Question: Which first setters was the place near an Interstate Highway that follows the U.S. Route 78 in Mississippi named for?

Context paragraphs:
Mooreville, Mississippi: Mooreville is a census-designated place located in Lee County, Mississippi.  It is part of the Tupelo Micropolitan Statistical Area.  Mooreville is approximately 4 mi west of Dorsey and approximately 4 mi east of Tupelo on Mississippi Highway 178 near Interstate 22.  It was named for the Moore family, its first settlers.

Mississippi Highway 23: Mississippi Highway 23 (MS 23) is a state highway in Mississippi.  The route starts at MS 25 in the town of Smithville.  It travels northeastward through the forests of eastern Itawamba County.  The highway intersects Interstate 22 (I-22) and U.S. Route 78 (US 78) in Tremont.  MS 23 ends at the Mississippi–Alabama state line, just west of Red Bay.

U.S. Route 278: U.S. Route 278 is a parallel route of U.S. Route 78.  It currently runs for 1,074 miles (1,728 km) from Hilton Head Island, South Carolina to Wickes, Arkansas at U.S. Route 71/U.S. Route 59.  It is longer than its parent highway, US 78.  US 278 passes through the states of South Carolina, Georgia, Alabama, Mississippi, and Arkansas.  This highway passes through the cities and towns of Augusta, Covington, Atlanta, Powder Springs, Hiram, Dallas, Rockmart, and Cedartown, Georgia; Gadsden and Cullman, Alabama; Tupelo, Oxford, and Greenville, Mississippi; and Monticello and Hope, Arkansas.

Interstate 26: Interstate 26 (I-26) is a nominally east-west (but physically more northwest-southeast diagonal) main route of the Interstate Highway System in the Southeastern United States.  I-26 runs from the junction of U.S. Route 11W and U.S. Route 23 in Kingsport, Tennessee, generally southeastward to U.S. Route 17 in Charleston, South Carolina.  The portion from Mars Hill, North Carolina, east (compass south) to Interstate 240 in Asheville, North Carolina, has signs indicating I-26 because the highway does not yet meet all of the Interstate Highway standards.  A short realignment as an improvement in the freeway was also planned in Asheville, but has been postponed indefinitely due to North Carolina's budget shortfalls.

Interstate 40: Interstate 40 (I-40) is a major east-west Interstate Highway running through the south-central portion of the United States generally north of Interstate 10 and Interstate 20 but south of Interstate 70.  The western end is at Interstate 15 in Barstow, California; its eastern end is at a concurrency of U.S. Route 117 and North Carolina Highway 132 in Wilmington, North Carolina.  It is the third longest interstate in the United States, behind Interstate 80 and Interstate 90.  Much of the western part of I-40, from Oklahoma City to Barstow, parallels or overlays the historic U.S. Route 66, east of Oklahoma City the route generally parallels U.S. Route 64 and U.S. Route 70.  I-40 runs through many major cities including Albuquerque, New Mexico; Amarillo, Texas; Oklahoma City, Oklahoma; Little Rock, Arkansas; Memphis, Tennessee; Nashville, Tennessee; Knoxville, Tennessee; and Raleigh, North Carolina.

Capleville, Tennessee: Capleville is an unincorporated community in Shelby County, Tennessee, United States, southeast of Memphis and just north of the Mississippi border.  It is located 0.5 mi.  east of the Memphis International Airport, starting 1 mi.  west of the intersection of State Routes 176 and 175, and heading east along State Route 175 (Shelby Drive) crossing U.S. Route 78.  Most of the area has been incorporated into the City of Memphis and since has become a large industrial center due to its proximity to the airport and Lamar Avenue (U.S. Route 78) which becomes a divided freeway after State Route 175.

Interstate 95 in Delaware: Interstate 95 (I-95) is an Interstate highway running along the East Coast of the United States from Miami, Florida north to the Canadian border in Houlton, Maine.  In the state of Delaware, the route runs for 23.43 mi across the Wilmington area in northern New Castle County from the Maryland state line near Newark northeast to the Pennsylvania state line in Claymont.  I-95 is the only primary (2-digit) Interstate highway that enters Delaware, although it also has two auxiliary routes within the state (I-295 and I-495).  Between the Maryland border and Newport, I-95 follows the Delaware Turnpike or John F. Kennedy Memorial Highway, a toll road with a toll plaza near the state line.  In Newport, the interstate has a large interchange with Delaware Route 141 (DE 141) and the southern termini of I-295 and I-495, the latter interstate providing a bypass of Wilmington.  I-95 heads north through the heart of Wilmington concurrent with U.S. Route 202 (US 202) on the Wilmington Expressway.  Past Wilmington, I-95 continues northeast to Claymont, where I-495 rejoins the route right before the Pennsylvania state line.

Interstate 380 (California): Interstate 380 (I-380) is a short 1.7-mile (2.7 km) east–west spur Interstate Highway in the San Francisco Bay Area of Northern California, connecting Interstate 280 in San Bruno to U.S. Route 101 near the San Francisco International Airport (SFO).  The highway primarily consists of only three intersections: I-280, El Camino Real (State Route 82), and U.S. 101.  Like nearby I-280, I-380 never connects to Interstate 80, its parent Interstate Highway.  However, there is no rule that says that spur routes need to.  (Similarly, the spur route Interstate 795 branches off from Interstate 695, a beltway around Baltimore, and is only indirectly linked to Interstate 95.)

Interstate 22: Interstate 22 (I-22) is an Interstate Highway that follows the U.S. Route 78 (US 78) corridor on a 213 mi route from Byhalia, Mississippi south of Memphis, Tennessee, to Birmingham, Alabama.  I-22 indirectly connects I-240, I-40, I-55, and I-69 in the northwest with I-65 and I-20/I-59 in the southeast.  When designated in 2012, it was designed to close a gap in the Interstate network allowing more direct connections between cities in the southeast (such as Atlanta and Birmingham) with those of the Great Plains (such as Oklahoma City and St. Louis).

Interstate 85 in Virginia: Interstate 85 (I-85) is a part of the Interstate Highway System that runs from Montgomery, Alabama to Petersburg, Virginia.  In Virginia, the Interstate Highway runs 68.64 mi from the North Carolina state line near Bracey north to I-95 in Petersburg.  I-85 passes through the eastern part of Southside Virginia, where it parallels U.S. Route 1 (US 1) from Petersburg, where the highway runs concurrently with US 460, to south of South Hill, where the highway intersects Southside's major east–west highway, US 58.  The Interstate Highway is the primary connection between the Richmond–Petersburg metropolitan area and the Research Triangle and other major metropolitan areas of North Carolina.  Like all mainline Interstate Highways, I-85 is a part of the National Highway System for its entire length in Virginia.

Supporting paragraphs: Mooreville, Mississippi Interstate 22
Answer: the Moore family