None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .
A Simple Glucose Insulin Regimen for Perioperative Blood Glucose Control: The Vellore Regimen
In this study , we sought a simple , easily implemented method of intraoperative control of blood glucose in diabetic patients in a large multispecialty teaching hospital .  The Vellore regimen , which offers the advantages of a combined glucose insulin and variable rate infusion was evaluated . For every 1 to 50-mg/dL increase in blood glucose concentration more than 100 mg/dL , 1 U of insulin was added to the injection port of a 100-mL measured volume set containing 5 % dextrose in water . Hourly monitoring of blood glucose was performed . The blood glucose control was compared with the different existing techniques followed in the hospital in 204 r and omized patients : 98 in the study and 106 in the control group . The study group had a mean ±sd blood glucose value of 156 ± 36 mg/dL , and the control group ’s value was 189 ± 63 mg/dL ( P = 0.003 ) . The percentage of patients who were poorly controlled ( outside 100 to 200-mg/dL range ) decreased from 51 % to 28 % ( no patient less than 60 mg/dL ) with this regimen as compared with the control group in which it increased from 49 % to 72 % ( 10 patients less than 60 mg/ dL ) ( P = 0.0013 ) . We conclude that the Vellore regimen is simple , effective , and safe for intraoperative blood glucose control
None of the trials examined the effects of the interventions in terms of costs .
AUTHORS ' CONCLUSIONS The included trials did not demonstrate significant differences for most of the outcomes when targeting intensive perioperative glycaemic control compared with conventional glycaemic control in patients with diabetes mellitus .
However , posthoc analysis indicated that intensive glycaemic control was associated with an increased number of patients experiencing hypoglycaemic episodes .
BACKGROUND Patients with diabetes mellitus are at increased risk of postoperative complications .
Data from r and omised clinical trials and meta-analyses point to a potential benefit of intensive glycaemic control , targeting near-normal blood glucose , in patients with hyperglycaemia ( with and without diabetes mellitus ) being su bmi tted to surgical procedures .
However , there is limited evidence concerning this question in patients with diabetes mellitus undergoing surgery .
OBJECTIVES To assess the effects of perioperative glycaemic control for diabetic patients undergoing surgery .