In the meta- analysis , tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates .
However , compared with sildenafil , tadalafil significantly improved psychological outcomes .
Furthermore , the patients and their partners preferred tadalafil over sildenafil , and no significant difference was found in the adherence and persistence rates between tadalafil and sildenafil .
Additionally , the myalgia and back pain rates were higher and the flushing rate was lower with tadalafil than with sildenafil .
Conclusion Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients ’ sexual confidence .
Furthermore , patients and their partners prefer tadalafil to sildenafil .
Hence , tadalafil may be a better choice for ED treatment
Aims Erectile dysfunction ( ED ) is a major care problem worldwide .
Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED .
This systematic review and meta- analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED .
Efficacy of Tadalafil De-Escalation in the Treatment of Psychogenic Erectile Dysfunction
Objectives : To assess the efficacy of tadalafil de-escalation in the therapeutic effects of psychogenic erectile dysfunction ( ED ) during the 3 months extension phase . Methods : A total of 90 men with mild to severe psychogenic ED were r and omly divided into 2 groups : tadalafil 5 mg group and tadalafil de-escalation group . Efficacy assessment s included the 5-item version of International Index of Erectile Function ( IIEF-5 ) , the Sexual Encounter Profile ( SEP ) question naires , Psychological and Interpersonal Relationship Scales ( PAIRS ) , Erection Hardness Score ( EHS ) . Results : Compared with the baseline , tadalafil 5 mg and de-escalation groups enhanced all efficacy outcomes . Patients receiving tadalafil 5 mg and de-escalation experienced a significant mean improvement in the psychogenic erectile function domain of the IIEF-5 from the baseline ( p < 0.01 ) . The mean change from baseline was significantly higher for the tadalafil de-escalation group than for the tadalafil 5 mg group ( p < 0.05 ) . Response to SEP3 , PAIRS and EHS was significantly higher in the tadalafil de-escalation group than in the tadalafil 5 mg group ( p < 0.05 ) . The severity of ED in the tadalafil de-escalation group had reduced after treatment . It was also significantly better than those in the tadalafil 5 mg group ( p < 0.05 ) . Conclusion : Tadalafil de-escalation significantly improved the erectile function among psychogenic ED patients . This implies that tadalafil de-escalation treatment for psychogenic ED is worthy of further clinical practice and research
In the meta- analysis , tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates .
However , compared with sildenafil , tadalafil significantly improved psychological outcomes .
Furthermore , the patients and their partners preferred tadalafil over sildenafil , and no significant difference was found in the adherence and persistence rates between tadalafil and sildenafil .
Additionally , the myalgia and back pain rates were higher and the flushing rate was lower with tadalafil than with sildenafil .
Conclusion Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients ’ sexual confidence .
Furthermore , patients and their partners prefer tadalafil to sildenafil .
Hence , tadalafil may be a better choice for ED treatment
Aims Erectile dysfunction ( ED ) is a major care problem worldwide .
Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED .
This systematic review and meta- analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED .