baber/WOPTO huggingface dataset:
Patent NZ-527404-A (NZ)
Title: Phenethanolamine derivatives for treatment of respiratory diseases
Inventor: BIGGADIKE KEITH
IPC: A61P/
Filed: 2002-02-11
Abstract: A compound of Formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 3 to 11; with the proviso that m + n is 5 to 19; R is -XSO2NR6R7 wherein X is - (CH2)p- or C2-6 alkenylene; R6 and R7 are independently selected from hydrogen, C1-6alkyl, C3-7cycloalkyl, C(O)NR8R9, phenyl, and phenyl (C1-4alkyl)-, or R6 and R7, together with the nitrogen to which they are bonded, form a 5-, 6-, or 7- membered nitrogen containing ring, and R6 and R7 are each optionally substituted by one or two groups selected from halo, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, hydroxyl-substituted C1-6alkoxy, -CO2R8, -SO2NR8R9, - NR8C(O)R9, or a 5-, 6- or 7-membered heterocylic ring; R8 and R9 are independently selected from hydrogen, C1- 6alkyl, C3-6cycloalkyl, phenyl, and phenyl (C1-4alkyl)-; and p is an integer of from 0 to 6; R2 and R3 are independently selected from hydrogen, C1-6alkyl, C1-6alkoxy, halo, phenyl, and C1-6haloalkyl; and R4 and R5 are independently selected from hydrogen and C1-4alkyl with the proviso that the total number of carbon atoms in R4 and R5 is not more than 4.
Patent NZ-532608-A (NZ)
Title: Method and apparatus for ozone sterilization
Inventor: ROBITAILLE SIMON
IPC: A61L2/24
Filed: 2002-11-08
Abstract: The sterilization method disclosed includes the steps of providing a sterilization chamber (10); - placing the article into the sterilization chamber; - equalizing the temperature of the article and the sterilization atmosphere; sealing the sterilization chamber; -applying a vacuum (40) of a preselected vacuum pressure to the sterilization chamber; - supplying water vapour (30) to the sterilization chamber under vacuum; - supplying ozone-containing gas (22) to the sterilization chamber; - maintaining the sterilization chamber sealed for a preselected treatment period; and - releasing the vacuum in the sterilization chamber; whereby a vacuum pressure is used which lowers the boiling temperature of water in the sterilization chamber below the temperature in the sterilization chamber. One or more ventilating cycles can be added to the preferred method for removing the remaining ozone and humidity from the sterilization chamber. Single cycle sterilization with ozone is more efficient and provides for a shorter sterilization cycle than with ETO and requires few changes in user habits. Moreover, the ozone-based process in accordance with the invention is compatible for use with current packaging, such as sterile pouches and rigid containers. The sterilization process is simple and substantially avoids human errors caused by false interpretation and handling. The ozone sterilization method of the invention requires substantially no aeration or cooling down of sterilized instruments so that they can be used immediately following the sterilization cycle. This allows hospitals to reduce the cost of maintaining expensive medical device inventories.
Patent NZ-533285-A (NZ)
Title: A structural truss and method for forming a structural truss
IPC: E04C3/292
Filed: 2004-06-01
Abstract: A structural truss comprising a top chord having a first end and a bottom chord having a first end. An end configuration has a web comprising a one piece web member which extends between and interconnects the top chord and bottom chord, the web extending between an intermediate position and the first ends of the top chord and bottom chord; and a connector system for connecting the web to both of the chords inwardly of the first ends of the chords so the entire load applied to the end configuration of the truss when the truss is in use is transferred from the chords to the web inwardly of the first ends of the chords; and wherein the truss is trimmable to a predetermined length by cutting the truss through the chords and the web at a location between the first ends of the chords and the intermediate position without affecting the structural integrity of the end configuration.
Patent NZ-533920-A (NZ)
Title: Defective entities and uses therefor
Inventor: CORNFORD-NAIRN RENEE
IPC: A61K38/00
Filed: 2002-12-30
Abstract: A genetically modified Bordetella strain having partial or complete loss of function in the endogenous aroQ gene product, 3-dehydroquinase, and nucleic acids and polypeptides which disrupt the aroQ gene in a Bordetella cell. Also disclosed are the use of the attenuated Bordetella strains for initiating an immune response and the treatment of whooping cough.
Patent NZ-535192-A (NZ)
Title: Pharmaceutical compositions comprising at lease one ACE inhibitor in a liquid or gel formulation for transmucosal uptake
Inventor: QUAY STEVEN C
IPC: A61K31/473
Filed: 2003-05-19
Abstract: Methods and compositions are disclosed that provide acetylcholinesterase inhibitors for the prevention and treatment of diseases and disorders of the central nervous system, including dementia such as Alzheimer's disease, to the central nervous system via intranasal delivery. The methods and compositions of the present invention provide therapeutic concentrations of the acetylcholinesterase inhibitor in the cerebrospinal fluid of a mammal without the attendant disadvantages, risks and side effects of oral or injection delivery. The graph shows a plot of Donepezil cerebral spinal fluid/plasma ratio in a rat, following single-dose nasal administration at time zero, followed by dual measurements of CSF and plasma at 5, 10, 15, 30 and 60 minutes.
Patent NZ-535270-A (NZ)
Title: Composition having gelling properties for the sustained delivery of bioactive substances
Inventor: LEROUX JEAN CHRISTOPHE
IPC: A61K47/14
Filed: 2003-03-12
Abstract: Disclosed herein is a heat-sensitive composition in liquid form, containing - a hydrophobic organic liquid, - an organogelling substance, selected from amino acid derivatives or fatty acid ester derivatives of amino acids, - a bioactive substance, and - optionally, a hydrophilic organic solvent capable of creating weak bonds with the organogelling substance, which changes to the organogel form when it comes into contact with a physiological fluid, during its administration to an animal body, in particular man, either by cooling the site of application of the said composition or by diffusion of the said hydrophilic organic solvent into the aqueous medium. These heat-sensitive compositions are useful in the field of the sustained delivery of bioactive substances from the medicaments.
Patent NZ-538428-A (NZ)
Title: Use of alkylphosphocholines in combination with antitumor medicaments
Inventor: ENGEL JURGEN
IPC: A61K31/661
Filed: 2003-07-29
Abstract: At least one alkylphosphocholine of the general formula I and II is described to be used in the manufacture of a drug product for the treatment of benign and malignant oncoses before and/or during treatment with an antitumor medicament. The antitumor medicament is selected from the group comprising carboplatin, oxaliplatin, bleomycin, doxorubicin (Adriamycin), methotrexate, paclitaxel, docetaxel, vincristine, vinblastine, etoposide, teniposide, ifosfamide, 5-fluorouracil, fludarabine and cytarabine. The variables of formula I and II are independently of one another as follows. n, m, p, z are an integer between 0 and 4; X are O,S, NH; R is H, a straight-chain or branched (C1-C20)-alkyl radical which may be saturated or unsaturated with one to three double and/or triple bonds and which may be unsubstituted or optionally substituted on the same or on different C atoms by one, two or more halogen, nitro, cyano, hydroxyl, (C1-C6)-alkoxy, amino, mono-(C1-C4)-alkylamino or di-(C1-C4)-alkylamino radicals; R1, R2 and R3 are H, a straight-chain or branched (C1-C6)-alkyl radical, a (C3-C7)-cycloalkyl radical and which may be unsubstituted or optionally substituted on the same or on different C atoms by one, two or more halogen, nitro, cyano, hydroxyl, (C1-C6)-alkoxy, amino, mono-(C1-C4)-alkylamino or di-(C1-C4)-alkylamino radicals.
Patent NZ-539472-A (NZ)
Title: Protein modification
Inventor: VAN BERKEL PATRICK
IPC: C12P19/44
Filed: 2003-10-17
Abstract: Disclosed are C1 inhibitors which are characterised in that their plasma circulatory half-life has been changed by modification of an O-linked carbohydrate, with the proviso that the modification is not desialylation of the O-linked carbohydrate.
Patent NZ-541047-A (NZ)
Title: Deuterated catecholamine derivatives and medicaments comprising said compounds
Inventor: ALKEN RUDOLF-GIESBERT
IPC: C07B59/00
Filed: 2003-12-18
Abstract: The disclosure concerns deuterated catecholamine derivatives, such as L-dopa (levodopa), as well as their carboxylic acid esters, utilised, amongst other things, in the treatment of Parkinson's disease and restless leg syndrome, as well as pharmaceuticals containing these compounds. More specifically the disclosure concerns deuterated catecholamine derivatives of the general formula (I) wherein: R1 is H or D, R2 indicates H or D, R3 is H, D, C1-C6 alkyl or C5 to C6-cycloalkyl, deuterated C1 to C6-alkyl or C5 to C6-cycloalkyl, R4 indicates H or D and R5 is H or D, with the exception of L-2-amino-3,3-dideutero-3-(3,4-dihydroxyphenyl) propionic acid.
Patent NZ-542624-A (NZ)
Title: Hinge, typically for shower glass door, being adjustable
Inventor: REICHEL GUNTER
IPC: E05F1/06
Filed: 2004-03-17
Abstract: Disclosed is a fitting for shower partition parts made of a flat material such as, glass, plastic or similar. The door elements thereof (E, F) thereof have bores (B) which are arranged in the vicinity of a high edge (H) in order to receive hinge plate parts (18, 38). The fitting has three main components. A strip-shaped fixed part (10) has a stop clamping plate (12), wherein a bearing for a clamping disk can be fixed to a door element (E) and can be adjusted in a two-dimensional manner in the lower part of the body thereof. A displaceable strip-shaped housing part (20) can be fixed to the lower part of the bushing (22). The strip-shaped wing part (30) comprises a recess which is arranged in the plate body (32) with the upper part of the bushing (42) in order to receive projections (35) of a second clamping disk (38) which can be fixed to a bore of a door wing (F). The strip-shaped wing part (30) is mounted in a sliding manner on the strip-shaped fixed part (10) in a height displaceable manner, wherein the lower part of the bushing (22) and the upper part of the bushing (42) engage with each other in a flush manner. The stop clamping plate (12) and the housing part (20) are detachably guided in a dovetail manner. A strip, a chamfer or similar, is arranged on a high edge (H) of the door element (E) when in mounted. Said strip, chamfer or similar can be fixed and braced in a selected position by means of an aligning eccentric in a recess of the lower body. The strip-shaped wing part (30) can be engaged in preferred pivoting positions in relation to the fixed part (10).
Patent NZ-545472-A (NZ)
Title: 7-(4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl)quinolonecarboxylic acid derivative
Inventor: ASAHINA YOSHIKAZU
IPC: A61K31/4709
Filed: 2004-09-08
Abstract: Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. The compounds have antibacterial activity against gram-positive bacteria, in particular, resistant bacteria such as MRSA, PRSP, and VRE.
Patent NZ-545720-A (NZ)
Title: Anti-glypican 3 antibody
Inventor: NAKANO KIYOTAKA
IPC: C12P21/08
Filed: 2005-07-08
Abstract: Provides are specified anti-glypican 3 antibodies, corresponding polynucleotides, which are useful as anticancer agents. Also provided are methods of producing the antibodies.
Patent NZ-547278-A (NZ)
Title: Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors for chemosensitization or radiosensitization
Inventor: MABIRE DOMINIQUE JEAN-PIERRE
IPC: C07D491/10
Filed: 2004-11-18
Abstract: Disclosed is a compound of formula (I), or an N-oxide form, addition salt, or stereoisomer thereof, wherein n is 0 or 1, s is 0 or 1, X is ûN= or ûCR4=, Y is ûN< or ûCH<, Q is ûNHû, ûOû, ûC(=O) û, ûCH2-CH2û, or ûCHR5û, R1 is C1-6alkyl or thienyl, R2 is hydrogen, and wherein the rest of the substituents are defined in the specification. Also disclosed is the use of the compounds as chemosensitization or radiosensitization agents for the treatement of cancer. Also disclosed is a process for making the compound.
Patent NZ-550342-A (NZ)
Title: Improved apparatus for electrically mediated delivery of therapeutic agents
Inventor: MASTERSON STEVEN P
IPC: A61M5/20
Filed: 2005-03-08
Abstract: An injector apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient includes a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and a structure incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimetre) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. An electrical field is operatively connected to the electrodes in their deployed state to facilitate the intracellular delivery of a therapeutic agent.
Patent NZ-550573-A (NZ)
Title: Body pulsating method and apparatus
Inventor: HANSEN CRAIG N
IPC: A61M15/00
Filed: 2005-04-20
Abstract: A vest for a human body with an air core coupled to a pulsator operable to subject the vest to pulses of air, which applies and releases high frequency pressure forces to the body. The pulsator has two diaphragms connected to a brushless electric dc motor with rotary to reciprocating linear motion transmitting mechanisms comprising scotch yokes having anti-lash assemblies operable to generate air pulses in an air pulsing chamber. A check valve connects the manifold chamber with the pulsing chamber to allow pressurized air to flow from the manifold chamber into the pulsing chamber. An airflow control valve in communication with the manifold chamber is used to adjust the pressure of the air in the manifold and pulsing chambers. A programmable motor controller adjusts the duration of operation and speed of the motor to vary the operational time and frequency of the air pulses.
