There is very limited and low- quality evidence to support for a causal link between knee joint loading during walking and structural progression of knee OA .
OBJECTIVE We performed a systematic review , meta- analysis and assessed the evidence supporting a causal link between knee joint loading during walking and structural knee osteoarthritis ( OA ) progression .
Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study.
OBJECTIVE To determine in a prospect i ve population -based cohort study relationships between different measures of body mass and the incidence of severe knee and hip osteoarthritis defined as arthroplasty of knee or hip due to osteoarthritis . MATERIAL S AND METHODS  Body mass index ( BMI ) , waist circumference , waist-hip ratio ( WHR ) , weight and percentage of body fat ( BF% )  were measured at baseline in 11,026 men and 16,934 women from the general population . The incidence of osteoarthritis over 11 years was monitored by linkage with the Swedish hospital discharge register . RESULTS 471 individuals had knee osteoarthritis and 551 had hip osteoarthritis . After adjustment for age , sex , smoking and physical activity , the relative risks ( RR ) of knee osteoarthritis ( fourth vs first quartile ) were 8.1 ( 95 % CI 5.3 to 12.4 ) for BMI , 6.7 ( 4.5 to 9.9 ) for waist circumference , 6.5 ( 4.6 to 9.43 ) for weight , 3.6 ( 2.6 to 5.0 ) for BF% and 2.2 ( 1.7 to 3.0 ) for WHR . Corresponding RR for hip osteoarthritis were 2.6 ( 2.0 to 3.4 ) for BMI , 3.0 ( 2.3 to 4.0 ) for weight , 2.5 ( 1.9 to 3.3 ) for waist , 1.3 ( 0.99 to 1.6 ) for WHR and 1.5 ( 1.2 to 2.0 ) for BF% . CONCLUSION All measures of overweight were associated with the incidence of knee osteoarthritis , with the strongest relative risk gradient observed for BMI . The incidence of hip osteoarthritis showed smaller but significant differences between normal weight and obesity . Our results support a major link between overweight and biomechanics in increasing the risk of knee and hip osteoarthritis in men and women
There is very limited and low- quality evidence to support for a causal link between knee joint loading during walking and structural progression of knee OA .
OBJECTIVE We performed a systematic review , meta- analysis and assessed the evidence supporting a causal link between knee joint loading during walking and structural knee osteoarthritis ( OA ) progression .