There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Molecular Fingerprints of the Human Fecal Microbiota From 9 to 18 Months Old and the Effect of Fish Oil Supplementation
Objectives : The aim of this study was to monitor changes in the fecal microbiota from 9 to 18 months and to investigate the effect of increasing dietary n-3 polyunsaturated fatty acids on the fecal microbiota . Patients and Methods : In a double-blind controlled trial with r and om allocation to daily supplementation with 5 mL of fish oil ( FO ) or sunflower oil ( SO ) from 9 to 18 months of age , stool sample s were collected from 132 healthy Danish infants .  Molecular fingerprints of the bacterial DNA were obtained by terminal restriction fragment length polymorphism ( T-RFLP ) . Results : The T-RFLP profiles indicated that a few T-RFs became dominant with age ( bp100 and 102 , both presumed to be Bacteroidetes ) concomitantly with an overall increase in the microbial diversity ( P = 0.04 ) . Breast-feeding influenced both the T-RFLP profiles at 9 months and the changes from 9 to 18 months , and breast-feeding cessation during the trial modified the response to the dietary oils . In the FO group , the increase in bp102 was significantly reduced among children weaned before compared with those weaned during the trial ( P = 0.027 ) , whereas the increase in bp100 was reduced in the preweaned children of the SO group relative to those weaned during the trial ( P = 0.004 ) . This was supported by intervention group differences in the changes in bp102 and bp100 among the earlier weaned children ( P = 0.06 and P = 0.09 , respectively ) . Conclusions : Cessation of breast-feeding played a dominant role relative to developmental changes in the fecal microbiota from 9 to 18 months . FO compared with SO supplementation affected changes in large bacterial groups , but only among children who had stopped breast-feeding before 9 months of age
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .