This meta- analysis demonstrated that resveratrol supplementation among patients with MetS and related disorders  significantly reduced total cholesterol and increased GGT concentrations , but did not affect triglycerides , LDL- , HDL-cholesterol , ALT , and AST concentrations .
This data suggests that resveratrol may have a potential cardio-protective effect in patients with MetS and related disorders
There are current trials investigating the effect of resveratrol supplementation on lipid profiles and liver enzymes among patients with metabolic syndrome ( MetS ) and related disorders ; however , their findings are controversial .
This systematic review and meta- analysis were aim ed to determine the effects of resveratrol supplementation on lipid profiles and liver enzymes among patients with MetS and related disorders .
Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial.
BACKGROUND The obese insulin-resistant state is characterized by impairments in lipid metabolism . We previously showed that 3-d supplementation of combined epigallocatechin-3-gallate and resveratrol ( EGCG+RES ) increased energy expenditure and improved the capacity to switch from fat toward carbohydrate oxidation with a high-fat mixed meal ( HFMM ) test in men . OBJECTIVE The present study aim ed to investigate the longer-term effect of EGCG+RES supplementation on metabolic profile , mitochondrial capacity , fat oxidation , lipolysis , and tissue-specific insulin sensitivity . DESIGN In this r and omized double-blind study , 38 overweight and obese subjects [ 18 men ; aged 38 ± 2 y ; body mass index ( kg/m(2 ) ) : 29.7 ± 0.5 ] received either EGCG+RES ( 282 and 80 mg/d , respectively ) or placebo for 12 wk . Before and after the intervention , oxidative capacity and gene expression were assessed in skeletal muscle . Fasting and postpr and ial ( HFMM ) lipid metabolism was assessed by using indirect calorimetry , blood sampling , and microdialysis . Tissue-specific insulin sensitivity was assessed by a hyperinsulinemic-euglycemic clamp with [6,6-(2)H2]-glucose infusion . RESULTS EGCG+RES supplementation did not affect the fasting plasma metabolic profile . Although whole-body fat mass was not affected , visceral adipose tissue mass tended to decrease after the intervention compared with placebo ( P-time × treatment = 0.09 ) . EGCG+RES supplementation significantly increased oxidative capacity in permeabilized muscle fibers ( P-time × treatment < 0.05 , P-EGCG+RES < 0.05 ) . Moreover , EGCG+RES  reduced fasting ( P-time × treatment = 0.03 ) and postpr and ial respiratory quotient ( P-time × treatment = 0.01 ) compared with placebo . Fasting and postpr and ial fat oxidation was not significantly affected by EGCG+RES ( P-EGCG+RES = 0.46 and 0.38 , respectively ) but declined after placebo ( P-placebo = 0.05 and 0.03 , respectively ) . Energy expenditure was not altered ( P-time × treatment = 0.96 ) . Furthermore , EGCG+RES supplementation attenuated the increase in plasma triacylglycerol concentrations during the HFMM test that was observed after placebo ( P-time × treatment = 0.04 , P-placebo = 0.01 ) . Finally , EGCG+RES had no effect on insulin-stimulated glucose disposal , suppression of endogenous glucose production , or lipolysis . CONCLUSION Twelve weeks of EGCG+RES supplementation increased mitochondrial capacity and stimulated fat oxidation compared with placebo , but this did not translate into increased tissue-specific insulin sensitivity in overweight and obese subjects . This trial was registered at clinical trials.gov as NCT02381145
This meta- analysis demonstrated that resveratrol supplementation among patients with MetS and related disorders  significantly reduced total cholesterol and increased GGT concentrations , but did not affect triglycerides , LDL- , HDL-cholesterol , ALT , and AST concentrations .
This data suggests that resveratrol may have a potential cardio-protective effect in patients with MetS and related disorders
There are current trials investigating the effect of resveratrol supplementation on lipid profiles and liver enzymes among patients with metabolic syndrome ( MetS ) and related disorders ; however , their findings are controversial .
This systematic review and meta- analysis were aim ed to determine the effects of resveratrol supplementation on lipid profiles and liver enzymes among patients with MetS and related disorders .