The meta- analysis showed a significant increase in plasma adiponectin levels following statin therapy .
Although statins are known to increase the risk for new onset diabetes mellitus , our data might suggest that the mechanism for this is unlikely to be due to a reduction in adiponectin expression
BACKGROUND AND AIMS The effect of statin therapy on plasma adiponectin levels has not been conclusively studied .
Therefore , we aim ed to evaluate this effect through a systematic review and meta- analysis of available r and omized controlled trials ( RCTs ) .
Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men
Little is known about the effect of exercise training on the expression of adiponectin receptor genes in peripheral blood mononuclear cells ( P BMC s ) . In this study , we investigated the effects of aerobic training on the expression of AdipoR1 and AidpoR2 mRNAs in P BMC s , whole body insulin sensitivity , and circulating adiponectins in men . Thirty young men were r and omly assigned to either a control ( n=15 ) or an exercise ( n=15 ) group . Subjects assigned to the exercise group underwent a 12-week jogging and /or running programme on a motor-driven treadmill at an intensity of 60%-75 % of the age-based maximum heart rate with duration of 40 minutes per session and a frequency of 5 days per week . Two-way mixed ANOVA with repeated measures was used to test any significant time-by-group interaction effects for the measured variables at p=0.05 . We found significant time-by-group interaction effects for waist circumference ( p=0.001 ) , VO2max ( p<0.001 ) , fasting insulin ( p=0.016 ) , homeostasis model assessment for insulin resistance ( HOMA-IR ) ( p=0.010 ) , area under the curve ( AUC ) for insulin response during the 75-g oral glucose tolerance test ( p=0.002 ) , high-molecular weight ( HMW ) adiponectin ( p=0.016 ) , and the P BMC mRNA levels of AdipoR1 ( p<0.001 ) and AdipoR2 ( p=0.001 ) . The exercise group had significantly increased mRNA levels of AdipoR1 and AdipoR2 in P BMC s , along with increased whole body insulin sensitivity and HMW adiponectin , decreased waist circumference , and increased VO2max compared with the control group . In summary , the current findings suggest that exercise training modulates the expression of AdipoR1 and AdipoR2 mRNAs in P BMC s , implying that manipulation of the expression of these genes could be a potential surrogate for lifestyle intervention-mediated improvements of whole body insulin sensitivity and glucose homeostasis
The meta- analysis showed a significant increase in plasma adiponectin levels following statin therapy .
Although statins are known to increase the risk for new onset diabetes mellitus , our data might suggest that the mechanism for this is unlikely to be due to a reduction in adiponectin expression
BACKGROUND AND AIMS The effect of statin therapy on plasma adiponectin levels has not been conclusively studied .
Therefore , we aim ed to evaluate this effect through a systematic review and meta- analysis of available r and omized controlled trials ( RCTs ) .