Conclusions Compared to the placebo or manual reduction method , the topical steroid therapy is more effective in the treatment of phimosis in children .
Although there is still controversy in the different type and dosage of steroid , this could be used against phimosis before circumcision
Abstract Purpose We evaluated a systematic review on the therapeutic efficacy of topical steroids in children with phimosis to provide data for the clinical options of pediatric phimosis .
Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial.
PURPOSE To compare the efficacy of three different formulations containing Betamethasone Valerate versus placebo in the topical treatment of phimosis . As a secondary goal , we compared the outcomes after 30 and 60 days of treatment . MATERIAL S AND METHODS Two hundred twenty boys aged 3 to 10 years old with clinical diagnosis of phimosis were enrolled . Patients were r and omized to one of the following groups : Group 1 : Betamethasone Valerate 0.2 % plus Hyaluronidase ; Group 2 : Betamethasone Valerate 0.2 % ; Group 3 : Betamethasone Valerate 0.1 % or Group 4 : placebo . Parents were instructed to apply the formula twice a day for 60 days and follow-up evaluations were scheduled at 30 , 60 and 240 days after the first consultation . Success was defined as complete and easy foreskin retraction . RESULTS One hundred ninety-five patients were included at our final analysis . Group 1 ( N = 54 ) , 2 ( N = 51 ) and 3 ( N = 52 ) had similar success and improvement rates , all treatment groups had higher success rates than placebo ( N = 38 ) . After 60 days of treatment , total and partial response rates for Groups 1 , 2 and 3 were 54.8 % and 40.1 % , respectively , while placebo had a success rate of 29 % . Success and improvement rates were significantly better in 60 days when compared to 30 days . CONCLUSIONS Betamethasone Valerate 0.1 % , 0.2 % and 0.2 % in combination with Hyaluronidase had equally higher results than placebo in the treatment of phimosis in boys from three to ten years-old . Patients initially with partial or no response can reach complete response after 60 days of treatment
Conclusions Compared to the placebo or manual reduction method , the topical steroid therapy is more effective in the treatment of phimosis in children .
Although there is still controversy in the different type and dosage of steroid , this could be used against phimosis before circumcision
Abstract Purpose We evaluated a systematic review on the therapeutic efficacy of topical steroids in children with phimosis to provide data for the clinical options of pediatric phimosis .