Resveratrol  significantly improves adiponectin but does not affect leptin concentrations .
Abstract The results of human clinical trials have revealed that the effects of resveratrol on adipokines are inconsistent .
The plasma leptin/adiponectin ratio predicts first cardiovascular event in men: a prospective nested case-control study.
OBJECTIVE The plasma leptin/adiponectin ( L/A ) ratio has been proposed as a preferential marker of atherosclerosis susceptibility compared to leptin and adiponectin alone . We determined the extent to which the L/A ratio predicts incident cardiovascular disease ( CVD ) taking account of clinical risk factors , microalbuminuria , the total cholesterol/HDL cholesterol ( TC/HDL-C ratio ) , triglycerides , high sensitive C-reactive protein ( hs-CRP ) and insulin sensitivity ( homeostasis model assessment ( HOMA(ir ) ) ) . METHODS A community-based prospect i ve nested case-control study was carried out in 103 non-diabetic men who developed a first cardiovascular event ( cases ) and 106 male control subjects ( no clinical ly manifest CVD and no lipid lowering drug use at baseline ; median follow-up of 3.0 and 10.5 years , respectively ) .  Plasma leptin , adiponectin , the leptin/adipnectin ( L/A ) ratio , as well as hs-CRP , HOMA(ir ) and the TC/HDL-C ratio were determined at baseline . RESULTS Plasma leptin levels and the L/A ratio were higher in cases vs. controls ( p=0.002 for both ) , but the difference in adiponectin was not significant ( p=0.10 ) . Age-adjusted incident CVD was associated with plasma leptin , adiponectin and the L/A ratio ( p=0.045 to p=0.001 ) . The relationships of incident CVD with plasma leptin ( p=0.19 ) and adiponectin ( p=0.073 ) lost statistical significance after additional adjustment for smoking , waist circumference , hypertension , microalbuminuria , the TC/HDL-C ratio , hs-CRP and HOMA(ir ) . In this fully adjusted analysis , the L/A ratio remained predictive of incident CVD ( hazard ratio : 1.40 ( 95 % CI 1.05 - 1.87 ) , p=0.024 ) . CONCLUSION This study suggests that the L/A ratio may be a preferential marker of a first cardiovascular event in men compared to plasma leptin and adiponectin levels alone
Resveratrol  significantly improves adiponectin but does not affect leptin concentrations .
Abstract The results of human clinical trials have revealed that the effects of resveratrol on adipokines are inconsistent .