The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .
Advanced age influences the dynamic changes in circulating C-reactive protein following injury
Background The concentration of C-reactive protein ( CRP ) , a biomarker of systemic inflammation , is determined by genetic , clinical and demographic factors including gender , smoking and body mass index ( BMI ) . The influence of age on CRP dynamic changes following insult has , however , been poorly characterised . Methods We used  unilateral hernia repair as a model of st and ardised insult to investigate the influence of baseline demographic and clinico-pathological factors affecting the dynamic changes in CRP , interleukin ( IL ) 6 and tumour necrosis factor-α over a time course of 48 h following injury . Results We derived CRP negativisation kinetics on 100 prospect ively enrolled male subjects with mean age of 60.6 years ( range 24–90 years ) and mean BMI of 25.7 kg/m2 ( range 17.9–37 kg/m2 ) . Patients who failed to normalise CRP to<10 mg/l at 48 h ( n=74 ) were significantly older ( p<0.001 ) , had longer surgical times ( p=0.05 ) , higher waist/hip ratio ( p=0.02 ) . Multiple regression analysis confirmed age as the only independent predictor of delayed CRP normalisation ( p=0.03 ) . Persistent CRP elevation was associated with higher peak CRP values ( p<0.001 ) , higher IL-6 concentrations at 24 ( p=0.01 ) and 48 h ( p=0.03 ) . Conclusions CRP decline following insult is delayed in elderly patients as a result of unopposed IL-6 release . Age should be routinely incorporated in the assessment of CRP response to avoid misinterpretation of age-related delay in CRP clearance with ongoing systemic inflammation
The systemic inflammatory response was normalized before or on the seventh postoperative day .
Conclusions Hernia repair elicits a systemic inflammatory response characterized by an increase in CRP , IL-6 , leukocytes , neutrophils , IL-1 , IL-10 , fibrinogen , and α1-antitrypsin and a decrease in lymphocytes and albumin .
A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair
Purpose All surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines .
The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh .