Small to moderate effect sizes were observed regardless of whether the intervention included exercise .
OBJECTIVE To evaluate studies that used arthritis self-management education alone or with exercise to improve Arthritis Self-Efficacy Scale scores of patients with knee osteoarthritis .
BACKGROUND Increasing self-efficacy may improve patient knee osteoarthritis symptom management and function .
Serum levels of Cartilage Oligomeric Matrix Protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis
Background COMP ( Cartilage oligomeric matrix protein ) is a matrix protein , which is currently studied as a potential serum marker for cartilage processes in osteoarthritis ( OA ) . The influence of physical exercise on serum COMP is not fully eluci date d . The objective of the present study was to monitor serum levels of COMP during a r and omised controlled trial of physical exercise vs. st and ardised rest in individuals with symptomatic and radiographic knee OA . Methods Blood sample s were collected from 58 individuals at predefined time points before and after exercise or rest , one training group and one control group . The physical exercise consisted of a one-hour supervised session twice a week and daily home exercises . In a second supplementary study 7 individuals were subjected to the same exercise program and sampling of blood was performed at fixed intervals before , immediately after , 30 and 60 minutes after the exercise session and then with 60 minutes interval for another five hours after exercise to monitor the short-term changes of serum COMP . COMP was quantified with a s and wich-ELISA ( AnaMar Medical , Lund , Sweden ) . Results Before exercise or rest no significant differences in COMP levels were seen between the groups . After 60 minutes exercise serum COMP levels increased ( p < 0.001 ) . After 60 minutes of rest the serum levels decreased ( p = 0.003 ) . Median serum COMP values in sample s obtained prior to exercise or rest at baseline and after 24 weeks did not change between start and end of the study . In the second study serum COMP was increased immediately after exercise ( p = 0.018 ) and had decreased to baseline levels after 30 minutes . ConclusionS erum COMP levels increased during exercise in individuals with knee OA , whereas levels decreased during rest . The increased serum COMP levels were normalized 30 minutes after exercise session , therefore we suggest that sample s of blood for analysis of serum COMP should be drawn after at least 30 minutes rest in a seated position . No increase was seen after a six-week exercise program indicating that any effect of individualized supervised exercise on cartilage turnover is transient
Small to moderate effect sizes were observed regardless of whether the intervention included exercise .
OBJECTIVE To evaluate studies that used arthritis self-management education alone or with exercise to improve Arthritis Self-Efficacy Scale scores of patients with knee osteoarthritis .
BACKGROUND Increasing self-efficacy may improve patient knee osteoarthritis symptom management and function .