The present study revealed that supplementation with ALA slightly but significantly decreased body weight and BMI .
Safe dosage for ALA is up to 1200 mg/day .
However , it seems that ALA can not be cost-effective .
BACKGROUND & AIMS Previous studies have supported positive roles of antioxidant supplements on  weight-loss .
One antioxidant supplement is Alpha-lipoic acid .
However , recommending ALA as an anti-obesity supplement remains controversial .
Accordingly , the purpose of the present study was to perform a meta- analysis on the effects of ALA supplement on anthropometric indices  among adult subjects .
Better dietary adherence and weight maintenance achieved by a long-term moderate-fat diet.
The objective of the present study was to determine the effects of a long-term moderate-fat diet ( 30 % energy from fat ) v. a low-fat one ( 20 % energy from fat ) on metabolic risks . The study was a r and omised , prospect i ve 14-month trial on overweight and obese patients ( eighty-nine overweight and obese men and women ) . The intervention was a moderate-fat diet ( 30 % energy ) or a low-fat diet ( 20 % energy ) . The main outcome measurements were change in body weight , waist circumference , LDL-cholesterol , HDL-cholesterol , total cholesterol , TAG , and systolic and diastolic blood pressure .  Forty-five subjects on the moderate-fat diet and forty-four subjects on the low-fat one were studied . Characteristics of all r and omised participants were similar in both groups . After 7 months , the moderate- and low-fat diets had similar effects on cardiovascular risks . The moderate-fat diet was more successful after 14 months in reducing weight ( -5.0 ( SD 2.5 ) kg in the moderate-fat group v. -1.2 ( SD 1.1 ) kg in the low-fat one ; P < 0.0001 ) , waist circumference ( -5.5 ( SD 2.4 ) cm in the moderate-fat group v. - 2.3 ( SD 1.3 ) cm in the low-fat one ; P < 0.0001 ) , and other cardiovascular risk factors as well ( LDL , TAG , total cholesterol and systolic blood pressure ) . In conclusion , a moderate-fat energy-restricted diet in the long term might have more beneficial effects on weight maintenance and cardiovascular risk factors compared with a low-fat diet . Better dietary adherence with the moderate-fat diet may be the reason for its successful effects
The present study revealed that supplementation with ALA slightly but significantly decreased body weight and BMI .
Safe dosage for ALA is up to 1200 mg/day .
However , it seems that ALA can not be cost-effective .
BACKGROUND & AIMS Previous studies have supported positive roles of antioxidant supplements on  weight-loss .
One antioxidant supplement is Alpha-lipoic acid .
However , recommending ALA as an anti-obesity supplement remains controversial .
Accordingly , the purpose of the present study was to perform a meta- analysis on the effects of ALA supplement on anthropometric indices  among adult subjects .