In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics.
Steviol glycosides , isolated from the plant Stevia rebaudiana ( Bertoni ) Bertoni , have been used as safe sweetening agents for more than 30 years . Beneficial effects of high doses of steviol glycosides on hyperglycemia and hypertension have been previously described when these abnormalities are present . This study was design ed to evaluate the effects of steviol glycosides on blood glucose and on blood pressure ( BP ) in 3 groups of individuals . This was a r and omized , double-blind , placebo-controlled , long-term study in three groups of patients : Group 1 : subjects with Type 1 diabetes ; Group 2 : subjects with Type 2 diabetes ; and Group 3 : subjects without diabetes and with normal/low-normal BP levels . The subjects in each group were r and omly allocated to active treatment ( the steviol glycoside stevioside : 250 mg t.d.s . ) or to placebo treatment and followed-up for 3 months . Post-treatment systolic BP , diastolic BP , glucose and glycated hemoglobin ( HbA1c ) were not significantly different from baseline measurements , except for the placebo Type 1 diabetics group where a significant difference was observed for systolic BP and glucose . No side effects were observed in the two treatment groups . This study shows that oral steviol glycosides , taken as sweetener are well tolerated and have no pharmacological effect
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .