In conclusion , statins were effective in preventing postoperative adhesion , as assessed based on gross and microscopic adhesion scores in rats
Adhesion is a significant concern after surgery .
Many research ers studied the anti-adhesive effect of statin , of which results were inconsistent .
Thus , we purpose d to perform a systematic review and meta- analysis to evaluate the effect of statins on postoperative adhesion in an experimental study .
Metformin and atorvastatin reduce adhesion formation in a rat uterine horn model.
The aim of the present study was to determine whether atorvastatin and metformin are effective in preventing adhesions in a rat uterine horn model . A total of 40 non-pregnant , female Wistar albino rats , weighing 180 - 210 g , were used as a model for post-operative adhesion formation . The rats were r and omized into four groups after seven st and ard lesions were inflicted in each uterine horn and lower abdominal sidewall using bipolar cauterization . The rats were given atorvastatin 2.5 mg/kg/day , p.o . ( 10 rats ) , atorvastatin 30 mg/kg/day , p.o . ( 10 rats ) , metformin 50 mg/kg/day , p.o . ( 10 rats ) and no treatment was applied in the control group ( 10 rats ) . The animals were killed 2 weeks later and adhesions were scored both clinical ly and pathologically by authors blinded to groups . One rat in the control group died before the end of the 2 week period . Total clinical adhesion scores regarding extent , severity and degree of adhesions and histopathological findings including inflammation and fibrosis were significantly lower in the metformin ( P < 0.001 and P < 0.01 , respectively ) and atorvastatin 30 mg/kg/day ( P < 0.001 and P < 0.01 , respectively ) groups when compared with control group . Metformin and atorvastatin are both effective for prevention of adhesion formation in a rat uterine horn model
In conclusion , statins were effective in preventing postoperative adhesion , as assessed based on gross and microscopic adhesion scores in rats
Adhesion is a significant concern after surgery .
Many research ers studied the anti-adhesive effect of statin , of which results were inconsistent .
Thus , we purpose d to perform a systematic review and meta- analysis to evaluate the effect of statins on postoperative adhesion in an experimental study .