Sentence: Two large Phase III trials conducted in the Americas and across Europe , Australia , and Asia showed lower cumulative pregnancy rates in the NOMAC/E2 groups compared to the drospirenone ( DRSP ) 3 mg in combination with ethinyl estradiol ( EE ) 30 µg ( DRSP/EE ) groups but this difference was not statistically significant .
Drug combination annotation:
[{'class': 'POS', 'spans': ['drospirenone', 'ethinyl estradiol'], 'is_context_needed': False}]