The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Low-dose captopril for the treatment of mild to moderate hypertension.
Short-term results of this double-blind control trial ( previously reported ) in patients with initial diastolic blood pressures ( DBP ) in the range of 92 - 109 mm Hg indicated that doses of 12.5 or 25 mg captopril ( C )  three times daily ( t.i.d . ) and 37.5 mg twice daily ( b.i.d . ) had similar antihypertensive effectiveness as 50 mg t.i.d . After 7 weeks of C , the addition of hydrochlorothiazide ( H ) to two-thirds of the patients enhanced the antihypertensive response . This report presents the results of unchanged and uninterrupted treatment for 9.5 months in 46 patients taking C alone , and for 7.8 months in 94 patients taking C plus H or H alone .  With C alone , reductions in DBP averaged 8.3 , 11.0 , 15.1 , and 17.5 mm Hg with the 12.5 , 25 , 37.5 , and 50 mg doses respectively . The response to the 12.5 mg dose only was significantly less than the 50 mg dose . With H alone , the reduction in DBP averaged 10.6 mm Hg and with C plus H reductions averaged 15.6 , 18.1 , 16.8 , and 18.7 mm Hg with the 12.5 , 25 , 37.5 , and 50 mg doses of C , respectively . Reductions in DBP with C plus H regimens were significantly different from H alone . There was no waning of effectiveness from short to long term except for the 12.5 mg dose of C alone . During the long-term phase , two patients developed rash and one lost the sense of taste . Neutropenia in one patient probably was not drug-related . There were no terminations for elevated DBP greater than 104 mm Hg on two successive visits . ( ABSTRACT TRUNCATED AT 250 WORDS
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .