Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .
Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people.
INTRODUCTION Conjugated linoleic acids ( CLAs ) have shown beneficial effects in weight control therapy however this relation is not clear . OBJETIVE The aim of the study was to examine the effects and safety of 3 g of a 1:1 mix of c9-t11 and t10-c12 on weight control and body composition in healthy overweight individuals . METHODS A prospect i ve , placebo-controlled , r and omised double-blind , parallel clinical trial lasting 24 weeks was carried out in 38 volunteers ( 29w , 9 m ) aged 30 - 55 years and BMI ≥27-<30 kg/m2 who consumed 200 ml/day of skimmed milk with 3 g of CLAs or 3 g olive oil ( placebo ) .  Anthropometric , biochemical and dual x-ray absorptiometry ( DXA ) tests were measured . Diet and physical activity were assessed . RESULTS Subjects maintained their habitual dietary and exercise patterns over the study . Only CLA group showed a significant decrease in weight ( 74.43 ± 10.45 vs 73.54 ± 11.66 kg , p = 0.029 ) and waist circumference ( 91.45 ± 10.33 vs 90.65 ± 9.84 cm , p = 0.012 ) between baseline and end of the study . BMI and waist height ratio decreased ( 28.44 ± 1.08 vs 27.81 ± 1.43 kg/m2 , p = 0.030 and 0.57 ± 0.05 vs 0.56 ± 0.04 p = 0.013 respectively ) in CLA group at the end . CLA group experienced a reduction in total fat mass after 24 weeks ( 38.62 ± 5.02 vs 36.65 ± 5.64 % , p = 0.035 ) . No decrease was observed in Control group . HOMA index had no changes . CONCLUSIONS The consumption of skimmed milk enriched with 3 g of a 1:1 mixture of c9-t11 and t10-c12 for 24 weeks led to a decrease in body weight and total fat mass in healthy , overweight subjects who maintained habitual diets and exercise patterns . No adverse effects were observed . Registered under Clinical Trials.gov Identifier No. NCT01503047
Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .