Meta- analysis of RCTs showed that only cyclosporine A provided a simultaneous great effect size of SMD on ICSI , pain , and frequency .
Amitriptyline at different dosages showed a great effect size of SMD on pain and urgency or on ICSI and frequency .
The results from the n RCTs showed that the most frequently adopted treatment is oral pentosan polysulfate and that the use of botulinum A toxin intradetrusorial injections in PBS/IC is increasing .
Limited evidence exists for the few treatments for PBS/IC .
The lack of definitive conclusions is due to the great heterogeneity in methodology , symptoms assessment , duration of treatment , and follow-up in both RCTs and n RCTs
CONTEXT Different types of behavioural , dietary , interventional , pharmacologic , and surgical therapies have been used to treat painful bladder syndrome/interstitial cystitis ( PBS/IC ) .
Because of the paucity of r and omised placebo-controlled studies on different treatments , an evidence -based management approach has not yet been developed .
OBJECTIVE To critically review and synthesize data from a wide range of current therapeutic approaches to PBS/IC , to quantify the effect size from r and omised controlled trials ( RCTs ) , and to reach clinical agreement on the efficacy of treatments for PBS/IC .
Pilot study of sequential oral antibiotics for the treatment of interstitial cystitis.
PURPOSE Interstitial cystitis is a chronic disease of unknown etiology characterized by bladder pain , urgency and frequency . Although a single microbe has not been implicated as a cause of interstitial cystitis , several groups noted various organisms in the urine of some women with interstitial cystitis and some patients reported that antibiotics decrease symptoms . Consequently we performed a prospect i ve , r and omized , double-blinded , placebo controlled pilot study of sequential oral antibiotics . MATERIAL S AND METHODS We r and omized 50 patients with interstitial cystitis to receive 18 weeks of placebo or antibiotics , including rifampin plus a sequence of doxycycline , erythromycin , metronidazole , clindamycin , amoxicillin and ciprofloxacin for 3 weeks each . RESULTS Intent to treat analysis demonstrated that 12 of 25 patients ( 48 % ) in the antibiotic and 6 of 25 ( 24 % ) in the placebo group reported overall improvement ( p = 0.14 ) , while 10 and 5 , respectively , noticed improvement in pain and urgency ( p = 0.22 ) . In the antibiotic group 20 participants ( 80 % ) had adverse effects compared with 10 ( 40 % ) in the placebo group ( p = 0.009 ) . CONCLUSIONS Our findings suggest that these antibiotics alone or in combination may sometimes be associated with decreased symptoms in some patients but they do not represent a major advance in therapy for interstitial cystitis
Meta- analysis of RCTs showed that only cyclosporine A provided a simultaneous great effect size of SMD on ICSI , pain , and frequency .
Amitriptyline at different dosages showed a great effect size of SMD on pain and urgency or on ICSI and frequency .
The results from the n RCTs showed that the most frequently adopted treatment is oral pentosan polysulfate and that the use of botulinum A toxin intradetrusorial injections in PBS/IC is increasing .
Limited evidence exists for the few treatments for PBS/IC .
The lack of definitive conclusions is due to the great heterogeneity in methodology , symptoms assessment , duration of treatment , and follow-up in both RCTs and n RCTs
CONTEXT Different types of behavioural , dietary , interventional , pharmacologic , and surgical therapies have been used to treat painful bladder syndrome/interstitial cystitis ( PBS/IC ) .
Because of the paucity of r and omised placebo-controlled studies on different treatments , an evidence -based management approach has not yet been developed .
OBJECTIVE To critically review and synthesize data from a wide range of current therapeutic approaches to PBS/IC , to quantify the effect size from r and omised controlled trials ( RCTs ) , and to reach clinical agreement on the efficacy of treatments for PBS/IC .