The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation .
Conclusion : This meta- analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels
ABSTRACT Objective : The aim of this systematic review and meta- analysis was to determine and clarify the impact of curcuminoids on  serum lipid levels .
Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial.
Curcuminoids are bioactive polyphenolics with potent antiinflammatory properties . Although several lines of in vitro and pre clinical evidence suggest potent anticancer effects of curcuminoids , clinical findings have not been conclusive . The present r and omized double-blind placebo-controlled trial aim ed to evaluate the efficacy of curcuminoids as adjuvant therapy in cancer patients . Eighty subjects with solid tumors who were under st and ard chemotherapy regimens were r and omly assigned to a bioavailability-boosted curcuminoids preparation ( 180 mg/day ; n = 40 ) or matched placebo ( n = 40 ) for a period of 8 weeks . Efficacy measures were changes in the health-related quality of life ( QoL ) score ( evaluated using the University of Washington index ) and serum levels of a panel of mediators implicated in systemic inflammation including interleukins 6 ( IL-6 ) and 8 ( IL-8 ) , TNF-α , transforming growth factor-β ( TGFβ ) , high-sensitivity C-reactive protein ( hs-CRP ) , calcitonin gene-related peptide ( CGRP ) , substance P and monocyte chemotactic protein-1 ( MCP-1 ) . Curcuminoid supplementation was associated with a significantly greater improvement in QoL compared with placebo ( p < 0.001 ) . Consistently , the magnitude of reductions in TNF-α ( p < 0.001 ) , TGFβ ( p < 0.001 ) , IL-6 ( p = 0.061 ) , substance P ( p = 0.005 ) , hs-CRP ( p < 0.001 ) , CGRP ( p < 0.001 ) and MCP-1 ( p < 0.001 ) were all significantly greater in the curcuminoids versus placebo group . In contrast , the extent of reduction in serum IL-8 was significantly greater with placebo versus curcuminoids ( p = 0.012 ) . Quality of life variations were associated with changes in serum TGFβ levels in both correlation and regression analyses . Adjuvant therapy with a bioavailable curcuminoid preparation can significantly improve QoL and suppress systemic inflammation in patients with solid tumors who are under treatment with st and ard chemotherapy protocol
The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation .
Conclusion : This meta- analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels
ABSTRACT Objective : The aim of this systematic review and meta- analysis was to determine and clarify the impact of curcuminoids on  serum lipid levels .