This meta- analysis concludes that hypovitaminosis D is associated with increased risk of hyperglycemia both in diabetic and non-diabetic subjects .
There is evidence that vitamin D status is associated with type 2 diabetes .
Many observational studies have been performed investigating the relationship of vitamin D status and circulating biomarkers of glycemic regulation .
To find out whether this association holds , we conducted a systematic review and meta- analysis of cross sectional and longitudinal studies .
Associations between Vitamin D Status and Type 2 Diabetes Measures among Inuit in Greenland May Be Affected by Other Factors
Objective Epidemiological studies have provided evidence of an association between vitamin D insufficiency and  type 2 diabetes .  Vitamin D levels have decreased among Inuit in Greenl and , and type 2 diabetes is increasing . We hypothesized that the decline in vitamin D could have contributed to the increase in type 2 diabetes , and therefore investigated associations between serum 25(OH)D3 as a measure of vitamin D status and glucose homeostasis and glucose intolerance in an adult Inuit population . Methods 2877 Inuit ( ≥18 years ) r and omly selected for participation in the Inuit Health in Transition study were included .  Fasting- and 2hour plasma glucose and insulin , C-peptide and HbA1c  were measured , and associations with serum 25(OH)D3 were analysed using linear and logistic regression . A sub sample of 330 individuals who also donated a blood sample in 1987 , were furthermore included . Results After adjustment , increasing serum 25(OH)D3 ( per 10 nmol/L ) was associated with higher fasting plasma glucose ( 0.02 mmol/L , p = 0.004 ) , 2hour plasma glucose ( 0.05 nmol/L , p = 0.002 ) and HbA1c ( 0.39 % , p<0.001 ) , and with lower beta-cell function ( -1.00 mmol/L , p<0.001 ) . Serum 25(OH)D3 was positively associated with impaired fasting glycaemia ( OR : 1.08 , p = 0.001 ) , but not with IGT or type 2 diabetes . Conclusions Our results did not support an association between low vitamin D levels and risk of type 2 diabetes . Instead , we found weak positive associations  between vitamin D levels and fasting- and 2hour plasma glucose levels , HbA1c and impaired fasting glycaemia , and a negative association with beta-cell function , underlining the need for determination of the causal relationship
This meta- analysis concludes that hypovitaminosis D is associated with increased risk of hyperglycemia both in diabetic and non-diabetic subjects .
There is evidence that vitamin D status is associated with type 2 diabetes .
Many observational studies have been performed investigating the relationship of vitamin D status and circulating biomarkers of glycemic regulation .
To find out whether this association holds , we conducted a systematic review and meta- analysis of cross sectional and longitudinal studies .