Good disease control , with therapeutic escalation to achieve low disease activity , was recommended .
OBJECTIVE To develop treatment recommendations for children with juvenile idiopathic arthritis manifesting as non-systemic polyarthritis , sacroiliitis , or enthesitis .
Long-term outcome of patients with JIA treated with etanercept, results of the biologic register JuMBO.
OBJECTIVE To assess the outcome of adult patients with JIA who received etanercept ( ETA ) during childhood . METHODS JuMBO ( Juvenile arthritis MTX/Biologics long-term Observation ) is an ongoing prospect i ve cohort study . It follows adult JIA patients who were formerly included in the national JIA biologic register . In JuMBO , clinical status , therapy and the occurrence of adverse events are documented every 6 months by physicians ; additionally , patient-derived data are included [ e.g. functional capacity and health-related quality of life ( HRQoL ) ] . Here , data from the last available visit of patients were analysed . RESULTS Until December 2010 , 346 patients with a median age of 21 years were included in JuMBO . The majority of them had polyarthritis . Seventy-eight per cent of them were still on DMARDs , 45 % on ETA . The disease was inactive in about one in five patients . A restricted functional capacity was reported by 51 % of participants and fatigue by 76 % . The patients judged their HRQoL to be lower than a reference group from the general population , but only with regard to physical health . HRQoL correlated with the patient 's perceived fatigue . Most frequently observed comorbidities in the young adults with JIA were disease related and included uveitis , IBDs and psoriasis . During the observation period , 2.1 severe infections and 1.5 new-onset autoimmune events per 100 patient-years were reported in patients on ETA , respectively . CONCLUSION The first data from the JuMBO register indicate an improved long-term outcome of patients with severe JIA treated in the biologic era and an acceptable safety profile of ETA
Good disease control , with therapeutic escalation to achieve low disease activity , was recommended .
OBJECTIVE To develop treatment recommendations for children with juvenile idiopathic arthritis manifesting as non-systemic polyarthritis , sacroiliitis , or enthesitis .