Quality -of-life scores ( Piper Fatigue Scale MD 0.73 , 95 % CI 0.29 to 1.18 ; I2 = 0 % ; studies = 3 ) and peak oxygen consumption ( MD 2.77 mL/kg/min , 95 % CI -0.89 to 6.43 ; I2 = 36 % ; 2 studies , 32 participants ) were associated with very low- quality evidence , and we remain uncertain about the role of intravenous iron for these metrics .
Current evidence is insufficient to show benefit of intravenous iron preparations for the treatment of non-anaemic iron deficiency across a variety of patient population s , beyond stating that it may result in a small , clinical ly insignificant increase in haemoglobin concentration .
BACKGROUND Iron deficiency is one of the most common nutritional deficiencies , and has a number of physiological manifestations .
Early , or non-anaemic iron deficiency can result in fatigue and diminished exercise capacity .
Oral iron preparations have a high incidence of intolerable side effects , and are ineffective in certain forms of iron deficiency .
Consequently , intravenous iron preparations are increasingly used in the treatment of non-anaemic iron deficiency .
The newer , more stable iron preparations in particular purport to have a lower incidence of side effects , and are now used across a range of different patient population s. OBJECTIVES To assess the effects of intravenous iron therapy in the treatment of adults with non-anaemic iron deficiency .
Associations between non-anaemic iron deficiency and outcomes following surgery for colorectal cancer: An exploratory study of outcomes relevant to prospective observational studies
Iron deficiency is common in colorectal cancer . Despite perioperative guidelines advocating for the correction of non-anaemic iron deficiency prior to major surgery , the impact of this pathology on postoperative outcome is unclear . We conducted a single-centre , historical cohort study of 141 elective resections for colorectal cancer . We stratified non-anaemic patients into iron deficient and iron replete groups , and collected data on baseline characteristics , preoperative laboratory results , intraoperative events and postoperative outcomes . As this study was an exploratory work for future research , a P-value of 0.25 was considered relevant . Patients in the deficient group demonstrated lower baseline ferritin ( median ( interquartile range , IQR ) 76 ( 41–141 ) µg/L versus 207 ( 140–334 ) µg/L , P < 0.001 ) and transferrin saturation ( mean ( st and ard deviation , SD ) 18 % ( 8 % ) versus 32 % ( 12 % ) , P < 0.001 ) than those in the replete group , and lower starting haemoglobin ( mean ( SD ) 138 ( 10 ) g/L versus 144 ( 12 ) g/L , P = 0.01 ) . The deficient group had increased re-admission ( 25 % ( 24 % ) versus 4 % ( 11 % ) , P = 0.15 ) and all-cause infection ( 25 % ( 24 % ) versus 5 % ( 14 % ) , P = 0.24 ) . A decrease of two days in days alive and out of hospital at postoperative day 90 was seen in the deficient group on univariate analysis ( median ( IQR ) 81 ( 75–84 ) versus 83 ( 78–84 ) , P = 0.25 ) . This reduced to 1.24 days in multivariate adjusted quantile regression analysis ( P = 0.22 ) . Days alive and out of hospital at day 90 , postoperative re-admission and postoperative infection may be meaningful outcome measures for future prospect i ve observational work examining non-anaemic iron deficiency in patients undergoing major surgery for colorectal cancer
Quality -of-life scores ( Piper Fatigue Scale MD 0.73 , 95 % CI 0.29 to 1.18 ; I2 = 0 % ; studies = 3 ) and peak oxygen consumption ( MD 2.77 mL/kg/min , 95 % CI -0.89 to 6.43 ; I2 = 36 % ; 2 studies , 32 participants ) were associated with very low- quality evidence , and we remain uncertain about the role of intravenous iron for these metrics .
Current evidence is insufficient to show benefit of intravenous iron preparations for the treatment of non-anaemic iron deficiency across a variety of patient population s , beyond stating that it may result in a small , clinical ly insignificant increase in haemoglobin concentration .
BACKGROUND Iron deficiency is one of the most common nutritional deficiencies , and has a number of physiological manifestations .
Early , or non-anaemic iron deficiency can result in fatigue and diminished exercise capacity .
Oral iron preparations have a high incidence of intolerable side effects , and are ineffective in certain forms of iron deficiency .
Consequently , intravenous iron preparations are increasingly used in the treatment of non-anaemic iron deficiency .
The newer , more stable iron preparations in particular purport to have a lower incidence of side effects , and are now used across a range of different patient population s. OBJECTIVES To assess the effects of intravenous iron therapy in the treatment of adults with non-anaemic iron deficiency .