Moreover , the changes in interleukin 6 concentration was dependent on study quality and intervention duration .
The current meta- analysis indicated that RS intake can improve some inflammatory biomarkers .
This study aim ed to summarize earlier studies on the effects of  RS consumption on the serum levels of inflammatory biomarkers .
Energy intake is associated with endotoxemia in apparently healthy men.
BACKGROUND The bridge between food intake and weight is not fully understood . Recently , the role of gut microbiota and bacterial lipopolysacharides ( LPS ) in weight has been noted . OBJECTIVE The objective was to evaluate the relation between plasma LPS concentration and food intake . DESIGN A dietary survey was conducted in 1015 subjects r and omly recruited in France . The participants were given oral and written instructions on how to keep a consecutive 3-d food record . Plasma LPS was measured in a sub sample of 201 men . To assess , under controlled conditions , the differential impact of various high-energy diets , plasma LPS concentrations were measured in mice fed a high-fat or a high-carbohydrate diet over a 4-wk period . RESULTS In humans , no significant relation was observed between cardiovascular disease risk factors , carbohydrate and protein intakes , and plasma LPS concentration . Conversely , positive correlations were observed with fat and energy intakes . In a multivariate analysis , endotoxemia was independently associated with energy intake . Compared with the control mice , mice fed a high-energy diet showed an increase in plasma LPS . However , in mice fed a high-carbohydrate diet , the increase in plasma LPS was blunted compared with mice fed a high-fat diet . CONCLUSIONS In this large sample of healthy men from a population -based sample , we found a link between food intake and plasma LPS . Experimental data suggest that fat was more efficient in transporting bacterial LPS from the gut lumen into the bloodstream . The results of this study add to the knowledge of mechanisms responsible for relations between food intake and metabolic diseases
Moreover , the changes in interleukin 6 concentration was dependent on study quality and intervention duration .
The current meta- analysis indicated that RS intake can improve some inflammatory biomarkers .
This study aim ed to summarize earlier studies on the effects of  RS consumption on the serum levels of inflammatory biomarkers .