Based on the existing information , it is not possible to establish the role of antioxidants and vitamin D supplementation in atopic disease development .
There is no evidence of major effects of prenatal use of folic acid on asthma or allergies .
The association of some nutritional interventions with less atopic sensitization seems rather speculative even if such an effect has not been found for some other foods .
The findings indicate rather a balanced and diverse diet without restrictions than a special dietary protocol .
Farming-related exposures may protect against the development of atopic disorders in children .
Long-chain polyunsaturated fatty acids and probiotics seem to be promising c and i date s for allergy prevention .
The paper refers to the recently published empirical data and systematic review s on the impact of diets , foods , nutrients and bioactive substance exposures in pregnancy and in early infancy , on the development of atopic disorders .
Prenatal Vitamin D Supplementation and Child Respiratory Health: A Randomised Controlled Trial
Background Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing .  We examined the effect of prenatal vitamin D on childhood wheezing  in an interventional study . Methods We r and omised 180 pregnant women at 27 weeks gestation to either  no vitamin D , 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol  , in an ethnically stratified , r and omised controlled trial . Supplementation improved but did not optimise vitamin D status . Research ers blind to allocation assessed offspring at 3 years . Primary outcome was any history of wheeze assessed by vali date d question naire . Secondary outcomes included atopy , respiratory infection , impulse oscillometry and exhaled nitric oxide . Primary analyses used logistic and linear regression . Results We evaluated 158 of 180 ( 88 % ) offspring at age 3 years for the primary outcome . Atopy was assessed by skin test for 95 children ( 53 % ) , serum IgE for 86 ( 48 % ) , exhaled nitric oxide for 62 ( 34 % ) and impulse oscillometry of acceptable quality for 51 ( 28 % ) . We found no difference between supplemented and control groups in risk of wheeze  [ no vitamin D : 14/50 ( 28 % ) ; any vitamin D : 26/108 ( 24 % ) ( risk ratio 0.86 ; 95 % confidence interval 0.49 , 1.50 ; P = 0.69 ) ] . There was no significant difference in atopy , eczema risk , lung function or exhaled nitric oxide between supplemented groups and controls . Conclusion Prenatal vitamin D supplementation in late pregnancy that had a modest effect on cord blood vitamin D level , was not associated with decreased wheezing in offspring at age three years . Trial Registration Controlled-Trials.com IS RCT
Based on the existing information , it is not possible to establish the role of antioxidants and vitamin D supplementation in atopic disease development .
There is no evidence of major effects of prenatal use of folic acid on asthma or allergies .
The association of some nutritional interventions with less atopic sensitization seems rather speculative even if such an effect has not been found for some other foods .
The findings indicate rather a balanced and diverse diet without restrictions than a special dietary protocol .
Farming-related exposures may protect against the development of atopic disorders in children .
Long-chain polyunsaturated fatty acids and probiotics seem to be promising c and i date s for allergy prevention .
The paper refers to the recently published empirical data and systematic review s on the impact of diets , foods , nutrients and bioactive substance exposures in pregnancy and in early infancy , on the development of atopic disorders .