We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
Multifaceted allergen avoidance during infancy reduces asthma during childhood with the effect persisting until age 18 years
Background Asthma is a chronic disease that often starts in childhood . The key risk factors are a child 's environment and their genetic characteristics . The aim of this study was to evaluate the efficacy of environmental modification in the first 12 months of life on the prevalence of  asthma in high-risk individuals . Methods Children ( n=120 ) considered at high risk of allergic disorders ( either dual heredity or single heredity and a high cord total IgE ) , were enrolled in a single-blinded , r and omised controlled trial . Infants in the intervention arm were either breast fed with the mother on a low allergen diet or given an extensively hydrolysed formula . Exposure to house dust mite allergen was reduced . The control group followed st and ard advice .  Children were assessed at ages 1 , 2 , 4 , 8 and 18 years for the presence of asthma and atopy . Results At 18 years of age , there was a significantly lower prevalence of asthma in the prevention group compared with the control group ( OR : 0.23 , 95 % CI 0.08 to 0.70 , p=0.01 ) , primarily due to asthma that developed during childhood but persisted until age 18 years . Repeated-measure analysis showed that there was an overall reduction in asthma prevalence from 1 to 18 years ( OR : 0.51 , CI 0.32 to 0.81 , p=0.04 ) . Prevalence of atopy was not significantly different between the two groups at age 18 . Conclusion Comprehensive allergen avoidance in the first year of life is effective in preventing asthma onset in individuals considered at high risk due to heredity . The effect occurs in the early years , but persists through to adulthood
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .