The review of trials identifies positive effects of these nutrients on various outcome measures relating to insulin resistance and cardiovascular factors .
A majority of the trials found a positive effect of chromium on fasting plasma glucose .
Isoflavones were found to have a positive effect on insulin resistance and cardiovascular outcome measures , but only when combined with soy proteins .
Vitamin E is reported to reduce oxidative stress at levels of 200 mg day(-1 ) or more
The role of nutritional supplementation is of increasing interest with regard to ocular disease .
R and omised controlled trials have demonstrated the effectiveness of supplementation for age-related macular degeneration , and formulations are now being developed for use by people with diabetes and diabetic retinopathy .
The aim of this review was to synthesis e the evidence for use of nutritional supplementation in type 2 diabetes .
The potential role of alpha-lipoic acid , chromium , folic acid , isoflavones , magnesium , Pycnogenol , selenium , vitamin C , vitamin E , and zinc in the treatment of type 2 diabetes is discussed .
Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus.
BACKGROUND We investigated the potential effects of chromium supplementation on QTc interval duration in type 2 diabetic patients . METHODS Of 60 patients with type 2 diabetes mellitus , 30 were r and omly assigned to group A , and 30 to group B. Group A received 1000 microg of chromium picolinate ( CrPic ) daily for 3 months , followed by placebo in the next 3 months ; group B was treated with placebo for the first 3 months and CrPic in the next 3 months . At each visit , QT interval was measured on a  st and ard electrocardiogram  by averaging 3 consecutive beats in leads II and V4 and corrected for heart rate with Bazett formula . RESULTS Although baseline QTc interval was similar in both groups ( 422 + /- 34 milliseconds in group A vs 425 + /- 24 milliseconds in group B , P = .77 ) , QTc interval at 3 months was shorter in group A ( 406 + /- 35 milliseconds ) than in group B ( 431 + /- 26 milliseconds , P = .01 ) . In the following 3 months , QTc interval shortened in group B but not in group A , which result ed in a comparable QTc interval duration of both groups at the end of the study ( 414 + /- 28 milliseconds in group A vs 409 + /- 22 milliseconds in group B , P = .50 ) . Apart from body mass index ( 31.4 + /- 4.2 kg/m2 in patients with QTc shortening vs 28.7 + /- 4.2 kg/m2 in patients without QTc shortening , P = .03 ) , none of the clinical and laboratory variables predicted QTc interval shortening in our patient cohort . CONCLUSIONS Short-term chromium supplementation shortens QTc interval in patients with type 2 diabetes mellitus
The review of trials identifies positive effects of these nutrients on various outcome measures relating to insulin resistance and cardiovascular factors .
A majority of the trials found a positive effect of chromium on fasting plasma glucose .
Isoflavones were found to have a positive effect on insulin resistance and cardiovascular outcome measures , but only when combined with soy proteins .
Vitamin E is reported to reduce oxidative stress at levels of 200 mg day(-1 ) or more
The role of nutritional supplementation is of increasing interest with regard to ocular disease .
R and omised controlled trials have demonstrated the effectiveness of supplementation for age-related macular degeneration , and formulations are now being developed for use by people with diabetes and diabetic retinopathy .
The aim of this review was to synthesis e the evidence for use of nutritional supplementation in type 2 diabetes .
The potential role of alpha-lipoic acid , chromium , folic acid , isoflavones , magnesium , Pycnogenol , selenium , vitamin C , vitamin E , and zinc in the treatment of type 2 diabetes is discussed .