Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .
Mechanical evaluation of the resistance and elastance of post-burn scars after topical treatment with tretinoin
OBJECTIVE : After burn injuries , scarred skin lacks elasticity , especially in hypertrophic scars . Topical treatment with tretinoin can improve the appearance and quality of the skin ( i.e. , texture , distensibility , color , and hydration ) . The objective of this prospect i ve study was to examine the effects of treatment with 0.05 % tretinoin for one year on the biomechanical behavior and histological changes undergone by facial skin with post-burn scarring . Setting : Tertiary , Institutional . METHOD : Fifteen female patients who had suffered partial thickness burns with more than two years of evolution were selected .  Skin biopsies were obtained initially and after one year of treatment . The resistance and elastance of these skin biopsies were measured using a mechanical oscillation analysis system . The density of collagen fibers , elastic fibers , and versican were determined using immunohistochemical analysis . RESULTS : Tretinoin treatment significantly lowered skin resistance and elastance , which is a result that indicates higher distensibility of the skin . However , tretinoin treatment did not significantly affect the density of collagen fibers , elastic fibers , or versican . CONCLUSION : Topical tretinoin treatment alters the mechanical behavior of post-burn scarred skin by improving its distensibility and thus leads to improved quality of life for patients
Contractubex showed best results in the prevention of pathological scars .
BACKGROUND The treatment and prevention of  hypertrophic scars and keloids  represents a special challenge particularly in plastic surgery .
Given their simple , non-invasive and painless application , topical preparations are an attractive therapeutic option .
On the part of the patients , the efficacy in prevention of and therapy for hypertrophic scars and keloids of these topical preparations is regularly question ed .
The clarification of this issue is subject of this review .