Sentence: In this challenging field , aflibercept offers a good option for oxaliplatin-refractory mCRC patients when combined with irinotecan and 5-fluorouracil irrespective of prior anti-angiogenic treatment .
Drug combination annotation:
[{'class': 'POS', 'spans': ['aflibercept', 'irinotecan', '5-fluorouracil'], 'is_context_needed': False}]