Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Association of circulating visfatin concentrations with insulin resistance and low-grade inflammation after dietary energy restriction in Spanish obese non-diabetic women: role of body composition changes.
BACKGROUND AND AIMS To assess the influence of body composition changes on circulating serum visfatin after following 12 weeks of energy restricted diet intervention . We also examined the possible role of visfatin in glucose metabolism and in obesity-associated low- grade inflammation . METHODS AND RESULTS A total of 78 obese ( BMI 34.0 ± 2.8 kg/m² ) women aged 36.7±7 y volunteered to participate in the study . We measured by DXA body fat mass ( FM ) and lean mass ( LM ) . Fasting serum visfatin , glucose , insulin , adiponectin , leptin , IL-1β , IL-6 , IL-8 , TNF-α and CRP concentrations were analyzed before and after the intervention and HOMA and QUIKI indexes were calculated . Mean weight loss 7.7 ± 3.0 kg and HOMA decreased in 24 ± 35 % . Serum visfatin concentration change was negatively associated with LM difference ( P < 0.05 ) , whereas no significant relationship was observed with FM changes after energy restricted diet intervention . Changes in circulating serum visfatin levels were significantly and inversely associated with HOMA-IR ( P < 0.01 ) and positively with QUICKI index ( P < 0.02 ) after energy restricted diet intervention , regardless of achieved body weight loss . We did not find any significant association between changes in visfatin levels and IL-1β , IL-6 , IL-8 , TNF-α and CRP levels after dietary intervention ( all P > 0.2 ) . CONCLUSION Circulating visfatin concentration is associated with sensitivity improvement achieved after energy restricted diet intervention induced weight loss . Furthermore , LM changes could be an influencing factor on visfatin concentrations and consequently , on the improvement of insulin sensitivity after weight loss in obese non-diabetic women . Our findings did not provide any evidence for a role of visfatin increase on low- grade inflammation after weight loss
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .