In conclusion , bariatric surgery is associated with a reduction in specific adipokines including leptin , chemerin , and PAI-1 , whereas adiponectin is raised , adaptations that could be indicative of improved fat mass and function
Different adipokines secreted from adipose tissue , exert a range of physiological effects .
The aim of present systematic review and meta- analysis was to critically investigate the consequence of  bariatric surgery on circulating adipokines , that is , adiponectin , leptin , visfatin , resistin , plasminogen activator inhibitor , and chemerin .
Plasma ghrelin in obesity before and after weight loss after laparoscopical adjustable gastric banding.
Weight reduction after gastric bypass surgery  has been attributed to a decrease of the orexigenic peptide ghrelin , which may be regulated by insulin and leptin . This study examined effects of long-term weight loss  after laparoscopical adjustable gastric b and ing  on plasma ghrelin and leptin concentrations and their relationship with insulin action . Severely obese patients ( 15 women , three men , 36 + /- 12 yr ) underwent clinical examinations every 3 months and modified oral glucose tolerance tests to assess parameters of insulin sensitivity and secretion every 6 months . After surgery , body mass index fell from 45.3 + /- 5.3 to 37.2 + /- 5.3 and 33.6 + /- 5.5 kg/m(2 ) at 6 and 12 months , respectively ( P < 0.0001 ) . This was associated with lower ( P < 0.0001 ) plasma glucose , insulin , insulin resistance , waist circumference , and blood pressure . Plasma leptin decreased from 27.6 + /- 9.5 to 17.7 + /- 9.8 ( P = 0.0005 ) and 12.7 + /- 5.1 ng/ml ( P < 0.0001 ) . Plasma ghrelin was comparable before and at 6 months ( 234 + /- 53 ; 232 + /- 53 pmol/liter ) but increased at 12 months ( 261 + /- 72 pmol/liter ; P = 0.05 vs. 6 months ) . At 6 and 12 months , ghrelin levels correlated negatively with fasting plasma insulin levels and hepatic insulin extraction but not with body mass or insulin action . In conclusion , prolonged weight loss results in a rise of fasting ghrelin concentrations that correlates with fasting insulin concentrations but not improvement of insulin sensitivity
In conclusion , bariatric surgery is associated with a reduction in specific adipokines including leptin , chemerin , and PAI-1 , whereas adiponectin is raised , adaptations that could be indicative of improved fat mass and function
Different adipokines secreted from adipose tissue , exert a range of physiological effects .
The aim of present systematic review and meta- analysis was to critically investigate the consequence of  bariatric surgery on circulating adipokines , that is , adiponectin , leptin , visfatin , resistin , plasminogen activator inhibitor , and chemerin .