We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .
Fluctuations in blood lipid levels during furosemide therapy: a randomized, double-blind, placebo-controlled crossover study.
BACKGROUND Acute decreases in intravascular volume are associated with increases in lipid levels . Furosemide causes acute changes in intravascular volume during prolonged therapy but is thought to have little effect on lipid levels . METHODS To determine if there are daily acute rises in lipid and lipoprotein levels associated with changes in intravascular volume during long-term furosemide ingestion therapy , we performed a r and omized , double-blind , placebo-controlled crossover study in 10 patients . RESULTS In the 8 hours after furosemide ingestion there were increases in levels of plasma cholesterol ( 10.1 % ; P = .001 ) , high-density lipoprotein cholesterol ( 9.0 % ; P = .006 ) , and apolipoprotein B ( 9.8 % ; P = .003 ) . The increases in levels of triglycerides ( 11.5 % ; P = .17 ) and apolipoprotein A-1 ( 13.3 % ; P = .051 ) were of similar magnitude but more variable and did not achieve statistical significance . There was no substantial change in the total cholesterol-high-density lipoprotein cholesterol ratio ( 0.6 % ; 95 % CI,-0.74 % to 8.6 % ; P = .88 ) . CONCLUSION This study indicates that there are acute increases in lipid levels after furosemide ingestion during prolonged therapy , which could affect the interpretation of lipid levels and cardiovascular risk in patients
We found no clinical ly meaningful blood pressure-lowering differences between different drugs within the loop diuretic class .
BACKGROUND Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity .
Loop diuretics are indicated and used to treat hypertension , but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from r and omized controlled trial ( RCT ) evidence has not been conducted .
OBJECTIVES To determine the dose-related decrease in systolic or diastolic blood pressure , or both , as well as adverse events leading to participant withdrawal and adverse biochemical effects ( serum potassium , uric acid , creatinine , glucose and lipids profile ) due to loop diuretics versus placebo control in the treatment of people with primary hypertension .