There is very-low- quality evidence that clonidine has a small effect on oppositional behaviour and conduct problems in youth with ADHD , with and without ODD or CD .
There is moderate- quality evidence that guanfacine has a small-to-moderate effect on oppositional behaviour in youth with ADHD , with and without ODD .
There is high- quality evidence that atomoxetine has a small effect on oppositional behaviour in youth with ADHD , with and without ODD or CD .
Conclusions : Evidence indicates that psychostimulants , alpha-2 agonists , and atomoxetine can be beneficial for disruptive and aggressive behaviours in addition to core ADHD symptoms ; however , psychostimulants generally provide the most benefit
Objective : Children with attention-deficit hyperactivity disorder ( ADHD ) may have oppositional behaviour , conduct problems , and aggression .
These symptoms vary in severity , and may be related to a comorbid diagnosis of oppositional defiant disorder ( ODD ) or conduct disorder ( CD ) .
Critical evaluation of the efficacy of ADHD medications may guide the clinician regarding the usefulness of medications for these symptoms .
Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD.
Stimulant medication and behavioral treatments are evidence -based for children with attention-deficit/hyperactivity disorder , but the combination of the 2 treatments has been understudied . In this investigation , methylpheni date ( MPH ) was crossed with 2 levels of behavior modification ( BMOD ) in a summer treatment program .  Twenty-seven children with attention-deficit/hyperactivity disorder , aged 6 - 12 , participated . Children received placebo and 3 doses of transdermal MPH ( 12.5 cm(2 ) , 25.0 cm(2 ) , and 37.5 cm(2 ) ) . BMOD was implemented on alternating weeks . Both treatments produced large and significant effects . Combined treatment was superior to either treatment alone . The effects of transdermal MPH were comparable to those found in this setting in previous studies with multiple stimulant medications and formulations . Consistent with other research , low doses of MPH -- even lower than in previous studies --yielded enhanced effects in combination with behavior modification
There is very-low- quality evidence that clonidine has a small effect on oppositional behaviour and conduct problems in youth with ADHD , with and without ODD or CD .
There is moderate- quality evidence that guanfacine has a small-to-moderate effect on oppositional behaviour in youth with ADHD , with and without ODD .
There is high- quality evidence that atomoxetine has a small effect on oppositional behaviour in youth with ADHD , with and without ODD or CD .
Conclusions : Evidence indicates that psychostimulants , alpha-2 agonists , and atomoxetine can be beneficial for disruptive and aggressive behaviours in addition to core ADHD symptoms ; however , psychostimulants generally provide the most benefit
Objective : Children with attention-deficit hyperactivity disorder ( ADHD ) may have oppositional behaviour , conduct problems , and aggression .
These symptoms vary in severity , and may be related to a comorbid diagnosis of oppositional defiant disorder ( ODD ) or conduct disorder ( CD ) .
Critical evaluation of the efficacy of ADHD medications may guide the clinician regarding the usefulness of medications for these symptoms .