Sentence: Based on the FIRM-ACT trial , mitotane plus etoposide , doxorubicin , and cisplatin is now the established first-line cytotoxic therapy .
Drug combination annotation:
[{'class': 'POS', 'spans': ['mitotane', 'etoposide', 'doxorubicin', 'cisplatin'], 'is_context_needed': False}]