Conclusion Applying the CHERG rules , we recommend a 73 % reduction in anemia at term with daily iron ( alone ) supplementation or iron/folate ( combined ) vs. no intervention or placebo ; for inclusion in the LiST model .
Introduction Iron deficiency is the most prevalent nutrient deficiency in the world , particularly during pregnancy .
According to the literature , anemia , particularly severe anemia , is associated with increased risk of maternal mortality .
It also puts mothers at risk of multiple perinatal complications .
Numerous studies in the past have evaluated the impact of supplementation with iron and iron-folate but data regarding the efficacy and quality of evidence of these interventions are lacking .
This article aims to address the impact of iron with and without folate supplementation on maternal anemia and provides outcome specific quality according to the Child Health Epidemiology Reference Group ( CHERG ) guidelines .
[Therapy and iron supplements with ferritin iron during pregnancy. Randomized prospective study of 458 cases].
A r and omized polycentric study was programmed to establish the effects of daily administration of ferritin iron from early pregnancy to puerperium . 254 women with normal iron balance at the beginning of their pregnancy were r and omized receiving no supplements or 40 mg iron daily . At the end of pregnancy iron balance was still normal only in one third of the pregnant women of the first group versus two third of the second group . 204 women who were iron-deficient received daily 40 or 120 mg of iron ; in this group anemia developed less frequently ( 13 % versus 29 % ) and iron balance normalized in one subject on four ; the great majority of these women remained iron-deficient . Unwanted effects of minimal or mild relevance , and almost always sporadic were observed in 6.5 % of cases and with the reduction or withdraw of the treatment in only 1.4 % of cases . These results showed that daily administration of ferritin iron during pregnancy is effective and well tolerated ; furthermore they suggest that the treatment must be done with at least 60 mg daily in women with normal iron balance and protracted also after the puerperium in iron deficient subjects
Conclusion Applying the CHERG rules , we recommend a 73 % reduction in anemia at term with daily iron ( alone ) supplementation or iron/folate ( combined ) vs. no intervention or placebo ; for inclusion in the LiST model .
Introduction Iron deficiency is the most prevalent nutrient deficiency in the world , particularly during pregnancy .
According to the literature , anemia , particularly severe anemia , is associated with increased risk of maternal mortality .
It also puts mothers at risk of multiple perinatal complications .
Numerous studies in the past have evaluated the impact of supplementation with iron and iron-folate but data regarding the efficacy and quality of evidence of these interventions are lacking .
This article aims to address the impact of iron with and without folate supplementation on maternal anemia and provides outcome specific quality according to the Child Health Epidemiology Reference Group ( CHERG ) guidelines .