Multiple secondary data analyses of TORDIA have identified important predictors of treatment response and relapse .
To up date a comparative effectiveness review ( 1980–2011 ) of treatments for adolescents whose depressive episode or disorder ( MDE/MDD ) did not respond to one or more trials of SSRI antidepressants .
The bi-directional relationship between parent-child conflict and treatment outcome in treatment-resistant adolescent depression.
OBJECTIVE To examine the bidirectional relationship between parent-child discord and treatment outcome for adolescent treatment-resistant depression . METHOD Depressed youth who had not responded to an adequate course of a selective serotonin reuptake inhibitor ( SSRI )  were r and omized to either a switch to another SSRI or venlafaxine , with or without the addition of cognitive behavior therapy ( CBT ) in the Treatment of SSRI-Resistant Depression in Adolescents ( TORDIA ) study . The Conflict Behavior Question naire was used to assess  adolescent ( CBQ-A )  and parent-reported ( CBQ-P ) parent-child  discord . The impact of remission on parent-child conflict , and the differential impact of medication and CBT on the CBQ-A and CBQ-P , were assessed using generalized linear models . RESULTS Although there were no differential treatment effects on parent or adolescent-report of conflict , remission was associated with improvement in the CBQ-P. In general , intake family conflict did not predict remission , except in the sub-group of participants whose parents reported clinical ly significant  parent-child  conflict at intake , for whom high levels of parent-reported conflict predicted a lower likelihood of remission . Conflict also did not moderate treatment response . CONCLUSIONS Remission of depression may be sufficient to reduce parent-reported parent-child conflict . However , higher parent-reported conflict , in the clinical ly significant range , predicts a lower likelihood of remission from depression . Clinical trial registration information-Treatment of SSRI-Resistant Depression in Adolescents ( TORDIA ) ; http:// clinical trials.gov/ ; NCT00018902
Multiple secondary data analyses of TORDIA have identified important predictors of treatment response and relapse .
To up date a comparative effectiveness review ( 1980–2011 ) of treatments for adolescents whose depressive episode or disorder ( MDE/MDD ) did not respond to one or more trials of SSRI antidepressants .