During subgroup analysis , a more beneficial effect of magnesium supplementation was observed in diabetic subjects with hypomagnesaemia .
CONCLUSIONS Magnesium supplementation can produce a favourable effect on FPG , HDL , LDL , TG and SBP .
BACKGROUND Cardiovascular disorders remain the leading cause of death in type 2 diabetic patients .
In the present study , a systematic review and a meta- analysis of r and omised controlled trials ( RCTs ) were conducted aim ing to evaluate the effect of magnesium supplementation on  type 2 diabetes ( T2D ) associated cardiovascular risk factors in both diabetic and nondiabetic individuals .
The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial
To test the blood pressure (BP)-lowering effect of oral magnesium supplementation ( that is , magnesium chloride ( MgCl2 ) solution ) in diabetic hypertensive adults with hypomagnesaemia not on diuretic treatment but receiving concurrent captopril  , we conducted a double-blind , placebo-controlled trial . Eighty-two subjects between 40 and 75 years of age were r and omly enrolled . Over 4 months , subjects in the intervention group received 2.5 g of MgCl2 ( 50 ml of a solution containing 50 g of MgCl2 per 1000 ml of solution ) equivalent to 450 mg of elemental magnesium , and control subjects inert placebo . The primary trial end point was a reduction in systolic ( SBP ) and diastolic ( DBP ) blood pressure . Complete follow-up was achieved for 79 of the 82 r and omized subjects . SBP ( −20.4±15.9 versus −4.7 ± 12.7 mm Hg , P=0.03 ) and DBP ( −8.7±16.3 versus −1.2±12.6 mm Hg , P=0.02 ) showed significant decreases , and high-density lipoprotein-cholesterol ( 0.1±0.6 versus −0.1±0.7 mmol l−1 , P=0.04 ) a significant increase in the magnesium group compared to the placebo group . The adjusted odds ratio between serum magnesium and BP was 2.8 ( 95%CI : 1.4–6.9 ) . Oral magnesium supplementation with MgCl2 significantly reduces SBP and DBP in diabetic hypertensive adults with hypomagnesaemia
During subgroup analysis , a more beneficial effect of magnesium supplementation was observed in diabetic subjects with hypomagnesaemia .
CONCLUSIONS Magnesium supplementation can produce a favourable effect on FPG , HDL , LDL , TG and SBP .
BACKGROUND Cardiovascular disorders remain the leading cause of death in type 2 diabetic patients .
In the present study , a systematic review and a meta- analysis of r and omised controlled trials ( RCTs ) were conducted aim ing to evaluate the effect of magnesium supplementation on  type 2 diabetes ( T2D ) associated cardiovascular risk factors in both diabetic and nondiabetic individuals .