There was no significant change in the γGT levels .
Significant differences were not found .
CONCLUSION Silymarin minimally reduced , but without clinical relevance , the serum levels of ALT and AST .
AIM To evaluate the effect of silymarin on the serum levels of alanine aminotransferase ( ALT ) , aspartate aminotransferase ( AST ) and gamma glutamyl transpeptidase ( γGT ) in patients with liver diseases .
Hepatic effects of dietary weight loss in morbidly obese subjects.
This prospect i ve study was carried out in order to evaluate the influence on liver morphology and function of a very-low-calorie formula diet .  Fourty-one morbidly obese , non-alcoholic subjects had liver biopsy performed before and after a median weight loss of 34 kg . Fatty change improved ( p less than 0.001 ) , but 24 % of the patients developed slight portal inflammation ( p = 0.039 ) or slight portal fibrosis ( p = 0.063 ) . Patients developing portal fibrosis had a higher degree of fatty change at entry ( p = 0.029 ) , a more pronounced reduction of fatty change ( p = 0.014 ) and a faster weight loss ( p = 0.026 ) . Liver biochemistry , which was of no individual diagnostic value , improved . It is concluded that morbidly obese subjects with a high degree of hepatic fatty change are at risk of developing portal inflammation and fibrosis when undergoing very fast dietary weight reductions
There was no significant change in the γGT levels .
Significant differences were not found .
CONCLUSION Silymarin minimally reduced , but without clinical relevance , the serum levels of ALT and AST .
AIM To evaluate the effect of silymarin on the serum levels of alanine aminotransferase ( ALT ) , aspartate aminotransferase ( AST ) and gamma glutamyl transpeptidase ( γGT ) in patients with liver diseases .