On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .
Double-blind, placebo-controlled study of single-dose amphetamine formulations in ADHD.
OBJECTIVE To compare the efficacy and time course of single morning doses of Adderall , extended-release , and immediate-release dextroamphetamine sulfate . METHOD Thirty-five children with attention-deficit/hyperactivity disorder , combined type , were given Adderall , immediate-release dextroamphetamine , dextroamphetamine Spansules , and placebo in a r and omized , double-blind , crossover study . Behavior ratings , locomotor activity measurements , and academic measures were obtained over a period of 8 weeks . RESULTS All three drugs exhibited robust efficacy versus placebo on nearly all measures . The effects of dextroamphetamine Spansules were less robust in the morning , particularly compared with Adderall , but they lasted 3 to 6 hours longer , depending on the measure . Although parent behavior ratings and locomotor activity showed improvements up to 12 hours after single doses of all three drugs , the number of math problems attempted and completed correctly 4 hours after dosing were only robustly increased by Spansules . CONCLUSIONS Both immediate-release amphetamines demonstrated earlier onset of effects , but dextroamphetamine Spansules showed more sustained effects that were present on a wider range of measures
On the CGI-I scale , the analysis revealed that MPH was more effective than ATX and GXR .
For any adverse events , RBX ( 89 % ) was the safest alternative .
Network meta- analysis offered a broader overview on the available treatments for ADHD , especially for safety issues , and contributes towards evidence gathering and clinical practice decisions .
The aim of this study is to gather evidence of head-to-head double-blind r and omized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder ( ADHD ) in children and adolescents .