REVIEW ER 'S CONCLUSIONS There is no evidence to support feeding with a hydrolysed formula for the prevention of allergy in preference to exclusive breast feeding .
In high risk infants who are unable to be completely breast fed , there is evidence that prolonged feeding with a hydrolysed compared to a cow 's milk formula reduces infant and childhood allergy and infant CMA .
BACKGROUND Allergies and food reactions are common and may be associated with foods including adapted cow 's milk formulas .
Formulas containing hydrolysed proteins have been used to treat infants with allergy or food intolerance , and have been advocated for prevention of allergy and food intolerance in infants .
OBJECTIVES To determine whether use of hydrolysed formulas for infant feeding prevents allergy and food intolerance .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective including extensively and partially hydrolysed formulas .
To determine which infants benefit including infants at low or high risk of allergy and infants receiving early , short term or prolonged formula feeding .
Development of nasal basophilic cells and nasal eosinophils from age 4 months through 4 years in children of atopic parents.
BACKGROUND The importance of the inflammatory response in allergic disease has warranted investigation of two of the more integral cells in the pathogenesis of allergic rhinitis , namely , nasal basophilic cells ( NBCs ) and nasal eosinophils ( NEs ) . In the present study the natural history of NBCs and NEs was studied from birth through 4 years of age in infants of atopic parents to better underst and their relationship to the development of various atopic disorders . METHODS During a prospect i ve , r and omized , controlled trial of the effect of maternal and infant food avoidance on the development of atopic disorders in 288 infants of atopic parents , NBCs and NEs were determined semiquantitatively on Wright-Geimsa stained nasal mucosal scrapings and related to each other and to various atopic parameters . RESULTS In these infants who are at high risk NBCs developed in both those becoming atopic and those remaining nonatopic , but they occurred with increased frequency and quantity in those children in whom most allergic disorders and food or inhalant sensitization developed . NEs , rare at 4 months in all infants , increased in atopic children from 1 to 4 years , and remained infrequent and nominal in nonatopic children . Levels of NBCs and NEs ( 1 ) correlated with each other strongly , directly , and with increasing magnitude in children from ages 4 months to 4 years and ( 2 ) correlated with log serum IgE levels weakly and moderately in children from ages 2 to 4 years . Stepwise linear regression analyses revealed that allergic rhinitis accounted for most of the variance seen in the level of NBCs and NEs during early childhood , reaching 50 % by age 4 years . Asthma , atopic dermatitis , food allergy , food and inhalant sensitization , serum IgE level , and IgG beta-lactoglobulin level accounted for a small proportion of the variance in NBCs and NEs from ages 4 months to 4 years . CONCLUSIONS These findings help to eluci date the natural history of NBCs and NEs in infants at risk for atopic disorders and document the temporal association of these cells with the development of atopic disease , principally allergic rhinitis
REVIEW ER 'S CONCLUSIONS There is no evidence to support feeding with a hydrolysed formula for the prevention of allergy in preference to exclusive breast feeding .
In high risk infants who are unable to be completely breast fed , there is evidence that prolonged feeding with a hydrolysed compared to a cow 's milk formula reduces infant and childhood allergy and infant CMA .
BACKGROUND Allergies and food reactions are common and may be associated with foods including adapted cow 's milk formulas .
Formulas containing hydrolysed proteins have been used to treat infants with allergy or food intolerance , and have been advocated for prevention of allergy and food intolerance in infants .
OBJECTIVES To determine whether use of hydrolysed formulas for infant feeding prevents allergy and food intolerance .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective including extensively and partially hydrolysed formulas .
To determine which infants benefit including infants at low or high risk of allergy and infants receiving early , short term or prolonged formula feeding .