Sentence: We proved experimentally the use of ECEEM for multiplex determination of kinetic parameters describing weak ( 3 mM > K(d ) > 80 μM ) and fast ( 0.25 s ≥ τ ≥ 0.9 ms ) noncovalent interactions between four small molecule drugs ( ibuprofen , S-flurbiprofen , salicylic acid and phenylbutazone ) and α- and β-cyclodextrins .
Drug combination annotation:
[{'class': 'COMB', 'spans': ['ibuprofen', 'β-cyclodextrins'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 4], 'is_context_needed': True}, {'class': 'COMB', 'spans': [3, 4], 'is_context_needed': True}]