Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .
Acute haemodynamic effects of testosterone in men with chronic heart failure.
AIMS Anabolic therapy with testosterone may be useful in the treatment of wasting associated with chronic heart failure but little is known about its cardiovascular actions . The aim of this study was to determine the acute haemodynamic effects of testosterone administration in men with heart failure . METHODS AND RESULTS Twelve men with stable chronic heart failure were enrolled in a double-blind , r and omised , placebo-controlled , cross-over trial . Subjects were given testosterone 60 mg or placebo via the buccal route and central haemodynamics were monitored over 6h , using a pulmonary flotation catheter . Subjects received the second treatment on day 2 and haemodynamic monitoring was repeated . Treatment was well tolerated . Compared with placebo , testosterone treatment result ed in a relative increase in cardiac output ( p<0.0001 , ANCOVA ) , with maximum treatment effect after 180 min ( 10.3+/-4.6 % increase from baseline , p=0.035 ; 95 % CI 0.8 - 19.8 ) . This was accompanied by reduction in systemic vascular resistance compared with baseline ( p<0.0001 , ANCOVA ) , with maximum treatment effect also at 180 min ( -17.4+/-9.6 % from baseline , p=0.085 ; 95 % CI -37.3 to + 2.6 ) . These maximal changes coincided with the peak elevation in serum bio-available testosterone . There was no significant change in any other haemodynamic parameter measured . CONCLUSIONS Administration of testosterone increases cardiac output acutely , apparently via reduction of left ventricular afterload
Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .