Question: "Holiday Special" is the third episode in the twenty-first season of the American animated television series "South Park", the twenty-first season of the American animated sitcom, premiered on Comedy Central on which date?

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Medicinal Fried Chicken: "Medicinal Fried Chicken" is the third episode of the fourteenth season of the American animated television series "South Park", and the 198th episode of the series overall.  It originally aired on Comedy Central in the United States on March 31, 2010.  In the episode, the South Park KFC is replaced by a medical marijuana dispensary, and Cartman gets involved in black market selling the KFC chicken.  Meanwhile, Randy Marsh gets a medical referral for marijuana by giving himself testicular cancer, which makes his testicles grow to grotesquely huge proportions.

White People Renovating Houses: "White People Renovating Houses" is the first episode in the twenty-first season of the American animated television series "South Park".  It is the 278th episode of the series overall, and first aired on Comedy Central in the United States on September 13, 2017.

Lice Capades: "Lice Capades" is the third episode in the eleventh season of the American animated television series "South Park".  The 156th episode of the series overall, it first aired on Comedy Central in the United States on March 21, 2007.  In the episode, all the students at South Park Elementary are checked for head lice and, to his horror, Clyde discovers that he has lice.  He tries to hide it from his classmates, knowing they will make fun of (if not, torture) him.  The episode was written and directed by series co-creator Trey Parker.

South Park (season 21): The twenty-first season of the American animated sitcom "South Park" premiered on Comedy Central on September 13, 2017, and will contain ten episodes.

Major Boobage: "Major Boobage" is the third episode in season 12 of the American animated television series "South Park".  The 170th episode of the series overall, it originally aired on Comedy Central in the United States on March 26, 2008.  The episode was co-written by series creators Trey Parker and Matt Stone; it was the first South Park episode since 2000 not solely written by Parker, ending a streak of 120 consecutive straight solo episodes.  The previous episode co-written by Stone was "The Tooth Fairy's Tats 2000".

Put It Down (South Park): "Put It Down" is the second episode in the twenty-first season of the American animated television series "South Park".  The 279th episode of the series overall, it first aired on Comedy Central in the United States on September 20, 2017.

Rednecks and Broomsticks: "Rednecks and Broomsticks" is the seventh episode in the twenty-first season of the American animated television series "The Simpsons".  It originally aired on the Fox network in the United States on November 29, 2009.  In the episode, Lisa befriends three teenaged Wiccans after getting lost in the woods during a game of hide-and-seek, and must clear her new friends' names when they are accused of cursing the townspeople with their supposed witchcraft.  Meanwhile, Homer befriends Cletus after learning that he and his friends make their own moonshine.

South Park (season 15): The fifteenth season of the American animated sitcom "South Park" began airing on Comedy Central on April 27, 2011 and ended on November 16, 2011.  In response to reactions to the mid-season finale episode "You're Getting Old", which seemed to insinuate that creators Trey Parker and Matt Stone were wrapping up the series, Comedy Central proclaimed through the media that "South Park" was renewed for two more seasons, and the duo were signed through 2013.  Shortly before the airing of the season finale episode "The Poor Kid", "South Park" was extended again until 2016, taking the show to 20 seasons.  Parker was the director and writer for all episodes, and Robert Lopez was the writer in this eleventh episode for the fifteenth season.

Holiday Special (South Park): "Holiday Special" is the third episode in the twenty-first season of the American animated television series "South Park".  The 280th episode of the series overall, it first aired on Comedy Central in the United States on September 27, 2017.

Super Best Friends: "Super Best Friends" is the third episode of the fifth season of the American animated television series "South Park", and the 68th episode of the series overall.  It first aired on Comedy Central in the United States on July 4, 2001.  In the episode, Stan, Kyle, Cartman and Kenny discover the magician David Blaine performing in South Park and decide to join his cult, the Blaintologists.  Stan quickly finds out that the Blaintologists are not as nice as everyone thinks and tries to convince the other boys they've been brainwashed, and have forsaken their friends and families.  Teaming up with Jesus, Stan calls upon the Super Best Friends, a parody of the Super Friends, to destroy Blaine and thwart the mass suicide pact he has launched.

Supporting paragraphs: Holiday Special (South Park) South Park (season 21)
Answer: September 13, 2017