Sentence: Irinotecan and etoposide were combined using the ( d x 5)2 i.v . schedule for both drugs , in which irinotecan was given 2 h before or 2 h after the administration of etoposide .
Drug combination annotation:
[{'class': 'NEG', 'spans': ['Irinotecan', 'etoposide'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [2, 3], 'is_context_needed': True}]