The pooled estimate from the studies suggested that the addition of testosterone to HT regimens improved sexual function scores for postmenopausal women .
A significant adverse effect was a decrease in high-density lipoprotein ( HDL ) cholesterol levels .
However , there is evidence that adding testosterone to HT has a beneficial effect on sexual function in postmenopausal women .
There was a reduction in HDL cholesterol associated with the addition of testosterone to the HT regimens .
It is , therefore , difficult to estimate the effect of testosterone on sexual function in association with any individual hormone treatment regimen
BACKGROUND : The value of adding testosterone to hormone therapy ( HT ) for the management of peri- and postmenopausal women is controversial and has not been systematic ally review ed .
OBJECTIVES : To determine the benefits and risks of testosterone therapy for peri- and postmenopausal women taking hormone therapy .
Effects of nandrolone decanoate on bone mass in established osteoporosis.
A double-blind , r and omized , placebo-controlled study was conducted in 46 postmenopausal women with established osteoporosis in order to assess the long-term effects of n and rolone decanoate on the bone mineral density ( BMD ) of the lumbar vertebrae and of the distal third of the radius and on the biochemical markers of bone turnover . The patients received intramuscular injections of placebo or 50 mg n and rolone decanoate every 3 weeks for 18 months . Thirty-two of the initial 46 patients completed 1 year of study and 25 completed the whole study period of 18 months . Overall , vertebral BMD increased by 2.9 % in the n and rolone decanoate group and fell by 2.3 % in the placebo group . Radial BMD showed a slight but transient improvement , with a subsequent return to basal levels in the n and rolone decanoate group , whereas there was a progressive decrease in the placebo group . Patients treated with n and rolone decanoate also complained less of bone pain . Urinary hydroxyproline decreased significantly in treated patients , whereas osteocalcin tended to increase , but the change was not significant . HDL cholesterol concentrations decreased only slightly and haemoglobin increased significantly in the n and rolone decanoate group . Two patients treated with n and rolone decanoate withdrew from the study because of hirsutism and hoarseness . The results indicate that n and rolone decanoate exerts positive effects on vertebral BMD and on bone pain in patients with established postmenopausal osteoporosis
The pooled estimate from the studies suggested that the addition of testosterone to HT regimens improved sexual function scores for postmenopausal women .
A significant adverse effect was a decrease in high-density lipoprotein ( HDL ) cholesterol levels .
However , there is evidence that adding testosterone to HT has a beneficial effect on sexual function in postmenopausal women .
There was a reduction in HDL cholesterol associated with the addition of testosterone to the HT regimens .
It is , therefore , difficult to estimate the effect of testosterone on sexual function in association with any individual hormone treatment regimen
BACKGROUND : The value of adding testosterone to hormone therapy ( HT ) for the management of peri- and postmenopausal women is controversial and has not been systematic ally review ed .
OBJECTIVES : To determine the benefits and risks of testosterone therapy for peri- and postmenopausal women taking hormone therapy .