CONCLUSIONS The effects of treatment with clomipramine and selective serotonin reuptake inhibitors ( SSRIs : fluvoxamine , sertraline , fluoxetine , citalopram , and escitalopram ) proved to be similar , except for the lower adherence rate in case of clomipramine because of its side effects .
PURPOSE This systematic review examines the efficacy of pharmacological therapy for obsessive-compulsive disorder ( OCD ) , addressing two major issues : which treatment is most effective in treating the patient 's symptoms and which is beneficial for maintaining remission .
A double-blind combination study of clonazepam with sertraline in obsessive-compulsive disorder.
This double blind , r and omized , parallel , placebo-controlled study investigates whether clonazepam accelerates and / or increases the overall response in patients with obsessive compulsive disorder ( OCD ) who are treated with sertraline . Thirty-seven patients were r and omized with 20 in the sertraline and clonazepam group and 17 in the sertraline and placebo groups . Male and female out patients , age 18 - 65 years , met criteria for a primary diagnosis of obsessive compulsive disorder according to DSM-IV , as determined by the structured clinical MINI interview . Appropriate safety and efficacy parameters were measured throughout the study . The determination of efficacy was based primarily on changes from baseline to the last observation taken through week 12 . Analysis revealed no significant difference between groups at endpoint on the main scale
CONCLUSIONS The effects of treatment with clomipramine and selective serotonin reuptake inhibitors ( SSRIs : fluvoxamine , sertraline , fluoxetine , citalopram , and escitalopram ) proved to be similar , except for the lower adherence rate in case of clomipramine because of its side effects .
PURPOSE This systematic review examines the efficacy of pharmacological therapy for obsessive-compulsive disorder ( OCD ) , addressing two major issues : which treatment is most effective in treating the patient 's symptoms and which is beneficial for maintaining remission .