Fermented formula has the potential to reduce some , albeit not well-defined , digestive symptoms .
Current evidence does not support the use of fermented formula for preventing cow ’s milk allergy .
Conclusion : Limited available evidence suggests that the use of fermented infant formula , compared with the use of st and ard infant formula , does not offer clear additional benefits , although some benefit on gastrointestinal symptoms can not be excluded .
What is new• Limited evidence available suggests that the use of fermented infant formula , compared with the use of st and ard infant formula , does not offer clear additional benefits , although some benefit on gastrointestinal symptoms can not be excluded .
At the same time , no negative health effects have been documented
Abstract Fermented formulas , i.e. , those fermented with lactic acid-producing bacteria during the production process and not containing significant amounts of viable bacteria in the final product , are widely available in many countries .
Our aim was to systematic ally review published evidence related to the safety and health effects of the administration of fermented infant formulas compared with st and ard infant formulas .
Increased Poliovirus-Specific Intestinal Antibody Response Coincides with Promotion of Bifidobacterium longum-infantis and Bifidobacterium breve in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial
To determine whether the size of the intestinal bifidobacterial population can influence the immune response to  poliovirus vaccination in infants , we set up a r and omized , placebo-controlled trial . From birth to 4 mo , infants were given a fermented infant formula ( FIF ) or a st and ard formula ( placebo ) . Bifidobacteria were quantified monthly in infant stools . Antipoliovirus IgA response to Pentacoq ® was assessed before and 1 mo after the second vaccine injection . Thirty infants were r and omized , and 20 completed the study ( nine in the placebo group and 11 in the FIF group ) . Fecal bifidobacterial level was significantly higher with the FIF group at 4 mo of age ( p = 0.0498 ) . Furthermore , B. longum/B. infantis carriage was higher at 4 mo in the FIF group ( p = 0.0399 ) . Antipoliovirus IgA titers increased after Pentacoq ® challenge ( p < 0.001 ) , and the rise was significantly higher in the FIF group ( p < 0.02 ) . Antibody titers correlated with bifidobacteria , especially with B. longum/B. infantis and B. breve levels ( p < 0.002 ) . Infants who harbored B. longum/B. infantis also exhibited higher levels of antipoliovirus IgAs ( p < 0.002 ) . In conclusion , the present results indicate that antipoliovirus response can be triggered with a fermented formula that is able to favor intestinal bifidobacteria . Whether this effect on the immune system is achieved through the bifidogenic effect of the formula ( mainly through B. longum/B. infantis and B. breve stimulation ) or directly linked to compounds ( i.e. peptides ) produced by milk fermentation remains to be investigated
Fermented formula has the potential to reduce some , albeit not well-defined , digestive symptoms .
Current evidence does not support the use of fermented formula for preventing cow ’s milk allergy .
Conclusion : Limited available evidence suggests that the use of fermented infant formula , compared with the use of st and ard infant formula , does not offer clear additional benefits , although some benefit on gastrointestinal symptoms can not be excluded .
What is new• Limited evidence available suggests that the use of fermented infant formula , compared with the use of st and ard infant formula , does not offer clear additional benefits , although some benefit on gastrointestinal symptoms can not be excluded .
At the same time , no negative health effects have been documented
Abstract Fermented formulas , i.e. , those fermented with lactic acid-producing bacteria during the production process and not containing significant amounts of viable bacteria in the final product , are widely available in many countries .
Our aim was to systematic ally review published evidence related to the safety and health effects of the administration of fermented infant formulas compared with st and ard infant formulas .