Pain intensity of chronic non-cancer patients was reduced by cannabinoids consumption , but effect sizes were small .
Efficacy for neuropathic and non-neuropathic pain was similar
There is growing interest in using cannabinoids for chronic pain .
We performed a systematic review and meta- analysis of r and omized controlled trials to evaluate the analgesic efficacy and adverse effects of cannabinoids for chronic non-cancer pain .
Effect of Dronabinol on Central Neuropathic Pain After Spinal Cord Injury: A Pilot Study
Rintala DH , Fiess RN , Tan G , Holmes SA , Bruel BM : Effect of dronabinol on central neuropathic pain after spinal cord injury : A pilot study . Objective : To test the efficacy and safety of a cannabinoid , dronabinol , compared with an active control , diphenhydramine , in relieving neuropathic pain in persons with spinal cord injury . Design : A r and omized , controlled , double-blind , crossover pilot study . Results : Seven adults with spinal cord injury and neuropathic pain below the level of injury participated . Two participants withdrew while receiving dronabinol , their first medication . For the remaining five participants , change in pain on a scale of 0–10 from baseline to the end of the maintenance phase did not differ significantly between the two medications ( mean change , dronabinol : 0.20 ± 0.837 , range = −1.00 to 1.00 ; diphenhydramine : −1.80 ± 2.490 , range = −6.00 to 0 ; Wilcoxon Z = 1.63 , P = 0.102 ) . Similar results were found when the average of the two ratings during the maintenance phase was used ( dronabinol : −0.20 ± 0.671 , range = −0.50 to 1.00 ; diphenhydramine : −1.40 ± 1.245 , range = −3.50 to −0.50 ; Wilcoxon Z = 1.60 , P = 0.109 ) . The most common side effects were dry mouth , constipation , fatigue , and drowsiness for both medications . Conclusions : On average , dronabinol was no more effective than diphenhydramine for relieving chronic neuropathic pain below the level of injury
Pain intensity of chronic non-cancer patients was reduced by cannabinoids consumption , but effect sizes were small .
Efficacy for neuropathic and non-neuropathic pain was similar
There is growing interest in using cannabinoids for chronic pain .
We performed a systematic review and meta- analysis of r and omized controlled trials to evaluate the analgesic efficacy and adverse effects of cannabinoids for chronic non-cancer pain .