Unlike the conclusions of the revised Cochrane review the export group set up by the Section on Paediatrics , European Academy of Allergology and Clinical Immunology ( SP-EAACI ) do not find that the exclusion of the four trials dem and s a change of the previous recommendations regarding primary dietary prevention of allergic diseases .
Based on analysis of published peer- review ed observational and interventional studies the results still indicate that breastfeeding is highly recommended for all infants irrespective of atopic heredity .
A dietary regimen is effective in the prevention of allergic diseases in high-risk infants , particularly in early infancy regarding food allergy and eczema .
The most effective dietary regimen is exclusively breastfeeding for at least 4 - 6 months or , in absence of breast milk , formulas with documented reduced allergenicity for at least the first 4 months , combined with avoidance of solid food and cow 's milk for the first 4 months
A Prospective Study of Cow's Milk Allergy in Exclusively Breast‐Fed Infants
ABSTRACT . A cohort of 1749 newborns in the municipality of Odense were followed prospect ively for the development of  cow 's milk allergy ( CMA )  during their first year of life . Altogether 39 fulfilled the criteria for CMA ( 2.2 % ) . Out of the 39 infants , 17 developed symptoms of CMA during breast‐feeding , in all cases before the age of 3 months . Nine of these were solely breast‐fed at the time of diagnosis , giving a one year incidence of CMA in exclusively breastfed infants of 0.5 % ( 9/1 749 ) in a study population with a frequency of exclusive breast‐feeding of 52 % at 3 months of age . None of the infants had signs of CMA in the neonatal period . Review of records from the newborn nursery revealed that all 9 infants had been exposed to cow 's milk formula in amounts corresponding to approximately 0.4‐3.0 g of Beta‐lactoglobulin ( BLG ) during the first three days of life . Human milk sample s were analyzed by enzyme‐linked immunosorbent assay ( ELISA ) for the content of bovine BLG . Detectable amounts ( 0.5–45 ng/ml ) were found in 3/9 sample s of human milk against which the infants reacted clinical ly . Analysis of the size distribution by high pressure liquid gel permeation chromatography in combination with ELISA indicated a molecular weight of BLG corresponding to that of monomeric BLG ( 18 kD ) . Possibly early inadvertent and occasional exposure to cow 's milk proteins may initiate sensitization in predisposed neonates . Subsequent exposure to minute amounts of bovine milk proteins in human milk may act as booster doses eliciting allergic reactions
Unlike the conclusions of the revised Cochrane review the export group set up by the Section on Paediatrics , European Academy of Allergology and Clinical Immunology ( SP-EAACI ) do not find that the exclusion of the four trials dem and s a change of the previous recommendations regarding primary dietary prevention of allergic diseases .
Based on analysis of published peer- review ed observational and interventional studies the results still indicate that breastfeeding is highly recommended for all infants irrespective of atopic heredity .
A dietary regimen is effective in the prevention of allergic diseases in high-risk infants , particularly in early infancy regarding food allergy and eczema .
The most effective dietary regimen is exclusively breastfeeding for at least 4 - 6 months or , in absence of breast milk , formulas with documented reduced allergenicity for at least the first 4 months , combined with avoidance of solid food and cow 's milk for the first 4 months