The EQ-5D and SF-36 achieved mixed results in the quantitative testing against psychometric criteria .
The qualitative analysis suggests this is because they provide a very limited coverage of themes identified by people with mental health problems .
BACKGROUND Generic preference-based measures of health like the EQ-5D and SF-6D ( ® ) are increasingly being used in economic evaluation and outcome assessment .
However , there are concerns as to whether or not these generic measures are appropriate for use in people with mental health problems .
OBJECTIVES The EQ-5D and SF-36 ( ® ) ( including its derivatives the SF-12 ( ® ) and SF-6D ) were assessed using the psychometric criteria of validity and responsiveness using quantitative and qualitative methods .
Another aim was to estimate mapping functions between the EQ-5D and SF-6D and condition-specific measures , where appropriate .
Effects of olanzapine alone and olanzapine/fluoxetine combination on health-related quality of life in patients with bipolar depression: secondary analyses of a double-blind, placebo-controlled, randomized clinical trial.
BACKGROUND Improving patients '  health-related quality of life ( HRQOL ) could be a treatment goal for bipolar depression . OBJECTIVES The objectives of these secondary analyses of a previous report were to determine the benefits of olanzapine alone and olanzapine-fluoxetine combination ( OFC ) for improving HRQOL in patients with bipolar depression using both a generic and a depression-specific HRQOL instrument , and to examine the association between the 2 HRQOL instruments and the construct validity of the depression-specific HRQOL instrument . METHODS This was a double-blind , placebo-controlled , 83-site , international , r and omized trial . Adults with bipolar I disorder , most recent episode depressed ( according to the Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition ) , were r and omly assigned to receive olanzapine ( 6 - 20 mg/d ) , OFC ( 6/25 , 12/25 , or 12/50 mg/d ) , or placebo for 8 weeks . HRQOL improvement was calculated as last-observation-carried-forward changes in dimension and component summary scores on Medical Outcomes Study 36-Item Short-Form Health Survey ( SF-36 ) and total score on the Quality of Life in Depression Scale ( QLDS ) . RESULTS Patients were assigned to receive olanzapine ( n = 370 ) , [ corrected ] OFC ( n = 86 ) , or placebo ( n = 377 ) [ corrected ] for 8 weeks . Of 833 enrolled patients , 454 discontinued  ( olanzapine , 191/370 [ 51.6 % ] [corrected]OFC , 31/86 [ 36.0 % ] ; and placebo , 232/377 [ 61.6 % ] ) [ corrected ] Compared with placebo , olanzapine-treated patients exhibited greater improvements on SF-36 mental component summary ( MCS ) score ( P=0.002 ) and 3 of 8 SF-36 dimension scores ( mental health [ P=0.015 ] , role-emotional [ P=0.046 ] , and social functioning [ P=0.006 ) . OFC-treated patients exhibited greater improvements on MCS score ( P<0.001 ) vs both placebo and olanzapine ) , 5 SF-36 dimension scores ( general health perception ( P<0.001 ) vs placebo ; ( P<0.001 ) vs olanzapinel , mental health [ P=0.001 ] vs both placebo and olanzapine ] , role-emotional [ P<0.001 ] vs placebo ; [ P=0.007 ] vs olanzapine ] , social functioning [ P=0.001 ] vs placebo ; [ P=0.032 ] vs olanzapine ] , and vitality [ P=0.002 ] vs placebo ; [ P=0.011 ] vs olanzapine ] ) , and QLDS total score ( P<0.001 ] vs both placebo and olanzapine ) . Changes in SF-36 scores of mental health , social functioning , role-emotional , and vitality were highly correlated to changes in the QLDS total score ( all p < -0.5 ) . CONCLUSIONS Based on these analyses , patients with bipolar depression receiving olanzapine or OFC for 8 weeks had greater improvement in HRQOL than those receiving placebo . OFC treatment was associated with greater improvement in HRQOL than olanzapine alone . The correlation results support the construct validity of the QLDS
The EQ-5D and SF-36 achieved mixed results in the quantitative testing against psychometric criteria .
The qualitative analysis suggests this is because they provide a very limited coverage of themes identified by people with mental health problems .
BACKGROUND Generic preference-based measures of health like the EQ-5D and SF-6D ( ® ) are increasingly being used in economic evaluation and outcome assessment .
However , there are concerns as to whether or not these generic measures are appropriate for use in people with mental health problems .
OBJECTIVES The EQ-5D and SF-36 ( ® ) ( including its derivatives the SF-12 ( ® ) and SF-6D ) were assessed using the psychometric criteria of validity and responsiveness using quantitative and qualitative methods .
Another aim was to estimate mapping functions between the EQ-5D and SF-6D and condition-specific measures , where appropriate .