We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
Period-specific growth, overweight and modification by breastfeeding in the GINI and LISA birth cohorts up to age 6 years
Children ’s weight/growth development is age-specific and may be influenced by breastfeeding . We therefore assessed velocities of weight , length , body-mass-index and overweight/obesity development from birth up to age 6 years overall and in relation to breastfeeding . The method of this study is based on pooled data of the birth-cohorts GINI-plus and LISA-plus and follows 7,643 healthy full-term neonates in four study -centers in Germany . Up to nine anthropometric measurements are available . Overweight/obesity is percentile-defined according to WHO-Child-Growth-St and ards .  Fully-breastfed  is defined as  breastfed for at least 4 months . Piecewise-linear-r and om-coefficient-models were applied to assess growth trajectories and velocities between 0–3 , 3–6 , 6–12 , 12–24 and beyond 24th months . Velocities for weight- , length- and BMI -development are highest in the first 3 months after birth and diminish , with differing pace , in the periods that follow . For overweight and obesity , peak-velocities are estimated in periods 6–12 and 3–6 months . The difference in the velocity of weight gain for breastfed vs. other children is −18 g/month in the first 3 month , −93 g/month between month 3 and 6 , −14 g/month between month 6 and 12 and −3 g/month beyond the 24th month . Velocities in length are not different between breastfed and non-breastfed children . Over time , a slightly lower risk ( difference < 2 % ) of being overweight was estimated for breastfed children , after adjustment for study -center , socio-economic-status and maternal smoking in pregnancy . Infants fully-breastfed gain less weight , but grow equally in length in the first 12 months of life versus mixed or formula-fed children . The protective effect of breastfeeding on becoming overweight is related to its weight-velocity-modifying-effect in early infancy
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .