Question: Which major station lies almost exactly 300 miles north of London on the West Coast Main Line?

Context paragraphs:
Coronation Scot: The Coronation Scot was a named express passenger train of the London, Midland and Scottish Railway inaugurated in 1937 for the coronation of King George VI and Queen Elizabeth which ran until the start of the war in 1939.  It ran on the West Coast Main Line between London (Euston station) and Glasgow (Central station), stopping at Carlisle for crew change and to pick up and set down passengers to and from London only.  The service was designed to compete with the rival services on the East Coast Main Line, for prestigious London to Scotland traffic.  It was scheduled to complete the journey from London to Glasgow in 6 hours 30 minutes.

Hest Bank railway station: Hest Bank railway station was opened by the Lancaster and Carlisle Railway (L&CR) three miles north of Lancaster Castle railway station.  The line had been authorised in 1844 and a station was proposed for the village of Hest Bank, Lancashire, the following year.  It opened in 1846 along with the line.  The station continued to serve the village of Hest Bank until its closure in 1969.  The site remains notable as being the point at which the present-day West Coast Main Line (WCML) comes nearest to the west coast.  Views of Morecambe Bay can be glimpsed from trains on this section of the line.

West Coast Main Line: The West Coast Main Line (WCML) is one of the most important railway corridors in the United Kingdom, connecting the major cities of London, Birmingham, Glasgow, Liverpool and Manchester.  It is one of the busiest mixed-traffic railway routes in Europe, carrying a mixture of intercity rail, regional rail, commuter rail and rail freight traffic.  The core route of the WCML runs from London to Glasgow, with branches diverging to Birmingham, Manchester and Liverpool, totalling a route mileage of 700 mi .  Services from London to North Wales and Edinburgh also run via the WCML; however the main London-Edinburgh route is the East Coast Main Line.  In addition, several sections of the WCML form part of the suburban railway systems in London, Birmingham, Manchester and Glasgow, with many more smaller commuter stations, as well as providing links to more rural towns.

Preston railway station: Preston railway station serves the city of Preston in Lancashire, England, and is a major station on the West Coast Main Line, and is the notional half-way point on the WCML between London Euston and Glasgow Central 194 miles from Glasgow Central and 206 from London Euston although the actual half-way point is at Leyland, approximately 6 miles south.  It is served by Northern, Virgin Trains, and TransPennine Express services, plus Caledonian Sleeper overnight services between London and Scotland.

Hemel Hempstead railway station: Hemel Hempstead railway station is on the West Coast Main Line, on the western edge of the town of Hemel Hempstead, Hertfordshire, England.  The station is 24+1/2 mi north-west of London Euston on the West Coast Main Line.  Hemel Hempstead is managed by London Midland and all train services are operated by London Midland and Southern.

Tweedmouth railway station: Tweedmouth railway station was a railway station which served the Tweedmouth area of Berwick-on-Tweed in Northumberland, England.  It was located on the East Coast Main Line.  As well as a railway station for passengers, it was also the main service yard and goods yard between Newcastle upon Tyne and Edinburgh.  Also Tweedmouth station was the terminus for the Tweed Valley Railway line (opened in 1849), which connected the East Coast Main Line with the Waverley Line at Newtown St. Boswells.  The station lies to the south of the Royal Border Bridge.

Waterbeach railway station: Waterbeach is a railway station serving the large village of Waterbeach in Cambridgeshire, England.  The station lies on the Fen Line from Cambridge to King's Lynn, electrified at 25 kV AC overhead.  The station is 61.01 mi from London Liverpool Street via the West Anglia Main Line and 63.29 mi from London King's Cross via the East Coast Main Line.

Runcorn railway station: Runcorn railway station is in the town of Runcorn in Cheshire, north-west England.  The station lies on the Liverpool branch of the West Coast Main Line between Weaver Junction and Liverpool South Parkway and is managed by Virgin Trains.

Lockerbie railway station: Lockerbie railway station lies on the West Coast Main Line between Carlisle and Carstairs in Lockerbie, Dumfries and Galloway, Scotland.

Carlisle railway station: Carlisle railway station, also known as Carlisle Citadel station, is a Grade II* listed railway station serving the city of Carlisle, Cumbria, England, and is a major station on the West Coast Main Line, lying 102 mi south east of Glasgow Central , and 299 mi north north west of London Euston .  It is also the northern terminus of the celebrated Settle and Carlisle Line – notionally (and historically) a continuation of the Midland Main Line from Leeds , Sheffield and ultimately London St Pancras .

Supporting paragraphs: Carlisle railway station West Coast Main Line
Answer: Carlisle