However , it can significantly decrease postintervention and reduction data of FPG , FI , HbA1c , and HOMA-IR .
Heterogeneity was eliminated by subgroup analysis according to baseline BMI .
There was no significant difference in the amelioration of QUICKI between the ITC and control groups .
However , the difference was statistically significant and the heterogeneity was eliminated after subgroup analysis according to intakes of ITC .
Conclusion Supplementation of ITC can ameliorate IR in T2DM , especially in obese T2DM patients , but the effects are controversial in obese patients
Background Insulin resistance ( IR ) is a physiological condition related to type 2 diabetes mellitus ( T2DM ) and obesity , which is associated with high blood insulin and glucose .
Inulin-type carbohydrate ( ITC ) is a kind of fermentable fructan that can reduce glucose and ameliorate IR in an animal model , but the effect in clinical trials is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of ITC supplementation in ameliorating IR in T2DM and obese patients .
Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail
Purpose : The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly . Currently , the complications of diabetes are the major health concern . The aim of this study was to investigate the effect of high performance ( HP ) inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes . Methods : In the present clinical trial conducted for a duration of 6 weeks , 46 volunteers diabetic patients referring to diabetes clinic in Tabriz , Iran , were r and omly assigned into intervention ( n= 23 , consuming 10 gr/d HP inulin ) and control groups ( n= 23 , consuming 10 gr/ d starch ) . We assessed glycemic and anthropometric indices , blood lipids and plasmatic level of miR-375 as well as KLF5 mRNA expression before and after the intervention . Results : Findings indicated that inulin supplementation significantly decreased fasting plasma glucose ( FPG ) in comparison to the placebo group ( P<0.001 ) . Also Intra-group and between group results showed that inulin supplementation result ed in significant decrease in KLF5 mRNA expression in peripheral blood mononuclear cells ( P BMC s ) ( Fold change : 0.61± 0.11 ; P-value= 0.001 ) and significant increase in plasmatic level of miR-375 ( Fold change : 3.75± 0.70 ; P-value=0.004 ) . Conclusion : Considering the improvements of FPG level in diabetic patients , it seems that HP inulin supplementation may be beneficial in controlling diabetes via the expression of some genes . However , further studies are needed to achieve concise conclusions
However , it can significantly decrease postintervention and reduction data of FPG , FI , HbA1c , and HOMA-IR .
Heterogeneity was eliminated by subgroup analysis according to baseline BMI .
There was no significant difference in the amelioration of QUICKI between the ITC and control groups .
However , the difference was statistically significant and the heterogeneity was eliminated after subgroup analysis according to intakes of ITC .
Conclusion Supplementation of ITC can ameliorate IR in T2DM , especially in obese T2DM patients , but the effects are controversial in obese patients
Background Insulin resistance ( IR ) is a physiological condition related to type 2 diabetes mellitus ( T2DM ) and obesity , which is associated with high blood insulin and glucose .
Inulin-type carbohydrate ( ITC ) is a kind of fermentable fructan that can reduce glucose and ameliorate IR in an animal model , but the effect in clinical trials is controversial .
Objective The authors conducted a systematic literature review to evaluate the effect of ITC supplementation in ameliorating IR in T2DM and obese patients .