Although , the meta- analysis conducted included a few number of studies , but has shown promising results on the effectiveness of N. sativa on glucose homeostasis and serum lipids .
BACKGROUND & OBJECTIVE ( S ) Global prevalence of type 2 diabetes ( T2D ) is very high and is currently growing alarmingly .
With respect to recent research ers ' attention to the potential role of herbal medicine in disease prevention and management , the present meta- analysis review investigates the effectiveness of Nigella sativa ( N. sativa ) , a popular herb , in T2D .
Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats.
This experiment was carried out to investigate the effect of N. sativa L. on histopathology of pancreatic beta-cells , and blood insulin and glucose concentrations in streptozotocin-induced diabetic rats . Fifty male Wistar rats ( 200 - 250 g ) were divided into two experimental groups ( diabetics with no treatment and diabetics with N. sativa L. treatment ) , each containing twenty-five rats . Diabetes was induced in both groups by a single intraperitoneal injection of streptozotocin ( STZ ) ( 50 mg/kg ) . The experimental animals in both groups became diabetic within 24 hours after the administration of STZ . The rats in N. sativa L.-treated group were given the daily intraperitoneal injection of 0.20 ml/kg of N. sativa L. volatile oil for 30 days starting the day after STZ injection . Control rats received only the same amount of normal saline solution . The rats in both groups received the last injection 24 hours before the sacrification and 5 r and omly-selected rats in each group were sacrificed before , and the 1 , 10 , 20 and 30 days after the STZ injection to collect blood and pancreatic tissue sample s. The N. sativa L. treatment caused a decrease in the elevated serum glucose , an increase in the lowered serum insulin concentrations and partial regeneration/ proliferation of pancreatic beta-cells in STZ-induced diabetic rats with the elapse of the experiment . It is concluded that the hypoglycaemic action of N. sativa L. could be partly due to amelioration in the beta-cells of pancreatic islets causing an increase in insulin secretion . More studies are needed to demonstrate the exact mechanism of action of N. sativa L. on ameliorated blood glucose concentration in STZ-induced diabetes
Although , the meta- analysis conducted included a few number of studies , but has shown promising results on the effectiveness of N. sativa on glucose homeostasis and serum lipids .
BACKGROUND & OBJECTIVE ( S ) Global prevalence of type 2 diabetes ( T2D ) is very high and is currently growing alarmingly .
With respect to recent research ers ' attention to the potential role of herbal medicine in disease prevention and management , the present meta- analysis review investigates the effectiveness of Nigella sativa ( N. sativa ) , a popular herb , in T2D .