Moreover , subgroup analyses suggested that the effects of glycemic control were significantly influenced by the sex of the subjects and the type and the method of intake of ITF .
Conclusions Our analyses confirmed that these four main glycemic indicators were significantly reduced by ITF supplementation , particularly in the prediabetes and T2DM population .
Evidence supports that reasonable administration of ITF supplementation may have potential clinical value as an adjuvant therapy for prediabetes and T2DM management .
Background Currently , many clinical trials have shown that inulin-type fructans ( ITF ) supplementation is associated with glycemic control ; nevertheless , the results are inconclusive .
The aim of this meta- analysis of r and omized controlled trials was to assess the effects of ITF supplementation on glycemic control .
Histological improvement of non-alcoholic steatohepatitis with a prebiotic: a pilot clinical trial
Purpose In obesity and diabetes the liver is highly susceptible to abnormal uptake and storage of fat . In certain individuals hepatic steatosis predisposes to the development of non-alcoholic steatohepatitis ( NASH ) , a disease marked by hepatic inflammation and fibrosis . Although the precise pathophysiology of NASH is unknown , it is believed that the gut microbiota-liver axis influences the development of this disease . With few treatment strategies available for NASH , exploration of gut microbiota-targeted interventions is warranted . We investigated the therapeutic potential of a prebiotic supplement to improve histological parameters of NASH . Methods In a placebo-controlled , r and omized pilot trial , 14 individuals with liver-biopsy-confirmed NASH [ non-alcoholic fatty liver activity score ( NAS ) ≥ 5 ] were r and omized to receive oligofructose ( 8 g/day for 12 weeks followed by 16 g/day for 24 weeks ) or isocaloric placebo for 9 months . The primary outcome measure was the change in liver biopsy NAS score and the secondary outcomes included changes in body weight , body composition , glucose tolerance , inflammatory markers , and gut microbiota . Results Independent of weight loss  , oligofructose improved liver steatosis relative to placebo and improved overall NAS score ( P = 0.016 ) . Bifidobacterium was enhanced by oligofructose , whereas bacteria within Clostridium cluster XI and I were reduced with oligofructose ( P < 0.05 ) . There were no adverse side effects that deterred individuals from consuming oligofructose for treatment of this disease . Conclusions Independent of other lifestyle changes , prebiotic supplementation  reduced histologically-confirmed steatosis in patients with NASH . Larger follow-up studies are warranted . Clinical TrialThis trial was registered at Clinical trials.com as NCT03184376
Moreover , subgroup analyses suggested that the effects of glycemic control were significantly influenced by the sex of the subjects and the type and the method of intake of ITF .
Conclusions Our analyses confirmed that these four main glycemic indicators were significantly reduced by ITF supplementation , particularly in the prediabetes and T2DM population .
Evidence supports that reasonable administration of ITF supplementation may have potential clinical value as an adjuvant therapy for prediabetes and T2DM management .
Background Currently , many clinical trials have shown that inulin-type fructans ( ITF ) supplementation is associated with glycemic control ; nevertheless , the results are inconclusive .
The aim of this meta- analysis of r and omized controlled trials was to assess the effects of ITF supplementation on glycemic control .