The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
The clinical efficacy of Colgate Total Plus Whitening Toothpaste containing a special grade of silica and Colgate Total Fresh Stripe Toothpaste in the control of plaque and gingivitis: a six-month clinical study.
The objective of this six-month , placebo-controlled , double-blind clinical study , conducted in harmony with American Dental Association guidelines , was to provide an assessment of the effectiveness of a new dentifrice formulation of Colgate Total Toothpaste containing a special grade of silica ( Colgate Total Plus Whitening Toothpaste ) , vs. Colgate Total Fresh Stripe Toothpaste as a control , and a placebo dentifrice without triclosan and the copolymer , for the control of supragingival dental plaque and gingivitis . Adult male and female subjects from the state of New Jersey were entered into the study , and stratified into three treatment groups which were balanced for baseline Quigley-Hein Plaque Index scores and baseline Löe-Silness Gingival Index scores . Subjects received an oral prophylaxis , and were instructed to brush their teeth twice daily ( morning and evening ) for one minute with their assigned dentifrice , using a soft-bristled toothbrush . Examinations for supragingival plaque and gingivitis were conducted after three-months ' and again after six-months ' participation in the study . One-hundred ten ( 110 ) subjects complied with the protocol and completed the entire six-month clinical study . At both the three- and six-month study examinations , the Colgate Total Plus Whitening Toothpaste group and the Colgate Total Fresh Stripe Toothpaste group exhibited statistically significantly less supragingival plaque and gingivitis than did the placebo toothpaste group . At the six-month examination , the magnitude of these differences exceeded 23.0 % for all four parameters measured in the Colgate Total Plus Whitening Toothpaste group ( 29.9 % for Plaque Index , 59.2 % for Plaque Severity Index , 23.2 % for Gingival Index , and 75.1 % for Gingivitis Severity Index ) . Also , at the six-month examination , the magnitude of these differences exceeded 21.0 % for each of the four parameters measured in the Colgate Total Fresh Stripe Toothpaste group ( 27.9 % for Plaque Index , 54.9 % for Plaque Severity Index , 21.4 % for Gingival Index and 69.2 % for Gingivitis Severity Index ) . The results of this six-month clinical study support the conclusion that Colgate Total Plus Whitening Toothpaste and Colgate Total Fresh Stripe Toothpaste provided a statistically significant , clinical ly relevant level of efficacy for the control of supragingival plaque and gingivitis , in accordance with the criteria provided by current American Dental Association guidelines
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .