Results Although highlighting a general lack of high- quality real-life effectiveness observational research on these clinical ly important topics , the analysis provided insights into how identified observational studies might inform asthma guidelines developers and clinicians .
Overall , RELEVANT appeared reliable and easy to use by expert review ers .
Conclusions Using such quality appraisal tools is m and atory to assess whether specific observational real-life effectiveness studies can be used to inform guideline development and /or decision-making in clinical practice
Abstract Introduction A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology ( EAACI ) and the Respiratory Effectiveness Group ( REG ) to develop a  quality assessment tool for real-life observational research to identify high- quality real-life asthma studies that could be considered within future guideline development .
A questionnaire to assess the relevance and credibility of observational studies to inform health care decision making: an ISPOR-AMCP-NPC Good Practice Task Force report.
Evidence -based health care decisions are best informed by comparisons of all relevant interventions used to treat conditions in specific patient population s.  Observational studies are being performed to help fill evidence gaps . Widespread adoption of evidence from observational studies , however , has been limited because of various factors , including the lack of consensus regarding accepted principles for their evaluation and interpretation . Two task forces were formed to develop question naires to assist decision makers in evaluating observational studies  , with one Task Force addressing retrospective research and the other Task Force addressing prospect i ve research . The intent was to promote a structured approach to reduce the potential for subjective interpretation of evidence and drive consistency in decision making . Separately developed question naires were combined into a single question naire consisting of 33 items . These were divided into two domains : relevance and credibility . Relevance addresses the extent to which findings , if accurate , apply to the setting of interest to the decision maker . Credibility addresses the extent to which the study findings accurately answer the study question . The question naire provides a guide for assessing the degree of confidence that should be placed from observational studies and promotes awareness of the subtleties involved in evaluating those
Results Although highlighting a general lack of high- quality real-life effectiveness observational research on these clinical ly important topics , the analysis provided insights into how identified observational studies might inform asthma guidelines developers and clinicians .
Overall , RELEVANT appeared reliable and easy to use by expert review ers .
Conclusions Using such quality appraisal tools is m and atory to assess whether specific observational real-life effectiveness studies can be used to inform guideline development and /or decision-making in clinical practice
Abstract Introduction A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology ( EAACI ) and the Respiratory Effectiveness Group ( REG ) to develop a  quality assessment tool for real-life observational research to identify high- quality real-life asthma studies that could be considered within future guideline development .