Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome.
BACKGROUND It has been shown that there is an increase in oxidative stress in polycystic ovary syndrome ( PCOS ) .  Statins are considered to have a pleiotropic effect other than their lipid-lowering effect . These effects may be mediated in part by reducing oxidative stress . METHODS This r and omized , double-blind , placebo-controlled study was conducted to assess the effect of atorvastatin on serum malondialdehyde ( MDA ) concentrations as a marker of oxidative stress in patients with PCOS . Forty medication-naïve patients with PCOS were r and omized to either atorvastatin 20 mg daily or placebo for 3 months . A 3-month extension study for both groups of patients was undertaken with metformin 1500 mg daily after completing initial 3 months of atorvastatin or placebo . RESULTS There was a significant decrease of MDA concentrations  with atorvastatin [ mean ( sem ) ] [ 0.29 ( 0.04 ) vs. 0.25 ( 0.02 ) μmol/liter ; P < 0.01 ] compared with placebo [ 0.28 ( 0.02 ) vs. 0.29 ( 0.12 ) μmol/liter ; P = 0.52 ] . Three months treatment with metformin result ed in further reduction of MDA levels  with atorvastatin compared with baseline [ 0.25 ( 0.02 ) baseline vs. 0.23 ( 0.03 ) μmol/liter for atorvastatin treated ; P = 0.02 ] . There was also a significant correlation between the reduction in MDA with a reduction in high-sensitivity C-reactive protein ( r = 0.71 , P < 0.01 ) , an increase in 25-hydroxyvitamin D ( 25OHD ; r = -0.68 , P = 0.02 ) , and a reduction in testosterone levels ( r = 0.63 , P = 0.01 ) . Multiple linear regression analysis revealed Δ25OHD , ΔC-reactive protein , and Δtestosterone were independent predictors of changes in MDA after atorvastatin treatment . No correlation was observed between the reductions in serum MDA concentrations with changes in the lipid parameters . CONCLUSIONS Twelve weeks of atorvastatin led to a significant reduction in oxidative stress as determined by MDA concentrations among patients with polycystic ovary syndrome that was independently predicted by changes in testosterone , 25OHD , and high-sensitivity C-reactive protein
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .