We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
The association of atopic dermatitis in infancy with immunoglobulin E food sensitization.
OBJECTIVE To prospect ively investigate the association of high levels of immunoglobulin E ( IgE ) sensitization to foods and the presence of atopic dermatitis ( judged by reported topical steroid use during the first 16 months of life ) in a birth cohort of 620 Australian children " at risk " of allergic disease because of family history . RESULTS A total of 559 of the children in the cohort were fully evaluated , and the cumulative prevalence of atopic dermatitis was 24 % . More children in the cohort who had atopic dermatitis had strongly positive skin test results ( > or = 4 + , histamine equivalent units , > or = approximately 6-mm wheal ) , consistent with IgE food sensitization to either cow 's milk , egg , or peanut at 6 months ( 22 % vs 5 % , chi(2 ) = 35 ; P < 10(-6 ) ) and at 12 months ( 36 % vs 11 % , chi(2 ) = 41 ; P < 10(-6 ) ) than those without atopic dermatitis . The calculated attributable risk percent for IgE food sensitization as a cause of atopic dermatitis was 65 % and 64 % at these times . In a separate group of infants with severe atopic dermatitis , the equivalent rates of IgE food sensitization at 6 months was 83 % and at 12 months , 65 % . CONCLUSION IgE food sensitization is a major risk factor for the presence of atopic dermatitis in infancy
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .