While no clinical trial to date has specifically targeted fatigue , r and omized controlled trials , systematic review s , and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue .
Fatigue is a disabling , multifaceted symptom that is highly prevalent and stubbornly persistent .
Although fatigue is a frequent complaint among patients with fibromyalgia , it has not received the same attention as pain .
Reasons for this include lack of st and ardized nomenclature to communicate about fatigue , lack of evidence -based guidelines for fatigue assessment , and a deficiency in effective treatment strategies .
Fatigue does not occur in isolation ; rather , it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain , unrefreshing sleep , anxiety , depression , cognitive difficulties , and so on .
Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms .
Vegetarian diet in the treatment of fibromyalgia.
Brain tryptophan is low in fibromyalgia . Intake of protein rich in large neutral amino acids is reported to lower brain tryptophan . This study was undertaken to assess whether any reduction of such proteins by exclusion of animal protein from the diet reduced pain and morbidity in fibromyalgia patients . It was an open , r and omized controlled trial . 37 subjects with fibromyalgia were enrolled in the vegetarian diet and 41 in the amitriptyline groups .  The outcome was assessed with the help of frequencies of fatigue , insomnia & non-restorative sleep , pain score on a 10-point VAS and tender point count . Fatigue , insomnia and non-restorative sleep were present in 41 , 26 and 32 subjects before and in 3 , 0 and 0 subjects respectively at six weeks of treatment in the amitriptyline group . The pain score and tender point count were 6.2 + /- 1.9 & 16.1 + /- 2.3 before and 2.3 + /- 1.3 & 6.4 + /- 3.0 after treatment . All these differences were significant ( P < 0.001 ) . In the vegetarian diet group , fatigue , insomnia and non-restorative sleep were present in 36 , 24 and 27 subjects before and in 34 , 29 and 29 subjects at six weeks of treatment . The pain score and tender point count were 5.7 + /- 1.8 and 15.7 + /- 2.4 before and 5.0 + /- 1.8 & 14.7 + /- 3.6 after treatment . All these differences were insignificant except that in the pain score . The decrease in the pain score , though significant , was much smaller than that in the amitriptyline group . So , it may be concluded that vegetarian diet is a poor option in the treatment of fibromyalgia
While no clinical trial to date has specifically targeted fatigue , r and omized controlled trials , systematic review s , and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue .
Fatigue is a disabling , multifaceted symptom that is highly prevalent and stubbornly persistent .
Although fatigue is a frequent complaint among patients with fibromyalgia , it has not received the same attention as pain .
Reasons for this include lack of st and ardized nomenclature to communicate about fatigue , lack of evidence -based guidelines for fatigue assessment , and a deficiency in effective treatment strategies .
Fatigue does not occur in isolation ; rather , it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain , unrefreshing sleep , anxiety , depression , cognitive difficulties , and so on .
Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms .