Sentence: In a previous trial , we found that adding the antiandrogen flutamide to leuprolide acetate ( a synthetic gonadotropin-releasing hormone that results in medical ablation of testicular function ) significantly improved survival as compared with that achieved with placebo plus leuprolide acetate .
Drug combination annotation:
[{'class': 'POS', 'spans': ['flutamide', 'leuprolide acetate'], 'is_context_needed': False}]