CLINICAL IMPLICATION S Only SCORAD , EASI , and POEM currently perform adequately .
BACKGROUND Valid and reliable outcome measurements are a prerequisite for evidence -based practice .
The comparative validity and reliability of outcome measurements for assessing atopic eczema ( AE ) severity is unclear .
OBJECTIVE We sought to assess the validity , reliability , sensitivity to change , and ease of use of outcome measurements for AE .
We also sought to give recommendations on which outcomes to use in clinical research and for clinical monitoring .
Correlation of eosinophils, eosinophil cationic protein and soluble interleukin-2 receptor with the clinical activity of atopic dermatitis.
To evaluate the correlation with the clinical activity of atopic dermatitis ( AD ) we investigated prospect ively cellular and serological parameters such as eosinophils , eosinophil cationic protein ( ECP ) , soluble IL-2 receptor ( sIL-2R ) , soluble CD23 ( sCD23 ) and lactate dehydrogenase ( LDH ) in peripheral blood of 37 AD patients on admission to and discharge from the Department of Dermatology at the University Hospital in Zurich . On admission the actual clinical skin condition as measured by the skin intensity score ( SIS ) was significantly correlated with eosinophils ( p less than 0.005 ) , ECP ( p less than 0.05 ) and sIL-2R ( p less than 0.001 ) . During the observation period a significant improvement in the clinical status as measured by the SIS was observed in all AD patients ( p less than 0.001 ) . A significant decrease in sIL-2R ( p less than 0.005 ) , which was most pronounced in the group of AD patients receiving systemic steroids , together with a decrease in eosinophils and ECP but not in sCD23 and LDH could be demonstrated between admission and discharge . In addition , a slight but significant increase in peripheral blood lymphocytes ( p less than 0.005 ) and monocytes ( p less than 0.01 ) was noted . Comparing the ' extrinsic ' ( n = 32 ) and the ' intrinsic ' ( n = 5 ) types of AD no significant differences with regard to the above mentioned parameters were found . Our data indicate that cellular and serological parameters such as eosinophils , ECP and sIL-2R reflect the clinical activity of AD and may therefore give further insights into the pathogenesis of this disease
CLINICAL IMPLICATION S Only SCORAD , EASI , and POEM currently perform adequately .
BACKGROUND Valid and reliable outcome measurements are a prerequisite for evidence -based practice .
The comparative validity and reliability of outcome measurements for assessing atopic eczema ( AE ) severity is unclear .
OBJECTIVE We sought to assess the validity , reliability , sensitivity to change , and ease of use of outcome measurements for AE .
We also sought to give recommendations on which outcomes to use in clinical research and for clinical monitoring .