Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention .
The data are insufficient to recommend the use of statins before EC .
Finally , perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF
The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation ( AF ) , inflammation and oxidative stress , with emphasis on the potential of statins to decrease the incidence of different types of AF , including new-onset AF , after electrical cardioversion ( EC ) and after cardiac surgery .
Observational and clinical trials have studied the impact of statin therapy on new-onset , post-EC or postoperative AF .
Dyslipidemia and an Unfavorable Fatty Acid Profile Predict Left Ventricular Hypertrophy 20 Years Later
Background —Left ventricular hypertrophy ( LVH ) is a common risk factor for cardiovascular mortality . Causes other than hypertension have not previously been investigated longitudinally . The aim of the present study was to determine hemodynamic , metabolic , and psychosocial predictors at 50 years of age for the prevalence of echocardiographic LVH and geometric subtypes at age 70 by use of a large sample of men from the general population followed up for 20 years . Methods and Results —In 1970 to 1973 , all men born from 1920 to 1924 and residing in Uppsala County , Sweden , were invited to participate in a health survey aim ed at identifying risk factors for cardiovascular disease . At a reinvestigation 20 years later , echocardiographic left ventricular mass index was determined in 475 subjects . A 1-SD increase in body mass index , systolic or diastolic blood pressure , fasting LDL/HDL cholesterol , serum triglycerides , or the serum cholesterol ester proportion of several saturated fatty acids or oleic acid at age 50 significantly increased the odds of having LVH at age 70 by 27 % to 41 % , whereas an increase in linoleic acid proportion was protective . Almost all metabolic predictors were independent of ischemic heart disease , valvular disease , and use of antihypertensive medication at age 70 . Conclusions —Dyslipidemia and indices of a low dietary intake of linoleic acid and high intake of saturated and monounsaturated fats , as well as hypertension and obesity , at age 50 predicted the prevalence of LVH 20 years later in this prospect i ve longitudinal cohort study , thereby suggesting that lipids may be important in the origin of LVH
Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention .
The data are insufficient to recommend the use of statins before EC .
Finally , perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF
The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation ( AF ) , inflammation and oxidative stress , with emphasis on the potential of statins to decrease the incidence of different types of AF , including new-onset AF , after electrical cardioversion ( EC ) and after cardiac surgery .
Observational and clinical trials have studied the impact of statin therapy on new-onset , post-EC or postoperative AF .