Our meta‐ analysis showed beneficial effects  of statin use  on reducing inflammatory markers in patients with MetS and related disorders
& NA ; Current evidence suggests that statin use decreases the incidence of cardiovascular diseases ( CVD ) through reducing LDL cholesterol and decreasing inflammation .
Metabolic syndrome ( MetS ) is usually associated with increased inflammatory markers and increased risk of CVD .
Vascular effects of diet and statin in hypercholesterolemic patients.
OBJECTIVE We investigated whether statin improves nitric oxide ( NO ) bioactivity and reduces serological markers of oxidant stress and inflammation and whether statin-induced reduction in markers of oxidant stress and inflammation is mediated by improvement in NO bioactivity or lipoprotein changes , compared with American Heart Association Step I Diet ( Diet ) . METHODS We administered diet+placebo and diet+simvastatin 20 mg daily during 14 weeks with r and omized order to 31 and 32 patients with coronary artery disease , respectively , with a r and omized design . RESULTS Compared with diet alone , simvastatin significantly improved the percent flow-mediated dilator response to hyperemia and lowered plasma levels of tumor necrosis factor (TNF)-alpha , intercellular adhesion molecule type-1 ( ICAM-1 ) , serum levels of CRP , and fibrinogen ( P<0.001 , P<0.001 , P=0.035 , P<0.001 and P=0.014 , respectively ) . Compared with diet alone , simvastatin lowered but statistically insignificant plasma levels of nitrate and malondialdehyde ( MDA ) ( P=0.164 and P=0.150 , respectively ) . Further , we observed that patients with the highest pretreatment TNF-alpha , ICAM-1 , and CRP levels showed the greatest extent of reductions on simvastatin . There were significant inverse correlation between low-density lipoprotein ( LDL ) cholesterol or the ratio of LDL to HDL cholesterol levels and flow-mediated dilation percent ( r=-0.342 , P=0.009 and r=-0.356 , P=0.006 , respectively ) . Of interest , there were significant inverse correlations between flow-mediated dilation percent and TNF-alpha levels ( r=-0.329 , P=0.010 ) . However , no significant correlations between lipoprotein levels and levels of inflammation markers were determined . Despite the significant changes of lipoproteins , diet alone did not decrease the markers of inflammation . CONCLUSIONS Compared with diet alone , simvastatin significantly reduced markers of inflammation more . These effects were independent of lipoprotein changes
Our meta‐ analysis showed beneficial effects  of statin use  on reducing inflammatory markers in patients with MetS and related disorders
& NA ; Current evidence suggests that statin use decreases the incidence of cardiovascular diseases ( CVD ) through reducing LDL cholesterol and decreasing inflammation .
Metabolic syndrome ( MetS ) is usually associated with increased inflammatory markers and increased risk of CVD .