Combining 21 trials evaluating lipid outcomes , fish oil consumption result ed in a summary net change in triglycerides of -27 ( 95 % CI -33 , -20)mg/dL , in HDL cholesterol of + 1.6 ( 95 % CI + 0.8 , + 2.3)mg/dL , and in LDL cholesterol of + 6 ( 95 % CI + 3 , + 8)mg/dL. There was no effect of fish oil on total cholesterol .
Across studies , higher fish oil dose and higher baseline levels were associated with greater reductions in serum triglycerides .
The evidence supports a dose-dependent beneficial effect of fish oil on serum triglycerides , particularly among people with more elevated levels .
Fish oil consumption also modestly improves HDL cholesterol , increases LDL cholesterol levels , but does not appear to adversely affect glucose homeostasis .
The evidence regarding the effects of omega-3 fatty acids on hs-CRP is inconclusive , as are data on ALA
Greater fish oil consumption has been associated with reduced CVD risk , although the mechanisms are unclear .
Plant- source oil omega-3 fatty acids ( ALA ) have also been studied regarding their cardiovascular effect .
Effects of a new fish oil concentrate on plasma lipids and lipoproteins in patients with hypertriglyceridaemia.
OBJECTIVES The effect of a fish oil preparation , K-85 , in which the omega-3 fatty acid content was concentrated to 92 % of total fat , on serum lipid and lipoprotein concentrations was investigated in patients with primary hypertriglyceridaemia . DESIGN The study was a r and omized , double-blind , placebo-controlled study . SETTING Seven centres participated in the study , five secondary referral centres and two general practice s. SUBJECTS Men and women aged 18 - 70 years with fasting serum triglyceride concentrations between 2 and 10 mmol/l and fasting serum cholesterol concentrations > 5.2 mmol/l were studied . Patients with diabetes mellitus , hypothyroidism , serious illness in the previous 3 months or severe concurrent illness were excluded from the study , as were drug or alcohol abusers and pregnant and lactating women . Ninety-five subjects entered the study , 79 completed the study . INTERVENTIONS Patients were r and omized to receive K-85 2 g twice daily or corn oil 2 g twice daily for 14 weeks . MAIN OUTCOME MEASUREMENTS The serum concentrations of triglycerides and cholesterol , very low-density lipoprotein ( VLDL ) , low-density lipoprotein ( LDL ) , high-density lipoprotein ( HDL ) and lipoprotein ( a ) . Fasting blood glucose and blood pressure . RESULTS Serum triglycerides and VLDL-cholesterol were significantly lower in the group treated with K-85 than in the placebo group after 6 , 10 and 14 weeks ( all P < 0.01 ) and there was a decrease in the serum triglyceride concentration from 3.99 ( 2.94 - 9.47 ) to 2.87 ( 1.2 - 9.93 ) mmol/l ( P < 0.001 ) and in VLDL-cholesterol from 1.47 ( 0.77 - 3.63 ) to 1.12 ( 0.21 - 3.67 ) mmol/l ( P < 0.01 ) in patients receiving K-85 .  Serum HDL-cholesterol increased from 0.98 ( 0.95 - 1.01 ) to 1.11 ( 1.07 - 1.15 ) mmol/l ( P < 0.01 ) in the patients with type IV hyperlipoproteinaemia but did not change in those with type IIb . Serum LDL-cholesterol , lipoprotein ( a ) and fasting blood glucose were unaffected by K-85 .  Diastolic blood pressure decreased from 86 + /- 11 to 80 + /- 12 mmHg ( P < 0.02 ) and was also lower than in the placebo group ( P < 0.05 ) . The corn oil placebo did not affect any of the parameters . CONCLUSION K-85 is effective in lowering serum triglycerides and VLDL in patients with primary hypertriglyceridaemia and may have utility as a triglyceride-lowering agent
Combining 21 trials evaluating lipid outcomes , fish oil consumption result ed in a summary net change in triglycerides of -27 ( 95 % CI -33 , -20)mg/dL , in HDL cholesterol of + 1.6 ( 95 % CI + 0.8 , + 2.3)mg/dL , and in LDL cholesterol of + 6 ( 95 % CI + 3 , + 8)mg/dL. There was no effect of fish oil on total cholesterol .
Across studies , higher fish oil dose and higher baseline levels were associated with greater reductions in serum triglycerides .
The evidence supports a dose-dependent beneficial effect of fish oil on serum triglycerides , particularly among people with more elevated levels .
Fish oil consumption also modestly improves HDL cholesterol , increases LDL cholesterol levels , but does not appear to adversely affect glucose homeostasis .
The evidence regarding the effects of omega-3 fatty acids on hs-CRP is inconclusive , as are data on ALA
Greater fish oil consumption has been associated with reduced CVD risk , although the mechanisms are unclear .
Plant- source oil omega-3 fatty acids ( ALA ) have also been studied regarding their cardiovascular effect .