A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .
Effects of modafinil in children with attention-deficit/hyperactivity disorder: an open-label study.
OBJECTIVE To examine the effect of once-daily dosing of modafinil , a stimulant that has a long duration of action , on clinical features of attention-deficit/hyperactivity disorder ( ADHD ) in children . METHOD An open-label design was used to compare the Conners Parent and Teacher Rating Scale-Revised ( L ) ( CPRS , CTRS ) , the ADHD Rating Scale-IV , and the Test of Variables of Attention ( TOVA ) , without and with medication , in children with ADHD . Eleven children with ADHD , ranging in age from 5 to 15 years , took modafinil for an average of 4.6 weeks . RESULTS Average TOVA ADHD scores improved by 2.43 SD ( p = .0009 ) . CTRS and CPRS ADHD index T scores improved by an average of 14.1 ( p = .0009 ) and 17.7 points ( p = .001 ) , respectively . The mean ADHD Rating Scale-IV scores improved from the 88th percentile to the 75th percentile ( p = .047 ) . One subject withdrew from the study because of an adverse event that was resolved completely with medication withdrawal . Other side effects were mild and responded to dose adjustment . No subjects required more than one dose per day . CONCLUSIONS Modafinil may be a useful once-daily treatment for children with ADHD . Further study using a double-blind , placebo-controlled design is needed
A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .