Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .
Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study.
OBJECTIVE To examine whether 3 months of lipoic acid ( LA ) supplementation improved walking tolerance and delayed claudication pain onset in peripheral arterial disease ( PAD ) . DESIGN R and omized , double-blind , controlled study . SETTING General Clinical Research Center . SUBJECTS Twenty-eight ( 28 ) participants ( 15 men , 13 women ) with PAD ( ankle brachial index range 0.9 - 0.4 , mean age 73.2 + /- 1.6 years ) . INTERVENTION LA ( 600 mg/day ) or placebo for 3 months . OUTCOME MEASURES Walking tolerance was assessed by 6-minute walk test distance , 4-meter walk time , initial claudication pain time ( ICT ) and distance ( ICD ) , and peak claudication pain . Serum was assessed for inflammation ( C-reactive protein [ CRP ] ) and oxidative stress ( lipid hydroperoxides ) as potential mechanisms for changes in walking tolerance . RESULTS ICT increased 34.4 % and 15 % , ICD was reduced by 40.5 % and 18 % , and peak claudication pain ratings were reduced by 93 % and 7 % in LA and placebo groups , respectively . Although the improvements in peak pain and ICT achieved significance within the LA group ( both p<0.05 ) , the interactions of group by time were not found to be significant ( p>0.05 ) . Oxidative stress and CRP measures were not different between groups by month 3 ( p>0.05 ) . There were no serious side-effects associated with the LA . CONCLUSIONS LA may confer pain relief during exercise . However , longer and larger trials are warranted to determine long-term effects of LA alone or combined with other interventions on PAD symptoms
Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .