Results show that various classes of antidepressants exert improving effects on cognitive function across several cognitive domains .
Specifically , studies suggest that SSRIs , the SSRE tianeptine , the SNRI duloxetine , vortioxetine and other antidepressants such as bupropion and moclobemide may exert certain improving effects on cognitive function in depression , such as in learning and memory and executive function .
The few non-pharmacological studies conducted employing cognitive orientated treatments and cognitive remediation therapy show promising results for the improvement of cognitive impairment in depression .
Cognitive dysfunction is of clinical significance and exerts longst and ing implication on patients ׳ function .
Pharmacological and non-pharmacological treatments of cognitive dysfunction are emerging .
This review evaluates pharmacological and non-pharmacological treatments of cognitive impairment primarily in the domains of memory , attention , processing speed and executive function in clinical depression .
Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression.
BACKGROUND Tricyclic antidepressants and serotonin reuptake inhibitors are considered to be equally effective , but differences may have been obscured by internally inconsistent measurement scales and inefficient statistical analyses . AIMS To test the hypothesis that escitalopram and nortriptyline differ in their effects on observed mood , cognitive and neurovegetative symptoms of depression . METHOD In a multicentre part-r and omised open-label design ( the Genome Based Therapeutic Drugs for Depression ( GENDEP ) study ) 811 adults with moderate to severe unipolar depression were allocated to flexible dosage escitalopram or nortriptyline for 12 weeks . The weekly Montgomery-Asberg Depression Rating Scale , Hamilton Rating Scale for Depression , and Beck Depression Inventory were scored both conventionally and in a more novel way according to dimensions of observed mood , cognitive symptoms and neurovegetative symptoms . RESULTS Mixed-effect linear regression showed no difference between escitalopram and nortriptyline on the three original scales , but symptom dimensions revealed drug-specific advantages . Observed mood and cognitive symptoms improved more with escitalopram than with nortriptyline .  Neurovegetative symptoms improved more with nortriptyline than with escitalopram . CONCLUSIONS The three symptom dimensions provided sensitive descriptors of differential antidepressant response and enabled identification of drug-specific effects
Results show that various classes of antidepressants exert improving effects on cognitive function across several cognitive domains .
Specifically , studies suggest that SSRIs , the SSRE tianeptine , the SNRI duloxetine , vortioxetine and other antidepressants such as bupropion and moclobemide may exert certain improving effects on cognitive function in depression , such as in learning and memory and executive function .
The few non-pharmacological studies conducted employing cognitive orientated treatments and cognitive remediation therapy show promising results for the improvement of cognitive impairment in depression .
Cognitive dysfunction is of clinical significance and exerts longst and ing implication on patients ׳ function .
Pharmacological and non-pharmacological treatments of cognitive dysfunction are emerging .
This review evaluates pharmacological and non-pharmacological treatments of cognitive impairment primarily in the domains of memory , attention , processing speed and executive function in clinical depression .