RESULTS Increased TFA intake did not result in significant changes in glucose or insulin concentrations .
Our analysis also showed the absence of publication bias and any dose-response relations between the ES and TFA intake .
Increased TFA intake does not result in changes in glucose , insulin , or triglyceride concentrations but leads to an increase in total and LDL-cholesterol and a decrease in HDL-cholesterol concentrations .
There is no evidence to support a potential benefit of the reduction of dietary TFA intake on glucose homeostasis
BACKGROUND Although evidence from cohort studies has suggested that trans fatty acid ( TFA ) consumption may be associated with insulin resistance and diabetes , r and omized placebo-controlled trials ( RCTs ) have yielded conflicting results .
OBJECTIVE In a meta- analysis , we combined all available RCTs that examined the role of  TFA intake  on  glucose homeostasis .
Dairy and industrial sources of trans fat do not impair peripheral insulin sensitivity in overweight women.
BACKGROUND The 2 major dietary sources of trans fatty acids ( TFAs ) are partially hydrogenated oils and ruminant-derived products . Epidemiologic data suggest that chronic consumption of industrial sources of TFAs could be damaging to insulin sensitivity , but intervention studies on this issue have remained inconclusive . OBJECTIVE The trial was design ed to compare the effects of dairy compared with industrial sources of TFAs on insulin sensitivity in overweight women . DESIGN Sixty-three healthy women with abdominal obesity [ waist circumference > 88 cm and a body mass index ( in kg/m(2 ) ) > 28 ] were recruited . After a run-in period , the volunteers were r and omly assigned to consume 1 of 3 four-week diets : 60 g low-TFA lipids/d ( 0.54 g/d ; n = 21 ) , ruminant TFA-rich lipids ( 4.86 g/d ; n = 21 ) , or industrial TFA-rich lipids ( 5.58 g/d ; n = 21 ) . Changes in peripheral insulin sensitivity were assessed by using hyperinsulinemic-euglycemic clamps . RESULTS After the intervention period , fasting glycemia and insulinemia and insulin sensitivity were not significantly modified in either group ( P > 0.05 ) . CONCLUSIONS These data indicate that consumption of dairy- and industrial- source TFAs for 4 wk at nutritional levels do not impair peripheral insulin sensitivity in insulin-resistant women . Our study may not preassess the effects of TFAs in normal insulin-sensitive individuals . This trial was registered at Clinical Trials.gov as NCT00617435
RESULTS Increased TFA intake did not result in significant changes in glucose or insulin concentrations .
Our analysis also showed the absence of publication bias and any dose-response relations between the ES and TFA intake .
Increased TFA intake does not result in changes in glucose , insulin , or triglyceride concentrations but leads to an increase in total and LDL-cholesterol and a decrease in HDL-cholesterol concentrations .
There is no evidence to support a potential benefit of the reduction of dietary TFA intake on glucose homeostasis
BACKGROUND Although evidence from cohort studies has suggested that trans fatty acid ( TFA ) consumption may be associated with insulin resistance and diabetes , r and omized placebo-controlled trials ( RCTs ) have yielded conflicting results .
OBJECTIVE In a meta- analysis , we combined all available RCTs that examined the role of  TFA intake  on  glucose homeostasis .