Findings and Conclusion To our knowledge , this is the first meta- analysis to compare the clinical results between PAT and a control in joint replacement patients .
This meta- analysis has proven that the use of a PAT reinfusion system reduced significantly the dem and for ABT , the number of patients who require ABT and the cost of hospitalization after total knee and hip arthroplasty .
This study , together with other previously published data , suggests that PAT drains are beneficial .
Background Total hip or knee arthroplasty is an elective procedure that is usually accompanied by substantial blood loss , which may lead to acute anemia .
As a result , almost half of total joint arthroplasty patients receive allogeneic blood transfusions ( ABT ) .
Many studies have shown that post-operative auto-transfusion ( PAT ) significantly reduces the need for  ABT  , but other studies have question ed the efficacy of this method .
Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty
Purpose : To determine whether salvaged autologous blood collected postoperatively contains complement split products ( SC5b-9 ) , and pro-inflammatory cytokines ( IL-6 and IL-8 ) and whether there are any differences between blood collected during hip or knee surgery . Methods : Fifty-eight consecutive patients undergoing hip or knee replacement surgery were studied . Thirty-eight had postoperative bleeding large enough to require infusion of salvaged blood . The salvaged blood was filtered during collection through a 200 µm filter and before infusion a 40 µm filter was used . Sample s for complement and cytokine determinations were drawn from the circulation and from the collected blood . Results : High concentrations of SC5b-9 , IL-6 , and IL-8 were found in salvaged blood . The concentrations were higher than in the circulation ( P<0.05 ) . The circulating concentrations of IL-6 and IL-8 were increased 60 min and 12–18 hr after transfusion . There were no differences regarding SC5B-9 , IL-6 , and IL-8 in the blood collected after hip or knee surgery . Conclusion : Blood collected from a surgical wound contains large concentrations of inflammatory mediators . There were no differences between blood collected during hip or knee surgery . RésuméObjectif : Déterminer si la récupération postopératoire de sang autologue contient des produits de dégradation du complément ( SC 5b-9 ) et des cytokines pro-inflammatoires ( IL-6 et IL-8 ) , et s’il y a des différences avec le sang prélevé pendant l’opération de la hanche ou du genou . Méthode : L’étude a porté sur 58 patients successivement admis pour la mise en place d’une prothèse de hanche ou du genou . Chez 38 d’entre eux , les pertes sanguines postopératoires ont été assez importantes pour nécessiter la transfusion de sang récupéré . Ce sang a été filtré pendant le prélèvement avec un filtre de 200 µm et avant la transfusion avec un filtre de 40 µm . Des échantillons retenus de la circulation et du sang récupéré ont servi à déterminer la cytokine et le complément . Résultats : De fortes concentrations de SC5B-9 , IL-6 et IL-8 ont été trouvées dans le sang récupéré . Elles étaient plus élevées que celles de la circulation ( P<0,05 ) . Les concentrations circulantes de IL-6 et de IL-8 ont augmenté 60 min et 12–18 h après la transfusion . Aucune différence n’a été enregistrée concernant les SC5b-9 , IL-6 et IL-8 dans le sang prélevé après l’opération de hanche ou du genou . Conclusion : Le sang prélevé au site d’incision chirurgicale contient de gr and es concentrations de médiateurs de l’inflammation . Ce sang ne présente pas de différence avec celui qui est prélevé pendant une opération de hanche ou du genou
Findings and Conclusion To our knowledge , this is the first meta- analysis to compare the clinical results between PAT and a control in joint replacement patients .
This meta- analysis has proven that the use of a PAT reinfusion system reduced significantly the dem and for ABT , the number of patients who require ABT and the cost of hospitalization after total knee and hip arthroplasty .
This study , together with other previously published data , suggests that PAT drains are beneficial .
Background Total hip or knee arthroplasty is an elective procedure that is usually accompanied by substantial blood loss , which may lead to acute anemia .
As a result , almost half of total joint arthroplasty patients receive allogeneic blood transfusions ( ABT ) .
Many studies have shown that post-operative auto-transfusion ( PAT ) significantly reduces the need for  ABT  , but other studies have question ed the efficacy of this method .