The medicine use and quality of life were solely improved in the surgical group .
Nutritional deficiencies and anemia were noted more frequently in the RYGB group .
RYGB surgery is superior to medical treatment for short- to medium-term remission of T2DM , improvement of metabolic condition , and cardiovascular risk factors .
Abstract The aim of the study is to compare Roux-en-Y gastric bypass ( RYGB ) surgery versus medical treatment for  type 2 diabetes mellitus ( T2DM ) in obese patients .Bariatric  surgery can achieve remission of T2DM in obese patients .
RYGB surgery has been performed as one of the most common surgical treatment options for obese patients with T2DM , but the efficacy of RYGB surgery comparing with medical treatment alone has not been conclusively determined .
Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
Summary Bariatric surgery is currently the most effective procedure for the treatment of obesity . Given the role of the gut microbiota in regulating host metabolism and adiposity , we investigated the long-term effects of bariatric surgery on the microbiome of patients r and omized to Roux-en-Y gastric bypass or vertical b and ed gastroplasty and matched for weight and fat mass loss . The two surgical procedures induced similar and durable changes on the gut microbiome that were not dependent on body mass index and result ed in altered levels of fecal and circulating metabolites compared with obese controls . By colonizing germ-free mice with stools from the patients , we demonstrated that the surgically altered microbiota promoted reduced fat deposition in recipient mice . These mice also had a lower respiratory quotient , indicating decreased utilization of carbohydrates as fuel . Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery
The medicine use and quality of life were solely improved in the surgical group .
Nutritional deficiencies and anemia were noted more frequently in the RYGB group .
RYGB surgery is superior to medical treatment for short- to medium-term remission of T2DM , improvement of metabolic condition , and cardiovascular risk factors .
Abstract The aim of the study is to compare Roux-en-Y gastric bypass ( RYGB ) surgery versus medical treatment for  type 2 diabetes mellitus ( T2DM ) in obese patients .Bariatric  surgery can achieve remission of T2DM in obese patients .
RYGB surgery has been performed as one of the most common surgical treatment options for obese patients with T2DM , but the efficacy of RYGB surgery comparing with medical treatment alone has not been conclusively determined .