In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .
Connective tissue-cementum regeneration: a new histologic regeneration following the use of enamel matrix derivative in dehiscence-type defects. A dog model.
The goal of this investigation was to evaluate histologically and histometrically the healing process in dehiscence-type defects treated by enamel matrix derivative ( EMD ) .  Five adult female beagle dogs were used . Buccal osseous dehiscences were surgically created on the maxillary canines and the second and fourth premolars . Thirty defect sites were r and omly assigned to treatment and control groups ( 15 defect sites for each group ) . The treatment group received EMD application , while the control groups received no EMD . After 4 months of healing , the dogs were sacrificed and tissue blocks were prepared . Histometric parameters were employed to evaluate the type of periodontal tissues that formed in the defects . All created dehiscence defects in the test sites treated by EMD had formed functional connective tissue fibers inserted into regenerated cellular cementum . The mean amount of apicocoronal regenerated cementum was 3.74 + /- 0.43 mm in EMD- treated sites , whereas the control sites had not formed cementum in the created dehiscence defects ( P < .000 ) . Statistically significant differences were found between treatment and control sites . Within the limits of this study , it can be concluded that EMD alone effectively promoted new cementum and functionally oriented connective tissue formation
In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .