The only eligible r and omised clinical trial did not demonstrate any consistent effects of NIRS plus a guideline on the assessed clinical outcomes .
The trial was , however , only powered to detect difference in cerebral oxygenation , not morbidities or mortality .
BACKGROUND Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants .
Cerebral near-infrared spectroscopy ( NIRS ) enables continuous estimation of cerebral oxygenation .
This diagnostic method coupled with appropriate interventions if NIRS is out of normal range ( that is cerebral oxygenation within the 55 % to 85 % range ) may offer benefits without causing more harms .
Therefore , NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of r and omised clinical trials and quasi-r and omised studies .
OBJECTIVES To evaluate the benefits and harms of interventions that attempt to alter cerebral oxygenation guided by cerebral NIRS monitoring in order to prevent cerebral injury , improve neurological outcome , and increase survival in preterm infants born more than 8 weeks preterm .
Measurement of cerebral oxygenation state in anaesthetized children using the INVOS 5100 cerebral oximeter.
BACKGROUND Near-infrared spectroscopy is a developing technique for monitoring cerebral oxygenation during anaesthesia . The aim of this study was to evaluate absolute values of cerebral oxygenation during stable anaesthesia conditions in otherwise healthy children using the recently introduced INVOS 5100 cerebral oximeter with a paediatric and adult sensor and to compare them with values obtained from the NIRO 300 oximeter . METHODS Thirty paediatric surgical patients ( aged 0.23 - 15.97 years ) were studied during general anaesthesia with tracheal intubation and controlled ventilation .  Comparative measurements of cerebral oxygenation were performed on the forehead with two probes within 10 min under stable cardiorespiratory and anaesthesia conditions . Cerebral oxygenation values ( rSO2 ) obtained from the paediatric and adult INVOS 5100 sensors were compared with the tissue oxygenation index ( TOI ) obtained from the NIRO 300 cerebral oximeter using 4- and 5-cm emitter-detector separation . RESULTS Cerebral rSO2 values and the TOI values both showed a large range of cerebral oxygenation in the children studied ( rSO2 : 59 - 95 % , TOI : 48 - 85 % ) . Cerebral rSO2 values measured by the INVOS 5100 , particularly with the paediatric sensor , were significantly higher than the TOI values obtained from the NIRO 300 ( P < 0.0001 ) . Agreement between the INVOS and NIRO oximeter was poor . CONCLUSION The large range and the poor agreement of cerebral oxygenation values between the two oximeters makes it difficult to define a normal value . Cerebral oxygenation readings by these monitors , based on one single point measurement during anaesthesia , should be viewed with caution . Actually , there may be little indication for routine use of such monitoring during general anaesthesia
The only eligible r and omised clinical trial did not demonstrate any consistent effects of NIRS plus a guideline on the assessed clinical outcomes .
The trial was , however , only powered to detect difference in cerebral oxygenation , not morbidities or mortality .
BACKGROUND Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants .
Cerebral near-infrared spectroscopy ( NIRS ) enables continuous estimation of cerebral oxygenation .
This diagnostic method coupled with appropriate interventions if NIRS is out of normal range ( that is cerebral oxygenation within the 55 % to 85 % range ) may offer benefits without causing more harms .
Therefore , NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of r and omised clinical trials and quasi-r and omised studies .
OBJECTIVES To evaluate the benefits and harms of interventions that attempt to alter cerebral oxygenation guided by cerebral NIRS monitoring in order to prevent cerebral injury , improve neurological outcome , and increase survival in preterm infants born more than 8 weeks preterm .