Despite limitations in these data , our NMA findings are in line with existing evidence on the metabolic effects of fat and support current recommendations to replace high saturated-fat food with unsaturated oils
The aim of this network meta- analysis ( NMA ) is to compare the effects of different oils/solid fats on blood lipids .
Effect of diets high in butter, corn oil, or high-oleic acid sunflower oil on serum lipids and apolipoproteins in men.
This r and omized blind crossover study compared  serum lipid and apolipoprotein concentrations in 20 men consuming 37 - 43 % of energy as fat from diets based on corn oil , high-oleic acid sunflower oil , and butter .  Each phase of the crossover design included 2 wk of butter-based diet followed by 5 wk of design ated vegetable-oil-based diet with a 7-wk washout period between phases . Compared with values for the butter-based diet , the vegetable-oil-based diets reduced serum total cholesterol by 16 - 21 % ( p less than 0.001 ) , LDL cholesterol by 21 - 26 % ( p less than 0.001 ) , triglycerides by 10 - 21 % ( p less than 0.01 for the higher figure ) , and apolipoprotein B-100 by 22 - 29 % ( p less than 0.001 ) . When values fell , they fell further on the corn-oil-based diet . There were no significant changes in serum HDL cholesterol or apolipoprotein A-1 . These data suggest that when men on diets high in saturated fatty acids reduce their saturated fatty acid intake but not their total fat intake , many can still experience a significant lowering in serum total cholesterol
Despite limitations in these data , our NMA findings are in line with existing evidence on the metabolic effects of fat and support current recommendations to replace high saturated-fat food with unsaturated oils
The aim of this network meta- analysis ( NMA ) is to compare the effects of different oils/solid fats on blood lipids .