No alteration in plasma IL-6 concentration was observed .
Pentoxifylline did not alter BP or plasma IL-6 concentration , but significantly reduced circulating TNF-α and CRP concentrations
INTRODUCTION Pentoxifylline is a xanthine derivative with potential cardiovascular benefits .
AIM To evaluate the impact of pentoxifylline on  blood pressure ( BP )  and plasma TNF-α , C-reactive protein ( CRP ) and IL-6 through a systematic review and meta- analysis of r and omized controlled trials .
Effects of pentoxifylline on the cytokines that may play a role in rejection and resistive index in renal transplant recipients.
Pentoxifylline ( PTX ) is a nonselective phosphodiesterase inhibitor that inhibits the production of TNFalpha and IL6 and IL-10 cytokines . In renal rejection TNFalpha , IL-6 , and IL-10 may have important roles . In this study , 22 renal transplant recipients treated with tacrolimus , prednisolone , and mycophenolate mofetil  were prescribed PTX ( 2 x 600 mg/d ) for 3 months ( GI ) , and 20 similar patients not receiving PTX  were used as controls ( GII ) . Stable subjects whose serum creatinine was lower than 1.8 mg/dL and were more than 6 months posttransplant , were enrolled into this study if the blood pressure was well controlled and there was no  diabetes mellitus , infection , or  inflammation . At the end of 3 months TNF-alpha decreased from 4.2 + /- 2.1 to 2.4 + /- 0.7 ( P = .001 ) and 4.0 + /- 2.2 to 3.9 + /- 1.7 ( P = .718 ) , IL-10 also decreased from 3.90 + /- 1.9 to 2.38 + /- 0.6 ( P = .001 ) and 4.02 + /- 1.6 to 3.82 + /- 1.5 ( P = .225 ) in GI and GII , respectively . For IL-10 and TNF-alpha the alterations between baseline and the last visit of GI and GII were significant ( P < .002 for all ) . Resistive index ( RI ) decreased in GI but the difference in alterations between baseline and the last visit of GI and GII was marginal . In summary IL-10 and TNF-alpha levels decreased in stable recipients treated with PTx . RI also decreased marginally secondary to PTx treatment . PTx was well tolerated and free side effects .  PTx did not affect tacrolimus levels or other biochemical and hematological parameters
No alteration in plasma IL-6 concentration was observed .
Pentoxifylline did not alter BP or plasma IL-6 concentration , but significantly reduced circulating TNF-α and CRP concentrations
INTRODUCTION Pentoxifylline is a xanthine derivative with potential cardiovascular benefits .
AIM To evaluate the impact of pentoxifylline on  blood pressure ( BP )  and plasma TNF-α , C-reactive protein ( CRP ) and IL-6 through a systematic review and meta- analysis of r and omized controlled trials .