Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .
Effects of a short course of oral phosphate treatment on serum parathyroid hormone (1–84) and biochemical markers of bone turnover: A dose-response study
Summary To investigate the possible use of oral phosphate as an activator of bone remodeling in coherence treatment of osteoporosis , 82 postmenopausal females , aged 50–75 years , were r and omized to treatment with oral phosphate ( 750 , 1500 , or 2550 mg/day ) or placebo for 7 days and followed for 4 months thereafter . All patients had sustained at least one previous fracture of the distal forearm and had a bone mineral content of the contralateral forearm or bone mineral density of the lumbar spine lower than normal mean for age . Urinary phosphate/creatinine ratio increased in a dose-dependent fashion during treatment ( P<0.001 ) , whereas no significant changes were seen in serum phosphate or serum calcium . Serum parathyroid hormone ( PTH ) rose significantly ( P<0.05 ) during treatment to a maximum of 36 and 33 % in the groups receiving 1500 and 2250 mg/day , respectively , whereas serum 1,25-dihydroxycholecalciferol remained unchanged . In the group receiving 1500 mg/day , mean serum osteocalcin was increased in the period from day 1 to day 28 ( P<0.05 ) , but no significant changes were observed in urinary hydroxyproline/creatinine ratio , or serum bone alkaline phosphatase . We conclude that a short course of oral phosphate treatment increases serum PTH considerably . Furthermore , 1500 mg/day but not 2250 mg/day increases serum osteocalcin . No clear biochemical evidence , however , of increased activation of bone remodeling could be demonstrated in either group
Urine calcium excretion rates were consistent with osteoporosis development ; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion .
No study revealed a biologic mechanism functioning at physiological pH. Finally , r and omized studies did not provide evidence for an adverse role of phosphate , milk , and grain foods in osteoporosis .
Conclusions A causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health
Background Modern diets have been suggested to increase systemic acid load and net acid excretion .
In response , alkaline diets and products are marketed to avoid or counteract this acid , help the body regulate its pH to prevent and cure disease .
The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill 's criteria .