The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels
Background A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D ( 25OHD ) levels on non-skeletal outcomes .
We performed a systematic quantitative review on characteristics of r and omized clinical trials ( RCTs ) included in meta-analyses ( MAs ) on non-skeletal effects of vitamin D supplementation .
The effect of vitamin D supplementation on blood pressure in patients with elevated blood pressure and vitamin D deficiency: a randomized, double-blind, placebo-controlled trial
Objectives The present evidence indicates a reverse correlation between vitamin D status and blood pressure ( BP ) . The present study determined the effect of oral vitamin D supplementation on BP in patients with elevated BP and vitamin D deficiency . Material s and methods In this r and omized , double-blind , placebo-controlled trial , 42 out patients with elevated BP and vitamin D deficiency were assigned r and omly to two groups : the vitamin D-supplemented group ( VDG ) , who received one capsule containing 50 000 IU of cholecalciferol weekly , and the placebo group ( PG ) , who received one similar capsule containing oral liquid paraffin as placebo for 8 weeks . The systolic ( SBP ) and diastolic ( DBP ) blood pressures , mean arterial blood pressure ( MAP ) , pulse pressure , serum 25-hydroxyvitamin D , parathormone , calcium , phosphorus , magnesium , sodium , and potassium were measured before and after the intervention . Results In all , 92.7 % of the VDG recovered from vitamin D deficiency . At the end of the intervention , the mean SBP and DBP , and the MAP decreased significantly in VDG compared with the PG , whereas at the beginning of the intervention , there was no significant difference between the two groups . The mean changes in SBP ( −6.4±5.3 vs. 0.9±3.7 mmHg , PV<0.001 ) , DBP ( −2.4±3.7 vs. 1.0±2.7 mmHg , PV=0.003 ) , and MAP ( −3.7±3.6 vs. 0.9±2.5 mmHg , PV<0.001 ) were lower in the VDG than PG . Conclusion The findings of the study showed that the weekly administration of 50 000 IU of oral vitamin D for 8 weeks as an adjunct supplement of antihypertensive drugs in patients with vitamin D deficiency could help prevent vitamin D deficiency and aid control of SBP , DBP , and MAP
The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels
Background A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D ( 25OHD ) levels on non-skeletal outcomes .
We performed a systematic quantitative review on characteristics of r and omized clinical trials ( RCTs ) included in meta-analyses ( MAs ) on non-skeletal effects of vitamin D supplementation .