The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Evaluation of the dose-effect relationship of a new ace inhibitor (perindopril) by an automatic blood pressure recorder.
Repeated blood pressure recordings by non-invasive devices are of better predictive value than single measurements in the evaluation of antihypertensive treatment . Such a method has been used to establish the dose-effect relationship of perindopril . After a two-week placebo run-in period , 40 patients with essential hypertension ( age 56.6 + /- 1.5 years , 31 males , nine females ) were treated with placebo or 2 , 4 or 8 mg of perindopril once daily for one month following a r and omized double-blind design . They were included if at least 75 % of diastolic blood pressure recordings , made over an 8 h diurnal period using an automatic blood pressure recorder , were greater than 95 mmHg on placebo . Values ( mean + /- SEM ) before and after treatment were assessed using analysis of variance . These data showed a significantly greater reduction of blood pressure with 4 mg and 8 mg daily doses compared to placebo and the 2 mg daily dose . Such results were not obtained with blood pressure levels recorded by a mercury sphygmomanometer , confirming the value of an automatic blood pressure recorder as a tool in therapeutic trials
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .