No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .
Efficacy of topical cyclosporin 0.05% in the treatment of posterior blepharitis.
We assessed the efficacy of topical cyclosporin 0.05 % ophthalmic emulsion versus tobramycin 0.3%/dexamethasone 0.1 % in patients with posterior blepharitis .  Posterior blepharitis improved significantly from the initial study visit with both cyclosporin treatment and tobramycin/dexamethasone . Cyclosporin provided greater improvements in Schirmer 's scores ( P < 0.001 ) and tear break-up time ( P = 0.018 ) than tobramycin/dexamethasone after 12 weeks of treatment . Eyelid health also improved in both groups , but the mean improvement in meibomian gl and secretion quality was significantly greater with cyclosporin than with tobramycin/dexamethasone ( P = 0.015 ) . Moreover , a higher percentage of patients in the cyclosporin treatment group had improvements in symptoms of blurred vision , burning , and itching and more cyclosporin-treated patients experienced resolution of lid telangiectasia . The findings in this prospect i ve study suggest that posterior blepharitis can be more effectively treated with cyclosporin than with tobramycin/dexamethasone . These findings should be further evaluated in large-scale , controlled , clinical trials
No quantitative synthesis was attempted for either mebiomian plugging or meibomian secretion scores and no significant changes were observed with any other outcome parameter .
Conclusion : Only the systemic antimicrobials were found to improve the clinical features of meibomian gl and dysfunction .
Varying effects of different therapeutic agents ( heat therapies , omega-3-fatty acids and castor oil ) were identified for MGD but the risk of bias pertaining to r and omization and allocation concealment was found to be associated with most of the current RCTs .
Introduction : Meibomian Gl and Dysfunction ( MGD ) is a common , often overlooked , chronic condition affecting eyes for which various therapies are being evaluated .
Considering the absence of a systematic review and meta- analysis , the present review was carried out .