baber/WOPTO huggingface dataset:
Patent AU-631588-B2 (AU)
Title: Benzopyran derivatives and related compounds
IPC: C07D413/12
Filed: 1989-12-21
Granted: 1992-12-03
Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof: <CHEM>  wherein a and b together form an -O- linkage or a bond or (when R2 is hydrogen), CH2;  either Y is N and R2 is hydrogen; or  Y is C-R1  wherein either one of R1 and R2 is hydrogen and the other is nitro, cyano, halo, CF3, C2F5, formyl, aldoxime, CF3O, NO2-CH=CH-, NC-CH=CH-; a group RxX- wherein Rx is C1-6 alkyl, aryl or heteroaryl either of which may be optionally substituted by one, two or three of C1-4 alkyl, C1-4 alkoxy, nitro, halo, CF3 and cyano; and X is C=O, O.C=O C=O.O, CHOH, SO, SO2, O.SO, O.SO2, CONH, O.CONH, O.SO2NH, CO-CH=CH, C=NHOH, C=NNH2; or a group RyRzNZ- wherein Ry and Rz are independently hydrogen or C1-6 alkyl and Z is C=O, SO or SO2; or a group (RwO)2P(O)W wherein Rw is hydrogen or C1-6 alkyl and W is O or a bond; or R1 is a C3-8 cycloalkyl group or a C1-6 alkyl group optionally substituted by a group which is hydroxy, C1-6 alkoxy, amino optionally substituted by one or two C1-6 alkyl groups, C1-7 alkanoylamino, C3-8 cycloalkyloxy or C3-8 cycloalkylamino; and R2 is hydrogen; or one of R1 and R2 is nitro, cyano or C1-3 alkylcarbonyl and the other is a different group selected from nitro, cyano, halo, C1-3 alkylcarbonyl, methoxy or amino optionally substituted by one or two C1-6 alkyl or by C2-7 alkanoyl; or R1 and R2 together with the carbon atoms to which they are attached, form 2,1,3-oxadiazole; either one of R3 and R4 is hydrogen or C1-4 alkyl and the other is C1-4 alkyl; or R5 is hydrogen, hydroxy, amino, C1-6 alkoxy or C1-7 acyloxy; and  E is hydrogen; or  R5 and E together form a bond;  either R6 is hydrogen or C1-6 alkyl; and R7 is hydrogen, C3-8 cycloalkyl, C2-6 alkenyl, C1-6 alkyl optionally substituted by hydroxy, C1-6 alkoxy, C1-6 alkoxycarbonyl, carboxy, halogen or amino optionally substituted by one or two C1-6 alkyl groups; aryl or heteroaryl either being optionally substituted by one or more groups or atoms selected from the class of C1-6 alkyl, C1-6 alkoxy, hydroxy, halogen, trifluoromethyl, nitro, cyano, C1-12 carboxylic acyl, or R7 is amino or aminocarbonyl optionally substituted by one or two C1-6 alkyl groups or substituted by C3-8 cycloalkyl, or a group OR9 wherein R9 is C1-6 alkyl or benzyl optionally substituted as defined for R7; or R6 and R7 are joined together to form C3-4 polymethylene optionally substituted by one or two C1-6 alkyl groups and optionally containing one or, (when C4 polymethylene), two, C=C double bond(s); and  X is oxygen or sulphur; which are potassium channel activators, useful in the treatment of disorders associated with smooth muscle contraction, a process for their preparation and their use as pharmaceuticals.
Patent AU-621193-B2 (AU)
Title: Cyclic guanidines uses as calcium antagonists
Inventor: CARR ALBERT A
IPC: C07D239/84
Filed: 1990-02-09
Granted: 1992-03-05
Abstract: The present invention is directed to a new class of cyclic guanidines of the formula: <CHEM> in which Q is represented by a substituent selected from the group consisting of (CH2)n in which n is an integer from 2-10, <CHEM> A is a substituent selected from the group consisting of -NH-(CH2)m in which m is an integer from 0-5, a piperidino substituent, or a piperazino substituent; both Ar and Ar1 are each independently represented by a phenyl ring, each of which may be optionally substituted with up to 3 substituents, each selected from the group consisting of halogen, alkyl, alkoxy, hydroxy, and trifluoromethyl; and R is represented by either hydrogen or an alkyl; R1 is represented by hydrogen or an alkyl; the tautomers, and optical isomers thereof; and the pharmaceutically acceptable acid addition salts thereof; with the provisos that: 1) when Q is represented by (CH2)2,3,or 4 , then A is not represented by NH-(CH2)o; and 2) when Q is represented by (CH2)2 and R is an alkyl; then A is not NH-(CH2), and to their use as calcium antagonists.
Patent AU-570138-B2 (AU)
Title: Composite spring
Inventor: STEVENSON ANDREW
IPC: B60G11/52
Filed: 1985-11-18
Granted: 1988-03-03
Abstract: The spring includes a tubular elastomeric body, preferably rubber, and a coil spring embedded in and bonded to it. The coil spring controls the occurrence of symmetric bulging instability in the body under axial load conditions. This bulging instability occurs sequentially along the length of the body between adjacent coils of the coil spring until it assumes the form of a continuous coil of elastomer.
Patent AU-672827-B2 (AU)
Title: Conveyor mat built up of synthetic modules and modules for such conveyor mat
Inventor: BOS ARNOLDUS JOSEPHUS LEONARDU
IPC: B65G15/32
Filed: 1993-11-16
Granted: 1996-10-17
Abstract: A conveyor mat built up of first (10) and second (20) modules, made in one piece of synthetic material, the width of the first modules being substantially twice the width of the second modules, with the modules, viewed in the longitudinal direction of the mat, being staggered, each module consisting of a plurality of substantially equally spaced-apart hinge plates (12,22), each extending over substantially the entire length of the module and each having hinge loops (13'13'';23',23'') at the two ends thereof, the hinge plates of a module being coupled by means of at least one rib disposed between the two ends, the ends of the hinge plates being disposed at a longitudinal side of a module between the ends of the hinge plates of an adjacent module in the longitudinal direction of the mat, the hinge loops of the two modules being substantially in alignment and coupled to each other by means of a hinge pin extending through the hinge loops, there being provided means for locking the hinge pin relatively to the modules, characterized in that the second modules (20) are located exclusively on the two lateral sides of the conveyor mat, a first module (10) always being disposed between two consecutive second modules (20) at one lateral side, that of each second module, the end hinge plate disposed at the lateral side of the mat comprises the means for locking the two hinge pins that couple said second module to both first modules adjoining in the longitudinal direction of the mat, and that the first and second modules have such a width that at the lateral sides of the mat, the end faces of the first modules and second modules are substantially in line. <IMAGE>
Patent AU-588847-B2 (AU)
Title: Power control arrangement
Inventor: GRASSO ALFIE LUCRETIUS
IPC: H05B1/02
Filed: 1985-12-12
Granted: 1989-09-28
Abstract: A power control arrangement for controlling the power output of a plurality of resistive heating elements (9a, 9b) comprises a multi-position switch (S1, S2) for connecting the heating elements in series and in parallel and means (4, 5, 6, 7, 8) for varying the duty cycle applied to the heating elements in both serial and parallel modes.
Patent AU-667988-B2 (AU)
Title: Device for a burner preferably for a spirit stove
Inventor: ARVIDSSON THOMAS
IPC: F24C5/02
Filed: 1993-12-21
Granted: 1996-04-18
Abstract: This invention relates to a device for a burner for a spirit stove operating without pressure. The stove comprises a fuel container (10) with a mass absorbing the spirit, and the container (10) has an opening (11) in which the absorbing mass is uncovered in order to form an evaporation surface for the spirit. The stove has also a flame spreader (15) which is placed above the opening (11) and which comprises a mainly horizontal plate (16) with a downwardly extending edge part (17) at which air during burning flows to the evaporation surface. The plate (16) has several openings (22) which are so shaped that several minor flames are created having a horizontal and a tangential direction component. <IMAGE>
Patent AU-580380-B2 (AU)
Title: Deactivation of catalyst in solution process for polymerization of alpha-olefins
Inventor: ZBORIL VACLAV GEORGE
IPC: C08F2/42
Filed: 1986-01-28
Granted: 1989-01-12
Abstract: A solution polymerization process for the pre-paration of high molecular weight homopolymers of ethylene and copolymers of ethylene and C3 - C12 alpha-olefins comprises feeding monomer(s), coordination catalyst and inert hydrocarbon solvent to a reactor, polymerizing the monomers at a temperature of up to 320 DEG C and a pressure of less than 25 MPa, and deactivating the catalyst in the solution so obtained. The catlyst is deactivated by sequentially admixing therewith (a) a minor amount of a first deactivator, (b) a solution of a salt of an alkaline earth metal or zinc and an aliphatic mono-carboxylic acid dissolved in hydrocarbon solvent, and (c) an organosilicon compound. The solution of (b) and the compound of (c) may be combined. The first deactivator may be water, a nitrogenous base or carbon dioxide or the like. The organosilicon compound is of the formula SiR min n (OR) sec )4-n where R min  and R sec  are alkyl or cycloalkyl and n is 0-3. The hydrocarbon solvent and other volatile matter are then separated from the resultant solution and a composition comprising said high molecular weight polymer is recovered.
Patent AU-649223-B2 (AU)
Title: Apparatus and method for calibrating a sensor system
Inventor: LANGE ANTTI AARNE ILMARI
IPC: G01D3/02
Filed: 1990-04-27
Granted: 1994-05-19
Abstract: A method and apparatus for calibrating a sensor system output that includes a logic unit (1) for receiving uncalibrated sensor signals from a centralized sensor system (3) and for reading/writing data from/to a data base unit (2) that contains updated information on all control (4) and performance aspects of the sensors. Based upon these inputs, the logic unit (1) can provide real-time or near real-time optimum calibration (5) of the sensors by using the Fast Kalman Filtering (FKF) method when the stability conditions of standard Kalman Filtering are met by the sensor system.
Patent AU-691164-B2 (AU)
Title: Method of treatment of chronic prostatitis with 17beta -N-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-E N-3-ones
Inventor: GORMLEY GLENN J
IPC: A61K31/58
Filed: 1993-11-18
Granted: 1998-05-14
Abstract: PCT No. PCT/US93/11155 Sec. 371 Date Jun. 2, 1995 Sec. 102(e) Date Jun. 2, 1995 PCT Filed Nov. 18, 1993 PCT Pub. No. WO94/14452 PCT Pub. Date Jul. 7, 1994The present invention is concerned with the use of 17 beta -N-monosubstituted-carbamaoyl-4-aza-5 alpha -androst-1-en-3-one compounds as testosterone-5 alpha -reductase inhibitors for the treatment of chronic prostatitis.
Patent AU-671701-B2 (AU)
Title: Method of and apparatus for processing, sterilising and packaging food
Inventor: STEVENS ALAN
IPC: A23L1/00
Filed: 1993-12-13
Granted: 1996-09-05
Abstract: Method of and apparatus for processing, sterilizing and packaging solid food in which a food portion is held in a saline solution contained in an enclosure formed by a packaging film, the food portion is processed and sterilized by ohmic heating, which also sterilizes the inside surface of the film, and after processing, the enclosure is collapsed around the food portion and resealed as an encapsulation around it, thus producing a sterilized package.
Patent AU-734625-B2 (AU)
Title: Method for preparing a fibrin sealant
Inventor: PATAT JEAN-LOUIS
IPC: A61L24/00
Filed: 1997-12-30
Granted: 2001-06-21
Abstract: A biological adhesive which, in aqueous solution does not spontaneously coagulate within an hour at 20 degrees C but which coagulates within 5 minutes following addition of calcium ions, is prepared by: (a) obtaining blood plasma; (b) obtaining a fibrinogen and coagulation factor-based biological adhesive from the plasma by known methods; and (c) optionally submitting the biological adhesive to lyophilisation. The plasma is contacted with a contact phase activator before or during (b). An apparatus for carrying out this process is also claimed, comprising a first container for receiving the plasma, before or during activation, a second container for receiving the plasma after activation, means for sterile transfer of plasma, means for contacting the plasma with the activator, and means for separating them.
Patent AU-623790-B2 (AU)
Title: Cosmetic composition
Inventor: PERIERA MAVIS CLAIRE
IPC: A61K8/06
Filed: 1990-06-27
Granted: 1992-05-21
Abstract: A water-in-silicone oil transparent emulsion is made from a volatile polydimethylsiloxane (1 to 50% by weight), a silicone surfactant (0.1 to 20% by weight), at least one polyhydric alcohol (1 to 50% by weight) and water. The silicone surfactant comprises a polymer of dimethyl polysiloxane with polyoxyethylene and/or polyoxypropylene side chains having a molecular weight of from 10,000 to 50,000 and having the structure: <CHEM>  a having a value of from 9 to 115,  b having a value of from 0 to 50,  x having a value of from 133 to 673, y having a value of from 25 to 0.25.
Patent AU-742405-B2 (AU)
Title: Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
Inventor: NGUYEN THAI D
IPC: C12Q1/68
Filed: 1998-01-09
Granted: 2002-01-03
Abstract: The nucleic acid upstream of the TIGR protein encoding sequence can be used to diagnose glaucoma. Polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to diagnose glaucoma. In addition, polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to prognose glaucoma.
