REVIEW ER 'S CONCLUSIONS It remains unclear whether antihypertensive drug therapy for mild-moderate hypertension during pregnancy is worthwhile
BACKGROUND Mild-moderate hypertension during pregnancy is common .
Antihypertensive drugs are often used in the belief that lowering blood pressure will prevent progression to more severe disease , and thereby improve outcome .
OBJECTIVES To assess the effects of antihypertensive drug treatments for women with mild to moderate hypertension during pregnancy .
The effect of sublingual nifedipine on uteroplacental blood flow in hypertensive pregnancy
Summary . The effect of nifedipine on uteroplacental blood flow was investigated in nine hypertensive women in the third trimester of pregnancy and compared with the effects of a placebo in nine similar hypertensive women . An index of uteroplacental blood flow was obtained , twice before treatment and once after treatment , by measuring the increase in radioactivity in the region of the placenta with a gamma camera following an intravenous injection of indium‐113 m . There was no significant change in the blood flow index in either the nifedipine‐ or the placebo‐treated groups despite a significant fall in blood pressure with nifedipine . Nifedipine lowers the blood pressure without any apparent reduction in uteroplacental blood flow
REVIEW ER 'S CONCLUSIONS It remains unclear whether antihypertensive drug therapy for mild-moderate hypertension during pregnancy is worthwhile
BACKGROUND Mild-moderate hypertension during pregnancy is common .
Antihypertensive drugs are often used in the belief that lowering blood pressure will prevent progression to more severe disease , and thereby improve outcome .
OBJECTIVES To assess the effects of antihypertensive drug treatments for women with mild to moderate hypertension during pregnancy .