In conclusion , statins were effective in preventing postoperative adhesion , as assessed based on gross and microscopic adhesion scores in rats
Adhesion is a significant concern after surgery .
Many research ers studied the anti-adhesive effect of statin , of which results were inconsistent .
Thus , we purpose d to perform a systematic review and meta- analysis to evaluate the effect of statins on postoperative adhesion in an experimental study .
Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 expression of glomerular mesangial cells in hypercholesterolemic rabbits.
Tissue factor ( TF ) and plasminogen activator inhibitor-1 ( PAI-1 ) activity and /or expression are upregulated in hypercholesterolemia . Despite extensive research on anti-thrombotic effect of statins , little is known about their effects on TF and PAI-1 expression in glomerular mesangial cells under hypercholesterolemic condition . Male rabbits were fed on either normal or high-cholesterol diet for 8 weeks . Then cholesterol-fed rabbits were r and omly assigned to simvastatin or starch . At the end of 12 weeks , glomerular mesangial cells were collected . The concentrations of TF and PAI-1 mRNA were detected by RT-PCR . The plasma activities of TF and PAI-1 were determined with enzyme linked immunosorbent assay ( ELISA ) and chromogenic substrate method , respectively . The atherogenic diet caused a consistent increase in serum concentrations of total cholesterol ( TC ) and serum triglyceride ( TG ) ( p < 0.05 ) , increased TF and PAI-1 mRNA expression in glomerular mesangial cells and plasma activities as compared to the normal diet ( p < 0.01 ) . Four-week simvastatin treatment result ed in significant decrease of mesangial TF and PAI-1 mRNA ( p < 0.01 ) , and also of the plasma activities of TF ( p < 0.05 ) and PAI-1 ( p < 0.01 ) . These results suggest that simvastatin might protect kidney from the formation of microthrombus under hypercholesterolemic condition and might be a possible pathogenesis of obesity-related glomerulopathy
In conclusion , statins were effective in preventing postoperative adhesion , as assessed based on gross and microscopic adhesion scores in rats
Adhesion is a significant concern after surgery .
Many research ers studied the anti-adhesive effect of statin , of which results were inconsistent .
Thus , we purpose d to perform a systematic review and meta- analysis to evaluate the effect of statins on postoperative adhesion in an experimental study .