No alteration in plasma IL-6 concentration was observed .
Pentoxifylline did not alter BP or plasma IL-6 concentration , but significantly reduced circulating TNF-α and CRP concentrations
INTRODUCTION Pentoxifylline is a xanthine derivative with potential cardiovascular benefits .
AIM To evaluate the impact of pentoxifylline on  blood pressure ( BP )  and plasma TNF-α , C-reactive protein ( CRP ) and IL-6 through a systematic review and meta- analysis of r and omized controlled trials .
OXPENTIFYLLINE IN ENDOTOXAEMIA
Oxpentifylline ( pentoxifylline ) , which is known to have pharmacological effects in animal models of respiratory distress syndrome , multiorgan failure , and shock , was tested in human beings after injection of endotoxin . Of ten healthy volunteers , nine met the inclusion criterion of a rise in body temperature of at least 1.0 degrees C after 100 ng endotoxin ( Salmonella abortus equi ) as a bolus injection .  Serum levels of tumour necrosis factor alpha ( TNF ) and interleukin-6 ( IL-6 ) were both significantly higher than baseline levels 2 h and 3 h after endotoxin injection . 3 weeks later the nine volunteers were again injected with 100 ng endotoxin and oxpentifylline ( 500 mg over 4 h ) was also infused . There was no rise in TNF levels , though IL-6 levels rose in parallel with body temperature . These data suggest that oxpentifylline blocks the endotoxin-induced synthesis of TNF in man and , therefore , could possibly have beneficial effects in clinical endotoxaemia
No alteration in plasma IL-6 concentration was observed .
Pentoxifylline did not alter BP or plasma IL-6 concentration , but significantly reduced circulating TNF-α and CRP concentrations
INTRODUCTION Pentoxifylline is a xanthine derivative with potential cardiovascular benefits .
AIM To evaluate the impact of pentoxifylline on  blood pressure ( BP )  and plasma TNF-α , C-reactive protein ( CRP ) and IL-6 through a systematic review and meta- analysis of r and omized controlled trials .