The results show that , in particular , frequent cannabis use , especially daily use , and the consumption of high-potency cannabis are associated with a higher risk of developing psychosis .
Moreover , several genotypes moderate the impact of cannabis use on psychosis risk , particularly those involved in the dopamine function , such as AKT1 .
Finally , cannabis use is associated with an earlier psychosis onset and increased risk of transition in individuals at a clinical high risk of psychosis .
These findings indicate that changing cannabis use behavior could be a harm reduction strategy employed to lower the risk of developing psychosis .
Increasing evidence indicates a relationship between  cannabis use and psychosis risk .
Specific factors , such as determinants of cannabis use or the genetic profile of cannabis users , appear to moderate this association .
The present systematic review presents a detailed and up-to- date literature overview on factors that influence the relationship between cannabis use and psychosis risk .
Age‐varying effects of cannabis use frequency and disorder on symptoms of psychosis, depression and anxiety in adolescents and adults
Abstract Aims We tested the age‐varying associations of  cannabis use ( CU ) frequency and disorder ( CUD ) with  psychotic , depressive and anxiety symptoms in adolescent and adult sample s. Moderating effects of early onset ( ≤ 15 years ) and sex were tested . Design Time‐varying effect models were used to assess the significance of concurrent associations between CU and CUD  and symptoms of psychosis , depression and anxiety at each age . Setting and Participants Adolescent data ( V‐HYS ; n = 662 ) were collected from a r and omly recruited sample of adolescents in Victoria , British Columbia , Canada during a 10‐year period ( 2003–13 ) . Adult cross‐sectional data ( NESARC‐III ; n = 36 309 ) were collected from a representative sample from the United States ( 2012–13 ) .  Measurements Mental health symptoms were assessed using self‐report measures of diagnostic symptoms . CU was based on frequency of past‐year use . Past‐year CUD was based on DSM‐5 criteria . Findings For youth in the V‐HYS , CU was associated with psychotic symptoms following age 22 [ b = 0.13 , 95 % confidence interval ( CI ) = 0.002 , 0.25 ] , with depressive symptoms from ages 16–19 and following age 25 ( b = 0.17 , 95 % CI = 0.003 , 0.34 ) , but not with anxiety symptoms . CUD was associated with psychotic symptoms following age 23 ( b = 0.51 , 95 % CI = 0.01 , 1.01 ) , depressive symptoms at ages 19–20 and following age 25 ( b = 0.71 , 95 % CI = 0.001 , 1.42 ) and anxiety symptoms ages 26–27 only . For adults in the NESARC‐III , CU was associated with mental health symptoms at most ages [ e.g. psychotic symptoms ; age 18 ( b = 0.22 , 95 % CI = 0.10 , 0.33 ) to age 65 ( b = 0.36 , 95 % CI = 0.16 , 0.56 ) ] . CUD was associated with all mental health symptoms across most ages [ e.g. depressive symptoms ; age 18 ( b = 0.96 , 95 % CI = 0.19 , 1.73 ) to age 61 ( b = 1.11 , 95 % CI = 0.01 , 2.21 ) ] . Interactions with sex show stronger associations for females than males in young adulthood [ e.g. V‐HYS  : CUD × sex interaction on psychotic symptoms significant after age 26 ( b = 1.12 , 95 % CI = 0.02 , 2.21 ) ] . Findings were not moderated by early‐onset CU . Conclusions Significant associations between cannabis use ( CU ) frequency and disorder ( CUD ) and psychotic and depressive symptoms in late adolescence and young adulthood extend across adulthood , and include anxiety
The results show that , in particular , frequent cannabis use , especially daily use , and the consumption of high-potency cannabis are associated with a higher risk of developing psychosis .
Moreover , several genotypes moderate the impact of cannabis use on psychosis risk , particularly those involved in the dopamine function , such as AKT1 .
Finally , cannabis use is associated with an earlier psychosis onset and increased risk of transition in individuals at a clinical high risk of psychosis .
These findings indicate that changing cannabis use behavior could be a harm reduction strategy employed to lower the risk of developing psychosis .
Increasing evidence indicates a relationship between  cannabis use and psychosis risk .
Specific factors , such as determinants of cannabis use or the genetic profile of cannabis users , appear to moderate this association .
The present systematic review presents a detailed and up-to- date literature overview on factors that influence the relationship between cannabis use and psychosis risk .