CLINICAL IMPLICATION S Only SCORAD , EASI , and POEM currently perform adequately .
BACKGROUND Valid and reliable outcome measurements are a prerequisite for evidence -based practice .
The comparative validity and reliability of outcome measurements for assessing atopic eczema ( AE ) severity is unclear .
OBJECTIVE We sought to assess the validity , reliability , sensitivity to change , and ease of use of outcome measurements for AE .
We also sought to give recommendations on which outcomes to use in clinical research and for clinical monitoring .
A randomised, double-blind, vehicle-controlled study to evaluate the efficacy and safety of MAS063D (Atopiclair) in the treatment of mild to moderate atopic dermatitis.
MAS063D ( Atopiclair is a hydrolipidic cream that has been developed for the management of atopic dermatitis ( AD ) . The putative active ingredients of MAS063D are hyaluronic acid , telmesteine , Vitis vinifera , glycyrrhetinic acid . A five-week study in 30 adult patients with mild to moderate AD showed that MAS063D offered significant benefits over a vehicle-only control . MAS063D improved the total body area affected ( 17.2 % -- > 13.2 % , p < 0.001 ) , itch score ( 2.7 -- > 1.3 on a 10-point scale , p = 0.001 ) and EASI score ( 28.3 -- > 24.3 , p = 0.024 ) after 22 days treatment compared to baseline . The patients ' opinion of MAS063D ( patient 's view of itch control , and view of study substance ) was rated by participating patients as significantly better than control ( p = 0.008 , p = 0.042 respectively ) . Based on these preliminary results in a small scale study , it is suggested that MAS063D is a possible new treatment option for improving signs and symptoms in adults with mild to moderate AD
CLINICAL IMPLICATION S Only SCORAD , EASI , and POEM currently perform adequately .
BACKGROUND Valid and reliable outcome measurements are a prerequisite for evidence -based practice .
The comparative validity and reliability of outcome measurements for assessing atopic eczema ( AE ) severity is unclear .
OBJECTIVE We sought to assess the validity , reliability , sensitivity to change , and ease of use of outcome measurements for AE .
We also sought to give recommendations on which outcomes to use in clinical research and for clinical monitoring .