No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .
Low-concentration homogenized castor oil eye drops for noninflamed obstructive meibomian gland dysfunction.
OBJECTIVE We developed low-concentration homogenized castor oil eye drops for the treatment of patients with noninflamed obstructive meibomian gl and dysfunction ( MGD ) , a major cause of lipid-deficiency dry eye , and assessed the safety , stability , and efficacy of the eye drops . DESIGN R and omized , double-masked , placebo-controlled crossover clinical trial . PARTICIPANTS Forty eyes of 20 patients with noninflamed MGD . METHODS After a preliminary study of eye drops containing castor oil , 2 % castor oil and 5 % polyoxyethylene castor oil ( emulsifier ) were mixed to formulate homogenized oil eye drops . The patients were assigned r and omly to receive oil eye drops or placebo six times daily for 2 periods of 2 weeks each . MAIN OUTCOME MEASURES At the end of each treatment period , we assessed symptoms , tear interference grade , tear evaporation , fluorescein and rose bengal scores , tear break-up time ( BUT ) , and meibomian gl and orifice obstruction . Safety and stability tests were also performed . RESULTS Symptom scores , tear interference grade , tear evaporation test results , rose bengal scores , tear BUT , and orifice obstruction scores after the oil eye drop period showed significant improvement compared with the results after the placebo period . No complications attributable to the eye drops were observed . The oil eye drops were stable when stored at 4 degrees C. CONCLUSIONS The results indicate that castor oil eye drops are effective and safe in the treatment of MGD . The possible mechanisms of this treatment are improvement of tear stability as a result of lipid spreading , ease of meibum expression , prevention of tear evaporation , and the lubricating effect of the oil eye drops
No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .