Despite the high risk of bias of many of the included studies , the results suggested that urinary iodine , thyroglobin , serum thyroxine , and thyroid-stimulating hormone are useful biomarkers of iodine status , at least in some groups .
BACKGROUND Biomarkers of iodine status are required to study iodine deficiency disorders in different parts of the world and to evaluate the effects of fortification strategies .
OBJECTIVE The objective was to assess the usefulness of biomarkers of iodine status in humans by systematic ally review ing intervention studies that altered iodine status .
Randomised trial of iodine intake and thyroid status in preterm infants
BACKGROUND Low levels of circulating thyroid hormones have been associated with poorer general and neurodevelopmental outcome in preterm babies and it has been speculated that the association is causal . Low levels of circulating thyroid hormone have been reported after inadequate intake of iodine in preterm infants being fed milk formula . AIM To investigate whether increased iodine intake from supplemented preterm formula would improve thyroid hormone levels in preterm babies ( this study ) and hence improve neurodevelopmental status ( planned subsequent study ) . METHOD A total of 121 preterm infants were entered into a r and omised controlled trial of st and ard ( 68 μg/l ) versus increased ( 272 μg/l ) iodine in preterm formula . RESULTS The two groups were comparable at recruitment . No evidence of an effect of the intervention on thyroid hormone levels was seen up to 41 weeks after conception . CONCLUSION Calls for increased iodine content of preterm infant formulas are not justified by this study . Key message Increasing milk iodine content in line with the latest recommendations for preterm babies had no effect on thyroid hormone levels in the perinatal
Despite the high risk of bias of many of the included studies , the results suggested that urinary iodine , thyroglobin , serum thyroxine , and thyroid-stimulating hormone are useful biomarkers of iodine status , at least in some groups .
BACKGROUND Biomarkers of iodine status are required to study iodine deficiency disorders in different parts of the world and to evaluate the effects of fortification strategies .
OBJECTIVE The objective was to assess the usefulness of biomarkers of iodine status in humans by systematic ally review ing intervention studies that altered iodine status .