Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Effects of a 12-month moderate weight loss intervention on insulin sensitivity and inflammation status in nondiabetic overweight and obese subjects.
Weight loss intervention is the principal non-pharmacological method for prevention and treatment of type 2 diabetes . However , little is known whether it influences insulin sensitivity directly or via its anti-inflammatory effect . The aim of this study was to assess the independent role of changes in inflammation status and weight loss on insulin sensitivity in this population .Overweight and obese nondiabetic participants without co-morbidities underwent a one-year weight loss intervention focused on caloric restriction and behavioral support . Markers of inflammation , body composition , anthropometric para-meters , and insulin sensitivity were recorded at baseline , 6 , and 12 months . Insulin sensitivity was assessed with frequently sample d intravenous glucose tolerance test and Minimal Model . Twenty-eight participants ( F : 15 , M : 13 , age 39±5 years , BMI 33.2±4.6 kg/m(2 ) ) completed the study , achieving 9.4±6.9 % weight loss , which was predominantly fat mass ( 7.7±5.6 kg , p<0.0001 ) . Dietary intervention result ed in significant decrease in leptin , leptin-to-adiponectin ratio , hs-CRP , and IL-6 ( all p<0.02 ) , and improvement in HOMA-IR and Insulin Sensitivity Index ( SI ) ( both p<0.001 ) . In response to weight loss IL-1β , IL-2 , leptin , and resistin were significantly associated with insulin , sensitivity , whereas sICAM-1 had only marginal additive effect . Moderate weight loss in otherwise healthy overweight and obese individuals result ed in an improvement in insulin sensitivity and in the overall inflammation state ; the latter played only a minimal independent role in modulating insulin sensitivity
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .