Sentence: Forty-eight patients were treated with mitoxantrone alone , 40 with mitoxantrone plus beta-interferon , 11 with fluorouracil plus folinic acid and the remaining four with adriamycin .
Drug combination annotation:
[{'class': 'COMB', 'spans': ['mitoxantrone', 'beta-interferon'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}]