Conclusion : Probiotic treatment or supplementation is a promising therapeutic method for NAFLD
Background : Nonalcoholic fatty liver disease ( NAFLD ) has become prevalent in recent decades , especially in developed countries , and approaches for the prevention and treatment of NAFLD are not clear .
The aim of this research was to analyze and summarize r and omized controlled trials that investigated the effects of probiotics on NAFLD .
Probiotics administration following sleeve gastrectomy surgery: a randomized double-blind trial
Background : Probiotics are commonly used after bariatric surgery ; however , uncertainty remains regarding their efficacy . Our aim was to compare the effect of probiotics vs placebo on hepatic , inflammatory and clinical outcomes following  laparoscopic sleeve gastrectomy ( LSG ) . Methods : This r and omized , double-blind , placebo-controlled , trial of 6-month treatment with probiotics ( Bio-25 ; Supherb ) vs placebo and 6 months of additional follow-up was conducted among 100 morbidly obese nonalcoholic fatty liver disease ( NAFLD ) patients who underwent LSG surgery . The primary outcome was a reduction in liver fat content , measured by abdominal ultrasound , and secondary outcomes were improvement of fibrosis , measured by shear-wave elastography , metabolic and inflammatory parameters , anthropometrics and quality of life ( QOL ) . Fecal sample s were collected and analyzed for microbial composition . Results : One hundred patients ( 60 % women , mean age of 41.9±9.8 years and body mass index of 42.3±4.7 kg m−2 ) were r and omized , 80 % attended the 6-month visit and 77 % completed the 12-month follow-up . Fat content and NAFLD remission rate were similarly reduced in the probiotics and placebo groups at 6 months postsurgery ( −0.9±0.5 vs −0.7±0.4 score ; P=0.059 and 52.5 vs 40 % ; P=0.262 , respectively ) and at 12 months postsurgery . Fibrosis , liver-enzymes , C-reactive protein ( CRP ) , leptin and cytokeratin-18 levels were significantly reduced and QOL significantly improved within groups ( P⩽0.014 for all ) , but not between groups ( P⩾0.173 for all ) at 6 and 12 months postsurgery . Within- sample microbiota diversity ( alpha-diversity ) increased at 6-month postsurgery compared with baseline in both study arms ( P⩽0.008 ) and decreased again at 12 months postsurgery compared with 6 months postsurgery ( P⩽0.004 ) but did not reach baseline values . Conclusions : Probiotics administration does not improve hepatic , inflammatory and clinical outcomes 6- and 12 months post-LSG
Conclusion : Probiotic treatment or supplementation is a promising therapeutic method for NAFLD
Background : Nonalcoholic fatty liver disease ( NAFLD ) has become prevalent in recent decades , especially in developed countries , and approaches for the prevention and treatment of NAFLD are not clear .
The aim of this research was to analyze and summarize r and omized controlled trials that investigated the effects of probiotics on NAFLD .