Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .
Effects of different hypocaloric diets on protein secretion from adipose tissue of obese women.
Little is known about common factors ( e.g. , macronutrients and energy supply ) regulating the protein secretory function of adipose tissue . We therefore compared the effects of r and omly assigned 10-week hypoenergetic ( -600 kcal/day ) diets with moderate-fat/moderate-carbohydrate or low-fat/high-carbohydrate content on circulating levels and production of proteins ( using radioimmunoassays and enzyme-linked immunosorbent assays ) from subcutaneous adipose tissue in 40 obese but otherwise healthy women . Similar results were obtained by the two diets .  Body weight decreased by approximately 7.5 % . The secretion rate of leptin decreased by approximately 40 % , as did that of tumor necrosis factor-alpha ( TNF-alpha ) , and interleukin (IL)-6 and -8 decreased by 25 - 30 % , whereas the secretion of plasminogen activator inhibitor 1 ( PAI-1 ) and adiponectin did not show any changes . Regarding mRNA expression ( by real-time PCR ) , only that of leptin and IL-6 decreased significantly . Circulating levels of leptin and PAI-1 decreased by 30 and 40 % , respectively , but there were only minor changes in circulating TNF-alpha , IL-6 , or adiponectin . In conclusion , moderate caloric restriction but not macronutrient composition influences the production and secretion of adipose tissue-derived proteins during weight reduction , leptin being the most sensitive and adiponectin and PAI-1 the least sensitive
Weight loss diet beneficially affects blood adiponectin concentrations .
Adiponectin secreted from adipose tissue is proposed to be inversely related to the body fat mass .
However , the magnitude of the effect of low calorie diet on adiponectin concentrations remains unknown .
The present study was aim ed to conduct a systematic review and meta- analysis on clinical trials that access the effect of low calorie diet on adiponectin concentration .