Conclusions No conclusive recommendations were possible due to wide variation in study quality , method ologies and outcome measures .
A synthesis of available literature suggests that treatments containing urea as a primary active ingredient have been the most research ed .
Background Xerosis , literally dryness of the skin , of the foot is a common condition encountered clinical ly , which can lead to discomfort and predisposition to infection .
Currently , there are no evidence -based recommendations on which moisturiser formulations best alleviate xerotic symptoms .
The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis , by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population .
Ammonium lactate 12% lotion versus a liposome-based moisturizing lotion for plantar xerosis. A double-blind comparison study.
Two emollients , ammonium lactate 12 % lotion and a liposome-based moisturizing lotion , were compared in a double-blind test for efficacy in the treatment of plantar xerosis . A total of 43 out of 57 participants ( 75 % ) with bilateral plantar xerosis followed instructions completely and applied the lotions ( one to each foot ) twice daily for 4 weeks . Each participant was evaluated once a week for 6 weeks ( the final 2 weeks for evaluation of post-treatment regression ) to determine xerotic grade ( degree of dryness ) and treatment effectiveness . With both lotions , significant improvement began during the second week of treatment and continued into the fourth week . There were no significant differences between the two lotions in the 6-week patterns of either xerotic grade or treatment effectiveness
Conclusions No conclusive recommendations were possible due to wide variation in study quality , method ologies and outcome measures .
A synthesis of available literature suggests that treatments containing urea as a primary active ingredient have been the most research ed .
Background Xerosis , literally dryness of the skin , of the foot is a common condition encountered clinical ly , which can lead to discomfort and predisposition to infection .
Currently , there are no evidence -based recommendations on which moisturiser formulations best alleviate xerotic symptoms .
The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis , by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population .