Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .
Use of Onion Extract, Heparin, Allantoin Gel in Prevention of Scarring in Chinese Patients Having Laser Removal of Tattoos: A Prospective Randomized Controlled Trial
BACKGROUND With rapid advancement in cutaneous laser therapy , Q-switched lasers have become the st and ard treatment for tattoo removal . The longer wavelength Q-switched Nd : YAG laser is used when removing tattoos in darker skin patients to avoid scarring and permanent pigment changes . Nevertheless , the local experience revealed that nearly 25 % of the Chinese patients developed scarring . Meanwhile , multiple clinical studies have shown that Contractubex gel ( Merz Pharma , Frankfurt , Germany ) was effective in the treatment and prevention of hypertrophic scars and keloids . OBJECTIVE To evaluate the efficacy of Contractubex gel in the prevention of scarring after laser removal of tattoos in Chinese patients . METHODS A total of 120 Chinese patients with 144 professional blue-black tattoos were recruited into the study . They were r and omly assigned into the Contractubex group or the control group . All patients were treated with a QS 1,064-nm Nd : YAG laser using a 3-mm spot size , a 10-Hz repeat rate , a pulse duration of 6 nanoseconds , and fluences that ranged from 3.6 to 4.8 J/cm2 ( mean fluence , 4.2 J/cm2 ) . The treated areas were assessed 3 months after the last treatments for clinical clearance and complications . RESULTS Fifty-two patients with 61 tattoos in the Contractubex group were able to achieve a mean clearing rate of 82.3±11.6 % . There were 7 tattoos in 7 patients that developed scarring , 4 patients had permanent hypopigmentation , and 3 patients had transient hyperpigmentation . In contrast , 55 patients with 68 tattoos in the control group had a mean clearing rate of 80.4±11.3 % . Among them , 16 tattoos in 14 patients developed scarring , 4 patients had permanent hypopigmentation , and 5 patients had transient hyperpigmentation . Although there was no significant difference in age , sex , fluence , treatment session , and clinical clearance between the two groups , the Contractubex group had a statistically significantly lower rate of scarring than the control group ( p<.05 ) . CONCLUSION Contractubex gel is effective in scar prevention in Chinese patients having laser removal of tattoos
Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .