There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .
Intravenous iron exacerbates oxidative DNA damage in peripheral blood lymphocytes in chronic hemodialysis patients.
Patients undergoing maintenance hemodialysis have elevated markers of oxidative stress , but the reasons for this are not fully understood . Intravenous administration of iron , which many of these patients receive , may provoke the generation of bioactive iron , which enhances oxidative stress and lipid peroxidation . In this study , 110 hemodialysis patients were r and omly assigned to five groups that were administered single intravenous doses of iron sucrose , ranging from 20 to 500 mg . A time- and dosage-dependent rise in lymphocyte 8-hydroxy-2'-deoxyguanosine ( 8-OHdG ) levels in lymphocyte DNA , a marker of oxidative DNA damage , with a significant increase at 2 h after intravenous iron of > or = 200 mg ( P < 0.05 ) . Four weeks later , patients were r and omly assigned to weekly iron sucrose ( 100 mg of elemental iron ) or saline for 12 wk , and 89 patients completed the study . Mean lymphocyte 8-OHdG content was significantly higher in patients receiving intravenous iron compared with control subjects ( P < 0.05 ) , especially in those with ferritin levels > 500 microg/L. In addition , flow cytometric techniques revealed increased production of reactive oxygen species in lymphocytes among those treated with intravenous iron . Treatment with intravenous iron but not saline was also associated with decreased plasma ascorbate and alpha-tocopherol levels and increased oxidized glutathione/reduced glutathione ratio ( P < 0.05 ) . In summary , intravenous iron sucrose provokes oxidative damage to peripheral blood lymphocyte DNA in hemodialysis patients , especially among those with high levels of ferritin
There was no increased risk of infections with IV iron .
Gastrointestinal AEs were reduced with IV iron .
CONCLUSION Intravenous iron therapy is not associated with an increased risk of SAEs or infections .
Infusion reactions are more pronounced with IV iron
OBJECTIVE To amass all available evidence regarding the safety of intravenous ( IV ) iron preparations to provide a true balance of efficacy and safety .