Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Impact of Three Doses of Vitamin D3 on Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren
Objective We investigated the daily dose of vitamin D needed to achieve serum 25-hydroxyvitamin D [ 25(OH)D ] sufficiency among schoolchildren at risk for deficiency . Study Design The Daily D Health Study was a r and omized double-blind vitamin D supplementation trial among racially/ethnically diverse schoolchildren ( n = 685 ) in the northeastern United States . Children were supplemented with vitamin D3 at 600 , 1000 , or 2000 IU/d for 6 months . Measurements included serum 25(OH)D at baseline ( October to December ) , 3 months ( January to March ) , 6 months ( April to June ) , and 12 months ( 6 months after supplementation ) . Results At baseline , mean ± st and ard deviation serum 25(OH)D level was 22.0 ± 6.8 ng/mL , with 5.5 % severely vitamin D deficient ( < 12 ng/mL ) , 34.1 % deficient ( 12 to 19 ng/mL ) , 49.0 % insufficient ( 20 to 29 ng/mL ) , and 11.4 % sufficient ( ≥30 ng/mL ) . The lowest levels of serum 25(OH)D were found among black ( 17.9 ± 6.7 ng/mL ) and Asian children ( 18.9 ± 4.8 ng/mL ) , with no baseline differences by weight status . Serum 25(OH)D increased over 6 months in all three dose groups . The 2000 IU/d group achieved a higher mean serum 25(OH)D level than the other two dose groups ( 33.1 vs 26.3 and 27.5 ng/mL ; P < 0.001 ) , with 59.9 % of this group attaining sufficiency at 3 months and only 5.3 % remaining severely deficient/deficient at 6 months . All dose groups demonstrated a fall in 25(OH)D at 12 months . Conclusions Children at risk for vitamin D deficiency benefited from daily sustained supplementation of 2000 IU/d compared with lower doses closer to the current recommended daily allowance for vitamin D intake . This benefit occurred over the winter months , when serum 25(OH)D level tend to fall
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .