We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
The Canadian asthma primary prevention study: outcomes at 2 years of age.
BACKGROUND Avoidance of individual risk factors have not been successful in preventing the development of asthma . OBJECTIVE We sought to determine the effectiveness of a multifaceted intervention program in primary prevention of asthma in high-risk infants . METHODS We identified 545 high-risk infants on the basis of an immediate family history of asthma . Families were r and omized into intervention or control groups . Intervention measures included avoidance of house dust mite , pet allergen , and environmental tobacco smoke . Breast-feeding was encouraged with formula supplementation if necessary , and introduction of solid foods was delayed . RESULTS At 2 years of age , 19.5 % of the children had asthma , and 14.7 % had atopy ( positive skin test response to one or more common allergens ) . Significantly fewer children had asthma in the intervention group compared with in the control group ( 16.3 % vs 23.0 % ) , with 60 % less persistent asthma at 2 years . There was a 90 % reduction for recurrent wheeze in the intervention group compared with that seen in the control group . Exposure to maternal environmental tobacco smoke during pregnancy or the first year was a risk factor for asthma at 2 years of age . A positive skin test response , particularly to food , at 12 months predicted asthma at 2 years . There was no significant difference for atopy between the intervention and control groups , but daycare reduced atopy at 2 years . CONCLUSION This multifaceted intervention program during a window of opportunity in the first year of life was effective in preventing  asthma  in high-risk children at 2 years of age . Future studies with this cohort at school age are important
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .