Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .
Effect of zinc supplementation on serum homocysteine in type 2 diabetic patients with microalbuminuria.
OBJECTIVES Elevated homocysteine levels are considered to be an independent risk factor for cardiovascular complications in diabetic patients . The aim of this study was to find out if zinc supplementation improves homocysteine levels , which may exert vascular-protective effects in type 2 diabetes subjects with microalbuminuria . METHODS In a r and omized , double-blind , controlled , crossover study , 50 type 2 diabetic patients with microalbuminuria were subdivided into two groups and supplemented with 30 mg/d of zinc ( group 1 ) or placebo ( group 2 ) for three months with a four-week wash out period . Serum creatinine , vitamin B(12 ) , folate , fasting plasma glucose , HbA1c , lipid profiles , zinc , homocysteine levels and r and om urine albumin were measured before and after the first and second phase of the study in all participants . RESULTS Mean serum zinc was significantly increased after zinc supplementation ( from 76 + /- 16 mug/dl to 93 + /- 20 microg/dl ; p < 0.05 ) , while there was no change in the placebo group ( 75 + /- 16 microg/dl to 75 + /- 15 microg/dl ) . With  zinc supplementation  , homocysteine levels reduced significantly ( from 13.71 + /- 3.84 mumol/l to 11.79 + /- 3.06 mumol/l ; p < 0.05 ) , which did not occur on placebo ( from 12.59 + /- 2.13 mumol/l to 13.36 + /- 2.03 mumol/l ) . Simple regression was used to show a positive correlation between urine albumin excretion and serum homocysteine ( r = 0.37 , p = 0.023 ) . Vitamin B(12 ) and folate levels increased significantly in patients who received zinc in comparison to those who received placebo . A negative correlation was observed between homocysteine and vitamin B(12 ) concentration ( r = -0.36 , p = 0.025 ) . CONCLUSION Zinc supplementation reduced serum homocysteine and increased vitamin B(12 ) and folate concentrations in type 2 diabetic patients with microalbuminuria
Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation .
This first comprehensive systematic review and meta- analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation  has beneficial effects on glycaemic control and promotes healthy lipid parameters .
The number of people with diabetes and pre-diabetes are exponentially increasing .
Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes .
The present study aims to systematic ally evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes .