Prolonged antioxidant vitamin E and /or C supplementation could be effective to improve endothelial function in non-obese T2DM subjects
Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus ( T2DM ) subjects .
The aim of this study was to systematic ally review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects .
Chronic vitamin E administration improves brachial reactivity and increases intracellular magnesium concentration in type II diabetic patients.
Vascular disease accounts for the majority of the clinical complications in diabetes mellitus . As an exaggerated oxidative stress degree has been postulated as the link between diabetes mellitus and endothelial function , a possible positive effect of plasma vitamin E ( Vit . E ) administration on brachial reactivity could be postulated . Our study aims at investigating the possible effect of chronic Vit . E administration on brachial reactivity , oxidative stress indexes , and intracellular magnesium and calcium content in type II diabetic patients free of diabetic complications . Forty adult , type II diabetic patients were enrolled in the study , which was deigned as a double blind , r and omized vs. placebo trial . At baseline all patients underwent the following tests : 1 ) anthropometric and metabolic examinations , 2 ) evaluation of oxidative stress indexes , 3 ) intracellular magnesium and calcium measurements , and 4 ) determination of arterial compliance and distensibility . Then , all patients were r and omly assigned to Vit . E treatment at a dose of 600 mg/day ( Evion Forte ; n = 20 ) or placebo ( n = 20 ) over 8 weeks . At the end of this treatment period , a complete reevaluation of the patients was made . Vit . E treatment was associated with a significant improvement in the percent change in brachial artery diameter ( P<0.03 ) and oxidative stress indexes ( P < 0.005 ) . In the Vit . E group , the percent change in brachial artery diameter correlated positively with the percent change in oxidative stress indexes ( oxidized/reduced glutathione , Trolox-equivalent antioxidant capacity , thiobarbituric acid reaction products , lipid peroxides ) and intracellular cation content ( magnesium and calcium ) . After adjustment for age , sex , body mass index , and wait/hip ratio , all of these correlations remained significant ( P<0.03 for all ) . Furthermore , adjusting for glycosylated hemoglobin , plasma total cholesterol , and homeostatic model index , brachial artery diameter was still correlated with the percent change in oxidative stress indexes ( P<0.04 for all ) . Nevertheless , the relationship between the percent change in brachial artery diameter and oxidative stress indexes was no longer significant after adjustment for intracellular Mg and Ca2 + . In conclusion , our study demonstrates that chronic administration of Vit . E improves brachial artery reactivity in patients with type II diabetes mellitus . Such an effect seems mediated by a reduction in oxidative stress and a regulation of intracellular calcium and magnesium contents
Prolonged antioxidant vitamin E and /or C supplementation could be effective to improve endothelial function in non-obese T2DM subjects
Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus ( T2DM ) subjects .
The aim of this study was to systematic ally review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects .