Sentence: Systemic treatments , and here in particular a combined therapeutic regimen of chemotherapy and electron beam , bexarotene , or denileukin diftitox , showed more adverse effects than topical or skin-directed treatments .
Drug combination annotation:
[{'class': 'NEG', 'spans': ['bexarotene', 'denileukin diftitox'], 'is_context_needed': False}]