Using the Cochrane methodology , and as measures of effect size mean difference and Hedge 's g , SRIs proved to be superior to drug placebo , with a modest effect size .
From direct comparisons of CBT and SRI treatments , we conclude that CBT has the superior efficacy .
COMBO versus CBT shows that SRI treatment adds little to concomitant CBT , while COMBO shows favourable outcome versus SRI alone .
In pre-trial partial treatment responders , those who failed a SRI had better outcome from adding CBT as compared to continuing a SRI .
Those who failed CBT treatment did as well with continued CBT as with switching to a SRI .
Serotonin reuptake inhibiting drugs ( SRI ) have been used in the treatment of paediatric obsessive-compulsive disorder over the past 30 years .
The effect of fluvoxamine and behavior therapy on children and adolescents with obsessive-compulsive disorder.
OBJECTIVE The efficacy of medications , consisting of serotonin partial and specific reuptake blockers , and behavior therapy , consisting of exposure and response prevention in addition to social skills training , cognitive therapy , and habit reversal , in the treatment of obsessive-compulsive disorder are well documented . The purpose of the study was to explore if adding behavior therapy to medication would enhance treatment efficacy . METHODS Ten children/adolescents who had not previously responded to behavior therapy  were r and omly assigned to two groups : fluvoxamine alone or fluvoxamine with behavior therapy . All 10 patients received fluvoxamine for 10 weeks-five continued solely on fluvoxamine for one year and five engaged in behavior therapy for 20 sessions along with fluvoxamine and then continued solely on medication until the end of the year . RESULTS Eight of 10 patients improved significantly on fluvoxamine at week 10 on the primary outcome variable , the Children 's Yale-Brown Obsessive Compulsive Scale ( CY-BOCS ) . According to the other measurements -National Institute of Mental Health-Global Obses-sive-Compulsive Scale , Clinical Global Impression-Improvement ( assessing level of im-provement from week to week ) , and Clinical Global Impression-Severity of Illness Scale ( as-sessing how ill the patient is from week to week)-improvement was not as evident . According to the CY-BOCS , those who received a combination of fluvoxamine and exposure with response prevention showed significantly more improvement than those who only took medication . At two-year follow-up , all patients continued to improve , with those in the combined approach improving more than those in the medication-alone group . CONCLUSIONS Future studies should determine the specific effect of each treatment group , combined and singularly . Reasons for discrepancy in improvement ratings as noted by the different instruments are discussed . The addition of behavior therapy to fluvoxamine seems to enhance treatment efficacy , according to the CY-BOCS
Using the Cochrane methodology , and as measures of effect size mean difference and Hedge 's g , SRIs proved to be superior to drug placebo , with a modest effect size .
From direct comparisons of CBT and SRI treatments , we conclude that CBT has the superior efficacy .
COMBO versus CBT shows that SRI treatment adds little to concomitant CBT , while COMBO shows favourable outcome versus SRI alone .
In pre-trial partial treatment responders , those who failed a SRI had better outcome from adding CBT as compared to continuing a SRI .
Those who failed CBT treatment did as well with continued CBT as with switching to a SRI .
Serotonin reuptake inhibiting drugs ( SRI ) have been used in the treatment of paediatric obsessive-compulsive disorder over the past 30 years .