AUTHORS ' CONCLUSIONS Addition of ox and rolone to the GH therapy led to a modest increase in the final adult height of girls aged up to 18 years with TS .
BACKGROUND The final adult height of untreated girls aged up to 18 years with Turner syndrome ( TS ) is approximately 20 cm shorter compared with healthy females .
Treatment with growth hormone ( GH ) increases the adult height of people with TS .
The effects of adding the and rogen , ox and rolone , in addition to GH are unclear .
Therefore , we conducted this systematic review to investigate the benefits and harms of ox and rolone as an adjuvant therapy for people with TS treated with GH .
OBJECTIVES To assess the effects of ox and rolone on growth hormone-treated girls aged up to 18 years with Turner syndrome .
Self-esteem and social adjustment in young women with Turner syndrome--influence of pubertal management and sexuality: population-based cohort study.
CONTEXT Pediatric management of patients with Turner syndrome focuses on height , frequently result ing in a delay of pubertal induction . The influence of pubertal management on psychosocial adjustment and sex life has not been evaluated in Turner syndrome patients . OBJECTIVE The objective of the study was to identify the determinants of self-esteem , social adjustment , and initiation of sex life in patients with Turner syndrome , particularly those related to pubertal management . DESIGN This was a prospect i ve evaluation , the StaTur study . SETTING The study was conducted with a population -based registry of GH-treated patients . PARTICIPANTS Participants included 566 young adult women with Turner syndrome , aged 22.6 + /- 2.6 yr ( range , 18.3 - 31.2 ) . MAIN OUTCOME MEASURES Measures used in the study were Coopersmith 's Self-Esteem Inventory , Social Adjustment Scale Self-Report , questions on sexual experience , and extensive data on pediatric management . RESULTS Low self-esteem was associated with otological involvement and limited sexual experience . Low social adjustment was associated with lower paternal socioeconomic class and an absence of sexual experience . Late age at first kiss or date was associated with cardiac involvement and a lack of spontaneous pubertal development . Age at first sexual intercourse was related to age at puberty and paternal socioeconomic class . Delayed induction of puberty had a long-lasting effect on sex life . Height and height gain due to GH treatment had no effect on outcomes . CONCLUSIONS Puberty should be induced at a physiologically appropriate age in patients with Turner syndrome to optimize self-esteem , social adjustment , and initiation of the patient 's sex life . Therapeutic interventions altering normal pubertal development in other groups of patients should be reconsidered in light of these findings
AUTHORS ' CONCLUSIONS Addition of ox and rolone to the GH therapy led to a modest increase in the final adult height of girls aged up to 18 years with TS .
BACKGROUND The final adult height of untreated girls aged up to 18 years with Turner syndrome ( TS ) is approximately 20 cm shorter compared with healthy females .
Treatment with growth hormone ( GH ) increases the adult height of people with TS .
The effects of adding the and rogen , ox and rolone , in addition to GH are unclear .
Therefore , we conducted this systematic review to investigate the benefits and harms of ox and rolone as an adjuvant therapy for people with TS treated with GH .
OBJECTIVES To assess the effects of ox and rolone on growth hormone-treated girls aged up to 18 years with Turner syndrome .