Data showed improvements secondary to exercise in ' physical function ' and ' general health ' .
The other domains - ' role physical ' , ' bodily pain ' , ' vitality ' , ' social ' , ' role emotional ' , and ' mental health ' - did not show improvement at six months .
Although results showed significant heterogeneity between trials , population s and outcomes were comparable overall , with findings relevant to the claudicant population .
High- quality evidence shows that exercise programmes provided important benefit compared with placebo or usual care in improving both pain-free and maximum walking distance in people with leg pain from IC who were considered to be fit for exercise intervention .
Exercise did not improve ABI , and we found no evidence of an effect of exercise on amputation or mortality .
Exercise may improve quality of life when compared with placebo or usual care .
BACKGROUND Exercise programmes are a relatively inexpensive , low-risk option compared with other , more invasive therapies for treatment of leg pain on walking ( intermittent claudication ( IC ) ) .
This is the fourth up date of a review first published in 1998 .
OBJECTIVES Our goal was to determine whether an exercise programme was effective in alleviating symptoms and increasing walking treadmill distances and walking times in people with intermittent claudication .
Secondary objectives were to determine whether exercise was effective in preventing deterioration of underlying disease , reducing cardiovascular events , and improving quality of life .
Efficacy and safety of oral porcine relaxin (pRLX) in adjunct to physical exercise in the treatment of peripheral arterial disease (PAD).
INTRODUCTION PAD medical therapy has a number of limitations . RLX showed promises in experimental model mainly through NO release . Our study is the first to evaluate the efficacy and safety of RLX in PAD . MATERIAL S- METHODS Eligible PAD La fontaine IIa-IIb patients were r and omized in 2 groups . Group A was treated with physical therapy plus oral pRLX , 20 ug b.i.d for 12 weeks , group B received physical therapy alone .  Pain Free Walking Distance ( PFWD ) and Maximum Walking Distance ( MWD ) at 3 and 12 wks and at follow up 3 months after treatment interruption were performed . RESULTS The percentage increases of PFWD in group B were 23 + /- 9 , 65 + /- 17 , and 35 + /- 4 respectively at 3 and at 12 weeks , and 3 months after termination . In Group A showed significantly higher percentage increases : 74 + /- 16 p < 0.01 , 168 + /- 28 p < 0.001 , and 122 + /- 15 p < 0.001 at the corresponding time points . The percentage increases of MWD in the B group were 29 + /- 7 , 55 + /- 10 and 54 + /- 8 at the above time points , while in the A group were 55 + /- 10 p < 0.001 , and 99 + /- 12 p < 0.001 . The RLX patients referred a better physical and mental status . No adverse events during or after the treatment were recorded . COMMENT RLX result ed very effective in PAD . Our results may suggest that the observed functional benefits should come not only from hemodynamic improvement but also from positive vascular remodeling
Data showed improvements secondary to exercise in ' physical function ' and ' general health ' .
The other domains - ' role physical ' , ' bodily pain ' , ' vitality ' , ' social ' , ' role emotional ' , and ' mental health ' - did not show improvement at six months .
Although results showed significant heterogeneity between trials , population s and outcomes were comparable overall , with findings relevant to the claudicant population .
High- quality evidence shows that exercise programmes provided important benefit compared with placebo or usual care in improving both pain-free and maximum walking distance in people with leg pain from IC who were considered to be fit for exercise intervention .
Exercise did not improve ABI , and we found no evidence of an effect of exercise on amputation or mortality .
Exercise may improve quality of life when compared with placebo or usual care .
BACKGROUND Exercise programmes are a relatively inexpensive , low-risk option compared with other , more invasive therapies for treatment of leg pain on walking ( intermittent claudication ( IC ) ) .
This is the fourth up date of a review first published in 1998 .
OBJECTIVES Our goal was to determine whether an exercise programme was effective in alleviating symptoms and increasing walking treadmill distances and walking times in people with intermittent claudication .
Secondary objectives were to determine whether exercise was effective in preventing deterioration of underlying disease , reducing cardiovascular events , and improving quality of life .