baber/WOPTO huggingface dataset:
Patent NZ-333857-A (NZ)
Title: Illudin analogs and their use as antitumor agents
Inventor: MCMORRIS TEVOR C
IPC: C07C49/737
Filed: 1997-07-14
Abstract: Illudin analogs of general formula (I) where: R1 is (CH2)n-X-Y or H; n is 0 to 4; X is O or S or N or absent; and Y is -CH2OC(O)(C1-C4)alkyl, (C1-C8)alkyl optionally substituted with 2 OH or 1-2 halo, a monosaccharide, -CH2C(O)-O-C(O)CH2SH, -(CH2)2-O-(CH2)2W where W is halo, -(C1-C8)alkyl-O-(C1-C8)alkyl, (C6-C10)aryl, (C6-C10)aryl(C1-C4)alkyl, -C(O)O(C6-C10)aryl wherein the aryl group is optionally substituted with 1-2 OH, halo, (C1-C4)alkyl, O(C1-C4)alkyl, -CO2CO2(C1-C4)alkyl, -CH2CO2H, Si((C1-C4)alkyl)3 or an amino acid residue, R3 is (C1-C4)alkyl or H; R4 is H, SCH2CO2(C1-C4)alkyl, O-(C5-C12)aryl or -S-(C5-C12)aryl; R5 is H, OH or absent; R6 is (C1-C4)alkyl R7 is OH or OSi((C1-C4)alkyl)3; or R6 and R7 together are ethylenedioxy; R8 is optionally substituted (C1-C4)alkyl; and the bonds represented by ----- are individually present or absent. Also disclosed are dimers comprising analogs for formula (I) and the use of compounds of formula (I) in inhibiting tumor cell growth
Patent NZ-335005-A (NZ)
Title: Method for stabilizing cytokine using a compound arabic acid or the like
Inventor: OKANO FUMIYOSHI
IPC: A61K38/21
Filed: 1998-07-31
Abstract: A method for stabilizing cytokine comprising mixing the cytokine with aqueous solutions of compounds having a fundamental structure of arabic acid. It is preferable to use acacia as the compounds having a fundamental structure of arabic acid. This method is also particularly efficacious in stabilizing interferons.
Patent NZ-501795-A (NZ)
Title: Liposome vectors for active principles
Inventor: SALLES JEAN-PIERRE
IPC: A61K9/133
Filed: 1998-06-11
Abstract: Liposome vectors, in powder form, for active principles, and more particularly active principles sensitive to digestive and/or plasmatic degradation, such as proteins, and their application in medicine are described. The liposome vectors comprise (i) a pulverulent composition consisting of unilamellar liposomes comprising an external lipid phase consisting of class 4 lipids (phospholipids), optionally associated with class 2 substances, class 3 substances and/or class 5 substances and an internal aqueous nucleus consisting of a mixture M of at least two different non-polymerisable gelling agents (G1 and G2) whereof the gel-sol phase transition is not less than 37 DEG C, G1 being selected among gelatines and carrageenans and G2 being selected among carrageenans with properties different from the carrageenans selected for G1, and celluloses, which liposomes have a diameter ranging between 20 nm and 1 um; said composition having the form of particulate units with an average particle diameter between 10 um and 1000 um, formed by one or several of said liposomes, surrounded by a matrix selected from the group consisting of a dehydrated temperature reversible aqueous gel, dextrins or a mixture thereof, such that they contain, on an average, 1016 to 1018 liposomes per gram of powder; and at least an active principle contained, as the case may be, either in the gelled internal nucleus or in the external lipid phase.
Patent NZ-503682-A (NZ)
Title: Information management system with data storage and retrieval, and control to input data set to data retrieval tool
Inventor: CASSON GARRY
IPC: G06F17/30
Filed: 1998-10-15
Abstract: An information management system is provided including a database and one or more data retrieval tools, a data retrieval tool being arranged to retrieve information according to registered interests of users of the system and to store data in the database relating to the information retrieved. User interests may be stored in the database as user profiles comprising one or more keywords. In addition, projects may be defined, each project having a profile stored within the system. A user interface enables a user to enter user and project profile or other information, and a data input tool is provided to generate from the user input one or more data sets for storage as profiles in the database. Control means are provided to take user input, submit it to the data input tool and to supply data sets generated and stored thereby to the data retrieval tool for use in searching and locating relevant information. A user may also manually select, from output by a data retrieval tool, information for persistent storage in relation to the user's profile or in relation to one or more projects to which the user has appropriate access. The control means may be arranged to control access by users to view or modify projects and to share associated information.
Patent NZ-505673-A (NZ)
Title: Medication delivery apparatus for automated sequential or concurrent infusion of pharmacological agents having chambers configured to control the volume and the rate at which each pharmacological agent is administered
Inventor: LIEBERMAN MARC S
IPC: A61M5/142
Filed: 1999-01-14
Abstract: A fluid delivery apparatus to provide an automated system based on an integral fluid bag for administering a variety of intravenous drug regimens and reducing the vagaries of existing manual systems.  The fluid has multiple chambers configured to implement a prescribed intravenous medical therapy. Each chamber's geometry (size, shape), sequence and position, alone and in combination with the other chambers, matches the prescribed intravenous therapy or drug regimen. The bag's configuration assures that the intravenous therapy is administered in accordance with the prescribed drug regimen, thus automating the previous manual method. A choice of fluid bag configurations may be stocked so that a prescription for well known and widely accepted drug regimens may be filled by merely selecting a bag with the appropriate chamber configuration and filling it with the prescribed medications.
Patent NZ-506243-A (NZ)
Title: Pushchair having a footrest which is mounted in rotary bearings and lockable in at least two positions to provide height adjustment
Inventor: MAXISCH PETER
IPC: B62B9/12
Filed: 2000-08-09
Abstract: Footrest 16 is mounted on rotary bearings via cylindrical discs 20 in cylindrical recesses 19. Footrest 16 is adjustable to at least two positions to provide height adjustments. Typically the footrest can be rotated half a turn and locked.
Patent NZ-508281-A (NZ)
Title: Interactive television program guide system for determining user values for demographic categories
Inventor: KNEE ROBERT A
IPC: H04N21/45
Filed: 1999-05-13
Abstract: An interactive television program guide system for determining user input values for demographic categories is provided. The system includes user television equipment (44) having a receiver for receiving program guide information for the interactive television program guide, a user input receiver (62) for receiving user input from user interface, such as a remote control (54), a microprocessor which utilizes the user input received to determine user values for demographic categories, and memory for storing the user values determined. In one illustrative use of the system for targeting advertisements to a user of the interactive television program guide, the receiver also receives advertisements, where the advertisements have preselected values for specified demographic categories. The user television equipment, preferably using microprocessor, compares the preselected values for the specified demographic categories associated with the advertisements with values of corresponding demographic categories stored in memory to determine which advertisements should be displayed. Those advertisements determined to be displayable based upon the comparison are then displayed.
Patent NZ-509372-A (NZ)
Title: Substituted quinolin-2-one derivatives, pharmaceuticals thereof and their use for treating abnormal cell growth (e.g. cancer)
Inventor: LYSSIKATOS JOSEPH PETER
IPC: C07D215/22
Filed: 1999-08-06
Abstract: The present invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are as defined herein. The above compounds of formula (1) are useful in the treatment of hyperproliferative disorders, such as cancer, in mammals. The invention also relates to pharmaceutical compositions containing the compounds of formula (1) and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering the compounds of formula (1) to a mammal requiring such treatment.
Patent NZ-517516-A (NZ)
Title: Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl- phenoxy derivatives useful as D4 antagonists
Inventor: SHUTSKE GREGORY M
IPC: A61K31/4365
Filed: 2000-09-13
Abstract: The compound of Formula I, where: T, T' and T" are respectively C, O and N producing benzisoxazolyl; C, S and C producing benzthienyl; or N, O and N producing pyridoisoxazolyl; X is H or halo; A is -CH2CH2-or -CH2C(R1)(R2)CH2-; R3 is (CH2)nQ, CH2CH(OH)Q, CH(CH3)Q, 1,2,3,4- tetrahydronaphthyl, indanyl optionally substituted with hydroxy, or adamantyl; R4 is H or C1-6 alkyl; or R3 and R4, together with the nitrogen atom to which R3 and R4 are attached, form 4,5,6,7- tetrahydrothieno[3,2,c]pyridinyl, 1,4-dioxa-8-azo- spiro[4.5]decanyl, piperazinyl, morpholinyl, piperidinyl, pyrrolidinyl, azepanyl, azocanyl, 1,2,3,4- tetrahydroisoquinolinyl, 1,2,3,4-tetrahydro-1H-b-yl, or 8- aza-bicyclo[3.2.1.]octanyl, each of which may optionally be substituted. Also described is a composition comprising a compound of Formula I as defined above and an inert carrier.
Patent NZ-519377-A (NZ)
Title: (3-Amino-2-fluoropropyl)(methyl)phosphinic acids useful for treating gastro-oesphageal reflux disease
Inventor: GUZZO PETER
IPC: A61K9/30
Filed: 2000-12-04
Abstract: Compounds of formula (I) their pharmaceutically acceptable salts, solvates and stereoisomers, as well as a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and the use of said active compounds in therapy are disclosed, wherein: R1 represents hydrogen or lower alkyl; R2 represents a fluoro group; R3 represents hydrogen; R4 represents hydrogen; R5 represents methyl, fluoromethyl, difluoromethyl or trifluoromethyl. These compounds of formula (I) have affinity to one or more GABAB receptors and are useful for the treatment of diseases such as of gastro-oesophageal reflux disease, regurgitation in infants, GORD-related or non-GORD related asthma, belching, coughing, pain, cocaine addition, hiccups, IBS, dyspepsia, emesis, nociception or the inhibition of transient lower oesophageal sphincter relaxations
Patent NZ-522262-A (NZ)
Title: Method and software for identifying and creating connections and accountability in a business organization
Inventor: CARDWELL JAMES
IPC: G06Q10/00
Filed: 2001-03-29
Abstract: A computer-network-aided method for interconnecting multiple sections of an organization, the organization having multiple layers comprises: creating an electronic data table, the data table containing at least one objective of the organization, at least one goal of the organization, and priority levels for the at least one objective; providing means for analyzing the at least one objective via a computer network; providing means for organizing the at least one objective via the computer network; creating at least one team project based on the at least one objective via the computer network; connecting the at least one team project to the at least one objective, via the computer network, such that when the at least one objective is altered, the at least one team project is automatically updated to reflect the alteration to the at least one objective; assigning at least one task based on the at least one team project; connecting the at least one task to the at least one team project, via the computer network, such that when the at least one team project is altered, the at least one task is automatically updated to reflect the alteration to the at least one team project; assigning priority levels to the at least one objective, the at least one team project, and the at least one task; allowing an associated employee, with access to the data table, to access and edit, via the intranet, the at least one team project; and, providing means for comparing the at least one objective, the at least one team project, and the at least one task.
Patent NZ-522281-A (NZ)
Title: Fully vented wide rim nursing bottle
Inventor: BROWN CRAIG E
IPC: A61J11/02
Filed: 2001-05-04
Abstract: A nursing bottle (1) is formed of a large volume container, incorporating a vent tube (3) that extends inwardly of the container, having a vent port (4) arranged approximately at the volumetric midpoint of the container, so as to allow for venting of pressure, whether of excessive or vacuum, to the atmosphere. The bottle may be formed of a spherical shape (1), or to other configurations such as hemispherical shape or cylindrical shape, (not shown) that provide for the internal volumetric capacity.
Patent NZ-522372-A (NZ)
Title: Mutation in the beta 2 nicotinic acetylcholine receptor subunit associated with nocturnal frontal lobe epilepsy
Inventor: PHILLIPS HILARY ANNE
IPC: A61K48/00
Filed: 2001-05-11
Abstract: An isolated DNA molecule encoding a mutant beta-subunit of a mammalian nicotinic acetylcholine receptor ( nAchR ) is described wherein a mutation event selected from a point mutation, deletion, insertion and rearrangements has occurred in the nucleotides encoding the M2 domain of the beta-subunit of the receptor. The mutation event disrupts the functioning of an assembled mammalian nicotinic acetylcholine receptor comprising the beta subunit so as to produce an epilepsy phenotype. Preferably the mutation is a G to A nucleotide transition at base 1025 to produce a V287M mutation in the beta-subunit of the encoded protein. Polypeptide, antibodies, methods and uses for treating and diagnosing epilepsy are described.
Patent NZ-523956-A (NZ)
Title: A process for the production of paper
Inventor: FROLICH STEN
IPC: D21H21/16
Filed: 2001-08-02
Abstract: The invention relates to a process for the production of paper from an aqueous suspension containing cellulosic fibres, and optional fillers, which comprises separately adding to the suspension a cationic organic polymer having one or more aromatic groups and an anionic polymer having one or more aromatic groups, the anionic polymer being selected from step-growth polymers, polysaccharides and naturally occurring aromatic polymers and modifications thereof, forming and draining the suspension on a wire, with the proviso that if the anionic polymer is a step- growth polymer it is not an anionic melamine-sulphonic acid condensation polymer. The invention further relates to a process for the production of paper from an aqueous suspension containing cellulosic fibres, and optional fillers, which comprises separately adding to the suspension a cationic organic polymer having one or more aromatic groups and an anionic polymer having one or more aromatic groups, forming and draining the suspension on a wire, with the proviso that the anionic polymer is not an anionic polystyrene sulphonate or anionic melamine- sulphonic acid condensation polymer.
Patent NZ-528168-A (NZ)
Title: Method to prepare microparticles metoprolol that contain
Inventor: DJURLE ALF
IPC: A61K9/20
Filed: 2002-03-06
Abstract: A method of preparing a homogeneous microparticle of metoprolol the method comprising: providing a granulation liquid medium comprising a solid content of metoprolol; spraying the granulation liquid medium into a fluidized bed; and selecting out a microparticle that has a size distribution of less than 250mu m, thereby obtaining a dry, homogeneous microparticle having at least 80% by weight of metoprolol.
Patent NZ-528515-A (NZ)
Title: New process for the preparation of oxabispidines
Inventor: CHEEMA LAL
IPC: C07D498/08
Filed: 2002-04-12
Abstract: A method of preparation of oxabispidine compounds that bear an N-2- (alkoxycarbonylamino) ethyl substituent is described. In particular, a process for the preparation of a compound of formula I is disclosed wherein R1 represents H, an amino protective group or a structural fragment of formula Ia. The process comprises reaction of a compound of formula II with either a compound of formula III or acrylaminde, followed by reaction of the resulting intermediate of formula IV with an alcohol of formla R2-OH and an agent that promotes, or agents that in combination promote, rearrangement and oxidation of the compound of formula IV to an intermediate isocyanate, which may then react with the alcohol of formula R2-OH.
Patent NZ-532395-A (NZ)
Title: Supercritical fluids processing: preparation of protein microparticles and their stabilisation
Inventor: GENTILE MARCO
IPC: C12N9/96
Filed: 2002-10-21
Abstract: A process for the co-precipitation of a protein or polypeptide with a stabilizer by a gas anti solvent process, which comprises introducing into a particle formation vessel a supercritical fluid pure or mixed with a modifier, and a solution comprising said protein or polypeptide and said stabilizer dissolved in a solvent. The solvent is extracted from the solution by the supercritical fluid and co-precipitation of the substance and stabilizer occurs, wherein said stabilizer is a sugar.
Patent NZ-532896-A (NZ)
Title: Stable liquid pharmaceutical formulation of IGG antibodies including daclizumab and fontolizumab
Inventor: KAISHEVA ELIZABET A
IPC: A61K47/26
Filed: 2002-11-08
Abstract: Disclosed is a stable liquid pharmaceutical formulation comprising: 20-60 mM succinate buffer having pH of pH 5.5 to pH 6.5, 0.02%-0.04% polysorbate, 75-150 mM sodium chloride, and an antibody which is Daclizumab, wherein said antibody has a concentration of 50 mg/ml or more. This liquid formulation is suitable for subcutaneous injection. This liquid formulation may be stable at refrigerated temperature (2-8 DEG C) for at least 1 year. The description also exemplifies liquid pharmaceutical formulation having other antibodies such as a humanized anti-IL-2 receptor monoclonal antibody; HAIL-12, a humanized anti-IL-12 monoclonal antibody; HuEP5C7, a humanized anti-L selectin monoclonal antibody; and Flintozumab, a humanized anti-gamma interferon monoclonal antibody.
Patent NZ-533550-A (NZ)
Title: Modified polypeptide
Inventor: ROSS RICHARD
IPC: C07K19/00
Filed: 2002-12-06
Abstract: A chimeric polypeptide comprising: (i) at least one modified growth hormone receptor binding domain of growth hormone wherein said modification is the addition, deletion or substitution of at least one amino acid residue; and (ii) a growth hormone binding domain of growth hormone receptor.
Patent NZ-535978-A (NZ)
Title: Novel spiroazabicyclic heterocyclic amines useful as nicotinic acetylcholine receptor agonists
Inventor: CHANG HUI-FANG
IPC: A61P43/00
Filed: 2003-04-15
Abstract: Disclosed is a compound having the formula I and pharmaceutically acceptable salts thereof, wherein: Ar is selected from a 2-, or 3-linked thienyl or benzofused thienyl substituted with 0, 1, 2 or 3 substituents independently selected at each occurrence from C1-4 alkyl, C1-4 alkoxy, C1-4 halogenated alkyl, C1-4 oxygenated alkyl, C2-4 alkenyl, C2-4 alkynyl, halogen, -CO2R1, -C(O)R1, -CN, -NO2, -NR1R2; R1 and R2 are independently selected at each occurrence from hydrogen or C1-4 alkyl; R is a substituent selected from hydrogen, C1-4 alkyl, C1-4 halogenated alkyl, C1-4 oxygenated alkyl, or halogen. The compounds may be used to manufacture medicaments for the treatment or prophylaxis of human diseases or conditions in which activation of the a7 nicotinic receptor is beneficial.
Patent NZ-537781-A (NZ)
Title: Taci antibodies and uses thereof
Inventor: CHUNTHARAPAI ANAN
IPC: C12P21/08
Filed: 2003-07-25
Abstract: Provided is an agonist antibody that specifically binds to a TACI receptor, wherein the antibody inhibits B-cell proliferation and activates NF-kB. Further provided are specific antibodies deposited with ATCC and hybridoma cell lines producing the antibody. Also provided is the use of the antibody for the preparation of a medicament for treatment of immune-related disease or cancer.
Patent NZ-538045-A (NZ)
Title: Method of transfusion with an acellular red blood cell substitute
Inventor: DE WOSKIN RICHARD E
IPC: A61K31/00
Filed: 1997-03-27
Abstract: A aqueous solution of pyridoxylated, polymerized haemoglobin is used in the manufacture of a composition for preserving an organ for transplant, in the manufacture of a transfusion for solution for treating diseases or conditions requiring a resuscitative fluid, intravascular volume expander or exchange transfusion or in the manufacture of an acellular red blood cell substitute for treating trauma, myocardial infarction, stroke, acute anaemia, hypoxemia, hypoxia or end stage hypoxia. The haemoglobin comprises about 16% of haemoglobin polymer with a molecular weight of about 128 kD, about 26% of haemoglobin polymer with a molecular weight of about 192 kD, and about 58% of haemoglobin polymer with a molecular weight of about 256 kD. (62) Divided Out of 510226
Patent NZ-543355-A (NZ)
Title: Crystalline form of the Beta 2 adrenergic receptor agonist N-{2-[4-((R)-2-hydroxy-2-phenylethylamino)phenyl]ethyl}-(R)-2-hydroxy-2-(3-formamido-4-hydroxyphenyl)ethylamine monohydrochloride
Inventor: STERGIADES IOANNA
IPC: A61K31/16
Filed: 2004-05-26
Abstract: Disclosed is the crystalline monohydrochloride salt of N-{2-[4-((R)-2-hydroxy-2-phenylethylamino)phenyl]ethyl}-(R)-2-hydroxy-2-(3-formamido-4-hydroxyphenyl)ethylamine (Formula I). Further disclosed are pharmaceutical compositions which comprise a therapeutically effective amount of the above compound. A process for preparing the monohydrochloride salt of the compound of formula I is also disclosed, as is the use of the monohydrochloride salt of formula I in the manufacture of a medicament for treating a disease or condition associated with b2 adrenergic receptor activity in a mammal. The use of the medicament for treating pulmonary diseases such as asthma or chronic obstructive pulmonary disease is further disclosed.
Patent NZ-546940-A (NZ)
Title: 4-Biarylyl-1-phenylazetidin-2-ones
Inventor: TALLEY JOHN J
IPC: A61K31/7052
Filed: 2004-11-10
Abstract: Disclosed are compounds of the following formula, wherein the substituents are as defined in the specification. The compounds are useful for the treatment of hypercholesterolemia and cholesterol-associated benign and malignant tumors.
Patent NZ-553695-A (NZ)
Title: Isolation of stem/progenitor cells from amniotic membrane of umbilical cord
Inventor: PHAN TOAN-THANG
IPC: C12N5/074
Filed: 2005-06-03
Abstract: Disclosed is a method for isolating stem/progenitor cells from the amniotic membrane of umbilical cord, the method comprising: a) separating the amniotic membrane from the other components of the umbilical cord in vitra; b) culturing the amniotic membrane tissue obtained in step (a) under conditions allowing cell proliferation; and c) isolating the stem/progenitor cells.
Patent NZ-553846-A (NZ)
Title: Fast-curing modified siloxane compositions
Inventor: GOMMANS LOUIE HERMAN
IPC: C08K3/34
Filed: 2005-09-13
Abstract: Disclosed is a fast-curing modified siloxane composition comprising; an alkoxy- or silanol-functional silicone intermediate; at least one amine reactive ingredient selected from the group consisting of acetoacetate-functional ingredients, acrylate-functional ingredients, and mixtures thereof; an epoxy-functional ingredient; a curing agent selected from the group consisting of amines, aminosilanes, ketimines, aldimines and mixtures thereof; and water.