Pain intensity of chronic non-cancer patients was reduced by cannabinoids consumption , but effect sizes were small .
Efficacy for neuropathic and non-neuropathic pain was similar
There is growing interest in using cannabinoids for chronic pain .
We performed a systematic review and meta- analysis of r and omized controlled trials to evaluate the analgesic efficacy and adverse effects of cannabinoids for chronic non-cancer pain .
Vaporization as a Smokeless Cannabis Delivery System: A Pilot Study
Although cannabis may have potential therapeutic value , inhalation of a combustion product is an undesirable delivery system . The aim of the study was to investigate vaporization using the Volcano ® device as an alternative means of delivery of inhaled Cannabis sativa . Eighteen healthy inpatient subjects enrolled to compare the delivery of cannabinoids by vaporization to marijuana smoked in a st and ard cigarette . One strength ( 1.7 , 3.4 , or 6.8 % tetrahydrocannabinol ( THC ) ) and delivery system was r and omly assigned for each of the 6 study days . Plasma concentrations of Δ‐9‐THC , expired carbon monoxide ( CO ) , physiologic and neuropsychologic effects were the main outcome measures . Peak plasma concentrations and 6‐h area under the plasma concentration – time curve of THC were similar . CO levels were reduced with vaporization . No adverse events occurred . Vaporization of cannabis is a safe and effective mode of delivery of THC . Further trials of clinical effectiveness of cannabis could utilize vaporization as a smokeless delivery system
Pain intensity of chronic non-cancer patients was reduced by cannabinoids consumption , but effect sizes were small .
Efficacy for neuropathic and non-neuropathic pain was similar
There is growing interest in using cannabinoids for chronic pain .
We performed a systematic review and meta- analysis of r and omized controlled trials to evaluate the analgesic efficacy and adverse effects of cannabinoids for chronic non-cancer pain .