Sentence: Using a FOLFOXIRI ( 5-fluorouracil [ 5-FU ] , irinotecan , and oxaliplatin ) combination regimen , patients with metastatic colorectal cancer now have the possibility of longer survival , but disappointingly , with increased toxicities .
Drug combination annotation:
[{'class': 'POS', 'spans': ['5-FU', 'irinotecan', 'oxaliplatin'], 'is_context_needed': False}]