Data from large , epidemiologic studies support the existence of an association between  artificially-sweetened beverage  consumption and weight gain in children .
Epidemiological data have demonstrated an association between artificial sweetener use and  weight gain .
Evidence of a causal relationship linking artificial sweetener use to weight gain and other metabolic health effects is limited .
However , recent animal studies provide intriguing information that supports an active metabolic role of artificial sweeteners .
This systematic review examines the current literature on  artificial sweetener consumption in children and its health effects .
Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes.
OBJECTIVE To investigate the effect of 3-months ' daily administration of high doses of sucralose , a non-nutritive sweetener , on glycemic control in subjects with type 2 diabetes . DESIGN A multicenter , double-blind , placebo-controlled , r and omized study , consisting of a 6-week screening phase , a 13-week test phase , and a 4-week follow-up phase . SUBJECTS/ SETTING Subjects with type 2 diabetes ( age range 31 to 70 years ) entered the test phase of this study ; 128 subjects completed the study . The subjects were recruited from 5 medical centers across the United States and were , on average , obese . INTERVENTION Subjects were r and omly assigned to receive either placebo ( cellulose ) capsules ( n=69 ) or 667 mg encapsulated sucralose ( n=67 ) daily for the 13-week test phase . All subjects blindly received placebo capsules during the last 4 weeks of the screening phase and for the entire 4-week follow-up phase . MAIN OUTCOME MEASURES Glycated hemoglobin ( HbA1c ) , fasting plasma glucose , and fasting serum C-peptide were measured approximately every 2 weeks to evaluate blood glucose homeostasis . Data were analyzed by analysis of variance using repeated measures . RESULTS There were no significant differences between the sucralose and placebo groups in HbA1c , fasting plasma glucose , or fasting serum C-peptide changes from baseline . There were no clinical ly meaningful differences between the groups in any safety measure . CONCLUSIONS This study demonstrated that , similar to cellulose , sucralose consumption for 3 months at doses of 7.5 mg/kg/day , which is approximately three times the estimated maximum intake , had no effect on glucose homeostasis in individuals with type 2 diabetes . Additionally , this study showed that sucralose was as well-tolerated by the study subjects as was the placebo
Data from large , epidemiologic studies support the existence of an association between  artificially-sweetened beverage  consumption and weight gain in children .
Epidemiological data have demonstrated an association between artificial sweetener use and  weight gain .
Evidence of a causal relationship linking artificial sweetener use to weight gain and other metabolic health effects is limited .
However , recent animal studies provide intriguing information that supports an active metabolic role of artificial sweeteners .
This systematic review examines the current literature on  artificial sweetener consumption in children and its health effects .