Question: What role-playing game set in the Star Trek derived Star Fleet Universe was designed by Stephen V. Cole?

Context paragraphs:
Star Trek Online: Star Trek Online is a massively multiplayer online role-playing game (MMORPG) developed by Cryptic Studios based on the "Star Trek" series created by Gene Roddenberry.  The game is set in the 25th century, 30 years after the events of "".  "Star Trek Online" is the first massively multiplayer online role-playing game within the "Star Trek" franchise and was released for the Microsoft Windows platform in February 2010.  At launch, the game required a game purchase and a recurring monthly fee.  In January 2012, it relaunched with a tier of free-to-play access available.  After a public beta testing period, a completed version of the game was released for OS X in March 2014.  Due to insurmountable technical issues with the platform, however, support for OS X ended in February 2016.  By January 2014, the game had over 3.2 million accounts.  It was later released on PlayStation 4 and Xbox One in September 2016.

Prime Directive (role-playing game): Prime Directive is a role-playing game set in the "Star Trek"-derived Star Fleet Universe.  The game has gone through two different incarnations.

Stephen V. Cole: Stephen V. Cole is an American game designer and the CEO of Amarillo Design Bureau (also known as ADB or, incorrectly, Starfleet Games) which publishes "Star Fleet Battles", "Federation and Empire", "Federation Commander", "Prime Directive" (a series of RPGs for D20, D20M, and GURPS), and other wargames set in the Star Fleet Universe.  ADB became ADB, Inc., in 1999.

Star Trek: Adventure Gaming in the Final Frontier: Star Trek: Adventure Gaming in the Final Frontier is a role-playing game set in the fictional "Star Trek" universe.  The game was published and edited by Heritage Models from 1978 until Heritage Models dropped the "Star Trek" gaming license.

Star Fleet Battles: Star Fleet Battles (SFB) is a tactical board wargame set in an offshoot of the Star Trek setting called the Star Fleet Universe.  Originally created in 1979 by Stephen V. Cole, it has had four major editions.  The current edition is published by Amarillo Design Bureau as "Star Fleet Battles, Captain's Edition".  "Star Fleet Battles" was inducted into the Academy of Adventure Gaming, Arts, & Design Hall of Fame in 2005 where they stated that ""Star Fleet Battles" literally defined the genre of spaceship combat games in the early 1980s, and was the first game that combined a major license with 'high re-playability'."

Star Trek: The Next Generation Role-playing Game: Star Trek: The Next Generation Role-playing Game is a role-playing game set in the fictional "Star Trek" universe, designed by Last Unicorn Games (LUG).  Due to licensing issues, LUG did not release the game as a single core rulebook and setting supplements for the various series, but instead intended to release a corebook for every series.  The "Star Trek" license was lost to Decipher before a "" rulebook could be released.

Federation Commander: Federation Commander is a tactical starship combat board wargame system, produced and developed by Amarillo Design Bureau Inc. (ADB) It is designed to represent combat between vessels of various factions in the Star Fleet Universe, such as the United Federation of Planets and the Klingon Empire.  The Star Fleet Universe is based upon a licence to use properties in the fictional Star Trek universe as it stood in 1979.  Thus it includes the original series and the animated series as well as fan contributions but diverges from then and does not include anything from the movies or any subsequent television series.  Much of the combat in Federation Commander is said to take place around the time of the fictional "General War", a large scale conflict in the Milky Way that involved prolonged conflict between a multitude of star-faring cultures.

Agents of Gaming: Agents of Gaming was a game design studio that started out in January 1992 by Bruce Graw.  The company's original purpose was to run Galactic Conquest, the play-by-mail game which became Star Fleet Warlord.  Galactic Conquest had originally been run as a hobby (first created in late 1989), but proved its worth in the first eight games as a legitimate play-by-mail game.  The public debut came at Gen Con/Origins 1992, followed shortly by a deal to make it an official Star Fleet Universe product (a change of the name to the Star Fleet Warlord).

Star Fleet Universe: The Star Fleet Universe (SFU) is the variant of the "Star Trek" fictional universe detailed in the series of Star Fleet Battles games (board-, card-, and role-playing) from Amarillo Design Bureau Inc. and used as reference for the series of computer games. Its source material stems from the original and animated series of "Star Trek" as well as from other "fan" sources, such as "Star Trek Star Fleet Technical Manual".  In addition, it also includes a substantial number of new races and technologies, such as the Hydran Kingdom, the Inter-Stellar Concordium and the Andromedans.

Federation and Empire: Federation and Empire ("F&E") is a strategic-level board wargame set in the fictional Star Fleet Universe spinoff of "Star Trek", currently published by Amarillo Design Bureau Inc. (ADB).  It is a stand-alone product, but has sometimes been considered the official campaign generator for "Star Fleet Battles".

Supporting paragraphs: Stephen V. Cole Prime Directive (role-playing game)
Answer: Prime Directive