Collectively , findings suggest that yogic practice s may promote significant improvements in several indices of importance in DM2 management , including glycemic control , lipid levels , and body composition .
More limited data suggest that yoga may also lower oxidative stress and blood pressure ; enhance pulmonary and autonomic function , mood , sleep , and quality of life ; and reduce medication use in adults with DM2 .
A growing body of evidence suggests yogic practice s may benefit adults with type 2 diabetes ( DM2 ) .
In this systematic review , we evaluate available evidence from prospect i ve controlled trials regarding the effects of yoga-based programs on specific health outcomes pertinent to DM2 management .
Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial
BACKGROUND Although yoga and meditation have been used for stress reduction with reported improvement in inflammation , little is known about the biological mechanisms mediating such effects . The present study examined if a yogic meditation might alter the activity of inflammatory and antiviral transcription control pathways that shape immune cell gene expression . METHODS Forty-five family dementia caregivers were r and omized to either Kirtan Kriya Meditation ( KKM ) or Relaxing Music ( RM ) listening for 12 min daily for 8 weeks and 39 caregivers completed the study .  Genome-wide transcriptional profiles were collected from peripheral blood leukocytes sample d at baseline and 8-week follow-up . Promoter-based bioinformatics analyses tested the hypothesis that observed transcriptional alterations were structured by reduced activity of the pro-inflammatory nuclear factor (NF)-κB family of transcription factors and increased activity of Interferon Response Factors ( IRFs ; i.e. , reversal of patterns previously linked to stress ) . RESULTS In response to KKM treatment , 68 genes were found to be differentially expressed ( 19 up-regulated , 49 down-regulated ) after adjusting for potentially confounded differences in sex , illness burden , and BMI . Up-regulated genes included immunoglobulin-related transcripts . Down-regulated transcripts included pro-inflammatory cytokines and activation-related immediate-early genes . Transcript origin analyses identified plasmacytoid dendritic cells and B lymphocytes as the primary cellular context of these transcriptional alterations ( both p<.001 ) . Promoter-based bioinformatic analysis implicated reduced NF-κB signaling and increased activity of IRF1 in structuring those effects ( both p<.05 ) . CONCLUSION A brief daily yogic meditation intervention may reverse the pattern of increased NF-κB-related transcription of pro-inflammatory cytokines and decreased IRF1-related transcription of innate antiviral response genes previously observed in healthy individuals confronting a significant life stressor
Collectively , findings suggest that yogic practice s may promote significant improvements in several indices of importance in DM2 management , including glycemic control , lipid levels , and body composition .
More limited data suggest that yoga may also lower oxidative stress and blood pressure ; enhance pulmonary and autonomic function , mood , sleep , and quality of life ; and reduce medication use in adults with DM2 .
A growing body of evidence suggests yogic practice s may benefit adults with type 2 diabetes ( DM2 ) .
In this systematic review , we evaluate available evidence from prospect i ve controlled trials regarding the effects of yoga-based programs on specific health outcomes pertinent to DM2 management .