Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
The effects of lipid-lowering therapy on paraoxonase activities and their relationships with the oxidant–antioxidant system in patients with dyslipidemia
Background Atorvastatin , an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase , which is used for lipid-lowering therapy , is an effective statin modulating process involved in atherosclerosis . Paraoxonase ( PON ) associated with high-density lipoprotein ( HDL ) has been postulated to have a role in protecting low-density lipoprotein ( LDL ) against oxidative modification . Oxidation of serum LDL is an important early step in the development of atherosclerosis and auto-antibodies against oxidized LDL ( AuAb-oxLDL ) reflect in-vivo LDL oxidation . Design and methods To examine the effect of atorvastatin ( 10 mg/day ) therapy on PON activity in serum and HDL , the study group included 40 patients with dyslipidemia ( 19 women and 21 men ) , 25 of whom had hypercholesterolemia and of 15 of whom had mixed-type hyperlipidemia . By taking blood sample s from the patients , levels of serum lipids , lipid peroxidation product as malondialdehyde ( MDA ) , total antioxidant status ( TAS ) and AuAb-oxLDL and the activities of PON in serum and isolated HDL were determined . Results The mean levels of total cholesterol , triglyceride , LDL-cholesterol , MDA and AuAb-oxLDL were decreased while HDL-cholesterol and TAS were increased significantly after lipid-lowering therapy in patients with dyslipidemia . On the other h and , PON activities in serum and HDL were increased significantly . The percentage increase in serum PON activity was associated significantly with the percentage decrease in serum AuAb-oxLDL ( r=−0.32 , P=0.047 ) and that of HDL PON activity was associated with the percentage increase in HDL-cholesterol level after atorvastatin therapy ( r=0.52 , P=0.001 ) . The therapy was more effective in increasing PON activity in patients with HDL levels above 35 mg/dl . Conclusion It was concluded that atorvastatin therapy in dyslipidemic patients decreases the level of oxidative stress and increases PON activity , especially in patients with HDL levels above 35 mg/dl
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .