There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Enhanced Feeding and Diminished Postnatal Growth Failure in Very-Low-Birth-Weight Infants
Objective : The aim of the present study was to determine whether an increased supply of energy , protein , essential fatty acids , and vitamin A reduces postnatal growth failure in very-low-birth-weight infants . Methods : Fifty infants with birth weight < 1500 g were r and omized to an intervention ( n = 24 ) or a control ( n = 26 ) feeding protocol within 24 hours after birth . Forty-four infants were included in the final analysis . This study was discontinued because of an increased occurrence of septicemia in the intervention group . Results : The intervention group had a lower mean birth weight ( P = 0.03 ) and a higher proportion of infants small-for-gestational age  ( P = 0.04 ) than the control group . Other baseline characteristics were similar . The median ( interquartile range ) energy and protein supplies during the first 4 weeks of life were higher in the intervention group : 139 ( 128–145 ) versus 126 ( 121–128 ) kcal · kg−1 · day−1 ( P < 0.001 ) and 4.0 ( 3.9–4.2 ) versus 3.2 ( 3.1–3.3 ) g · kg−1 · day−1 ( P < 0.001 ) . The infants in the intervention group regained birth weight faster ( P = 0.001 ) and maintained their z scores for weight and head circumference from birth to 36 weeks ’ postmenstrual age ( both P < 0.001 ) . The median ( interquartile range ) growth velocity was 17.4 ( 16.3–18.6 ) g · kg−1 · day−1 in the intervention group and 13.8 ( 13.2–15.5 ) g · kg−1 · day−1 in the control group ( P < 0.001 ) . In line with the improved growth in the intervention group , the proportion of growth-restricted infants was 11 of 23 both at birth and at 36 weeks ’ postmenstrual age , whereas this proportion increased among the controls from 4 of 21 to 13 of 21 ( P = 0.04 ) . Conclusions : Enhanced supply of energy , protein , essential fatty acids , and vitamin A caused postnatal growth along the birth percentiles for both weight and head circumference
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .