Sentence: Combination therapy with irinotecan ( CPT-11 ) , 5-fluorouracil ( 5-FU ) and leucovorin is widely used for the treatment of metastatic colorectal cancer .
Drug combination annotation:
[{'class': 'POS', 'spans': ['irinotecan', 'leucovorin', '5-fluorouracil'], 'is_context_needed': True}]