Sentence: The clinical symptoms were relieved after combination of doxycycline , rifampicin , levofloxacin and amikacin for 6 weeks , only one patient with bone destruction needed orthopedic surgery .
Drug combination annotation:
[{'class': 'POS', 'spans': ['doxycycline', 'rifampicin', 'levofloxacin', 'amikacin'], 'is_context_needed': False}]