AUTHORS ' CONCLUSIONS Feeding with a soy formula can not be recommended for prevention of allergy or food intolerance in infants at high risk of allergy or food intolerance .
BACKGROUND Allergies and food reactions in infants and children are common and may be associated with a variety of foods including adapted cow 's milk formula .
Soy based formulas have been used to treat infants with allergy or food intolerance .
However , it is unclear whether they can help prevent allergy and food intolerance in infants without clinical evidence of allergy or food intolerance .
OBJECTIVES To determine the effect of feeding adapted soy formula compared to human milk , cow 's milk formula or a hydrolysed protein formula on preventing allergy or food intolerance in infants without clinical evidence of allergy or food intolerance .
Prospective oral food challenge study of two soybean protein isolates in patients with possible milk or soy protein enterocolitis.
The soybean protein isolate used in powdered soybean formula is hydrolyzed more extensively than the isolate which is used in liquid soybean formula in most commercial soybean formulas . Previous in vitro studies have shown differences in human antibody response to these soybean protein isolates . Therefore , a prospect i ve clinical study was undertaken to determine if there were differences in adverse reaction rates to these soybean protein isolates . Forty-three patients with possible milk- and /or soy-protein enterocolitis were enrolled in this study . Patients had 3 separate oral food challenges ; using milk formula , soybean powder formula and soybean liquid formula . Ten ( 23 % ) patients challenged with milk had positive challenges . Fourteen ( 33 % ) patients challenged with powdered soy formula had positive challenges while thirteen ( 30 % ) challenged with liquid soy formula had positive challenges . In the 10 patients with positive milk challenges , 6 ( 60 % ) had a positive soy challenge . In the group with positive soy challenges , 5 reacted to the  powdered soy  challenge done first , but not the second challenge with the liquid soy formula , and 4 patients reacted to the liquid soy formula challenge done first , but not the second challenge with the powdered soy formula . These results indicate that a significant number of patients with milk protein enterocolitis have soy protein enterocolitis . In addition , an order effect can be demonstrated in the soy challenges because of the tendency to react to the first soy challenge regardless of the type of isolate . These results suggest that a local immune effect caused by the protein may be present
AUTHORS ' CONCLUSIONS Feeding with a soy formula can not be recommended for prevention of allergy or food intolerance in infants at high risk of allergy or food intolerance .
BACKGROUND Allergies and food reactions in infants and children are common and may be associated with a variety of foods including adapted cow 's milk formula .
Soy based formulas have been used to treat infants with allergy or food intolerance .
However , it is unclear whether they can help prevent allergy and food intolerance in infants without clinical evidence of allergy or food intolerance .
OBJECTIVES To determine the effect of feeding adapted soy formula compared to human milk , cow 's milk formula or a hydrolysed protein formula on preventing allergy or food intolerance in infants without clinical evidence of allergy or food intolerance .