Patent AU-683439-B2 (AU)
Title: Method and apparatus for sunless tanning
Inventor: MEYER THOMAS A
IPC: A61K8/898
Filed: 1993-12-14
Granted: 1997-11-13
Abstract: PCT No. PCT/US93/11906 Sec. 371 Date Jun. 6, 1995 Sec. 102(e) Date Jun. 6, 1995 PCT Filed Dec. 14, 1993 PCT Pub. No. WO94/13258 PCT Pub. Date Jun. 23, 1994Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising a secondary polyamine, and dispensing means for simultaneously or sequentially providing desired amounts of dihydroxyacetone and polyamine.
Patent AU-616358-B2 (AU)
Title: Process for the removal of cholesterol or cholesterol esters from egg yolk
Inventor: CULLY JAN
IPC: A23L5/20
Filed: 1990-08-08
Granted: 1991-10-24
Abstract: Cholesterol and cholesterol esters are removed from egg yolk by a process wherein a) optionally after the addition of an emulsion-breaking agent to the egg yolk, the egg yolk plasma is separated from the LDL-granula fraction, b) cholesterol and cholesterol esters which are contained in the egg yolk plasma are adsorbed on a solid adsorption agent and c) the solid material loaded with cholesterol and/or cholesterol esters is separated from the liquid plasma phase and optionally the egg yolk plasma and the separated granula fraction are again mixed together.
Patent AU-685776-B2 (AU)
Title: Ganglioside-KLH conjugate vaccines with QS-21
Inventor: LIVINGSTON PHILIP O
IPC: A61K45/08
Filed: 1994-01-21
Granted: 1998-01-29
Abstract: This invention provides a vaccine for stimulating or enhancing the production of an antibody which recognizes a ganglioside in a subject to which the vaccine is administered. The vaccine is comprised of an amount of ganglioside or oligosaccharide portion thereof conjugated to an immunogenic protein effective to stimulate or enhance antibody production in the subject. The vaccine is further comprised of an adjuvant and a pharmaceutically acceptable vehicle. The invention also provides a method of using the vaccine for treating or preventing cancer wherein gangliosides are on the surface or in the stroma of the cancer cells.This invention provides a vaccine for stimulating or enhancing the production of an antibody which recognizes a ganglioside in a subject to which the vaccine is administered. The vaccine is comprised of an amount of ganglioside or oligosaccharide portion thereof conjugated to an immunogenic protein effective to stimulate or enhance antibody production in the subject. The vaccine is further comprised of an adjuvant and a pharmaceutically acceptable vehicle. The invention also provides a method of using the vaccine for treating or preventing cancer wherein gangliosides are on the surface or in the stroma of the cancer cells.
Patent AU-763628-B2 (AU)
Title: Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug
Inventor: GRIFFITHS GARY L
IPC: A61K47/48
Filed: 1999-09-17
Granted: 2003-07-31
Abstract: A method for increasing the target-specific toxicity of a drug is effected by pretargeting an enzyme to a mammalian target site, and then administering a cytotoxic drug known to act at the target site, or a prodrug form thereof which is converted to the drug in situ, which drug is also detoxified to form an intermediate of lower toxicity using said mammal's ordinary metabolic processes, whereby the detoxified intermediate is reconverted to its more toxic form by the pretargeted enzyme and thus has enhanced cytotoxicity at the target site. Further enhancement can be achieved by pretargeting an enzyme which converts the prodrug to the cytotoxic drug at the target site. Kits for use with the method also are provided. The method and kits permit lower doses of cytotoxic agents, maximize target site activity and minimize systemic side effects.
Patent AU-585655-B2 (AU)
Title: A hotmelt mixture
Inventor: LEONI ROBERTO
IPC: C09J5/06
Filed: 1986-10-03
Granted: 1989-06-22
Abstract: Thermoplastic polyamide mixtures of polyamides based on dimerized fatty acids in which at least one polyamide contains as an incorporated unit (a) a C2-C10 aliphatic diamine capable of diamide formation, which is N-substituted with C10-C25-alkyl, and (b) a C2-C40-diamine capable of diamide formation comprising a diprimary amine, a heterocyclic amine, or a diomine containing one or two secondary amino groups and which is N-C1-C8-alkyl-substituted on at least one side.
Patent AU-766084-B2 (AU)
Title: Modulation of gene expression by combination therapy
Inventor: BESTERMAN JEFFREY M
IPC: C12N5/10
Filed: 1999-10-19
Granted: 2003-10-09
Abstract: The invention relates to the modulation of gene expression. In particular, the invention relates to compositions comprising antisense oligonucleotides which inhibit expression of a gene in operable association with protein effectors of a product of that gene, and methods of using the same. In addition, the invention relates to the modulation of mammalian gene expression regulated by methylation.
Patent AU-769172-B2 (AU)
Title: High temperature resistant saline soluble fibres
Inventor: JUBB GARY ANTHONY
IPC: D01F9/08
Filed: 2000-08-24
Granted: 2004-01-15
Abstract: A fibre is disclosed having a maximum use temperature of 1200° C. or more which comprises: SiO2>64.25 wt % CaO>18 wt % MgO<17 wt % and in which the amount of MgO in mol % is greater than the amount of CaO in mol %. Such fibers have high solubility and low dustiness.
Patent AU-736550-B2 (AU)
Title: Antipicornaviral compounds, compositions containing them, and methods for their use
Inventor: DRAGOVICH PETER S
IPC: C07C271/22
Filed: 1998-03-26
Granted: 2001-08-02
Abstract: Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds of formula (I), wherein M is O or S, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.
Patent AU-686170-B2 (AU)
Title: Preparation of symmetrical or unsymmetrical disubstituted N-cyanodithioiminocarbonates
Inventor: MARBLE LYNDON K
IPC: C07C333/20
Filed: 1994-05-18
Granted: 1998-02-05
Abstract: A process which involves the step of contacting, in a methanolic solvent system, a metal salt, preferably a Group 1 or 2 metal salt, of the anion of formula II    <IMAGE>  II  with at least one compound containing an R-group under conditions sufficient to form a symmetrical or unsymmetrical compound of formula I    <IMAGE>  I  where the R-group is any suitable substituent group.
Patent AU-643738-B2 (AU)
Title: Process for the preparation of salt free, water free 3-isothiazolone compounds
Inventor: PETIGARA RAMESH BALUBHAI
IPC: C07D275/03
Filed: 1991-01-10
Granted: 1993-11-25
Abstract: A process is disclosed for preparing a 3-isothiazolone of the formula   <CHEM>  wherein Y is selected from the group consisting of alkyl or substituted alkyl of 1 to 10 carbon atoms; unsubstituted or halogen-substituted alkenyl or alkynyl of 2 to 10 carbon atoms; and aralkyl or halogen-, lower alkyl-, or lower alkoxy-substituted aralkyl of up to 10 carbon atoms;   X is hydrogen or a (C1-C2) alkyl; and X<1> is hydrogen, chlorine, or a (C1-C2) alkyl; comprising (a) reacting anhydrous ammonia with an isothiazolone salt of the formula <CHEM>  wherein Z is chlorine, bromine, sulfate or fluorosulfonate; m is 1 when Z is chlorine, bromine or fluorosulfonate, and m is 2 when Z is sulfate; and (b) separating the resultant (NH4)mZ from the resultant free base isothiazolone. Preferably the isothiazolone salt is dissolved or suspended in an organic solvent in which the free base isothiazolone is essentially soluble and the (NH4)mZ salt essentially insoluble.
Patent AU-642483-B2 (AU)
Title: Rice dextrin oral rehydration solution
Inventor: TAO MICHAEL C
IPC: A23L7/10
Filed: 1991-04-02
Granted: 1993-10-21
Abstract: An improved oral rehydration solution comprising a mixture of rice dextrin and required electrolytes is provided. The functionality of the rice dextrin in oral rehydration solutions is superior to glucose in infants with chronic diarrhea resulting in lower stool output and enhanced water retention. Rice dextrin also has a polymer profile which provides more readily available glucose than corn dextrin or rice flour. There is also provided a process for clarifying solutions of rice dextrin which involves a first filtration at 35 DEG C to 50 DEG C and a second filtration at temperatures above 80 DEG C using filter aid and activated carbon.
Patent AU-699816-B2 (AU)
Title: Laser marking system for gemstones and method of authenticating marking
Inventor: KAPLAN GEORGE R
IPC: B23K26/04
Filed: 1996-11-14
Granted: 1998-12-17
Abstract: A laser microinscribing system includes a Q-switched Nd: YLF laser (1) with a harmonic converter producing an output of about 530 mm, an optical system including a focussing lens, a gemstone mounting holder (144) that is displaceable along three axes for moving a workpiece (11) such as a gemstone with respect to the optical system so that laser energy is presented to desired positions, an imaging system for viewing the gemstone from a plurality of viewpoints including a top CCD (28) and a side CCD (32), a processor controlling the position of the holder (144) based on marking instructions and a predetermined program, and a storage system (156) for storing information relating to images of a plurality of workpieces. A rigid frame supports the laser (1), the optical system and the holder (144) to increase immunity to vibrational misalignments. A secure certificate of authenticity of a market workpiece (11) is preferably provided having an image of the marking as well as the outline of a girdle of the gemstone.