SAMe was not different from placebo and established antidepressants .
The exception was that compared to imipramine , fewer participants experienced troublesome adverse effects when treated with parenteral SAMe .
BACKGROUND Depression is a recurrent illness with high rates of chronicity , treatment-resistance and significant economic impact .
There is evidence in the literature that S-adenosyl methionine ( SAMe ) , a naturally occurring compound in the human body , has antidepressant efficacy .
This product may be an important addition to the armamentarium of antidepressant agents .
OBJECTIVES To assess the effects of SAMe in comparison with placebo or antidepressants for the treatment of depression in adults .
The thyrotropin response to thyrotropin‐releasing hormone as a predictor of response to treatment in depressed outpatients
We evaluated the predictive value of the thyrotropin ( TSH ) response to thyrotropin‐releasing hormone ( TRH ) in 32 depressed out patients completing a double‐blind placebo‐controlled trial of s‐adenosyl‐l‐methionine ( SAMe )  , which failed to show any significant difference between SAMe and placebo . Treatment response was defined as the change in Hamilton Rating Scale for Depression ( HRSD‐24 ) score between baseline and the end of the six‐week trial . Subjects with TSH response outside the normal range ( 7–25 uU/ml ) had a significantly greater response than patients with a normal response . There was also a significant correlation between absolute deviations from the mean TSH response ( 16 uU/ml ) and changes in HRSD‐24 scores
SAMe was not different from placebo and established antidepressants .
The exception was that compared to imipramine , fewer participants experienced troublesome adverse effects when treated with parenteral SAMe .
BACKGROUND Depression is a recurrent illness with high rates of chronicity , treatment-resistance and significant economic impact .
There is evidence in the literature that S-adenosyl methionine ( SAMe ) , a naturally occurring compound in the human body , has antidepressant efficacy .
This product may be an important addition to the armamentarium of antidepressant agents .
OBJECTIVES To assess the effects of SAMe in comparison with placebo or antidepressants for the treatment of depression in adults .