However , resveratrol was not significantly effective on total cholesterol in both sample s. The results of subgroup analysis of human studies showed that resveratrol has significant effect on metabolic parameters ( glucose level and WC ) at the dosage of > 500 mg and with long-term interventions ≥ 10 weeks .
Administration of resveratrol can meaningfully reduce the BW , WC , TGs , and glucose level , also it can increase HDL , but not total cholesterol
This meta- analysis was carried out to determine the association between the resveratrol intake with metabolic parameters in metabolic syndrome patients .
The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men
Polyphenolic compounds , such as resveratrol , have recently received widespread interest because of their ability to mimic effects of calorie restriction . The objective of the present study was to gain more insight into the effects of 30 days resveratrol supplementation on adipose tissue morphology and underlying processes . Eleven healthy obese men were supplemented with placebo and resveratrol for 30 days ( 150 mg per day ) , separated by a 4-week washout period in a double-blind r and omized crossover design . A postpr and ial abdominal subcutaneous adipose tissue biopsy was collected to assess adipose tissue morphology and gene expression using microarray analysis . Resveratrol significantly decreased adipocyte size , with a shift toward a reduction in the proportion of large and very-large adipocytes and an increase in small adipocytes . Microarray analysis revealed downregulation of Wnt and Notch signaling pathways and upregulation of pathways involved in cell cycle regulation after resveratrol supplementation , suggesting enhanced adipogenesis . Furthermore , lysosomal/phagosomal pathway and transcription factor EB were upregulated reflecting an alternative pathway of lipid breakdown by autophagy . Further research is necessary to investigate whether resveratrol improves adipose tissue function
However , resveratrol was not significantly effective on total cholesterol in both sample s. The results of subgroup analysis of human studies showed that resveratrol has significant effect on metabolic parameters ( glucose level and WC ) at the dosage of > 500 mg and with long-term interventions ≥ 10 weeks .
Administration of resveratrol can meaningfully reduce the BW , WC , TGs , and glucose level , also it can increase HDL , but not total cholesterol
This meta- analysis was carried out to determine the association between the resveratrol intake with metabolic parameters in metabolic syndrome patients .