Patent SG-11201406973P-A (SG)
Title: Complement pathway modulators and uses thereof
Inventor: ADAMS CHRISTOPHER MICHAEL
IPC: C07D413/06
Filed: 2013-05-03
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 7 November 2013 (07.11.2013) WIPOIPCT (10) International Publication Number WO 2013/164802 A1 (51) International Patent Classification: C07D 403/06 (2006.01) A61P 27/02 (2006.01) C07D 413/06 (2006.01) A61P 37/00 (2006.01) C07D 417/06 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/053546 3 May 2013 (03.05.2013) English (30) Priority Data: 61/642,798 61/782,820 4 May 2012 (04.05.2012) 14 March 2013 (14.03.2013) English US US (71) Applicant (for all designated States except US): NO­ VARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH). (72) Inventors; and (71) Applicants (for US only): ADAMS, Christopher Mi­ chael [US/US]; Novartis Institutes for BioMedical Re­ search, Inc., 100 Technology Square Cambridge, Cam­ bridge, Massachusetts 02139 (US). BABU, Charles [US/US]; Novartis Institutes for BioMedical Research, Inc., 6201 South Freeway, Fort Worth, Texas 76134 (US). DING, Jian [US/US]; Novartis Institutes for BioMedical Research, Inc., 100 Technology Square Cambridge, Cam­ bridge, Massachusetts 02139 (US). EHARA, Takeru [JP/US]; Novartis Institutes for BioMedical Research, Inc., 100 Technology Square Cambridge, Cambridge, Mas­ sachusetts 02139 (US). JENDZA, Keith [US/US]; No­ vartis Institutes for BioMedical Research, Inc., 100 Tech­ nology Square Cambridge, Cambridge, Massachusetts 02139 (US). JI, Nan [CN/US]; Novartis Institutes for Bio­ Medical Research, Inc., 100 Technology Square Cam­ bridge, Cambridge, Massachusetts 02139 (US). KARKI, Rajeshri Ganesh [IN/US]; Novartis Institutes for BioMed­ ical Research, Inc., 100 Technology Square Cambridge, Cambridge, Massachusetts 02139 (US). KAWANAMI, Toshio [JP/US]; Novartis Institutes for BioMedical Re­ search, Inc., 100 Technology Square Cambridge, Cam­ bridge, Massachusetts 02139 (US). XUE, Liang [US/US]; Novartis Institutes for BioMedical Research, Inc., 6201 South Freeway, Fort Worth, Texas 76134 (US). MAIN- OLFI, Nello [IT/US]; Novartis Institutes for BioMedical Research, Inc., 400 Technology Square Cambridge, Cam­ bridge, Massachusetts 02139 (US). POWERS, James J. [US/US]; Novartis Institutes for BioMedical Research, Inc., 400 Technology Square Cambridge, Cambridge, Mas­ sachusetts 02139 (US). SERRANO-WU, Michael H. [US/US]; Novartis Institutes for BioMedical Research, Inc., 100 Technology Square Cambridge, Cambridge, Mas- [Continued on next page] (54) Title: COMPLEMENT PATHWAY MODULATORS AND USES THEREOF CJ o 00 •t (57) Abstract: The present invention provides a compound of formula I: (I) a method for manufac­ turing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition. (I) WO 2013/164802 A11 lllll llllllll II llllll III lllll lllll lllll III III III lllll lllll lllll llll llll lllll lllllll llll llll sachusetts 02139 (US). ZHANG, Chun [CN/US]; No­ vartis Institutes for BioMedical Research, Inc., 100 Tech­ nology Square Cambridge, Cambridge, Massachusetts 02139 (US). (74) Common Representative: NOVARTIS AG; Lichtstrasse 35, CH-4056 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))