There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Erythrocyte fatty acid composition in term infants fed human milk or a formula enriched with a low eicosapentanoic acid fish oil for 4 months
Abstract When term infants are fed st and ard formula that does not contain long-chain polyunsaturated fatty acids ( LC-PUFA ) , they still show lower levels of docosahexaenoic acid ( DHA ) in red blood cell ( RBC ) phospholipids by several weeks or months postnatally . This study was design ed in order to evaluate a potential alternative for supplementing term infant formulas with DHA by adding a high-DHA/low-eicosapentanoic acid fish oil to levels similar to that in human milk ( 0.3 % ) . A total of 37 term infants were included in the study at 3 days of life .  DHA concentrations remained stable between inclusion and 4 months of life at around 8 % of the RBC phospholipids in the LC-PUFA enriched formula-fed group whereas it decreased significantly in the st and ard formula-fed group . In the human milk-fed group , RBC DHA concentrations at 4 months of age were significantly lower than that at birth and were significantly correlated with the duration of breast feeding ( r = 0.85 ; P = 0.0002 ) . A significant decrease of arachidonic acid between inclusion and 4 months of age was observed in the enriched formula-fed group and reached a mean value at 4 months , which was significantly lower than that observed in the human milk or st and ard formula-fed groups ( P < 0.0001 ) . Conclusion Supplementing term formulas with a high-docosahexaenoic acid/low-eicosapentanoic acid fish oil up to 4 months of age is efficient in improving docosahexaenoic acid status , however it increases the risk of impaired n-6 fatty acid status
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .