There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain .
Non-steroidal anti-inflammatory drugs ( NSAIDs ) are medications that are frequently used by athletes .
There may also be some abuse of these substances , although it is unclear whether NSAIDs in fact enhance performance .
We performed a systematic review and meta- analysis to evaluate the effect of NSAIDs on sport performance indices .
Nonsteroidal anti-inflammatory drug use and endurance during running in male long-distance runners.
CONTEXT The effect of ibuprofen on pain tolerance during exercise is controversial , and its effects on endurance performance have been poorly investigated . OBJECTIVE To investigate the effect of prophylactic administration of the nonsteroidal anti-inflammatory drug ibuprofen on the time until the self-report of fatigue ( tlim ) in runners with exercise-induced muscle damage . DESIGN R and omized controlled clinical trial . SETTING Laboratory . PATIENTS OR OTHER PARTICIPANTS Twenty healthy male long-distance runners ( age = 18.8 ± 0.4 years , maximal oxygen consumption = 55.5 ± 5.9 mL·kg(-1)·min(-1 ) ) . INTERVENTION(S ) Participants were assigned to 2 groups ( ibuprofen group = 10 , placebo group = 10 ) to perform tlim trials ( speed corresponded to their previously determined secondventilatory thresholds ) 48 hours before and 48 hours after the induction of a lower limb muscle-damage protocol ( isokinetic dynamometry ) . One hour before the second tlim trial , the ibuprofen group received 1.2 g ibuprofen , and the placebo group received lactose orally . MAIN OUTCOME MEASURE(S ) Time until self-reported fatigue , heart rate , respiratory quotient , oxygen consumption , and perceived exertion were recorded during each tlim test . RESULTS Both groups reported increases in muscle pain in the knee extensors and flexors 48 hours after the muscle-damage protocol . We observed a reduction in the endurance performance of both groups ( P < .01 ) but no difference between groups ( P = .55 ) . CONCLUSIONS Ibuprofen did not reduce the effect of muscle damage and pain on performance . Prophylactic use of nonsteroidal anti-inflammatory drugs did not have an ergogenic effect on running performance after exercise-induced muscle damage in male long-distance runners
There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain .
Non-steroidal anti-inflammatory drugs ( NSAIDs ) are medications that are frequently used by athletes .
There may also be some abuse of these substances , although it is unclear whether NSAIDs in fact enhance performance .
We performed a systematic review and meta- analysis to evaluate the effect of NSAIDs on sport performance indices .