Sentence: In the current study , we investigated the hypothesis that targeting of P-gp by diltiazem can enhance the cytotoxicity of gemcitabine and 5-FU against human pancreatic cancer cells .
Drug combination annotation:
[{'class': 'POS', 'spans': ['diltiazem', 'gemcitabine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}]