We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .
Early allergic sensitizations and their relevance to atopic diseases in children aged 6 years: results of the GINI study.
BACKGROUND Only a few studies have analyzed the value of early sensitization in predicting the development of atopic disease . The relevance of low immunoglobulin ( Ig ) E antibody levels in this respect also remains unclear . OBJECTIVE To investigate the relevance of sensitization in 12-month-old children in the development of atopic disease by the age of 6 years . METHODS We analyzed data for 1290 children with a positive family history of atopy from the prospect i ve , multicenter German Infant Nutritional Intervention ( GINIplus ) study and investigated the relationship between the presence of detectable specific IgE antibodies  at the age of 12 months and the development of atopic disease by the age of 6 years . RESULTS In all , 10.9 % of children analyzed developed sensitization . At the age of 6 years , 20.6 % of children with early sensitization had eczema compared to 9.4 % of those without ( odds ratio [ OR ] , 2.31 ; 95 % confidence interval [ CI ] , 1.42 - 3.74 ) . The corresponding figures were 15.4 % vs 7.3 % for allergic rhinitis ( OR , 2.22 ; CI , 1.31 - 3.78 ) and 10.2 % vs 2.6 % ( OR , 3.93 ; 95 % CI , 1.98 - 7.76 ) for asthma . Children with early sensitization to aeroallergens had the greatest risk of subsequent atopic disease . Early sensitization did not increase risk in children without eczema within the first year of life . Very low specific IgE levels ( 0.18 - 0.34 kU/L ) were not significantly associated with any of the outcomes analyzed . CONCLUSION Sensitization to common food allergens and to aeroallergens in particular during the first year of life was found to be a strong predictor for the development of atopic disease by the age of 6 years in children with a positive family history of atopy
We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease .
Very low- quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA .
Further trials are recommended before implementation of this practice .We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed
BACKGROUND Infant formulas containing hydrolysed proteins have been widely advocated for preventing allergic disease in infants , in place of st and ard cow 's milk formula ( CMF ) .
However , it is unclear whether the clinical trial evidence supports this .
OBJECTIVES To compare effects on allergic disease when infants are fed a hydrolysed formula versus CMF or human breast milk .
If hydrolysed formulas are effective , to determine what type of hydrolysed formula is most effective , including extensively or partially hydrolysed formula ( EHF/PHF ) .
To determine whether infants at low or high risk of allergic disease , and whether infants receiving early short-term ( first few days after birth ) or prolonged formula feeding benefit from hydrolysed formulas .