baber/WOPTO huggingface dataset:
Patent WO-2020097376-A1 (WO)
Inventor: KARVE SHIRANG
IPC: C08G65/333
Filed: 2019-11-07
Abstract: The compounds disclosed herein (e.g., compounds of Formula (I), (II), (III), and (IV)) comprise a lipid substructure comprising a hydrophobic moiety and a hydrophilic moiety; and two or more polymeric groups (e.g., two or more polyethylene glycol (PEG) groups). The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
Patent WO-2020102214-A1 (WO)
Inventor: LOCKE CHRISTOPHER
IPC: A61F13/00
Filed: 2019-11-12
Abstract: Systems, apparatuses, and methods for providing negative pressure to a tissue site are disclosed. Illustrative embodiments may include an apparatus or system for delivering negative-pressure to a tissue site, which can be used in conjunction with low-profile distribution components for wound therapy. Such apparatus may include a low-profile dressing interface or connector comprising at least two fluid pathways fluidly coupled to a recessed space of the connector, one for providing negative pressure to a tissue interface or manifold and the other for sensing the negative pressure within the recessed space adjacent the tissue interface. In some embodiments, a pressure-offloading layer may be disposed against at least one of the fluid pathways. The pressure-offloading layer may comprise a polymeric foam to distribute compressive forces being applied to the dressing interface, thereby enhancing resistance of the fluid pathways to collapsing and blockage when the dressing interface is subject to external compression. In some embodiments, two pressure-offloading layers may be utilized.
Patent WO-2020102369-A1 (WO)
Inventor: KONDRAGUNTA BHARGAVI
IPC: C12N9/48
Filed: 2019-11-13
Abstract: L'invention concerne des procédés et des compositions pour le traitement de la maladie de Batten. De telles compositions comprennent un virus adéno-associé recombinant (VAAr), ledit VAAr comprenant une capside de virus adéno-associé (VAA), et un génome vectoriel encapsidé dans celle-ci, ledit génome vectoriel comprenant (a) une séquence terminale inversée répétée (ITR) de VAA 5'; (b) un promoteur; (c) une séquence de codage de CLN2 codant pour un TPP1 humain; (d) une ITR de VAA 3'. L'invention concerne également des méthodes de traitement de la maladie de Batten comprenant l'administration à un sujet, ayant besoin d'un tel traitement, dudit VAAr par l'intermédiaire de plus d'une voie. L'invention concerne également des compositions pharmaceutiques comprenant le dit VAAr et des méthodes associées de traitement de la maladie de Batten.
Patent WO-2020102494-A1 (WO)
Title: Nanoemulsion compositions having enhanced permeability
Inventor: CIOTTI SUSAN
IPC: A61K9/00
Filed: 2019-11-14
Abstract: The present disclosure relates to nanoemulsion compositions with certain surfactant blend ratios that impart enhanced permeability. Such compositions are useful for topical, mucosal, vaginal, and intranasal applications and allow for the greater delivery of one or more active agents to the application site.
Patent WO-2020118181-A1 (WO)
Title: Method and apparatus for manufacturing microtablets
Inventor: IMRAN MIR A
IPC: A61K9/20
Filed: 2019-12-06
Abstract: Embodiments provide methods and apparatus for manufacturing a microtablet from a precursor material such as a pharmaceutical powder. Various embodiments provide a method which includes compressing the powder to form a compressed mass of a selected density and repeatedly compacting the compressed mass to increase the density of the compressed mass and form a microtablet. Related methods and apparatus are provided.
Patent WO-2020123353-A1 (WO)
Title: Système de communication visuelle
Inventor: SHEPARD RALPH
IPC: B60Q1/50
Filed: 2019-12-09
Abstract: La présente invention concerne un système de messagerie monté sur affichage. Le système de messagerie monté sur affichage peut comprendre un affichage à diodes électroluminescentes (DEL) fixé à un boîtier (110) d'un capteur (301). Le boîtier du capteur peut tourner. Le système de messagerie monté sur affichage peut également comprendre un dispositif de commande de DEL (660) configuré pour activer et pour désactiver sélectivement au moins une DEL (901 à 903, 820) sur l'affichage à DEL, pour fournir un message (550, 650) en direction d'un destinataire visé (840, 940).
Patent WO-2020123954-A1 (WO)
Inventor: KABRAMS ERIC
IPC: A61B5/375
Filed: 2019-12-13
Abstract: Selon certains aspects, un dispositif de la présente invention comprend un capteur configuré pour détecter un signal provenant du cerveau de la personne et un premier processeur en communication avec le capteur. Le premier processeur est programmé pour identifier un état de santé et, sur la base de l'état de santé identifié, fournir des données du signal à un second processeur à l'extérieur du dispositif pour corroborer ou contredire l'état de santé identifié.
Patent WO-2020132088-A1 (WO)
Title: Methods and systems for radio waved based health monitoring that utilize amplitude and phase data
Inventor: LEABMAN MICHAEL A
IPC: A61B5/113
Filed: 2019-12-18
Abstract: A method for monitoring a health parameter in a person is disclosed. The method involves transmitting radio waves below the skin surface of a person and across a range of stepped frequencies, receiving radio waves on a two-dimensional array of receive antennas, the received radio waves including a reflected portion of the transmitted radio waves across the range of stepped frequencies, generating data that corresponds to the received radio waves, wherein the data includes amplitude and phase data, and determining a value that is indicative of a health parameter in the person in response to the amplitude and phase data.
Patent WO-2020150107-A1 (WO)
Inventor: ALLEN JOSEPHINE
IPC: C12M1/40
Filed: 2020-01-10
Abstract: Chambres de bioréacteur et systèmes associés. Dans un mode de réalisation, l'invention concerne une chambre de bioréacteur symétrique à plaque unique, comprenant un canal d'écoulement s'étendant le long d'un premier axe, le canal d'écoulement possédant une entrée et une sortie aux extrémités opposées du canal d'écoulement; une paire d'entretoises sur des extrémités opposées d'un second axe, le second axe étant sensiblement perpendiculaire au premier axe, chaque entretoise de la paire d'entretoises étant placée sur des côtés opposés du canal d'écoulement, les entretoises étant configurées pour être couplées à un actionneur linéaire bidirectionnel et configurées pour exercer une contrainte perpendiculaire à un écoulement de fluide à travers le canal d'écoulement, la contrainte ne déplaçant pas latéralement les cellules présentes dans le canal d'écoulement.
Patent WO-2020171967-A1 (WO)
Inventor: DEJNEKA MATTHEW JOHN
IPC: C03C3/091
Filed: 2020-02-06
Abstract: L'invention concerne une vitrocéramique qui comprend : du SiO 2  de 40 % en moles à 80 % en moles ; de l'Al 2 O 3  de 3 % en moles à 20 % en moles ; du B 2 O 3  de 3 % en moles à 50 % en moles ; du WO 3  plus MoO 3  de 1 % en moles à 18 % en moles ; du Fe 2 O 3  plus MnO 2  de 0,1 % en moles à 2 % en moles ; et du R 2 O de 0 % en moles à 15 % en moles. Le R 2 O est un ou plusieurs des Li 2 O, Na 2 O, K 2 O, Rb 2 O et Cs 2 O. En outre, les R 2 O - Al 2 O 3  se trouve dans la plage de -12 % en moles à +4 % en moles.
Patent WO-2020176454-A1 (WO)
Inventor: PATIL DADASAHEB V
IPC: C08L79/08
Filed: 2020-02-25
Abstract: A polyimide composition, comprising a functionalized polyimide prepared from a substituted or unsubstituted C 4-40  bisanhydride; a substituted or unsubstituted C 1-40  organic diamine; and optionally an organic compound comprising at least two functional groups per molecule, wherein a first functional group is reactive with an anhydride group, an amine group, or a combination thereof, and the first functional group is different from a second functional group, wherein the functionalized polyimide comprises a reactive end group of the formula (C 1-40  hydrocarbylene)-NH 2 , (C 1-40  hydrocarbylene)-OH, (C 1-40  hydrocarbylene)-SH, (C 4-40  hydrocarbylene)-G, or a combination thereof, wherein G is an anhydride group, a carboxylic acid, a carboxylic ester, or a combination thereof, wherein the functionalized polyimide has a total reactive end group concentration of 50-1,500 μeq/g of the functionalized polyimide, and wherein the polyimide composition has 0.05-1,000 ppm of residual organic diamine, wherein the functionalized polyimide is obtained by precipitation from a solution using an organic anti-solvent or by devolatilization.
Patent WO-2020176532-A1 (WO)
Title: Method and apparatus for time-domain crosstalk cancellation in spatial audio
Inventor: LIKAMWA ROBERT
IPC: H04S1/00
Filed: 2020-02-25
Abstract: A system to output a cross-talk cancelled spatial audio signal to two speakers, including a user tracking module to provide a location and orientation of a head of a user, and a time-domain dynamic crosstalk cancellation module to receive a spatial audio signal, the location and orientation of the head of the user from the user tracking module, a location for each of the two speakers, and generate the time-domain crosstalk cancelled spatial audio signal based thereon.
Patent WO-2020180987-A1 (WO)
Title: Autonomous management of a diabetic condition based on mealtime and activity detection
Inventor: Mears mark
IPC: G16H50/30
Filed: 2020-03-04
Abstract: Management of a diabetic condition may be performed by detecting a mealtime and/or an increased level of activity associated with a user. The mealtime is detected based one or more mealtime indicators that may indicate a likelihood of an occurrence of a mealtime. Each mealtime indicator provides additional context around the likelihood of a mealtime. To assist in managing the diabetic condition, a user's elevated activity levels may be detected. The activity level of a user is detected based on one or more activity indicators. Each activity indicator provides additional context around the likelihood of an increased level of activity by the user. Management of the diabetic condition may be performed proximate a mealtime or a user exercising to increase the efficacy of management of the diabetic condition.
Patent WO-2020205204-A1 (WO)
Inventor: OKRONGLY DAVID
IPC: G01N33/574
Filed: 2020-03-13
Abstract: Aspects of the disclosure relate to methods and systems for detecting prostate cancer and/or evaluating a subject for a prostate biopsy. In some embodiments, a subject may undergo an assessment to determine the likelihood of prostate cancer. For instance, one or more immunoassay may be performed on a blood sample of the subject to determine biomarker levels that may be used with certain clinical factors to determine a likelihood score for aggressive prostate cancer. A subject having a likelihood score within a threshold range may undergo a second assessment to determine the likelihood of prostate cancer. For example, the subject may undergo an imaging technique to detect prostate cancer. The outcome of the second assessment may be used to determine the likelihood of aggressive prostate cancer and/or biopsy recommendation. Methods and systems, described herein, may be particularly well-suited for the minimally invasive and cost-effective detection of prostate cancer in subjects.
Patent WO-2020190829-A1 (WO)
Title: Method of dialysis of blood
Inventor: TIMKO JOHN WILLIAM
IPC: A61M39/20
Filed: 2020-03-16
Abstract: The present disclosure provides a method for hemodialysis of blood, comprising providing a hemodialysis catheter having a low recirculation distal tip, a first and a second extension tubes that are configured to be connected to a dialysis machine, providing a hemodialysis machine with an arterial patient connector and a venous patient connector; conducting hemodialysis with the first extension tube connects to the arterial patient connector of the dialysis machine, and the second extension tube connects to the venous patient connector of the dialysis machine; and periodically reversing the first and second extension tubes connections to the arterial and venous patient connectors of the dialysis machine in a subsequent hemodialysis. The present disclosure also provides a hemodialysis catheter, comprising a switchable connection indicator indicating connection to arterial or venous flow path. The switchable connection indicator can be integrated with a clamp.
Patent WO-2020191237-A1 (WO)
Title: Dual activity super toxic rnai active dsrnas
Inventor: PETER MARCUS
IPC: C12N15/63
Filed: 2020-03-19
Abstract: Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called "death-induced by survival gene elimination" or "DISE." The disclosed toxic RNAi active seed sequences may be referred to as "dual activity super toxic RNAi active dsRNAs" that include a toxic first strand and a toxic second strand that is complementary to the toxic first strand. As such, the disclosed dsRNAs may be expressed as shRNAs which are processed for RNA interference (RNAi) and either of the toxic first strand and the toxic second strand can function as a guide strand to initiate RNAi.
Patent WO-2020198235-A1 (WO)
Title: Mounting configurations for optoelectronic components in lidar systems
Inventor: MCCORD MARK ARMSTRONG
IPC: G01S7/481
Filed: 2020-03-24
Abstract: A LiDAR system includes a first optical lens, and one or more first optoelectronic packages spaced apart from the first optical lens along the optical axis of the first optical lens. Each respective first optoelectronic package includes a first plurality of optoelectronic components positioned on the respective first optoelectronic package such that a surface of each respective optoelectronic component lies substantially on the first surface of best focus. The LiDAR system further includes a second optical lens, and one or more second optoelectronic packages spaced apart from the second optical lens along the optical axis of the second optical lens. Each respective second optoelectronic package includes a second plurality of optoelectronic components positioned on the respective second optoelectronic package such that a surface of each respective optoelectronic component lies substantially on the second surface of best focus.
Patent WO-2020214414-A1 (WO)
Title: Iron detection and remediation with a functionalized porous polymer
Inventor: LEE SUMIN
IPC: B01J20/22
Filed: 2020-03-31
Abstract: Ether-thioether functionalized porous aromatic framework (RAF) polymers provide high selectivity for iron(ll) and iron(lll) adsorption in aqueous samples. The material described in this invention can be used to remove potentially toxic iron from contaminated waters with high efficiency and selectivity in the presence of many other common competing species. Thus, this invention is useful to produce materials for water treatment applications, in addition to remove iron from water.
Patent WO-2021201856-A1 (WO)
Inventor: ARAFAT AKM
IPC: H02P29/50
Filed: 2020-04-01
Abstract: A method for operating a motor control system to dynamically compensate for low-frequency and/or high-frequency torque ripple. Embodiments include receiving an input command, receiving drive feedback signals representative of drive currents in a motor, identifying harmonics in the drive feedback signals representative of motor torque ripple, producing torque ripple compensation signals based on the identified harmonics; and producing motor drive control signals based on the input command, the current feedback signals,the torque ripple compensation signals, and carrier signals with a certain phase shift.
Patent WO-2020206094-A1 (WO)
Title: Source independent consistent tokenization
Inventor: ROYYURU VIJAY
IPC: G06Q20/00
Filed: 2020-04-02
Abstract: A gateway encryption service is used to ensure consistent, source independent tokenization for payment accounts and synchronizing payment account information with merchants. A consistent, evergreen merchant-facing token is generated and used for each payment account for the merchant, ensuring that regardless of the payment method used by the customer (e.g., plastic card point-of-sale, pay wallet, saved card information) for the same underlying account, the merchant has a single token. Further, if the account number for the underlying payment account changes (e.g., the card expires or is stolen) the merchant-facing token remains consistent. The evergreen token ensures that the system functions more efficiently, saving resources in processing and storage and ensuring less network traffic for failed transactions. The system further implements encryption and security despite the consistent tokenization, further saving resources.
Patent WO-2020219262-A1 (WO)
Title: Fixturing system for woodworking
Inventor: PUGH DENNIS
IPC: F16B39/00
Filed: 2020-04-07
Abstract: A fixturing system for woodworking includes a woodworking table having a planar top surface and a T-slot. The T-slot has a central section that is open at the top surface, and further has a pair of undercut sections projecting laterally from opposite sides of the central section. A pair of inner surfaces face downward over the pair of undercut sections of the T-slot. The system further includes a T-nut. An upper portion of the T-nut is receivable in the central section of the T-slot, and has a screw-threaded bore. The bore has a nominal cross-sectional area for receiving a screw-threaded shank on a fastener. A lower portion of the T-nut has a pair of clamping surfaces projecting laterally from opposite sides of the upper portion. The clamping surfaces on the T-nut have a combined surface area of at least about 4 times the nominal cross-sectional area of the bore.
Patent WO-2020236345-A1 (WO)
Inventor: GERGES HANY GREES
IPC: G06F8/41
Filed: 2020-04-15
Abstract: The present disclosure relates to systems and methods that are configured to semi-automate data transformation processing so that content can be transformed, from one type of electronic document, for presentation in another type of electronic document. For instance, data transformation suggestions, for transforming content from a first form into a presentation form (second form), may be generated and presented to a user through an improved user interface of an application/service that is used to display the first form of the content. The improved user interface provides a new user interface menu to manage the data transformation suggestions and/or export/import processing of data from one type of electronic document to another. Based on user selection of the confirming data transformation suggestions through the user interface menu, a presentation document is automatically generated on behalf of the user, for example, in a different application/service.
Patent WO-2020215070-A1 (WO)
Inventor: LOTSPEICH ERIK
IPC: G06F21/00
Filed: 2020-04-20
Abstract: Systems and methods of cyber hardening software by modifying one or more assembly source files. In some embodiments, the disclosed SME tool transparently and seamlessly integrates into the build process of the assembly source files being modified. For example, upon integration of the disclosed SME tool into the application's development environment, the modifications in the final executable are transparent to the developer and can support other cyber hardening techniques. The SME tool includes a preprocessing tool for identifying attributes (e.g., functions) associated with the assembly source file. The SME tool also includes a transformation tool for making modifications of the assembly source file. In some embodiments, the transformations correspond to applying one or more transformations to the attributes associated with the assembly source file.
Patent WO-2020223595-A1 (WO)
Title: Structure-guided engineering of peptide-based nlrp3 inflammasome inhibitors for myelodysplastic syndromes (mds)
Inventor: LIST ALAN
IPC: C07K14/47
Filed: 2020-05-01
Abstract: Disclosed are compositions and methods for engineered peptide inhibitors of NLRP3 infiammasome and methods of their use in the treatment of Myelodysplastic Syndromes. In one aspect, disclosed herein are engineered inhibitors of NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome comprising a Helix 2 of POP1 comprising one or more substitutions at residues 18, 21, 22, 25, 26, 28, 29, and/or 30 of POP1 as set forth in SEQ ID NO:1.
Patent WO-2020227413-A1 (WO)
Title: Dispositif de détection d'organophosphates
Inventor: ROSENBERG YVONNE
IPC: G01N33/00
Filed: 2020-05-06
Abstract: La présente invention concerne un dispositif qui peut être utilisé pour détecter des organophosphates et du carbamate sur des surfaces comprenant des aliments, des vêtements (comprenant des détecteurs de pesticides portables) et des machines.
Patent WO-2020231764-A1 (WO)
Inventor: WANG YI-SHENG
IPC: G06K9/46
Filed: 2020-05-08
Abstract: Disclosed herein are methods and apparatus for reducing errors in spectroscopic measurements. The present method minimizes errors by aligning peak positions and recalculating intensities in every single-scan spectrum with reference to spectral features observed in the spectrum integrating all uncorrected single-scan spectra. Additionally, the corrected single-scan spectra are integrated to improve the resolving power, signal intensity and peak shape.
Patent WO-2020232262-A1 (WO)
Title: Méthodes d'essai pour la détection de vcam-1 et de la calprotectine
Inventor: MIMMS LARRY
IPC: G01N33/542
Filed: 2020-05-14
Abstract: L'invention concerne des méthodes d'essai pour détecter la présence ou la quantité de VCAM-1 ou de calprotectine dans un échantillon par transfert d'énergie de fluorescence par résonance (FRET).
Patent WO-2020236707-A1 (WO)
Inventor: MUKHERJEE MITRAJIT
IPC: B01J37/03
Filed: 2020-05-18
Abstract: A catalyst, methods of making, and process of dehydrogenating paraffins utilizing the catalyst. The catalyst includes at least 20 mass% Zn, a catalyst support and a catalyst stabilizer. The catalyst is further characterizable by physical properties such as activity parameter measured under specified conditions. The catalyst may also be disposed on a porous support in an attrition-resistant form and used in a fluidized bed reactor.
Patent WO-2020247672-A1 (WO)
Inventor: ZHANG PING
IPC: B60C1/00
Filed: 2020-06-04
Abstract: L'invention concerne une bande de roulement de pneu et un pneu, plus particulièrement un pneu ayant une bande de roulement ou un autre élément élastomère dans des propriétés de matériau composite améliorées, comprenant, mais sans s'y limiter, le rapport de module, le pourcentage d'allongement à la rupture, et/ou la tangente delta, le pneu, la bande de roulement ou autre élément élastomère comprenant des composites caractérisés par une charge de renforcement bien dispersée, qui peut être indiquée par la macrodispersion.
Patent WO-2020252007-A1 (WO)
Inventor: SMITH RODNEY
IPC: C07C2/28
Filed: 2020-06-10
Abstract: Processes and systems for C 3+  monoolefin conversion. In some examples, the process can include reacting a first mixture that includes C 3+  monoolefins and a first oxygenate to produce a first effluent that includes a first ether and < 1 wt. % of any first di-C 3+ olefin. A first product that includes the first ether and a first byproduct that includes at least a portion of any first di-C 3+  olefin and unreacted C 3+  monoolefins can be separated from the first effluent. A second olefin mixture, at least a portion of the first byproduct, and a second oxygenate can be combined to produce a second mixture. The second mixture can be reacted to produce a second effluent that includes a second ether and a second di-C 3+  olefin. The reaction of the second mixture can produce a greater amount, on a mole basis, of the second di-C 3+  olefin than the second ether.