In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Study of curcumin and genistein interactions with human serum albumin.
Curcumin , the yellow pigment from the rhizoma of Curcuma longa , is a widely studied polyphenolic compound which has a variety of biological activity as anti-inflammatory and antioxidative agent . Genistein one of the flavonoids found in soybean and chickpeas inhibits DNA str and breaks acting as a direct scavenger of reactive oxygen species . Human serum albumin ( HSA ) with high affinity binding sites is a major transporter for delivering several endogenous compounds and drugs in vivo . The aim of this study was to examine the interactions of curcumin and genistein with human serum albumin at physiological conditions , using constant protein concentration and various pigment contents .  FTIR , UV-Visible , CD  and  fluorescence spectroscopic methods were used to analyse drug binding mode , the binding constant and the effects of pigment complexation on HSA stability and conformation . Structural analysis showed that curcumin and genistein bind HSA via polypeptide polar groups with overall binding constants of K(curcumin)=5.5 (+/-0.8)x10(4)M(-1 ) and K(genistein)=2.4 (+/-0.40)x10(4)M(-1 ) . The number of bound pigment ( n ) is 1.33 for curcumin and 1.49 for genistein . The HSA conformation was altered by pigment complexation with reduction of alpha-helix and increase of r and om coil and turn structures suggesting a partial protein unfolding
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .