Adherence to DASH diet is effective in improving circulating serum inflammatory biomarkers in adults , compared with usual diet ; therefore , it could be a valuable strategy to suppress inflammation process
BACKGROUND & AIMS Dietary approaches to stop hypertension ( DASH ) diet is associated with improved blood pressure and risk of cardiovascular diseases .
It is proposed that DASH might also improve systemic inflammatory markers like highly sensitive C-reactive protein ( hs-CRP ) ; however , interventional studies have led to conflicting results .
The aim of current systematic review was to summarize results of r and omized clinical trials examining the effect of DASH on inflammatory biomarkers .
C-Reactive Protein and Prediction of Coronary Heart Disease and Global Vascular Events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
Background — The role of C-reactive protein ( CRP ) in predicting vascular events and response to statin therapy remains uncertain . Additional large prospect i ve studies are required . Methods and Results — Baseline CRP was related to risk over 3.2 years for primary a combined end point ( definite or suspected death from coronary heart disease , nonfatal myocardial infa rct ion , and fatal or nonfatal stroke ; n=865 events ) and secondary ( coronary heart disease events or stroke alone ) and tertiary ( stroke plus transient ischemic attack ) end points in the Prospect i ve Study of Pravastatin in the Elderly at Risk ( n=5804 men and women ; age , 70 to 82 years ) .  CRP levels were higher in subjects who had a subsequent primary end-point event compared with those who did not ( geometric mean ; 3.64 mg/L [ SD , 3.08 mg/L ] versus 3.01 mg/L [ SD , 3.05 mg/L ] ; P<0.0001 ) . CRP correlated positively with body mass index and smoking status and negatively with high-density lipoprotein cholesterol . The unadjusted hazard ratio for the primary end point was 1.48 ( 95 % CI , 1.26 to 1.74 ) in a comparison of top and bottom thirds for CRP , falling to 1.36 ( 95 % CI , 1.15 to 1.61 ) with adjustment for established predictors and body mass index . Similar results were obtained for other end points or when results were examined separately by history of vascular disease . However , baseline CRP added minimally to risk prediction beyond conventional predictors and did not relate to the magnitude of pravastatin benefit . Conclusions — Elevated CRP minimally enhances cardiovascular disease prediction beyond established vascular risk factors and does not predict response to statin therapy in elderly subjects at risk . These data suggest that CRP has limited clinical value in cardiovascular disease risk stratification or predicting response to statin therapy in elderly people
Adherence to DASH diet is effective in improving circulating serum inflammatory biomarkers in adults , compared with usual diet ; therefore , it could be a valuable strategy to suppress inflammation process
BACKGROUND & AIMS Dietary approaches to stop hypertension ( DASH ) diet is associated with improved blood pressure and risk of cardiovascular diseases .
It is proposed that DASH might also improve systemic inflammatory markers like highly sensitive C-reactive protein ( hs-CRP ) ; however , interventional studies have led to conflicting results .
The aim of current systematic review was to summarize results of r and omized clinical trials examining the effect of DASH on inflammatory biomarkers .