This meta- analysis concludes that l-arginine supplementation can significantly reduce blood TAG levels ; however , there is insufficient evidence to support its hypocholesterolaemic effects .
A number of clinical trials have examined the effect of l-arginine on lipid profile in recent years ; however , the results remain equivocal .
Therefore , the present study aims to summarise and quantitatively examine the available evidence on the effectiveness l-arginine supplementation on lipid parameters using a systematic review and meta-analytic approach .
Effect of oral supplementation of free amino acids in type 2 diabetic patients-- a pilot clinical trial.
BACKGROUND Oral amino acid intake reduces plasma glucose in Streptozotocin-induced diabetic rats . This study examined the effect of oral amino acid supplementation in patients with type 2 diabetes mellitus ( DM ) . MATERIAL / METHODS A double blind pilot clinical trial was conducted for a period of 2 months on 77 subjects with type 2 DM . Subjects of both sexes , ages 30 - 60 , were included in the trial . All were receiving oral antidiabetic tablets . They were divided into groups on the basis of oral supplementation : ( A ) lysine , ( B ) essential amino acids , ( C ) amino acids and vitamins ( fat and water-soluble ) , and ( D ) calcium phosphate ( control ) . The subjects were periodically examined for fasting and post-pr and ial plasma glucose , fasting and post-pr and ial immunoreactive insulin , plasma amino acids , glycosylated haemoglobin ( HbA1c ) , proteins and albumin in serum , urea and creatinine in plasma and sugar , and proteins and ketones in urine . RESULTS The results revealed a significant decrease in PP plasma glucose ( P<0.05 ) in group B when compared to groups C and D after 45 days . Plasma Arginine was increased in group C from 3.84 to 9.24 mg/dl . There were no statistically significant changes seen in other parameters between groups and visits . CONCLUSIONS Oral supplementation with amino acids for patients with type 2 DM appears to decrease PP plasma glucose without any change in plasma insulin levels , perhaps due to improved insulin sensitivity . However , the long term effects of amino acids need further study
This meta- analysis concludes that l-arginine supplementation can significantly reduce blood TAG levels ; however , there is insufficient evidence to support its hypocholesterolaemic effects .
A number of clinical trials have examined the effect of l-arginine on lipid profile in recent years ; however , the results remain equivocal .
Therefore , the present study aims to summarise and quantitatively examine the available evidence on the effectiveness l-arginine supplementation on lipid parameters using a systematic review and meta-analytic approach .