Overall , the current meta- analysis demonstrated that resveratrol intake significantly reduced weight , BMI , WC and fat mass , and significantly increased lean mass , but did not affect leptin and adiponectin levels
Abstract This systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to summarize the effect of resveratrol intake on weight loss .
Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study
Melinjo ( Gnetum gnemon L. ) seed extract ( MSE ) containing trans-resveratrol ( 3,5,4′-trihydroxy-trans-stilbene ) and other derivatives exerts various beneficial effects . However , its mechanism of action in humans remains unknown . In this study , we aim ed to investigate beneficial effects of MSE in healthy adult males . In this double-blind , r and omized controlled study , 30 males aged 35–70 years with ≤10 % flow-mediated dilatation received placebo or 750 mg MSE powder for 8 weeks , and twenty-nine males ( 45.1 ± 8.8 years old ) completed the trial . There was a significant difference in the melinjo and placebo groups . Compared with the placebo control , MSE significantly reduced serum uric acid at 4 weeks and 8 weeks ( n = 14 and 15 , resp . ) . HDL cholesterol was significantly increased in the melinjo group . To clarify the mechanism of MSE for reducing uric acid , we investigated xanthine oxidase inhibitory activity , angiotensin II type 1 ( AT1 ) receptor binding inhibition rate , and agonistic activities for PPARα and PPARγ  . MSE , trans-resveratrol , and a resveratrol dimer , gnetin C ( GC ) , significantly inhibit AT1 receptor binding and exhibit mild agonistic activities for PPARα and PPARγ . In conclusion , MSE may decrease serum uric acid regardless of insulin resistance and may improve lipid metabolism by increasing HDL cholesterol
Overall , the current meta- analysis demonstrated that resveratrol intake significantly reduced weight , BMI , WC and fat mass , and significantly increased lean mass , but did not affect leptin and adiponectin levels
Abstract This systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to summarize the effect of resveratrol intake on weight loss .