EA was superior to pharmacological treatment when the treatment duration lasted for three menstrual cycles , evidence d by significantly higher curative rate .
No statistically significant differences between EA at SP6 and control groups were found regarding the VRS , RSS-COX1 , and RSS-COX2 .
The findings of our study suggested that EA can provide considerable immediate analgesia effect for PD .
Electroacupuncture ( EA ) is considered to be a promising alternative therapy to relieve the menstrual pain for primary dysmenorrhea ( PD ) , but the conclusion is controversial .
Here , we conducted a systematic review and meta- analysis specifically to evaluate the clinical efficacy from r and omized controlled trials ( RCTs ) on the use of EA in patients with PD .
[Effects of instant electroacupuncture at the different acupoints on IP3 in the uterus tissue of dysmenorrhea model rats].
OBJECTIVE To compare the effects of instant electroacupuncture ( EA ) at the different acupoints on IP3 in the uterus tissue of dysmenorrhea model rats so as to investigate the specificity of acupoints . METHODS Fifty female SD rats were r and omly divided into a saline group , a model group , a Sanyinjiao ( SF 6 ) group , a Xuehai ( SP 10 ) group and a Hegu ( LI 4 ) group , 10 rats in each group . The rats were given subcutaneous injection of Estradiol Beozoate injection for 10 consecutive days except those in the saline group , and intraperitoneal injection of 2U Oxytocin at 1 h after the last administration to create the dysmenorrhea rats model , and the saline group was given the same dose of saline every day . On the 10th day the rats in each EA group were given EA 20 min , and the rats in the saline group and model group were bound 20 min , and the writhing response was observed at the same time . The uterine IP3 contents were detected with enzyme-linked immunosorbent assay method . RESULTS ( 1 ) Compared with ( 0.311+/- 0.253 ) in the saline group , the writhing scores per minute of ( 5.867 + /- 3.442 ) in the model group and ( 2.311 + /- 0.957 ) in the Xuehai ( SP 10 ) group were both increased significantly ( P < 0.01 , P < 0.05 ) , and ( 1.833 + /- 1.355 ) in the Sanyinjiao ( SP 6 ) group and ( 0.743 + /- 0.306 ) in the Hegu ( LI 4 ) group showed no significant differences ( P > 0.05 ) . Compared with that in the model group , the writhing scores per minute decreased significantly ( all P < 0.01 ) in all the EA groups , with no significant differences among all the EA groups ( all P > 0.05 ) . ( 2 ) Compared with ( 2.698 + /- 1.491 ) ng/mg in the saline group , IP3 contents of the uterus of ( 0.813 + /- 0.899 ) ng/mg in the model group , ( 1.740 + /- 0.375 ) ng/mg in the Sanyinjiao ( SP 6 ) group and ( 0.692 + /- 0.212 ) ng/mg in the Hegu ( LI 4 ) group were all lower significantly ( P < 0.05 , P < 0.01 ) , and ( 0.743+/- 0.306 ) ng/mg in the Xuehai ( SP 10 ) group showed no significant differences ( P > 0.05 ) . Compared with that in the model group , IP3 content of the uterus in the Hegu ( LI 4 ) group showed no significant difference ( P > 0.05 ) , and those in the Sanyinjiao ( SP 6 ) group and in the Xuehai ( SP 10 ) group increased significantly ( both P < 0 05 ) , which were significantly higher than that in the Hegu ( II 4 ) group ( P < 0.05 , P < 0.01 ) . CONCLUSION There are no significant differences among the instant EA groups in improving the dysmenorrhea symptoms , but there is obvious specificity of acupoint effects in the regulation of IP3 .  Electroacupuncture at " Sanyinjiao ( SP 6 ) " Xuehai ( SP 10 ) " has more marked effect in dysmenorrhea model rats
EA was superior to pharmacological treatment when the treatment duration lasted for three menstrual cycles , evidence d by significantly higher curative rate .
No statistically significant differences between EA at SP6 and control groups were found regarding the VRS , RSS-COX1 , and RSS-COX2 .
The findings of our study suggested that EA can provide considerable immediate analgesia effect for PD .
Electroacupuncture ( EA ) is considered to be a promising alternative therapy to relieve the menstrual pain for primary dysmenorrhea ( PD ) , but the conclusion is controversial .
Here , we conducted a systematic review and meta- analysis specifically to evaluate the clinical efficacy from r and omized controlled trials ( RCTs ) on the use of EA in patients with PD .