Comparison of PO diets with diets rich in stearic acid , monounsaturated fatty acids ( MUFAs ) , and polyunsaturated fatty acids ( PUFAs ) showed significantly higher TC , LDL cholesterol , apolipoprotein B , HDL cholesterol , and apolipoprotein A-I , whereas most of the same biomarkers were significantly lower when compared with diets rich in myristic/lauric acid .
Comparison of PO-rich diets with diets rich in trans fatty acids showed significantly higher concentrations of HDL cholesterol and apolipoprotein A-I and significantly lower apolipoprotein B , triacylglycerols , and TC/HDL cholesterol .
Stratified and meta-regression analyses showed that the higher concentrations of TC and LDL cholesterol , when PO was substituted for MUFAs and PUFAs , were not significant in young people and in subjects with diets with a lower percentage of energy from fat .
Both favorable and unfavorable changes in CHD/CVD risk markers occurred when PO was substituted for the primary dietary fats , whereas only favorable changes occurred when PO was substituted for trans fatty acids .
BACKGROUND Palm oil ( PO ) may be an unhealthy fat because of its high saturated fatty acid content .
OBJECTIVE The objective was to assess the effect of substituting PO for other primary dietary fats on blood lipid-related markers of coronary heart disease ( CHD ) and cardiovascular disease ( CVD ) .
Short-term diets enriched in stearic or palmitic acids do not alter plasma lipids, platelet aggregation or platelet activation status
Objective : To determine whether healthy males who consumed increased amounts of dietary stearic acid compared with increased dietary palmitic acid through the consumption of commercially available foods , exhibited any changes in plasma lipids , platelet aggregation or platelet activation status . Design : A r and omised cross-over dietary intervention . Subjects and interventions : Nine free-living healthy males consumed two experimental diets ( stearic acid enriched , diet S , and palmitic acid enriched , diet P ) for 3 weeks in a r and omised cross-over design separated by a 3 week washout phase . The diets consisted of ∼30 % of energy as fat ( 30 % of which was derived from the treatment diets ) providing ∼13 g/day as stearic acid and 17 g/day as palmitic acid on diet S and ∼7 g/day as stearic acid and 22 g/day as palmitic acid on diet P. The dietary ratio of stearic to palmitic acids was 0.76 on diet S compared with 0.31 on diet P. Blood sample s were collected on days 0 and 21 of each dietary period . Results : LDL cholesterol levels and platelet aggregation response to the agonist ADP were significantly decreased ( P<0.025 ) in subjects on diet S compared with day 0 . Apart from that , there were no significant changes in plasma lipids , platelet aggregation , mean platelet volume and platelet reactivity between diets . There were no significant changes in stearic or palmitic acid levels in plasma phospholipid or triacylglycerol . There was a significant difference in palmitic acid levels in platelet phospholipids between the two diets . Conclusions : Use of commonly available foods led to a 27 % increase in stearic acid ( diet S ) and a 19 % increase in palmitic acid ( diet P ) , on diets S and P respectively , and no significant differences between the two diets in plasma lipoprotein concentrations , platelet aggregation or platelet activation status . Sponsorship : Grant and chocolate donated from Effem Foods , Pty Ltd , Australia
Comparison of PO diets with diets rich in stearic acid , monounsaturated fatty acids ( MUFAs ) , and polyunsaturated fatty acids ( PUFAs ) showed significantly higher TC , LDL cholesterol , apolipoprotein B , HDL cholesterol , and apolipoprotein A-I , whereas most of the same biomarkers were significantly lower when compared with diets rich in myristic/lauric acid .
Comparison of PO-rich diets with diets rich in trans fatty acids showed significantly higher concentrations of HDL cholesterol and apolipoprotein A-I and significantly lower apolipoprotein B , triacylglycerols , and TC/HDL cholesterol .
Stratified and meta-regression analyses showed that the higher concentrations of TC and LDL cholesterol , when PO was substituted for MUFAs and PUFAs , were not significant in young people and in subjects with diets with a lower percentage of energy from fat .
Both favorable and unfavorable changes in CHD/CVD risk markers occurred when PO was substituted for the primary dietary fats , whereas only favorable changes occurred when PO was substituted for trans fatty acids .
BACKGROUND Palm oil ( PO ) may be an unhealthy fat because of its high saturated fatty acid content .
OBJECTIVE The objective was to assess the effect of substituting PO for other primary dietary fats on blood lipid-related markers of coronary heart disease ( CHD ) and cardiovascular disease ( CVD ) .