There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Synthesis of long-chain polyunsaturated fatty acids in preterm newborns fed formula with long-chain polyunsaturated fatty acids.
BACKGROUND Docosahexaenoic acid ( DHA ) and arachidonic acid ( AA ) are long-chain polyunsaturated fatty acids ( LCPs ) that play pivotal roles in growth and neurodevelopment . OBJECTIVE We aim ed to quantify the synthesis of LCPs in preterm infants fed infant formula containing LCPs . DESIGN Twenty-two preterm infants were r and omly assigned to either the no-LCP group ( fed formula without LCPs ; n = 11 ) or the LCP group ( fed formula with LCPs ; n = 11 ) . Dietary LCPs had higher (13)C content than did the endogenously synthesized LCPs , which were derived from linoleic and alpha-linolenic acids . The (13)C content of major selected plasma fatty acids was measured by using gas chromatography-isotope ratio mass spectrometry at birth and at age 1 , 3 , and 7 mo . Absolute LCP synthesis and the percentage of LCP synthesis relative to dietary intake were calculated . RESULTS Percentage AA synthesis was 67.2 + /- 7.8 % , 35.9 + /- 9.8 % , and 29.0 + /- 10.3 % , and that of DHA was 41.7 + /- 14.9 % , 10.5 + /- 8.1 % , and 7.4 + /- 6.2 % at 1 , 3 , and 7 mo old , respectively . Absolute AA synthesis was 26.7 + /- 4.2 , 14.4 + /- 3.9 , and 11.6 + /- 4.1 mg x kg(-1 ) x d(-1 ) and that of DHA was 12.6 + /- 4.5 , 3.2 + /- 2.5 , and 2.3 + /- 1.9 mg x kg(-1 ) . d(-1 ) at 1 , 3 , and 7 mo old , respectively . AA and DHA synthesis decreased significantly ( P < 0.01 ) with time , and AA synthesis was significantly ( P < 0.01 ) greater than DHA synthesis . CONCLUSIONS By this novel approach , we measured endogenous LCP synthesis in infants receiving dietary LCPs over long periods . By age 7 mo , LCP synthesis was dramatically lower in preterm infants fed LCPs
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .