Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .
Eradication of Helicobacter pylori affects symptoms in non-ulcer dyspepsia.
BACKGROUND The relationship between Helicobacter pylori infection and non-ulcer dyspepsia is controversial . METHODS In a prospect i ve , long-term , double-blind study we r and omized 100 patients with non-ulcer dyspepsia and H. pylori infection to receive either of two treatment regimens : 1 ) bismuth-based triple therapy ( n = 50 ) or 2 ) bismuth + placebo ( n = 50 ) . RESULTS Triple therapy : subjects who became H. pylori-negative ( n = 42 ) showed a significant symptomatic response when interviewed at 8 weeks , 6 months , and 1 year ( P < 0.01 ) . This improvement was evident in the ' ulcer-like ' dyspepsia group at all times ( P < 0.01 ) but in the ' reflux-like ' and ' motility-like ' groups at 6 months only ( P < 0.01 ) . Those who remained H. pylori-positive showed no decrease in symptoms at 8 weeks , 6 months , and 1 year . Bismuth-placebo therapy : subjects who became H. pylori-negative ( n = 7 ) showed an improvement in symptoms at 8 weeks , 6 months , and 1 year . Those who continued to harbour the infection after treatment ( n = 42 ) showed an insignificant improvement in the motility and non-specific groups only . CONCLUSION This study shows that eradication of H. pylori results in a significant long-term reduction in symptoms of non-ulcer dyspepsia
Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .