OC could significantly reduce the occurrence of VAP , and consequently , its routine use should be considered for VLBWs to prevent infectious diseases .
OC  significantly reduces the occurrence of VAP and NEC in VLBW infants  .
OC may reduce the incidence of VAP and NEC by increasing IgA levels .
Early OC therapy for mechanical ventilation of low-weight infants may prevent the occurrence of VAP .
OC significantly reduces the occurrence of VAP and NEC in VLBW infants .
OC may reduce the incidence of VAP and NEC by increasing IgA levels .
Early OC therapy for mechanical ventilation of low-weight infants may prevent the occurrence of VAP
Oropharyngeal colostrum ( OC ) is a novel feeding strategy to prevent complications of prematurity .
A meta- analysis was conducted to investigate whether very low birth weight infants ( VLBWs ) can benefit from OC .
Effect of probiotics on the incidence of ventilator-associated pneumonia in critically ill patients: a randomized controlled multicenter trial
Purpose To evaluate the potential preventive effect of probiotics on  ventilator-associated pneumonia ( VAP ) . Methods This was an open-label , r and omized , controlled multicenter trial involving 235 critically ill adult patients who were expected to receive mechanical ventilation for ≥48 h. The patients were r and omized to receive ( 1 ) a probiotics capsule containing live Bacillus subtilis and Enterococcus faecalis ( Medilac-S ) 0.5 g three times daily through a nasogastric feeding tube plus st and ard preventive strategies or ( 2 ) st and ard preventive strategies alone , for a maximum of 14 days . The development of VAP was evaluated daily , and throat swabs and gastric aspirate were cultured at baseline and once or twice weekly thereafter . Results The incidence of microbiologically confirmed VAP in the probiotics group was significantly lower than that in the control patients ( 36.4 vs. 50.4 % , respectively ; P = 0.031 ) . The mean time to develop VAP was significantly longer in the probiotics group than in the control group ( 10.4 vs. 7.5 days , respectively ; P = 0.022 ) . The proportion of patients with acquisition of gastric colonization of potentially pathogenic microorganisms ( PPMOs ) was lower in the probiotics group ( 24 % ) than the control group ( 44 % ) ( P = 0.004 ) . However , the proportion of patients with eradication PPMO colonization on both sites of the oropharynx and stomach were not significantly different between the two groups . The administration of probiotics did not result in any improvement in the incidence of clinical ly suspected VAP , antimicrobial consumption , duration of mechanical ventilation , mortality and length of hospital stay . Conclusion Therapy with the probiotic bacteria B. Subtilis and E. faecalis are an effective and safe means for preventing VAP and the acquisition of PPMO colonization in the stomach
OC could significantly reduce the occurrence of VAP , and consequently , its routine use should be considered for VLBWs to prevent infectious diseases .
OC  significantly reduces the occurrence of VAP and NEC in VLBW infants  .
OC may reduce the incidence of VAP and NEC by increasing IgA levels .
Early OC therapy for mechanical ventilation of low-weight infants may prevent the occurrence of VAP .
OC significantly reduces the occurrence of VAP and NEC in VLBW infants .
OC may reduce the incidence of VAP and NEC by increasing IgA levels .
Early OC therapy for mechanical ventilation of low-weight infants may prevent the occurrence of VAP
Oropharyngeal colostrum ( OC ) is a novel feeding strategy to prevent complications of prematurity .
A meta- analysis was conducted to investigate whether very low birth weight infants ( VLBWs ) can benefit from OC .