Overall , the current meta- analysis demonstrated that resveratrol intake significantly reduced weight , BMI , WC and fat mass , and significantly increased lean mass , but did not affect leptin and adiponectin levels
Abstract This systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to summarize the effect of resveratrol intake on weight loss .
The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans
ABSTRACT Dietary polyphenols have beneficial effects on adipose tissue mass and function in rodents , but human studies are scarce . In a r and omized , placebo-controlled study , 25 ( 10 women ) overweight and obese humans received a combination of the polyphenols epigallocatechin-gallate and resveratrol ( 282 mg/d , 80 mg/d , respectively , EGCG+RES , n = 11 ) or placebo ( PLA , n = 14 ) supplementation for 12 weeks . Abdominal subcutaneous adipose tissue ( SAT ) biopsies were collected for assessment of adipocyte morphology and micro-array analysis . EGCG+RES had no effects on adipocyte size and distribution compared with PLA . However , we identified pathways contributing to adipogenesis , cell cycle and apoptosis were significantly downregulated by EGCG+RES versus PLA . Furthermore , EGCG+RES significantly decreased expression of pathways related to energy metabolism , oxidative stress , inflammation , and immune defense as compared with PLA . In conclusion , the SAT gene expression profile indicates a reduced cell turnover after 12-week EGCG+RES in overweight-obese subjects . It remains to be eluci date d whether these alterations translate into long-term metabolic effects
Overall , the current meta- analysis demonstrated that resveratrol intake significantly reduced weight , BMI , WC and fat mass , and significantly increased lean mass , but did not affect leptin and adiponectin levels
Abstract This systematic review and meta- analysis of r and omized controlled trials ( RCTs ) was conducted to summarize the effect of resveratrol intake on weight loss .