There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .
Intravenous versus oral iron supplementation for preoperative stimulation of hemoglobin synthesis using recombinant human erythropoietin.
To compare two modalities of iron supplementation for the preoperative stimulation of erythropoiesis using recombinant human erythropoietin ( rhEPO ) , 12 adults in normal hemoglobin and iron status due for elective surgery were r and omized to rhEPO 200 U/kg body weight subcutaneously twice weekly combined with either iron sucrose 200 mg intravenously twice weekly or iron sulfate 160 mg/day orally , for 3 weeks preoperatively . Efficacy was measured by the increases over baseline in hemoglobin , reticulocyte count , and ferritin determined 3 days before surgery ; preoperative reticulocyte count and ferritin were significantly higher with intravenous iron , whereas the only significant intragroup increases in hemoglobin between time points also occurred in this group . Intravenous iron significantly boosts the hematopoietic response to rhEPO and prevents iatrogenic iron depletion in otherwise healthy c and i date s for elective surgery
There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .