Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .
Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus: A randomized controlled trial.
It has previously been reported that the influence of vitamin D on the metabolism of calcium and phosphorus is associated with diabetes , cardiovascular disease , Alzheimer 's disease , cancer and other systemic diseases , and is considered an important indicator of general health . The present study was conducted to determine the effect of various doses of vitamin D supplementation on glucose metabolism , lipid concentrations , inflammation and the levels of oxidative stress of pregnant women with gestational diabetes mellitus ( GDM ) . The present r and omized , double-blind placebo-controlled clinical trial was conducted on 133 pregnant women with GDM during weeks 24 - 28 of pregnancy . The patients were r and omly divided into four groups . The control group ( n=20 ) received a placebo ( sucrose ; one granule/day ) , the low dosage group ( n=38 ) received the daily recommended intake of 200 IU vitamin D ( calciferol ) daily , the medium dosage group ( n=38 ) received 50,000 IU monthly ( 2,000 IU daily for 25 days ) and the high dosage group ( n=37 ) received 50,000 IU every 2 weeks ( 4,000 IU daily for 12.5 days ) . The general characteristics and dietary intakes of the patients with GDM were similar between each group . Using ELISA kits , it was determined that insulin , homeostatic model assessment -insulin resistance and total cholesterol were significantly reduced by high dosage vitamin D supplementation ( P<0.05 ) . Total antioxidant capacity and total glutathione levels were significantly elevated as a result of high dosage vitamin D supplementation ( P<0.01 ) . In conclusion , high-dose vitamin D supplementation ( 50,000 IU every 2 weeks ) significantly improved insulin resistance in pregnant women with GDM
Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .