Results of r and omized controlled trials performed to date provide evidence that antibiotic prophylaxis reduces subsequent infection and that courses as short as one day are as effective as courses of three to five days , although the evidence warrants only low to moderate confidence .
BACKGROUND The purpose of the present study was to perform a systematic review and meta- analysis of the use of alternative antibiotic regimens-including ( A ) antibiotic prophylaxis versus no prophylaxis , ( B ) longer versus shorter duration of antibiotic prophylaxis , and ( C ) alternative drugs-for  patients with open fracture of the extremities .
A Double‐Blind Clinical Trial of Prophylactic Cloxacillin in Open Fractures
In 100 patients with first- , second- , and third-degree open fractures , a r and omized , double-blind study was carried out to compare prophylactic cloxacillin and placebo . Prophylaxis was started preoperatively and continued for 10 days . The st and ard fracture treatment consisted of operative stabilization , mostly by means of plates or external fixators . In the cloxacillin group two infections were observed as compared to 12 in the control group . This difference was significant
Results of r and omized controlled trials performed to date provide evidence that antibiotic prophylaxis reduces subsequent infection and that courses as short as one day are as effective as courses of three to five days , although the evidence warrants only low to moderate confidence .
BACKGROUND The purpose of the present study was to perform a systematic review and meta- analysis of the use of alternative antibiotic regimens-including ( A ) antibiotic prophylaxis versus no prophylaxis , ( B ) longer versus shorter duration of antibiotic prophylaxis , and ( C ) alternative drugs-for  patients with open fracture of the extremities .