Sentence: This study indicates that cyclophosphamide , doxorubicin , and methotrexate are , at best , marginally active as single agents , and new drugs with more efficacy are needed before combination chemotherapy can be expected to result in any meaningful prolongation of survival in non-small cell lung cancer .
Drug combination annotation:
[{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'methotrexate'], 'is_context_needed': True}]