Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .
Antidepressant use in nonmajor depression: secondary analysis of a program to encourage active, rewarding lives for seniors (PEARLS), a randomized controlled trial in older adults from 2000 to 2003.
BACKGROUND It is estimated that major depressive disorder affects 0.9 % of community-dwelling older adults in the United States . However , as many as 18 % of older US adults reportedly suffer from depressive symptoms that do not necessarily fit the criteria for major depressive disorder ( eg , dysthmia , minor depression ) . OBJECTIVES The goals of this study were to describe patterns of antidepressant medication use in older adults with dysthymia or minor depression and to examine factors associated with the use of antidepressants at baseline . METHODS This was a secondary analysis using cross-sectional data collected during a r and omized controlled trial conducted from 2000 through 2003 . It involved community senior service agencies and in-home visits in Seattle , Washington . Adults aged > or=60 years who had minor depression or dysthymia and were receiving services through community senior service agencies or living in senior public housing were included . Study participants were classified as users or nonusers of antidepressants . Prescription medication use in the past 2 weeks was assessed at baseline and 6 and 12 months . Medication name , dose , and directions were recorded from the medication label . Logistic regression was used to examine variables associated with baseline antidepressant use . RESULTS A total of 138 patients ( mean age , 73.00 years ) were included ; the majority of study participants were female ( 779.00 % ) . Overall , 42.33 % were nonwhite ( 34.3 % black , 4.4 % Asian , 1.5 % American Indian/Alaskan Native , 0.7 % Hispanic , and 1.5 % other ) . At baseline , 36.2 % of study participants ( n = 50 ) were using antidepressants .  Selective serotonin reuptake inhibitors were the most common class of antidepressants , used by 62.00 % , 70.22 % , and 71.11 % of antidepressant users at baseline , 6 , and 12 months , respectively . However ,  nortriptyline  was the most common antidepressant at baseline , taken by 20.00 % of antidepressant users . Use of other prescription medications was associated with antidepressant use at baseline . CONCLUSIONS We found antidepressant use to be low in these relatively poor , community-dwelling , ethnically diverse older adults with dysthymia and minor depression in 2000 through 2003 , with 36.22 % of participants using antidepressants at baseline . Antidepressant users were more likely to be taking other prescription medications than nonusers
Some statistically significant differences between citalopram and other antidepressants for the acute phase treatment of major depression were found in terms of efficacy , tolerability and acceptability .
Citalopram was more efficacious than paroxetine and reboxetine and more acceptable than tricyclics , reboxetine and venlafaxine , however , it seemed to be less efficacious than escitalopram .
BACKGROUND Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode .
Systematic review s have already highlighted some differences in efficacy between second-generation antidepressants .
Citalopram , one of the first selective serotonin reuptake inhibitors ( SSRI ) introduced in the market , is one of these antidepressant drugs that clinicians use for routine depression care .
OBJECTIVES To assess the evidence for the efficacy , acceptability and tolerability of citalopram in comparison with tricyclics , heterocyclics , other SSRIs and other conventional and non-conventional antidepressants in the acute-phase treatment of major depression .