Lifestyle coping behaviours therefore have a significant contribution to AL .
This study is among the first to explore multiple domains of HRB in relation to AL .
Health risk behaviours ( HRB ) across the lifespan have been associated with higher cumulative physiological burden as measured by allostatic load ( AL ) .
This study examines the contribution of HRB and their effects on multisystem biological risk associated with morbidity and early mortality .
Serum electrolyte, serum protein, serum fat and renal responses to a dietary sodium challenge: Allostasis and allostatic load
Objective : The purpose of this study was to assess , in borderline hypertensive subjects , the homeostatic and allostatic responses of serum electrolytes , proteins , lipids , hematocrit and renal function to an extreme dietary sodium challenge , and to evaluate whether the responses in these clinical parameters were associated with a concomitant response in blood pressure . Subjects and methods : Data from middle-aged adults with a diagnosis of mild , uncomplicated borderline hypertension were collected at the end of 1-month r and omized trials of low ( 24 ± 13 mmol/day ) and high ( 309 ± 88 mmol/day ) dietary sodium intake . A total of 48 subjects ( 38 men and 10 women ) were examined . Results : Serum sodium increased ( p<0.001 ) , while all other serum electrolytes , except chloride , decreased ( p<0.01 ) from the low to high sodium diets . Serum proteins ( p<0.05 ) and hematocit ( p<0.001 ) also declined among subjects on a high sodium diet . However , creatinine clearance ( an indicator of glomerular filtration ) increased with sodium intake ( p = 0.004 ) . None of these biochemical or renal functional responses was associated with a change in blood pressure . Conclusion : There are modest yet significant changes in serum electrolytes associated with changes in dietary sodium intake , suggesting that these ions are under an allostatic control mechanism . Serum proteins also appear to function as allostatic compensatory mechanisms , off setting the net effect of increased serum salinity . It is speculated that the adaptive allostatic renal response to a high sodium diet ( an increase in GFR ) may result in loss of the ability to appropriately vary renal filtration if that diet is chronically maintained
Lifestyle coping behaviours therefore have a significant contribution to AL .
This study is among the first to explore multiple domains of HRB in relation to AL .
Health risk behaviours ( HRB ) across the lifespan have been associated with higher cumulative physiological burden as measured by allostatic load ( AL ) .
This study examines the contribution of HRB and their effects on multisystem biological risk associated with morbidity and early mortality .