( S ) Few studies of medical therapies for endometriosis report outcomes that are relevant to patients , and many women gain only limited or intermittent benefit from treatment
OBJECTIVE To assess patient response rates to medical therapies used to treat endometriosis-associated pain .
Prospective randomized double-blind trial of 3 versus 6 months of nafarelin therapy for endometriosis associated pelvic pain.
OBJECTIVES To determine the effectiveness of a 3-month course of nafarelin and , furthermore , to determine the long-term efficacy in patients treated for 3 and 6 months with nafarelin for symptoms associated with endometriosis . DESIGN Double-blind , prospect i ve , multicenter , clinical trial . SETTING Fifteen reproductive endocrine clinics throughout the United States . PATIENTS One hundred seventy-nine women with pelvic pain and endometriosis . INTERVENTIONS Patients were assigned r and omly to 3 months nafarelin followed by 3 months of placebo ( n = 91 ) or to 6 months nafarelin ( n = 88 ) in a prospect i ve , r and omized , double-blind multicenter trial . Patients were followed for 12 months after cessation of therapy . MAIN OUTCOME MEASURES Patient-reported pain scores and physician-reported physical exam findings . RESULTS Pain scores dropped significantly by the end of treatment in both groups . Symptoms recurred in both groups , and pain scores gradually increased during the follow-up period but always remained below baseline in both groups . No significant difference in efficacy was noted between the groups . A total of 26 % of patients in each group underwent retreatment for recurrent symptoms . CONCLUSIONS A 3-month course of nafarelin provided effective symptom relief for endometriosis . One year follow-up demonstrated continued pain relief but with gradual return of symptoms
( S ) Few studies of medical therapies for endometriosis report outcomes that are relevant to patients , and many women gain only limited or intermittent benefit from treatment
OBJECTIVE To assess patient response rates to medical therapies used to treat endometriosis-associated pain .