Criterion validity for three of these measures was established in NSCLC but not the reliability or responsiveness .
Background The measurement properties of instruments used to assess functional capacity , physical activity and muscle strength in participants with non-small cell lung cancer ( NSCLC ) have not been systematic ally review ed .
Method Objectives : To identify outcome measures used to assess these outcomes in participants with NSCLC ; and to evaluate , synthesis e and compare the measurement properties of the outcome measures identified .
Updated assessment of the six-minute walk test as predictor of acute radiation-induced pneumonitis.
PURPOSE To assess the utility of the 6-minute walk test ( 6MWT ) as a predictor of  symptomatic radiation-induced pneumonitis ( RP ) .  METHODS As part of a prospect i ve trial to study radiation-induced lung injury , 53 patients receiving thoracic radiotherapy ( RT ) underwent a pre-RT 6MWT , pulmonary function tests ( PFTs ) , and had > or=3-month follow-up for prospect i ve assessment of Grade 2 or worse RP ( requiring medications or worse ) . Dosimetric parameters ( e.g. , the percentage of lung receiving > or=30 Gy ) were extracted from the lung dose-volume histogram . The correlations between the 6MWT and PFT results were assessed using Pearson 's correlation . The receiver operating characteristic technique was used in patient subgroups to evaluate the predictive capacities for RP of the dosimetric parameters , 6MWT results , and PFT results , or the combination ( using discriminant analysis ) of all three metrics . ROCKIT software was used to compare the receiver operating characteristic areas between each predictive model . The association of the decline in 6MWT with the development of RP was evaluated using Fisher 's exact test . RESULTS The pre-RT PFT and 6MWT results correlated weakly ( r = 0.44 - 0.57 , p < or= 0.001 ) , suggesting that they measure somewhat different physiologic functions . Of the 53 patients , 9 ( 17 % ) developed RP . The dose-volume histogram-based dosimetric parameters were the best single-metric model for predicting RP ( e.g. , percentage of lung receiving > or=30 Gy , receiver operating characteristic area 0.73 , p = 0.03 ) . Including the PFT or 6MWT results with the percentage of lung receiving > or=30 Gy did not improve the predictions . The predictive abilities of dosimetric-based models improved when the analysis was restricted to those patients whose tumors were not causing regional lung dysfunction . No correlation was found between the decline in the 6MWT result and the RP rate ( p = 0.6 ) . CONCLUSION Although the PFTs and 6MWT are related to each other , the correlation coefficients were weak , suggesting that they could be measuring different physiologic functions . In the present data set , the addition of the PFTs or 6MWT did not increase the ability of the dosimetric parameters to predict for acute symptomatic RP . Additional work is needed to better underst and the interaction among the PFT results , exercise tolerance ( 6MWT ) , and the risk of RT-induced  lung dysfunction
Criterion validity for three of these measures was established in NSCLC but not the reliability or responsiveness .
Background The measurement properties of instruments used to assess functional capacity , physical activity and muscle strength in participants with non-small cell lung cancer ( NSCLC ) have not been systematic ally review ed .
Method Objectives : To identify outcome measures used to assess these outcomes in participants with NSCLC ; and to evaluate , synthesis e and compare the measurement properties of the outcome measures identified .