Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Increased telomerase activity and vitamin D supplementation in overweight African Americans
Objective : We aim ed to investigate whether vitamin D supplementation modulates peripheral blood mononuclear cell ( P BMC ) telomerase activity in overweight African Americans . Design : A double blind , r and omized and placebo-controlled clinical trial ( # NCT01141192 ) was recently conducted . Subjects And Methods : African-American adults were r and omly assigned to either the placebo , or the vitamin D group ( 60 000 IU per month ( equivalent to ∼2000 IU per day ) oral vitamin D3 supplementation ) . Fresh P BMC s were collected from 37 subjects ( 18 in the placebo group and 19 in the vitamin D group ) , both at baseline and 16 weeks . P BMC telomerase activity was measured by the telomeric repeat amplification protocol . Results : Serum 25 hydroxyvitamin D levels increased from 40.7±15.7 at baseline to 48.1±17.5 nmol l–1 at posttest ( P=0.004 ) in the placebo group , and from 35.4±11.3 at baseline to 103.7±31.5 nmol l–1 at posttests ( P<0.0001 ) in the vitamin D group . In the vitamin D group , P BMC telomerase activity increased by 19.2 % from baseline ( 1.56±0.29 absorbance reading unit ( AU ) ) to posttest ( 1.86±0.42 AU , P<0.0001 ) . The significance persisted after controlling for age , sex and body mass index ( P=0.039 ) . P BMC telomerase activity in the placebo group did not change from baseline ( 1.43±0.26 AU ) to posttest ( 1.46±0.27 AU , P=0.157 ) . Conclusion : Vitamin D supplementation significantly increased P BMC telomerase activity in overweight African Americans . Our data suggest that vitamin D may improve telomere maintenance and prevent cell senescence and counteract obesity-induced acceleration of cellular aging
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .