Meta-regression showed that gastric pouch volume , alimentary limb length and biliopancreatic limb length were not associated with changes in ghrelin levels .
Conclusion Fasting total ghrelin levels decreased in the short term ( ≤ 3 months ) and increased in the long term ( > 3 months ) after RYGB
Background Roux-en-Y gastric bypass ( RYGB ) is considered effective for weight loss and for treatment of many obesity-related metabolic diseases .
Ghrelin is an essential orexigenic peptide that plays an indispensable role in controlling body weight and energy homeostasis of post-operative patients .
This systematic review and meta- analysis aim ed to investigate changes in the level of fasting total ghrelin following RYGB .
Early weight regain after gastric bypass does not affect insulin sensitivity but is associated with higher ghrelin levels
Objectives We sought to determine : 1 ) if early weight regain between one and two years after RYGB is associated with worsened hepatic and peripheral insulin sensitivity , and 2 ) if preoperative levels of ghrelin and leptin are associated with early weight regain after RYGB . Design and Methods Hepatic and peripheral insulin sensitivity and ghrelin and leptin plasma levels were assessed longitudinally in 45 subjects before RYGB  and at one month , six months , one year , and two years post operatively . Weight regain was defined as ≥ 5 % increase in body weight between one and two years after RYGB . Results Weight regain occurred in 33 % of subjects , with an average increase in body weight of 10 ± 5 % ( 8.5 ± 3.3 kg ) . Weight regain was not associated with worsening of peripheral or hepatic insulin sensitivity . Subjects with weight regain after RYGB had higher preoperative and postoperative levels of ghrelin compared to those who maintained or lost weight during this time . Conversely , the trajectories of leptin levels corresponded with the trajectories of fat mass in both groups . Conclusions Early weight regain after RYGB is not associated with a reversal of improvements in insulin sensitivity . Higher preoperative ghrelin levels might identify patients that are more susceptible to weight regain after RYGB
Meta-regression showed that gastric pouch volume , alimentary limb length and biliopancreatic limb length were not associated with changes in ghrelin levels .
Conclusion Fasting total ghrelin levels decreased in the short term ( ≤ 3 months ) and increased in the long term ( > 3 months ) after RYGB
Background Roux-en-Y gastric bypass ( RYGB ) is considered effective for weight loss and for treatment of many obesity-related metabolic diseases .
Ghrelin is an essential orexigenic peptide that plays an indispensable role in controlling body weight and energy homeostasis of post-operative patients .
This systematic review and meta- analysis aim ed to investigate changes in the level of fasting total ghrelin following RYGB .