Exposure to H2 receptor antagonists may be associated with increased risk of NEC and infections in preterm infants
BACKGROUND Inhibitors of gastric acid ( IGA ) are used for upper gastrointestinal bleeding or gastroesophageal reflux in preterm infants .
The result ant increase in gastric pH may enhance the growth of pathogens and increase the risk of necrotizing enterocolitis ( NEC ) .
Our systematic review examined the association between  IGA and NEC in preterm infants .
Bacterial translocation and intestinal injury in experimental necrotizing enterocolitis model.
OBJECTIVE To study the occurrence of bacterial translocation and to assess the impact of breastfeeding on bacterial translocation in the animal model of necrotizing enterocolitis . METHODS A total of 20 neonate Sprague-Dawley rats were enrolled in the study . Rats were r and omly allocated into either control or study group just after birth . Ten newborn rats in the control group were left with their mother to be breast-fed . In contrary , necrotizing enterocolitis group consisted of neonates that were separated from their mothers , housed in an incubator and were gavaged with a special rodent formula three times daily .  Survival rates , weight changes , and morphologic scoring obtained after microscopic evaluation were determined as microbiologic evaluation criteria . RESULTS All the rats in the control group survived , while 1 ( 10 % ) rat died in the necrotizing enterocolitis group . Mortality rates of the two groups were similar . All the formula-fed animals in the necrotizing enterocolitis group had significant weight loss compared to the breast milk-fed rats in the control group ( p<0.05 ) . A total of 7 ( 70 % ) and 2 ( 20 % ) E. coli growths were identified in the bowel lumen , liver , and spleen of necrotizing enterocolitis and control groups , respectively . This difference was statistically significant . In peritoneal smear cultures , a total of 3 ( 30 % ) growths were detected in the necrotizing enterocolitis group and 1 ( 10 % ) growth in the control group . CONCLUSION As the result of a disturbance in the intestinal flora and impairment of the intestinal barrier in necrotizing enterocolitis , microrganisms in the bowel pass through the intestinal barrier and reach the liver and the spleen via the hematogenous route . This condition is closely related to the impairment of physiological and functional features of the intestinal barrier and is independent from the degree of intestinal injury . Bacterial translocation should be remembered in cases suspected of necrotizing enterocolitis , and a rapid and effective treatment algorithm should be applied in such circumstances ( Tab . 3 , Fig. 3 , Ref . 21 ) . Full Text in PDF www.elis.sk
Exposure to H2 receptor antagonists may be associated with increased risk of NEC and infections in preterm infants
BACKGROUND Inhibitors of gastric acid ( IGA ) are used for upper gastrointestinal bleeding or gastroesophageal reflux in preterm infants .
The result ant increase in gastric pH may enhance the growth of pathogens and increase the risk of necrotizing enterocolitis ( NEC ) .
Our systematic review examined the association between  IGA and NEC in preterm infants .