However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .
Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults.
BACKGROUND Blood lipids and inflammatory markers levels have been associated with the development and progression of atherosclerosis . As the association of inflammatory markers with plasma fatty acids has not been extensively evaluated and understood , we sought to investigate the associations between dietary and plasma fatty acids with various inflammation and coagulation markers . METHODS High sensitivity C-reactive protein ( hsCRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-alpha ( TNF-alpha ) , fibrinogen , and homocysteine were measured in serum of 374 free-living , healthy men and women , r and omly selected from the ATTICA 's study data base .  Total plasma fatty acids  were determined by gas chromatography . Dietary fatty acids  were assessed through a semi-quantitative FFQ . RESULTS Multi-adjusted regression analyses revealed that plasma n-3 fatty acids were inversely associated with CRP , IL-6 and TNF-alpha ; plasma n-6 fatty acids were inversely associated with CRP , IL-6 and fibrinogen ; monounsaturated fatty acids were inversely associated with CRP and IL-6 ( all p-values<0.05 ) . Interestingly , the n-6/n-3 ratios exhibited the strongest positive correlations with all the markers studied . No associations were observed between dietary fatty acids and the investigated markers . CONCLUSIONS Measurements of total plasma fatty acids could provide insights into the relationships between diet and atherosclerotic disease . Moreover , the n-6/n-3 ratio may constitute a predictor of low- grade inflammation and coagulation
However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .