Conclusions Exercise-based cardiac rehabilitation is effective at reducing important clinical outcomes in patients with coronary heart disease .
While our analysis was constrained by the quality of included trials and missing information about intervention components , there appears to be little differential effect of variations in exercise intervention , particularly on mortality outcomes .
Background While the clinical benefits of exercise-based cardiac rehabilitation are well established , there is extensive variation in the interventions used within these trials .
It is unknown whether variations in individual components of these exercise interventions provide different relative contributions to overall clinical outcomes .
This study aims to systematic ally examine the relationship between individual components of the exercise intervention in cardiac rehabilitation ( such as intensity and frequency ) and clinical outcomes for people with coronary heart disease .
Left ventricular remodelling in patients with moderate systolic dysfunction after myocardial infarction: favourable effects of exercise training and predictive role of N-terminal pro-brain natriuretic peptide
Aims To investigate the effects of exercise training ( ET ) on left ventricular ( LV ) volumes , cardiopulmonary functional capacity and N-terminal pro-brain natriuretic peptide ( NT-proBNP ) levels in postinfa rct ion patients with moderate LV dysfunction . Methods Sixty-one postinfa rct ion patients were r and omized into two groups : group T [ n = 30 , LV ejection fraction ( EF ) 41.6 ± 11.3 % , mean ± SD ] entered a 6-month ET programme , whereas group C ( n = 31 , EF 42.0 ± 7.6 % , P = NS ) did not . NT-proBNP assay , Doppler-echocardiography and cardiopulmonary exercise test  were performed upon enrolment and at sixth months . Results At sixth months , trained patients showed an improvement in workload ( + 26 % , P<0.001 ) , Vo2peak ( + 31 % , P<0.001 ) , LV end-diastolic volume index ( LVEDVI ; −9 % , P<0.001 ) , a reduction in NT-proBNP ( −71 % , P<0.001 ) and a significant correlation between changes in NT-proBNP and in LVEDVI ( r=0.858 , P<0.001 ) . Baseline NT-proBNP correlated with changes in LVEDVI in both trained ( r=0.673 , P<0.001 ) and untrained ( r=0.623 , P<0.001 ) patients . Group C showed unfavourable LVEDVI dilation ( + 8 % , P<0.001 ; T vs. C group , P<0.001 ) and a smaller reduction in NT-proBNP ( −40 % , P<0.001 ; T vs. C group , P<0.001 ) . Conclusions Six month ET induced a favourable LV remodelling and a marked fall in NT-proBNP that could predict LV remodelling in postinfa rct ion patients with moderate LV dysfunction
Conclusions Exercise-based cardiac rehabilitation is effective at reducing important clinical outcomes in patients with coronary heart disease .
While our analysis was constrained by the quality of included trials and missing information about intervention components , there appears to be little differential effect of variations in exercise intervention , particularly on mortality outcomes .
Background While the clinical benefits of exercise-based cardiac rehabilitation are well established , there is extensive variation in the interventions used within these trials .
It is unknown whether variations in individual components of these exercise interventions provide different relative contributions to overall clinical outcomes .
This study aims to systematic ally examine the relationship between individual components of the exercise intervention in cardiac rehabilitation ( such as intensity and frequency ) and clinical outcomes for people with coronary heart disease .