We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
Soy consumption is not a risk factor for peanut sensitization.
BACKGROUND A recent cohort study suggested that intake of soy milk or soy formula was associated with peanut allergy . If this finding is confirmed , it suggests an avenue for modification of diet as a peanut allergy prevention strategy . OBJECTIVE To investigate the relationship between soy consumption and peanut sensitization in a prospect i ve cohort study of children . METHODS A total of 620 babies with a family history of allergic disease were recruited . Dietary information was obtained from telephone interviews every 4 weeks from birth until 15 months and then again at 18 months and 2 years . Skin prick tests to peanut , milk , and egg were performed at 6 , 12 , and 24 months . A wheal size > or = 3 mm was considered positive for sensitization . RESULTS Children whose parents elected to introduce soy formula or soy milk into their children 's diet were more likely to be sensitized to peanuts at 2 years ( odds ratio , 2.02 ; 95 % CI , 1.04 - 3.92 ; P = .039 ) . However , this relationship was explained by feeding of soy to children who had siblings with milk allergy or were themselves sensitized to milk . After adjusting for these factors , there was no evidence of an association between soy consumption and peanut sensitization ( odds ratio , 1.34 ; 95 % CI , 0.64 - 2.79 ; P = .434 ) . CONCLUSION The association between soy consumption and peanut sensitization is not causal but merely a result of preferential use of soy milk in infants with a personal or family history of cow 's milk allergy . Future studies should take the confounding effects related to dietary modifications by parents into account when investigating the association between diet and childhood allergic diseases
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .