Patent SG-11201811549U-A (SG)
Title: Boronic acid derivatives and therapeutic uses thereof
Inventor: HECKER SCOTT
IPC: A61K31/69
Filed: 2017-06-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 011111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/005662 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: Declarations under Rule 4.17: C07F 5/02 (2006.01) A61P 31/00 (2006.01) CO7F 5/04 (2006.01) A61P 31/04 (2006.01) — as to applicant's entitlement to apply for and be granted a A61K 31/69 (2006.01) patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the (21) International Application Number: earlier application (Rule 4.17(iii)) PCT/US2017/039787 Published: (22) International Filing Date: — with international search report (Art. 21(3)) 28 June 2017 (28.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/357,165 30 June 2016 (30.06.2016) US (71) Applicant: REMPEX PHARMACEUTICALS, INC. [US/US]; The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, CA 92121 (US). (72) Inventors: HECKER, Scott; 3033 Science Park Rd., Suite _ 200, San Diego, CA 92121 (US). REDDY, Raja K.; 3033 Science Park Rd., Suite 200, San Diego, CA 92121 (US). — GLINKA, Tomasz; 3033 Science Park Rd., Suite 200, San = Diego, CA 92121 (US). RODNY, Olga; 3033 Science Park Rd., Suite 200, San Diego, CA 92121 (US). = Agent: ALTMAN, Daniel E.; Knobbe, Martens, Olson & (74) = Bear, LLP, 2040 Main Street, 14th Floor, Irvine, CA 92614 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (81) = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = = KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, — MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = = Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, — GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — 1-1 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, k r ) N KM, ML, MR, NE, SN, TD, TG). 0 O_ 0 (54) Title: BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF 1-1 0 (57) : Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and ei preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, 13-lactamase C: inhibitors (BLIs).