Comparison of PO diets with diets rich in stearic acid , monounsaturated fatty acids ( MUFAs ) , and polyunsaturated fatty acids ( PUFAs ) showed significantly higher TC , LDL cholesterol , apolipoprotein B , HDL cholesterol , and apolipoprotein A-I , whereas most of the same biomarkers were significantly lower when compared with diets rich in myristic/lauric acid .
Comparison of PO-rich diets with diets rich in trans fatty acids showed significantly higher concentrations of HDL cholesterol and apolipoprotein A-I and significantly lower apolipoprotein B , triacylglycerols , and TC/HDL cholesterol .
Stratified and meta-regression analyses showed that the higher concentrations of TC and LDL cholesterol , when PO was substituted for MUFAs and PUFAs , were not significant in young people and in subjects with diets with a lower percentage of energy from fat .
Both favorable and unfavorable changes in CHD/CVD risk markers occurred when PO was substituted for the primary dietary fats , whereas only favorable changes occurred when PO was substituted for trans fatty acids .
BACKGROUND Palm oil ( PO ) may be an unhealthy fat because of its high saturated fatty acid content .
OBJECTIVE The objective was to assess the effect of substituting PO for other primary dietary fats on blood lipid-related markers of coronary heart disease ( CHD ) and cardiovascular disease ( CVD ) .
Effects of products made from a high-palmitic acid, trans-free semiliquid fat or a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile and on C-reactive protein concentrations in humans
Background : Many studies have shown that trans fatty acids have unfavorable effects on the serum lipoprotein profile . In general , however , fats were compared with different functional characteristics , which lower the practical applications of the results . Objective : The major aim of this study was to compare the effects of a high-palmitic acid , trans-free semiliquid fat with those of a high-oleic acid , low-trans semiliquid fat on the serum lipoprotein profile of healthy subjects . Subjects and design : Forty-four subjects ( 33 women and 11 men ) consumed , in r and om order , two experimental diets , each for 3 weeks . Diets provided 40 energy percent ( En% ) from fat , while 15 En% was supplied by the experimental fats . At the end of each intervention period , concentrations of serum lipoproteins , C-reactive protein , glucose and insulin were measured . Results : When subjects consumed the high-oleic acid , low-trans semiliquid fat , intakes of stearic acid ( + 1.3 En% ) , oleic acid ( + 2.9 En% ) , α-linolenic acid ( + 0.1 En% ) and trans fatty acids ( + 0.6 En% ) were higher and that of palmitic acid ( −4.2 En% ) lower . Serum concentration of low-density lipoprotein cholesterol decreased by 0.34±0.39 mmol/l ( mean±s.d . ; 95 % confidence interval ( CI ) , −0.46 to −0.23 mmol/l ; P<0.001 ) and high-density lipoprotein ( HDL ) cholesterol by −0.06±0.17 mmol/l ( 95 % CI , −0.11 to −0.01 mmol/l ; P=0.021 ) . Also , the total to HDL cholesterol ratio was lower ( −0.15±0.34 ; 95 % CI , −0.25 to −0.05 ; P=0.006 ) . Other parameters did not change . Conclusions : A high-oleic acid , low-trans semiliquid fat has a more favorable effect on the serum lipoprotein profile than a trans-free semiliquid fat with comparable functional characteristics , but high in palmitic acid
Comparison of PO diets with diets rich in stearic acid , monounsaturated fatty acids ( MUFAs ) , and polyunsaturated fatty acids ( PUFAs ) showed significantly higher TC , LDL cholesterol , apolipoprotein B , HDL cholesterol , and apolipoprotein A-I , whereas most of the same biomarkers were significantly lower when compared with diets rich in myristic/lauric acid .
Comparison of PO-rich diets with diets rich in trans fatty acids showed significantly higher concentrations of HDL cholesterol and apolipoprotein A-I and significantly lower apolipoprotein B , triacylglycerols , and TC/HDL cholesterol .
Stratified and meta-regression analyses showed that the higher concentrations of TC and LDL cholesterol , when PO was substituted for MUFAs and PUFAs , were not significant in young people and in subjects with diets with a lower percentage of energy from fat .
Both favorable and unfavorable changes in CHD/CVD risk markers occurred when PO was substituted for the primary dietary fats , whereas only favorable changes occurred when PO was substituted for trans fatty acids .
BACKGROUND Palm oil ( PO ) may be an unhealthy fat because of its high saturated fatty acid content .
OBJECTIVE The objective was to assess the effect of substituting PO for other primary dietary fats on blood lipid-related markers of coronary heart disease ( CHD ) and cardiovascular disease ( CVD ) .