Quantitative relations between baseline iron status , study duration , and iron dose on changes in iron-status biomarkers , which were generated from the meta-analyses , can be used to predict effects of trials of iron supplementation and fortification and to design iron-intervention programs
BACKGROUND The response of status biomarkers to an increase in iron supply depends on several physiologic and environmental factors , which make it difficult to predict the outcome of an intervention .
OBJECTIVE We assessed effects of baseline iron status , sex , menopausal status , duration of intervention , iron form , and daily dose on the change in iron status in response to iron supplementation .
Can Dietary Treatment of Non-Anemic Iron Deficiency Improve Iron Status?
Objective : To investigate the efficacy of , first , a dietary regimen involving increased consumption of iron-rich foods and enhancers of iron absorption and decreased consumption of inhibitors of iron absorption and , second , a low dose iron chelate iron supplement , for increasing iron stores in young adult New Zeal and women with mild iron deficiency ( MID ) . Methods : The study was a 16 week r and omized placebo-controlled intervention . Seventy-five women aged 18 to 40 years with MID ( serum ferritin < 20 μg/L and hemoglobin ≥120 g/L ) were assigned to one of three groups : Placebo , Supplement ( 50 mg iron/day as amino acid chelate ) or Diet . Participants in the Diet Group were given individual dietary counseling to increase the intake and bioavailability of dietary iron  . Dietary changes were monitored by a previously vali date d computer-administered iron food frequency question naire . Results : Diet Group members significantly increased their intake of flesh foods , heme iron , vitamin C and foods cooked using cast-iron cookware and significantly decreased their phytate and calcium intakes . Serum ferritin increased in the Supplement and Diet Groups by 59 % ( p=0.001 ) and 26 % ( p=0.068 ) , respectively , in comparison to the Placebo Group . The serum transferrin receptor : serum ferritin ratio decreased by 51 % in the Supplement Group ( p=0.0001 ) , and there was a non-significant decrease of 22 % ( p=0.1232 ) in the Diet Group . Conclusions : This study is the first , to our knowledge , to demonstrate that an intensive dietary program has the potential to improve the iron status of women with iron deficiency
Quantitative relations between baseline iron status , study duration , and iron dose on changes in iron-status biomarkers , which were generated from the meta-analyses , can be used to predict effects of trials of iron supplementation and fortification and to design iron-intervention programs
BACKGROUND The response of status biomarkers to an increase in iron supply depends on several physiologic and environmental factors , which make it difficult to predict the outcome of an intervention .
OBJECTIVE We assessed effects of baseline iron status , sex , menopausal status , duration of intervention , iron form , and daily dose on the change in iron status in response to iron supplementation .