Subgroup analyses showed the most marked relation between sugar intakes and lipids in studies in which efforts were made to ensure an energy balance and when no difference in weight change was reported .
CONCLUSIONS Dietary sugars  influence blood pressure and serum lipids .
The relation is independent of effects of  sugars on body weight .
BACKGROUND Dietary sugars have been suggested as a cause of obesity , several chronic diseases , and a range of cardiometabolic risk factors , but there is no convincing evidence of a causal relation between sugars and risk factors other than body weight .
OBJECTIVE We conducted a systematic review and meta- analysis of r and omized controlled trials that examined effects of the modification of dietary free sugars on blood pressure and lipids .
Effect of Eucaloric High- and Low-Sucrose Diets With Identical Macronutrient Profile on Insulin Resistance and Vascular Risk
The long-term impact of dietary carbohydrate type , in particular sucrose , on insulin resistance and the development of diabetes and atherosclerosis is not established . Current guidelines for the healthy population advise restriction of sucrose intake . We investigated the effect of high- versus low-sucrose diet ( 25 vs. 10 % , respectively , of total energy intake ) in 13 healthy subjects aged 33 ± 3 years ( mean ± SE ) , BMI 26.6 ± 0.9 kg/m2 , in a r and omized crossover design with sequential 6-week dietary interventions separated by a 4-week washout . Weight maintenance , eucaloric diets with identical macronutrient profiles and fiber content were design ed . All food was weighed and distributed . Insulin action was assessed using a two-step euglycemic clamp ;  glycemic profiles were assessed by the continuous glucose monitoring system and vascular compliance by pulse-wave analysis . There was no change in weight across the study . Peripheral glucose uptake and suppression of endogenous glucose production were similar after each diet . Glycemic profiles and measures of vascular compliance did not change . A rise in total and LDL cholesterol was observed . In this study , a high-sucrose intake as part of an eucaloric , weight-maintaining diet had no detrimental effect on insulin sensitivity , glycemic profiles , or measures of vascular compliance in healthy nondiabetic subjects
Subgroup analyses showed the most marked relation between sugar intakes and lipids in studies in which efforts were made to ensure an energy balance and when no difference in weight change was reported .
CONCLUSIONS Dietary sugars  influence blood pressure and serum lipids .
The relation is independent of effects of  sugars on body weight .
BACKGROUND Dietary sugars have been suggested as a cause of obesity , several chronic diseases , and a range of cardiometabolic risk factors , but there is no convincing evidence of a causal relation between sugars and risk factors other than body weight .
OBJECTIVE We conducted a systematic review and meta- analysis of r and omized controlled trials that examined effects of the modification of dietary free sugars on blood pressure and lipids .