On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Buspirone Versus Methylphenidate in the Treatment of Attention Deficit Hyperactivity Disorder: A Double-Blind and Randomized Trial
The efficacy and side effects of buspirone compared with methylpheni date ( MPH ) in the treatment of children with attention-deficit/hyperactivity disorder ( ADHD ) . A total of 34 children with ADHD as defined by DSM-IV-TR were r and omized to buspirone or methylpheni date dosed on weight-adjusted basis at buspirone ( 0.5 mg/kg/day ) and methylpheni date ( 0.3–1 mg/kg/day ) for a 6-week double-blind clinical trial . The principle measures of outcome were the teacher and parent ADHD Rating Scale . The side effects were assessed by the special side effect checklist of each drug . In both groups , the scores of teacher and parent ADHD Rating Scale significantly declined on the 6th week as compared to baseline ( p = 0.001 ) . These effects were observed in the subscales too . No significant differences were observed between the two protocol s on the total scores of parent and teacher ADHD Rating Scale , but methylpheni date was superior to buspirone in decreasing the symptoms of inattention . The side effects of buspirone were mild and rare in comparison with MPH . Buspirone has a favorable side-effects profile . It also has clinical ly and statistically significant impacts on improving the ADHD symptoms in children . These preliminary findings of the efficacy of buspirone in children with ADHD need large and cross-over studies
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .