Widespread use of fluoroquinolone prophylaxis may be associated with an increase in resistant Escherichia coli strains , posing a potentially major health issue in the future .
INTRODUCTION Transrectal ultrasound-guided biopsies ( TRUS-gb ) are associated with both mild and serious complications .
Prophylactic antibiotics reduce the risk of septicaemia and mortality ; however , no international consensus exists on the timing and duration of antibiotics , including the optimal drug strategy .
We review ed the current evidence supporting use of prophylactic antibiotics and the risk of complications following prostate biopsies .
Antibiotic prophylaxis for transrectal prostate biopsy: a prospective randomized study of tosufloxacin versus levofloxacin.
OBJECTIVES To assess the efficacy of tosufloxacin as a prophylactic agent for transrectal biopsy of the prostate ( TBP ) , we conducted a r and omized prospect i ve study comparing tosufloxacin versus levofloxacin . METHODS A r and omized prospect i ve study comparing tosufloxacin versus levofloxacin was performed . In group A , 124 patients received 300 mg tosufloxacin tosilate ( including 204 mg tosufloxacin ) twice daily for 2 days , with the initial dose being 2 h prior to biopsy . In group B , 119 patients received 200 mg levofloxacin in the same manner . RESULTS Infectious complications were reported equally in six cases in each group ( 4.8 % in group A and 5.0 % in group B ) . Each group included five cases of acute prostatitis and one of cystitis . Six patients suffering from prostatitis required hospitalization , while those with symptomatic urinary tract infection were treated as out patients . CONCLUSIONS Tosufloxacin was as effective as levofloxacin when administered twice daily for 2 days as prophylaxis for TBP , which suggests that this regimen is useful for reducing the clinical and febrile infection rate following TBP
Widespread use of fluoroquinolone prophylaxis may be associated with an increase in resistant Escherichia coli strains , posing a potentially major health issue in the future .
INTRODUCTION Transrectal ultrasound-guided biopsies ( TRUS-gb ) are associated with both mild and serious complications .
Prophylactic antibiotics reduce the risk of septicaemia and mortality ; however , no international consensus exists on the timing and duration of antibiotics , including the optimal drug strategy .
We review ed the current evidence supporting use of prophylactic antibiotics and the risk of complications following prostate biopsies .