A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .
A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression.
OBJECTIVE Modafinil is approved by the U.S. Food and Drug Administration for improving wakefulness in patients with excessive sleepiness associated with narcolepsy , obstructive sleep apnea , and shift-work sleep disorder . This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression , which is often characterized by excessive sleepiness and fatigue . METHOD Eighty-five patients with bipolar depression that was inadequately responsive to a mood stabilizer with or without concomitant antidepressant therapy were r and omly assigned to receive adjunctive modafinil ( N=41 ) or placebo ( N=44 ) for 6 weeks . The primary outcome measure was baseline-to-endpoint change in score on the Inventory of Depressive Symptoms -- Clinician Rated ( IDS ) . RESULTS The baseline-to-endpoint change in IDS score was significantly greater in the modafinil group ( mean dose , 177 mg/day ) compared with the placebo group . Improvement in depressive symptoms was significantly greater in the modafinil group by week 2 , and this greater improvement was maintained at weeks 4 , 5 , and 6 . Both the response and remission rates were significantly higher in the modafinil group ( 44 % and 39 % ) compared with the placebo group ( 23 % and 18 % ) . During the 6-week study period , there was no difference between groups in treatment-emergent hypomania or mania ( six patients in the modafinil group and five in the placebo group ) or hospitalization for mania ( one in each group ) . CONCLUSIONS These data suggest that adjunctive modafinil at doses of 100 - 200 mg a day may improve depressive symptoms in patients with bipolar disorder
A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .