Probiotic interventions were effective for treatment and prevention of BV , prevention of recurrences of c and idiasis and UTIs , and clearing HPV lesions .
Although clinical practice recommendations were limited by the strength of evidence , probiotic interventions were effective in treatment and prevention of urogenital infections as alternatives or co-treatments .
INTRODUCTION Probiotics are a complementary and integrative therapy useful in the treatment and prevention of urogenital infections in women .
This study extends the work of research ers who systematic ally investigated the scientific literature on probiotics to prevent or treat urogenital infections .
Phase 2a Study Assessing Colonization Efficiency, Safety, and Acceptability of Lactobacillus crispatus CTV-05 in Women With Bacterial Vaginosis
Background : Bacterial vaginosis ( BV ) is a common vaginal infection caused by a lack of endogenous lactobacilli and overgrowth of pathogens that frequently recurs following antibiotic treatment . Methods : A phase 2a study assessed colonization efficiency , safety , tolerability , and acceptability of Lactobacillus crispatus CTV-05 ( LACTIN-V ) administered by a vaginal applicator . Twenty-four women with BV were r and omized in a 3:1 ratio of active product to placebo . Participants used LACTIN-V at 2 × 109 colony-forming units (cfu)/dose or placebo for 5 initial consecutive days , followed by a weekly application over 2 weeks . They returned for follow-up on Days 10 and 28 . Results : Sixty-one percent of the 18 women r and omized to the LACTIN-V group were colonized with L. crispatus CTV-05 at Day 10 or Day 28 . Among LACTIN-V users with complete adherence to the study regimen , 78 % were colonized at Day 10 or Day 28 . Of the 120 adverse events ( AEs ) that occurred , 108 ( 90 % ) and 12 ( 10 % ) were of mild and moderate severity , respectively . AEs were evenly distributed between the LACTIN-V and placebo group . Of the total AEs , 93 ( 78 % ) were genitourinary in origin . The most common genitourinary AEs included vaginal discharge ( 46 % ) , abdominal pain ( 46 % ) , dysuria ( 21 % ) , pollakiuria ( 21 % ) , vaginal odor ( 21 % ) , and genital pruritus ( 17 % ) . No grade 3 or 4 AEs or serious AEs occurred and no deep epithelial disruption was seen during colposcopic evaluation . The product was well tolerated and accepted . Conclusions : LACTIN-V colonized well , and was safe and acceptable in women treated for BV
Probiotic interventions were effective for treatment and prevention of BV , prevention of recurrences of c and idiasis and UTIs , and clearing HPV lesions .
Although clinical practice recommendations were limited by the strength of evidence , probiotic interventions were effective in treatment and prevention of urogenital infections as alternatives or co-treatments .
INTRODUCTION Probiotics are a complementary and integrative therapy useful in the treatment and prevention of urogenital infections in women .
This study extends the work of research ers who systematic ally investigated the scientific literature on probiotics to prevent or treat urogenital infections .