RESULTS The meta- analysis of observational studies showed a weaker slope of dose-response relations than the meta- analysis of RCTs .
The obtained dose-response estimate between vitamin B-12 intake and status provides complementary evidence to underpin recommendations for a vitamin B-12 intake of population
BACKGROUND Many r and omized controlled trials ( RCTs ) and observational studies have provided information on the association between vitamin B-12 intake and biomarkers .
The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence .
OBJECTIVE We systematic ally review ed studies that investigated vitamin B-12 intake and biomarkers of vitamin B-12  status and estimated dose-response relations with the use of a meta- analysis .
Reduction of C-reactive protein levels through use of a multivitamin.
PURPOSE Elevated C-reactive protein levels are associated with the risk of cardiovascular disease and diabetes . We examined whether multivitamins reduce C-reactive protein levels . METHODS We performed a post hoc subgroup analysis of a 6-month , r and omized , double-blind , placebo-controlled trial . Patients ( n = 87 ; mean age , 53 years ) for whom frozen plasma sample s were available ; who did not have an inflammatory condition at baseline ; and who were not hospitalized , taking antibiotics , smoking , or starting statin therapy during the study were included .  C-reactive protein and plasma vitamin levels  were measured at baseline and 6 months . RESULTS At 6 months , C-reactive protein levels were significantly lower in the multivitamin group than in the placebo group ( between-group difference = -0.91 mg/L ; 95 % confidence interval : -1.52 to -0.30 ; P= 0.005 ) . The reduction in C-reactive protein levels was most evident in patients who had elevated levels ( > or = 1.0 mg/L ) at baseline . Of the six vitamins measured ( C , E , B(6 ) , B(12 ) , folate , and beta carotene ) , only vitamin B(6 ) ( baseline : r = -0.31 , P= 0.003 ; 6 months : r = -0.29 , P= 0.006 ) and vitamin C ( baseline : r = -0.25 , P= 0.02 ) were inversely associated with C-reactive protein level . CONCLUSION In a post hoc analysis of a r and omized , double-blind , placebo-controlled study , multivitamin use was associated with lower C-reactive protein levels . Other similarly formulated multivitamins may yield comparable results
RESULTS The meta- analysis of observational studies showed a weaker slope of dose-response relations than the meta- analysis of RCTs .
The obtained dose-response estimate between vitamin B-12 intake and status provides complementary evidence to underpin recommendations for a vitamin B-12 intake of population
BACKGROUND Many r and omized controlled trials ( RCTs ) and observational studies have provided information on the association between vitamin B-12 intake and biomarkers .
The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence .
OBJECTIVE We systematic ally review ed studies that investigated vitamin B-12 intake and biomarkers of vitamin B-12  status and estimated dose-response relations with the use of a meta- analysis .