The antihypertensive efficacy of HCTZ in its daily dose of 12.5 to 25 mg as measured in head-to-head studies by ambulatory BP measurement is consistently inferior to that of all other drug classes .
Because outcome data at this dose are lacking , HCTZ is an inappropriate first-line drug for the treatment of hypertension
OBJECTIVES The purpose of this study was to evaluate the antihypertensive efficacy of hydrochlorothiazide ( HCTZ ) by ambulatory blood pressure ( BP ) monitoring .
BACKGROUND HCTZ is the most commonly prescribed antihypertensive drug worldwide .
More than 97 % of all HCTZ prescriptions are for 12.5 to 25 mg per day .
The antihypertensive efficacy of HCTZ by ambulatory BP monitoring is less well defined .
Comparison of atenolol, amlodipine, enalapril, hydrochlorothiazide, and losartan for antihypertensive treatment in patients with obstructive sleep apnea.
We compared the effects of atenolol ( 50 mg ) , amlodipine ( 5 mg ) , enalapril ( 20 mg ) , hydrochlorothiazide ( 25 mg ) , and losartan ( 50 mg ) given in once-daily oral doses on office and ambulatory blood pressures ( BPs ) in patients with hypertension and obstructive sleep apnea ( OSA ) . Each of 40 r and omized patients was treated in sequence with two of the five agents ( balanced incomplete block design ) . Treatment periods lasted 6 wk and were separated by a 3-wk washout period . Changes in BP from baseline with the study substances were compared through analysis of variance . Office diastolic BP , our primary outcome variable , was most effectively lowered by atenolol , with all four post hoc differences between atenolol and the remaining substances being statistically significant . Reductions in office systolic and daytime ambulatory BP were not significantly different among the five compounds . However , atenolol reduced mean nighttime ambulatory diastolic and systolic BP more effectively than did amlodipine , enalapril , or losartan ( but not hydrochlorothiazide ) . Severity of sleep-disordered breathing and well-being during the day were not significantly influenced by any of the study compounds . Our findings are in accordance with the hypothesis that an overactivity of the sympathetic nervous system is an important mechanism behind the development or maintenance of hypertension in patients with OSA
The antihypertensive efficacy of HCTZ in its daily dose of 12.5 to 25 mg as measured in head-to-head studies by ambulatory BP measurement is consistently inferior to that of all other drug classes .
Because outcome data at this dose are lacking , HCTZ is an inappropriate first-line drug for the treatment of hypertension
OBJECTIVES The purpose of this study was to evaluate the antihypertensive efficacy of hydrochlorothiazide ( HCTZ ) by ambulatory blood pressure ( BP ) monitoring .
BACKGROUND HCTZ is the most commonly prescribed antihypertensive drug worldwide .
More than 97 % of all HCTZ prescriptions are for 12.5 to 25 mg per day .
The antihypertensive efficacy of HCTZ by ambulatory BP monitoring is less well defined .