Several studies of good quality demonstrated changes in lifestyle habits arising from the provision of genetic interventions .
The most promising lifestyle changes were changes in nutrition .
Conclusions : It is possible to facilitate behaviour change using genetic testing as the catalyst .
Background : Study ing the impact of  genetic testing interventions on lifestyle behaviour change  has been a priority area of research in recent years .
Substantial heterogeneity exists in the results and conclusions of this literature , which has yet to be explained using vali date d behaviour change theory and an assessment of the quality of genetic interventions .
The theory of planned behaviour ( TPB ) helps to explain key contributors to behaviour change .
It has been hypothesized that personalization could be added to this theory to help predict changes in health behaviours .
Purpose : This systematic review provides a detailed , comprehensive identification , assessment , and summary of primary research articles pertaining to  lifestyle behaviour change  ( nutrition , physical activity , sleep , and smoking ) result ing from  genetic testing interventions .
The present review further aims to provide in-depth analyses of studies conducted to date within the context of the TPB and the quality of genetic interventions provided to participants while aim ing to determine whether or not genetic testing facilitates changes in lifestyle habits .
This review is timely in light of a recently published “ call-to-action ” paper , highlighting the need to incorporate the TPB into personalized healthcare behaviour change research .
Health Behavior Changes After Genetic Risk Assessment for Alzheimer Disease: The REVEAL Study
Risk information for Alzheimer disease ( AD ) may be communicated through susceptibility gene disclosure , even though this is not currently in clinical use . The REVEAL Study is the first r and omized clinical trial of risk assessment for AD with apolipoprotein E ( APOE ) genotype and numerical risk estimate disclosure . We examined whether APOE genotype and numerical risk disclosure to asymptomatic individuals at high risk for AD alters health behaviors . One hundred sixty-two participants were r and omized to either intervention ( APOE disclosure ) or control ( no genotype disclosure ) groups . Subjects in both groups received numerical lifetime risk estimates of future AD development based on sex and family history of AD . The intervention group received their APOE genotype . Subjects were informed that no proven preventive measures for AD existed and given an information sheet on preventative therapies under investigation . Participants who learned they were ϵ4 positive were significantly more likely than ϵ4 negative participants to report AD-specific health behavior change 1 year after disclosure ( adjusted odds ratio : 2.73 ; 95 % confidence interval : 1.14 , 6.54 ; P=0.02 ) . Post hoc analyses revealed similar significant associations between numerical lifetime risk estimates and self-report of AD-specific health behavior change . Despite lack of preventive measures for AD , knowledge of APOE genotype , numerical lifetime risk , or both , influences health behavior
Several studies of good quality demonstrated changes in lifestyle habits arising from the provision of genetic interventions .
The most promising lifestyle changes were changes in nutrition .
Conclusions : It is possible to facilitate behaviour change using genetic testing as the catalyst .
Background : Study ing the impact of  genetic testing interventions on lifestyle behaviour change  has been a priority area of research in recent years .
Substantial heterogeneity exists in the results and conclusions of this literature , which has yet to be explained using vali date d behaviour change theory and an assessment of the quality of genetic interventions .
The theory of planned behaviour ( TPB ) helps to explain key contributors to behaviour change .
It has been hypothesized that personalization could be added to this theory to help predict changes in health behaviours .
Purpose : This systematic review provides a detailed , comprehensive identification , assessment , and summary of primary research articles pertaining to  lifestyle behaviour change  ( nutrition , physical activity , sleep , and smoking ) result ing from  genetic testing interventions .
The present review further aims to provide in-depth analyses of studies conducted to date within the context of the TPB and the quality of genetic interventions provided to participants while aim ing to determine whether or not genetic testing facilitates changes in lifestyle habits .
This review is timely in light of a recently published “ call-to-action ” paper , highlighting the need to incorporate the TPB into personalized healthcare behaviour change research .