RESULTS Weight loss was associated with a decline in CRP level .
Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level
BACKGROUND Several studies suggest that weight loss reduces C-reactive protein ( CRP ) level ; however , the consistency and magnitude of this effect has not been well characterized .
Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level .
Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects.
Elevated levels of serum amyloid A ( SAA ) and C-reactive protein ( CRP ) have been associated with increased cardiovascular risk . Although levels of CRP decrease with weight loss , it is not known whether SAA decreases with weight loss or whether dietary macronutrient composition affects levels of either SAA or CRP . SAA and CRP levels were measured retrospectively on baseline and 3-month plasma sample s from 41 obese ( mean body mass index 33.63 + /- 1.86 kg/m2 ) women completing a r and omized trial comparing a low-fat diet ( n = 19 ) and a very low-carbohydrate diet ( n = 22 ) . For the 41 participants , there were significant decreases from baseline to 3 months in both LogSAA ( P = 0.049 ) and LogCRP ( P = 0.035 ) . The very low-carbohydrate dieters had a significantly greater decrease in LogSAA ( P = 0.04 ) , but their weight loss also was significantly greater ( -7.6 + /- 3.2 vs. -4.3 + /- 3.5 kg , P < 0.01 ) . In this study , the decreases in inflammatory markers correlated significantly with weight loss ( r = 0.44 , P = 0.004 vs. LogSAA and r = 0.35 , P = 0.03 vs. LogCRP ) . Also , change in LogSAA correlated with change in insulin resistance ( r = 0.35 , P = 0.03 ) . Thus , in otherwise healthy , obese women , weight loss was associated with significant decreases in both SAA and CRP . These effects were proportional to the amount of weight lost but independent of dietary macronutrient composition
RESULTS Weight loss was associated with a decline in CRP level .
Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level
BACKGROUND Several studies suggest that weight loss reduces C-reactive protein ( CRP ) level ; however , the consistency and magnitude of this effect has not been well characterized .
Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level .