Having this evidence s , the potential role of Carnitine in improving malnutrition consequences in CKD patients would be clearly defined
Protein energy malnutrition is a common problem in patients with chronic kidney disease ( CKD ) .
Scattered reports indicate that supplementation of Carnitine may improve patients ' clinical symptoms , with significant improvement in nutritional parameters .
This systematic review was done to document the evidence s of Carnitine effects in nutritional status of CKD patients .
Effects of Oral L-Carnitine Supplementation on Lipid Profile, Anemia, and Quality of Life in Chronic Renal Disease Patients under Hemodialysis: A Randomized, Double-Blinded, Placebo-Controlled Trial
In patients on maintenance hemodialysis several factors reduce the body stored carnitine which could lead to dyslipidemia , anemia , and general health in these patients . We evaluated the effect of oral L-carnitine supplementation on lipid profiles , anemia , and quality of life ( QOL ) in hemodialysis patients . In a r and omized , double-blinded , placebo-controlled trial , end-stage renal disease ( ESRD ) patients on hemodialysis received either L-carnitine 1 g/d ( n = 24 ) or placebo ( 27 patients ) for 16 weeks . At the end of the study , there was a significant decrease in triglyceride ( −31.1 ± 38.7 mg/dL , P = 0.001 ) and a significant increase in HDL ( 3.7 ± 2.8 mg/dL , P < 0.001 ) levels in the carnitine group . Decrease in total cholesterol ( −6.6 ± 16.0 mg/dL , P = 0.075 ) and increase in hemoglobin ( 0.7 ± 1.7 g/dL , P = 0.081 ) concentrations in the carnitine group were not significant . There was no statistically significant changes in LDL in any group ( P > 0.05 ) . Erythropoietin dose was significantly decreased in both the carnitine ( −4750 ± 5772 mg , P = 0.001 ) and the placebo group ( −2000 ± 4296 mg , P < 0.05 ) . No improvement was observed in QOL scores of two groups . In ESRD patients under maintenance hemodialysis  , oral L-carnitine supplementation may reduce triglyceride and cholesterol and increase HDL and hemoglobin and subsequently reduce needed erythropoietin dose without effect on QOL
Having this evidence s , the potential role of Carnitine in improving malnutrition consequences in CKD patients would be clearly defined
Protein energy malnutrition is a common problem in patients with chronic kidney disease ( CKD ) .
Scattered reports indicate that supplementation of Carnitine may improve patients ' clinical symptoms , with significant improvement in nutritional parameters .
This systematic review was done to document the evidence s of Carnitine effects in nutritional status of CKD patients .