For example , mammography screening does not seem to create anxiety in women who are given a clear result after a mammogram .
The incidence of breast cancer and mortality increases with age , and the GDG extrapolated that the absolute health benefits are greater in women aged 45 to 49 than those aged 40 to 44 years .
However , for the 45- to 49-year age group , the higher breast cancer incidence and mortality compared with women between the ages of 40 and 44 , as well as observational evidence showing a greater benefit in this age group ( 33 ) , led the GDG to judge that the balance of health effects probably favors screening , although the required re sources for screening likely differ across setting s ( 34 , 35 ) .
Other EtD criteria also were generally in favor of implementing organized mammography screening in this age group .
Despite intensified efforts by the European Council since 2003 , the implementation of organized , population -based mammography screening is not uniform across Europe and depends greatly on the policies in place in different countries , the organization of health care , and available re sources ( 1 ) .
Since the last edition of the European Guidelines on Breast Cancer Screening and Diagnosis was published in 2006 ( 2 ) , new evidence regarding breast cancer and innovation in guideline methodology prompted the European Commission Initiative on Breast Cancer ( ECIBC ) to develop new evidence -based recommendations ( in short , the European Breast Guidelines ) .
These guidelines inform women , health professionals , and policymakers about important questions related to organized mammography screening and breast cancer diagnosis , but recommendations may apply in context s in which organized screening programs are not in place .
Women generally consider these undesirable effects acceptable ( low certainty of evidence ) , and a systematic review suggested that women place a relatively low value on the psychosocial and physical effects of false-positive results and overdiagnosis ; however , some studies raised concerns about whether women fully underst and the result ing implication s ( 15 ) .
How Often Should Women Attend an Organized Mammography Screening Program ?
Performance of breast cancer screening using digital breast tomosynthesis: results from the prospective population-based Oslo Tomosynthesis Screening Trial
Purpose Digital breast tomo synthesis ( DBT ) has the potential to overcome limitations of conventional mammography . This study investigated the effects of addition of DBT on  interval and detected cancers in population -based screening . Methods Oslo Tomo synthesis Screening Trial ( OTST ) was a prospect i ve , independent double-reading trial inviting women 50–69 years biennially , comparing full-field digital mammography ( FFDM ) plus DBT with FFDM alone .  Performance indicators and characteristics of screen-detected and interval cancers were compared with two previous FFDM rounds . Results 24,301 consenting women underwent FFDM + DBT screening over a 2-year period . Results were compared with 59,877 FFDM examinations during prior rounds . Addition of DBT result ed in a non-significant increase in sensitivity ( 76.2 % , 378/496 , vs. 80.8 % , 227/281 , p = 0.151 ) and a significant increase in specificity ( 96.4 % , 57229/59381 vs. 97.5 % , 23427/24020 , p < .001 ) . Number of recalls per screen-detected cancer decreased from 6.7 ( 2530/378 ) to 3.6 ( 820/227 ) with DBT ( p < .001 ) . Cancer detection per 1000 women screened increased ( 6.3 , 378/59877 , vs. 9.3 , 227/24301 , p < .001 ) . Interval cancer rate per 1000 screens for FFDM + DBT remained similar to previous FFDM rounds ( 2.1 , 51/24301 vs. 2.0 , 118/59877 , p = 0.734 ) . Interval cancers post-DBT were comparable to prior rounds but significantly different in size , grade , and node status from cancers detected only using DBT . 39.6 % ( 19/48 ) of interval cancers had positive nodes compared with only 3.9 % ( 2/51 ) of additional DBT-only-detected cancers . Conclusions DBT-supplemented screening result ed in significant increases in screen-detected cancers and specificity . However , no significant change was observed in the rate , size , node status , or grade of interval cancers . Clinical Trials.gov : NCT01248546
For example , mammography screening does not seem to create anxiety in women who are given a clear result after a mammogram .
The incidence of breast cancer and mortality increases with age , and the GDG extrapolated that the absolute health benefits are greater in women aged 45 to 49 than those aged 40 to 44 years .
However , for the 45- to 49-year age group , the higher breast cancer incidence and mortality compared with women between the ages of 40 and 44 , as well as observational evidence showing a greater benefit in this age group ( 33 ) , led the GDG to judge that the balance of health effects probably favors screening , although the required re sources for screening likely differ across setting s ( 34 , 35 ) .
Other EtD criteria also were generally in favor of implementing organized mammography screening in this age group .
Despite intensified efforts by the European Council since 2003 , the implementation of organized , population -based mammography screening is not uniform across Europe and depends greatly on the policies in place in different countries , the organization of health care , and available re sources ( 1 ) .
Since the last edition of the European Guidelines on Breast Cancer Screening and Diagnosis was published in 2006 ( 2 ) , new evidence regarding breast cancer and innovation in guideline methodology prompted the European Commission Initiative on Breast Cancer ( ECIBC ) to develop new evidence -based recommendations ( in short , the European Breast Guidelines ) .
These guidelines inform women , health professionals , and policymakers about important questions related to organized mammography screening and breast cancer diagnosis , but recommendations may apply in context s in which organized screening programs are not in place .
Women generally consider these undesirable effects acceptable ( low certainty of evidence ) , and a systematic review suggested that women place a relatively low value on the psychosocial and physical effects of false-positive results and overdiagnosis ; however , some studies raised concerns about whether women fully underst and the result ing implication s ( 15 ) .
How Often Should Women Attend an Organized Mammography Screening Program ?