AUTHORS ' CONCLUSIONS Addition of ox and rolone to the GH therapy led to a modest increase in the final adult height of girls aged up to 18 years with TS .
BACKGROUND The final adult height of untreated girls aged up to 18 years with Turner syndrome ( TS ) is approximately 20 cm shorter compared with healthy females .
Treatment with growth hormone ( GH ) increases the adult height of people with TS .
The effects of adding the and rogen , ox and rolone , in addition to GH are unclear .
Therefore , we conducted this systematic review to investigate the benefits and harms of ox and rolone as an adjuvant therapy for people with TS treated with GH .
OBJECTIVES To assess the effects of ox and rolone on growth hormone-treated girls aged up to 18 years with Turner syndrome .
Three-year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome.
Seventy girls with Turner syndrome , 4 to 12 years of age , participated in a prospect i ve , r and omized study to determine the effects on growth of methionyl human growth hormone ( met-hGH ) or ox and rolone . Subjects were r and omly assigned to receive either no treatment ( control ) or met-hGH ( 0.125 mg/kg three times per week ) , ox and rolone ( 0.125 mg/kg/day ) , or combination met-hGH plus ox and rolone . At the end of an initial period of 12 to 20 months , patients in the original control and ox and rolone groups were given combination met-hGH plus ox and rolone . At that time the dosage of ox and rolone was lowered to 0.0625 mg/kg/day . Sixty-five subjects have now completed the first 3 years of the study . Compared with the control growth rate for year 1 ( 3.8 cm/yr ) , significant increases in growth rate were seen in all 3 years of combination therapy ( 9.8 , 7.4 , and 6.1 cm/yr , respectively ) and in the first 2 years of treatment with met-hGH alone ( 6.6 , 5.4 , and 4.6 cm/yr ) . When growth velocity was expressed as st and ard deviation for age in girls with Turner syndrome , significant increases relative to the control group for year 1 ( -0.1 SD ) were seen in all three years of both combination therapy and met-hGH alone ( combination , + 6.6 , + 4.3 , + 3.0 SD ; met-hGH , + 3.1 , + 2.0 , + 1.4 SD ) . After 3 years of treatment , predicted adult height by the method of Bayley-Pinneau increased 4.5 cm in the met-hGH group and 8.2 cm in the combination group
AUTHORS ' CONCLUSIONS Addition of ox and rolone to the GH therapy led to a modest increase in the final adult height of girls aged up to 18 years with TS .
BACKGROUND The final adult height of untreated girls aged up to 18 years with Turner syndrome ( TS ) is approximately 20 cm shorter compared with healthy females .
Treatment with growth hormone ( GH ) increases the adult height of people with TS .
The effects of adding the and rogen , ox and rolone , in addition to GH are unclear .
Therefore , we conducted this systematic review to investigate the benefits and harms of ox and rolone as an adjuvant therapy for people with TS treated with GH .
OBJECTIVES To assess the effects of ox and rolone on growth hormone-treated girls aged up to 18 years with Turner syndrome .