Exercise , particularly aerobic exercise , had a significant effect on serum leptin and a possible influence on adiponectin levels , suggesting its therapeutic implication
Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals ; however , results to date are controversial .
Here we performed a systematic review and meta- analysis of the available r and omized controlled trials ( RCTs ) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals .
Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?
OBJECTIVE : To determine the effect of weight loss and exercise interventions on serum leptin and to investigate the relationship of physical function and osteoarthritis ( OA ) severity with serum leptin in older overweight and obese adults with knee OA . In addition , the study examined if serum leptin predicts weight loss . DESIGN : Longitudinal , controlled clinical trial of weight loss and exercise interventions .SUBJECTS : Community dwelling , older , overweight and obese adults ( n=316 ; > 60 years of age ; body mass index ≥28.0 kg m−2 ) with symptomatic knee OA and self-reported difficulty in performing selected physical activities were recruited . INTERVENTIONS : Participants were r and omized into one of four groups for the 18-month study duration : Healthy Lifestyle Controls , Dietary Weight Loss ( Diet ) , Exercise Training ( Exercise ) , and a combination of Dietary Weight Loss and Exercise Training ( Diet+Exercise ) . The weight loss goal for the two Diet groups was 5 % from baseline at 18 months . Participants in the Exercise groups were trained for 3 days week−1 , 60 min day−1 . MEASUREMENTS : Body weight , body mass index , serum leptin , physical function , and OA severity were measured at baseline , 6 months , and 18 months . RESULTS : Diet and Diet+Exercise groups lost 5.3 and 6.1 % of their weight , respectively , at 18 months with the Exercise group losing 2.9 % . There was a significant main effect of weight loss on serum leptin with a decrease in serum leptin averaged across the 6- and 18-month time points for the Diet and Diet+Exercise groups compared to the other two groups ( β=0.245 ; P<0.01 ) . No main effect  for exercise training was observed . Serum leptin was related to self-reported physical function . In all participants , a mixed model analysis demonstrated that lower levels of baseline serum leptin predict larger weight loss ( β=−2.779 ; P=0.048 ) . CONCLUSION : Decreases in serum leptin may be one mechanism by which weight loss improves physical function and symptoms in OA patients
Exercise , particularly aerobic exercise , had a significant effect on serum leptin and a possible influence on adiponectin levels , suggesting its therapeutic implication
Previous reports have shown that exercise improves serum leptin and adiponectin abnormalities in overweight and obese individuals ; however , results to date are controversial .
Here we performed a systematic review and meta- analysis of the available r and omized controlled trials ( RCTs ) of the possible beneficial action of exercise on serum leptin and adiponectin levels in overweight and obese individuals .