In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .
Impact of time since last caloric intake on blood glucose levels
Blood glucose ( BG ) is usually measured after a caloric restriction of at least 8 h ; however evidence -based recommendations for the duration of a fasting status are missing . Here we analyze the effect of fasting duration on levels of BG to determine the minimal fasting duration to achieve comparable BG levels to conventional fasting measurements . We used data of a cross-sectional study on primary care patients , performed in October 2005 . We included 28,024 individuals ( age-range 18–99 years ; 63 % women ) without known diabetes mellitus and without missing data for BG and fasting status . We computed general linear models , adjusting for age , sex , time of blood withdrawal , systolic blood pressure , waist circumference , total- and HDL-cholesterol , physical activity , smoking , intake of beta-blocker and alcohol . We tested the intra-individual variability with respect to fasting status . Overall , the mean BG differed only slightly between individuals fasting ≥8 h and those fasting < 8 h ( men : 5.1 ± 0.8 mmol/L versus 5.2 ± 1.2 mmol/L ; women : 4.9 ± 0.7 mmol/L , 5.0 ± 1.0 mmol/L ) . After 3 h of fasting differences of BG diminished in men to −0.08 mmol/L ( 95%-CI : −0.15 ; −0.01 mmol/L ) , in women to −0.07 mmol/L ( −0.12 ; −0.03 mmol/L ) compared to individuals fasting ≥8 h. Noteworthy , age , time of day of blood withdrawal , physical activity , and intake of hard liquor influenced BG levels considerably . Our data challenge the necessity for a fasting duration of ≥8 h when measuring blood glucose , suggesting a r and om sampling or a fasting duration of 3 h as sufficient . Rather , our study indicates that essentially more effort on the assessment of additional external/internal factors on BG levels is necessary
In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .