Question: Isaac McCoy was an advocate of what policy where Native Americans were forcibly removed from their ancestral homelands in the eastern United States to lands west of the Mississippi River?

Context paragraphs:
Connecticut Land Company: The Connecticut Company or Connecticut Land Company (e.-1795) was a post-colonial land speculation company formed in the late eighteenth century to survey and encourage settlement in the eastern parts of the newly chartered Connecticut Western Reserve of the former "Ohio Country" and a prized-part of the Northwest Territory)—a post-American Revolutionary period region, that was part of the lands-claims settlement adjudicated by the new United States government regarding the contentious conflicting claims by various Eastern Seaboard states on lands west of the gaps of the Allegheny draining into the Allegheny, Monongahela, and Ohio Rivers. Under the arrangement, all the states gave up their land claims west of the Alleghenies to the Federal government save for parts parceled out to each claimant state.  Western Pennsylvania was Pennsylvania's part, and the Connecticut Western Reserve was the part aportioned to Connecticut's claim.  The specific Connecticut Western Reserve lands were the northeastern part of the greater Mississippi drainage basin lands just west of those defined as part of Pennsylvania's claims settlement (Western Pennsylvania).

Trail of Tears: The Trail of Tears was a series of forced removals of Native American nations from their ancestral homelands in the Southeastern United States to an area west of the Mississippi River that had been designated as Indian Territory.  The forced relocations were carried out by various government authorities following the passage of the Indian Removal Act in 1830.  The relocated people suffered from exposure, disease, and starvation while en route, and more than four thousand died before reaching their various destinations.  The removal included members of the Cherokee, Muscogee (Creek), Seminole, Chickasaw, and Choctaw nations.  The phrase "Trail of Tears" originated from a description of the removal of the Cherokee Nation in 1838.

Indian removal: Indian removal was a policy of the United States government in the 19th century whereby Native Americans were forcibly removed from their ancestral homelands in the eastern United States to lands west of the Mississippi River, thereafter known as Indian Territory.  In a matter that remains one of debate by scholars, description of the policy—which clearly contributed to devastation in numbers, freedom and prosperity for those displaced—is sometimes elevated to being one of long-term genocide of Native Americans, in any case, a consequence of actions first by European settlers to North America in the colonial period, then by the United States government and its citizens until the mid-20th century.  The policy traced its direct origins to the administration of James Monroe, though it addressed conflicts between European Americans and Native Americans that had been occurring since the 17th century, and were escalating into the early 19th century as white settlers were continually pushing westward.  The Indian Removal Act was the key law that forced the removal of the Indians, and was signed into law by President Andrew Jackson on May 28, 1830.

History of slavery in Indiana: Slavery in Indiana occurred between the time of French rule during the late seventeenth century and 1826, with a few traces of slavery afterward.  When the United States first forcibly removed the Native Americans from the region, slavery was accepted as a necessity to keep peace with the Indians and the French.  When the Indiana Territory was established in 1800, William Henry Harrison, a former slaveholder, was appointed governor and slavery continued to be tolerated through a series of laws enacted by the appointed legislature.

Isaac McCoy: Isaac McCoy (June 13, 1784 – June 21, 1846) was a Baptist missionary among the Native Americans in present-day Indiana, Michigan and Missouri.  He was an advocate of Indian removal from the eastern United States, proposing an Indian state in what is now Kansas, Nebraska, and Oklahoma.  He also played an instrumental role in the founding of Grand Rapids, Michigan and Kansas City, Missouri.

San Carlos Apache Indian Reservation: The San Carlos Apache Indian Reservation, in southeastern Arizona, United States, was established in 1872 as a reservation for the Chiricahua Apache tribe as well as surrounding Yavapai and Apache bands forcibly removed from their original homelands under a strategy devised by General Crook of using an Apache to catch an Apache.  Also known as "Hell's Forty Acres" under United States occupation because of deplorable health and environmental conditions, today's San Carlos Apaches successfully operate a Chamber of Commerce, the Apache Gold Casino, a Language Preservation program, a Culture Center, and a Tribal College.

Chickasaw Nation: The Chickasaw Nation is a federally recognized Native American nation, located in Oklahoma.  They are one of the members of the Five Civilized Tribes.  The Chickasaw Nation was created after the Chickasaw people were forcibly removed by the US federal government to Indian Territory in the 1830s.  Their removal was part of a larger effort by the federal government to relocate Native American peoples from the eastern side of the Mississippi River; in the Southeast, these were the Cherokee, Muscogee (Creek), Seminole, Chickasaw, and Choctaw nations.  The removals became known as the "Trail of Tears".

Thomas Jefferson and Native Americans: Thomas Jefferson believed Native American peoples to be a noble race who were "in body and mind equal to the whiteman" and were endowed with an innate moral sense and a marked capacity for reason.  Nevertheless, Jefferson developed plans for Indian Removal to lands West of the Mississippi, including forced removal such as that carried out by later presidents in the Trail of Tears.  Before and during his presidency, Jefferson discussed the need for respect, brotherhood, and trade with the Native Americans, and he initially believed that causing them to adopt European-style agriculture and modes of living would allow them to quickly "progress" from "savagery" to "civilization".  Yet beginning in 1803, Jefferson's private letters show increasing support for a policy of removal.

Windrose Site: The Windrose Site is a 19th-century Potawatomi village site in Kankakee County, Illinois.  The site is likely associated with a Potawatomi village named "Rock" or "Little Rock"; it was occupied from circa 1775 until the Potawatomi were forcibly removed from Illinois in the 1830s.  Many of the artifacts recovered from the site are related to the fur trade, a large part of the Potawatomi economy and a source of cultural interaction between the Potawatomi and Europeans.  The majority of the artifacts reflect traditional Potawatomi culture, including smoking pipes used for religious rituals.  Items deriving from the U.S. government's efforts at the time to force European culture upon Native Americans represent less than 5% of those found at the site, a sign that these efforts were not particularly successful with the Potawatomi.

Native Americans in the American Civil War: Native Americans in the American Civil War saw Native American individuals, bands, tribes, and nations participate in numerous skirmishes and battles.  Native Americans served in both the Union and Confederate military during the American Civil War.  They were found in the Eastern, Western, and Trans-Mississippi Theaters.  At the outbreak of the war, for example, the majority of the Cherokees sided with the Union, but soon after allied with the Confederacy.  Native Americans fought knowing they might jeopardize their sovereignty, unique cultures, and ancestral lands if they ended up on the losing side of the Civil War.  28,693 Native Americans served in the Union and Confederate armies during the Civil War, participating in battles such as Pea Ridge, Second Manassas, Antietam, Spotsylvania, Cold Harbor, and in Federal assaults on Petersburg.

Supporting paragraphs: Isaac McCoy Indian removal
Answer: Indian removal