R and omized controlled trials found a positive correlation for SB with BMI , neck circumference , fat mass , HbA1C , cholesterol and insulin levels , cohort studies additionally for WC , leptin , C-peptide , ApoA1 and Low density lipoprotein and a negative correlation for HDL .
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin .
OBJECTIVE Pathomechanisms of sedentary behaviour ( SB ) are unclear .
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults .
Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes
Background and aims We investigated whether objective ly measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes . Methods and results We studied 285 adults ( 184 men , 101 women , mean age 59.0 ± 9.7 ) who had been recruited to the Early ACTivity in Diabetes ( Early ACTID ) r and omised controlled trial .  C-reactive protein ( CRP ) , adiponectin , soluble intracellular adhesion molecule-1 ( sICAM-1 ) , interleukin-6 ( IL-6 ) , and accelerometer-determined sedentary time and moderate-vigorous physical activity ( MVPA ) were measured at baseline and after six-months . Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time  with markers of inflammation . At baseline , associations between sedentary time and IL-6 were observed in men and women , an association that was attenuated following adjustment for waist circumference . After 6 months of follow-up  , sedentary time was reduced by 0.4 ± 1.2 h per day in women , with the change in sedentary time predicting CRP at follow-up . Every hour decrease in sedentary time  between baseline and six-months was associated with 24 % ( 1 , 48 ) lower CRP . No changes in sedentary time between baseline and 6 months were seen in men . Conclusions  Higher sedentary time  is associated with IL-6 in men and women with type 2 diabetes , and reducing sedentary time is associated with improved levels of CRP in women . Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes
R and omized controlled trials found a positive correlation for SB with BMI , neck circumference , fat mass , HbA1C , cholesterol and insulin levels , cohort studies additionally for WC , leptin , C-peptide , ApoA1 and Low density lipoprotein and a negative correlation for HDL .
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin .
OBJECTIVE Pathomechanisms of sedentary behaviour ( SB ) are unclear .
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults .