: Probiotic supplementation reduces the risk of LOS in preterm infants
CONTEXT : Late-onset sepsis ( LOS ) is a major cause of mortality and morbidity in preterm infants .
Despite various preventive measures , its incidence continues to remain high , hence the urgent need for additional approaches .
One such potential strategy is supplementation with probiotics .
Currently there are > 30 r and omized controlled trials ( RCTs ) of probiotics in preterm infants that have reported on LOS .
[Effects of probiotics on feeding intolerance in low birth weight premature infants].
OBJECTIVE To study the efficacy and safety of probiotics for the prevention of feeding intolerance in low birth weight ( LBW ) premature infants . METHODS Sixty eligible LBW premature infants were r and omly divided into probiotics and conventional treatment groups ( n=30 each ) . Both groups received treatment of the primary disease . Additionally , the probiotics treatment group was administered with probiotics ( 0.25 g , twice daily ) . The incidence of feeding intolerance , the time to regain birth weight and to reach full enteral nutrition and the length of hospitalization were compared between the two groups . The occurrence of adverse reactions was recorded . RESULTS The incidence of feeding intolerance in the probiotics treatment group was lower than that in the conventional treatment group ( 4 % vs 14 % ; P<0.01 ) . The time to regain birth weight ( 6.8±1.2 days vs 7.7±1.6 days ; P<0.05 ) and the time to reach full enteral nutrition ( 8.0±1.4 days vs 9.0±2.0 days ; P<0.05 ) in the probiotics treatment group were shorter than those in the conventional treatment group . No adverse reactions were observed in the probiotics treatment group . CONCLUSIONS Probiotics can reduce the incidence of feeding intolerance in LBW premature infants , can promote weight gain and shorten the time to reach full enteral nutrition . The application of probiotics appears to be safe in LBW premature infants
: Probiotic supplementation reduces the risk of LOS in preterm infants
CONTEXT : Late-onset sepsis ( LOS ) is a major cause of mortality and morbidity in preterm infants .
Despite various preventive measures , its incidence continues to remain high , hence the urgent need for additional approaches .
One such potential strategy is supplementation with probiotics .
Currently there are > 30 r and omized controlled trials ( RCTs ) of probiotics in preterm infants that have reported on LOS .