RESULTS BZDs are ineffective for PTSD treatment and prevention , and risks associated with their use tend to outweigh potential short-term benefits .
In addition to adverse effects in general population s , BZDs are associated with specific problems in patients with PTSD : worse overall severity , significantly increased risk of developing PTSD with use after recent trauma , worse psychotherapy outcomes , aggression , depression , and substance use .
The results of this systematic review suggest that BZDs should be considered relatively contraindicated for patients with PTSD or recent trauma .
OBJECTIVE Although benzodiazepines ( BZDs ) are commonly used in the treatment of posttraumatic stress disorder ( PTSD ) , no systematic review or meta- analysis has specifically examined this treatment .
The goal of this study was to analyze and summarize evidence concerning the efficacy of BZDs in treating PTSD .
Anti-Intrusion Effect of Lorazepam: An Experimental Study
Objective Easy triggering of trauma-related episodic memory fragments caused by perceptual cues is tied to strong perceptual priming in the implicit memory system . And among benzodiazepines , only lorazepam has been consistently reported to have an atypical suppression effect on perceptual priming processes . The aim of this study was to investigate the effects of single doses of lorazepam , diazepam , and a placebo on intrusive memories after exposure to a distressing videotape and to explore whether the anti-intrusive effect of lorazepam is acquired as a result of the suppression of perceptual but not conceptual priming processes . Methods Under prospect i ve , r and omized , and double-blind conditions , we compared the anti-intrusion effect of a single dose of lorazepam ( n=22 ) with that of diazepam ( n=22 ) and a placebo ( n=21 ) in young healthy Korean college students following exposure to a traumatic videotape . Results We present the first finding for an anti-intrusion effect of lorazepam . One day after the medication , lorazepam , rather than diazepam or the placebo , significantly reduced the extent of intrusion and data -driven processing of the traumatic information . There were no differences among the three conditions in state anxiety , depression , and an arousal scale throughout the experiment . Conclusion Results from this study suggest the possibility of lorazepam as a c and i date anti-intrusion drug , as well as the cautious use of diazepam in the treatment of PTSD patients . The anti-intrusive effect of lorazepam is directly related to its atypical inhibitory effect on implicit perceptual priming processes . The present study provides support for the enhanced perceptual priming hypothesis of PTSD
RESULTS BZDs are ineffective for PTSD treatment and prevention , and risks associated with their use tend to outweigh potential short-term benefits .
In addition to adverse effects in general population s , BZDs are associated with specific problems in patients with PTSD : worse overall severity , significantly increased risk of developing PTSD with use after recent trauma , worse psychotherapy outcomes , aggression , depression , and substance use .
The results of this systematic review suggest that BZDs should be considered relatively contraindicated for patients with PTSD or recent trauma .
OBJECTIVE Although benzodiazepines ( BZDs ) are commonly used in the treatment of posttraumatic stress disorder ( PTSD ) , no systematic review or meta- analysis has specifically examined this treatment .
The goal of this study was to analyze and summarize evidence concerning the efficacy of BZDs in treating PTSD .