Conclusions Large r and omized controlled trials of at least 6 months duration with carbohydrate restriction appear superior in improving lipid markers when compared with low-fat diets .
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk .
Objective A systematic review and meta-analyses were conducted to compare the effects of very low , low , and moderate carbohydrate , higher fat diets versus high-carbohydrate , low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults .
Effects of dietary saturated fat on LDL subclasses and apolipoprotein CIII in men
Background / objectives : Small dense low-density lipoprotein ( LDL ) particles and apolipoprotein ( apo ) CIII are risk factors for cardiovascular disease ( CVD ) that can be modulated by diet , but there is little information regarding the effects of dietary saturated fat on their plasma levels . We tested the effects of high vs low saturated fat intake in the context of a high beef protein diet on levels and composition of LDL subclasses and on apoCIII levels in plasma and LDL.Subjects/ methods : Following consumption of a baseline diet ( 50 % carbohydrate ( CHO ) , 13 % protein , 38 % total fat , 15 % saturated fat ) for 3 weeks , 14 healthy men were r and omly assigned to two reduced CHO high beef protein diets ( 31 % CHO , 31 % protein , 38 % fat ) that differed in saturated fat content ( 15 % vs 8 % ) for 3 weeks each in a crossover design . Results : The high saturated fat ( HSF ) diet result ed in higher mass concentrations of buoyant LDL I , medium density LDL II and dense LDL III , but not the very dense LDL IV ; and significant increases in plasma and LDL apoCIII concentration of 9.4 % and 33.5 % , respectively . The saturated fat-induced changes in LDL apoCIII were specifically correlated with changes in apoCIII content of LDL IV . Conclusions : Taken together with previous observations , these findings suggest that , at least in the context of a lower CHO high beef protein diet , HSF intake may increase CVD risk by metabolic processes that involve apoCIII
Conclusions Large r and omized controlled trials of at least 6 months duration with carbohydrate restriction appear superior in improving lipid markers when compared with low-fat diets .
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk .
Objective A systematic review and meta-analyses were conducted to compare the effects of very low , low , and moderate carbohydrate , higher fat diets versus high-carbohydrate , low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults .