baber/WOPTO huggingface dataset:
Patent EP-0893999-B8 (EP)
Inventor: MIYAMOTO MISAO
IPC: A61K9/16
Filed: 1997-03-17
Granted: 2003-01-02
Abstract: An amorphous solid dispersion of efonidipine hydrochloride having a high intestinal absorbability can be formed by subjecting a mixture containing efonidipine hydrochloride of the formula (I), hydroxypropylmethylcellulose acetate succinate and optionally a thermostabilizer to a step A of heat treatment at from 85 to 140° C. or mechanochemical treatment at from 0 to 140° C., and then to a step B of dipping treatment into a water-containing solution, impregnation treatment with a water-containing solution or contacting treatment with a water vapor-containing gas; or treating the above-mentioned mixture with a hot steam at from 100 to 140° C. and a high pressure. Further, in the above-mentioned step A, the mixture is subjected to high frequency heating, making it possible to give a solid dispersion of efonidipine hydrochloride having a high intestinal absorbability without using the step B. This process is quite advantageous in the production in that the use of an organic solvent is not required. Formula (I):
Patent BR-PI0911577-B8 (BR)
Title: derivados espiro-indol, seus usos no tratamento de doenças parasíticas, e composição farmacêutica
Inventor: BIN ZOU
IPC: A61K31/424
Filed: 2009-04-01
Abstract: derivados espiro-indol para o tratamento de doenças parasíticas. a presente invenção refere-se a compostos orgânicos que têm propriedades farmacêuticas interessantes. em particular, os compostos são úteis no tratamento e/ou prevenção de infecções tais como aquelas causadas por plasmodium falciparum, plasmodium vivax, plasmodium malariae, plasmodium ovale, trypanosoma cruzzi e parasitas do gênero leishmania tal como, por exemplo, leishmania donovani. a invenção também se refere a composições farmacêuticas contendo os compostos, bem como processos para sua preparação.
Patent BR-PI0924110-B8 (BR)
Title: Processo e planta para a produção de óxido de metal partindo de sais de metal
Inventor: MICHAEL MISSALLA
IPC: C01F7/44
Filed: 2009-12-18
Abstract: PROCESSO E PLANTA PARA A PRODUÇÃO DE ÓXIDO DE METAL PARTINDO DE SAIS DE METAL. A presente invenção refere-se a uma produto de óxido de metal a partir de sais de metal, em particular de hidróxido de alumínio, em que o sal de metal é preaquecido em um primeiro estagio de preaquecimento, pré-calcinado em um segundo estagio de preaquecimento e calcinado a óxido de metal em um reator com leito fluidizado e em que o produto obtido então resfriado em pelo menos um trocador de calor para suspensão e subsequentemente em um resfriador indireto de multiestágio. Para reduzir a demanda de energia de uma planta para calcinação, o ar de fluidização é fornecido ao reator com uma temperatura de até 150°C e antes de entrar no primeiro estagio de preaquecimento o sal de metal é pelo menos em parte fornecido a um secador para hidrato, em que ele é aquecido indiretamente com o meio de transferência de calor proveniente do primeiro estagio do resfriador indireto e seco.
Patent AU-2002352938-B8 (AU)
Title: Materials and methods for preventing and treating microbe-mediated epithelial disorders
Inventor: ALVERDY JOHN C M D
IPC: A61K47/34
Filed: 2002-11-26
Granted: 2009-10-08
Abstract: The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such as dextran and/or essential pathogen nutrients such as L-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.
Patent BR-112015013657-B8 (BR)
Title: Dispositivo elétrico e método de fabricar dispositivo elétrico
Inventor: ROGER HEDLUND
IPC: H01B17/28
Filed: 2013-12-05
Abstract: DISPOSITIVO ELÉTRICO DISPOSTO PARA PROVER ISOLAMENTO ELÉTRICO DE CONDUTOR, PEÇA DIELÉTRICA E MÉTODO DE FABRICAR DISPOSITIVO ELÉTRICO. O método refere-se a um dispositivo elétrico que compreende pelo menos dois eletrodos (120) que são separados por uma peça dielétrica (125). Pelo menos um dos ditos eletrodos (120) é disposto para estar em um potencial flutuante. A peça dielétrica (125) compreende pelo menos uma volta (200) de pelo menos um filme não impregnável eletricamente isolante (205) entre dois eletrodos (120) vizinhos. Os eletrodos (120) são ligados a voltas (200) adjacentes de filme isolante não impregnável (205), e voltas (200) adjacentes de filme isolante não impregnável (205), caso haja alguma, são ligadas entre si, de modo que as voltas (200) de filme isolante não impregnável (205) e os eletrodos (120) formem um corpo sólido. A invenção adicionalmente refere-se a um método de fabricar um dispositivo elétrico, onde a ligação de pelo menos uma volta (200) é executada com a formação da dita volta (200), de modo que a ligação da dita volta à volta (200)/eletrodo (120) localizados abaixo comece antes de a dita volta (200) ter sido completamente coberta pela próxima volta (200).
Patent EP-1404704-B9 (EP)
Inventor: FARMER LUC
IPC: C07K7/06
Filed: 2002-07-11
Granted: 2008-02-20
Abstract: The present invention relates to peptidomimetic compounds which inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The compounds of this invention have a bridged bicyclic moiety at the P2 position. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.
Patent EP-0744409-B9 (EP)
Inventor: YAMASAKI MOTOO
IPC: A61K38/19
Filed: 1995-02-23
Granted: 2009-08-19
Abstract: The invention relates to a polypeptide wherein at least one of the amino, carboxyl, mercapto or guanidino group in a polypeptide molecule having human granulocyte colony stimulating factor activity is chemically modified by a chemical modifying agent, and a platelet production promoter comprising said polypeptide, a method for treating a patient with decreased platelet counts comprising administering an effective amount of said polypeptide to the patient, the use of said polypeptide for the production of pharmaceutical compositions which are useful for the treatment of the patient with decreased platelet counts, and the compositions for treating the patient with decreased platelet counts, which comprises an effective dose of said polypeptide in a pharmaceutically acceptable dosage form with a pharmaceutical acceptable carrier.
Patent EA-036231-B9 (EA)
Title: Nano-bubble generator and method of generating nano-bubbles
Inventor: BOTHA QUARTUS PAULUS
IPC: C02F9/12
Filed: 2017-09-06
Abstract: A nano-bubble generator (10) includes: (i) a housing (12) defining an inlet (24) for receiving a liquid with entrained macro-bubbles; a first chamber (20) operatively downstream of the inlet; a second chamber (22) operatively downstream of the first chamber (20); and an outlet (26) operatively downstream of the second chamber (22); (ii) at least one blade (30) disposed within the first chamber (20) for, in use, cutting macro-bubbles entrained in the liquid to convert such macro-bubbles into micro-bubbles; (iii) at least one first magnet (32) within the second chamber (22); and (iv) at least one second magnet (34) associated with the second chamber (22), wherein (a) the at least one first magnet (32) and the at least one second magnet (34) are arranged such that the polarity of the at least one first magnet (32) is opposed to the at least one second magnet (34); and (b) the at least one first magnet (32) is movable relative to the at least one second magnet (34).
Patent AU-2007300299-B9 (AU)
Title: Systems and methods of remotely controlling a materials handling vehicle
Inventor: JENSEN ERIC
IPC: G08C17/02
Filed: 2007-09-14
Granted: 2012-02-09
Abstract: A supplemental control system for a materials handling vehicle comprises a wearable control device, and a corresponding receiver on the materials handling vehicle. The wearable control device is donned by an operator interacting with the materials handling vehicle, and comprises a wireless transmitter and a travel control communicably coupled to the wireless transmitter. Actuation of the travel control causes the wireless transmitter to transmit a first type signal designating a request to advance the vehicle in a first direction. The receiver is supported by the vehicle for receiving transmissions from the wireless transmitter. A traction control of the vehicle is responsive to a receipt of the first type signal by the receiver to cause the vehicle to advance.
Patent AU-2018255926-B9 (AU)
Title: Improved T cell compositions and methods
Inventor: CHAPARRO RIGGERS JAVIER FERNANDO
IPC: A61P37/06
Filed: 2018-04-18
Granted: 2023-10-19
Abstract: The present invention provides compositions and methods that downregulate major histocompatibility class I molecule cell surface expression, and uses of such compositions and methods for improving the functional activities of isolated T cells (e.g., gene-modified antigen-specific T cells, such as chimeric antigen receptor T (CAR-T) cells). In particular, the present invention provides methods and compositions for bolstering the therapeutic efficacy of CAR-T cells.
Patent DE-3139689-C1 (DE)
Title: Device for introducing solid, liquid or gaseous treatment substances for upgrading polluted water
Inventor: LEISTNER KURT
IPC: B01F7/02
Filed: 1981-10-06
Granted: 1983-07-28
Abstract: Devices are known for introducing atmospheric oxygen into waste water (effluent) by means of a driven propeller freely arranged in the water, which devices divide this supplied air into bubbles and produce a water/air bubble stream. The oxygen contained in the air diffuses at the air/water interfacial area into the water. The object is to produce a multiplicity of bubbles and a multiplicity of new interfacial areas on these with the use of less drive power. According to the invention this is achieved in that the air, in front of the propeller, is already blended in a finely distributed manner with the water stream flowing to the propeller. Instead of water, the propeller processes a water/air bubble mixture, which is more fluid and lighter than water, with a markedly lower power requirement for this purpose, with additional incorporation of oxygen and thus an improved jet formation. This can be carried out for example by means of a hollow cone arranged in front of the propeller, which hollow cone has a multiplicity of orifices, stationary or rotating. In this context see Figure 3, with air supplied through a stationary hollow cone and schematic representation of the air incorporation. <IMAGE>
Patent DE-3502844-C1 (DE)
Title: Piston ring seal for a piston-cylinder arrangement
Inventor: KRIECHBAUM KARL DR-ING
IPC: F16J9/26
Filed: 1985-01-29
Granted: 1986-03-13
Abstract: Piston ring seal for a piston-cylinder arrangement, preferably that in compressors, using at least one piston ring composed of PTFE, the latter containing in particular additions comprising carbon, graphite or the like, which is guided in a groove arranged in the piston or cylinder. For a piston ring seal of this kind, the leak-tightness required for each particular application is guaranteed using technically simple means by virtue of the fact that an elastomer ring which is supported against the base of the groove is inserted into the groove, pressing the piston ring radially outwards or inwards, as appropriate, over its entire circumferential radius away from the base of the groove and against the wall of the cylinder or piston. The elastomer ring can be designed as a flat ring with a rectangular cross-section. It can also be provided with concentric beads, which are arranged on at least one of its radial walls. <IMAGE>
Patent DE-3512333-C1 (DE)
Title: Portable reserve car fuel tank filler - comprise flexible transfer tube with section to open tank lead-free petrol valve
Inventor: ZEIGMEISTER HANS-JOACHIM
IPC: B65D25/48
Filed: 1985-04-03
Granted: 1986-10-02
Abstract: A portable reserve fuel tank is discharged into the fuel tank on the car by a flexible transfer tube (1). The leading end (3) on the transfer tube is provided with a cross section profile that opens a valve in the car tank when lead free petrol is transferred. Axial press forming of the tube section (2,4) produces an internal secondary duct (5), which provides ventilation for the reserve tank when petrol is discharged from it. ADVANTAGE - Coupling tube for filling car fuel tank from portable reserve tank can be used for standard and lead-free petrol.
Patent DE-3515129-C1 (DE)
Title: Test device for a plurality of identical workpieces with reference to their dimensional stability at specific reference points
Inventor: KOCHANNEK HORST
IPC: G01B5/00
Filed: 1985-04-26
Granted: 1986-04-10
Abstract: The invention relates to a test device for a plurality of identical workpieces with reference to their dimensional stability at specific reference points. The test device has a guide sleeve with a large, disc-shaped collar which can be moved on all sides free from play in a horizontal plane. Guided free from play in the guide sleeve is a sleeve which can be mounted with its prod on the reference points of the workpiece. Clamped to the sleeve in order to determine the position of the reference point is a first dial gauge, which is supported on the end face of a measurement ring moving along with the guide sleeve. A further dial gauge is pivotably mounted in a horizontal plane and touches the cylindrical reference surface, located on the outer circumference, of the measurement ring. By pivoting this further dial gauge around, the extent of the excentricity of the reference point can be determined with respect to its normal position and, as the case may be, the direction of the excentricity can also be determined. The advantage of this test device consists in its simple design; at the same time, it operates very reliably and accurately.
Patent DE-3807481-C1 (DE)
IPC: G10G7/00
Filed: 1988-03-08
Granted: 1989-03-16
Abstract: Hitherto, the main part of a case and the cover of a case have usually been joined together via hinges arranged along the long side, so that such a case must be opened in the horizontal state. Particularly with cases for relatively large bowed or plucked stringed instruments, this requires a correspondingly large space. In the case according to the invention, the swivelling axis of the cover is located on the narrow side 6 on the side of the tip, so that the case can be folded open in the upright state. The cover 2 covers the bottom side of the instrument. In the open state, the cover has a slight curvature 16 pointing away from the main part of the case. In the rim region of the allround rib 5 of the cover, an allround inner gasket 17 and outer gasket 18 each projecting over the rim edge are fitted, the rim region of the rib of the main part 1 of the case fitting smoothly into the space 19 between the gaskets when the case is closed. <IMAGE>
Patent DE-3828293-C1 (DE)
Title: Harvesting attachment
IPC: A01D41/14
Filed: 1988-08-19
Granted: 1990-01-25
Abstract: To improve the pivotability of individual elements on harvesting attachments and space utilisation, it is proposed to mount the reaping and/or conveying elements respectively on two supporting arms, the pivot axes of which are arranged in direct proximity, on the edge or above or below the drums, to the reaping and/or conveying elements. To reduce the overhang in the direction of travel and the overall length, it is proposed, furthermore, to pivot the drums which are the outer in the working position over or onto the inner drums for the transport position. The proposals achieve a space-saving mounting which is firm under operating conditions.
Patent DE-3841438-C1 (DE)
Title: Method and device for fastening electrical connecting bolts which are inserted into holes in a printed circuit board
IPC: H01R43/20
Filed: 1988-12-09
Granted: 1990-04-12
Abstract: In order to solder electrical connecting bolts into printed circuit boards, the bolts are gripped by a robot, are then inductively heated in an induction furnace and are subsequently inserted into the printed circuit board by the robot, the soldering process being initiated by the intrinsic heat of the connecting bolt melting the soldering paste. In a particularly advantageous embodiment, two induction furnaces are provided in which the bolts are heated alternately in sequence, so that the soldering process takes place without interruption and is automated.
Patent DE-3936974-C1 (DE)
Title: Treatment of paint coagulate - comprises mixing fibres with coagulate, forming layer and heat treating
IPC: B29B17/00
Filed: 1989-11-07
Granted: 1990-09-27
Abstract: A process for treating dewatered and dried paint coagulate following the cleaning out of spray colour, includes mixing fibres with the coagulate, forming a layer, and heat treatment at at least 130 deg.C under pressure in a mould. The water used to wash out the cabih is supplied with al oxide which acts as a coagulating agent. The water is removed and the paint coagulate is then carefully heated to form a pourable powder. After further drying to a residual wetness of 2-10% the fibres are added. The coagulate is pref. mixed with bitumen. ADVANTAGE - The process results in reduced press times and the transport wt. and vol. of the coagulate are reduced.
Patent DE-4017131-C1 (DE)
IPC: H01R12/04
Filed: 1990-05-28
Granted: 1991-11-07
Abstract: A holder for an essentially cylindrical miniature incandescent lamp for placement onto a printed-circuit board such that it makes contact, having contact elements which open in the base surface, are intended for resting on mating contact surfaces of the printed-circuit board and can be connected to the lamp wires such that they make contact electrically, said holder being provided with a recess which reaches at least into the vicinity of the lower, essentially flat base surface and is intended to hold the miniature incandescent lamp in a horizontal position. 
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Patent DE-4038650-C1 (DE)
Title: Pressure pulse concretion remover - has pulsed pressure source and pulse generator in common housing
IPC: G10K9/12
Filed: 1990-12-04
Granted: 1992-04-16
Abstract: The pulsed pressure generator includes a pulsed pressure source (2), a h.v. pulse generator (8) and a housing (1) in which the pulsed pressure source (2) and at least the output stage of the h.v. pulse generator are accommodated for forming a structural unit. The two terminals (16) and (17) of the h.v. capacitor (15), forming part of the generator`s (8) output stage are connected to a charging current source (18) which is used to charge the h.v. capacitor (15) up to a high voltage level. Terminal (16) of the capacitor (15) is connected via a h.v. line (6) to a coil (4), which forms part of a shock (impact) wave source (2). USE - In medicine for breaking up concretions, non-invasively, in the body of a patient etc.
Patent DE-4120689-C1 (DE)
Title: Electron-beam hardening cutting area of flat tool - by overlap mounting blades, while leaving area to be hardened uncovered etc.
IPC: C21D9/18
Filed: 1991-06-22
Granted: 1992-04-23
Abstract: Cutting area of flat tool; e.g. harvester blades, made of hardenable steel is electron beam-hardened by a method in which blades (1) are mounted to overlap, while leaving the area to be hardened uncovered. The support (3) is moved relative to the energy beam (6), which is moved along scanning lines with a high-frequency periodic motion. The width of the energy transmission area is slightly larger than blade width and isothermal surface energy transmission is achieved. ADVANTAGE - Economic prodn..
Patent DE-4211094-C1 (DE)
Title: Backrest support for vehicle seat - has flexible support plate over U=channel with two sets of shoulders braced on slidable wedge
IPC: A47C7/46
Filed: 1992-04-03
Granted: 1993-06-03
Abstract: The backrest support has a subframe (10) formed as a length of U-channel (12). At each end between the side walls of the channel is a roller (20) on a pivot (18) between which is an endless belt (22). Attached to cross-stays (30) at each end of the channel is a support plate (34), which curves over the U-channel. Projecting downwards from this support plate and upwards from the U-channel are sets of shoulders (24a/b,26a/b,28a/b; 38a/b,40a/b,42a/b), aligned transversely with each other. A wedge (46) can be positioned along the length of the U-channel by the endless belt bracing the support plate against the channel by the shoulders on its slant faces. ADVANTAGE - Simple adjustment of support without affecting position of support plate.
Patent DE-4323185-C1 (DE)
Title: Process for the preparation of polyorganosiloxanes
Inventor: SCHICKMANN HARALD
IPC: C08G77/08
Filed: 1993-07-10
Granted: 1995-01-19
Abstract: The invention relates to a process for the preparation of polyorganosiloxanes by reacting polyorganosiloxanes containing silanol groups with one another or with polyorganosiloxanes containing triorganosiloxy terminal groups, in the presence of a silicon-, phosphorus-. nitrogen- and chlorine-containing catalyst which is a product of the reaction of phosphorus nitrile chloride with tris(triorganosiloxypolyorganosiloxanyl) phosphate.
Patent DE-4333514-C1 (DE)
Title: Roof hatch, in particular for vehicle roofs
Inventor: FIEGEL GUNNAR
IPC: E05F15/63
Filed: 1993-10-01
Granted: 1994-10-13
Abstract: The invention relates to a roof hatch, in particular for vehicle roofs. Such roof hatches have a cover which, in order to uncover a roof opening bounded by a frame, can be hinged out at one of two opposite sides or else at both together. In order to make possible low-friction and low-loss operation using little effort, according to the invention, the connecting rods, which operate the hinging-out devices, are mounted rotatably at one end on the hinging-out devices and at their other end are guided, on the one hand, in connecting-link tracks of a driven cam disc, mounted centrally on the inside of the cover, and, on the other hand, are guided additionally on essentially circular guide tracks fixed on the cover.
Patent DE-4333536-C1 (DE)
Title: Set of repair elements for gas pipes
IPC: F16L5/02
Filed: 1993-10-01
Granted: 1994-11-24
Abstract: The set of repair elements (SBS) comprises a steel pipe (1) having an external thread (6), onto which there may be turned a clamping sleeve (7) with a conical surface (10) on one side. Clamping claws (12) are pushed into the annular space (11) between the steel pipe (1) and the gas pipe (2) remaining in the housing-wall lead-through (9), the gas pipe being cut off in the plane of the inner side (4) of the house wall (5). Said clamping claws have interior tightening surfaces (14) and exterior supporting surfaces (15). Via pressure screws (18), which are screwed into radial flanges (16) of the clamping claws (12) and are supported on a steel disk (20) which presses a sealing ring (22) against the inner side (4) of the house wall (5), the clamping claws (12) can be displaced in the direction of the house interior (3), with the result that the tightening surfaces (14) are drawn onto the conical surface (10) and consequently fix the clamping sleeve (7) in the gas pipe (2). The steel pipe (1) is fixed in position. Thereafter, the annular space (11) is filled with sealant. A plastic cap (27) is then pushed over the pressure screws (18) and the flanges (16). <IMAGE>