Sentence: Thirty-three women diagnosed with metastatic breast cancer participated in a phase 1 clinical trial of a new combination of cyclophosphamide ( CTX ) and mitoxantrone ( MXT ) , with dose escalation of paclitaxel .
Drug combination annotation:
[{'class': 'COMB', 'spans': ['cyclophosphamide', 'mitoxantrone', 'paclitaxel'], 'is_context_needed': True}]