RESULT ( S ) For infants , studies on psychomotor development showed no deficits , but few investigated cognitive or behavioral development .
Studies on toddlers generally reported normal cognitive , behavioral , socio-emotional , and psychomotor development .
For children in middle childhood , development seems comparable in children born after assisted reproduction and controls , although fewer studies have been conducted with follow-up to this age .
( S ) It may tentatively be concluded that the neurodevelopment of children born after  fertility treatment  is overall comparable to that in children born after spontaneous conception
OBJECTIVE To systematic ally review the existing literature on neurodevelopmental outcomes in children born after medically assisted reproduction  compared with those of children born after spontaneous conception .
Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF.
BACKGROUND To examine the long-term child outcome  after IVF until the age of 3 years in Northern Finl and , we conducted a population -based cohort study . METHODS First , a cohort of 299 IVF children born in 1990 - 1995 was compared with a cohort of 558 controls representing the general population in terms of a multiple birth rate of 1.2 % , r and omly chosen from the Finnish Medical Birth Register ( FMBR ) and matched for sex , year of birth , area of residence , parity , maternal age and social class ( full sample analyses ) . Second , IVF singletons ( n = 150 ) were compared with singleton controls ( n = 280 ) . Third , a plurality matched control cohort ( n = 100 ) for IVF twins ( n = 100 ) was r and omly chosen , matched as above , from the FMBR and analysed separately . Infant mortality rate was compared with the national rate from the FMBR . RESULTS Infant mortality in the IVF group was > 2-fold higher compared to the national rate in the general population . The risk ( OR , 95 % CI ) of low weight and height , below the lowest quartile , at 1 year of age ( 1.6 , 1.1 - 2.2 ; 1.6 , 1.1 - 2.4 ) and 2 years of age ( 1.5 , 1.1 - 2.4 ; 1.7 , 1.2 - 2.5 ) was significantly higher in the IVF group when compared with the general population control group . No statistically significant differences were found in the psychomotor development between the cohorts . Cumulative incidence of different diseases up to 3 years of age was significantly higher among IVF children in the full sample and singleton analyses ( OR , 95 % CI : 2.3 , 1.7 - 3.2 ; 2.1 , 1.3 - 3.3 respectively ) especially regarding respiratory diseases ( 3.5 , 1.9 - 6.5 ; 3.1 , 1.0 - 9.4 ) and diarrhoea ( 3.7 , 2.2 - 6.2 ; 5.7 , 2.6 - 12.7 ) , but not in twin comparisons . CONCLUSIONS The growth of IVF children was behind that of control children during the first 3 years of life , but their psychomotor development was similar . Their postnatal health was worse , probably reflecting the problems in the neonatal period
RESULT ( S ) For infants , studies on psychomotor development showed no deficits , but few investigated cognitive or behavioral development .
Studies on toddlers generally reported normal cognitive , behavioral , socio-emotional , and psychomotor development .
For children in middle childhood , development seems comparable in children born after assisted reproduction and controls , although fewer studies have been conducted with follow-up to this age .
( S ) It may tentatively be concluded that the neurodevelopment of children born after  fertility treatment  is overall comparable to that in children born after spontaneous conception
OBJECTIVE To systematic ally review the existing literature on neurodevelopmental outcomes in children born after medically assisted reproduction  compared with those of children born after spontaneous conception .