Patent EP-1982717-A1 (EP)
Inventor: HAEUSER-HAHN DR ISOLDE
IPC: A61K31/4196
Filed: 2007-04-20
Abstract: Agent for treating mycosis in fishes and invertebrates and during their developmental stages, caused by fungus of the kind Saprolegnia, Achlya, Aphanomyces, comprises a fungicide, which is e.g. (A) inhibitors of the nucleic acid synthase e.g. benalaxyl; (B) inhibitors of mitosis and cell division e.g. benomyl; (C) inhibitors of the respiration; (D) decoupler e.g. dinocap; (E) inhibitors of the adenosine triphosphate production e.g. fentin acetate; and (F) inhibitors of the amino acid- and protein biosynthesis e.g. andoprim. Agent for treating mycosis in fishes and invertebrates and during their developmental stages, caused by fungus of the kind Saprolegnia, Achlya, Aphanomyces, comprises a fungicide, which is: e.g. (A) inhibitors of the nucleic acid synthesis e.g. benalaxyl, benalaxyl-M, bupirimate, clozylacon, dimethirimol, ethirimol, furalaxyl, hymexazol, mefenoxam, metalaxyl, metalaxyl-M, ofurace, oxadixyl, oxolinic acid; (B) inhibitors of mitosis and cell division e.g. benomyl, carbendazim, chlorfenazole, diethofencarb, ethaboxam, fuberidazole, pencycuron, profenofos, thiabendazole, thiophanate, thiophanate-methyl, zoxamide, 5-chloro-6-(2,4,6-trifluorophenyl)-7-(4-methylpiperidin-1-yl) [1, 2,4]triazolo[1,5-a]pyrimidine; (C) inhibitors of the respiration (respiratory chain inhibitors), which are (C1) inhibitors of the complex I of the respiratory chain e.g. diflumetorim, (C2) inhibitors of the complex II of the respiratory chain e.g. 2-chloro-N-(4'-prop-1-in-1-ylbiphenyl-2-yl)-nicotinamide, 2-chloro-N- [4'-(3,3-dimethylbut-1-in-1-yl)biphenyl-2-yl]-nicotinamide, 3-(difluoromethyl)-1-methyl- N-(4'-prop-1-yn-1-ylbiphenyl-2-yl)-1H-pyrazole-4-carboxamide, 3-(difluoromethyl)-N-[(9R)-9-isopropyl- 1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl]-1-methyl-1H-pyrazole-4-carboxamide, 3-(difluoromethyl)- N-[(9S)-9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1-methyl-1H-pyrazol-4-carboxamide, 3-(difluoromethyl)-N-[2-(3,3-dimethylbutyl)phenyl]-1-methyl-1H-pyrazol-4-carboxamide, 5-fluoro-1,3- dimethyl-N-(4'-prop-1-yn-1-ylbiphenyl-2-yl)-1H-pyrazole-4-carboxamide, N-[2-(1,3-dimethylbutyl) phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide, bixafen, boscalid, carboxin, fenfuram, fluopyram, flutolanil, furametpyr, furmecyclox, mepronil, N-[4'-(3,3-dimethylbut-1-in-1-yl)biphenyl-2-yl]-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide, N-[4'-(3,3-dimethylbut-1-in-1-yl)biphenyl-2-yl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide, N-{2-[1,1'-bi(cyclopropyl)-2-yl]phenyl}-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, oxycarboxin, penthiopyrad and thifluzamide; (D) decoupler e.g. dinocap, fluazinam, meptyldinocap; (E) inhibitors of the adenosine triphosphate production e.g. fentin acetate, fentin chloride, fentin hydroxide and silthiofam; (F) inhibitors of the amino acid- and protein biosynthesis e.g. andoprim, blasticidin-S, cyprodinil, kasugamycin, kasugamycin hydrochloride hydrate, mepanipyrim and pyrimethanil; (G) inhibitors of the signal transduction e.g. fenpiclonil, fludioxonil and quinoxyfen; (H) inhibitors of the lipid- and membrane-synthesis e.g. biphenyl, chlozolinate, edifenphos, etridiazole, iprobenfos, iprodione, isoprothiolane, procymidone, propamocarb, propamocarb hydrochloride, pyrazophos, tolclofos-methyl and vinclozolin; (I) inhibitors of the ergosterol-biosynthesis e.g. aldimorph, azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazole, difenoconazole, diniconazole, diniconazole-M, dodemorph, dodemorph acetate, epoxiconazole, etaconazole, fenarimol, fenbuconazole, fenhexamide, fenpropidin, fenpropimorph, fluquinconazole, flurprimidol, flusilazole, flutriafol, furconazole, furconazole-cis, hexaconazole, imazalil, imazalil sulfate, imibenconazole, ipconazole, metconazole, methyl 1-(2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazole-5-carboxylate, myclobutanil, naftifine, N-ethyl-N-methyl-N'-{2-methyl-5-(difluoromethyl)-4-[3-(trimethylsilyl)propoxy]phenyl}-imidoformamide, N-ethyl-N-methyl-N'-{2-methyl-5-(trifluoromethyl)-4-[3-(trimethylsilyl)propoxy]phenyl}-imido-formamide, nuarimol, oxpoconazole, O-{1-[(4-methoxyphenoxy)methyl]-2,2-dimethylpropyl}1H-imidazole-1-carbothioate, paclobutrazol, pefurazoate, penconazole, piperalin, prochloraz, propiconazole, prothioconazole, pyributicarb, pyrifenox, quinconazole, simeconazole, spiroxamine, tebuconazole, terbinafine, tetraconazole, triadimefon, triadimenol, tridemorph, triflumizole, triforine, triticonazole, uniconazole, viniconazole, voriconazole, 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol; (J) inhibitors of the cell wall synthesis e.g. benthiavalicarb, dimethomorph, flumorph, iprovalicarb, mandipropamid, N-[2-(4-{[3-(4-chlorphenyl)prop-2-yn-1-yl]oxy}-3-methoxyphenyl)ethyl]-N-2-(methylsulfonyl)valinamide, polyoxins, polyoxorim, validamycin A and valiphenal; (K) inhibitors of the melanine-biosynthesis e.g. carpropamid, diclocymet, fenoxanil, phthalide, pyroquilon and tricyclazole; (L) resistance inductors e.g. acibenzolar-S-methyl, probenazole and tiadinil. An independent claim is included for the prophylaxis and therapy of mycosis in fishes and invertebrates and their developmental stages, comprising treating fertilized egg, young adolescent fish and/or adult animals with the agent by mixing with water or fodder or by direct application. ACTIVITY : Fungicide. MECHANISM OF ACTION : None given.