Vitamin D has a potentially significant role for improving the symptoms of AD .
The results from this study suggest that vitamin D supplementation may help ameliorate the severity of AD , and can be considered as a safe and tolerable therapy .
OBJECTIVES Despite the evidence supporting the use of vitamin D supplements for managing atopic dermatitis ( AD ) , no meta- analysis providing definite conclusions in this field has been reported .
The purpose of the present study was to conduct a systematic review and meta- analysis of all controlled studies of vitamin D for treating AD to eluci date the efficacy of vitamin D for alleviating the symptoms of AD .
A randomized controlled double-blind investigation of the effects of vitamin D dietary supplementation in subjects with atopic dermatitis.
BACKGROUND Subjects with atopic dermatitis ( AD ) have defects in antimicrobial peptide ( AMP ) production possibly contributing to an increased risk of infections . In laboratory models , vitamin D can alter innate immunity by increasing AMP production . OBJECTIVE To determine if AD severity correlates with baseline vitamin D levels , and to test whether supplementation with oral vitamin D alters AMP production in AD skin . METHODS This was a multi-centre , placebo-controlled , double-blind study in 30 subjects with AD , 30 non-atopic subjects , and 16 subjects with psoriasis . Subjects were r and omized to receive either 4000 IU of cholecalciferol or placebo for 21 days . At baseline and day 21 , levels of 25-hydroxyvitamin D ( 25OHD ) , cathelicidin , HBD-3 , IL-13 , and Eczema Area and Severity Index ( EASI ) and Rajka-Langel and scores were obtained . RESULTS At baseline , 20 % of AD subjects had serum 25OHD below 20 ng/mL. Low serum 25OHD correlated with increased Fitzpatrick Skin Type and elevated BMI , but not AD severity . After 21 days of oral cholecalciferol , mean serum 25OHD increased , but there was no significant change in skin cathelicidin , HBD-3 , IL-13 or EASI scores . CONCLUSIONS This study illustrated that darker skin types and elevated BMI are important risk factors for vitamin D deficiency in subjects with AD , and highlighted the possibility that seasonality and locale may be potent contributors to cathelicidin induction through their effect on steady state 25OHD levels . Given the molecular links between vitamin D and immune function , further study of vitamin D supplementation in subjects with AD is warranted
Vitamin D has a potentially significant role for improving the symptoms of AD .
The results from this study suggest that vitamin D supplementation may help ameliorate the severity of AD , and can be considered as a safe and tolerable therapy .
OBJECTIVES Despite the evidence supporting the use of vitamin D supplements for managing atopic dermatitis ( AD ) , no meta- analysis providing definite conclusions in this field has been reported .
The purpose of the present study was to conduct a systematic review and meta- analysis of all controlled studies of vitamin D for treating AD to eluci date the efficacy of vitamin D for alleviating the symptoms of AD .