baber/WOPTO huggingface dataset:
Patent AT-E457364-T1 (AT)
Inventor: NIEHOF MONIKA
Filed: 2006-04-07
Granted: 2010-02-15
Abstract: Dysfunction of HNF4± may lead to disease and an identification of genes targeted by this factor provides insights into mechanisms of disease. In accordance with the invention thirteen new HNF4± target genes were found (C20orf13, KIAA0774, EPS15R, PLCB1, UGTREL1, RSK4, PAK5, FMR2, NEB, NFYC, KCNQ4, PRPF3, TRPC1). These genes were identified by means of molecular biological and molecular genetic methods. The genes code for various biological functions (metabolism, regulation of cell cycle and signal transduction, differentiation, ion channels, mRNA processing, see table A) and are thus important for the therapy of metabolic disorders, diabetic diseases and tumor growth.  The HNF4± target genes RSK4 and PAK5 are already reported. These genes encode kinases which are selective regulated in animal models of diabetes. The kinases RSK4 and PAK5 are of fundamental importance for the therapy of diabetic nephropathy and neuroropathy (Niehof, M. and Borlak, J. 2005, RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain,  Mol. Pharmacol.  67 604-611; European Patent application 04016948.4).  In the present invention, additionally eleven new HNF4± target genes are described.  The gene TPRC1 encodes a non-selective cation channel, which is activated via a receptor or after emptying of intracellular stores. The TPRC1-channel controls the influx of calcium into the cell. TPRC1 proteins are expressed in most cells and are the most important channels for the uptake of calcium into the cell. TPRC1 is for example expressed in the pancreas and the kidney. In the pancreas TPRC1 can support the calciumhomeostasis. A defective regulation of TPRC1 can effect the secretion of insulin.  It was shown that HNF4± and TPRC1 are regulated in animal models of diabetes. Thus, TPRC1 is a candidate gene for the treatment of diabetic nephropathy.  KCNQ4 encodes a voltage-dependent potassium channel. This channel is expressed in sensory haircells of the cochlea. The dysfuction of this channel can cause loss of hearing. Impairments in hearing are one of the symptoms caused by diabetes.  The HNF4± transcription factor targets the genes EPS15R and PLCB1, which are involved in the regulation of signal cascades. Via these genes HNF4± controls the cell cycle. It was found that the EPS15R protein binds to the EGF-receptor. This knowledge can be used to develop strategies to treat tumors.  The discovery of the above described target genes of HNF4± and their function comprises an enormous potential for the treatment of metabolic diseases including diabetes and diabetic caused diseases and tumor growth. By cooperation with pharmaceutic companies this knowledge can be excellently used to develop new straightforward strategies and outstanding agents for the simple treatment of metabolic disorders. Such agents can be, for example, drugs which affect the genes which are dysregulated due to the disease.
Patent AT-E556074-T1 (AT)
Inventor: BORDES MARIE-FRANCOISE
Filed: 2006-03-15
Granted: 2012-05-15
Abstract: The invention concerns compounds of formula I, a method for preparing said compounds, pharmaceutical compositions containing same and the therapeutic uses thereof.
Patent AT-E463055-T1 (AT)
Inventor: RIDLEY PETER JOHN
IPC: H01M8/02
Filed: 2006-04-05
Granted: 2010-04-15
Abstract: A redox fuel stack cell comprises a plurality of essentially similar half-cell frames of molded polymer; interleaved between them are semi-permeable membranes and bipolar plate electrodes. The frames are rectangular, with margins around central voids. At the voids, they have rebates in abutting faces for locating the plate electrodes. At their corners, they have apertures for forming ducts throughout the stack for flow of electrolyte to and from the cell cavities provided by the voids. The frames have electrolyte flow passages open in their faces abutting the frames and leading towards each other. The passages stop short of each other and are surrounded by grooves containing sealing O-rings. Diagonally opposite one of the passages end at openings passing through the frames. The other passages have no openings in the frames, but the frames have openings through them in register with the ends of the passages.
Patent AT-E439866-T1 (AT)
Inventor: WILLARD NICOLAAS
Filed: 2006-04-21
Granted: 2009-09-15
Abstract: The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localized inflammation respectively.
Patent AT-E467289-T1 (AT)
Inventor: LIU SHAOWEI
Filed: 2006-06-02
Granted: 2010-05-15
Abstract: A method for forwarding service in the data communication device and the forwarding apparatus, said apparatus includes a memory unit and a forwarding unit, wherein storing the Route Prefix, the private data of the Route Prefix and the corresponding Next Hop Array; said forwarding unit forwards the service at the data communication device according to said private data and the Next Hop corresponding with the Route Prefix. Using the present invention, it can implement the corresponding differentia process for the different Prefix while the data communication device is forwarding service. It also may constitute a new-style FIB using the present invention, accordingly not only improve the updating speed of FIB, save the internal memory of the data communication device, but also satisfy the requirement that the different Prefixes need to have the different private domains with some specific functions.
Patent AT-E443337-T1 (AT)
Inventor: AUMUELLER RUPERT
Filed: 2006-05-05
Granted: 2009-10-15
Abstract: The coil core (1) is produced of ferrite and is cylindrical. Wound onto this is a coil (4) with tangentially located ends (5). The coil is wound such that there is an increased spacing (7) between coil sections. A plastic retaining element is fitted to maintain the gap.
Patent AT-E538737-T1 (AT)
Inventor: GOODE LOUIS
Filed: 2006-04-14
Granted: 2012-01-15
Abstract: An entry device for providing access to the interior of a body vessel through a wall of the vessel to enable removal of an implanted structure, such as a cardiac lead, from the body vessel includes an elongated sheath member and a tip positioned at the distal end of the sheath member. The elongated sheath member and tip have respective passageways extending therethrough that are sized and aligned to receive the implanted structure therein upon accessing the vessel. The elongated sheath member is capable of delivering sufficient torque to permit advancement of the tip through a wall of the vessel. The device may include an optional handle, and may be driven by manual or mechanical action.
Patent AT-E431650-T1 (AT)
Inventor: DEROUET PATRICE
Filed: 2006-06-21
Granted: 2009-05-15
Abstract: A transmitter device for wireless communication equipment, comprises at least one path (P1) comprising i) a low-pass filter (LPF 1+, LPF1−) for filtering differential signals and applying a chosen first attenuation to each of them to decrease their amplitudes, ii) a differential transconductor (TC1+, TC1−) arranged for applying a chosen second attenuation to each differential signal coming from the low-pass filter (LPF1+, LPF1−) to decrease its continuous component, and iii) a mixer (M1) for mixing separately the differential signals delivered by the transconductor with local oscillator carriers at a chosen radio frequency to deliver output RF signals to be transmitted. The transconductor (TC1+, TC1−) comprises two original cells (OC) for defining two original signals from the differential signals having the first attenuation, and N first and N second signal copy cells (CC1-CC6) each arranged for generating a copy of one of the original signals. The number of signal copy cells used defines the second attenuation and the first and second attenuations to be applied are chosen so that the value (defined by the offset between the continuous component of the differential signals delivered by the transconductor divided by the amplitude of one of these signals) stays below a chosen maximum value over the whole gain range of the path.
Patent AT-E465043-T1 (AT)
Inventor: DEFILIPPI ROBERTO
Filed: 2006-08-03
Granted: 2010-05-15
Abstract: A fuel vapor adsorbing device has a casing having an axis and defining a vapor inlet, a vent connected to the outside environment, and a chamber connected fluidically to the inlet and the vent. The adsorbing device also includes a filter material housed in the chamber; a cover wall covering the chamber; and an elastic mechanism and, preferably, a grille, which are integral with the cover wall and cooperate with the filter material.
Patent AT-E548446-T1 (AT)
Inventor: DEORKAR NANDU
Filed: 2006-09-14
Granted: 2012-03-15
Abstract: Purification of vegetarian (non-animal derived) Protein A using a multidimensional purification process to remove undesirable non-animal derived component impurities in the Protein A from the non-animal fermentation media used to produce the Protein A so as to produce a vegetarian Protein A free of animal-origin components and essentially free of components derived from non-animal derived growth media.
Patent AT-E487481-T1 (AT)
Inventor: HANNEY BARBARA
Filed: 2006-09-22
Granted: 2010-11-15
Abstract: The invention relates to substituted N-(4-oxo-3,4-dihydroquinazolin-2-yl)butanamid derivatives which modulate androgen receptors to treat conditions such as: osteoporosis, peridontal disease, bone fracture, frailty, and sarcopenia.
Patent AT-E538098-T1 (AT)
Inventor: LUI NORBERT
Filed: 2006-11-23
Granted: 2012-01-15
Abstract: The present invention relates to a novel process for preparing known 5-fluoro-1,3-dialkyl-1H-pyrazole-4-carbonyl chlorides which can be used as starting materials for active fungicidal ingredients.
Patent AT-E515100-T1 (AT)
Inventor: PARMAKSIZ SEZGIN
Filed: 2006-12-18
Granted: 2011-07-15
Abstract: By this invention, in a motor (1) comprising a control unit (3) and a thermic protector (4) which protects the motor (1) from high temperature and current values, by estimating the state of the thermic protector (4), the startup of the motor (1) is provided by igniting the triacs (6 and 16) according to the state of the thermic protector (4).
Patent AT-E451195-T1 (AT)
Inventor: JAESCHKE BIRGER
Filed: 2007-06-30
Granted: 2009-12-15
Abstract: Impulse generator comprises switching devices (5~-6~~) arranged in a charging connection (2) to provide polarity to the charging of the ignition capacitor (1). A discharge circuit (3) provides a discharge current depending on the polarity of the charging of the ignition capacitor in a prescribed direction via a semiconductor switch (11).
Patent AT-E472397-T1 (AT)
Inventor: OHNO KAZUSHIGE
IPC: B29C48/30
Filed: 2007-10-12
Granted: 2010-07-15
Abstract: It is an object of the present invention to provide a method for manufacturing a honeycomb structured body (10,250) that can increase the number of honeycomb fired bodies (220,230,240) that can be manufactured per unit time, and a method for manufacturing a honeycomb structured body (250) of the present invention comprises the steps of: extrusion-molding a raw material composition (50) containing ceramic powder and a binder to manufacture a coupled honeycomb molded body (300,400) having a shape in which a plurality of pillar-shaped honeycomb molded bodies, each having a large number of cells (21,241,321) disposed in parallel with one another in a longitudinal direction with a cell wall (22,242) therebetween, are integrated with one another by interposing a coupling portion (324,424); firing the coupled honeycomb molded body (300,400) to manufacture a coupled honeycomb fired body (100); cutting the coupling portion (324,424) of the coupled honeycomb fired body (100) to manufacture a plurality of coupling-portion-cut honeycomb fired bodies (20); and binding a plurality of honeycomb fired bodies (220,230,240) by interposing an adhesive layer (254), at least one of the plurality of honeycomb fired bodies (220,230,240) being a coupling-portion-cut honeycomb fired body (20).
Patent AT-E475559-T1 (AT)
Inventor: SIGNORETTO CARLO
Filed: 2007-11-15
Granted: 2010-08-15
Abstract: An automatic release system (1) for a rolling element (2) for the passenger compartment of a vehicle such as a separator between passenger compartment and baggage compartment or a sun blind, wherein the rolling element presents a first side operatively connected to a rigid support (7) fixable to the vehicle bodywork and within which the element is rolled under the bias of elastic return means (6), and a second side opposite to the first and connected to an essentially rigid bar (11) arranged parallel to the support and relatively mobile with respect to the same, fixable in releasable manner to the bodywork in distal position from the support by means of attachment means including anchoring means (14) carried by the vehicle bodywork and retaining means (15) integrally carried by opposite ends (16) of the bar protruding from opposite sides of the separating element and restrainable in use to the anchoring means; wherein the retaining means include at least one tooth (30) hinged to the bar about a first axis (A) parallel to the first and second side; and bistable return means (32) adapted to selectively force the tooth, in consequence of a relative rotation of the bar about a second axis (C) parallel to the first, towards a first and a second stopper position in which the tooth (30) is adapted to respectively engage or not engage the engaging means (33) of the anchoring means (14).
Patent AT-E492709-T1 (AT)
Inventor: DUROCHER CLAUDE
IPC: E21B47/04
Filed: 2007-11-22
Granted: 2011-01-15
Abstract: A borehole apparatus capable of autonomously estimating its position in a borehole and controlling the actions of a downhole tool, the apparatus comprising: 
a body; 
at least one measurement device; 
a computer system located in the body, 
a power system; 
wherein the computer system is configured to process the data gathered from the measurement device to estimate the position of the downhole device using a Bayesian approach and configured to provide output signals to control an action of the downhole tool dependent on the position of the apparatus in the borehole.
Patent AT-E447169-T1 (AT)
Inventor: GRINON RAPHAEL
Filed: 2007-02-20
Granted: 2009-11-15
Abstract: The device includes means for holding a support (19) adapted to retain microorganisms in a predetermined position in which a first face (10) of said support (19) is in a first predetermined location and a second face (11) of said support (19) is in a second predetermined location, a station (2) for spraying onto said support (19) a reagent for revealing the presence of ATP by luminescence, said station (2) facing said first location, and a station (4) for measuring said luminescence opposite the spraying station and facing said second location.  The method includes the step of procuring a device of the above kind, the step of disposing said support (19) at said predetermined location, the step of spraying said reagent onto said support (19) and, simultaneously with the spraying step, the step of measuring the quantity of light emitted in response to said reagent.
Patent AT-E480999-T1 (AT)
Inventor: VERHOVNIK GLENN
IPC: A23L27/00
Filed: 2007-02-01
Granted: 2010-10-15
Abstract: A process for the preparation of powder products via spray-drying, in a generally known manner, of aqueous dispersions, or slurries, of aminoplast microcapsules comprising an encapsulated oil, wherein, prior to being submitted to spray-drying, there is added to said slurry a de-tackifying colloid in an appropriate amount and the pH of the slurry thus obtained is adjusted to a value comprised between 4 and 6 by means of an acid. This process makes it possible to obtain powders that are particularly useful to impart pleasant and useful properties, namely fragrance and antibacterial or malodor counteracting properties, to consumer products wherein the incorporation of aqueous media or compositions is undesirable and affects the physical structure of the consumer product.
Patent AT-E497888-T1 (AT)
Inventor: KIWAKI YUKIHIRO
Filed: 2007-02-20
Granted: 2011-02-15
Abstract: A pneumatic tire according to the present invention includes blocks on its tread which are segmented by plural circumferential grooves 3 extending along a tire circumferential direction and plural lateral grooves 5 extending along a tread width direction. Circumferential sipes extending along the tire circumferential direction are provided in the blocks. Inside circumferential sipes extend straight along a tire radial direction and outside circumferential sipes extend along the tire radial direction in zigzag patterns. According to the present invention, a handling performance, especially, a cornering performance can be improved regardless of road surface conditions.
Patent AT-E490257-T1 (AT)
Inventor: BUSOLLI JONATHAN
Filed: 2007-08-14
Granted: 2010-12-15
Abstract: This invention relates a crystalline form of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, pemetrexed diacid, and to a process for the preparation thereof.
Patent AT-E513235-T1 (AT)
Inventor: YEO BOON
Filed: 2007-09-20
Granted: 2011-07-15
Abstract: A solar control member for determining solar control for a window includes an optically massive layer between a gray metal layer and a titanium nitride layer. The optically massive layer has sufficient thickness to retard or prevent constructive and destructive interference of reflected light. The optically massive layer may be an adhesive, but also may be one or more polymeric substrates. The gray metal layer is preferably nickel chromium, but other gray metal materials provide superior results as compared to the prior art. Also in the preferred embodiment, the titanium nitride layer is closer to the window (e.g., glass) than the gray metal layer.
Patent AT-E487848-T1 (AT)
Inventor: RIEDER OTTO
Filed: 2008-06-20
Granted: 2010-11-15
Abstract: The device (10) has a drilling carriage (50) guided along a mast (23) in a displaceable manner, and a drive unit provided with a hydraulic cylinder drive and a rope winch drive (30), and utilized for moving the carriage on the mast. The drilling carriage is connected alternately with the hydraulic cylinder drive and the rope winch drive through a coupling device. The mast includes a telescopic mast element (26) and a mast base element (24) that is coupled with the hydraulic cylinder drive. The drilling carriage includes a guide (54) for guidance along the mast base element. An independent claim is also included for a deep-hole drilling method.
Patent AT-E529203-T1 (AT)
Inventor: RAHM MANFRED
Filed: 2008-07-29
Granted: 2011-11-15
Abstract: The hammer (12) has a percussion surface (13) for shaping a work piece (10') at different contact points (KP, KP', KP'') of the percussion surface. The percussion surface includes a concave curve section in a normal plane of a longitudinal axis of the hammer. The curve section is varied between a crown line (26') of the percussion surface and edge regions of the surface. Each contact point exhibits a curve radius (R) defining a circle of curvature with middle points (M, M', M''). The middle points lie in a middle symmetry plane (24) extending along the axis and contain the crown line.
Patent AT-E474370-T1 (AT)
Inventor: LACOMBE BERTRAND
Filed: 2008-02-08
Granted: 2010-07-15
Abstract: The converter has primary and secondary windings (Lp, Ls) coiled around a single magnetic core and including sets of ends that are connected to a branches' mid-point, an output terminal (SP) and a mass, respectively. Parts of one of the ends connect its mid-point to respective positive voltage (Vp) i.e. +25 volt, and a negative voltage (Vm) i.e. -25 volt. The parts have interrupter forming units (Q1, Q2) e.g. bipolar transistors, and diodes (D3, D4) that are set directly with respect to the voltages and form a unidirectional interrupter to ensure direct and inverse blocking of the diodes. An independent claim is also included for a method of operating a chopping converter.
Patent AT-E526750-T1 (AT)
Inventor: BRETHEREAU ALAIN
Filed: 2008-02-21
Granted: 2011-10-15
Abstract: The device (D) has a processing unit (MT) arranged to determine a stable object in a memorization unit (MM), and order an application of a set of values to a parameter to be adapted in an identified object. The processing unit is used to analyze an influence of adaptation of the parameter on the operation of the identified object to not replace an old definition of characteristics of the identified object by the definition of characteristic adapted in the memorization unit in case of improving operation induced by the adaptation of the parameter.
Patent AT-E470325-T1 (AT)
Inventor: SHI GUANGYU
Filed: 2008-12-18
Granted: 2010-06-15
Abstract: In order to overcome the shortcomings caused by the centralized type user data management in telecommunication network, the invention realizes a high efficiently communication network distributed type data management system by improving the Distributed Hash Table (DHT) technique and applying to user data management of communication network and overcomes the shortcomings of the original centralized type data management. A method for storing communication network user data based on DHT comprises the steps of: receiving to-be-stored user data by a first node in a DHT superposing network, using the to-be-stored user data as back-up data and dividing into L/K parts, and respectively storing the to-be-stored user data as main data and K*L/L parts of divided back-up data in 1+K*L/L DHT nodes, wherein L is more than or equal to a ratio between a downlink bandwidth of a second node in the DHT superposing network and an uplink bandwidth used for recovering data, and K is the total parts of the back-up data and is an integer more than zero.
Patent AT-E470968-T1 (AT)
Inventor: OTTO NACHBAUER
Filed: 2008-03-06
Granted: 2010-06-15
Abstract: The coupling part has electrical contacts (2, 3) insulated against each other, and connected with electrical lines (4, 5) of an electrical conductor (6). The conductor has two wires (7, 8) enclosed by a common casing (9). A clamping unit made of mechanically stable insulating material is attached around a projection (10) of a contact holder (1). The unit is attached to the projection in an installed position, and is clamped to the wires between half shells (14) of the unit. A protection unit (15) produced by injection molding is attached to the clamping unit, and extended over the casing.
Patent AT-E487509-T1 (AT)
Inventor: SHAN NICOLAS
Filed: 2008-09-18
Granted: 2010-11-15
Abstract: The tool (10) has a holding pathway for a lead (82) i.e. cardiac lead, placed in a prehension area, where the holding pathway includes a curved area crossing through a concave footprint (34) and in continuation of a straight tubular guide and following an overall orientation presenting an angle with the tubular guide. The holding pathway includes an S-shaped pathway provided with a curved area and counter-curved area. The tubular guide is placed roughly parallel to a cutting direction. The tubular guide receives the lead at an open side and receives a guide-catheter (84) at a blade side.
Patent AT-E484546-T1 (AT)
Inventor: HANEFELD PHILLIP
Filed: 2008-06-19
Granted: 2010-10-15
Abstract: A description is given of a semi-interpenetrating network having a first phase of a linear noncrosslinked isobutene polymer and a second phase of a crosslinked polymer, wherein the crosslinked polymer is obtained by crosslinking molecular enlargement reaction in the presence of the isobutene polymer. The crosslinked polymer is preferably obtained by free-radical polymerization of ethylenically unsaturated monomers comprising at least one polyethylenically unsaturated monomer. The networks are suitable as molding compounds having gas and moisture barrier effect or as adhesives.