The effect of testosterone supplementation on BMD and the risk of falls or fracture remains inconclusive .
However , supplementation may benefit patients in the areas of sexual function and quality of life without increasing the risk of cardiovascular events , all-cause mortality , or prostatic events .
Testosterone deficiency ( TD ) may induce a series of clinical symptoms .
Studies have shown that testosterone supplementation may prevent these unfavourable symptoms and improve patients ’ quality of life .
Given the conflicting findings across studies , this systematic review aims to evaluate the effects and risks associated with testosterone supplementation in middle-aged or aging males with TD .
Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone
This prospect i ve 2-year , single-center , r and omized , placebo-controlled , open-label clinical trial was performed to evaluate the efficacy of low-dose testosterone undecanoate ( TU ) treatment on bone mineral density ( BMD ) and biochemical markers of bone turnover in elderly male osteoporosis with low serum testosterone . A total of 186 elderly male osteoporosis patients with low serum testosterone were r and omized into three groups : low-dose TU ( 20 mg , per day ) , st and ard-dose TU ( 40 mg , per day ) , and placebo group with a 24-month followup . Since the 6th month in st and ard-dose TU group or since the 12th month followup in low-dose TU group and throughout the study , lumbar spine and femoral neck BMD and serum levels of free testosterone , estradiol , and bone alkaline phosphatase significantly increased . There were no significant differences between groups of low-dose TU and st and ard dose TU in the percentage of changes of these data since the 18th month followup and throughout the study . No side effects on prostate gl and s including prostate specific antigen were found . In conclusion , low-dose TU ( 20 mg , per day ) may be a cost effective and safe protocol for treating elderly male osteoporosis with low serum testosterone
The effect of testosterone supplementation on BMD and the risk of falls or fracture remains inconclusive .
However , supplementation may benefit patients in the areas of sexual function and quality of life without increasing the risk of cardiovascular events , all-cause mortality , or prostatic events .
Testosterone deficiency ( TD ) may induce a series of clinical symptoms .
Studies have shown that testosterone supplementation may prevent these unfavourable symptoms and improve patients ’ quality of life .
Given the conflicting findings across studies , this systematic review aims to evaluate the effects and risks associated with testosterone supplementation in middle-aged or aging males with TD .