Leptin levels decreased as BMI decreased .
Evidence regarding the relationships of ghrelin and adiponectin with BMI was inconclusive .
Conclusions : Despite known effects of maturation on hormones , studies did not consistently differentiate findings by maturational stage .
BMI and leptin levels have a positive relationship , but evidence on ghrelin and adiponectin was inconclusive
Problem : To address the complex phenomenon of pediatric obesity , one must underst and the physiological mechanisms regulating energy intake and inflammation .
The peptide hormones leptin , ghrelin , and adiponectin are involved in both , but their functions are dysregulated in obesity .
The purpose of this systematic review is ( 1 ) to characterize studies of nutrition interventions for weight management in children who measure these peptides as outcomes , ( 2 ) to assess risk of bias in the studies , and ( 3 ) to determine the relationships between these peptides and body mass index ( BMI ) .
Interdisciplinary therapy changes superoxide dismutase activity and adiponectin in obese adolescents: a randomised controlled trial
Abstract The objective of this study is to evaluate the effect of interdisciplinary therapy in the parameters of the oxidative stress and the anti-inflammatory responses of obese adolescents . We selected 57 participants , who were r and omly divided into 2 groups : interdisciplinary therapy group and a control group . After 6 months of intervention , 17 participants of the interdisciplinary therapy group and 8 of the control group returned for re-evaluation . The interdisciplinary therapy group participated in a treatment with 4 weekly sessions of exercise , a weekly group therapy session and a weekly nutritional education session .  Blood parameters of oxidative stress and anti-inflammatory response were evaluated . The results demonstrated that there were significant increases in the interdisciplinary therapy group for superoxide dismutase activity ( 6.56 ± 3.22 to 11.40 ± 7.49 ) and ferric-reducing antioxidant potential concentration ( 532.91 ± 106.48 to 573.25 ± 112.57 ) , although adiponectin levels did not reduce ( 40.9 ± 29.34 to 49.05 ± 41.22 ) . A significant decrease in nitrite levels was also found ( 14.23 ± 8.48 to 11.45 ± 6.05 ) . In the control group , significant reduction was found in adiponectin ( 31.56 ± 18.88 to 18.01 ± 11.66 ) . This study suggests that interdisciplinary therapy for 6 months was effective in improving the anti-inflammatory responses and the antioxidant defences in obese adolescents
Leptin levels decreased as BMI decreased .
Evidence regarding the relationships of ghrelin and adiponectin with BMI was inconclusive .
Conclusions : Despite known effects of maturation on hormones , studies did not consistently differentiate findings by maturational stage .
BMI and leptin levels have a positive relationship , but evidence on ghrelin and adiponectin was inconclusive
Problem : To address the complex phenomenon of pediatric obesity , one must underst and the physiological mechanisms regulating energy intake and inflammation .
The peptide hormones leptin , ghrelin , and adiponectin are involved in both , but their functions are dysregulated in obesity .
The purpose of this systematic review is ( 1 ) to characterize studies of nutrition interventions for weight management in children who measure these peptides as outcomes , ( 2 ) to assess risk of bias in the studies , and ( 3 ) to determine the relationships between these peptides and body mass index ( BMI ) .