Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention .
The data are insufficient to recommend the use of statins before EC .
Finally , perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF
The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation ( AF ) , inflammation and oxidative stress , with emphasis on the potential of statins to decrease the incidence of different types of AF , including new-onset AF , after electrical cardioversion ( EC ) and after cardiac surgery .
Observational and clinical trials have studied the impact of statin therapy on new-onset , post-EC or postoperative AF .
High sensitivity C-reactive protein: a novel predictor for recurrence of atrial fibrillation after successful cardioversion.
OBJECTIVES We sought to test the hypothesis that C-reactive protein ( CRP ) can predict the recurrence of atrial fibrillation ( AF ) after successful electrical cardioversion ( CV ) . BACKGROUND In patients with AF , CRP levels are predictive of immediate failure of CV . METHODS We prospect ively measured high-sensitivity CRP in 67 patients with AF or atrial flutter who underwent successful electrical CV .  RESULTS At one-month follow-up , 22 patients ( 33 % ) had recurrence of their arrhythmia . Arrhythmia recurrence was associated with significantly higher pre-CV  CRP levels ( odds ratio [ OR ] 1.84 ; 95 % confidence interval [ CI ] 1.14 to 2.98 ; p = 0.013 ) even after adjusting for age ( OR 2.22 ; 95 % CI 1.25 to 3.93 ; p = 0.006 ) , for gender ( OR 1.89 ; 95 % CI 1.16 to 3.09 ; p = 0.011 ) , or duration of arrhythmia ( OR 1.86 ; 95 % CI 1.13 to 3.07 ; p = 0.015 ) . On multivariate analysis , CRP was the only independent predictor of arrhythmia recurrence ( OR 2.19 ; 95 % CI 1.05 to 4.55 ; p = 0.036 ) . CONCLUSIONS Our data suggest that high levels of CRP are associated with an increased risk of recurrence of AF within one month . These data support the hypothesis that anti-inflammatory interventions may help in maintenance of normal sinus rhythm after CV . These data also may have implication s for the identification of patients who are most likely to experience substantial benefit from CV therapy for AF
Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention .
The data are insufficient to recommend the use of statins before EC .
Finally , perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF
The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation ( AF ) , inflammation and oxidative stress , with emphasis on the potential of statins to decrease the incidence of different types of AF , including new-onset AF , after electrical cardioversion ( EC ) and after cardiac surgery .
Observational and clinical trials have studied the impact of statin therapy on new-onset , post-EC or postoperative AF .