SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .
Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
Background Cocaine dependence is a major public health problem with no available robustly effective pharmacotherapy . This study ’s aim was to determine if treatment with sertraline ( SERT ) or SERT plus gabapentin ( GBP ) improved treatment retention , depressive symptoms , and /or cocaine use . Methods Depressed cocaine-dependent patients ( N = 99 ) were enrolled in a 12-week , double-blind , r and omized , placebo (PLA)-controlled , clinical trial and placed in research beds at a residential treatment facility ( Recovery Centers of Arkansas ) . They were r and omized by depressive symptom severity and inducted onto 1 of the following while residing at the Recovery Centers of Arkansas : SERT ( 200 mg/d ) , SERT ( 200 mg/d ) plus GBP ( 1200 mg/d ) , or PLA . Participants transferred to outpatient treatment at the start of their third week , continued receiving study medications or PLA ( weeks 3–12 ) , and participated in weekly individual cognitive behavioral therapy . Compliance was facilitated through the use of contingency management procedures . Supervised urine sample s were obtained thrice weekly and self-reported mood weekly . At the end of 12 weeks , participants were tapered off the study medication over 5 days and referred to a local treatment program . Results Sertraline , but not SERT plus GBP , showed a significantly lower overall percentage of cocaine-positive urine sample s compared with that of PLA . A significantly greater percentage of participants experienced relapse in the PLA group ( 88.9 % ) compared with that of the SERT group ( 65.2 % ) . Hamilton depression ratings decreased significantly over time regardless of the treatment group . Retention in treatment did not differ significantly between the treatment groups . Conclusions Sertraline plus GBP may not be superior to SERT alone in delaying relapse among abstinent cocaine-dependent individuals undergoing cognitive behavioral therapy
SSRIs significantly increase the risk of both serious and non-serious adverse events .
The potential small beneficial effects seem to be outweighed by harmful effects .
Background The evidence on selective serotonin reuptake inhibitors ( SSRIs ) for major depressive disorder is unclear .
Methods Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo , ‘ active ’ placebo , or no intervention in adult participants with major depressive disorder .