However , in patients with IBD flares and inadequate responses to or side effects with oral preparations , intravenous iron supplementation is the therapy of choice .
Neither oral nor intravenous therapy seems to exacerbate the clinical course of IBD , and intravenous iron therapy can be administered even in active disease stages and concomitantly with biologics .
Based on the data presented , oral iron therapy should be preferred for patients with quiescent disease stages and trivial iron deficiency  anemia unless such patients are intolerant or have an inadequate response , whereas intravenous iron supplementation may be of advantage in patients with aggravated anemia or flares of IBD because inflammation hampers intestinal absorption of iron
Abstract Anemia is the most frequent complication of inflammatory bowel disease ( IBD ) , but anemia , mostly due to iron deficiency , has long been neglected in these patients .
The aim was to briefly present the pathophysiology , followed by a balanced overview of the different forms of iron replacement available , and subsequently , to perform a systematic review of studies performed in the last decade on the treatment of iron-deficiency anemia in IBD .
The safety of intravenous iron dextran in hemodialysis patients.
The treatment of anemia in hemodialysis patients is frequently hindered by the presence of suboptimal iron stores . Intravenous iron dextran is in common use to maintain iron stores in this population , but there are little published data regarding the incidence and type of adverse events . The purpose of this study was to evaluate the safety of this medication . Charts from four hemodialysis centers of all 573 patients treated with intravenous iron dextran ( INFeD ; Schein Pharmaceutical , Inc , Florham Park , NJ ) between July 1 , 1993 , and June 30 , 1995 , were studied . Twenty-seven patients ( 4.7 % ) had adverse reactions that were related to iron dextran . Four patients ( 0.7 % ) had reactions classified as serious ( one cardiac arrest ; three others required hospitalization ) . Ten patients ( 1.7 % ) had reactions classified as anaphylactoid . No patients died or developed permanent disability as a result of reactions . The most common adverse reactions included itching ( 1.5 % of patients ) and dyspnea or wheezing ( 1.5 % ) ; others included chest pain ( 1.0 % ) , nausea ( 0.5 % ) , hypotension ( 0.5 % ) , swelling ( 0.5 % ) , dyspepsia ( 0.5 % ) , diarrhea ( 0.5 % ) , skin flushing ( 0.3 % ) , headache ( 0.3 % ) , cardiac arrest ( 0.2 % ) , and myalgias ( 0.2 % ) . Five of all the reactions occurred during a test dose ; four of these were anaphylactoid . Several factors were studied as possible predictors of adverse reactions . A positive history of drug allergy ( odds ratio , 2.4 ; P = 0.03 ) and history of multiple drug allergy ( odds ratio , 5.5 ; P = 0.0004 ) were significant predictors of reactions . In summary , we found serious adverse reactions to be uncommon in hemodialysis patients treated with intravenous iron dextran .  Future prospect i ve studies will help confirm this finding
However , in patients with IBD flares and inadequate responses to or side effects with oral preparations , intravenous iron supplementation is the therapy of choice .
Neither oral nor intravenous therapy seems to exacerbate the clinical course of IBD , and intravenous iron therapy can be administered even in active disease stages and concomitantly with biologics .
Based on the data presented , oral iron therapy should be preferred for patients with quiescent disease stages and trivial iron deficiency  anemia unless such patients are intolerant or have an inadequate response , whereas intravenous iron supplementation may be of advantage in patients with aggravated anemia or flares of IBD because inflammation hampers intestinal absorption of iron
Abstract Anemia is the most frequent complication of inflammatory bowel disease ( IBD ) , but anemia , mostly due to iron deficiency , has long been neglected in these patients .
The aim was to briefly present the pathophysiology , followed by a balanced overview of the different forms of iron replacement available , and subsequently , to perform a systematic review of studies performed in the last decade on the treatment of iron-deficiency anemia in IBD .