Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .
Characterization of verbal and spatial memory changes from moderate to supraphysiological increases in serum testosterone in healthy older men
BACKGROUND It has been suggested that cognitive changes in response to T supplementation may occur within an ideal range . The objective of this study was to compare the cognitive responses of older , eugonadal men in whom moderate or large increases in serum testosterone levels was induced by exogenous testosterone supplementation .  DESIGN R and omized , double-blind , placebo-controlled study with subsequent grouping of participants according to average increase in circulating T from baseline . SETTING Community dwelling participants . PARTICIPANTS Fifty-seven healthy , eugonadal , community dwelling male volunteers , mean age 67 years ( + /-11 years ) . INTERVENTIONS Participants were r and omized to receive weekly intramuscular ( i.m . ) injections of either 50 , 100 or 300 mg T enanthate or placebo ( saline ) injection for 6 weeks . Cognitive evaluations using a battery of neuropsychological tests were conducted at baseline , weeks 3 and 6 of treatment and after 6 weeks of wash-out . MAIN OUTCOME MEASURES Performance on cognitive tests of verbal and spatial memory . RESULTS Men with moderate increases in serum T and /or its metabolites demonstrated significant improvements in verbal and spatial memory . In contrast , men with large or low increases in circulating T levels , failed to demonstrate significant changes in memory . CONCLUSION These results suggest that in healthy older men , beneficial changes in cognitive function induced by T supplementation are most evident with moderate changes in cognition from moderate to high T supplementation increases in T levels . Large or no to low increases in T levels do not appear to appreciably effect cognition
Testosterone supplementation did not show consistent benefit for cardiovascular risk , sexual function , mood and behavior , or cognition .
Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo .
Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido .
Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function .
Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality , psychological well-being , or mood .
Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of " low testosterone " ( low-T ) for cardiovascular health , sexual function , muscle weakness or wasting , mood and behavior , and cognition .