A significant effect on depressive symptoms was not found .
The improvements for pain could be maintained at follow-up with smaller effects .
Introduction In the present systematic review and meta- analysis , we assessed the effectiveness of different forms of balneotherapy ( BT ) and hydrotherapy ( HT ) in the management of fibromyalgia syndrome ( FMS ) .
A double-blind comparison of ibuprofen, placebo and ibuprofen with meptazinol in soft tissue rheumatism.
The administration of ibuprofen potentiates and prolongs the analgesic effect of  meptazinol  when the two drugs are given simultaneously to mice . A double-blind three-way crossover study of placebo , ibuprofen ( 1600 mg/day ) and ibuprofen ( 1600 mg/day ) plus meptazinol ( 400 mg/day ) was carried out in 45 patients with soft tissue rheumatism to see if the same potentiation could be demonstrated in man . Treatment order was r and omized and each regimen was given for 2 weeks preceded by 1 week on paracetamol alone . Assessment s were made , on entry and after each treatment period , of pain parameters using visual analogue or verbal rating scales . Patients ' overall impression and final preference showed both active treatments to be better than placebo and demonstrated a slight preference for the combination
A significant effect on depressive symptoms was not found .
The improvements for pain could be maintained at follow-up with smaller effects .
Introduction In the present systematic review and meta- analysis , we assessed the effectiveness of different forms of balneotherapy ( BT ) and hydrotherapy ( HT ) in the management of fibromyalgia syndrome ( FMS ) .