baber/WOPTO huggingface dataset:
Patent CA-3174484-A1 (CA)
Inventor: HITKO CAROLYN W
IPC: C12Q1/68
Filed: 2013-12-12
Abstract: The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, or portions, components, or subunits of bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.
Patent CA-3175625-A1 (CA)
Title: Crispr-inhibition for facioscapulohumeral muscular dystrophy
Inventor: JONES PETER L
IPC: C12N15/85
Filed: 2021-04-06
Abstract: The disclosure relates to methods and compositions for inhibiting the expression of the DUX4 gene in skeletal muscle cells. In some aspects, the invention includes a CRISPR interference platform that directs an epigenetic regulator to the DUX4 locus. In some aspects, methods described by the disclosure are useful in modulating DUX4 expression for the treatment of facioscapulohumeral muscular dystrophy (FSHD).
Patent CA-3176239-A1 (CA)
Inventor: LOJEK III JOHN
IPC: B21D26/033
Filed: 2021-04-20
Abstract: A forming assembly configured to form a wick is disclosed. The forming assembly includes an expandable tube and a forming shell assembly. The expandable tube is hydraulically expandable to an expanded configuration. A wick mesh is configured to be wrapped about the expandable tube. The forming shell assembly includes a first forming shell comprising a first recess defined therein and a second forming shell comprising a second recess defined therein. The first recess and the second recess cooperate to define an outer diameter of the wick. The expandable tube and the wick mesh are positionable between the first recess and tire second recess, lire expandable tube and the forming shell assembly are configured to deform the wick mesh and form the wick based on the expandable tube hydraulically expanding towards the expanded configuration.
Patent CA-3176576-A1 (CA)
Inventor: BITEAU JOHN
IPC: G02C7/06
Filed: 2021-04-22
Abstract: L'invention concerne un article optique comprenant un substrat de lentille de base ayant au moins un élément optique ou une pluralité d'éléments optiques tels que des microlentilles, ledit article présentant de bonnes propriétés optiques et de bonnes propriétés mécaniques. Plus précisément, l'invention concerne un article optique comprenant : - un substrat de lentille de base ayant des première et seconde surfaces de lentille opposées; - une couche de protection ayant des première et seconde surfaces de protection opposées, la première surface de protection étant disposée sur la seconde surface de lentille; et - au moins un ou une pluralité d'éléments optiques, chacun : définissant une partie de l'une de la première surface de protection et de la seconde surface de lentille; ayant une hauteur maximale, mesurée dans une direction perpendiculaire à la seconde surface de lentille les portant, qui est inférieure ou égale à 0,1 millimètres (mm) et un diamètre qui est inférieur ou égal à 2,0 mm, la couche de protection étant composée de : un revêtement auto-stratifié ayant au moins deux couches distinctes : - une première couche LSSC1 correspondant à la partie la plus interne de la couche de protection et ayant deux surfaces opposées, une surface correspondant à la première surface de protection - et une seconde couche LSSC2 correspondant à la partie la plus externe de la couche de protection et ayant deux surfaces opposées, une surface correspondant à une seconde surface de protection, le revêtement auto-stratifié résultant de la polymérisation d'une composition auto-stratifiée comprenant au moins deux, de préférence deux compositions de résines incompatibles, la composition de résine 1 et la composition de résine 2, la première couche LSSC1 étant constituée de l'une des au moins deux compositions de résine de résine, la composition de résine 1 après durcissement, la résine durcie 1, ladite résine durcie 1 : - présentant un indice de réfraction nSSC1 qui est inférieur à l'indice de réfraction nm dudit ou desdits éléments optiques de sorte que la différence nm nSSC1 soit supérieure à 0,045, de préférence supérieure à 0,10, ou même supérieure à 0,15; la seconde couche LSSC2 étant constituée de l'autre des au moins deux compositions de résine, la composition de résine 2 après durcissement, ladite résine durcie 2 : - présentant un indice de réfraction nSSC2 qui est similaire ou supérieur à l'indice de réfraction nSSC1. L'invention concerne également le procédé pour former ces articles optiques.
Patent CA-3177170-A1 (CA)
Title: Determination du risque de mortalite de sujets atteints d'infections virales
Inventor: SWEENEY TIMOTHY
IPC: G16B25/00
Filed: 2021-04-29
Abstract: L'invention concerne des systèmes, des méthodes, des compositions, des appareils et des kits pour déterminer le risque de mortalité en 30 jours de sujets atteints d'infections virales, et pour déterminer des stratégies de triage efficaces pour de tels sujets. Les méthodes et les compositions divulguées impliquent des biomarqueurs identifiés à partir de l'application d'un flux de travaux d'apprentissage automatique à des données d'apprentissage de mortalité virale. Les biomarqueurs permettent le calcul d'un score qui peut être utilisé pour déterminer la probabilité de survie de 30 jours chez les sujets.
Patent CA-3177315-A1 (CA)
Inventor: HARRELL ROBERT E
IPC: F25C1/18
Filed: 2021-04-28
Abstract: L'invention concerne un système de fabrication de produits en glace transparente. Le système comprend un module de congélation, un module de démoulage et un poste de façonnage. Le module de congélation comprend un cadre comportant une pluralité de niveaux, un congélateur à plaques disposé à chaque niveau, et au moins un moule pouvant être placé sur chaque congélateur à plaques et adapté à recevoir de l'eau. Un cadre de commande est associé à chaque congélateur à plaques, et peut être déplacé d'une position élevée à une position de remplissage. Dans la position de remplissage, le cadre de commande est disposé au moins partiellement à l'intérieur du moule. Une ou plusieurs pompes de circulation sont associées à chaque cadre de commande, afin de faire circuler l'eau dans le moule pour libérer des bulles d'air à mesure que l'eau gèle. Le module de démoulage retire le moule du module de congélation, et retire du moule la glace formée. Le poste de façonnage transforme la glace formée en un produit en glace transparente.
Patent CA-3179628-A1 (CA)
Inventor: DALBOGE HENRIK
IPC: C09B67/54
Filed: 2021-07-06
Abstract: The present invention provide scalable methods of producing newly identified atrorosin pigments, compositions comprising the pigments, lakes and dyes and uses thereof for colorings foods, such as dairy, meat substitutes or candy.
Patent CA-3180170-A1 (CA)
Title: Filter assembly, filter bag and method of replacing a filter bag
Inventor: PORI SAMU
IPC: B01D46/00
Filed: 2021-01-28
Abstract: The disclosure relates to a filter assembly (16) comprising a frame (6) comprising a frame part (6.1) having a top side (7a), a bottom side (7d), inner edges (7c) defining an aperture (26) and outer edges (7b) forming an outer perimeter of the frame part (6.1), and a bag -like insert (11) comprising filter material and having an open upper portion (14) and at least one closed bottom portion. The insert (11) is fitted into the aperture (26) of the frame (6) with the open upper portion (14) bent over the frame part (6.1) to cover the top side (7a), the outer edges (7b) and at least part of the bottom side (7d) of the frame part (6.1). The upper portion (14) of the insert (11), which is bent over the frame (6), comprises a stretch region (27) made of stretchable material. The insert (11) is fastened to the frame (6) by a pressing force generated by the stretch region (27) against the frame (6).
Patent CA-3181733-A1 (CA)
Title: Enzymes et proteines regulatrices dans le metabolisme de la tryptamine
Inventor: PEIFFER LAURA FLATAUER
IPC: C12N15/09
Filed: 2021-06-04
Abstract: L'invention concerne des acides nucléiques d'origine non naturelle comprenant une séquence codant pour une enzyme ou une protéine régulatrice dans le métabolisme de la tryptamine. L'invention concerne également des micro-organismes recombinés exprimant l'enzyme ou la protéine régulatrice. L'invention concerne en outre des procédés d'expression de l'enzyme ou de la protéine régulatrice.
Patent CA-3184745-A1 (CA)
Inventor: BUCK MICHAEL
IPC: A61M39/06
Filed: 2021-06-24
Abstract: Un système d'aspiration présente une chute accélérée de pression négative au niveau de l'extrémité distale d'un cathéter d'aspiration à partir du moment d'ouverture d'une valve. Le système comprend une pompe d'aspiration en communication avec une première chambre, et un cathéter d'aspiration conçu pour être placé en communication fluidique avec la première chambre au moyen d'un tube d'aspiration allongé. Une seconde chambre est disposée entre le tube d'aspiration et le cathéter, et une valve est disposée entre la seconde chambre et le cathéter d'aspiration. Lors de l'ouverture de la valve avec une pression négative à l'équilibre dans les première et seconde chambres, la résistance à l'écoulement de fluide entre la seconde chambre et l'extrémité distale du cathéter est inférieure à la résistance à l'écoulement de fluide entre la seconde chambre et la première chambre, provoquant une aspiration rapide à l'intérieur de la seconde chambre.
Patent CA-3184802-A1 (CA)
Inventor: LEVY YVES
IPC: C07K14/165
Filed: 2021-05-26
Abstract: The Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic has undeniably emerged as the largest global health threat to humanity in this century. SARS-CoV-2 vaccines will be essential to reduce morbidity and mortality if the virus establishes itself in the population. The inventors have set up candidate vaccines against SARS-CoV-2. In particular, the inventors have identified specific epitopes to be included in vaccine candidates thanks to in silico analysis of the amino-acid sequence of these proteins to map predicted MHC-I and -II epitopes by online software (NetMHC-4.0 and NetMHCII-2.3) and peptide binding prediction software. B cell epitopes were also mapped using online software (BepiPred-2.0 and Discotope), as well as regions rich in epitopes whose sequences are homologous between SARS-CoV-2 and -CoV-1. Finally, the inventors have generated some specific CD40 antibodies comprising one or more SARS-CoV-2 polypeptide(s) of the present invention and that are suitable for vaccine purposes. Therefore, the present invention relates to SARS-CoV-2 polypeptides and uses thereof for vaccine purposes.
Patent CA-3185111-A1 (CA)
Inventor: ARMANI ELISABETTA
IPC: C07D409/04
Filed: 2021-07-15
Abstract: The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 1 (LPA1), particularly the invention relates to compounds that are Ami do cyclohexane acid derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.
Patent CA-3185277-A1 (CA)
Inventor: JAFFEL HAMOUDA
IPC: C04B38/00
Filed: 2021-07-14
Abstract: Lightweight construction panels, such as plasterboard, (e.g. gypsum plasterboard) are commonly used to provide internal partitions in buildings. Sheets of plasterboard are typically carried and positioned by hand. Accordingly, it is desirable to reduce the weight of plasterboard. It is known to include an aqueous foam in the stucco slurry used to produce plasterboards. However, prior known mixers have been found to destroy foam bubbles. The present invention provides a stucco slurry mixing apparatus (100) including an inlet (130) for the introduction of foam into a mixing chamber (110), wherein the inlet (130) includes an inlet aperture (132) in a wall of the mixing chamber (110) and an inlet conduit (134) extending therefrom such that a relative angle between a longitudinal axis (136) of the inlet conduit (134) and a tangent (140) to a mixing path (124) defined by a mixing member (120) is less than 90 degrees.
Patent CA-3186189-A1 (CA)
Inventor: HAFFNER DAVID
IPC: A61M37/00
Filed: 2010-05-18
Abstract: Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
Patent CA-3186772-A1 (CA)
Inventor: TAMPER JUHA
IPC: C08L97/00
Filed: 2021-06-09
Abstract: Est divulgué une composition de lignine dérivée du bois. La composition de lignine dérivée du bois comprend : - de la lignine insoluble dans l'acide en une quantité allant de 80 à 90 % en poids par rapport à la teneur totale en matière sèche de la composition de lignine, le poids moléculaire moyen de la lignine étant compris entre 5 000 et 15 000 Da ; - des glucides en une quantité allant de 1,5 à 15 % en poids par rapport à la teneur totale en matière sèche de la composition de lignine ; - de l'azote en une quantité allant de 0,2 à 1,5 % en poids par rapport à la teneur totale en matière sèche de la composition de lignine ; le rapport en poids de l'oxygène au carbone étant d'au moins 0,5. Est en outre divulgué un procédé de fabrication de la composition de lignine dérivée du bois.
Patent CA-3187748-A1 (CA)
Title: Modular panel assembly
Inventor: LEAVITT DOUGLAS F
IPC: A47K3/28
Filed: 2021-08-25
Abstract: A modular bath or shower panel assembly, comprising a left panel; a center panel; and a right panel, wherein the left panel comprises a side section and a center section having a functional end, the center panel comprises a left functional end and a right functional end, the right panel comprises a side section and a center section having a functional end, and wherein, upon installation of the assembly, the left panel functional end and the right panel functional end are configured to couple to the center panel left functional end and center panel right functional end, respectively.
Patent CA-3189206-A1 (CA)
Inventor: OHARA KENTARO
IPC: A61K45/00
Filed: 2021-07-16
Abstract: The present invention relates to the use of a compound having TRPV4 inhibitory activity, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing these, in the manufacture of a pharmaceutical product for the prevention or treatment of retinal disease that accompanies vascular disorders or cellular disorders. Further, the invention relates to a method of preventing or treating the aforementioned diseases, involving administering said compound or a pharmaceutical composition containing the same to a human or animal. Said compound, pharmaceutically acceptable salt thereof, or pharmaceutical composition containing these may be used in combination with one or more second active drugs. The invention relates to a kit and a pharmaceutical composition, used for the prevention or treatment of the aforementioned diseases and containing a compound having TRPV4 inhibitory activity or a pharmaceutically acceptable salt thereof. The invention further relates to a marker for diagnosing diseases usefully treated by said compound, and a method for screening drugs that prevent or treat the aforementioned diseases.
Patent CA-3189673-A1 (CA)
Title: Systeme de baculovirus modifie pour la production amelioree d'adn a extremites fermees (cedna)
Inventor: MAGHODIA AJAY
IPC: A61K48/00
Filed: 2021-08-23
Abstract: La présente invention concerne un vecteur d'expression de baculovirus recombiné (rBEV) pour la production d'ADN à extrémités fermées (ceDNA) protéines hétérologues dans des cellules d'insectes.
Patent CA-3191619-A1 (CA)
Inventor: PUGSLEY TODD
IPC: B01J23/80
Filed: 2023-03-02
Abstract: Implementations of the present disclosure relate to catalytic compositions useful in hydroprocessing heavy oil feedstocks. The catalytic compositions may be used in methods and systems to facilitate hydroconversion of the heavy oil feedstocks. The catalytic compositions can comprise a combination of a first metal being a transition metal, a second metal and a non-metal, wherein the second metal is a Group 11 transition metal, a Group 12 transition metal, a Group 13 metal or a combination thereof, and wherein the first metal and the second metal are different.
Patent CA-3196700-A1 (CA)
Inventor: LUKIN MIKHAIL D
IPC: G06N10/70
Filed: 2021-11-19
Abstract: Topological qubits are provided in a quantum spin liquid. In various embodiments, a device is provided comprising a two-dimensional array of particles, each particle disposed at a vertex of a ruby lattice having a parameter ? greater than AA; each particle having a first state and an excited state; each particle that belongs to at least three unit cells of the ruby lattice having a blockade radius, when in the excited state, sufficient to blockade each of at least six nearest neighboring particles in the ruby lattice from transitioning from its first state to its excited state, and wherein the array has at least one outer edge configured to be in a first boundary condition.
Patent CA-3197179-A1 (CA)
Inventor: CHEN ZIRONG
IPC: A61P35/00
Filed: 2021-09-28
Abstract: La présente invention concerne des constructions anti-CD93 qui se lient à CD93 (par ex., des anticorps anti-CD93), des molécules d'acide nucléique codant pour une séquence d'acides aminés de l'anti-CD93, des vecteurs comprenant les molécules d'acide nucléique, des cellules hôtes contenant les vecteurs, des procédés de préparation de la construction anti-CD93, des compositions pharmaceutiques contenant la construction anti-CD93 et des procédés d'utilisation de la construction ou des compositions anti-CD93.
Patent CA-3198105-A1 (CA)
Inventor: LIU X SHAWN
IPC: C12N15/79
Filed: 2021-11-11
Abstract: The present disclosure provides for systems and methods for modifying the epigenome of cells.
Patent CA-3198698-A1 (CA)
Inventor: LEADERS JEFFREY L
IPC: G01F1/667
Filed: 2015-08-14
Abstract: A fluid manifold is capable of channeling and monitoring fluid flow within a fluid distribution system. The manifold includes one or more input lumens. Each input lumen associated with a respective inlet port. The manifold also includes a plurality of output lumens such that each output lumen is associated with a respective outlet port and at least one input lumen is coupled to two or more output lumens. The manifold also includes one or more flow sensors capable of measuring fluid flow parameters of fluid flowing through at least one of the one or more input lumens and the plurality of output lumens. In some implementations, a flow sensor can be mounted to each output lumen of the manifold.
Patent CA-3199992-A1 (CA)
Inventor: BEDNARSKI LUKASZ
IPC: G01B21/32
Filed: 2021-11-26
Abstract: Method for identifying a plastic deformation of material of an object in situ using strain sensors operating on the principle of electrical resistive strain gauging, fibre optic measurements using fibre Bragg gratings (FBG), vibrating wire sensors ()VW, distributed fibre optic sensors (DFOS), inductive, capacitive, or piezoresistive sensors, in which in the monitored area (W) subjected to any load condition, there are placed at least four strain sensors (?s) constituting at least two rosettes (I), (II) turned with respect to each other by any angle (?) other than zero and freely shifted with respect to each other by a vector (V) for measuring any plane strain condition, the rotation angle and the displacement of the rosettes (I), (II) are chosen so that no more than two sensors (?s) between the rosettes are parallel to each other or lie on the same straight line, at least two principal strain states (?1, ?2) and principal stresses (?1, ?2) respectively are determined for the monitored area (A), and by monitoring the object, increments of principal strains (??1), (??2) and/or increments of principal stresses (???), (??2) are calculated, in successive moments of time, for each separated rosette, which below the yield point of the monitored area are proportional between the rosettes, on this basis, the plastic deformation of material indices are determined, and by monitoring the area the yield point is detected at the moment of disappearance of the proportionality of the increments, i.e. a sudden change in the value of the determined yield indices normal to the state below the yield point of a given area.
Patent CA-3203426-A1 (CA)
Inventor: FAN CHUAN
IPC: G01V1/40
Filed: 2021-11-10
Abstract: Procédé de calcul de temps de transit d'intervalle. Le procédé consiste : à déterminer des limites de domaine temporel de différents types de signaux d'onde dans des signaux d'origine d'un point de profondeur cible pré-acquis (101) ; à extraire des signaux d'onde cibles du point de profondeur cible à partir des signaux d'origine du point de profondeur cible en fonction des limites de domaine temporel des différents types de signaux d'onde dans les signaux d'origine du point de profondeur cible (102) ; à calculer des informations de domaine fréquentiel et des informations de domaine temporel des signaux d'onde cibles (103) ; et à calculer le temps de transit d'intervalle des signaux d'onde cibles au point de profondeur cible à l'aide des informations de domaine fréquentiel et des informations de domaine temporel (104).
Patent CA-3204582-A1 (CA)
Inventor: UNSWORTH JOHN FRANCIS
IPC: C25C3/12
Filed: 2022-01-26
Abstract: Processes are described for the production of a pitch for use in the manufacture of carbon composite materials. The process comprises the steps of providing a purified coal product (PCP), wherein the PCP is in particulate form, and wherein at least about 90% by volume (%v) of the particles are no greater than about 25 µm in diameter; wherein the PCP has an ash content of less than about 10%m; and combining the PCP with a feedstock for pitch to create a combined blended mixture suitable for thermal reaction followed by distillation to create a resultant pitch. The combined blended mixture comprises at least around 0.1 %m and at most around 90%m PCP. Composite materials that find utility as carbon electrodes, particularly electrolytic baked carbon anodes, can be made from combining the pitch and PCP with a filler material, such as a pet coke.
Patent CA-3204598-A1 (CA)
Inventor: PASTERIS ROBERT JAMES
IPC: A01N43/82
Filed: 2021-12-16
Abstract: Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein R1, L and J are as defined in the disclosure and (b) at least one additional fungicidal compound. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Formula 1, an N-oxide, or salt thereof (e.g., as a component in the aforesaid composition). Also disclosed is a composition comprising: (a) at least one compound selected from the compounds of Formula 1 described above, N- oxides, and salts thereof; and at least one invertebrate pest control compound or agent.