In conclusion , statins were effective in preventing postoperative adhesion , as assessed based on gross and microscopic adhesion scores in rats
Adhesion is a significant concern after surgery .
Many research ers studied the anti-adhesive effect of statin , of which results were inconsistent .
Thus , we purpose d to perform a systematic review and meta- analysis to evaluate the effect of statins on postoperative adhesion in an experimental study .
Attenuation in peripheral endothelial function after continuous flow left ventricular assist device therapy is associated with cardiovascular adverse events.
BACKGROUND Patients with heart failure ( HF ) have abnormal endothelial function . Although use of a continuous flow left ventricular assist device ( CF-LVAD ) results in significant hemodynamic improvement , the effects on systemic endothelial function are unclear . METHODS AND RESULTS Eighteen HF patients with CF-LVAD implantation were included in this prospect i ve observational study . We measured  reactive hyperemia index ( RHI ) before and after CF-LVAD implantation to evaluate sequential changes in endothelial function . Patients were followed clinical ly for the occurrence of adverse cardiovascular events , a composite of death , thrombosis , bleeding , HF , renal failure , and arrhythmia . Preoperative RHI was 1.77±0.39 . Early in the postoperative period ( 7 - 14 days after operation ) RHI significantly decreased to 1.19±0.31 ( P<0.001 , compared with preoperative RHI ) . At first and second follow-up ( 4 - 6 weeks and 3 - 7 months after operation ) RHI remained lower at 1.48±0.50 ( P=0.030 ) and 1.26±0.37 ( P=0.002 ) , respectively , compared with preoperative RHI . The decrease in early postoperative RHI relative to preoperative RHI was significantly associated with adverse cardiovascular events  after CF-LVAD ( age-adjusted risk ratio for 0.25 decrease in RHI , 1.35 ; 95 % confidence interval : 1.13 - 1.62 , P=0.001 ) . CONCLUSIONS Peripheral endothelial function had a significant and persistent decline up to 5 months following implantation of CF-LVAD , and this decline was associated with adverse cardiovascular events . These findings may provide insight into some of the vascular complications following CF-LVAD in HF patients
In conclusion , statins were effective in preventing postoperative adhesion , as assessed based on gross and microscopic adhesion scores in rats
Adhesion is a significant concern after surgery .
Many research ers studied the anti-adhesive effect of statin , of which results were inconsistent .
Thus , we purpose d to perform a systematic review and meta- analysis to evaluate the effect of statins on postoperative adhesion in an experimental study .