Best- evidence synthesis demonstrated a conflicting level of evidence for associations between the use of-amphetamine-type substances and the risk of sustaining an injury , and a moderate level of evidence between amphetamine use and the risk of death due to road trauma .
This is the first review to synthesis e evidence regarding the association between amphetamine-type substance use and the risk of injury or death due to a road traffic accident .
More conclusive evidence of death due to road trauma among amphetamine users may reflect significant and global deficits in functioning associated with effective vehicular control under the influence of this substance .
Amphetamine-type substances are frequently detected among drivers injured or killed due to road-trauma .
However , the role of this substance in crash causation remains equivocal .
We performed a systematic review to evaluate existing evidence regarding the association between amphetamine use and the risk of injury or death due to road traffic accidents .
The effect of d-methamphetamine on simulated driving performance.
OBJECTIVES Methamphetamine is considered to be one of the most popularly abused drugs by drivers ; however , its exact effect on driving and driving behaviour has yet to be thoroughly investigated . This being despite methamphetamine 's increased prevalence in injured and deceased drivers . METHODS Twenty healthy recreational illicit stimulant users ( 10 male and 10 female ) , aged between 21 and 32 years ( mean = 25.4 years , SD = 3.3 years ) attended two testing sessions involving oral consumption of 0.42 mg/kg d-methamphetamine or a matching placebo . The drug administration was counter-balanced , double-blind , and medically supervised . At each session driving , performance was assessed 2.5 h post drug administration . RESULTS d-methamphetamine ( 0.42 mg/kg ) did not significantly impair overall simulated driving performance 2.5 h post drug administration . At the individual driving variable level , participants in the d-methamphetamine condition were observed to be driving slower when an emergency situation occurred ( T = 44 , p < 0.05 ) , but interestingly , participants in both conditions recorded average speeds in excess of the speed limit ( 100 km/h ) when the emergency situations occurred . The d-methamphetamine condition did also produce four times more infringements where participants did not stop at red traffic light in comparison to the placebo , but this effect was only evident at a trend level ( T = 7 , p = 0.11 ) . CONCLUSIONS The findings presented herein suggest that d-methamphetamine administered at the levels supplied did not impair driving performance in a manner consistent with epidemiological evidence . Further research is certainly required to eluci date the effects of various doses of methamphetamine , alone and in combination with other legal and illicit substances
Best- evidence synthesis demonstrated a conflicting level of evidence for associations between the use of-amphetamine-type substances and the risk of sustaining an injury , and a moderate level of evidence between amphetamine use and the risk of death due to road trauma .
This is the first review to synthesis e evidence regarding the association between amphetamine-type substance use and the risk of injury or death due to a road traffic accident .
More conclusive evidence of death due to road trauma among amphetamine users may reflect significant and global deficits in functioning associated with effective vehicular control under the influence of this substance .
Amphetamine-type substances are frequently detected among drivers injured or killed due to road-trauma .
However , the role of this substance in crash causation remains equivocal .
We performed a systematic review to evaluate existing evidence regarding the association between amphetamine use and the risk of injury or death due to road traffic accidents .