In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .
Treatment of infrabony defects with or without enamel matrix proteins: a 24-month follow-up randomized pilot study.
OBJECTIVE To evaluate a comparison of open-flap debridement ( OFD ) with or without the use of enamel matrix proteins ( EMP ) for the treatment of infrabony defects . METHOD AND MATERIAL S Ten volunteers ( 38 infrabony defects ) were r and omized to receive OFD+EMP ( test site ) and OFD ( control site ) . Clinical outcomes included mean changes in Plaque Index , Gingival Index , probing pocket depth ( PPD ) , relative attachment level ( RAL ) , gingival recession , width of keratinized tissue , and dental mobility at baseline and at 24 months . RESULTS A significant reduction of 4.21+/-0.97 mm was observed in PPD for the OFD+EMP group ( from 6.30+/-0.99 mm to 2.09+/-0.97 mm ) and of 3.28+/-1.23 mm for the OFD group ( from 6.13+/-0.88 mm to 2.85+/-1.42 mm ) ( P<.001 ) . The reduction in PPD was statistically significantly greater for OFD+EMP compared to OFD ( P=.03 ) . The mean RAL decreased from 13.26+/-1.88 mm to 7.57+/-2.05 mm for the OFD+EMP group ( a gain of 5.69+/-1.96 mm ) and from 13.37+/-1.71 mm to 8.13+/-1.34 mm ( P<.001 ) for the OFD group ( a gain of 5.24+/-1.55 mm ) . Gingival recession was higher in the OFD+EMP group than in the OFD group . The mean keratinized tissue significantly decreased from 4.41+/-1.39 mm to 3.63+/-1.54 mm for OFD flap group ( P<.01 ) . CONCLUSION Both treatment modalities were efficient in improving RAL and PPD . Within groups , there was a significant reduction in keratinized tissue for OFD and a significant postoperative recession for the OFD + EMP group . Infrabony defects treated with OFD + EMP showed significantly more PPD reduction when compared to OFD
In conclusion , follow-up time ( < or > 2 years ) and the risk of bias influence the results of treatment with EMDP in IPD
Previous systematic review s have demonstrated better results with enamel matrix derivative proteins ( EMDP ) as compared with open flap debridement ( OFD ) for the management of infrabony periodontal defects ( IPD ) .
The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies .