Direct comparison of doses did not show evidence of dose dependence for blood pressure-lowering for any of the other thiazides for which RCT data were available : bendrofluazide , chlorthalidone , cyclopenthiazide , metolazone or indapamide .
This is based on an informal indirect comparison of results observed in other Cochrane review s on ACE inhibitors , ARBs and renin inhibitors compared with placebo , which used similar inclusion /exclusion criteria to the present review .Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides .
These effects were dose-related and were least for hydrochlorothiazide .
Chlorthalidone increased serum glucose but the evidence was unclear for other thiazides .
This systematic review shows that hydrochlorothiazide has a dose-related blood pressure-lowering effect .
Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides
BACKGROUND Hypertension is a modifiable cardiovascular risk factor .
Although it is established that low-dose thiazides reduce mortality as well as cardiovascular morbidity , the dose-related effect of thiazides in decreasing blood pressure has not been subject to a rigorous systematic review .
It is not known whether individual drugs within the thiazide diuretic class differ in their blood pressure-lowering effects and adverse effects .
OBJECTIVES To determine the dose-related decrease in systolic and /or diastolic blood pressure due to thiazide diuretics compared with placebo control in the treatment of patients with primary hypertension .
Secondary outcomes included the dose-related adverse events leading to patient withdrawal and adverse biochemical effects on serum potassium , uric acid , creatinine , glucose and lipids .
Serum Lipoproteins During Treatment with the Antihypertensive Agent Indapamide
Considering the documented , potentially undesirable influence of various thiazide-type or loop diuretics on serum lipoproteins , we prospect ively investigated in 69 men(mean age ± SEM , 32 ± 1 years ) the metabolic effects of the new diuretic-antihypertensive compound indapamide . Compared to placebo , indapamide ( 2.5 mg/day ) given for 6 to 8 weeks lowered ( p < 0.02 to < 0.001 ) blood pressure(supine values from 148/98 ± 3/2 to 137/93 ± 3/2 ) in 29 men with mild to moderate essential hypertension , but not in 40 healthy men . In both groups , significant ( p < 0.05 to < 0.001 ) decreases in body weight ( −0.8 kg ) and plasma potassium ( −0.6 mmol/L ) , and increases in plasma uric acid (= 20 % ) , renin activity (= 200 % ) , and aldosterone documented good compliance . There were no significant changes hi total cholesterol(in all subjects , from 208 ± 6 to 213 ± 6 mg/dl ) , low- or very low-density lipoprotein(VLDL ) cholesterol ( 127 ± 6 to 129 ± 6 and 21 ± 1 to 21 ± 2 respectively ) , high-density lipoprotein cholesterol ( 50 ± 1 to 51 ± 1 mg/dl ) , total triglycerides(Tg ) ( 108 ± 5 to 112 ± 6 mg/dl ) , VLDL-Tg , apoproteins Al and A2 , plasma glucose , epinephrine , norepinephrine , sodium , calcium , magnesium , and creatinine ; apoprotein B ( 84 ± 2 to 88 ± 3 mg/dl ) and plasma insulin after glucose loading dose tended to be increased minimally . The absence of distinct lipoprotein alterations after short-term indapamide treatment may be of clinical and epidemiological interest.(Hypertension 7 [ Suppl II ] : II-164–II-169 , 1985
Direct comparison of doses did not show evidence of dose dependence for blood pressure-lowering for any of the other thiazides for which RCT data were available : bendrofluazide , chlorthalidone , cyclopenthiazide , metolazone or indapamide .
This is based on an informal indirect comparison of results observed in other Cochrane review s on ACE inhibitors , ARBs and renin inhibitors compared with placebo , which used similar inclusion /exclusion criteria to the present review .Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides .
These effects were dose-related and were least for hydrochlorothiazide .
Chlorthalidone increased serum glucose but the evidence was unclear for other thiazides .
This systematic review shows that hydrochlorothiazide has a dose-related blood pressure-lowering effect .
Thiazides reduced potassium , increased uric acid and increased total cholesterol and triglycerides
BACKGROUND Hypertension is a modifiable cardiovascular risk factor .
Although it is established that low-dose thiazides reduce mortality as well as cardiovascular morbidity , the dose-related effect of thiazides in decreasing blood pressure has not been subject to a rigorous systematic review .
It is not known whether individual drugs within the thiazide diuretic class differ in their blood pressure-lowering effects and adverse effects .
OBJECTIVES To determine the dose-related decrease in systolic and /or diastolic blood pressure due to thiazide diuretics compared with placebo control in the treatment of patients with primary hypertension .
Secondary outcomes included the dose-related adverse events leading to patient withdrawal and adverse biochemical effects on serum potassium , uric acid , creatinine , glucose and lipids .