Conclusion Our results indicate  that L-carnitine  reduced inflammatory mediators , especially in studies with a duration of more than 12 weeks .
Aim and background Reducing inflammation by nutritional supplements may help to reduce the risk of many chronic diseases .
Our aim in this meta- analysis was to determine the effect of L-carnitine on inflammatory mediators including C-reactive protein ( CRP ) , tumor necrosis factor-α ( TNF-α ) , and interleukin-6 ( IL-6 ) .
Randomized Trial of Carnitine for the Prevention of Perioperative Atrial Fibrillation.
Atrial  fibrillation ( AF )  is one of the most common complications in patients who undergo coronary artery bypass graft surgery ( CABG ) . The aim of this study was to evaluate the effect of L-carnitine administration on postoperative AF and the levels of C-reactive protein ( CRP ) following CABG . The effects of L-carnitine on the incidence of acute kidney injury after CABG were also assessed . One hundred thirty-four patients undergoing elective CABG , without a history of AF or previous L-carnitine treatment , were r and omly assigned to an L-carnitine group ( 3000 mg/d L-carnitine ) or a control group .  CRP levels , as a biomarker of inflammation , were assessed in all the patients before surgery as baseline levels and 48 hours postoperatively . Neutrophil gelatinase-associated lipocalin , as a kidney biomarker , was also measured in the patients before surgery and 2 hours thereafter . The incidence of AF was 13.4 % in our population . The incidence of AF was decreased in the L-carnitine group ( 7.5 % in the L-carnitine group vs 19.4 % in the control group ; P = 0.043 ) and the postoperative CRP level ( 8.79 ± 6.9 in the L-carnitine group , and 10.83 ± 5.7 in the control group ; P = 0.021 ) . The postoperative neutrophil gelatinase-associated lipocalin concentration demonstrated no significant rise after surgery compared with the preoperative concentration ( 72.54 ± 20.30 in the L-carnitine group vs 67.68 ± 22.71 in the placebo group ; P = 0.19 ) . Our study showed that L-carnitine administration before CABG might inhibit and reduce the incidence of AF after CABG . It seems that a rise in the CRP level , as an inflammation marker , may be associated with the incidence of AF . Inflammation as measured by CRP was also reduced in the carnitine group , compared with the control group
Conclusion Our results indicate  that L-carnitine  reduced inflammatory mediators , especially in studies with a duration of more than 12 weeks .
Aim and background Reducing inflammation by nutritional supplements may help to reduce the risk of many chronic diseases .
Our aim in this meta- analysis was to determine the effect of L-carnitine on inflammatory mediators including C-reactive protein ( CRP ) , tumor necrosis factor-α ( TNF-α ) , and interleukin-6 ( IL-6 ) .