Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .
Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans.
BACKGROUND Animal studies have suggested that conjugated linoleic acid ( CLA ) , a natural component of ruminant meat and dairy products , may confer beneficial effects on health . However , little information on the effects of CLA on immune function is available , especially in humans . Furthermore , the effects of individual isomers of CLA have not been adequately investigated . OBJECTIVE This study investigated the effects of supplementing the diet with 3 doses of highly enriched cis-9,trans-11 CLA ( 0.59 , 1.19 , and 2.38 g/d ) or trans-10,cis-12 CLA ( 0.63 , 1.26 , and 2.52 g/d ) on immune outcomes in healthy humans . DESIGN The study had a r and omized , double-blind , crossover design . Healthy men consumed 1 , 2 , and 4 capsules sequentially that contained 80 % of either cis-9,trans-11 CLA or trans-10,cis-12 CLA for consecutive 8-wk periods . This regimen was followed by a 6-wk washout and a crossover to the other isomer . RESULTS Both CLA isomers decreased mitogen-induced T lymphocyte activation in a dose-dependent manner . There was a significant negative correlation between mitogen-induced T lymphocyte activation and the proportions of both cis-9,trans-11 CLA and trans-10,cis-12 CLA in peripheral blood mononuclear cell lipids . However , CLA did not affect lymphocyte sub population s or serum concentrations of C-reactive protein and did not have any consistent effects on ex vivo cytokine production . CONCLUSION CLA supplementation results in a dose-dependent reduction in the mitogen-induced activation of T lymphocytes . The effects of cis-9,trans-11 CLA and trans-10,cis-12 CLA were similar , and there was a negative correlation between mitogen-induced T lymphocyte activation and the cis-9,trans-11 CLA and trans-10,cis-12 CLA contents of mononuclear cells
Conclusion The current systematic review and meta- analysis showed that the long-term consumption of CLA increases the levels of CRP and Lp(a )
Background C-reactive protein ( CRP ) and lipoprotein ( a ) ( Lp[a ] ) play essential roles in cardiovascular disease incidence .
This study aim ed to review the association between the intake of conjugated linoleic acid ( CLA ) in the form of dietary supplement or enriched food with different treatment duration s and the levels of Lp(a ) and CRP in human studies .