The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .
Reduction of resistance artery stiffness by treatment with the AT1-receptor antagonist losartan in essential hypertension
In spontaneously hypertensive rats resistance artery structure , endothelial dysfunction and geometry-independent wall stiffness were reduced by an angiotensin AT1-receptor antagonist . In previous studies of human hypertension , interruption of the renin-angiotensin system corrected small artery structure and endothelial dysfunction , whereas the β-blocker atenolol did not . We hypothesized that the AT1R antagonist losartan , but not the β-blocker atenolol , would reduce stiffness of gluteal subcutaneous small arteries in essential hypertensive patients . Seventeen untreated mild essential hypertensive patients ( 47±2years ; 75 % male ) were r and omly assigned in double-blind fashion to losartan or atenolol treatment for one year . Small , resistance size arteries were studied on pressurized myographs . Blood pressure ( mmHg ) was reduced ( p<0.01 ) from 145±4/101±2 and 147±6/98±2 to 128±4/86±2 and 131±3/84±1 by losartan and atenolol , respectively . The media/lumen ratio of small arteries was unaffected by atenolol ( 8.3±0.3 % before and 8.8±0.5 % after treatment ) . In contrast , losartan reduced media/lumen ratio from 8.4±0.4 % to 6.7±0.3 % ( p<0.01 ) . Whereas isobaric elastic modulus was unaffected by either treatment , geometry-independent stiffness ( slope of elastic modulus vs. stress ) was reduced from 9.7±1.2 to 6.1±0.9 ( P<0.05 ) under losartan treatment , but was unchanged by atenolol ( 8.2±1.3 to 7.8±0.6 ) . In conclusion , treatment with losartan reduced stiffness and structural alterations of subcutaneous resistance arteries of previously untreated essential hypertensive patients , whereas atenolol failed to do so
The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .