The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .
Inflammatory markers following laparoscopic and open hernia repair
Laparoscopic surgery may reduce the inflammatory response to surgery by the avoidance of a skin incision which is frequently the site of maximum tissue trauma . We hypothesized that the inflammatory response is less with minimally invasive procedures . The aim of this study was to evaluate the response of inflammatory mediators following laparoscopic and open hernia repair . Thirty-four patients undergoing unilateral primary inguinal hernia repair were prospect ively assigned to either laparoscopic mesh hernia repair ( n=14 ) , open mesh hernia repair ( n=11 ) , or a Bassini repair ( n=9 ) . Serum sample s withdrawn prior to surgery , 6 h after surgery , and then again at 24 h after surgery were assayed for interleukin-6 and C-reactive protein content . Interleukin-6 levels at 24 h in the laparoscopic ( 13.1±3.1 pg/ml ) , open mesh ( 15.5±2.5 pg/ml ) , or Bassini group ( 15.4±2.0 pg/ml ) did not differ significantly . Neither did C-reactive protein levels at 24 h in the laparoscopic ( 12.4±2.7 pg/ml ) , open mesh ( 23.0±7.8 pg/ml ) , or Bassini group ( 18.6±6.6 pg/ml ) differ significantly . The response of inflammatory mediators to hernia repair is not modified by undertaking the procedure laparoscopically
The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .