A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?
Fatigue in cancer patients treated with cytotoxic drugs
Study objectives . Cancer-related fatigue is a significant and distressing problem for the cancer patient , affecting their physical and psychosocial function negatively , and reducing their quality of life . The aims of this study were to assess frequency , severity , and the consequence of fatigue in cancer out patients receiving cytotoxic drugs  , using an existing international fatigue scale applied for Swedish use . Methods . The study used a non-r and omized , prospect i ve design to evaluate fatigue and its impact on quality of life in out patients receiving cytotoxic drugs .  Once a week , 147 cancer patients , in an outpatient ward for cytotoxic drug administration , filled out question naires containing 13 items from the Fatigue Symptom Inventory ( FSI ) , and five additional questions . Results . Prevalence of fatigue was 92 % in the week after all patients had received cytotoxic drugs , and patients were statistically significantly more fatigued during than before treatment . The degree of fatigue was highest the week after treatment , and declined over the following week . Other symptoms , especially depressed mood , showed a strong correlation with cancer and cytotoxic-induced fatigue . Lung and breast cancer patients experienced the highest degree of fatigue . Some cytotoxic drug regimens were , apart from the underlying disease , associated with high fatigue scores , eg , those with cyclophosphamide or gemcitabine . Patients not receiving first line treatment scored significantly higher fatigue with more influence on daily living . Conclusion . The study verified that fatigue is a common side effect , and affects quality of life negatively , even for out patients receiving cytotoxic drugs . The clinical oncology pharmacist must inform patients that a severe tiredness , fatigue , may follow cytotoxic drug administration
A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?