RESULTS There is sufficient evidence for a Grade A recommendation of the use of olanzapine plus fluoxetine at reducing depressive symptoms in bipolar depression and of quetiapine at high doses for depressive symptoms occurring during mixed episodes .
These results mostly overlap with the approved treatments for bipolar depression in adults
BACKGROUND The management of depressive and mixed symptoms in children and adolescents with bipolar disorder ( BD ) remains a matter of debate .
The goal of this review is , thus , to systematic ally examine the impact of atypical antipsychotics ( AAPs ) and mood stabilisers in the treatment of bipolar depression and /or mixed states .
Combination lithium and divalproex sodium in pediatric bipolar symptom re-stabilization.
OBJECTIVE It has been reported that bipolar disorder may become less responsive to previously effective treatment with each symptomatic relapse . The primary goal of this study was to assess the rate of re-stabilization after the resumption of lithium ( Li ) plus divalproex ( DVPX ) following relapse on either agent as monotherapy . METHOD This is a prospect i ve , 8-week , open-label outpatient Li/DVPX combination therapy trial . Patients ages 5 to 17 years with bipolar disorder type I or II , who had achieved symptom remission with Li/DVPX combination therapy and subsequently relapsed during treatment with Li or DVPX monotherapy were enrolled between January 1999 and January 2003 . RESULTS Thirty-eight patients with a mean age of 10.5 years entered the study . Thirty-four ( 89.5 % ) patients responded to treatment with Li/DVPX mood stabilizer therapy alone , but four patients required adjunctive antipsychotic treatment to address residual symptomatology . Overall , reinitiation of Li/DVPX combination therapy was well tolerated with no subjects discontinuing because of a medication-related adverse event . CONCLUSIONS It appears that most youths with bipolar disorder who stabilize on combination Li/DVPX therapy and subsequently relapse during monotherapy can safely and effectively be re-stabilized with the reinitiation of Li/DVPX combination treatment
RESULTS There is sufficient evidence for a Grade A recommendation of the use of olanzapine plus fluoxetine at reducing depressive symptoms in bipolar depression and of quetiapine at high doses for depressive symptoms occurring during mixed episodes .
These results mostly overlap with the approved treatments for bipolar depression in adults
BACKGROUND The management of depressive and mixed symptoms in children and adolescents with bipolar disorder ( BD ) remains a matter of debate .
The goal of this review is , thus , to systematic ally examine the impact of atypical antipsychotics ( AAPs ) and mood stabilisers in the treatment of bipolar depression and /or mixed states .