Robust statistically significant effects were found for improved diet , aerobic exercise , alcohol and sodium restriction , and fish oil supplements : mean reductions in systolic blood pressure of 5.0 mmHg [ 95 % confidence interval ( CI ) : 3.1 - 7.0 ] , 4.6 mmHg ( 95 % CI : 2.0 - 7.1 ) , 3.8 mmHg ( 95 % CI : 1.4 - 6.1 ) , 3.6 mmHg ( 95 % CI : 2.5 - 4.6 ) and 2.3 mmHg ( 95 % CI : 0.2 - 4.3 ) , respectively , with corresponding reductions in diastolic blood pressure .
Relaxation significantly reduced blood pressure only when compared with non-intervention controls .
We found no robust evidence of any important effect on blood pressure of potassium , magnesium or calcium supplements .
Available evidence does not support relaxation therapies , calcium , magnesium or potassium supplements to reduce blood pressure
PURPOSE To quantify effectiveness of lifestyle interventions for hypertension .
Combinations of potassium, calcium, and magnesium supplements in hypertension.
Dietary intakes of potassium , calcium , and magnesium have each been reported to lower blood pressure , but the extent of blood pressure reduction in epidemiological studies and clinical trials has tended to be small and inconsistent . We hypothesized that combinations of these mineral supplements would lower blood pressure and that the reductions would be greater than that usually reported in studies of each cation alone . One hundred twenty-five patients 82 men and 43 women ) with untreated mild or borderline hypertension were r and omly assigned to daily treatment with one of the following four regimens : 60 mmol potassium and 25 mmol ( 1000 mg ) calcium , 60 mmol potassium and 15 mmol ( 360 mg ) magnesium , calcium and magnesium , or placebo .  St and ardized clinic blood pressure measurements were obtained on 3 days at baseline and after 3 and 6 months of treatment . At baseline , systolic and diastolic blood pressures ( mean + /- SD ) were 139 + /- 12 and 90 + /- 4 mm Hg , respectively , and dietary intakes of potassium , calcium , and magnesium were 77 + /- 32 , 19 + /- 13 , and 12 + /- 52 mmol/d , respectively . The mean differences ( with 95 % confidence intervals ) of the changes in systolic and diastolic blood pressures between the treatment and placebo groups were not significant : -0.7 ( -4.3 to + 2.9 ) and -0.4 ( -2.9 to + 2.1 ) for potassium and calcium , -1.3 ( -4.4 to + 1.8 ) and 0.4 ( -2.5 to + 3.3 ) for potassium and magnesium , and + 2.1 ( -1.8 to + 6.0 ) and + 2.2 ( -1.0 to + 5.4 ) for calcium and magnesium . In conclusion , this trial provides little evidence of an important role of combinations of cation supplements in the treatment of mild or borderline hypertension
Robust statistically significant effects were found for improved diet , aerobic exercise , alcohol and sodium restriction , and fish oil supplements : mean reductions in systolic blood pressure of 5.0 mmHg [ 95 % confidence interval ( CI ) : 3.1 - 7.0 ] , 4.6 mmHg ( 95 % CI : 2.0 - 7.1 ) , 3.8 mmHg ( 95 % CI : 1.4 - 6.1 ) , 3.6 mmHg ( 95 % CI : 2.5 - 4.6 ) and 2.3 mmHg ( 95 % CI : 0.2 - 4.3 ) , respectively , with corresponding reductions in diastolic blood pressure .
Relaxation significantly reduced blood pressure only when compared with non-intervention controls .
We found no robust evidence of any important effect on blood pressure of potassium , magnesium or calcium supplements .
Available evidence does not support relaxation therapies , calcium , magnesium or potassium supplements to reduce blood pressure
PURPOSE To quantify effectiveness of lifestyle interventions for hypertension .