However , resveratrol was not significantly effective on total cholesterol in both sample s. The results of subgroup analysis of human studies showed that resveratrol has significant effect on metabolic parameters ( glucose level and WC ) at the dosage of > 500 mg and with long-term interventions ≥ 10 weeks .
Administration of resveratrol can meaningfully reduce the BW , WC , TGs , and glucose level , also it can increase HDL , but not total cholesterol
This meta- analysis was carried out to determine the association between the resveratrol intake with metabolic parameters in metabolic syndrome patients .
Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure.
BACKGROUND AND AIMS Flow-mediated dilatation of the brachial artery ( FMD ) is a biomarker of endothelial function and cardiovascular health . Impaired FMD is associated with several cardiovascular risk factors including hypertension and obesity . Various food ingredients such as polyphenols have been shown to improve FMD . We investigated whether consuming resveratrol , a polyphenol found in red wine , can enhance FMD acutely and whether there is a dose-response relationship for this effect . METHODS AND RESULTS 19 overweight/obese ( BMI 25 - 35 kg m(-2 ) ) men or post-menopausal women with untreated borderline hypertension ( systolic BP : 130 - 160 mmHg or diastolic BP : 85 - 100 mmHg ) consumed three doses of resveratrol ( resVida ™ 30 , 90 and 270 mg ) and a placebo at weekly intervals in a double-blind , r and omized crossover comparison . One hour after consumption of the supplement , plasma resveratrol and FMD were measured . Data were analyzed by linear regression versus log(10 ) dose of resveratrol . 14 men and 5 women ( age 55 ± 2 years , BMI 28.7 ± 0.5 kg m(-2 ) , BP 141 ± 2/89 ± 1 mmHg ) completed this study . There was a significant dose effect of resveratrol  on plasma resveratrol concentration ( P < 0.001 ) and on FMD ( P < 0.01 ) , which increased from 4.1 ± 0.8 % ( placebo ) to 7.7 ± 1.5 % after 270 mg resveratrol . FMD was also linearly related to log(10 ) plasma resveratrol concentration ( P < 0.01 ) . CONCLUSION Acute resveratrol consumption increased plasma resveratrol concentrations and FMD in a dose-related manner . This effect may contribute to the purported cardiovascular health benefits of grapes and red wine
However , resveratrol was not significantly effective on total cholesterol in both sample s. The results of subgroup analysis of human studies showed that resveratrol has significant effect on metabolic parameters ( glucose level and WC ) at the dosage of > 500 mg and with long-term interventions ≥ 10 weeks .
Administration of resveratrol can meaningfully reduce the BW , WC , TGs , and glucose level , also it can increase HDL , but not total cholesterol
This meta- analysis was carried out to determine the association between the resveratrol intake with metabolic parameters in metabolic syndrome patients .