Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .
Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment
Objective : To determine the efficacy of testosterone ( T ) supplementation on cognition in a sample of men with Alzheimer disease ( AD ) or mild cognitive impairment ( MCI ) . Methods : Fifteen patients with AD and 17 patients with MCI aged 63 to 85 years completed a r and omized , double-blind , placebo-controlled study . Nineteen participants received weekly intramuscular ( IM ) injections of 100 mg T enanthate and 13 participants received weekly injections of placebo ( saline ) for 6 weeks . Cognitive evaluations using a battery of neuropsychological tests were conducted at baseline , week 3 , and week 6 of treatment and again after 6 weeks of washout . Results : Peak serum total T levels were raised from baseline an average of 295 % in the active treatment group . Improvements in spatial memory ( p < 0.05 ) and constructional abilities ( p < 0.05 ) and verbal memory were evident in the T group . No changes were noted for selective and divided attention or language . Prostate specific antigen did not significantly change during this brief treatment . Conclusion : Testosterone supplementation may benefit selective cognitive functions in men with Alzheimer disease and mild cognitive impairment
Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .