Our meta‐ analysis showed beneficial effects  of statin use  on reducing inflammatory markers in patients with MetS and related disorders
& NA ; Current evidence suggests that statin use decreases the incidence of cardiovascular diseases ( CVD ) through reducing LDL cholesterol and decreasing inflammation .
Metabolic syndrome ( MetS ) is usually associated with increased inflammatory markers and increased risk of CVD .
Effects of atorvastatin on low-density lipoprotein cholesterol phenotype and C-reactive protein levels in patients undergoing long-term dialysis.
STUDY OBJECTIVES To determine the effects of atorvastatin on low-density lipoprotein cholesterol ( LDL ) particle size and C-reactive protein ( CRP ) concentrations in patients undergoing long-term hemodialysis . Another objective was to compare the effects of atorvastatin on lipoprotein profiles as determined by direct versus indirect assessment of lipoprotein composition . DESIGN R and omized , parallel-group sub study . SETTING Two university-affiliated outpatient hemodialysis centers . PATIENTS Nineteen patients with LDL levels above 100 mg/dl and with at least two cardiovascular risk factors . INTERVENTION Patients were r and omized in a 1:1 ratio to atorvastatin 10 mg/day or no treatment ( control ) for 20 weeks . MEASUREMENTS AND MAIN RESULTS We compared the differences between LDL particle size and CRP levels at baseline and 20 weeks in the atorvastatin versus control groups . Baseline demographic characteristics were similar between the two groups . Atorvastatin therapy was associated with no change in mean LDL particle size ( p=0.23 ) and with a 90 % decrease in mean CRP level ( p=0.52 ) . When evaluated by st and ard chemical analysis , atorvastatin therapy reduced total cholesterol levels by 29 % ( p=0.025 ) and result ed in nonsignificant reductions in LDL , high-density lipoprotein cholesterol , and triglyceride levels . Treatment with atorvastatin was not associated with significant changes in lipoprotein profile as determined by nuclear magnetic resonance ( NMR ) spectroscopy . CONCLUSION Treatment with atorvastatin did not affect LDL particle size but was associated with a sizable , yet nonsignificant , reduction in CRP concentrations . The drug had variable effects on lipoprotein concentrations as determined by chemical and NMR analytical methods . A larger study is necessary to provide definitive information on the effects of atorvastatin on LDL phenotype and CRP in patients with kidney disease
Our meta‐ analysis showed beneficial effects  of statin use  on reducing inflammatory markers in patients with MetS and related disorders
& NA ; Current evidence suggests that statin use decreases the incidence of cardiovascular diseases ( CVD ) through reducing LDL cholesterol and decreasing inflammation .
Metabolic syndrome ( MetS ) is usually associated with increased inflammatory markers and increased risk of CVD .