Sentence: Systemic chemotherapy with vincristine , actinomycin D , plus cyclophosphamide ( VAC therapy ) , and etoposide plus cisplatin ( EP therapy ) were made according to Intergroup Rhabdomyosarcoma Study (IRS)-IV Regimen 45 .
Drug combination annotation:
[{'class': 'NEG', 'spans': ['vincristine', 'actinomycin D', 'cyclophosphamide', 'etoposide', 'cisplatin'], 'is_context_needed': True}]