Probiotics , fennel extract  and  spinal manipulation  show promise to alleviate symptoms of colic , although some concerns remain .
Background Infantile colic is a distressing condition characterised by excessive crying in the first few months of life .
The aim of this research was to up date the synthesis of evidence of complementary and alternative medicine ( CAM ) research literature on infantile colic and establish what evidence is currently available .
Efficacy of chiropractic manual therapy on infant colic: a pragmatic single-blind, randomized controlled trial.
OBJECTIVE The purpose of this study was to determine the efficacy of chiropractic manual therapy for infants with unexplained crying behavior  and if there was any effect of parental reporting bias . METHODS Infants with unexplained persistent crying ( infant colic ) were recruited between October 2007 and November 2009 at a chiropractic teaching clinic in the United Kingdom . Infants younger than 8 weeks were r and omized to 1 of 3 groups : ( i ) infant treated , parent aware ; ( ii ) infant treated , parent unaware ; and ( iii ) infant not treated , parent unaware . The primary outcome was a daily crying diary completed by parents over a period of 10 days . Treatments were pragmatic , individualized to examination findings , and consisted of chiropractic manual therapy of the spine . Analysis of covariance was used to investigate differences between groups . RESULTS One hundred four patients were r and omized . In parents blinded to treatment allocation , using 2 or less hours of crying per day to determine a clinical ly significant improvement in crying time , the increased odds of improvement in treated infants compared with those not receiving treatment were statistically significant at day 8 ( adjusted odds ratio [ OR ] , 8.1 ; 95 % confidence interval [ CI ] , 1.4 - 45.0 ) and at day 10 ( adjusted OR , 11.8 ; 95 % CI , 2.1 - 68.3 ) . The number needed to treat was 3 . In contrast , the odds of improvement in treated infants were not significantly different in blinded compared with nonblinded parents ( adjusted ORs , 0.7 [ 95 % CI , 0.2 - 2.0 ] and 0.5 [ 95 % CI , 0.1 - 1.6 ] at days 8 and 10 , respectively ) . CONCLUSIONS In this study , chiropractic manual therapy improved crying behavior in infants with colic . The findings showed that knowledge of treatment by the parent did not appear to contribute to the observed treatment effects in this study . Thus , it is unlikely that observed treatment effect is due to bias on the part of the reporting parent
Probiotics , fennel extract  and  spinal manipulation  show promise to alleviate symptoms of colic , although some concerns remain .
Background Infantile colic is a distressing condition characterised by excessive crying in the first few months of life .
The aim of this research was to up date the synthesis of evidence of complementary and alternative medicine ( CAM ) research literature on infantile colic and establish what evidence is currently available .