In conclusion , bariatric surgery is associated with a reduction in specific adipokines including leptin , chemerin , and PAI-1 , whereas adiponectin is raised , adaptations that could be indicative of improved fat mass and function
Different adipokines secreted from adipose tissue , exert a range of physiological effects .
The aim of present systematic review and meta- analysis was to critically investigate the consequence of  bariatric surgery on circulating adipokines , that is , adiponectin , leptin , visfatin , resistin , plasminogen activator inhibitor , and chemerin .
Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy.
The relationship between insulin action and control of the adipocyte-derived factor adiponectin was studied in age- and weight-matched obese individuals with type 2 diabetes failing sulfonylurea therapy .  After initial metabolic characterization , subjects were r and omized to troglitazone or metformin treatment groups ; all subjects received glyburide ( 10 mg BID ) as well . Treatment was continued for 3 months . The extent of glycemic control after treatment was similar in both groups . However , the increase in maximal insulin-stimulated glucose disposal rate was greater following troglitazone therapy ( + 44 % ) compared with metformin treatment ( + 20 % ) . Troglitazone treatment increased serum adiponectin levels nearly threefold . There was no change in serum adiponectin with metformin treatment . A positive correlation was found between increases in whole-body glucose disposal rates and serum adiponectin levels after troglitazone ; no such relationship was seen with metformin . The adiponectin protein content of subcutaneous abdominal adipocytes was increased following troglitazone treatment and unchanged after metformin .  Adiponectin release from adipocytes was also augmented with troglitazone treatment . Adiponectin was present in adipocytes and plasma in several multimeric forms ; a trimer was the major form secreted from adipocytes . These results indicate that increases in adiponectin content and secretion are associated with improved insulin action but are not directly related to glycemic control . Modulation of adipocyte function , including upregulation of adiponectin synthesis and secretion , may be an important mechanism by which thiazolidinediones influence insulin action
In conclusion , bariatric surgery is associated with a reduction in specific adipokines including leptin , chemerin , and PAI-1 , whereas adiponectin is raised , adaptations that could be indicative of improved fat mass and function
Different adipokines secreted from adipose tissue , exert a range of physiological effects .
The aim of present systematic review and meta- analysis was to critically investigate the consequence of  bariatric surgery on circulating adipokines , that is , adiponectin , leptin , visfatin , resistin , plasminogen activator inhibitor , and chemerin .