There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
A Critical Appraisal of the Role of Dietary Long-Chain Polyunsaturated Fatty Acids on Neural Indices of Term Infants: A Randomized, Controlled Trial
Objective . To determine whether dietary long-chain polyunsaturated fatty acids ( LCPUFA ) , such as docosahexaenoic acid ( DHA ) and arachidonic acid , affect visual evoked potential ( VEP ) acuity of formula-fed infants , relative to breastfed infants . A secondary objective was to assess the effect of LCPUFA on Bayley 's mental developmental index ( MDI ) and psychomotor developmental index ( PDI ) . Methods . Formula-fed infants were r and omly allocated , in a double-blind manner , to either a placebo ( no LCPUFA;n = 21 ) , DHA supplemented ( n = 23 ) , or DHA+arachidonic acid supplemented formula ( n = 24 ) . Infants were fed their assigned formula from the first week of life until 1 year of age . A parallel reference group of breastfed infants was recruited and followed ( n = 46 ) . Infant VEP acuity was assessed at 16 and 34 weeks , and Bayley 's MDI and PDI were assessed at 1 and 2 years of age . Results . There were no differences among the r and omized formula groups for VEP acuity at either 16 or 34 weeks of age . Breastfed infants had better VEP acuity at 34 weeks of age , but not at 16 weeks , compared with all formula-fed infants . Bayley 's MDI and PDI were similar in the 3 formula-fed groups at 1 and 2 years . Breastfed infants had higher MDI scores than formula-fed infants at 2 years of age even after adjusting for environmental variables . Conclusions . LCPUFA supplementation did not influence VEP acuity development in these well-nourished , formula-fed infants
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .