A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?
Exercise, sleep quality, and mediators of sleep in breast and prostate cancer patients receiving radiation therapy.
Cancer patients often report impaired sleep quality . Impaired sleep quality may be due to increased levels of sleep-mediating cytokines result ing from cancer treatment . Exercise may have a positive influence on sleep-mediating cytokines , such as interleukin-6 ( IL-6 ) , tumor necrosis factor-alpha ( TNF-α ) , and soluble tumor necrosis factor-alpha receptor ( sTNF-R ) , which may improve sleep quality . This two-arm pilot study compared the influence of a home-based exercise intervention with st and ard care/control on sleep quality and mediators of sleep . Breast and prostate cancer patients ( n = 38 ) beginning radiation therapy were r and omized to a 4-week exercise program or no exercise arm . Global sleep quality , subjective sleep quality , sleep latency , sleep duration , sleep efficiency , sleep disturbances , use of sleep medication , and daytime dysfunction were assessed with the Pittsburgh Sleep Quality Index . IL-6 , TNF-α , and sTNF-R were measured before and after intervention . There was a greater improvement in sleep quality in the exercise  group from pre- to postintervention , although the difference was not significant . Additionally , there were associations between IL-6 and sleep efficiency and duration , suggesting that regulation of sleep-mediating cytokines by exercise may mediate improvements in sleep- quality components
A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?