All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .
How to select elderly colorectal cancer patients for surgery: a pilot study in an Italian academic medical center
Objective Cancer is one of the most common diagnoses in elderly patients . Of all types of abdominal cancer , colorectal cancer ( CRC ) is undoubtedly the most frequent . Median age at diagnosis is approximately 70 years old worldwide . Due to the multiple comorbidities affecting elderly people , frailty evaluation is very important in order to avoid over- or under-treatment . This pilot study was design ed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for CRC . Methods Patients with 70 years old and older undergoing elective surgery for CRC were prospect ively enrolled in the study . The patients were preoperatively screened using 11 internationally-vali date d-frailty- assessment tests . The endpoints of the study were long-term mortality and living situation . The data were analyzed using univariate Cox proportional-hazard regression analysis to verify the predictive value of score indices in order to identify possible risk factors . Results Forty-six patients were studied . The median follow-up time after surgery was 4.6 years ( range , 2.9 - 5.7 years ) and no patients were lost to follow-up . The overall mortality rate was 39 % . Four of the patients who survived ( 4/28 , 14 % ) lost their functional autonomy . The preoperative impaired Timed Up and Go ( TUG ) , Eastern Cooperative Group Performance Status ( ECOG PS ) , Instrumental Activities of Daily Living ( IADLs ) , Vulnerable Elders Survey ( VES-13 ) scoring systems were significantly associated with increased long term mortality risk . Conclusion Simplified frailty-assessing tools should be routinely used in elderly cancer patients before treatment in order to stratify patient risk . The TUG , ECOG-PS , IADLs and VES-13 scoring systems are potentially able to predict long-term mortality and disability . Additional studies will be needed to confirm the preliminary data in order to improve management strategies for oncogeriatric surgical patients
All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .