Antibiotics covering aerobic and aerobic bacteria should be delivered orally and intravenously prior to colorectal surgery.  Antibiotics delivered within this framework will reduce the risk of postoperative SWI by at least 75%.  Further research is required to establish the optimal timing and duration of dosing, and frequency of longer-term adverse effects such as Clostridium difficile pseudomembranous colitis.
Parenteral single dose ceftriaxone with tinidatsole versus aminoglycoside with tinidatsole in colorectal surgery: a prospective single-blind randomized multicentre study.
A single dose preoperative antibiotic prophylaxis of ceftriaxone 2 g and tinidatsole 500 mg was compared with netilmycin (150 mg) or tobramycin (80 mg) in patients undergoing colorectal surgery by a prospective randomised single-blind trial. There were 628 patients from seven Finnish hospitals. The wound infection rate of 3% in the ceftriaxone group was significantly lower than 12% of the aminoglycoside group. Wound infection was related to the amount of perioperative blood loss, duration of the operation, type of operation and drainage in the aminoglycoside group. In the ceftriaxone group, wound infection was related to the patient's weight only.