Depression frequently causes unemployment , absenteeism , and presenteeism , which results in significantly reduced productivity .
Improving patients ' compliance with their antidepressant medication results in improved outcomes and prolongs remission from depression , increasing work productivity , and thus reducing overall costs .
The implementation of remote enhanced-care programs may improve compliance and reduce overall costs .
In conclusion , depression is a common disorder with a high economic impact .
Enhanced-care programs may lower costs associated with depression and improve patients ' lives
This systematic review examines the economic and human costs of depression and the potential savings associated with improvement in patient adherence to treatment with antidepressants through the use of enhanced-care programs .
Impact of an antidepressant management program on medication adherence.
OBJECTIVE To evaluate the impact of mail-based physician and member educational interventions on  patient adherence  to antidepressant medications . STUDY DESIGN The r and omized controlled prospect i ve design included patients followed for 6 months after filling a new prescription for an antidepressant . A pharmacy cl aims data base was used to identify patients and track medication adherence . PATIENTS AND METHODS Patients receiving a new prescription for an antidepressant and their prescribers were included . Prescribers were r and omly assigned to the intervention and control groups . Patient assignment was linked to their physician 's assignment . The control group received no intervention . The educational intervention consisted of monthly letters to patients and prescribers regarding the Health Plan Employer Data and Information Set ( HEDIS ) st and ards or educational information regarding the importance of medication adherence . The primary outcome was adherence as measured by the medication possession ratio and measurement as specified by HEDIS . The Student 's ttest , the chi2 test , and a logistic regression model were used to compare groups and the variables that affect adherence . Other secondary measurements of adherence were performed . RESULTS A total of 9564 patients were included . Patients in the intervention group demonstrated greater adherence compared with the control group at 90 and 180 days ( P < .05 ) . After adjusting for variables , the intervention variable stood alone in its significant impact on adherence ( P < .01 ; confidence interval , 1.003 - 1.197 ) . Adherence in the total population was significantly higher for selective serotonin reuptake inhibitors than for other agents ( P < .001 ) . CONCLUSION A monthly mail-based educational intervention program regarding antidepressant medications can positively influence patient adherence to therapy
Depression frequently causes unemployment , absenteeism , and presenteeism , which results in significantly reduced productivity .
Improving patients ' compliance with their antidepressant medication results in improved outcomes and prolongs remission from depression , increasing work productivity , and thus reducing overall costs .
The implementation of remote enhanced-care programs may improve compliance and reduce overall costs .
In conclusion , depression is a common disorder with a high economic impact .
Enhanced-care programs may lower costs associated with depression and improve patients ' lives
This systematic review examines the economic and human costs of depression and the potential savings associated with improvement in patient adherence to treatment with antidepressants through the use of enhanced-care programs .