Pooled evidence suggested that topical anaesthetic creams ( TAs ) , tramadol , selective serotonin reuptake inhibitors ( SSRIs ) , and phosphodiesterase type 5 inhibitors ( PDE5is ) are more effective at prolonging IELT comparing with placebo .
Conclusions We recommend the initial use of dapoxetine 30 mg OD for PE because it has been tested in largest and better design ed clinical trials rather than it is more effective than the other drugs studied .
TAs and tramadol 50 mg OD can be used as a viable alternative to oral treatment with SSRIs .
PDE5is combined with SSRIs are more effective than SSRIs monotherapy but are also associated with more side effects .
Purpose The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for  premature ejaculation ( PE ) .
A Randomized Double-blind Placebo-controlled Trial to Assess the Effect of Tamarind seed in Premature Ejaculation
Background : This r and omized clinical trial was aim ed to evaluate the effect of oral use of tamarind seed powder as an herbal product in patients affected by premature ejaculation ( PE ) . Material s and Methods : In this study , 75 patients r and omized in tamarind group ( 25 patients received daily 130 mg tamarind seed powder ) , paroxetine group ( 25 patients received daily 20 mg paroxetine ) , and placebo group ( 25 patients ) . Patients received the treatment regimen for 4 weeks . The primary outcome was intravaginal ejaculatory latency time ( IELT ) . The secondary outcomes were PE diagnostic tool score , sexual function using International Index of Erectile Function ( IIEF ) , and complications . Studied sexual functions include erectile function , orgasmic function , sexual desire , intercourse satisfaction , and overall satisfaction . Results : The mean of IELT in tamarind , paroxetine , and placebo groups at baseline was 35.2 ± 26.5 , 38 ± 27.6 , and 44 ± 34.9 s and at the end of study was 49.5 ± 48.2 , 147.4 ± 209.6 , and 46.9 ± 37.6 s , respectively , which in paroxetine group significantly increased compared to other groups . IIEF scores for orgasmic function and intercourse satisfaction for paroxetine after treatment significantly increased than that of other groups . The differences between tamarind and placebo groups for studied variables were not statistically significant . The mean of increases in IELT for tamarind , paroxetine , and placebo groups was 14.35 ± 34.3 , 109.4 ± 213.4 , and 2.9 ± 9.3 s , respectively , which in paroxetine group was significantly higher than other groups and in tamarind group was significantly higher than placebo . Conclusions : Paroxetine was significantly better than tamarind seed powder and placebo although side effect in paroxetine was more frequent . IELT significantly more increased in tamarind group compared to placebo
Pooled evidence suggested that topical anaesthetic creams ( TAs ) , tramadol , selective serotonin reuptake inhibitors ( SSRIs ) , and phosphodiesterase type 5 inhibitors ( PDE5is ) are more effective at prolonging IELT comparing with placebo .
Conclusions We recommend the initial use of dapoxetine 30 mg OD for PE because it has been tested in largest and better design ed clinical trials rather than it is more effective than the other drugs studied .
TAs and tramadol 50 mg OD can be used as a viable alternative to oral treatment with SSRIs .
PDE5is combined with SSRIs are more effective than SSRIs monotherapy but are also associated with more side effects .
Purpose The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for  premature ejaculation ( PE ) .