The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .
Functional Vascular Study in Hypertensive Subjects with Type 2 Diabetes Using Losartan or Amlodipine
Background Antihypertensive drugs are used to control blood pressure ( BP ) and reduce macro- and microvascular complications in hypertensive patients with diabetes . Objectives The present study aim ed to compare the functional vascular changes in hypertensive patients with type 2 diabetes mellitus after 6 weeks of treatment with amlodipine or losartan . Methods Patients with a previous diagnosis of hypertension and type 2 diabetes mellitus were r and omly divided into 2 groups and evaluated after 6 weeks of treatment with amlodipine ( 5 mg/day ) or losartan ( 100 mg/day ) . Patient evaluation included BP measurement , ambulatory BP monitoring , and assessment of vascular parameters using applanation tonometry , pulse wave velocity ( PWV ) , and flow-mediated dilation ( FMD ) of the brachial artery . Results A total of 42 patients were evaluated ( 21 in each group ) , with a predominance of women ( 71 % ) in both groups . The mean age of the patients in both groups was similar ( amlodipine group : 54.9 ± 4.5 years ; losartan group : 54.0 ± 6.9 years ) , with no significant difference in the mean BP  [ amlodipine group : 145 ± 14 mmHg ( systolic ) and 84 ± 8 mmHg ( diastolic ) ; losartan group : 153 ± 19 mmHg ( systolic ) and 90 ± 9 mmHg ( diastolic ) ] . The augmentation index ( 30 % ± 9 % and 36 % ± 8 % , p = 0.025 ) and augmentation pressure ( 16 ± 6 mmHg and 20 ± 8 mmHg , p = 0.045 ) were lower in the amlodipine group when compared with the losartan group . PWV and FMD were similar in both groups . Conclusions Hypertensive patients with type 2 diabetes mellitus treated with amlodipine exhibited an improved pattern of pulse wave reflection in comparison with those treated with losartan . However , the use of losartan may be associated with independent vascular reactivity to the pressor effect
The effect of ARB on the improvement of the PWV level is not superior to other types of antihypertensive agents , but ARB is superior to other types of antihypertensive agents for improving the AI level .
Overall , to improve of arterial stiffness , ARB maybe is superior to other antihypertensive agents
BACKGROUND This system review and meta- analysis was conducted to systematic ally review and analyze the clinical benefits of different antihypertensive agents in improving arterial stiffness in hypertensive patients .