On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis.
OBJECTIVE To examine the safety and tolerability of clonidine used alone or with methylpheni date in children with attention-deficit/hyperactivity disorder ( ADHD ) . METHOD In a 16-week multicenter , double-blind trial , 122 children with ADHD were r and omly assigned to clonidine ( n = 31 ) , methylpheni date ( n = 29 ) , clonidine and methylpheni date ( n = 32 ) , or placebo ( n = 30 ) . Doses were flexibly titrated up to 0.6 mg/day for clonidine and 60 mg/day for methylpheni date ( both with divided dosing ) . Groups were compared regarding adverse events and changes from baseline to week 16 in electrocardiograms and vital signs . RESULTS There were more incidents of bradycardia in subjects treated with clonidine compared with those not treated with clonidine ( 17.5 % versus 3.4 % ; p = .02 ) , but no other significant group differences regarding electrocardiogram and other cardiovascular outcomes . There were no suggestions of interactions between clonidine and methylpheni date regarding cardiovascular outcomes . Moderate or severe adverse events were more common in subjects on clonidine ( 79.4 % versus 49.2 % ; p = .0006 ) but not associated with higher rates of early study withdrawal . Drowsiness was common on clonidine , but generally resolved by 6 to 8 weeks . CONCLUSIONS Clonidine , used alone or with methylpheni date , appears safe and well tolerated in childhood ADHD . Physicians prescribing clonidine should monitor for bradycardia and advise patients about the high likelihood of initial drowsiness
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .