Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .
Conjugated linoleic acid induces lipid peroxidation in humans
Conjugated linoleic acid ( CLA ) is shown to have chemoprotective properties in various experimental cancer models . CLA is easily oxidised and it has been suggested that an increased lipid oxidation may contribute to the antitumorigenic effects . This report investigates the urinary levels of 8‐iso‐PGF2α , a major isoprostane and 15‐keto‐dihydro‐PGF2α , a major metabolite of PGF2α , as indicators of non‐enzymatic and enzymatic lipid peroxidation after dietary supplementation of CLA in healthy human subjects for 3 months . A significant increase of both 8‐iso‐PGF2α and 15‐keto‐dihydro‐PGF2α in urine was observed after 3 months of daily CLA intake ( 4.2 g/day ) as compared to the control group ( P<0.0001 ) . Conjugated linoleic acid had no effect on the serum α‐tocopherol levels . However , γ‐tocopherol levels in the serum increased significantly ( P=0.015 ) in the CLA‐treated group . Thus , CLA may induce both non‐enzymatic and enzymatic lipid peroxidation in vivo . Further studies of the mechanism behind , and the possible consequences of , the increased lipid peroxidation after CLA supplementation are urgently needed
Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .