This review suggests that both benzodiazepines work , but that midazolam has a faster onset and thereby reduces the risk of exposure to violence .
Most evidence , however , exists for the haloperidol plus promethazine mix , with currently more than 400 people r and omised to the combination .
The onset of action is swift and faster than lorazepam .
The combination also seems safe with no clear longer term consequences .
BACKGROUND Health services often manage agitated or violent people and for emergency psychiatric services such behaviour is particularly prevalent ( 10 % ) .
The drugs used in this situation should ensure that the person swiftly and safely becomes calm .
OBJECTIVES To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression .
A pilot study of the role of prophylactic antiparkinson treatment during neuroleptic therapy.
The authors administered haloperidol 4.5 mg t.i.d . to 33 drug-free schizophrenic patients . Ten patients did not receive anything else ( group HPL ) , while ten patients received procyclidine 5 mg t.i.d . , and 13 patients were given promethazine 25 mg t.i.d . ( groups HPRC and HPRM respectively ) in addition . Seven patients dropped out of the HPL group and three out of the HPRM group , but none out of the HPRC group . These drop outs were due to the development of early extrapyramidal side effects , which were absent in the HPRC group . The findings suggest that antiparkinson prophylaxis is useful during commencement of therapy with high-potency neuroleptic agents
This review suggests that both benzodiazepines work , but that midazolam has a faster onset and thereby reduces the risk of exposure to violence .
Most evidence , however , exists for the haloperidol plus promethazine mix , with currently more than 400 people r and omised to the combination .
The onset of action is swift and faster than lorazepam .
The combination also seems safe with no clear longer term consequences .
BACKGROUND Health services often manage agitated or violent people and for emergency psychiatric services such behaviour is particularly prevalent ( 10 % ) .
The drugs used in this situation should ensure that the person swiftly and safely becomes calm .
OBJECTIVES To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression .