The conversion of dialysis patients to a vitamin E-coated dialyser is associated with an improvement in circulating biomarkers of lipid peroxidation , which is of potential clinical benefit
BACKGROUND Oxidative stress is prevalent in dialysis patients and has been implicated in the pathogenesis of cardiovascular disease and anaemia .
We conducted a systematic review and meta- analysis to examine the effect of Excebrane , a vitamin E-coated cellulose-based dialyser , on circulating biomarkers of lipid peroxidation , as surrogate markers of oxidative stress .
Vitamin E attenuates oxidative stress induced by intravenous iron in patients on hemodialysis.
Intravenous iron application to anemic patients on hemodialysis leads to an " oversaturation " of transferrin . As a result , non-transferrin-bound , redox-active iron might induce lipid peroxidation . To test the hypothesis that vitamin E attenuates lipid peroxidation in patients receiving 100 mg of iron(III ) hydroxide sucrose complex intravenously during a hemodialysis session , 22 patients were investigated in a r and omized cross-over design , either with or without a single oral dose of 1200 IU of all-rac-alpha-tocopheryl acetate taken 6 h before the hemodialysis session . Blood was drawn before and 30 , 60 , 90 , 135 , and 180 min after the start of the iron infusion , and areas under the curve ( AUC0 - 180 min ) of ratios of plasma malondialdehyde ( MDA ) to cholesterol and plasma total peroxides to cholesterol ( two markers of lipid peroxidation ) were determined as the outcome variables . At baseline of the session without vitamin E supplementation , plasma alpha-tocopherol concentrations ( 27.6 + /- 1.8 micromol/L ) and ratios of alpha-tocopherol to cholesterol ( 5.88 + /- 1.09 mmol/mol ) were normal , plasma MDA concentrations were above normal ( 1.20 + /- 0.28 micromol/ L ) , and bleomycin-detectable iron ( BDI ) , indicating the presence of redox-active iron , was not detectable . Upon iron infusion , BDI and MDA concentrations increased significantly ( P < 0.001 ) . BDI concentrations explained the increase over baseline in MDA concentrations ( MDA = 1.29 + /- 0.075 x BDI ) . Vitamin E supplementation , leading to a 68 % increase in plasma alpha-tocopherol concentrations , significantly reduced the AUC0 - 180 min of MDA to cholesterol ( P = 0.004 ) and peroxides to cholesterol ( P = 0.002 ) . These data demonstrate that a single oral dose of vitamin E attenuates lipid peroxidation in patients on hemodialysis receiving intravenous iron .  Given that intravenous iron is applied repeatedly to patients on hemodialysis , this therapeutic approach may protect against oxidative stress-related degenerative disease in the long term
The conversion of dialysis patients to a vitamin E-coated dialyser is associated with an improvement in circulating biomarkers of lipid peroxidation , which is of potential clinical benefit
BACKGROUND Oxidative stress is prevalent in dialysis patients and has been implicated in the pathogenesis of cardiovascular disease and anaemia .
We conducted a systematic review and meta- analysis to examine the effect of Excebrane , a vitamin E-coated cellulose-based dialyser , on circulating biomarkers of lipid peroxidation , as surrogate markers of oxidative stress .