In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Effect of acacia polyphenol on glucose homeostasis in subjects with impaired glucose tolerance: A randomized multicenter feeding trial
Numerous in vitro and animal studies , as well as clinical trials have indicated that plant-derived polyphenols exert beneficial effects on glucose intolerance or type 2 diabetes .  This clinical study aim ed to investigate the effects of acacia polyphenol ( AP ) on glucose and insulin responses to an oral glucose tolerance test ( OGTT ) in non-diabetic subjects with impaired glucose tolerance ( IGT ) . A r and omized , double-blind , placebo-controlled trial was conducted in a total of 34 enrolled subjects . The subjects were r and omly assigned to the AP-containing dietary supplement ( AP supplement ; in a daily dose of 250 mg as AP ; n=17 ) or placebo ( n=17 ) and the intervention was continued for 8 weeks . Prior to the start of the intervention ( baseline ) and after 4 and 8 weeks of intervention , plasma glucose and insulin were measured during a two-hour OGTT . Compared with the baseline , plasma glucose and insulin levels at 90 and /or 120 min , as well as the total area under the curve values during the OGTT ( AUC0→2h ) for glucose and insulin , were significantly reduced in the AP group , but not in the placebo group after intervention for 8 weeks . The decline from baseline in plasma glucose and insulin at 90 or 120 min of the OGTT for the AP group was significantly greater compared with that of the placebo group after 8 weeks of intervention . No AP supplement-related adverse side-effects nor any abnormal changes in routine laboratory tests and anthropometric parameters were observed throughout the study period . The AP supplement may have the potential to improve glucose homeostasis in subjects with IGT
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .