Conclusion Probiotic supplementation seemed to be able to reduce the risk of a newborn 's hyperbilirubinemia and improve glycemic control , blood lipid profiles and inflammation and oxidative stress in pregnant women with GDM .
Background Previous studies showed that probiotics could improve glycemic control and attenuate some of the adverse effects of type 2 diabetes .
However , whether the effects are generalizable to gestational diabetes mellitus ( GDM ) remains uncertain .
Objective We conducted a systematic review and meta- analysis to evaluate the effects of probiotic supplement in GDM .
Perinatal sclerostin concentrations in abnormal fetal growth: the impact of gestational diabetes
Abstract Objective : To prospect ively evaluate maternal and cord blood concentrations of sclerostin – an osteocyte-secreted factor , inhibiting osteoblast differentiation and bone formation and associated with adverse metabolism – in pregnancies with normal and abnormal fetal growth . Methods : Plasma sclerostin concentrations were determined by ELISA in 80 maternal and 80 cord blood sample s from asymmetric intrauterine-growth-restricted ( IUGR , n = 30 ) , large-for-gestational-age ( LGA , n = 30 ) , and appropriate-for-gestational-age ( AGA , n = 20 ) singleton full-term pregnancies . Fourteen out of 30 mothers with LGA offspring presented with gestational diabetes mellitus ( GDM ) . Results : Maternal and fetal sclerostin concentrations did not differ among LGA , IUGR , and AGA groups . Fetal concentrations were higher than maternal . In LGA group , maternal concentrations were elevated in cases of GDM ( b = 13.009 , 95%CI 1.425–24.593 , p = .029 ) . In a combined group and the IUGR  group , maternal concentrations were elevated in older mothers ( b = 0.788 , 95%CI 0.190–1.385 , p = .010 , and b = 0.740 , 95%CI 0.042–1.438 , p = .039 , respectively ) . Conclusions : Maternal and fetal sclerostin concentrations may not be differentially regulated in pregnancies complicated by abnormal fetal growth . Circulating maternal levels are higher in cases of GDM , probably implying reduced bone formation . Sclerostin up-regulation with aging may be one of the molecular pathways responsible for the observed age-related decline in bone synthesis , leading to accelerated bone loss in humans
Conclusion Probiotic supplementation seemed to be able to reduce the risk of a newborn 's hyperbilirubinemia and improve glycemic control , blood lipid profiles and inflammation and oxidative stress in pregnant women with GDM .
Background Previous studies showed that probiotics could improve glycemic control and attenuate some of the adverse effects of type 2 diabetes .
However , whether the effects are generalizable to gestational diabetes mellitus ( GDM ) remains uncertain .
Objective We conducted a systematic review and meta- analysis to evaluate the effects of probiotic supplement in GDM .