Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults , results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters .
This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect
This systematic review aims to evaluate r and omised controlled trials ( RCTs ) investigating the effect of vitamin D supplementation on  endothelial function and inflammation in adults .
Effects of cholecalciferol on functional, biochemical, vascular, and quality of life outcomes in hemodialysis patients.
BACKGROUND AND OBJECTIVES Observational studies suggest that calciferol supplementation may improve laboratory and patient-level outcomes of hemodialysis patients with reduced 25-hydroxyvitamin D [ 25(OH)D ] levels . This r and omized controlled trial examined effects of cholecalciferol supplementation in patients on hemodialysis . DESIGN , SETTING , PARTICIPANTS , & MEASUREMENTS Sixty patients with 25(OH)D levels ≤24 ng/ml ( ≤60 nmol/L ) were r and omized to receive 50,000 IU oral cholecalciferol or placebo , once weekly for 8 weeks and then monthly for 4 months . At baseline ( autumn 2011 ) and 6 months , testing evaluated muscle strength , functional capacity , laboratory parameters , pulse wave velocity ( PWV ) , and health-related quality of life ( HRQOL ) using the Kidney Disease Quality of Life-36 survey . RESULTS Patients were well matched by treatment allocation . Median age was 62 years ( range , 20 - 86 ) , 52 % were women , 55 % had a history of diabetes , and mean serum 25(OH)D was 17±5 ng/ml ( 43±13 nmol/L ) . Patients were assessed over 6 months by repeated- measures ANOVA . Patients allocated to cholecalciferol had significantly higher values of 25(OH)D ( P<0.001 ) , 1,25-dihydroxyvitamin D ( P=0.04 ) , and tartrate-resistant acid phosphatase-5b ) ( P=0.04 ) and a greater reduction in phosphorus values ( P=0.03 ) than placebo-treated  patients Values of serum calcium , intact parathyroid hormone , and episodes of hypercalcemia and hyperphosphatemia did not differ significantly between the groups . No significant differences were detected in muscle strength , functional capacity , PWV , or HRQOL . CONCLUSIONS In this r and omized controlled trial , patients supplemented with cholecalciferol  had higher 25(OH)D , 1,25-dihydroxyvitamin D , and tartrate-resistant acid phosphatase-5b levels , without increased calcium or phosphorus values . However , no effects were detected in muscle strength , functional capacity , PWV , or HRQOL
Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults , results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters .
This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect
This systematic review aims to evaluate r and omised controlled trials ( RCTs ) investigating the effect of vitamin D supplementation on  endothelial function and inflammation in adults .