The administration of probiotic/synbiotic were associated with a significant improvement in FPG , FBI , HOMA I-R , BMI .
It also modified Ferriman-Gallway , serum triglycerides , serum testosterone , hs-CRP , NO , TAC , GSH , and MDA .
Subgroup analysis of the type of intervention showed that probiotics were associated with greater testosterone and FPG reduction ;  synbiotics administration result ed in a more pronounced decrease of the FBI .
Subgroup analyses on the duration of therapy showed that , probiotic/synbiotic administration had a significantly greater effect on QUICK-I in the case of women with 12-weeks of therapy than in the 8-weeks therapy group .
Nevertheless , we did not observe any significant difference was observed in terms of FBI , HOMA-IR , and FPG .
Probiotics and synbiotics seem to either an effect on/influence metabolic , hormonal and inflammatory parameters , or can influence them .
Consequently , it could lead to an improvement of fertility in PCOS
Several r and omized controlled trials ( RCTs ) have investigated the use of probiotic/synbiotic in PCOS patients , without clarifying the real use in clinical practice .
The aim of this meta- analysis was to evaluate the effectiveness of probiotics and synbiotics on metabolic , hormonal and inflammatory parameters of PCOS  .
Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
Abstract The aim of the current study was to assess the effects of probiotic supplementation on weight loss , glycaemia and lipid profiles in women with polycystic ovary syndrome ( PCOS ) . In a r and omized , double-blind , placebo-controlled trial , 60 women with PCOS were r and omized to receive probiotic capsule ( n = 30 ) or placebo ( n = 30 ) for 12 weeks . Consumption of probiotic supplements result ed in a significant reduction in weight ( −0.5 ± 0.4 vs. + 0.1 ± 1.0 kg , p = 0.004 ) and BMI ( −0.2 ± 0.2 vs. + 0.03 ± 0.4 kg/m2 , p = 0.004 ) compared with the placebo . In addition , compared with the placebo , probiotic administration was associated with a significant decrease in fasting plasma glucose ( −2.4 ± 8.4 vs. + 2.1 ± 7.0 mg/dL , p = 0.02 ) , serum insulin concentrations ( −2.0 ± 5.8 vs. + 1.6 ± 5.0 μIU/mL , p = 0.01 ) , homoeostasis model of assessment -insulin resistance ( −0.5 ± 1.4 vs. + 0.3 ± 1.1 , p = 0.01 ) , homoeostatic model assessment -beta cell function ( −7.5 ± 22.3 vs. + 6.3 ± 21.7 , p = 0.01 ) , serum triglycerides ( −13.3 ± 51.3 vs. + 13.6 ± 37.1 mg/dL , p= 0.02 ) and a significant increase in quantitative insulin sensitivity check index ( QUICKI ) ( + 0.006 ± 0.01 vs. −0.005 ± 0.02 , p = 0.01 ) . When we adjusted the analysis for baseline values of biochemical parameters , age and baseline BMI , except for QUICKI ( p = 0.08 ) , other findings did not alter . We found that probiotic supplementation among PCOS women for 12 weeks had favourable effects on weight loss , markers of insulin resistance , triglycerides and VLDL-cholesterol concentrations
The administration of probiotic/synbiotic were associated with a significant improvement in FPG , FBI , HOMA I-R , BMI .
It also modified Ferriman-Gallway , serum triglycerides , serum testosterone , hs-CRP , NO , TAC , GSH , and MDA .
Subgroup analysis of the type of intervention showed that probiotics were associated with greater testosterone and FPG reduction ;  synbiotics administration result ed in a more pronounced decrease of the FBI .
Subgroup analyses on the duration of therapy showed that , probiotic/synbiotic administration had a significantly greater effect on QUICK-I in the case of women with 12-weeks of therapy than in the 8-weeks therapy group .
Nevertheless , we did not observe any significant difference was observed in terms of FBI , HOMA-IR , and FPG .
Probiotics and synbiotics seem to either an effect on/influence metabolic , hormonal and inflammatory parameters , or can influence them .
Consequently , it could lead to an improvement of fertility in PCOS
Several r and omized controlled trials ( RCTs ) have investigated the use of probiotic/synbiotic in PCOS patients , without clarifying the real use in clinical practice .
The aim of this meta- analysis was to evaluate the effectiveness of probiotics and synbiotics on metabolic , hormonal and inflammatory parameters of PCOS  .