Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .
Effect of isolated vitamin D supplementation on the rate of falls and postural balance in postmenopausal women fallers: a randomized, double-blind, placebo-controlled trial
Objective : To evaluate the effect of isolated vitamin D supplementation ( VITD ) on the rate of falls and postural balance in postmenopausal women fallers . Methods : In this double-blind , placebo-controlled trial , 160 Brazilian younger postmenopausal women were r and omized into two groups : VITD group , vitamin D3 supplementation 1,000 IU/day/orally ( n = 80 ) and placebo group ( n = 80 ) . Women with amenorrhea at least 12 months , age 50 to 65 years , and a history of falls ( previous 12 months ) were included . Those with neurological or musculoskeletal disorders , vestibulopathies , drugs use that could affect balance and osteoporosis were excluded . The intervention time was 9 months . Postural balance was assessed by stabilometry ( computerized force platform ) and investigation on the occurrence/recurrence of falls was performed by interviews . The plasma concentration of 25-hydroxyvitamin D [ 25(OH)D ] was measured by high-performance liquid chromatography . Statistical analysis was achieved by intention-to-treat , using analysis of variance , Student 's t test , Tukey test , chi-square , and logistic regression . Results : After 9 months , mean values of 25(OH)D increased from 15.0 ± 7.5 ng/mL to 27.5 ± 10.4 ng/mL ( + 45.4 % ) in the VITD group , and decreased from 16.9 ± 6.7 ng/mL to 13.8 ± 6.0 ng/mL ( −18.5 % ) in the placebo group ( P < 0.001 ) . The occurrence of falls was higher in the placebo group ( + 46.3 % ) with an adjusted risk of 1.95 ( 95 % confidence interval [ CI ] 1.23 - 3.08 ) times more likely to fall and 2.80 ( 95 % CI 1.43 - 5.50 ) times higher for recurrent falls compared to the VITD group ( P < 0.001 ) . There was reduction in body sway by stabilometry , with lower amplitude of antero-posterior ( −35.5 % ) and latero-lateral ( −37.0 % ) oscillation , only in the VITD group ( P < 0.001 ) . Conclusions : In Brazilian postmenopausal women fallers  , isolated vitamin D supplementation for 9 months result ed in a lower incidence of falls and improvement in postural balance
Overall , intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose – response effect between intake dose and 25(OH)D concentration .
Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration .
Conclusions Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested
Background / Objectives Optimal doses of vitamin D ( VitD ) supplement in different population s are unclear .
We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [ 25(OH)D ] concentration , to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different population s .