Meta- analysis of BMI values at end of trial showed no statistically significant difference in BMI change by use of 25[OH]D supplementation .
Based on existing published trials , oral 25[OH]D supplementation does not significantly impact BMI change
The impact of 25-hydroxyvitamin D ( 25[OH]D ) supplementation on weight change remains controversial .
The objective of this study was to summarize the effects of 25[OH]D supplementation ( cholecalciferol or ergocalciferol ) on BMI change through a meta- analysis of published clinical trials .
Overweight postmenopausal women lose bone with moderate weight reduction and 1 g/day calcium intake.
UNLABELLED Overweight postmenopausal women may be more susceptible to bone loss with weight reduction than previously studied obese women . The influence of energy restriction and Ca intake on BMD was assessed in 66 individuals .  Weight reduction result ed in bone loss at several sites in women consuming 1 g Ca/day and was mitigated with higher calcium intake at 1.7 g/day . INTRODUCTION Bone loss is associated with weight loss in obese postmenopausal women and can be prevented with calcium ( Ca ) supplementation . However , because bone loss caused by weight loss may be greater in overweight than obese women , it is not clear whether Ca supplementation is also beneficial in overweight women . MATERIAL S AND METHODS We assessed the influence of caloric restriction at two levels of Ca intake on BMD and BMC in 66 overweight postmenopausal women ( age , 61 + /- 6 years ; body mass index , 27.0 + /- 1.8 kg/m2 ) . Subjects completed either a 6-month energy-restricted diet ( WL , n = 47 ) and lost 9.3 + /- 3.9 % weight or maintained weight ( WM ; 1 g Ca/day , n = 19 ) . Participants in the WL group were r and omly assigned to either normal ( 1 g/day ; WL NL-Ca ) or high ( 1.7 g/day ; WL Hi-Ca ) Ca intake .  Regional BMD and BMC were measured at baseline and after 6 months . RESULTS During normal Ca intake , trochanter BMD and BMC and total spine BMD were decreased more in WL than WM women ( p < 0.05 ) . The WL NL-Ca group lost more trochanter BMD ( -4.2 + /- 4.1 % ) and BMC ( -4.8 + /- 7.1 % ) than the WL Hi-Ca group ( -1.4 + /- 5.6 % and -1.1 + /- 8.1 % , respectively ; p < 0.05 ) . There were no significant changes in BMD or BMC at the femoral neck in any group . Weight loss correlated with trochanter BMD loss ( r = 0.687 , p < 0.001 ) in the WL NL-Ca group . CONCLUSION Despite an intake of 1 g Ca/day , bone loss occurred at some sites because of weight loss . Calcium intake of 1.7 g/day will minimize bone loss during weight loss in postmenopausal overweight women
Meta- analysis of BMI values at end of trial showed no statistically significant difference in BMI change by use of 25[OH]D supplementation .
Based on existing published trials , oral 25[OH]D supplementation does not significantly impact BMI change
The impact of 25-hydroxyvitamin D ( 25[OH]D ) supplementation on weight change remains controversial .
The objective of this study was to summarize the effects of 25[OH]D supplementation ( cholecalciferol or ergocalciferol ) on BMI change through a meta- analysis of published clinical trials .