This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .
APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention: the Pounds Lost Trial.
BACKGROUND The apolipoprotein A5 gene ( APOA5 ) is a major gene that regulates lipid metabolism and is modulated by dietary factors . A novel variant rs964184 in APOA5 was identified to be associated with lipids in genome-wide association studies . OBJECTIVE We examined whether this variant modified changes in lipid concentrations in response to a 2-y weight-loss diet intervention in a r and omized trial . DESIGN The current analyses were secondary analyses of a data set from the Pounds Lost Trial . We genotyped APOA5 rs964184 in 734 overweight or obese adults who were r and omly assigned to one of 4 diets that differed in percentages of energy derived from fat , protein , and carbohydrate for 2 y. We evaluated changes in fasting serum concentrations of total cholesterol ( TC ) , LDL cholesterol , HDL cholesterol , and triglyceride from baseline to 2 y of follow-up . RESULTS After a 2-y dietary intervention , we showed significant interactions between the APOA5 rs964184 polymorphism and dietary fat intake ( low compared with high ) in the determination of changes in TC , LDL cholesterol , and HDL cholesterol ( P-interaction = 0.007 , 0.017 , and 0.006 , respectively ) . In the low-fat intake group ( 20 % of energy derived from fat ) , carriers of the risk allele ( G allele ) exhibited greater reductions in TC and LDL cholesterol than did noncarriers ( P = 0.036 and 0.039 , respectively ) , whereas in the high-fat diet group ( 40 % of energy derived from fat ) , participants with the G allele had a greater increase in HDL cholesterol than did participants without this allele ( P = 0.038 ) . CONCLUSION Our data showed better improvement in lipid profiles from long-term low-fat diet intake in the APOA5 rs964184 risk allele
This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .