They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .
Comparison between daily supplementation doses of 200 versus 400 IU of vitamin D in infants
The daily supplementation of vitamin D is m and atory for infants . However , there are still conflicting opinions about the exact daily dose . Thus , we aim ed to evaluate a daily supplementation dose of 200 IU is sufficient and compared the supplementation doses of 200 and 400 IU per day . One hundred and sixty-nine infants were r and omly assigned to two groups ( group1 , 200 IU/day ; group 2 , 400 IU/day ) and there were 75 infants in group 1 and 64 were in group 2 with a total number of 139 . The median levels of 25-hydroxyvitamin D3 were significantly increased in group 2 at the age of 4 months ( group 1 , 39.60 mcg/L ; group 2 , 56.55 mcg/L ; p < 0.0001 ) . We clearly demonstrated that at the age of 4 months , none of the infants on the group 2 had a serum level of 25-hydroxyvitamin D3 less than 30 mcg/L. However , 21.3 % of the infants in group 1 had a level below 30 mcg/L. Thus , in order to avoid vitamin D deficiency and rickets , we recommend supplementation dose of vitamin D at 400 IU/day as a safe and effective dose
They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .