Both synthetic and naturally derived crosslinkers have been found to exhibit significant effects in biomodification of dentine via their multiple interactions with the dentine matrix .
A stable matrix network or a durable hybrid layer in dentine bonding could be achieved , where the dentine collagen fibrils show improved biochemical and biomechanical properties and enzymatic biodegradation is reduced .
This aim of this review is to explore the current research related to  crosslinking agents used on dentine .
Dentin bond strengths as a function of solvent and glutaraldehyde content.
PURPOSE To evaluate the effect of the inclusion of glutaraldehyde on the shear bond strength of new ethanol-based adhesives ( Gluma Comfort Bond & Desensitizer , GCBD and Gluma Comfort Bond , GCB ) versus acetone-based Gluma One Bond ( GOB ) and a conventional three-step adhesive as a control . MATERIAL S AND METHODS Forty bovine incisors were mounted in acrylic ,  polished  to 600-grit , and r and omly assigned to four groups ( n=10 ) . Dentin was etched for 15 s using 35 % phosphoric acid , rinsed , and lightly dried . After adhesive application and curing , Charisma composite was applied in a # 5 gelatin capsule and light-cured . Specimens were loaded in shear using an Instron at 5 mm/min . Shear bond strengths were calculated by dividing failure load by bonded surface area . ANOVA showed a significant difference in means at P < 0.01 , so Tukey 's test was used for pairwise comparisons . RESULTS Mean SBS ( + /- SD , MPa ) were : GOB : 8 (4.4)ab ; GCB : 10 (4.4)ab ; GCBD : 14 (6)bc ; SBMP : 17.7 (6.4)c . Superscript letters indicate Tukey 's homogeneous subsets ( P < 0.05 )
Both synthetic and naturally derived crosslinkers have been found to exhibit significant effects in biomodification of dentine via their multiple interactions with the dentine matrix .
A stable matrix network or a durable hybrid layer in dentine bonding could be achieved , where the dentine collagen fibrils show improved biochemical and biomechanical properties and enzymatic biodegradation is reduced .
This aim of this review is to explore the current research related to  crosslinking agents used on dentine .