Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effect of Low-Dose Vitamin D Supplementation on Serum 25(OH)D in School Children and White-Collar Workers
Objective : Our study aim ed to investigate the nutritional vitamin D status of school children aged 9–15 years and white-collar workers in Zhejiang province , and evaluate the efficacy of low-dose-oral vitamin D supplementation in both population s. Methods : We conducted a prospect i ve controlled trial during March 2014 to November 2015 , comparing the efficacy of vitamin D supplements ( 400 IU/day ) with non-intervention for 18 months in school children aged 9–15 years . Meanwhile , a before-after study was conducted among white-collar workers for 1 year . Serum 25(OH)D concentration was measured at baseline and after vitamin D supplementation , respectively . Results : At the baseline , 95 % of school children and 84 % of adult participants had vitamin D deficiency ( < 20 ng/mL ) . In school children , no difference was observed between the intervention and control groups with regard to anthropometric data . Serum 25(OH)D concentrations of the school children intervention group , school children control group and white-collar workers were 12.77 ± 3.01 ng/mL , 14.17 ± 3.59 ng/mL and 16.58 ± 3.66 ng/mL at baseline and increased to 17.34 ± 3.78 ng/mL , 18.04 ± 4.01 ng/mL and 17.75 ± 5.36 ng/mL after vitamin D supplementation , respectively . Although , after adjusting for potential confounders , the 400 IU oral vitamin D supplementation increased serum 25(OH)D concentration in school children ( β = 0.81 , p = 0.0426 ) as well as in white-collar workers ( p = 0.0839 ) , the prevalence of vitamin D deficiency was still very high among school children ( 79.23 % in intervention group and 72.38 % in control group ) and white-collar workers ( 76.00 % ) . Conclusions : High prevalence of vitamin D deficiency was common in these two study population s. Daily doses of 400 IU oral vitamin D supplementation was not able to adequately increase serum 25(OH)D concentrations . A suitable recommendation regarding the level of vitamin D supplementation is required for this Chinese population
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .