No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .
Effects of L-carnitine supplementation on biomarkers of oxidative stress, antioxidant capacity and lipid profile, in patients with pemphigus vulgaris: a randomized, double-blind, placebo-controlled trial
Background / Objectives : Pemphigus vulgaris ( PV ) , as an autoimmune disease including mucosa and the skin , is associated with several complications and comorbidities . The present study planned to determine the effect of L-carnitine ( LC ) supplementation on biomarkers of oxidative stress ( OS ) , antioxidant capacity and lipid profile in PV patients .Subjects/ Methods Fifty two control and patients with PV , participated in the current r and omized , double-blind , placebo-controlled clinical trial . The patients were allocated r and omly to receive 2 g per day LC tartrate subdivided into two equal doses of 1 g before breakfast and dinner ( n=26 ) or placebo ( n=26 ) for 8 weeks . Anthropometric , lipid profile and OS values were determined at baseline and end of intervention period . Results : LC intake significantly reduced serum levels of triglycerides , total- , LDL- cholesterol and oxidative stress index ( OSI ; P<0.05 ) . In addition , supplementation with LC result ed to a meaningful increase in levels of total antioxidant capacity ( TAC ) ( P=0.05 ) and serum carnitine ( P<0.001 ) . LC intake revealed non-significant change in serum total oxidant capacity ( P=0.15 ) and HDL- cholesterol ( P=0.06 ) in comparison to the placebo . Conclusions : LC consumption may have favorable results on TAC , OSI and lipid profiles in patients with PV . The results were in line with the idea that LC supplementation can be associated with positive effects on metabolic status and OS of patients with PV
No significant effect was seen for waist circumference ( WC ) and body fat percent .
A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction ( P < 0.001 ) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults .
This association was not seen for BMI , WC and body fat percent .
CONCLUSIONS l-carnitine supplementation provides a modest reducing effect on body weight , BMI and fat mass , especially among adults with overweight/obesity
BACKGROUND AND AIM Clinical evidence which investigated the effects of l-carnitine , a vitamin-like substance , on weight loss had led to inconsistent results .
This study therefore aim ed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of r and omized controlled trials ( RCTs ) and to conduct a dose-response analysis , for the first time .