Sentence: Hypertensive rats in separate groups were treated with either candesartan ( 1 mg/kg body weight ) alone or a combination of candesartan ( 1 mg/kg body weight ) and rofecoxib ( 10 mg/kg body weight ) orally and daily for 6 weeks .
Drug combination annotation:
[{'class': 'NEG', 'spans': ['candesartan', 'rofecoxib'], 'is_context_needed': True}]