Antiplatelet agents have a beneficial effect in reducing all cause mortality and fatal cardiovascular events in patients with IC .
BACKGROUND Peripheral arterial disease ( PAD ) is common and is a marker of systemic atherosclerosis .
Patients with symptoms of intermittent claudication ( IC ) are at increased risk of cardiovascular events ( myocardial infa rct ion ( MI ) and stroke ) and of both cardiovascular and all cause mortality .
OBJECTIVES To determine the effectiveness of antiplatelet agents in reducing mortality ( all cause and cardiovascular ) and cardiovascular events in patients with intermittent claudication .
Double-blind, controlled, multicenter study of indobufen versus placebo in patients with intermittent claudication.
The objective of the study was to evaluate the efficacy and safety of indobufen compared with placebo in the treatment of moderately severe intermittent claudication . The study consisted of a four-week single-blind , placebo-controlled run-in phase , followed by a six-month double-blind r and omized treatment period . A total of 302 patients were allocated to treatment with either placebo ( 154 patients ) or indobufen ( 148 ) 200 mg twice daily . The results of the overall intention-to-treat analysis of the study population showed statistically significant superiority of indobufen over placebo after six months for both the initial ( ICD ) and absolute claudication distances ( ACD ) . The ICD before treatment with indobufen or placebo averaged 137.9 + /- 68.2 and 136.6 + /- 63.2 m ( mean + /- SD ) , respectively . After six months ' treatment with active drug or placebo , this parameter reached 227.9 + /- 174.4 and 153.1 + /- 86.8 m ( mean + /- SD ) , respectively ( p < 0.01 ) . Similar results were obtained on ACD . The reduction of lower limb symptoms also suggested a greater clinical benefit in the indobufen-treated patients . There was no significant change in either group in the ankle/arm pressure ratio at the end of treatment . Adverse events of any type were reported by 18 patients ( 12.2 % ) in the indobufen group and by 11 patients ( 7.2 % ) in the placebo group . The mechanism whereby the drug is effective in this clinical condition could be related to both its antiplatelet and hemorheologic effects
Antiplatelet agents have a beneficial effect in reducing all cause mortality and fatal cardiovascular events in patients with IC .
BACKGROUND Peripheral arterial disease ( PAD ) is common and is a marker of systemic atherosclerosis .
Patients with symptoms of intermittent claudication ( IC ) are at increased risk of cardiovascular events ( myocardial infa rct ion ( MI ) and stroke ) and of both cardiovascular and all cause mortality .
OBJECTIVES To determine the effectiveness of antiplatelet agents in reducing mortality ( all cause and cardiovascular ) and cardiovascular events in patients with intermittent claudication .