Sensitivity analyses and meta-regression for hemoglobin suggested a higher response with lower trial quality ( suboptimal allocation concealment and blinding ) , use of condiments , and sodium iron edetate and a lower response when adults were included .
Consumption of iron-fortified foods results in an improvement in hemoglobin , serum ferritin , and iron nutriture and a reduced risk of remaining anemic and iron deficient
BACKGROUND The utility of iron fortification of food to improve iron deficiency , anemia , and biological outcomes is not proven unequivocally .
A randomized trial of two levels of iron supplementation and developmental outcome in low birth weight infants.
OBJECTIVES To investigate the effect of increased iron intakes on hematologic status and cognition in low birth weight infants . STUDY DESIGN We r and omly assigned 58 infants to receive formula with 13.4 mg iron/L ( normal iron ) or 20.7 mg iron/L ( high iron ) . At baseline , discharge , and at 3 , 6 , 9 , and 12 months ' corrected age , we assessed anthropometry ; infections ; red blood cell hemoglobin , catalase , glutathione peroxidase , red blood cell fragility ( hydrogen peroxide test ) , and superoxide dismutase values ; plasma malondialdehyde , ferritin , iron , transferrin , zinc and copper levels ; and  diet intake . Griffiths ' Development Assessment was done at 3 , 6 , 9 , and 12 months only . RESULTS No statistical differences ( P < .05 ) were noted for weight , catalase or malondialdehyde levels , red blood cell fragility , or Griffith 's Development Assessment . Iron intakes were greater in the high iron group except at 12 months . Hemoglobin ( high iron , 123 + /- 9 ; normal iron , 118 + /- 8) was not different at 3 months ( P = .07 ) . Plasma zinc levels ( high iron , 70 + /- 14 ; normal iron , 89 + /- 27 ) and copper levels ( high iron , 115 + /- 26 ; normal iron , 132 + /- 27 ; P = .06 ) at 12 months suggested inhibition of absorption by high iron formula . Glutathione peroxidase levels were higher in the high iron group . The total number of respiratory tract infections was greater in the high iron group ( 3.3 + /- 0.9 ) than in the normal iron group ( 2.5 + /- 0.9 ) . CONCLUSION In terms of cognitive outcome , there is no advantage associated with elevated iron intake for low birth weight infants
Sensitivity analyses and meta-regression for hemoglobin suggested a higher response with lower trial quality ( suboptimal allocation concealment and blinding ) , use of condiments , and sodium iron edetate and a lower response when adults were included .
Consumption of iron-fortified foods results in an improvement in hemoglobin , serum ferritin , and iron nutriture and a reduced risk of remaining anemic and iron deficient
BACKGROUND The utility of iron fortification of food to improve iron deficiency , anemia , and biological outcomes is not proven unequivocally .