A greater reduction in BMI was found with multiple species of probiotics .
Consuming probiotics  could reduce body weight and BMI , with a potentially greater effect when multiple species of probiotics were consumed , the duration of intervention was ≥8 weeks , or the objects were overweight
OBJECTIVE To assess the efficacy of probiotic therapies on body weight and BMI  using a meta- analysis of r and omized , controlled trials .
Lactobacillus acidophilus La5, Bifidobacterium BB12, and Lactobacillus casei DN001 modulate gene expression of subset specific transcription factors and cytokines in peripheral blood mononuclear cells of obese and overweight people.
Probiotics are believed to have interaction with immune cells through sustained effects on gene expression of different cytokines and transcription factors . The present r and omized doubled-blind controlled clinical trial was performed recruiting 75 individuals with BMI 25 - 35 , who were r and omly assigned to the following three groups : Group 1 ( n = 25 ) who consumed regular yogurt as part of a low calorie diet [ RLCD ] , group 2 ( n = 25 ) who received probiotic yogurt with a LCD [ PLCD ] and group 3 ( n = 25 ) who consumed probiotic yogurt without LCD [ PWLCD ] for 8 week . Participants in PLCD and PWLCD groups received 200 g/day yogurt containing Lactobacillus acidophilus La5 , Bifidobacterium Bb12 , and lactobacillus casei DN001 10(8 ) cfu/gr . The expression of the FOXP3 , T-bet , GATA3 , TNF-α , IFN-γ , TGF-β , and ROR-γt in P BMC s genes were assessed , before and after intervention . In three groups , ROR-γt expression was reduced ( P = 0.007 ) and FOXP3 was increased ( P < 0.001 ) . The expression of TNFα , TGFβ , and GATA3 genes did not change among all groups after intervention . Interestingly , the expression of T-bet gene , which was significantly decreased in PLCD and PWLCD groups ( P < 0.001 ) , whereas gene expression of IFN-γ decreased in all three groups . Our results suggest that weight loss diet and probiotic yogurt had synergistic effects on T-cell subset specific gene expression in peripheral blood mononuclear cells among overweight and obese individuals
A greater reduction in BMI was found with multiple species of probiotics .
Consuming probiotics  could reduce body weight and BMI , with a potentially greater effect when multiple species of probiotics were consumed , the duration of intervention was ≥8 weeks , or the objects were overweight
OBJECTIVE To assess the efficacy of probiotic therapies on body weight and BMI  using a meta- analysis of r and omized , controlled trials .