Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .
Treatment of Peyronie's disease with intralesional verapamil injection.
PURPOSE In a previous study , 83 % of 14 patients noted that their symptoms of Peyronie 's disease had arrested or improved after intralesional injection of verapamil . This nonr and omized , prospect i ve study further investigates the use of verapamil in a larger , thoroughly characterized patient population . MATERIAL S AND METHODS Forty-six men began treatment ; 38 completed the study . Using a multiple puncture technique , 10 mg . of verapamil diluted to 10 cc were distributed throughout the plaque every 2 weeks for a total of 12 injections . Response to treatment was evaluated through subjective and objective measurements of pain , plaque size , deformity , duration of disease and sexual function , and with the Kelami classification system based on plaque size and curvature . RESULTS Pain resolved in 97 % of the patients who presented with pain after a mean of 2.5 injections . After therapy , 76 % reported a subjective decrease in curvature , 9.5 % noted an increase and 14.5 % remained unchanged . Of the treated patients 72 % reported an improvement in the ability to engage in coitus . Objective measurements demonstrated that curvature was decreased in 54 % of the patients , increased in 11 % and remained unchanged in 34 % . There were no substantial differences in response to treatment based on duration of disease or within the 3 Kelami classification groups . Other than transient post-injection ecchymosis , there were no significant acute or chronic side effects . CONCLUSIONS Verapamil injection therapy result ed in a reduction of pain in 97 % of the patients , an improvement in sexual function in 72 % , a reduction of deformity in 86 % , an improvement in distal rigidity in 93 % and an objective reduction of curvature in 54 % . Further studies are required to determine the effectiveness of this nontoxic , inexpensive , nonsurgical approach to Peyronie 's disease
Qualitative data from these studies suggest a clinical ly significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length .
Verapamil and HA performed well in single-arm or case-control studies .
Studies of penile traction and vacuum devices in patients with PD demonstrated some benefits in terms of curvature and penile length but only in small , underpowered , nonr and omised studies .
Studies of onabotulinum toxin A injections or thiocolchicine showed significant improvements in penile curvature , but only in studies of single-arm or case-control design .
CONCLUSIONS CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature ; CCH can also improve penile length .
However , based on available data , strong conclusions can not be drawn for other treatments , including calcium channel blockers , HA , or mechanical therapies .
PATIENT SUMMARY Our systematic review of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie 's disease .
No robust evidence is available to support the use of other local treatments including calcium channel blockers , hyaluronic acid , or mechanical therapies
CONTEXT Conservative therapies for Peyronie 's disease ( PD ) aim to treat early-stage disease by improving clinical outcomes such as penile curvature , penile length erectile dysfunction , and pain .
OBJECTIVE To summarise the available evidence regarding injection and mechanical therapies for PD treatment .