The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .
Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: a microarray analysis.
OBJECTIVE We previously found that lipoic acid ( LA ) improved high-fat diet (HFD)-induced dyslipidemia in rats . To eluci date the molecular mechanisms of that effect , we carried out experiments aim ed at analyzing biochemical parameters and gene expression profiles . METHODS C57BL/6 mice were r and omly assigned to one of three groups ( n = 8) . The control group consumed an ordinary diet ( 4.89 % fat , w/w ) . The other two experimental groups were fed with an HFD ( 21.45 % fat , w/w ) or an HFD plus 0.1 % LA . After 6 wk , plasma lipid level and antioxidant status were examined . To investigate the molecular mechanisms underlying the effects of LA on lipid metabolism and oxidative stress , we examined gene expression profiles in liver using the GeneChip microarray system . The differential expression of genes of interest identified by microarray technique was vali date d by real-time reverse transcription-polymerase chain reaction . RESULTS HFD result ed in significant alterations in lipid profiles and a depressed antioxidant defense system .  LA supplementation induced decreases in lipid peroxidation , plasma cholesterol , triacylglycerols , and low-density lipoprotein cholesterol and an increase in high-density lipoprotein in HFD-fed mice . DNA microarray analysis of the liver showed that LA ingestion upregulated the expression of genes related to beta-oxidation and free radical scavenger enzymes , whereas those involved in cholesterol synthesis were downregulated . CONCLUSION LA can prevent HFD-induced dyslipidemia by modulating lipid metabolism , especially by increasing beta-oxidation and decreasing cholesterol synthesis , and oxidative stress by increasing those of free radical scavenger enzyme gene expression
The overall  effect of ALA on serum triglyceride did not reveal any significant change , but in subgroup analysis based on health status ( diabetic vs. non‐diabetic ) , ALA decreased serum triglyceride levels in both diabetic and non‐diabetic groups compared with controls .
This meta‐ analysis revealed that ALA might favorably affect lipid profile especially LDL and TC .
ABSTRACT R and omized controlled trials ( RCTs ) have demonstrated that alpha lipoic acid ( ALA ) may change lipid profile , but their results are contradictory .
The aim of this study is to conduct a meta‐ analysis to assess the effects of ALA on lipid profile .