Overall , both forms of preventive light therapy reduced the incidence of SAD numerically compared with no light therapy .
BACKGROUND Seasonal affective disorder ( SAD ) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring .
The prevalence of SAD ranges from 1.5 % to 9 % , depending on latitude .
The predictable seasonal aspect of SAD provides a promising opportunity for prevention .
This review - one of four review s on efficacy and safety of interventions to prevent SAD - focuses on light therapy as a preventive intervention .
Light therapy is a non-pharmacological treatment that exposes people to artificial light .
Mode of delivery ( e.g. visors , light boxes ) and form of light ( e.g. bright white light ) vary .
OBJECTIVES To assess the efficacy and safety of light therapy ( in comparison with no treatment , other types of light therapy , second-generation antidepressants , melatonin , agomelatine , psychological therapies , lifestyle interventions and negative ion generators ) in preventing SAD and improving patient-centred outcomes  among adults with a history of SAD .
Feasibility study to inform the design of a randomised controlled trial to eradicate Pseudomonas aeruginosa infection in individuals with Cystic Fibrosis
Background There are controversies about the most effective treatment to eradicate first growth of Pseudomonas aeruginosa ( P aeruginosa ) from the lower airways of patients with cystic fibrosis ( CF ) . UK guidelines recommend oral treatment , but some advocate intravenous ( IV ) treatment . The objective of this study was to assess the feasibility of conducting a r and omised controlled trial comparing two treatment strategies to eradicate P aeruginosa in CF patients . Methods /Principal Findings Two surveys were conducted . Survey [ 1 ] included clinicians who were responsible for the treatment of individuals with CF , to assess their clinical practice , opinions  and  numbers of potentially eligible patients . Survey [ 2 ] included adults and young people aged 13 years or more with CF and parents of children with CF aged less than 13 years , identified at six UK CF centres , who fulfilled eligibility criteria for the proposed clinical trial , to assess their views about the interventions and their willingness to participate in the trial . Generally clinicians treat first or new growth of P aeruginosa with oral antibiotics , but 90 % reported that they would consider IV treatment of first isolation of P aeruginosa . 74 % of clinicians would consider recruiting their patients and 45 % of consumers would consider entry for themselves or their children into a trial comparing oral with intravenous antibiotics . The median rate per annum for first or new growths of P aeruginosa in adults was 3 % ( range 1 % to 9 % ) and in children was 10 % ( range 3 % to 23 % ) . If the trial was conducted across the UK , with a consent rate of 45 % , then the number of eligible patients per annum who would be willing to take part in a study would be approximately 41 adults and 203 children . Conclusions This work demonstrates the importance of feasibility studies in preparation for multicentre clinical trials . It confirmed the uncertainty amongst clinicians and patients about the clinical question , enabled assessment of the number of potentially eligible patients , the proportion of patients and clinicians prepared to participate and aspects of trial design which might encourage this . It showed that a clinical trial was feasible , but only if patients were recruited from across United Kingdom
Overall , both forms of preventive light therapy reduced the incidence of SAD numerically compared with no light therapy .
BACKGROUND Seasonal affective disorder ( SAD ) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring .
The prevalence of SAD ranges from 1.5 % to 9 % , depending on latitude .
The predictable seasonal aspect of SAD provides a promising opportunity for prevention .
This review - one of four review s on efficacy and safety of interventions to prevent SAD - focuses on light therapy as a preventive intervention .
Light therapy is a non-pharmacological treatment that exposes people to artificial light .
Mode of delivery ( e.g. visors , light boxes ) and form of light ( e.g. bright white light ) vary .
OBJECTIVES To assess the efficacy and safety of light therapy ( in comparison with no treatment , other types of light therapy , second-generation antidepressants , melatonin , agomelatine , psychological therapies , lifestyle interventions and negative ion generators ) in preventing SAD and improving patient-centred outcomes  among adults with a history of SAD .