This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .
Dexamethasone in Combination with Dolasetron for Prophylaxis in the Ambulatory Setting: Effect on Outcome after Laparoscopic Cholecystectomy
Background Postoperative nausea and vomiting after laparoscopic cholecystectomy remains a common problem despite routine antiemetic prophylaxis . Therefore , the authors investigated the effect of administering 4 mg intravenous dexamethasone as an adjunct to a 5-HT3 antagonist ( 12.5 mg intravenous dolasetron ) with respect to patient outcome . Methods Out patients ( N = 140 ) were enrolled in this prospect i ve , r and omized , placebo-controlled , double-blind , institutional review board – approved protocol involving two antiemetic treatment groups . After induction of anesthesia , the control group received 1 ml intravenous saline , whereas the dexamethasone group received 4 mg intravenous dexamethasone . Both groups received 12.5 mg intravenous dolasetron at the time of gallbladder removal . A blinded observer recorded the recovery times , emetic episodes , rescue antiemetics , maximum nausea score , and time to achieve discharge criteria . Postdischarge side effects , as well as patient satisfaction and quality of recovery scores were assessed at 24 h after surgery . Results Although there was no difference in the incidence of postoperative nausea and vomiting in the early recovery period , the dexamethasone group had a shorter stay in the day-surgery unit ( 136 ± 57 vs. 179 ± 62 min ) and more rapidly achieved discharge criteria ( 161 ± 32 vs. 209 ± 39 min ) . In addition , fewer patients in the dexamethasone group experienced nausea at home within 24 h after discharge ( 13 vs. 28 % , P < 0.05 ) . Finally , the dexamethasone group reported higher quality of recovery and patient satisfaction scores ( P < 0.05 ) . Conclusions The authors conclude that the adjunctive use of 4 mg intravenous dexamethasone shortened the time to achieve discharge criteria and improved the quality of recovery and patient satisfaction scores after laparoscopic cholecystectomy procedures in out patients receiving prophylaxis with 12.5 mg intravenous dolasetron
This approach has been design ed to provide adequate analgesia while minimizing exposure to adverse events
Background : Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain .
However , a systematic review of postoperative pain management in this procedure has not been conducted .