Sentence: Cyclophosphamide , doxorubicin , vincristine , and prednisone ( CHOP ) or CHOP-like regimens have been the backbone while more intensive regimens such as cyclophosphamide , vincristine , doxorubicin , high-dose methotrexate/ifosfamide , etoposide , high-dose cytarabine ( CODOX-M/IVAC ) , or dose-adjusted etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ( DA-EPOCH ) are possible options .
Drug combination annotation:
[{'class': 'COMB', 'spans': ['Cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5, 6, 7, 8, 14], 'is_context_needed': True}, {'class': 'COMB', 'spans': [9, 10, 11, 12, 13], 'is_context_needed': True}]