LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .
Effects of morning versus evening administration of atorvastatin in patients with hyperlipidemia.
PURPOSE The effects of morning versus evening administration of atorvastatin in hyperlipidemic patients were studied . METHODS Patients whose care was managed by a teaching hospital run by the Department of Veterans Affairs who were prescribed atorvastatin calcium 40 mg p.o . daily by their primary care physician were interviewed by a clinical pharmacist in the ambulatory care clinic for study enrollment . Patients were excluded if they had diseases or conditions or took medication known to affect serum lipoprotein levels , as were patients who consumed more than three alcoholic drinks per day and those who could not verify the time of atorvastatin administration . Blood sample s were collected after a 12-hour fasting period and serum lipoprotein levels were measured at baseline and after four weeks . RESULTS Of the 204 hyperlipidemic patients receiving atorvastatin , 64 met the inclusion criteria and were enrolled in the study , 32 of whom took the drug in the morning ( before noon ) and an equal number who took the drug at night ( after 6 p.m. but before midnight ) . All patients were male out patients with a mean + /- S.D. age of 57.8 + /- 7.8 years and 58.5 + /- 7.8 years for the morning and evening administration groups , respectively . No statistically significant differences in lipid values measured were found between the morning and evening administration group after four weeks . CONCLUSION Changes in the levels of total cholesterol , low-density-lipoprotein cholesterol , triglycerides , and high-density-lipoprotein cholesterol were similar among hyperlipidemic patients receiving atorvastatin calcium 40 mg , regardless of the time of day the drug was administered
LDL-C and TC lowering was significantly greater in the evening dose than in the morning dose in case of short-acting statins .
Besides slight but significant effect on LDL-C , the efficacy of long-acting statins was equivalent for both regimens .
BACKGROUND Evidence about the optimal time of day at which to administer statins is lacking .
OBJECTIVE The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile .