Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .
Helicobacter pylori seropositivity among Swedish adults with and without abdominal symptoms. A population-based epidemiologic study.
BACKGROUND The role of Helicobacter pylori in functional dyspepsia is unclear . The aim of this population -based study was to determine whether the prevalence of H. pylori infection is higher among people with dyspepsia or irritable bowel syndrome ( IBS ) than among symptomless persons after control for age , sex , and socioeconomic status . METHODS In a postal question naire we asked a representative sample ( 20 - 79 years ; n = 1260 ) from a Swedish municipality about abdominal symptoms in the preceding 3 months . A r and omly selected sub sample , 50 with dyspepsia , 50 with IBS , and 50 symptomless , matched with regard to age , sex , and education , were tested for the presence of IgG antibodies to H. pylori , using the HM-CAP immunoassay . RESULTS Fifty-five persons ( 38 % ) were H. pylori-seropositive . The seroprevalence among dyspeptics ( 33 % ) did not exceed that in healthy people ( 48 % ) or in those reporting IBS ( 33 % ) . The prevalence increased with age and with lower social class , but the latter association disappeared when age was taken into account . Neither sex nor symptom intensity predicted Helicobacter seropositivity . CONCLUSION Our data are incompatible with an important aetiologic role for H. pylori in functional dyspepsia
Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .