Conclusions Our meta- analysis indicates that vitamin C may prevent post-operative atrial fibrillation in some countries outside of the USA , and it may also shorten the duration of hospital stay and ICU stay of cardiac surgery patients .
Vitamin C is an essential nutrient that is safe and inexpensive .
Background Atrial fibrillation ( AF ) , a common arrhythmia contributing substantially to cardiac morbidity , is associated with oxidative stress and , being an antioxidant , vitamin C might influence it .
The effect of intravenous vitamin C infusion on periprocedural myocardial injury for patients undergoing elective percutaneous coronary intervention.
BACKGROUND This small study has determined the effect of vitamin C on myocardial reperfusion in patients undergoing elective percutaneous coronary intervention ( PCI ) . This study was to explore whether antioxidant vitamin C infusion before the procedure is able to affect the incidence of periprocedural myocardial injury ( PMI ) in patients undergoing PCI . METHODS In this prospect i ve single-centre r and omized study , 532 patients were r and omized into 2 groups : the vitamin C group , which received a 3-g vitamin C infusion within 6 hours before PCI , and a control group , which received normal saline . The primary end point was the troponin I-defined PMI , and the second end point was the creatine kinase (CK)-MB-defined PMI . Separate analyses using both end points were performed . PMI was defined as an elevation of cardiac biomarker values ( CK-MB or troponin I ) > 5 times the upper limit of normal ( ULN ) , alone or associated with chest pain or ST-segment or T-wave changes . RESULTS After PCI , the incidence of PMI was reduced , whether defined by troponin or by CK-MB , compared with the control group ( troponin I , 10.9 % vs 18.4 % ; P = 0.016 ; CK-MB , 4.2 % vs 8.6 % ; P = 0.035 ) . Logistic multivariate analysis showed that preprocedure use of vitamin C is an independent predictor of PMI either defined by troponin I ( odds ratio [ OR ] , 0.56 ; 95 % confidence interval [ CI ] , 0.33 - 0.97 ; P = 0.037 ) or by CK-MB ( OR , 0.37 ; 95 % CI , 0.14 - 0.99 ; P = 0.048 ) . CONCLUSIONS In patients undergoing elective PCI , preprocedure intravenous treatment with vitamin C is associated with less myocardial injury
Conclusions Our meta- analysis indicates that vitamin C may prevent post-operative atrial fibrillation in some countries outside of the USA , and it may also shorten the duration of hospital stay and ICU stay of cardiac surgery patients .
Vitamin C is an essential nutrient that is safe and inexpensive .
Background Atrial fibrillation ( AF ) , a common arrhythmia contributing substantially to cardiac morbidity , is associated with oxidative stress and , being an antioxidant , vitamin C might influence it .