No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .
A Novel Thermodynamic Treatment for Meibomian Gland Dysfunction
Purpose : To evaluate a novel thermodynamic treatment for obstructive meibomian gl and dysfunction ( MGD ) . Material s and Methods : Fourteen adult subjects ( 10 females , 4 males , mean age = 54.2 ± 9.6 yr ) were recruited in a multi-center , feasibility clinical trial in Durham and Cary , North Carolina and Boston , Massachusetts . Inclusion criteria included : previous diagnosis of moderate to severe dry eye ; dry eye symptoms for at least three months prior ; daily topical lubricant use ; and evidence of meibomian gl and ( MG ) obstruction in the central five gl and s of both eyes lower eyelids . Exclusion criteria included : history of recent acute or chronic ocular inflammation or infection and lid surface abnormalities affecting lid function . The treatment : the device heats the palpebral surface of upper and lower eyelids while simultaneously applying grade d pulsatile pressure to the outer eyelid for 12 min , thereby expressing the MGs during heating . One eye was r and omly selected to undergo additional manual heated expression with another treatment device . Results : The mean MG secretion score , tear break-up time , corneal staining score , number of MGs yielding liquid secretion and symptom scores all improved significantly from baseline to 1 week . This was maintained through the 3-month follow-up . There was no statistically significant difference in any outcome between the automated device treatment only and the additional heated manual expression . Conclusion : The combination of heat applied to the palpebral surface , while simultaneously expressing MGs during a single 12-minute treatment , was effective , in this feasibility study , in treating obstructive MG dysfunction and dry eye signs and symptoms for the 3-month study period
No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .