Cognitive behavioral therapy may reduce relapse risk for adults with AN after weight restoration , although its efficacy in the underweight state remains unknown .
Variants of family therapy are efficacious in adolescents , but not in adults .
Evidence for AN treatment is weak ; evidence for treatment-related harms and factors associated with efficacy of treatment are weak ; and evidence for differential outcome by sociodemographic factors is nonexistent .
OBJECTIVE The RTI International-University of North Carolina at Chapel Hill Evidence -based Practice Center ( RTI-UNC EPC ) systematic ally review ed evidence on efficacy of treatment for anorexia nervosa ( AN ) , harms associated with treatments , factors associated with treatment efficacy , and differential outcome by sociodemographic characteristics .
Predictors of treatment acceptance and completion in anorexia nervosa: implications for future study designs.
CONTEXT There have been very few r and omized controlled treatment studies of anorexia nervosa . OBJECTIVE To evaluate factors leading to nonacceptance and noncompletion of treatment for 2 specific therapies and their combination in the treatment of anorexia nervosa . DESIGN R and omized prospect i ve study . SETTING Weill-Cornell Medical Center , White Plains , NY ; University of Minnesota , Minneapolis ; and Stanford University , Stanford , Calif. Patients One hundred twenty-two patients meeting DSM-IV criteria for anorexia nervosa . INTERVENTIONS Treatment with cognitive-behavioral therapy , fluoxetine hydrochloride , or their combination for 1 year . MAIN OUTCOME MEASURES Dropout rate and acceptance of treatment ( defined as staying in treatment at least 5 weeks ) . RESULTS Of the 122 r and omized cases , 21 ( 17 % ) were withdrawn ; the overall dropout rate was 46 % ( 56/122 ) in the remaining patients . Treatment acceptance occurred in 89 ( 73 % ) of the 122 r and omized cases . Of the 41 assigned to medication alone , acceptance occurred in 23 ( 56 % ) . In the other 2 groups , acceptance rate was differentiated by high and low obsessive preoccupation scores ( rates of 91 % and 60 % , respectively ) . The only predictor of treatment completion was high self-esteem , which was associated with a 51 % rate of treatment acceptance . CONCLUSION Acceptance of treatment and relatively high dropout rates pose a major problem for research in the treatment of anorexia nervosa . Differing characteristics predict dropout rates and acceptance , which need to be carefully studied before comparative treatment trials are conducted
Cognitive behavioral therapy may reduce relapse risk for adults with AN after weight restoration , although its efficacy in the underweight state remains unknown .
Variants of family therapy are efficacious in adolescents , but not in adults .
Evidence for AN treatment is weak ; evidence for treatment-related harms and factors associated with efficacy of treatment are weak ; and evidence for differential outcome by sociodemographic factors is nonexistent .
OBJECTIVE The RTI International-University of North Carolina at Chapel Hill Evidence -based Practice Center ( RTI-UNC EPC ) systematic ally review ed evidence on efficacy of treatment for anorexia nervosa ( AN ) , harms associated with treatments , factors associated with treatment efficacy , and differential outcome by sociodemographic characteristics .