baber/WOPTO huggingface dataset:
Patent JP-2801228-B2 (JP)
IPC: C07K16/18
Filed: 1988-12-23
Granted: 1998-09-21
Abstract: Chimeric hosts are provided by introducing into an immunocompromised mammalian host xenogeneic, usually human, tissue under conditions where the xenogeneic tissue may both grow and interact, in such a way that undifferentiated ("stem") cells may be observed to differentiate and to proliferate. For example, tissues from hematopoietic organs are employed where tissue from different organs may be used which allow for differentiation and proliferation of the xenogeneic hematopoietic stem cells. Into SCID mice may be introduced fetal tissue, fetal liver tissue providing stem cells, thymus tissue, where the thymus grows into a competent thymus organ, and lymph node tissue, where the lymph node tissue grows into a competent lymph node, and the stem cells are processed to produce functional human B- and T-cells.
Patent JP-3585303-B2 (JP)
IPC: C12N5/12
Filed: 1995-11-20
Granted: 2004-11-04
Abstract: New humanized and chimeric monoclonal antibodies that recognize EGF-R and comprise an artificial sequence at least of the FRs of the heavy chain variable region of a human immunoglobulin. The hypervariable regions of both monoclonal antibodies is the following amino acid sequence: <IMAGE> Use of the antibodies for therapeutical and diagnostic purposes.
Patent JP-3561821-B2 (JP)
IPC: H01L23/31
Filed: 1995-12-01
Granted: 2004-09-02
Abstract: A semiconductor device having a photosensitive thermosetting resin layer 64 provided on top of a protective film 13 for a semiconductor chip 10. A lead frame 11 is affixed to the surface of this photosensitive thermosetting resin layer 64 only at support pin sections 60, 61, and this lead frame 11 is electrically connected to the surface of semiconductor chip 10. Breakage of the wiring and chip cracking are prevented after the pressure-bonding mounting of the lead frame. Because package cracking and package warping are better controlled in thermal processes such as such as IR reflow and resin sealing, a lower cost semiconductor device and manufacturing method are enabled.
Patent JP-2744743-B2 (JP)
Inventor: IZAWA HIKARU
IPC: G07D7/00
Filed: 1992-12-28
Granted: 1998-04-28
Abstract: Bank notes (14) are transferred by a conveyor (15) along a moving path, and an image sensor (17) disposed in the proximity of the moving path of the bank notes (14) converts the code printed on the bank notes (14) to electric signals. A printer (19) automatically prints out the read codes on the basis of the output of the image sensor. <IMAGE>
Patent JP-3449418-B2 (JP)
IPC: C12N15/85
Filed: 1992-05-29
Granted: 2003-09-22
Abstract: PCT No. PCT/US92/04469 Sec. 371 Date Jan. 28, 1994 Sec. 102(e) Date Jan. 28, 1994 PCT Filed May 29, 1992 PCT Pub. No. WO92/21763 PCT Pub. Date Dec. 10, 1992Methods are provided for the identification and use of endogenous nucleic acid sequences for homologous recombination and targeted integration of heterologous nucleic acid sequences. These methods are useful for introduction of nucleic acid into cells or tissue for gene therapy, or for the preparation of transgenic animals. Methods are also provided for enhancing the yield of genes of interest from recombinant cell culture lines.
Patent JP-3456992-B2 (JP)
IPC: C12N15/58
Filed: 1989-11-30
Granted: 2003-10-14
Abstract: Disclosed is a method of producing increased amounts of a protein of interest in a cell by induction. The method includes transfecting a cell with multiple copies of an expression vector, each copy of which includes an expressible gene encoding an enzymatically functional dihydrofolate reductase (DHFR) and an expressible gene encoding a protein of interest. Transfected cells are cultured in the presence of methotrexate (MTX) to produce a plurality of clones. A clone containing plural copy number of the vectors which co-express DHFR and the protein of interest is then selected and cultured. The cultured clone is treated with MTX to enhance the expression of the protein of interest by inducing an increase in transcription without substantially amplifying the genes encoding the protein of interest and DHFR.
Patent JP-4445042-B2 (JP)
IPC: C07D257/02
Filed: 1998-06-08
Granted: 2010-04-07
Abstract: A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the salts thereof of formula (I) which comprises the following steps: a) carboxymethylation reaction of a suitable precursor in water, with a haloacetic acid, b) hydrolysis reaction in basic conditions by addition of the base added at the previous step.
Patent JP-2612264-B2 (JP)
IPC: C12N15/10
Filed: 1986-04-03
Granted: 1997-05-21
Abstract: A DNA sequence consisting of a first DNA fragment containing the coding sequence for a desired polypeptide having N-amino acids, followed by the translation stop signal and if desired some untranslated bases which may comprise a restriction site, is coupled together with a second DNA fragment having the DNA structure necessary for replication of the cloning medium, at the last base after the N codon. This intermediate is useful for introduction into plasmids coding for a desired polypeptide.
Patent JP-H0638755-B2 (JP)
IPC: C12N1/20
Filed: 1984-05-24
Abstract: A process for the production of a fusion protein comprising an active portion of a chloramphenicol acetyltransferase (CAT) protein and a polypeptide. The fusion protein may be purified using CAT substrate affinity chromatography. The eucaryotic polypeptide may be calcitonin or a dervative thereof such as calcitonin-glycine. Other polypeptides described include enzymes such as chymosin, prochymosin and preprochymosin, hormones such as ACTH, insulins, and growth hormones and antigenic polypetides such as foot and mouth disease virus antigenic polypetide. The fusion protein may be cleaved at a site susceptible to selective enzymic or chemical cleavage to produce free polypeptide. The fusion protein may be used as an immunogen.
Patent JP-2977570-B2 (JP)
IPC: H03M7/40
Filed: 1989-02-17
Granted: 1999-11-15
Abstract: PCT No. PCT/ER89/00061 Sec. 371 Date Nov. 30, 1989 Sec. 102(e) Date Nov. 30, 1989 PCT Filed Feb. 17, 1989 PCT Pub. No. WO89/07863 PCT Pub. Date Aug. 24, 1989.A variable length encoding method for encoding a finite or infinite series of values corresponding to a random variable whose distribution monotonically decreases on either side of the mean value in which the encoding tree has a regular structure which is defined by an arithmetic and logic device. In order to encode each value E, a first binary word, including only bits having a same value and whose number of bits B is an increasing function of the value to the encoded E, is determined. The number of bits B is computed according to a predetermined arithmetic and logic function B(E). The method also involves determining a second binary word having a value to be encoded, in the set of values to be encoded arranged in order of decreasing probability, and whose number of bits B' is derived from the function B(E) and from the number of bits B in the first binary word. A code word is formed by combining the first and second binary words thus determined.
Patent JP-3203361-B2 (JP)
IPC: B01D29/13
Filed: 1996-06-27
Granted: 2001-08-27
Abstract: A fluid filter which comprises a canister having an open end and a closed end, the canister sealing to an adapter body to prevent leakage between the canister and the adapter body, the adapter body having a plurality of angled fluid inlet ports extending through the adapter assembly body into the cavity formed by the canister and the adapter body assembly, a threaded fluid outlet port extending through the adapter body, a threaded ring adapter for adapting the outlet port to a variety of filter receptacles, a multistage wire mesh filter element having a weave which is designed to prevent fluid contaminants from passing through the filter element while inhibiting the contaminant particles from becoming lodged in the filter mesh, the fluid inlet ports in the adapter body being formed at an angle to create a tornado type turbine fluid motion within the canister to suspend contaminants which are blocked from passage through the screen in the fluid and allow such contaminants to settle in the canister out of the flow path of fluid being filtered, a sediment chamber formed in the canister by a sediment trap, a relief valve assembly in the canister to allow fluid to bypass the filter element in the event the filter element becomes clogged, an anti-siphon valve in the fluid filter to prevent unfiltered fluid from being flushed from the filter, a switch for warning of a filter which needs to be removed and cleaned, and a magnetized drain plug to assist with contaminant removal from the fluid and allow the canister to be drained prior to removal to reduce injury and spillage.
Patent JP-2585778-B2 (JP)
IPC: G01D15/16
Filed: 1988-09-01
Granted: 1997-02-26
Abstract: In the embodiment of the hot melt ink supply unit described in the specification, a block (10) of solid hot melt ink has a peripheral surface formed with a key configuration (22) and a handle (14) is removably connected to the block by a threaded projection. After insertion of the block into a correspondingly keyed opening (24) in a heated reservoir (23), the handle is turned to separate the handle portion from the block of solid ink. A container provided with a removable seal encloses the block of solid ink and handle to protect the ink from contamination.
Patent JP-2954224-B2 (JP)
IPC: H04B7/08
Filed: 1988-10-28
Granted: 1999-09-27
Abstract: PCT No. PCT/EP88/00981 Sec. 371 Date Jun. 28, 1990 Sec. 102(e) Date Jun. 28, 1990 PCT Filed Oct. 28, 1988 PCT Pub. No. WO89/04092 PCT Pub. Date May 5, 1989.According to the receiving method for mobile reception has a plurality of individual receiving antennas, also known as diversity receiving method, on the individual antenna output signals an auxiliary modulation is superimposed and the antenna output signals are added to give a summation signal which as amplified selected intermediate-frequency summation signal is then demodulated in relation to amount and frequency or phase, the phase position of an individual signal in relation to the phase position of the summation signal and/or the amplitude contribution of an individual signal to the amplitude of the summation signal thereby being determined. This information is utilized for optimizing the useful signal with a view to optimum interference suppression for example in that the phases and/or amplitudes of the high-frequency individual signals are changed in dependence upon the phase position and/or amplitude contribution determined. With low circuitry expenditure this then gives a substantially improved reception quality in mobile systems. Receiving antenna systems for carrying out the method are described.
Patent JP-3417557-B2 (JP)
IPC: A61G10/00
Filed: 1992-04-17
Granted: 2003-06-16
Abstract: A chamber suitable for placing a subject under a pressure greater than atmospheric pressure with means for perfusing, cooling and respiring the subject. The chamber can be used in conjuction with low temperature surgical procedures.
Patent JP-3290179-B2 (JP)
IPC: C07D319/08
Filed: 1992-12-21
Granted: 2002-06-10
Abstract: PCT No. PCT/NL92/00234 Sec. 371 Date Jun. 17, 1994 Sec. 102(e) Date Jun. 17, 1994 PCT Filed Dec. 21, 1992 PCT Pub. No. WO93/13154 PCT Pub. Date Jul. 8, 1993.A copolymer of a lactone and a polycyclic carbonate is prepared by heating a monomer of a lactone with a polycyclic carbonate having two cyclic structures including a carbonate group at elevated temperatures less than 200 degrees Centigrade in the presence of a catalyst. The described copolymers evidence excellent mechanical properties, good resorption velocity and do not disintegrate upon degradation into materials of high crystallinity.
Patent JP-3115318-B2 (JP)
IPC: C07K14/535
Filed: 1990-08-14
Granted: 2000-12-04
Abstract: A fusion protein is disclosed which comprises GM-CSF and IL-3. Such fusion proteins more biologically active than GM-CSF or IL-3 alone or GM-CSF and IL-3 combined.
Patent JP-2974773-B2 (JP)
IPC: B65H18/20
Filed: 1991-08-16
Granted: 1999-11-10
Abstract: The known king roll reeling machines for shaftless winding of a web of material (4) divided by a lengthwise cut, in particular a web of paper of cardboard, onto sleeves (11) have take-up rollers (6) which are applied during take-up to two king rolls (2, 3) and are supported by guide heads (10) which can be inserted sideways into the sleeves of the two outer take-up rollers (6). The take-up rollers (6) can only be wound with high winding quality up to a maximum diameter. According to the invention, the space delimited by the king rolls (2, 3) and the take-up rollers (6) is sealed and an overpressure is produced in the space. To this end, sealing elements (18) which can be displaced axially to suit webs of different widths and which can be moved simultaneously in an area outside the area of movement of the guide heads (10) and their fastener (carriage (9)) are arranged in the region of the two side ends of the king rolls (2, 3). Frictional engagement between the king rolls is prevented when the sealing elements (15, 18) are in the sealing position.
Patent JP-3631499-B2 (JP)
IPC: C07C317/44
Filed: 1998-08-21
Granted: 2005-03-23
Abstract: Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use.
Patent JP-3609410-B2 (JP)
IPC: C07K14/475
Filed: 1994-11-14
Granted: 2005-01-12
Abstract: PCT No. PCT/SE94/01076 Sec. 371 Date Aug. 5, 1996 Sec. 102(e) Date Aug. 5, 1996 PCT Filed Nov. 14, 1994 PCT Pub. No. WO95/14034 PCT Pub. Date May 26, 1995Processes for refolding of insulin-like growth factor (IGF) comprise contacting IGF in a reduced or misfolded form with insulin-like growth factor binding protein (IGF-BP), and recovering native IGF.
Patent JP-2908878-B2 (JP)
IPC: C23C18/31
Filed: 1993-05-10
Granted: 1999-06-21
Abstract: PCT No. PCT/NO93/00073 Sec. 371 Date Nov. 15, 1994 Sec. 102(e) Date Nov. 15, 1994 PCT Filed May 10, 1993 PCT Pub. No. WO93/23588 PCT Pub. Date Nov. 25, 1993A method and an apparatus for coating tanks and pipe systems internally in that, first, a tank (1) is filled with a liquid (3) consisting of water to which is admixed an acid (10). Oxide coating on the internal surface is removed through heating and circulating the liquid (3) through a filter (4). The liquid (3) is neutralized through the admixture of a base (12). Approximately one fifth of the neutralized liquid (3) is drawn off, the tank (1) being refilled with a concentrated metal solution (15). The temperature, acidity and metal concentration of the liquid (3) are maintained close to constant through supplying heat, acid (10) or base or base (12), and concentrated metal solution (15), respectively. Air or vapor is supplied through a blowing pipe (5) and creates stirring, surplus liquid and gas being drained through a pipe (16). When the internal surface of the tank (1) has received a coating having the desired thickness, the process is interrupted in that the liquid (3) is cooled and drained.
Patent JP-2994753-B2 (JP)
IPC: B23F9/10
Filed: 1994-02-22
Granted: 1999-12-27
Abstract: Disclosed herein is a process for feeding a tool relative to a workpiece in a machining process such as a process for forming bevel and hypoid gears. The method comprises feeding the tool from an initial contact position with the workpiece to a full depth position in the workpiece along a feedpath at least a portion of which is defined by a feed vector having at least two feed vector components lying in an axial plane. The first feed vector component being substantially in the direction of the axis of a theoretical generating gear and the second feed vector component being substantially in a direction perpendicular to the generating gear axis. The feed vector may include a third feed vector component lying in a normal plane. With this feedpath undesirable tool shifting and workpiece spiral angle changes are significantly reduced.
Patent JP-3575804-B2 (JP)
IPC: H01M50/541
Filed: 1995-02-16
Granted: 2004-10-13
Abstract: PCT No. PCT/GB95/00323 Sec. 371 Date Sep. 19, 1995 Sec. 102(e) Date Sep. 19, 1995 PCT Filed Feb. 16, 1995 PCT Pub. No. WO95/22845 PCT Pub. Date Aug. 24, 1995This invention relates to apparatus for heating the lugs of battery plates. The apparatus 10 includes a hot air duct 11 which communicates with a nozzle 12 having a head 13 that defines a pair of opposite facing nozzles 14. Each nozzle 14 has an outlet 15 from which extends a generally flat and divergent plate 16. The plate 16 entrains hot air passing through the outlet 15 into a generally flat stream so that the hot air impinges on lugs 19, but not of the rest of the group 18 of plates and separators.
Patent JP-3639599-B2 (JP)
IPC: C12P41/00
Filed: 1996-12-05
Granted: 2005-04-20
Abstract: The disclosure relates to a process for obtaining optically active L- alpha -aminocarboxylic acids from the corresponding racemic D,L, alpha -aminocarboxylic acids. The following steps are involved: (a) the D,L, alpha -aminocarboxylic acids are acetylated; (b) the N-acetyl-L- alpha -aminocarboxylic acid present in the mixture of N-acetyl-D,L, alpha -aminocarboxylic acids thus obtained is broken down enzymatically into the L- alpha -aminocarboxylic acid; (c) the L- alpha -aminocarboxylic acid is separated from the mixture, a quantity of a solution with N-acetyl-D(L)- alpha -aminocarboxylic acids and a quantity of acetate equivalent to the L- alpha -aminocarboxylic acid being retained; and (d) the N-acetyl-D(L)- alpha -aminocarboxylic acid is racemised and recycled for enzymatic breakdown. Known extraction processes involving steps (a) to (d) have the disadvantage of producing large quantities of salts. Specifically, the processes are far removed from the ideal equation, according to which one hundred percent of the acetic anhydride and the D,L, alpha -aminocarboxylic acids are converted to L- alpha -aminocarboxylic acids and acetic acid. Adjusting the retained solution from step (c) in such a way as to obtain a solution consisting essentially of N-acetyl-D-(L)- alpha -aminocarboxylic acid salt and free acetic acid in equilibrium with acetate and free N-acetyl-D(L)- alpha -aminocarboxylic acid and from which acetic acid is extracted by distillation makes it surprisingly easy to feed the solution formed as "mother liquor" following separation of the L- alpha -aminocarboxylic acids in the circuit and to achieve a materials balance as close as possible to the ideal.
Patent JP-2931409-B2 (JP)
IPC: A61P43/00
Filed: 1995-02-27
Granted: 1999-08-09
Abstract: PCT No. PCT/EP95/00719 Sec. 371 Date Jun. 4, 1996 Sec. 102(e) Date Jun. 4, 1996 PCT Filed Feb. 27, 1995 PCT Pub. No. WO95/22974 PCT Pub. Date Aug. 31, 1995The present invention is concerned with a film coated tablet comprising as active ingredients the analgesic agent paracetamol and the antiemetic agent domperidone, and with a process of preparing such tablets.
Patent JP-4074338-B2 (JP)
IPC: A61K47/28
Filed: 1996-01-23
Granted: 2008-04-09
Abstract: Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.
Patent JP-3694029-B2 (JP)
IPC: G01J3/28
Filed: 1996-02-09
Granted: 2005-09-14
Abstract: PCT No. PCT/DK96/00068 Sec. 371 Date Apr. 3, 1996 Sec. 102(e) Date Apr. 3, 1996 PCT Filed Feb. 9, 1996 PCT Pub. No. WO96/24832 PCT Pub. Date Aug. 15, 1996A method for standardizing a spectrometer generating an optical spectrum from a sample, comprising generating at least one optical spectrum from at least one standardization sample each having a chemical composition resulting in the optical spectrum showing a characteristic pattern in a predetermined frequency range, comparing information relating to the pattern(s) to corresponding information relating to at least one reference pattern previously defined as the desired standard response from the at least one standardization sample, determining, based on the comparison, standardizing parameters describing the transition of the pattern(s) of the generated spectrum or spectra to the reference pattern(s) and storing said standardizing parameters in the spectrometer or a computer connected thereto, so that the spectrometer, when presented to an unknown sample, will, using the standardization parameters, generate an optical spectrum substantially identical to that which would be generated in a corresponding spectrometer standardized with a sample of the same chemical composition using the same previously defined reference pattern(s). The present method relates to standardization of the instrument to a well-defined state into which any number of instruments may be brought. In this state, calibrations may be transferred freely from instrument to instrument.
Patent JP-3174341-B2 (JP)
IPC: H01G9/02
Filed: 1994-04-15
Granted: 2001-06-11
Abstract: A process for producing capacitor grade powder, electrodes, and finished capacitors therefrom having reduced electrical leakage characteristics. The powder is prepared by reacting Group V-B base materials with quantities of between 500 to 7000 ppm of nitrogen and 700 to 3000 ppm of oxygen. Electrical leakage is reduced by at least 28% for electrodes anodized at 100 volts or greater in comparison with electrodes and finished capacitors made from undoped materials. A range of specific charge of up to 25,000 uFV/g is achieved for sintering temperatures of 1400 DEG  C. to 1800 DEG  C.
Patent JP-3914259-B2 (JP)
IPC: B01D15/02
Filed: 1996-03-26
Granted: 2007-05-16
Abstract: A continuous fluid-solid contacting apparatus, comprising: a plurality of chambers (20) for containing the solid, each chamber having a supply (22) and a discharge conduit (24) for the fluid; a rotatable frame (30) for supporting the chambers (20); means (34, 36) for rotating the frame about an axis of rotation (A); a single valve (40) for controlling a supply and discharge of at least one fluid to the chambers (20), characterized in that said valve comprises: an annular disk (50) having a planar surface forming a disk valve face (54) and a plurality of conduits (44, 46) formed in the disk, the conduits extending to the planar surface to form openings in the disk valve face, a rotatable annular plate (72) having a planar surface forming a plate valve face (74) and a plurality of holes (76) forming ports in the plate valve face, the plate valve face contacting the disk valve face, a plurality of supply and discharge pipes (80, 82) connected to the plate on a surface opposite the planar surface, each pipe communicating with one of said holes (76) and connected with one of a supply and discharge conduit (22, 24) of the chambers, means (112, 114, 115, 117) for rotating the annular plate (72) about the axis of rotation (A) of the frame (30). <IMAGE>
Patent JP-4011107-B2 (JP)
IPC: C07H19/16
Filed: 1995-04-13
Granted: 2007-11-21
Abstract: PCT No. PCT/EP94/01343 Sec. 371 Date Jan. 17, 1997 Sec. 102(e) Date Jan. 17, 1997 PCT Filed Apr. 13, 1995 PCT Pub. No. WO95/32212 PCT Pub. Date Nov. 30, 1995The invention relates to a process for the production of arabinonucleosides of general formula I   <IMAGE>   in which X represents a hydrogen atom or a fluorine atom, from triacetates of general formula II   <IMAGE>   in which X has the above-mentioned meaning, and the groups Ac respectively mean acetyl groups, which is characterized in that an esterase or lipase is caused to act on these compounds.
Patent JP-3846901-B2 (JP)
IPC: C07K14/28
Filed: 1996-05-16
Granted: 2006-11-15
Abstract: An oral dosage composition for intestinal delivery comprising (A) a biologically active ingredient; and (B) zonula occludens toxin, as well as a method for the use of the same.