The 6MWD is usually negatively associated with a higher Body Mass Index , increased cigarette consumption , higher doses of antipsychotic medication and lower physical self-worth in individuals with schizophrenia .
The 6MWT demonstrates high reliability .
IMPLICATION S FOR REHABILITATION The Six-Minute Walk Test reliably assesses the functional exercise capacity in patients with schizophrenia .
The impact of therapeutic interventions on patients , as measured by the 6MWT , can not be confirmed .
PURPOSE The six-minute walk test ( 6MWT ) is a sub-maximal exercise test measuring the distance that a patient can walk quickly in a period of 6 minutes ( 6MWD ) .
The objectives of this systematic review are to evaluate the 6MWT 's suitability for measuring the impact of an intervention , to compare the 6MWD walked by patients with schizophrenia with data for the general population or matched controls , to identify the determinants of 6MWD and to examine the measurement properties and quality procedures of the 6MWT .
Interventions to reduce weight gain in schizophrenia.
Background Weight gain is common for people with schizophrenia and this has serious implication s for health and well being . Objectives To determine the effects of both pharmacological ( excluding medication switching ) and non pharmacological strategies for reducing or preventing weight gain in people with schizophrenia . Search methods We search ed key data bases and the Cochrane Schizophrenia Group 's trials register ( April 2006 ) , reference sections within relevant papers , h and search ed key journals , and contacted the first author of each relevant study and other experts to collect further information . Selection criteria We included all clinical r and omised controlled trials comparing any pharmacological or non pharmacological intervention for weight gain  ( diet and exercise counselling ) with st and ard care or other treatments for people with schizophrenia or schizophrenia-like illnesses . Data collection and analysis We reliably selected , quality assessed and extracted data from studies . As weight is a continuous outcome measurement , weighted mean differences ( WMD ) of the change from baseline were calculated . The primary outcome measure was weight loss . Main results Twenty-three r and omised controlled trials met the inclusion criteria for this review . Five trials assessed a cognitive/behavioural intervention and eighteen assessed a pharmacological adjunct . In terms of prevention , two cognitive/behavioural trials showed significant treatment effect ( mean weight change ) at end of treatment ( n=104 , 2 RCTs , WMD -3.38 kg CI -4.2 to -2.0 ) . Pharmacological adjunct treatments were significant with a modest prevention of weight gain ( n=274 , 6 RCTs , WMD - 1.16 kg CI -1.9 to -0.4 ) . In terms of treatments for weight loss , we found significantly greater weight reduction in the cognitive behavioural intervention group ( n=129 , 3 RCTs , WMD -1.69 kg CI -2.8 to -0.6 ) compared with st and ard care . Authors ' conclusions Modest weight loss can be achieved with selective pharmacological and non pharmacological interventions . However , interpretation is limited by the small number of studies , small sample size , short study duration and by variability of the interventions themselves , their intensity and duration . Future studies adequately powered , with longer treatment duration and rigorous methodology will be needed in further evaluating the efficacy and safety of weight loss interventions for moderating weight gain . At this stage , there is insufficient evidence to support the general use of pharmacological interventions for weight management in people with schizophrenia
The 6MWD is usually negatively associated with a higher Body Mass Index , increased cigarette consumption , higher doses of antipsychotic medication and lower physical self-worth in individuals with schizophrenia .
The 6MWT demonstrates high reliability .
IMPLICATION S FOR REHABILITATION The Six-Minute Walk Test reliably assesses the functional exercise capacity in patients with schizophrenia .
The impact of therapeutic interventions on patients , as measured by the 6MWT , can not be confirmed .
PURPOSE The six-minute walk test ( 6MWT ) is a sub-maximal exercise test measuring the distance that a patient can walk quickly in a period of 6 minutes ( 6MWD ) .
The objectives of this systematic review are to evaluate the 6MWT 's suitability for measuring the impact of an intervention , to compare the 6MWD walked by patients with schizophrenia with data for the general population or matched controls , to identify the determinants of 6MWD and to examine the measurement properties and quality procedures of the 6MWT .