This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .
Postoperative recovery after cholecystectomy by minilaparotomy: a randomized double-blind comparison between alpha-trinositol and placebo.
An opioid-sparing effect of alpha-trinositol ( D-myo-inositol 1,2,6-trisphosphate ) following cholecystectomy in otherwise healthy patients was suggested by a pilot study . In order to verify this result , pain , pain relief and nausea were studied in patients undergoing elective cholecystectomy by minilaparotomy .  The patients were r and omized using double-blind design to receive an intravenous infusion of either alpha-trinositol or sodium chloride ( placebo ) for eight hr after the operation . Pain , pain relief and nausea were evaluated up to 72 hr after surgery using visual analogue scales ( VAS ) . Rescue analgesic medication was registered . As a further measure of pain and /or restrictions caused by pain , peak expiratory flow , walking distance and pressure pain thresholds were assessed . There was no difference between the groups in ratings of pain , pain relief , nausea or amount of analgesic medication given . The mean ratings of pain were significantly higher in the sitting position compared to lying down . Neither pressure pain thresholds , nor the walking distance differed between the patients given alpha-trinositol and placebo , respectively . There were significant reductions of peak expiratory flow and of pressure pain thresholds under both costal margins up to 72 hr after surgery compared to presurgery values . As a conclusion , no analgesic effect of alpha-trinositol at the dosage used was observed in the postoperative patients studied
This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .