Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .
Effects of calcium–vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: a randomised placebo-controlled trial
Aims /hypothesisThis study was design ed to assess the effects of calcium and vitamin D supplementation on the metabolic status of pregnant women with gestational diabetes mellitus ( GDM ) . Methods This r and omised placebo-controlled trial was performed at maternity clinics affiliated to Kashan University of Medical Sciences , Kashan , Iran . Participants were 56 women with GDM at 24–28 weeks ’ gestation ( 18 to 40 years of age ) . Subjects were r and omly assigned to receive calcium plus vitamin D supplements or placebo . All study participants were blinded to group assignment . Individuals in the calcium – vitamin D group ( n = 28 ) received 1,000 mg calcium per day and a 50,000 U vitamin D3 pearl twice during the study ( at study baseline and on day 21 of the intervention ) , and those in the placebo group ( n = 28 ) received two placebos at the mentioned times . Fasting blood sample s were taken at study baseline and after 6 weeks of intervention . Results The study was completed by 51 participants ( calcium – vitamin D n = 25 ,  placebo n = 26 ) . However , as the analysis was based on an intention-to-treat approach , all 56 women with GDM ( 28 in each group ) were included in the final analysis . After the administration of calcium plus vitamin D supplements , we observed a significant reduction in fasting plasma glucose ( −0.89 ± 0.69 vs + 0.26 ± 0.92 mmol/l , p < 0.001 ) , serum insulin levels ( −13.55 ± 35.25 vs + 9.17 ± 38.50 pmol/l , p = 0.02 ) and HOMA-IR ( −0.91 ± 1.18 vs + 0.63 ± 2.01 , p = 0.001 ) and a significant increase in QUICKI ( + 0.02 ± 0.03 vs −0.002 ± 0.02 , p = 0.003 ) compared with placebo . In addition , a significant reduction in serum LDL-cholesterol ( −0.23 ± 0.79 vs + 0.26 ± 0.74 mmol/l , p = 0.02 ) and total cholesterol : HDL-cholesterol ratio ( −0.49 ± 1.09 vs + 0.18 ± 0.37 , p = 0.003 ) and a significant elevation in HDL-cholesterol levels ( + 0.15 ± 0.25 vs −0.02 ± 0.24 mmol/l , p = 0.01 ) was seen after intervention in the calcium – vitamin D group compared with placebo . In addition , calcium plus vitamin D supplementation result ed in a significant increase in GSH ( + 51.14 ± 131.64 vs −47.27 ± 203.63 μmol/l , p = 0.03 ) and prevented a rise in MDA levels ( + 0.06 ± 0.66 vs + 0.93 ± 2.00 μmol/l , p = 0.03 ) compared with placebo . Conclusions /interpretationCalcium plus vitamin D supplementation in women with GDM had beneficial effects on their metabolic profile . Trial registration www.i rct .ir I RCT 201311205623N11 Funding The study was supported by a grant ( no. 92110 ) from Kashan University of Medical Sciences
Overall , this meta- analysis shows that in diabetic patients , taking vitamin D had significant effects on hs-CRP and MDA levels , and significantly increased NO , TAC and GSH levels
In this systematic review and meta- analysis of r and omized controlled trials ( RCTs ) , the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized .