Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .
Changes in inflammatory markers after sleeve gastrectomy in patients with impaired glucose homeostasis and type 2 diabetes.
BACKGROUND Bariatric surgery is an effective treatment for morbid obesity . Obesity and type 2 diabetes are associated with chronic inflammation . There is lack of data examining the effects of sleeve gastrectomy ( SG ) on inflammatory biomarkers . Our aim was to study the effects of SG on specific cytokines associated with obesity including interleukin-6 ( IL-6 ) , interleukin-10 ( IL-10 ) , leptin , adiponectin , and C-reactive protein ( CRP ) preoperatively , 1 and 6 months after surgery . METHODS A nonr and omized prospect i ve study comprising of 22 participants with impaired glucose homeostasis and type 2 diabetes undergoing SG ( body mass index 50.1 kg/m(2 ) , glycated hemoglobin [ HbA1c ] 53 mmol/mol ) .  Serial measurements of IL-6 , IL-10 , leptin , adiponectin , and CRP  were performed during oral glucose tolerance testing preoperatively , 1 and 6 months postoperatively . RESULTS We observed significant improvements at 1 and 6 months in leptin ( P≤.001 ) and CRP ( P = .003 ) after SG . We also observed a significant reduction in IL-6 at 6 months ( P = .001 ) . No statistically significant differences were observed for adiponectin and IL-10 . CONCLUSION This study is the first to examine the detailed changes in the inflammatory cytokines after SG . Our study shows significant improvements in the inflammatory biomarkers after SG in patients with impaired glucose homeostasis and type 2 diabetes
Bariatric surgery  significantly lowered inflammatory factors ; however , baseline BMI , follow-up duration and type of surgery could impact the extent of observed effects
Obesity is one of the main causes of inflammation .
Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers .
This systematic review and meta- analysis is aim ed at describing the effect of bariatric surgery on C-reactive protein ( CRP ) , interleukin-6 ( IL-6 ) , tumor necrosis factor-α ( TNF-α ) .