Sentence: A phase 1b , dose escalation study was performed to assess maximum tolerated dose , safety/toxicity , clinical efficacy and explored pharmacodynamic biomarkers of response to entinostat combined with lapatinib with or without trastuzumab .
Drug combination annotation:
[{'class': 'POS', 'spans': ['entinostat', 'lapatinib', 'trastuzumab'], 'is_context_needed': True}]