Sentence: Reflecting the role of STAT3 in inducing localized immune suppression , using both atovaquone and pyrimethamine resulted in the modulation of immunoregulatory genes predicted to enhance an immune response , including upregulation of ICOSLG ( Inducible T-Cell Costimulator Ligand or B7H2 ) .
Drug combination annotation:
[{'class': 'POS', 'spans': ['atovaquone', 'pyrimethamine'], 'is_context_needed': False}]