These studies demonstrated improvement in biochemical profiles , with a decline in or normalization of liver enzymes .
However , some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis .
There has been a growing interest in the role of vitamin E supplementation in the treatment and /or prevention of nonalcoholic fatty liver ( NAFLD ) .
Furthermore , histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only .
Effect of lifestyle intervention on non-alcoholic fatty liver disease in Chinese obese children.
AIM To investigate the effect of lifestyle intervention on  non-alcoholic fatty liver disease ( NAFLD ) in Chinese obese children . METHODS Seventy-six obese children aged from 10 to 17 years with NAFLD were enrolled for a one-month intervention and divided r and omly into three groups . Group1 , consisting of 38 obese children , was an untreated control group without any intervention . Group 2 , consisting of 19 obese children in summer camp , was strictly controlled only by life style intervention . Group 3 , consisting of 19 obese children , received oral vitamin E therapy at a dose of 100 mg/d . The height , weight , fasting blood glucose ( FBG ) , fasting serum insulin ( FINS ) , plasma alanine aminotransferase ( ALT ) , aspartate aminotransferase ( AST ) , triglyceride ( TG ) , total cholesterol ( TCHO ) and homeostasis model assent-insulin resistance ( HOMA-IR ) were measured at baseline and after one month . All patients were underwent to an ultrasonographic study of the liver performed by one operator who was blinded to the groups . RESULTS The monitor indices of BMI , ALT , AST , TG , TCHO and HOMA-IR were successfully improved except in group 1 . BMI and ALT in group 2 were reduced more significantly than in group 3 ( 2.44 + /- 0.82 vs 1.45 + /- 0.80 , P = 0.001 ; 88.58 + /- 39.99 vs 63.69 + /- 27.05 , P = 0.040 , respectively ) . CONCLUSION Both a short-term lifestyle intervention and vitamin E therapy have an effect on NAFLD in obese children . Compared with vitamin E , lifestyle intervention is more effective . Therefore , lifestyle intervention should represent the first step in the management of children with NAFLD
These studies demonstrated improvement in biochemical profiles , with a decline in or normalization of liver enzymes .
However , some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis .
There has been a growing interest in the role of vitamin E supplementation in the treatment and /or prevention of nonalcoholic fatty liver ( NAFLD ) .
Furthermore , histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only .