Sentence: Further analyses demonstrated that gemcitabine could significantly interfere with the cytotoxic effects of paclitaxel on both mitotic arrest and apoptotic cell death unless paclitaxel is administered before gemcitabine .
Drug combination annotation:
[{'class': 'POS', 'spans': ['paclitaxel', 'gemcitabine'], 'is_context_needed': True}]