A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?
Do patients who are treated with stem cell transplantation have a health-related quality of life comparable to the general population after 1 year?
Health-related quality of life ( HRQOL ) in leukemia and lymphoma patients treated with high-dose chemotherapy followed by allogeneic ( SCT ) and autologous ( ASCT ) stem cell transplantation or receiving combination chemotherapy ( CT )  was prospect ively assessed by the EORTC QLQ-C30 and compared with reference data from a general population sample . One year after transplant , the SCT group had functional scores which were close to population values except for lower social ( P < 0.0001 ) and role function ( P = 0.0004 ) . More symptoms and problems were reported , especially appetite loss ( P = 0.001 ) and financial difficulties ( P = 0.0001 ) . The ASCT patients reported a less than optimal HRQOL relative to the population 1 year post transplant . Cognitive , physical , role , and social function , dyspnoea , financial difficulties and global quality of life were most impaired ( P < 0.001 ) . in the ct group , physical , role and social function , dyspnoea and financial difficulties were impaired 1 year after start of chemotherapy , compared with the general population ( P < 0.001 ) . the eortc qlq-c30 was supplemented by a high-dose chemotherapy module , the hdc-19 , at the 1-year assessment , but no consistent differences were found across groups . fifteen to 34 % of the patients expressed fears of relapse and worries about future health , while 24–30 % indicated no participation in sexual activities
A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?