In several small , single-site RCTs , valproate and sulthiame were better than placebo for the management of recurrent aggression .
Conclusions : Currently available RCTs do not support the efficacy of anticonvulsants as mood stabilizers in children .
There is some preliminary evidence from small RCTs of the efficacy of some anticonvulsants in the control of aggression and behavioral dyscontrol in conduct disorder , autism , and intellectual disability
Aim : Anticonvulsant medications are frequently used in clinical practice to treat psychiatric disorders in children and adolescents , but the evidence for their efficacy is uncertain .
We conducted a systematic review of published r and omized controlled trials ( RCT ) that assessed the psychiatric benefit of anticonvulsants  in patients under 18 years of age .
A double blind randomized placebo control trial of levetiracetam in Tourette syndrome.
The objective of this study was to investigate the effectiveness of levetiracetam for the treatment of  tics in children with Tourette syndrome ( TS ) .  Levetiracetam , an atypical anticonvulsant , has been suggested in open-label protocol s to be an effective tic-suppressing agent in individuals with TS . A double blind , r and omized , placebo-controlled , cross-over trial was performed to investigate this medication in children with moderate to moderately-severe tics . Subjects received , in a r and omized sequence , 4-weeks of levetiracetam ( maximum dose 30 mg/kg/day ) or placebo , with a 2-week intervening washout period between cycles . Primary outcome measures included two separate scales from the Yale Global Tic Severity Scale ; the Total Tic score and the Total overall score . Measures were assessed at baseline , prior to r and omization , on Day 28 ( end of Phase 1 ) , on Day 42 ( baseline for second phase ) and on Day 70 ( end of Phase 2 ) . Twenty-two subjects ( 21 boys and 1 girl ) with TS , mean age 12.2 + /- 2.3 years , range 8 to 16 years , participated . A mild reduction in tics occurred during both the levetiracetam and placebo treatment phases . There was no significant difference between treatments and no evidence of sequence or cross-over effects . In conclusion , Levetiracetam is not more beneficial than placebo in suppressing tics in children with TS
In several small , single-site RCTs , valproate and sulthiame were better than placebo for the management of recurrent aggression .
Conclusions : Currently available RCTs do not support the efficacy of anticonvulsants as mood stabilizers in children .
There is some preliminary evidence from small RCTs of the efficacy of some anticonvulsants in the control of aggression and behavioral dyscontrol in conduct disorder , autism , and intellectual disability
Aim : Anticonvulsant medications are frequently used in clinical practice to treat psychiatric disorders in children and adolescents , but the evidence for their efficacy is uncertain .
We conducted a systematic review of published r and omized controlled trials ( RCT ) that assessed the psychiatric benefit of anticonvulsants  in patients under 18 years of age .