Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Does vitamin D3 supplementation improve glucose homeostasis in overweight or obese women? A double-blind, randomized, placebo-controlled clinical trial.
AIMS Vitamin D deficiency is considered as a risk factor in cardiometabolic disorders , including cardiovascular diseases , hypertension and Type 2 diabetes mellitus . We have investigated the effect of vitamin D3 supplementation on glucose homeostasis in healthy overweight and obese women . METHODS In a double-blind r and omized placebo-controlled clinical trial , 77 healthy overweight or obese women ( mean age 38 ± 8 years ; BMI 29.9 ± 4.2 kg/m(2 ) ) were r and omly assigned to the vitamin D3 group ( 25 μg/day as cholecalciferol tablets ) or the placebo group  . Selected anthropometric indices , glucose , insulin , HbA(1c ) and homeostasis model assessment of insulin resistance at baseline and after 12 weeks were measured . Dietary intakes using 24-h food recall and food frequency question naires were assessed . Physical activity was assessed by the International Physical Activity Question naire . Adjusted mean differences were calculated using analysis of covariance . Correlation coefficients were calculated by Pearson 's analysis . RESULTS Mean fasting blood glucose concentrations declined in the vitamin D3 and placebo groups ( -0.28 ± 0.4 vs. -0.65 ± 0.4 mmol/l , P < 0.001 ) and the mean percentage of HbA(1c ) was decreased ( -13 ± 18 vs. -19 ± 17 mmol/l , P = 0.06 ) in both groups , respectively . Mean 25-hydroxyvitamin D concentrations increased in the vitamin D3 and placebo groups ( 38.2 ± 32 vs. 4.6 ± 14 nmol/l , P < 0.001 ) , respectively . There was a significant correlation between HbA(1c ) and 25-hydroxyvitamin D concentrations ( r = -0.271 ; P = 0.018 ) . CONCLUSIONS The results indicate that the vitamin D3 supplement of 25 μg/day had no beneficial effect on glycaemic indices in healthy overweight or obese women
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .