Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .
Dynamics of circulating microparticles in obesity after weight loss
Abstract A definitive relationship between adiposity and MP production is yet to be demonstrated . The aim of our study was to prospect ively evaluate the levels of microparticles ( MP ) in a group of 20 III degree obese patients before and after weight loss .  Plasma levels of annexin V-MP , endothelial-derived MP , platelet-derived MP ( CD61 + and P-Selectin+ ) , leukocyte-derived MP , tissue factor-bearing ( TF+ ) and CD36+MP  were prospect ively measured in 20 patients with III degree obesity ( BMI ≥ 40 kg/m2 ) before ( T0 ) and 3 ( T3 ) and 12 ( T12 ) months after sleeve gastrectomy ( SLG ) . Obese patients had lost 18 % of their body weight at T3 and 41 % at T12 . We find that considering all MP , except for endothelial-derived MP , which had significantly decreased at T3 , all MP subtypes had significantly decreased at T12 . At T12 , subjects showed a higher median level of all types of MP , except endothelial-derived MP , compared to T3 , but without a statistically significant difference . The percentages of reduction of all the MP were significantly correlated with the percentage of reduction of BMI . The reductions of leukocyte-derived , TF+ and CD36+MP were significantly correlated with the reduction of leptin . Moreover , the reductions of leukocyte-derived and CD36+MP were significantly correlated with hs-CRP decrease . The decrease of BMI post-SLG in morbid obesity was matched with a decrease of circulating MP of endothelial , platelet , leukocyte origin , TF+ and CD36 + . A trend of slight increase in all MP subtypes , except endothelial-derived , was detected 12 months after gastrectomy , indicating a possible underlying slow low- grade inflammatory/hypercoagulability state from adipose tissue before the potential overt weight gain
Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .