No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .
Randomised masked clinical trial of the MGDRx eyebag for the treatment of meibomian gland dysfunction-related evaporative dry eye
Background / aims To investigate the efficacy and safety of the MGDRx EyeBag ( The Eyebag Company , Halifax , UK ) eyelid warming device . Methods Twenty-five patients with confirmed meibomian gl and dysfunction (MGD)-related evaporative dry eye were enrolled into a r and omised , single masked , contralateral clinical trial . Test eyes received a heated device ; control eyes a non-heated device for 5 min twice a day for 2 weeks . Efficacy ( ocular symptomology , non-invasive break-up time , lipid layer thickness , osmolarity , meibomian gl and dropout and function ) and safety ( visual acuity , corneal topography , conjunctival hyperaemia and staining ) measurements were taken at baseline and follow-up . Subsequent patient device usage and ocular comfort was ascertained at 6 months . Results Differences between test and control eyes at baseline were not statistically significant for all measurements ( p>0.05 ) . After 2 weeks , statistically significant improvements occurred in all efficacy measurements in test eyes ( p<0.05 ) . Visual acuity and corneal topography were unaffected ( p>0.05 ) . All patients maintained higher ocular comfort after 6 months ( p<0.05 ) , although the benefit was greater in those who continued usage 1–8 times a month ( p<0.001 ) . Conclusions The MGDRx EyeBag is a safe and effective device for the treatment of MGD-related evaporative dry eye . Subjective benefit lasts at least 6 months , aided by occasional retreatment . Trial registration number NCT01870180
No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .