Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .
Effect of α-Lipoic Acid on Platelet Reactivity in Type 1 Diabetic Patients
OBJECTIVE Type 1 diabetes is associated with increased platelet reactivity . We investigated whether α-lipoic acid ( ALA ) has any effect on platelet reactivity in these patients . RESEARCH DESIGN AND METHODS We r and omly assigned 51 type 1 diabetic patients to ALA  ( 600 mg once daily ) or placebo for 5 weeks . Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 platelet expression . C-reactive protein ( CRP ) and 8-iso-prostagl and in F2α serum levels also were measured . RESULTS Baseline variables were similar in the two groups . After treatment , closure time was longer ( P = 0.006 ) and CD62P platelet expression was lower , both before ( P = 0.002 ) and after ( P = 0.009 ) ADP stimulation in the ALA group compared with the placebo group . CRP and 8-iso-prostagl and in F2α levels showed no differences between the two groups . CONCLUSIONS Our data show that ALA reduces measures of platelet reactivity ex vivo in type 1 diabetic patients , independently of antioxidant or anti-inflammatory effects
Our results indicated possible decreasing effect of ALA on inflammatory mediators especially in high dose .
& NA ; Alpha‐Lipoic Acid ( ALA ) is a natural antioxidant compound which is naturally found in plant sources .
New evidence revealed that ALA can reduce inflammation .
Our objective in this meta‐ analysis was to conduct a systematic review and meta‐ analysis on r and omized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor‐alpha ( TNF‐&agr ; ) , c‐reactive protein ( CRP ) , and interleukin‐6 ( IL‐6 ) .