Outcomes , such as range of motion , recurrence , and clinical success , were frequently defined , however many different definitions were used .
This systematic review summarizes the outcome reporting st and ards in Dupuytren ’s disease treatment research .
Collagenase Clostridium Histolyticum versus Limited Fasciectomy for Dupuytren’s Contracture: Outcomes from a Multicenter Propensity Score Matched Study
Background : Controversy exists about the relative effectiveness of injectable collagenase ( collagenase clostridium histolyticum ) and limited fasciectomy in the treatment of Dupuytren ’s contracture . The authors compared the effectiveness of both techniques in actual clinical practice . Methods : This study evaluated all subjects treated with collagenase clostridium histolyticum or limited fasciectomy for metacarpophalangeal and /or proximal interphalangeal joint contractures between 2011 and 2014 at seven practice sites . The authors compared the degree of residual contracture ( active extension deficit ) , Michigan H and Outcomes Question naire scores , and adverse events at follow-up visits occurring between 6 and 12 weeks after surgery or the last injection with the use of propensity score matching . Results : In 132 matched subjects who were treated with collagenase ( n = 66 ) or fasciectomy ( n = 66 ) , the degree of residual contracture at follow-up for affected metacarpophalangeal joints was not significantly different ( 13 degrees versus 6 degrees ; p = 0.095 ) and affected proximal interphalangeal joints had significantly worse residual contracture in the collagenase group compared with those in the fasciectomy group ( 25 degrees versus 15 degrees ; p = 0.010 ) . Collagenase subjects experienced fewer serious adverse events than did fasciectomy subjects and reported larger improvements in the Michigan H and Outcomes Question naire subscores evaluating satisfaction with h and function , activities of daily living , and work performance . Conclusions : This propensity score – matched study showed that collagenase clostridium histolyticum was not significantly different from limited fasciectomy in reducing metacarpophalangeal joint contractures , whereas proximal interphalangeal joint contractures showed slightly better reduction following limited fasciectomy . Collagenase provided a more rapid recovery of h and function than did fasciectomy and was associated with fewer serious adverse events . CLINICAL QUESTION /LEVEL OF EVIDENCE : Therapeutic , III
Outcomes , such as range of motion , recurrence , and clinical success , were frequently defined , however many different definitions were used .
This systematic review summarizes the outcome reporting st and ards in Dupuytren ’s disease treatment research .