Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Effect of caffeine on aortic elastic properties and wave reflection
Objective Caffeine is the most widely used pharmacologically active substance . Aortic elastic properties and arterial wave reflection are important factors for the efficient performance of the cardiovascular system , as well as prognosticators of cardiovascular risk . We investigated the effect of caffeine on aortic elastic properties and wave reflection . Design We studied the effect of caffeine  ( 250 mg ) in 20 healthy subjects according to a r and omized , placebo-controlled , double-blind , cross-over design . Methods Aortic stiffness was evaluated with  carotid-femoral pulse wave velocity and wave reflection with augmentation index of the aortic pressure waveform . Results Pulse wave velocity increased ( by 0.51 m/s , P < 0.001 ) denoting an increase in aortic stiffness . Augmentation index and augmented pressure increased ( by 6.8 % , and by 4.4 mmHg , respectively , P < 0.001 for both ) denoting increased wave reflections . Concurrently , both radial and aortic systolic , diastolic and pulse pressure increased significantly . However , this increase was 20 and 9 % larger for aortic systolic pressure ( at 30 and 60 min , P < 0.001 and P < 0.05 , respectively ) and 56 % larger for aortic pulse pressure ( at 30 min , P < 0.001 ) compared with the corresponding upper limb values . This indicates that peripheral pressure measurements are not an accurate guide for the pressor effect of caffeine in central arteries . Conclusions Caffeine affects unfavorably aortic stiffness and enhances wave reflections . This finding has implication s for the impact of caffeine consumption on cardiovascular risk
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .