Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Pleiotropic effects of atorvastatin in heart failure: role in oxidative stress, inflammation, endothelial function, and exercise capacity.
BACKGROUND Increased oxidative stress , a common feature in chronic heart failure , has been associated with inflammation , endothelial dysfunction , and extracellular matrix degradation . Statins have known anti-inflammatory and anti-oxidant effects ; however , their role in chronic heart failure is still controversial . METHODS This was a prospect i ve study of 38 patients with stable systolic chronic heart failure . Patients received a 4-week placebo course , followed by atorvastatin 20 mg/day for 8 weeks .  Oxidative stress , inflammation and remodeling markers , brachial artery flow-mediated vasodilation , and 6-minute walk test were evaluated at baseline , 4 , and 8 weeks . RESULTS Mean age was 58 + /- 12 . Mean left ventricular ejection fraction was 27 % + /- 12 % . No significant differences were observed between measurements at baseline and after placebo . Atorvastatin induced a significant decrease of matrix metalloproteinase-9 activity , high-sensitivity C-reactive protein , tumor necrosis factor-alpha , interleukin-6 , and malondialdehyde , and a significant increase of endothelial superoxide dismutase activity when compared with placebo . No differences in tissue inhibitor of matrix metalloproteinase and matrix metalloproteinase-2 activities were observed . Atorvastatin use was associated with an improved flow-dependent brachial vasodilation and exercise capacity in the 6-minute walk test . CONCLUSIONS In chronic heart failure patients , atorvastatin therapy is associated with a decrease of inflammation and extracellular matrix remodeling , improving both endothelial function and exercise capacity
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .