On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Comparison of the effects of chlorpromazine, dextroamphetamine and methylphenidate on the behaviour and intellectual functioning of hyperactive children.
Chlorpromazine , dextroamphetamine and methylpheni date were significantly superior to placebo in producing overall improvement in the behaviour of hyperactive children .  Chlorpromazine was effective for the majority of the children , but reduced only hyperactivity , having no demonstrable effect on distractibility , aggressivity or excitability . Both stimulants produced more goal -oriented behaviour and reduced distractibility .  Methylpheni date was the most effective of the drugs in prpducing exceptional improvement . All three active drugs had to be discontinued in a few of the children because of side effects . Not all hyperactive children were benefited by the drugs . No background variables ( with the exception of mother-child relationship ) were found in the present studies to predict favourable response to the drugs . Methylpheni date became our drug of choice for this group of hyperactive children
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .