There was consistent evidence from cross-sectional data of an unfavourable association between total sedentary time and insulin sensitivity .
There was also some evidence that total sedentary time was unfavourably associated with fasting insulin , insulin resistance and triglycerides .
Furthermore , there was some evidence from cross-sectional data of a favourable association between breaks in sedentary time and triglycerides .
CONCLUSION Total sedentary time was consistently shown to be associated with poorer insulin sensitivity , even after adjusting for time spent in physical activity .
OBJECTIVE We conducted a systematic review to investigate the cross-sectional and prospect i ve associations of accelerometer-measured total sedentary time and breaks in sedentary time with individual cardiometabolic biomarkers in adults ≥18years of age .
Physical Activity versus Sedentary Behavior: Associations with Lipoprotein Particle Subclass Concentrations in Healthy Adults
Background Physical activity ( PA ) and sedentary behavior ( SED ) may have independent effects on health and disease . This might be due to PA and SED having distinct effects on lipoprotein metabolism . The aim of this study was to determine associations between lipoprotein subclass particle concentrations ( -P ) and accelerometer-measured SED and moderate-to-vigorous PA ( MVPA )  in a sample of healthy adult subjects . Methods Lipoprotein subclass particle concentrations were determined by proton nuclear magnetic resonance spectroscopy , whereas SED and MVPA were measured using Agtigraph GT1 M and GT3X+ accelerometers . We obtained valid data in 73 subjects ( 30 men and 43 women , age 40.5 ± 10.6 years ; body mass index 24.0 ± 2.8 ) . Multiple regression analysis was used to determine associations ( partial correlations ) with lipoproteins . Results Positive associations were detected between SED and small VLDL-P , large LDL-P and TG ( partial r = 0.24 to 0.25 , p < .047 ) . Corresponding associations were non-significant  for MVPA ( partial r = -0.12 to 0.04 , p > .355 ) . On the contrary , MVPA was positively associated with large HDL-P , average HDL size , Apo A1 and HDL-cholesterol ( partial r = 0.28 to 0.50 , p < .027 ) , whereas SED was not ( partial r = -0.06 to 0.07 , p > .607 ) . Conclusion There might be a specific effect of SED versus MVPA on lipoprotein metabolism . However , our results must be interpreted carefully due to possible effect-modification by gender and a low sample size . Thus , our findings should be viewed as preliminary
There was consistent evidence from cross-sectional data of an unfavourable association between total sedentary time and insulin sensitivity .
There was also some evidence that total sedentary time was unfavourably associated with fasting insulin , insulin resistance and triglycerides .
Furthermore , there was some evidence from cross-sectional data of a favourable association between breaks in sedentary time and triglycerides .
CONCLUSION Total sedentary time was consistently shown to be associated with poorer insulin sensitivity , even after adjusting for time spent in physical activity .
OBJECTIVE We conducted a systematic review to investigate the cross-sectional and prospect i ve associations of accelerometer-measured total sedentary time and breaks in sedentary time with individual cardiometabolic biomarkers in adults ≥18years of age .