SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .
Clinical Features and Efficacy of Escitalopram Treatment for Geriatric Depression
This study investigated the psychological characteristics and clinical features of 55 patients with geriatric depression , and evaluated the efficacy and safety of escitalopram in the treatment of geriatric depression , in a r and omized controlled trial . Fifty-five patients with geriatric depression were r and omly assigned to receive 8 weeks of escitalopram 10 mg , daily , orally ( n = 29 ) or placebo ( n = 26 ) . At baseline , these patients had significantly higher neuroticism and psychoticism scores on the Eysenck Personality Question naire - Adult scale than Chinese population norms . General Severity Index scores and the mean values of the nine subscales of the Symptom Checklist-90- Revised scale were also significantly higher in these patients than in Chinese population norms . The response rate to escitalopram after 8 weeks ' treatment was 74.1 % ( 20/27 patients ) . Adverse reactions included nausea , dry mouth and dizziness . In conclusion , depressed geriatric patients were found to have abnormal personality traits , and escitalopram was efficacious and had a good safety profile in the treatment of geriatric depression
SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .