AND RELEVANCE In a broad review of published literature , risk factors for SSI were characterized as describing reduced fitness , patient frailty , surgery duration , and complexity .
IMPORTANCE Surgical site infection ( SSI ) complicates 2 - 5 % of surgeries in the United States .
Severity of SSI ranges from superficial skin infection to life-threatening conditions such as severe sepsis , and SSIs are responsible for increased morbidity , mortality , and economic burden associated with surgery .
Staphylococcus aureus ( S. aureus ) is a commonly-isolated organism for SSI , and methicillin-resistant S. aureus SSI incidence is increasing globally .
OBJECTIVE The objective of this systematic review was to characterize risk factors for SSI within observational studies describing incidence of SSI in a real-world setting .
Risk factors for methicillin-resistant Staphylococcus aureus surgical site infection.
We prospect ively evaluated 46 possible risk factors for methicillin-resistant Staphylococcus aureus ( MRSA ) surgical site infection ( SSI ) among patients with MRSA carriage in a large intervention study . Of 6,130 study patients , 68 ( 1.1 % ) developed MRSA SSI , which occurred a median of 14 days after surgery . Risk factors associated with MRSA SSI were receipt of emergency surgery , presence of comorbid condition , receipt of immunosuppressive therapy , receipt of contaminated surgery , and a surgical duration longer than the 75th percentile . MRSA carriage on admission did not predict MRSA SSI
AND RELEVANCE In a broad review of published literature , risk factors for SSI were characterized as describing reduced fitness , patient frailty , surgery duration , and complexity .
IMPORTANCE Surgical site infection ( SSI ) complicates 2 - 5 % of surgeries in the United States .
Severity of SSI ranges from superficial skin infection to life-threatening conditions such as severe sepsis , and SSIs are responsible for increased morbidity , mortality , and economic burden associated with surgery .
Staphylococcus aureus ( S. aureus ) is a commonly-isolated organism for SSI , and methicillin-resistant S. aureus SSI incidence is increasing globally .
OBJECTIVE The objective of this systematic review was to characterize risk factors for SSI within observational studies describing incidence of SSI in a real-world setting .