The associations between BP-lowering treatments and outcomes were not significantly different , irrespective of drug class , except for stroke and heart failure .
AND RELEVANCE Among patients with type 2 diabetes , BP lowering was associated with improved mortality and other clinical outcomes with lower RRs observed among those with baseline BP of 140 mm Hg and greater .
These findings support the use of medications for BP lowering in these patients
IMPORTANCE Lowering blood pressure ( BP ) is widely used to reduce vascular risk in individuals with diabetes .
OBJECTIVE To determine the associations between BP-lowering treatment and vascular disease in type 2 diabetes .
Five-year findings of the Hypertension Detection and Follow-up Program
The Hypertension Detection and Follow-up Program ( HDFP ) data are reported by diastolic blood pressure ( DBP ) stratum for four race-sex subgroups . For Stratum I ( entry DBP 90–104 mm Hg ) in each of the race-sex subgroups ( black male , black female , white male , and white female ) , Stepped Care ( SC ) participants experienced a reduced mortality as compared to Referred Care ( RC ) . For black males and females in all three entry DBP strata , mortality was lower in the SC than RC . Only in three subgroups did the SC mortality exceed RC : Stratum II ( entry DBP 105–114 mm Hg ) white females and Stratum III ( entry DBP 115 + mm Hg ) white males and females . Possible explanations for these deviant findings are discussed . The HDFP was design ed to determine the difference in total 5-year mortality between SC and RC ; subgroup analyses may be subject to large chance variation and must be interpreted with great caution . The value of vigorous treatment of “ mild ” hypertension ( Stratum I ) in males and females , black and white , and the value of treatment for all blood pressure strata in blacks are confirmed by this analysis
The associations between BP-lowering treatments and outcomes were not significantly different , irrespective of drug class , except for stroke and heart failure .
AND RELEVANCE Among patients with type 2 diabetes , BP lowering was associated with improved mortality and other clinical outcomes with lower RRs observed among those with baseline BP of 140 mm Hg and greater .
These findings support the use of medications for BP lowering in these patients
IMPORTANCE Lowering blood pressure ( BP ) is widely used to reduce vascular risk in individuals with diabetes .
OBJECTIVE To determine the associations between BP-lowering treatment and vascular disease in type 2 diabetes .