Conclusion : The administration of a probiotic mixture containing L. acidophilus DDS-1 , B. lactis UABLA- 12 , and fructo-oligosaccharide was associated with significant clinical improvement in children with AD , with corresponding lymphocyte subset changes in peripheral blood .
Abstract Background : The role of probiotics in the treatment of atopic dermatitis ( AD ) remains controversial .
A recent systematic review of the available evidence called for further clinical trials with new probiotic formulations .
Objective : To assess the clinical efficacy and impact of Lactobacillus acidophilus DDS-1 , Bifidobacterium lactis UABLA-12 with fructo-oligosaccharide on peripheral blood lymphocyte subsets in preschool children with moderate-to-severe AD .
Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life.
BACKGROUND Allergic diseases have been linked to abnormal patterns of immune development , and this has stimulated efforts to define the precise patterns of cytokine dysregulation that are associated with specific atopic phenotypes . OBJECTIVE Cytokine-response profiles were prospect ively analyzed over the first year of life and compared with the clinical and immunologic expressions of atopy . METHODS Umbilical cord and 1-year P BMC s were obtained from 285 subjects from allergic families .  PHA-stimulated cytokine-response profiles ( IL-5 , IL-10 , IL-13 , and IFN-gamma ) were compared with blood eosinophil counts and total and specific IgE levels ( dust mites , cat , egg , Alternaria species , peanut , milk , and dog ) at age 1 year and at the development of atopic dermatitis and food allergy . RESULTS For the cohort as a whole , cytokine responses did not evolve according to a strict TH1 or TH2 polarization pattern . PHA-stimulated cord blood cells secreted low levels of IL-5 ( 2.1 pg/mL ) , moderate levels of IFN-gamma ( 57.4 pg/mL ) , and greater amounts of IL-13 ( 281.8 pg/mL ) . From birth to 1 year , IL-5 responses dramatically increased , whereas IL-13 and IFN-gamma responses significantly decreased . Reduced cord blood secretion of IL-10 and IFN-gamma was associated with subsequent sensitization to egg . In addition , there was evidence of TH2 polarization ( increased IL-5 and IL-13 levels ) associated with blood eosinophilia and increased total IgE levels by age 1 year . CONCLUSION These findings demonstrate that cytokine responses change markedly during the first year of life and provide further evidence of a close relationship between TH2 skewing of immune responses and the incidence of atopic manifestations in children
Conclusion : The administration of a probiotic mixture containing L. acidophilus DDS-1 , B. lactis UABLA- 12 , and fructo-oligosaccharide was associated with significant clinical improvement in children with AD , with corresponding lymphocyte subset changes in peripheral blood .
Abstract Background : The role of probiotics in the treatment of atopic dermatitis ( AD ) remains controversial .
A recent systematic review of the available evidence called for further clinical trials with new probiotic formulations .
Objective : To assess the clinical efficacy and impact of Lactobacillus acidophilus DDS-1 , Bifidobacterium lactis UABLA-12 with fructo-oligosaccharide on peripheral blood lymphocyte subsets in preschool children with moderate-to-severe AD .