In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .
Postingestive inhibition of food intake by aspartame: Importance of interval between aspartame administration and subsequent eating
Aspartame administered in capsules ( i.e. , without tasting ) 1 h before a meal significantly reduces the amount eaten in that meal . In the present study 36 young men and women were divided into 3 groups of 12 to receive aspartame ( 400 mg ) or placebo ( 400 mg starch ) on separate occasions either 5 min ( Group A ) , 30 min ( Group B ) or 60 min ( Group C ) before beginning an ad lib test meal . Compared with placebo , aspartame reduced food intake in Group C ( by 18.5 % , p < 0.01 ) , but did not reliably affect intake in Groups A or B. There were , in contrast , no significant effects of aspartame on premeal ratings of hunger , desire to eat or fullness for any of the groups . These results confirm a postingestive inhibitory action of aspartame on appetite , which may involve the amplification of the satiating effects of food . The lack of effect of aspartame administered at the shorter intervals before eating suggests a postgastric or even postabsorptive mechanism of action . This observation is also important in its implication s for the possible therapeutic exploitation of the anorexic effect of capsulated aspartame
In healthy subjects , appetite and short term food intake , risk of cancer , risk of diabetes , risk of dental caries , weight gain and risk of obesity are the most investigated health outcomes .
Overall there is no conclusive evidence for beneficial and harmful effects on those outcomes .
In subjects with diabetes and hypertension , the evidence regarding health outcomes of NNS use is also inconsistent .
Background Food products containing non-nutritive sweeteners ( NNSs ) instead of sugar have become increasingly popular in the last decades .
Their appeal is obviously related to their calorie-free sweet taste .
However , with the dramatic increase in their consumption , it is reasonable and timely to evaluate their potential health benefits and , more importantly , potential adverse effects .
The main aim of this scoping review was to map the evidence about health outcomes possibly associated with regular NNS consumption by examining the extent , range , and nature of research activity in this area .