Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
BACKGROUND Observational and experimental data suggest that antioxidant and /or zinc supplements may delay progression of age-related macular degeneration ( AMD ) and vision loss . OBJECTIVE To evaluate the effect of high-dose vitamins C and E , beta carotene , and zinc supplements on AMD progression and visual acuity . DESIGN The Age-Related Eye Disease Study , an 11-center double-masked clinical trial , enrolled participants in an AMD trial if they had extensive small drusen , intermediate drusen , large drusen , non central geographic atrophy , or pigment abnormalities in 1 or both eyes , or advanced AMD or vision loss due to AMD in 1 eye . At least 1 eye had best-corrected visual acuity of 20/32 or better . Participants were r and omly assigned to receive daily oral tablets containing : ( 1 ) antioxidants ( vitamin C , 500 mg ; vitamin E , 400 IU ; and beta carotene , 15 mg ) ; ( 2 ) zinc , 80 mg , as zinc oxide and copper , 2 mg , as cupric oxide ; ( 3 ) antioxidants plus zinc ; or ( 4 ) placebo . MAIN OUTCOME MEASURES ( 1 ) Photographic assessment of progression to or treatment for advanced AMD and ( 2 ) at least moderate visual acuity loss from baseline ( > or = 15 letters ) . Primary analyses used repeated- measures logistic regression with a significance level of.01 , unadjusted for covariates . Serum level measurements , medical histories , and mortality rates were used for safety monitoring . RESULTS Average follow-up of the 3640 enrolled study participants , aged 55 - 80 years , was 6.3 years , with 2.4 % lost to follow-up . Comparison with placebo demonstrated a statistically significant odds reduction for the development of advanced AMD with antioxidants plus zinc ( odds ratio [ OR ] , 0.72 ; 99 % confidence interval [ CI ] , 0.52 - 0.98 ) . The ORs for zinc alone and antioxidants alone are 0.75 ( 99 % CI , 0.55 - 1.03 ) and 0.80 ( 99 % CI , 0.59 - 1.09 ) , respectively . Participants with extensive small drusen , nonextensive intermediate size drusen , or pigment abnormalities had only a 1.3 % 5-year probability of progression to advanced AMD . Odds reduction estimates increased when these 1063 participants were excluded  ( antioxidants plus zinc : OR , 0.66 ; 99 % CI , 0.47 - 0.91 ; zinc : OR , 0.71 ; 99 % CI , 0.52 - 0.99 ; antioxidants : OR , 0.76 ; 99 % CI , 0.55 - 1.05 ) . Both zinc and antioxidants plus zinc significantly reduced the odds of developing advanced AMD in this higher-risk group . The only statistically significant reduction in rates of at least moderate visual acuity loss occurred in persons assigned to receive antioxidants plus zinc ( OR , 0.73 ; 99 % CI , 0.54 - 0.99 ) . No statistically significant serious adverse effect was associated with any of the formulations . CONCLUSIONS Persons older than 55 years should have dilated eye examinations to determine their risk of developing advanced AMD . Those with extensive intermediate size drusen , at least 1 large druse , non central geographic atrophy in 1 or both eyes , or advanced AMD or vision loss due to AMD in 1 eye , and without contraindications such as smoking , should consider taking a supplement of antioxidants plus zinc such as that used in this study
Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .