Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .
Antioxidant effect of zinc in humans.
Oxidative stress is known to be an important contributing factor in many chronic diseases . We tested the hypothesis that in healthy normal volunteers zinc acts as an effective anti-inflammatory and antioxidant agent .  Ten normal volunteers were administered daily  oral zinc supplementation ( 45 mg zinc as gluconate ) and 10 volunteers received placebo for 8 weeks . Plasma zinc , MDA , HAE , and 8-OHdG levels ; LPS-induced TNF-alpha and IL-1beta mRNA ; and ex vivo TNF-alpha-induced NF-kappaB activity in mononuclear cells ( MNC ) were determined before and after supplementation . In subjects receiving zinc , plasma levels of lipid peroxidation products and DNA adducts were decreased , whereas no change was observed in the placebo group . LPS-stimulated MNC isolated from zinc-supplemented subjects showed reduced mRNA for TNF-alpha and IL-1beta compared to placebo . Ex vivo , zinc protected MNC from TNF-alpha-induced NF-kappaB activation . In parallel studies using HL-60 , a promyelocytic cell line , we observed that zinc enhances the upregulation of mRNA and DNA-specific binding for A20 , a transactivating factor which inhibits the activation of NF-kappaB. Our results suggest that zinc supplementation may lead to downregulation of the inflammatory cytokines through upregulation of the negative feedback loop A20 to inhibit induced NF-kappaB activation . Zinc administration to human subjects with conditions associated with increased oxidative stress should be explored
Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .