Neither latitude , region of the world , nor laboratory methodology were found to be associated with the prevalence of hypovitaminosis
BACKGROUND Hypovitaminosis D is considered a global public health issue .
Knowledge of its true dimensions will allow us to design interventions and plan preventive measures that can have a significant impact on human health .
OBJECTIVES The aim of this study was to evaluate the prevalence of hypovitaminosis D , defined as a serum 25-hydroxyvitamin D concentration < 30 ng/ml , in postmenopausal women around the world , as well as to identify the potential associated factors .
The levels of bone turnover markers in Chinese postmenopausal women: Peking Vertebral Fracture study
Objective : The aim of this study was to evaluate serum N-aminoterminal propeptide of type I collagen ( P1NP ) , C-terminal telopeptide of type I collagen ( & bgr;-CTX ) , and vitamin D status in healthy Chinese postmenopausal women . The study was also design ed to investigate their possible relationships with osteoporosis phenotypes . Methods : A community-based population of 1,724 postmenopausal women in Beijing was r and omly selected .  Serum bone turnover markers and 25-hydroxyvitamin D [ 25(OH)D ]  were tested by an automated Roche electrochemiluminescence system . Dual-energy x-ray absorptiometry was used to measure bone mineral density ( BMD ) . Results : The mean ( SD ) values of serum & bgr;-CTX and P1NP were 0.439 ( 0.210 ) and 56.7 ( 27.9 ) ng/mL , respectively . The 25(OH)D level of postmenopausal women in Beijing was remarkably low ( 13.2 ± 5.4 ng/mL ) . Serum & bgr;-CTX and P1NP levels were negatively correlated with BMDs of lumbar spine , femoral neck , and total hip ( all P < 0.01 ) . The cubic regression model better fitted the relationships of BMD and bone turnover markers . Serum & bgr;-CTX levels were significantly higher in women with sustained osteoporotic fracture or vertebral fracture ( P = 0.006 and 0.012 , respectively ) . No association between P1NP and fracture or vertebral fracture was detected . The same situation applied to 25(OH)D. 25(OH)D was negatively correlated with & bgr;-CTX and P1NP ( r = −0.073 and −0.088 , P = 0.002 and < 0.001 , respectively ) . Conclusions : Serum & bgr;-CTX and P1NP levels were negatively correlated with BMD . & bgr;-CTX was significantly higher in postmenopausal women with sustained fracture or vertebral fracture . Vitamin D deficiency was highly prevalent in postmenopausal women in Beijing
Neither latitude , region of the world , nor laboratory methodology were found to be associated with the prevalence of hypovitaminosis
BACKGROUND Hypovitaminosis D is considered a global public health issue .
Knowledge of its true dimensions will allow us to design interventions and plan preventive measures that can have a significant impact on human health .
OBJECTIVES The aim of this study was to evaluate the prevalence of hypovitaminosis D , defined as a serum 25-hydroxyvitamin D concentration < 30 ng/ml , in postmenopausal women around the world , as well as to identify the potential associated factors .