Meta-regression showed that gastric pouch volume , alimentary limb length and biliopancreatic limb length were not associated with changes in ghrelin levels .
Conclusion Fasting total ghrelin levels decreased in the short term ( ≤ 3 months ) and increased in the long term ( > 3 months ) after RYGB
Background Roux-en-Y gastric bypass ( RYGB ) is considered effective for weight loss and for treatment of many obesity-related metabolic diseases .
Ghrelin is an essential orexigenic peptide that plays an indispensable role in controlling body weight and energy homeostasis of post-operative patients .
This systematic review and meta- analysis aim ed to investigate changes in the level of fasting total ghrelin following RYGB .
Effect of Weight Loss by Diet or Gastric Bypass Surgery on Peptide YY3–36 Levels
Objective : To examine the effect of an equivalent weight loss , by gastric bypass surgery ( GBP ) or by diet , on peptide YY3–36 ( PYY3–36 ) , ghrelin , and leptin levels and to determine the effect of diabetes status on PYY3–36 levels . Summary Background Data : The increased PYY3–36 levels after GBP may be involved in the magnitude and the sustainability of weight loss after surgery . Methods : Of the 30 morbidly obese women who participated in the study , 21 had type 2 diabetes mellitus , and were studied before and after equivalent weight loss of 10 kg by either GBP ( n = 11 ) or by diet ( n = 10 ) . Results : PYY3–36 levels were higher in obese diabetic as compared with nondiabetic individuals ( 64.1 ± 34.4 pg/mL vs. 39.9 ± 21.1 pg/mL ; P < 0.05 ) . PYY3–36 levels increased markedly in response to oral glucose after GBP ( peak : 72.3 ± 20.5 pg/mL–132.7 ± 49.7 pg/mL ; P < 0.001 ; AUC0–180 : 51.5 ± 23.3 pg/mL.min−1–91.1 ± 32.2 pg/mL.min−1 P < 0.001 ) , but not after diet ( peak : 85.5 ± 51.9 pg/mL–84.8 ± 41.13 pg/mL ; P = NS ; AUC0–180 : 68.3 ± 38.5 pg/mL.min−1–61.1 ± 42.2 pg/mL.min−1 P = NS ) . Fasting ghrelin levels increased after diet ( 425 ± 91 pg/mL–519 ± 105 pg/mL ; P < 0.05 ) , but did not change after GBP ( 506 ± 121 pg/mL–482 ± 196 pg/mL ; P = NS ) . Conclusions : Diabetes status seems to be a determinant of PYY3–36 levels . GBP , but not diet-induced weight loss , result ed in markedly increased glucose-stimulated PYY3–36 levels . The increase in stimulated PYY3–36 levels after GBP is likely a result of the surgery rather than a secondary outcome of weight loss . Changes in PYY3–36 levels and ghrelin could contribute to the success of GBP in sustaining weight loss
Meta-regression showed that gastric pouch volume , alimentary limb length and biliopancreatic limb length were not associated with changes in ghrelin levels .
Conclusion Fasting total ghrelin levels decreased in the short term ( ≤ 3 months ) and increased in the long term ( > 3 months ) after RYGB
Background Roux-en-Y gastric bypass ( RYGB ) is considered effective for weight loss and for treatment of many obesity-related metabolic diseases .
Ghrelin is an essential orexigenic peptide that plays an indispensable role in controlling body weight and energy homeostasis of post-operative patients .
This systematic review and meta- analysis aim ed to investigate changes in the level of fasting total ghrelin following RYGB .