Sentence: In the phase I trial , 19 patients received bolus doxorubicin ( 50 mg/m2 ) followed after a 16-hour interval by paclitaxel ( given at dose levels ranging from 130 to 250 mg/m2 ) by 3-hour infusion every 3 weeks , for a maximum of eight cycles .
Drug combination annotation:
[{'class': 'POS', 'spans': ['doxorubicin', 'paclitaxel'], 'is_context_needed': True}]