Conclusions The current evidence is not sufficiently strong to verify a preventive role of probiotics in AR , but probiotics may improve the overall quality of life and nasal symptom scores .
Background Allergic rhinitis ( AR ) is a disease of respiratory allergy , and probiotics can provide a potential strategy for its management .
The purpose of this study was to carry out a systematic review to investigate the role of probiotics in the prevention and treatment of AR .
Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study.
Studies in animals have suggested that lactic acid bacteria alleviate allergic diseases , however , little information is available on their clinical effect on allergy in humans . Thus , we examined the efficacy of orally administered Lactobacillus acidophilus strain L-92 ( L-92 ) on perennial allergic rhinitis . In a r and omized , double-blind , placebo-controlled clinical trial , 49 patients with perennial allergic rhinitis were r and omized to receive either 100 mL of heat-treated fermented milk containing L-92 ( n = 25 ) or acidified milk without lactic acid bacteria ( placebo ; n = 24 ) for 8 wk . The severity of symptoms was evaluated based on the changes in the scores of clinical symptoms . Oral administration of milk fermented with L-92 result ed in a statistically significant improvement of nasal symptom-medication scores . Ocular symptom-medication scores of patients in the L-92 intervention group tended to improve compared with those in the placebo group . In addition , clear decreases of the scores of swelling and color of the nasal mucosa were observed in the L-92 intervention group at 6 and 8 wk after the start of ingestion of fermented milk . There were no significant differences in serum antihouse dust mite immunoglobulin E levels nor in T helper type 1/T helper type 2 ratio between the 2 groups . These results suggest that oral administration of L-92 can alleviate the symptoms of perennial allergic rhinitis , however , statistically significant changes were not shown in blood parameters
Conclusions The current evidence is not sufficiently strong to verify a preventive role of probiotics in AR , but probiotics may improve the overall quality of life and nasal symptom scores .
Background Allergic rhinitis ( AR ) is a disease of respiratory allergy , and probiotics can provide a potential strategy for its management .
The purpose of this study was to carry out a systematic review to investigate the role of probiotics in the prevention and treatment of AR .