Taken together , the clinical work to date suggests that the highest fertility rates and the lowest complication rates are associated with the microsurgical subinguinal surgical approach to varicocelectomy .
Abstract Despite being first described two thous and years ago , the varicocele remains a controversial multifaceted disease process with numerous biological consequences including infertility , hypogonadism , and chronic orchidalgia .
The underlying mechanisms remain poorly understood and likely include hypoxia , oxidative stress , hyperthermia , anatomical aberrations , and genetics as primary components .
Despite a high prevalence amongst asymptomatic fertile men , varicoceles paradoxically also represent the most common correctable cause for male infertility .
In this systematic review we discuss the rich historical aspects of the varicocele and the contemporary data regarding its clinical manifestations .
We performed a systematic literature review with the goal of comparing outcomes and complication rates of each of the major surgical approaches as they relate to infertility and pain .
Study of the effect of varicocelectomy on sperm proteins expression in patients with varicocele and poor sperm quality by using two-dimensional gel electrophoresis
Purpose To compare proteomic profiles of spermatozoa from patients with varicocele and poor sperm quality before and after varicocelectomy . Methods This work was design ed as a prospect i ve and observational study . The study was based on 20 men with varicocele grade 3 and poor sperm quality undergoing varicocelectomy at the Fertility Unit of Royan institute in 2009 . Two semen sample s were collected , one before varicocelectomy and the other after surgery . Protein separation was done by two-dimensional protein electrophoresis , and analyzed by gel densitometry and mass spectrometry . Differential sperm protein expression levels were measured by gel densitometry . Results Comparison of the sperm parameters showed that sperm motility and concentration were increased after varicocelectomy . At the level of protein , a total of 3 protein spots were identified whose expression was significantly lower in sperm sample s before varicocelectomy compared with after surgery including heat shock protein A5 ( HSPA5 ) , superoxide dismutase 1 ( SOD1 ) and δ-subunit of the catalytic core of mitochondrial adenosine triphosphate synthase ( ATP5D ) . Conclusions High grade varicocoele affects sperm protein expression presumably because of increasing testicular temperature . These proteins play essential roles in sperm production , DNA integrity protection , and sperm motility . This novel study demonstrates that varicocelectomy can improve both sperm quality and proteins expression
Taken together , the clinical work to date suggests that the highest fertility rates and the lowest complication rates are associated with the microsurgical subinguinal surgical approach to varicocelectomy .
Abstract Despite being first described two thous and years ago , the varicocele remains a controversial multifaceted disease process with numerous biological consequences including infertility , hypogonadism , and chronic orchidalgia .
The underlying mechanisms remain poorly understood and likely include hypoxia , oxidative stress , hyperthermia , anatomical aberrations , and genetics as primary components .
Despite a high prevalence amongst asymptomatic fertile men , varicoceles paradoxically also represent the most common correctable cause for male infertility .
In this systematic review we discuss the rich historical aspects of the varicocele and the contemporary data regarding its clinical manifestations .
We performed a systematic literature review with the goal of comparing outcomes and complication rates of each of the major surgical approaches as they relate to infertility and pain .