Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .
Change in Levels of C-Reactive Protein (CRP) and Serum Cortisol in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy
Background C-Reactive protein ( CRP ) has been associated with the macro- and microvascular effects of hypertension and diabetes mellitus . Referring to serum cortisol , it has been proposed to contribute to the pathogenesis of metabolic syndrome , and it has been demonstrated that weight loss normalizes cortisol levels and improves insulin resistance . The aims of this study were to analyze CRP and cortisol levels pre- and postoperatively in morbidly obese patients undergoing a laparoscopic sleeve gastrectomy  and to correlate them with weight loss and parameters associated with cardiovascular risk . Methods A prospect i ve study of all the morbidly obese patients undergoing laparoscopic sleeve gastrectomy as bariatric procedure between October 2007 and May 2011 was performed . Results A total of 40 patients were included in the study .  CRP levels decreased significantly 12 months after surgery ( median reduction of 8.9 mg/l ; p = 0.001 ) . Serum cortisol levels decreased significantly 6 months after surgery ( median reduction of 34.9 μg/dl ; p = 0.001 ) . CRP values reached the normal range ( < 5 mg/l ) 1 year after surgery . Referring to cortisol , a significant association was observed with the cardiovascular risk predictor ( triglyceride/high-density lipoprotein cholesterol ratio ) from the 6th month after surgery onward ( Pearson correlation coefficient , 0.559 ; p = 0.008 ) . Conclusion CRP levels are increased preoperatively and in the postoperative course up to 1 year after surgery . Serum cortisol levels remain elevated until the 6th month after surgery . From this moment onward , serum cortisol is associated with the cardiovascular risk predictor reflecting the cardiovascular risk decreasement during the weight loss
Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .