We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .
Effects of fish oil on VLDL triglyceride kinetics in humans.
Dietary n-3 fatty acids ( FAs ) found in fish oils markedly lower plasma triglyceride ( TG ) and very low density lipoprotein ( VLDL ) levels in both normal and hypertriglyceridemic subjects . The present study examined the mechanism of this effect . Ten subjects with widely different plasma triglyceride levels ( 82 to 1002 mg/dl ) were fed metabolically controlled diets containing 20 % fat . The control diet contained a blend of cocoa butter and peanut oil ( P/S = 0.8 ) . The test diet contained fish oil ( P/S = 1.1 ) and provided 10 - 17 g of n-3 FAs per day ( depending on calorie intake ) . After 3 to 5 weeks of each diet , the kinetics of VLDL-TG were determined over a 48-h period after the injection of [3H]glycerol . The fish oil diet reduced the VLDL-TG synthetic rate from 23 + /- 14.3 ( mean + /- SD ) to 12.6 + /- 7.5 mg/h per kg ideal weight ( P less than 0.005 ) and increased the fractional catabolic rate ( FCR ) for VLDL-TG from 0.23 + /- 0.12 to 0.38 + /- 0.16 h -1 ( P less than 0.005 ) . At the same time , there was a 66 % reduction of plasma triglyceride levels , result ing largely from a 78 % decrease in VLDL-TG levels ( 398 + /- 317 to 87 + /- 77 mg/dl ; P less than 0.005 ) . There was a strong correlation ( r = 0.83 ; P less than 0.01 ) between the change in synthetic rates and pool sizes , but there was no correlation ( r = 0.24 ; NS ) between changes in FCRs and pool sizes . The VLDL cholesterol : triglyceride ratio increased during the n-3 diet suggesting that smaller VLDL particles were present . These particles would be expected to leave the VLDL fraction more rapidly than larger particles producing a higher FCR . We conclude that the hypotriglyceridemic effect of fish oil appears to be caused primarily by an inhibition of very low density lipoprotein-triglyceride synthesis , but an additional , independent effect upon VLDL catabolism can not be ruled out
We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .