Data concerning effects of aspartame on main metabolic variables associated to diabetes and obesity do not support a beneficial related to its consumption
ABSTRACT Data about harms or benefits associated with the consumption of aspartame , a nonnutritive sweetener worldwide consumed , are still controversial .
This systematic review and meta- analysis of r and omized controlled clinical trials aim ed to assess the effect of aspartame consumption on  metabolic parameters related to diabetes and obesity .
Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in patients with type 2 diabetes
Background / objective : Artificial sweeteners were thought to be metabolically inactive , but after demonstrating that the gustatory mechanism was also localized in the small intestine , suspicions about the metabolic effects of artificial sweeteners have emerged . The objective of this study was to determine the effect of artificial sweeteners ( aspartame and sucralose ) on blood glucose , insulin , c-peptide and glucagon-like peptide-1 ( GLP-1 ) levels . Subjects/ methods : Eight newly diagnosed drug-naive type 2 diabetic patients ( mean age 51.5±9.2 years ; F/M : 4/4 ) and eight healthy subjects ( mean age 45.0±4.1 years ; F/M : 4/4 ) underwent 75 g oral glucose tolerance test ( OGTT ) . During OGTT , glucose , insulin , c-peptide and GLP-1 were measured at 15- min intervals for 120 min . The OGTTs were performed at three setting s on different days , where subjects were given 72 mg of aspartame and 24 mg of sucralose in 200 ml of water or 200 ml of water alone 15 min before OGTT in a single-blinded r and omized order . Results : In healthy subjects , the total area under the curve ( AUC ) of glucose was statistically significantly lower in the sucralose setting than in the water setting ( P=0.002 ) . There was no difference between the aspartame setting and the water setting ( P=0.53 ) . Total AUC of insulin and c-peptide was similar in aspartame , sucralose and water setting s. Total AUC of GLP-1 was significantly higher in the sucralose setting than in the water setting ( P=0.04 ) . Total AUC values of glucose , insulin , c-peptide and GLP-1 were not statistically different in three setting s in type 2 diabetic patients . Conclusions : Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in newly diagnosed type 2 diabetic patients
Data concerning effects of aspartame on main metabolic variables associated to diabetes and obesity do not support a beneficial related to its consumption
ABSTRACT Data about harms or benefits associated with the consumption of aspartame , a nonnutritive sweetener worldwide consumed , are still controversial .
This systematic review and meta- analysis of r and omized controlled clinical trials aim ed to assess the effect of aspartame consumption on  metabolic parameters related to diabetes and obesity .