Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults , results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters .
This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect
This systematic review aims to evaluate r and omised controlled trials ( RCTs ) investigating the effect of vitamin D supplementation on  endothelial function and inflammation in adults .
Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women.
Unfavorable metabolic profiles and oxidative stress in pregnancy are associated with several complications . This study was conducted to determine the effects of vitamin D supplementation on serum concentrations of high-sensitivity C-reactive protein ( hs-CRP ) , metabolic profiles , and biomarkers of oxidative stress in healthy pregnant women . This r and omized , double-blind , placebo-controlled clinical trial was conducted in 48 pregnant women aged 18 - 40 y old at 25 wk of gestation . Participants were r and omly assigned to receive either 400 IU/d cholecalciferol supplements ( n = 24 ) or placebo ( n = 24 ) for 9 wk . Fasting blood sample s were taken at study baseline and after 9 wk of intervention to quantify serum concentrations of hs-CRP , lipid concentrations , insulin , and biomarkers of oxidative stress . After 9 wk of intervention , the increases in serum 25-hydroxyvitamin D and calcium concentrations were greater in the vitamin D group ( + 3.7 μg/L and + 0.20 mg/dL , respectively ) than in the placebo group ( -1.2 μg/L and -0.12 mg/dL , respectively ; P < 0.001 for both ) . Vitamin D supplementation result ed in a significant decrease in serum hs-CRP ( vitamin D vs. placebo groups : -1.41 vs. + 1.50 μg/mL ; P-interaction = 0.01 ) and insulin concentrations ( vitamin D vs. placebo groups : -1.0 vs. + 2.6 μIU/mL ; P-interaction = 0.04 ) and a significant increase in the Quantitative Insulin Sensitivity Check Index score ( vitamin D vs. placebo groups : + 0.02 vs. -0.02 ; P-interaction = 0.006 ) , plasma total antioxidant capacity ( vitamin D vs. placebo groups : + 152 vs. -20 mmol/L ; P-interaction = 0.002 ) , and total glutathione concentrations ( vitamin D vs. placebo groups : + 205 vs. -32 μmol/L ; P-interaction = 0.02 ) compared with placebo . Intake of vitamin D supplements led to a significant decrease in fasting plasma glucose ( vitamin D vs. placebo groups : -0.65 vs. -0.12 mmol/L ; P-interaction = 0.01 ) , systolic blood pressure ( vitamin D vs. placebo groups : -0.2 vs. + 5.5 mm Hg ; P-interaction = 0.01 ) , and diastolic blood pressure ( vitamin D vs. placebo groups : -0.4 vs. + 3.1 mm Hg ; P-interaction = 0.01 ) compared with placebo . In conclusion , vitamin D supplementation for 9 wk among pregnant women has beneficial effects on metabolic status
Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults , results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters .
This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect
This systematic review aims to evaluate r and omised controlled trials ( RCTs ) investigating the effect of vitamin D supplementation on  endothelial function and inflammation in adults .