In general , stimulants improved driving performance in ADHD patients ( either in RCTs conducted in simulators and /or cars ) .
MPH-OROS  improved driving performance compared with MAS-XR , placebo , or no-drug conditions .
Although MPH-OROS and MPH-IR produced similar improvements during the day , MPH-IR lost its efficacy in the evening .
MAS-XR also improved driving performance , but worsened driving performance in the evening .
Studies with ATX report conflicting results .
Improvement was more consistent in teenagers and young adults .
In general , treatment with psychostimulants or ATX in therapeutic dosages had no negative impact on driving performance of ADHD patients .
To conclude , treatment with stimulants in therapeutic doses improves driving performance in ADHD patients , especially teenagers and young adults
Adults with Attention Deficit Hyperactivity Disorder ( ADHD ) , especially teenagers and young adults , show important car driving impairments , including risky driving , accidents , fines and suspension of driver׳s license .
We systematic ally review ed the efficacy of stimulant and non-stimulant drugs on driving performance of ADHD patients .
Long-Acting Methylphenidate Reduces Collision Rates of Young Adult Drivers With Attention-Deficit/Hyperactivity Disorder
Abstract This study investigated whether methylpheni date delivered through a long-acting transdermal system ( MTS ) would reduce collision rates of young adult drivers with attention-deficit/hyperactivity disorder ( ADHD ) . Seventeen young adults completing the study ( mean [ SD ] age , 20.82 [ 2.40 ] years ; 14 men and 13 white ) met the following inclusion criteria : ADHD diagnoses but not routinely taking ADHD medication , previously responsive to ADHD medication , active drivers with more than 1 collision or citation in the past 2 years , and no significant comorbidities . In this open-labeled , crossover design drivers were r and omly assigned either to the no-medication condition for 3 months and then MTS for 3 months or to the reverse sequence . In-car video monitoring of routine driving occurred during these 6 months . At baseline and after each condition , participants completed the Conners Adult ADHD Rating Scale and the Cox Assessment of Risky Driving Scale , and their blood pressure , heart rate , and body weight were monitored . Compared with the no-medication condition , participants in the MTS condition self-reported fewer total ADHD ( P < 0.04 ) and inattentive symptoms ( P = 0.014 ) and a trend for risky driving behaviors ( P = 0.059 ) and had fewer video-recorded collisions ( P < 0.005 ) and other problematic driving events . There were no significant changes in blood pressure , heart rate , or body weight across conditions or any significant skin reactions to the MTS patch . This is the first study demonstrating that long-acting methylpheni date improves activities of daily living among young adults with ADHD . Specifically , methylpheni date improved safety in routine driving while reducing ADHD symptoms with minimal adverse effects
In general , stimulants improved driving performance in ADHD patients ( either in RCTs conducted in simulators and /or cars ) .
MPH-OROS  improved driving performance compared with MAS-XR , placebo , or no-drug conditions .
Although MPH-OROS and MPH-IR produced similar improvements during the day , MPH-IR lost its efficacy in the evening .
MAS-XR also improved driving performance , but worsened driving performance in the evening .
Studies with ATX report conflicting results .
Improvement was more consistent in teenagers and young adults .
In general , treatment with psychostimulants or ATX in therapeutic dosages had no negative impact on driving performance of ADHD patients .
To conclude , treatment with stimulants in therapeutic doses improves driving performance in ADHD patients , especially teenagers and young adults
Adults with Attention Deficit Hyperactivity Disorder ( ADHD ) , especially teenagers and young adults , show important car driving impairments , including risky driving , accidents , fines and suspension of driver׳s license .
We systematic ally review ed the efficacy of stimulant and non-stimulant drugs on driving performance of ADHD patients .