No significant difference was found between other treatments .
Conclusion Compared with antimuscarinic drugs , PTENS was associated with significant better efficacy considering MVV , but more constipation events in de novo OAB children .
Antimuscarinic drugs showed remarkably better efficacy considering MVV and comparable safety profile compared with urotherapy .
Objective To compare these managements focusing on the efficacy and safety to treat overactive bladder ( OAB ) in children through network meta- analysis ( NMA ) .
Transcutaneous parasacral electrical stimulation vs oxybutynin for the treatment of overactive bladder in children: a randomized clinical trial.
PURPOSE We determined the effectiveness of 2 methods to treat overactive bladder in children using intragroup and intergroup comparisons in a r and omized clinical trial . MATERIAL S AND METHODS Nine boys and 19 girls with a mean ± SD age of 6.4 ± 2.18 years were r and omly divided into group 1-parasacral transcutaneous electrical stimulation with placebo drug and group 2-oxybutynin with sham scapular electrical therapy . Success was assessed by 1 ) the rate of complete symptom resolution , 2 ) a visual analog scale of 0 to 10 , 3 ) the dysfunctional voiding score system , 4 ) voiding diary records , 5 ) Rome III criteria and 6 ) side effect frequency in each group . RESULTS A total of 13 and 15 patients were r and omized to groups 1 and 2 , respectively . Symptoms completely resolved in 6 patients in group 1 ( 46 % ) and 3 in group 2 ( 20 % ) ( p = 0.204 ) . A statistically significant improvement was found in the 2 groups in the dysfunctional voiding score system and voiding diary records . However , no statistically significant difference was found between the groups in the visual analog scale score , voiding frequency , and maximum and mean voided volume ( p = 0.295 , 0.098 , 0.538 and 0.650 , respectively ) . Constipation improved in 100 % of group 1 patients but in only 55 % in group 2 ( p = 0.031 vs 0.073 ) . Group 1 showed no side effects while dry mouth , hyperthermia and hyperemia developed in 58 % , 25 % and 50 % of group 2 patients ( p = 0.002 , 0.096 and 0.005 , respectively ) . Treatment was discontinued by 13.3 % of patients in group 2 . CONCLUSIONS Parasacral transcutaneous electrical stimulation was as effective as oxybutynin to treat overactive bladder in children . However , transcutaneous parasacral electrical stimulation was more effective against constipation and showed no detectable side effects . Oxybutynin was more effective for decreasing voiding frequency
No significant difference was found between other treatments .
Conclusion Compared with antimuscarinic drugs , PTENS was associated with significant better efficacy considering MVV , but more constipation events in de novo OAB children .
Antimuscarinic drugs showed remarkably better efficacy considering MVV and comparable safety profile compared with urotherapy .
Objective To compare these managements focusing on the efficacy and safety to treat overactive bladder ( OAB ) in children through network meta- analysis ( NMA ) .