Vitamin D has a potentially significant role for improving the symptoms of AD .
The results from this study suggest that vitamin D supplementation may help ameliorate the severity of AD , and can be considered as a safe and tolerable therapy .
OBJECTIVES Despite the evidence supporting the use of vitamin D supplements for managing atopic dermatitis ( AD ) , no meta- analysis providing definite conclusions in this field has been reported .
The purpose of the present study was to conduct a systematic review and meta- analysis of all controlled studies of vitamin D for treating AD to eluci date the efficacy of vitamin D for alleviating the symptoms of AD .
Evaluation of dietary intake of vitamin E in the treatment of atopic dermatitis: a study of the clinical course and evaluation of the immunoglobulin E serum levels.
BACKGROUND Vitamin E ( VE ) is a potent antioxidant that can improve the immune macrophage-mediated response , decrease the production and /or release of prostagl and ins in humans , and decrease the serum levels of immunoglobulin E ( IgE ) in atopic subjects . AIM To compare the effects of placebo ( PL ) and VE intake ( 400 IU/day ) on subjective symptoms and serum IgE levels in 96 subjects with atopic dermatitis . MATERIAL S AND METHODS A single-blind clinical analysis was performed on 96 subjects r and omly divided into two groups . Fifty subjects were given orally 400 IU ( 268 mg ) of VE of natural origin , once a day for 8 months , and 46 took PL for the same period . Complete blood count , serum IgE levels , radioallergosorbent test ( RAST ) score , antinuclear antibodies ( ANA ) , and biochemical analysis were obtained at the time of enrollment and every 15 days during the 8 months of the study . To evaluate VE therapy , a question naire was sent to each subject for completion at the end of the study . RESULTS The results were as follows : ( A ) four subjects treated with VE worsened , compared to 36 in the PL group ; ( B ) six subjects in the VE group and five in the PL group showed no change ; ( C ) slight improvement was observed in 10 subjects in the VE group and four in the PL group ; ( D ) 23 of the 50 subjects treated with VE showed great improvement , compared to only one in the PL group ; and ( E ) there was almost complete remission of atopic dermatitis in seven of the 50 subjects in the VE group , but none in the PL group . Females showed less progression of atopic dermatitis than males in both groups and a higher percentage of almost complete remission ( five females and two males ) . The range of serum IgE levels varied markedly from 1005 to 490 IU/mL in the VE group and from 1239 to 812 IU/mL in the PL group over 8 months . Subjects with great improvement and near remission of atopic dermatitis in the VE group demonstrated a decrease of 62 % in serum IgE levels based on initial conditions , while , in subjects taking PL , the difference was approximately 34.4 % . No complications were observed in either group . A remarkable improvement in facial erythema , lichenification , and the presence of apparently normal skin was reported . Eczematous lesions healed mostly as a result of decreased pruritus . CONCLUSIONS The correlation between VE intake , IgE levels , and the clinical manifestations of atopy indicates that VE could be an excellent therapeutic tool for atopic dermatitis
Vitamin D has a potentially significant role for improving the symptoms of AD .
The results from this study suggest that vitamin D supplementation may help ameliorate the severity of AD , and can be considered as a safe and tolerable therapy .
OBJECTIVES Despite the evidence supporting the use of vitamin D supplements for managing atopic dermatitis ( AD ) , no meta- analysis providing definite conclusions in this field has been reported .
The purpose of the present study was to conduct a systematic review and meta- analysis of all controlled studies of vitamin D for treating AD to eluci date the efficacy of vitamin D for alleviating the symptoms of AD .