Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Combined therapy with ramipril and simvastatin has beneficial additive effects on tissue factor activity and prothrombin fragment 1+2 in patients with type 2 diabetes.
Tissue factor ( TF ) plays a pivotal role in thrombus formation . Statins and angiotensin converting enzyme inhibitors attenuate expression of TF by distinct mechanism . Therefore , we hypothesized that combined therapy with simvastatin and ramipril may have additive beneficial anti-atherogenic effects to lower TF activity when compared with either drug alone . This was a r and omized , double-blind , placebo-controlled cross-over trial with three treatment arms ( each 2 months ) and two washout periods ( each 2 months ) . Fifty patients with type 2 diabetes were given simvastatin 20 mg and placebo , simvastatin 20 mg and ramipril 10 mg , or ramipril 10 mg and placebo daily during each treatment period . Simvastatin and ramipril monotherapy tended to reduce TF activity ( 0.53 to 0.46 nM , P=0.056 ; 0.54 to 0.50 nM , P=0.167 , respectively ) while combined therapy had a significant effect ( 0.64 to 0.43 nM , P<0.001 ) . All three therapies significantly reduced prothrombin fragment 1 + 2 ( F1 + 2 ) levels from their respective baselines ( P=0.037 , P<0.001 , and P=0.057 , respectively ) . Combined therapy significantly reduced TF activity and F1 + 2 levels to a greater extent than either simvastatin or ramipril alone ( P=0.029 and P=0.040 by ANOVA , respectively ) . Percent changes in TF activity and percent changes in F1 + 2 levels were significantly correlated . All three therapies reduced CD40 lig and levels from their respective baselines ( P=0.098 , P<0.001 , and P=0.002 , respectively ) with no significant differences among these three therapies ( P=0.204 by ANOVA ) . Ramipril combined with simvastatin significantly reduces plasma TF activity and F1 + 2 levels to a greater extent than monotherapy with either drug in patients with type 2 diabetes
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .