The only eligible r and omised clinical trial did not demonstrate any consistent effects of NIRS plus a guideline on the assessed clinical outcomes .
The trial was , however , only powered to detect difference in cerebral oxygenation , not morbidities or mortality .
BACKGROUND Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants .
Cerebral near-infrared spectroscopy ( NIRS ) enables continuous estimation of cerebral oxygenation .
This diagnostic method coupled with appropriate interventions if NIRS is out of normal range ( that is cerebral oxygenation within the 55 % to 85 % range ) may offer benefits without causing more harms .
Therefore , NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of r and omised clinical trials and quasi-r and omised studies .
OBJECTIVES To evaluate the benefits and harms of interventions that attempt to alter cerebral oxygenation guided by cerebral NIRS monitoring in order to prevent cerebral injury , improve neurological outcome , and increase survival in preterm infants born more than 8 weeks preterm .
The relationship between cerebral oxygen saturation changes and postoperative cognitive dysfunction in elderly patients after coronary artery bypass graft surgery.
OBJECTIVE The aim of this study was to evaluate the predictive value of cerebral regional oxygen saturation ( rSO(2 ) ) in the occurrence of postoperative cognitive dysfunction ( POCD ) in elderly patients undergoing coronary artery bypass graft ( CABG ) surgery .  DESIGN A prospect i ve study . SETTING University hospital . PARTICIPANTS A total of 61 patients ( 84 % male ) with a mean age of 70.39 ± 4.69 on a waiting list for CABG surgery were enrolled in the study . INTERVENTION A  complete neurocognitive evaluation was performed 1 day before surgery as well as 4 to 7 days and 1 month after surgery . During surgery , rSO(2 ) was monitored continuously . MEASUREMENTS AND MAIN RESULTS POCD was defined as a reduction of 1 st and ard deviation on 2 or more neuropsychologic indices . Forty-six patients ( 80.7 % ) developed early POCD , and 23 ( 38.3 % ) showed late POCD . Patients whose rSO(2 ) decreased to less than 50 % during the surgery experienced more POCD 4 to 7 days after surgery ( p = 0.04 ) . In addition , a decrease of more than 30 % from the patient 's baseline rSO(2 ) was associated with POCD 1 month after surgery ( p = 0.03 ) . CONCLUSION Intraoperative cerebral oxygen desaturation is associated with early and late POCD in elderly patients . Cerebral oximetry is a promising tool in the prediction of subtle neuropsychologic deficits and further studies are needed
The only eligible r and omised clinical trial did not demonstrate any consistent effects of NIRS plus a guideline on the assessed clinical outcomes .
The trial was , however , only powered to detect difference in cerebral oxygenation , not morbidities or mortality .
BACKGROUND Cerebral injury and long-term neurodevelopmental impairment is common in extremely preterm infants .
Cerebral near-infrared spectroscopy ( NIRS ) enables continuous estimation of cerebral oxygenation .
This diagnostic method coupled with appropriate interventions if NIRS is out of normal range ( that is cerebral oxygenation within the 55 % to 85 % range ) may offer benefits without causing more harms .
Therefore , NIRS coupled with appropriate responses to abnormal findings on NIRS needs assessment in a systematic review of r and omised clinical trials and quasi-r and omised studies .
OBJECTIVES To evaluate the benefits and harms of interventions that attempt to alter cerebral oxygenation guided by cerebral NIRS monitoring in order to prevent cerebral injury , improve neurological outcome , and increase survival in preterm infants born more than 8 weeks preterm .