Conclusions Compared with high-dose statin therapy , ezetimibe with low-dose statin for more than 3 months may have a beneficial tendency of effects on glycemic control
Purpose Given the increased risk of incident diabetes and the side effects on glycemic control with statin treatment , statin and ezetimibe combination therapy has been widely used .
However , whether the same concern exists in ezetimibe remains uncertain .
This meta- analysis aim ed to investigate the influence of ezetimibe treatment on glycemic control .
Effect of Ezetimibe on Insulin Secretion in db/db Diabetic Mice
Objective . To investigate the effect of ezetimibe on the insulin secretion in db/db mice . Methods . The db/db diabetic mice aged 8 weeks were r and omly assigned into 2 groups and intragastrically treated with ezetimibe or placebo for 6 weeks . The age matched db/m mice served as controls . At the end of experiment , glucose tolerance test was performed and then the pancreas was collected for immunohistochemistry . In addition , in vitro perfusion of pancreatic islets was employed for the detection of insulin secretion in the first phase . Results . In the ezetimibe group , the fasting blood glucose was markedly reduced , and the total cholesterol ( TC ) and low-density lipoprotein cholesterol ( LDL-C ) were significantly lowered when compared with those in the control group ( P < 0.05 ) . At 120 min after glucose tolerance test , the area under curve in the ezetimibe group was significantly smaller than that in the control group ( P < 0.05 ) , but the AUCINS0−30 was markedly higher . In vitro perfusion of pancreatic islets revealed the first phase insulin secretion was improved . In addition , the insulin expression in the pancreas in the ezetimibe group was significantly increased as compared to the control group . Conclusion . Ezetimibe can improve glucose tolerance , recover the first phase insulin secretion , and protect the function of β cells in mice
Conclusions Compared with high-dose statin therapy , ezetimibe with low-dose statin for more than 3 months may have a beneficial tendency of effects on glycemic control
Purpose Given the increased risk of incident diabetes and the side effects on glycemic control with statin treatment , statin and ezetimibe combination therapy has been widely used .
However , whether the same concern exists in ezetimibe remains uncertain .
This meta- analysis aim ed to investigate the influence of ezetimibe treatment on glycemic control .