Specific recommendations for implantation of each prosthesis , taking into consideration the presence of pre-existent conduction abnormalities and anatomical factors , may be needed to reduce the risk of PPI
Aims The incidence of new-onset conduction abnormalities requiring permanent pacemaker implantation ( PPI ) after transcatheter aortic valve implantation ( TAVI ) with new-generation prostheses remains debated .
This systematic review analyses the incidence of PPI after TAVI  with new-generation devices and evaluates the electrical , anatomical , and procedural factors associated with PPI .
In addition , the incidence of PPI after  TAVI with early generation prostheses was review ed for comparison .
A multicentre European registry to evaluate the Direct Flow Medical transcatheter aortic valve system for the treatment of patients with severe aortic stenosis.
AIMS Our aim was to assess the clinical outcomes of the Direct Flow Medical Transcatheter Aortic Valve System ( DFM-TAVS ) , when used in routine clinical practice . METHODS AND RESULTS This is a prospect i ve , open-label , multicentre , post-market registry of patients treated with DFM-TAVS according to approved commercial indications . Echocardiographic and angiographic data were evaluated by an independent core laboratory and adverse events were adjudicated and classified according to VARC-2 criteria by an independent clinical events committee . The primary endpoint was freedom from all-cause mortality at 30 days post procedure . Secondary endpoints included procedural , early safety and efficacy endpoints at 30 days . Two hundred and fifty patients with severe aortic stenosis undergoing transcatheter aortic valve implantation ( TAVI ) with the DFM-TAVS were enrolled in 21 European centres . The primary endpoint , freedom from all-cause mortality at 30 days , was met in 98 % ( 245/250 ) of patients . Device success was 83.8 % . Moderate or severe aortic regurgitation was reported in 3 % of patients , and none/trace regurgitation in 73 % of patients . Post-procedural permanent pacemaker implantation was performed in 30 patients ( 12.0 % ) . CONCLUSIONS The DFM-TAVS was associated with good short-term outcomes in this real-world registry . The low pacemaker and aortic regurgitation rates confirm the advantages of this next-generation transcatheter heart valve ( THV )
Specific recommendations for implantation of each prosthesis , taking into consideration the presence of pre-existent conduction abnormalities and anatomical factors , may be needed to reduce the risk of PPI
Aims The incidence of new-onset conduction abnormalities requiring permanent pacemaker implantation ( PPI ) after transcatheter aortic valve implantation ( TAVI ) with new-generation prostheses remains debated .
This systematic review analyses the incidence of PPI after TAVI  with new-generation devices and evaluates the electrical , anatomical , and procedural factors associated with PPI .
In addition , the incidence of PPI after  TAVI with early generation prostheses was review ed for comparison .