Sentence: Hyper-CVAD , given in odd-number courses ( Courses 1 , 3 , 5 , and 7 ) , was alternated with methotrexate and cytarabine ( MTX/Ara-C ) , given in even-number courses ( Courses 2 , 4 , 6 , and 8) .
Drug combination annotation:
[{'class': 'POS', 'spans': ['methotrexate', 'cytarabine'], 'is_context_needed': True}]