They support SIF 's  efficacy in the management of cow 's milk allergy and infant 's digestive tolerance , as well as its low cross allergy compared to cow 's milk and other formulas .
There is also evidence that demonstrates that SIFs have important advantages in terms of cost-benefit , palatability and effects on the intestinal microbiota , compared to other formulas .
Conclusions Although evidence to recommend its use in functional digestive disorders is limited , SIFs have an adequate safety profile and are still a valid option for infant feeding
Background Soy infant formulas ( SIF ) have long been used as an alternative for infants with special nutritional requirements .
However , the medical indications for their use , their allergenicity , safety and efficacy are still controversial .
Objective To present recommendations for the use of SIF based on the existing literature .
Consumption of soy-based infant formula is not associated with early onset of puberty
Purpose The use of soy products is common in young children with cow milk allergy ( CMA ) . The aim was to examine prospect ively the association between infantile consumption of soy-based formula , growth parameters and early pubertal signs , in comparison to cow milk-based formula . Methods A nested case – control study was conducted , selected from a cohort of infants prospect ively followed from birth until the age of 3 years for eating habits and the development of IgE-mediated CMA . Infants who consumed only soy-based formula  were included in the soy group . The control group was r and omly selected from those without IgE-CMA and not receiving soy formula . Study participants were reevaluated between ages 7.8 and 10.5 years by an interview , nutritional intake by 3 days diaries , and height , weight , and pubertal signs by physical examination . Results The  soy-fed group included 29 participants ( 17 males ) , median age 8.92 years IQR ( 8.21 , 9.42 ) . The control group included 60 participants ( 27 males ) , median age 8.99 years IQR ( 8.35 , 9.42 ) . The groups had comparable height and BMI z scores ( − 0.17 ± 1.08 versus − 0.16 ± 1.01 , p = 0.96 , and 0.67 ± 1.01 versus 0.53 ± 1.02 , p = 0.56 , for soy and control groups , respectively ) . Four ( three males and one female ) from the soy-group ( 13.8 % ) and eight females from the control-group ( 13.3 % ) had early pubertal signs ( p = 0.95 ) . No association was detected between puberty and infantile nutrition , after controlling for BMI and family data . No association with puberty or differences between groups were found in current daily consumption  of soy , micronutrients , energy , carbohydrates , fat , and protein . Conclusions This is the first prospect i ve , physical examination-based study , demonstrating no association between infantile soy-based formula consumption and growth and puberty parameters
They support SIF 's  efficacy in the management of cow 's milk allergy and infant 's digestive tolerance , as well as its low cross allergy compared to cow 's milk and other formulas .
There is also evidence that demonstrates that SIFs have important advantages in terms of cost-benefit , palatability and effects on the intestinal microbiota , compared to other formulas .
Conclusions Although evidence to recommend its use in functional digestive disorders is limited , SIFs have an adequate safety profile and are still a valid option for infant feeding
Background Soy infant formulas ( SIF ) have long been used as an alternative for infants with special nutritional requirements .
However , the medical indications for their use , their allergenicity , safety and efficacy are still controversial .
Objective To present recommendations for the use of SIF based on the existing literature .