Prolonged antioxidant vitamin E and /or C supplementation could be effective to improve endothelial function in non-obese T2DM subjects
Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus ( T2DM ) subjects .
The aim of this study was to systematic ally review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects .
Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease.
OBJECTIVE To examine the effect of vitamin C on forearm vasodilatory response to reactive hyperemia and on plasma level of plasminogen activator inhibitor 1 ( PAI-1 ) , von Willebr and factor ( vWF ) , tissue plasminogen activator ( tPA ) , antithrombin III ( ATIII ) , proteins C and S , and factors V ( fV ) and VII ( fVII ) in patients with both type 2 diabetes and CAD . RESEARCH DESIGN AND METHODS A total of 39 patients with type 2 diabetes and CAD were divided into two groups and received vitamin C ( 2 g/day ) or no antioxidant for 4 weeks . Forearm blood flow was determined using venous occlusion gauge-strain plethysmography at baseline and after treatment . Forearm vasodilatory response to reactive hyperemia ( RH% ) or nitrate ( NTG% ) was defined as the percent change of flow from baseline to the maximum flow during reactive hyperemia or after administration of nitrate , respectively . Biochemical markers were determined by enzyme-linked immunosorbent assay ( ELISA ) or other st and ard methods . RESULTS RH% was significantly increased after treatment with vitamin C ( from 62.4 + /- 7.2 to 83.1 + /- 9.3 % , P = 0.024 ) but remained unaffected in the control group . Vitamin C decreased plasma levels of fV ( from 143 + /- 5.4 to 123 + /- 6.03 % , P = 0.038 ) , vWF ( from 133.5 + /- 14.5 to 109.5 + /- 11.4 % , P = 0.016 ) , and tPA ( from 12.3 + /- 0.99 to 8.40 + /- 0.60 ng/ml , P = 0.001 ) , whereas these levels remained unaffected in the control group . The changes in RH% , vWF , and tPA were significantly greater ( P = 0.028 , 0.036 , and 0.007 , respectively ) in the vitamin C-treated group than in the control group . Levels of ATIII , proteins S and C , fVII , and PAI-1 remained unchanged in all groups . CONCLUSIONS Short-term treatment with high doses of vitamin C improved RH% and decreased plasma levels of tPA and vWF in patients with type 2 diabetes and CAD
Prolonged antioxidant vitamin E and /or C supplementation could be effective to improve endothelial function in non-obese T2DM subjects
Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus ( T2DM ) subjects .
The aim of this study was to systematic ally review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects .