There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
A Multicenter Long-Term Safety and Efficacy Trial of Preterm Formula Supplemented with Long-Chain Polyunsaturated Fatty Acids
Background The tissue accretion of long-chain polyunsaturated fatty acids is compromised in infants born prematurely . Human milk contains long-chain polyunsaturated fatty acids , but most preterm infant formulas do not . The long-term effects of preterm formula supplemented with arachidonic acid and docosahexaenoic acid , in proportions typical of those in human milk , were therefore investigated . Methods In this double-blind , r and omized study , 288 preterm infants received experimental formula ( n = 77 ) , unsupplemented ( control ) formula ( n = 78 ) , or human milk ( n = 133 ) until 48 weeks postconceptional age ( PCA ) .  Term formula , without supplemental long-chain polyunsaturated fatty acids , was administered from 48 to 92 weeks PCA to formula-fed infants and to infants weaned from human milk .  Anthropometric and fatty acid data were assessed by using analysis of variance . Results At 92 weeks PCA , no statistically significant anthropometric measurement differences were found except for midarm circumference , which was smaller in human milk – fed infants than in those fed formula . Phospholipid concentrations were similar in the experimental and human milk – fed groups , and docosahexaenoic acid levels were significantly greater than in the control group . The types and incidences of adverse events were similar among the feeding groups . Conclusions The results of this study demonstrate the efficacy and long-term safety of preterm formula supplemented with long-chain polyunsaturated fatty acids
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .