baber/WOPTO huggingface dataset:
Patent DE-69331806-D1 (DE)
Inventor: CHEN CHIH-MING
IPC: A61K9/50
Filed: 1993-06-03
Granted: 2002-05-16
Abstract: PCT No. PCT/US93/05922 Sec. 371 Date Jun. 13, 1994 Sec. 102(e) Date Jun. 13, 1994 PCT Filed Jun. 3, 1993 PCT Pub. No. WO94/28882 PCT Pub. Date Dec. 22, 1994.A unit dosage form of capsule, tablet or the like is composed of a large number of pellets made up of two or more populations of pellets or particles. Each pellet contains a core containing the therapeutic drug and a water soluble osmotic agent. A water-permeable, water-insoluble polymer film encloses each core. Incorporated into the polymer film is a hydrophobic, water insoluble agent which alters the permeability of the polymer film. The film coating of each population of pellets differs from the coating of every other population of pellets in the dosage form in the rate at which water passes through to the core and the rate at which drug diffuses out of the core. The osmotic agent dissolves in the water, causing the pellet to swell and regulating the rate of diffusion of drug into the environment of use. As each population of pellets releases its drug into the environment sequentially, the effect is to provide a series of pulsatile administrations of the drug from a single dosage form.
Patent DE-69332147-D1 (DE)
Inventor: WEISS SAMUEL
IPC: A61K35/30
Filed: 1993-10-15
Granted: 2002-08-29
Abstract: A method for the remyelination of neurons is disclosed wherein neural stem cells isolated from adult or fetal neural tissue are proliferated in a culture medium containing a growth factor to produce precursor cells having a nestin (+) phenotype. The precursor cells are capable of differentiation into oligodendrocytes which, when associated with a demyelinated neuron, effect remyelination.
Patent DE-69404031-D1 (DE)
Inventor: PICARD ANTOINE
IPC: B62D53/00
Filed: 1994-04-19
Granted: 1997-08-07
Abstract: PCT No. PCT/FR94/00440 Sec. 371 Date Nov. 29, 1995 Sec. 102(e) Date Nov. 29, 1995 PCT Filed Apr. 19, 1994 PCT Pub. No. WO94/23985 PCT Pub. Date Oct. 27, 1994The articulated vehicle is formed from a plurality of modules interconnected in an articulated fashion, including one leading module (1) with a front steering set of wheels (12), a rear module (3) with a controlled orientable rear set of wheels (13) and, optionally, one or more intermediate modules (2), a vehicle wherein two successive modules are connected by a movable articulation support (6, 7) carried by an axle and duplicated by a rigid oblique articulated connection (8,9), the orientation of each movable articulation support (6, 7) and that of the rear orientable wheel set (13) being controlled in such a way that its transverse median axis corresponds at all times to the bisector of the angle formed by two successive modules.
Patent DE-69404177-D1 (DE)
Inventor: POZZOBON ALESSANDRO
IPC: A63C17/14
Filed: 1994-01-17
Granted: 1997-08-21
Abstract: Braking device particularly usable for skates including a shoe (3) composed of at least one quarter (4) articulated to a shell (5) associated with a supporting frame (6) for two or more wheels (7). The device includes a rod member (8) which is connected to a braking element (12) and has a kinematic system (13) suitable to allow the rotation of the quarter without activating the braking element, so as to allow to deactivate the braking element while skating or allow rear-entry insertion of the foot if the skate is of the rear-entry type. A locking element is provided for locking the kinematic system and/or the devices for deactivating the braking element. <IMAGE>
Patent DE-69404448-D1 (DE)
Inventor: OLSON KEITH
IPC: C11D17/08
Filed: 1994-01-06
Granted: 1997-08-28
Abstract: Aqueous bleach solutions can be made by directing a spray of water onto a bulk or shaped solid (brick, tablet, block, etc.) comprising a continuous solid phase of an encapsulated source of an active halogen bleach or a solid comprising a source of an oxidizing active halogen bleach, and an encapsulated oxidizing halogen bleach source. Such shaped solids can be used to dispense an aqueous bleach concentrate to bleaching locus such as a washing machine.
Patent DE-69404853-D1 (DE)
Inventor: COALIER GUY
IPC: B65D5/475
Filed: 1994-10-18
Granted: 1997-09-11
Abstract: PCT No. PCT/FR94/01208 Sec. 371 Date Jul. 18, 1996 Sec. 102(e) Date Jul. 18, 1996 PCT Filed Oct. 18, 1994 PCT Pub. No. WO95/11165 PCT Pub. Date Apr. 27, 1995A carton has a bottom, side walls and top. A strap handle is attached to both sidewalls and extends over the top. The handle fits into slots that extend from the side wall into the top. The handles are attached to the side wall below these slots. The ends of the slots have enlarged areas that retain the handle as it extends through the slot. The enlarged areas can be any number of different shapes.
Patent DE-69406605-D1 (DE)
Inventor: GELMETTI CARLO
IPC: B65D5/46
Filed: 1994-02-21
Granted: 1997-12-11
Abstract: PCT No. PCT/EP94/00493 Sec. 371 Date Oct. 17, 1994 Sec. 102(e) Date Oct. 17, 1994 PCT Filed Feb. 21, 1994 PCT Pub. No. WO94/19258 PCT Pub. Date Sep. 1, 1994.Container or box for packaging and unwinding a coil (18) of wire (2), which comprises: a box-like body (5, 11) that has a polygonal plan, can be opened at the top and is meant to accommodate a coil for wire; and a coil covering panel (16) that has a central circular opening (17) and a contour that matches the plan shape of the box-like body, so that it can freely descend within the box-like body in contact with the coil as the height of the coil decreases as the wire is unwound from above through the central opening of the panel, in order to prevent the lifting of turns of wire between the peripheral region of the panel and the container and thus the accidental entanglement of turns.
Patent DE-69408533-D1 (DE)
Inventor: FERGUSON PAUL
IPC: H03M3/02
Filed: 1994-04-06
Granted: 1998-03-19
Abstract: A switched capacitor one-bit digital-to-analog converter is preferably utilized in the feedback path of a sigma delta modulator. The one-bit digital-to-analog converter includes first and second capacitors, a first switching circuit for coupling charge from a reference source to the capacitors, and a second switching circuit for coupling charge from the capacitors to positive and negative outputs, such as the summing junction of an operational amplifier. The switches in the second switching circuit have a cross-coupled configuration and are controlled by data dependent control signals. The data dependent control signals are structured such that charge is coupled from the capacitors to the summing junction on both clock phases, regardless of the state of the data. As a result, the sizes of the capacitors can be reduced by a factor of two for the same charge transfer.
Patent DE-69416046-D1 (DE)
Inventor: OHLSSON THOMAS
IPC: G06F17/00
Filed: 1994-06-20
Granted: 1999-03-04
Abstract: In a method for enhancing the signal-to-noise ratio of ECG signals, A/D-converted signals from a plurality of cardiac cycles are time-synchronized to form a signal ensemble, whereupon the concordance between the signals in the ensemble is determined in time intervals, comprising at least two samples, during at least a part of the cardiac cycles. A device for enhancing the signal-to-noise ratio of ECG-signals, comprises means (4, 5) for recording, A/D-converting and other processing of the ECG-signals. A synchronization unit is arranged to time-synchronize the signals from a plurality of cardiac cycles to form a signal ensemble, and a calculator unit (12) controlled by a window unit is arranged to determine the concordance between the signals in the ensemble in time intervals, comprising at least two samples, during at least a part of the cardiac cycles. <IMAGE>
Patent DE-69424403-D1 (DE)
Inventor: LUSARDI ADRIANO
IPC: B32B17/12
Filed: 1994-09-29
Granted: 2000-06-15
Abstract: A fireproof panel is described which comprises at least one sheet including a layer of glass fibres impregnated with at least one fireproof resin free from solvent. A method for the manufacture of this panel is also described and includes the successive steps of distributing a fireproof resin in the form of a powder free from solvents on a layer of glass fibres, subjecting the latter to a first compression and heating step to soften the resin and to a second compression and heating step to cross-link the resin and form the said sheet.
Patent DE-69431064-D1 (DE)
Inventor: COUNTS W
IPC: C14C1/06
Filed: 1994-11-08
Granted: 2002-08-29
Abstract: Wet leather treating compositions and methods of wet treating leather hides employing alkylpolyglycosides for enhancing the penetration and absorption of the leather treatment formulations in an environmentally safe manner. The compositions are substantially free of volatile organic compounds.
Patent DE-69514607-D1 (DE)
Inventor: UNNO TOMOKO
IPC: C12Q1/58
Filed: 1995-10-09
Granted: 2000-02-24
Abstract: A method for stabilizing urease in an assay reagent for determination of urea nitrogen in a sample and a method for accurately determining urea nitrogen in a sample are disclosed. After urea nitrogen in the sample is reacted with urease in the presence of an organic boron compound, the amount of ammonia formed by the reaction is determined.
Patent DE-69525369-D1 (DE)
Inventor: BREARLEY MARION
IPC: C08G69/26
Filed: 1995-11-16
Granted: 2002-03-21
Abstract: The invention provides a continuous process for the preparation of polyamides, equipment in which the polymerization process can be conducted, and process control methods for said polymerization process.
Patent DE-69534361-D1 (DE)
Inventor: GRIECO PAUL A
IPC: A01N65/00
Filed: 1995-11-03
Granted: 2005-09-08
Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells. <IMAGE>
Patent DE-69603077-D1 (DE)
Inventor: BURGESS LESTER E
IPC: H01H3/14
Filed: 1996-04-23
Granted: 1999-08-05
Abstract: A pressure actuated switching apparatus comprises an elastomeric first conductive layer (17b), a second conductive layer (12), a layer of electrically conductive compressible piezoresistive material (14) and at least one electrically insulative spacer element (13). Said layer of electrically conductive compressible piezoresistive material (14) has first and second surfaces, the first surface being in electrically contacting relationship with the elastomeric first conductive layer (17b). The piezoresistive Material (14) has an electrical resistance which varies in response to the amount of force applied thereto. The at least one electrically insulative spacer element (13) has a thickness of from about 1/32 inch to about 1/4 inch. It is positioned between the second surface of the compressible piezoresistive material (14) and the second conductive layer (12). The spacer element (13) possesses a plurality of openings (13a), each opening (13a) having a diameter of from about 1/16 inch to about 1/2 inch. In response to a force applied thereto the compressible piezoresistive material (14) disposes itself through at least some of the openings (13a) of the spacer element (13) to make electrical contact with the second conductive layer (12). <IMAGE>
Patent DE-69610124-D1 (DE)
Inventor: KATELEY ARTHUR
IPC: B65D51/20
Filed: 1996-12-16
Granted: 2000-10-05
Abstract: This invention relates to a method of creating a seal for a container with a transparent film. This method has particular application to the use of thin films with rings that form the top of a can. Embodiments of the invention that incorporate a gas indicator into the seal are also discussed.
Patent DE-69617425-D1 (DE)
Inventor: SISTI J
IPC: C07D305/14
Filed: 1996-06-07
Granted: 2002-01-10
Abstract: An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process includes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs with variable A-ring side chain structures. A rapid and highly efficient esterification of O-protected isoserine and 3-phenylisoserine acids having N-benzyoloxycarbonyl groups to the C-13 hydroxyl of 7-O-protected baccatin III is followed by a deprotection-acylation sequence to make taxol, celphalomanninne and various analogs, including photoaffinity labeling candidates.
Patent DE-69621259-D1 (DE)
Inventor: LAXVIK LARS
IPC: A61B17/50
Filed: 1996-03-12
Granted: 2002-06-20
Abstract: The invention concerns a method and device for removing ticks from humans and animals. The device comprises: a base part (1) with at least one opening (2a, 2b), a thread loop (6) of resilient material which is arranged to be drawn into the opening (2a, 2b) under the effect of a spring member (5). The cross section of this opening relative to the thread loop (6) is such that the loop (6) outside the opening (2a, 2b), whilst being drawn thereinto, gradually decreases in size. Operatively connected to the thread loop (6) is a member (4, 4a) arranged such that, against the effect of the spring member (5), it shoots the thread loop (6) out of the opening (2a, 2b). According to the method of the invention, owing to pressure being exerted on the pushbutton (4a), the loop (6) is ejected from the opening (2a, 2b), laid around the tick and, since pressure is no longer exerted on the pushbutton (4a), can be drawn into the opening (2a, 2b). The loop (6) is then rotated one turn and the tick releases its grip within approximately three seconds.
Patent DE-69629114-D1 (DE)
Inventor: SHALABY SHALABY W
IPC: C07H5/04
Filed: 1996-05-24
Granted: 2003-08-21
Abstract: A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
Patent DE-69637301-D1 (DE)
Inventor: WATSON STEPHEN R
IPC: B65D77/04
Filed: 1996-01-30
Granted: 2007-12-06
Abstract: This invention is directed to an efficient cryopreservation package design of harvested mammalian tissues and living cultured tissue equivalents made by in vitro technology. The invention involves immersing a mammalian tissue or cultured tissue equivalent in a cryoprotectant solution, agitating the cryoprotectant solution and the immersed tissue to achieve effective penetration of the cryoprotectant solution into the tissue, and then freezing the tissue at a very slow freezing rate. In the freezing step, extracellular ice formation is initiated by seeding. The cryopreserved tissue may be stored for indefinite periods of time prior to use. The cultured tissue equivalent is an in vitro model of the equivalent human tissue, such as skin or cornea, which, when retrieved from storage can be used for transplantation or implantation in vivo or for screening compounds in vitro. <IMAGE>
Patent DE-69706772-D1 (DE)
Inventor: TANAKA KENICHI
IPC: B29L5/00
Filed: 1997-06-13
Granted: 2001-10-25
Abstract: Each of bases for fusing a snap-zipper male member and a snap-zipper female member, comprising of a snap zipper, onto a bag body is formed from a mixture of polypropylene and an ethylene copolymer obtained by copolymerizing ethylene and  alpha -olefin having a carbon atom ratio of 3 to 20, in which the ethylene copolymer has a weight average molecular weight/number average molecular weight of less than 3, the density of a range from 0.850 g/cm<3> to 0.935 g/cm<3>, a melt index of a range from 0.3 g/10min, to 15 g/10min., and the range of the number of branching dependent on molecular weight of 0-5 branches/1,000 carbon. A bag with the snap zipper is structured to fuse the snap zipper through the bases onto the bag body. <IMAGE>
Patent DE-69709022-D1 (DE)
Inventor: ROBERT PATRICE M
IPC: B32B27/32
Filed: 1997-10-03
Granted: 2002-01-24
Abstract: Method for preparation grafted thermoplastic polymers is claimed, in which thermoplastic polymer (A) is grafted with functional monomer in presence of substance which inhibits or reduces crosslinking or depolymerisation of (A). Also claimed are grafted polymers made by said method; mixture of polymers containing polymers made by the method; use of the polymers as coextrusion binders; and multilayer structure containing the binder.
Patent DE-69711954-D1 (DE)
Inventor: BOSSONEY LUC
IPC: F02D45/00
Filed: 1997-01-16
Granted: 2002-05-23
Abstract: An electric vehicle drive system has several asynchronous electrical machines (11,12) each coupled to drive wheel (13,14), a polyphase supply unit (2) and a regulator (6) which uses a reference signal (SR) which represents the speed of one of the wheels. In traction mode each wheel is continually monitored for slip. If one wheel slips and at least another doesn't a speed signal (NM1,NM2) is selected for the non slipping drive wheel which turns the quickest, or if all the wheels slip a change signal (NF1) is used to produce the reference signal (SR). This first change signal represents the speed of a drive wheel immediately before it starts to slip. In the braking mode, where the electrical machines are driven by the wheels each wheel is continually monitored for locking. In the selection stage if at least one wheel is locked a speed signal is selected (NM1,NM2) which corresponds to the drive wheel which turns the quickest. If all the wheels are locked a second change signal (NF1) is used to produce a reference signal (SR) which represents the speed of a drive wheel immediately before locking.
Patent DE-69719723-D1 (DE)
Inventor: FRANSEN RENE
IPC: A01K1/12
Filed: 1997-07-21
Granted: 2003-04-17
Abstract: The invention relates to an implement for milking animals, such as cows, provided with a milking robot including a robot arm (14; 26) which is adapted to carry teat cups (21), characterized in that there is disposed a pivotable camera on the robot arm (14; 26). <IMAGE>
Patent DE-69721358-D1 (DE)
Inventor: CULLINAN GEORGE JOSEPH
IPC: A61K31/4523
Filed: 1997-02-19
Granted: 2003-06-05
Abstract: The present invention provides a class of substituted benzoÄ bÜ thiophene compounds of the structure <CHEM> and pharmaceutical compositions comprising the compounds useful, either alone or in combination with estrogen or progestin, in the symptomatic treatment of post-menopausal syndrome, particularly osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer.
Patent DE-69728280-D1 (DE)
Inventor: MCGRATH D
IPC: A61F13/40
Filed: 1997-07-07
Granted: 2004-04-29
Abstract: A unit dose chlorhexadine gluconate (CHG) applicator is disclosed wherein a unit dose of the CHG is contained in a hermetically sealed manually crushable glass ampule that has an internal volume not significantly greater than the unit dose volume of the CHG. The CHG in the ampule has an effective shelf life of at least 24 months. The glass ampule of the applicator is preferably protected by a flexible cover to protect the user's hand during manual crushing of the ampule to release the CHG therefrom. In one embodiment of the invention, a cylindrical glass ampule is housed within a tubular, flexible synthetic resin cover which has a porous applicator swab at one end thereof. Upon crushing of the glass ampule, the CHG released therefrom impregnates the swab allowing the user to spread the CHG across an area to be sanitized. In a second embodiment of the invention, a cylindrical glass ampule is received within a semi-cylindrical, open-sided body cover having a flange portion that mounts a sponge-like swab communicating with the interior of the body cover. Opposed integral wing-like gripping members on the ampule permit the user to crush the ampule by squeezing the members toward one another whereupon the CHG is released from the ampule and impregnates the sponge swab. The swab soaked with the CHG antiseptic may be rubbed across an area to be sanitized.
Patent DE-69734988-D1 (DE)
Inventor: PARIKH INDU
IPC: A61K9/51
Filed: 1997-03-28
Granted: 2006-02-02
Abstract: Composition (I) of microparticles of a water-insoluble substance comprises particles of an industrially useful water-insoluble or poorly soluble compound (i), a phospholipid (ii) and at least one non-ionic, anionic or cationic surfactant (iii) where (iii) provide volume-weighted mean particle size values of the water-insoluble compound at least 50% smaller than particles produced without (iii) using the same energy input.
Patent DE-69803303-D1 (DE)
Inventor: ENDRICI GIORGIO
IPC: A61K31/075
Filed: 1998-08-27
Granted: 2002-02-21
Abstract: In the literature, a correlation between the inhibition of 5-lipoxygenase and anti-inflammatory and immunomodulatory activity sufficient to effectively treat psoriasis, is known. It seems that, in particular, the excellent results can be obtained with lonapalene (6-chloro-2,3-dimethoxynaphthalendioldiacetate). However, the clinical use of lonapalene has not been successful most likely due to the significant number of side effects. With these considerations, after various studies, we have identified a molecule which we have patented with the name of endipalene, which seems to guarantee notable therapeutic results without side effects.
Patent DE-69806236-D1 (DE)
Inventor: GROTHER LEON
IPC: A61K9/00
Filed: 1998-02-12
Granted: 2002-08-01
Abstract: This invention relates to a process for the preparation of an oral solid rapidly disintegrating dosage form of a pharmaceutically active substance which has an unacceptable taste which process comprises: (i) forming a solution or a suspension in a solvent of a water soluble or water dispersible carrier, a filler and the pharmaceutically active substance with the unacceptable taste in association with a lipid, the weight ratio of the pharmaceutically active substance to the lipid being in the range of from 1:1 to 1:10 and the weight ratio of the carrier to the lipid being in the range of from 5:1 to 1:15; (ii) forming discrete units of the suspension or solution; and (iii) removing the solvent from the discrete units under conditions whereby unit dosages are formed comprising a network of carrier/filler carrying a dosage of the pharmaceutically active substance in association with the lipid; oral solid rapidly disintegrating dosage forms prepared by such a process are also provided.
Patent DE-69814420-D1 (DE)
Inventor: BRYANS STEPHEN
IPC: C07C229/28
Filed: 1998-08-11
Granted: 2003-06-12
Abstract: This invention is novel processes for the stereoselective preparation of gabapentin analogues.
Patent DE-69829066-D1 (DE)
Inventor: VAN GRINSVEN FRANCISCUS
IPC: B01D53/14
Filed: 1998-10-26
Granted: 2005-03-24
Abstract: A process for the purification of an aqueous alkanolamine which process comprises subjecting the alkanolamine to distillation process carried out in one or more film-type evaporators and comprising at least two steps, wherein in the first step water is removed from the aqueous alkanolamine and in the second step the de-watered alkanolamine is further purified.
Patent DE-69832520-D1 (DE)
Inventor: VANDEN HEUVEL P
IPC: A23L1/30
Filed: 1998-12-11
Granted: 2005-12-29
Abstract: Methods of treating diabetes in an animal and food compositions useful for treating diabetes are described. In one aspect of the invention, the method includes treating the animal with a therapeutically effective amount of CLA including 9,11-octadecadienoic acid and 10,12-octadecadienoic acid, isomers thereof, esters thereof, salts thereof or mixtures thereof. In another aspect of the invention, a food composition comprising a food product having a therapeutically effective amount of a purified CLA isomer, including cis,cis-9,11-octadecadienoic acid, trans,cis-10,12-octadecadienoic acid or a mixture of purified cis,trans-9,11-ocatadecadienoic acid and trans,cis-0,11-octadecadienoic acid is described.