RESULTS The instruments most frequently used were single-item VAS and Biberoglu and Behrman pain score , while multidimensional inventories were used in few studies .
The results of clinical studies in CPP are more frequently based on one-dimensional measurements .
RATIONALE Many types of  pain assessment are available to research ers carrying out clinical trials in chronic pelvic pain ( CPP ) , ranging from a single-item scale to multidimensional inventories .
AIM Our objective was to investigate which assessment s of pain are more commonly used in clinical trials on CPP .
Delayed Oral Estradiol Combined with Leuprolide Increases Endometriosis-Related Pain
Objectives : To determine if low-dose estrogen replacement can be added to GnRH agonist therapy after three months to reduce hypoestrogenic symptoms while allowing continued relief of pain in patients with endometriosis . Material s and Methods : Thirteen women with endometriosis and pain were treated with six months of leuprolide acetate in a prospect i ve , r and omized double-blind placebo controlled study . After three months of therapy , six subjects initiated oral estradiol 1 mg daily , and seven received an identical placebo . Results : Dysmenorrhea improved in both groups , and dyspareunia significantly improved in the GnRH agonist plus placebo group . The mean pain scores of the oral estrogen group tended to be higher than the placebo group , and hot flushes tended to be less severe with estrogen treatment . However , differences observed between the study and placebo groups did not reach statistical significance . Conclusion : In a prospect i ve , r and omized study , low-dose estrogen replacement increases endometriosis-related pain during GnRH agonist therapy . The study was terminated after the first 13 subjects due to the concerning trend toward recurrent symptoms in women who received oral estradiol during GnRH agonist therapy for endometriosis-related pain . With the trend toward increasing pain with estrogen add-back therapy , a larger study would not seem to be justifiable
RESULTS The instruments most frequently used were single-item VAS and Biberoglu and Behrman pain score , while multidimensional inventories were used in few studies .
The results of clinical studies in CPP are more frequently based on one-dimensional measurements .
RATIONALE Many types of  pain assessment are available to research ers carrying out clinical trials in chronic pelvic pain ( CPP ) , ranging from a single-item scale to multidimensional inventories .
AIM Our objective was to investigate which assessment s of pain are more commonly used in clinical trials on CPP .