Current evidence regarding the effectiveness of anticonvulsants in patients with tinnitus has significant risk of bias. There is no evidence from studies performed so far to show that anticonvulsants have a large positive effect in the treatment of tinnitus but a small effect (of doubtful clinical significance) has been demonstrated.
Relief of idiopathic subjective tinnitus: is gabapentin effective?
To assess the therapeutic benefit of gabapentin (Neurontin) for subjective idiopathic troublesome tinnitus.
                An 8-week, double-blind, randomized clinical trial.
                Academic otolaryngology clinic in St Louis, Mo.
                One hundred thirty-five subjects with severe idiopathic subjective tinnitus of 6 months' duration or longer.
                Gabapentin, at a maintenance dosage of 900 to 3600 mg/d for 8 weeks, or lactose placebo.
                Change in the Tinnitus Handicap Inventory score from baseline to the study end point.
                The overall change in the Tinnitus Handicap Inventory score for the entire cohort from baseline to week 8 was 11.2; the change among the 59 subjects randomized to the gabapentin arm was 11.3 and the change among the 56 subjects in the placebo arm was 11.0. The difference was 0.03 (95% confidence interval, -5.5 to 6.2; P = .91).
                Gabapentin is no more effective than placebo for the relief of idiopathic subjective tinnitus.
                clinicaltrials.gov Identifier: NCT00317850.