The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels
Background A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D ( 25OHD ) levels on non-skeletal outcomes .
We performed a systematic quantitative review on characteristics of r and omized clinical trials ( RCTs ) included in meta-analyses ( MAs ) on non-skeletal effects of vitamin D supplementation .
Effects of Vitamin D Supplementation on Plasma Aldosterone and Renin-A Randomized Placebo-Controlled Trial.
Increasing evidence describes a possible interplay between vitamin D insufficiency with increased aldosterone . The authors sought to evaluate the effect of vitamin D supplementation on plasma aldosterone concentration ( PAC ) in patients with hypertension and 25-hydroxyvitamin D[25(OH)D ] insufficiency . The Styrian Vitamin D Hypertension Trial was a single-center , double-blind , placebo-controlled r and omized clinical trial conducted from 2011 to 2014 . Two hundred patients with arterial hypertension and 25(OH)D levels < 30 ng/mL were enrolled . Study participants were r and omized to receive either 2800 IU of vitamin D3 or placebo . The present investigation is a post hoc analysis using analysis of covariance adjusting for baseline differences . A total of 188 participants ( mean±st and ard deviation age , 60.1±11.3 years ; 47 % women ; 25(OH)D , 21.2±5.6 ng/mL ) completed the trial . Mean differences between baseline and follow-up PAC in the control and intervention arm were + 3.3 ng/dL and + 0.9 ng/dL , respectively ( P=.04 ) . The findings indicate that vitamin D3 supplementation  significantly decreases PAC in patients with arterial hypertension and 25(OH)D insufficiency
The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels
Background A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D ( 25OHD ) levels on non-skeletal outcomes .
We performed a systematic quantitative review on characteristics of r and omized clinical trials ( RCTs ) included in meta-analyses ( MAs ) on non-skeletal effects of vitamin D supplementation .