Therefore , although the overall effect of metformin on the concentration of serum Hcy was neutral , our results suggested that metformin could increase the concentration of Hcy when exogenous B-group vitamins or folic acid supplementation was not given
The aim of this systematic review is to assess whether metformin could change the concentration of serum homocysteine ( Hcy ) with and without simultaneous supplementation of B-group vitamins or folic acid .
Inadequacy of initiating rosuvastatin then metformin on biochemical profile of polycystic ovarian syndrome patients
Background Polycystic ovary syndrome ( PCOS ) afflicts at least 5 % of women . Both metformin and statin have been used as methods to ameliorate symptoms and improve prognosis . Aim To test the efficacy of concomitant usage of metformin and statins in PCOS patients . Material s and methods This is a prospect i ve , r and omized , double-blinded , placebo controlled study . 37 patients received rosuvastatin ( 10 mg/day ) for a period of 3 months , then the patients were r and omly allocated to one of two groups : the first group ( or intervention group ) received rosuvastatin ( 10 mg/day ) plus metformin ( 850 mg twice daily after meals ) , and the second group ( referred to as control group hereafter ) received rosuvastatin ( 10 mg/day ) plus placebo for a period of 3 months .  Biochemical and clinical data were collected at each time point . Results There were no significant differences between the intervention and control groups for baseline lipid profile ( LDL , HDL , triglycerides , total cholesterol ) , CRP , homocysteine , DHEAS , testosterone and insulin ( p > 0.05 for all variables ) . There were no significant differences in lipid profile , CRP , homocysteine , DHEAS , testosterone and insulin between the intervention and placebo groups at 3 and 6 months after treatment ( p > 0.05 for all ) . Significant differences in the outcome variables of LDL , total cholesterol and FBS emerged within the intervention group , with significantly higher levels at 6 months compared to 3 months . We also did not find any significant group differences in unit change of the outcome variables between baseline and 3 months . Conclusions We found that the combination of statin and metformin has no advantage in PCOS management . In fact , the increase of LDL , total cholesterol and FBS within the intervention group warrants re assessment of current regimens to avoid any patient harm
Therefore , although the overall effect of metformin on the concentration of serum Hcy was neutral , our results suggested that metformin could increase the concentration of Hcy when exogenous B-group vitamins or folic acid supplementation was not given
The aim of this systematic review is to assess whether metformin could change the concentration of serum homocysteine ( Hcy ) with and without simultaneous supplementation of B-group vitamins or folic acid .