The associations between BP-lowering treatments and outcomes were not significantly different , irrespective of drug class , except for stroke and heart failure .
AND RELEVANCE Among patients with type 2 diabetes , BP lowering was associated with improved mortality and other clinical outcomes with lower RRs observed among those with baseline BP of 140 mm Hg and greater .
These findings support the use of medications for BP lowering in these patients
IMPORTANCE Lowering blood pressure ( BP ) is widely used to reduce vascular risk in individuals with diabetes .
OBJECTIVE To determine the associations between BP-lowering treatment and vascular disease in type 2 diabetes .
Timolol Treatment After Myocardial Infarction in Diabetic Patients
In diabetic patients long-term treatment with timolol after myocardial infa rct ion was related to a reduction in overall mortality , total cardiac death , sudden death , and nonfatal reinfa rct ion , compared with patients in a placebo group . The analyses were based on 99 diabetic patients in the Norwegian timolol multicenter study . The dosage of timolol was 10 mg twice daily and the follow-up period was 12–33 mo ( mean : 17 mo ) . When analyzing all r and omized patients , there were 14 deaths in the placebo group and 6 deaths in the timolol group , a reduction of 62.8 % ( P < 0.05 ) . The number of nonfatal reinfa rct ions was 10 in the placebo group and 2 in the timolol group , a reduction of 82.7 % ( P < 0.05 ) . With regard to inclusion rate , side effects , withdrawals , and timolol-related reduction in mortality and reinfa rct ion , the diabetic patients basically behaved like nondiabetic patients . The data were analyzed retrospectively and should be confirmed by a prospect i ve study . The study also indicates that long-term treatment with timolol may induce slight carbohydrate intolerance
The associations between BP-lowering treatments and outcomes were not significantly different , irrespective of drug class , except for stroke and heart failure .
AND RELEVANCE Among patients with type 2 diabetes , BP lowering was associated with improved mortality and other clinical outcomes with lower RRs observed among those with baseline BP of 140 mm Hg and greater .
These findings support the use of medications for BP lowering in these patients
IMPORTANCE Lowering blood pressure ( BP ) is widely used to reduce vascular risk in individuals with diabetes .
OBJECTIVE To determine the associations between BP-lowering treatment and vascular disease in type 2 diabetes .