Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Little evidence of systemic and adipose tissue inflammation in overweight individuals†
Context : The effect of weight loss by diet alone or diet in conjunction with exercise on low- grade inflammation in non-obese ( overweight ) individuals is not known . Objective : Test the hypothesis that 24 weeks of moderate calorie restriction ( CR ; 25 % ) by diet only or with aerobic exercise would reduce markers of systemic inflammation and attenuate inflammation gene expression in subcutaneous adipose tissue . Design : R and omized controlled trial . Setting : Institutional Research Center . Participants : Thirty-five overweight ( body mass index : 27.8 ± 0.7 kg/m2 ) but otherwise healthy participants ( 16M/19F ) completed the study . Intervention : Participants were r and omized to either CR ( 25 % reduction in energy intake , n = 12 ) , caloric restriction + exercise ( CR + EX : 12.5 % reduction in energy intake + 12.5 % increase in exercise energy expenditure , n = 12 ) , or control ( healthy weight-maintenance diet , n = 11 ) for 6 months . Main outcome measures : Fasting serum markers of inflammation [ leptin , highly sensitive C-reactive protein ( hsCRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-alpha ( TNF-α ) , adiponectin ] and inflammation-related genes [ CD68 , IL-6 , TNF-α , macrophage migration inhibitory factor ( MIF ) , monocyte chemoattractant protein-1 ( MCP-1 ) , adiponectin , plasminogen activator inhibitor-1 ( PAI-1 ) ] in subcutaneous adipose tissue . Results : CR and CR + EX lost similar amounts of body weight ( –10 ± 1 % ) , fat mass ( –24 ± 3 % ) , visceral fat ( –27 ± 3 % ) , and had increased insulin sensitivity ( CR : 40 ± 20 % , CR + EX : 66 ± 22 % ) . Leptin was significantly decreased from baseline ( p < 0.001 ) in both groups however TNF-α and IL-6 were not changed . hsCRP was decreased in CR + EX . There was no change in the expression of genes involved in macrophage infiltration ( CD68 , MIF MCP-1 , PAI-1 ) or inflammation ( IL-6 , TNF-α , adiponectin ) in either CR or CR + EX . Conclusion : A 10 % weight loss with a 25 % CR diet alone or with exercise did not impact markers of systemic inflammation or the expression of inflammation-related adipose genes in overweight individuals
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .