Sentence: Forty patients with metastatic breast cancer who had received no previous cytotoxic therapy were treated with a combination chemotherapy program CMF ( P ) , which included methotrexate , 60 mg/m2 , and 5-fluorouracil , 700 mg/m2 intravenously on the first and eighth days , in addition to cyclophosphamide , 100 mg/m2 , and prednisone , 40 mg/m2 , by mouth daily from the first to the fourteenth day of a 28-day cycle .
Drug combination annotation:
[{'class': 'POS', 'spans': ['methotrexate', 'cyclophosphamide', 'prednisone', '5-fluorouracil'], 'is_context_needed': True}]