Results : Duloxetine may be an effective treatment for mood spectrum disorders , panic disorder , several symptom clusters of borderline personality , and as add-on drug in schizophrenia .
Modest or conflicting results have been found for the efficacy of duloxetine in obsessive-compulsive disorder , posttraumatic stress disorder , eating , and sexual disorders .
Background : Duloxetine hydrochloride ( DUL ) is an antidepressant included in the pharmacological class of serotonin-norepinephrine reuptake inhibitors approved for the treatment of major depressive disorder , generalized anxiety disorder , diabetic peripheral neuropathic pain , fibromyalgia , and chronic musculoskeletal pain .
The aim of this review was to eluci date current evidence s on the use of DUL in the treatment of a variety of psychiatric disorders .
Duloxetine as an Analgesic Reduces Opioid Consumption After Spine Surgery: A Randomized, Double-Blind, Controlled Study
Objectives : Multimodal analgesia is widely advocated for the control of perioperative pain in an effort to reduce the use of opioid . Duloxetine is a selective inhibitor of serotonin and norepinephrine reuptake with efficacy for chronic pain conditions . The primary objective of this study was to evaluate the efficacy of two 60 mg oral doses of duloxetine in terms of fentanyl consumption during the postoperative period in patients undergoing elective spine surgery . Material s and Methods : This study was prospect i ve , double-blind , r and omized , and placebo controlled . Patients received either 60 mg duloxetine or an identical placebo 1 hour before surgery and again the following morning . The study participants were allocated into 2 groups : Group C ( control ) participants received the placebo and Group D ( duloxetine ) participants received 60 mg duloxetine . The total consumption of fentanyl 48 hours after surgery was measured . Secondary end points were pain scores and the presence or absence of adverse effects , such as headache , nausea , vomiting , itching , dizziness , and drowsiness . Results : Demographic characteristics did not differ between groups . There was a significant difference in fentanyl consumption in the first 24 hours between Groups C and D ( mean difference , 223.11±39.32 µg ; P<0.001 ) . Fentanyl consumption also differed between Groups C and D after 48 hours ( mean difference , 179.35±32.55 µg ; P<0.000 ) . The pain scores over 48 hours did not significantly differ between groups . The incidence of side-effects was similar in both groups . Discussion : Duloxetine was effective as an adjunct for postoperative analgesia and reduced opioid consumption
Results : Duloxetine may be an effective treatment for mood spectrum disorders , panic disorder , several symptom clusters of borderline personality , and as add-on drug in schizophrenia .
Modest or conflicting results have been found for the efficacy of duloxetine in obsessive-compulsive disorder , posttraumatic stress disorder , eating , and sexual disorders .
Background : Duloxetine hydrochloride ( DUL ) is an antidepressant included in the pharmacological class of serotonin-norepinephrine reuptake inhibitors approved for the treatment of major depressive disorder , generalized anxiety disorder , diabetic peripheral neuropathic pain , fibromyalgia , and chronic musculoskeletal pain .
The aim of this review was to eluci date current evidence s on the use of DUL in the treatment of a variety of psychiatric disorders .