Sentence: We found that melatonin in combination with all-trans retinoic acid and somatostatin potentiated the effects of melatonin alone on MCF-7 cell viability and growth inhibition ; this phenomenon was associated with altered conductance through Ca²⁺ and voltage-activated K⁺ ( BK ) channels , and with substantial impairments of Notch-1 and epidermal growth factor (EGF)-mediated signaling .
Drug combination annotation:
[{'class': 'POS', 'spans': ['melatonin', 'all-trans retinoic acid', 'somatostatin'], 'is_context_needed': True}]