The two articles that evaluated individuals with dyslipidemia showed improvement in lipid profile .
The mechanisms of action are still being studied .
ABSTRACT In this systematic review , we discuss the scientific evidence about the effect of dietary intake of seeds and sesame derivatives on lipid profile and blood pressure ( BP ) of hypertensive and dyslipidemic individuals .
Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans.
Animal studies suggest that the 2 major omega3 fatty acids found in fish , eicosapentaenoic acid ( EPA ) and docosahexaenoic acid ( DHA ) , may have differential effects on blood pressure ( BP ) and heart rate ( HR ) . The aim of this study was to determine whether there were significant differences in the effects of purified EPA or DHA on ambulatory BP and HR in humans . In a double-blind , placebo-controlled trial of parallel design , 59 overweight , mildly hyperlipidemic men were r and omized to 4 g/d of purified EPA , DHA , or olive oil ( placebo ) capsules and continued their usual diets for 6 weeks . Fifty-six subjects completed the study . Only DHA reduced 24-hour and daytime ( awake ) ambulatory BP ( P<0.05 ) . Relative to the placebo group , 24-hour BP fell 5.8/3.3 ( systolic/diastolic ) mm Hg and daytime BP fell 3.5/2.0 mm Hg with DHA . DHA also significantly reduced 24-hour , daytime , and nighttime ( asleep ) ambulatory HRs ( P=0 . 001 ) . Relative to the placebo group , DHA reduced 24-hour HR by 3 . 5+/-0.8 bpm , daytime HR by 3.7+/-1.2 bpm , and nighttime HR by 2 . 8+/-1.2 . EPA had no significant effect on ambulatory BP or HR . Supplementation with EPA increased plasma phospholipid EPA from 1 . 66+/-0.07 % to 9.83+/-0.06 % ( P<0.0001 ) but did not change DHA levels . Purified DHA capsules increased plasma phospholipid DHA levels from 4.00+/-0.27 % to 10.93+/-0.62 % ( P<0.0001 ) and led to a small , nonsignificant increase in EPA ( 1.52+/-0.12 % to 2.26+/-0.16 % ) . Purified DHA but not EPA reduced ambulatory BP and HR in mildly hyperlipidemic men . The results of this study suggest that DHA is the principal omega3 fatty acid in fish and fish oils that is responsible for their BP- and HR-lowering effects in humans . These results have important implication s for human nutrition and the food industry
The two articles that evaluated individuals with dyslipidemia showed improvement in lipid profile .
The mechanisms of action are still being studied .
ABSTRACT In this systematic review , we discuss the scientific evidence about the effect of dietary intake of seeds and sesame derivatives on lipid profile and blood pressure ( BP ) of hypertensive and dyslipidemic individuals .