Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Randomized clinical trial to comparing efficacy of daily, weekly and monthly administration of vitamin D3
The comparative efficacy and safety profiles of selected daily 1000 IU , weekly 7000 IU and monthly 30,000 IU vitamin D3—not previously investigated — will be evaluated . Here , a prospect i ve , r and omized clinical trial , comparing efficacy and safety of a daily single dose of 1000 IU ( group A ) to a once-weekly 7000 IU dose ( group B ) , or monthly 30,000 IU dose ( group C ) of vitamin D3 . The present study is a controlled , r and omized , open-label , multicenter clinical trial , 3 months in duration . Sixty-four adult subjects with vitamin D deficiency ( 25OHD<20 ng/ml ) , were included according to the inclusion and exclusion criteria . Dose-responses for increases in serum vitamin 25OHD were statistically equivalent for each of the three groups : A , B and C. Outcomes were 13.0 ± 1.5 ; 12.6 ± 1.1 and 12.9 ± 0.9 ng/ml increases in serum 25OHD per 1000 IU , daily , weekly and monthly , respectively . The treatment of subjects with selected doses restored 25OHD values to levels above 20 ng/ml in all groups . Treatment with distinct administration frequency of vitamin D3 did not exhibit any differences in safety parameters . The daily , weekly and monthly administrations of daily equivalent of 1000 IU of vitamin D3 provide equal efficacy and safety profiles
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .