There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .
Comparison of efficacy and safety of two parenteral iron preparations in pregnant women
Objective : To compare the efficacy and safety with a fixed dose of two parenteral iron preparations , iron sucrose complex and iron sorbitol citric acid as per the current practice . Material s and Methods : A prospect i ve r and omized open label study was conducted . In this study , 60 pregnant women with hemoglobin less than 8.5 g/dl received a fixed dose of either IV iron sucrose or IM iron sorbitol citric acid therapy . The efficacy of the therapy was assessed by laboratory parameters such as hemoglobin , hematocrit , MCV , MCH , and serum ferritin level after 14 and 28 days . To assess the safety , adverse drug reactions with both the therapies were recorded . Results : Hemoglobin concentration increased significantly ( P < 0.001 ) with respect to time in both the groups . The rise in the hemoglobin level in third and fourth weeks was significantly higher in iron sucrose ( 0.92 g/dl ) than iron sorbitol citric acid therapy ( 0.56 g/dl ) . There was no significant change in the rise of the serum ferritin level after both the therapies . Adverse events were common with iron sorbitol citric acid therapy . However , no serious adverse drug reactions were observed . Conclusions : No significant difference in the efficacy of both of the therapy . However , adverse events and dropout rates were much more common in the group of pregnant women who received iron sorbitol citric acid
There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .