In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes.
We conducted a r and omised single centre double blind cross over clinical trial to investigate the effects of a herbal tea containing Salacia reticulata ( Kothala Himbutu tea ) in patients with type II diabetes mellitus . Fifty-one patients with type II diabetes mellitus for longer than 6 months and with evidence of stable glycaemic control over the preceding 6 months ( as assessed by HbA1C ) participated in the study . They were r and omised to receive a st and ard preparation of Kothala Himbutu tea for 3 months followed by placebo in similar tea bags for a further 3 months ( n = 28 ) or in reverse order ( n = 23 ) . All patients received detailed advice on diet , exercise and lifestyle modification . HbA1C was measured at recruitment , at 3 months and on completion of the study at 6 months . Liver and renal functions were assessed biochemically at baseline , at 3 and 6 months and adverse events were recorded . There were no significant differences between the two groups in age , body mass index , male/female ratio , glycaemic control and baseline laboratory tests . All patients completed both arms of the trial . The HbA1C at the end of drug treatment was significantly lower than after treatment with placebo ( 6.29 + /- S.D. 1.02 versus 6.65 + /- S.D. 1.04 ; P = 0.008 ) . A statistically significant fall in HBA1c was seen with the active drug compared to a rise in HbA1C with the placebo group ( 0 . 54 + /- S.D. 0.93 ) versus -0.3 + /-S.D. 1.05 ; P < 0.001 . The daily mean dose of Glibenclamide fell by 1.89 ( S.D. 6.2 ) mg in the drug treated group but rose by 2.25 mg in the placebo treated group ( P = 0.07 ) . The differences in the metformin dose were not significantly significant in the two groups . We conclude that Kothala Himbutu tea is an effective and safe treatment for type 2 diabetes
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .