The National Eye Institute Visual Function Question naire-25 , Impact of Vision Impairment and Treatment Satisfaction Survey-Intraocular Pressure had the highest number of positive ratings in the content validity assessment .
Conclusion This study provides a descriptive catalogue of vision-specific PRO instruments , to inform the choice of an appropriate measure of patient-reported outcomes in a glaucoma context
Purpose To identify  vision Patient-Reported Outcomes instruments relevant to glaucoma and assess their content validity .
Efficacy of brimonidine as replacement therapy in patients with open-angle glaucoma or ocular hypertension.
BACKGROUND Patients with glaucoma or ocular hypertension may have inadequately controlled  intraocular pressure ( IOP ) or experience adverse effects with their current medication regimens . OBJECTIVE This post hoc re analysis determined the effectiveness and tolerability of brimonidine used as replacement therapy in a real-life clinical practice setting . METHODS In this multicenter , open-label , observational , 2-month study , 460 patients received brimonidine  0.2 % as a 1:1 replacement for another antiglaucoma medication in their current regimen . Effectiveness was assessed by calculating the mean additional reduction in IOP from the treated baseline measurement ( before the switch to brimonidine ) to 2 months postbaseline , and by determining physicians ' opinions of treatment effectiveness . Tolerability was determined based on quality -of-life assessment s and recorded adverse events . RESULTS Overall , brimonidine replacement significantly reduced mean ( + /- SEM ) IOP by an additional 2.33 + /- 0.17 mm Hg ( 9.8 % + /- 0.9 % ; P < 0.001 ) . Significant additional reductions in IOP were seen when brimonidine replaced an agent used either as monotherapy or adjunctive therapy , regardless of the drug class of the agent replaced . However , particularly good hypotensive effectiveness and additional lowering of IOP were observed when brimonidine replaced certain medications , including latanoprost ( 12.44 % ; P < 0.003 ) and betaxolol ( 13.56 % ; P < 0.001 ) monotherapy , and latanoprost ( 16.08 % ; P < 0.010 ) adjunctive therapy . The effectiveness of brimonidine was rated as good or excellent by 92.4 % of physicians . All quality -of-life variables remained favorable or improved throughout the study , and brimonidine treatment was well tolerated . CONCLUSIONS Brimonidine 0.2 % used as a 1:1 replacement for monotherapy or adjunctive therapy with other antiglaucoma drugs significantly lowered IOP from that produced by previous therapy and was well tolerated .  Brimonidine offers a useful treatment option in patients who require replacement therapy
The National Eye Institute Visual Function Question naire-25 , Impact of Vision Impairment and Treatment Satisfaction Survey-Intraocular Pressure had the highest number of positive ratings in the content validity assessment .
Conclusion This study provides a descriptive catalogue of vision-specific PRO instruments , to inform the choice of an appropriate measure of patient-reported outcomes in a glaucoma context
Purpose To identify  vision Patient-Reported Outcomes instruments relevant to glaucoma and assess their content validity .