REVIEW ER 'S CONCLUSIONS We found no significant evidence to support the use of clotiapine rather than other ' st and ard ' or ' non-st and ard ' treatments for the management of  acute psychotic illness .
BACKGROUND Acute psychotic illness , especially when associated with agitated or violent behaviour , requires urgent pharmacological tranquillisation or sedation .
Clotiapine , a dibenzothiazepine neuroleptic , is being used for this purpose in several countries .
OBJECTIVES To estimate the effects of clotiapine when compared to other ' st and ard ' or ' non-st and ard ' treatments of acute psychotic illness in controlling disturbed behaviour and reducing psychotic symptoms .
Chlorpromazine, clotiapine and thioridazine--a comparative clinical trial on Bantu psychotic patients.
In a non-blind assessment of 3 neuroleptic drugs  , chlorpromazine ( Largactil ) , thioridazine ( Melleril ) and clotiapine ( Etomine ) , we found Etomine to be the drug of choice when the diagnosis is in doubt between a toxic psychosis or schizophrenia . This drug also offered the highest discharge rate , 77'7 % at 12 weeks compared with 73'5 % in the thioridazine group , and 55'5 % in the chlorpromazine group . No clouding of consciousness was seen in the clotiapine group , whereas it was troublesome in the chlorpromazine group in patients having received high parenteral doses
REVIEW ER 'S CONCLUSIONS We found no significant evidence to support the use of clotiapine rather than other ' st and ard ' or ' non-st and ard ' treatments for the management of  acute psychotic illness .
BACKGROUND Acute psychotic illness , especially when associated with agitated or violent behaviour , requires urgent pharmacological tranquillisation or sedation .
Clotiapine , a dibenzothiazepine neuroleptic , is being used for this purpose in several countries .
OBJECTIVES To estimate the effects of clotiapine when compared to other ' st and ard ' or ' non-st and ard ' treatments of acute psychotic illness in controlling disturbed behaviour and reducing psychotic symptoms .