Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Calcium and vitamin D intakes in children: a randomized controlled trial
Background Calcium ( Ca2 + ) and vitamin D ( VitD ) play an important role in child health . We evaluated the daily intake of Ca2 + and VitD in healthy children . Moreover , we demonstrate the efficacy of Ca2 + and VitD supplementation . Methods Daily Ca2 + and VitD intake was evaluated in consecutive healthy children through a vali date d question naire . Subjects with < 70 % of dietary reference intakes ( DRIs ) of Ca2 + and VitD were invited to participate in a prospect i ve r and omized trial with 2 groups of nutritional intervention : Group 1 , dietary counseling aim ing to optimize daily Ca2 + and VitD intake plus administration of a commercially available Ca2 + and VitD supplementation product ; Group 2 , dietary counseling alone . At the enrollment ( T0 ) and after 4 months ( T1 ) serum 25(OH ) Vitamin D levels were assessed . Results We evaluated 150 healthy children ( male 50 % , mean age 10 years ) ; at baseline a  low VitD intake  was observed in all subjects ( median 0.79 μg/die , IQR 1.78 ; range 0.01 - 5.02 ) ; this condition was associated with Ca2 + intake < 70 % of the DRIs in 82 subjects ( 55 % ) . At baseline serum 25(OH)D levels were low ( < 30 ng/ml ) in all study subjects and after 4 months of nutritional intervention , a normalization of serum 25(OH)D levels ( ≥30 ng/ml ) was observed in all children in Group 1 and in only one subject in Group 2 [ Group 1 : T1 33.8 ng/ml ( IQR 2.5 ) vs Group 2 : T1 24.5 ng/ml ( IQR 5.2 ) , p < 0.001 ] . Conclusions Adequate Ca2 + and VitD intakes are difficult to obtain through dietary counseling alone in pediatric subjects . Oral supplementation with of Ca2 + and VitD is a reliable strategy to prevent this condition . Trial registration The study was registered in Clinical Trials Protocol Registration System ( ID number : NCT01638494 )
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .