There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .
Docosahexaenoic Acid Status of Term Infants Fed Breast Milk or Infant Formula Containing Soy Oil or Corn Oil
ABSTRACT : The objective of this study was to compare circulating lipid docosahexaenoic acid [ 22:6(n-3 ) , DHA ] levels in term infants fed a powdered ( CORN oil ) or liquid ( SOY oil ) infant formula or human milk ( HM ) . Infants whose mothers chose not to breast feed were r and omly assigned to the CORN or SOY formula group . The formula fat differed in linolenic acid [ 18:3(n-3 ) ] content : it was 0.8 % for the CORN and 4.8 % for the SOY . Linoleic acid ( 18:2(n-6 ) ] was 31.5 and 34.2 % fatty acids in the CORN and SOY formula , respectively . The formulas or HM were fed from birth through 8 wk of age , and growth and the plasma and red blood cell ( RBC ) phospholipid fatty acid composition was determined at 3 d , 4 wk , and 8 wk of age . Growth did not differ among groups . The plasma phospholipid and RBC phosphatidylethanolamine DHA was similar in the CORN and SOY formula groups at all ages . Plasma and RBC phosphatidylethanolamine levels of DHA were significantly lower in infants fed the CORN or SOY formula than in infants fed HM during wk 4 and 8 . Plasma and RBC 22:5(n-6 ) was not increased in the formula groups at any age . The formula content of linolenic acid had no effect on the RBC or plasma DHA levels of the infants . The biologic or functional significance of the lower plasma and RBC DHA in infants fed formula rather than HM is unknown . The need for a dietary source of DHA and specificity of plasma or RBC phospholipid DHA as a measure of desaturation and elongation of linolenic acid in developing organs remains uncertain
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy , asthma , dermatitis/eczema or food allergy .
However , the quality of evidence was very low .
There was insufficient evidence to determine an effect on allergic rhinitis
BACKGROUND Early dietary intakes may influence the development of allergic disease .
It is important to determine if dietary polyunsaturated fatty acids ( PUFAs ) given as supplements or added to infant formula prevent the development of allergy .
OBJECTIVES To determine the effect of higher PUFA intake during infancy to prevent allergic disease .