A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?
Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition.
The authors investigated associations between serum  C-reactive protein ( CRP ) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospect i ve Investigation into Cancer and Nutrition ( 1992 - 2003 ) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center , age , sex , time of blood collection , fasting status , menopausal status , menstrual cycle phase , and hormone replacement therapy . In conditional logistic regression with adjustment for education , smoking , nutritional factors , body mass index , and waist circumference , CRP showed a significant nonlinear association with colon cancer risk but not rectal cancer risk . Multivariable-adjusted relative risks for CRP concentrations of > or = 3.0 mg/L versus < 1.0 mg/L were 1.36 ( 95 % confidence interval ( CI ) : 1.00 , 1.85 ; P-trend = 0.01 ) for colon cancer and 1.02 ( 95 % CI : 0.67 , 1.57 ; P-trend = 0.65 ) for rectal cancer . Colon cancer risk was significantly increased in men ( relative risk = 1.74 , 95 % CI : 1.11 , 2.73 ; P-trend = 0.01 ) but not in women ( relative risk = 1.06 , 95 % CI : 0.67 , 1.68 ; P-trend = 0.13 ) . Additional adjustment for C-peptide , glycated hemoglobin , and high density lipoprotein cholesterol did not attenuate these results . These data provide evidence that elevated CRP concentrations are related to a higher risk of colon cancer but not rectal cancer , predominantly among men and independently of obesity , insulin resistance , and dyslipidemia
A significant negative association was found between aerobic exercise intensity and fatigue reduction .
A peak effect was found for moderate-intensity aerobic exercise for improving walking endurance .
No dose-response relationship was found between exercise and markers of inflammation or exercise duration and outcomes .
Rates of adherence were typically high and few adverse events were reported .
Exercise is safe , reduces fatigue and increases endurance in cancer survivors .
QUESTION Is there a dose-response effect of exercise on inflammation , fatigue and activity in cancer survivors ?