Sentence: While 5-fluorouracil used as single agent in patients with metastatic colorectal cancer has an objective response rate around 20 % , the administration of combinations of irinotecan with 5-fluorouracil/folinic acid or oxaliplatin with 5-fluorouracil/folinic acid results in significantly increased response rates and improved survival .
Drug combination annotation:
[{'class': 'POS', 'spans': ['irinotecan', '5-fluorouracil/folinic'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}]