ConclusionS -carboxymethylcysteine is effective in the treatment of children with glue ear .
Objective To establish the clinical relevance of S-carboxymethylcysteine in the treatment of glue ear in children using measures approximating those saving a child from operation for grommet insertion .
Clinical evaluation of S-CMC syrup applied in the treatment of otitis media with effusion. Double blind comparative test with placebo.
We carried out a double blind comparative trial with placebo serving as control using 250 cases of infant otitis media with effusion ( OME ) in order to objective ly evaluate the clinical usefulness of S-carboxymethylcysteine ( S-CMC ) , an oral mucolytic agent , against OME . The results obtained were as follows . 1 ) Global improvement rate , when judged in items of overall improvement , was 79.8 % in S-CMC group and 58.2 % in placebo group , S group being significantly better when compared to P. 2 ) The degree of improvement in each item for evaluation revealed significantly better results in S group compared to P , in both objective findings of the effusion amount and its property , and in audiological findings . 3 ) Adverse reactions observed in 3 cases ( 2.5 % ) in S group and in 2 ( 1.5 % ) in P group were not serious , and were eliminated through suspension or discontinuation of the medication . The results obtained suggested the usefulness of S-CMC when used in the treatment of OME
ConclusionS -carboxymethylcysteine is effective in the treatment of children with glue ear .
Objective To establish the clinical relevance of S-carboxymethylcysteine in the treatment of glue ear in children using measures approximating those saving a child from operation for grommet insertion .