D and PA+D  interventions had larger effects on glucose reduction  than PA alone .
Lifestyle  interventions significantly improved FPG , HbA1c , FI , HOMA-IR , and bodyweight among adults without IGT or diabetes , and might reduce progression of hyperglycemia to type 2 diabetes mellitus
This study systematic ally assessed the effectiveness of lifestyle interventions on glycemic indicators among adults ( ⩾18years ) without IGT or diabetes .
One-year effectiveness of two hypocaloric diets with different protein/carbohydrate ratios in weight loss and insulin resistance.
BACKGROUND The maintenance of weight loss may be influenced by the distribution of macronutrients in the diet and insulin sensitivity . OBJECTIVE The objective of the study was to evaluate the longterm effect of two hypocaloric diets with different protein/carbohydrate ratios in overweight and obese individuals either with insulin resistance ( IR ) or without insulin resistance ( IS ) . DESIGN Prospect i ve , r and omized , clinical intervention study . Forty patients were classified as IR/IS after a 75 g oral glucose tolerance test and then r and omized to a diet with either 40 % carbohydrate/30 % protein/30 % fat ( diet A ) or 55 % carbohydrate/15 % protein/30 % fat ( diet B ) . RESULTS After one year of follow-up there was no difference in weight loss between diets A and B in each group , but the IS group maintained weight loss better than the IR group [ -5.7 ( 3.9 ) vs. -0.6 ( 4.1 ) ; P = 0.04 ] . No differences were found in either Homeostasis Model Assessment ( HOMA ) or other metabolic glucose parameters except lower insulin at 120 minutes with diet A [ 21.40 ( 8.30 ) vs. 71.40 ( 17.11 ) ; P = 0.02 ] . CONCLUSIONS The hypocaloric diets with different protein/carbohydrate ratios produced similar changes in weight . Insulin resistance may play a negative role in maintaining weight loss
D and PA+D  interventions had larger effects on glucose reduction  than PA alone .
Lifestyle  interventions significantly improved FPG , HbA1c , FI , HOMA-IR , and bodyweight among adults without IGT or diabetes , and might reduce progression of hyperglycemia to type 2 diabetes mellitus
This study systematic ally assessed the effectiveness of lifestyle interventions on glycemic indicators among adults ( ⩾18years ) without IGT or diabetes .