Sentence: Microdialysis-based pharmacokinetic studies demonstrated that administration of the P-gp inhibitor cyclosporin A resulted in increased brain levels of escitalopram without altering plasma escitalopram levels in the rat , thereby showing that P-gp restricts escitalopram transport across the blood-brain barrier ( BBB ) in vivo .
Drug combination annotation:
[{'class': 'POS', 'spans': ['cyclosporin', 'escitalopram'], 'is_context_needed': False}]