It was concluded that sesame consumption can significantly reduce blood TAG levels but there is insufficient evidence to support its hypocholesterolaemic effects .
Increased plasma lipid profiles are among the most important risk factors of CHD and stroke .
Sesame contains considerable amounts of vitamin E , MUFA , fibre and lignans , which are thought to be associated with its plasma lipid-lowering properties .
Effect of sesame seed on lipid profile and redox status in hyperlipidemic patients
Pre- clinical studies suggest that sesame and its lignans induce beneficial changes in risk factors related to cardiovascular disease . This study was design ed to investigate the effects of sesame on reducing serum lipids and enhancing antioxidant capacity in 38 hyperlipidemic patients who were divided into two groups r and omly . For all individuals along the 60 days of study period , the same drug treatments were considered . Intervention group patients were supposed to eat 40 g white sesame seeds daily , and instead of these calories , 240 kcal was removed from their diet . Anthropometric measurements including height , weight and body mass index ( BMI ) were measured . We assessed lipid profile and oxidative stress indicators such as glutathione peroxidase ( GPX ) , superoxide dismutase ( SOD ) and thiobarbituric acid reactive substances ( TBARS ) before and after the intervention . Significant differences among and between the groups were determined by independent t-test and paired sample t-test using 13th version of statistical package for the social sciences . The results showed that the diet with sesame significantly decreased the levels of serum total cholesterol ( TC ) and low-density lipoprotein cholesterol ( LDL-C ) and TC/HDL-C ratio . Lipid peroxidation ( TBARS ) decreased while the activities of GPX and SOD were increased . There were no significant changes in anthropometric indexes such as weight and BMI after consumption of sesame . The results suggested that sesame seed supplementation decreased serum TC , LDL-C and lipid peroxidation , and increased antioxidant status in hyperlipidemic patients
It was concluded that sesame consumption can significantly reduce blood TAG levels but there is insufficient evidence to support its hypocholesterolaemic effects .
Increased plasma lipid profiles are among the most important risk factors of CHD and stroke .
Sesame contains considerable amounts of vitamin E , MUFA , fibre and lignans , which are thought to be associated with its plasma lipid-lowering properties .