Sensitivity analyses and meta-regression for hemoglobin suggested a higher response with lower trial quality ( suboptimal allocation concealment and blinding ) , use of condiments , and sodium iron edetate and a lower response when adults were included .
Consumption of iron-fortified foods results in an improvement in hemoglobin , serum ferritin , and iron nutriture and a reduced risk of remaining anemic and iron deficient
BACKGROUND The utility of iron fortification of food to improve iron deficiency , anemia , and biological outcomes is not proven unequivocally .
Iron, zinc, copper and selenium status of breast‐fed infants and infants fed trace element fortified milk‐based infant formula
Infants were fed  cow 's milk‐based formulas  containing 4 mg of iron/I  from 1.5 to 6 months of age and their hematological status was compared to infants receiving the same formula but with 7 mg of iron/l and with breast‐fed infants . One formula with 4 mg of iron/l contained iron as ferrous sulfate , in another , part of the iron was provided as bovine lactoferrin . We also studied the effect of selenium ( 10 μg/l ) and copper ( 0.4 mg/l ) supplementation on selenium and copper status . There were no significant differences in hematological indices among the groups at 6 months of age ; all infants had satisfactory iron status . Serum transferrin receptor levels , a potential novel indicator of iron status , were highest in breast‐fed infants , suggesting a cellular need for iron , and lowest in infants receiving formula with 7 mg of iron/l . Selenium status , as assessed by serum glutathione peroxidase activity , was similar at 6 months of age in breast‐fed infants and infants fed  formula fortified with selenium but lower in infants fed unfortified formula . The lowest levels of glutathione peroxidase activity were found in infants fed the highest concentration of iron ( 7 mg/l ) . Serum copper concentrations were similar in all groups , but the lowest levels were found in infants fed the highest concentration of iron . These results suggest that 4 mg of iron/l is adequate for infants up to 6 months of age and that higher levels may have some negative effects
Sensitivity analyses and meta-regression for hemoglobin suggested a higher response with lower trial quality ( suboptimal allocation concealment and blinding ) , use of condiments , and sodium iron edetate and a lower response when adults were included .
Consumption of iron-fortified foods results in an improvement in hemoglobin , serum ferritin , and iron nutriture and a reduced risk of remaining anemic and iron deficient
BACKGROUND The utility of iron fortification of food to improve iron deficiency , anemia , and biological outcomes is not proven unequivocally .