These drugs were better tolerated than tricyclics and benzodiazepines as they had a low risk of dependence and overdosing complications .
The serotonergic , noradrenergic and GABAergic pathways play a major role in the fear network and in the physiopathology of PD .
INTRODUCTION Panic disorder ( PD ) is a prevalent psychiatric disorder characterized by unexpected and recurrent panic attacks .
PD patients present significant psychosocial impairment and a high risk of psychiatric comorbidities and suicide .
PD should be treated effectively as soon as the symptoms emerge because the longer these patients remain without treatment , the worse the prognosis will be .
SSRIs and SNRIs are the first-line compounds in the treatment of PD .
Double-blind comparison of 30 and 60 mg tranylcypromine daily in patients with panic disorder comorbid with social anxiety disorder
Our objective was to explore the dose-response relationship in patients with panic disorder and social anxiety disorder comorbidity ( DSM-IV ) . After 1 week of no-drug washout , 36 such patients were assigned to a double-blind controlled comparison of the effects of 30 mg and 60 mg of tranylcypromine , and were followed up for 12 weeks . The main instrument used to measure the number of panic attacks was the Sheehan Panic and Anticipatory Anxiety Scale . The primary outcome measure for social anxiety disorder symptoms was the mean change from baseline in the Liebowitz Social Anxiety Scale ( LSAS ) . After 12 weeks of treatment , panic attacks were reduced 69.6 % from baseline in the 30-mg group ( n=19 ) compared with a 74.8 % reduction in the 60-mg group ( n=17 ) . Twelve patients ( 70.6 % ) of the higher dose group and 14 patients ( 68.4 % ) of the lower dose were completely free of panic attacks . There was no difference in efficacy between the tranylcypromine groups in the panic disorder symptoms . The 60-mg dose was more efficacious as measured by the LSAS scores , showing a significant difference in relation to the lower group . Mean change from baseline in LSAS total score ( mean+/-SD ) for 30-mg group was 17.9+/-14.7 and for the 60-mg group was 35.0+/-14.8 . The social anxiety symptom scale showed a two-fold greater change with the 60-mg dose , and the 30-mg dose group could be considered the equivalent of a placebo control group . Tranylcypromine--60 mg daily -- was found effective in the treatment of panic disorder and social anxiety disorder comorbidity
These drugs were better tolerated than tricyclics and benzodiazepines as they had a low risk of dependence and overdosing complications .
The serotonergic , noradrenergic and GABAergic pathways play a major role in the fear network and in the physiopathology of PD .
INTRODUCTION Panic disorder ( PD ) is a prevalent psychiatric disorder characterized by unexpected and recurrent panic attacks .
PD patients present significant psychosocial impairment and a high risk of psychiatric comorbidities and suicide .
PD should be treated effectively as soon as the symptoms emerge because the longer these patients remain without treatment , the worse the prognosis will be .
SSRIs and SNRIs are the first-line compounds in the treatment of PD .