Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults , results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters .
This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect
This systematic review aims to evaluate r and omised controlled trials ( RCTs ) investigating the effect of vitamin D supplementation on  endothelial function and inflammation in adults .
The effect of vitamin D replacement on markers of vascular health in stroke patients - a randomised controlled trial.
BACKGROUND AND AIMS Low vitamin D levels are associated with increased incidence of future cardiovascular events and are common in stroke patients . We tested whether vitamin D supplementation could reduce blood pressure and improve markers of vascular health in patients who had previously suffered a stroke . METHODS AND RESULTS R and omised , placebo-controlled , double-blind trial . Community-dwelling patients with a history of stroke and baseline 25-hydroxyvitamin D levels < 75 nmol/L received 100,000 units of oral vitamin D2 or placebo at baseline . Office and 24 h blood pressure , endothelial function measured by flow-mediated dilatation of the brachial artery , cholesterol , oxidised low density lipoprotein , B-type natriuretic peptide and heart rate turbulence were measured at baseline , 8 weeks and 16 weeks . 58 patients were r and omised . Mean age was 67 years , mean baseline blood pressure 128/72 mmHg , mean baseline 25-hydroxyvitamin D level was 38 nmol/L.  Serum 25-hydroxyvitamin D levels were higher in the intervention group at 8 weeks compared to placebo ( 54 vs 42 nmol/L , P = 0.002 ) and remained higher at 16 weeks . Office systolic and diastolic blood pressure showed no significant change between groups at 8 weeks ( systolic 126.1 vs 131.3 mmHg ; adjusted P = 0.97 ) ; ( diastolic 73.1 vs 74.9 mmHg , adjusted P = 0.15 ) . Flow mediated dilatation was significantly higher in the intervention group at 8 weeks ( 6.9 % vs 3.7 % , adjusted P = 0.007 ) but was not significantly different at 16 weeks . CONCLUSIONS High dose oral vitamin D supplementation did not improve blood pressure but produced short-term improvement in endothelial function in stroke patients with well-controlled baseline blood pressure . CLINICAL TRIALS REGISTRATION IS RCT N28737567
Evidence from the studies included in this systematic review did not demonstrate that vitamin D supplementation in adults , results in an improvement in circulating inflammatory and endothelial function biomarkers/parameters .
This systematic review does not therefore support the use of vitamin D supplementation as a therapeutic or preventative measure for CVD in this respect
This systematic review aims to evaluate r and omised controlled trials ( RCTs ) investigating the effect of vitamin D supplementation on  endothelial function and inflammation in adults .