Sentence: Forty-seven patients with previously untreated metastatic or unresectable colorectal adenocarcinoma received capecitabine 1000 mg/m2 twice daily on days 2 - 15 and intravenous irinotecan 100 mg/m2 on days 1 and 8 , every 21 days .
Drug combination annotation:
[{'class': 'POS', 'spans': ['capecitabine', 'irinotecan'], 'is_context_needed': True}]