Patent NZ-554743-A (NZ)
Title: Dairy product and process
Inventor: YE AIQIAN
IPC: A23L29/275
Filed: 2007-04-24
Abstract: Disclosed is a method for preparing a viscoelastic fluid comprising: (a) mixing oil or fat or a mixture of oil and fat with an aqueous medium to form an oil-in-water emulsion comprising 2% to 12% (w/w) of protein that can form a heat-set gel and 5% to 40% (w/w) oil or fat or a mixture of oil and fat, and homogenising the mixture at a pressure in the range 100 to 2000 bar; (b) heating the homogenised emulsion to 50 deg C to 200 deg C without allowing a gel to form, for a period sufficient to denature the proteins; (c) optionally cooling; (d) allowing the heat-treated emulsion to form a gel by a method selected from adding a salt, and acidification; and (e) subjecting the gel to shearing to form a viscoelastic fluid. Also disclosed is a method for preparing a viscoelastic fluid comprising: (a) mixing oil or fat or a mixture of oil and fat with an aqueous medium to form an oil-in-water emulsion comprising 2% to 12% (w/w) of protein that can form a heat-set gel and 5% to 40% (w/w) oil or fat or a mixture of oil and fat, and homogenising the mixture at a pressure in the range 100 to 2000 bar; (b) heating the homogenised emulsion to 50 deg C to 200 deg C for a period sufficient to denature the proteins and form a gel; (c) optionally cooling; and (d) subjecting the gel to shearing to form a viscoelastic fluid; wherein the heating is carried out either in the presence of a salt or at a pH of less than 5.5. Also disclosed is a method for preparing a viscoelastic fluid comprising: (a) heating aqueous protein to 50 deg C to 200 deg C for a period sufficient to denature the proteins; (b) mixing the heat treated aqueous protein with oil or fat or a mixture of both, wherein the mixture comprises 2% to 12% (w/w) of whey protein and 5% to 40% (w/w) oil or fat, and homogenising the mixture at a pressure in the range 100 to 2000 bar to form a gelled oil-in-water emulsion; (c) optionally cooling; (d) allowing the emulsion to form a gel by a method selected from adding a salt, and acidification; and (e) shearing the gel to form a viscoelastic fluid.
Patent NZ-560861-A (NZ)
Title: System and method for foreign code detection
Inventor: HATLELID KRISTJAN
IPC: G06F9/44
Filed: 2006-04-06
Abstract: A method of detecting an attempt to execute foreign code is disclosed. The method includes: identifying a page of memory that contains code, based on a standard as to the likelihood that the code contained in the page will be executed, wherein the standard is a page fault history that identifies the page as being paged-in to physical memory and any calling code invoking the page to be paged-in; verifying that the code satisfies an integrity test; and taking at least one action to prevent the code from executing, if the code does not satisfy the integrity test. Identifying the page includes reviewing the page fault history, which is a record of each page paged into the physical memory and also the calling code which requested the paged-in page, to identify the paged-in page and the calling code thereof.
Patent NZ-566921-A (NZ)
Title: Contact sensors for monitoring body activity with support element between contact and cover membranes with cover membrane of greater elasticity
Inventor: DIAS TILAK KITHSIRI
IPC: A41D13/12
Filed: 2006-09-29
Abstract: A non-invasive sensor has a contact membrane (16) and a cover membrane (12), the cover membrane being adapted for extension of a body surface to project the contact membrane against a body surface beneath it. The contact membrane will normally be attached to the cover membrane around its periphery such that at least one of the membranes forms a convex outer surface, and a spacing material (20) can be interposed between the membranes to achieve this object. The cover membrane extends over a support element (10), with the contact membrane overlaying and spaced from the other face of the support element by spacing material. The cover membrane has greater elasticity than the contact membrane.
Patent NZ-569546-A (NZ)
Title: Human anti-IL-23 antibodies, compositions, methods and uses
Inventor: ORLOVSKY YEVGENIYA I
IPC: A61K39/395
Filed: 2006-12-28
Abstract: Disclosed is an isolated IL-23p19 antibody. Also disclosed is the use of the antibody in the manufacture of a medicament for diagnosing or treating an IL-23 related condition selected from psoriasis, psoriatic arthritis, Crohn's disease, multiple sclerosis and optic neuritis.
Patent NZ-571145-A (NZ)
Title: Automated ash removal system for a pellet stove using a motor to move part of the floor of the firebox
Inventor: MCCORMICK COLIN J
IPC: F24B1/18
Filed: 2007-03-08
Abstract: A pellet stove that includes a firepot assembly is disclosed. The firepot has a bottom plate slideable along rails to move between a closed position during combustion in the firepot and an open position during ash removal. Also disclosed is a firebox (201) or combustion enclosure includes a plurality of airfoils (202) formed on the inner and outer surfaces of the enclosure to facilitate heat exchange between exhaust gases flowing across the inner surface of the enclosure and air blown across the outer surface of the enclosure. The airfoils and enclosure may be of integral unibody construction. A user adjustable a wall control unit can set parameters controlling the stove. A stove control unit receives the parameters and automatically controls fuel feed rate, ignition, convection blower, combustion blower, and/or firepot cleaning based on the one or more parameters.
Patent NZ-572775-A (NZ)
Title: Human binding molecules having killing activity against enterococci and staphylococcus aureus and uses thereof
Inventor: THROSBY MARK
IPC: C07K16/12
Filed: 2007-06-05
Abstract: Disclosed is a human monoclonal antibody, wherein said antibody comprises: a heavy chain CDR1 region comprising amino acid sequence SEQ ID NO: 296; a heavy chain CDR2 region comprising amino acid sequence SEQ ID NO: 297; a heavy chain CDR3 region comprising amino acid sequence SEQ ID NO: 298; a light chain CDR1 region comprising amino acid sequence SEQ ID NO: 299; a light chain CDR2 region comprising amino acid sequence SEQ ID NO: 300; a light chain CDR3 region comprising amino acid sequence SEQ ID NO: 301; characterized in that said antibody has opsonic phagocytic killing activity against at least one strain of each of at least two different Enterococcus species and against at least one strain of Staphylococcus aureus.
Patent NZ-576153-A (NZ)
Title: Hydrates of 4-{ 4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy} -pyridine-2-carboxylic acid methylamide
Inventor: GRUNENBERG ALFONS
IPC: C07D213/81
Filed: 2007-09-29
Abstract: Disclosed is the monohydrate of the compound 4-[4-({ [4-chloro-3-(trifluoromethyl)phenyl]carbamoyl} amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide (also known as 4-{ 4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy} -pyridine-2-carboxylic acid methylamide). Further disclosed is a pharmaceutical composition which comprising mainly the compound as defined above, no significant fractions of another form of the compound and one or more inert, nontoxic, pharmaceutically suitable excipients for the treatment of solid tumors, lymphomas, sarcomas, leukemias, cancers of the breast, respiratory tract, brain, reproductive organs, digestive tract, urinary tract, eye, liver, skin, head and neck, thyroid and/or parathyroid.
Patent NZ-579228-A (NZ)
Title: Portable spool support
Inventor: GRICE THOMAS CHARLES JOSEPH
IPC: F16M11/32
Filed: 2009-08-21
Abstract: A portable spool support including a mounting member for location through a spool and a pair of support members attached to the mounting member. Each support member is formed from at least two legs, the legs being pivotal with respect to each other. The mounting member is removably attached to the pair of support members and an aperture extends through at least two of the legs of each support member to support the mounting member.
Patent NZ-579414-A (NZ)
Title: Cigarette with a flow restricor and glycerine as an aerosol former
Inventor: OLEGARIO RAQUEL M
IPC: A24D3/04
Filed: 2008-03-10
Abstract: Disclosed is a smoking article having a tobacco rod with a smokeable material including glycerine in an amount of 5 wt% to 15 wt% as an aerosol former; and a filter comprising: a first filter segment; a flow restricting filter segment at a location adjacent and in a downstream relation to the first filter segment; a cavity in communication with and in a downstream relation to the flow restricting filter segment; and a ventilation zone at a location along and communicating with the cavity. The ventilation zone is in a downstream relation to the flow restricting filter segment.
Patent NZ-580746-A (NZ)
Title: Cross-species-specific bispecific binders
Inventor: KLINGER MATTHIAS
IPC: C07K16/30
Filed: 2008-04-03
Abstract: A polypeptide that comprises a first antigen binding domain from an antibody that recognises an epitope from human and Callithrix jacchus, Saguinus oedipus or Saimiri sciureus CD3 epsilon chain. The epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NO: 2, 4, 6 or 8 and comprises at least the amino acid sequence Gln-Asp-Gly-Asn-Glu. The polypeptide further comprises a second binding domain capable of binding to EGFR, Her2/neu or IgE from a human or non-chimpanzee primate.