The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Effective dose range of enalapril in mild to moderate essential hypertension.
The dose-response relationship of enalapril was evaluated in a double-blind , balanced , two-period , incomplete-block study in 91 patients with mild to moderate essential hypertension . Patients were r and omly assigned to two of six treatments : placebo , 2.5 , 5 , 10 , 20 and 40 mg/day of enalapril maleate . There were two 3-week treatment periods , each preceded by a 4-week , single-blind placebo washout . Each dose of enalapril produced significant decreases in st and ing and supine systolic and diastolic blood pressure after 2 and 3 weeks of treatment . There were no significant changes on placebo . There was a significant linear dose response relationship for both mean blood pressure and mean change from baseline in blood pressure ( P less than 0.01 for systolic and mean arterial pressure , and P less than 0.05 for diastolic pressure ) . Enalapril was associated with an increasing dose-response relationship across the 2.5 - 40 mg/day range . The 2.5 mg/dose is effective in some patients ; however , doses greater than or equal to 10 mg/day may be necessary to achieve satisfactory blood pressure control
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .