Sentence: Significantly , genes regulated by both formoterol and budesonide were overrepresented in the genome ; moreover , budesonide-plus-formoterol induced and repressed 609 and 577 mRNAs , respectively , of which ~1/3 failed the cut-off criterion for either treatment alone .
Drug combination annotation:
[{'class': 'POS', 'spans': ['formoterol', 'budesonide'], 'is_context_needed': True}]