There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Effect of Dietary Omega-3 Fatty Acids on Retinal Function of Very-Low-Birth-Weight Neonates
ABSTRACT : Retinal function was assessed by electroretinogram in 32 neonates r and omly assigned to formulas of different ω-3 fatty acid content and in 10 infants fed human milk . All neonates had a birth weight of 1000 - 1500 g and were fed study diets from d 10 to 45 or discharge . Group A received formula containing predominantly 18:2 ω-6 . Group B received a balanced mix of 18:2 ω-6 and 18:3 ω- 3 . Group C was given a formula containing both essential fatty acids and supplemented with marine oil to provide 22:6 ω-3 content similar to that of human milk . The fatty acid composition of plasma and red blood cell ( RBC ) lipids were similar for all groups on entry but marked dietinduced differences were found after feeding the study diets . Group C was comparable to the human milk-fed group , but group A had lower 22:6 ω-3 and ω-3 long-chain polyunsaturated fatty acids ( LCPUFA ) in plasma and RBC membranes . Cone function was not affected by dietary essential fatty acids . Rod electroretinogram thresholds were significantly higher for group A relative to the human milk-fed group and group C and significantly correlated with RBC ω-3 LCPUFA ( r = -0.63 , p < 0.0001 ) ; 44 % of the variance could be explained by RBC and plasma ω-3 LCPUFA content . Rod electroretinogram amplitude was significantly lower for group A relative to the human milkfed group and group C and related to plasma 22:6 ω-3 ( r = 0.55 ) and total ω-3 LCPUFA ( r = 0.58 ) ( both p < 0.0001 ) ; 42 % of the variance was explained by plasma ω-3 LCPUFA , the ratio of ω-6/ω-3 LCPUFA in RBC , and gestational age at birth . Our results support an essential role for ω-3 fatty acids in retinal development
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .