Therefore , vitamin A supplementation alone may reduce the risk of anemia , by improving hemoglobin and ferritin levels in individuals with low serum retinol levels
ABSTRACT Anemia is a worldwide public health problem that can be related to many causes , including vitamin A deficiency .
The aim of this study was to assess and estimate the effect of vitamin A supplementation ( VAS ) on iron status biomarkers and anemia in humans .
No enhancing effect of vitamin A administration on iron absorption or body total iron content in preschool children from Chengdu, China.
To explore the effect of vitamin A supplements on iron metabolic homeostasis for preschoolers . This was a r and omized , placebo-controlled and blinded intervention trial with 3- to 6-y old preschoolers . A total of 445 subjects were r and omly divided into four groups : a vitamin A supplementation group ( group 1 , a single oral dose of vitamin A as retinol 200,000 IU ) , an iron supplement group ( group 2 , daily oral supplement with the elemental iron 1 - 2 mg/kg/d for 5 d a week , lasting for 6 mo ) a combined vitamin A and iron ( group 3 ) and administration of no vitamin A or iron as a placebo-control ( group 4 ) . A total of 387 ( 95 , 98 , 90 and 104 from groups 1 , 2 , 3 and 4 ) children completed the intervention . After intervention , serum retinol levels of children in group 1 and group 3 was markedly higher than those of children in groups 2 and 4 ( p<0.05 ) . The serum ferritin level of children in group 1 significantly decreased after intervention ( p<0.05 ) , but increased in group 2 ( p<0.05 ) . The sTfR-SF index ( TFR-F ) and total body iron content ( BTIC ) showed the same change after intervention . In group 2 and group 3 , the levels of TRF-F index and BTIC had statistically increased to the same degree after intervention ( p<0.05 ) . The impact of vitamin A intervention on iron metabolic homeostasis was mainly manifested in storage and mobilization ; there was no direct effect on total body iron content or iron absorption in the intestine
Therefore , vitamin A supplementation alone may reduce the risk of anemia , by improving hemoglobin and ferritin levels in individuals with low serum retinol levels
ABSTRACT Anemia is a worldwide public health problem that can be related to many causes , including vitamin A deficiency .
The aim of this study was to assess and estimate the effect of vitamin A supplementation ( VAS ) on iron status biomarkers and anemia in humans .