Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D.
CONTEXT Two reports suggested that vitamin D2 is less effective than vitamin D3 in maintaining vitamin D status . OBJECTIVE Our objective was to determine whether vitamin D2 was less effective than vitamin D3 in maintaining serum 25-hydroxyvitamin D levels or increased the catabolism of 25-hydroxyvitamin D3 . SUBJECTS AND DESIGN This was a r and omized , placebo-controlled , double-blinded study of healthy adults ages 18 - 84 yr who received placebo , 1000 IU vitamin D3 , 1000 IU vitamin D2 , or 500 IU vitamin D2 plus 500 IU vitamin D3 daily for 11 wk at the end of the winter . RESULTS Sixty percent of the healthy adults were vitamin D deficient at the start of the study . The circulating levels of 25-hydroxyvitamin D ( mean+/-sd ) increased to the same extent in the groups that received 1000 IU daily as vitamin D2 ( baseline 16.9+/-10.5 ng/ml ; 11 wk 26.8+/-9.6 ng/ml ) , vitamin D3 ( baseline 19.6+/-11.1 ng/ml ; 11 wk 28.9+/-11.0 ng/ml ) , or a combination of 500 IU vitamin D2 and 500 IU vitamin D3 ( baseline 20.2+/-10.4 ng/ml ; 11 wk 28.4+/-7.7 ng/ml ) . The 25-hydroxyvitamin D3 levels did not change in the group that received 1000 IU vitamin D2 daily . The 1000 IU dose of vitamin D2 or vitamin D3 did not raise 25-hydroxyvitamin D levels in vitamin D-deficient subjects above 30 ng/ml . CONCLUSION A 1000 IU dose of vitamin D2 daily was as effective as 1000 IU vitamin D3 in maintaining serum 25-hydroxyvitamin D levels and did not negatively influence serum 25-hydroxyvitamin D3 levels . Therefore , vitamin D2 is equally as effective as vitamin D3 in maintaining 25-hydroxyvitamin D status
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .