Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .
Caffeine increases aortic stiffness in hypertensive patients.
BACKGROUND Caffeine is the most widely used pharmacologic substance . Aortic stiffness is an important factor for cardiovascular system performance and a prognosticator of cardiovascular risk . We investigated the effect of caffeine on aortic stiffness in treated hypertensive patients . METHODS We studied the effect of caffeine ( 250 mg ) in 12 treated hypertensive patients according to a r and omized , placebo-controlled  , double-blind , cross-over design during a 3-h period . Aortic stiffness was evaluated by carotid-femoral pulse wave velocity . RESULTS Systolic blood pressure ( BP ) and pulse pressure increased significantly throughout the study ( by 12.3 and 7.4 mm Hg , P = .005 and P < .01 , respectively ) , whereas diastolic BP did not change . Pulse wave velocity increased ( by 0.57 m/sec , P < .05 ) denoting an increase in aortic stiffness . This effect of caffeine lasted throughout the study ( 3 h ) , peaking at 60 min and decreasing progressively thereafter . CONCLUSIONS These results demonstrate , for the first time , that caffeine exerts an acute unfavorable effect on aortic stiffness in treated hypertensive patients . This finding has important implication s for the impact of caffeine consumption on cardiovascular risk in hypertension
Conclusion : The results from this meta- analysis suggest a beneficial short-term effect of coffee intake on EF as measured by FMD .
Base on systematic review results acute and chronic intake of coffee products may exerts an unfavorable effect on AS .
Background : Endothelial function ( EF ) and arterial stiffness ( AS ) are predictors of cardiovascular disease .
As previous research concerning the effect of coffee intake on EF and AS was controversial , we conducted a systematic review and meta- analysis to synthesize research .