Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention .
The data are insufficient to recommend the use of statins before EC .
Finally , perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF
The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation ( AF ) , inflammation and oxidative stress , with emphasis on the potential of statins to decrease the incidence of different types of AF , including new-onset AF , after electrical cardioversion ( EC ) and after cardiac surgery .
Observational and clinical trials have studied the impact of statin therapy on new-onset , post-EC or postoperative AF .
Usefulness of Serum Carboxy-Terminal Propeptide of Procollagen Type I in Assessment of the Cardioreparative Ability of Antihypertensive Treatment in Hypertensive Patients
Background —We investigated whether serum concentration of carboxy-terminal propeptide of procollagen type I ( PIP ) , a marker of collagen type I synthesis , can be used to assess the ability of antihypertensive treatment to regress myocardial fibrosis in hypertensive patients . Methods and Results —The study was performed in 37 patients with essential hypertension and hypertensive heart disease . After r and omization , 21 patients were assigned to losartan and 16 patients to amlodipine treatment . At baseline and after 12 months , right septal endomyocardial biopsies were performed to quantify collagen volume fraction ( CVF ) on picrosirius red – stained sections with an automated image- analysis system . Serum PIP was measured by specific radioimmunoassay . Nineteen patients in the losartan group and 11 in the amlodipine group finished the study . Time-course changes in blood pressure during treatment were similar in the 2 groups of patients . In losartan-treated patients , CVF decreased from 5.65±2.03 % to 3.96±1.46 % ( P < 0.01 ) and PIP from 127±30 to 99±26 & mgr;g/L ( P < 0.01 ) . Neither CVF or PIP changed significantly in amlodipine-treated patients . CVF was directly correlated with PIP ( r = 0.44 , P < 0.001 ) in all hypertensives before and after treatment . Conclusions —These findings suggest that the ability of antihypertensive treatment to regress fibrosis in hypertensives with biopsy-proven myocardial fibrosis is independent of its antihypertensive efficacy . Our data also suggest that blockade of the angiotensin II type 1 receptor is associated with inhibition of collagen type I synthesis and regression of myocardial fibrosis in hypertensives . Thus , determination of serum PIP may be useful to assess the cardioreparative properties of antihypertensive treatment in hypertensives
Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention .
The data are insufficient to recommend the use of statins before EC .
Finally , perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF
The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation ( AF ) , inflammation and oxidative stress , with emphasis on the potential of statins to decrease the incidence of different types of AF , including new-onset AF , after electrical cardioversion ( EC ) and after cardiac surgery .
Observational and clinical trials have studied the impact of statin therapy on new-onset , post-EC or postoperative AF .