This meta- analysis demonstrated that resveratrol supplementation among patients with MetS and related disorders  significantly reduced total cholesterol and increased GGT concentrations , but did not affect triglycerides , LDL- , HDL-cholesterol , ALT , and AST concentrations .
This data suggests that resveratrol may have a potential cardio-protective effect in patients with MetS and related disorders
There are current trials investigating the effect of resveratrol supplementation on lipid profiles and liver enzymes among patients with metabolic syndrome ( MetS ) and related disorders ; however , their findings are controversial .
This systematic review and meta- analysis were aim ed to determine the effects of resveratrol supplementation on lipid profiles and liver enzymes among patients with MetS and related disorders .
Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver
Abstract Background and Aims Nonalcoholic fatty liver disease is epidemiologically associated with hepatic and metabolic disorders . The aim of this study was to examine whether hepatic fat accumulation has a causal role in determining liver damage and insulin resistance . Methods We performed a Mendelian r and omization analysis using risk alleles in PNPLA3 , TM6SF2 , GCKR and MBOAT7 , and a polygenic risk score for hepatic fat , as instruments . We evaluated complementary cohorts of at‐risk individuals and individuals from the general population : 1515 from the liver biopsy cohort ( LBC ) , 3329 from the Swedish Obese Subjects Study ( SOS ) and 4570 from the population ‐based Dallas Heart Study ( DHS ) . Results Hepatic fat was epidemiologically associated with liver damage , insulin resistance , dyslipidemia and hypertension . The impact of genetic variants on liver damage was proportional to their effect on hepatic fat accumulation . Genetically determined hepatic fat was associated with aminotransferases , and with inflammation , ballooning and fibrosis in the LBC . Furthermore , in the LBC , the causal association between hepatic fat and fibrosis was independent of disease activity , suggesting that a causal effect of long‐term liver fat accumulation on liver disease is independent of inflammation . Genetically determined hepatic steatosis was associated with insulin resistance in the LBC and SOS . However , this association was dependent on liver damage severity . Genetically determined hepatic steatosis was associated with liver fibrosis/cirrhosis and with a small increase in risk of type 2 diabetes in publicly available data bases . Conclusion These data suggest that long‐term hepatic fat accumulation plays a causal role in the development of chronic liver disease
This meta- analysis demonstrated that resveratrol supplementation among patients with MetS and related disorders  significantly reduced total cholesterol and increased GGT concentrations , but did not affect triglycerides , LDL- , HDL-cholesterol , ALT , and AST concentrations .
This data suggests that resveratrol may have a potential cardio-protective effect in patients with MetS and related disorders
There are current trials investigating the effect of resveratrol supplementation on lipid profiles and liver enzymes among patients with metabolic syndrome ( MetS ) and related disorders ; however , their findings are controversial .
This systematic review and meta- analysis were aim ed to determine the effects of resveratrol supplementation on lipid profiles and liver enzymes among patients with MetS and related disorders .