Conclusion : Low folate and B12 serum levels seem to be associated with  depression in the aged .
Objectives : To systematic ally review and meta-analyse existing evidence on the association between folate/B12 , and depression among the aged people .
Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction.
This was a 4-week r and omized placebo-controlled double-blind study to assess augmentation of open tricyclic antidepressant treatment with 10 mg each of vitamins B1 , B2 , and B6 in 14 geriatric in patients with depression . The active vitamin group demonstrated significantly better B2 and B6 status on enzyme activity coefficients and trends toward greater improvement in scores on ratings of depression and congnitive function , as well as in serum nortriptyline levels compared with placebo-treated subjects ( Ss ) . Without specific supplementation , B12 levels increased in Ss receiving B1/B2/B6 and decreased in placebo Ss . These findings offer preliminary support for further investigation of B complex vitamin augmentation in the treatment of geriatric depression
Conclusion : Low folate and B12 serum levels seem to be associated with  depression in the aged .
Objectives : To systematic ally review and meta-analyse existing evidence on the association between folate/B12 , and depression among the aged people .