Combination therapy studies of third-line treatments were rare and centered on medication with PTNS .
Combination therapy , with certain first , second , and third-line OAB therapies , appears to be efficacious .
AIMS Overactive bladder ( OAB ) affects over 17 % of the population and significantly effect the health-related quality of life .
The treatments for OAB include first line ( lifestyle modification , pelvic floor muscle training ) , second line ( anticholinergic or beta-3 agonist medications ) , and third line therapies ( intradetrusor botulinum toxin injection , sacral neurostimulation [ SNM ] , or percutaneous tibial nerve stimulation [ PTNS ] ) .
For those with urinary incontinence secondary to OAB , complete continence is the goal of therapy , though cure rates are only 5 % to 40 % .
The use of combination therapies can be employed in refractory OAB , however , the efficacy of pooled modalities is relatively unknown .
Our objective was to determine the volume of data supporting combination therapy in treating OAB .
Anticholinergic drugs, bladder retraining and their combination for urge urinary incontinence: a pilot randomised trial
Bladder retraining and anticholinergic drugs in women with urge urinary incontinence need to be compared . Women with urge urinary incontinence were recruited by advertisements , from primary care and from a urogynaecology clinic . Women were r and omised using a web page to bladder retraining , anticholinergic drugs or both and followed up at 3 and 12 months . No blinding was attempted . The primary outcomes were the trial process and the Overactive Bladder Question naire ( OAB-q ) quality -of-life measure . Recruitment was much slower than anticipated . There were no differences in the OAB-q at 12 months ( 87.9 SD 11.6 bladder retraining , 81.6 SD 19.3 drug therapy and 88.9 SD 9.9 combination ) but dry mouth was more common in those taking drugs . It is feasible to run a pragmatic r and omised trial with 12-month follow-up for women with urinary urge incontinence . This will require about 500 participants per arm
Combination therapy studies of third-line treatments were rare and centered on medication with PTNS .
Combination therapy , with certain first , second , and third-line OAB therapies , appears to be efficacious .
AIMS Overactive bladder ( OAB ) affects over 17 % of the population and significantly effect the health-related quality of life .
The treatments for OAB include first line ( lifestyle modification , pelvic floor muscle training ) , second line ( anticholinergic or beta-3 agonist medications ) , and third line therapies ( intradetrusor botulinum toxin injection , sacral neurostimulation [ SNM ] , or percutaneous tibial nerve stimulation [ PTNS ] ) .
For those with urinary incontinence secondary to OAB , complete continence is the goal of therapy , though cure rates are only 5 % to 40 % .
The use of combination therapies can be employed in refractory OAB , however , the efficacy of pooled modalities is relatively unknown .
Our objective was to determine the volume of data supporting combination therapy in treating OAB .