D and PA+D  interventions had larger effects on glucose reduction  than PA alone .
Lifestyle  interventions significantly improved FPG , HbA1c , FI , HOMA-IR , and bodyweight among adults without IGT or diabetes , and might reduce progression of hyperglycemia to type 2 diabetes mellitus
This study systematic ally assessed the effectiveness of lifestyle interventions on glycemic indicators among adults ( ⩾18years ) without IGT or diabetes .
Evaluation of a primary care-oriented brief counselling intervention for obesity with and without orlistat.
OBJECTIVE There is a significant need for an obesity treatment model suitable for the primary care environment . We examined the effectiveness of a brief counselling intervention alone , in combination with orlistat , and drug-alone in a 12-month r and omized- clinical trial at a medical school obesity centre . METHODS Participants ( N = 250 ) with body mass index ( BMI ) > or=27 were r and omized .  Changes in body weight , lipids , blood pressure and serum glucose were examined . Drug adherence and attendance were also evaluated . RESULTS Completers analysis was conducted on 136 participants with data at baseline , 6 and 12 months and intention-to-treat analyses ( ITT ) for the total sample . Amongst completers , participants in the drug only ( P = 0.012 ) and drug + brief counselling ( P = 0.001 ) groups lost more weight ( mean + /- SD : -3.8 + /- 5.8 kg and -4.8 + /- 4.4 kg , respectively ) than participants in the brief counselling only group at 6 months ( -1.7 + /- 3.3 kg ) , but there were no significant group differences at 12 months . ITT model results were similar to completers at 6 months and remained significant at 12 months , but the weight losses were more modest ( <3 kg ) for both groups receiving orlistat . For brief counselling alone , participants gained weight ( 1.7 + /- 4.2 kg ) . Cardiovascular disease ( CVD ) parameter changes were negligible . CONCLUSIONS Pharmacotherapy alone or combined with brief counselling result ed in modest weight losses that had minimal impact on cardiovascular parameters , but were greater than brief counselling alone . Whilst brief interventions and primary pharmacotherapy have been suggested as viable treatments for implementation in primary care setting s , our study suggests that such minimal interventions provide minimal benefits
D and PA+D  interventions had larger effects on glucose reduction  than PA alone .
Lifestyle  interventions significantly improved FPG , HbA1c , FI , HOMA-IR , and bodyweight among adults without IGT or diabetes , and might reduce progression of hyperglycemia to type 2 diabetes mellitus
This study systematic ally assessed the effectiveness of lifestyle interventions on glycemic indicators among adults ( ⩾18years ) without IGT or diabetes .