Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Simvastatin Preserves Coronary Endothelial Function in Hypercholesterolemia in the Absence of Lipid Lowering
Abstract —Recent evidence suggests that some benefit from the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors may occur independent of lipid lowering . We aim ed to determine the effect of simvastatin on coronary endothelial function , endothelial NO synthase ( eNOS ) expression , and oxidative stress in experimental hypercholesterolemia ( HC ) in the absence of cholesterol lowering . Pigs were r and omized to 3 experimental groups : normal diet ( N group ) , high cholesterol diet ( HC group ) , and HC diet with simvastatin ( HC+S group ) for 12 weeks . Low density lipoprotein cholesterol was similarly increased in the HC and HC+S groups compared with the N group . In vitro analysis of coronary large- and small-vessel endothelium-dependent vasorelaxation was performed . The mean vasorelaxation of epicardial vessels to bradykinin was significantly attenuated in the HC group compared with the N group ( 32.3±1.2 % versus 42.9±1.6 % , respectively;P < 0.0001 ) . This attenuation was significantly reversed in the HC+S group ( 38.7±1.5 % , P < 0.005 versus HC group ) . The maximal vasorelaxation to substance P was significantly attenuated in the HC group compared with the N group ( 50.5±11.9 % versus 79.3±5.3 % , respectively;P < 0.05 ) . This attenuated response was normalized in the HC+S group ( 74.9±4.1 % , P < 0.05 versus HC group ) . The maximal arteriolar vasorelaxation to bradykinin was also significantly attenuated in the HC group compared with the N group ( 71.9±4.9 % versus 96.8±1.34 % , respectively;P < 0.005 ) . This was reversed in the HC+S group ( 98.4±0.6 % , P < 0.0001 versus HC group ) . Western blotting of coronary tissue homogenates for eNOS demonstrated a decrease in protein levels in the HC group compared with the N group , with normalization in the HC+S group . Elevation of plasma F2-isoprostanes and thiobarbituric acid – reactive substances , markers of oxidative stress , occurred in the HC compared with the N group . These changes were reversed in the HC+S group . In summary , simvastatin preserves endothelial function in coronary epicardial vessels and arterioles in experimental HC ( in the absence of cholesterol lowering ) in association with an increase in coronary eNOS levels and a decrease in oxidative stress . These alterations may play a role in the reduction in cardiac events after treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .