Synthesized evidence indicates that addition of multiple micronutrients to Fe supplementation may only marginally improve Hb response compared with Fe supplementation alone .
However , addition of ' other micronutrients ' may have a negative effect .
Routine addition of unselected multiple micronutrients to Fe therefore appears unjustified for nutritional anaemia control programmes
OBJECTIVES To study the effect of combining multiple ( two or more ) micronutrients with Fe supplementation on Hb response , when compared with placebo and with Fe supplementation , in children .
Calcium and phosphorus supplementation of iron-fortified infant formula: no effect on iron status of healthy full-term infants.
One objective of this clinical trial was to determine whether calcium and phosphorus supplementation of infant formula affects the iron status of healthy full-term infants . One hundred three infants were r and omly assigned to receive iron-fortified , cow milk-based infant formula ( 465 mg Ca and 317 mg P/L ) or the same formula with added calcium glycerophosphate ( 1800 mg Ca and 1390 mg P/L ) for 9 mo . Reported calcium intake for supplemented infants was about four times that of control infants , ranging from a mean of 1741 mg/d at baseline to 1563 mg/d at 9 mo . There was no difference by treatment group in mean or median change from baseline of serum ferritin , total-iron-binding capacity , erythrocyte protoporphyrin , or hematocrit at 4 and 9 mo after enrollment . Incidence of iron deficiency was similar for both groups and no infant developed iron deficiency anemia during the trial . This study indicates that the well-documented inhibitory effect of calcium and phosphorus on iron absorption is not clinical ly important in infants fed iron-fortified infant formula
Synthesized evidence indicates that addition of multiple micronutrients to Fe supplementation may only marginally improve Hb response compared with Fe supplementation alone .
However , addition of ' other micronutrients ' may have a negative effect .
Routine addition of unselected multiple micronutrients to Fe therefore appears unjustified for nutritional anaemia control programmes
OBJECTIVES To study the effect of combining multiple ( two or more ) micronutrients with Fe supplementation on Hb response , when compared with placebo and with Fe supplementation , in children .