Conclusion Our results indicate  that L-carnitine  reduced inflammatory mediators , especially in studies with a duration of more than 12 weeks .
Aim and background Reducing inflammation by nutritional supplements may help to reduce the risk of many chronic diseases .
Our aim in this meta- analysis was to determine the effect of L-carnitine on inflammatory mediators including C-reactive protein ( CRP ) , tumor necrosis factor-α ( TNF-α ) , and interleukin-6 ( IL-6 ) .
Effects of L-carnitine supplement on serum inflammatory cytokines, C-reactive protein, lipoprotein (a), and oxidative stress in hemodialysis patients with Lp (a) hyperlipoproteinemia.
Inflammation , oxidative stress , and high concentration of serum lipoprotein ( a ) [ Lp ( a ) ] are common complications in hemodialysis patients . The present study was design ed to investigate the effects of L-carnitine supplement on serum inflammatory cytokines , C-reactive protein ( CRP ) , Lp ( a ) , and oxidative stress in hemodialysis patients with Lp ( a ) hyperlipoproteinemia [ hyper Lp ( a ) ] . This was an unblinded , r and omized clinical trial . Thirty-six hyper Lp ( a ) hemodialysis patients ( 23 men and 13 women ) were r and omly assigned to either a carnitine or control group . Patients in the carnitine group received 1000 mg/d oral L-carnitine for 12 weeks , whereas patients in the control group did not receive any L-carnitine supplement . At baseline and the end of week 12 , 5 mL of blood were collected after a 12- to 14-hours fast and serum free carnitine , CRP , interleukin-1β , interleukin-6 ( IL-6 ) , tumor necrosis factor-α , Lp ( a ) , and oxidized low-density lipoprotein were measured . Serum free carnitine concentration increased significantly by 86 % in the carnitine group at the end of week 12 compared with baseline ( P<0.001 ) , while serum CRP and IL-6 showed a significant decrease of 29 % ( P<0.05 ) and 61 % ( P<0.001 ) , respectively . No significant changes were observed in serum free carnitine , CRP , and IL-6 in the control group . There were no significant differences between the two groups in mean changes of serum interleukin-1β , tumor necrosis factor-α , Lp ( a ) , and oxidized low-density lipoprotein concentrations . L-carnitine supplement  reduces inflammation in hemodialysis patients , but has no effect on hyper Lp ( a ) and oxidative stress
Conclusion Our results indicate  that L-carnitine  reduced inflammatory mediators , especially in studies with a duration of more than 12 weeks .
Aim and background Reducing inflammation by nutritional supplements may help to reduce the risk of many chronic diseases .
Our aim in this meta- analysis was to determine the effect of L-carnitine on inflammatory mediators including C-reactive protein ( CRP ) , tumor necrosis factor-α ( TNF-α ) , and interleukin-6 ( IL-6 ) .