The 2014 guideline has been up date d by a multidisciplinary panel using the highest method ological st and ards , and provides the best and most reliable contemporary evidence base for RCC management .
CONTEXT The European Association of Urology Guideline Panel for Renal Cell Carcinoma ( RCC ) has prepared evidence -based guidelines and recommendations for RCC management .
OBJECTIVES To provide an up date of the 2010 RCC guideline based on a st and ardised methodology that is robust , transparent , reproducible , and reliable .
Improved prognostication of renal cell carcinoma using an integrated staging system.
PURPOSE To integrate stage , grade , and Eastern Cooperative Oncology Group ( ECOG ) performance status ( PS ) into a clinical ly useful tool capable of stratifying the survival of renal cell carcinoma ( RCC ) patients . PATIENTS AND METHODS The medical records of 661 patients undergoing nephrectomy at University of California Los Angeles between 1989 and 1999 were evaluated . Median age was 61 years , male-to-female ratio was 2.2:1 , and median follow-up was 37 months .  Survival time was the primary end point assessed . Sixty-four possible combinations of stage , grade , and ECOG PS were analyzed and collapsed into distinct groups . The internal validity of the categorized was challenged by a univariate analysis and a multivariate analysis testing for the accountability of each UCLA Integrated Staging System ( UISS ) category against independent variables shown to have impact on survival . RESULTS Combining and stratifying 1997 tumor-node-metastasis stage , Fuhrman 's grade and ECOG PS result ed in five survival stratification groups design ated UISS , and numbered I to V. The projected 2- and 5-year survival for the UISS groups are as follows for the groups : I , 96 % and 94 % ; II , 89 % and 67 % ; III , 66 % and 39 % ; IV , 42 % and 23 % ; and V , 9 % and 0 % , respectively . UISS accounted for the significant variables in the variate analysis . CONCLUSION A novel system for staging and predicting survival for RCC integrating clinical variables is offered . UISS is simple to use and is superior to stage alone in differentiating patients ' survival . Our data suggests that UISS is an important prognostic tool for counseling patients with various stages of kidney cancer . Further prospect i ve large-scale validation with external data is awaited
The 2014 guideline has been up date d by a multidisciplinary panel using the highest method ological st and ards , and provides the best and most reliable contemporary evidence base for RCC management .
CONTEXT The European Association of Urology Guideline Panel for Renal Cell Carcinoma ( RCC ) has prepared evidence -based guidelines and recommendations for RCC management .
OBJECTIVES To provide an up date of the 2010 RCC guideline based on a st and ardised methodology that is robust , transparent , reproducible , and reliable .