Conclusions : Pooled analyses show that barley β-glucan has a lowering effect on LDL-C and non-HDL-C. Inclusion of barley-containing foods may be a strategy for achieving targets in CVD risk reduction
Background / Objectives : There has been recent interest in barley as a therapeutic food owing to its high content of beta-glucan ( β-glucan ) , a viscous soluble fiber recognized for its cholesterol-lowering properties .
The objective of this study was to conduct a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) investigating the cholesterol-lowering potential of barley β-glucan on low-density lipoprotein cholesterol ( LDL-C ) , non-high-density lipoprotein cholesterol ( non-HDL-C ) and apolipoprotein B ( apoB ) for cardiovascular disease ( CVD ) risk reduction .
Beta-glucan- or rice bran-enriched foods: a comparative crossover clinical trial on lipidic pattern in mildly hypercholesterolemic men
Background / Objectives : There has been growing interest in using dietary intervention to improve the lipid profile . This work aims at analyzing the effects and the comparison of the enrichment of a diet with beta-glucans or rice bran in mildly hypercholesterolemic men . Subjects/ Methods : The subjects initially consumed a 3-week Step 1 American Heart Association diet with rice bran-enriched foods . After this adaptation period , volunteers were r and omly assigned to follow a crossover , controlled trial that consisted of two treatment with beta-glucan- or rice bran-enriched foods , each of 4 weeks , with a 3-week wash-out , like the adaptation period , between periods . Fasted blood sample s were collected on days 0 , 21 , 49 , 70 and 98 in both study arms for measuring low-density lipoprotein (LDL)-cholesterol ( primary outcome ) , total cholesterol , high-density lipoprotein (HDL)-cholesterol , triglycerides , apolipoprotein ( apo ) A-I , apo B and glucose levels . Results : Twenty-four men ( mean age : 50.3±5.3 , mean body mass index : 24.9±1.9 ) completed the 14-week trial . Subjects in the 3-week adaptation period experienced significant reductions in the mean level of LDL cholesterol , total cholesterol , total cholesterol/HDL cholesterol , LDL cholesterol/HDL cholesterol , apo A-I , apo A-I/apo B and glucose . During the intervention diet periods , a difference was found between treatment groups for the mean change in LDL ( 0.21 ( 95 % confidence interval ( CI ) : 0.02–0.40 ) , P=0.033 ) and total cholesterol ( 0.34 ( 95 % CI : 0.20–0.47 ) , P<0.001 ) . Other parameters evaluated were not significantly affected by the diet consumed . Conclusions : The results of the present crossover clinical trial showed that beta-glucan-enriched foods are more effective in lowering serum LDL levels , compared with rice bran-enriched foods
Conclusions : Pooled analyses show that barley β-glucan has a lowering effect on LDL-C and non-HDL-C. Inclusion of barley-containing foods may be a strategy for achieving targets in CVD risk reduction
Background / Objectives : There has been recent interest in barley as a therapeutic food owing to its high content of beta-glucan ( β-glucan ) , a viscous soluble fiber recognized for its cholesterol-lowering properties .
The objective of this study was to conduct a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) investigating the cholesterol-lowering potential of barley β-glucan on low-density lipoprotein cholesterol ( LDL-C ) , non-high-density lipoprotein cholesterol ( non-HDL-C ) and apolipoprotein B ( apoB ) for cardiovascular disease ( CVD ) risk reduction .