The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
Chemotherapeutic inhibition of supragingival dental plaque and gingivitis development.
A 6-month double-blind , controlled clinical study was conducted on 107 healthy adult subjects to determine the efficacy of a mouthrinse used as a supplement to regular oral hygiene measures on supragingival dental plaque and gingivitis . 115 healthy adult patients were recruited for the study . Following screening examinations for minimal entry levels of existing gingivitis and plaque in patients with a minimum of 20 sound natural teeth , extrinsic tooth stain , gingivitis and plaque index scores were recorded . Soft tissues were evaluated . All subjects then received a complete dental prophylaxis , removing plaque , calculus and extrinsic stain . Utilizing their normal oral hygiene , subjects began a regimen of rinsing with 20 ml of the r and omly assigned rinse , twice daily for 30 s for 6 months . 7 days after prophylaxis , gingivitis was again scored ( baseline 2 ) . Soft tissue , gingivitis , plaque area and extrinsic stain were evaluated again at 3 and 6 months . Results demonstrated that after 6 months , listerine produced a 34 % inhibition of both plaque and of gingivitis compared to a hydroalcohol control ( p less than 0.001 )
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .