Pain intensity of chronic non-cancer patients was reduced by cannabinoids consumption , but effect sizes were small .
Efficacy for neuropathic and non-neuropathic pain was similar
There is growing interest in using cannabinoids for chronic pain .
We performed a systematic review and meta- analysis of r and omized controlled trials to evaluate the analgesic efficacy and adverse effects of cannabinoids for chronic non-cancer pain .
Single dose delta-9-tetrahydrocannabinol in chronic pancreatitis patients: analgesic efficacy, pharmacokinetics and tolerability.
AIM We aim ed to assess the analgesic efficacy , pharmacokinetics , tolerability and safety of a single dose of Δ9-THC in patients with chronic abdominal pain result ing from chronic pancreatitis ( CP ) . METHODS This was a r and omized , single dose , double-blinded , placebo-controlled , two way crossover study in patients suffering from abdominal pain as result of CP ( n = 24 ) , post hoc subdivided into opioid and non-opioid users .  Δ9-THC ( 8 mg ) or active placebo ( 5 mg/10 mg diazepam ) was administered orally in a double dummy design . RESULTS No treatment effect was shown for delta VAS pain scores after Δ9-THC compared with diazepam . Δ9-THC was well absorbed with a mean tmax of 123 min . No significant differences were found between Δ9-THC vs. diazepam for alertness , mood , calmness or balance . Feeling anxious and heart rate were significantly increased after Δ9-THC compared with diazepam . The most frequently reported adverse events ( AEs ) after Δ9-THC administration were somnolence , dry mouth , dizziness and euphoric mood . CONCLUSIONS A single dose of Δ9-THC was not efficacious in reducing chronic pain result ing from CP , but was well tolerated with only mild or moderate AEs . The PK results in CP patients showed delayed absorption and an increased variability compared with healthy volunteers
Pain intensity of chronic non-cancer patients was reduced by cannabinoids consumption , but effect sizes were small .
Efficacy for neuropathic and non-neuropathic pain was similar
There is growing interest in using cannabinoids for chronic pain .
We performed a systematic review and meta- analysis of r and omized controlled trials to evaluate the analgesic efficacy and adverse effects of cannabinoids for chronic non-cancer pain .