While no clinical trial to date has specifically targeted fatigue , r and omized controlled trials , systematic review s , and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue .
Fatigue is a disabling , multifaceted symptom that is highly prevalent and stubbornly persistent .
Although fatigue is a frequent complaint among patients with fibromyalgia , it has not received the same attention as pain .
Reasons for this include lack of st and ardized nomenclature to communicate about fatigue , lack of evidence -based guidelines for fatigue assessment , and a deficiency in effective treatment strategies .
Fatigue does not occur in isolation ; rather , it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain , unrefreshing sleep , anxiety , depression , cognitive difficulties , and so on .
Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms .
Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia?
Fibromyalgia ( FM ) is a complex disorder that affects up to 5 % of the general population worldwide . Its pathophysiological mechanisms are difficult to identify and current drug therapies demonstrate limited effectiveness . Both mitochondrial dysfunction and coenzyme Q10 ( CoQ10 ) deficiency have been implicated in FM pathophysiology . We have investigated the effect of CoQ10 supplementation . We carried out a r and omized , double-blind , placebo-controlled trial to evaluate clinical and gene expression effects of forty days of CoQ10 supplementation ( 300 mg/day ) on 20 FM patients . This study was registered with controlled-trials.com ( IS RCT N 21164124 ) . An important clinical improvement was evident after CoQ10 versus placebo treatment showing a reduction of FIQ ( p<0.001 ) , and a most prominent reduction in pain ( p<0.001 ) , fatigue , and morning tiredness ( p<0.01 ) subscales from FIQ . Furthermore , we observed an important reduction in the pain visual scale ( p<0.01 ) and a reduction in tender points ( p<0.01 ) , including recovery of inflammation , antioxidant enzymes , mitochondrial biogenesis , and AMPK gene expression levels , associated with phosphorylation of the AMPK activity . These results lead to the hypothesis that CoQ10 have a potential therapeutic effect in FM , and indicate new potential molecular targets for the therapy of this disease . AMPK could be implicated in the pathophysiology of FM
While no clinical trial to date has specifically targeted fatigue , r and omized controlled trials , systematic review s , and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue .
Fatigue is a disabling , multifaceted symptom that is highly prevalent and stubbornly persistent .
Although fatigue is a frequent complaint among patients with fibromyalgia , it has not received the same attention as pain .
Reasons for this include lack of st and ardized nomenclature to communicate about fatigue , lack of evidence -based guidelines for fatigue assessment , and a deficiency in effective treatment strategies .
Fatigue does not occur in isolation ; rather , it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain , unrefreshing sleep , anxiety , depression , cognitive difficulties , and so on .
Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms .