We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .
Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study
Background Omega–3 fatty acids prevent cardiovascular disease ( CVD ) events in patients with myocardial infa rct ion or heart failure . Benefits in patients without overt CVD have not been demonstrated , though most studies did not use treatment doses ( 3.36 g ) of omega-3 fatty acids .  Arterial stiffness measured by pulse wave velocity ( PWV ) predicts CVD events independent of st and ard risk factors . However , no therapy has been shown to reduce PWV in a blood pressure-independent manner . We assessed the effects of esterified omega–3 fatty acids on PWV and serum markers of inflammation among patients with hypertension . Design and methods We performed a prospect i ve , r and omized ; double-blinded pilot study of omega-3 fatty acids among 62 patients in an urban , safety net hospital . Patients received 3.36 g of omega–3 fatty acids vs. matched placebo daily for 3-months . The principal outcome measure was change in brachial-ankle PWV . Serum inflammatory markers associated with CVD risk were also assessed . Results The majority ( 71 % ) were of Latino ethnicity . After 3-months , mean change in arterial PWV among omega-3 and placebo groups was −97 cm/s vs. −33 cm/s respectively ( p = 0.36 for difference , after multivariate adjustment for baseline age , systolic blood pressure , and serum adiponectin ) . Non-significant reductions in lipoprotein-associated phospholipase A2 ( LpPLA2 ) mass and high sensitivity C-reactive protein ( hsCRP ) relative to placebo were also observed ( p = 0.08 , and 0.21 , respectively ) . Conclusion High-dose omega-3 fatty acids did not reduce arterial PWV or markers of inflammation among patients within a Latino-predominant population with hypertension . Clinical trial registration NCT00935766 , registered July 8 2009
We conclude that omega-3 fatty acids may be associated with lower inflammatory biomarkers among diabetic and cardiovascular patients .
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) patients .