Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
The effects of a low-carbohydrate versus low-fat diet on adipocytokines in severely obese adults: three-year follow-up of a randomized trial.
BACKGROUND Adipocytokines are associated with insulin resistance and cardiovascular disease and can be modified with weight loss . While we previously demonstrated weight loss and a reduction in leptin in obese adults who followed a low-carbohydrate diet for 6 months , the long-term effects of this diet on adipocytokines are unknown . METHODS 132 obese adults with a body mass index of > or = 35 kg/m2 were r and omized to receive one year of dietary counseling to follow either a low-carbohydrate diet < 30 g/day ( LC ) or a caloric-restricted diet ( reduced by 500 calories/day with < 30 % of calories from fat ) ( LF ) . Weight , leptin , adiponectin , TNF-alpha , CRP , and insulin were measured at 0 , 6 , and 36 months ( 24 months post-counseling ) . Follow-up data at was collected for 53 participants who returned at 36 months . RESULTS Mean weight change from baseline was not different between the groups at 36 months . Between 6 and 36 months weight was unchanged for LF , while LC appeared to regain weight [ + 4.84 + /- 35.6 kg ( + 3.0 % ) ] . This difference , however , was not significant ( p = 0.08 ) . Leptin was unchanged in LF at both 6 and 36 months . In LC leptin decreased by 8.49 + /- 6.4 ng/mL or 22.7 % at 6 months ( p < 0.001 ) and increased by 10.68 + /- 25.2 ng/mL or 41.9 % between 6 and 36 months ( p = 0.02 ) . There were no differences in insulin , adiponectin , TNF-alpha , or CRP between the groups . CONCLUSIONS Favorable changes in leptin that accompany weight loss are not sustained in individuals who followed a low-carbohydrate diet for one year . A low-carbohydrate diet had no significant effect on insulin , adiponectin , TNF-alpha , or CRP compared to a low-fat diet at 36 months
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .