There were no statistically significant differences in mortality , infections overall and adverse events .
Perioperative antibiotic prophylaxis of ≥24 hours may be more efficacious in preventing sternal SSIs in patients undergoing cardiac surgery compared to shorter regimens .
OBJECTIVE We aim ed to compare the efficacy of short-term ( < 24 hours ) versus longer-term antibiotic prophylaxis ( ≥24 hours ) in open heart surgery .
BACKGROUND The optimal duration of antibiotic prophylaxis for adults undergoing cardiac surgery is unknown and guideline recommendations are inconsistent .
Ceftriaxone vs cefuroxime for infection prophylaxis in coronary bypass surgery.
The most serious infection after coronary artery bypass grafting ( CABG ) is mediastinitis following deep sternal wound infection . Antibiotic prophylaxis for at least 48 hours has been recommended . In this trial 551 consecutive patients were r and omized to receive ceftriaxone in a single dose or cefuroxime thrice daily until the end of the second postoperative day . The overall infection rate was 7.7 % in the ceftriaxone and 8.3 % in the cefuroxime group , and the incidence of deep sternal infection was 2.9 % in both groups . Significant risk factors for such infection were chronic respiratory disease ( p < 0.001 ) and diabetes ( p < 0.01 ) . The antibiotic prophylaxis had no harmful effects on the colonic flora in either group . Acquisition and delivery costs for the prophylactic agents were three times higher in the cefuroxime than in the ceftriaxone group . Both antibiotics are concluded to be equally safe and effective . Single-dose ceftriaxone prophylaxis is as effective as cefuroxime given for 48 hours postoperatively . Single-dose ceftriaxone is also simple to use
There were no statistically significant differences in mortality , infections overall and adverse events .
Perioperative antibiotic prophylaxis of ≥24 hours may be more efficacious in preventing sternal SSIs in patients undergoing cardiac surgery compared to shorter regimens .
OBJECTIVE We aim ed to compare the efficacy of short-term ( < 24 hours ) versus longer-term antibiotic prophylaxis ( ≥24 hours ) in open heart surgery .
BACKGROUND The optimal duration of antibiotic prophylaxis for adults undergoing cardiac surgery is unknown and guideline recommendations are inconsistent .