RESULTS Weight loss was associated with a decline in CRP level .
Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level
BACKGROUND Several studies suggest that weight loss reduces C-reactive protein ( CRP ) level ; however , the consistency and magnitude of this effect has not been well characterized .
Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level .
Survey of C-reactive protein and cardiovascular risk factors in apparently healthy men.
Several prospect i ve studies have demonstrated a direct association between C-reactive protein ( CRP ) levels and the risks of developing cardiovascular disease . Few studies , however , have explored the interrelations between CRP levels and other risk factors for cardiovascular disease . We evaluated the relation of CRP with several cardiovascular risk factors in a cross-sectional survey of 1,172 apparently healthy men . There were significant positive associations between  CRP levels and age , number of cigarettes smoked per day , body mass index , systolic and diastolic blood pressure , total cholesterol , triglycerides , lipoprotein(a ) , apolipoprotein B , tissue-type plasminogen activator antigen ,  D-dimers  , total homocysteine , and fibrinogen ( all p values < 0.05 ) . Significant inverse associations were observed for exercise frequency , high-density lipoprotein cholesterol , and apolipoprotein A-I and A-II ( all p values < 0.02 ) . In multivariate analysis , age , smoking status , and serum levels of tissue-type plasminogen activator antigen , fibrinogen , lipoprotein(a ) , and total homocysteine were independent correlates of CRP levels . Finally , in an analysis controlled either for all the independent correlates or for several usual risk factors , we observed progressive increases in levels of CRP with increasing prevalence of risk factors ( p for trend < 0.001 for independent correlates and < 0.01 for usual risk factors ) . In conclusion , in a large cohort of apparently healthy men ,  CRP levels were associated with several cardiovascular risk factors . These data are compatible with the hypothesis that  CRP levels may be a marker for pre clinical cardiovascular disease
RESULTS Weight loss was associated with a decline in CRP level .
Our results suggest that weight loss may be an effective nonpharmacologic strategy for lowering CRP level
BACKGROUND Several studies suggest that weight loss reduces C-reactive protein ( CRP ) level ; however , the consistency and magnitude of this effect has not been well characterized .
Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level .