Outcomes , such as range of motion , recurrence , and clinical success , were frequently defined , however many different definitions were used .
This systematic review summarizes the outcome reporting st and ards in Dupuytren ’s disease treatment research .
Treatment of Recurrent Dupuytren Contracture in Joints Previously Effectively Treated With Collagenase Clostridium histolyticum.
PURPOSE Collagenase Clostridium histolyticum ( CCH ) is approved for the treatment of adults with Dupuytren contracture with a palpable cord . This open-label , phase 4 study evaluated the safety and efficacy of CCH for the retreatment of recurrent contractures in joints that were previously effectively treated with CCH . METHODS Patients participating in a long-term follow-up study who had contracture recurrence ( increased ≥ 20 ° with a palpable cord ) after successful treatment in the previous study were eligible . Recurrent joint contractures were treated with up to 3 CCH injections ( ∼ 1 month apart ) . Patients were followed for 1 year to evaluate safety . Assessment s included change in joint contracture , range of motion , and the percentage of joints that achieved contracture of 5 ° or less at day 30 after the last injection . RESULTS The efficacy analysis included 51 patients with 1 treated joint per patient ( 31 metacarpophalangeal , 20 proximal interphalangeal ) . A total of 35 joints ( 69 % ) received 1 injection , 12 ( 24 % ) received 2 injections , and 4 ( 8 % ) received 3 injections . Fifty-seven percent of joints achieved contracture of 5 ° or less ( 29 of 51 ) . Overall , 86 % ( 43 of 50 ) patients had a 20 ° or greater increase in range of motion . The adverse event profile was consistent with previous studies . One ligament injury was reported . CONCLUSIONS At a short-term follow-up of 1 year , recurrent contracture in joints previously successfully treated with CCH may be effectively retreated with up to 3 injections of CCH . TYPE OF STUDY /LEVEL OF EVIDENCE Therapeutic IV
Outcomes , such as range of motion , recurrence , and clinical success , were frequently defined , however many different definitions were used .
This systematic review summarizes the outcome reporting st and ards in Dupuytren ’s disease treatment research .