Question:  Michael Robert "Mike" Ekstrom made his MLB debut striking out a Dominican-American professional baseball outfielder who was one of 25 players to hit what?

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Starling Marte: Starling Javier Marte (born October 9, 1988) is a Dominican professional baseball outfielder for the Pittsburgh Pirates of Major League Baseball (MLB).  He made his MLB debut in 2012.  Marte is an MLB All-Star and a two-time Gold Glove Award winner.

Jorge Soler: Jorge Carlos Soler Castillo (born February 25, 1992) is a Cuban-born professional baseball outfielder for the Kansas City Royals of Major League Baseball (MLB).  Soler played for the Cuban national baseball team in international competition.  He defected from Cuba in 2011, seeking a career in MLB.  After establishing his residency in Haiti, Soler signed a nine-year contract with the Chicago Cubs.  He made his MLB debut in 2014.  The Cubs traded Soler to the Royals after the 2016 season.

Phillip Ervin: Phillip S. Ervin (born July 15, 1992) is an American professional baseball outfielder for the Cincinnati Reds of Major League Baseball (MLB).  He played college baseball for Samford University before the Reds selected him in the first round of the 2013 MLB draft.  He made his MLB debut in April 2017.

Robinson Canó: Robinson José Canó Mercedes (] ; born October 22, 1982), often shortened to Robbie Cano, is a Dominican-American professional baseball second baseman for the Seattle Mariners of Major League Baseball.  He made his MLB debut with the New York Yankees in 2005 and played for them through 2013.

Manny Ramirez: Manuel Arístides Ramírez Onelcida (born May 30, 1972) is a Dominican-American professional baseball outfielder for the Kōchi Fighting Dogs of the Shikoku Island League Plus.  He played in Major League Baseball (MLB) for parts of 19 seasons.  He played with the Cleveland Indians, Boston Red Sox, Los Angeles Dodgers, Chicago White Sox, and Tampa Bay Rays before playing one season in the Chinese Professional Baseball League.  Ramirez is recognized for having had great batting skill and power.  He was a nine-time Silver Slugger and was one of 25 players to hit 500 career home runs. His 21 grand slams are third all-time, and his 29 postseason home runs are the most in MLB history.  He appeared in 12 All-Star Games, with a streak of eleven consecutive games beginning in 1998 that included every season that he played with the Red Sox.

Clint Frazier: Clint Jackson Frazier (born September 6, 1994), nicknamed "Red Thunder", is an American professional baseball outfielder for the New York Yankees of Major League Baseball (MLB).  A top prospect for the 2013 MLB Draft, the Cleveland Indians chose Frazier with the fifth overall selection.  The Indians traded Frazier (among other prospects) to the Yankees in 2016 for relief pitcher Andrew Miller.  Frazier made his MLB debut in 2017.

Matt Szczur: Matthew Francis Szczur ( ; born July 20, 1989) is an American professional baseball outfielder for the San Diego Padres of Major League Baseball (MLB).  He played football and baseball at Villanova University prior to signing a professional contract with the Chicago Cubs in January 2011.  He made his MLB debut with the Cubs in 2014, and was traded to the Padres in 2017 after refusing to accept a minor league assignment with the Chicago Cubs.

Mike Ekstrom: Michael Robert "Mike" Ekstrom (born August 30, 1983) is an American former professional baseball pitcher.  Drafted by the San Diego Padres in the 12th round (342nd overall) of the 2004 Major League Baseball Draft, he made his MLB debut on September 10, , striking out Manny Ramirez and pitching two scoreless innings.

Kyle Schwarber: Kyle Joseph Schwarber (born March 5, 1993) is an American professional baseball outfielder for the Chicago Cubs of Major League Baseball (MLB).  He played college baseball for the Indiana Hoosiers.  He was drafted by the Cubs in the first round of the 2014 MLB draft, and made his MLB debut during the 2015 season.

Michael Conforto: Michael Thomas Conforto (born March 1, 1993), nicknamed Scooter, is an American professional baseball outfielder for the New York Mets of Major League Baseball (MLB).  After he played college baseball for the Oregon State Beavers, the Mets selected him in the first round of the 2014 MLB draft with the 10th overall pick.  He made his MLB debut in 2015.

Supporting paragraphs: Mike Ekstrom Manny Ramirez
Answer: 500 career home runs.