None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .
Double-blind study of glycerol vs glucose in parenteral nutrition of postsurgical insulin-treated diabetic patients.
Twenty-five insulin-treated diabetic patients were r and omly assigned postoperatively to 5 days of intravenous infusions of ProcalAmine ( 3 % amino acids , 3 % glycerol , and electrolytes ) or FreAmineIII + dextrose and electrolytes . The solutions were given isocalorically and isonitrogenously . Insulin was adjusted to keep glycemia at the level of 150 - 200 mg/dl . The ProcalAmine group by the 5th day had plasma glucose of 158 + /- 25 mg/dl and required 1.20 + /- 0.10 U/hr insulin . The FreAmine + dextrose group had plasma glucose of 169 + /- 53 mg/dl and required 2.28 + /- 0.13 U/hr . At all time points postsurgically , the ProcalAmine group required less insulin
None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .