INTERPRETATION The guidelines have improved method ological reporting in RSA studies , but adherence to these guidelines is still relatively low .
BACKGROUND AND PURPOSE Guidelines for st and ardization of  radiostereometry ( RSA )  of implants were published in 2005 to facilitate comparison of outcomes between various research groups .
In this systematic review , we determined how well studies have adhered to these guidelines .
Clodronate prevents prosthetic migration: A randomized radiostereometric study of 50 total knee patients
In a double-blind study , we r and omized 50 patients to receive peroral clodronate medication or placebo from 3 weeks before until 6 months after a total knee replacement with a cemented NexGen implant .  Migration of the tibial components was measured by radiostereometry at 1 year . Clodronate reduced prosthetic migration , as measured by maximum total point motion , from 0.40 mm to 0.29 mm ( p = 0.01 ) . This confirms that the early postoperative migration is related to bone resorption and thus the biology of the bone bed . Since early migration is related to late loosening , 6 months of clodronate medication might reduce the risk of loosening
INTERPRETATION The guidelines have improved method ological reporting in RSA studies , but adherence to these guidelines is still relatively low .
BACKGROUND AND PURPOSE Guidelines for st and ardization of  radiostereometry ( RSA )  of implants were published in 2005 to facilitate comparison of outcomes between various research groups .
In this systematic review , we determined how well studies have adhered to these guidelines .