“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .
Potential protective effect of long-term therapy with Xuezhikang on left ventricular diastolic function in patients with essential hypertension.
OBJECTIVE To investigate the benefits of long-term therapy with Xuezhikang , a cholestin extract , in combination with calcium channel blockers for improvement of left ventricular ( LV ) hypertrophy and function in patients with essential hypertension , as determined using echocardiography . DESIGN Fifty-five ( 55 ) hypertensive patients with normal blood low-density lipoprotein cholesterol ( LDL-C ) levels were r and omly assigned to the Xuezhikang group ( n = 28 , 1200 mg/d of Xuezhikang ) or the placebo group ( n = 27 , matched placebo ) . All of the patients were treated with extended-release nifedipine ( 20 mg twice daily ) . Thirty ( 30 ) normotensive subjects , matched for age and gender , were selected as a control group . Conventional echocardiography and tissue Doppler imaging were used to measure the left ventricle ( LV ) wall thickness and LV diastolic function at weeks 0 , 24 , and 72 during the period of observation . The serum levels of lipids , carboxy-terminal propeptide of procollagen type I ( PIP ) , and C-reactive protein ( CRP ) were determined as well . RESULTS The hypertensive patients had significantly elevated PIP and CRP levels in serum , increased LV wall thickness , and impaired LV diastolic function compared with the normotensive subjects ( 0.01 < p < 0.05 ) . Compared with the placebo group , the transmitral flow velocities ( E/A ratio ) ( 1.11 + /- 0.36 versus 0.85 + /- 0.24 , p < 0.01 ) and the myocardial motion velocities ( Em/Am ratio ) at the septal mitral annulus ( 0.90 + /- 0.19 versus 0.70 + /- 0.18 , p < 0.05 ) and the lateral mitral annulus ( 1.06 + /- 0.20 versus 0.86 + /- 0.14 , p < 0.01 ) were significantly increased , while there was no significant change in the LV wall thickness after 72 weeks of therapy with Xuezhikang . The serum levels of PIP ( 0.43 + /- 0.13 ng/mL versus 0.51 + /- 0.20 ng/mL , p < 0.05 ) and CRP ( 0.32 + /- 0.13 mg/L versus 0.40 + /-0.17 mg/L , p < 0.05 ) were significantly reduced compared to placebo treatment . There was no significant correlation between changes in LV diastolic function and blood pressure or lipid profile with Xuezhikang therapy . CONCLUSION Long-term therapy with Xuezhikang improved LV diastolic function , probably mediated through antifibrotic and anti-inflammatory effects and independent of blood pressure and lipid profiles in patients with essential hypertension
“ RYR plus conventional therapy ” exhibited significant lowering effects on serum total cholesterol ( TC ) , low-density lipoprotein cholesterol ( LDL-C ) , and CRP but exhibited no significant effect on systolic BP , diastolic BP , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) compared with “ placebo plus conventional therapy . ” “
RYR plus conventional therapy ” showed significant lowering effects on systolic BP , TC , LDL-C , and CRP but no effect on diastolic BP , TG , and HDL-C compared with “ placebo plus conventional therapy . ”
No significant difference in BP and lipid profile between “ RYR plus conventional therapy ” and “ statins plus conventional therapy ” was observed .
“ RYR plus statins ” appeared to be more effective in lowering BP , TC , TG , and LDL-C but without a significant difference in HDL-C compared to statins .
No serious adverse events were reported .
The results of this meta- analysis suggested some supportive but limited evidence regarding RYR for hypertension .
ABSTRACT Interest is increasing regarding the potential health effects of red yeast rice ( RYR ) consumption , which is described as a “ natural statin ” in China .
This review aims to evaluate the efficacy of RYR on blood pressure ( BP ) , lipid profile , and C-reactive protein ( CRP ) in treating  hypertension .