This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
The effects of calcitriol on albuminuria in patients with type-2 diabetes mellitus.
The renin-angiotensin system has a major role in the development of diabetic nephropathy ( DN ) . It is reported that vitamin D analogues are able to suppress renin excretion . Thus , this study was conducted to determine whether there is any correlation between albuminuria as a marker of DN with vitamin D levels in diabetic patients . Also , an assessment was made on the effects of vitamin D therapy on albuminuria in this group of patients . We conducted this cross-sectional study on 119 out patients with type-2 diabetes . The serum levels of 25-hydroxy vitamin D [ 25 ( OH ) D ] and the albumin to creatinine ratio were assessed in all the study patients . Patients with vitamin D deficiency/insufficiency received calcitriol therapy for eight weeks , following which the laboratory tests were repeated . The mean age of the study patients was 55.3 ± 11.2 years , 43 ( 36.13 % ) had vitamin D insufficiency [ 25 ( OH ) D < 25 ng/mL ] and 31 ( 26.1 % ) had vitamin D deficiency [ 25 ( OH ) D < 15 ng/mL ] . We found a significant correlation between 25 ( OH ) D levels and presence of microalbuminuria ( P = 0.04 ) in patients with vitamin D deficiency . Therapy with calcitriol had a beneficial effect on the albumin excretion rate , although this change was not significant ( P = 0.22 ) . However , the effects of calcitriol on reduction of diastolic blood pressure ( P = 0.004 ) , glycosylated hemoglobin ( P = 0.014 ) and levels of total cholesterol ( P = 0.019 ) , low-density lipoprotein ( 0.04 ) and high-density lipoprotein ( P = 0.001 ) was significant . Our study suggests that vitamin D deficiency has a negative effect on albuminuria in diabetic patients , and its replacement may be associated with a beneficial effect on the risk factors of DN , such as hyperlipidemia and hypertension
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .