Conclusions RYGB surgery reverses the dyslipidaemia of obesity .
These findings support the use of RYGB in the management of high cardiovascular risk lipid profiles in morbid obesity
Background Obesity-related dyslipidaemia comprises hypercholesterolaemia , hypertriglyceridaemia , low HDL-cholesterol and normal to raised LDL-cholesterol levels .
40 % of morbidly obese surgical patients have dyslipidaemia .
Roux-en-Y gastric bypass ( RYGB ) surgery has many beneficial metabolic effects , but the full impact on plasma lipids has not been clearly defined .
Within- and between-subject variation in commonly measured anthropometric and biochemical variables.
BACKGROUND The biological variation of some commonly assessed metabolic variables in healthy subjects has not been studied extensively . The aim of the study was to assess , in 12 healthy subjects ( 6 male and 6 female ; mean ( SD ) age ; 22.7 ( 1.5 ) years ) following an overnight fast  , the day-to-day variation of body fat ( impedance method ) , triglycerides , nonesterified fatty acid ( NEFAs ) , glycerol , 3-hydroxybutyrate ( 3-OHB ) , lactate , glucose , insulin ( RIA ) , C-peptide , and glucagon on 12 consecutive days . METHODS Between- and within-subject coefficients of variation ( CVG and CVW ) were estimated using a r and om effects analysis of variance , and assay variation was subtracted to give the coefficient of within-subject biological variation ( CVI ) . Individuality indices were calculated as CVW/CVG . RESULTS The overall means , CVI , and individuality indices were as follows : for body fat , 24.2 % , 10 % , and 0.3 ; for triglycerides , 0.61 mmol/L , 21 % , and 1.1 ; for NEFAs , 376 micromol/L , 45 % , and 1.4 ; for glycerol , 48 micromol/L , 36 % , and 0.8 ; for 3-OHB , 43 micromol/L , 61 % , and 1.5 ; for lactate , 0.88 mmol/L , 31 % , and 1.1 ; for glucose , 4.9 mmol/L , 4.8 % , and 0.7 ; for insulin , 52 pmol/L , 26 % , and 1.0 ; for C-peptide , 0.39 nmol/L , 24 % , and 0.9 ; and for glucagon , 53 ng/L , 19 % , and 0.8 . CONCLUSIONS The data presented here are necessary for the evaluation of several important metabolic variables in individual and group studies . The biological variation of some metabolites makes it difficult to characterize the status of healthy subjects with a single measurement
Conclusions RYGB surgery reverses the dyslipidaemia of obesity .
These findings support the use of RYGB in the management of high cardiovascular risk lipid profiles in morbid obesity
Background Obesity-related dyslipidaemia comprises hypercholesterolaemia , hypertriglyceridaemia , low HDL-cholesterol and normal to raised LDL-cholesterol levels .
40 % of morbidly obese surgical patients have dyslipidaemia .
Roux-en-Y gastric bypass ( RYGB ) surgery has many beneficial metabolic effects , but the full impact on plasma lipids has not been clearly defined .