A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?
Resistance training does not protect against increases in plasma cytokine levels among germ cell cancer patients during and after chemotherapy.
CONTEXT Testicular germ cell cancer ( GCC ) patients treated with cisplatin-etoposide-bleomycin chemotherapy ( BEP )  have excellent prognosis but have an increased risk of late-occurring morbidities , which may be associated with changes in the inflammatory profile . OBJECTIVE The objective of the study was to explore plasma cytokine concentrations in GCC patients r and omized to resistance training or usual care during BEP , in comparison with healthy controls . DESIGN / SETTING This was a r and omized controlled trial in GCC patients enrolled from an oncology clinic , including a healthy reference group for comparison purpose s. OUTCOME MEASURES Plasma granulocyte macrophage colony-stimulating factor , interferon-γ , IL-1β , IL-2 , IL-6 , IL-8 , IL-10 , IL-12 , and TNF-α were measured in fasting blood sample s from GCC patients r and omized to resistance training ( INT ; n = 15 ) or usual care ( CON ; n = 15 ) and healthy age-matched controls ( REF ; n = 19 ) . Clinical toxicity assessment s and patient-reported end points were also recorded . RESULTS CON and INT were balanced at baseline . Compared with REF , CON had higher concentrations of IL-10 , IL-6 , and interferon-γ , and INT had higher concentrations of IL-6 , IL-8 and TNF-α ( all P < .05 ) . At the end of therapy , concentrations of IL-6 , IL-8 , and IL-10 increased in both GCC groups ( all P < .01 ) . Three months after therapy , all cytokine concentrations were comparable with the pretreatment levels in both GCC-groups but remained elevated compared with REF ( P < .05 ) . Changes in TNF-α correlated with pulmonary toxicity ( P < .01 ) . At the end of therapy , IL-6 concentrations correlated with quality of life ( P < .05 ) and fatigue ( P < .01 ) . CONCLUSION GCC patients treated with BEP display consistently elevated levels of systemic inflammatory markers compared with healthy controls . Resistance training during therapy has no impact on plasma cytokine concentrations
A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?