In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .
Cephalic phase insulin release in healthy humans after taste stimulation?
In humans little is known as to whether taste solutions applied to the tongue elicit cephalic phase insulin release ( CPIR ) . The aim of this study was to re-examine if any effect of different taste solutions on CPIR occurs . Under fasting conditions healthy human subjects sipped , and washed out their mouths with eight taste solutions ( sucrose , saccharin , acetic acid , sodium chloride , quinine hydrochloride , distilled water , starch , and sodium glutamate ) for 45 s and spat them out again . The taste stimuli were not swallowed ; they were applied in a r and omized order , each on a separate day . Blood collection for determination of plasma glucose and plasma insulin concentrations was performed 3 min before and 3 , 5 , 7 and 10 min after taste stimulation . Ratings of quality , intensity and hedonic characteristics were also obtained . A significant increase of plasma insulin concentration was apparent after stimulation with sucrose and saccharin . In conclusion , the current data suggest that the sweeteners sucrose and saccharin activate a CPIR even when applied to the oral cavity only
In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .