REVIEW ER 'S CONCLUSIONS We found no significant evidence to support the use of clotiapine rather than other ' st and ard ' or ' non-st and ard ' treatments for the management of  acute psychotic illness .
BACKGROUND Acute psychotic illness , especially when associated with agitated or violent behaviour , requires urgent pharmacological tranquillisation or sedation .
Clotiapine , a dibenzothiazepine neuroleptic , is being used for this purpose in several countries .
OBJECTIVES To estimate the effects of clotiapine when compared to other ' st and ard ' or ' non-st and ard ' treatments of acute psychotic illness in controlling disturbed behaviour and reducing psychotic symptoms .
Specific major mental disorders and criminality: a 26-year prospective study of the 1966 northern Finland birth cohort.
OBJECTIVE The purpose of the study was to examine the quantitative risk of criminal behavior associated with specific mental disorders . METHOD An unselected 1966 birth cohort ( N = 12,058 ) in Northern Finl and was prospect ively studied until the end of 1992 . The investigation started during the mothers ' pregnancy , and the data on the subjects ' family characteristics , mental and physical development , living habits , psychiatric morbidity , and criminal records were gathered at various times . RESULTS The prevalence of offenses was the highest among males with alcohol-induced psychoses and male schizophrenic subjects with coexisting alcohol abuse , and more than half of the schizophrenic offenders also had problems with alcohol . Eleven ( 7 % ) of the 165 subjects who committed violent crimes were diagnosed as psychotic . Male schizophrenic subjects had a moderately high risk for violent offenses , but the risk for other types of crimes was not elevated significantly . Odds ratios for criminal behavior were adjusted according to the socioeconomic status of the childhood family and were the same as or slightly lower than the crude odds ratios for all disorders except schizophrenia and mood disorders with psychotic features . CONCLUSIONS The results indicate that the risk of criminal behavior was significantly higher among subjects with psychotic disorders , even though the socioeconomic status of the childhood family was controlled . The higher risk for violent behavior was associated especially with alcohol-induced psychoses and with schizophrenia with coexisting substances abuse . The results suggest that schizophrenia without substance abuse may also be associated with a higher risk of offenses , but this finding is tentative and requires further investigation
REVIEW ER 'S CONCLUSIONS We found no significant evidence to support the use of clotiapine rather than other ' st and ard ' or ' non-st and ard ' treatments for the management of  acute psychotic illness .
BACKGROUND Acute psychotic illness , especially when associated with agitated or violent behaviour , requires urgent pharmacological tranquillisation or sedation .
Clotiapine , a dibenzothiazepine neuroleptic , is being used for this purpose in several countries .
OBJECTIVES To estimate the effects of clotiapine when compared to other ' st and ard ' or ' non-st and ard ' treatments of acute psychotic illness in controlling disturbed behaviour and reducing psychotic symptoms .