This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .
Prospective Analysis of the Association of a Common Variant of FTO (rs9939609) with Adiposity in Children: Results of the IDEFICS Study
Objectives We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and  obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention . Population and Methods A cohort of 16224 children ( 2–9 years ) was recruited into a population -based survey ( T0 ) from eight European countries . A second survey ( T1 ) reassessed the children two years later . A r and om sample of 4405 children was extracted for genetic studies . 3168 children were re-examined two years later . Half of them underwent a lifestyle intervention program . The FTO rs9939609 was genotyped . Weight , height , waist circumference , triceps and subscapular skinfolds were measured at T0 and T1 . Results At T0 , the risk A allele of rs9939609 was significantly associated with higher values of body mass index ( BMI ) , waist circumference and skinfolds ( age , sex , and country-adjusted p-values : all p<0.001 ) and with a statistically significant increased risk of overweight/obesity . Over the two year follow-up , no interaction between genotype and intervention was observed . The A allele was associated to a significantly higher increase in all the anthropometric variables examined at T0 independently from the study group ( intervention versus control ) ( p-values : all p<0.002 , adjusted for age , sex , country , intervention/control study group , T0 values , and individual time interval between T0 and T1 ) . Over the two-year follow – up , 210 new cases of overweight/obesity occurred . A statistically significant higher incidence of overweight/obesity was associated to the A allele [ ORA = 1.95 , 95 % CI = ( 1.29 ; 2.97 ) ] . Conclusions We confirmed the association between the FTO rs9939609 and  body mass and overweight/obesity risk in European children . The main finding of the study is that the A allele carriers present higher increase of body mass and central adiposity over time and higher risk of developing overweight/obesity during growth , independently from intervention measures
This meta- analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers .
BACKGROUND Studies have suggested that the fat mass and obesity-associated ( FTO ) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions , but results are inconsistent .
OBJECTIVE We aim ed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions .