These findings were robust in sensitivity analyses .
Conclusions This meta- analysis suggests that Mg supplementation significantly reduces serum CRP level .
Introduction The aim of the study was to undertake a systematic review and meta- analysis of prospect i ve studies to determine the effect of magnesium ( Mg ) supplementation on  C-reactive protein ( CRP ) .
Oral magnesium supplementation decreases alanine aminotransferase levels in obese women.
To evaluate the effect of oral supplementation with magnesium chloride on the systemic and hepatic inflammation , 38 non-hypertensive obese women aged 30 to 65 years were allocated into groups with and without hypomagnesemia . Hypomagnesemic women drank 50 mL of 5 % solution of MgCl2 equivalent to 450 mg of elemental magnesium . Low-carbohydrate diets and physical activity were indicated for women in both groups . Chronic diarrhea , alcohol intake , use of diuretics , previous oral magnesium supplementation , hepatic disease , and renal damage were exclusion criteria . Hypomagnesemia is defined by serum magnesium concentrations < or=1.8 mg/dL , hepatic inflammation by serum alanine aminotransferase ( ALT ) levels > or=40 U/L , and systemic inflammation by serum high-sensitivity C reactive protein ( hs-CRP ) concentration > or=3 mg/L. At baseline ( p=0.06 ) and final of follow-up ( p=0.80 ) , there were no significant differences by body mass index between the groups in the study . In the same way , at baseline ALT ( 48.1+/-25.5 and 34.6+/-24.1 U/L , p=0.14 ) and hs-CRP ( 9.4+/-6.0 and 7.9+/-5.9 mg/dL , p=0.47 ) levels were similar in the supplemented and non-supplemented women . In the magnesium group , ALT ( 24.3+/-10.3 and 34.8+/-13.6 U/L , p=0.02 ) levels , but not hs-CRP ( 5.2+/-1.9 and 8.0+/-5.6 mg/L , p=0.08 ) reached significantly lower levels , in the fourth month of treatment , than in women in the control group . The adjusted odds ratios between the improvement in serum magnesium and reduction in ALT and hs-CRP levels were 0.56 ( 95 % CI : 0.3 - 0.9 ) and 0.93 ( 95 % CI : 0.6 - 29.9 ) , respectively . Results of this study show that in hypomagnesemic obese women , oral supplementation with magnesium chloride reduces plasma ALT levels ; hs-CRP levels only show a reduction trend
These findings were robust in sensitivity analyses .
Conclusions This meta- analysis suggests that Mg supplementation significantly reduces serum CRP level .
Introduction The aim of the study was to undertake a systematic review and meta- analysis of prospect i ve studies to determine the effect of magnesium ( Mg ) supplementation on  C-reactive protein ( CRP ) .