Sentence: The pupillary dilation caused by amantadine is not abolished by pretreatment with reserpine , or by combined pretreatment with reserpine and alpha-methyl-p-tyrosine , although the mydriasis is reduced by approximately 25 % .
Drug combination annotation:
[{'class': 'NEG', 'spans': ['amantadine', 'reserpine'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2, 3], 'is_context_needed': True}]