Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .
Calciuric effects of protein and potassium bicarbonate but not of sodium chloride or phosphate can be detected acutely in adult women and men.
An acute load test was used to test the influence of dietary factors on urinary calcium excretion . In study 1 , 10 fasting premenopausal women consumed test meals providing a moderate amount of protein ( MP ; 23 g ) , MP plus 23 mmol KHCO3 ( MP+K ) , MP plus 23 mmol NaCl ( MP+Na ) , and a high amount of protein ( HP ; 53 g ) , HP plus 70 mmol KHCO3 ( HP+K ) , and HP plus 70 mmol NaCl ( HP+Na ) . Protein was casein : lactalbumin ( 80:20 ) , except for the treatments with added sodium chloride , to which only casein was added . In study 2 , the effects of HP and HP plus 50 mmol KHCO3 ( HP+K ) were compared with those of MP or MP plus 7.5 mmol phosphate ( MP+Pi ) , equaling the additional phosphate of HP , in 10 adult men . Subjects completed all treatments in r and om order . In study 1 , the peak of calcium excretion was at 3 h for all treatments , except for HP+K , which indicated an acute hypocalciuric effect of potassium . Unexpectedly , there was no hypercalciuric effect of adding sodium chloride , nor was urine sodium increased . In study 2 , calcium excretion was significantly higher with HP than with MP+Pi but not with MP at 3 h , indicating an acute hypercalciuric effect of protein alone . A hypocalciuric effect of potassium ( HP+K compared with HP ) but not of phosphate ( MP compared with MP+Pi ) was seen . An acute load test measuring changes 3 h postload was appropriate for examining the calciuric effects of protein and potassium bicarbonate , but not those of sodium chloride or phosphate in adults
Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .