LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Adherence to statins in primary prevention: yearly adherence changes and outcomes.
BACKGROUND Adherence to statins in real-world practice setting s is known to be suboptimal . However , less is known about how adherence changes over time and whether changes in adherence are associated with adverse cardiovascular ( CV ) outcomes . OBJECTIVES To ( a ) characterize yearly changes in adherence among initially adherent patients taking statins for primary prevention and ( b ) assess the association between changes in statin adherence with subsequent risk of CV events . METHODS A 10 % r and om sample of the IMS LifeLink Health Plan Cl aims Data base covering the time period from July 1 , 1997 , to December 31 , 2008 , was used to identify a cohort of primary prevention statin users .  Adherence was estimated in yearly segments beginning with the index statin prescription using proportion of days covered ( PDC ) . PDC was categorized into 3 levels : PDC ≥ 0.80 , 0.20 ≤ PDC < 0.80 , PDC < 0.20 . Patients were excluded if they experienced CV events or had PDC < 0.80 in their first year of statin exposure . Descriptive statistics were used to explore proportions of the cohort in each PDC category during each year . Cox-proportional hazards models were used to estimate the 5-year CV event risk associated with yearly adherence transitions . RESULTS Of the 11,126 patients beginning at the highest level of adherence ( PDC ≥ 0.80 ) in year 1 , 70 % remained at this level in year 2 . Of those in this level during year 2 , 73 % remained at this level in year 3 . 828 ( 7.44 % ) experienced a CV event during their observable follow-up time . It was found that those who transitioned from the highest to the lowest level of adherence in year 2 ( PDC < 0.20 ) experienced 2.26 greater CV event hazard ( P < 0.0001 ) . Adjusting for year 2 adherence , patients at the lowest level in year 3 experienced a 271 % increase in CV hazard ( P < 0.0001 ) , as compared with the highest level of adherence . CONCLUSION This study found that  patients ' adherence levels tend to decline over time , and a transition to levels of adherence lower than a PDC of 80 % was associated with increased risk of CV events . These results are useful in the context of targeting interventions that aim to improve patients ' adherence
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .