A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .
Double-blind, placebo-controlled study of modafinil for fatigue and cognition in schizophrenia patients treated with psychotropic medications.
OBJECTIVE To assess the effects of modafinil on fatigue , symptoms , attention , working memory , and executive functioning in schizophrenia patients treated with psychotropic medications . METHOD Twenty-four patients with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder ( 10 men and 14 women ) were r and omly assigned to modafinil up to 200 mg a day ( N = 13 ) or placebo ( N = 11 ) as an adjunct therapy in an 8-week , double-blind , placebo-controlled study . Data were collected from May 18 , 2001 to September 11 , 2003 . RESULTS Four subjects terminated the study early , including one because of worsening of psychosis during the first week taking modafinil . In the modafinil ( N = 10 ) and placebo ( N = 10 ) groups , fatigue improved significantly over time ( p < .01 ) , but there were no differences between groups on changes in fatigue , positive and negative symptoms , or cognition . CONCLUSION Fatigue improved in both groups , and there were no differences between groups on changes in fatigue , symptoms , attention , working memory , or executive functioning . Lack of differences between groups may be due to small sample size or possible regression to the mean in the placebo group
A review of its effects in schizophrenia suggests that modafinil facilitates cognitive functions , with pro-mnemonic effects and problem solving improvements .
The systematic review on the neurochemical modulation of the modafinil suggests that its mnemonic enhancing properties might be the result of glutamatergic and dopaminergic increased neuronal activation in the hippocampus and in the prefrontal cortex respectively .
Other neurotransmitters were also activated by modafinil in various limbic brain areas , suggesting that the drug acts on these brain regions to influence emotional responses .
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping .
Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood .
Here , we review the effects of modafinil in human cognition and emotion and its specific actions on symptoms in patients with schizophrenia and whether these are consistently effective throughout the literature .
We also performed a systematic review on the effects of modafinil on neurotransmitter signalling in different areas of the brain in order to better underst and the neuromechanisms of its cognitive and emotional enhancing properties .