This review found no clear or consistent evidence that genetic risk communication alone either raises motivation or translates into actual change in dietary intake or physical activity to reduce the risk of cardiometabolic disorders in adults .
Genetic risk prediction of chronic conditions including obesity , diabetes and CVD currently has limited predictive power but its potential to engage healthy behaviour change has been of immense research interest .
We aim ed to underst and whether the latter is indeed true by conducting a systematic review and meta- analysis investigating whether genetic risk communication affects motivation and actual behaviour change towards preventative lifestyle modification .
The clinical application of genetic testing in type 2 diabetes: a patient and physician survey
Aims /hypothesisAdvances in type 2 diabetes genetics have raised hopes that genetic testing will improve disease prediction , prevention and treatment . Little is known about current physician and patient views regarding type 2 diabetes genetic testing . We hypothesised that physician and patient views would differ regarding the impact of genetic testing on motivation and adherence . Methods We surveyed a nationally representative sample of US primary care physicians and endocrinologists ( n = 304 ) , a r and om sample of non-diabetic primary care patients ( n = 152 ) and patients enrolled in a diabetes pharmacogenetics study ( n = 89 ) . Results Physicians and patients favoured genetic testing for diabetes risk prediction ( 79 % of physicians vs 80 % of non-diabetic patients would be somewhat/very likely to order/request testing , p = 0.7 ) . More patients than physicians ( 71 % vs 23 % , p < 0.01 ) indicated that a ‘ high risk ’ result would be very likely to improve motivation to adopt preventive lifestyle changes . Patients favoured  genetic testing to guide therapy ( 78 % of patients vs 48 % of physicians very likely to request/recommend testing , p < 0.01 ) and reported that genetic testing would make them ‘ much more motivated ’ to adhere to medications ( 72 % vs 18 % of physicians , p < 0.01 ) . Many physicians ( 39 % ) would be somewhat/very likely to order genetic testing before published evidence of clinical efficacy . Conclusions /interpretationDespite the paucity of current data , physicians and patients reported high expectations that genetic testing would improve patient motivation to adopt key behaviours for the prevention or control of type 2 diabetes . This suggests the testable hypothesis that ‘ genetic ’ risk information might have greater value to motivate behaviour change compared with st and ard risk information
This review found no clear or consistent evidence that genetic risk communication alone either raises motivation or translates into actual change in dietary intake or physical activity to reduce the risk of cardiometabolic disorders in adults .
Genetic risk prediction of chronic conditions including obesity , diabetes and CVD currently has limited predictive power but its potential to engage healthy behaviour change has been of immense research interest .
We aim ed to underst and whether the latter is indeed true by conducting a systematic review and meta- analysis investigating whether genetic risk communication affects motivation and actual behaviour change towards preventative lifestyle modification .