This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .
The insulin sensitivity response is determined by the interaction between the G972R polymorphism of the insulin receptor substrate 1 gene and dietary fat.
SCOPE Insulin resistance , a condition associated with type 2 diabetes mellitus , results from the interaction of environmental and genetic factors . The aim of this study was to explore the influence of the G972R polymorphism at the insulin receptor substrate 1 gene on insulin sensitivity in a healthy young population . Furthermore , we examined whether the presence of this single nucleotide polymorphism ( SNP ; GR or GG ) interacts with dietary fat to modulate insulin sensitivity . METHODS AND RESULTS Fifty-nine healthy volunteers consumed three diets during 4 wk each following a r and omized crossover design : a saturated fatty acid diet , a low-fat and high carbohydrate ( CHO ) diet or a MUFA diet . For each diet , we investigated peripheral insulin sensitivity with the insulin suppression test . Steady-state plasma glucose and plasma-free fatty acids concentrations were significantly lower in GR subjects after the intake of a CHO diet , than did homozygous GG subjects ( p<0.05 ) . However , no differences were observed after consuming the two other diets . CONCLUSIONS Insulin sensitivity increased in GR subjects for the G972R polymorphism at the insulin receptor substrate 1 gene locus , after intake of a CHO diet . Increased knowledge of how these and other genes influence insulin sensitivity should increase the underst and ing of personalized nutrition
This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .