Subgroup analysis for assay type was statistically significant for spontaneous POI only .
Sensitivity analyses of high- quality studies did not change the results , and result ed in a substantial decrease in heterogeneity in spontaneous POI studies .
The current meta- analysis demonstrates that total testosterone concentrations are decreased in women with spontaneous POI or iatrogenic menopause .
BACKGROUND Increasing age and post-menopausal status are associated with decreasing and rogen concentrations in females .
Women with premature loss of ovarian function , such as primary ovarian insufficiency ( POI ) or iatrogenic menopause may be at increased risk for diminished testosterone levels at a relatively young age .
Differentiation between a hypo and rogenic or normo and rogenic state in women with premature loss of ovarian function is problematic due to trueness and precision problems using various testosterone assays .
The current meta- analysis was conducted to evaluate current literature reporting serum total testosterone concentrations under these conditions , including stratification for various testosterone assays .
Endogenous androgen levels and well-being: differences between premenopausal and postmenopausal women
Objective : We investigated whether there is a relationship between and rogens levels and well-being in pre- and postmenopausal women . Design : We r and omly recruited 1423 women aged 18 to 75 years from the community via the electoral roll . Each provided a morning blood sample and completed the Psychological General Well Being Index question naire on the same day . Women were excluded if they took medication for any psychiatric illness , had abnormal thyroid function , or had documented polycystic ovarian syndrome . Analysis was by linear regression for well-being , including demographic and lifestyle variables as well as serum levels of and rogens . Results : We included 1224 women in the analysis . Being partnered was positively associated with well-being in premenopausal women . In postmenopausal women , well-being was positively related to age and exercising , whereas smoking , obesity , and postmenopausal hormone therapy use were each negatively associated with well-being . None of the measured and rogens ( total and free testosterone , dehydroepi and rosterone sulfate , and and rostenedione ) made an independent contribution to well-being in postmenopausal women ( n = 603 ) . However , for premenopausal women ( n = 621 ) , levels of dehydroepi and rosterone sulfate were independently and positively associated with the domain score for vitality . Conclusions : Our findings do not support an important independent role for and rogens as determinants of well-being in postmenopausal women . That dehydroepi and rosterone sulfate alone is associated with greater vitality in premenopausal women is of interest but requires further evaluation as an a priori hypothesis in another study
Subgroup analysis for assay type was statistically significant for spontaneous POI only .
Sensitivity analyses of high- quality studies did not change the results , and result ed in a substantial decrease in heterogeneity in spontaneous POI studies .
The current meta- analysis demonstrates that total testosterone concentrations are decreased in women with spontaneous POI or iatrogenic menopause .
BACKGROUND Increasing age and post-menopausal status are associated with decreasing and rogen concentrations in females .
Women with premature loss of ovarian function , such as primary ovarian insufficiency ( POI ) or iatrogenic menopause may be at increased risk for diminished testosterone levels at a relatively young age .
Differentiation between a hypo and rogenic or normo and rogenic state in women with premature loss of ovarian function is problematic due to trueness and precision problems using various testosterone assays .
The current meta- analysis was conducted to evaluate current literature reporting serum total testosterone concentrations under these conditions , including stratification for various testosterone assays .