These results provide evidence that olive oil might exert beneficial effects on endothelial function as well as markers of inflammation and endothelial function , thus representing a key ingredient contributing to the cardiovascular-protective effects of a Mediterranean diet .
The aim of the present systematic review was to synthesize data from r and omized controlled trials investigating the effects of olive oil on markers of inflammation or endothelial function .
Soluble adhesion molecules in healthy subjects: a dose-response study using n-3 fatty acids.
BACKGROUND AND AIM Long-chain n-3 polyunsaturated fatty acids ( PUFA ) may protect against atherosclerotic disease , and serum levels of soluble cellular adhesion molecules ( sCAMs ) possibly reflect the inflammatory process underlying atherosclerosis . We studied the effect of n-3 PUFA dietary supplementation on the serum levels of sP-selectin , soluble intercellular adhesion molecule-1 ( sICAM-1 ) and soluble vascular adhesion molecule-1 ( sVCAM-1 ) , and the correlation between sCAMs and the fatty acid composition of granulocyte membranes . METHODS AND RESULTS Sixty healthy volunteers were r and omly assigned to receive a daily supplement of n-3 PUFA 6.6 g , n-3 PUFA 2.0 g , or olive oil for 12 weeks in a double blind design . A significant negative correlation was found between serum sICAM-1 levels and the DHA content of granulocyte membranes at entry . After supplementation with 6.6 g of n-3 PUFA , there was a significant decrease only in sP-selectin , which a gender sub analysis showed to be more marked in men . Among the women , there was a significant decrease in sICAM-1 in the PUFA 2.0 g group and a significant increase in sVCAM-1 in the PUFA 6.6 g group . CONCLUSIONS The results indicate that high-dose supplementation with n-3 PUFA decreases sP-selectin levels in healthy subjects , thus suggesting a decrease in platelet reactivity or endothelial activation . However , the effect of n-3 PUFA on sCAMs is complex and may depend on gender and n-3 PUFA dose
These results provide evidence that olive oil might exert beneficial effects on endothelial function as well as markers of inflammation and endothelial function , thus representing a key ingredient contributing to the cardiovascular-protective effects of a Mediterranean diet .
The aim of the present systematic review was to synthesize data from r and omized controlled trials investigating the effects of olive oil on markers of inflammation or endothelial function .