Due to the limited number of included trials , there is insufficient evidence to draw any conclusions about the effectiveness of cardiovascular prophylaxis in reducing mortality and cardiovascular events in people with AAA .
BACKGROUND Pharmacological prophylaxis has been proven to reduce the risk of cardiovascular events in individuals with atherosclerotic occlusive arterial disease .
However , the role of prophylaxis in individuals with abdominal aortic aneurysm ( AAA ) remains unclear .
Several studies have shown that despite successful repair , those people with AAA have a poorer rate of survival than healthy controls .
People with AAA have an increased prevalence of coronary heart disease and risk of cardiovascular events .
Despite this association , little is known about the effectiveness of pharmacological prophylaxis in reducing cardiovascular risk in people with AAA .
This is an up date of a Cochrane review first published in 2014 .
OBJECTIVES To determine the long-term effectiveness of antiplatelet , antihypertensive or lipid-lowering medication in reducing mortality and cardiovascular events in people with abdominal aortic aneurysm ( AAA ) .
Early and late outcome of surgical repair for small abdominal aortic aneurysms: a population-based analysis.
PURPOSE Whether small abdominal aortic aneurysms ( AAAs ) ( < or = 5 cm in diameter ) should be repaired early to enhance late survival remains controversial . Long-term population -based data on the surgical outcome for small AAAs may help to establish practice guidelines until r and omized clinical trials are completed . METHODS To examine an entire community experience with small AAAs , we conducted a population -based analysis of the recognition , reasons for operation , perioperative mortality rates , and late survival  in Olmsted County , Minnesota . RESULTS The incidence of recognized small AAAs increased thirtyfold during a 30-year period . The propensity to repair small AAAs also increased during the same period . Eventually one third of small AAAs were repaired . The primary reasons for surgical consultation and operation were presence of the aneurysm ( 49 % ) , expansion on serial examination ( 28 % ) , nonspecific abdominal or back symptoms ( 18 % ) , and excessive patient anxiety about the aneurysm ( 5 % ) . Community operative mortality rates for small AAAs were low ( 2.6 % ) compared with those for large aneurysms ( 5.5 % ) ( p = 0.65 ) . However , the observed 5-year survival rate for the group undergoing repair of small aneurysms was 62 % , which was significantly less than the 83 % expected survival for the general population ( p < 0.05 ) . Relative survival for the operated small and large aneurysms was similar . The primary cause of death for both groups was myocardial infa rct ion . CONCLUSIONS The results of our population -based analysis indicate that early operative results for elective repair of small AAAs are excellent , but late survival remains significantly impaired by coronary heart disease . Consequently , our data question whether early repair of small AAAs will enhance late survival . Until r and omized clinical trials on management of small AAAs are completed , most small AAAs should be monitored for expansion and operated on electively when they approach or enter the range of 5 to 6 cm in good-risk patients
Due to the limited number of included trials , there is insufficient evidence to draw any conclusions about the effectiveness of cardiovascular prophylaxis in reducing mortality and cardiovascular events in people with AAA .
BACKGROUND Pharmacological prophylaxis has been proven to reduce the risk of cardiovascular events in individuals with atherosclerotic occlusive arterial disease .
However , the role of prophylaxis in individuals with abdominal aortic aneurysm ( AAA ) remains unclear .
Several studies have shown that despite successful repair , those people with AAA have a poorer rate of survival than healthy controls .
People with AAA have an increased prevalence of coronary heart disease and risk of cardiovascular events .
Despite this association , little is known about the effectiveness of pharmacological prophylaxis in reducing cardiovascular risk in people with AAA .
This is an up date of a Cochrane review first published in 2014 .
OBJECTIVES To determine the long-term effectiveness of antiplatelet , antihypertensive or lipid-lowering medication in reducing mortality and cardiovascular events in people with abdominal aortic aneurysm ( AAA ) .