Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effect of vitamin D on musculoskeletal pain and headache: A randomized, double-blind, placebo-controlled trial among adult ethnic minorities in Norway
Summary Vitamin D supplementation for 16 weeks did not reduce  musculoskeletal pain or headache in this r and omized , double‐blind , placebo‐controlled study among ethnic minorities living in Norway . ABSTRACT Immigrants from South Asia , the Middle East , and Africa living in Northern Europe frequently have low vitamin D levels and more pain compared to the native Western population . The aim of this study was to examine whether daily vitamin D3 ( 25 & mgr;g/d or 10 & mgr;g/d ) supplementation for 16 weeks would improve musculoskeletal pain or headache compared to placebo . This r and omized , double‐blind , placebo‐controlled , parallel‐group trial recruited 251 participants aged 18 to 50 years , and 215 ( 86 % ) attended the follow‐up visit .  The pain measures were occurrence , anatomical localization , and degree of musculoskeletal pain , as measured by visual analogue scale ( VAS ) score during the past 2 weeks . Headache was measured with VAS and the Headache Impact Test ( HIT‐6 ) question naire . At baseline , females reported more pain sites ( 4.7 ) than males ( 3.4 ) , and only 7 % reported no pain in the past 2 weeks . During the past 4 weeks , 63 % reported headache with a high mean HIT‐6 score of 60 ( SD 7 ) . At follow‐up , vitamin D level , measured as serum 25(OH)D3 , increased from 27 nmol/L to 52 nmol/L and from 27 nmol/L to 43 nmol/L in the 25‐&mgr;g and 10‐&mgr;g supplementation groups , respectively , whereas serum 25(OH)D3 did not change in the  placebo group . Pain scores and headache scores were improved at follow‐up compared with baseline . The use of vitamin D supplements , however , showed no significant effect on the occurrence , anatomical localization , and degree of pain or headache compared to placebo
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .