The present study revealed that supplementation with ALA slightly but significantly decreased body weight and BMI .
Safe dosage for ALA is up to 1200 mg/day .
However , it seems that ALA can not be cost-effective .
BACKGROUND & AIMS Previous studies have supported positive roles of antioxidant supplements on  weight-loss .
One antioxidant supplement is Alpha-lipoic acid .
However , recommending ALA as an anti-obesity supplement remains controversial .
Accordingly , the purpose of the present study was to perform a meta- analysis on the effects of ALA supplement on anthropometric indices  among adult subjects .
Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients.
OBJECTIVE To examine the effects of alpha-lipoic acid ( ALA ) treatment over a period of 2 months on fasting blood glucose ( FBG ) , insulin resistance ( IR ) , and glutathione peroxidase ( GH-Px ) activity in type 2 diabetes ( T2DM ) patients . METHODS This study took place in Motahari Clinic , Shiraz , Iran , which is affiliated to Shiraz University of Medical Sciences from May to October 2006 . Type 2 DM patients ( n=57 ) were divided into 2 groups to receive either ALA ( 300 mg daily ) or placebo by systematic r and omization , and were followed-up for 8 weeks . After an overnight fasting and 2 hours after breakfast , patients ' blood sample s were drawn and tested for FBG , 2 hours  PPG , serum insulin level , and GH-Px activity .  RESULTS The result of the study showed a significant decrease in FBG and PPG levels , IR-Homeostasis Model Assessment ( IR-HOMA index ) and GH-Px level in the ALA group . The comparison of differences between FBG and IR at the beginning and at the end of study in the ALA treated group and the placebo group were also significant . CONCLUSION This study supports the use of ALA as an antioxidant in the care of diabetic patients
The present study revealed that supplementation with ALA slightly but significantly decreased body weight and BMI .
Safe dosage for ALA is up to 1200 mg/day .
However , it seems that ALA can not be cost-effective .
BACKGROUND & AIMS Previous studies have supported positive roles of antioxidant supplements on  weight-loss .
One antioxidant supplement is Alpha-lipoic acid .
However , recommending ALA as an anti-obesity supplement remains controversial .
Accordingly , the purpose of the present study was to perform a meta- analysis on the effects of ALA supplement on anthropometric indices  among adult subjects .