Conclusion Various methods have been used at all stages of CSPBM development .
The choice between developing a classification system de novo or from an existing instrument may depend on the availability of a suitable existing measure , while the choice between a decomposed or composite approach appears to be determined primarily by the purpose for which the instrument is design ed .
Background Health state utility values ( HSUVs ) are required to calculate quality -adjusted life-years ( QALYs ) .
They are frequently derived from generic preference-based measures of health .
However , such generic measures may not capture health attributes of relevance to specific conditions .
In such cases , a condition-specific preference-based measure ( CSPBM ) may be more appropriate .
Objective This systematic review aim ed to identify all published accounts of developing CSPBMs to describe and appraise the methods used .
Eliciting health state utilities for Dupuytren’s contracture using a discrete choice experiment
Background and purpose An internet-based discrete choice experiment ( DCE ) was conducted to elicit preferences for a wide range of Dupuytren ’s contracture (DC)-related health states . An algorithm was subsequently developed to convert these preferences into health state utilities that can be used to assess DC ’s impact on quality of life and the value of its treatments . Methods Health state preferences for varying levels of DC h and severity were elicited via an internet survey from a sample of the UK adult population . Severity levels were defined using a combination of contractures ( 0 , 45 , or 90 degrees ) in 8 proximal interphalangeal and metacarpophalangeal joints of the index , middle , ring , and little fingers . Right-h and ed , left-h and ed , and ambidextrous respondents indicated which h and was preferable in each of the 10 r and omly-selected h and -pairings comparing different DC severity levels . For consistency across comparisons , anatomically precise digital h and drawings were used . To anchor preferences onto the traditional 0–1 utility scale used in health economic evaluations , unaffected h and s were assigned a utility of 1.0 whereas the utility for a maximally affected h and ( i.e. , all 8 joints set at 90 degrees of contracture ) was derived by asking respondents to indicate what combination of attributes and levels of the EQ-5D-5L profile most accurately reflects the impact of living with such h and . Conditional logistic models were used to estimate indirect utilities , then rescaled to the anchor points on the EQ-5D-5L . Results Estimated utilities based on the responses of 1,745 qualified respondents were 0.49 , 0.57 , and 0.63 for completely affected dominant h and s , non-dominant h and s , or ambidextrous h and s , respectively . Utility for a dominant h and with 90-degree contracture in t h e metacarpophalangeal joints of the ring and little fingers was estimated to be 0.89 . Separately , reducing the contracture of metacarpophalangeal joint for a little finger from 50 to 12 degrees would improve utility by 0.02 . Interpretation DC is associated with substantial utility decre- ments . The algorithms presented herein provide a robust and flexible framework to assess utility for varying degrees of DC severity
Conclusion Various methods have been used at all stages of CSPBM development .
The choice between developing a classification system de novo or from an existing instrument may depend on the availability of a suitable existing measure , while the choice between a decomposed or composite approach appears to be determined primarily by the purpose for which the instrument is design ed .
Background Health state utility values ( HSUVs ) are required to calculate quality -adjusted life-years ( QALYs ) .
They are frequently derived from generic preference-based measures of health .
However , such generic measures may not capture health attributes of relevance to specific conditions .
In such cases , a condition-specific preference-based measure ( CSPBM ) may be more appropriate .
Objective This systematic review aim ed to identify all published accounts of developing CSPBMs to describe and appraise the methods used .