The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
[Effects of captopril on the cerebral blood flow in the hypertensive aged subjects].
Cerebral blood flow ( CBF ) was measured in 13 subjects ( 4 men and 9 women , mean age + /- SD = 63 + /- 7 ) with moderate , uncomplicated and untreated hypertension and 11 normotensive subjects ( 6 men and 5 women , mean age + /- SD = 66 + /- 5 ) . A second CBF measurement was performed in hypertensive subjects after a 60 days r and omized double blind treatment with either captopril , 75 mg a day ( n = 8) or placebo ( n = 5 ) . CBF was quantified using the 133Xe inhalation technic and 16 stationary detectors by hemisphere . Comparison of CBF values between hypertensive subjects before treatment and normotensive subjects demonstrated a decrease of CBF in the hypertensive group ( 49 + /- 9 vs 72 + /- 14 ml/100 g/min ; p < 0.001 ) . After the trial the results in the captopril group showed a significant fall in systolic ( p < 0.001 ) and diastolic ( p < 0.05 ) blood pressure and a significant increase in CBF ( 60 + /- 14 vs 49 + /- 11 ml/100 g/min ; p < 0.05 ) . In the placebo group there was no change in blood pressure and CBF ( Table ) . [ Table ; see text ] Our results demonstrate a decrease in CBF of uncomplicated and untreated elderly hypertensive subjects . This decrease is reversible under chronic treatment with captopril
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .