IMPLICATION S Available evidence from RCTs suggests that resveratrol supplementation significantly reduced TNF-α and hs-CRP levels .
Significant improvement in inflammatory markers  support resveratrol as an adjunct to pharmacologic management of metabolic diseases
PURPOSE The evidence has suggested that resveratrol has anti-inflammatory effect ; however , the results are inconsistent and inconclusive .
The aim of this study was to assess the effect of resveratrol supplementation on the levels of inflammatory markers through a systematic review and meta- analysis of available r and omized controlled trials ( RCTs ) .
Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia-reperfusion injury: role of Nrf2/ARE pathway.
The protective role of resveratrol in myocardial ischemia/reperfusion is not well understood . The aim of this study was to investigate whether resveratrol modulates inflammation and oxidative stress and the possible role of nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element ( ARE ) pathway in an ischemia/reperfusion injured rat heart model . Rats were r and omly exposed to sham operation , myocardial ischemia/reperfusion ( MI/R ) alone , and MI/R + resveratrol . The results demonstrated that compared to MI/R , resveratrol improved cardiac function , reduced myocardial infa rct ion area , myocardial myeloperoxidase ( MPO ) levels , serum creatinine kinase ( CK ) and lactate dehydrogenase ( LDH ) levels .  Resveratrol also markedly enhanced the activities of antioxidant enzymes superoxide dismutase ( SOD ) and glutathione peroxidase ( GSH-PX ) , and reduced the level of malondialdehyde ( MDA ) in MI/R rats . Resveratrol also enhanced levels of Nrf2 and heme oxygenase-1 . In summary , these results demonstrated that resveratrol exerted significant antioxidant and cardioprotective effects following myocardial ischemia , possibly through the activation of the Nrf2/ARE signaling pathway
IMPLICATION S Available evidence from RCTs suggests that resveratrol supplementation significantly reduced TNF-α and hs-CRP levels .
Significant improvement in inflammatory markers  support resveratrol as an adjunct to pharmacologic management of metabolic diseases
PURPOSE The evidence has suggested that resveratrol has anti-inflammatory effect ; however , the results are inconsistent and inconclusive .
The aim of this study was to assess the effect of resveratrol supplementation on the levels of inflammatory markers through a systematic review and meta- analysis of available r and omized controlled trials ( RCTs ) .