Conclusions This meta- analysis has provided evidence that RS supplementation can improve fasting glucose , fasting insulin , insulin resistance and sensitivity , especially for diabetic with overweight or obesity .
Background The role of resistant starch ( RS ) in glucose , insulin , insulin resistance or sensitivity , and lipid parameters have been reported in several studies and remained controversial .
A pooled analysis which assessed these parameters has not been performed .
Thus , we conducted a meta- analysis to sum up existing evidence about the issue .
Impact of Resistant Starch on Body Fat Patterning and Central Appetite Regulation
Background Adipose tissue patterning has a major influence on the risk of developing chronic disease . Environmental influences on both body fat patterning and appetite regulation are not fully understood . This study was performed to investigate the impact of resistant starch ( RS ) on adipose tissue deposition and central regulation of appetite in mice . Methodology and Principle Findings Forty mice were r and omised to a diet supplemented with either the high resistant starch ( HRS ) , or the readily digestible starch ( LRS ) . Using 1H magnetic resonance ( MR ) methods , whole body adiposity , intrahepatocellular lipids ( IHCL ) and intramyocellular lipids ( IMCL ) were measured . Manganese-enhanced MRI ( MEMRI ) was used to investigate neuronal activity in hypothalamic regions involved in appetite control when fed ad libitum . At the end of the interventional period , adipocytes were isolated from epididymal adipose tissue and fasting plasma collected for hormonal and adipokine measurement . Mice on the HRS and LRS diet had similar body weights although total body adiposity , subcutaneous and visceral fat , IHCL , plasma leptin , plasma adiponectin plasma insulin/glucose ratios was significantly greater in the latter group . Adipocytes isolated from the LRS group were significantly larger and had lower insulin-stimulated glucose uptake . MEMRI data obtained from the ventromedial and paraventricular hypothalamic nuclei suggests a satiating effect of the HRS diet despite a lower energy intake . Conclusion and Significance Dietary RS significantly impacts on adipose tissue patterning , adipocyte morphology and metabolism , glucose and insulin metabolism , as well as affecting appetite regulation , supported by changes in neuronal activity in hypothalamic appetite regulation centres which are suggestive of satiation
Conclusions This meta- analysis has provided evidence that RS supplementation can improve fasting glucose , fasting insulin , insulin resistance and sensitivity , especially for diabetic with overweight or obesity .
Background The role of resistant starch ( RS ) in glucose , insulin , insulin resistance or sensitivity , and lipid parameters have been reported in several studies and remained controversial .
A pooled analysis which assessed these parameters has not been performed .
Thus , we conducted a meta- analysis to sum up existing evidence about the issue .