In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .
Prognostic factors in inflammatory breast cancer and therapeutic implications.
223 inflammatory breast cancer patients were diagnosed at the Institut Curie between 1977 and 1987 . Patients received chemotherapy and radiation treatment according to three consecutive r and omised trials . Five- and 10- year survival rates were 41 and 32 % , respectively . Disease-free interval rates were 25.5 % at 5 years and 19 % at 10 years . Parameters significantly linked with a pejorative prognosis in a multivariate analysis were : diffuse erythema , lymph node involvement , chest wall adherence , and age above 50 years . When therapeutic response parameters were included in the multivariate analysis , the five most important prognostic factors in order of significance were complete tumour regression after completion of induction treatment ( at 8 months ) , complete regression of inflammatory symptoms after 3 months of neoadjuvant chemotherapy , limited erythema at presentation and , less significantly , complete regression of inflammatory symptoms at 8 months and tumour regression at 3 months . In conclusion , patients who achieved a rapid and complete remission had a better prognosis than patients who had an incomplete response to chemotherapy . High-dose chemotherapy and reversal or prevention of drug resistance will be evaluated in future trials . Detailed information on the biology of this disease should allow the design of new strategies aim ing to improve patient management
In patients with a de novo diagnosis of breast cancer with synchronous distant metastases , surgery and radiotherapy result in considerably better locoregional tumor control .
An improvement in survival has not been consistently proven , but may exist in subgroups of patients .
Bei Patientinnen mit primärer Fernmetastasierung führt die lokale Beh and lung mittels Operation und/oder Strahlentherapie zur besseren lokalen Tumorkontrolle .
Aim The purpose of this work is to give practical guidelines for radiotherapy of locally advanced , inflammatory and metastatic breast cancer at first presentation .
ZusammenfassungZielZiel der Arbeit ist die Entwicklung von Praxis-Leitlinien zur Strahlentherapie des lokal fortgeschrittenen einschließlich des inflammatorischen Mammakarzinoms sowie zur lokalen Therapie bei synchroner Fernmetastasierung .
Ein Überlebensvorteil besteht wohl nicht , möglicherweise aber doch für einige Subgruppen der Patientinnen .