Patent GB-956241-A (GB)
Title: New metal complexes of 1,10-phenanthrolines or bipyridines
IPC: C07D213/22
Filed: 1961-01-25
Abstract: The invention comprises metal complexes (M Chel3)Xn or (M Chel2)Xn wherein M represents a manganese (II) cobalt (II or III) copper (II), nickel (II), ruthenium (II), osmium (II), platinum (II), palladium (II), rhodium (III) and iridium (III); Chel represents a ligand provided by a substituted 1,10-phenanthroline or 2,21-bipyridine, the substituted 1,10-phenanthroline having substituents or a mixture of substituents selected from alkyl, phenyl, tolyl, and xylyl in one to six of the 3-, 4-, 5-, 6-, 7-, and 8-positions and the 2.21-bipyridine having similar substituents in one to four of the 4-, 5-, 41-, 51-positions, in the case of the phenanthroline the substitution being in one to six of the specified positions with the alkyl group or in one or two of the specified positions with the phenyl, totyl and xylyl groups, such alkyl mono-, di- and tetra-substituents totalling from four to fourteen carbon atoms and where disubstitution involves the 3-, 4-, and 7-, 8-positions either pair of carbon atoms may form part of 5-or 6-membered cycloalkane ring systems, such alkyl tri-substituents totalling from three to fourteen carbon atoms, such alkyl penta substituents totalling from five to fourteen carbon atoms such hexa-substituents totalling from six to fourteen carbon atoms and such phenyl, tolyl and xylyl mono- and disubstituents totalling from six to sixteen carbon atoms, and in the case of bipyridines the substitution being in one to four of the specified positions with the alkyl group or in one or two of the 5- and 51-positions with the phenyl, tolyl, and xylyl groups such alkyl substituents totalling from four to ten carbon atoms and such phenyl, tolyl and xylyl substituents from six to sixteen carbon atoms; X represents the anion of an organic or inorganic acid; and n an integer determined by the oxidation state of the metal and the preparation thereof by reacting together on a liquid medium a salt of the metal M with a substituted 1,10-phenanthroline or substituted 2,21-bipyridine. Where M is cobalt (III) the corresponding complex derived from cobalt (II), is oxidised in a further step and where M is ruthenium (II) or osmium (II) the phenanthroline or bipyridine is reacted under reducing conditions with a salt Z2(MX6) where Z is ammonium or an alkali metal or alkaline earth metal, M metal in valency state III or IV and X a halogen atom, a mixture of halogen atoms and hydroxyl groups or of halogen atoms and water molecules, there being at least four halogen atoms in the mixtures of X. Therapeutic compositions comprise the metal complexes of the invention together with a diluent or carrier.  Compositions may be formulated as saline solutions, creams, lotions, drops, pessaries, suppositories, tablets or lozenges for treatment of bacterial infections in humans; in carriers such as a paraffin and wax base for treatment of bovine mastitis or as solutions or suspensions useful as a drench for use in veterinary treatments; or as solutions, suspensions, emulsions, concentrates and water dispersible powders for use as plant fungicides or virocides.