baber/WOPTO huggingface dataset:
Patent WO-2020227575-A1 (WO)
Inventor: CLAGG KYLE BRADLEY PASCUAL
IPC: C07D487/04
Filed: 2020-05-07
Abstract: A method of synthesizing, comprising a step of making an imidazo-pyrimidine compound by coupling a first compound of formula (II) with a second compound of formula (III) Followed by a deprotection and tosylation step. The methods are able to produce an isotopically substituted molecule having upwards of 95% purity relative to non-isotopically substituted molecules. The invention further comprises compounds of formula:
Patent WO-2020242883-A1 (WO)
Inventor: HUANG HAN
IPC: H04N19/96
Filed: 2020-05-21
Abstract: Selon l'invention, un dispositif donné à titre d'exemple pour coder des données vidéo détermine, pour un premier bloc des données vidéo, s'il faut utiliser un mode de fusion de sous-bloc. S'il a été déterminé qu'il ne faut pas utiliser le mode de fusion de sous-bloc pour le premier bloc, le dispositif détermine s'il faut utiliser un mode de fusion avec mélange pour le premier bloc. S'il a été déterminé qu'il faut utiliser le mode de fusion avec mélange pour le premier bloc, le dispositif code le premier bloc avec le mode de fusion avec mélange.
Patent WO-2020243310-A1 (WO)
Title: Compositions and methods for thymic regeneration and t-cell reconstitution
Inventor: FINNEGAN PAUL
IPC: A61K35/12
Filed: 2020-05-28
Abstract: The present invention provides non-thymic endothelial cells (ntECs) engineered to express adenovirus E4ORF1 and/or BMP4, and compositions comprising such engineered ntECs. The present invention also provides methods of using such ntECs in therapy, for example to enhance thymic regeneration (including T cell reconstitution) in subjects in need thereof. Such subjects include those that have a damaged thymus, defective thymic function, insufficient T-cell output, and/or that are immunocompromised - for example as a result of ageing, infection (e.g. with HIV), treatment with radiation therapy, treatment with chemotherapy, or myeloablative conditioning in preparation for an organ/tissue transplant.
Patent WO-2021242260-A1 (WO)
Title: Densimètre à matériaux pour tube et élément de fixation différents
Inventor: LEBLANC MICHEL JOSEPH
IPC: G01N9/00
Filed: 2020-05-29
Abstract: Un densimètre selon la présente divulgation comprend un module de mesure qui est étalonné pour estimer la densité d'un fluide échantillon avec une grande précision et une sensibilité réduite à la température des composants formant le tube et l'élément de fixation dans le densimètre. Le densimètre mesure la densité du fluide échantillon en faisant vibrer le fluide échantillon et en mesurant la fréquence de résonance du fluide échantillon, puis en estimant la densité du fluide échantillon sur la base de cette fréquence de résonance. Le module de mesure est étalonné de façon spécifique en fonction de matériaux pour tube et élément de fixation différents. Le tube et l'élément de fixation du densimètre sont formés de matériaux qui sont choisis pour présenter un rapport coût/efficacité satisfaisant sur la base des spécifications du système de densimétrie et pour présenter des coefficients de dilatation thermique qui réduisent la dépendance à la température de la fréquence de résonance du fluide échantillon à l'intérieur du densimètre.
Patent WO-2020247614-A1 (WO)
Inventor: BLAIR JOHN
IPC: H04L29/06
Filed: 2020-06-04
Abstract: Various embodiments disclose a method for maintaining file versions in volatile memory. The method includes storing, in volatile memory for at least a first portion of a first sync interval, a first version of a file that is not modifiable during the at least the first portion of the first sync interval. The method also includes storing, in volatile memory for at least a second portion of the first sync interval, a second version of the file that is modifiable during the at least the second portion of the first sync interval. The method also includes subsequent to the first sync interval, replacing in nonvolatile memory, a third version of the file with the first version of the file stored in volatile memory. Further, the method includes marking the second version of the file as not modifiable during at least a first portion of a second sync interval.
Patent WO-2020252175-A1 (WO)
Inventor: GOLDMAN RADOSLAV
IPC: G01N27/62
Filed: 2020-06-11
Abstract: Provided is a sensitive and specific LC-MS-MRM quantification method that distinguishes outer-arm and core fucosylated configurations of N -glycopeptides. Advantage is taken of limited fragmentation of the glycopeptides at low collision energy (collision-induced dissociation) CID to produce linkage-specific Y-ions. These ions are selected as multiple reaction monitoring (MRM) transitions for the quantification of the outer-arm and total fucosylation of 23 glycoforms of 9 glycopeptides in 7 plasma proteins. The method permits quantification of the glycoforms directly in plasma or serum without fractionation of samples or glycopeptide enrichment. A pilot study of fucosylation in liver cirrhosis of hepatitis C virus (HCV) and non-alcoholic steatohepatitis (NASH) etiologies demonstrated that liver cirrhosis is consistently associated with increased outer-arm fucosylation of a majority of the analyzed proteins. The outer-arm fucosyaltion of the A2G2F1 glycoform of the VDKDLQSLEDILHQVENK peptide of fibrinogenwas found to increase more than 10-fold in the cirrhosis patients compared to healthy controls.
Patent WO-2020252396-A1 (WO)
Title: Compositions et procédés pour le traitement du virus respiratoire syncytial
Inventor: BORCHARDT ALLEN
IPC: A61K38/04
Filed: 2020-06-12
Abstract: Des compositions et des procédés pour le traitement d'infections virales comprennent des conjugués contenant des inhibiteurs de la protéine F du RSV virale (par exemple, presatovir, MDT 637, JNJ 179, ou un analogue de ceux-ci) liés à un monomère Fc, un domaine Fc et un peptide de liaison à Fc, une protéine d'albumine, ou un peptide de liaison à l'albumine. En particulier, les conjugués peuvent être utilisés dans le traitement d'infections virales (par exemple, des infections par le RSV).
Patent WO-2021007117-A1 (WO)
Inventor: ZHANG YU
IPC: G01S17/89
Filed: 2020-07-02
Abstract: According to an aspect of an embodiment, operations may comprise receiving sensor data from one or more vehicles, determining, by combining the received sensor data, a high definition map comprising a point cloud, and labeling one or more objects in the point cloud. The operations may also comprise generating training data by receiving a new image captured by one of the vehicles, receiving a pose of the vehicle when the new image was captured, determining an object having a label in the point cloud that is observable from the pose of the vehicle, determining a position of the object in the new image, and labeling the new image by assigning the label of the object to the new image, the labeled new image comprising the training data. The operations may also comprise training a deep learning model using the training data.
Patent WO-2021011458-A1 (WO)
Inventor: EMERY CHARLES D
IPC: A61B8/00
Filed: 2020-07-13
Abstract: Embodiments of a dermatological cosmetic treatment and/or imaging system and method adapted to alter placement and position of multiple (e.g., two or more) cosmetic treatment zones in tissue from ultrasound beams from a transducer, simultaneous multi-focus therapy at multiple depths, and/or dithering ultrasound beams from a transducer to alter placement and position of multiple cosmetic treatment zones in tissue. The system can include a hand wand, a removable transducer module, and a control module. In some embodiments, the cosmetic treatment system may be used in various cosmetic procedures.
Patent WO-2021016341-A1 (WO)
Title: Horizontal connector system and method
Inventor: SHIRANI ALIREZA
IPC: E21B43/013
Filed: 2020-07-22
Abstract: An apparatus includes a flowline connector having an inboard pipe and an outboard assembly. The outboard assembly includes a frame and an outboard pipe moveable within the frame to allow the outboard pipe to be moved toward the inboard pipe. The outboard assembly also includes a profile pipe in which the outboard pipe is received, and the profile pipe and the outboard pipe are connected to move together. The profile pipe includes at least one guide to change pitch or yaw of the outboard pipe to direct the outboard pipe toward alignment with the inboard pipe as the outboard pipe is moved within the frame toward the inboard pipe. Additional systems, devices, and methods are also disclosed.
Patent WO-2021021781-A1 (WO)
Inventor: ATENCIO DONALD
IPC: F16K3/02
Filed: 2020-07-28
Abstract: Improved apparatuses, systems, and methods for sealing a frac valve using pressurized fluid to drive one or more seal assemblies into sealing contact with a valve gate without substantial relative movement of the seal assembly components. In some embodiments, the improved apparatuses, systems, and methods provide a sealant to the face of the valve gate to ensure a fluid tight seal, a plurality of biased springs to ensure the seal assemblies are positioned properly to create a fluid tight seal, a shield to prevent fluids, particulates, and/or other materials from interfering with the operation of or damaging the seal assemblies, and/or a recess for receiving fluids, particulates, and/or other materials that would otherwise interfere with a fluid-tight seal or cause damage to the seal assemblies or valve gate.
Patent WO-2021025912-A1 (WO)
Title: Système et procédé pour éliminer le trioxyde de soufre contenu dans un gaz de combustion
Inventor: VITSE FREDERIC
IPC: B01D53/76
Filed: 2020-07-29
Abstract: L'invention concerne un système d'élimination de SO3 à partir d'un gaz de combustion. Le système comprend un conduit et un injecteur. Le conduit est opérationnel pour définir un chemin d'écoulement du gaz de combustion. L'injecteur est conçu pour injecter au moins une espèce contenant un alcali à l'état gazeux dans le conduit au niveau d'un point d'injection. La température du gaz de combustion au point d'injection est supérieure à la température de condensation de l'acide sulfurique.
Patent WO-2021080664-A1 (WO)
Title: Advanced lithium (li) ion and lithium sulfur (li s) batteries
Inventor: LANNING BRUCE
IPC: H01M4/38
Filed: 2020-07-31
Abstract: This disclosure provides a lithium (Li) ion battery that includes an anode, a cathode positioned opposite to the anode, a porous separator positioned between the anode and the cathode, and a liquid electrolyte in contact with the anode and the cathode. The anode includes an electrically conductive substrate. A first film is deposited on the electrically conductive substrate. The first film includes a first concentration of carbon particles in contact with each other and defines a first electrical conductivity for the first film. Each of the carbon particles includes a plurality of aggregates formed of few layer graphene sheets. The plurality of aggregates form a porous structure configured to undergo a lithiation, which can include any one or more of an intercalation operation or a plating operation. The anode and the cathode can include an electroactive material. The porous structure can provide conduction between the few layer graphene sheets.
Patent WO-2021076218-A1 (WO)
Inventor: WEINBERG ASSA
IPC: A61K31/4025
Filed: 2020-08-17
Abstract: Methods are provided to prevent and to treat fibromyalgia by using a vasodilator such as an angiotensin receptor blocker, ACE inhibitor, calcium channel blocker, phosphodiesterase inhibitor, alpha blocker, or beta blocker. More particularly, the methods do not employ orally administered vasodilators, but instead vasodilators that are administered through contact with the epidermis, e.g., in topical or other form suitable for contact with tissues to be treated. The compositions promote neo capillary formation, whereby symptoms of fibromyalgia are treated, reduced, or ameliorated.
Patent WO-2021046129-A1 (WO)
Title: Blockchain event processing database system
Inventor: KANG CHANGU
IPC: H04L29/06
Filed: 2020-09-02
Abstract: Provided herein is an event processing database system that stores the events in an easy-to-query database. The event processing systems herein are easily and securely scalable, employ the use of a flexible query language to filter a variety of event stream structures in various ways, and are capable of detecting combinations of multiple events.
Patent WO-2021050631-A1 (WO)
Inventor: REYNEKE RIAN
IPC: B01J8/24
Filed: 2020-09-10
Abstract: Un procédé dans lequel un mazout externe est utilisé pour laver un catalyseur entraîné à partir d'un effluent de réacteur de déshydrogénation de propane à lit fluidisé, le mélange de mazout et de catalyseur étant renvoyé au réacteur pour fournir le combustible net nécessaire à la régénération du catalyseur. Éventuellement, l'effluent de réacteur de déshydrogénation de propane à lit fluidisé et le mazout sont mis en contact dans un dispositif en ligne à contact direct avant d'entrer dans une zone de détente dans la cuve de réacteur.
Patent WO-2021067068-A1 (WO)
Inventor: ZHAO HANXIN
IPC: B25C1/00
Filed: 2020-09-22
Abstract: A fastener driving tool trigger assembly comprising: a bottom assembly (200) including: a pivotable trigger (210) rotatably attachable to a housing of a fastener driving tool, an actuation lever (230) attachable to the pivotable trigger, an actuation lever spring (250) attachable to the actuation lever to bias the actuation lever to a first position, a ramp (270) attachable to the pivotable trigger, and a damper mechanism (290) attachable to the actuation lever to control a rate of movement of the actuation lever; and a top assembly including: a top housing attachable to the housing of the fastener driving tool, and a downwardly extending block engageable with the actuation lever and the ramp to move the actuation lever to a second position different from the first position. A fastener driving tool comprising: a tool housing; a workpiece contact element; and said trigger assembly.
Patent WO-2021076287-A1 (WO)
Title: Semantic sweeping of metadata enriched service data
Inventor: ISAAK DONOVAN A
IPC: G06F16/906
Filed: 2020-09-24
Abstract: A system for detecting service issues within multi-sourced service data. The system includes a memory and one or more electronic processors coupled to the memory. The electronic processors are configured to receive one or more data sets in near real time, and to enrich the dataset with one or more metadata parameters, pre-clean the data within the dataset, and determine one or more data points within the dataset that are semantically similar to each other. The electronic processors are also configured to generate a similarity score for each of the semantically similar data points, and determine one or more significant clusters within the dataset within a predefined lookback window. The electronic processors are also configured to analyze the determined significant clusters to determine the existence of one or more service issues, and generate a service alert based on the analysis determining that one or more service issues are present.
Patent WO-2021071934-A1 (WO)
Inventor: QIN WEIPING
IPC: A61K31/573
Filed: 2020-10-07
Abstract: Sont divulgués ici, des conjugués de méthylprednisolone polymères et des promédicaments ainsi que leur procédé d'utilisation. Sont divulguées ici, des méthodes de traitement d'une lésion de la moelle épinière chez un sujet, consistant : à administrer de manière systémique une composition comprenant un conjugué de méthylprednisolone polymère au sujet. Sont divulgués ici, des procédés d'amélioration de la neuroprotection chez un sujet après une lésion de la moelle épinière, consistant à administrer de manière une composition comprenant un conjugué de méthylprednisolone polymère au sujet.
Patent WO-2021086694-A1 (WO)
Title: Drive module with improved efficiency
Inventor: BRADFIELD MICHAEL
IPC: H02K9/19
Filed: 2020-10-21
Abstract: A drive module (20) for a vehicle (10) including an electric machine (24), an inverter (22), a gearing assembly (26), and a cooling system. A first housing member (50) thermally coupled with the inverter has a first set of heat exchange surfaces (52) and a second housing member (40) thermally coupled with the electric machine has a second set of heat exchange surfaces (42). The first and second sets of heat exchange surfaces each project into an interior volume (44) cooled by an externally supplied liquid coolant which thereby defines a heat exchanger. A lower oil sump (54) for collecting oil used to cool the electric machine may also include heat exchange surfaces (56) projecting into the same heat exchanger. The gearbox may include an elevated oil sump (84) which is supplied by the same oil pump circulating oil on the electric machine wherein the elevated oil sump gravity feeds oil onto selected surfaces within the gearbox. A solenoid activated valve assembly (78) can be employed with a variable capacity oil pump (76) to independently vary the supply of oil to two different applications.
Patent WO-2021101714-A1 (WO)
Inventor: THOMPSON JONATHAN
IPC: A61F5/00
Filed: 2020-11-04
Abstract: Disclosed are embodiments of an apparatus (102), system (10), and method for performing a sleeve gastrectomy. The apparatus (102) can include a bougie (105) for insertion into an interior of a stomach (12), the bougie (105) having a proximal bougie end (106) and a distal bougie end (108), an inflation lumen (120) having a proximal lumen end (124) and a distal lumen end (122), the inflation lumen (120) extending from the proximal bougie end (106) through the distal bougie end (108), a fluid delivery system (134, 136) coupled with the proximal lumen end (124), the fluid delivery system (134, 136) being operably configured to deliver positive pressure in a predetermined positive pressure range into the stomach (12), and a monitor (402) coupled with the proximal lumen end (124) operably configured for the monitoring of pressure or volume within the stomach (12). The bougie (105) can be operably configured to define a resection line for the sleeve gastrectomy when the predetermined positive pressure range is achieved within the stomach (12).
Patent WO-2021092577-A1 (WO)
Inventor: KENDERIAN SAAD J
IPC: C07K14/705
Filed: 2020-11-09
Abstract: Ce document concerne des procédés et des matériels intervenant dans le traitement d'un mammifère (par exemple, un être humain) ayant, ou présentant un risque de développer, une maladie ou un état caractérisé par une inflammation et/ou une dégénérescence d'un tissu. Par exemple, l'invention concerne des cellules souches mésenchymateuses (MSC) exprimant un récepteur d'antigène (par exemple, un récepteur d'antigène chimère) ciblant un tissu qui peut exercer un effet immunosuppresseur dans le tissu ciblé, ainsi que des procédés d'utilisation de ces MSC.
Patent WO-2021108209-A1 (WO)
Title: Biocatalyseurs et procédés d'hydroxylation de composés chimiques
Inventor: VROOM JONATHAN
IPC: C12N5/00
Filed: 2020-11-19
Abstract: La présente invention concerne des polypeptides de proline hydroxylase modifiés pour la production de composés hydroxylés, des polynucléotides codant pour les proline hydroxylases modifiées, des cellules hôtes capables d'exprimer les proline hydroxylases modifiées, et des procédés d'utilisation des proline hydroxylases modifiées pour préparer des composés utiles dans la production d'agents pharmaceutiques actifs.
Patent WO-2021113094-A1 (WO)
Title: Method and apparatus for transitioning between electromagnetic wave modes
Inventor: HENRY PAUL SHALA
IPC: H04B3/06
Filed: 2020-11-20
Abstract: Aspects of the subject disclosure may include, a system that facilitates detecting first electromagnetic waves propagating along a transmission medium are experiencing a first propagation loss, inducing second electromagnetic waves along the transmission medium to mitigate the first propagation loss, detecting that the second electromagnetic waves are experiencing a second propagation loss and inducing third electromagnetic waves along the transmission medium to mitigate the second propagation loss. To reduce radiation losses when transitioning from the first electromagnetic waves to second electromagnetic waves and transitioning from the second electromagnetic waves to the third electromagnetic waves, the system can be further adapted to use differing criteria for each transition. Other embodiments are disclosed.
Patent WO-2021145970-A1 (WO)
Title: Delay circuit that accurately maintains input duty cycle
Inventor: CHAKKIRALA SUBBARAO SURENDRA
IPC: H03K5/133
Filed: 2020-12-04
Abstract: In certain aspects, a delay circuit includes a multiplexer, a first delay path coupled between an input of the delay circuit and a first input of the multiplexer, and a second delay path coupled between the input of the delay circuit and a second input of the multiplexer. The first delay path includes a first delay device, and the second delay path includes a first inverter, a second delay device, and a second inverter. In other aspects, a delay circuit includes a latch including a first input, a second input, and an output. The first input of the latch is coupled to an input of the delay circuit. The delay circuit also includes a delay path coupled between the input of the delay circuit and the second input of the latch, wherein the delay path includes a pulse generator and a delay device.
Patent WO-2022139791-A1 (WO)
Inventor: SANKARAGOMATHI KANNAN
IPC: H03M1/00
Filed: 2020-12-21
Abstract: This disclosure describes apparatuses, methods, and techniques that enable a computing device to support a dynamic range of audio quality, varying bandwidths, varying sampling rates, numerous effective number of bits (ENOBs) resolutions, conserve power during an overall usage of the computing device, and enhance a user experience. To do so, the computing device utilizes a reconfigurable analog-to-digital converter (ADC). The reconfigurable ADC includes a successive-approximation-register (SAR) ADC, a noise-canceling circuit, and a noise-shaping circuit. The reconfigurable ADC can selectively operate in different modes of operation, in part, by enabling or disabling the noise-canceling circuit and the noise-shaping circuit.
Patent WO-2022010531-A1 (WO)
Title: Efficient update of cumulative distribution functions for image compression
Inventor: MASSIMINO PASCAL
IPC: H03M7/40
Filed: 2020-07-06
Abstract: Updating cumulative distribution functions (CDFs) during arithmetic encoding can be a challenge because the final element of the CDF should remain fixed during the update calculations. If the probabilities were floating-point numbers, this would not be too much of a challenge; nevertheless, the probabilities and hence the CDFs are represented as integers to take advantage of infinite-precision arithmetic. Some of these difficulties may be alleviated by introducing a "mixing" CDF along with the active CDF being updated; the mixing CDF provides nonlocal context for updating the CDF due to the introduction of a particular symbol in the encoding. Improved techniques of performing arithmetic encoding include updating the CDF using two, one-dimensional mixing CDF arrays: a symbol-dependent array and a symbol-dependent array. The symbol-dependent array is a sub array of a larger, fixed array such that the sub array selected depends on the symbol being used.