Further data on specificity comes from electrophysiological studies reporting that  NF effectively changes brain activity patterns .
No safety issues have emerged from clinical trials and NF seems to be well tolerated and accepted .
Follow-up studies support long-term effects of NF .
In conclusion , NF is a valid option for the treatment for ADHD , but further evidence is required to guide its use
Summary Neurofeedback ( NF ) is a training to enhance self-regulatory capacity over brain activity patterns and consequently over brain mental states .
Recent findings suggest that NF is a promising alternative for the treatment of  attention-deficit/hyperactivity disorder ( ADHD ) .
DOTA derivatives for site-specific biomolecule-modification via click chemistry: synthesis and comparison of reaction characteristics.
Due to the high stability of its complexes with many M(2 + ) and M(3+)-ions , DOTA ( 1,4,7,10-tetraazacyclododecane-N , N',N″,N‴-tetraacetic acid ) is the most commonly used chelator for the derivatization and radiolabeling of bioactive molecules . Most of the currently used DOTA derivatives comprise amine-reactive functionalities , limiting their application to the derivatization of fully protected molecules or otherwise result ing in r and omly distributed conjugation sites of undefined number . Click chemistry reactions are a valuable alternative to this unspecific conjugation as they proceed efficiently and chemoselectively under mild conditions allowing a site-specific derivatization of unprotected biomolecules . In this work , we describe straightforward syntheses of DOTA derivatives containing thiol , maleimide , aminooxy , aldehyde , alkyne , and azide functionalities , amenable to the currently most often used click chemistry reactions . Furthermore , the efficiency of the respective click reactions introducing DOTA into bioactive molecules was investigated . For each of the synthesized DOTA synthons , the site-specific and efficient conjugation to Tyr(3)-octreotate could be shown . Among these , the addition and oxime formation reactions proceeded fast and without side reactions , giving the products in high yields of 64 - 83 % after purification . The copper-catalyzed triazole formation reactions produced some side-products , giving the desired products in lower , but still reasonable overall yields of 19 - 25 % . All synthesized peptide-DOTA-conjugates were labeled with (68)Ga in high radiochemical yields of 96 - 99 % and high specific activities providing compounds of high purity , demonstrating the applicability of all synthons for biomolecule modification and subsequent radiolabeling
Further data on specificity comes from electrophysiological studies reporting that  NF effectively changes brain activity patterns .
No safety issues have emerged from clinical trials and NF seems to be well tolerated and accepted .
Follow-up studies support long-term effects of NF .
In conclusion , NF is a valid option for the treatment for ADHD , but further evidence is required to guide its use
Summary Neurofeedback ( NF ) is a training to enhance self-regulatory capacity over brain activity patterns and consequently over brain mental states .
Recent findings suggest that NF is a promising alternative for the treatment of  attention-deficit/hyperactivity disorder ( ADHD ) .