Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .
Prophylactic antibiotics for elective laparoscopic cholecystectomy: are they necessary?
HYPOTHESIS Prophylactic antibiotic treatment in elective laparoscopic cholecystectomy does not lower the already low infection rate associated with this procedure . DESIGN AND SETTING Prospect i ve double-blind r and omized trial at a community-based training hospital . PATIENTS Four hundred fifty patients undergoing elective laparoscopic cholecystectomy were r and omized into 1 of 3 treatment arms : ( 1 ) preoperative cefotetan disodium , 1 g intravenously ; ( 2 ) preoperative cefazolin , 1 g intravenously ; and ( 3 ) intravenous placebo . There were no demographic differences between groups in age , smoking history , American Society of Anesthesiologists score , infection risk class , time of antibiotic administration prior to surgery , and type of skin preparation . INTERVENTIONS Laparoscopic cholecystectomy was attempted in all cases ; however , 10 patients required conversion to an open cholecystectomy and they were included in the statistical analysis . Preoperatively , all patients were r and omized in a blinded manner and received cefotetan , cefazolin , or placebo intravenously . RESULTS There were 10 postoperative infections . In the cefotetan group , there were 3 cases of superficial surgical site infections . In the cefazolin group , there were 2 superficial surgical site infections-1 pneumonia and 1 rhinosinusitis . In the placebo group , there were 2 superficial surgical site infections and 1 urinary tract infection . The overall infection rate in this series was 2.4 % . Follow-up was performed at routine postoperative visits and by telephone contact . Data were evaluated using the chi2 test and analysis of variance with Duncan post hoc test ( P<.05 ) . CONCLUSION Based on our data , use of prophylactic antibiotics does not decrease the rate of wound infections in elective laparoscopic cholecystectomy
Conclusions The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy
Background s/ Aims The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear .
This study aim ed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients .