Conclusions In the context of low SFAs , high-MUFA diets in isocaloric substitution for high-CHO diets did not affect blood pressure in individuals with and without hypertension .
Context Current dietary guidelines for cardiovascular disease risk management recommend restricting intake of saturated fatty acids ( SFAs ) .
However , the optimal macronutrient profile , in the context of a low-SFA diet , remains controversial .
The blood-pressure effect of replacing SFAs in diets with monounsaturated fatty acids ( MUFAs ) compared with carbohydrate has not been quantified to date .
The effects of dietary lipid modification on blood pressure, cardiovascular reactivity and sympathetic activity in man
Objectives : To examine the effect of dietary lipid modification on 24-h ambulatory blood pressure , cardiovascular reactivity and sympathetic activity in man Design : Twenty-four normal volunteers consumed either a high-fat or a low-fat diet for 2 weeks in an open , r and omized , crossover study of duration 6 weeks . Diets were isocaloric and balanced for sodium and potassium content Methods : Cardiovascular reactivity was assessed by measurement of blood pressure responses to incremental infusions of angiotensin II and noradrenaline , and to sympathetic reflex testing . Plasma noradrenaline spillover and clearance rates were estimated using [3H]-noradrenaline infusion Results : Total plasma cholesterol and low-density lipoprotein-cholesterol levels both fell significantly on the low-fat compared with the high-fat diet , as did heart rate and mean arterial pressure ( recorded by 24-h ambulatory monitoring ) . These changes were accompanied by reductions in blood pressure responses to cold pressor testing and to noradrenaline infusion on the low-fat diet . Plasma noradrenaline spillover and clearance rates did not change . Post hoc analysis showed an association between oral contraceptive use and increased noradrenaline sensitivity on the high-fat diet among the females tested . Conclusion : Dietary fat intake alters heart rate , blood pressure and cardiovascular reactivity to noradrenaline in man without changes in basal noradrenaline metabolism
Conclusions In the context of low SFAs , high-MUFA diets in isocaloric substitution for high-CHO diets did not affect blood pressure in individuals with and without hypertension .
Context Current dietary guidelines for cardiovascular disease risk management recommend restricting intake of saturated fatty acids ( SFAs ) .
However , the optimal macronutrient profile , in the context of a low-SFA diet , remains controversial .
The blood-pressure effect of replacing SFAs in diets with monounsaturated fatty acids ( MUFAs ) compared with carbohydrate has not been quantified to date .