HRM  treatment is associated with clinical improvement in diseases of the skin , respiratory , circulatory , digestive and nervous system among others .
The scientific literature of the last decade has shown that a number of non-musculoskeletal disorders are treated with different kinds of  HRM .
Health resort medicine ( HRM ; in German : Kurortmedizin ) is a field of medicine with long-lasting tradition in several European countries .
A number of systematic review s have shown the effectiveness of HRM  in musculoskeletal conditions .
Review s focusing on the effectiveness of HRM in non-musculoskeletal disorders are rare .
This systematic review aims to provide an overview about all types of health resort treatments applied in non-musculoskeletal conditions , to summarize evidence for its effectiveness and to assess the quality of published studies .
Effects of a bicarbonate-alkaline mineral water on gastric functions and functional dyspepsia: a preclinical and clinical study.
The present study was performed in order to evaluate : ( 1 ) the influence of a bicarbonate-alkaline mineral water ( Uliveto ) on digestive symptoms in patients with functional dyspepsia ; ( 2 ) the effects of Uliveto on pre clinical models of gastric functions . Selected patients complained of dyspeptic symptoms in the absence of digestive lesions or Helicobacter pylori infection within the previous 3 months . They were treated with Uliveto water ( 1.5 l day(-1 ) ) for 30 days . Frequency and severity of symptoms were assessed at baseline and day 30 by a score system . Pre clinical experiments were carried out on rats , allowed to drink Uliveto or oligomineral water for 30 days . Animals then underwent pylorus ligation to evaluate gastric secretion of acid , pepsinogen , and mucus . In separate experiments , gastric emptying was assessed . Crenotherapy was associated with a relief of epigastric pain , retrosternal pyrosis , postpr and ial fullness and gastric distention . At pre clinical level , Uliveto water increased acid and pepsinogen secretions as well as gastric emptying , without changes in bound mucus . The enhancing actions of Uliveto on gastric secretions and emptying were prevented by L-365,260 , an antagonist of gastrin/CCK-2 receptors . These findings indicate that a regular intake of Uliveto favors an improvement of dyspeptic symptoms . The pre clinical study suggests that the clinical actions of Uliveto water depend mainly on its ability to enhance gastric motor and secretory functions
HRM  treatment is associated with clinical improvement in diseases of the skin , respiratory , circulatory , digestive and nervous system among others .
The scientific literature of the last decade has shown that a number of non-musculoskeletal disorders are treated with different kinds of  HRM .
Health resort medicine ( HRM ; in German : Kurortmedizin ) is a field of medicine with long-lasting tradition in several European countries .
A number of systematic review s have shown the effectiveness of HRM  in musculoskeletal conditions .
Review s focusing on the effectiveness of HRM in non-musculoskeletal disorders are rare .
This systematic review aims to provide an overview about all types of health resort treatments applied in non-musculoskeletal conditions , to summarize evidence for its effectiveness and to assess the quality of published studies .