D and PA+D  interventions had larger effects on glucose reduction  than PA alone .
Lifestyle  interventions significantly improved FPG , HbA1c , FI , HOMA-IR , and bodyweight among adults without IGT or diabetes , and might reduce progression of hyperglycemia to type 2 diabetes mellitus
This study systematic ally assessed the effectiveness of lifestyle interventions on glycemic indicators among adults ( ⩾18years ) without IGT or diabetes .
Effects of TCF7L2 polymorphisms on glucose values after a lifestyle intervention.
BACKGROUND TCF7L2 is the strongest locus linked to type 2 diabetes that has been identified thus far , and rs7903146 is the most significantly associated variant . Few intervention studies have shown that it has negative effects on metabolic improvement after lifestyle programs . OBJECTIVE Our objective was to assess the effects of this variant on lifestyle intervention-induced  changes in glucose values and metabolic variables at 1- and 4-y follow-ups . DESIGN The rs7903146 variant was genotyped in 335 nondiabetic , dysmetabolic participants in a r and omized lifestyle intervention trial . RESULTS Subjects with the unfavorable TT genotype showed higher values of fasting glucose and lower homeostasis model assessment of beta cell function at baseline . Lifestyle modifications were successful in the amelioration of metabolic traits in all genetic subgroups after 1 y. At 4-y follow-up most of the metabolic benefits had disappeared . In a multiple regression model , values for glucose and homeostasis model assessment of beta cell function at 4 y were significantly associated with the T allele ( for glucose and homeostasis model assessment s , respectively : beta = 6.6 ; 95 % CI : 2.5 , 10.7 ; P = 0.001 ; and beta = -0.37 ; 95 % CI : -0.54 , -0.20 ; P < 0.001 ) but not with intervention . There was no interaction between genotype and intervention . After 1 y , impaired fasting glucose and diabetes incidence were inversely associated with intervention . After 4 y , the presence of a T allele was associated with impaired fasting glucose ( odds ratio : 3.04 ; 95 % CI : 1.53 , 6.04 ; P = 0.001 ) and diabetes ( odds ratio : 2.63 ; 95 % CI : 1.00 , 6.96 ; P = 0.05 ) but not with intervention . CONCLUSIONS Lifestyle modifications improved the metabolic pattern in all genetic subgroups . At the end of the trial , however , weight gain occurred , and carriers of the T allele developed first hyperglycemia and decreased insulin secretion , which suggests the need for different " after-care " preventive approaches tailored to each genotype 's metabolic risk
D and PA+D  interventions had larger effects on glucose reduction  than PA alone .
Lifestyle  interventions significantly improved FPG , HbA1c , FI , HOMA-IR , and bodyweight among adults without IGT or diabetes , and might reduce progression of hyperglycemia to type 2 diabetes mellitus
This study systematic ally assessed the effectiveness of lifestyle interventions on glycemic indicators among adults ( ⩾18years ) without IGT or diabetes .