Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .
Extended antibiotic therapy versus placebo after laparoscopic cholecystectomy for mild and moderate acute calculous cholecystitis: A randomized double‐blind clinical trial☆
Background : Acute calculous cholecystitis ( ACC ) is the most common complication of cholelithiasis . Laparoscopic cholecystectomy ( LC ) is the gold st and ard treatment in mild and moderate forms . Currently there is consensus for the use of antibiotics in the preoperative phase of ACC . However , the need for antibiotic therapy after surgery remains undefined with a low level of scientific evidence . Methods : The CHART ( Cholecystectomy Antibiotic R and omised Trial ) study is a single‐center , prospect i ve , double blind , and r and omized trial . Patients with mild to moderate ACC operated by LC were r and omly assigned to receive antibiotic ( amoxicillin/clavulanic acid ) or placebo treatment for 5 consecutive days . The primary endpoint was postoperative infectious complications . Secondary endpoints were as follows : ( 1 ) duration of hospital stay , ( 2 ) readmissions , ( 3 ) reintervention , and ( 4 ) overall mortality . Results : In the per‐ protocol analysis , 6 of 104 patients ( 5.8 % ) in the placebo arm and 6 of 91 patients ( 6.6 % ) in the antibiotic arm developed postoperative infectious complications ( absolute difference 0.82 ( 95 % confidence interval , −5.96 to 7.61 , P = .81 ) . The median hospital stay was 3 days . There was no mortality . There were no differences regarding readmissions and reoperations between the 2 groups . Conclusion : Although this trial failed to show noninferiority of postoperative placebo compared to antibiotic treatment after LC for mild and moderate ACC within a noninferiority margin of 5 % , the use of antibiotics in the postoperative period does not seem justified , because it was not associated with a decrease in the incidence of infectious and other types of morbidity in the present study
Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .