Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
No effect of atorvastatin and simvastatin on oxidative stress in patients at high risk for cardiovascular disease.
BACKGROUND Statins are thought to have anti-atherogenic effects beyond cholesterol lowering . One such mechanism may involve reduction of oxidative stress . The aim of our study was to investigate and to compare the oxidative stress lowering capacity of atorvastatin with that of simvastatin in patients at high risk for cardiovascular disease using conventional markers and sensitive markers measured by highly specific techniques such as liquid chromatography t and em mass spectrometry . METHODS We included 30 statin-naive patients with diabetes mellitus , and /or obesity , and /or hypertension ( 12 male , 18 female , mean age 44.8±11.1 years ) , and r and omised them to receive either atorvastatin 10 mg or simvastatin 40 mg daily to obtain an equimolar cholesterol reduction . Blood and urine sample s were obtained at baseline and at 1 , 6 and 12 weeks . RESULTS Low-density lipoprotein ( LDL ) cholesterol and coenzyme Q10 decreased significantly in both groups . Simvastatin caused a faster initial LDL cholesterol lowering  than atorvastatin ( p=0.01 ) , but the overall effect after 12 weeks of atorvastatin and simvastatin was similar . Plasma myeloperoxidase and malondialdehyde did not change during the study period in the two groups . Urinary F2-isoprostanes decreased gradually and significantly in the atorvastatin group but not in the simvastatin group , but the between-group difference was not significant . Urinary 8-hydroxy-2-deoxyguanosine did not change in the two groups
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .