baber/WOPTO huggingface dataset:
Patent CA-2272273-C (CA)
Inventor: NYCZ COLLEEN M
IPC: C12Q1/6851
Filed: 1999-05-18
Granted: 2008-12-09
Abstract: Methods for determining quantities of nucleic acid sequences in samples undergoing amplification utilize amplification ratio estimates (R*) in operations to accurately perform absolute quantitation even when amplification factors for the target and control sequences undergoing amplification are different, time dependent or vary as a function of starting concentrations of nucleic acid sequences. These operations also take into account conversion efficiencies associated with the conversion of probes upon generation of target or control amplicons, but do not require the explicit calculation of such efficiencies. The operations also recognize that a preferred R* should be determined based on a preferred statistical criterion to improve quantitation. In addition, the use of standard samples having known starting concentrations of target and control sequences therein may enable accurate absolute quantitation without the explicit calculation of amplification ratio estimates.
Patent CA-2286397-C (CA)
Inventor: BACA MANUEL
IPC: A61K39/395
Filed: 1998-04-03
Granted: 2011-02-15
Abstract: Described herein is a humanized antibody to vascular endothelial growth factor (VEGF). Also described herein is a method for rapidly producing and identifying framework mutations which improve the binding of humanized antibodies to their cognate antigens. In a preferred embodiment, non-human CDRs are grafted onto a human V1.kappa.I-V H III  framework. Random mutagenesis of a small set of critical framework residues is also performed followed by monovalent display of the resultant library of antibody molecules on the surface of filamentous phage.  The optimal framework sequences are then identified by affinity-based selection. Optionally, the selected antibodies can be further mutated so as to replace vernier residues which sit at the V L-V H interface by residues which match the non-human parent antibody. The methods described herein can be applied to any non-human antibody. Accordingly, humanized antibodies are provided.
Patent CA-2290703-C (CA)
Inventor: SEKINE MASAYUKI
IPC: G01C21/26
Filed: 1997-02-03
Granted: 2002-05-14
Abstract: A method and apparatus for selecting a destination in a vehicle navigation system are described. The vehicle navigation system includes a display and a selection control. A first destination is selected from a primary list of destinations in response to a selection signal generated by the selection control. The first destination is placed on a secondary list of destinations in response to its selection.      The secondary list includes previously selected destinations from the primary list. For subsequent destination selections, the primary and secondary lists are presented on the display thereby facilitating selection of destinations from both the primary and secondary lists. A feature by which the system may search for a destination across categories is also described.
Patent CA-2300021-C (CA)
Title: Knocking activated device and method for operating an electromechanical device responsive to a control signal
Inventor: LAROCHE ANDRE
IPC: B60R25/00
Filed: 2000-02-25
Granted: 2005-12-27
Abstract: An object of the present invention is to provide a knocking activated device for operating an electromechanical device responsive to a control signal. The knocking activated device comprises a vibration transducer for generating a signal in response to knockings on a solid object. It also comprises a storing system for storing data representative of a predetermined sequence of knocks.  The device further comprises a user operable interface for changing the data stored in the storing means. The device also comprises comparing system for comparing the signal generated by the vibration transducer with the data stored in the storing means to produce the control signal when the signal generated by the vibration transducer matches the predetermined sequence of knocks. Another object of the present invention is to provide a method for operating the electromechanical device responsive to the control signal
Patent CA-2300931-C (CA)
Inventor: SPINOZA MARC HOWARD
IPC: A61B17/34
Filed: 1998-08-20
Granted: 2011-01-04
Abstract: A method of securing a line (25) to a patient or of adjusting the position of a line (25) thus secured comprises elongating and narrowing a sleeve (20) applied to the line to grip the line and resist movement of the line along its longitudinal axis with respect to the sleeve. Also disclosed is a fastener (19) for securing a line (25) to a patient, the fastener comprising a sleeve (20) of variable length capable when lengthened of gripping the line.
Patent CA-2303853-C (CA)
Title: Acl fixation pin and method
Inventor: CLARK RON
IPC: A61B17/58
Filed: 1998-09-24
Granted: 2007-01-30
Abstract: A pin (20) and method for use are provided for securing a replacement ligament (24) inside a tunnel (10) of a receptor bone (36). A threaded section (30) of the pin (20) engages and anchors the pin (20) in the receptor bone (36). A first taper (26) opposite the threaded section (30) is configured to enter a drilled hole (14) which is transverse to the tunnel (10), capture a looped replacement ligament (24), and extend into the medial side (25) of the receptor bone (36). A second taper (28) urges the replacement ligament (24) against the wall (15) of the tunnel (10) and provides resistance when the second taper (28) contacts the medial side (25) of the bone (36), thus signaling that the pin (20) has been inserted to the proper depth. The body (21) of the pin (20) secures the looped replacement ligament (24) in the tunnel (10) and holds the replacement ligament (24) in contact with the wall (15) of the tunnel (10) to insure ingrowth.
Patent CA-2308881-C (CA)
Title: Electrosurgery system and method
Inventor: GOBLE COLIN CHARLES OWEN
IPC: A61B18/12
Filed: 2000-05-19
Granted: 2012-07-24
Abstract: An electrosurgical generator has output terminals for connection to active and return electrodes respectively of an electrosurgical instrument and, connected to the output terminals via at least one isolation capacitor, a radio frequency (r.f.) source which may be pulsed by a pulsing circuit. To permit tissue removal at a high rate, the source and the pulsing circuit are arranged so as to generate a pulsed r.f. output signal having a peak-to-peak voltage of at least 1250V, a mark-to-mark space ratio not more than 1:1, and a pulse length not more than 100 µs.
Patent CA-2311508-C (CA)
Title: Device and method for implementing handoff in mobile communication system
Inventor: CHOI HO-KYU
IPC: H04W72/04
Filed: 1999-09-27
Granted: 2004-02-10
Abstract: A handoff implementing device and method in a mobile communication system. The handoff implementing device including a base station transmitter and a mobile station receiver. The base station transmitter divides a given frame period into a transmission period and a non-transmission period, separates frame data in the frame period into first and second data, spreads the first and second data by different orthogonal codes, and transmits the spread signal in the transmission period. The mobile station receiver receives the first and second data spread by the different orthogonal codes in the transmission period, assembles the first and second data into the frame data, and searches for an adjacent base station to which a call is handed off in the non-transmission period.
Patent CA-2312272-C (CA)
Inventor: TRUAX DAVID
IPC: E21B10/46
Filed: 2000-06-23
Granted: 2006-10-03
Abstract: A bi-center drill bit includes pilot and reaming blades affixed to a body at azimuthally spaced locations. The blades have PDC cutters attached at selected positions.  In one aspect, the pilot blades form a section having length along the bit axis less than about 80 percent of a diameter of the section. In another aspect, selected pilot blades and corresponding reaming blades are formed into single spiral structures. In another aspect, shapes and positions of the blades and inserts are selected so that lateral forces exerted by the reaming and the pilot sections are balanced as a single structure. Lateral forces are preferably balanced to within 10 percent of the total axial force on the bit. In another aspect, the center of mass of the bit is located less than about 2.5 percent of the diameter of the bit from the axis of rotation. In another aspect, jets are disposed in the reaming section oriented so that their axes are within about 30 degrees of normal to the axis of the bit. In another aspect, the reaming blades are shaped to conform to the radially least extensive, from the longitudinal axis, of a pass-through circle or a drill circle, so the cutters on the reaming blades drill at the drill diameter, without contact to the cutters on the reaming blades when the bit passes through an opening having about the pass-through diameter.
Patent CA-2313493-C (CA)
Title: Method and apparatus for freezing products
Inventor: WILLIAMS MARK SHERMAN
IPC: F25B27/00
Filed: 2000-07-10
Granted: 2007-09-25
Abstract: A method of freezing a product, which method comprises the steps of vaporising a cryogenic liquid and warming the vapour thus formed in indirect heat exchange with a product to be frozen, work expanding the warmed vapour, and using the work expanded vapour thus obtained to refrigerate the or another product.
Patent CA-2318853-C (CA)
Inventor: DOWNIE ANDREW
IPC: E21B4/16
Filed: 1999-01-20
Granted: 2007-08-21
Abstract: There is disclosed an improved downhole steerable motor assembly (5) and related method. A problem in known assemblies is that the distance from a bent housing bend ax is to the face of a drill bit needs to be kept relatively short resulting in the length of the bearing package and its thrust capacity being restricted. Accordingly, the invention provides a downhole motor assembly (5 ) comprising a motor (115), at least one thrust bearing (116) and a bent portion (117), the assembly (5) having a first end (135) and a second end (140), the first end (135) being closer to surface than the second end (140), in use, wherein the bent portion (117) is closer to the second end (140) than is the at leas t one thrust bearing (116).
Patent CA-2319665-C (CA)
Inventor: HEATH ELLEN M
IPC: C12N15/09
Filed: 1999-02-02
Granted: 2010-06-29
Abstract: Processes for isolating and amplifying DNA from biological materials are provided.
Patent CA-2328060-C (CA)
Inventor: TSUKADA MASUHIRO
IPC: C07K14/435
Filed: 2000-05-26
Granted: 2004-10-26
Abstract: The present invention provides a gene Any-RF derived from an insect, having dormancy-control activity and biological cell-control function; a dormancy-control substance and a method for preparing the same; as well as a biological cell-control agent, which comprises, as an effective component, a physiologically active substance having a biological cell-control function and which never causes any antigen-antibody reaction in the living body.      The gene encodes for a protein having an amino acid sequence specified as Sequence No. 1 in SEQUENCE LISTING: Asp-Ile-Leu-Arg-Gly, whose C-terminal is amidated and having a molecular weight of 570.959. The physiologically active substance comprising such a gene is a peptide, which can be isolated and purified by adding an acid-methanol aqueous solution to Antheraea yamamai, triturating the resulting mixture, centrifuging the same and then treating the resulting supernatant in an HPLC system. The peptide permits the control of the dormancy of insects and is also useful as a biological cell-control agent, which comprises, as an effective component, such a peptide.
Patent CA-2330237-C (CA)
Inventor: DOETSCH PAUL W
IPC: A61P35/00
Filed: 1999-06-08
Granted: 2010-05-25
Abstract: La présente invention concerne des endonucléases de lésion de l'ADN présentant une large spécificité par rapport aux types d'aberrations de structure dans un ADN double brin. Ces enzymes reconnaissent un ADN double brin présentant des distorsions dans sa structure, les distorsions résultant de photoproduits, d'une alkylation, d'une insertion, de sites abasiques, de paires de bases non correspondantes, de composés d'addition de cisplatine et de bases à incorporation inadéquate (par exemple 8-oxoguanine, inosine, xanthine, notamment). L'invention concerne également l'UVDE (Uve1p) de Schizosaccharomyces pombe, certaines formes tronquées de l'UVDE (auxquelles il manque environ entre 100 et 250 acides aminés de la séquence N-terminal) et certaines endonucléases provenant de Homo sapiens, Neurospora crassa, Bacillus subtili et de Deinococcus radiodurans. La présente invention concerne en outre des méthodes de clivage d'un ADN double brin présentant des distorsions de structure telles que celles invoquées ici, les méthodes consistant à utiliser les endonucléases prises comme exemples ou leurs dérivés tronqués stables et fonctionnels.
Patent CA-2335018-C (CA)
Title: Codes d'etalement de phase quadrivalente dans des communications a acces multiple par code de repartition
Inventor: POPOVIC BRANISLAV M
IPC: H04J13/18
Filed: 1999-06-11
Granted: 2009-09-29
Abstract: Des séquences codées optimisées sont générées afin d'être mises en application dans des fonctions d'étalement et de désétalement dans un système de communications à accès multiple par code de répartition (AMCR). On utilise, en particulier, une famille de codes d'étalement de phase quadrivalente permettant d'obtenir un nombre maximum de codes d'étalement, de manière à atteindre une capacité élevée dans le système AMCR, tout en présentant simultanément une corrélation croisée minimum de pointe entre deux codes d'étalement de cette famille afin de maintenir toute interférence de corrélation croisée à un niveau égal ou inférieur à des niveaux acceptables. Cette famille de codes est la famille S(2) comportant des séquences codées de phase quadrivalente de longueur L = 2<m-1>, dans laquelle m est un entier supérieur ou égal à 5. La dimension de cette famille S(2) de codes d'étalement quaternaires correspond à (L+2)(L+1)<2> et la corrélation croisée maximum est 1+4 2ROOT (L+1). Ces codes d'étalement sont, de préférence, affectés à des stations de base mettant en application des sous-ensembles de codes spécifiques de la famille S(2) possédant les mêmes propriétés de corrélation croisée que les familles de codes S(0) et/ou S(1). Ces codes d'étalement sont avantageusement complétés par un ou plusieurs symboles codés si nécessaire. Par exemple, dans le but d'appuyer des services à vitesse de transmission variable, il est désirable d'utiliser des codes d'étalement dont la longueur peut être exprimée sous forme de multiple entier de chaque facteur d'étalement dans le système de communications mobile. Etant donné que les codes d'étalement individuels possèdent une longueur de 2<m>-1, on ajoute un symbole codé au code d'étalement généré.
Patent CA-2341712-C (CA)
Title: Speech codec employing speech classification for noise compensation
Inventor: BENYASSINE ADIL
IPC: G10L25/90
Filed: 1999-08-24
Granted: 2008-01-15
Abstract: A multi-rate speech codec supports a plurality of encoding bit rate modes by adaptively selecting encoding bit rate modes to match communication channel restrictions. In higher bit rate encoding modes, an accurate representation of speech through CELP (code excited linear prediction) and other associated modeling parameters are generated for higher quality decoding and reproduction. For each bit rate mode selected, pluralities of fixed or innovation subcodebooks are selected for use in generating innovation vectors.  The speech coder distinguishes various voice signals as a function of their voice content. For example, a Voice Activity Detection (VAD) algorithm selects an appropriate coding scheme depending on whether the speech signal comprises active or inactive speech. The encoder may consider varying characteristics of the speech signal including sharpness, a delay correlation, a zero-crossing rate, and a residual energy. In another embodiment of the present invention, code excited linear prediction is used for voice active signals whereas random excitation is used for voice inactive signals; the energy level and spectral content of the voice inactive signal may also be used for noise coding. The multi-rate speech codec may employ distributed detection and compensation processing the speech signal. For high quality perceptual speech reproduction, the speech codec may perform noise detection in both an encoder and decoder.  The noise detection may be coordinated between the encoder and decoder.  Similarly, noise compensation may be performed in a distributed manner among both the decoder and the encoder.
Patent CA-2342425-C (CA)
Title: Multiple tube bundle heat exchanger
Inventor: LANGL ALFRED
IPC: F28D7/00
Filed: 2001-03-28
Granted: 2005-05-17
Abstract: A multiple tube bundle heat exchanger includes axially opposite tube plates, a housing, and a plurality of tube bundles disposed between the tube plates. Each of the tube bundles is an independent tube bundle subassembly forming an integral unit having at least one heat exchanger tube with two axial tube ends. The subassembly is made from the exchanger tube and respective tube plates fastened to the two axial tube ends. The housing has a casing part defining a interior and having two axial housing end with flanges, removable head pieces respectively disposed at the too axial housing ends to be fastened to the flanges, and partitions subdividing the interior into chambers. The number of chambers corresponds to a number of tube bundles. Each of the chambers receives one of the tube bundles. The tube plates and head pieces respectively form seals, and the tube plates delimit distributor, collecting, and/or transfer chambers formed in the head pieces.
Patent CA-2344049-C (CA)
Inventor: BROWNING JEFF
IPC: A61K38/19
Filed: 1999-10-08
Granted: 2009-12-15
Abstract: This invention provides methods of inducing an antiviral response in an individual comprising administering to the individual an effective amount of a LT-B blocking agent and a pharmaceutically acceptable carrier. In particular this invention provides methods for treating viral-induced systemic shock and respiratory distress.
Patent CA-2349532-C (CA)
Inventor: TANAKA FUMIO
IPC: A61M5/24
Filed: 2000-09-06
Granted: 2005-11-01
Abstract: An electrically-driven dental injector used in orally injecting such an injection liquid as an anesthetic in dental treatment. Electrically-driven dental injectors includes one having a mechanism for disengaging a pinion (82) from a rack (48) in order to retract a plunger rod (44) upon completion of injectio n; however, it has heretofore been necessary to manually operate the operating part from outside each time. The inventive electrically-driven dental injector is so arranged that the plunger rod can be manually pushed back directly oupon completion of injection without reqiring manual operation, and, to this end, the injector comprises a latch mechanism (84) for engaging / disengaging the rin g gear (70) of a planetary reduction gear (50) with/from a casing (52), and an operating rod (94) extending through a support member (20) and functionally cooperatin g with the latch mechanism (84).
Patent CA-2356175-C (CA)
Title: Transdermal delivery of fine powders
Inventor: AVRAHAMI ZOHAR
IPC: A61M37/00
Filed: 1999-12-22
Granted: 2011-10-11
Abstract: A device for delivery of a powder (28) to the skin (60) of a subject includes a pad (20), made of an insulating material and having an upper side (22) and a lower side (24), which lower side is placed against the skin after application of the powder thereto. An electrical power source (30) applies an electrical potential to the pad, causing the powder to adhere by electrostatic force to the lower side of the pad, and then alters the potential so that the powder is released from the pad and contacts the skin against which the pad is placed.
Patent CA-2364837-C (CA)
Inventor: ZUMMO CONNIE J
IPC: A63D15/10
Filed: 2001-12-11
Granted: 2004-08-31
Abstract: A portable cue holder comprises a bag having a strap attached at one end. The bag is filled with a discrete material such as lead pellets. The relatively heavy lead pellets will allow the bag to conform to any substantially horizontal surface. The combination of the strap and the relatively heavy lead pellets functions to support the cue in a substantially vertical position.
Patent CA-2365466-C (CA)
Inventor: HODD KENNETH A
IPC: C08F4/00
Filed: 2000-03-16
Granted: 2011-01-11
Abstract: The invention relates to macromolecular photocrosslinkers having polymeric backbones of substituted ethylene or substituted siloxane groups carrying photoactive groups. The photocrosslinkers are capable of producing, when being exposed to light of determined wavelengths above 305 nm, radicals which are retained on the macromoleculecular photocrosslinkers and reacting so as to accomplish a crosslinked network structure. The invention further relates to the use of the photocrosslinkers in different systems and their utility in production of medical devices including ophthalmic lenses.
Patent CA-2368432-C (CA)
Inventor: ANDERSON DAVID J
IPC: H01R24/46
Filed: 2000-03-31
Granted: 2008-08-12
Abstract: A switching coax jack module and jack component provide for a removable DSX  jack which can be slid into and out of the front of a jack module housing without disconnecting other components of the jack module and without disconnecting the module from a chassis.  The jack includes a projecting post, and two rear ports. The post and rear ports cooperate with a rear interface unit including two projecting plugs, and a port for the post. The rear interface unit may include a switch activated by the post for disconnecting two of the rear connectors of the module when the jack is mounted to the module and engaged with the rear interface unit.
Patent CA-2369537-C (CA)
Inventor: LAMBERT ROBERT J
IPC: G06F17/10
Filed: 2002-01-29
Granted: 2013-07-23
Abstract: In general terms, the invention provides a finite field engine and methods for operating on elements in a finite field. The finite field engine provides finite field sub-engines suitable for any finite field size requiring a fixed number of machine words. The engine reuses these engines, along with some general purpose component or specific component providing modular reduction associated with the exact reduction (polynomial or prime) of a specific finite field. The engine has wordsized suitable code capable of adding, subtracting, multiplying, squaring, or inverting finite field elements, as long as the elements are representable in no more than the given number of words. The wordsized code produces unreduced values. Specific reduction is then applied to the unreduced value, as is suitable for the specific finite field. In this way, fast engines can be produced for many specific finite fields, without duplicating the bulk of the engine instructions (program).
Patent CA-2373698-C (CA)
Inventor: ZIMMERER PETER
IPC: G06F8/10
Filed: 2000-04-25
Granted: 2011-05-31
Abstract: A method is specified for comparing two specifications which each comprise at least two processes, each of which includes at least two events. A first comparison between the two specifications is carried out with regard to the sequence of the events in the processes, and a second comparison between the two specifications is carried out, taking account of the relationships between events in different processes.