Pelvic floor exercises are more effective in subjective and objective outcomes with biofeedback or verbal feedback .
Weight loss with diet and exercise , caffeine reduction , 25 - 50 % reduction in fluid intake , and pelvic floor muscle exercises with verbal instruction and or biofeedback were all efficacious .
Botulinum toxin A improves urge incontinence episodes , urgency , frequency , quality of life , nocturia , and urodynamic testing parameters .
Acupuncture  improves quality of life and urodynamic testing parameters .
Extracorporeal magnetic stimulation improves urodynamic parameters .
Mirabegron improves daily incontinence episodes , nocturia , number of daily voids , and urine volume per void , whereas solabegron improves daily incontinence episodes .
Short-term posterior tibial nerve stimulation is more efficacious than pelvic floor muscle training exercises and behavioral therapy for improving : urgency , urinary incontinence episodes , daily voids , volume per void , and overall quality of life .
Sacral neuromodulation is more efficacious than antimuscarinic treatment for subjective improvement of overactive bladder and quality of life .
Transvaginal electrical stimulation demonstrates subjective improvement in overactive bladder symptoms and urodynamic parameters .
Multiple therapies , including physical therapy , behavioral therapy , botulinum toxin A , acupuncture , magnetic stimulation , mirabegron , posterior tibial nerve stimulation , sacral neuromodulation , and transvaginal electrical stimulation , are efficacious in the treatment of overactive bladder
The purpose of the study was to determine the efficacy and safety of nonantimuscarinic treatments for overactive bladder .
Sacral neuromodulation in the treatment of urgency-frequency symptoms: a multicenter study on efficacy and safety.
PURPOSE Neuromodulation of sacral nerves has shown promising results in correcting  voiding dysfunction .  We report the results of a multicenter trial design ed to assess the efficacy of sacral nerve neuromodulation in patients presenting with refractory urinary urgency-frequency . MATERIAL S AND METHODS A total of 51 patients from 12 centers underwent baseline assessment , including a detailed voiding diary , urodynamic evaluation and percutaneous test stimulation of the sacral nerves at S3 and /or S4 . All patients enrolled in the study had undergone prior conventional treatment , such as pharmacotherapy , hydrodistention and surgical intervention , which failed . All patients demonstrated a satisfactory response to trial stimulation and were r and omly divided into a stimulation group ( 25 patients ) and a control group ( 26 ) . A sacral nerve stimulation device was implanted after 6 months in the control group . Patients were followed at 1 , 3 and 6 months , and at 6-month intervals for up to 2 years after implantation of a neuroprosthetic InterStim * system . dagger The study variables included the number of voids daily , volume voided per void and degree of urgency before void . RESULTS Compared to the control group , 6-month voiding diary results demonstrated statistically significant improvements ( p < 0.0001 ) in the stimulation group with respect to the number voids daily ( 16.9 + /- 9.7 to 9.3 + /- 5.1 ) , volume per void ( 118 + /- 74 to 226 + /- 124 ml . ) and degree of urgency ( rank 2.2 + /- 0.6 to 1.6 + /- 0.9 ) . Patients in the control group showed no significant changes in voiding parameters at 6 months . Significant improvements in favor of the stimulation group were noted in various parameters with respect to water cystometry and quality of life ( SF-36 ) . At 6 months after implant , neurostimulators were turned off in the stimulation group and urinary symptoms returned to baseline values . After reactivation of stimulation sustained efficacy was documented at 12 and 24 months . CONCLUSIONS Neuromodulation of the sacral nerves is an effective , safe therapy that successfully treats significant symptoms of refractory urgency-frequency
Pelvic floor exercises are more effective in subjective and objective outcomes with biofeedback or verbal feedback .
Weight loss with diet and exercise , caffeine reduction , 25 - 50 % reduction in fluid intake , and pelvic floor muscle exercises with verbal instruction and or biofeedback were all efficacious .
Botulinum toxin A improves urge incontinence episodes , urgency , frequency , quality of life , nocturia , and urodynamic testing parameters .
Acupuncture  improves quality of life and urodynamic testing parameters .
Extracorporeal magnetic stimulation improves urodynamic parameters .
Mirabegron improves daily incontinence episodes , nocturia , number of daily voids , and urine volume per void , whereas solabegron improves daily incontinence episodes .
Short-term posterior tibial nerve stimulation is more efficacious than pelvic floor muscle training exercises and behavioral therapy for improving : urgency , urinary incontinence episodes , daily voids , volume per void , and overall quality of life .
Sacral neuromodulation is more efficacious than antimuscarinic treatment for subjective improvement of overactive bladder and quality of life .
Transvaginal electrical stimulation demonstrates subjective improvement in overactive bladder symptoms and urodynamic parameters .
Multiple therapies , including physical therapy , behavioral therapy , botulinum toxin A , acupuncture , magnetic stimulation , mirabegron , posterior tibial nerve stimulation , sacral neuromodulation , and transvaginal electrical stimulation , are efficacious in the treatment of overactive bladder
The purpose of the study was to determine the efficacy and safety of nonantimuscarinic treatments for overactive bladder .