Sentence: In some recently updated clinical guidelines , the fully humanized monoclonal antibody panitumumab , combined with irinotecan , has been recommended as an optional third-line chemotherapy for KRAS wild-type metastatic colorectal cancer ( mCRC ) .
Drug combination annotation:
[{'class': 'POS', 'spans': ['panitumumab', 'irinotecan'], 'is_context_needed': False}]