In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
Effect of aqueous solutions of sucralose on plaque pH.
PURPOSE To compare the effect on in vivo plaque pH of rinsing with an aqueous solution of sucralose ( alone or in combination with maltodextrin or maltodextrin and dextrose ) to the effect of rinsing with an aqueous solution of sucrose . MATERIAL S AND METHODS Each solution ( four in total ) had a sweetness equivalent to two teaspoons of sucrose in 6 oz . of water . The four test solutions were administered r and omly over four test visits ( one solution per visit ) to 10 subjects presenting 2-day resting plaque . Before , and at specified time intervals over 60 minutes following the rinse , in vivo plaque pH was monitored at six design ated sites using a Beckman 3500 digital pH meter . Data were analyzed by ANOVA . RESULTS The mean pH minimum for the sucralose rinse ( 6.56 ) was significantly higher than the sucralose/maltodextrin ( SM ) , sucralose/maltodextrin/dextrose ( SMD ) , and sucrose rinses ( 6.15 , 5.84 , and 5.29 , respectively ) . The mean delta pH ( difference between resting and minimum pH ) for the sucralose rinse ( 0.45 ) was significantly lower when compared to the SM ( 0.79 ) , SMD ( 1.14 ) , and sucrose ( 1.69 ) rinses . The differences seen in mean pH minimum and mean delta pH for the SM and SMD groups vs. the sucrose group were also statistically significant . Mean areas under the pH vs. time curve for the sucralose , SM and SMD rinses were all significantly less compared to the sucrose rinse . Rinsing with aqueous solutions of sucralose , or of sucralose in combination with maltodextrin and /or dextrose ( commercially available formulations , of sucralose ) was less acidogenic than rinsing with a sucrose solution of equivalent sweetness
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .