Based on a low quality of evidence , home-based supervised exercise may lead to less improvement in maximum and pain-free walking distance , and in more improvement in daily life walking capacity , compared with hospital-based supervised exercise .
Home-based supervised exercise may improve maximum and pain-free walking distance compared with " go home and walk advice " and result in little or no difference in health-related quality of life and functional walking capacity compared with hospital-based supervised exercise or " go home and walk advice " .
OBJECTIVE To evaluate the effects of home-based supervised exercise vs hospital-based supervised exercise , and the effects of home-based supervised exercise vs unsupervised " go home and walk advice " on daily life and corridor-walking capacity , health-related quality of life and patient-reported functional walking capacity in patients with intermittent claudication .
Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial.
BACKGROUND Supervised exercise training ( SET ) is recommended as initial treatment to improve walking capacity in peripheral arterial disease ( PAD ) patients with intermittent claudication . Various mechanisms by which SET yields beneficial effects are postulated , however data regarding its influence on angiogenesis are scarce . Thus , we design ed a prospect i ve r and omized controlled trial to study the impact of SET on markers of angiogenesis and endothelial function in PAD . METHODS Forty PAD patients were r and omized to SET on top of best medical treatment ( SET+BMT )  for 6 months versus  best medical treatment ( BMT ) only . Endothelial progenitor cells ( EPC ) were assessed by whole-blood flow cytometry ( co-expression of CD34 + CD133 + KDR+ ) and cell culture assays ( endothelial cell-colony forming units , circulating angiogenic cells , migration assay ) at baseline , 3 , 6 and 12-months after inclusion . Changes of plasma levels of asymmetric dimethylarginine ( ADMA ) , vascular endothelial growth factor ( VEGF ) , stromal cell-derived factor-1 ( SDF-1 ) and maximum walking distance were determined . RESULTS EPC - measured by flow cytometric and cell culture techniques - increased significantly upon training paralleled by a significant decrease of ADMA when compared to the BMT group ( p<0.05 ) . Six months after training cessation , the beneficial effect of  SET  on EPC diminished , but maximum walking distance was significantly improved compared to baseline and controls ( p<0.05 ) . No significant changes were observed for VEGF and SDF-1 plasma levels in time course . CONCLUSIONS SET increases circulating EPC counts and decreases ADMA levels reflecting enhanced angiogenesis and improved endothelial function , which might contribute to cardiovascular risk reduction
Based on a low quality of evidence , home-based supervised exercise may lead to less improvement in maximum and pain-free walking distance , and in more improvement in daily life walking capacity , compared with hospital-based supervised exercise .
Home-based supervised exercise may improve maximum and pain-free walking distance compared with " go home and walk advice " and result in little or no difference in health-related quality of life and functional walking capacity compared with hospital-based supervised exercise or " go home and walk advice " .
OBJECTIVE To evaluate the effects of home-based supervised exercise vs hospital-based supervised exercise , and the effects of home-based supervised exercise vs unsupervised " go home and walk advice " on daily life and corridor-walking capacity , health-related quality of life and patient-reported functional walking capacity in patients with intermittent claudication .