Despite the high risk of bias of many of the included studies , the results suggested that urinary iodine , thyroglobin , serum thyroxine , and thyroid-stimulating hormone are useful biomarkers of iodine status , at least in some groups .
BACKGROUND Biomarkers of iodine status are required to study iodine deficiency disorders in different parts of the world and to evaluate the effects of fortification strategies .
OBJECTIVE The objective was to assess the usefulness of biomarkers of iodine status in humans by systematic ally review ing intervention studies that altered iodine status .
Efficacy of daily and weekly multiple micronutrient food-like tablets for the correction of iodine deficiency in Indonesian males aged 6-12 mo.
BACKGROUND Infants are highly vulnerable to iodine deficiency , and little data exist on the effect of multiple micronutrient supplementation on their iodine status . OBJECTIVE We aim ed to compare the efficacy of daily and weekly multiple micronutrient food-like tablets ( foodLETs ) on increasing iodine status among infants . DESIGN In a double-blind , placebo-controlled trial , 133 Indonesian males aged 6 - 12 mo were r and omly assigned to 1 of 4 groups : a daily multiple-micronutrient foodLET providing the Recommended Nutrient Intake (RNI)(DMM ) , a weekly multiple-micronutrient foodLET providing twice the RNI ( WMM ) , a daily 10-mg Fe foodLET ( DI ) , or placebo .  Urinary iodine ( UI ) concentrations were measured at baseline and at 23 wk . RESULTS At baseline , the average UI concentration ( 1.37 micromol/L ) was within the normal range , and 30.8 % of subjects had iodine deficiency ( UI < 0.79 micromol/L ) . At 23 wk , the DMM group had the highest increment in UI ; however , after adjustment for initial UI , the changes in UI were not significantly different between the 4 groups ( P = 0.39 ) . Initial UI correlated inversely with the changes in UI ( P < 0.001 ) . The DMM group had the greatest reduction and increment in the proportion of iodine-deficient infants and in infants with iodine excess , respectively ; however , no significant difference was found in these proportions ( P = 0.13 and P = 0.42 ) between the 4 groups . CONCLUSION Daily consumption of a multiple-micronutrient foodLET providing the RNI during infancy may be one strategy to improve iodine status
Despite the high risk of bias of many of the included studies , the results suggested that urinary iodine , thyroglobin , serum thyroxine , and thyroid-stimulating hormone are useful biomarkers of iodine status , at least in some groups .
BACKGROUND Biomarkers of iodine status are required to study iodine deficiency disorders in different parts of the world and to evaluate the effects of fortification strategies .
OBJECTIVE The objective was to assess the usefulness of biomarkers of iodine status in humans by systematic ally review ing intervention studies that altered iodine status .