However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .
Effects of dietary α-linolenic acid from blended oils on biochemical indices of coronary heart disease in indians
PUFA of the n−6 and n−3 series have beneficial effects on key risk factors of coronary heart disease ( CHD ) . Our earlier studies on the intake of FA and on the FA composition of plasma and platelet phospholipids suggested the need to improve the n−3 PUFA nutritional status in the Indian population . The present long-term study was conducted on 80 middle-aged Indian subjects ( 40 men and 40 women ) using the subjects ' own home-prepared diets to evaluate the effects of dietary n−3 PUFA on biochemical indices of CHD risk .  Substitution of Blend G ( equal proportions of groundnut and canola oils ) for groundnut oil or substitution of Blend S ( equal proportions of sunflower and canola oils ) for sunflower oil  increased α-linolenic acid ( ALNA ) fourfold and decreased the linoleic acid (LA)/ALNA ratio from 35 to 6 and 65 to 9 , respectively . Twelve subjects ( six men and six women ) who received Blend G were switched back to groundnut oil and were administered 0.3 g daily of long-chain ( LC ) n−3 PUFA from fish oil . At the end of the trial period for both blends in both sexes , plasma lipid and apolipoprotein levels had not changed , and ADP-induced aggregation had decreased . In plasma and platelet phospholipids , LA as well as LCn-3 PUFA had increased , suggesting competition between LA and ALNA for metabolism into the respective LC-PUFA . Fish oil supplementation  increased LCn-3 PUFA in plasma and platelet phospholipids , decreased ADP-induced platelet aggregation , and increased plasma cholesterol . On the basis of the increased LCn-3 PUFA in plasma phospholipids , it was calculated that 0.75 % energy ( en% ) ( 2.2 g ) ALNA ( from vegetable oils ) may be required to increase LCn-3 PUFA to about the same extent as 0.1 en% ( 0.3 g ) LCn-3 PUFA ( from fish oils ) . Since both n−6 and n−3 PUFA play a critical role in fetal growth and development and in the programming of diet-related chronic diseases in adults , an improvement in the n−3 PUFA nutritional status in cereal-based diets through long-term use of cooking oils containing 25–40 % LA and 4 % ALNA may contribute to the prevention of CHD in Indians
However , subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake , LA might increase the blood CRP level .
Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet .
Our meta- analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers .
However , the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP
PURPOSE The aim of the present study was to investigate the effect of increasing dietary linoleic acid ( LA ) intake on the blood concentrations of inflammatory markers including cytokines , acute phase reactants and adhesion molecules in adults .