Based on the available evidence , motor evoked potentials at rest were the only biomarker that predicted motor outcome in individuals with severe arm impairment following stroke .
To build an underst and ing of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke , we conducted a pooled individual data systematic review to : 1 ) characterize brain biomarkers ; 2 ) determine relationship(s ) between biomarkers and motor outcome ; and 3 ) establish relationship(s ) between biomarkers and motor recovery .
Corticospinal integrity and motor impairment predict outcomes after excitatory repetitive transcranial magnetic stimulation: a preliminary study.
OBJECTIVE To identify the effective predictors for therapeutic outcomes based on intermittent theta-burst stimulation ( iTBS ) . DESIGN A sham-controlled , double-blind parallel study design . SETTING A tertiary hospital . PARTICIPANTS People with stroke ( N=72 ) who presented with unilateral hemiplegia . INTERVENTIONS Ten consecutive sessions of real or sham iTBS were implemented with the aim of enhancing h and function . Patients were categorized into 4 groups according to the presence ( MEP+ ) or absence ( MEP- ) of motor-evoked potentials ( MEPs ) and grip strength according to the Medical Research Council ( MRC ) scale . MAIN OUTCOME MEASURES Cortical excitability , Wolf Motor Function Test ( WMFT ) , finger-tapping task ( FT ) , and simple reaction time were performed before and after the sessions . RESULTS MEPs and the MRC scale were predictive of iTBS therapeutic outcomes . Group A ( MEP+ , MRC>1 ) exhibited the greatest WMFT change ( 7.6±2.3 , P<.001 ) , followed by group B ( MEP- , MRC>1 ; 5.2±2.2 score change ) and group C ( MEP- , MRC=0 ; 2.3±1.5 score change ) . These improvements were correlated significantly with baseline motor function and ipsilesional maximum MEP amplitude . CONCLUSIONS The effectiveness of iTBS modulation for poststroke motor enhancement depends on baseline h and grip strength and the presence of MEPs . Our findings indicate that establishing neurostimulation strategies based on the proposed electrophysiological and clinical criteria can allow iTBS to be executed with substantial precision . Effective neuromodulatory strategies can be formulated by using electrophysiological features and clinical presentation information as guidelines
Based on the available evidence , motor evoked potentials at rest were the only biomarker that predicted motor outcome in individuals with severe arm impairment following stroke .
To build an underst and ing of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke , we conducted a pooled individual data systematic review to : 1 ) characterize brain biomarkers ; 2 ) determine relationship(s ) between biomarkers and motor outcome ; and 3 ) establish relationship(s ) between biomarkers and motor recovery .