This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
Consumption of vitamin D-fortified yogurt drink increased leptin and ghrelin levels but reduced leptin to ghrelin ratio in type 2 diabetes patients: a single blind randomized controlled trial
Purpose This study aim ed to evaluate the effect of daily consumption of vitamin D-fortified yogurt drink ( doogh ) in comparison with plain doogh on appetite-regulating hormones including leptin and ghrelin in type 2 diabetes ( T2D ) patients . Methods In a single blind r and omized clinical trial , subjects with T2D were r and omly allocated to one of the two groups and received either vitamin D3-fortified doogh ( FD ; containing 170 mg calcium and 500 IU/250 mL , n2 = 50 ) or plain doogh ( PD ; containing 170 mg calcium and no vitamin D/250 mL , n1 = 50 ) twice a day for 12 weeks . Leptin and ghrelin were evaluated at the beginning and after 12 weeks of intervention . Results The intervention result ed in a significant improvement of circulating 25(OH)D , fasting glucose , Quantitative Insulin Check Index ( QUICKI ) , hs-CRP , in FD compared with PD group . A significant rise in both serum leptin ( + 1.3 ± 7.2 mg/L ; p = 0.013 ) and ghrelin ( 10.1 ± 26.1 ng/L ; p = 0.012 ) was observed in FD group . A between-group difference for ghrelin changes ( p = 0.029 ) remained significant after adjusting for changes QUICKI ( p = 0.039 ) , body mass index ( p = 0.034 ) and hs-CRP ( p = 0.022 ) . Despite an increase in both leptin and ghrelin , leptin to ghrelin ( L/G ) ratio actually decreased in FD . Changes of L/G ratio showed a significant between-group difference ( p = 0.036 ) , which remained significant even after adjusting for changes of hs-CRP ( p = 0.028 ) and fat mass ( p = 0.047 ) but disappeared after adjusting for changes of QUICKI ( p = 0.42 ) . Conclusions Daily intake of vitamin D-fortified doogh may increase circulating leptin and ghrelin but L/G ratio may actually decrease . Our results suggest that improving vitamin D may result in an improvement in insulin sensitivity which may finally regulate beneficially appetite hormones . Further studies with adequate power are needed to confirm the results
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .