Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .
Evaluation of Lactobacillus coryniformis CECT5711 strain as a coadjuvant in a vaccination process: a randomised clinical trial in healthy adults
Background Although the effects of probiotics on the immune system have been extensively evaluated under disease states , their role in healthy situations remains unclear , since changes are hardly expected under immunological homeostasis . EFSA indicates that vaccination protocol s could be used to evaluate the potential role of probiotics to improve the immune response against antigen challenges . The aim of the study was to evaluate the effect of Lactobacillus coryniformis CECT5711 ( Lc ) on the specific immunity of healthy volunteers undergoing vaccination with Hepatitis A virus ( HAV ) . Methods One hundred twenty-three healthy adults were r and omised into three groups to follow a 6-week ( wk ) intervention and all received an intramuscular HAV vaccine 2 weeks after starting the intervention : 1 ) PRO1 received Lc for 2weeks ( 1 capsule/day ; 3 × 109 CFU/capsule ) and placebo capsules after vaccination ; 2 ) PRO2 received a daily capsule of Lc ( 3 × 109 cfu/day ) before and after the challenge ; 3 ) Control group ( C ) received a daily placebo capsule before and after the vaccine .  Blood sample s were collected at the beginning ( visit 1 ; V1 ) and after 2 ( V2 ) and 6 weeks ( V3 ) of the intervention . At each visit , lymphocyte subset counts and cytokine levels were analysed . Specific HAV antibodies were analysed at V1 and V3 . To evaluate differences between groups , one-way ANOVA with Bonferroni post-hoc test were used regarding lymphocyte subset counts and specific HAV antibodies production , and Friedman test of related sample s and Kendall concordance coefficient for cytokines production . Chi square test was used to analyse seroconversion rates . Results Specific HAV antibodies were significantly higher in PRO1 ( 50.54 ± 29.57 ) compared to C ( 36.23 ± 16.45 ) ( P = 0.017 ) and showed an intermediate value in PRO2 ( 41.61 ± 15.74 ) . Seroconversion rates were similar in the three groups ( 97.3 , 92.3 and 97.4 % in C , PRO1 and PRO2 respectively ) . Memory T-helper lymphocytes increased in V3 vs. V1 ( P = 0.032 ) in PRO2 . No differences were found in cytokine concentrations . Conclusion Mixed results have been found regarding the usefulness of Lc supplementation to increase the antigen-specific antibody response to an immune challenge . Clinical trial registration number : EudraCT Number 2016 - 000183 - 42 . Registered 19 January 2016 . Retrospectively registered
Conclusions Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines including , hs-CRP , TNF-a , IL-6 , IL-12 , and IL-4 , but it did not influence IL-1B , IL-8 , IFN-g , and IL-17 concentrations .
A significant increase in serum concentrations of IL-10 , as a anti-inflammatory cytokine was also documented after probiotic supplementation
Purpose No study has summarized earlier findings on the effect of probiotic supplementation on  inflammatory biomarkers .
This systematic review and meta- analysis was conducted to systematic ally review the available placebo-controlled clinical trials about the effect of probiotic supplementation  on several inflammatory biomarkers in adults .