Methenamine hippurate may be effective for preventing UTI in patients without renal tract abnormalities, particularly when used for short-term prophylaxis. It does not appear to work in patients with neuropathic bladder or in patients who have renal tract abnormalities. The rate of adverse events was low, but poorly described.
There is a need for further large well-conducted RCTs to clarify this question, particularly for longer term use for people without neuropathic bladder.
[Preventive Hiprex in urinary tract operations].