Insulin mediated inhibition of lipolysis was decreased in patients , reflected by increased non-esterified fatty acid levels .
Insulin resistance is a prominent feature of patients with type 1 diabetes mellitus and involves hepatic , peripheral and adipose tissues
OBJECTIVE The aim of this study was to perform a systematic review and meta- analysis on insulin resistance in adult patients with type 1 diabetes mellitus compared to healthy controls , assessed by hyperinsulinemic euglycemic clamp studies .
Natural course of insulin resistance in type I diabetes.
To examine the natural course of insulin action in Type I diabetes , we followed 15 patients prospect ively for one year after the diagnosis of diabetes and also performed a cross-sectional study of 53 additional patients who had had diabetes for 2 to 32 years . Two weeks after diagnosis , the rate of glucose uptake during hyperinsulinemia , a measure of insulin action , was 32 percent lower in the patients with diabetes than in 30 matched normal subjects ( P less than 0.01 ) , but it rose to normal during the subsequent three months . At three months after diagnosis , 9 of 21 patients ( 43 percent ) were in clinical remission and did not require insulin therapy . In these patients , insulin action was 40 percent greater ( P less than 0.002 ) than in the patients who continued to need insulin treatment . Fasting plasma C-peptide levels were slightly but not significantly higher in the patients who had a remission than in the other patients . In patients who had had diabetes for one year or more , insulin action was also reduced by an average of 40 percent ( although there was considerable variation between patients ) , and it was inversely related to glycemic control and relative body weight . Thus , in patients with newly diagnosed Type I diabetes , a transient normalization of insulin action may occur after an initial reduction , along with a partial recovery of endogenous insulin secretion , and these events may contribute to the development of a clinical remission ( " honeymoon " period ) . A majority of patients with diabetes of long duration are characterized by varying degrees of insulin resistance
Insulin mediated inhibition of lipolysis was decreased in patients , reflected by increased non-esterified fatty acid levels .
Insulin resistance is a prominent feature of patients with type 1 diabetes mellitus and involves hepatic , peripheral and adipose tissues
OBJECTIVE The aim of this study was to perform a systematic review and meta- analysis on insulin resistance in adult patients with type 1 diabetes mellitus compared to healthy controls , assessed by hyperinsulinemic euglycemic clamp studies .