Question: Werner Gunter Jaffé Fellner was born in which metropolis and the largest city in the German state of Hesse and the fifth-largest city in Germany?

Context paragraphs:
Werner Jaffé: Werner Gunter Jaffé Fellner (October 27, 1914 - May 3, 2009) was a chemist and university professor.  Jaffé was born in Frankfurt.  He received his doctoral degree at the University of Zurich under the supervision of the Nobel Prize winner Paul Karrer.  After graduating, Jaffé arrived in Venezuela in 1940 and became a professor at the Central University of Venezuela.  He started the teaching of Biochemistry at the Central University and founded the "Instituto Nacional de Nutrición".  He was cofounder of the Venezuelan Association for the Advancement of Science.  in 1946 he received a grant from the Rockefeller Foundation and, among several science prizes, he was awarded the "Premio Nacional de Ciencia , CONICIT" in 1978.  During the fifty years that he taught at the college level, he also published over 200 academic publications and was named honorary professor at the Simón Bolívar University.  He died in Caracas in 2009.

Middle Hesse: The region of Middle Hesse (German: "Region Mittelhessen" ) is one of three planning regions in the German state of Hesse, alongside North and South Hesse.  Its territory is identical with that of the administrative province of Gießen ("Regierungsbezirk Gießen") and covers the counties of Limburg-Weilburg, Lahn-Dill-Kreis, Gießen, Marburg-Biedenkopf and Vogelsbergkreis.  The Middle Hesse Regional Assembly ("Regionalversammlung Mittelhessen"), which decides on the regional plan, currently consists of 31 members chosen by the five counties and the three towns with special status: Gießen, Marburg and Wetzlar.  The regional assembly has tasked the governing president ("Regierungspräsident") with delivering regional management.  The Mid-Hesse Regional Management Association ("Regionalmanagementverein MitteHessen") was founded on 22 January 2003.

Volker Bouffier: Volker Bouffier (born 18 December 1951 in Giessen) is a German politician of the Christian Democratic Union (CDU).  Since 31 August 2010 he has been Minister President of the German state of Hesse.  From 1 November 2014 until 31 October 2015 he was President of the Bundesrat and "ex officio" deputy to the President of Germany.  He has been chairman of CDU in Hesse since July 2010.  From 1999 to 2010, he was minister of interior and sports in the state of Hesse.  Bouffier is a lawyer by profession.

East Hesse: East Hesse (German: "Osthessen" ) is a common but not unofficial regional name for the eastern part of the German state of Hesse as well as a regional planning region.  It corresponds roughly to the Hessian catchment area of Fulda and its heart covers the county of Fulda, the eastern part of the county of Vogelsbergkreis and the old counties of Hersfeld and Schlüchtern, but there is no clear boundary of East Hesse with North Hesse, Middle Hesse and South Hesse.  In older sources, a landscape, roughly identical with the current East Hesse area, was commonly called "Buchonia".

Frankfurt: Frankfurt, officially Frankfurt am Main (Literally "Frankfurt on the Main", ] ), is a metropolis and the largest city in the German state of Hesse and the fifth-largest city in Germany, with a 2015 population of 732,688 within its administrative boundaries, and 2.3 million in its urban area.  The city is at the centre of the larger Frankfurt Rhine-Main Metropolitan Region, which has a population of 5.5 million and is Germany's second-largest metropolitan region after Rhine-Ruhr.  Since the enlargement of the European Union in 2013, the geographic centre of the EU is about 40 km to the east of Frankfurt's CBD, the Bankenviertel.  Frankfurt is culturally and ethnically diverse, with around half of the population, and a majority of young people, having a migration background.  A quarter of the population are foreign nationals, including many expatriates.

West Hesse Depression: The West Hesse Depression (German: "Westhessische Senke" ) is part of the West Hesse Highlands and Lowlands region in the north of the German state of Hesse.  Like the East Hesse Depression, it is a series of separate depressions that form a natural corridor and have been an important historical trade route.

North Hesse: North Hesse (German: "Nordhessen" ) describes the northern part and historical heart of the German federal state of Hesse.  The region is – unlike the name Lower Hesse – not a historical territory and also has no established, standard and official administrative function.  However, the name is common and widely used today, not least to contrast it with its counterpart, South Hesse.  Over one million people live in North Hesse and its largest city is the former capital of the Electorate of Hesse, Kassel.

Bavaria: Bavaria ( German: "Bayern" ] ; Czech: "Bavorsko" ), officially the Free State of Bavaria (German: "Freistaat Bayern" ] ) is a landlocked federal state of Germany, occupying its southeastern corner.  With an area of 70,550.19 square kilometres (27,200 sq mi), Bavaria is the largest German state by land area.  Its territory comprises roughly a fifth of the total land area of Germany.  With 12.9 million inhabitants, it is Germany's second-most-populous state (after North Rhine-Westphalia).  Bavaria's capital and largest city, Munich, is the third largest city in Germany.

Hesse: Hesse ( or ) or Hessia (German: "Hessen" ] , Hessian dialect: "Hesse" ] ) is a federal state ("Land") of the Federal Republic of Germany, with just over six million inhabitants.  The state capital is Wiesbaden; the largest city is Frankfurt am Main.  Until the unification of Germany, the territory of Hesse was occupied by the Grand Duchy of Hesse, the Duchy of Nassau, the free city of Frankfurt and the Electorate of Hesse, known also as Hesse-Cassel.  Due to divisions after World War II, the modern federal state does not cover the entire cultural region of Hesse, which includes both the State of Hesse and the area known as Rhenish Hesse (Rheinhessen) in the neighbouring state of Rhineland-Palatinate.

List of Ministers-President of Hesse: The Minister-President of Hesse (German: "Ministerpräsident des Landes Hesse" ), also referred to as the Premier or Minister President (also translated into English as the Prime minister of Hessen), is the head of government of the German state of Hesse.  The position in its current form was created in 1946, when the provisional state of Greater Hesse was renamed.  Greater Hesse had been formed in 1945 after the Second World War from the Prussian Provinces of Kurhessen and Nassau (formed from the Prussian Province of Hesse-Nassau in 1944) and the People's State of Hesse.  The current Minister-President is Volker Bouffier, heading a coalition government between the Christian Democrats and the Greens.  Bouffier succeeded Roland Koch following his departure from active politics.

Supporting paragraphs: Werner Jaffé Frankfurt
Answer: Frankfurt