Sentence: Patients were randomised to receive either four or eight courses of cytotoxic chemotherapy with cyclophosphamide , vincristine and etoposide and also randomised to receive , on disease progression , either second line chemotherapy ( methotrexate and doxorubicin ) or symptomatic treatment only .
Drug combination annotation:
[{'class': 'POS', 'spans': ['cyclophosphamide', 'vincristine', 'etoposide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [3, 4], 'is_context_needed': True}]