Patent SG-11201811151P-A (SG)
Title: Extracellular vesicle comprising a fusion protein having fc binding capacity
Inventor: WIKLANDER Oscar
IPC: A61K39/395
Filed: 2017-07-21
Abstract: Fcbinder domain Exosomal protein 'Lipid bilayer () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 January 2018 (25.01.2018) WIPO I PCT IiiimmoimiolollmonoloommonummomovoimIE (10) International Publication Number WO 2018/015535 Al (51) International Patent Classification: A61K 39/395 (2006.01) (21) International Application Number: PCT/EP2017/068476 (22) International Filing Date: 21 July 2017 (21.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1612643.5 21 July 2016 (21.07.2016) GB (71) Applicant: EVOX THERAPEUTICS LTD [GB/GB]; 2nd Floor, King Charles House, Park End Street, Oxford OX1 1JD (GB). (72) Inventors: WIKLANDER, Oscar; Greta Garbos vag 21B, 16940 Solna (SE). GORGENS, Andre; Domarvagen 18, Huddinge, SE-14162 (SE). GUPTA, Dhanu; Myrstuguva- gen 147, Varby, Huddinge, 143 32 Stockholm (SE). (74) Agent: COOLEY (UK) LLP; Dashwood, 69 Old Broad Street, London, Greater London EC2M 1QS (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) = (54) Title: EXTRACELLULAR VESICLE COMPRISING A FUSION PROTEIN HAVING FC BINDING CAPACITY (57) : The present invention pertains to extracellular vesicle (EV) therapeutics, wherein the EVs are coated with proteins containing Fc domains (such as antibodies) for i.a. targeting and therapeutic applications. The coating of EVs is achieved through inventive protein engineering of EV polypeptides. The present invention thus relates to methods for coating of EVs, EVs per se, as well as pharmaceutical compositions and medical applications of such EVs coated with Fc containing proteins. Lumen Extracetlular vesicle Figure 1 W O 20 18/0 155 35 Al