The majority of in vivo studies showed a null or inverse association of ghrelin with risk and progression of most cancers , suggesting that ghrelin/ghrelin-receptor agonist treatment may have a favorable safety profile to use for cancer cachexia .
Ghrelin is a hormone with multiple physiologic functions , including promotion of growth hormone release , stimulation of appetite and regulation of energy homeostasis .
Treatment with ghrelin/ghrelin-receptor agonists is a prospect i ve therapy for disease-related cachexia and malnutrition .
In vitro studies have shown high expression of ghrelin in cancer tissue , although its role including its impact in cancer risk and progression has not been established .
Ghrelin strongly stimulates growth hormone release in humans.
Ghrelin is a recently identified endogenous lig and for the GH secretagogue receptor and is involved in a novel system for regulating GH release . However , little is known about its GH-releasing activity and other endocrine effects in humans . To address this issue , we studied the GH , ACTH , cortisol , PRL , LH , FSH , and TSH responses to synthetic human ghrelin . In four normal male adults ( 28 - 37 yr ) , iv ghrelin administration released GH in a dose-dependent manner and 0.2 , 1.0 , and 5.0 microg/kg ghrelin produced 43.3 + /- 6.0 , 81.5 + /- 12.7 , and 107.0 + /- 10.7 ng/mL of the GH peak values at 30 min , respectively . ACTH , cortisol , and PRL levels were also elevated after ghrelin injection , while the lowest dose ( 0.2 microg/kg ) result ed in only minimum peak values of these hormones ( 22.8 + /- 3.0 pg/mL , 9.4 + /- 1.9 microg/dL , and 4.6 + /- 0.6 ng/mL , respectively ) . There were no significant changes in LH , FSH , or TSH levels . This is the first study showing evidence that ghrelin strongly stimulates GH release in humans
The majority of in vivo studies showed a null or inverse association of ghrelin with risk and progression of most cancers , suggesting that ghrelin/ghrelin-receptor agonist treatment may have a favorable safety profile to use for cancer cachexia .
Ghrelin is a hormone with multiple physiologic functions , including promotion of growth hormone release , stimulation of appetite and regulation of energy homeostasis .
Treatment with ghrelin/ghrelin-receptor agonists is a prospect i ve therapy for disease-related cachexia and malnutrition .
In vitro studies have shown high expression of ghrelin in cancer tissue , although its role including its impact in cancer risk and progression has not been established .