This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .
Regular Consumption of Both Vitamin D– and Calcium- and Vitamin D–Fortified Yogurt Drink Is Equally Accompanied by Lowered Blood Lipoprotein (a) and Elevated Apoprotein A1 in Subjects with Type 2 Diabetes: A Randomized Clinical Trial
Objective : Cardiovascular disease ( CVD ) is the major morbidity and cause of death in diabetic subjects . Observational studies have shown the association of low vitamin D status with poor glycemic control , atherogenic lipid profile , and CVD . However , the possible link between circulating 25-hydroxycholecalciferol and apoproteins ( Apo A1 and B ) and the atherogenic lipoprotein ( a ) [ Lp(a ) ] has not been documented to date . Methods : Ninety subjects with type 2 diabetes ( T2D ) aged 30–60 years from both sexes were r and omly allocated to one of the 3 groups to receive 2 bottles a day of either ( 1 ) plain doogh ( PD ; containing 150 mg calcium and no detectable vitamin D/250 mL ) ; ( 2 ) vitamin D – fortified doogh ( DD ; containing 150 mg calcium and 500 IU vitamin D/250 mL ) ; or ( 3 ) calcium- and vitamin D – fortified doogh ( CDD ; containing 250 mg calcium and 500 IU vitamin D/250 mL ) for 12 weeks . Anthropometric , dietary , and laboratory assessment s , including Apo A1 , Apo B , and Lp(a ) , were done . Results : Improvement of  vitamin  D status in DD and CDD groups , compared to PD , result ed in a significant increase in Apo A1 ( mean changes 0.22 ± 0.38 , 0.20 ± 0.27 and 0.01 ± 0.35 g/L , respectively , p = 0.047 ) and a significant decrease in serum Lp(a ) ( mean changes −0.08 ± 0.30 , −0.08 ± 0.31 , and 0.14 ± 0.25 μmol/L , respectively , p = 0.011 ) . There was no significant difference between DD and CDD groups . Serum Apo B did not change significantly in any of the groups . Conclusions : Significant amelioration of serum Apo A1 and Lp(a ) following improvement of vitamin D status in T2D subjects may have preventive implication s against long-term diabetic complications , notably CVD . This trial was registered at Clinical Trials.gov as NTC01229891
This meta- analysis suggests that vitamin D supplementation improves indices of glycemic control ( FBG , HOMA-IR , and HbA1C ) in patients with diabetes mellitus .
Hence , vitamin D supplements may be of potential therapeutic value in diabetic patients , as an adjuvant therapy along with other treatments
BACKGROUND AND PURPOSE This systematic review and meta- analysis aim ed to assess the effects of vitamin D supplements on indices of glycemic control [ homeostatic model assessment -insulin resistance ( HOMA-IR ) , hemoglobin A1C ( HbA1C ) , fasting blood glucose ( FBG ) , and quantitative insulin-sensitivity check index ( QUICKI ) and lipid profile in diabetic patients .