Conclusion This meta- analysis supports the potential use of microbial therapies in the treatment of NAFLD and sheds light on their potential mode of action .
Context Nonalcoholic fatty liver disease ( NAFLD ) is a highly prevalent and underdiagnosed comorbidity of many chronic diseases that is associated with altered intestinal bacterial communities .
This association has prompted research into alternative treatments aim ed at modulating intestinal microbiota .
Given the novelty of these treatments , scarce evidence regarding their effectiveness in clinical population s exists .
Objective This meta- analysis sought to systemically review and quantitatively synthesize evidence on prebiotic , probiotic , and synbiotic therapies for patients with NAFLD in r and omized controlled trials .
Effects of Synbiotic Food Consumption on Serum Minerals, Liver Enzymes, and Blood Pressure in Patients with Type 2 Diabetes: A Double-blind Randomized Cross-over Controlled Clinical Trial
Background : This research was to examine the effects of synbiotic intake on minerals , liver enzymes , and blood pressure in patients with type 2 diabetes ( T2D ) . Methods : This r and omized , cross-over clinical trial was performed among 62 diabetic patients . Persons were r and omly assigned to intake either a synbiotic ( n = 62 ) or a control food ( n = 62 ) for 6 weeks . A 3-week washout period was applied following which persons were crossed over to the alternate intervention arm for an additional 6 weeks . The synbiotic was consisted of Lactobacillus sporogenes ( 1 × 107 CFU ) , 0.04 g inulin ( HPX ) as prebiotic . Persons were asked to consume the synbiotic and control foods 27 g a day . Blood pressure was measured , and blood sample s were taken at baseline and after 6-week intervention to assess calcium , magnesium , iron , alkaline phosphatase , aspartate aminotransferase , alanine aminotransferase , and total bilirubin . Results : The consumption of a synbiotic food , compared to the control food , result ed in a significant rise of calcium ( 0.66 vs. −0.14 mg/dL , P = 0.03 ) and iron ( 5.06 vs. −9.98 mg/dL , P = 0.03 ) . The decrease of total bilirubin ( 0.08 vs. −0.04 mg/dL ; P = 0.009 ) was also seen in the synbiotic group compared with the control group . Conclusions : Overall , synbiotic in T2D patients had beneficial effects on calcium , iron , and total bilirubin concentrations
Conclusion This meta- analysis supports the potential use of microbial therapies in the treatment of NAFLD and sheds light on their potential mode of action .
Context Nonalcoholic fatty liver disease ( NAFLD ) is a highly prevalent and underdiagnosed comorbidity of many chronic diseases that is associated with altered intestinal bacterial communities .
This association has prompted research into alternative treatments aim ed at modulating intestinal microbiota .
Given the novelty of these treatments , scarce evidence regarding their effectiveness in clinical population s exists .
Objective This meta- analysis sought to systemically review and quantitatively synthesize evidence on prebiotic , probiotic , and synbiotic therapies for patients with NAFLD in r and omized controlled trials .