The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .
Effects of olmesartan, an angiotensin II receptor blocker, and amlodipine, a calcium channel blocker, on Cardio-Ankle Vascular Index (CAVI) in type 2 diabetic patients with hypertension.
AIM Recently , a novel device for measuring the cardio-ankle vascular index ( CAVI ) as an arterial stiffness parameter has been developed . In this study , we evaluated the effect of angiotensin II receptor blocker ( ARB ) and calcium channel ( Ca ) blocker on CAVI in type 2 diabetic patients with hypertension . METHODS Seventy type 2 diabetes mellitus patients with hypertension were enrolled and r and omly divided into two groups . One group was administered olmesartan medoxomil 20 mg/day [ DOSAGE ERROR CORRECTED ] for 12 months ( ARB group ) , and the other group was administered amlodipine besilate 5 mg/day for 12 months ( Ca blocker group ) . RESULTS In the ARB group , a significant decrease in CAVI was observed after 12 months ; however , no significant change in CAVI was observed in the Ca blocker group although changes in blood pressure were almost the same . By simple regression analyses , CAVI changes correlated positively with 8-OHdG changes . CONCLUSIONS Olmesartan , an ARB , improved arterial stiffness more than amlodipine , and this effect might be due to not only the blood pressure-lowering effect but also to reducing the potential of oxidative stress recognized in olmesartan
The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .