Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .
The effects of exogenous testosterone on sexuality and mood of normal men.
The effects of supraphysiological levels of testosterone , used for male contraception , on sexual behavior and mood were studied in a single-blind , placebo-controlled manner in a group of 31 normal men . After 4 weeks of baseline observations , the men were r and omized into two groups : one group received 200 mg testosterone enanthate ( TE ) weekly by i m injection for 8 weeks ( Testosterone Only group ) , the other received placebo injections once weekly for the first 4 weeks followed by TE 200 mg weekly for the following 4 weeks ( Placebo/Testosterone group ) . The testosterone administration increased trough plasma testosterone levels by 80 % , compatible with peak testosterone levels 400 - 500 % above baseline . Various aspects of sexuality were assessed using sexuality experience scales ( SES ) question naires at the end of each 4-week period while sexual activity and mood states were recorded by daily dairies and self-rating scales . In both groups there was a significant increase in scores in the Psychosexual Stimulation Scale of the SES ( i.e. SES 2 ) following testosterone administration , but not with placebo . There were no changes in SES 3 , which measures aspects of sexual interaction with the partner . In both groups there were no changes in frequency of sexual intercourse , masturbation , or penile erection on waking nor in any of the moods reported . The Placebo/Testosterone group showed an increase in self-reported interest in sex during testosterone treatment but not with placebo . The SES 2 results suggest that sexual awareness and arousability can be increased by supraphysiological levels of testosterone . However , these changes are not reflected in modifications of overt sexual behavior , which in eugonadal men may be more determined by sexual relationship factors . This contrasts with hypogonadal men , in whom testosterone replacement clearly stimulates sexual behavior . There was no evidence to suggest an alteration in any of the mood states studied , in particular those associated with increased aggression . We conclude that supraphysiological levels of testosterone maintained for up to 2 months can promote some aspects of sexual arousability without stimulating sexual activity in eugonadal men within stable heterosexual relationships . Raising testosterone does not increase self-reported ratings of aggressive feelings
Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .