The vast majority of studies reported inverse associations between 25(OH)D concentration and all-cause mortality .
This association appeared to be non-linear , with progressively lower mortality with increasing 25(OH)D up to a point , beyond which there was no further decrease .
There is moderate evidence that vitamin D status is inversely associated with cancer mortality and death due to respiratory diseases , while for cardiovascular mortality , there is weak evidence of an association in observational studies , which is not supported by the data from intervention or Mendelian r and omization studies .
Epidemiological evidence suggests that vitamin D deficiency is associated with increased mortality , but it is unclear whether this is explained by reverse causation , and if there are specific causes of death for which vitamin D might be important .
Low Serum Vitamin D is Not Associated with an Increase in Mortality in Oldest Old Subjects: The Octabaix Three-Year Follow-Up Study
Background : Poor vitamin D status , i.e. low serum levels of 25-hydroxyvitamin D [ 25(OH)D ] , is common in the general population . Prospect i ve epidemiologic data on the association between vitamin D and mortality in oldest old subjects are limited . Objective : This study aim ed to determine whether 25(OH)D concentrations were prospect ively and independently associated with cardiovascular disease ( CVD ) mortality and all-cause mortality in oldest old subjects . Methods : A total of 312 subjects aged 85 years old at baseline ( Octabaix study ) were followed for 3 years . Sociodemographic and overall geriatric assessment data were collected . Serum 25(OH)D concentrations were used to assess vitamin D status . Data on overall and cardiovascular mortality were collected . Results : The mean serum 25(OH)D levels were 28 ± 30 ng/ml . During the follow-up period , 58 subjects ( 18.5 % ) died . Twenty-five of the deaths ( 8 % ) were related to CVD . There were no differences in mortality rates according to the different quartiles of vitamin D ( p = 0.41 for total mortality and p = 0.86 for CVD mortality ) . Conclusion : In community-dwelling oldest old subjects  , serum 25(OH)D levels were not associated with overall or CVD mortality after a 3-year follow-up
The vast majority of studies reported inverse associations between 25(OH)D concentration and all-cause mortality .
This association appeared to be non-linear , with progressively lower mortality with increasing 25(OH)D up to a point , beyond which there was no further decrease .
There is moderate evidence that vitamin D status is inversely associated with cancer mortality and death due to respiratory diseases , while for cardiovascular mortality , there is weak evidence of an association in observational studies , which is not supported by the data from intervention or Mendelian r and omization studies .
Epidemiological evidence suggests that vitamin D deficiency is associated with increased mortality , but it is unclear whether this is explained by reverse causation , and if there are specific causes of death for which vitamin D might be important .