The associations between BP-lowering treatments and outcomes were not significantly different , irrespective of drug class , except for stroke and heart failure .
AND RELEVANCE Among patients with type 2 diabetes , BP lowering was associated with improved mortality and other clinical outcomes with lower RRs observed among those with baseline BP of 140 mm Hg and greater .
These findings support the use of medications for BP lowering in these patients
IMPORTANCE Lowering blood pressure ( BP ) is widely used to reduce vascular risk in individuals with diabetes .
OBJECTIVE To determine the associations between BP-lowering treatment and vascular disease in type 2 diabetes .
Uniformity of captopril benefit in the SAVE Study: subgroup analysis. Survival and Ventricular Enlargement Study.
The Survival and Ventricular Enlargement ( SAVE ) Study demonstrated that long-term administration of the angiotensin-converting enzyme inhibitor captopril to recent survivors of myocardial infa rct ion with left ventricular dysfunction result ed in a reduction in cardiovascular mortality and morbidity . Analysis of multiple subgroups demonstrated that baseline demographics ( older age ) and clinical characteristics ( such as prior MI , history of diabetes or hypertension ) , that have previously been associated with a higher risk of cardiovascular events , were associated with greater end point event rates in SAVE regardless of therapy assignment at the time of r and omization . The effectiveness of captopril therapy in reducing cardiovascular mortality and morbidity was examined in multiple subgroups . Although not all subgroups provided adequate statistical power , the benefits of captopril therapy were relatively uniform in the SAVE study . This indicates that the benefits were not confined to one particular subgroup and conversely that targeting of captopril therapy should be to the broadest group , as defined by SAVE entry criteria , to result in a reduction in cardiovascular mortality and morbidity
The associations between BP-lowering treatments and outcomes were not significantly different , irrespective of drug class , except for stroke and heart failure .
AND RELEVANCE Among patients with type 2 diabetes , BP lowering was associated with improved mortality and other clinical outcomes with lower RRs observed among those with baseline BP of 140 mm Hg and greater .
These findings support the use of medications for BP lowering in these patients
IMPORTANCE Lowering blood pressure ( BP ) is widely used to reduce vascular risk in individuals with diabetes .
OBJECTIVE To determine the associations between BP-lowering treatment and vascular disease in type 2 diabetes .