Calcium was more effective than placebo in reducing rates of bone loss after two or more years of treatment .
REVIEW ER 'S CONCLUSIONS Calcium supplementation alone has a small positive effect on bone density .
The data show a trend toward reduction in vertebral fractures , but it is unclear if calcium reduces the incidence of non vertebral fractures
BACKGROUND Although calcium is one the simplest and least expensive strategies for preventing osteoporotic fractures calcium supplementation is nevertheless not without controversy ( Kanis 1989 ; Nordin 1990 ) .
The Food and Drug Administration in the US has permitted a bone health cl aim for calcium-rich foods , and the NIH in its Consensus Development Process approved a statement that high calcium intake reduces the risk of osteoporosis .
OBJECTIVES To assess the effects of calcium on bone density and fractures in postmenopausal women .
Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.
BACKGROUND Inadequate dietary intake of calcium and vitamin D may contribute to the high prevalence of osteoporosis among older persons . METHODS We studied the effects of three years of dietary supplementation with calcium and vitamin D on bone mineral density , biochemical measures of bone metabolism , and the incidence of nonvertebral fractures in 176 men and 213 women 65 years of age or older who were living at home . They received either 500 mg of calcium plus 700 IU of vitamin D3 ( cholecalciferol ) per day or placebo .  Bone mineral density was measured by dual-energy x-ray absorptiometry , blood and urine were analyzed every six months , and cases of nonvertebral fracture were ascertained by means of interviews and verified with use of hospital records . RESULTS The mean ( + /-SD ) changes in bone mineral density in the calcium-vitamin D and placebo groups were as follows : femoral neck , + 0.50+/-4.80 and -0.70+/-5.03 percent , respectively ( P=0.02 ) ; spine,+2.12+/-4.06 and + 1.22+/-4.25 percent ( P=0.04 ) ; and total body , + 0.06+/-1.83 and -1.09+/-1.71 percent ( P<0.001 ) . The difference between the calcium-vitamin D and placebo groups was significant at all skeletal sites after one year , but it was significant only for total-body bone mineral density in the second and third years . Of 37 subjects who had nonvertebral fractures , 26 were in the placebo group and 11 were in the calcium-vitamin D group ( P=0.02 ) . CONCLUSIONS In men and women 65 years of age or older who are living in the community , dietary supplementation with calcium and vitamin D moderately reduced bone loss measured in the femoral neck , spine , and total body over the three-year study period and reduced the incidence of nonvertebral fractures
Calcium was more effective than placebo in reducing rates of bone loss after two or more years of treatment .
REVIEW ER 'S CONCLUSIONS Calcium supplementation alone has a small positive effect on bone density .
The data show a trend toward reduction in vertebral fractures , but it is unclear if calcium reduces the incidence of non vertebral fractures
BACKGROUND Although calcium is one the simplest and least expensive strategies for preventing osteoporotic fractures calcium supplementation is nevertheless not without controversy ( Kanis 1989 ; Nordin 1990 ) .
The Food and Drug Administration in the US has permitted a bone health cl aim for calcium-rich foods , and the NIH in its Consensus Development Process approved a statement that high calcium intake reduces the risk of osteoporosis .
OBJECTIVES To assess the effects of calcium on bone density and fractures in postmenopausal women .