Sentence: At present , it seems to us that progress has not been made since Grignani reported a phase II cohort trial of sorafenib and sorafenib combined with everolimus for advanced osteosarcoma , which , in a sense , have become a milestone as a second-line therapy for osteosarcoma .
Drug combination annotation:
[{'class': 'COMB', 'spans': ['sorafenib', 'everolimus'], 'is_context_needed': True}]