There is very-low- quality evidence that clonidine has a small effect on oppositional behaviour and conduct problems in youth with ADHD , with and without ODD or CD .
There is moderate- quality evidence that guanfacine has a small-to-moderate effect on oppositional behaviour in youth with ADHD , with and without ODD .
There is high- quality evidence that atomoxetine has a small effect on oppositional behaviour in youth with ADHD , with and without ODD or CD .
Conclusions : Evidence indicates that psychostimulants , alpha-2 agonists , and atomoxetine can be beneficial for disruptive and aggressive behaviours in addition to core ADHD symptoms ; however , psychostimulants generally provide the most benefit
Objective : Children with attention-deficit hyperactivity disorder ( ADHD ) may have oppositional behaviour , conduct problems , and aggression .
These symptoms vary in severity , and may be related to a comorbid diagnosis of oppositional defiant disorder ( ODD ) or conduct disorder ( CD ) .
Critical evaluation of the efficacy of ADHD medications may guide the clinician regarding the usefulness of medications for these symptoms .
Effect of Lisdexamfetamine Dimesylate on Parent-Rated Measures in Children Aged 6 to 12 Years With Attention-Deficit/Hyperactivity Disorder: A Secondary Analysis
Objective : To evaluate the efficacy of lisdexamfetamine dimesylate ( LDX ) in school-aged children with attention-deficit/hyperactivity disorder ( ADHD ) , using the Conners ' Parent Rating Scale , Revised Short Version ( CPRS-R : S ) and its subscales . Methods : This was a secondary post hoc analysis of data from a placebo-controlled , double-blind , parallel-group , forced doseescalation trial . Boys and girls aged 6 to 12 years with a primary diagnosis of ADHD were r and omly assigned to LDX ( 30 , 50 , or 70 mg/d ) or placebo . Improvement on the CPRS-R : S and its subscales ( ADHD Index , hyperactivity , appositional , and cognition ) at 10 : 00 AM , 2 : 00 PM , and 6 : 00 PM was analyzed . Safety assessment s included the identification of adverse events and were conducted throughout the study . Results : Of the 290 patients r and omized , 285 were included in the intent-to-treat population . Parents noted significant improvements at all 3 assessment times on the CPRS-R : S total score and for the CPRS-R : S ADHD Index , hyperactivity , and cognition subscales , regardless of the subject baseline disease severity . For the CPRS-R : S appositional subscale , significant improvement was noted at 10 : 00 AM and 2 : 00 PM ( P < 0.01 ) , and overall , significant improvement occurred in subjects who were more severely ill at baseline . The tolerability of LDX was comparable to that of other stimulants . Conclusion : Once-daily treatment with LDX was associated with significant improvement in parent-rated assessment s of AD HO-related behavior throughout the day at approximately 10 : 00 AM , 2 : 00 PM , and 6 : 00 PM . Lisdexamfetamine dimesylate was effective and well tolerated in this study population of children aged 6 to 12 years with ADHD
There is very-low- quality evidence that clonidine has a small effect on oppositional behaviour and conduct problems in youth with ADHD , with and without ODD or CD .
There is moderate- quality evidence that guanfacine has a small-to-moderate effect on oppositional behaviour in youth with ADHD , with and without ODD .
There is high- quality evidence that atomoxetine has a small effect on oppositional behaviour in youth with ADHD , with and without ODD or CD .
Conclusions : Evidence indicates that psychostimulants , alpha-2 agonists , and atomoxetine can be beneficial for disruptive and aggressive behaviours in addition to core ADHD symptoms ; however , psychostimulants generally provide the most benefit
Objective : Children with attention-deficit hyperactivity disorder ( ADHD ) may have oppositional behaviour , conduct problems , and aggression .
These symptoms vary in severity , and may be related to a comorbid diagnosis of oppositional defiant disorder ( ODD ) or conduct disorder ( CD ) .
Critical evaluation of the efficacy of ADHD medications may guide the clinician regarding the usefulness of medications for these symptoms .