AND RELEVANCE Although L reuteri may be effective as treatment for crying in exclusively breastfed infants with colic , there is still insufficient evidence to support probiotic use to manage colic , especially in formula-fed infants , or to prevent infant crying .
IMPORTANCE  Excessive infant crying  is common , distressing , but without proven effective prevention or management options .
Probiotics may be a promising solution .
OBJECTIVE To examine whether probiotics are effective in the prevention/management of crying ( " colic " ) in infants 3 months or younger .
Treatment of Infantile Colic with Surface Active Substance (Simethicone)
ABSTRACT . The effect of Simethicone on  “ colicky ” ( n=27 ) infants was tested in a double‐blind cross‐over study . Three different parameters were used to measure the efficiency of the treatment : interviews , 24‐hour records and behavioral observations . No effects of Simethicone on the symptoms of infantile colic could be demonstrated . However , 67 % of the infants improved during the treatment , which could be ascribed to a high‐ grade placebo‐effect
AND RELEVANCE Although L reuteri may be effective as treatment for crying in exclusively breastfed infants with colic , there is still insufficient evidence to support probiotic use to manage colic , especially in formula-fed infants , or to prevent infant crying .
IMPORTANCE  Excessive infant crying  is common , distressing , but without proven effective prevention or management options .
Probiotics may be a promising solution .
OBJECTIVE To examine whether probiotics are effective in the prevention/management of crying ( " colic " ) in infants 3 months or younger .