These studies demonstrated improvement in biochemical profiles , with a decline in or normalization of liver enzymes .
However , some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis .
There has been a growing interest in the role of vitamin E supplementation in the treatment and /or prevention of nonalcoholic fatty liver ( NAFLD ) .
Furthermore , histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only .
Zinc and Selenium Co-supplementation Reduces Some Lipid Peroxidation and Angiogenesis Markers in a Rat Model of NAFLD-Fed High Fat Diet
Studies have shown that non-alcoholic fatty liver disease ( NAFLD ) patients are more prone to cardiovascular disease ( CVD ) . Zinc and selenium deficiency are common in NAFLD . But the effects of zinc and selenium co-supplementation before and /or after disease progression on CVD markers are not clear in NAFLD patients . This study aim ed to compare the effects of zinc and selenium co-supplementation before and /or after disease progression on some of the CVD markers in an experimental model of NAFLD . Forty male Sprague Dawley rats ( 197 ± 4 g ) were r and omly assigned into four dietary groups : control group ( C ; received 9 % of calorie as fat ) , model group ( M ; received 82 % of calorie as fat ) , and supplementation before ( BS ) or after ( AS ) disease progression . Animals were fed diets for 20 weeks in all groups . Fasting plasma glucose ( FPG ) , insulin , HOMA-IR , ALT , AST , lipid profile , malondialdehyde ( MDA ) and vascular endothelial growth factor ( VEGF ) levels were measured as CVD indices . Serum ALT , AST , FPG , insulin , MDA , VEGF and HOMA-IR were significantly higher in the M than C group . Co-supplementation reduced serum ALT and AST levels in the BS and AS groups compared with the M group . FPG , insulin , HOMA-IR , VEGF , MDA , LDL/HDL-c and TC/HDL-c ratio were significantly reduced in the AS compared with the M group . TG/HDL-c ratio was significantly reduced in the BS and AS compared with the M group . Serum MDA , VEGF , Insulin and HOMA-IR were significantly lowered in the AS than BS group ( p < 0.05 ) . Zinc and selenium co-supplementation after NAFLD progression reduced CVD risk indices in an experimental model
These studies demonstrated improvement in biochemical profiles , with a decline in or normalization of liver enzymes .
However , some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis .
There has been a growing interest in the role of vitamin E supplementation in the treatment and /or prevention of nonalcoholic fatty liver ( NAFLD ) .
Furthermore , histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only .