They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .
High-dose vitamin d intervention in infants--effects on vitamin d status, calcium homeostasis, and bone strength.
CONTEXT Guidelines in Finl and recommend 10 μg of vitamin D3 daily for all infants . Recent observations suggest that this may be insufficient to maintain optimal serum 25-hydroxyvitamin D ( S-25-OHD ) . OBJECTIVE The aim of the study was to evaluate effects of various vitamin D doses and determine a dose ensuring S-25-OHD of at least 80 nmol/liter in infants without signs of vitamin D excess . DESIGN We conducted a r and omized double-blind intervention study . Cord blood was obtained at birth for S-25-OHD ; 113 infants were r and omized to receive vitamin D3 10 , 30 , or 40 μg/d from age 2 wk to 3 months . SETTING An investigator-initiated study was performed in a single maternity hospital in Helsinki , Finl and . MAIN OUTCOME MEASURES S-25-OHD , calcium homeostasis , and skeletal characteristics were evaluated with peripheral quantitative computed tomography at age 3 months . RESULTS Baseline S-25-OHD was similar in all three groups ( median , 53 nmol/liter ) . At 3 months , the mean S-25-OHD values were 88 , 124 , and 153 nmol/liter , and the minimum values were 46 , 57 , and 86 nmol/liter in the groups receiving 10 , 30 , and 40 μg ( ANOVA ; P < 0.001 ) . No hypercalcemia occurred ; plasma calcium , serum PTH , and urine calcium excretion was similar between the groups . Peripheral quantitative computed tomography showed a trend toward larger tibial total bone and cortical bone area with higher vitamin D doses . CONCLUSION Vitamin D3 supplementation with up to 40 μg/d from age 2 wk to 3 months was safe and caused no hypercalcemia or hypercalciuria . The 40-μg dose maintained S-25-OHD above 80 nmol/liter in all infants . More extensive and longer intervention studies are necessary to assess long-term effects
They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .