Sentence: Due to dose-limiting toxicity ( DLT ) in both patients ( elevated transaminases and thrombocytopenia ) , an additional three patients were treated on dose level -1 with trabectedin 0.7 mg/m2 plus gemcitabine 700 mg/m2 .
Drug combination annotation:
[{'class': 'NEG', 'spans': ['trabectedin', 'gemcitabine'], 'is_context_needed': True}]