Garlic reduces TC to a modest extent , an effect driven mostly by the modest reductions in TAG , without appreciable LDL lowering or HDL elevation .
Higher baseline line TC levels and the use of dietary modification may alter the effect of garlic on these parameters .
In order to determine the impact of  garlic on total cholesterol ( TC ) , TAG levels , as well as LDL and HDL  , and establish if any variables have an impact on the magnitude of this effect , a meta- analysis was conducted .
Aged garlic extract improves endothelial function in men with coronary artery disease.
Endothelium-dependent vasodilation is impaired and predicts the risk of a coronary event in patients with coronary artery disease ( CAD ) . Oxidant stress and increased systemic inflammation may contribute to this endothelial dysfunction . Aged garlic extract ( AGE ) contains antioxidant compounds and increases nitric oxide production and decreases the output of inflammatory cytokines from cultured cells . The aim of this study was to test the effect of treatment with AGE on brachial artery flow mediated endothelium-dependent dilation ( FMD ) and circulating markers of oxidative stress and systemic inflammation . The trial included 15 men with angiographically proven CAD in a r and omized , placebo-controlled , cross-over design with 2-week treatment and washout periods . During AGE supplementation , FMD increased ( 44 % ) significantly ( p = 0.04 ) from the baseline and mainly in men with lower baseline FMD . Levels of FMD at the end of AGE treatment were significantly ( p = 0.03 ) higher compared with the corresponding levels at the end of placebo treatment when the variation in baseline body weight was taken into account . Markers of oxidant stress ( plasma oxidized low density lipoprotein and peroxides ) , systemic inflammation ( plasma C-reactive protein ad interleukin-6 ) and endothelial activation ( VCAM-1 ) did not change significantly during the study . These data suggest that short-term treatment with AGE may improve impaired endothelial function in men with CAD treated with aspirin and a statin . Whether improvement in endothelial function decreases the risk of future cardiovascular events remains to be determined
Garlic reduces TC to a modest extent , an effect driven mostly by the modest reductions in TAG , without appreciable LDL lowering or HDL elevation .
Higher baseline line TC levels and the use of dietary modification may alter the effect of garlic on these parameters .
In order to determine the impact of  garlic on total cholesterol ( TC ) , TAG levels , as well as LDL and HDL  , and establish if any variables have an impact on the magnitude of this effect , a meta- analysis was conducted .