Subgroup analysis revealed that increasing dietary ALA tends to elevate CRP concentration  in healthy subjects .
However , the null effect of ALA supplementation on other inflammatory markers was not changed in various subgroups , indicating that the results are stable .
Meta-regression results revealed a negative relationship between the effect size on CRP and its baseline concentration .
No significant publication bias was observed for all inflammatory markers as suggested by funnel plot and Begg ’s test .
Conclusion Our meta- analysis did not find any beneficial effect of ALA supplementation  on reducing inflammatory markers including TNF , IL-6 , CRP , sICAM-1 , and sVCAM-1 .
However , in healthy subjects  , ALA supplementation might increase CRP concentration
Purpose The aim of the current meta- analysis was to investigate the effect of increasing dietary ALA intake on the blood concentration of inflammatory markers including tumor necrosis factor ( TNF ) , interleukin 6 ( IL-6 ) , C-reactive protein ( CRP ) , soluble intercellular adhesion molecule-1 ( sICAM-1 ) , and soluble vascular cell adhesion molecule-1 ( sVCAM-1 )  in adults .
Antihypertensive effect and safety of dietary alpha-linolenic acid in subjects with high-normal blood pressure and mild hypertension.
We investigated the antihypertensive effect and safety of alpha-linolenic acid ( ALA ) in human subjects . In Experiment 1 , subjects with high-normal blood pressure and mild hypertension ingested bread containing 14 g of common blended oil ( control oil ) or ALA-enriched oil for 12 weeks . The test oil contained 2.6g/14 g of ALA . The subjects ingested strictly controlled meals during the study period . Systolic blood pressure was significantly lower in the ALA group than in the control group after ingestion of the test diet for 4 , 8 and 12 weeks . Diastolic blood pressure was significantly lower in the ALA group than in the control group after ingestion of the test diet for 12 weeks . In Experiment 2 , we evaluated the safety of high intake of ALA ( 7.8 g/d ) , particularly its effects on oxidation in the body and blood coagulation .  Normotensive , high-normotensive and mildly hypertensive subjects ate bread that contained 42 g of the control oil or the test oil for 4 weeks . No significant difference was noted in the lipid peroxide level , high-sensitive C-reactive protein level , plasma prothrombin time or activated partial thromboplastin time between the two groups . No abnormal changes were noted after test diet ingestion on blood test or urinalysis , and no adverse event considered to have been induced by the test oil was observed in Experiment 1 and 2 . These results suggest that ALA have an antihypertensive effect with no adverse effect in subjects with high-normal blood pressure and mild hypertension
Subgroup analysis revealed that increasing dietary ALA tends to elevate CRP concentration  in healthy subjects .
However , the null effect of ALA supplementation on other inflammatory markers was not changed in various subgroups , indicating that the results are stable .
Meta-regression results revealed a negative relationship between the effect size on CRP and its baseline concentration .
No significant publication bias was observed for all inflammatory markers as suggested by funnel plot and Begg ’s test .
Conclusion Our meta- analysis did not find any beneficial effect of ALA supplementation  on reducing inflammatory markers including TNF , IL-6 , CRP , sICAM-1 , and sVCAM-1 .
However , in healthy subjects  , ALA supplementation might increase CRP concentration
Purpose The aim of the current meta- analysis was to investigate the effect of increasing dietary ALA intake on the blood concentration of inflammatory markers including tumor necrosis factor ( TNF ) , interleukin 6 ( IL-6 ) , C-reactive protein ( CRP ) , soluble intercellular adhesion molecule-1 ( sICAM-1 ) , and soluble vascular cell adhesion molecule-1 ( sVCAM-1 )  in adults .