There were no overall effects from antioxidant vitamins , inositol or dietary minerals on psychiatric symptoms .
There is preliminary evidence that certain vitamin and mineral supplements may reduce psychiatric symptoms in some people with schizophrenia .
BACKGROUND When used as an adjunctive with antipsychotics , certain vitamins and minerals may be effective for improving symptomatic outcomes of schizophrenia , by restoring nutritional deficits , reducing oxidative stress , or modulating neurological pathways .
Efficacy of Zinc Sulfate as an Add-on Therapy to Risperidone Versus Risperidone Alone in Patients With Schizophrenia: A Double-Blind Randomized Placebo-Controlled Trial
Background : Zinc can modulate fast-excitatory transmission , facilitate the release of amino butyric acid and potentiate nicotinic acetylcholine receptors . There are also emerging evidence s discussing the implication of these neurotransmitters in pathophysiology of schizophrenia . Objectives : The purpose of this study was to evaluate the efficacy of Zn sulfate as an add-on therapy in the treatment of schizophrenia in a 6-week , double-blind and placebo-controlled trial . Patients and Methods : Eligible participants were 30 in patients with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition , Text Revision criteria . Patients were r and omly allocated into two equal groups ; one group of patients received risperidone 6 mg/day plus capsules of Zn sulfate ( each containing 50 mg elemental Zn ) three times a day and another group received risperidone 6 mg/day plus placebo . The Positive and Negative Syndrome Scale ( PANSS ) was applied to assess the psychotic symptoms and aggression risk at baseline , week 2 , 4 , and 6 of the study . Results : The results of this study showed that both protocol s significantly decreased the scores on all subscales of the PANSS and supplemental aggression risk subscale as well as PANSS total score over the study . However , this improvement was significantly higher in Zn sulfate receiving group compared to the placebo group . No major clinical side-effects were detected . Conclusions : It may be concluded that Zn is an effective adjuvant agent in the management of patients with schizophrenia
There were no overall effects from antioxidant vitamins , inositol or dietary minerals on psychiatric symptoms .
There is preliminary evidence that certain vitamin and mineral supplements may reduce psychiatric symptoms in some people with schizophrenia .
BACKGROUND When used as an adjunctive with antipsychotics , certain vitamins and minerals may be effective for improving symptomatic outcomes of schizophrenia , by restoring nutritional deficits , reducing oxidative stress , or modulating neurological pathways .