Compared with an energy-restricted SP diet , an isocalorically prescribed HP diet provides modest benefits for reductions in body weight , FM , and triglycerides and for mitigating reductions in FFM and REE
BACKGROUND It is currently unclear whether altering the carbohydrate-to-protein ratio of low-fat , energy-restricted diets augments weight loss and cardiometabolic risk markers .
OBJECTIVE The objective was to conduct a systematic review and meta- analysis of studies that compared energy-restricted , isocaloric , high-protein , low-fat ( HP ) diets with st and ard-protein , low-fat ( SP ) diets on weight loss , body composition , resting energy expenditure ( REE ) , satiety and appetite , and cardiometabolic risk factors .
High-protein, low-fat diets are effective for weight loss and favorably alter biomarkers in healthy adults.
Although popular and effective for weight loss , low-carbohydrate , high-protein , high-fat ( Atkins ) diets have been associated with adverse changes in blood and renal biomarkers . High-protein diets low in fat may represent an equally appealing diet plan but promote a more healthful weight loss .  Healthy adults ( n = 20 ) were r and omly assigned to 1 of 2 low-fat ( < 30 % energy ) , energy-restricted groups : high-protein ( 30 % energy ) or high-carbohydrate ( 60 % energy ) ; 24-h intakes were strictly controlled during the 6-wk trial . One subject from each group did not complete the trial due to out-of-state travel ; two subjects in the high-carbohydrate group withdrew from the trial due to extreme hunger . Body composition and metabolic indices were assessed pre- and post-trial . Both diets were equally effective at reducing body weight ( -6 % , P < 0.05 ) and fat mass ( -9 to -11 % , P < 0.05 ) ; however , subjects consuming the high-protein diet reported more satisfaction and less hunger in mo 1 of the trial . Both diets significantly lowered total cholesterol ( -10 to -12 % ) , insulin ( -25 % ) , and uric acid ( -22 to -30 % ) concentrations in blood from fasting subjects . Urinary calcium excretion increased 42 % in subjects consuming the high-protein diet , mirroring the 50 % increase in dietary calcium with consumption of this diet ; thus , apparent calcium balance was not adversely affected . Creatinine clearance was not altered by diet treatments , and nitrogen balance was more positive in subjects consuming the high-protein diet vs. the high-carbohydrate diet ( 3.9 + /- 1.4 and 0.7 + /- 1.7 g N/d , respectively , P < 0.05 ) . Thus , low-fat , energy-restricted diets of varying protein content ( 15 or 30 % energy ) promoted healthful weight loss , but diet satisfaction was greater in those consuming the high-protein diet
Compared with an energy-restricted SP diet , an isocalorically prescribed HP diet provides modest benefits for reductions in body weight , FM , and triglycerides and for mitigating reductions in FFM and REE
BACKGROUND It is currently unclear whether altering the carbohydrate-to-protein ratio of low-fat , energy-restricted diets augments weight loss and cardiometabolic risk markers .
OBJECTIVE The objective was to conduct a systematic review and meta- analysis of studies that compared energy-restricted , isocaloric , high-protein , low-fat ( HP ) diets with st and ard-protein , low-fat ( SP ) diets on weight loss , body composition , resting energy expenditure ( REE ) , satiety and appetite , and cardiometabolic risk factors .