baber/WOPTO huggingface dataset:
Patent EA-015126-B1 (EA)
Title: Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors
Inventor: VANOTTI ERMES
IPC: C07D405/04
Filed: 2007-03-19
Abstract: The present invention provides compounds of the formula (I)or the pharmaceutically acceptable salts thereof, wherein G, W, R, R, R, Rand Rare as defined in the specification. Further objects of the invention are processes and intermediates for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
Patent EA-017551-B1 (EA)
Title: Shoe heel protector
Inventor: RODIK MARIA ANATOLIEVNA
IPC: A43B23/30
Filed: 2010-04-23
Abstract: The present invention relates to light industry, in particular to shoe heel protector devices from wear, scuffing and dirtiness including for shoe protection while driving a motor vehicle. The device for shoe heel protector is made as a monolithic open mirror-symmetrical elongated convex-concave body from a polymeric elastic material comprising side walls and a rear part connecting the side walls, wherein the body has a transverse section variable along its height, the shape and sizes of which conventionally divide the body to upper, medium and bottom zones according to its height, wherein the rear part, side walls and the upper, medium and bottom zones are joint together smoothly and monolithic. The technical inventive result is aimed at a design simplification, improving manufacturability and labor saving for its production and also in a long-time preservation of reliable operation features due to the used material and design values while providing convenience and easiness of use, reliable holding the device on a user's shoe in case of resting the device on the shoe heel.
Patent EA-020980-B1 (EA)
Title: Effluent consumption modular meter
Inventor: MOULARD JEAN-MICHEL
IPC: G01R35/04
Filed: 2008-12-11
Abstract: The invention relates to an effluent consumption modular meter. It comprises a base module (MS) providing the connection between effluent distribution mains pipes and a subscriber supply, equipped with a metering connection interface (ICC) and a metering module (MC) equipped with an interface for connecting to the base module (MC), via the metering connection interface (ICC). Electrical components of a permanent nature (FNI) are installed in the base module and electronic components of a changeable nature (FI) are installed in the metering module (MC). Application to effluent meters, particularly electricity meters.
Patent EA-017466-B1 (EA)
Title: Anti-trap device for door frame
Inventor: DEVEZE ALAIN
IPC: E05D7/10
Filed: 2009-04-17
Abstract: In this device, the frame has, facing a rounded edge (6) of the leaf B, an inclined surface (21), the distance of which from the frame A increases from the inside to the outside and which is connected to the internal surface of a covering strip (25), this strip being positioned parallel to the wall of the frame and at least in front of the rounded edge (6) of the leaf B in order to prevent any access into the external gap between leaf B and frame A, while each of the hinge plates comprises, firstly, a male element (2) fitting into a housing (7) in the leaf, so as to be aligned therewith, and, secondly, a female element (3) composed of: a cylindrical hinge body (3a) fitting into the male element (2) so as to come into alignment with the rounded part (6); and a fastening base (3b) fitting into a housing (20) recessed into the inclined surface (21) of the frame so as to come into alignment with this surface.
Patent EA-022443-B1 (EA)
Title: End or back panelling for metal shelving units designed to display merchandise
Inventor: PASSANTI ANDREA
IPC: A47F5/10
Filed: 2009-09-14
Abstract: End or back panelling for metal shelving units designed to display merchandise, characterized in that it has back panels (3) which are in the form of flat sheets and have reinforcing folds (103, 203) which increase their resistance to transverse bending stresses, even though made of sheet metal with a limited thickness.; These panels (3) have dimensions comprising a width (L3) suitably smaller than the distance (D) which is present between the inner sides of the uprights (1, 1 ') of the shelving unit and are provided laterally with engaging lugs (4, 5), the extension (L4) of which, added to said useful width (L3) of the panel (3), is equal to or slightly less than said inner distance (D) between the uprights, all of which in such a way that it is possible firstly to insert the engaging lugs (4, 5) of one vertical side of a panel (3) into the eyelets (2) of a corresponding upright (1), keeping the back panel (3) initially inclined, so as not to interfere with the other upright (1 '), following which the same panel (3) is inserted perpendicularly between the two uprights of the shelving unit and is displaced horizontally so as to insert also its other lateral engaging lugs (4, 5) into the eyelets (2); of the other upright and, once the panel is symmetrically arranged between the uprights, it is displaced downwards so that slits (5) formed in the bottom side of the said lateral lugs (4) fit onto the bottom sides of the eyelets (2) of the uprights, locking the back panels (3) in position.
Patent EA-035795-B1 (EA)
Title: HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AS JANUS KINASE INHIBITORS
Inventor: RODGERS JAMES D
IPC: A61P17/00
Filed: 2006-12-12
Abstract: The invention relates to a medicament for treating polycythemia vera (PV) in a patient, wherein said disease is associated with JAK activity, comprising a therapeutically effective amount of a compound which is 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile or a pharmaceutically acceptable salt thereof. The invention also relates to the use of a compound which is 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile or a pharmaceutically acceptable salt thereof for treating polycythemia vera (PV) in a patient, wherein said disease is associated with JAK activity. Said compound or salt is (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile or a pharmaceutically acceptable salt thereof, or (3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile or a pharmaceutically acceptable salt thereof.
Patent EA-025466-B1 (EA)
Title: Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use thereof
Inventor: SU WEI-GUO
IPC: C07D487/04
Filed: 2010-12-30
Abstract: Provided are certain triazolopyridines and triazolopyrazines of formula 1where X, Y, R, R, R, Rand Rhave any of the meanings described herein; a process for preparing them; pharmaceutical compositions thereof; and use thereof as c-Met inhibitors for treating cell proliferative disorders.
Patent EA-022462-B1 (EA)
Title: Calcium salts of compound as anti-inflammatory, immunomodulatory and anti-proliferatory agents
Inventor: AMMENDOLA ALDO
IPC: C07D333/58
Filed: 2011-07-01
Abstract: The present invention relates to a calcium salt of a compound of the general formula (I)wherein X is selected from the group consisting of CH, S, or O; D is O or S; Ris hydrogen; E is a phenylene group optionally substituted with one or more groups independently selected from halogen, nitro, C-Calkyl or C-Calkoxy; Y is a phenyl, pyridine or benzothiophene group optionally substituted with one or more groups independently selected from halogen, C-Calkyl, C-Calkoxy, halogen-C-Calkoxy, halogen-C-Calkyl or CN; n is 0 or 1, and q is 0 or 1; with the proviso that compounds wherein X is CH, q is 0, Y is unsubstituted phenyl and E is unsubstituted phenylene are excluded; or a hydrate thereof; to a pharmaceutical composition containing them, having inhibitory activity of dihydroorotate dehydrogenase (DHODH), to their use and also to a process for their manufacture.
Patent EA-024124-B1 (EA)
Title: Biocide tablet composition, biocide tablet and process for preparing same
Inventor: DAVE PARTHIV RIPUDAMAN
IPC: A01N59/14
Filed: 2011-08-12
Abstract: The present invention relates to a composition for preparing a biocide tablet comprising one or more halogenated 5,5-dialkylhydantoins, a chlorine biocide compound selected from trichloroisocyanuric acid (TCCA), sodium dichloroisocyanurate (NaDCC) and mixtures thereof, and 0.1-1.0% water soluble boron containing compound, wherein the ratio between the halogenated 5,5-dialkylhydantoin compound and chlorine biocide compound is in the range 85:15 to 65:35 and the average particle size of the halogenated 5,5-dialkylhydantoin compound and chlorine biocide compound is in the range 400 to 1200 microns. The invention also provides a biocide tablet with the weight 2-8 g, prepared by compressing the proposed composition using a force adjusted between 2 and 7 tonnes. The proposed biocide tablet can be used in gravity fed water purification devices and for purifying water for drinking purposes.
Patent EA-021724-B1 (EA)
Title: 4-SUBSTITUTED-3-PHENYLSULFANYLMETHYLBICYCLO[3.1.0]HEXANE COMPOUNDS AS mGluR 2/3 ANTAGONISTS
Inventor: SMITH STEPHON CORNELL
IPC: C07C323/58
Filed: 2011-11-15
Abstract: A mGlu2/3 receptor antagonist of the formulaits uses, and methods for its preparation are described.
Patent EA-027924-B1 (EA)
Title: Pre-formulation comprising somatostatin receptor agonist, method for preparation thereof, method of treatment by administering the same and pre-filled administration device containing the same
Inventor: TIBERG FREDRIK
IPC: A23L33/15
Filed: 2012-11-28
Abstract: The present invention relates to a pre-formulation comprising a low viscosity non-liquid crystalline mixture of: (a) 25-55 wt.% of at least one diacyl glycerol and/or at least one tocopherol; (b) 25-55 wt.% of at least one phospholipid component comprising phospholipids having (1) polar head groups comprising more than 50% phosphatidyl ethanolamine, and (2) two acyl chains each independently having 16 to 20 carbons wherein at least one acyl chain has at least one unsaturation in the carbon chain, and there are no more than four unsaturations over two carbon chains; (c) 5-25 wt.% of at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein 0.1-10 wt.% of at least one peptide active agent comprising at least one somatostatin receptor agonist is dissolved or dispersed in said low viscosity mixture; wherein said pre-formulation has a viscosity of 1 to 1000 mPa∙s at 20°C; and wherein said pre-formulation forms at least one non-lamellar liquid crystalline phase structure upon contact with an aqueous fluid. The present invention further relates to a method for the preparation of the claimed pre-formulation, to a method of treatment using the claimed formulation, as well as to a pre-filled administration device containing the same.
Patent EA-027802-B1 (EA)
Title: Grate carriage for receiving bulk material
Inventor: SCHULAKOW-KLASS ANDREJ
IPC: F27D5/00
Filed: 2013-04-19
Abstract: A grate carriage for receiving bulk material, in particular in a traveling grate of a pellet firing or sintering machine, includes a plurality of grate bars (3) arranged parallel to each other, wherein the grate bars (3) are movably held in lateral receptacles of the grate carriage and between the grate bars (3) a gap (11) each is provided. To avoid the jamming of pellets or material pieces in the gaps formed between the grate bars and thereby inhibit an increase in size thereof, a force application means is provided, which elastically presses the grate bars (3) arranged in parallel against each other.
Patent EA-030388-B1 (EA)
Title: Porous dental implant
Inventor: DOSTA ANATOLI DMITRIEVICH
IPC: A61C8/00
Filed: 2013-05-07
Abstract: The porous three-dimensional structure of the implant of increased strength is made as a three-dimensional body, contains open through pores and one-side open pores which are distributed evenly on the internal surface of open pores and connected to the internal surface, with sizes of pores randomly distributed in the range of 150-300 μm, and is equipped with the reinforcing element made from titanium or titanium alloy. The reinforcing element is made as a mesh with the protrusions evenly distributed on the outer surface of the mesh, and is located on the surface of the three-dimensional body.
Patent EA-030420-B1 (EA)
Title: Process for making a conditioning gel phase and conditioning hair composition comprising said gel phase
Inventor: CASUGBO CHRISTIA
IPC: A61Q5/12
Filed: 2013-07-24
Abstract: Provided is a process for making a conditioning gel phase comprising forming a comelt in a first vessel (A) comprising fatty alcohol having from 8 to 22 carbons, cationic surfactant component comprising from 0-70 wt.% from the weight of said cationic surfactant component, cationic surfactants having the formula NRRRR, wherein R, R, Rand Rare independently (C-C) alkyl or benzyl, and 0-15 wt.% water from the weight of said comelt; adding said comelt to a second vessel (B) containing water at 50-60°C; and mixing to prepare the conditioning gel phase, wherein the temperature of said mixture of the comelt and the water in the second vessel (B) is controlled such that it is maintained at 56-65°C. Also provided is a process for manufacturing a conditioning composition by forming a conditioning gel phase according to the above process and followed by adding remaining ingredients, such as fragrances, silicones, fibre actives and other benefit agents.
Patent EA-028936-B1 (EA)
Title: Re-useable injector device for syringe
Inventor: COWE TOBY
IPC: A61M5/32
Filed: 2014-03-07
Abstract: An injector device includes an injector body that receives a syringe; and an injection assembly being configured to dispense medicament from the syringe in a dispensation step. Certain types of injector devices include a sudden completion indicator that indicates when the injection is completed. Certain types of injector devices are configured to dispense two different medicament formulations having different viscosities from syringes without making any changes to the injector devices other than to switch out the syringes. Certain types of injector devices include safety arrangements that inhibit firing of the injector device until front and rear housing assemblies are disposed in predetermined rotational and axial positions relative to each other.
Patent EA-034668-B1 (EA)
Title: Method for denitrogenation of natural gas with or without helium recovery
Inventor: BRIGLIA ALAIN
IPC: F25J3/02
Filed: 2014-10-14
Abstract: In a method for denitrogenation of natural gas by distillation, a natural gas (11, 12) cooled in an exchange line (1) is separated in a system of columns including at least one column (2, 3), a nitrogen-enriched gas (18) is drawn from one column (3) of the system of columns and is heated in the exchange line, a methane-enriched liquid (13) is drawn from one column (3) of the system of columns, pressurised and vaporised in the exchange line at at least one vaporisation pressure, and at least one portion of the cooled natural gas expands in gaseous form in a turbine (7) and is sent to the column (2) of the system of columns in gaseous form.
Patent EA-038921-B1 (EA)
Title: Detection of target nucleic acid and variants thereof
Inventor: SAAL LAO HAYAMIZU
Filed: 2016-05-18
Abstract: The invention relates to highly sensitive and specific methods for detection of nucleic acids, which for example are useful for detection of rare mutations, or for detection of low-abundance variants in nucleic acids sequences. The methods involve an asymmetric incremental polymerase reaction (AIPR) followed by an exponential polymerase chain reaction (PCR).
Patent EA-037101-B1 (EA)
Title: 2-(phenyloxy or phenylthio)pyrimidine derivatives as herbicides
Inventor: DEPREZ NICHOLAS RYAN
IPC: C07D239/34
Filed: 2016-06-01
Abstract: Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof:wherein A, Z, R1, R2, R3 and m are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.
Patent EA-037889-B1 (EA)
Title: Method of predetermining the time profile of contrast agent concentration in diagnostic imaging using a magnetic resonance system
Inventor: ROHRER MARTIN
IPC: G01R33/563
Filed: 2016-05-10
Abstract: A method of predetermining the time profile of contrast agent concentration at a position in a blood vessel of a patient in the context of contrast agent-enhanced magnetic resonance (MR) imaging of a region of interest only during an initial flooding-in phase of the contrast agent into the blood vessel situated in the region of interest. The method comprises establishing an expected broadening of a contrast agent bolus profile B(t) according to the equation W=W2-W1, wherein W1 is a first width of the contrast agent bolus profile at a predetermined first vessel position of the patient and W2 is a second width of a contrast agent concentration profile at a predetermined second vessel position situated in the region of interest of the patient. The broadening is established by determining at least one flow parameter which is dependent on at least one blood flow property of the patient at a third vessel position thereof and which correlates with the expected broadening of the contrast agent bolus profile.
Patent EA-034987-B1 (EA)
Title: Process for producing methanol
Inventor: YIU KAR CHI
IPC: C07C29/151
Filed: 2016-12-16
Abstract: A process is described for the synthesis of methanol comprising the steps of: (i) passing a first synthesis gas mixture comprising a make-up gas through a first synthesis reactor containing a cooled methanol synthesis catalyst to form a first product gas stream, (ii) recovering methanol from the first product gas stream thereby forming a first methanol- depleted gas mixture, (iii) combining the first methanol-depleted gas mixture with a loop recycle gas stream to form a second synthesis gas mixture, (iv) passing the second synthesis gas mixture through a second synthesis reactor containing a cooled methanol synthesis catalyst to form a second product gas stream, (v) recovering methanol from the second product gas stream thereby forming a second methanol-depleted gas mixture, and (vi) using at least part of the second methanol-depleted gas mixture as the loop recycle gas stream, wherein the first synthesis reactor has a higher heat transfer per cubic metre of catalyst than the second synthesis reactor, none of the loop recycle gas stream is fed to the first synthesis gas mixture and the recycle ratio of the loop recycle gas stream to form the second synthesis gas mixture is in the range 1.1:1 to 6:1.
Patent ES-2188322-B1 (ES)
Title: Utilizacion de agregados moleculares como refrigerantes magneticos.
Inventor: TEJADA PALACIOS JAVIER
IPC: F25B21/00
Filed: 2000-06-09
Granted: 2004-10-16
Abstract: Utilización de agregados moleculares como refrigerantes magnéticos. Los agregados moleculares de la presente invención presentan aplicación como refrigerantes magnéticos a temperaturas por debajo de 30 K, especialmente a temperaturas inferiores a 10 K. Los agregados moleculares de la invención comprenden átomos de metales enlazados mediante ligandos puente cuya característica común es, por un lado, la existencia de una fuerte interacción magnética de intercambio entre los átomos metálicos de manera que cada molécula posee un elevado valor de espín y momento magnético y, por otro lado, la existencia de una dirección de fácil imantación debido a la simetría de la molécula según la cual se orientan el espín y el momento magnético. Los agregados moleculares de la presente invención son materiales que poseen una elevadísima anisotropía magnética. En los agregados moleculares de la invención, la magnetización presenta un máximo a la temperatura de trabajo o de bloqueo. Además, esta temperatura puede variarse en función del campo magnético aplicado y de la velocidad de barrido del campo.
Patent ES-2161656-B1 (ES)
Title: Inseminacion especifica segun el sexo de mamiferos, con bajo numero de celulas de esperma
Inventor: SEIDEL GEORGE E
IPC: A61D19/02
Filed: 1998-12-31
Granted: 2002-08-01
Abstract: Se consigue inseminación artificial para crías sexadas de mamíferos en una forma práctica comercialmente y con dosis de esperma de inseminación de lo que se creía posible anteriormente para implementación comercial práctica. Los sistemas de inseminación mejorados adaptados especialmente a la utilización para clasificación de esperma seleccionada según el sexo incluyen sistemas que consiguen superovulación y a continuación producción de embriones múltiples con embriones sexados. Estos sistemas se combinan con otras técnicas incluyendo técnicas para disposner un fluido envolvente (3) y otras estrategias que minimizan las solicitaciones sobre las células de esperma (18), y potencialmente una solución envolvente de citrato sódico al 2,9% para especies bovinas y un medio de gameto bovino hepes para especies equinas
Patent ES-2192915-B1 (ES)
Title: Obturador elastomero para revestimientos laterales ajustables de bombas.
Inventor: HILL THOMAS G
IPC: F04D29/42
Filed: 1999-02-02
Granted: 2005-02-16
Abstract: Un miembro obturador elastómero (10), para uso en una bomba que tiene revestimientos laterales ajustables (38, 40), está estructurado con una pestaña (74, 76) del tipo de fuelle que proporciona y mantiene una obturación hermética entre los elementos (14) envolventes adyacentes de la bomba, ya que los revestimientos laterales (38, 40) están ajustados axialmente para compensar el desgaste y la abrasión de los revestimientos laterales. El miembro de obturación elastómero (10) proporciona una obturación continua entre los elementos (14) envolventes adyacentes, ya que los revestimientos laterales (38, 40) están ajustados axialmente, prolongando de este modo la vida de servicio de los revestimientos laterales (38, 40) y extendiendo el número de horas que la bomba puede estar funcionando antes de que se necesite una sustitución de los revestimientos laterales y de la obturación.
Patent ES-2205978-B1 (ES)
Title: Particulas solidas insolubles en agua tratadas, preparacion y utilizacion.
Inventor: THOLON LYSIANE
IPC: A61Q1/10
Filed: 2001-06-29
Granted: 2005-04-01
Abstract: Partículas sólidas insolubles en agua tratadas, preparación y utilización. La presente invención tiene por objeto partículas sólidas insolubles en agua, particularmente pigmentos, que de forma características, están recubiertos con al menos una capa de al menos un producto de reacción entre al menos una molécula capaz de hidratarse en contacto con el agua y con al menos una molécula lipófila. La misma tiene igualmente por objeto composiciones cosmética, farmacéutica y para la agricultura incluyendo tales partículas así como la fabricación y utilización de dichas partículas.
Patent ES-2189682-B1 (ES)
Title: Preparacion bebible que comprende ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamacion y/o dolor, en un colectivo de animales, de forma simultanea.
Inventor: HOMEDES BEGUER JOSEP
IPC: A61K47/32
Filed: 2001-12-11
Granted: 2004-04-01
Abstract: Preparación bebible que comprende ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamación y/o dolor, en un colectivo de animales, de forma simultánea. La preparación bebible comprende agua de bebida para animales o leche artificial para lactantes, suplementada con ketoprofeno, y es útil para el tratamiento por vía oral de procesos que cursan con fiebre, inflamación y/o dolor, de un colectivo de animales, de forma simultánea.