Sentence: Two Phase 1 studies assessed effects of ABT-450 ( 150 mg coadministered with ritonavir 100 mg once daily ) , ombitasvir ( 25 mg once daily ) , and dasabuvir ( 400 mg twice daily ) on the pharmacokinetics , safety , and tolerability of a single dose of cyclosporine ( 30 mg ) or tacrolimus ( 2 mg ) in healthy volunteers ( N = 12 per study ) .
Drug combination annotation:
[{'class': 'POS', 'spans': ['ABT-450', 'ritonavir', 'ombitasvir', 'dasabuvir', 'cyclosporine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2, 3, 5], 'is_context_needed': True}]