Question: Which Route 22 runs through a major city?

Context paragraphs:
New York State Route 22: New York State Route 22 (NY 22) is a north–south state highway in eastern New York, in the United States.  It runs parallel to the state's eastern edge from the outskirts of New York City to the hamlet of Mooers in Clinton County.  At 337 mi , it is the state's longest north–south route and the third longest overall, after NY 5 and NY 17.  Many of the state's major east–west roads intersect with Route 22 just before crossing the state line into the neighboring New England states.

New Jersey Route 122: Route 122 is a short, 2.42 mi long state highway in Warren County, New Jersey.  The route runs from Warren County Route 678 and Pursel Street in Phillipsburg to an intersection with U.S. Route 22 in Pohatcong Township.  The route is a former alignment of U.S. Route 22, designated in 1926.  The route became U.S. Route 22 Alternate until 1993, when the route was decommissioned and replaced by County Route 678 and Route 122.

U.S. Route 22 in Pennsylvania: U.S. Route 22 (US 22) is an east–west route stretching from Cincinnati, Ohio in the west to Newark, New Jersey in the east.  In Pennsylvania, the route runs for 337.60 mi between the West Virginia state line at Washington County, where it is a limited-access expressway-grade route through the western suburbs of Pittsburgh, to the New Jersey state line at Easton.

Vermont Route 22A: Vermont Route 22A is a state highway in western Vermont, United States.  It is the northward continuation of New York State Route 22A.  Its southern end is at the New York state line in Fair Haven and its northern end is in Ferrisburgh at U.S. Route 7.  As it is an extension of NY 22A, VT 22A is a spur route of NY 22, which runs roughly parallel to VT 22A west of the state border.  This is a rather unusual case of one state having a suffixed route of another state's primary route.  Vermont does not currently have a "Route 22."

U.S. Route 22 in New Jersey: U.S. Route 22 (US 22) is a U.S. highway stretching from Cincinnati, Ohio in the west to Newark, New Jersey in the east.  In New Jersey, the route runs for 60.53 mi from the Easton-Phillipsburg Toll Bridge over the Delaware River in Phillipsburg, Warren County to Interstate 78 (I-78), US 1/9, and Route 21 at the Newark Airport Interchange in Newark, Essex County.  The road first heads through the Phillipsburg-Alpha area as a surface divided highway before running concurrent with I-78 through mountainous and agricultural sections of western New Jersey between Alpha and east of Clinton in Hunterdon County.  For the remainder of the route, US 22 runs to the south of I-78 through mostly suburban areas as a four- to six-lane surface divided highway, passing through Hunterdon, Somerset, Union, and Essex counties.  Along this portion, it intersects US 202 and US 206 in Somerville, I-287 in Bridgewater Township, and the Garden State Parkway in Union.

Water Street, Pennsylvania: Water Street is a small unincorporated village in the Canoe Valley of Morris Township, part of Huntingdon County, Pennsylvania, United States.  The Frankstown Branch Juniata River runs north along the west foot of the Tussey Mountain ridge to the village, before turning east along U.S. Route 22, crossing the ridge line through a water gap.  The intersection of U.S. Route 22 and PA Route 453 is located in the village.

Manjural Islam Rana: Rana made his first-class debut on 22 November 2000, playing for Khulna Division against Barisal Division.  His first wicket was that of Towhid Hossain, bowled, but he did not bat in the match.  In his next first-class match, against Dhaka Metropolis for Khulna, Rana batted for the first time; he scored 8 and 18 not out.  In the match, 19 other players made their first-class debut as this was the first match for both Khulna and Dhaka in Bangladesh's new National Cricket League.  Rana made his one-day debut the same month; on 25 November 2000, he played for Khulna against Barisal Division.  In the match he scored 22 runs and took 3 wickets for 20 runs.  Once again, Rana was one of 20 people to debut in the match in the new Ispahani Mirzapore Tea One-Day League.  In his first season with Khulna, Rana played 10 first-class matches, scoring 299 runs at 24.91 and taking 35 wickets at 20.14, and 10 one-day matches, scoring 70 runs at 11.66 and taking 10 wickets at 26.00.

New Jersey Route 173: Route 173 is a state highway in New Jersey, United States that is a designation for an old section of U.S. Route 22.  The route runs 14.62 mi from Interstate 78 and U.S. Route 22 in Greenwich Township, Warren County to County Route 626 (Beaver Avenue) in Clinton Township, Hunterdon County, just east of an interchange with Route 31.  Route 173 parallels Interstate 78 and U.S. Route 22 for its entire length through rural areas of Warren and Hunterdon Counties, passing through the towns of Bloomsbury and Clinton along the way.  At one point just to the west of Clinton, Route 173 runs concurrent with Interstate 78 and U.S. Route 22.

Art Kores: Arthur Emil "Art" Kores (July 22, 1886 – March 26, 1974) was a professional baseball player whose career spanned nine seasons, one of which was spent in Major League Baseball (MLB) with the St. Louis Terriers (1915).  In the majors, he compiled a .234 batting average with 18 runs scored, 47 hits, nine doubles, two triples, one home run, and 22 runs batted in (RBIs) in 60 games played.  He played all of his Major League games at third base.  Kores played the majority of his career in the minor leagues with the Des Moines Boosters (1911–1912), Portland Beavers (1913–1914), Rochester Hustlers (1915), Nashville Volunteers (1916–1917), Louisville Colonels (1918), Toledo Mud Hens (1920), and Indianapolis Indians (1920).  In the minors, he compiled a career .274 batting average with 1,225 hits, 212 doubles, 91 triples, and 29 home runs in 1,243 games played.  Kores batted and threw right-handed.  During his playing career, he stood at 5 ft and weighed 167 lb .

Edenburg, Pennsylvania: Edenburg is a census-designated place in Windsor Township, Berks County, Pennsylvania, United States.  It is located along Old Route 22, and very close to I-78 about 2 miles from Hamburg.  As of the 2010 census, the population was 681 residents.

Supporting paragraphs: Edenburg, Pennsylvania U.S. Route 22 in Pennsylvania
Answer: U.S. Route 22