Sentence: A 29-year-old man with juvenile myoclonic epilepsy and medically refractory GTCS on a combination of levetiracetam and topiramate was started on lacosamide adjunctive therapy with the plan to replace topiramate .
Drug combination annotation:
[{'class': 'COMB', 'spans': ['levetiracetam', 'topiramate'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2], 'is_context_needed': True}]