There was consistent evidence from cross-sectional data of an unfavourable association between total sedentary time and insulin sensitivity .
There was also some evidence that total sedentary time was unfavourably associated with fasting insulin , insulin resistance and triglycerides .
Furthermore , there was some evidence from cross-sectional data of a favourable association between breaks in sedentary time and triglycerides .
CONCLUSION Total sedentary time was consistently shown to be associated with poorer insulin sensitivity , even after adjusting for time spent in physical activity .
OBJECTIVE We conducted a systematic review to investigate the cross-sectional and prospect i ve associations of accelerometer-measured total sedentary time and breaks in sedentary time with individual cardiometabolic biomarkers in adults ≥18years of age .
Objectively Measured Moderate- and Vigorous-Intensity Physical Activity but Not Sedentary Time Predicts Insulin Resistance in High-Risk Individuals
OBJECTIVE Low levels of physical activity appear to be associated with insulin resistance . However , the detailed associations of these complex relationships remain elusive . We examined the prospect i ve associations between self-reported TV viewing time , objective ly measured time spent sedentary , at light-intensity activity , and at moderate- and vigorous-intensity physical activity ( MVPA ) with insulin resistance . RESEARCH DESIGN AND METHODS In 192 individuals ( 81 men and 111 women ) with a family history of type 2 diabetes , we measured  physical activity and anthropometric and metabolic variables at baseline and after 1 year of follow-up in the ProActive UK trial . Physical activity  was measured objective ly by accelerometry . Insulin resistance was expressed as fasting insulin and the homeostasis model assessment score ( HOMA-IR ) . RESULTS Baseline MVPA was a significant predictor of fasting insulin at follow-up ( β = −0.004 [ 95 % CI −0.007 to −0.0001 ] , P = 0.022 ) , and the association approached significance for HOMA-IR ( β = −0.003 [ −0.007 to 0.000002 ] , P = 0.052 ) , independent of time spent sedentary , at light-intensity activity , sex , age , smoking status , waist circumference , and self-reported TV viewing . Time spent sedentary and at light-intensity activity were not significantly associated with insulin resistance . The change in MVPA between baseline and follow-up was inversely related to fasting insulin ( β = −0.003 [ −0.007 to −0.0003 ] , P = 0.032 ) and the HOMA-IR score ( β = −0.004 [ −0.008 to −0.001 ] , P = 0.015 ) at follow-up , after adjustment for baseline phenotype in addition to the same confounders as above . CONCLUSIONS These results highlight the importance of promoting moderate-intensity activity such as brisk walking for improving insulin sensitivity and possibly other metabolic risk factors to prevent type 2 diabetes
There was consistent evidence from cross-sectional data of an unfavourable association between total sedentary time and insulin sensitivity .
There was also some evidence that total sedentary time was unfavourably associated with fasting insulin , insulin resistance and triglycerides .
Furthermore , there was some evidence from cross-sectional data of a favourable association between breaks in sedentary time and triglycerides .
CONCLUSION Total sedentary time was consistently shown to be associated with poorer insulin sensitivity , even after adjusting for time spent in physical activity .
OBJECTIVE We conducted a systematic review to investigate the cross-sectional and prospect i ve associations of accelerometer-measured total sedentary time and breaks in sedentary time with individual cardiometabolic biomarkers in adults ≥18years of age .