Results Although highlighting a general lack of high- quality real-life effectiveness observational research on these clinical ly important topics , the analysis provided insights into how identified observational studies might inform asthma guidelines developers and clinicians .
Overall , RELEVANT appeared reliable and easy to use by expert review ers .
Conclusions Using such quality appraisal tools is m and atory to assess whether specific observational real-life effectiveness studies can be used to inform guideline development and /or decision-making in clinical practice
Abstract Introduction A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology ( EAACI ) and the Respiratory Effectiveness Group ( REG ) to develop a  quality assessment tool for real-life observational research to identify high- quality real-life asthma studies that could be considered within future guideline development .
Inhaler technique and asthma: feasability and acceptability of training by pharmacists.
Poor inhaler technique is frequent in asthma , but its long-term consequences have been seldom assessed . Pharmacists are ideally positioned to teach inhaler technique . This prospect i ve observational study evaluated the feasibility of inhaler training by pharmacists in patients receiving inhaled corticosteroids by pressurised metered-dose inhaler ( pMDI ) or breath-actuated MDI . In parallel , the relationships between inhaler technique , adherence , and asthma control , and their modulation one month after training were assessed . Of 727 patients receiving training at pharmacies ( n=123 ) , 61 % were prescribed a pMDI ; 35 % , an Autohaler ( ® ) ; and 5 % , an Easi-Breathe ( ® ) inhaler .  Poor asthma control ( Asthma Control Question naire score ≥ 1.5 ) at baseline was significantly ( p<0.05 ) and independently associated with poor inhaler technique and poor self-reported adherence ( Morisky score ≥ 3 ) . The percentage of patients with optimal inhaler technique rose from 24 % before to 79 % after training ( p<0.001 ) . Median training session length was 6 min . At 1 month , mean ( SD ) ACQ score had improved from a baseline score of 1.8 ( 1.2 ) to 1.4 ( 1.1 ) , ( p<0.001 ) . Importantly , greater change was observed in patients with improved inhaler technique versus those without . Similar results were observed for Morisky score . Inhaler technique is associated with adherence and influences asthma control  . Inhaler training by pharmacists is feasible and seams to improve inhaler technique , asthma control and adherence
Results Although highlighting a general lack of high- quality real-life effectiveness observational research on these clinical ly important topics , the analysis provided insights into how identified observational studies might inform asthma guidelines developers and clinicians .
Overall , RELEVANT appeared reliable and easy to use by expert review ers .
Conclusions Using such quality appraisal tools is m and atory to assess whether specific observational real-life effectiveness studies can be used to inform guideline development and /or decision-making in clinical practice
Abstract Introduction A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology ( EAACI ) and the Respiratory Effectiveness Group ( REG ) to develop a  quality assessment tool for real-life observational research to identify high- quality real-life asthma studies that could be considered within future guideline development .