Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Rapid effect of pravastatin on endothelial function and lipid peroxidation in unstable angina.
BACKGROUND Oxidative stress contributes to endothelial dysfunction , an important step to the pathogenesis of atherosclerosis and coronary events . Latest studies revealed the existence of pleiotropic and especially antioxidant properties of statins . We sought to examine the effects of pravastatin on lipid peroxidation and endothelial function , independently from lipid-lowering , in patients with unstable angina ( UA ) . METHODS Thirty-seven patients ( males ) , 64.46+/-9.09 years , suffering from UA enrolled in the study . Patients were not on statin medication before admission and they received after r and omization either 40 mg pravastatin daily ( group A , n = 20 ) , or placebo ( group B , n = 17 ) . Malondialdehyde ( MDA ) concentration , an index of lipid peroxidation and plaque instability , flow-mediated dilatation ( FMD ) of the brachial artery and blood lipids were measured on the second day of hospitalization and 10 days later . RESULTS MDA decreased significantly in both groups ( A , p = 0.008 ; B , p = 0.003 ) . FMD increased significantly in group A ( p = 0.007 ) , whereas in group B it did not change . Serum lipids remained unaltered in all three groups . CONCLUSIONS Pravastatin administration improved FMD within 10 days and this favorable effect occurred before any significant reduction in blood lipids , revealing its pleiotropic effects during the early phase of an acute coronary syndrome . Circulating lipid peroxidation products in patients with UA decreased significantly during the same period independently of endothelial function and pravastatin therapy
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .