The two articles that evaluated individuals with dyslipidemia showed improvement in lipid profile .
The mechanisms of action are still being studied .
ABSTRACT In this systematic review , we discuss the scientific evidence about the effect of dietary intake of seeds and sesame derivatives on lipid profile and blood pressure ( BP ) of hypertensive and dyslipidemic individuals .
Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients.
Several studies have shown that n-3 polyunsaturated fatty acids ( n-3 PUFA ) are able to lower blood pressure ( BP ) in humans , but large doses of fish oils have been often used . Moreover , most of the studies available in the literature were not able to evaluate the specific effects of n-3 PUFA because they employed fish oils which contain , together with n-3 PUFA , many other different components . The aim of this preliminary study was to evaluate if medium-term supplementation with a moderate dose of highly purified eicosapentaenoic acid ( EPA ) and docosahexaenoic acid ( DHA ) ethyl esters is able to reduce BP in mild hypertensive patients . Sixteen mild essential hypertensive ( diastolic BP : 95 - 104 mm Hg ) , non-diabetic , normolipidemic male out patients and 16 normotensive male controls were recruited to participate in the study . Both hypertensive and control subjects were r and omly assigned to receive either EPA and DHA ethyl esters ( 2.04 g EPA and 1.4 g DHA ) as active treatment or olive oil ( 4 g/day ) as a placebo for a period of 4 months . These subjects were followed up with 24-hour ambulatory BP monitoring and blood chemistry analyses at 2 and 4 months of treatment and 2 months after its discontinuation . The intake of n-3 PUFA was checked by red blood cell ( RBC ) phosphatidylcholine ( PC ) fatty acid composition . The effect of n-3 PUFA on BP in the active group was maximum after 2 months . Both systolic ( -6 mm Hg , p<0.05 ) and diastolic ( -5 mm Hg , p<0.05 ) BP significantly decreased during the n-3 PUFA ethyl ester supplementation . No further effect was observed at 4 months with a return to baseline values during the recovery period . These data indicate that 4 g/day of highly purified EPA + DHA ethyl esters are able to favorably affect BP in mild hypertensives
The two articles that evaluated individuals with dyslipidemia showed improvement in lipid profile .
The mechanisms of action are still being studied .
ABSTRACT In this systematic review , we discuss the scientific evidence about the effect of dietary intake of seeds and sesame derivatives on lipid profile and blood pressure ( BP ) of hypertensive and dyslipidemic individuals .