The review of trials identifies positive effects of these nutrients on various outcome measures relating to insulin resistance and cardiovascular factors .
A majority of the trials found a positive effect of chromium on fasting plasma glucose .
Isoflavones were found to have a positive effect on insulin resistance and cardiovascular outcome measures , but only when combined with soy proteins .
Vitamin E is reported to reduce oxidative stress at levels of 200 mg day(-1 ) or more
The role of nutritional supplementation is of increasing interest with regard to ocular disease .
R and omised controlled trials have demonstrated the effectiveness of supplementation for age-related macular degeneration , and formulations are now being developed for use by people with diabetes and diabetic retinopathy .
The aim of this review was to synthesis e the evidence for use of nutritional supplementation in type 2 diabetes .
The potential role of alpha-lipoic acid , chromium , folic acid , isoflavones , magnesium , Pycnogenol , selenium , vitamin C , vitamin E , and zinc in the treatment of type 2 diabetes is discussed .
The effects of inorganic chromium and brewer's yeast supplementation on glucose tolerance, serum lipids and drug dosage in individuals with type 2 diabetes.
OBJECTIVE To study the effects of supplementation with organic and inorganic chromium on glucose tolerance , serum lipids , and drug dosage in type 2 diabetes patients , in the hope of finding a better and more economical method of control . METHODS Seventy eight type 2 diabetes patients were divided r and omly into two groups and given Brewer 's yeast ( 23.3ug Cr/day ) , and CrCl3 ( 200ug Cr/day ) sequentially with placebo in between , in a double blind cross-over design of four stages , each lasting 8 weeks . At the beginning and end of each stage , subjects were weighed , their dietary data and drug dosage recorded , and blood and urine sample s were collected for analysis of glucose ( fasting and 2 hour post 75 g glucose load ) fructosamine , triglycerides , total and HDL-cholesterol , and serum and urinary chromium . RESULTS Both supplements caused a significant decrease in the means of glucose ( fasting and 2 hour post glucose load ) , fructosamine and triglycerides . The means of HDL-cholesterol , and serum and urinary chromium were all increased . The mean drug dosage decreased slightly ( and significantly in case of Glibenclamide ) after both supplements and some patients no longer required insulin . No change was noted in dietary intakes or Body Mass Index . A higher percentage of subjects responded positively to Brewer 's yeast chromium , which was retained more by the body , with effects on fructosamine , triglycerides , and HDL-cholesterol maintained in some subjects when placebo followed it , and mean urinary chromium remaining significantly higher than zero time mean . CONCLUSION Chromium supplementation gives better control of glucose and lipid variables while decreasing drug dosage in type 2 diabetes patients . A larger scale study is needed to help decide on the convenient chemical form , and dosage required to achieve optimal response
The review of trials identifies positive effects of these nutrients on various outcome measures relating to insulin resistance and cardiovascular factors .
A majority of the trials found a positive effect of chromium on fasting plasma glucose .
Isoflavones were found to have a positive effect on insulin resistance and cardiovascular outcome measures , but only when combined with soy proteins .
Vitamin E is reported to reduce oxidative stress at levels of 200 mg day(-1 ) or more
The role of nutritional supplementation is of increasing interest with regard to ocular disease .
R and omised controlled trials have demonstrated the effectiveness of supplementation for age-related macular degeneration , and formulations are now being developed for use by people with diabetes and diabetic retinopathy .
The aim of this review was to synthesis e the evidence for use of nutritional supplementation in type 2 diabetes .
The potential role of alpha-lipoic acid , chromium , folic acid , isoflavones , magnesium , Pycnogenol , selenium , vitamin C , vitamin E , and zinc in the treatment of type 2 diabetes is discussed .