Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .
Lipoprotein(a) as a risk factor for cardiovascular mortality in type 2 diabetic patients: a 10-year follow-up study.
Although patients with type 2 diabetes have a high risk of death from cardiovascular disease ( CVD ) , the traditional risk factors do not fully explain this excess of mortality . In this regard , it would be of great interest to assess the role of nontraditional risk factors such as lipoprotein(a ) in cardiovascular mortality in diabetic patients . Danesh et al. ( 1 ) , in a meta- analysis including the prospect i ve studies published before 2000 , concluded that there was a clear association between lipoprotein(a ) and CVD in the general population . Further prospect i ve reports have demonstrated that lipoprotein(a ) is an independent predictor of the development of CVD ( 2–5 ) . However , little data exist on the clinical importance of lipoprotein(a ) in the diabetic population . We herein report a prospect i ve study to evaluate the relationship between lipoprotein(a ) levels and cardiovascular mortality in type 2 diabetic patients of Caucasian origin . One hundred twenty-two consecutive type 2 diabetic out patients of Caucasian origin attending the outpatient diabetic unit of a university hospital between April and May of 1993 were enrolled for a 10-year prospect i ve study . To avoid the possible transient increase of lipoprotein(a ) after starting insulin treatment ( 6 ) , all patients in whom insulin treatment was initiated in the months before the study were excluded . Patients with renal failure were also excluded . To assess evidence of macroangiopathy , we used the World Health Organization ( WHO ) protocol , which includes a detailed question naire and a 12-lead electrocardiogram ( 7,8 ) . By the end of the study , data were available from 100 patients . Of these , 29 had died ( 23 from CVD ) . Metabolic parameters
Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .