Patent SG-11201807661W-A (SG)
Title: A closed system for labelling and selecting live cells
Inventor: SMITH DAVID
IPC: C12N15/00
Filed: 2017-03-27
Abstract: 110 PRODUCT BAG & LABELING BAG (WASTE) IR LABELING WASTE) 140 170 CLOSED SYSTEM- LOOP 0 • o MICRO DEXTRAN BEADS COATED WITH ALGINATE (OPTION 2) ALGINATE BEADS OPTION 1 120 130 FINAL PRODUCT BAG 100 W O 20 17 / 15 397 4 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/153974 Al 14 September 2017 (14.09.2017) WIPO I PCT 111111111111110111011111111111010111110111011110110111111011101111111111111110111111 (51) International Patent Classification: GO1N 33/48 (2006.01) C12N 15/00 (2006.01) GO1N 33/487 (2006.01) A61K 35/00 (2006.01) C12N 5/00 (2006.01) (21) International Application Number: PCT/IB2017/051736 (22) International Filing Date: 27 March 2017 (27.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/304,781 7 March 2016 (07.03.2016) US 62/305,779 9 March 2016 (09.03.2016) US (71) Applicant: CALADRIUS BIOSCIENCES, INC. [US/US]; 420 Lexington Avenue, Suite 350, New York, New York 10170 (US). (72) Inventors: SMITH, David; 357 South Maple Avenue, Ridgewood, New Jersey 07450 (US). CHAN, Wai Shun; 150 Overlook Avenue, 14C, Hackensack, New Jersey 07601 (US). HAMPSON, Brian; 215 Bamford Avenue, Hawthorne, New Jersey 07506 (US). PRETI, Robert; 80 Nursery Road, Ridgefield, Connecticut 06877 (US). JI- ANG, Yajuan; 260 Franklin Avenue, Apartment 518, Mahwah, New Jersey 07430 (US). LEBLON, Courtney; 84 Rutgers Lane, Parsippany, New Jersey 07054 (US). (74) Agent: LUBIT, Beverly; McCarter & English LLP, 100 Mulberry Street, Newark, New Jersey 07052 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, [Continued on next page] (54) Title: A CLOSED SYSTEM FOR LABELLING AND SELECTING LIVE CELLS (57) : The described invention provides an auto- FIG. 1 mated, closed system and method for separating/isolating a target cell type from a heterogeneous cell population. WO 2017/153974 Al MIDEDIMOMOIDEIR0101311011001MOBIMMEMOIMIE RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with information concerning request for restoration of the right of priority in respect of one or more priority claims (Rules 26bis.3 and 48.2(b)(vii))