This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .
Influence of intraperitoneal anesthesia on pain and the sympathoadrenal response to abdominal surgery
The effects of intraperitoneal administration of bupivacaine on pain and the sympathoadrenal response to surgery were studied in a double‐blind r and omized trial in 19 patients undergoing cholecystectomy .  Bupivacaine ( 2 mg/kg ) was dissolved in 300 ml isotonic saline and administered into the peritoneal cavity 10 min before the operation ( n = 9 ) . Saline was administered in a comparable group of patients ( n = 10 ) . There were no significant differences in pain scores between the groups during the first day after surgery ( P>0.05 ) . Postoperative requirements of pethidine during the first 2 days after surgery did not differ significantly between the groups . Blood glucose levels were significantly lower in the bupivacaine‐treated group 1 h ( P<0.05 ) and 4 h ( P<0.05 ) after skin incision . No significant differences were observed between the groups regarding plasma catecholamine and serum cortisol levels during and after surgery . Differences between the groups regarding urine output of catecholamines during the first and second postoperative days were not significant . Our results suggest that single administration of a local anesthetic intraperitoneally does not reduce pain or the sympathoadrenal response to upper abdominal surgery
This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .