Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .
Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes.
Statins and fibrates influence endothelial activity and consequently atherogenesis but the mechanisms are not well understood . Twenty Type 2 diabetic patients with dyslipidemia were treated 3 months with simvastatin ( 20 mg daily ) and then 3 months with fenofibrate ( 200 mg daily ) with 2 months of wash-out between the two treatments . Laboratory parameters of oxidative stress , fibrinolysis and endothelial function were evaluated before and at the end of each treatment period . The significant decrease in serum total and LDL-cholesterol concentrations ( P<0.0001 ) caused by simvastatin was associated with an increase in serum N-acetyl-beta-glucosaminidase activity ( P<0.001 ) , ascorbic acid ( P<0.001 ) , plasminogen activator inhibitor ( PAI-1 ) ( P<0.01 ) , vonWillebr and factor ( P<0.05 ) , E-selectin ( P<0.01 ) and vascular endothelial growth factor ( P<0.05 ) concentrations and with a decrease in plasma glutathione ( P<0.01 ) levels . Fenofibrate caused a significant decrease in serum triglyceride concentration ( P<0.0001 ) associated with a decrease in plasma malondialdehyde ( P<0.001 ) and an increase in plasma PAI-1 ( P<0.05 ) and P-selectin ( P<0.05 ) concentrations . We conclude that simvastatin and fenofibrate interact , by different mechanisms , with oxidative stress , a key factor in the modification of fibrinolysis and endothelial function in Type 2 diabetes
Conclusions : This systematic review and meta- analysis showed that statin treatment significantly reduces systemic MDA concentrations .
Background : The effect of statins on oxidative stress markers , such as malondialdehyde ( MDA ) , is still a matter of debate .
We sought to address this issue by conducting a systematic review and meta- analysis of published data on the effect of statin treatment on systemic MDA concentrations .