A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?
Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans.
1 . The present study investigates to what extent and by which time course prolonged strenuous exercise influences the plasma concentration of pro-inflammatory and inflammation responsive cytokines as well as cytokine inhibitors and anti-inflammatory cytokines . 2 . Ten male subjects ( median age 27.5 years , range 24 - 37 ) completed the Copenhagen Marathon 1997 ( median running time 3 : 26 ( h : min ) , range 2 : 40 - 4 : 20 ) . Blood sample s were obtained before , immediately after and then every 30 min in a 4 h post-exercise recovery period . 3 . The plasma concentrations of tumour necrosis factor (TNF)alpha , interleukin (IL)-1beta , IL-6 , IL-1ra , sTNF-r1 , sTNF-r2 and IL-10 were measured by enzyme-linked immunosorbent assay ( ELISA ) . The highest concentration of IL-6 was found immediately after the race , whereas IL-1ra peaked 1 h post exercise ( 128-fold and 39-fold increase , respectively , as compared with the pre-exercise values ) . The plasma level of IL-1beta , TNFalpha , sTNF-r1 and sTNF-r2 peaked in the first hour after the exercise ( 2 . 1- , 2.3- , 2.7- and 1.6-fold , respectively ) . The plasma level of IL-10 showed a 27-fold increase immediately post exercise . 4 . In conclusion , strenuous exercise induces an increase in the pro-inflammatory cytokines TNFalpha and IL-1beta and a dramatic increase in the inflammation responsive cytokine IL-6 . This is balanced by the release of cytokine inhibitors ( IL-1ra , sTNF-r1 and sTNF-r2 ) and the anti-inflammatory cytokine IL-10 . The study suggests that cytokine inhibitors and anti-inflammatory cytokines restrict the magnitude and duration of the inflammatory response to exercise
A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?