When alprazolam was compared with placebo for reduction in symptoms all estimates indicated a positive effect for alprazolam .
The RD of all-cause withdrawals did not differ between alprazolam and placebo .
Alprazolam appears to reduce depressive symptoms more effectively than placebo and as effectively as tricyclic antidepressants .
Whilst the rate of all-cause withdrawals did not appear to differ between alprazolam and placebo , and withdrawals were less frequent in the alprazolam group than in any of the conventional antidepressants combined group , these findings should be interpreted with caution , given the dependency properties of benzodiazepines
BACKGROUND The ' off-label ' effect of alprazolam on depression has not been systematic ally evaluated .
OBJECTIVES To determine the antidepressant effect , including tolerability and acceptability , of alprazolam as monotherapy for major depression , when compared to placebo and conventional antidepressants in out patients and patients in primary care .
Differential response to chlorpromazine, imipramine, and placebo. A study of subgroups of hospitalized depressed patients.
A MAJOR aim of the present study was to examine the differential effects of chlorpromazine and imipramine among various depression subgroups . Tests were made of differential drug effects among Overall et al 's 1 three empirically derived depressive subtypes , ie , anxious , hostile , and withdrawn-retarded depressives . These investigators found a tranquilizer , thioridazine , best for their anxious depressives and imipramine best for the withdrawn-retarded depressives . An examination was also made of differential drug effects among psychotic depressives , neurotic depressives , and schizophrenics with depression . As there is a tendency in this country to equate psychotic depression with endogenous depression , study findings may have some relevance for the endogenous-neurotic distinction . Proponents of this distinction have reported that imipramine is especially efficacious for endogenous depression and of little value in neurotic depressions . 2 - 12 Finally , tests were made of differential drug effects among depressed patients categorized on the basis of sex and age ( below 40 and 40
When alprazolam was compared with placebo for reduction in symptoms all estimates indicated a positive effect for alprazolam .
The RD of all-cause withdrawals did not differ between alprazolam and placebo .
Alprazolam appears to reduce depressive symptoms more effectively than placebo and as effectively as tricyclic antidepressants .
Whilst the rate of all-cause withdrawals did not appear to differ between alprazolam and placebo , and withdrawals were less frequent in the alprazolam group than in any of the conventional antidepressants combined group , these findings should be interpreted with caution , given the dependency properties of benzodiazepines
BACKGROUND The ' off-label ' effect of alprazolam on depression has not been systematic ally evaluated .
OBJECTIVES To determine the antidepressant effect , including tolerability and acceptability , of alprazolam as monotherapy for major depression , when compared to placebo and conventional antidepressants in out patients and patients in primary care .