In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .
Effects of Diet Soda on Gut Hormones in Youths With Diabetes
OBJECTIVE In patients with type 2 diabetes , but not type 1 diabetes , abnormal secretion of incretins in response to oral nutrients has been described . In healthy youths , we recently reported accentuated glucagon-like peptide 1 ( GLP-1 ) secretion in response to a diet soda sweetened with sucralose and acesulfame-K. In this study , we examined the effect of diet soda on gut hormones in youths with diabetes . RESEARCH DESIGN AND METHODS Subjects aged 12–25 years with type 1 diabetes ( n = 9 ) or type 2 diabetes ( n = 10 ) , or healthy control participants ( n = 25 ) drank 240 mL cola-flavored caffeine-free diet soda or carbonated water , followed by a 75-g glucose load , in a r and omized , cross-over design . Glucose , C-peptide , GLP-1 , glucose-dependent insulinotropic peptide ( GIP ) , and peptide Tyr-Tyr ( PYY ) were measured for 180 min . Glucose and GLP-1 have previously been reported for the healthy control subjects . RESULTS GLP-1 area under the curve ( AUC ) was 43 % higher after ingestion of diet soda versus carbonated water in individuals with type 1 diabetes ( P = 0.020 ) , similar to control subjects ( 34 % higher , P = 0.029 ) , but was unaffected by diet soda in patients with type 2 diabetes ( P = 0.92 ) . Glucose , C-peptide , GIP , and PYY AUC were not statistically different between the two conditions in any group . CONCLUSIONS Ingestion of diet soda before a glucose load augmented GLP-1 secretion in type 1 diabetic and control subjects but not type 2 diabetic subjects . GIP and PYY secretion were not affected by diet soda . The clinical significance of this increased GLP-1 secretion , and its absence in youths with type 2 diabetes , needs to be determined
In comparison with the baseline , NNS consumption was not found to increase blood glucose level , and its concentration gradually declined over the course of observation following NNS consumption .
The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participants ’ age , body weight , and diabetic status .
Conclusions NNS consumption was not found to elevate blood glucose level .
Background / objectives Nonnutritive sweeteners ( NNSs ) are zero- or low-calorie alternatives to nutritive sweeteners , such as table sugars .
A systematic review and meta- analysis of r and omized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs .