On the contrary , the largest study of this review did not demonstrate any adverse effect of  DM on MWD and FWD after SET .
In conclusion , the data evaluating the effects of DM on SET were inadequate to determine if DM impairs the exercise response .
Some believe that certain patients with intermittent claudication may be unsuitable for supervised exercise therapy ( SET ) , based on the presence of comorbidities and the possibly increased risks .
We conducted a systematic review ( MEDLINE , EMBASE and CENTRAL ) to summarize evidence on the potential influence of diabetes mellitus ( DM ) on the response to SET .
Longitudinal predictors of reduced mobility and physical disability in patients with type 2 diabetes: the Fremantle Diabetes Study.
OBJECTIVE The purpose of this study was to determine longitudinal predictors of impaired mobility and physical disability in patients with type 2 diabetes . RESEARCH DESIGN AND METHODS We studied patients with type 2 diabetes who participated in a prospect i ve , community-based study .  A wide range of baseline variables were examined to determine whether they predicted future difficulties with 1 ) mobility and 2 )  basic activities of daily living ( ADLs ) in patients free of ADLs difficulty at baseline . To study mobility impairment , subjects with baseline mobility problems were also excluded . RESULTS After an average 4.6 + /- 2.3 and 4.8 + /- 2.3 years of follow-up in 818 and 934 patients , respectively , 28.5 % of subjects had developed new mobility impairment and 18.1 % had developed new ADL disability . In Cox proportional hazards models , the risk of mobility impairment was significantly increased by older age ( 6%/year ) , peripheral neuropathy ( 40 % increase ) , stroke history ( 123 % ) , insulin treatment ( 117 % ) , albuminuria , and arthritis ( 82 % ) ; taking exercise and being married lowered the risk ( by 39 and 32 % , respectively ) . The risk of new ADL disability was increased by baseline mobility problems ( 222 % increase ) , stroke ( 92 % ) , claudication ( 67 % ) , and depression ( 41 % ) and was also influenced by age , smoking , lack of exercise , non-fluency in English , and indigenous Australian ethnicity . CONCLUSIONS Both mobility impairment and ADL disability in type 2 diabetes have multiple causes that are due to diabetes complications and common comorbidities . The specific causes of each functional problem are largely distinct , and different approaches may be required to prevent their onset or progression
On the contrary , the largest study of this review did not demonstrate any adverse effect of  DM on MWD and FWD after SET .
In conclusion , the data evaluating the effects of DM on SET were inadequate to determine if DM impairs the exercise response .
Some believe that certain patients with intermittent claudication may be unsuitable for supervised exercise therapy ( SET ) , based on the presence of comorbidities and the possibly increased risks .
We conducted a systematic review ( MEDLINE , EMBASE and CENTRAL ) to summarize evidence on the potential influence of diabetes mellitus ( DM ) on the response to SET .