Vitamin D supplementation had no statistically significant effects on total body bone mineral content or on bone mineral density of the hip or forearm .
It is unlikely that vitamin D supplements are beneficial in children and adolescents with normal vitamin D levels .
OBJECTIVE To determine the effectiveness of vitamin D supplementation for improving  bone mineral density in children and adolescents and if effects vary with factors such as vitamin D dose and vitamin D status .
ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects
A previous r and omized placebo-controlled double-blinded clinical trial revealed that treatment of osteoporotic subjects supplemented with 200 or 400IU/day vitamin D3 with 0.75 microg/day ED-71 for 12 months increased lumbar and hip bone mineral density ( BMD ) by 3.4 and 1.5 % , respectively , compared to placebo group ( JCE&M 90:5031,2005 ) . These effects on BMD were stronger than any previous results using 1alpha(OH)D3 or 1,25(OH)2D3 . However , there still was a concern that the effect of ED-71 could be observed because serum 25(OH)D in many of these subjects were below its optimal level . In order to address this issue , we performed post hoc analysis to compare the effect of ED-71 on lumbar and hip BMD between subjects with upper ( > 29 ng/mL ) and lower tertiles ( < 25 ng/mL ) of serum 25(OH)D.  Lumbar BMD after 12-month treatment with 0.5 , 0.75 and 1.0 microg/day ED-71 increased similarly in both lower and upper tertile groups of serum 25(OH)D. In addition , hip BMD also showed a tendency to increase when 0.75 and 1.0 microg/day ED-71 groups were combined together in both upper and lower serum 25(OH)D tertile groups , although the increase was not statistically significant . These results demonstrate that the effect of ED-71 on bone is independent of supplementary effect for nutritional vitamin D insufficiency , and suggest that ED-71 may exert its effect as a unique VDR lig and with stronger effect on bone compared to the natural lig and , 1,25(OH)2D3
Vitamin D supplementation had no statistically significant effects on total body bone mineral content or on bone mineral density of the hip or forearm .
It is unlikely that vitamin D supplements are beneficial in children and adolescents with normal vitamin D levels .
OBJECTIVE To determine the effectiveness of vitamin D supplementation for improving  bone mineral density in children and adolescents and if effects vary with factors such as vitamin D dose and vitamin D status .