Antibiotics covering aerobic and aerobic bacteria should be delivered orally and intravenously prior to colorectal surgery.  Antibiotics delivered within this framework will reduce the risk of postoperative SWI by at least 75%.  Further research is required to establish the optimal timing and duration of dosing, and frequency of longer-term adverse effects such as Clostridium difficile pseudomembranous colitis.
[Perioperative antibiotic prevention in colon and rectum surgery. A randomized study on the value of single dose prevention].
In a prospective randomized trial clinical results of one-shot-prophylaxis with Tinidazole (Group I, n = 50) versus 9 doses of Metronidazole (Group II, n = 50) as perioperative short-time-prophylaxis were compared. The rate of postoperative wound infections was not significantly different in the groups (p = 0,09). (1/50 in Group I = 2%, 5/50 in Group II = 10%). Postoperative complications clearly occurred less frequently in the first group than in the second one (12% versus 34%, p0,01). Our investigation indicates that prophylactic treatment with Tinidazole as a preoperative high and single dose is important for preventing postoperative infection in patients undergoing bowel surgery.