SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .
Placebo-controlled study of sertraline in depressed recently abstinent alcoholics
BACKGROUND Depression is common among recently abstinent alcoholics ; however , its treatment has been little studied . METHODS Thirty-six depressed recently abstinent alcoholics were r and omized in a 6-week double-blind placebo-controlled trial of sertraline 100 mg daily . RESULTS There was a significant group x time interaction for both the Hamilton Depression Rating Scale ( HDRS ) and the Beck Depression Inventory ( BDI ) . For the HDRS there were significant differences between the sertraline and placebo groups at weeks 3 and 6 and for the BDI at week 3 . Also , patients receiving sertraline had significantly lower mean posttreatment HDRS and BDI scores than patients receiving placebo . Furthermore , significantly more of the patients receiving sertraline obtained a Clinical Global Impression rating of " very much improved . " CONCLUSIONS Depressed recently abstinent alcoholics benefit from antidepressant medication
SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .