No alteration in plasma IL-6 concentration was observed .
Pentoxifylline did not alter BP or plasma IL-6 concentration , but significantly reduced circulating TNF-α and CRP concentrations
INTRODUCTION Pentoxifylline is a xanthine derivative with potential cardiovascular benefits .
AIM To evaluate the impact of pentoxifylline on  blood pressure ( BP )  and plasma TNF-α , C-reactive protein ( CRP ) and IL-6 through a systematic review and meta- analysis of r and omized controlled trials .
Effect of Pentoxifylline on inflammatory burden, oxidative stress and platelet aggregability in hypertensive type 2 diabetes mellitus patients.
OBJECTIVES Inflammation and oxidative stress are main culprits behind atherosclerosis in diabetes mellitus . This study explores the effect of add-on Pentoxifylline on inflammatory burden and oxidative stress in hypertensive diabetic patients . RESEARCH DESIGN AND METHODS 60 hypertensive type 2 diabetic , aged > or = 45 years were evaluated for anthropometry , clinical parameters , C-reactive protein , total leukocyte count , erythrocyte sedimentation rate , serum albumin , plasma malondialdehyde , blood reduced glutathione , platelet aggregation and clot retraction profile . With informed consent and r and omization , Pentoxifylline ( 400 mg ) was prescribed to 30 patients orally twice daily with meals as add-on therapy to the st and ard therapeutic regimen for one month . The particular parameters were repeated in 26 patients in control group and 25 patients in Pentoxifylline group who completed the follow up . The study was a r and omized , open , add-on clinical trial with parallel controls . RESULTS At one-month follow-up , in the Pentoxifylline group , there was 20.9 % decrease ( p<0.001 ) in C-reactive protein , 18 % reduction ( p<0.001 ) in erythrocyte sedimentation rate , 11.1 % reduction ( p<0.001 ) in total leukocyte count and 5.8 % increase ( p=0.003 ) in serum albumin .  Pentoxifylline showed 20.2 % reduction in plasma malondialdehyde and 4.6 % increase in blood reduced glutathione level . In therapeutic dose range , Pentoxifylline exerted a significant anti-aggregatory effect and a dose dependent decrease in clot retraction in-vitro but there was no significant change in ex-vivo clot retraction . The control group showed no statistically significant change in parameters assessed . CONCLUSION This study reveals improvements in inflammatory markers , oxidative stress and platelet-aggregation by Pentoxifylline , thus preventing atherosclerosis in diabetes mellitus
No alteration in plasma IL-6 concentration was observed .
Pentoxifylline did not alter BP or plasma IL-6 concentration , but significantly reduced circulating TNF-α and CRP concentrations
INTRODUCTION Pentoxifylline is a xanthine derivative with potential cardiovascular benefits .
AIM To evaluate the impact of pentoxifylline on  blood pressure ( BP )  and plasma TNF-α , C-reactive protein ( CRP ) and IL-6 through a systematic review and meta- analysis of r and omized controlled trials .