Sentence: We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that was marked by rapid tumor necrosis followed by massive hemorrhage shortly after bevacizumab and paclitaxel administration .
Drug combination annotation:
[{'class': 'NEG', 'spans': ['bevacizumab', 'paclitaxel'], 'is_context_needed': False}]