In regards to surgery it is recommended to perform total omentectomy since subclinic metastasis have been documented in 10 - 30 % of all cases , and systematic limphadenectomy , necessary to be able to obtain an adequate surgical staging .
Minimal invasion surgery is not a recommended procedure for the treatment of advanced ovarian cancer .
Radiotherapy can be used to palliate symptoms .
In the present , there is not a st and ardized screening method .
Diagnosis in early stages means a better survival .
Radiotherapy can be indicated to palliate symptoms
INTRODUCTION Ovarian cancer ( OC ) is the third most common gynecologic malignancy worldwide .
Most of cases it is of epithelial origin .
At the present time there is not a st and ardized screening method , which makes difficult the early diagnosis .
The 5-year survival is 90 % for early stages , however most cases present at advanced stages , which have a 5-year survival of only 5 - 20 % .
GICOM collaborative group , under the auspice of different institutions , have made the following consensus in order to make recommendations for the diagnosis and management regarding to this neoplasia .
Until now , laparoscopy for diagnostic-staging surgery is not well known as a recommended method .
In advanced stages , primary cytoreduction is recommended as initial treatment .
Phase II trial of gemcitabine in refractory germ cell tumors.
PURPOSE This phase II study was design ed to determine the toxicity and activity of single-agent gemcitabine in heavily pretreated patients with germ cell tumors . PATIENTS AND METHODS From March 1996 through November 1997 , 21 patients were enrolled onto a phase II study of  gemcitabine 1,200 mg/m2 , given on days 1 , 8 , and 15 every 4 weeks . One patient was unassessable because he never received any gemcitabine .  Thirteen of 20 patients had received three prior regimens , and 13 patients were platinum refractory ( progression during or within 4 weeks of platinum treatment ) . There were five extragonadal cases and two patients with late relapse ( relapse beyond 2 years ) . RESULTS Gemcitabine was well tolerated . Only one patient had grade 3 or 4 nonhematologic toxicity ( grade 3 nausea ) . Six of 20 patients had grade 3 leukopenia . There were no episodes of granulocytopenic fever , and no patient required platelet transfusion . Three ( 15 % ) of 20 patients achieved an objective response , including one complete remission . Three additional patients had a minor radiographic or serologic response . CONCLUSION Gemcitabine had definite activity in this heavily pretreated germ cell tumor patient population
In regards to surgery it is recommended to perform total omentectomy since subclinic metastasis have been documented in 10 - 30 % of all cases , and systematic limphadenectomy , necessary to be able to obtain an adequate surgical staging .
Minimal invasion surgery is not a recommended procedure for the treatment of advanced ovarian cancer .
Radiotherapy can be used to palliate symptoms .
In the present , there is not a st and ardized screening method .
Diagnosis in early stages means a better survival .
Radiotherapy can be indicated to palliate symptoms
INTRODUCTION Ovarian cancer ( OC ) is the third most common gynecologic malignancy worldwide .
Most of cases it is of epithelial origin .
At the present time there is not a st and ardized screening method , which makes difficult the early diagnosis .
The 5-year survival is 90 % for early stages , however most cases present at advanced stages , which have a 5-year survival of only 5 - 20 % .
GICOM collaborative group , under the auspice of different institutions , have made the following consensus in order to make recommendations for the diagnosis and management regarding to this neoplasia .
Until now , laparoscopy for diagnostic-staging surgery is not well known as a recommended method .
In advanced stages , primary cytoreduction is recommended as initial treatment .