Although this study did not consider placebo effect and has high IPSS baseline scores , this study clarifies that low-dose tamsulosin has generally positive effect and safety in treatment of LUTS and could be a suitable option as an initial treatment , especially for patients with low body mass index , as is typical of Asian people
PURPOSE In Asian countries , low-dose tamsulosin ( 0.2 mg ) is used widely but this dose has been less popular than 0.4 mg tamsulosin or other types of alpha blockers .
The aim of this study was to investigate the efficacy and safety of low-dose tamsulosin by systematic review and meta- analysis .
Transition zone ratio and prostate-specific antigen density as predictors of the response of benign prostatic hypertrophy to alpha blocker and anti-androgen therapy.
OBJECTIVE To determine whether transrectal ultrasonography ( TRUS ) can predict the clinical response of patients with benign prostatic hypertrophy ( BPH ) to alpha 1-blocker and anti- and rogen therapy . PATIENTS AND METHODS From April 1994 to July 1995 , 128 patients with BPH were r and omized to treatment for 6 months with either tamsulosin ( a long-acting selective alpha 1-blocker ) or allylestrenol ( an anti- and rogen ) , with 64 patients receiving tamsulosin ( 0.2 mg/day ) and 64 receiving allylestrenol ( 50 mg/day ) . The results of TRUS , uroflowmetry and the American Urologic Association ( AUA ) symptom score were compared before and after treatment . TRUS was used to calculate the transition zone ( TZ ) volume , transition zone ratio ( TZ ratio = TZ volume/total prostate volume ) , total prostate volume and prostate-specific antigen density ( PSAD ) . RESULTS Both groups showed a statistically significant improvement in the AUA symptom score , quality -of-life ( QOL ) score and peak urinary flow rate ( Qmax ) at 6 months ( P < 0.001 ) . In the tamsulosin group , there was a significant negative correlation between the pretreatment PSAD and the percentage change in Qmax ( r = -0.640 , P < 0.001 ) , while there was a positive correlation between PSAD and the percentage change in the AUA symptom score ( r = 0.589 , P < 0.001 ) . On the other h and , the allylestrenol group showed a significant positive correlation between PSAD and the percentage change in Qmax ( r = 0.397 , P < 0.01 ) and a negative correlation between PSAD and the AUA symptom score ( r = -0.313 , P < 0.01 ) . CONCLUSION Patients with a high pretreatment PSAD responded well to anti- and rogen therapy , while those with a low PSAD responded better to alpha 1-blocker therapy
Although this study did not consider placebo effect and has high IPSS baseline scores , this study clarifies that low-dose tamsulosin has generally positive effect and safety in treatment of LUTS and could be a suitable option as an initial treatment , especially for patients with low body mass index , as is typical of Asian people
PURPOSE In Asian countries , low-dose tamsulosin ( 0.2 mg ) is used widely but this dose has been less popular than 0.4 mg tamsulosin or other types of alpha blockers .
The aim of this study was to investigate the efficacy and safety of low-dose tamsulosin by systematic review and meta- analysis .