Sentence: To determine if antiseptic central venous catheters impregnated with silver sulfadiazine and chlorhexidine ( antiseptic ) reduce bacterial adherence and biofilm formation without producing local or systemic toxicity .
Drug combination annotation:
[{'class': 'POS', 'spans': ['sulfadiazine', 'chlorhexidine'], 'is_context_needed': True}]