R and omized controlled trials found a positive correlation for SB with BMI , neck circumference , fat mass , HbA1C , cholesterol and insulin levels , cohort studies additionally for WC , leptin , C-peptide , ApoA1 and Low density lipoprotein and a negative correlation for HDL .
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin .
OBJECTIVE Pathomechanisms of sedentary behaviour ( SB ) are unclear .
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults .
Motivational counseling to reduce sitting time: a community-based randomized controlled trial in adults.
BACKGROUND Sedentary behavior is regarded as a distinct risk factor for cardiometabolic morbidity and mortality , but knowledge of the efficacy of interventions targeting reductions in sedentary behavior is limited . PURPOSE To investigate the effect of an individualized face-to-face motivational counseling intervention aim ed at reducing sitting time . DESIGN A r and omized , controlled , observer-blinded , community-based trial with two parallel groups using open-end r and omization with 1:1 allocation . SETTING / PARTICIPANTS A total of 166 sedentary adults were consecutively recruited from the population -based Health2010 Study . INTERVENTION Participants were r and omized to a control ( usual lifestyle ) or intervention group with four individual theory-based counseling sessions . MAIN OUTCOME MEASURES Objective ly measured overall sitting time ( ActivPAL 3TM , 7 days ) ; secondary measures were breaks in sitting time , anthropometric measures , and cardiometabolic biomarkers , assessed at baseline and after 6 months . Data were collected in 2010 - 2012 and analyzed in 2013 - 2014 using repeated measures multiple regression analyses . RESULTS Ninety-three participants were r and omized to the intervention group and 73 to the control group , and 149 completed the study . The intervention group had a mean sitting time decrease of -0.27 hours/day , corresponding to 2.9 % of baseline sitting time ( hours/day ) ; the control group increased mean sitting time by 0.06 hours/day . The between-group difference in change , -0.32 hours/day ( 95 % CI=-0.87 , 0.24 , p=0.26 ) , was not statistically significant . Significant differences in change in fasting serum insulin of -5.9 pmol/L ( 95 % CI=-11.4 , -0.5 , p=0.03 ) ; homeostasis model assessment -estimated insulin resistance of -0.28 ( 95 % CI=-0.53 , -0.03 , p=0.03 ) ; and waist circumference of -1.42 cm ( 95 % CI=-2.54 , -0.29 , p=0.01 ) were observed in favor of the intervention group . CONCLUSIONS Although the observed decrease in sitting time was not significant , a community-based , individually tailored , theory-based intervention program aim ed at reducing sitting time may be effective for increasing st and ing and improving cardiometabolic health in sedentary adults . TRIAL REGISTRATION This study is registered at Clinical trials.gov ( NCT00289237 )
R and omized controlled trials found a positive correlation for SB with BMI , neck circumference , fat mass , HbA1C , cholesterol and insulin levels , cohort studies additionally for WC , leptin , C-peptide , ApoA1 and Low density lipoprotein and a negative correlation for HDL .
Most studied biomarkers associated with SB were of cardiovascular or metabolic origin .
OBJECTIVE Pathomechanisms of sedentary behaviour ( SB ) are unclear .
We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults .