Sentence: Amphotericin B MICs were reduced upon combination with rifabutin from a mean of 0.65 microg/ml to a mean of 0.16 microg/ml against Aspergillus , and from a mean of 0.97 microg/ml to a mean of 0.39 microLg/ml against Fusarium ( P < 0.000001 for both ) .
Drug combination annotation:
[{'class': 'POS', 'spans': ['Amphotericin', 'rifabutin'], 'is_context_needed': True}]