Not all the studies that investigated all the conditions in the triad , but the authors concluded that it seemed that athletes were in more severe stage of this disorder .
Effects of an oral contraceptive (norgestimate/ethinyl estradiol) on bone mineral density in adolescent females with anorexia nervosa: a double-blind, placebo-controlled study.
PURPOSE To evaluate the effect of an oral contraceptive ( OC ) on bone mineral density ( BMD ) in adolescent females with anorexia nervosa ( AN ) or eating disorder not otherwise specified ( EDNOS ) . METHODS Females 11 - 17 years of age with AN or EDNOS entered the study . Subjects were r and omized equally to treatment with a triphasic OC containing norgestimate ( NGM ) 180 - 250 microg and ethinyl estradiol ( EE ) 35 microg or placebo for 13 28-day cycles . Dual energy x-ray absorptiometry scans  ( DXA ) of the lumbosacral spine ( LS ) and hip were obtained at baseline and after 6 and 13 cycles . RESULTS Demographic characteristics of the 112 subjects ( NGM/EE 53 ; Placebo 59 ) who received study drug and had at least one on-treatment DXA were similar between groups for age ( mean : 15 years in each group ) and body mass index ( mean : NGM/EE 17.9 kg/m2 ; Placebo 17.6 kg/m2 ) . At the end of Cycle 6 , there was a significant increase in the mean LS BMD in the NGM/EE group compared with placebo ( .020 g/cm2 vs. .008 g/cm2 ; p = .021 ) ; however , at the end of Cycle 13 the mean increase in LS BMD in the NGM/EE group compared with placebo was no longer significant ( .026 g/cm2 vs. .019 g/cm2 , p = .244 ) . There was no significant difference in change in hip BMD between groups . The incidence of adverse events was similar between groups . CONCLUSIONS In a group of adolescent females with AN or EDNOS , treatment with a triphasic OC for 13 cycles did not have a statistically significant effect on LS or hip BMD
Not all the studies that investigated all the conditions in the triad , but the authors concluded that it seemed that athletes were in more severe stage of this disorder .