There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Enhanced feeding in very-low-birth-weight infants may cause electrolyte disturbances and septicemia--a randomized, controlled trial.
BACKGROUND & AIMS High supply of protein and energy has been introduced to very-low-birth-weight infants to improve growth and cognitive development . The aim of this study was to compare two different feeding strategies on postnatal growth and clinical outcome during neonatal hospitalization . METHODS Fifty very-low-birth-weight infants were r and omized to either an enhanced or a st and ard feeding protocol within 24 h after birth . Chi-square and T-tests were applied . RESULTS First week protein , fat and energy supply was significantly higher in the intervention group compared to the control group ( all P < 0.001 ) . After inclusion of 50 patients we observed a higher occurrence of septicemia in the intervention group , 63 % vs. 29 % ( P = 0.02 ) , and no more patients were included . The infants in the intervention group demonstrated improved postnatal growth , but they also disclosed significant electrolyte deviations during the first week of life with hypophosphatemia , hypokalemia and hypercalcemia . First week phosphate nadir was lower in the infants experiencing septicemia ( 1.23 ( 0.50 ) mmol/L ) as compared to the infants without ( 1.61 ( 0.61 ) mmol/L ) ( P = 0.03 ) . CONCLUSION Our study implies that enhanced feeding may induce electrolyte imbalances in VLBW infants , and that deleterious side effects similar to those seen in refeeding syndrome may occur . Clinical Trials.gov , number NCT01103219 and the EudraCT number is 2010 - 020464 - 38
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .