The current meta- analysis revealed that probiotic supplementation may result in increasing TAC and lowering MDA , which improve antioxidant status .
Previous studies have supposed that probiotic supplementation led to a positive effect on different health outcomes .
Furthermore , several studies indicated that probiotics supplementation improved antioxidant status , while some studies did not indicate these effects .
Hence , current systematic review and meta- analysis study was conducted to determine the effect of probiotic supplementation on some oxidative stress biomarkers  among adult subjects .
Effects of Probiotic Supplementation on Oxidative Stress Indices in Women with Rheumatoid Arthritis: A Randomized Double-Blind Clinical Trial
Objective : Rheumatoid arthritis ( RA ) is an autoimmune inflammatory disease that causes great pain and disability and increasing oxidative stress in patients . The objective of the present study was to evaluate the effects of probiotics — live microorganisms with many health benefits , including antioxidant properties — on oxidative stress indices of patients with RA . This study is a secondary analysis from a previously published study Methods : In a r and omized double-blind placebo-controlled clinical trial , 46 patients with RA were assigned to one of two groups ; patients in the probiotic group received a daily capsule containing 108 colony forming units ( CFUs ) of Lactobacillus casei 01 ( L. casei 01 ) , while those in the placebo group took identical capsules containing maltodextrin , for 8 weeks . In the baseline and at the end of the study , anxiety , physical activity levels , and dietary intakes were assessed . Anthropometric parameters , serum malondialdehyde ( MDA ) , total antioxidant capacity ( TAC ) , erythrocyte superoxide dismutase ( SOD ) , glutathione peroxidase ( GPx ) , and catalase ( CAT ) activities were measured . Results : There was no significant difference between the two groups for demographic characteristics , anthropometric parameters , physical activity , anxiety levels , or dietary intakes , throughout the course of the study . No significant within- and between-group differences were observed for MDA , TAC , or CAT . SOD activity decreased only in the probiotic group and GPx activity decreased in both study groups ( p < 0.05 ) ; however , no significant between-group difference was found for these enzymes activities at the end of the study ( p > 0.05 ) . Conclusion : No significant effect of L. casei 01 supplementation was observed on the oxidative status of patients with RA , compared to placebo
The current meta- analysis revealed that probiotic supplementation may result in increasing TAC and lowering MDA , which improve antioxidant status .
Previous studies have supposed that probiotic supplementation led to a positive effect on different health outcomes .
Furthermore , several studies indicated that probiotics supplementation improved antioxidant status , while some studies did not indicate these effects .
Hence , current systematic review and meta- analysis study was conducted to determine the effect of probiotic supplementation on some oxidative stress biomarkers  among adult subjects .