baber/WOPTO huggingface dataset:
Patent RS-20050126-A (RS)
Title: Immunostimulatory nucleic acids
Inventor: KRIEG ARTHUR
IPC: C12Q1/68
Filed: 2003-08-19
Abstract: The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
Patent RS-20060053-A (RS)
Title: Substituted furochromenes, preparation thereof and their antiinflammatory action
Inventor: MERCEP MLADEN MAJSTORA RADONJE
IPC: C07D493/04
Filed: 2004-07-22
Abstract: The invention relates to novel compounds of formula (I) including all their tautomers to pharmaceutically acceptable salts and solvates thereof, to processes and reactive intermediates for the preparation thereof; to processes and reactive intermediates for the preparation of compounds of formula (II) including all their stereoisomers and tautomers to the use of the compounds of the formula (II) as suitable precursors for the preparation of the compounds of the formula (I) as well as to use of the compounds of the formula (I) and of the compounds of the formula (II) as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diesases and conditions in humans.
Patent AP-1219-A (AP)
Title: Novel modified MSP-1 nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems.
Inventor: CHEN LI HOW
IPC: A01K67/027
Filed: 1998-10-20
Granted: 2003-10-22
Abstract: The invention provides modified recombinant nucleic acid sequences (prefarably dna)and methods for increasing the mrna levels and protein expression of malarial surface protein msp-1 which is known to be difficult to express in cell culture systems, mammalian cell culture systems, or in trnasgenic animals. The preferred protein candidates for expression using the recombinant techniques of the invention are msp-1 proteins expressed from dna coding sequences comprising reduced overall at content or at rich regions and/or mrna instability motifs and/or rare codons relative to the native msp-1 gene.
Patent DO-P2006000039-A (DO)
Title: Estructura de lubricación para moldes de hacer cristalería
Inventor: CRAMER JEFFREY W
IPC: C03B40/027
Filed: 2006-02-14
Abstract: Un aparato para lubricar un molde en una sección individual de una maquina para hacer cristaleria a través de la combustion de al menos un gas combustible. El aparato incluye un eje (20) colocado adyacente al molde, una cabeza quemadora (24) sobre el eje y que incluye un electrodo chispeante (108) para encender un gas combustible que sale de la cabeza quemadora, un distribuidor (18) sobre el eje separado de la cabeza quemadora para conectar a una fuente de gas combustible, y una sección de gas (40) dentro del eje que se extiende desde el distribuidor a la cabeza quemadora.
Patent DO-P2007000055-A (DO)
Title: Composición farmaceutica que comprende un analgésico y vitaminas
Inventor: GARCIA SALGADO LOPEZ ENRIQUE RAUL
Filed: 2007-03-22
Abstract: La presente invención se refiere a las combinaciones farmacéuticas de sal de ketorolaco y complejo B; a métodos para la fabricación de dichas combinaciones; y particularmente, a las combinaciones sinérgicas de ketorolaco y complejo B útiles en el tratamiento de pacientes que sufren de dolor moderado a severo y neuralgias de diversa localización.
Patent DO-P2010000040-A (DO)
Title: Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol, su procedimiento de preparación, su aplicación como medicamentos, composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met
Inventor: BACQUE ERIC
IPC: C07D487/04
Filed: 2010-01-28
Abstract: La invención se refiere a los productos nuevos de fórmula (I): en la que representa un enlace sencillo o doble ; Ra representa H, Hal, alcoxi, O-cicloalquilo, heteroarilo, fenilo, NHCOalk, NHCOcicloalk o NR1R2; X representa S, SO o SO2; A representa NH o S; W representa H, alquilo o COR con R que representa cicloalquilo ; alquilo sustituido opcionalmente con NR3R4, alcoxi, hidroxi, fenilo, heteroarilo o hetrocicloalquilo ; alcoxi sustituido opcionalmente con NR3R4, es decir un radical O-(CH2)n-NR3R4, un radical O-fenilo o O-(CH2)n-fenilo, con fenilo sustituido opcionalmente y n= 1 a 4 ; o el radical NR1R2 ; R1 representa H o alk y R2 representa H, cicloalquilo o alquilo; R3 y R4 representan H, alk, cicloalquilo, heteroarilo o fenilo ; R1, R2 y/o R3,R4 forman con N un ciclo que contiene opcionalmente O, S, N y/o NH; estando todos los heterocicloalquilo, heteroarilo y fenilo y cíclicos sustituidos opcionalmente ; estando estos productos en todas las formas isómeras y las sales, como medicamentos principalmente como inhibidores de MET
Patent DO-P2010000329-A (DO)
Title: Inhibidores de la renina
Inventor: LACOMBE PATRICK
IPC: C07D417/14
Filed: 2010-11-03
Abstract: LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS INHIBIDORES DE RENINA BASADOS EN PERIDINILO 3,4-SUBSTITUIDOS TENIENDO EN 4-POSICIONES OXOPIRIDINA Y CON LA FÓRMULA (L). LA INVENCIÓN SE REFIERE ADEMÁS A COMPOSICIONES FARMACÉUTICAS CONTENTIVAS DE DICHOS COMPUESTOS, ASÍ COMO A SU USO EN EL TRATAMIENTO DE ACONTECIMIENTOS CARDIOVASCULARES E INSUFICIENCIA RENAL.
Patent DO-P2016000254-A (DO)
Title: Formulaciones farmeceuticas de inhibidor de la quinasa pan-raf, procedimientos para su preparacion, y metodos de uso.
Inventor: BOZON VIVIANA
IPC: C12Q1/68
Filed: 2016-09-23
Abstract: La invención se refiere a una composición farmacéutica que comprende el Compuesto 1 o una sal farmacéuticamente aceptable de este,para el tratamiento del cáncer y un proceso para su preparación. La invención también se refiere a la administración de la composición farmacéutica a un paciente de acuerdo con un régimen de dosificación intermitente.
Patent DO-P2016000329-A (DO)
Title: Extintor de incendio con mezcla interna y cartucho de gas
Inventor: RANDY ROUSSEAU
IPC: A62C13/74
Filed: 2016-12-20
Abstract: Se describen mejoras a un extintor de incendios portátil. Las mejoras permiten la inspección frecuente y simplificada y mantenimiento de un extintor de incendios con mínima capacitación y sin necesidad de equipo personalizado. Las mejoras incluyen un mecanismo anti-conexión que puede articularse a partir del exterior de la cámara para reblandecer, mezclar o agitar el polvo dentro de la cámara para mantenerlo en un estado licuado. Mejoras adicionales incluyen una abertura más grande para llenar más rápidamente e inspeccionar el polvo dentro de la cámara. Otra mejora incluye el uso de un cartucho de CO2 ubicado externo a la cámara para permitir un servicio más fácil o reemplazo de sólo el cartucho de CO2 así como capacidad de mantener la cámara en una condición no presurizada, permite que no se transporte por medio de HASMAT. Estas características prolongarán los intervalos de servicio mientras mantienen al extintor de incendios en una condición preparada.
Patent EC-SP10010368-A (EC)
Title: Derivados de urea de tetrahidroquinoxalina, su preparación
Inventor: NICOLAI ERIC
IPC: A61K31/495
Filed: 2010-07-23
Abstract: La invención se refiere a los compuestos que responden a la fórmula (I) en la que A representa un enlace, un átomo de oxígeno o un grupo -O-CH2- ; Ar1 representa un grupo fenilo o heteroarilo ; Ar2 representa un grupo fenilo, heteroarilo o heterocicloalquilo ; R1a,b,c y R2a,b,c representan un átomo de hidrógeno o de halógeno o un grupo alquilo, cicloalquilo, -alquil-cicloalquilo sustituido opcionalmente con uno o varios átomos de halógeno, -OR5 (hidroxi o alcoxi), hidroxi-alquilo, alcoxi alquilo, alcoxi-alcoxi, halógenoalquilo, -O-halógenoalquilo, oxo, -CO-alquilo, -CO-alquilo-NR6R7, CO halógenoalquilo, -COOR5, alquil COOR5, -O-alquil-COOR5, SO2-alquilo, SO2-cicloalquilo, SO2-alquil-cicloalquilo, SO2-alquilo-OR5, SO2-alquil-COOR5, SO2-alquil-NR6R7 SO2 halógenoalquilo, alquil-SO2-alquilo, -SO2-NR6R7, -SO2-alquil-O-alquil-OR5, CONR6R7, -alquil-CONR6R7 o O alquil NR6R7, o R1a, R 1b, R 1c están unidos respectivamente a R2a, R 2b, R 2c y al átomo de carbono al que están unidos y representan -O-alquil-O- ; R3 representa un átomo de hidrógeno o un grupo alquilo, R4 representa un átomo de hidrógeno o de halógeno o un grupo ciano, -OR5, hidroxi-alquilo, -COOR5, NR6R7, CONR6R7, SO2-alquilo o SO2-NR6R7, -NR6-COOR5, -NR6-COR5, -CO-NR6-alquil-OR5 ; R5, R6 y R7 representan un átomo de hidrógeno, un grupo alquilo o -alquil-fenilo, y R8 representa un átomo de hidrógeno, un grupo -SO2-alquilo o un grupo de fórmula -B-Het, en la que B puede estar ausente o representar un enlace, un átomo de oxígeno o un grupo -CO- o -SO2-(CH2)n con n igual a 0, 1 ó 2 y en la que Het representa un heteroarilo o un heterocicloalquilo sustituido opcionalmente con grupos alquilos, SO2-alquilos y -COOR5. Procedimiento de preparación y aplicación en terapéutica.
Patent EC-SP14013273-A (EC)
Title: Compuestos antibacterianos y métodos para su uso
Inventor: ZHANG XIAOYAN
IPC: C07D471/00
Filed: 2014-03-28
Abstract: La presente invención se relaciona con compuestos y formas y composiciones farmacéuticas de los mismos y métodos para el uso de los mismos para tratar o mejorar infecciones bacterianas causadas por patógenos Gram-negativos y Gram-positicos de tipo salvaje y resistente a varios tipos de drogas.
Patent GB-189404605-A (GB)
Title: Improvements in the Manufacture of Fabrics from Wood and like Fibre.
Inventor: PASS ERNEST DE
Filed: 1894-03-05
Granted: 1894-12-29
Abstract: 4605. Pass, E. de, [McLauchlin, J. C., and Hand, A. A.]. March 5. Artificial leather.-A fabric composed of wood or like fibre matted into sheets is softened and finished to resemble chamois by coating with a solution of gelatine or paraffin dissolved in gasoline, then crumpling the sheet laterally and passing it between rollers, the operator at the same time twisting the rope or sheet. The rolling operation is repeated, the twist being next time undone, and the sheet may then be passed through the rollers at right-angles to its former position.
Patent GB-189701956-A (GB)
Title: Improvements in Tyres for Velocipede and other Wheels.
Inventor: HOLTZE LUDWIG MARTIN WOLFGANG
Filed: 1897-01-25
Granted: 1898-01-01
Abstract: 1956. Holtze, L. M. W. Jan. 25. Braiding-machines. - Relates to elastic tyres mainly composed of interlaced helically -coiled spring steel wires, and to means employed for their manufacture. Fig. 7 shows a sectional elevation, and Fig. 8 a plan of a hand-plaiting frame which consists of sets of prismatic wood bars G and intermediate tooth racks H (shown separately in Fig. 9), bound together by the cap K and nut M and suspended so as to be incapable of swinging. The wire to be used is previously wound on to rings each of which is placed within a spool carrier c, Fig. 17, so as to be capable of freely revolving, and the loose end of one wire is connected to the loose end of another. The joined wire thus obtained is hooked over the top tooth of one of the tooth racks H, and the two spool-carriers are held in the hands of an attendant, the interlacing being obtained by interchanging the spool-carriers for others held in the same manner. When the full extent of the machine has been traversed, the coil is moved upwards by means of the mesh combs I and girdle P, the meshes of the coil being finally held at the proper distance apart by jointed link bars Q or similar link chains. In the machine shown in Figs. 17, 18, and 20, the interlacing is done by means of the shaped plate e and the stars a, adjoining stars being rotated in opposite directions. The coil is pushed onwards by the pivoted arms h, n, the positions of which are controlled by a vertically-movable tube 1 and a beam Z, Fig. 20, fitting into the tube. The arms q, r, s on this beam are arranged to allow of the meshes being held in their proper relative positions while the coil is being moved. The link bars Q are fed over rollers v and between guides u.
Patent GB-189704517-A (GB)
Title: Improvements in and connected with the Trimming Mechanism or Linotype Machines.
Filed: 1897-02-19
Granted: 1898-02-19
Abstract: 4517. Linotype Co. and Wich, F. J. Feb. 19. Linotype machines. - Relates to trimming-mechanism for use when linotypes having two-line letter capitals are to be cast, and is described as applied to the Mergenthaler machine (Specification No. 14,582, A.D. 1890). Fig. 2 shows a sectional plan through the knives and mould-wheel O. A linotype C having a two-line letter projection y<18> is shown in the mould o in position for ejection between the knives N<5>, N<6>. The knife N<6> is pivoted at N<50> and is shown in position for trimming ordinary linotypes, in which position it is held by stop bars N<66> bearing against adjusting-screws N<58> in the knife block P<1>. The stop bars N<56> are connected by links N<59> to a trigger lever N<51> pivoted at N<54>. The nose of the trigger is in the path of the projection y<18>, and is operated thereby to release the knife N<6> which is pulled away out of the path of the projection by a spring N<55>. The knife is returned to position by a bar N<65> which engages the plate N<49>. The bar N<65> is pivoted to arms N<63> operated by a rod N<62> connected to a pin n<28> on the mould-wheel slide. Springs N<60> return the stop bars to position to engage the knife. The knife N<6> may be made in sections, each having a trigger mechanism, so that one portion only is moved out of position corresponding to the position of the projection on the linotype. A sliding knife or sections of knives may be used instead of pivoted ones. Specifications No. 8258, A.D. 1894, and No. 1389, A.D. 1895, are referred to.
Patent GB-189704861-A (GB)
Title: Improvement in Valve-gears.
Inventor: GODDEN STEPHEN VERNER
Filed: 1897-02-23
Granted: 1897-06-05
Abstract: 4861. Godden, S. V. Feb. 23. Valve gear.-Fig. 1 shows the invention, which is a cam gear, applied to a locomotive. The valve spindle 17 is connected to a block which slides in a guide 1. The connection is made by a bolt 12 passing through a cam-slot in a plate 6 which is pivoted by a bolt 10 to a second block which also slides in the guide-framing 1. This block is reciprocated from a rocking shaft 15 by means of a rod 14, and the plate 6 is thereby rocked about a pin 7 in a block which is capable of vertical movement in an extension of the guide-frame.
Patent GB-189709582-A (GB)
Title: Improvements in Filter Presses.
Inventor: JOHNSON SAMUEL HENRY
Filed: 1897-04-15
Granted: 1897-07-17
Abstract: 9582. Johnson, S. H. April 15. Filter-presses.-Improvements are described on presses such as are described in Specifications Nos. 7045 and 14,415, A.D. 1886, in which the movable head or follower is actuated by hydraulic power. Fig 1<A> shows a sectional side elevation of an improved press, in which the sludge from the main passes through a cylinder I, and acts on a ram or piston by which pressure is maintained in the cylinder H and on the ram R of the press-bead E. A baffle b prevents ram action in the pipe supplying the filter. Water from a town's main or the like is supplied to the cylinder H, which can be emptied through a valve r to allow the weights W<1> to withdraw the press-head E. The ram R is actuated through the greater part of its stroke by this low-pressure supply of water, after which the valve SM is closed and the sludge-valve SV opened. When the sludge is very gritty, highpressure water may be used in the cylinder I in place of sludge. Various modifications in details may be made.
Patent GB-189715998-A (GB)
Title: Improvements in Closets.
Inventor: ADAMS MOSES JAMES
Filed: 1897-07-06
Granted: 1897-08-21
Abstract: 15,998. Adams, M. J. July 6. Flushing closets.-Waste or other water collects in a receptacle B in which is placed a cylinder J communicating with the scroll F, trap E, and drain C. When the piston K is raised by the handle M the contents of the cylinder are discharged through the basin as a flush. In a modification, the flush is delivered by a tipping- vessel.
Patent GB-189716485-A (GB)
Title: Machine for Opening or Unfelting Wool.
Inventor: HUBERT ACHILLE DE ST
Filed: 1897-07-12
Granted: 1898-06-11
Abstract: 16,485. St. Hubert, A. de. July 12. Openers.-Wool or other fibrous material is opened by apparatus such as that shown in Fig. 1. The material is fed from an endless band A between grooved rollers B. An oscillating comb C which is actuated and mounted so as to move in a path which is approximately elliptical, operates on the material as it leaves the rollers, the opened material falling on an endless band A' which carries it from the machine. Plates H, H<1> are arranged to prevent, by generating a current of air, the attachment of the fibres to the comb.
Patent GB-189725105-A (GB)
Title: Improvements in Lifting-jacks.
Inventor: HAYWOOD WILLIAM
Filed: 1897-10-29
Granted: 1898-04-23
Abstract: 25,105. Haywood W., and Warlow, W. R. Oct. 29. Lifting - jacks. -Fig. 3 shows a section of the head of the standard shown in Fig. 3. The lever G is pivoted in a stirrup F carried by a spindle C, the lower end of which bears upon an adjustable screw bearing b. The lifting-chain, Fig. 2, is attached to a point g on the lever.
Patent GB-189725720-A (GB)
Title: Improvements in Sounding Apparatus.
Inventor: WHITE JAMES DUNDAS
Filed: 1897-11-05
Granted: 1898-07-09
Abstract: 25,720. White, J. D. Nov. 5. Sounding-apparatus.-The sinker A is formed with a double flange or fin C, between which is pivoted at D a trigger X normally completing circuit at E, E<1> for a battery on board. When the trigger strikes the bottom, circuit is broken and a relay controlled by the main circuit rings a bell,
Patent GB-189800173-A (GB)
Title: Improvements in Machinery for Dressing Rhea Fibre, China Grass, Flax, Silk, and like Fibres.
Inventor: MELLOR ARTHUR
Filed: 1898-01-04
Granted: 1898-10-15
Abstract: 173. Mellor, A. Jan. 4. Heckling and silk-dressing machines.-In dressing silk, rhea, China grass, flax, and like fibre, the fibre, held in holders k on a frame j, is carried along the machine under combs and cords mounted on endless belts b, c, d, e and on a roller m. The frame j is traversed by screws i, or by rack and pinion gearing, and the feed and delivery ends of the machine are fitted with vertically-moving platforms, or with turntables, to facilitate the insertion and withdrawal of the frames. The belts, which are preferably driven in different directions, as indicated by arrows, are fitted with transverse bars of wood clothed with metallic teeth, those on the belts b, c being long teeth or combs, and those on the belts e, d being similar combs alternating with short teeth or cords. The rollers carrying the belts are adjustable so as to incline the belts, and to adapt them for belts of various lengths. Brushes u, v serve to press the noils or waste fibres towards the base of the combs, The roller m, which may be clothed with fine teeth or stiff bristles, serves to lay the fibre in a particular direction. By this arrangement, the fibres are operated upon in a graduated manner.
Patent GB-189800471-A (GB)
Title: Improvements in or relating to Canopies or Hoods for Motor Cars, Bath Chairs, Perambulators, and other Road Vehicles.
Inventor: DUNKLEY WILLIAM HENRY
Filed: 1898-01-07
Granted: 1898-11-12
Abstract: 471. Dunkley, W. H. Jan. 7. Hoods; invalid carriages; perambulators.-The bars A, F forming the toggle for raising and lowering the hood are pivoted together at E, and one of them has a retaining-pin I adapted to enter a slot J in the other. One of the bars may be furnished with a handle.
Patent GB-189808410-A (GB)
Title: Improvements in and connected with Steam Boilers.
Inventor: IVANOFF WASSILY
Filed: 1898-04-09
Granted: 1899-03-18
Abstract: 8410. Ivanoff, W. April 9. Steam - generator furnaces.-Relates to steam boilers in which the products of combustion are passed through the water in the boiler and then collected together with the steam produced. The furnace C is provided with an airtight fuel-feeding device E and supplied with compressed air by means of the pipe D. The products of combustion pass into the annular flue F, and are injected into the boiler through the valves G. The boiler may be lined with acidproof or fireproof material. Recesses are provided at the bottom of the boiler to collect ashes. If desired, the furnace may be separate from the boiler. The annular flue is connected to a chimney when the boiler is being started. Liquid or gaseous fuel may be used, and gaseous fuel may be burnt within the boiler itself.
Patent GB-189810436-A (GB)
Title: An Improved Explosion-engine or Motor.
Filed: 1898-05-06
Granted: 1899-05-06
Abstract: 10,436. Soc. Chauvin et Arnoux. Jan. 14, [date claimed under Sec. 103 of Patents &c. Act, A.D. 1883]. Drawings to Specification. Exhaust-silencers.-The exhaust from gas or oil engines is passed through the crank chamber to silence it.
Patent GB-189819003-A (GB)
Title: Improvements in Machines for the Manufacture of Woven Wire Fencing.
Inventor: COREY EDGAR ROBINSON
Filed: 1898-09-06
Granted: 1899-02-04
Abstract: 19,003. Lake, W. R., [Robinson, C. E.]. Sept. 6. Toothed gearing.-In a machine for making wire fencing, the wirefeed rolls are rotated intermittently by an interrupted gear 70. Accurate re - engagem e n t is assured by large teeth 70<a>, 70<b>, and the gear 69 is locked, when the teeth are not engaged, by a block 69<a> riding on a flange on the toothless part of the wheel 70.
Patent GB-189907811-A (GB)
Title: Improvements in Potato Planting Machines.
Inventor: ZAHL GUSTAV
Filed: 1899-04-13
Granted: 1899-07-29
Abstract: 7811. Zahl, G. April 13. Potato planters.-Consists of a feed-hopper f from which the seed potatoes are discharged intermittently down a shoot o into holes made in the ground by revolving spoon-shaped blades l secured on the main axle a of the carrying-wheels b, b. The feed-hopper f is formed with a circular depression in which a disc g operated from the axle a rotates. The disc g is formed with a number of holes h, which successively pass over the top of the shoot o to allow of the discharge of the potatoes from the hopper f. The discharge of the potatoes from the shoot o is timed by an annular disc m, which revolves with the blades l, and is provided with openings which uncover the mouth of the shoot o at the required moment.
Patent GB-189909703-A (GB)
Title: A New or Improved Way of Making Household Furniture or any other similar Goods with Tubes of Brass, Iron, Steel, or other Metals.
Inventor: ODDY JOHN
Filed: 1899-05-09
Granted: 1899-09-02
Abstract: 9703. Oddy, J. May 9. Furniture, general construction of; joints and connections.-Household furniture &c. is made from metal tubes a, b, c, d in a similar manner to that in which ordinary bamboo furniture is made. The rails c pass through holes e on one side only of the rails a, while the rails b pass completely through the rails a at e, e<1>. The various tubes are connected together by brazing, riveting, screwing, &c.
Patent GB-189910739-A (GB)
Title: Improvements in connection with Corsets.
Inventor: MERZ EMILIE
Filed: 1899-05-23
Granted: 1899-06-24
Abstract: 10,739. Merz, E. May 23. Corset.-Each half of the corset is provided on the outer side with a covering b, which is laced or otherwise detachably fastened to it and serves as a protector for it.
Patent GB-189911675-A (GB)
Title: An Improved Device for Automatically Opening and Closing a Sight Hole in connection with Apparatus for Exhibiting Animated Pictures.
Inventor: MALKE ERNST
Filed: 1899-06-05
Granted: 1899-08-05
Abstract: 11,675. Malke, E. June 5. Kinetoscopes.-Consists of a device for automatically opening a peep-hole during the exhibition of animated pictures. As the free ends of the leaves E' which bear the pictures sweep under and are successively released by the lever E, the latter, pivoted upon a support at F, is raised to the position shown in dotted lines. In so doing, the arm G, which is secured to the axis of the lever E and which presses against the arm C', is raised and the shutter removed from below the magnifying-glass A of the peep-hole B, the position taken up being that shown in dotted lines. When the passage of the leaves is completed, the lever E falls, and with it the shutter to close the peep-hole.