They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .
Effect of different dosages of oral vitamin D supplementation on vitamin D status in healthy, breastfed infants: a randomized trial.
IMPORTANCE Vitamin D supplementation in infancy is required to support healthy bone mineral accretion . A supplement of 400 IU of vitamin D per day is thought to support plasma 25-hydroxyvitamin D ( 25[OH]D ) concentrations between 40 and 50 nmol/L ; some advocate 75 to 150 nmol/L for bone health . OBJECTIVE To investigate the efficacy of different dosages of vitamin D in supporting 25(OH)D concentrations in infants . DESIGN , SETTING , AND PARTICIPANTS Double-blind r and omized clinical trial conducted among 132 one-month-old healthy , term , breastfed infants from Montréal , Québec , Canada , between March 2007 and August 2010 . Infants were followed up for 11 months ending August 2011 ( 74 % completed study ) . INTERVENTION Participants were r and omly assigned to receive oral cholecalciferol ( vitamin D3 ) supplements of 400 IU/d ( n=39 ) , 800 IU/d ( n=39 ) , 1200 IU/d ( n=38 ) , or 1600 IU/d ( n=16 ) . MAIN OUTCOMES AND MEASURES The primary outcome was a plasma 25(OH)D concentration of 75 nmol/L or greater in 97.5 % of infants at 3 months . Secondary outcomes included 25(OH)D concentrations of 75 nmol/L or greater in 97.5 % of infants at 6 , 9 , and 12 months ; 25(OH)D concentrations of 50 nmol/L or greater across all times ; growth ; and whole body and regional bone mineral content . Data were analyzed by intention to treat using available data , logistic regression , and mixed-model analysis of variance . RESULTS By 3 months , 55 % ( 95 % CI , 38%-72 % ) of infants in the 400-IU/d group achieved a 25(OH)D concentration of 75 nmol/L or greater vs 81%(95 % CI , 65%-91 % ) in the 800-IU/d group , 92 % ( 95 % CI , 77%-98 % ) in the 1200-IU/d group , and 100 % in the 1600-IU/d group . This concentration was not sustained in 97.5 % of infants at 12 months in any of the groups . The 1600-IU/d dosage was discontinued prematurely because of elevated plasma 25(OH)D concentrations . All dosages established 25(OH)D concentrations of 50 nmol/L or greater in 97 % ( 95 % CI , 94%-100 % ) of infants at 3 months and sustained this in 98 % ( 95 % CI , 94%-100 % ) to 12 months . Growth and bone mineral content did not differ by dosage . CONCLUSIONS AND RELEVANCE Among healthy , term , breastfed infants , only a vitamin D supplement dosage of 1600 IU/d ( but not dosages of 400 , 800 , or 1200 IU/d ) increased plasma 25(OH)D concentration to 75 nmol/L or greater in 97.5 % of infants at 3 months . However , this dosage increased 25(OH)D concentrations to levels that have been associated with hypercalcemia . TRIAL REGISTRATION clinical trials.gov Identifier : NCT00381914
They do not provide any additional evidence that larger , more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose , affect any significant outcome .
Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects .
Summary There are still many unanswered questions left , in particular whether or not more ‘ generous ’ amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis , allergies , or cancer
Purpose of review New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature .