Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .
Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate.
An investigator blind trial was performed comparing bismuth salicylate , erythromycin ethylsuccinate , and placebo in the treatment of Campylobacter pyloridis associated gastritis in patients without peptic ulceration . Fifty patients fulfilled the study criteria . There was a strong correlation between the presence of C pyloridis and histologically confirmed gastritis . Clearance of organisms led to improvement of the gastritis . C pyloridis was cleared from 15 patients ; of these , 13 had gastritis initially , which resolved in 12 . Conversely , gastritis resolved in only four of 32 patients not cleared of organisms ( p less than 0.0001 ) . There was significantly greater improvement in endoscopic appearances in the patients cleared of C pyloridis compared with those whose infection persisted ( p less than 0.001 ) . In the three treatment groups organisms were cleared from 14 of 18 patients receiving the locally active bismuth salicylate , only one of 15 patients receiving erythromycin ethylsuccinate , and none of 17 patients taking placebo . These findings suggest that the ideal antimicrobial for the successful eradication of C pyloridis associated gastritis should be locally active , stable at low pH , and should penetrate gastric mucus . The resolution of gastritis and improvement in endoscopic appearances associated with clearance of C pyloridis support the view that these organisms may play a part in this condition
Reports of strong associations in small observational studies without appropriate adjustment for potential confounding factors were not generally confirmed by larger and better- design ed studies .
The available evidence indicates that there is no strong association between H pylori and dyspepsia , but there is insufficient evidence to confirm or refute the existence of a modest association
BACKGROUND Previous studies have yielded conflicting results and substantial uncertainty about any independent association of Helicobacter pylori infection with dyspepsia , and about any benefits of antibiotic treatments for nonulcer or uninvestigated dyspepsia .
OBJECTIVES To perform a systematic review of the literature to determine whether chronic infection with H pylori is relevant to nonulcer or uninvestigated dyspepsia .