Conclusion Various methods have been used at all stages of CSPBM development .
The choice between developing a classification system de novo or from an existing instrument may depend on the availability of a suitable existing measure , while the choice between a decomposed or composite approach appears to be determined primarily by the purpose for which the instrument is design ed .
Background Health state utility values ( HSUVs ) are required to calculate quality -adjusted life-years ( QALYs ) .
They are frequently derived from generic preference-based measures of health .
However , such generic measures may not capture health attributes of relevance to specific conditions .
In such cases , a condition-specific preference-based measure ( CSPBM ) may be more appropriate .
Objective This systematic review aim ed to identify all published accounts of developing CSPBMs to describe and appraise the methods used .
Estimating EQ-5D and OAB-5D health state utilities for patients with overactive bladder
Background Limited utility data on patients suffering from overactive bladder ( OAB ) are available in the literature . The objectives of this study were to estimate utility values in patients with OAB using the generic EQ-5D question naire and the OAB-5D disease specific question naire , to investigate the relationship between utilities and symptoms , and to evaluate the sensitivity of the two instruments to changes in symptom severity . Methods Analyses were based on pooled data from three large multicenter r and omized 12-week placebo-controlled trials ( SCORPIO , ARIES , CAPRICORN ) . Patients completed a micturition diary , EQ-5D and OAB-q ( a quality of life question naire from which OAB-5D is derived ) at baseline and at weeks 4 , 8 and 12 . Time trade-off tariffs elicited from UK population were applied to obtain utilities from both instruments . Repeated measures regressions were used to estimate EQ-5D and OAB-5D utilities by micturition frequency and incontinence severity level . As a test of sensitivity of the instruments , utility changes from baseline to week 12 were estimated by symptomatic response ( improvement , stable or worsening ) . Results The sample included 4427 patients . Mean utilities ( ± st and ard deviation ) across all visits were 0.82 ( ±0.21 ) for EQ-5D and 0.86 ( ±0.09 ) for OAB-5D . Correlation between EQ-5D and OAB-5D was 0.34 ( p < 0.0001 ) . Both OAB-5D and EQ-5D utilities increased as OAB symptoms improved . Utility values were similar for severe levels of symptoms , but higher with OAB-5D than with EQ-5D for mild cases . Micturitions and incontinence had similar impact on EQ-5D utilities , but micturitions had greater impact on OAB-5D utilities than incontinence . Changes from baseline in OAB-5D utilities differed significantly according to symptomatic response . Changes in EQ-5D utilities were not significantly associated with changes in micturition frequency and weakly associated with changes in incontinence severity among patients with mild symptoms at baseline . Conclusions This study showed that both EQ-5D and OAB-5D can detect changes in severity of OAB , especially in severe cases . However , OAB-5D is more sensitive than EQ-5D in measuring differences between treatments in milder cases . Both OAB-5D and EQ-5D – although leading to different results –may be useful to derive utilities from clinical trial data and perform cost-effectiveness analyses . Trial registration Clinical Trials NCT00689104 , NCT00662909 , NCT00912964
Conclusion Various methods have been used at all stages of CSPBM development .
The choice between developing a classification system de novo or from an existing instrument may depend on the availability of a suitable existing measure , while the choice between a decomposed or composite approach appears to be determined primarily by the purpose for which the instrument is design ed .
Background Health state utility values ( HSUVs ) are required to calculate quality -adjusted life-years ( QALYs ) .
They are frequently derived from generic preference-based measures of health .
However , such generic measures may not capture health attributes of relevance to specific conditions .
In such cases , a condition-specific preference-based measure ( CSPBM ) may be more appropriate .
Objective This systematic review aim ed to identify all published accounts of developing CSPBMs to describe and appraise the methods used .