The baseline characteristics related to lipid profile were more favorable for metabolically healthy obese than for metabolically unhealthy obese .
Changes in fasting glucose , HOMA-IR and hsCRP did not show significant changes .
Sufficient evidence was not found to support the use of specific diets in metabolically healthy obese subjects .
This analysis suggests that the effect of caloric restriction exerts its effects through a reduction in BMI , blood pressure and triglycerides in metabolically healthy obese ( MHO ) patients
The aim of this systematic review was to assess the effect of diet on changes in parameters describing the body size phenotype of metabolically healthy obese subjects .
Two Healthy Diets Modulate Gut Microbial Community Improving Insulin Sensitivity in a Human Obese Population.
CONTEXT Gut microbiota , which acts collectively as a fully integrated organ in the host metabolism , can be shaped by long-term dietary interventions after a specific diet . OBJECTIVE The aim was to study the changes in microbiota after 1 year 's consumption of a Mediterranean diet ( Med diet ) or a low-fat , high-complex carbohydrate diet ( LFHCC diet ) in an obese population . DESIGN Participants were r and omized to receive the Med diet ( 35 % fat , 22 % monounsaturated ) and the LFHCC diet ( 28 % fat , 12 % monounsaturated ) . SETTING AND PARTICIPANTS The study was conducted in 20 obese patients ( men ) within the Coronary Diet Intervention With Olive Oil and Cardiovascular Prevention ( CORDIOPREV ) study , an ongoing prospect i ve , r and omized , opened , controlled trial in patients with coronary heart disease . MAIN OUTCOME MEASURE We evaluated the bacterial composition and its relationship with the whole fecal and plasma metabolome . RESULTS The LFHCC diet increased the Prevotella and decreased the Roseburia genera , whereas the Med diet decreased the Prevotella and increased the Roseburia and Oscillospira genera ( P = .028 , .002 , and .016 , respectively ) . The abundance of Parabacteroides distasonis ( P = .025 ) and Faecalibacterium prausnitzii ( P = .020 ) increased after long-term consumption of the Med diet and the LFHCC diet , respectively . The changes in the abundance of 7 of 572 metabolites found in feces , including mainly amino acid , peptide , and sphingolipid metabolism , could be linked to the changes in the gut microbiota . CONCLUSIONS Our results suggest that long-term consumption of the Med and LFHCC diets exerts a protective effect on the development of type 2 diabetes by different specific changes in the gut microbiota , increasing the abundance of the Roseburia genus and F. prausnitzii , respectively
The baseline characteristics related to lipid profile were more favorable for metabolically healthy obese than for metabolically unhealthy obese .
Changes in fasting glucose , HOMA-IR and hsCRP did not show significant changes .
Sufficient evidence was not found to support the use of specific diets in metabolically healthy obese subjects .
This analysis suggests that the effect of caloric restriction exerts its effects through a reduction in BMI , blood pressure and triglycerides in metabolically healthy obese ( MHO ) patients
The aim of this systematic review was to assess the effect of diet on changes in parameters describing the body size phenotype of metabolically healthy obese subjects .