The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .
Antihypertensive effect of enalapril as first-step treatment of mild and moderate uncomplicated essential hypertension. Evaluation by two methods of blood pressure measurement.
The new angiotensin converting enzyme inhibitor enalapril ( MK-421 ) , was given in a single daily dose of 20 mg to 53 patients with uncomplicated essential hypertension . Its effects were compared with those of a placebo given to 47 patients on a double-blind r and omized basis . The blood pressure was measured in all patients by a physician , using a mercury sphygmomanometer , and by an automatic device in the absence of the physician . After 15 days of treatment , enalapril induced a significant reduction in systolic blood pressure ( 161.4 + /- 13 versus 145.1 + /- 15 , p less than 0.001 ) and in diastolic blood pressure ( 103.3 + /- 6 versus 92.9 + /- 8 , p less than 0.001 ) measured by the physician . The magnitude of the fall in blood pressure was identical after 30 days of active treatment . The reduction in blood pressure induced by enalapril was similarly detected by both methods of measurement , despite the fact that blood pressure values were higher when measured by the physician . A placebo effect was observed with the physician 's values that was not present with the automatically recorded values . A very significant correlation between blood pressure values obtained by these two methods was observed . However , among nine of 53 patients treated with enalapril , a difference in the decrease of blood pressure of 10 mm Hg or more was noted between the two methods of measurement . The decrease in blood pressure occurred with no change noted in the pulse rate or orthostatic hypotension . Plasma renin activity increased after treatment . No changes were observed in creatinine clearance and plasma electrolyte levels
The data do not suggest that any one ACE inhibitor is better or worse at lowering BP .
ACE inhibitor doses above Max did not significantly lower BP more than Max .
There are no clinical ly meaningful BP lowering differences between different ACE inhibitors .
BACKGROUND ACE inhibitors are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure ( BP ) , heart rate and withdrawals due to adverse effects ( WDAE ) .
OBJECTIVES To quantify the dose-related systolic and /or diastolic BP lowering efficacy of ACE inhibitors versus placebo in the treatment of primary hypertension .