All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .
Screening for predictors of adverse outcome in onco-geriatric surgical patients: A multicenter prospective cohort study.
AIMS The aim of this study was to investigate the predictive ability of screening tools regarding the occurrence of major postoperative complications in onco-geriatric surgical patients and to propose a scoring system . METHODS 328 patients ≥ 70 years undergoing surgery for solid tumors were prospect ively recruited . Preoperatively , twelve screening tools were administered . Primary endpoint was the incidence of major complications within 30 days . Odds ratios ( OR ) and 95 % confidence intervals ( 95 % CI ) were estimated using logistic regression . A scoring system was derived from multivariate logistic regression analysis . The area under the receiver operating characteristic curve ( AUC ) was applied to evaluate model performance . RESULTS At a median age of 76 years , 61 patients ( 18.6 % ) experienced major complications . In multivariate analysis , Timed Up and Go ( TUG ) , ASA-classification and Nutritional Risk Screening ( NRS ) were predictors of major complications ( TUG>20 OR 3.1 , 95 % CI 1.1 - 8.6 ; ASA ≥ 3 OR 2.8 , 95 % CI 1.2 - 6.3 ; NRS impaired OR 3.3 , 95 % CI 1.6 - 6.8 ) . The scoring system , including TUG , ASA , NRS , gender and type of surgery , showed good accuracy ( AUC : 0.81 , 95 % CI 0.75 - 0.86 ) . The negative predictive value with a cut-off point > 8 was 93.8 % and the positive predictive value was 40.3 % . CONCLUSIONS A substantial number of patients experience major postoperative complications . TUG , ASA and NRS are screening tools predictive of the occurrence of major postoperative complications and , together with gender and type of surgery , compose a good scoring system
All eight domains were predictive for at least one of the investigated outcomes but the results were quite variable across studies .
Physical function and nutritional status were the domains most often associated with mortality and systemic treatment-related outcomes , and the domain physical function was most often associated with postoperative complications .
Overall , this review demonstrates that the GA should minimally consist of physical function and nutritional status , when the aim is to predict patients -related outcomes of older patients with cancer , although the results are quite heterogeneous .
BACKGROUND A geriatric assessment ( GA ) is increasingly used to help guide treatment decisions in older patients with cancer .
However , there is no consensus regarding which domains should be included in the GA .
In addition , the field of geriatric oncology moves very fast and as a result many new studies have been published since the last review in 2015 .
Therefore , the objective of this systematic review is to evaluate which domains of the GA could predict patient-related treatment outcomes of older patients with cancer and thereby should be included in a GA .