The results of this systematic review and meta‐ analysis suggest that probiotic and synbiotic supplementation may help to improve biomarkers of inflammation and oxidative stress in diabetic patients .
Abstract The role of gut microbiota in the management of diabetes has been shown .
Several current trials are investigating the effect of probiotics and prebiotics , which are widely used to modulate intestinal microbiota , on inflammatory factors and biomarkers of oxidative stress in diabetic patients ; however , their findings are controversial .
The aim of the current meta‐ analysis was to evaluate the effects of probiotic and synbiotic supplementation on levels of serum high‐sensitivity C‐reactive protein ( hs‐CRP ) and biomarkers of oxidative stress in diabetic patients .
The Impact of Probiotic Soy Milk Consumption on Oxidative Stress Among Type 2 Diabetic Kidney Disease Patients: A Randomized Controlled Clinical Trial.
OBJECTIVE Diabetic kidney disease ( DKD ) is one the most important complications of diabetes leading to end-stage renal disease . This study aim ed to determine the effects of probiotic soy milk consumption on oxidative stress biomarkers in type 2 DKD patients . METHODS Forty-eight patients were r and omly assigned to consume a diet containing 200 mL/day probiotic soy milk in the intervention group or soy milk in the control condition . As determinants of oxidative stress , malondialdehyde , 8-iso-prostagl and in F2α , oxidized glutathione , total antioxidant capacity , reduced glutathione ( GSH ) , glutathione peroxidase , and glutathione reductase were measured after 8 weeks of intervention according to the st and ard protocol . RESULTS Between groups analysis showed that DKD patients in the probiotic soy milk group had a higher mean value of GSH compared with those in the soy milk group . In the final adjusted model , this difference remained significant . Consistently , oxidized glutathione concentration was significantly reduced among patients in the probiotic soy milk group . Also , for activity levels of antioxidant enzymes including glutathione peroxidase and glutathione reductase , significant increased levels were observed between 2 intervention groups in the final adjusted model . However , no significant reduction of the serum 8-iso-prostagl and in F2α or malondialdehyde and no induction of TAC concentrations within and between the 2 groups in the crude and adjusted models were detected . CONCLUSION Overall , the results demonstrate that probiotic soy milk consumption could improve some oxidative stress factors among DKD patients . Further longitudinal studies with consideration of individual variation should be conducted
The results of this systematic review and meta‐ analysis suggest that probiotic and synbiotic supplementation may help to improve biomarkers of inflammation and oxidative stress in diabetic patients .
Abstract The role of gut microbiota in the management of diabetes has been shown .
Several current trials are investigating the effect of probiotics and prebiotics , which are widely used to modulate intestinal microbiota , on inflammatory factors and biomarkers of oxidative stress in diabetic patients ; however , their findings are controversial .
The aim of the current meta‐ analysis was to evaluate the effects of probiotic and synbiotic supplementation on levels of serum high‐sensitivity C‐reactive protein ( hs‐CRP ) and biomarkers of oxidative stress in diabetic patients .