Sentence: The standard chemotherapy for localized ESFT now comprises vincristine , actinomycin D , cyclophosphamide and doxorubicin ( VACD ) in Europe or vincristine , doxorubicin , cyclophosphamide , ifosfamide and etoposide ( VDC-IE ) in North America .
Drug combination annotation:
[{'class': 'COMB', 'spans': ['vincristine', 'actinomycin D', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5, 6, 7, 8], 'is_context_needed': True}]