The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
Effect of listerine on dental plaque and gingivitis.
The present study was performed in 10 adults in order to evaluate the effect of an antiseptic mouthrinse ( Listerine ) on the rate of dental plaque formation and gingivitis development during a 2-week period when all efforts towards active mechanical oral hygiene were withdrawn . The study was performed as a crossover study and was carried out during four consecutive 2-week periods . During the first and third periods ( preparatory periods ) the participants were subjected to repeated professional tooth cleanings in order to establish plaque- and gingivitis-free dentitions . During the second and fourth periods ( test and control periods ) the participants were not allowed to brush their teeth but rinsed their mouths three times a day with Listerine or a placebo mouthwash .  Plaque Index , Gingival Index , gingival fluid flow , and crevicular leukocytes were assessed on d 0 , 2 , 4 , 7 , and 14 . On d 7 and 14 , dental plaque was removed from the right and left jaws respectively and the wet weights determined . The chemotactic activity elaborated by the plaques was studied in Boyden chambers . During the Listerine test period , significantly lower Plaque and Gingival Index values were scored and lower amounts of plaque could be sample d in comparison to the control period
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .