There is very limited evidence for the effectiveness of IDIs on PA and HRQoL in RA and JIA and no evidence for their effectiveness in PsA or AS
The aim of this systematic review was to evaluate the evidence from r and omised controlled trials ( RCTs ) evaluating the effectiveness of interactive digital interventions ( IDIs ) for physical activity ( PA )  and  health related quality of life ( HRQoL )  in people with Inflammatory Arthritis [ rheumatoid arthritis ( RA ) , juvenile idiopathic arthritis ( JIA ) axial Spondyloarthritis ( AS ) and psoriatic arthritis ( PsA ) ] .
The 6-min walk test (6MW) as an efficacy endpoint in pulmonary arterial hypertension clinical trials: demonstration of a ceiling effect.
BACKGROUND PAH trials traditionally use 6MW as the primary endpoint . Concerns regarding a " ceiling effect " masking efficacy have led to exclusion of patients with milder disease from most trials ( BL 6MW>450 m ) . STRIDE I evaluated the selective endothelin A receptor antagonist , sitaxsentan ( SITAX ) , in a 12-week r and omized , double-blind , trial ( 178 patients ) employing  placebo ( PBO )  , 100 mg or 300 mg SITAX orally once daily in PAH and included patients with NYHA class II , congenital heart disease and a BL 6MW>450 m , groups often excluded from previous trials . METHODS We analyzed 6MW effects For All Pts ( intention-to treat ) and those meeting Traditional enrollment criteria , defined as patients with NYHA class III or IV and 6MW < or = 450 m at BL with idiopathic PAH or PAH related to connective tissue disease . The 100 mg and 300 mg SITAX arms are pooled based on similar treatment effects on 6MW . CONCLUSION Existence of a " ceiling effect " is supported by these data . The magnitude of the treatment effect and statistical power when using 6MW as the endpoint . Comparisons between PAH trials that do not adjust for the effects of differing enrollment criteria require caution
There is very limited evidence for the effectiveness of IDIs on PA and HRQoL in RA and JIA and no evidence for their effectiveness in PsA or AS
The aim of this systematic review was to evaluate the evidence from r and omised controlled trials ( RCTs ) evaluating the effectiveness of interactive digital interventions ( IDIs ) for physical activity ( PA )  and  health related quality of life ( HRQoL )  in people with Inflammatory Arthritis [ rheumatoid arthritis ( RA ) , juvenile idiopathic arthritis ( JIA ) axial Spondyloarthritis ( AS ) and psoriatic arthritis ( PsA ) ] .