Collectively , the literature reveals pre clinical and clinical evidence for various phytomedicines modulating GABA-pathways , with comparative anxiolytic effect to the current array of pharmaceuticals , along with good safety and tolerability profiles
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress , characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia .
Gamma-aminobutyric acid ( GABA ) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety .
Although current pharmaceutical treatments are often efficacious , they may cause undesirable side effects including cognitive decrements and withdrawal symptoms .
Plant-based " phytomedicines " may provide novel treatment options , to act as an adjunctive or alternative to existing anxiolytic medications .
As such , we conducted a systematic review to assess the current body of literature on anxiolytic phytomedicines and /or phytoconstituents .
Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract
Chronic stress has been associated with a number of illnesses , including obesity . Ashwag and ha is a well-known adaptogen and known for reducing stress and anxiety in humans . The objective of this study was to evaluate the safety and efficacy of a st and ardized root extract of Ashwag and ha through a double-blind , r and omized , placebo-controlled trial . A total of 52 subjects under chronic stress received either Ashwag and ha ( 300 mg ) or placebo twice daily . Primary efficacy measures were Perceived Stress Scale and Food Cravings Question naire . Secondary efficacy measures were Oxford Happiness Question naire , Three-Factor Eating Question naire , serum cortisol , body weight , and body mass index . Each subject was assessed at the start and at 4 and 8 weeks . The treatment with Ashwag and ha result ed in significant improvements in primary and secondary measures . Also , the extract was found to be safe and tolerable . The outcome of this study suggests that Ashwag and ha root extract can be used for body weight management in adults under chronic stress
Collectively , the literature reveals pre clinical and clinical evidence for various phytomedicines modulating GABA-pathways , with comparative anxiolytic effect to the current array of pharmaceuticals , along with good safety and tolerability profiles
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress , characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia .
Gamma-aminobutyric acid ( GABA ) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety .
Although current pharmaceutical treatments are often efficacious , they may cause undesirable side effects including cognitive decrements and withdrawal symptoms .
Plant-based " phytomedicines " may provide novel treatment options , to act as an adjunctive or alternative to existing anxiolytic medications .
As such , we conducted a systematic review to assess the current body of literature on anxiolytic phytomedicines and /or phytoconstituents .