While no clinical trial to date has specifically targeted fatigue , r and omized controlled trials , systematic review s , and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue .
Fatigue is a disabling , multifaceted symptom that is highly prevalent and stubbornly persistent .
Although fatigue is a frequent complaint among patients with fibromyalgia , it has not received the same attention as pain .
Reasons for this include lack of st and ardized nomenclature to communicate about fatigue , lack of evidence -based guidelines for fatigue assessment , and a deficiency in effective treatment strategies .
Fatigue does not occur in isolation ; rather , it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain , unrefreshing sleep , anxiety , depression , cognitive difficulties , and so on .
Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms .
Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation.
S-adenosylmethionine is a relatively new anti-inflammatory drug with analgesic and anti-depressant effects . Efficacy of 800 mg orally administered s-adenosylmethionine daily versus placebo for six weeks was investigated in 44 patients with primary fibromyalgia in double-blind setting s. Tender point score , isokinetic muscle strength , disease activity , subjective symptoms ( visual analog scale ) , mood parameters and side effects were evaluated . Improvements were seen for clinical disease activity ( P = 0.04 ) , pain experienced during the last week ( P = 0.002 ) , fatigue ( P = 0.02 ) , morning stiffness ( P = 0.03 ) and mood evaluated by Face Scale ( P = 0.006 ) in the actively treated group compared to placebo . The tender point score , isokinetic muscle strength , mood evaluated by Beck Depression Inventory and side effects did not differ in the two treatment groups . S-adenosylmethionine has some beneficial effects on primary fibromyalgia and could be an important option in the treatment hereof
While no clinical trial to date has specifically targeted fatigue , r and omized controlled trials , systematic review s , and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue .
Fatigue is a disabling , multifaceted symptom that is highly prevalent and stubbornly persistent .
Although fatigue is a frequent complaint among patients with fibromyalgia , it has not received the same attention as pain .
Reasons for this include lack of st and ardized nomenclature to communicate about fatigue , lack of evidence -based guidelines for fatigue assessment , and a deficiency in effective treatment strategies .
Fatigue does not occur in isolation ; rather , it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain , unrefreshing sleep , anxiety , depression , cognitive difficulties , and so on .
Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms .