Patent SG-11201910198U-A (SG)
Title: Multibiotic agents and methods of using the same
Inventor: CASEY JR
IPC: A61P13/12
Filed: 2018-06-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 December 2018 (13.12.2018) WIPO I PCT omit VIII °nolo III om Immo IHI 0111 OII 1111111 ois (10) International Publication Number WO 2018/226732 Al (51) International Patent Classification: A61K 31/7034 (2006.01) A61P 13/12 (2006.01) (21) International Application Number: PCT/US2018/036113 (22) International Filing Date: 05 June 2018 (05.06.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/515,409 05 June 2017 (05.06.2017) US 62/613,359 03 January 2018 (03.01.2018) US 62/632,531 20 February 2018 (20.02.2018) US TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) W O 20 18/ 2267 3 2 Al (71) Applicant: FLAGSHIP PIONEERING INNO- VATIONS V, INC. [US/US]; 55 Cambridge Parkway, 8th Floor, Cambridge, MA 02142 (US). (72) Inventors: CASEY, John P.; 1 Goodwin Place #4, Boston, MA 02114 (US). BERRY, David; 155 Beethoven Avenue, Waban, MA 02468 (US). CASTRO, Alfredo; 14 Kelly Dri- ve, Woburn, MA 01801 (US). TAYLOR, Steven J.; 17 Hill Street, Winchester, MA 01890 (US). MASSARI, Fer- dinand E.; 33 Crescent Ave., Beverly, MA 01915 (US). PROUSFOOT, John; 40 Currituck Road, Newtown, CT 06470 (US). BOGART, Elijah; 27 Putnam Ave #2, Cam- bridge, MA 02139 (US). BRIGGS, Timothy F.; 105 Ver- non St., Unit 2, Waltham, MA 02453 (US). (74) Agent: ELBING, Karen L.; Clark & Elbing LLP, 101 Fed- eral Street, 15th Floor, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: MULTIBIOTIC AGENTS AND METHODS OF USING THE SAME (57) : Multibiotic agents are disclosed. The multibiotic agents may contain two or more moieties linked through bonds cleav- able in vivo. The bonds cleavable in vivo can be ester bonds, amide bonds, azo bonds, glycosidic bonds, carbonate linkers, or carbamate linkers. The moieties can be alcohol cores, amine cores, and/or acyls. Also disclosed are compositions containing multibiotic agents and methods of using the multibiotic agents.