels than normotensives . Thus , to achieve maximum effectiveness in treating hypertension , 24-hour control of blood pressure is necessary . Antihypertensive agents should effectively reduce blood pressure consistently throughout a 24-hour period . The objective of this study was to assess the effects of amlodipine , 5 mg once daily , on blood pressure measured by 24-hour ambulatory monitoring in a r and omized , double-blind , placebo-controlled single-site study . Patients with mild-to-moderate essential hypertension were r and omized to receive amlodipine ( n = 11 ) or placebo ( n = 5 ) in a 2:1 ratio . A 4-week single-blind placebo run-in period was followed by a 4-week double-blind phase . Ambulatory monitoring of blood pressure was carried out for 24 hours at the end of each 4-week phase . Patients receiving amlodipine had significantly lower blood pressure compared with placebo 24 hours after the last dose ( supine blood pressure -25.1/-10.1 mm Hg ; st and ing blood pressure -21.2/-9.7 mm Hg ) after 4 weeks of treatment . This effect was clearly demonstrated by the 24-hour postdose measurement and the mean blood pressure over the 24-hour interval as measured by ambulatory recordings . ( ABSTRACT TRUNCATED AT 250 WORDS
Once-daily dihydropyridine calcium channel blockers appeared to lower blood pressure by a relatively constant amount throughout the 24-hour dosing interval .
Six dihydropyridine calcium channel blockers studied in this review lowered blood pressure by a relatively similar amount each hour over the course of 24 hours .
BACKGROUND Calcium channel blockers are a heterogeneous class of drugs , including dihydropyridine and non-dihydropyridine subgroups , commonly used in the treatment of hypertension .
A systematic review of the 24-hour time course of the blood pressure-lowering effect has not been published .
OBJECTIVES To assess how much variation there is in hourly systolic and diastolic blood pressure lowering by dihydropyridine calcium channel blockers over a 24-hour period in people with hypertension aged 18 years or over , with baseline systolic blood pressure of at least 140 mmHg or diastolic blood pressure of at least 90 mmHg , or both .