In the third-line setting , for patients who have not received erlotinib or gefitinib , treatment with erlotinib is recommended .
There are insufficient data to recommend routine third-line cytotoxic therapy .
Purpose To provide evidence -based recommendations to up date the American Society of Clinical Oncology guideline on systemic therapy for stage IV non – small-cell lung cancer ( NSCLC ) .
Results This guideline up date reflects changes in evidence since the previous guideline .
Liposomal cisplatin combined with paclitaxel versus cisplatin and paclitaxel in non-small-cell lung cancer: a randomized phase III multicenter trial
Background : Liposomal cisplatin is a new formulation developed to reduce the systemic toxicity of cisplatin while simultaneously improving the targeting of the drug to the primary tumor and to metastases by increasing circulation time in the body fluids and tissues . The primary objectives were to determine nephrotoxicity , gastrointestinal side-effects , peripheral neuropathy and hematological toxicity and secondary objectives were to determine the response rate , time to tumor progression ( TTP ) and survival . Patients and methods : Two hundred and thirty-six chemotherapy-naive patients with inoperable non-small-cell lung cancer were r and omly allocated to receive either 200 mg/m2 of liposomal cisplatin and 135 mg/m2 paclitaxel ( arm A ) or 75 mg/m2 cisplatin and 135 mg/m2 paclitaxel ( arm B ) , once every 2 weeks on an outpatient basis . Two hundred and twenty-nine patients were assessable for toxicity , response rate and survival . Nine treatment cycles were planned . Results : Arm A patients showed statistically significant lower nephrotoxicity , grade 3 and 4 leucopenia , grade 2 and 3 neuropathy , nausea , vomiting and fatigue . There was no significant difference in median and overall survival and TTP between the two arms ; median survival was 9 and 10 months in arms A and B , respectively , and TTP was 6.5 and 6 months in arms A and B , respectively . Conclusions : Liposomal cisplatin in combination with paclitaxel has been shown to be much less toxic than the original cisplatin combined with paclitaxel .  Nephrotoxicity in particular was negligible after liposomal cisplatin administration . TTP and survival were similar in both treatment arms
In the third-line setting , for patients who have not received erlotinib or gefitinib , treatment with erlotinib is recommended .
There are insufficient data to recommend routine third-line cytotoxic therapy .
Purpose To provide evidence -based recommendations to up date the American Society of Clinical Oncology guideline on systemic therapy for stage IV non – small-cell lung cancer ( NSCLC ) .
Results This guideline up date reflects changes in evidence since the previous guideline .