In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .
Dual association between polyphenol intake and breast cancer risk according to alcohol consumption level: a prospective cohort study
Studies of the association between polyphenols dietary intake and  breast cancer risk have been limited due to the lack of detailed food composition tables . In addition , none has examined this association according to alcohol intake , despite the facts that alcohol is an established risk factor for breast cancer and that the contribution of alcoholic beverages to polyphenol intake varies according to the level of alcohol consumption . Our objectives were ( 1 ) to estimate the associations between breast cancer risk and a wide range of dietary polyphenols using the recently published Phenol-Explorer data base ; and ( 2 ) to evaluate if/how alcohol intake modulates these relationships . 4,141 women from the SU.VI.MAX prospect i ve cohort were followed from 1994 to 2007 ( median followup : 12.6 years ) ; 152 developed a first incident invasive primary breast cancer .  Dietary intakes  were assessed by repeated 24-h records . The Phenol-Explorer data base was used to estimate polyphenol intake . Multivariable Cox proportional hazards models were used to calculate hazard ratios ( HRs ) and 95 % confidence intervals ( CIs ) for quartiles of polyphenol intake . Analyses were stratified by median alcohol intake ( < vs. ≥6.5 g/d ) . In non-to-low alcohol drinkers , intakes of some classes of polyphenols were associated with decreased breast cancer risk : hydroxybenzoic acids ( HRQ4vsQ1 = 0.38 , 95 % CI : 0.17–0.86 , Ptrend = 0.005 ) , flavonoids ( 0.35 , 0.17–0.75 , Ptrend = 0.02 ) , flavonols ( 0.36 , 0.18–0.74 , Ptrend = 0.002 ) , catechins ( 0.48 , 0.22–1.05 , Ptrend = 0.02 ) , theaflavins ( 0.42 , 0.19–0.93 , Ptrend = 0.02 ) , and proanthocyanidins ( 0.39 , 0.18–0.84 , Ptrend = 0.02 ) . In contrast , in women with higher alcohol use  , intakes of hydroxybenzoic acids ( 2.28 , 1.16–4.49 , Ptrend = 0.04 ) , flavonoids ( 2.46 , 1.23–4.92 , Ptrend = 0.01 ) , anthocyanins ( 2.94 , 1.32–6.53 , Ptrend = 0.01 ) , catechins ( 2.28 , 1.19–4.36 , Ptrend = 0.02 ) , and proanthocyanidins ( 2.98 , 1.40–6.33 , Ptrend = 0.006 ) were associated with increased breast cancer risk . In conclusion , this prospect i ve study suggests that several classes of polyphenols could potentially contribute to breast cancer prevention among non-to-low alcohol drinkers , but some may increase breast cancer risk among women with higher alcohol intake
In conclusion , polyphenols can successfully reduce HbA1c in T2DM without any intervention at glycemia , and could contribute to the prevention of diabetes complications
ABSTRACT Polyphenols have been extensively studied for their antioxidant and anti-inflammatory properties .
Recently , their antiglycative actions by oxidative stress modulation have been linked to the prevention of diabetes and associated complications .
This article assesses the evidence for polyphenol interventions on glycohemoglobin ( HbA1c ) in non-diabetic , pre-diabetic , and type 2 diabetes mellitus ( T2DM ) subjects .