The literature on risk factors for cardiometabolic diseases showed that lutein might be beneficial for atherosclerosis and inflammatory markers , but there were inconsistent associations with blood pressure , adiposity , insulin resistance , and blood lipids .
CONCLUSIONS Our findings suggest that higher dietary intake and higher blood concentrations of lutein are generally associated with better cardiometabolic health .
BACKGROUND The antioxidant lutein is suggested as being beneficial to cardiometabolic health because of its protective effect against oxidative stress , but evidence has not systematic ally been evaluated .
OBJECTIVE We aim ed to evaluate systematic ally the effects of lutein ( intake or concentrations ) on cardiometabolic outcomes in different life stages .
Some dietary and adipose tissue carotenoids are associated with the risk of nonfatal acute myocardial infarction in Costa Rica.
Antioxidants , particularly carotenoids and tocopherols , may protect against cardiovascular disease . The objective of this study was to determine whether dietary and adipose tissue carotenoids and tocopherols are associated with the risk of myocardial infa rct ion ( MI ) . Cases ( n = 1456 ) of a first acute MI were identified and matched by age , sex , and residence to r and omly selected population controls ( n = 1456 ) living in Costa Rica .  Carotenoids and tocopherols were measured in adipose tissue using HPLC .  Dietary intake was assessed using a vali date d FFQ . Anthropometrical and lifestyle data were collected using an interviewer-administered question naire . Subjects were distributed into quintiles of intake or adipose tissue concentration of carotenoids or tocopherols . The lowest quintile was used as the referent in conditional logistic regression analyses . Adipose tissue beta-carotene showed a significant inverse relation with MI risk ; the odds ratio ( OR ) comparing the highest to the lowest quintile was 0.70 ( 95 % CI : 0.51 - 0.96 , P for trend = 0.02 ) . Intake of fruits and vegetables that are rich in beta-carotene was also inversely associated with the risk of MI ( OR = 0.74 ; CI : 0.54 - 1.01 , P for trend = 0.09 ) . In contrast , lutein + zeaxanthin in adipose tissue ( OR = 1.46 ; CI : 1.05 - 2.05 , P for trend = 0.02 ) and diet ( OR = 1.18 ; CI : 0.88 - 1.57 , P for trend = 0.02 ) was positively associated with MI risk . MI risk was not associated with any of the other carotenoids or tocopherols in the diet or adipose tissue . Thus , the inverse association between beta-carotene and MI risk suggests that beta-carotene protects against MI or it is a marker of some protective factor in foods containing beta-carotene . The mechanism underlying the positive association between lutein + zeaxanthin and the risk of MI warrants investigation
The literature on risk factors for cardiometabolic diseases showed that lutein might be beneficial for atherosclerosis and inflammatory markers , but there were inconsistent associations with blood pressure , adiposity , insulin resistance , and blood lipids .
CONCLUSIONS Our findings suggest that higher dietary intake and higher blood concentrations of lutein are generally associated with better cardiometabolic health .
BACKGROUND The antioxidant lutein is suggested as being beneficial to cardiometabolic health because of its protective effect against oxidative stress , but evidence has not systematic ally been evaluated .
OBJECTIVE We aim ed to evaluate systematic ally the effects of lutein ( intake or concentrations ) on cardiometabolic outcomes in different life stages .