Meta- analysis of BCG therapy showed improvement in symptoms according to the Wisconsin Interstitial Cystitis Symptom Inventory , but no difference in 24-h urinary frequency .
Conclusions Meta- analysis showed an improvement exclusively of the symptoms as measured by the Wisconsin Interstitial Cystitis Inventory , but not in 24-h urinary frequency , with BCG therapy .
Introduction and hypothesisThe objective of the study was to assess the effectiveness of intravesical treatment for painful bladder syndrome ( PBS ) .
The efficacy and safety of intravesical Bacillus-Calmette-Guerin in the treatment of female patients with interstitial cystitis: a double-blinded prospective placebo controlled study.
PURPOSE To evaluate the efficacy and safety of intravesical Bacillus Calmette-Gurein injection in the treatment of female patients with interstitial cystitis . MATERIAL S AND METHODS Thirty women meeting the National Institute of Arthritis , Diabetes , digestive and kidney diseases criteria for interstitial cystitis , were r and omized in a double-blinded fashion in two groups each consisted of 15 patients to receive six , weekly instillation of 120 mg BCG vaccine of Iranian Institute of pastor or placebo . Periodic question naires on symptoms of interstitial cystitis , voiding diaries , bladder capacity at first desire to void , and maximum bladder capacity were obtained . Adverse events were closely monitored during the treatment and follow-up phases of the study . Subjective and objective baseline values were compared with the follow-up data . RESULTS With a mean follow-up of 24 ( range 6 to 33 ) months 11 out of 15 ( 73 % ) in BCG group , and 3 out of 15 ( 20 % ) in placebo group responded to the treatment ( p<0.002 ) . Responders were defined the patients with more than 40 % improvement in the symptoms of interstitial cystitis . The global improvement in symptoms and signs of interstitial cystitis was 62 % . Adverse events were similar in both groups , mostly irritative in nature and no significant systemic event was noted . BCG did not worsen interstitial cystitis symptoms . CONCLUSION We concluded that intravesical BCG is safe , effective , available , and inexpensive with relatively durable results in the treatment of interstitial cystitis
Meta- analysis of BCG therapy showed improvement in symptoms according to the Wisconsin Interstitial Cystitis Symptom Inventory , but no difference in 24-h urinary frequency .
Conclusions Meta- analysis showed an improvement exclusively of the symptoms as measured by the Wisconsin Interstitial Cystitis Inventory , but not in 24-h urinary frequency , with BCG therapy .
Introduction and hypothesisThe objective of the study was to assess the effectiveness of intravesical treatment for painful bladder syndrome ( PBS ) .