Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Association between circulating adiponectin and interleukin-10 levels in android obesity: effects of weight loss.
OBJECTIVE Adiponectin inhibits vascular inflammation and increases IL-10 mRNA expression in human macrophages . Thus , we investigated the possible relationship between plasma adiponectin and IL-10 levels and the effects of a diet-induced moderate weight loss on both cytokines . PATIENTS AND STUDY DESIGN  Plasma adiponectin and IL-10 levels were analyzed in 64 and roid [ body mass index ( BMI ) , > 28 kg/m2 ; waist to hip ratio ( WHR ) , > or = 0.86 ] and 20 gynoid [ BMI , > 28 kg/m2 ; WHR , < 0.86 ] obese healthy women . And roid obese women ( 49 + /- 14 yr ) had a mean BMI of 37.1 + /- 5.3 kg/m2 , similar to that of gynoid obese women ( 49 + /- 11 yr ; BMI , 33.4 + /- 2.6 kg/m2 ) . Twenty nonobese control women ( 46 + /- 11 yr ; BMI , 25.2 + /- 2.2 kg/m2 ) were also studied . In 15 and roid obese women , measurements were repeated after a 12-wk diet period ( 1200 kcal/d ) . RESULTS Median adiponectin [ 5.2 ( range , 3.3 - 7.8 ) vs. 12.1 ( 9.7 - 13.9 ) vs. 15.0 ( 12.6 - 18.2 ) microg/ml ; P < 0.0001 ] and IL-10 [ 1.8 ( 1.2 - 3.3 ) vs. 3.5 ( 2.9 - 4.3 ) and vs. 4.1 ( 3.5 - 4.8 ) pg/ml ; P < 0.0001 ] levels were lower in and roid vs. gynoid vs. nonobese women . Among and roid obese women , low adiponectin levels were independently related ( P < 0.0001 ) to decreased IL-10 levels , independently of BMI , WHR , or insulin resistance . No significant change in either median adiponectin or IL-10 levels was observed after body weight reduction ( 8 + /- 4 kg ; P < 0.01 ) , although percent changes in adiponectin paralleled those in IL-10 ( P < 0.05 ) . CONCLUSIONS And roid obesity is associated with a concomitant reduction of IL-10 and adiponectin levels . However , the antiinflammatory status of obesity might require prolonged periods of energy-restricted diets to revert to normal
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .