Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .
The efficacy and tolerability of once-daily controlled-release trazodone for depressed mood, anxiety, insomnia, and suicidality in major depressive disorder.
Trazodone Contramid(R ) once-a-day ( TzCOAD ) is a reformulation of trazodone hydrochloride that controls the release of trazodone over 24 hours . A st and ard effect size analysis ( Cohen 's d ) determined which items of the 17-item Hamilton Depression Rating Scale ( HAMD-17 ) and the Montgomery-Asberg Depression Rating Scale ( MADRS ) showed the greatest improvement in patients with major depressive disorder ( MDD ) , following up to 8 weeks of therapy with TzCOAD . An additional insomnia analysis assessed whether the efficacy of TzCOAD is influenced by improvements in insomnia or baseline severity of insomnia . The analyses used data from a r and omized study of 412 patients receiving 150 - 375 mg TzCOAD ( N = 206 ) or placebo ( N = 206 ) . The results of the Cohen 's d analysis on the modified intent-to-treat population ( LOCF ) showed HAMD items with the greatest improvement were insomnia items ( middle ( -0.35 ) , late ( -0.24 ) ) , feelings of guilt ( -0.24 ) , and depressed mood ( -0.23 ) ; for MADRS items they were reduced sleep ( -0.31 ) , inner tension ( -0.22 ) , reported sadness ( -0.21 ) , and suicidal thoughts ( -0.21 ) . An analysis of covariance showed no significant interaction between improvements in the HAMD Bech-6 core symptoms of depression and the baseline MADRS reduced sleep item or early changes in the HAMD-17 sleep disturbance factor . These results suggest that the antidepressant efficacy was independent of the baseline severity of insomnia and of the improvement in insomnia . Overall , the results eluci date the efficacy components and tolerability characteristics previously demonstrated for TzCOAD monotherapy for patients with MDD at the recommended daily dose of 300 mg
Conclusions : According to the published literature , the clinimetric properties of HAM-D6 are superior to those of both the HAM-D17 and MADRS .
Background : In a study aim ed at identifying the items carrying information regarding the global severity of depression , the 6-item Hamilton Depression Rating Scale ( HAM-D6 ) was derived from the original 17-item version of the scale ( HAM-D17 ) .
Since then , the HAM-D6 has been used in a wide range of clinical studies .
We now provide a systematic review of the clinimetric properties of HAM-D6 in comparison with those of HAM-D17 and the Montgomery Asberg Depression Rating Scale ( MADRS ) .