baber/WOPTO huggingface dataset:
Patent CA-3056393-A1 (CA)
Inventor: CHURCH SARA ELIZABETH
IPC: A01N1/02
Filed: 2018-03-14
Abstract: The present disclosure relates to methods comprising cryogenically storing cells from a biological sample derived from a donor, in particular an apheresis sample, wherein the cells are frozen in a controlled rate freezer using a stepwise freezing profile comprising at least one step wherein the sample and/or chamber is cooled at a rate greater than 1° C per minute, and wherein the cells may comprise or be enriched for T cells. Further aspects relate e.g. to the point in time at which the cells are obtained from the donor, the storage time, shipping the cells to a storage facility before or after cryogenic freezing, the sample container being marked with codes or identifiers for cataloging the cells, administering a therapeutically effective amount of a composition comprising engineered T cells generated from the cryogenically frozen cells to a subject in need thereof; and treatment of the donor for a disease, in particular cancer.
Patent CA-3059186-A1 (CA)
Inventor: SPEARS RICHARD EARL
IPC: C09J175/14
Filed: 2017-04-14
Abstract: L'invention concerne une composition adhésive comprenant un ester vinylique cur-écorce et un acrylate d'uréthane, qui est approprié pour être appliqué sur une surface rugueuse ou irrégulière d'un substrat pour rendre une surface lisse. La présente composition adhésive est particulièrement appropriée pour revêtir de grands objets fabriqués par fabrication additive pour former des moules ou des prototypes.
Patent CA-3059230-A1 (CA)
Inventor: MORALES-ALVAREZ JORGE C
IPC: B29C48/405
Filed: 2018-04-26
Abstract: L'invention concerne une extrudeuse à tête rotative améliorée incorporant un système de vis sans fin comprenant plus d'une vis sans fin pour créer des produits extrudés asymétriques quasiment cylindriques ayant une densité dans la plage d'environ 3,0 à environ 6,0 livre/pied carré. Une large gamme de particules fines telles que de la farine et de la poudre peuvent être introduites avec succès dans une extrudeuse à tête rotative et y être transportées jusqu'à l'ensemble filière, où les matières sont cuites pour former des viroles extrudées dures et denses de formes aléatoirement asymétrique. Une pièce de transition au niveau de l'extrémité avale des vis sans fin permet un écoulement continu et uniforme vers l'ensemble filière, où la cuisson a lieu. À l'aide de l'équipement de l'invention, des matières premières autres que la semoule de maïs habituellement utilisée sont produites, la densité apparente, la texture et le broiement souhaités de produits extrudés aléatoires étant préservés.
Patent CA-3060112-A1 (CA)
Title: Engineered meganucleases specific for recognition sequences in the pcsk9 gene
Inventor: BARTSEVICH VICTOR
IPC: C12N15/63
Filed: 2018-04-20
Abstract: The present invention encompasses engineered meganucleases which recognize and cleave a recognition sequence within the human PCSK9 gene. The present invention also encompasses methods for using such engineered meganucleases in a pharmaceutical composition and in methods for treating or reducing the symptoms of cholesterol-related disorders, such as hypercholesterolemia. Further, the invention encompasses pharmaceutical compositions comprising engineered meganuclease proteins, nucleic acids encoding engineered meganucleases, and the use of such compositions for treating cholesterol-related disorders, such as hypercholesterolemia.
Patent CA-3060663-A1 (CA)
Inventor: GURUNATH ANKITA BORDOLOI
IPC: A61F2/24
Filed: 2018-04-25
Abstract: Un système de support de valvule cardiaque prothétique comprend une valvule cardiaque prothétique ayant une base au niveau d'une extrémité d'entrée, une pluralité de montants de commissure s'étendant depuis la base vers une extrémité de sortie, et des feuillets de valvule fixés aux montants de commissure pour permettre un écoulement à travers la valvule cardiaque. Un déflecteur est disposé au niveau de l'extrémité de sortie ayant un moyeu central et une pluralité de bras s'étendant à partir du moyeu central fixé à et recouvrant les pointes de montants de commissure respectifs. Un corps de support de valvule est fixé à la base et un montant relie le corps de support de valvule au moyeu du déflecteur. La pluralité de bras sont suffisamment pliables de telle sorte que, dans une première position, des extrémités libres des bras sont situées axialement entre le moyeu et le corps de support de valvule pour empêcher un bouclage de suture pendant une procédure d'implant, et dans une seconde position, le moyeu est situé axialement entre les extrémités libres des bras et le corps de support de valvule pour permettre le retrait du déflecteur du côté de sortie de la valvule, à travers les feuillets de valvule, vers le côté d'entrée de la valvule.
Patent CA-3062195-A1 (CA)
Title: Tomato hybrid drth5013 and parents thereof
Inventor: BOSCH BERNARDUS VAN DEN
IPC: A01H5/10
Filed: 2019-11-21
Abstract: The invention provides seeds and plants of tomato hybrid DRTH5013, tomato line FIR-XM16-4401, and tomato line FIR-XM17-4455. The invention thus relates to the plants, seeds, plant parts, and tissue cultures of tomato hybrid DRTH5013, tomato line FIR-XM16-4401, and tomato line FIR-XM17-4455 and to methods for producing a tomato plant produced by crossing such plants with themselves or with another plant, such as a tomato plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to plants, seeds, plant parts, and tissue cultures of tomato hybrid DRTH5013, tomato line FIR-XM16-4401, and tomato line FIR-XM17-comprising introduced beneficial or desirable traits.
Patent CA-3064070-A1 (CA)
Title: Methods of treatment for cervical dystonia
Inventor: RUEGG CURTIS L
IPC: A61K35/74
Filed: 2018-05-18
Abstract: This invention provides methods to treat or prevent cervical dystonia, a disorder related thereto, or a symptom thereof, with novel injectable compositions comprising botulinum toxin that may be administered to a subject suffering from such maledy. The injectable compositions and methods in which these compositions are used provide novel and advantageous treatments which result in high responder rates and long duration of effect, for example, a duration of effect for 24 weeks and longer.
Patent CA-3067244-A1 (CA)
Title: T-cell antigen targeted chimeric antigen receptor (car) and uses in cell therapies
Inventor: SPENCER H TRENT
IPC: A61K35/17
Filed: 2018-06-12
Abstract: This disclosure relates to engineered cells, such as T-cells, comprising targeted chimeric antigen receptors. In certain embodiments, T-cell targeted chimeric antigen receptors (CAR) are expressed at higher levels when endogenous expression of a T-cell antigen is knocked-down or reduced in the T-cells. In certain embodiments, the engineered cells are immunoregulatory cells genetically modified to prevent or reduce T-cell antigen expression, or the immunoregulatory cells contain a nucleic acid that reduces or knocks-down T-cell mRNA expression, under conditions such that reduced expression of the T-cell antigen results in an increased expression of a chimeric antigen receptor compared to similarly situated immunoregulatory cells wherein the expression of the T-cell antigen is not altered or reduced. In certain embodiments, T-cell antigens include, but are not limited to, CD5, CD7 and CD3.
Patent CA-3070895-A1 (CA)
Inventor: JACKSON TRENTON FRANK
IPC: F16K3/26
Filed: 2018-07-05
Abstract: La présente invention concerne un appareil de commande de flux de fluide destiné à être utilisé avec des vannes fluidiques. Un appareil comprend un clapet (202) pour une vanne fluidique à tige coulissante. Le clapet est doté d'une première partie (210) couplée coulissante à une seconde partie (214). L'appareil comprend également une garniture d'étanchéité (241) formée dans une surface circonférentielle externe du clapet par la première partie et la seconde partie. Une dimension de la garniture d'étanchéité change lorsque la première partie coulisse par rapport à la seconde partie pour déplacer un joint d'étanchéité placé dans la garniture d'étanchéité. Le joint d'étanchéité vient en contact d'étanchéité avec une cage (226) de la vanne fluidique lorsque la seconde partie entre en contact avec un siège (204) de la vanne fluidique.
Patent CA-3071972-A1 (CA)
Title: Heterocyclic compound and use thereof
Inventor: KAJITA YUICHI
IPC: C07D211/36
Filed: 2018-08-02
Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I) :  wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis treatment of narcolepsy.
Patent CA-3072223-A1 (CA)
Title: Surprise cup with detachable partition wall for a hidden incentive
Inventor: ABDUL QADER FAISAL
IPC: A47G19/22
Filed: 2020-02-13
Abstract: A cup, specifically incorporating a wall holder on its interior, that securely grips a sliding detachable partition wall with a closed top, to create to two separate sections. The sectionl is an enclosed space that provides a concealed receptacle (store) for a surprise incentive in the cup. The open section2 distinctly functions to be used as a conventional cup to serve the drink. The detachable partition wall includes a tab handle positioned towards the base of its main wall, that is used as a grip to slide it out from the wall holder and retrieve the surprise incentive from the enclosed sectionl in the cup. The cup is intended to provide a compartment, to retain a surprise incentive that is concealed and can be smoothly retrieved after consuming the served drink, thereby improvising the conventional use of a serving cup and keeping the user particularly children engaged.
Patent CA-3073484-A1 (CA)
Inventor: ANITUA ALDECOA EDUARDO
IPC: A61C8/00
Filed: 2018-08-27
Abstract: A dental prosthesis (1) with an angled inner bore (2) is proposed, formed by a first hole (7) and a second hole (26) connected by an angled connection area (29) formed with an angle between 0° and 180°.  An outer area (31) and side areas (32) of the angled connection area (29) form an elbow (40) devoid of protruding edges directed towards the interior of the inner bore (2). Said elbow (40) facilitates the insertion and extraction of a screw through the inner bore (2) during the assembly or disassembly of the dental prosthesis (1) on a dental implant. Some methods of manufacturing said dental prosthesis (1) are also proposed.
Patent CA-3073734-A1 (CA)
Inventor: HONG KEELUNG
IPC: A61K31/167
Filed: 2018-08-28
Abstract: Provided is an anesthetic composition for locally administrating an amide-type anesthetic into a subject in need thereof. The anesthetic composition has multilamellar vesicles with en trapped amide-type anesthetic prepared by hydrating a highly entrapped lipid structure comprising an amide-type anesthetic and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more feasible process for large-scale manufacture and for providing a high molar ratio of amide-type anesthetic to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.
Patent CA-3074489-A1 (CA)
Inventor: AL-YAMI ABDULLAH
IPC: C09K8/508
Filed: 2018-09-07
Abstract: A lost circulation material (LCM) is provided having an acidic nanosilica dispersion and a polyamine activator. The acidic nanosilica dispersion and the polyester activator may form a gelled solid after interaction over a contact period. Methods of lost circulation control using the LCM are also provided. A well treatment fluid is also provided having an acidic nanosilica dispersion and a polyamine activator. The acidic nanosilica dispersion and the polyamine activator may form a gelled solid after interaction over a period. Methods of reducing water production using the well treatment fluids are also provided.
Patent CA-3076670-A1 (CA)
Inventor: QIU BAO
IPC: H01M4/525
Filed: 2018-01-03
Abstract: L'invention concerne un matériau d'électrode positive en oxyde riche en lithium. Au moins un paramètre de pile unitaire (a, b, c) du matériau décroît à mesure que la température augmente à une température comprise entre 50 et 350 degrés. Après un traitement pendant 0,5 à 10 heures dans la condition comprise entre 150 et 350 °C, le degré d'organisation de la structure de matériau est accru, et le matériau a une capacité spécifique de décharge supérieure et une tension de décharge supérieure lorsqu'il est appliqué à une électrode positive d'une batterie lithium-ion.
Patent CA-3077482-A1 (CA)
Title: Removal of biological deposits
Inventor: SPEIGHT ROBERT
IPC: C11D3/386
Filed: 2018-06-25
Abstract: Provided herein is a method of at least partly removing a biological deposit, such as a dag, from the skin of an animal. The method includes administering to the biological deposit an effective amount of a composition containing a keratinase, and optionally one or both of a reducing agent and a surfactant. Also provided is a composition for use in the aforementioned method as well as a method of making same.
Patent CA-3078594-A1 (CA)
Title: Double-plate rotary barrel pump
Inventor: TRICARD JEAN
IPC: F04B1/32
Filed: 2018-10-08
Abstract: The present invention relates to a rotary barrel pump (6) comprising two plates: a movable plate (2) also driven by the drive shaft (5), and a plate (7) with variable inclination, wherein the two plates (2, 7) are connected to one another such that they can pivot.
Patent CA-3078649-A1 (CA)
Title: Device and method for capacitive measurement of a filling level of a filling medium
Inventor: SCHULTHEIS HOLGER
IPC: G01F23/26
Filed: 2018-10-08
Abstract: The invention relates to a device (1) for capacitively measuring a fill level of a filling medium (2) in a filling volume (3) that can be filled with a filling medium, comprising: a first measuring element (5), a second measuring element (6), the second measuring element (6) being designed in such a way that a potential gradient is formed between a first portion (6a) of the second measuring element (6) and a second portion (6b) of the second measuring element (6); a voltage-generating apparatus (7), which is associated with the second measuring element (6) and which is designed to generate a first voltage (U1) and a second voltage (U2), which is optionally different from the first voltage (U1), and to apply the same to the second measuring element (6); a control apparatus (8), which is associated with the voltage-generating apparatus (7) and which is designed to control the operation of the voltage-generating apparatus (7) in such a way that the first voltage (U1) and the second voltage (U2) are alternately applied to the first portion (6a) and the second portion (6b) of the second measuring element (6).
Patent CA-3078949-A1 (CA)
Title: Compositions containing difluoromethane, tetrafluoropropene, and carbon dioxide and uses thereof
Inventor: HUGHES JOSHUA
IPC: C09K5/04
Filed: 2018-10-03
Abstract: In accordance with the present invention refrigerant compositions are disclosed. The compositions comprise a refrigerant mixture consisting essentially of HFC-32, HFO-1234yf, and CO2. The compositions are useful in processes to produce cooling and heating, in methods for replacing refrigerant R-32, and in refrigeration, air conditioning or heat pump systems. These inventive compositions are match cooling performance for R-32 with GWP less than 400 or less than 300.
Patent CA-3079344-A1 (CA)
Title: Toolless quick connect rebar coupler
Inventor: CROSS BRANDON LEE
IPC: E04C5/16
Filed: 2020-04-24
Abstract: A rebar coupler having a casing with two opposite ends disposed along a central longitudinal axis. Each opposite end includes a frustum-shaped internal wall tapering along the axis from an inward to an outward position, as well as an assembly of a plurality of locking jaws, arrayed around the axis and engaging the internal wall, at least a portion of a spring, aligned with the axis and engaging the locking jaws, and a spacer, initially positioned within and engaging the locking jaws to separate the locking jaws and bias the assembly towards the inward position. The spacer is ejectable from the locking jaws through a center of the spring by insertion of a rebar end through the outward position and past the initial position of the spacer, whereupon the spring biases the locking jaws toward the outward position and into full engagement with the rebar end.
Patent CA-3079680-A1 (CA)
Inventor: JARNES WEBJORN
IPC: A47C1/124
Filed: 2018-10-22
Abstract: There is described a seat module for use in furniture for sitting, the seat module comprising a backrest (1) and a seat (2) and a coupling element (3), the backrest (1) being adapted to run along rear grooves (7) arranged in respective sides of the coupling element at its rear edge, a rear portion of the seat (2) is connected to the backrest (1) and a front portion of the seat (2) is adapted to run along front grooves (9) arranged in respective sides of the coupling element in its leading edge. The seat module further comprises a tilting mechanism (15-19) connecting the coupling element with a support member or base (4).
Patent CA-3081059-A1 (CA)
Title: Pump reflectors for cladding-pumped optical fiber systems
Inventor: BERNIER MARTIN
IPC: H01S3/0941
Filed: 2020-05-20
Abstract: ABSTRACT Pump reflectors for use in cladding-pumped fiber systems, such as laser or amplifier systems, are provided, the pump reflector includes an optical fiber segment having at least one core and at leastone cladding. A cladding Bragg grating is written by femtosecond inscription in the optical fiber segment, and extending across at least a portion of the cladding. The cladding Bragg grating having a reflectivity profile encompassing the spectral profile of the pump and a spatial profile encompassing the pump spatial distribution in the cladding. A method of manufacturing a pump reflector using femtosecond light pulses is also provided. Date Recue/Date Received 2020-05-20
Patent CA-3083239-A1 (CA)
Title: A bioactive 3d encapsulation culture system for cell expansion
Inventor: PAREKKADAN BIJU
IPC: C12N11/08
Filed: 2018-11-21
Abstract: Systems and methods for growing cells are provided. A capsule for growing or storing cells includes a shell defining an interior compartment and a substrate for cell attachment located within the compartment. The substrate comprises a polymer and one or more adhesion molecules. The substrate for cell attachment can be an inner surface of the shell and/or a hydrogel disposed within the interior compartment. The capsule can further include a cell, such as a stem cell, adhered to the substrate
Patent CA-3085062-A1 (CA)
Inventor: NIELSEN BRUNO PROVSTGAARD
IPC: A61K9/20
Filed: 2018-12-07
Abstract: L'invention concerne un comprimé de nicotine se désintégrant par voie orale pour le soulagement de manque de nicotine comprenant une formulation de poudre pressée, le comprimé étant conçu pour se désintégrer dans une période inférieure à 60 secondes lors de l'administration orale, la formulation de poudre comprenant une quantité de nicotine et un agent de régulation du pH.
Patent CA-3085450-A1 (CA)
Title: Fluorinated 4-(substituted amino)phenyl carbamate derivatives
Inventor: FURUYA TAKERU
IPC: C07D217/22
Filed: 2018-12-13
Abstract: The application relates to 4-(substituted amino)phenyl carbamate derivatives, or pharmaceutically acceptable salts or solvates thereof, as KCNQ2/3 potassium channel modulators, and methods of their uses.
Patent CA-3086105-A1 (CA)
Inventor: DEODHAR MANDAR
IPC: C07C235/46
Filed: 2013-04-05
Abstract: 86780030 Abstract The present invention is related to the preparation and pharmaceutical use of substituted 3-haloallylamine derivatives as SSAON AP-1 inhibitors having the structure of Formula (I):L R4 R3 X R2 R5 R1 Formula 1 The invention also relates to methods of using compounds of Formula (I), or phamiaceutically acceptable salt or derivatives thereof, for the treatment of a variety of indications, e.g., inflammatory diseases, ocular diseases, fibrotic diseases, diabetes-induced diseases and cancer. Date Recue/Date Received 2020-07-03
Patent CA-3087180-A1 (CA)
Inventor: ABBOTT JAMES R
IPC: F16H1/26
Filed: 2020-07-17
Abstract: Power takeoff devices (PTOs) are useful for mounting on transmissions and for performing, directly or indirectly, useful work via the mechanical energy generated by the PTO's rotatable output shaft. Systems and methods for reducing PTO gear rattle include a moveable input gear engaging and intermediate to an output gear and a transmission gear.  The input gear is carried on an input gear carrier moveable such that the input gear centerline moves along a plane substantially perpendicular to a plane running between the centerlines of the output and transmission gears. The input gear travel is limited by the output and transmission gears such that the input gear is biased to engage at least one of the output gear and the transmission gear, thereby reducing or eliminating gear rattle from overly loose engagement between meshing teeth on the input gear and the transmission gear or output gear.
Patent CA-3087625-A1 (CA)
Inventor: BAREWAL REVA
IPC: A21D10/00
Filed: 2019-01-02
Abstract: Des exemples de la présente invention concernent un produit alimentaire et un procédé de production d'un produit alimentaire. Un exemple de l'invention concerne un produit alimentaire comprenant un réseau de substrat contenant de l'aquafaba moussée, un constituant de renforcement conçu pour fournir une résistance mécanique au réseau de substrat contenant de l'aquafaba moussée, un constituant d'augmentation de la viscosité à base de polysaccharide, et un amidon.
Patent CA-3088318-A1 (CA)
Inventor: RAJEWSKI CAL ROBERT
IPC: F23G7/08
Filed: 2020-07-29
Abstract: There is a flare stack diffuser tip for use with a flare stack having a waste gas conduit. The flare stack diffuser tip has one or more concentric diffuser rings. One or more radial transfer spokes connect to the waste gas conduit of the flare stack to receive waste gas. The one or more radial transfer spokes is in fluid connection with the one or more concentric diffuser rings.
Patent CA-3088786-A1 (CA)
Inventor: THERIAULT STEVEN
IPC: A01N63/40
Filed: 2019-01-21
Abstract: L'invention concerne une méthode de modification de bactériophages consistant à : identifier un bactériophage avec un seul gène de fixation ; isoler ledit bactériophage ; éliminer ledit gène de fixation du génome dudit bactériophage ; et insérer un gène de fixation non naturel dans le génome dudit bactériophage, ledit gène de fixation non naturel étant spécifique à une fixation à une bactérie sélectionnée. L'invention concerne également un bactériophage mutant comprenant une séquence d'acide nucléique hétérologue codant pour un premier gène de fixation spécifique, le premier gène de fixation spécifique étant différent d'un gène de fixation inactivé et étant spécifique à une bactérie sélectionnée. Selon un autre mode de réalisation, l'invention concerne une méthode d'élimination d'un contaminant microbien, la méthode consistant à : obtenir une ou plusieurs enzymes lytiques produites par un bactériophage mutant ; appliquer la ou les enzymes lytiques à un contaminant bactérien, sans infection préalable du contaminant bactérien avec un bactériophage, de façon à éliminer le contaminant bactérien.
Patent CA-3089587-A1 (CA)
Title: Nucleases specifiques de cible specifiquement modifiees
Inventor: DEKELVER RUSSELL
IPC: C12N9/22
Filed: 2019-02-08
Abstract: L'invention concerne des nucléases spécifiquement modifiées comprenant des mutations dans le domaine de clivage (par exemple, FokI ou un homologue de celui-ci) et/ou un domaine de liaison à l'ADN (protéine en doigt de zinc, TALE, ARN guide unique) de telle sorte qu'une spécificité sur la cible se trouve augmentée.