This meta- analysis shows that oral tibolone treatment significantly lowers circulating Lp(a ) levels in postmenopausal women .
INTRODUCTION Circulating lipoprotein ( a ) ( Lp(a ) ) is a recognized risk factor for cardiovascular disease ( CVD ) .
Tibolone , a synthetic steroid , may lower Lp(a ) levels ; however , evidence of the effects of tibolone on Lp(a ) still remain to be defined .
Therefore , we investigated the effects of tibolone treatment on circulating Lp(a ) levels in postmenopausal women .
Observational Study on the Efficacy of Tibolone in Counteracting Early Carotid Atherosclerotic Lesions in Postmenopausal Women
Objective : To study whether tibolone affects lipid profile and diffused intima media thickness ( IMT ) of the common carotid arteries ( CCA ) in postmenopausal women ( PMW ) . Methods : Twenty-two PMW and 20 premenopausal women participated in the study . The PMW were r and omly divided into 11 women who did not receive any treatment and 11 women who received tibolone ( 2.5 mg once a day ) . Results : After 6 months the treated women had lipoprotein(a ) ( Lpa ) , total-cholesterol ( total-C ) , and LDL-cholesterol ( LDL-C ) levels lower than before , while in the non-treated women Lpa was increased . The IMT of CCA was unmodified in the treated women , whereas it increased in non-treated women . Conclusions : This preliminary study suggests that a 6-month tibolone treatment could counteract the increase of the IMT of CCA observed in untreated PMW
This meta- analysis shows that oral tibolone treatment significantly lowers circulating Lp(a ) levels in postmenopausal women .
INTRODUCTION Circulating lipoprotein ( a ) ( Lp(a ) ) is a recognized risk factor for cardiovascular disease ( CVD ) .
Tibolone , a synthetic steroid , may lower Lp(a ) levels ; however , evidence of the effects of tibolone on Lp(a ) still remain to be defined .
Therefore , we investigated the effects of tibolone treatment on circulating Lp(a ) levels in postmenopausal women .