Question: The highway through the Ridge and Valley Province ends at interchange?

Context paragraphs:
James River Gorge: The James River Gorge is a water gap created by the James River in Central Virginia.  The Gorge is 2433 ft deep as measured from Highcock Knob 3073 ft to the James River 640 ft and is approximately 9.3 mi long.  The James River forms in western Virginia near the border of West Virginia and initially flows south through the ridge and valley province of the Allegheny Mountains, turning northeast when it comes to the western edge of the Blue Ridge Mountains near Buchanan, Virginia.  From Buchanan the river flows along the base of the Blue Ridge Mountains until it joins the Maury River near the town of Glasgow, Virginia and then it turns southeast and begins its descent over the Balcony Falls rapids and through the James River Gorge.  The rocks of the gorge are metamorphic in nature with the oldest exposed outcrops being from the Proterozoic Era.

Geology of Pennsylvania: The Geology of Pennsylvania consists of six distinct physiographic provinces, three of which are subdivided into different sections.  Each province has its own economic advantages and geologic hazards and plays an important role in shaping everyday life in the state.  They are: (listed from the southeast corner to the northwest corner) the Atlantic Coastal Plain Province, the Piedmont Province, the New England Province, the Ridge and Valley Province, the Appalachian Plateau Province, and the Central Lowlands Province.

Shenandoah Valley: The Shenandoah Valley is a geographic valley and cultural region of western Virginia and the Eastern Panhandle of West Virginia in the United States.  The valley is bounded to the east by the Blue Ridge Mountains, to the west by the eastern front of the Ridge-and-Valley Appalachians (excluding Massanutten Mountain), to the north by the Potomac River and to the south by the James River.  The cultural region covers a larger area that includes all of the valley plus the Virginia highlands to the west, and the Roanoke Valley to the south.  It is physiographically located within the Ridge and Valley province and is a portion of the Great Appalachian Valley.

Ridge-and-Valley Appalachians: The Ridge-and-Valley Appalachians, also called the Ridge and Valley Province or the Valley and Ridge Appalachians, are a physiographic province of the larger Appalachian division and are also a belt within the Appalachian Mountains extending from southeastern New York through northwestern New Jersey, westward into Pennsylvania and southward into Maryland, West Virginia, Virginia, Kentucky, Tennessee, Georgia and Alabama.  They form a broad arc between the Blue Ridge Mountains and the Appalachian Plateau physiographic province (the Allegheny and Cumberland Plateaus).  They are characterized by long, even ridges, with long, continuous valleys in between.

Kittatinny Mountain: Kittatinny Mountain (Lenape: Kitahtëne) is a long ridge traversing across northwestern New Jersey running in a northeast-southwest axis, a continuation across the Delaware Water Gap of Pennsylvania's Blue Mountain Ridge (also known as Kittatinny Ridge).  It is the first major ridge in the far northeastern extension of the Ridge and Valley province of the Appalachian Mountains, and reaches its highest elevation (the state's highest), 1,803 feet, at High Point in Montague Township.  Kittatinny Mountain forms the eastern side of Wallpack Valley; the western side comprises the Wallpack Ridge (highest elevation: 928 ft above sea level.

U.S. Route 522 in Pennsylvania: U.S. Route 522 (US 522) is a part of the U.S. Highway System that runs from Powhatan, Virginia to Selinsgrove, Pennsylvania.  In Pennsylvania, the U.S. highway runs 127.5 mi from the Maryland state line near Warfordsburg north to its northern terminus at US 11 and US 15 in Selinsgrove.  US 522 passes through the Ridge and Valley Province of the Appalachian Mountains of central Pennsylvania, connecting Hancock, Maryland on the Potomac River with McConnellsburg, Mount Union, Lewistown, Middleburg, and Selinsgrove on the Susquehanna River.  The U.S. highway is part of the National Highway System along its concurrency with Interstate 70 (I-70) from the Maryland state line to Warfordsburg and from US 522's interchange with the Pennsylvania Turnpike (I-76) to Selinsgrove.

U.S. Route 522 in West Virginia: U.S. Route 522 (US 522) is a part of the U.S. Highway System that runs from Powhatan, Virginia to Selinsgrove, Pennsylvania.  In West Virginia, the U.S. highway runs 19.0 mi from the Virginia state line near Ridge north to the Maryland state line at the Potomac River in Hancock just south of Hancock, Maryland.  US 522 passes through Ridge and Valley Province of the Appalachian Mountains in the Eastern Panhandle of West Virginia.  The portion of the U.S. highway in West Virginia serves to connect Winchester with Hancock via Berkeley Springs, the county seat of Morgan County.  US 522 is part of the National Highway System for its entire length in West Virginia.

Blue Ridge Mountains: The Blue Ridge Mountains are a physiographic province of the larger Appalachian Mountains range.  This province consists of northern and southern physiographic regions, which divide near the Roanoke River gap.  The mountain range is located in the eastern United States, starting at its southernmost portion in Georgia, then ending northward in Pennsylvania.  To the west of the Blue Ridge, between it and the bulk of the Appalachians, lies the Great Appalachian Valley, bordered on the west by the Ridge and Valley province of the Appalachian range.

Geology of Bedford County, Pennsylvania: Bedford County, Pennsylvania is situated along the western border of the Ridge and Valley physiographic province, which is characterized by folded and faulted sedimentary rocks of early to middle Paleozoic age.  The northwestern border of the county is approximately at the Allegheny Front, a geological boundary between the Ridge and Valley Province and the Allegheny Plateau (characterized by relatively flat-lying sedimentary rocks of late Paleozoic age).  (PA Geological Survey Map 13)

Pennsylvania Route 75: Pennsylvania Route 75 (PA 75) is a 71.2 mi north–south state highway located in central Pennsylvania.  The southern terminus is at the Mason–Dixon line in Montgomery Township, where the road continues into Maryland as Maryland Route 494 (MD 494).  The northern terminus is at an interchange with U.S. Route 22 (US 22) and US 322 northeast of Port Royal.  PA 75 is a two-lane undivided road that passes through the Ridge-and-Valley Appalachians in Franklin and Juniata counties.  The route heads north from the Maryland border in Franklin County to Mercersburg, where it runs concurrent with PA 16 and PA 416.  From Mercersburg, PA 75 heads north and crosses US 30 in Fort Loudon before it runs northeast through a long valley, where it has an interchange with the Pennsylvania Turnpike (Interstate 76 or I-76) in Willow Hill.  The route turns north and heads into Juniata County, where it continues through another valley.  PA 75 passes through Port Royal and crosses the Juniata River before it comes to its terminus at US 22/US 322.

Supporting paragraphs: Pennsylvania Route 75 Ridge-and-Valley Appalachians
Answer: U.S. Route 22