We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .
Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure.
BACKGROUND Fish oils have been shown to reduce production of tumor necrosis factor-alpha ( TNF-alpha ) in healthy subjects . We sought to evaluate the effects of fish oils on pro-inflammatory cytokines and body weight in patients with advanced heart failure . METHODS Fourteen patients ( New York Heart Association [ NYHA ] Class III to IV heart failure ) were r and omized in a double-blinded trial to active therapy with 8 g of n-3 fatty acids ( Group A , n = 7 ) or placebo ( Group B , n = 7 ) for 18 weeks . TNF-alpha and interleukin-1 ( IL-1 ) production were measured by radioimmunoassay after endotoxin stimulation of peripheral blood mononuclear cells . RESULTS Placebo-treated patients had a 44 % increase in TNF-alpha ( from 1.28 to 1.84 pg/ml ; p = 0.07 ) but no significant change in IL-1 ( from 0.68 to 0.78 pg/ml ) production . n-3 fatty acids result ed in a 59 % reduction in TNF-alpha ( from 1.64 to 0.68 pg/ml ; p = 0.02 ) and 39 % decrease in IL-1 ( from 1.98 to 1.21 pg/ml ; p = 0.09 ) production . There was an inverse correlation between change in TNF-alpha production and change in percent body fat ( r = -0.6 ; p = 0.02 ) . CONCLUSIONS Fish oils decrease TNF-alpha production in heart failure and improve body weight .  Fish oil therapy may represent a novel therapeutic approach in late-stage heart failure characterized by cardiac cachexia
We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .