Clinicians and patients should beware of possible decreases in the systemic bioavailability of conventional drugs when taken concomitantly with St John 's wort
OBJECTIVE To determine the method ological quality of clinical trials that examined possible interactions of St John 's wort with conventional drugs , and to examine the results of these trials .
Different effects of St John's Wort on the pharmacokinetics of simvastatin and pravastatin
St John 's Wort , a widely used herbal product , is an inducer of CYP3A4 and it decreases blood concentrations of CYP3A4 substrates . The effects of St John 's Wort on the pharmacokinetics of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors simvastatin  ( an inactive lactone pro‐drug ) and pravastatin were determined in this study
Clinicians and patients should beware of possible decreases in the systemic bioavailability of conventional drugs when taken concomitantly with St John 's wort
OBJECTIVE To determine the method ological quality of clinical trials that examined possible interactions of St John 's wort with conventional drugs , and to examine the results of these trials .