In summary , the current meta- analysis demonstrated that melatonin supplementation  significantly decreased SBP and DBP in patients with metabolic disorders .
The current systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to evaluate the potential effect of melatonin supplementation on  blood pressure in patients with metabolic disorders .
Daily Nighttime Melatonin Reduces Blood Pressure in Male Patients With Essential Hypertension
Abstract — Patients with essential hypertension have disturbed autonomic cardiovascular regulation and circadian pacemaker function . Recently , the biological clock was shown to be involved in autonomic cardiovascular regulation . Our objective was to determine whether enhancement of the functioning of the biological clock by repeated nighttime melatonin intake might reduce ambulatory blood pressure in patients with essential hypertension . We conducted a r and omized , double-blind , placebo-controlled , crossover trial in 16 men with untreated essential hypertension to investigate the influence of acute ( single ) and repeated ( daily for 3 weeks ) oral melatonin ( 2.5 mg ) intake 1 hour before sleep on 24-hour ambulatory blood pressure and actigraphic estimates of sleep quality . Repeated melatonin intake reduced systolic and diastolic blood pressure during sleep by 6 and 4 mm Hg , respectively . The treatment did not affect heart rate . The day – night amplitudes of the rhythms in systolic and diastolic blood pressures were increased by 15 % and 25 % , respectively . A single dose of melatonin had no effect on blood pressure . Repeated ( but not acute ) melatonin also improved sleep . Improvements in blood pressure and sleep were statistically unrelated . In patients with essential hypertension , repeated bedtime melatonin intake significantly reduced nocturnal blood pressure . Future studies in larger patient group should be performed to define the characteristics of the patients who would benefit most from melatonin intake . The present study suggests that support of circadian pacemaker function may provide a new strategy in the treatment of essential hypertension
In summary , the current meta- analysis demonstrated that melatonin supplementation  significantly decreased SBP and DBP in patients with metabolic disorders .
The current systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to evaluate the potential effect of melatonin supplementation on  blood pressure in patients with metabolic disorders .