Fermented formula has the potential to reduce some , albeit not well-defined , digestive symptoms .
Current evidence does not support the use of fermented formula for preventing cow ’s milk allergy .
Conclusion : Limited available evidence suggests that the use of fermented infant formula , compared with the use of st and ard infant formula , does not offer clear additional benefits , although some benefit on gastrointestinal symptoms can not be excluded .
What is new• Limited evidence available suggests that the use of fermented infant formula , compared with the use of st and ard infant formula , does not offer clear additional benefits , although some benefit on gastrointestinal symptoms can not be excluded .
At the same time , no negative health effects have been documented
Abstract Fermented formulas , i.e. , those fermented with lactic acid-producing bacteria during the production process and not containing significant amounts of viable bacteria in the final product , are widely available in many countries .
Our aim was to systematic ally review published evidence related to the safety and health effects of the administration of fermented infant formulas compared with st and ard infant formulas .
A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy
Background / Objectives : To determine the impact of a not hydrolyzed fermented infant formula containing heat-killed Bifidobacterium breve C50 and Streptococcus thermophilus 065 ( HKBBST ) on the incidence of allergy-like events during the first 2 years of life in children at high risk of atopy . Subjects/ Methods : This multicenter , r and omized , double-blind , controlled study included infants at high risk of atopy . Infants used HKBBST or a st and ard infant formula ( SIF ) since birth until 1 year of age , and were followed at 4 , 12 and 24 months after birth .  Skin prick tests ( SPTs ) for six foods and six aeroallergens were systematic ally performed and adverse events ( AEs ) were recorded . In case of potentially allergic AE ( PAAE ) , allergy could be further tested by SPT , patch tests and quantification of specific IgEs . If cow 's milk allergy ( CMA ) was suspected , an oral challenge could also be performed . Results : The study included 129 children , 63 were r and omized to SIF , 66 to HKBBST . The use of HKBBST milk did not alter the proportion of CMA but decreased the proportion of positive SPT to cow 's milk ( 1.7 vs 12.5 % , P=0.03 ) , and the incidence of digestive ( 39 vs 63 % , P=0.01 ) and respiratory potentially allergic AEs ( 7 vs 21 % , P=0.03 ) at 12 months , and that of respiratory PAAEs at 24 months ( 13 vs 35 % , P=0.01 ) . Conclusions : HKBBST decreased the incidence of PAAEs in children with family history of atopy , during the first months of life and after the formula was stopped . Oral tolerance to cow 's milk in infants at high risk of atopy may therefore be improved using not hydrolyzed fermented formulae
Fermented formula has the potential to reduce some , albeit not well-defined , digestive symptoms .
Current evidence does not support the use of fermented formula for preventing cow ’s milk allergy .
Conclusion : Limited available evidence suggests that the use of fermented infant formula , compared with the use of st and ard infant formula , does not offer clear additional benefits , although some benefit on gastrointestinal symptoms can not be excluded .
What is new• Limited evidence available suggests that the use of fermented infant formula , compared with the use of st and ard infant formula , does not offer clear additional benefits , although some benefit on gastrointestinal symptoms can not be excluded .
At the same time , no negative health effects have been documented
Abstract Fermented formulas , i.e. , those fermented with lactic acid-producing bacteria during the production process and not containing significant amounts of viable bacteria in the final product , are widely available in many countries .
Our aim was to systematic ally review published evidence related to the safety and health effects of the administration of fermented infant formulas compared with st and ard infant formulas .