Within spinal pain , patients with neck pain were found to have the highest prevalence rates of MTrPs .
The trapezius descendens , levator scapulae , and suboccipitales muscles were the most prevalent locations for active MTrPs in patients with neck pain .
Latent MTrPs were present in asymptomatic people , but no significant differences were found in the prevalence rate of latent MTrPs between patients with spinal ( neck ) pain and healthy controls .
The only study investigating prevalence of MTrPs in different localizations of the same muscle reported no significant differences in prevalence between active and latent MTrPs within the trapezius descendens muscle .
Studies examining pathophysiological mechanisms underlying MTrPs demonstrated an acidic environment , high concentration of algogenic/inflammatory substances , stiffer muscle tissue , retro grade diastolic blood flows , spontaneous muscle activity at rest , and loss of muscle contractibility in muscles with MTrPs .
Altered central processing was also found to play a role in the development of MTrPs .
Myofascial trigger points are a prevalent clinical entity , especially in patients with neck pain .
Evidence was not found to support or deny the role of MTrPs in other spinal pain .
Compelling evidence supports local mechanisms underlying MTrPs .
OBJECTIVE A systematic review was performed to evaluate the existing evidence related to the prevalence , incidence , localization , and pathophysiology of myofascial trigger points ( MTrPs ) in patients with spinal ( back and neck ) pain .
An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle.
Myofascial pain associated with myofascial trigger points ( MTrPs ) is a common cause of nonarticular musculoskeletal pain . Although the presence of MTrPs can be determined by soft tissue palpation , little is known about the mechanisms and biochemical milieu associated with persistent muscle pain . A microanalytical system was developed to measure the in vivo biochemical milieu of muscle in near real time at the subnanogram level of concentration . The system includes a microdialysis needle capable of continuously collecting extremely small sample s ( approximately 0.5 microl ) of physiological saline after exposure to the internal tissue milieu across a 105-microm-thick semi-permeable membrane . This membrane is positioned 200 microm from the tip of the needle and permits solutes of < 75 kDa to diffuse across it . Three subjects were selected from each of three groups ( total 9 subjects ) : normal ( no neck pain , no MTrP ) ; latent ( no neck pain , MTrP present ) ; active ( neck pain , MTrP present ) . The microdialysis needle was inserted in a st and ardized location in the upper trapezius muscle . Due to the extremely small sample size collected by the microdialysis system , an established microanalytical laboratory , employing immunoaffinity capillary electrophoresis and capillary electrochromatography , performed analysis of selected analytes . Concentrations of protons , bradykinin , calcitonin gene-related peptide , substance P , tumor necrosis factor-alpha , interleukin-1beta , serotonin , and norepinephrine were found to be significantly higher in the active group than either of the other two groups ( P < 0.01 ) . pH was significantly lower in the active group than the other two groups ( P < 0.03 ) . In conclusion , the described microanalytical technique enables continuous sampling of extremely small quantities of substances directly from soft tissue , with minimal system perturbation and without harmful effects on subjects . The measured levels of analytes can be used to distinguish clinical ly distinct groups
Within spinal pain , patients with neck pain were found to have the highest prevalence rates of MTrPs .
The trapezius descendens , levator scapulae , and suboccipitales muscles were the most prevalent locations for active MTrPs in patients with neck pain .
Latent MTrPs were present in asymptomatic people , but no significant differences were found in the prevalence rate of latent MTrPs between patients with spinal ( neck ) pain and healthy controls .
The only study investigating prevalence of MTrPs in different localizations of the same muscle reported no significant differences in prevalence between active and latent MTrPs within the trapezius descendens muscle .
Studies examining pathophysiological mechanisms underlying MTrPs demonstrated an acidic environment , high concentration of algogenic/inflammatory substances , stiffer muscle tissue , retro grade diastolic blood flows , spontaneous muscle activity at rest , and loss of muscle contractibility in muscles with MTrPs .
Altered central processing was also found to play a role in the development of MTrPs .
Myofascial trigger points are a prevalent clinical entity , especially in patients with neck pain .
Evidence was not found to support or deny the role of MTrPs in other spinal pain .
Compelling evidence supports local mechanisms underlying MTrPs .
OBJECTIVE A systematic review was performed to evaluate the existing evidence related to the prevalence , incidence , localization , and pathophysiology of myofascial trigger points ( MTrPs ) in patients with spinal ( back and neck ) pain .