In summary , the current meta- analysis demonstrated that melatonin supplementation  significantly decreased SBP and DBP in patients with metabolic disorders .
The current systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to evaluate the potential effect of melatonin supplementation on  blood pressure in patients with metabolic disorders .
Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men.
In this study it was investigated whether the oral administration of melatonin ( 1 mg ) in comparison to placebo was able to reduce blood pressure , vascular reactivity , and catecholamines  in men , as previously reported in young women . The administration of melatonin significantly reduced blood pressure , the pulsatility index in the internal carotid artery , and catecholamines levels within 90 minutes . The effect of melatonin on the artery pulsatility index was related to baseline values , being greater in men with higher baseline values . The present data indicate that melatonin may blunt the activity of the cardiovascular system and may have both physiopathologic and clinical implication
In summary , the current meta- analysis demonstrated that melatonin supplementation  significantly decreased SBP and DBP in patients with metabolic disorders .
The current systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to evaluate the potential effect of melatonin supplementation on  blood pressure in patients with metabolic disorders .