Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .
Home-delivered problem adaptation therapy (PATH) for depressed, cognitively impaired, disabled elders: A preliminary study.
OBJECTIVES This preliminary study examines the efficacy of 12-week home-delivered problem adaptation therapy ( PATH ) versus home-delivered supportive therapy ( ST ) in reducing  depression and disability in 30 depressed , cognitively impaired , disabled older adults . DESIGN A 12-week r and omized clinical trial . Research assistants were unaware of the participants ' r and omization status . Assessment s were conducted at baseline , 6 weeks , and 12 weeks . SETTING Weill-Cornell Advanced Center for Interventions and Services Research . PARTICIPANTS Thirty elders with major depression , cognitive impairment , and disability were recruited through advertisement and the Home-Delivered Meals Program of the Westchester County Department of Senior Programs and Services . INTERVENTION PATH is a home-delivered intervention design ed to reduce depression and disability in depressed , cognitively impaired , disabled elders .  PATH is based on problem-solving therapy and integrates environmental adaptation and caregiver participation . PATH is consistent with Lawton 's ecologic model of adaptive functioning in aging . MEASUREMENTS Depression and disability were measured with Hamilton Depression Rating Scale-24 items and Sheehan Disability Scale , respectively . Client Satisfaction Question naire was used to assess patient satisfaction with treatment . RESULTS Mixed-effects model analyses revealed that PATH was more efficacious than ST in reducing depression and disability at 12 weeks . Participants in both treatment groups were satisfied with treatment . CONCLUSIONS This preliminary study suggests that PATH is well accepted and efficacious in depressed elders with major depression , cognitive impairment , and disability . Because this population may not adequately respond to antidepressant medication treatment , PATH may provide relief to many patients who would otherwise remain depressed and continue to suffer
Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .