RESULTS Following an extensive review of selected studies from the 201 articles , the studies indicate that each of the psychotropic medications review ed impact alpha , beta , delta and theta waves independently and differently from each other .
Additionally , certain medications , particularly haloperidol and valproic acid , have dissimilar results exemplified in all waveforms .
OBJECTIVES It is known that psychotropic medications have an impact on the readings found in Electroencephalogram ( EEG ) .
In the field of psychiatry , there are several psychotropics utilized by clinicians .
This review seeks to investigate all the available data for psychotropic drugs and their impact on EEG changes .
A comparison of the central nervous system effects of haloperidol, chlorpromazine and sulpiride in normal volunteers.
1 . Twelve healthy male volunteers participated in four experimental occasions during each of which they were dosed with one of the following anti-psychotic drugs : chlorpromazine ( 50 mg ) , haloperidol ( 3 mg ) , sulpiride ( 400 mg ) and placebo . Drugs were allocated to subjects in a double-blind , crossover fashion . 2 . The subject 's mood state , psychometric performance and electroencephalogram ( EEG ) were assessed pre-dose , and at 2 , 4 , 6 , 8 , 24 and 48 h post-dose . Mood states were assessed using 16 visual analogue scales and psychomotor performance was measured using the following tests : elapsed time estimation , tapping rate , choice reaction times , a rapid information processing task , flash fusion threshold , a manipulative motor task , digit span , body sway and tremor . 3 . Chlorpromazine and haloperidol significantly reduced subjective ratings of ' alertness ' and ' contentedness ' , and haloperidol significantly reduced feelings of ' calmness ' .  Sulpiride did not significantly affect any of the visual analogue scales . 4 . All three anti-psychotic drugs had similar EEG effects with peak effect 2 to 4 h postdose . The profile was characterised by an increase in the proportion of slow wave activity ( delta and theta ) as well as decreased alpha ( 8 - 14 Hz ) and faster ( beta ) wave activity . 5 . Chlorpromazine reduced tapping rate and increased choice reaction movement times . Haloperidol reduced the flash fusion threshold frequency at 6 h post-dose . Sulpiride prolonged the duration of the manipulative motor task , particularly at 48 h post-dose . 6 . All three anti-psychotic drugs impaired performance on the rapid information processing task . Chlorpromazine significantly reduced the number of correct letter pair identification s at 2 , 4 and 6 h post-dose , haloperidol at 4 , 6 , 8 , 24 and 48 h post-dose , and sulpiride at 24 h post-dose . ( ABSTRACT TRUNCATED AT 250 WORDS
RESULTS Following an extensive review of selected studies from the 201 articles , the studies indicate that each of the psychotropic medications review ed impact alpha , beta , delta and theta waves independently and differently from each other .
Additionally , certain medications , particularly haloperidol and valproic acid , have dissimilar results exemplified in all waveforms .
OBJECTIVES It is known that psychotropic medications have an impact on the readings found in Electroencephalogram ( EEG ) .
In the field of psychiatry , there are several psychotropics utilized by clinicians .
This review seeks to investigate all the available data for psychotropic drugs and their impact on EEG changes .