This meta- analysis shows that oral tibolone treatment significantly lowers circulating Lp(a ) levels in postmenopausal women .
INTRODUCTION Circulating lipoprotein ( a ) ( Lp(a ) ) is a recognized risk factor for cardiovascular disease ( CVD ) .
Tibolone , a synthetic steroid , may lower Lp(a ) levels ; however , evidence of the effects of tibolone on Lp(a ) still remain to be defined .
Therefore , we investigated the effects of tibolone treatment on circulating Lp(a ) levels in postmenopausal women .
The influence of 5-year therapy with tibolone on the lipid profile in postmenopausal women with mild hypercholesterolemia
Our objective was to investigate the effects of 5-year therapy with tibolone on the lipid profile in postmenopausal women with mild hypercholesterolemia ( total cholesterol , 241 ± 7 mg/dl ; LDL cholesterol , 153 ± 9 mg/dl ) . Eighty-two patients were divided into two groups . Group A ( 53 women ) received 2.5 mg of tibolone per day . Group B ( 29 women ) received no tibolone . Total , low- and high-density lipoprotein cholesterol and lipoprotein(a ) were found to be decreased in the tibolone group , by 17.7 % , 32 % , 15.5 % and 12 % , respectively ( p < 0.01 ) throughout the 5-year treatment , while triglycerides showed no significant change . The lipid profile in the control group remained at its initial values . Menopausal symptoms disappeared in the treatment group within the first 5 months , whereas they deteriorated in the control group during the first 2 years . Although a few unwanted side-effects on hormonedependent tissues were observed ( including vaginal spotting in 11.3 % and febrile hemorrhagic cystic mastopathy in 3.8 % ) long-term therapy with tibolone seemed to be well tolerated , and appeared to have a beneficial effect on the levels of serum lipids
This meta- analysis shows that oral tibolone treatment significantly lowers circulating Lp(a ) levels in postmenopausal women .
INTRODUCTION Circulating lipoprotein ( a ) ( Lp(a ) ) is a recognized risk factor for cardiovascular disease ( CVD ) .
Tibolone , a synthetic steroid , may lower Lp(a ) levels ; however , evidence of the effects of tibolone on Lp(a ) still remain to be defined .
Therefore , we investigated the effects of tibolone treatment on circulating Lp(a ) levels in postmenopausal women .