The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
The effect of A Triclosan/copolymer/fluoride dentifrice on plaque formation and gingivitis: a six-month clinical study.
A total of 108 adult male and female subjects completed a six-month , double-blind clinical study design ed to compare the effect of a dentifrice containing 0.3 % triclosan and 2.0 % of a copolymer of methoxyethylene and maleic acid ( Gantrez copolymer ) in a 0.243 % sodium fluoride/silica base to a 0.243 % sodium fluoride/silica placebo dentifrice on supragingival plaque formation and gingivitis . Subjects were stratified into two balanced groups by their baseline plaque and gingivitis scores . They received an oral prophylaxis and were assigned to use either the triclosan/copolymer dentifrice or the placebo dentifrice for the next six months . After six months , the dentifrice containing triclosan/copolymer provided a 24.93 % statistically significant ( 99 % level of confidence ) reduction in supragingival plaque , and a 19.72 % statistically significant ( 99 % level of confidence ) reduction in gingivitis compared to the placebo dentifrice . Twice daily use of a dentifrice containing 0.3 % triclosan , 2.0 % of a copolymer , and 0.243 % sodium fluoride in a silica base , over a six-month period , reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .