This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .
Postoperative Analgesia by D-myo-Inositol-1,2,6-Trisphosphate in Patients Undergoing Cholecystectomy
D-myo-inositol-1,2,6-trisphosphate ( 1,2,6-IP3 ) possesses antiinflammatory properties , such as reduced eicosanoid synthesis and inhibition of inflammationinduced edema . These properties suggest possible analgesic effects . The analgesic effect of 1,2,6-IP3 was evaluated in a double-blind , r and omized study in 24 patients undergoing cholecystectomy . Ten patients received 1,2,6-IP3 as an intravenous ( IV ) bolus dose of 240 mg , followed by a continuous IV infusion at 90 mg/h for 24 h. The placebo  group ( n = 14 ) received corresponding volumes of isotonic saline .  Postoperative pain ( visual analog pain scale ; VAS ) and opiate analgesic requirements ( ketobemidon )  were evaluated during five postoperative days . Results showed significantly reduced pain during the first five postoperative days in patients treated with 1,2,6-IP ( 3 ) , as measured by using a VAS ( P < 0.05 ) . The requirements of opioid analgesics were significantly reduced during the first three postoperative days ( P < 0.05 ) . No drug-related side effects were observed . Results of the present study demonstrate a potent and long-lasting analgesic effect of 1,2,6-IP3 , possibly related to its antiinflammatory properties . Implication s : A new antiinflammatory drug under investigation , inositol-1,2,6-trisphosphate , was evaluated as a possible analgesic in a pilot study during the postoperative period in cholecystectomized patients . Results showed significantly lower pain assessment and opioid consumption , which should encourage further studies
This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .