Based on the available evidence , motor evoked potentials at rest were the only biomarker that predicted motor outcome in individuals with severe arm impairment following stroke .
To build an underst and ing of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke , we conducted a pooled individual data systematic review to : 1 ) characterize brain biomarkers ; 2 ) determine relationship(s ) between biomarkers and motor outcome ; and 3 ) establish relationship(s ) between biomarkers and motor recovery .
Intermittent theta burst stimulation over ipsilesional primary motor cortex of subacute ischemic stroke patients: A pilot study
BACKGROUND We demonstrated that prolonged transcranial magnetic intermittent theta burst stimulation ( iTBS , 1200 pulses/session = iTBS1200 ) produces longer-lasting facilitation in corticospinal excitability than ordinary form of iTBS in healthy subjects . OBJECTIVE Here we show the safety and small-scale efficacy of iTBS1200 over ipsilesional primary motor cortex ( M1 ) in subacute stroke patients . METHODS Twelve patients with first-time , subacute ischemic stroke of the middle cerebral artery were r and omized into two groups that received 10 daily-sessions of either iTBS1200 or sham stimulation ( n=6/group ) over ipsilesional M1 h and region in addition to medical and rehabilitation treatments . The primary outcome measures were safety and tolerability . The secondary outcome measures included the National Institute of Health Stroke Scale ( NIHSS ) , Upper Extremity Fugl-Meyer Test ( UE-FMT ) , Action Research Arm Test ( ARAT ) , active motor thresholds (aMTs)/motor-evoked potentials ( MEPs ) from the extensor carpi radialis ( ECR ) , and magnetoencephalography on post-intervention day 1 and post-stroke day 60 . RESULTS iTBS or sham stimulation was well tolerated by all patients without seizures or significant adverse effects . Compared with the matched controls , the iTBS group showed measurable improvements in the NIHSS and the proximal UE-FMT scores on post-intervention day 1 and post-stroke day 60 . Nevertheless , the h and ARAT scores , aMT and MEPs from the paretic ECR were not different between groups . Post-movement beta synchronization increased over iTBS-conditioned M1 on post-intervention day 1 in testable patients . CONCLUSIONS Repetitive sessions of iTBS1200 over ipsilesional M1 of subacute stroke patients are safe and the potential benefits encourage a larger trial to determine the efficacy in stroke patients . ( Clinical Trials.gov : NCT-01323881 )
Based on the available evidence , motor evoked potentials at rest were the only biomarker that predicted motor outcome in individuals with severe arm impairment following stroke .
To build an underst and ing of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke , we conducted a pooled individual data systematic review to : 1 ) characterize brain biomarkers ; 2 ) determine relationship(s ) between biomarkers and motor outcome ; and 3 ) establish relationship(s ) between biomarkers and motor recovery .