There was a suggestion that whole-body or lumbar spine BMD may be a useful biomarker in older people but not in adolescents .
This systematic review confirmed that circulating 25(OH)D is a robust and reliable marker of vitamin D status .
BACKGROUND Although serum 25-hydroxyvitamin D [ 25(OH)D ] is the currently accepted vitamin D status marker of choice , use of other biomarkers or functional endpoints have been suggested .
OBJECTIVE The objective was to systematic ally review the effectiveness of 25(OH)D , parathyroid hormone ( PTH ) , bone turnover markers , bone mineral density ( BMD ) , and calcium absorption as biomarkers of vitamin D status .
Bone mineral content and serum 25-hydroxyvitamin D concentration in breast-fed infants with and without supplemental vitamin D.
Eighteen term , healthy , appropriate for gestational age , breast-fed infants were studied in a double-blind prospect i ve study to determine whether or not supplemental vitamin D affected bone mineralization .  All patients were from a single , private pediatric practice . Nine infants were r and omly assigned to a vitamin D supplement of 400 IU/day and nine infants to a placebo . By 12 weeks of age , infants receiving placebo had a significant decrease in bone mineralization and in serum 25-hydroxyvitamin D concentrations compared to the vitamin D-supplemented group . It is not known whether or not the increased BMC at 12 weeks of age in vitamin D-supplemented breast-fed infants is of ultimate value . Supplemental vitamin D may be necessary for optimal bone mineralization in term breast-fed infants . A longer follow-up study and additional analyses are required to make conclusive statements
There was a suggestion that whole-body or lumbar spine BMD may be a useful biomarker in older people but not in adolescents .
This systematic review confirmed that circulating 25(OH)D is a robust and reliable marker of vitamin D status .
BACKGROUND Although serum 25-hydroxyvitamin D [ 25(OH)D ] is the currently accepted vitamin D status marker of choice , use of other biomarkers or functional endpoints have been suggested .
OBJECTIVE The objective was to systematic ally review the effectiveness of 25(OH)D , parathyroid hormone ( PTH ) , bone turnover markers , bone mineral density ( BMD ) , and calcium absorption as biomarkers of vitamin D status .