Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .
Effects of testosterone on mood, aggression, and sexual behavior in young men: a double-blind, placebo-controlled, cross-over study.
The prospect s of wider application of testosterone ( T ) in novel indications such as male contraception have prompted renewed interest in the investigation of nonreproductive actions and safety of and rogens . This study investigated potential changes in mood and behavior in response to elevations in circulating T concentrations produced by the new long-acting preparation , T undecanoate ( TU ) .  Twenty-eight eugonadal men were r and omized into one of two treatment groups : A1 ) active , receiving 1000 mg TU i.m . followed by A2 ) washout , followed by A3 ) placebo , receiving 4 ml castor oil i.m . ; B1 ) placebo , 4 ml castor oil i.m . ; B2 ) washout followed by B3 ) active , receiving 1000 mg TU i.m .. Mood , self- and partner-reported physical and verbal aggression , anger , hostility , irritability , assertiveness , self-esteem , and sexual function were assessed . A single injection of 1000 mg TU i.m . increased plasma T concentrations from 20.7 + /- 1.5 to 37.5 + /- 2.2 nmol/liter at wk 1 and 31.6 + /- 1.5 nmol/liter at wk 2 , and estradiol from 74.0 + /- 4.9 to 120.4 + /- 10.7 pmol/liter at wk 1 , and 100.0 + /- 6.3 pmol/liter at wk 2 . The T increment was associated with detectable but minor mood changes . Increased circulating T was associated with significant increases in anger-hostility from baseline ( mean score = 7.48 ) to wk 2 ( mean score = 10.71 ) accompanied by an overall reduction in fatigue-inertia ( treatment = 6.21 vs. placebo = 7.84 ) . TU treatment did not increase aggressive behavior or induce any changes in nonaggressive or sexual behavior . Changes in estradiol were not associated with any behavioral alterations . Our results suggest that exogenous TU-induced elevation of circulating T , to the range likely to be used in hormonal male contraception , has limited psychological effects . Future research should investigate the implication s of these minor mood changes
Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .