RESULTS Meta- analysis suggested that statin therapy is associated with a significant elevation of PON1 paraoxonase and arylesterase activities , but not PON1 protein concentration .
The PON1-enhancing effects of statins were robust in the sensitivity analyses and were independent of statin dose , treatment duration and changes in plasma low-density lipoprotein cholesterol concentration .
CONCLUSION The increase of paraoxonase and arylesterase activities with statins is a pleiotropic lipid-independent clinical benefit that may partly explain the putative effects of statins in preventing cardiovascular outcomes
BACKGROUND Decreased activity of the enzyme paraoxonase-1 ( PON1 ) has been demonstrated in cardiovascular diseases .
Statins , the forefront of pharmacotherapy for dyslipidemia , have been shown to enhance PON1 activity but clinical findings have not been conclusive .
OBJECTIVE To systematic ally review the clinical findings on the impact of statin therapy on PON1 status ( protein concentrations and activities of paraoxonase and arylesterase ) and calculate an effect size for the mentioned effects through meta- analysis of available data .
Simvastatin treatment prevents oxidative damage to DNA in whole blood leukocytes of dyslipidemic type 2 diabetic patients
Type 2 diabetes ( T2D ) is associated with increased oxidative stress as indicated by elevated levels of lipid peroxidation and protein oxidation products . Since reactive oxygen species ( ROS ) can cause damage to biological macromolecules including DNA , this study investigated oxidative damage to DNA using the alkaline ( pH > 13 ) comet assay in peripheral whole blood leukocytes sample d from 15 dyslipidemic T2D patients treated with simvastatin ( 20 mg/day ) , 15 dyslipidemic T2D patients not treated with simvastatin , 20 non‐dyslipidemic T2D patients , and 20 healthy individuals ( controls ) . Our results showed a greater DNA migration in terms of damage index ( DI ) ( p < 0.01 ) in the dyslipidemic T2D patients not treated with statin ( DI = 67.70 ± 10.89 ) when compared to the dyslipidemic T2D patients under statin treatment ( DI = 47.56 ± 7.02 ) , non‐dyslipidemic T2D patients ( DI = 52.25 ± 9.14 ) , and controls ( DI = 13.20 ± 6.40 ) . Plasma malondialdehyde ( MDA ) and C‐reactive protein ( CRP ) levels were also increased and total antioxidant reactivity ( TAR ) and paraoxonase activity ( PON1 ) decreased in non‐dyslipidemic T2D patients and dyslipidemic T2D non‐treated with simvastatin . We also found that DI was inversely correlated with TAR ( r = −0.61 , p < 0.05 ) and PON1 ( r = −0.67 , p < 0.01 ) . In addition , there was a significant positive correlation between DI and CRP ( r = 0.80 , p < 0.01 ) . Our results therefore indicate that simvastatin treatment plays a protective role on oxidative damage to DNA in dyslipidemic T2D patients probably reflecting a general decrease in oxidative stress in these patients . Copyright © 2010 John Wiley & Sons ,
RESULTS Meta- analysis suggested that statin therapy is associated with a significant elevation of PON1 paraoxonase and arylesterase activities , but not PON1 protein concentration .
The PON1-enhancing effects of statins were robust in the sensitivity analyses and were independent of statin dose , treatment duration and changes in plasma low-density lipoprotein cholesterol concentration .
CONCLUSION The increase of paraoxonase and arylesterase activities with statins is a pleiotropic lipid-independent clinical benefit that may partly explain the putative effects of statins in preventing cardiovascular outcomes
BACKGROUND Decreased activity of the enzyme paraoxonase-1 ( PON1 ) has been demonstrated in cardiovascular diseases .
Statins , the forefront of pharmacotherapy for dyslipidemia , have been shown to enhance PON1 activity but clinical findings have not been conclusive .
OBJECTIVE To systematic ally review the clinical findings on the impact of statin therapy on PON1 status ( protein concentrations and activities of paraoxonase and arylesterase ) and calculate an effect size for the mentioned effects through meta- analysis of available data .