The National Eye Institute Visual Function Question naire-25 , Impact of Vision Impairment and Treatment Satisfaction Survey-Intraocular Pressure had the highest number of positive ratings in the content validity assessment .
Conclusion This study provides a descriptive catalogue of vision-specific PRO instruments , to inform the choice of an appropriate measure of patient-reported outcomes in a glaucoma context
Purpose To identify  vision Patient-Reported Outcomes instruments relevant to glaucoma and assess their content validity .
Relating spontaneous adverse experience reports to scores on a questionnaire querying tolerability.
In this study , we examined the relation between spontaneously reported adverse experiences and responses given on the comparison of ophthalmic medications for tolerability ( COMTOL ) checklist question naire which queries the frequency and bother of specific side-effects known to be associated with topical ophthalmic agents used to treat ocular hypertension or open-angle glaucoma , and the impact that the side-effects have on health-related quality of life . The study was a 4-week , r and omized , open-label , two-period cross-over clinical trial comparing dorzolamide and pilocarpine in 92 patients who were also receiving timolol for the treatment of ocular hypertension or open-angle glaucoma . Patients completed the COMTOL question naire at baseline and at the end of each period and spontaneous reports of adverse experiences ( AEs ) were collected throughout the study by the investigator . Since there were only 3 spontaneously reported AEs related to drug treatment while patients received dorzolamide and since COMTOL scores indicated a low level of side-effects , the analyses were limited to pilocarpine treatment periods . We discovered that during the pilocarpine treatment periods , a large percentage ( 94 % ) of the 47 patients , who failed to spontaneously report any adverse experiences , indicated on the COMTOL that they had experienced side-effects . These discrepancies between the methods of spontaneous reports and a checklist question naire are similar to those previously reported in the literature for other drugs . Unlike previous literature , we went beyond identifying discrepancies with the two reporting methods and we looked for possible explanations for why the discrepancies existed . We discovered that patients who spontaneously reported AEs expressed more bother from these specific side-effects on the question naire than patients who did not spontaneously report AEs . As well , patients who spontaneously reported AEs and discontinued drug as a result of the AEs expressed on the COMTOL the greatest bother from side-effects . This trend of increasing negative impact ( as patients reported AEs and discontinued ) was also observed with COMTOL global question scores on the impact of side-effects on health-related quality of life , the impact of activity limitations on quality of life , satisfaction with medication and compliance with medication . Therefore , spontaneous reporting of side-effects appears to be detecting the most clinical ly meaningful side-effects
The National Eye Institute Visual Function Question naire-25 , Impact of Vision Impairment and Treatment Satisfaction Survey-Intraocular Pressure had the highest number of positive ratings in the content validity assessment .
Conclusion This study provides a descriptive catalogue of vision-specific PRO instruments , to inform the choice of an appropriate measure of patient-reported outcomes in a glaucoma context
Purpose To identify  vision Patient-Reported Outcomes instruments relevant to glaucoma and assess their content validity .