Prolonged antioxidant vitamin E and /or C supplementation could be effective to improve endothelial function in non-obese T2DM subjects
Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus ( T2DM ) subjects .
The aim of this study was to systematic ally review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects .
Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus.
BACKGROUND Insulin therapy may influence cardiovascular disease ( CVD ) and lipid metabolism in type 2 diabetes ( T2D ) . Exaggerated postpr and ial lipaemia ( PPL ) is a feature of diabetic dyslipidaemia affecting CVD via enhanced oxidative stress ( OS ) and endothelial dysfunction . We assessed endothelial function and OS during PPL following insulin and vitamin C.  Twenty ( 17 M ) T2D patients were studied ( mean Hba1c 8.4 % ) at baseline , following 6 weeks of insulin lispro ( 0.2 Iu kg-1 ) and vitamin C 1-g  daily . Eight-h  lipid and glucose profiles were measured following a fatty meal .  Endothelial function ( flow-mediated vasodilatation : FMD ) and OS were measured at fasting , 4 h and 8 h. MATERIAL S AND METHODS Glucose , body mass index , and total and LDL cholesterol remained unchanged . FMD improved . Placebo group : fasting , 1.1 + /- 1.2 to 4.2 + /- 1.1 % ( P < 0.001 ) ; 4-h , 0.3 + /- 1.2 to 3.1 + /- 0.9 % ( P < 0.01 ) ; 8-h , 0.7 + /- 1.1 to 3.76 + /- 1.1 % ( P < 0.001 ) . Vitamin C group : fasting , 0.9 + /- 1.1 to 6.1 + /- 1.3 % ( P < 0.001 ) ; 4-h , 0.7 + /- 1.5 to 4.9 + /- 2.1 % ( P < 0.001 ) ; 8-h , 0.8 + /- 0.9 to 5.8 + /- 0.6 % ( P < 0.01 ) . Post-pr and ial lipaemia was attenuated : TG area-under-curve ( mmol L-1 8 h-1 ) , 52.6 + /- 11 to 39.1 + /- 12.5 ( placebo group ) , P < 0.02 ; and 56.9 + /- 8 to 40.1 + /- 10.3 ( vitamin C group ) , P < 0.02 . Oxidative stress was reduced , with greater changes in the vitamin C group . CONCLUSION Insulin may thus exert vascular benefits in T2D , by modifying fasting and postpr and ial lipid metabolism result ing in reduced OS and improved EF . Vitamin C therapy may augment the vascular benefits of insulin in T2D through additional effects on OS and EF
Prolonged antioxidant vitamin E and /or C supplementation could be effective to improve endothelial function in non-obese T2DM subjects
Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus ( T2DM ) subjects .
The aim of this study was to systematic ally review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects .