In conclusion , bariatric surgery is associated with a reduction in specific adipokines including leptin , chemerin , and PAI-1 , whereas adiponectin is raised , adaptations that could be indicative of improved fat mass and function
Different adipokines secreted from adipose tissue , exert a range of physiological effects .
The aim of present systematic review and meta- analysis was to critically investigate the consequence of  bariatric surgery on circulating adipokines , that is , adiponectin , leptin , visfatin , resistin , plasminogen activator inhibitor , and chemerin .
Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding.
CONTEXT The insulin-mimetic adipocytokine visfatin has been linked to obesity . The influence of weight loss on plasma visfatin concentrations in obese subjects is unknown yet . OBJECTIVES In this study we investigated whether plasma visfatin concentrations are altered by weight loss in patients with obesity . DESIGN AND PATIENTS In a prospect i ve study , fasting plasma visfatin , leptin , and adiponectin concentrations were measured before and 6 months after gastric b and ing in 31 morbidly obese patients aged 40 + /- 11 yr with a body mass index ( BMI ) of 46 + /- 5 kg/m(2 ) . Fourteen healthy subjects aged 29 + /- 5 yr with a BMI less than 25 kg/m(2 ) served as controls . RESULTS Visfatin plasma concentrations were markedly elevated in obese subjects ( 0.037 + /- 0.008 microg/ml ) , compared with controls ( 0.001 + /- 0.000 microg/ml , P < 0.001 ) . Gastric b and ing  reduced BMI to 40 + /- 5 kg/m(2 ) , visfatin to 19.2 + /- 10.9 ng/ml , and leptin from 39.0 + /- 12.4 to 29.7 + /- 10.0 ng/ml and increased adiponectin from 0.015 + /- 0.007 to 0.017 + /- 0.007 microg/ml ( all P < 0.05 ) after 6 months . Insulin sensitivity as estimated by the homeostasis model assessment insulin resistance index was unchanged from 5.8 + /- 3.1 to 4.6 + /- 1.9 ( P = 0.13 ) , but individual changes of insulin resistance and visfatin were significantly associated ( P < 0.05 , r = -0.43 ) . CONCLUSIONS Elevated plasma visfatin concentrations in morbidly obese subjects are reduced after weight loss . This may be related to changes in insulin resistance over time
In conclusion , bariatric surgery is associated with a reduction in specific adipokines including leptin , chemerin , and PAI-1 , whereas adiponectin is raised , adaptations that could be indicative of improved fat mass and function
Different adipokines secreted from adipose tissue , exert a range of physiological effects .
The aim of present systematic review and meta- analysis was to critically investigate the consequence of  bariatric surgery on circulating adipokines , that is , adiponectin , leptin , visfatin , resistin , plasminogen activator inhibitor , and chemerin .