The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .
The effect of a cetylpyridinium chloride (CPC) detergent foam compared to a conventional toothpaste on plaque and gingivitis. A single blind crossover study.
A CPC-detergent formulation in a foam vehicle , was compared with a fluoride toothpaste for its ability to prevent plaque and gingivitis over a period of 12 days . Whilst refraining from all other oral hygiene procedures , the foam or toothpaste was applied to the teeth in fluoride application trays , in a group of 14 volunteers . At days 8 and 12 of this crossover study , the following assessment s were made : gingival crevicular fluid ; gingival index ; bleeding on probing ; plaque index ; plaque area . Except for plaque area at day 8 of the study , there were no significant differences between the 2 products at either day 8 or day 12 . It is therefore concluded that the CPC-detergent formulation , in its present form , does not inhibit plaque and gingivitis more effectively than a conventional fluoride toothpaste
The studies in this systematic review provide strong evidence of the antiplaque , antigingivitis effects of multiple agents .
BACKGROUND AND METHODS The author conducted a systematic review of the literature to evaluate the efficacy of  antigingivitis and antiplaque products  in six-month trials .