Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .
A 5-Year Follow-Up of Antioxidant Supplementation in Type 2 Diabetic Retinopathy
Purpose This study was design ed to evaluate the effect of antioxidant supplementation on  diabetic retinopathy ( DR )  over a 5-year follow-up period . To our knowledge , this is the first such clinical trial performed . Methods We recruited 105 type 2 diabetic patients with nonproliferative DR . A complete ophthalmic checkup and a plasma determination of oxidative ( malonyldialdehyde [ MDA ] ) and antioxidant parameters ( total antioxidant status [ TAS ] ) were obtained as the baseline . One part of the cohort was r and omly assigned to oral antioxidant supplementation at nutritional doses . The same examinations were performed with 97 diabetic patients who completed the 5-year follow-up period . The best-corrected visual acuity , DR score , MDA , and TAS values were compared at the beginning and the end of the follow-up . Results Best-corrected visual acuity did not change during the follow-up , irrespective of supplementation . However , the retinopathy stage showed a retardation of progression in the subgroup with supplementation , but worsened in the subgroup with no antioxidant supplementation . Furthermore , the antioxidant supplementation group maintained its antioxidant plasma status levels , which was related to decreased oxidative plasma activity . Conclusions Oral antioxidant supplementation could be a useful adjunctive long-term therapy in the treatment of nonproliferative DR
Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .