The results of meta- analysis showed statistically significant differences between aloe vera and control groups in alleviating pain/burning sensation at the end of the first and second month , in favor of aloe vera , but no significant differences were found at the end of the third month .
With regard to objective clinical outcomes , no statistically significant differences were found between the groups .
Aloe vera has a promising effect in reducing pain/burning sensation and clinical improvement in patients with OSF .
The management of oral submucous fibrosis ( OSF ) is quite challenging , and as yet , no effective therapy is available for its management .
The present systematic review and meta- analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF .
Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial.
OBJECTIVES To evaluate and compare the therapeutic response of lycopene and curcumin with placebo in patients suffering from oral submucous fibrosis ( OSMF ) and to correlate the habit variables of smoked and smokeless tobacco products in OSMF . METHODS A r and omized placebo-controlled parallel clinical study was conducted on ninety OSMF patients , who were divided into three treatment groups using computer-generated r and omization . Group A patients ( n = 30 ) were given curcumin tablet ( 300 mg ) twice daily , Group B patients ( n = 30 ) received lycopene capsules ( 8 mg ) twice daily , and for Group C ( n = 30 ) , placebo capsules were given once daily for a period of six months . Both the participant and outcome assessor were blinded . Pre- and post-treatment comparison of mouth opening , burning sensation , tongue protrusion , and cheek flexibility was analyzed at periodic follow-up of 9 months . RESULTS The overall improvement in mouth opening , burning sensation , tongue protrusion , and cheek flexibility was 3.9 ± 4.9 mm , 4.8 ± 2.6 , 5.0 ± 7.2 mm , & 0.36 ± 0.71 mm , respectively , for curcumin and 4.1 ± 4.2 mm , 5.0 ± 2.3 , 2.4 ± 3.5 mm , & 0.66 ± 0.80 mm , respectively , for lycopene with the p value < 0.05 . CONCLUSION Statistically significant improvement in clinical findings was observed in both curcumin and lycopene treatment groups in comparison with placebo . However , the therapeutic efficacy of curcumin and lycopene was found to be almost equal in OSMF patients
The results of meta- analysis showed statistically significant differences between aloe vera and control groups in alleviating pain/burning sensation at the end of the first and second month , in favor of aloe vera , but no significant differences were found at the end of the third month .
With regard to objective clinical outcomes , no statistically significant differences were found between the groups .
Aloe vera has a promising effect in reducing pain/burning sensation and clinical improvement in patients with OSF .
The management of oral submucous fibrosis ( OSF ) is quite challenging , and as yet , no effective therapy is available for its management .
The present systematic review and meta- analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF .