The present review demonstrates that vitamin D supplementation result ed in small but nonsignificant improvements in muscle strength compared to control in postmenopausal women .
No significant effect was observed in mobility after vitamin D administration
BACKGROUND The results obtained from previous trials regarding the effects of vitamin D supplementation on muscle strength and mobility  in postmenopausal women have been inconsistent .
This systematic review and meta- analysis of r and omised controlled trials ( RCTs ) aim ed to investigate the effect of vitamin D supplementation on muscle strength and mobility in postmenopausal women .
Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity.
To test the effect of 25(OH)D(3 ) ( HyD ) compared to vitamin D(3 )  on serum 25-hydroxyvitamin D levels ( 25(OH)D ) , lower extremity function , blood pressure , and markers of innate immunity . Twenty healthy postmenopausal women with an average 25(OH)D level of 13.2 ± 3.9 ng/mL ( mean ± SD ) and a mean age of 61.5 ± 7.2 years were r and omized to either 20 µg of HyD or 20 µg ( 800 IU ) of vitamin D(3 ) per day in a double-blind manner . We measured on 14 visits over 4 months , 25(OH)D serum levels , blood pressure , and seven markers of innate immunity ( eotaxin , interleukin [IL]-8 , IL-12 , interferon gamma-induced protein 10 kDa [ IP-10 ] , monocyte chemotactic protein-1 [ MCP-1 ] , macrophage inflammatory protein beta [ MIP-1β ] , and " Regulated upon Activation , Normal T-cell Expressed , and Secreted " [ RANTES ] ) . At baseline and at 4 months , a test battery for lower extremity function ( knee extensor and flexor strength , timed up and go , repeated sit-to-st and ) was assessed . All analyses were adjusted for baseline measurement , age , and body mass index . Mean 25(OH)D levels increased to 69.5 ng/mL in the HyD group . This rise was immediate and sustained . Mean 25(OH)D levels increased to 31.0 ng/mL with a slow increase in the vitamin D(3 ) group . Women on HyD compared with vitamin D(3 ) had a 2.8-fold increased odds of maintained or improved lower extremity function ( odds ratio [ OR ] = 2.79 ; 95 % confidence interval [ CI ] , 1.18 - 6.58 ) , and a 5.7-mmHg decrease in systolic blood pressure ( p = 0.0002 ) . Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity , significantly more pronounced with HyD for eotaxin , IL-12 , MCP-1 , and MIP-1 β . There were no cases of hypercalcemia at any time point . Twenty micrograms ( 20 µg ) of HyD per day result ed in a safe , immediate , and sustained increase in 25(OH)D serum levels in all participants , which may explain its significant benefit on lower extremity function , systolic blood pressure , and innate immune response compared with vitamin D(3 )
The present review demonstrates that vitamin D supplementation result ed in small but nonsignificant improvements in muscle strength compared to control in postmenopausal women .
No significant effect was observed in mobility after vitamin D administration
BACKGROUND The results obtained from previous trials regarding the effects of vitamin D supplementation on muscle strength and mobility  in postmenopausal women have been inconsistent .
This systematic review and meta- analysis of r and omised controlled trials ( RCTs ) aim ed to investigate the effect of vitamin D supplementation on muscle strength and mobility in postmenopausal women .