Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .
Oats and soy in lipid-lowering diets for women with hypercholesterolemia: is there synergy?
OBJECTIVES To study possible synergistic effects of oats and soy on reducing total and low-density lipoprotein cholesterol ( LDL-C ) concentrations in human beings and the efficacy and feasibility of including these adjustments to a National Cholesterol Education Program Step I diet . SUBJECT/ SETTING : One hundred twenty-seven postmenopausal women with moderate hypercholesterolemia were recruited from a large Midwestern workforce and senior centers in the surrounding community . Intervention and clinical visits were conducted in these same facilities . DESIGN After a 3-week lead-in period on the Step I diet , participants were r and omly assigned to 1 of 4 dietary treatments for an additional 6 weeks : an oats/milk group , a wheat/soy group , an oats/soy group , and a wheat/milk group . Clinical measurements included blood draws , body weight and height , blood pressure , and medical history data . Three-day food records were collected at baseline and Weeks 3 and 9 of the intervention . R and omization was stratified based on the status of hormone replacement therapy and was blocked with sizes 4 or 8 for group assignment . RESULTS After 3 weeks on the Step I diet , total cholesterol , LDL-C , and triglyceride levels ; total fat and saturated fat intake , dietary cholesterol intake , Keys score , and body mass index were all reduced . Following an additional 6 weeks on the Step I diet plus intervention , total cholesterol and LDL-C were further reduced for both the oats/soy group and oats/milk group . There were no significant further changes in total cholesterol , LDL-C , or high-density lipoprotein cholesterol levels in the wheat/soy and wheat/milk groups . Body mass index remained stable in all groups from Week 3 to Week 9 . APPLICATIONS Nonpharmacologic dietary interventions like the Step I diet are feasible in a community setting and can produce rapid and significant lipid-lowering benefits . Daily consumption of 2 servings of oats can contribute to further lipid alterations in this population although soy intake at this dose may not . Palatability and convenience are important considerations in achieving dietary adherence
Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol , non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction
Oats are a rich source of β-glucan , a viscous , soluble fibre recognised for its cholesterol-lowering properties , and are associated with reduced risk of CVD .
Our objective was to conduct a systematic review and meta- analysis of r and omised-controlled trials ( RCT ) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol , non-HDL-cholesterol and apoB for the risk reduction of CVD .