The review of trials identifies positive effects of these nutrients on various outcome measures relating to insulin resistance and cardiovascular factors .
A majority of the trials found a positive effect of chromium on fasting plasma glucose .
Isoflavones were found to have a positive effect on insulin resistance and cardiovascular outcome measures , but only when combined with soy proteins .
Vitamin E is reported to reduce oxidative stress at levels of 200 mg day(-1 ) or more
The role of nutritional supplementation is of increasing interest with regard to ocular disease .
R and omised controlled trials have demonstrated the effectiveness of supplementation for age-related macular degeneration , and formulations are now being developed for use by people with diabetes and diabetic retinopathy .
The aim of this review was to synthesis e the evidence for use of nutritional supplementation in type 2 diabetes .
The potential role of alpha-lipoic acid , chromium , folic acid , isoflavones , magnesium , Pycnogenol , selenium , vitamin C , vitamin E , and zinc in the treatment of type 2 diabetes is discussed .
Effect of tocopherol on platelet aggregation in non-insulin-dependent diabetes mellitus: ex vivo and in vitro studies.
Tocopherol has been shown to have antiplatelet effects in insulin-dependent diabetes mellitus . However , its antiplatelet effect in non-insulin-dependent diabetes mellitus ( NIDDM ) remains to be established . In this report , the antiplatelet effect of tocopherol was assessed in a r and omized , double-blind and crossover study of 15 NIDDM subjects . Each subject received tocopherol ( dl-alpha-tocopherol nicotinate , 200 mg , tid ) and a placebo for two six-week treatment periods separated by a three-week period in between for wash-out . The mechanisms of the antiplatelet effect of tocopherol were also studied in vitro . A significant decrease in platelet reactivity was observed after tocopherol treatment as compared with the pretest , and the magnitude of the decrease during tocopherol treatment was significantly evident when compared with that of the placebo treatment , as assessed by collagen ( 5 , 10 micrograms/mL)-induced platelet aggregation of whole blood . A dose-dependent reduction in both ADP- and collagen-induced platelet aggregation was observed with tocopherol from 0.1 to 3.0 mM in vitro . No corresponding changes in ATP secretion and thromboxane synthesis were observed . Tocopherol also significantly inhibited fibrinogen-induced aggregation of elastase-treated platelets at a concentration of 0.1 mM. We demonstrated that platelet aggregation of whole blood ex vivo , among 15 NIDDM subjects was suppressed in tocopherol treatment , so tocopherol may have an antiplatelet effect in NIDDM subjects . The inhibitory effect of the platelet aggregation of tocopherol may be partially accomplished through interference with fibrinogen binding towards its receptor
The review of trials identifies positive effects of these nutrients on various outcome measures relating to insulin resistance and cardiovascular factors .
A majority of the trials found a positive effect of chromium on fasting plasma glucose .
Isoflavones were found to have a positive effect on insulin resistance and cardiovascular outcome measures , but only when combined with soy proteins .
Vitamin E is reported to reduce oxidative stress at levels of 200 mg day(-1 ) or more
The role of nutritional supplementation is of increasing interest with regard to ocular disease .
R and omised controlled trials have demonstrated the effectiveness of supplementation for age-related macular degeneration , and formulations are now being developed for use by people with diabetes and diabetic retinopathy .
The aim of this review was to synthesis e the evidence for use of nutritional supplementation in type 2 diabetes .
The potential role of alpha-lipoic acid , chromium , folic acid , isoflavones , magnesium , Pycnogenol , selenium , vitamin C , vitamin E , and zinc in the treatment of type 2 diabetes is discussed .