The antihypertensive efficacy of HCTZ in its daily dose of 12.5 to 25 mg as measured in head-to-head studies by ambulatory BP measurement is consistently inferior to that of all other drug classes .
Because outcome data at this dose are lacking , HCTZ is an inappropriate first-line drug for the treatment of hypertension
OBJECTIVES The purpose of this study was to evaluate the antihypertensive efficacy of hydrochlorothiazide ( HCTZ ) by ambulatory blood pressure ( BP ) monitoring .
BACKGROUND HCTZ is the most commonly prescribed antihypertensive drug worldwide .
More than 97 % of all HCTZ prescriptions are for 12.5 to 25 mg per day .
The antihypertensive efficacy of HCTZ by ambulatory BP monitoring is less well defined .
Freehand three-dimensional echocardiographic evaluation of the effect of telmisartan compared with hydrochlorothiazide on left ventricular mass in hypertensive patients with mild-to-moderate hypertension: a multicentre study
Antihypertensive efficacy , effects on left ventricular mass index ( LVMI ) and tolerability of telmisartan , an angiotensin II receptor blocker , were compared with those of hydrochlorothiazide ( HCTZ ) .  Adult patients with mild-to-moderate hypertension and an optimal acoustic window by two-dimensional echocardiography were r and omised at baseline to 12 months ' double-blind , once-daily treatment with telmisartan 80 mg or HCTZ 25 mg . Two-dimensional echocardiography and freeh and precordial three-dimensional echocardiography and 24-h ambulatory blood pressure monitoring were performed at baseline and after treatment . Of the 41 telmisartan group patients and 28 HCTZ group patients , 40 and 25 , respectively , completed the study . Following treatment , 24-h mean SBP  ( telmisartan 157 ± 11 vs 133 ± 7 mmHg , P<0.001 ; HCTZ 154 ± 10 vs 144 ± 11 mmHg , P<0.003 ) and DBP  ( telmisartan 96 ± 6 vs 83 ± 5 mmHg , P<0.001 ; HCTZ 95 ± 7 vs 87 ± 8 mmHg , P<0.003 ) were significantly reduced . Telmisartan produced significantly greater 24-h mean SBP and DBP reductions than HCTZ ( P<0.001 ) . LVMI was significantly reduced by telmisartan ( 141 ± 16 vs 125 ± 19 g/m2 , P<0.001 ) , but not by HCTZ ( 139 ± 20 vs 135 ± 22 g/m2 ) . Incidences of adverse events in both the treatment groups were low ; two cases of hypokalaemia  occurred with HCTZ . In conclusion , telmisartan 80 mg was well tolerated and significantly reduced SBP , DBP and LVMI after 12 months ' treatment compared with HCTZ
The antihypertensive efficacy of HCTZ in its daily dose of 12.5 to 25 mg as measured in head-to-head studies by ambulatory BP measurement is consistently inferior to that of all other drug classes .
Because outcome data at this dose are lacking , HCTZ is an inappropriate first-line drug for the treatment of hypertension
OBJECTIVES The purpose of this study was to evaluate the antihypertensive efficacy of hydrochlorothiazide ( HCTZ ) by ambulatory blood pressure ( BP ) monitoring .
BACKGROUND HCTZ is the most commonly prescribed antihypertensive drug worldwide .
More than 97 % of all HCTZ prescriptions are for 12.5 to 25 mg per day .
The antihypertensive efficacy of HCTZ by ambulatory BP monitoring is less well defined .