Conclusions : International differences in prescriber behaviour may influence , and in turn be influenced by , the conduct of clinical trials .
Objective : International differences are thought to exist in dosages used by clinicians treating mood disorders .
This study examined international dosage differences in antidepressant clinical trials , using a data base formed and maintained as a component of a Cochrane review of comparative clinical trials of fluoxetine .
The efficacy and acceptability of amineptine versus fluoxetine in major depression
The temporal dimension , particularly anticipation , appears to he a very important component in the underst and ing of depressed patients . In a 90-day multieentre study , the efficacy and acceptability of amineptine and fluoxetine were compared in 169 patients with major depression . Comparison of the two antidepressants was bused on double-blind methods , after r and om allocation of the treatments between two parallel groups . The two drugs did not differ over the whole course of the study , but the improvement in scores on day 4 was globally more marked in the amineptine than the fluoxetine group . Intragroup analysis showed that amineptine was significantly superior to fluoxctine on the retardation pole of the mood , anxiety , retardation , danger scale . The positive effect of amineptine on anticipation may enable the depressed patient to make plans for the future . Anticipation may be a key dimension to be more precisely explored in specific psychopharmacological protocol s with antidepressants
Conclusions : International differences in prescriber behaviour may influence , and in turn be influenced by , the conduct of clinical trials .
Objective : International differences are thought to exist in dosages used by clinicians treating mood disorders .
This study examined international dosage differences in antidepressant clinical trials , using a data base formed and maintained as a component of a Cochrane review of comparative clinical trials of fluoxetine .