Conclusions No conclusive recommendations were possible due to wide variation in study quality , method ologies and outcome measures .
A synthesis of available literature suggests that treatments containing urea as a primary active ingredient have been the most research ed .
Background Xerosis , literally dryness of the skin , of the foot is a common condition encountered clinical ly , which can lead to discomfort and predisposition to infection .
Currently , there are no evidence -based recommendations on which moisturiser formulations best alleviate xerotic symptoms .
The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis , by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population .
Fungal chitin-glucan scaffold for managing diabetic xerosis of the feet in menopausal women
Background : Corneocyte accumulation ( hyperkeratosis , xerosis ) commonly occurs in the stratum corneum ( SC ) of the feet of diabetic patients , as well as menopausal women . Objective : To compare the effects of a 1.5 % chitin-glucan formulation with its placebo , and commercially available glycerol formulations . Methods : This two-step controlled double-blind , r and omized , intra-individual study was performed in 30 type 1 and 2 diabetic menopausal women suffering from xerosis of the feet . The formulations were applied once daily for 3 weeks . Electrometric assessment s were performed on three sites of the feet at entry in the study , at weekly intervals during the treatment phase , and in a 2-week follow-up out of treatment . Positive controls consisted in two commercially available formulations enriched in glycerol . Results : Data revealed an unequivocal benefit provided by the 1.5 % chitin-glucan formulation compared with placebo . The electrometric values were significantly higher at each evaluation time during both treatment and follow-up phases . The two glycerol-enriched formulations showed slightly different kinetics of SC moisturization . A steep increase was followed by a plateau level and a rapid decline after stopping the treatments . Conclusion : The increased moisturization of the SC of the sole probably improves the desquamation process and reduces xerosis of the soles
Conclusions No conclusive recommendations were possible due to wide variation in study quality , method ologies and outcome measures .
A synthesis of available literature suggests that treatments containing urea as a primary active ingredient have been the most research ed .
Background Xerosis , literally dryness of the skin , of the foot is a common condition encountered clinical ly , which can lead to discomfort and predisposition to infection .
Currently , there are no evidence -based recommendations on which moisturiser formulations best alleviate xerotic symptoms .
The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis , by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population .