Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .
Serum lipid response to a fat-modified, oatmeal-enhanced diet.
The purpose of this study was to confirm and extend previous findings that serum cholesterol response to a fat-modified diet is enhanced by oat fiber .  Participants ( n = 236 ) were recruited from the Continental Illinois National Bank in Chicago . Data including weight , serum lipid level , lipoproteins , and 3-day food records were collected at baseline and every 4 weeks for 12 weeks . All participants were instructed to follow the fat-modified ( Phase II ) diet recommended by the American Heart Association ( AHA ) . After 4 weeks , participants were r and omly assigned to one of two groups . While both groups continued to follow the AHA diet , Group 1 was instructed to include 2 oz ( 56 g , dry wt ) of oatmeal , isocalorically substituted for other carbohydrate foods . Group 2 served as the control and consumed no oat products throughout the study .  Serum cholesterol values at baseline and after 4 weeks of the AHA diet were similar for both groups ( 203.9 and 193.0 mg/dl for Group 1 and 205.3 and 194.5 mg/dl for Group 2 ) . After 4 weeks of oatmeal intervention , mean group differences were -6.8 and -2.1 mg/dl ( P = 0.008 one-tailed t test ) for Groups 1 and 2 , respectively . Following an additional 4 weeks of oatmeal intervention , the Group 1 mean cholesterol increased slightly ( 0.9 mg/dl ) , while the Group 2 level decreased slightly ( -0.7 mg/dl ) . Overall serum cholesterol responses for the two groups from Visit 2 to Visit 4 were -6.0 and -2.8 mg/dl for Groups 1 and 2 , respectively ( P = 0.074 , one tail ) . Changes in weight were small and nonsignificant . Subgroup analyses revealed greater reductions in serum cholesterol among participants with the highest baseline serum cholesterol ( -8.0 mg/dl vs -1.7 mg/dl for Subgroups 1 and 2 , respectively ) . These data support previous findings that inclusion of oatmeal in a fat-modified diet is helpful in lowering serum cholesterol , particularly for individuals with elevated serum cholesterol levels
Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .