A metaregression analysis indicated that , after adjusting for possible confounders , studies where fluoxetine was the experimental agent were positively associated with treatment effect , indicating a significant advantage for fluoxetine .
The evidence that the outcome of fluoxetine trials varied according to whether this drug was used as a new compound or a reference one suggests the presence of bias
The present study investigated whether the outcome of r and omized clinical trials study ing fluoxetine favored fluoxetine , where this was the experimental agent , and favored comparator antidepressants in trials where fluoxetine was the reference agent .
A comparison of fluoxetine imipramine and placebo in patients with bipolar depressive disorder.
This was a 6-week , double-blind comparison of fluoxetine , imipramine , and placebo in 89 patients with bipolar depression . Using the criteria of greater than or equal to 50 % improvement in the HAMD-total score after at least 3 weeks on study drug , endpoint analysis showed 86 % of the fluoxetine-treated patients improved compared with 57 % of the imipramine-treated and 38 % of the placebo-treated patients . Significantly fewer fluoxetine-treated patients discontinued due to adverse events than did imipramine-treated patients ( 7 % vs. 30 % , respectively )
A metaregression analysis indicated that , after adjusting for possible confounders , studies where fluoxetine was the experimental agent were positively associated with treatment effect , indicating a significant advantage for fluoxetine .
The evidence that the outcome of fluoxetine trials varied according to whether this drug was used as a new compound or a reference one suggests the presence of bias
The present study investigated whether the outcome of r and omized clinical trials study ing fluoxetine favored fluoxetine , where this was the experimental agent , and favored comparator antidepressants in trials where fluoxetine was the reference agent .