On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Pemoline, methylphenidate, and placebo in children with minimal brain dysfunction.
An eight-week double-blind comparison between pemoline ( Cylert ) , methylpheni date ( Ritalin ) hydrochloride , and placebo was carried out on 60 hyperactive children . Measurements of home , school , achievement , cognitive function , and global clinical status were made at baseline , midtreatment , end of treatment , and posttreatment . Both drugs produced improvement in all areas except the achievement measures . One major difference between drugs was the apparently longer action of pemoline , since its effects at home and school tended to persist when the drug was withdrawn , whereas the patients receiving methylpheni date tended to regress to their baseline levels
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .