During subgroup analysis , a more beneficial effect of magnesium supplementation was observed in diabetic subjects with hypomagnesaemia .
CONCLUSIONS Magnesium supplementation can produce a favourable effect on FPG , HDL , LDL , TG and SBP .
BACKGROUND Cardiovascular disorders remain the leading cause of death in type 2 diabetic patients .
In the present study , a systematic review and a meta- analysis of r and omised controlled trials ( RCTs ) were conducted aim ing to evaluate the effect of magnesium supplementation on  type 2 diabetes ( T2D ) associated cardiovascular risk factors in both diabetic and nondiabetic individuals .
Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg-depleted rats using a stable isotope approach.
Literature data on the bioavailability of various Mg forms provide scarce information on the best Mg salt to be used in animal and human supplementation . This study aim ed to investigate the bioavailability of different forms of Mg in rats using Mg stable isotopes . Eighty male Wistar rats aged 6 weeks were fed a semi-purified Mg-depleted diet for three weeks . The rats were then r and omised into ten groups and received , for two more weeks , the same diet repleted with Mg ( 550 mg Mg/kg ) as : oxide , chloride , sulphate , carbonate , acetate , pidolate , citrate , gluconate , lactate or aspartate . After 10 days of Mg-repleted diet , the rats received orally 1.8 mg of an enriched 26Mg . Faeces and urine were then collected for 4 consecutive days . Isotope ratios in faeces and urine were determined . The Mg absorption values obtained varied from 50 % to 67 % . Organic Mg salts were slightly more available than inorganic Mg salts . Mg gluconate exhibited the highest Mg bioavailability of the ten Mg salts studied . Urinary 26Mg excretion varied from 0.20 mg to 0.33 mg , and feeding with the organic pidolate , citrate , gluconate and aspartate salts result ed in higher urinary 26Mg excretion than with inorganic salts . Ultimately , 26Mg retention was higher in the rats receiving the organic salts such as gluconate , lactate and aspartate than in those receiving the inorganic salts . Taken together , these results indicate that 26Mg is sufficiently bioavailable from the ten different Mg salts studied in the present experiment , although Mg gluconate exhibited the highest bioavailability under these experimental conditions
During subgroup analysis , a more beneficial effect of magnesium supplementation was observed in diabetic subjects with hypomagnesaemia .
CONCLUSIONS Magnesium supplementation can produce a favourable effect on FPG , HDL , LDL , TG and SBP .
BACKGROUND Cardiovascular disorders remain the leading cause of death in type 2 diabetic patients .
In the present study , a systematic review and a meta- analysis of r and omised controlled trials ( RCTs ) were conducted aim ing to evaluate the effect of magnesium supplementation on  type 2 diabetes ( T2D ) associated cardiovascular risk factors in both diabetic and nondiabetic individuals .