Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .
Nicardipine vs. saline injection as treatment for Peyronie's disease: a prospective, randomized, single-blind trial.
INTRODUCTION Various conservative treatments for Peyronie 's disease ( PD ) have been attempted over the years . Intralesional verapamil injection has been tested in prospect i ve r and omized studies , but the effect of this treatment seems insufficient . Nicardipine is a calcium antagonist alternative to verapamil and is reportedly more effective in vitro . AIM The objective of our study was to evaluate the usefulness of intralesional nicardipine injection as a conservative treatment for PD in the transition period of acute and chronic phase . METHODS Eighty-six patients ( age : 38 - 72 years , mean : 52 ) were enrolled in this study . A total of 74 patients were assigned r and omly to nicardipine group ( 10 mg diluted in 10 mL of distilled water daily , N=37 ) and control group ( 10 mL of saline water , N=37 ) . A total of six injections were administrated biweekly . MEAN OUTCOME MEASURE The subjects were assessed by International Index of Erectile Function (IIEF)-5 and international pain scale . The plaque size was measured by ultrasonography after 20 µg intracavernosal injection of alprostadil ( prostagl and in E1 ) . The penile curvature was also measured by taking a photograph at maximum rigidity . RESULTS A reduction of pain score was seen throughout the course of treatment in both groups with a significant difference between the nicardipine and control groups ( multiple analysis of variance test , P=0.019 ) . A significant improvement of IIEF-5 score occurred only in the nicardipine group at 48 weeks after the initiation of treatment ( P<0.01 ) . The plaque size was significantly reduced at 48 weeks only in the nicardipine group ( 12 points , P=0.0004 by paired t-test ) . The penile curvature was significantly improved in both groups ( P<0.01 ) without significant difference between them ( P=0.14 ) . There were no severe side effects , such as hypotension or other cardiovascular events . CONCLUSION Our findings indicate that intralesional nicardipine injection is clinical ly effective as a conservative treatment for PD in the transition period of acute and chronic phase
Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .