Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Estimation of the dietary requirement for vitamin D in white children aged 4-8 y: a randomized, controlled, dose-response trial.
BACKGROUND Children in northern latitudes are at high risk of vitamin D deficiency during winter because of negligible dermal vitamin D3 production . However , to our knowledge , the dietary requirement for maintaining the nutritional adequacy of vitamin D in young children has not been investigated . OBJECTIVE We aim ed to establish the distribution of vitamin D intakes required to maintain winter serum 25-hydroxyvitamin D [ 25(OH)D ] concentrations above the proposed cutoffs ( 25 , 30 , 40 , and 50 nmol/L ) in white Danish children aged 4 - 8 y living at 55 ° N. DESIGN In a double-blind , r and omized , controlled trial 119 children ( mean age : 6.7 y ) were assigned to 0 ( placebo ) , 10 , or 20 μg vitamin D3/d supplementation for 20 wk . We measured anthropometry , dietary vitamin D , and serum 25(OH)D with liquid chromatography-t and em mass spectrometry at baseline and endpoint . RESULTS The mean ± SD baseline serum 25(OH)D was 56.7 ± 12.3 nmol/L ( range : 28.7 - 101.4 nmol/L ) . Serum 25(OH)D increased by a mean ± SE of 4.9 ± 1.3 and 17.7 ± 1.8 nmol/L in the groups receiving 10 and 20 μg vitamin D3/d , respectively , and decreased by 24.1 ± 1.2 nmol/L in the placebo group ( P < 0.001 ) . A nonlinear model of serum 25(OH)D as a function of total vitamin D intake ( diet and supplements ) was fit to the data . The estimated vitamin D intakes required to maintain winter serum 25(OH)D > 30 ( avoiding deficiency ) and > 50 nmol/L ( ensuring adequacy ) in 97.5 % of participants were 8.3 and 19.5 μg/d , respectively , and 4.4 μg/d was required to maintain serum 25(OH)D > 40 nmol/L in 50 % of participants . CONCLUSIONS Vitamin D intakes between 8 and 20 μg/d are required by white 4- to 8-y-olds during winter in northern latitudes to maintain serum 25(OH)D > 30 - 50 nmol/L depending on chosen serum 25(OH)D threshold . This trial was registered at clinical trials.gov as NCT02145195
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .