Pooled evidence suggested that topical anaesthetic creams ( TAs ) , tramadol , selective serotonin reuptake inhibitors ( SSRIs ) , and phosphodiesterase type 5 inhibitors ( PDE5is ) are more effective at prolonging IELT comparing with placebo .
Conclusions We recommend the initial use of dapoxetine 30 mg OD for PE because it has been tested in largest and better design ed clinical trials rather than it is more effective than the other drugs studied .
TAs and tramadol 50 mg OD can be used as a viable alternative to oral treatment with SSRIs .
PDE5is combined with SSRIs are more effective than SSRIs monotherapy but are also associated with more side effects .
Purpose The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for  premature ejaculation ( PE ) .
Optimum usage of prilocaine‐lidocaine cream in premature ejaculation
Summary . Premature ejaculation is a common male sexual disorder in which orgasm and ejaculation occur before the desired moment . The primary therapeutic approach to premature ejaculation has been behavioural and pharmacotherapy . In this study , we evaluated the efficacy and optimum usage of lidocaine‐prilocaine cream 5 % in preventing premature ejaculation . Forty patients were examined in the study group and r and omized into four groups , each comprising 10 patients . Patients in group 1 applied lidocaine‐prilocaine cream 5 % for 20 min , the patients in group 2 applied it for 30 min , and the patients in group 3 applied the cream for 45 min before sexual contact , with all patients covering the penis with a condom . Patients in the fourth group applied a base cream as placebo . In group 1 , the pre‐ejaculation period increased to 6.71 ± 2.54 min without any adverse effects . In group 2 , although the pre‐ejaculation period increased in four patients up to 8.70 ± 1.70 min , six patients in this group and all patients in group 3 had erection loss because of numbness . In the placebo group , there was no change in their pre‐ejaculation period . Therefore , lidocaine‐prilocaine cream 5 % is effective in premature ejaculation and 20 min of application time before sexual contact is the optimum period
Pooled evidence suggested that topical anaesthetic creams ( TAs ) , tramadol , selective serotonin reuptake inhibitors ( SSRIs ) , and phosphodiesterase type 5 inhibitors ( PDE5is ) are more effective at prolonging IELT comparing with placebo .
Conclusions We recommend the initial use of dapoxetine 30 mg OD for PE because it has been tested in largest and better design ed clinical trials rather than it is more effective than the other drugs studied .
TAs and tramadol 50 mg OD can be used as a viable alternative to oral treatment with SSRIs .
PDE5is combined with SSRIs are more effective than SSRIs monotherapy but are also associated with more side effects .
Purpose The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for  premature ejaculation ( PE ) .