Antibiotics covering aerobic and aerobic bacteria should be delivered orally and intravenously prior to colorectal surgery.  Antibiotics delivered within this framework will reduce the risk of postoperative SWI by at least 75%.  Further research is required to establish the optimal timing and duration of dosing, and frequency of longer-term adverse effects such as Clostridium difficile pseudomembranous colitis.
Ceftriaxone as prophylaxis for elective abdominal and colorectal surgery. Studies in the Departments of Surgery at the Universities of the Orange Free State, Natal and Pretoria.