No results are conclusive and all are based on small, short, studies. It would be understandable, however, if clinicians were cautious in prescribing doses in excess of 7.5 mg/day of haloperidol to a person with uncomplicated acute schizophrenia, and if people with schizophrenia were equally reticent to take greater doses. Further research is needed regarding the efficacy and tolerability of the >1.5-3.0 mg/day dose range.
Further evidence of a dose-response threshold for haloperidol in psychosis.
The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response.
                During a 2-week, double-blind, randomized fixed-dose study, 24 psychotic patients were given 4, 10, or 40 mg/day of haloperidol.
                No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected.
                Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.