CLINICAL IMPLICATION S Only SCORAD , EASI , and POEM currently perform adequately .
BACKGROUND Valid and reliable outcome measurements are a prerequisite for evidence -based practice .
The comparative validity and reliability of outcome measurements for assessing atopic eczema ( AE ) severity is unclear .
OBJECTIVE We sought to assess the validity , reliability , sensitivity to change , and ease of use of outcome measurements for AE .
We also sought to give recommendations on which outcomes to use in clinical research and for clinical monitoring .
Symptomatology and growth in infants with cow's milk protein intolerance using two different whey-protein hydrolysate based formulas in a Primary Health Care setting.
Both growth and the course of allergic symptoms were evaluated in 79 infants with cow 's milk protein intolerance , aged three months or younger , diagnosed by st and ard elimination/provocation and treated with a whey-hydrolysate based infant formula : Nutrilon Pept or Pepti Junior .  The efficacy of both products , in terms of symptomatology and growth , was compared with each other . The products differ in fat source ( Pepti Junior 50 % of its fat as MCT , Nutrilon Pepti normal LCT fat blend ) and the presence of lactose ( Pepti Junior : lactose free ; Nutrilon Pepti : 40 % of its carbohydrate as lactose ) . The study was part of a large project that aim ed at st and ardising the approach towards cow 's milk protein intolerance in Baby Health Clinics . Nearly 50 Baby Health Clinics participated in this project . In this study , growth and symptomatology ( skin , respiratory tract , gastrointestinal tract ) were monitored during an intervention period of at least 10 weeks . Infants in both feeding groups showed normal growth , and in at least 80 % of the infants an improvement of the overall symptomatology could be seen during the intervention period . Most profound were the decreases in prevalence and severity of eczema and infantile colic . No differences in efficacy were found in this study between the two infant formulas . It was concluded that the exclusive use of either whey hydrolysate based infant formula result ed in an improvement of allergic symptoms and in normal growth in infants diagnosed by elimination/provocation for cow 's milk protein intolerance in a Primary Health Care setting
CLINICAL IMPLICATION S Only SCORAD , EASI , and POEM currently perform adequately .
BACKGROUND Valid and reliable outcome measurements are a prerequisite for evidence -based practice .
The comparative validity and reliability of outcome measurements for assessing atopic eczema ( AE ) severity is unclear .
OBJECTIVE We sought to assess the validity , reliability , sensitivity to change , and ease of use of outcome measurements for AE .
We also sought to give recommendations on which outcomes to use in clinical research and for clinical monitoring .