The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
Clinical effect of a triclosan-containing dentifrice on plaque and gingivitis: a six-month study.
A total of 294 adult male and female subjects completed a 6-month , double-blind clinical trial design ed to evaluate the effects of a dentifrice which contained 0.3 % triclosan in conjunction with 2 % of a methoxyethylene/maleic acid copolymer in a 0.243 % sodium fluoride/silica base , relative to a control dentifrice , on  supragingival plaque accumulation and gingivitis .  Plaque and gingivitis were scored after 3 and 6-month use of the assigned dentifrice . At the end of the study , the triclosan group showed an average reduction , relative to the control group , of 12 % in plaque accumulation and 20 % in gingivitis . Both were statistically significant at p < or = 0.0001 . The effect of the triclosan dentifrice was most pronounced on the more severe manifestations of plaque and gingivitis . The improvement in the gingival parameters at 6-months relative to the control dentifrice was statistically significant at p < or = 0.0001 . It was concluded that the twice-daily use of the triclosan-containing dentifrice result ed in significant reduction in supragingival plaque formation and a significant improvement in gingival health without the presence of any extrinsic staining or objectionable taste
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .