baber/WOPTO huggingface dataset:
Patent AT-E367397-T1 (AT)
Inventor: BANERJEE AMIYA
IPC: C12N15/09
Filed: 1998-05-06
Granted: 2007-08-15
Abstract: A system for generating recombinant, human parainfluenza virus, particularly infectious, recombinant, human parainfluenza virus type 3 (HPIV-3) is provided. In one embodiment, the system comprises a clone comprising a nucleotide sequence that encodes a full-length, positive sense, anti-genome of HPIV, and at least one support clone comprising a nucleotide sequence that encodes the HPIV P protein and the HPIV L protein. In another embodiment, the system further comprises a support clone which comprises a nucleotide sequence that encodes the HPIV NP protein. The present invention also provides a MAH clone which comprises a nucleotide sequence encoding the full-length, positive sense, anti-genome of HPIV-3. The clone also comprises an RNA polymerase promoter operatively linked to the HPIV-3 antigenome-encoding sequence. In a preferred embodiment, the clone further comprises a nucleotide sequence which encodes a ribozyme immediately downstream from the sequence encoding the HPIV-3 anti-genome. The present invention also relates to a method of preparing recombinant HPIV-3 virus having site-specific mutations in the HPIV-3 genome. The method comprises preparing a clone comprising a modified HPIV-3 antigenome-encoding sequence; introducing the modified HPIV-3 clone and support clones which comprise nucleotide sequences encoding an HPIV-3 P protein, an HPIV-3 L protein, and, preferably, an HPIV-3 NP protein into host cells; and culturing the host cells under conditions that allow for synthesis of the modified HPIV-3 antigenome and the L, P, and NP proteins of HPIV-3.
Patent AT-E238794-T1 (AT)
Inventor: MEERT THEO FRANS
IPC: C07D241/04
Filed: 1998-06-09
Granted: 2003-05-15
Abstract: This invention concerns the use of nucleoside transport inhibitors, more particularly compounds of formulaan N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein R1 is C1-4alkyl, aminocarbonyl or mono- or di(C1-4alkyl)aminocarbonyl, Ar is a phenyl or pyridinyl derivative and L is a radical of formulawherein Ar1 is a phenyl derivative; Ar2 is a phenyl or pyridinyl derivative; and Alk is C1-4alkanediyl; for the manufacture of a medicine for the treatment of warm-blooded animals suffering from pain.
Patent AT-E206293-T1 (AT)
Inventor: KIM HYUNG WOOK
IPC: A23L27/00
Filed: 1998-10-07
Granted: 2001-10-15
Abstract: A process for the preparation of a substantially free flowing particulate flavor by mixing an oil soluble flavor with a melted edible fat having a melting point from about 30° C. (85° F.) to 93° C. (200° F.) to form a solution of the oil soluble flavor in the melted fat, cooling the solution of the oil soluble flavor in the melted fat, with the addition of a super-cooling agent with agitation during cooling, to produce solid particles having an average diameter of from about 0.1 to 10 cm, and then, if desired, grinding these particles with a super-cooling agent to produce the substantially free flowing particulate flavor whose particles have an average diameter of less than 1 mm.
Patent AT-E452144-T1 (AT)
Inventor: KLEHR NIKOLAUS W
IPC: A61K38/19
Filed: 1998-10-23
Granted: 2010-01-15
Abstract: A method for preparing autologous human blood cytokines comprises: (a) treating whole blood from a donor to separate a preparation comprising white blood cells, plasma and an antigen especially tumour cells from erythrocytes; (b) dividing the preparation into first and second aliquots; (c) demasking the cells in the first aliquot rendering the tumour cells recognisable as foreign by the donor's immune system; and (d) incubating the first aliquot with the second aliquot. Also claimed is a cytokine-containing product obtained by the above method.
Patent AT-E318300-T1 (AT)
Inventor: TRAININ ZE EV
IPC: A61K39/085
Filed: 1998-12-29
Granted: 2006-03-15
Abstract: The invention provides antigenic compositions for the vaccination of an animal against bovine mastitis caused by infection with Staphylococcus aureus. The invention also provides methods for stimulating an animal's immune system to respond to antigens derived from selected strains of Staphylococcus aureus by administering the antigenic compositions of the invention to the animal.
Patent AT-E337139-T1 (AT)
Inventor: KREITZBERG JOHN S
IPC: F16B21/12
Filed: 1998-12-11
Granted: 2006-09-15
Abstract: An improved locking pin for locking together two pieces of equipment through aligned locking apertures. The pin comprises a steel casing, a steel insert and an elastomer member. The two steel parts assemble together in a particular sequence and are adjusted so that when completely assembled, the insert is locked into the casing with the body of the casing and the insert being parallel and spaced from one another. The elastomer member is interposed in the space defined between the casing and insert, and fills the space between the steel parts. The assembled steel parts are firmly locked together by introduction of the elastomer member into that space. There is no adhesive joining the steel and elastomer members which makes the pin more amenable for use in corrosive environments and also eases manufacture of the pin components. A tightly constructed locking pin also avoids the problems of the components becoming loose or lost.
Patent AT-E280923-T1 (AT)
Inventor: SCHAADT DIETER B
IPC: F16M13/00
Filed: 1999-03-05
Granted: 2004-11-15
Abstract: The arrangement has a transverse part (3) in the form of a toothed rod with attachment parts (4) on its ends and a block (5) which can be adjusted on the transverse element in the longitudinal direction of the transverse element. The block has holders (6) for the plate-shaped elements.
Patent AT-E260382-T1 (AT)
Inventor: DEUTSCHLE BRUNO
IPC: E04B2/96
Filed: 1999-04-26
Granted: 2004-03-15
Abstract: The material of the screw channel (14) has a lesser commencement strength and/or a lesser cold fixture degree and/or a lesser cold rolling degree. The material of the screw channel is hot-rolled. The screw channel is formed from flat material, angle profiles, a U-profile (20) and/or a W-profile and is welded to the support profile (12).
Patent AT-E338246-T1 (AT)
Inventor: WALDMANN GERHARD
IPC: F21V7/00
Filed: 1999-04-16
Granted: 2006-09-15
Abstract: The light has an elongated housing symmetrical wrt. a vertical plane, transparent for downward light emanation and open at the top. Two light tubes (28) are mounted in the housing at equal distances on both sides of the centre plane. At least one reflector (30) is mounted in the housing near each light tube to deflect the light at least partly upwards. Each reflector is a holed plate with a vertical section (32) on one side of the light tube, an approximately horizontal section (34) above the tube and a third section (36) inclined upwards from the centre plane.
Patent AT-E216212-T1 (AT)
Inventor: TIAN ENRICO
IPC: A61F2/00
Filed: 1999-05-10
Granted: 2002-05-15
Abstract: An antiluxation hip prosthesis having a hollow ring nut which can be secured to the pelvis and delimits a receiving seat, a cotyloid cavity or acetabular insert which can be accommodated in the receiving seat and delimits a substantially hemispherical seat, a spherical head of an artificial femur which can be located in the seat of the cotyloid cavity and a flange which can be inserted onto the femur to abut against its spherical head and rigidly coupled to the cotyloid cavity to keep the artificial head permanently in the seat so that it is free to perform articulated movements therein. <IMAGE>
Patent AT-E217171-T1 (AT)
Inventor: VILOZNI DAPHNA
IPC: A61B5/00
Filed: 1999-06-14
Granted: 2002-05-15
Abstract: The expired gases of an individual (P) are measured (M) as a number of functions that are displayed (D) and fed to PID controllers/filters (PID). The signals are also received by a controller (A) where they are analyzed and entered into memory. The lung function performance is displayed (O) for observation by the individual.
Patent AT-E221428-T1 (AT)
Inventor: DI ROSA GAETANO
IPC: B23K9/173
Filed: 1999-11-03
Granted: 2002-08-15
Abstract: A welding electrode dressing device in particular in automated welding stations comprises an electrode treatment head (11, 111) equipped with upsetting members (15, 115) which reshape the tip of an electrode inserted in it without removing material. Advantageously the treatment head (11, 111) comprises two treatment seats (19, 119) arranged on opposite sides thereof to each receive the end (12) of a pair of welding gun electrodes. <IMAGE>
Patent AT-E316168-T1 (AT)
Inventor: GRAFF PIERRE
IPC: B31F1/07
Filed: 1999-02-05
Granted: 2006-02-15
Abstract: The domestic two-ply absorbent paper material, with an embossed patterning and in a weight of 10-40 g/m<2>, has a raised point density in each ply of ≥ 10 points/cm<2>, and the surface area of the raised points in each ply is ≥ 5% of the ply surface. At least one ply is embossed with a decorative pattern, with structured projection gaps and angles, which match up with the embossed projections of the other ply. The total surface of the peaks of the projections, bonded together, are at least 15% of the total projection peak surface area of the ply, at the relative positions for the pattern of the two plys. At least 30% or 40% of the embossed projections of one ply form bonds with the embossed projections of the other ply. The total surface of the projection peaks, in a ply, is at least equal to 20% of the projection surfaces of the ply, and is ≤ 30% of the ply surface area and ≥ 7.5% of the ply surface while ≤ 15%. The projection density is preferably ≤ 20 projections/cm<2>. Both plys are embossed with a decorative pattern which can be identical and offset, or different.
Patent AT-E272978-T1 (AT)
Inventor: HALLIBERT PASCAL
IPC: A61B/
Filed: 1999-01-20
Granted: 2004-08-15
Abstract: The invention concerns a device for taking prints of skin tissues comprising an optical sensor (10) with an object surface (12) for receiving tissues whereof the print has to be taken and, on a fraction of the object surface, a thin transparent electrode coated with an electroluminescent dielectric layer (34). Means provide difference of potential between the tissues pressed on the sensitive layer and the transparent electrode and other means (22) form an image of the tissues pressed on the object surface, including said fraction. The imaging means provide an electronic treatment of the image which enables identification or verification by comparing with one or several stored prints by verifying the continuity of relief on the fraction and the remainder of the object surface.
Patent AT-E329007-T1 (AT)
Inventor: HANAK JULIAN ALEXIS JOHN
IPC: C12N15/09
Filed: 1999-04-13
Granted: 2006-06-15
Abstract: The invention relates to host cells and methods of preparing a substantially RNA-free cellular component, comprising culturing cells producing the cellular component in a medium and lysing the cells to produce a cell lysate, wherein the cell lysate contains the cellular component and sufficient RNase activity to degrade substantially all of the RNA molecules present in the cell lysate. The invention also relates to substantially RNA-free cellular components.
Patent AT-E306666-T1 (AT)
Inventor: WILDSMITH SOPHIE ELIZABETH VIC
IPC: G01N33/53
Filed: 1999-07-29
Granted: 2005-10-15
Abstract: A method for analyzing the protein or peptide content of a mixture comprising exposing a spatial array of protein recognition units to the protein or peptide containing mixture, and detecting the binding of proteins or peptides to the protein recognition units.
Patent AT-E225818-T1 (AT)
Inventor: FROHAUG ASTRID
IPC: C08J3/12
Filed: 1999-08-20
Granted: 2002-10-15
Abstract: The invention provides a process for the preparation of a moulded polymer item, said process comprising obtaining a polymer moulding powder having a mean particle size of 1 to 2000 mum comprising an admixture of UV-stabilizer-loaded polymer particles and non-UV-stabilizer-loaded polyolefin polymer particles, loading said powder into a mould, heating and rotating said mould to melt said powder, cooling said mould, and releasing said moulded polymer item from said mould.
Patent AT-E240176-T1 (AT)
Inventor: LASALLE JERRY
IPC: B22F3/02
Filed: 1999-08-19
Granted: 2003-05-15
Abstract: A molding compound consisting of the nickel superalloy Hastelloy X is used to form net-shape or near net-shape articles. The compound, containing atomized Hastelloy X powder having an average particle size less than about 20  mu m, is mixed with a liquid carrier, a gel forming binder and processing additives and molded at relatively low pressures in a conventional injection molding machine. A critical air debinding step prior to sintering results in high densification of the article, which has mechanical properties comparable to cast or wrought processed material.
Patent AT-E261752-T1 (AT)
Inventor: EYSSEL MARCUS
IPC: B01D27/06
Filed: 1999-10-15
Granted: 2004-04-15
Abstract: The invention relates to a method which is provided for producing filter cartridges (10) comprising at least one film end disc (11) and which makes it possible to introduce inserts with a high level of positional accuracy. To this end, receptacles (17, 23) are provided in a mold (12), in which the inserts (13, 15) are inserted and can be fixed in the positions thereof. Afterwards, the film blanks (14) are heated in a conventional manner, expand, and as a result, fix the introduced filter medium (16) of the filter cartridge and the inserts (13, 15). In doing this, complicated functional parts can be introduced into the film end discs (11) of filter cartridges (10) without requiring a large amount of effort with regard to manufacturing techniques.
Patent DE-1240841-T1 (DE)
Inventor: GUYARD JEAN-PIERRE
IPC: A44C5/24
Filed: 2001-03-12
Abstract: The folding clasp for an interchangeable watch strap comprises at least two arms articulated together and foldable against each other, provided with a fixing device to hold the clasp in closed position. The free end of one (1) of the arms (1, 3) is provided with a securement device for the end of a strap tongue (11) comprising a guide (8) having in cross-section a general U shape, an axle (9) connecting the two lateral wings of the guide (8) and holding members (10) adapted to coact with the upper surface of the tongue (11) of the strap. The free end of the other arm (3) of the clasp is pivoted on a cover (14) with the help of a screw (12), this cover (14) having lateral portions (13) interconnected by an axle (15). The cover (14) of the clasp comprises retaining members (16) adapted to coact with the upper surface of a second tongue (17) of the strap.
Patent DE-15775762-T1 (DE)
Title: Konzentriertes extrakt von algen, herstellungsverfahren dafür und verwendung davon in der landwirtschaft
Inventor: HERY PAUL
IPC: A01P17/00
Filed: 2015-09-11
Abstract: Konzentrierter Algenextrakt, dadurch gekennzeichnet, dass er einen Prozentsatz an Trockensubstanz zwischen 6 und 100 %, vorzugsweise zwischen 9 und 70 %, stärker bevorzugt zwischen 12 und 50 % aufweist und dass er 0 bis 5 Gew.-%, insbesondere 1 bis 4 Gew.-%, stärker bevorzugt 2 bis 3 Gew.-% Alginat und/oder Cellulose, bezogen auf das Gewicht des Extrakts, enthält.
Patent DE-574579-T1 (DE)
Inventor: WEINSHANK RICHARD
IPC: C07K14/00
Filed: 1993-01-08
Abstract: PCT No. PCT/US93/00149 Sec. 371 Date Aug. 22, 1994 Sec. 102(e) Date Aug. 22, 1994 PCT Filed Jan. 8, 1993 PCT Pub. No. WO93/14201 PCT Pub. Date Jul. 22, 1993This invention provides an isolated nucleic acid molecule encoding a human 5-HT1F receptor, an isolated protein which is a human 5-HT1F receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT1F receptors, mammalian cells comprising such vectors, antibodies directed to the human 5-HT1F receptor, nucleic acid probes useful for detecting nucleic acid encoding human 5-HT1F receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human 5-HT1F receptor, pharmaceutical compounds related to human 5-HT1F receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human 5-HT1F receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human 5-HT1F receptor.
Patent ES-2052486-T1 (ES)
Inventor: VAN DER DOES HENDRIK JOHN
IPC: B08B9/04
Filed: 1991-08-29
Abstract: PCT No. PCT/NL91/00160 Sec. 371 Date Feb. 25, 1993 Sec. 102(e) Date Feb. 25, 1993 PCT Filed Aug. 29, 1991 PCT Pub. No. WO92/04136 PCT Pub. Date Mar. 19, 1992.A treatment element is provided for treating the inside of pipes, which element is bulged out by a medium flow presence in the pipe (1), while the movement of the element through the pipe can be controlled by a flexible pulling element. This treatment element (2) comprises a radially free compressible bag, the edge (5) of the open edge (6) of which is connected to the flexible pulling element (4). A wall pan (3) running in the peripheral direction of the bag is pressed against the inner wall of the pipe by the thrust of the medium, through which the inner wall is treated.
Patent ES-2135364-T1 (ES)
Title: Pieza postiza de corte revestida con un sustrato de porosidad c que tiene enriquecimiento con aglutinante de superficie no estratificado.
Inventor: GRAB GEORGE P
IPC: B23B27/14
Filed: 1997-07-18
Abstract: LA INVENCION SE REFIERE A UN ACCESORIO CORTANTE QUE COMPRENDE UNA CARA INCLINADA Y UNA CARA LATERAL EN LA QUE SE DISPONE UN BORDE CORTANTE, EN LA UNION DE LA CARA INCLINADA Y LA CARA LATERAL. EL ACCESORIO DE INSERCION CORTANTE PRESENTA UN REVESTIMIENTO Y UN SUSTRATO AL CUAL ESTA UNIDO DICHO REVESTIMIENTO. EL SUSTRATO ES UN CARBURO CEMENTADO A BASE DE CARBURO DE TUNGSTENO, EN EL QUE EXISTE UNA ZONA ENRIQUECIDA EN COBALTO NO ESTRATIFICADO, QUE COMIENZA CERCA DE LA SUPERFICIE PERIFERICA DEL SUSTRATO Y SE EXTIENDE HACIA EL INTERIOR. EL SUSTRATO BRUTO PRESENTA UNA POROSIDAD SUPERIOR A LA DEL COO E INFERIOR O IGUAL A LA DEL CO 2 .
Patent CY-1107341-T1 (CY)
Inventor: FITZPATRICK P JOHN
IPC: F17C1/00
Filed: 2005-09-12
Abstract: A marine gas storage and transport system formed of small diameter steel pipe, which is coiled and stacked in a specific manner. The system is suitable for use on top of a barge or inside the holds of a ship, when contained within a secondary containment system. Various ways of stacking and coiling coiled pipe are disclosed. Specific materials for making the pipe are also disclosed.
Patent CY-1110359-T1 (CY)
Title: Εμβολια με βαση σιρκοϊους χοιρων
Inventor: ALLAN GORDON
IPC: C12N15/34
Filed: 2005-10-07
Abstract: Η παρούσα εφεύρεση έχει σχέση με στελέχη σιρκοϊού χοίρου που απομονώνονται από πνευμονικά και γαγγλιακά δείγματα που προέρχονται από ζώα εκτροφής που έχουν προσβληθεί από το σύνδρομο του γενικευμένου μαρασμού μετά τον απογαλακτισμό (στα αγγλικά PMWS). Αναφέρεται επίσης σε καθαρισμένα παρασκευάσματα των στελεχών αυτών, σε κλασικά εμβόλια εξασθενημένα ή αδρανοποιημένα, σε ζωντανά ανασυνδυαστικά εμβόλια, σε πλασμιδικά εμβόλια και σε εμβόλια υπο-μονάδων, όπως επίσης σε αντιδραστήρια και μεθόδους διάγνωσης. Έχει σχέση επίσης με DNA κομμάτια που μπορούν να χρησιμοποιηθούν για την παραγωγή υπο-μονάδων σε ένα ενδιάμεσο ξενιστή έκφρασης in vitro ή ως αλληλουχίες προς ενσωμάτωση μέσα σε ένα ενδιάμεσο ξενιστή έκφρασης in vivo τύπου ιού ή πλασμιδίου.
Patent CY-1108512-T1 (CY)
Title: Μεθοδος και τυποποιημενη συσκευασια για ανιχνευση της αλκαλικης σφιγγομυελινασης
Inventor: DE SIMONE CLAUDIO
IPC: G01N33/48
Filed: 2008-11-13
Abstract: Μια αναλυτική φθορισμομετρική μέθοδος και μια τυποποιημένη συσκευασία για χρήση σε μια τέτοια μέθοδο αποκαλύπτονται, για προσδιορισμό της παρουσίας αλκαλικής σφιγγομυελινάσης (SMάσης) στα κόπρανα ενός ασθενούς που χρειάζεται έναν τέτοιο προσδιορισμό αφού η αλκαλική SMάση είναι δείκτης σοβαρών παθολογικών καταστάσεων, όπως καρκίνου του κόλου.
Patent CY-1109608-T1 (CY)
Inventor: ERNST UWE
IPC: B01J20/26
Filed: 2009-06-10
Abstract: Adsorbent for organic compounds from an aqueous environment consists of powdered rubber containing natural or synthetic, org or inorganic filler. Independent claims are also included for: (a) adsorbent for organic compounds emulsified, dissolved or floating in water; (b) a method for adsorption of organic compounds emulsified, dissolved or floating in water by adding the filled rubber pow and then separating the adsorbent.
Patent CY-1111457-T1 (CY)
Inventor: ZINSER HARTMUT BURGHARD
IPC: C07C311/18
Filed: 2011-05-16
Abstract: A process for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives in which a (1-benzyl-2-hydroxy-3-isobutylamino-propyl)-carbamic acid derivative is reacted with a p-nitrophenylsulfonyl halide to provide the desired product in a high yield and degree of purity.
Patent CY-1116885-T1 (CY)
Inventor: Oberbörsch Stefan
IPC: C07C251/42
Filed: 2011-11-02
Abstract: Novel cyclohexylmethyl compounds corresponding to formula I wherein R1, R2, R3, R4 and R5, have the meanings given in the description. Pharmaceutical formulations containing these compounds, as well as a processes for preparing these compounds and related methods of treatment are also provided.
Patent CY-1118537-T1 (CY)
Title: Φακετοπερανη για την αγωγη της διαταραχης ελλειμματικης προσοχης - υπερκινητικοτητας
Inventor: KONOFAL ERIC
IPC: A61P25/00
Filed: 2016-12-30
Abstract: Η εφεύρεση αφορά την αγωγή της διαταραχής ελλειμματικής προσοχής-υπερκινητικότητας (ADHD) με τη βοήθεια α-φαινυλ (πιπεριδιν-2-υλ) μεθανόλης, ή φαρμακευτικά αποδεκτών αλάτων και εστέρων της, ιδιαίτερα δε το οξεικό παράγωγο και ειδικότερα την δεξτροφακετοπεράνη. Η εφεύρεση παρέχει αφ' ετέρου μια μέθοδο σύνθεσης του εναντιομερούς (S,S) της α-φαινυλ (πιπεριδιν-2-υλ) μεθανόλης καθώς και μια μέθοδο σύνθεσης της δεξτροφακετοπεράνης.
Patent CY-1118468-T1 (CY)
Title: Ενωσεις δικυκλικης ουριας, θειοουριας, γουανιδινης και κυανογουανιδινης χρησιμες για την αγωγη του πονου
Inventor: ALLEN SHELLEY
IPC: C07D453/02
Filed: 2017-01-18
Abstract: Ενώσεις του Τύπου I: ή στερεοϊσομερή, ταυτομερή ή φαρμακευτικά αποδεκτά άλατα, προϊόντα επιδιαλύτωσης ή προφάρμακα αυτών, όπου ο Δακτύλιος Α, Δακτύλιος C και Χ είναι όπως ορίζεται εδώ, είναι αναστολείς της κινάσης TrkA και είναι χρήσιμες εις την αγωγή νοσημάτων τα οποία μπορούν να υποβληθούν σε αγωγή με έναν αναστολέα κινάσης TrkA όπως πόνος, καρκίνος, φλεγμονή/φλεγμονώδη νοσήματα, νευροεκφυλιστικά νοσήματα, συγκεκριμένα μολυσματικά νοσήματα, σύνδρομο Sjogren, ενδομητρίωση, διαβητική περιφερική νευροπάθεια, προστατίτιδα και σύνδρομο πυελικού πόνου.
Patent CY-1121372-T1 (CY)
Title: Μεθοδος για την παρασκευη καθαρισμενων ανσαμιτοκινων
Inventor: WIDDISON WAYNE C
IPC: C12P17/16
Filed: 2019-02-13
Abstract: Μία μέθοδος για τη μεγάλης κλίμακας ζύμωση εξαιρετικά παραγωγικών στελεχών τα οποία παράγουν ανσαμιτοκίνη. Μία μέθοδος για την απομόνωση ακάθαρτων ανσαμιτοκινών. Μία μέθοδος για τον καθαρισμό ανσαμιτοκινών.
Patent GR-960300006-T1 (GR)
Title: Alkaloids from mappia foetida, the use thereof and formulations containing them.
Inventor: BOMBARDELLI EZIO
IPC: A61P31/22
Filed: 1996-02-29
Abstract: The present invention relates to novel alkaloids from Mappia foetida, foetidine 1 and 2, having anticancer and antiviral properties. These alkaloids, soluble in water, are present in all the parts of the plant, and are the precursors of camptothecin and of 9-methoxy-camptothecin, which are alkaloids known to have pharmacodynamic properties but also to be insoluble in water. The particular water solubility of the novel compounds make them particularly suitable for the treatment of the patients by the parenteral route, avoiding the use of toxic excipients or of unsuitable chemical derivatizations.