Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .
The Effects of Topical Agent (Kelo-Cote or Contractubex) Massage on the Thickness of Post-Burn Scar Tissue Formed in Rats
Background We conducted an experimental study to compare the effect of massage using topical agents ( Kelo-cote or Contractubex ) on scar formation by massaging the healed burn wound on the dorsal area of Sprague-Dawley ( SD ) rats . Methods Four areas of second degree contact burn were made on the dorsal area of each of 15 SD rats , using a soldering iron 15 mm in diameter . After gross epithelialization in the defect , 15 SD rats were r and omly divided into four groups : the Kelo-cote group , Contractubex group , Vaseline group , and control group . Rats in three of the groups ( all but the Control group ) were massaged twice per day for 5 minutes each day , while those in the Control group were left unattended . For histologic analysis , we performed a biopsy and evaluated the thickness of scar tissue . Results In the Kelo-cote and Contractubex groups , scar tissue thicknesses showed a significant decrease , compared with the Vaseline and control groups . However , no significant differences were observed between the Kelo-cote and Contractubex groups . In the Vaseline group , scar tissue thicknesses showed a significant decrease , compared with the control groups . Conclusions The findings of this study suggest that massage using a topical agent is helpful in the prevention of scar formation and that massage only with lubricant ( no use of a topical agent ) also has a considerable effect , although not as much as the use of a topical agent . Thus , we recommend massage with a topical agent on the post-burn scar as an effective method for decreasing the scar thickness
Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .