The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Once-daily treatment of patients with hypertension: a placebo-controlled study of amlodipine and benazepril vs amlodipine or benazepril alone
Objective : To compare the efficacy , tolerability , and safety of once-daily therapy with amlodipine 5 mg/benazepril 10 mg vs amlodipine 5 mg , benazepril 10 mg , and placebo . Design : R and omised , double-blind , placebo-controlled , parallel-group , multicentre trial . Setting : Twenty-two clinical centres , including private practice groups and academic research clinics . Patients : A total of 530 patients between 21 and 80 years of age with essential hypertension were screened for the study , and 454 were r and omised to treatment with amlodipine 5 mg/benazepril 10 mg , amlodipine 5 mg , benazepril 10 mg , or placebo for 8 weeks . Results : Amlodipine 5 mg/benazepril 10 mg produced greater reductions from baseline in sitting diastolic blood pressure than amlodipine 5 mg ( P < 0.03 ) , benazepril 10 mg ( P < 0.001 ) , and placebo ( P < 0.001 ) . The response rate in the amlodipine 5-mg/benazepril 10-mg treatment group ( 66.4 % ) was better than that observed in the amlodipine 5-mg ( 50.0 % P < 0.02 ) , benazepril 10-mg ( 38.3 % P < 0.001 ) , and placebo ( 24.4 % P < 0.001 ) groups . There was no significant difference in heart rate among the four groups . The incidence of oedema in the amlodipine 5-mg/benazepril 10-mg ( 1.7 % ) group was somewhat less than that in the amlodipine 5-mg ( 4.5 % ) group . Conclusions : Therapy with amlodipine 5 mg/benazepril 10 mg was well tolerated and was superior to amlodipine 5 mg , benazepril 10 mg , and placebo in reducing sitting diastolic blood pressure in patients with essential hypertension
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .