Sentence: In metastastic patients , the combination of gemcitabine and cisplatin has become the new standard regimen due to a lower toxicity in comparison to the combination of methotrexate , vinblastine , doxorubicin , and cisplatin ( MVAC ) .
Drug combination annotation:
[{'class': 'POS', 'spans': ['gemcitabine', 'cisplatin'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [1, 2, 3], 'is_context_needed': True}]