Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .
Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men
Background / Objectives : Dietary addition of either conjugated linoleic acid ( CLA ) or n-3 long-chain polyunsaturated fatty acids ( n-3 LC-PUFAs ) has been shown to alter adiposity and circulating lipids , risk markers of cardiovascular diseases . However , CLA may decrease insulin sensitivity , an effect that may be reversed by n-3 LC-PUFA . Thus , the potential of CLA plus n-3 LC-PUFA to affect insulin secretion and sensitivity in non-diabetic young and old , lean and obese subjects was tested . Subjects/ Methods : CLA ( 3 g daily ) plus n-3 LC-PUFA ( 3 g daily ) or control oil ( 6 g daily ) was given to lean ( n=12 ; BMI 20–26 kg/m2 ) or obese ( n=10 ; BMI 29–35 kg/m2 ) young ( 20–37 years old ) or lean ( n=16 ) or obese ( n=11 ) older men ( 50–65 years ) for 12 weeks . The study had a double-blind , placebo-controlled r and omized crossover design , and primary end points were insulin secretion and sensitivity during a st and ardized meal test , evaluated by modeling glucose , insulin and C-peptide data . Results : The combination was well tolerated . There was no significant difference in fasting levels of glucose , insulin or C-peptide after CLA/n-3 LC-PUFA treatment compared with control oil . Neither insulin secretion nor estimated sensitivity was affected by CLA/n-3 LC-PUFA in lean or obese young subjects or in older lean subjects . However , in older obese subjects , estimated insulin sensitivity was reduced with CLA/n-3 LC-PUFA compared with control ( P=0.024 ) . Conclusions : The results do not support beneficial effects of CLA/n-3 LC-PUFA for β-cell dysfunction or insulin resistance in humans but suggest that insulin sensitivity in older obese subjects is reduced
Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .