The benefits of antioxidants or DHA/EPA supplementation for CF , although observed in some studies , are not consistent enough to recommend routine use of these supplements .
Antioxidant micronutrients and essential fatty acids supplementation intake appears to have a protective effect in some diseases such as cardiovascular disease , cancer , and asthma .
The aim of this study was to perform a systematic review to evaluate the effects of these nutrients on nutritional and clinical outcomes of patients with cystic fibrosis ( CF ) .
This is a systematic review of r and omized clinical trials ( RCTs ) in CF .
Zinc Supplementation for One Year Among Children with Cystic Fibrosis Does Not Decrease Pulmonary Infection
BACKGROUND : Children with cystic fibrosis may have a deficiency of micronutrients , including zinc , which may affect their susceptibility to infections . There is a paucity of data on zinc supplementation among children with cystic fibrosis . We hypothesized that a pharmacologic dose of zinc administered daily for 12 months would reduce the need for antibiotics by 50 % . METHODS : This double-blind r and omized placebo-controlled trial was conducted among children with cystic fibrosis to assess the effect of zinc supplementation on the need for antibiotics and pulmonary function tests .  The children , age 5–15 y , of either sex , received either 30-mg zinc tablets or similar looking placebo tablets daily in addition to st and ard care . They were followed up every month for a period of 12 months and whenever they had pulmonary exacerbations . Their serum zinc was estimated at baseline and at 12 months of enrollment . During each visit , the children underwent a pulmonary function test and sputum culture . RESULTS : Of a total of 43 children screened , 40 were enrolled , and of them , 37 completed the study . The median ( interquartile range ) number of days of the administration of antibiotics over 12 months of follow-up among the children receiving zinc was 42 ( 14–97 ) d. In the placebo group , it was 38 ( 15–70 ) d ( P = .79 ) . There were no significant differences in the percent-of-predicted FEV1 or change in FEV1 values at 12 months ( P = .44 ) . The number of children in whose respiratory specimens Pseudomonas was isolated was similar for the 2 groups at different time intervals . The adverse events reported were similar in the 2 groups . CONCLUSION : We did not find any significant difference in the need for antibiotics , pulmonary function tests , hospitalization , colonization with Pseudomonas , or the need for antibiotics for children with cystic fibrosis receiving zinc supplementation of 30 mg/d
The benefits of antioxidants or DHA/EPA supplementation for CF , although observed in some studies , are not consistent enough to recommend routine use of these supplements .
Antioxidant micronutrients and essential fatty acids supplementation intake appears to have a protective effect in some diseases such as cardiovascular disease , cancer , and asthma .
The aim of this study was to perform a systematic review to evaluate the effects of these nutrients on nutritional and clinical outcomes of patients with cystic fibrosis ( CF ) .
This is a systematic review of r and omized clinical trials ( RCTs ) in CF .