Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Effect of Atorvastatin on Type 2 Diabetic Dyslipidemia
Hyperlipidemia is commonly observed in patients with type 2 diabetes and is an independent risk factor for cardiovascular disease . The authors tested the effect of atorvastatin ( 10 mg/d ) on 110 hyperlipidemic type 2 diabetes patients with low-density lipoprotein cholesterol ( LDL-C ) levels exceeding 130 mg/d . The primary efficacy end point was the percentage change in LDL-C and high-density lipoprotein cholesterol ( HDL-C ) , and secondary efficacy included the percentage change in apolipoproteins at weeks 6 , 12 , and 24 . The tertiary goal was percentage change in free radical scavenger enzymes and oxidative stress . LDL-C was reduced by 25 % , 39.3 % , and 49.2 % . A similar trend was observed in total cholesterol , triglyceride , non-HDL-C , and apolipoprotein ( apo ) B-100 . HDL-C was raised by 3.2 % , 6 % , and 8.2 % . A similar trend was seen in apo A-1 . Copper zinc-superoxide dismutase and glutathione were raised significantly ( P < .001 ) ; however , changes in glutathione-S-transferase and glutathione peroxidase activities were nonsignificant . Malondialdehyde was decreased significantly ( P < .001 ) . Atorvastatin improves the lipoprotein profile and oxidative status in patients with type 2 diabetes
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .