In general , when given alongside gestational weight gain advice , fasting glucose improved in most diets compared to diets that gave gestational weight gain advice only .
However , fasting glucose increased in high unsaturated or monounsaturated fatty acids diets .
In the absence of gestational weight gain advice , fasting glucose improved in DASH-style diets compared to st and ard of care .
Although most were non-significant , similar trends were observed for these same diets for the other glycemic outcomes .
/INTERPRETATION Alongside with gestational weight gain advice , most diets , with the exception of a high unsaturated or a high monounsaturated fatty acid diet , demonstrated a fasting glucose improvement compared with gestational weight gain advice only .
When gestational weight gain advice was not given , the DASH-style diet appeared optimal on fasting glucose .
However , a small number of trials were identified and most dietary comparisons were underpowered to detect differences in glycemic outcomes .
AIMS Evidence to support dietary modifications to improve glycemia during pregnancy is limited , and the benefits of diet beyond limiting gestational weight gain is unclear .
Therefore , a systematic review and network meta- analysis of r and omized trials was conducted to compare the effects of various common diets , stratified by the addition of gestational weight gain advice , on fasting glucose and insulin , hemoglobin A1c ( HbA1c ) , and homeostatic model assessment for insulin resistance ( HOMA-IR ) in pregnant women .
Early Second Trimester Maternal Plasma Choline and Betaine Are Related to Measures of Early Cognitive Development in Term Infants
Background The importance of maternal dietary choline for fetal neural development and later cognitive function has been well-documented in experimental studies . Although choline is an essential dietary nutrient for humans , evidence that low maternal choline in pregnancy impacts neurodevelopment in human infants is lacking . We determined potential associations between maternal plasma free choline and its metabolites betaine and dimethylglycine in pregnancy and infant neurodevelopment at 18 months of age . Methodology This was a prospect i ve study of healthy pregnant women and their full-term , single birth infants . Maternal blood was collected at 16 and 36 weeks of gestation and infant neurodevelopment was assessed at 18 months of age for 154 mother-infant pairs .  Maternal plasma choline , betaine , dimethylglycine , methionine , homocysteine , cysteine , total B12 , holotranscobalamin and folate were quantified . Infant neurodevelopment was evaluated using the Bayley Scales of Infant Development – III . Multivariate regression , adjusting for covariates that impact development , was used to determine the associations between maternal plasma choline , betaine and dimethylglycine and infant neurodevelopment . Results The maternal plasma free choline at 16 and 36 weeks gestation was median ( interquartile range ) 6.70 ( 5.78–8.03 ) and 9.40 ( 8.10–11.3 ) µmol/L , respectively . Estimated choline intakes were ( mean ±SD ) 383±98.6 mg/day , and lower than the recommended 450 mg/day . Betaine intakes were 142±70.2 mg/day . Significant positive associations were found between infant cognitive test scores and maternal plasma free choline ( B = 6.054 , SE = 2.283 , p = 0.009 ) and betaine ( B = 7.350 , SE = 1.933 , p = 0.0002 ) at 16 weeks of gestation . Maternal folate , total B12 , or holotranscobalamin were not related to infant development . Conclusion We show that choline status in the first half of pregnancy is associated with cognitive development among healthy term gestation infants . More work is needed on the potential limitation of choline or betaine in the diets of pregnant women
In general , when given alongside gestational weight gain advice , fasting glucose improved in most diets compared to diets that gave gestational weight gain advice only .
However , fasting glucose increased in high unsaturated or monounsaturated fatty acids diets .
In the absence of gestational weight gain advice , fasting glucose improved in DASH-style diets compared to st and ard of care .
Although most were non-significant , similar trends were observed for these same diets for the other glycemic outcomes .
/INTERPRETATION Alongside with gestational weight gain advice , most diets , with the exception of a high unsaturated or a high monounsaturated fatty acid diet , demonstrated a fasting glucose improvement compared with gestational weight gain advice only .
When gestational weight gain advice was not given , the DASH-style diet appeared optimal on fasting glucose .
However , a small number of trials were identified and most dietary comparisons were underpowered to detect differences in glycemic outcomes .
AIMS Evidence to support dietary modifications to improve glycemia during pregnancy is limited , and the benefits of diet beyond limiting gestational weight gain is unclear .
Therefore , a systematic review and network meta- analysis of r and omized trials was conducted to compare the effects of various common diets , stratified by the addition of gestational weight gain advice , on fasting glucose and insulin , hemoglobin A1c ( HbA1c ) , and homeostatic model assessment for insulin resistance ( HOMA-IR ) in pregnant women .