The conversion of dialysis patients to a vitamin E-coated dialyser is associated with an improvement in circulating biomarkers of lipid peroxidation , which is of potential clinical benefit
BACKGROUND Oxidative stress is prevalent in dialysis patients and has been implicated in the pathogenesis of cardiovascular disease and anaemia .
We conducted a systematic review and meta- analysis to examine the effect of Excebrane , a vitamin E-coated cellulose-based dialyser , on circulating biomarkers of lipid peroxidation , as surrogate markers of oxidative stress .
Prospective crossover trial of the influence of vitamin E-coated dialyzer membranes on T-cell activation and cytokine induction.
Cytokine induction by dialyzer membranes has been related to several acute and chronic side effects of hemodialysis treatment , among them being immune dysfunction and progressive atherosclerosis . Surface modification of cuprophane dialyzers with the antioxidant vitamin E is a new approach to enhance biocompatibility and improve cytokine levels , as well as immune function .  Twenty-one patients undergoing treatment with hemophane ( HE ) dialyzers were enrolled onto a crossover study with a vitamin E-coated ( VE ) dialyzer or a synthetic polyamide ( PA ) dialyzer . In vitro assays of lymphocyte activation and measurements of cytokine induction were performed to evaluate biocompatibility . Four weeks of treatment with either VE or PA dialyzers enhanced in vitro proliferation of peripheral blood leukocytes in comparison to treatment with HE membranes used before study entry . Enhancement of lymphocyte function was independent of dialysis efficiency , which was kept constant during the study . In the interdialytic interval , preactivation of monocytes for the production of interleukin-6 ( IL-6 ) did not differ between VE or PA dialysis . In contrast , the VE membrane reduced acute production of IL-6 during a dialysis treatment , whereas the PA membrane did not . Unlike IL-6 , the regulatory cytokine IL-10 is not inhibited by either membrane . This is important because IL-10 is believed to have a beneficial effect on immune function in dialysis patients . The VE membrane , despite being based on a cuprophane backbone , is similar to the highly biocompatible PA dialyzer in terms of its effect on lymphocyte function , whereas it exerts an additional suppressive effect on the overproduction of proinflammatory cytokines
The conversion of dialysis patients to a vitamin E-coated dialyser is associated with an improvement in circulating biomarkers of lipid peroxidation , which is of potential clinical benefit
BACKGROUND Oxidative stress is prevalent in dialysis patients and has been implicated in the pathogenesis of cardiovascular disease and anaemia .
We conducted a systematic review and meta- analysis to examine the effect of Excebrane , a vitamin E-coated cellulose-based dialyser , on circulating biomarkers of lipid peroxidation , as surrogate markers of oxidative stress .