Effects of antihypertensive drugs on SBP variability are dose-dependent and persist when used in combinations .
Use of a high dose of a calcium channel blocker alone or in combination with other agents is therefore likely to be particularly effective in prevention of stroke
BACKGROUND AND PURPOSE Recent studies have shown that visit-to-visit blood pressure variability is a powerful risk factor for stroke , is reduced by calcium channel blockers and diuretics , and increased by β-blockers .
However , it is unknown whether these effects are dose-dependent and persist in combination with other drugs .
Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension
This study was conducted to determine the effects of a tablet combining losartan/hydrochlorothiazide ( L/HCTZ ) in comparison with losartan alone in Japanese diabetic patients with hypertension . Thirty consecutive Japanese diabetic patients with hypertension were r and omly assigned to group A , receiving losartan alone for the first 3 months , then L/HCTZ for the next 3 months , or group B , receiving L/HCTZ for the first 3 months , then losartan alone for the next 3 months . Clinical and biological parameters were obtained before , and 3 and 6 months after the start of this study . The decreases in systolic and diastolic blood pressure ( BP ) during treatment with L/HCTZ were significantly greater than in treatment with losartan alone . Both treatments significantly and similarly decreased urinary albumin excretion , the cardio-ankle vascular index ( CAVI ) and augmentation index ( AI ) . There was no significant difference in metabolic change during both the mono- and combination pharmacotherapies . The tablet combining L/HCTZ significantly reduced systolic and diastolic BP compared with the losartan monotherapy , and offered benefits similar to losartan monotherapy for albuminuria , arterial stiffness assessed by the CAVI and AI , and metabolic effects . Thus , the L/HCTZ tablet could be a useful drug for Japanese diabetic patients with hypertension
Effects of antihypertensive drugs on SBP variability are dose-dependent and persist when used in combinations .
Use of a high dose of a calcium channel blocker alone or in combination with other agents is therefore likely to be particularly effective in prevention of stroke
BACKGROUND AND PURPOSE Recent studies have shown that visit-to-visit blood pressure variability is a powerful risk factor for stroke , is reduced by calcium channel blockers and diuretics , and increased by β-blockers .
However , it is unknown whether these effects are dose-dependent and persist in combination with other drugs .