Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .
Establishing the cut-off score for remission and severity-ranges on the Psychotic Depression Assessment Scale (PDAS).
BACKGROUND The Psychotic Depression Assessment Scale ( PDAS ) is a rating scale dedicated to the measurement of severity in psychotic depression ( PD ) . The aim of this study was to establish the PDAS cut-off for remission of PD as well as PDAS score-ranges for mild , moderate , and severe PD . The secondary aim was to test how remission , as defined by the PDAS , would perform as outcome measure when applied to the data from a large r and omized controlled trial ( RCT ) in PD . METHODS The study was based on data from the Study of Pharmacotherapy in Psychotic Depression ( STOP-PD ) . The cut-off for remission on the PDAS and the severity-ranges for mild , moderate , and severe PD were defined using the Clinical Global Impression - Severity scale ( CGI-S ) as reference by means of pair-wise receiver operating characteristic ( ROC ) analyses . Subsequently , it was tested whether remission on the PDAS could separate the effects of Olanzapine+Sertraline vs. Olanzapine+Placebo through an intention-to-treat , mixed-effects logistic regression of the data from STOP-PD . RESULTS According to the ROC analyses , the ideal cut-off for remission of PD was a PDAS total score < 8 , while the severity-ranges for mild , moderate and severe PD were 8 - 15 , 16 - 23 , and > 23 respectively . When applying the PDAS total score < 8 ( remission ) as outcome on the STOP-PD data , treatment with Olanzapine+Sertraline performed significantly better than Olanzapine+Placebo ( p<0.001 ) . LIMITATIONS The STOP-PD was not design ed specifically to answer the research questions of the present study . CONCLUSIONS According to this study , a total score < 8 on the PDAS corresponds to remission of PD
Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .