baber/WOPTO huggingface dataset:
Patent JP-2003145543-A (JP)
Title: Parting lock device
Inventor: HIRAI YOSHIHIRO
IPC: B29C33/20
Filed: 2001-11-14
Abstract: PROBLEM TO BE SOLVED: To easily manufacture a mold without forming fitting holes for a parting lock tool. SOLUTION: This parting lock device is equipped with a first and a second blocks 2 and 3 and a parting lock tool 5 which connects the first and the second blocks 2 and 3 together with an optional strength. In addition, the device is used in such a manner that each of the first and the second blocks 2 and 3 is fitted to the side face of each of a pair of molds 60 and 61.
Patent JP-2003183534-A (JP)
Title: Method for producing charge-generating material and photosensitive product for electronic photography
Inventor: UCHIDA TADAYOSHI
IPC: G03G5/07
Filed: 2001-12-20
Abstract: <P>PROBLEM TO BE SOLVED: To provide a method for producing a charge-generating material at a low cost for use in a photosensitive product with high sensitivity.  <P>SOLUTION: Ortho-phthalodinitrile reacts with a titanium alkoxide represented by formula (1) at a temperature of 100°C or more in the presence of an O-alkylisourea derivative for a catalyst in the solvent of a monovalent alcohol containing at least one ether bond to obtain a charge-generating material containing mainly oxytitanium phthalocyanine. The solvent used in the present invention is environment-friendly, unlike a conventional solvent having a high boiling point. The O-alkylisourea derivative, which is more reactive and is added at a less amount than the other catalysts, is not left as an impurity in the charge-generating material, and thus can be used for a photosensitive product to give the charge-generating material with high sensitivity.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2002279000-A (JP)
Title: Color-designating server, color-designating order- receiving/ordering system, color-designating method, color-designating order-receiving/ordering method and recording medium therefor
Inventor: UCHIUMI HIDEKI
IPC: G06Q30/06
Filed: 2001-12-20
Abstract: PROBLEM TO BE SOLVED: To provide a color designating server displaying a picture for designating a color on a user terminal which can be connected to a network and supplying information of the color which can be realized to a user, and to provide a color-designating order-receiving/ordering system, a color designating method, a color-designating order- receiving/ordering method and a recording medium therefor. SOLUTION: In the color designating server 11 displaying a picture for designating a color to the user terminal, a matchable color information database 102a stores information required for obtaining the matchable color. A condition designation processing part 104 transmits a condition designating picture urging the designation of condition information required for obtaining the matchable color to the user terminal. A color information transmission processing part 105 obtains the matchable color based on condition information designated by the condition designating picture within the range of a condition specified by the designated condition information by referring to the matchable color information database 102a and transmits the result to the user terminal.
Patent JP-2003183551-A (JP)
Title: White ink composition for inkjet
Inventor: KONDO AI
IPC: C09D11/38
Filed: 2001-12-21
Abstract: <P>PROBLEM TO BE SOLVED: To provide a white ink composition for inkjet, having good visibility even to a transparent recording medium without ink absorptivity, to a medium having low lightness and a metal surface of, and showing an excellent printing property in image quality, a drying property, adhesion to a base material and durability.  <P>SOLUTION: The white ink composition for the inkjet is composed of at least a white pigment, a polymerizable compound and a photopolymerization initiator, wherein viscosity thereof at 30°C is 10-500 mPa.s.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003183311-A (JP)
Title: Manufacturing method of vinyl polymer
Inventor: SAITO RYUICHI
IPC: C08F2/40
Filed: 2001-12-21
Abstract: <P>PROBLEM TO BE SOLVED: To provide a manufacturing method of vinyl polymers, in which a retarding agent can be added in a polymerization system without using an organic solvent even under cold circumstances and clotting of the retarding agent in a charging tank or a pipe arrangement and blocking in the pipe arrangement thereby can be prevented.  <P>SOLUTION: The manufacturing method of vinyl polymers is characterized by comprising a stage to polymerize a vinyl monomer in an aqueous solvent in a polymerization vessel by a radical reaction and a stage to charge the retarding agent having a melting point of 40°C or lower into the polymerization vessel from a charging tank for the retarding agent via the piping arrangement for charging the retarding agent, wherein the retarding agent is added in the polymerization vessel under the condition that the retarding agent is kept to be a liquid having a viscosity of 200 mPa.s or less by keeping the charging tank for the retardant agent and the piping arrangement for charging the warm retardant agent.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003193105-A (JP)
Title: Powder compacting process
Inventor: UEDA KATSUHIKO
IPC: B22F3/02
Filed: 2001-12-25
Abstract: <P>PROBLEM TO BE SOLVED: To provide an index to judgment, in a powder compacting process for metal powder, as to whether the metal powder is applicable to a warm die lubrication process and whether a large effect can be produced even in the case of compaction where a lubricant is added and hereby to inexpensively produce a high-density green compact.  <P>SOLUTION: In the powder compacting process where raw-material powder in a die cavity is pressed to form the green compact, the work hardening exponent n-value of pure-metal powder or alloy powder of highest content in the raw-material powder is used as an index, and the raw-material powder having ≥0.3 n-value is heated and pressed and the raw-material powder having <0.3 n-value is pressed at ordinary temperature.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003182364-A (JP)
Title: Vehicle sun visor
Inventor: TANAKA MASANORI
IPC: B60J3/02
Filed: 2001-12-25
Abstract: <P>PROBLEM TO BE SOLVED: To provide a vehicle sun visor with superior recyclability, of which the sun visor body has excellent moldability.  <P>SOLUTION: The vehicle sun visor 1 comprises the sun visor body 2, and a holder 3 for fitting the sun visor body 2 on the vehicle body in a swingable manner. The sun visor body comprises a synthetic resin molded body 21, and a fitting shaft 22 integrally molded with the synthetic resin molded body 21 and inserted and fitted into the holder 3. The holder 3 comprises a fixing part 31 fixed to the vehicle body, an insertion hole 32 into which the fitting shaft 22 is inserted, and a metal spring 33 for holding the fitting shaft 22 in the insertion hole 32 in a swingable manner.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003191374-A (JP)
Title: High-color laminated metallic strip having double-layer resin coating film and hardly susceptible of color deterioration during working
Inventor: CHIJIKI TOORU
IPC: B32B15/08
Filed: 2001-12-26
Abstract: <P>PROBLEM TO BE SOLVED: To provide a high-color laminated metallic strip almost free from a deterioration in color during working which is a laminated metallic strip hardly susceptible of color deterioration especially during die, stretch or overhang working and applicable for a main use as a can material and further, has a double-layer resin coating film in the high-color laminated metallic strip almost free from color deterioration during working.  <P>SOLUTION: This high-color laminated metallic strip has a ground resin coating film formed on the face of the metallic strip and a white or colored intermediate resin coating film which shows a different refractive index from the ground resin coating film and contains a white or colored pigment formed on the ground resin coating film. In addition, the strip has a double-layer resin coating film with a resin film formed on the intermediate resin coating film and is hardly susceptible of color deterioration during working. Besides, the ground resin coating film is desirably 5 μm or thinner, and a white or colored resin coating film is desirably applied between the metallic strip and the ground resin coating film as a useful construction for securing a high color effect.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2002282639-A (JP)
Title: Process and device for eliminating volatile elements, in particular chlorides and/or sulfates, contained in stream of fumes
Inventor: JORGET SERGE
IPC: B01D46/00
Filed: 2001-12-26
Abstract: PROBLEM TO BE SOLVED: To provide a process and device for eliminating harmful volatile elements, in particular chlorides and/or sulfates contained in a stream of particle-laden fumes. SOLUTION: A given fraction (1) of at least 5% of the fumes, referred to as by-passed fumes, is extracted and the harmful elements of the by-passed fumes are caused to condense (4) at least with regard to their particles, according to a distribution that is a function of the fraction extracted and the particles are filtered (8, 12) to isolate the harmful elements.
Patent JP-2002230240-A (JP)
Title: Method and apparatus for constructing and operating cyber-conference in virtual space
Inventor: RHEE JAE SEONG
IPC: G06Q50/00
Filed: 2001-12-27
Abstract: PROBLEM TO BE SOLVED: To provide a method and an apparatus for constructing and effectively operating a cyber-conference in a virtual space in which a large volume of information is exchanged and shared through communication networks such as the Internet. SOLUTION: Conference clients 120 connect with a cyber-conference operation site installed by a cyber-conference operation server 142, make an application for a cyber-conference operation to the cyber-conference operation server 142 and, according to the application from the conference clients 120, the cyber- conference operation server 142 approves the cyber-conference operation based on the data stored in a data base 146. Based on the predetermined cyber- conference generating program stored in a program storage part 144 through a communication network 130 under the control of the cyber-conference operation server 142, the conference clients 120 generate the cyber-conference in the virtual space, the conference clients 120 hold the academic meeting of the cyber-conference, and the conference clients 120 process the data related to the academic meeting.
Patent JP-2003197593-A (JP)
Title: Substrate processing method and apparatus
Inventor: NODA SEIJI
IPC: B08B3/08
Filed: 2001-12-27
Abstract: <P>PROBLEM TO BE SOLVED: To provide a substrate processing method and apparatus which can stably process a substrate for a long period of time by preventing corrosion of the wiring metal resulting from acidic substances and moistened ozone gas and by reducing amount of use of high purity acetic acid.  <P>SOLUTION: In the substrate processing method organic substances at the surface of substrate are removed with the gas including ozone moistened by the processing solution. As the processing solution, a mixed solution of acetic acid and water may be used. Accordingly, because of use of the mixed solution of acetic acid and water and no use of a high concentration chemical solution the substrate can be processed while corrosion of wiring metal is suppressed.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003196266-A (JP)
Title: Font providing method, font providing server, font providing program and recording medium
Inventor: KUBO HIROSHI
IPC: G06F13/00
Filed: 2001-12-28
Abstract: <P>PROBLEM TO BE SOLVED: To provide a font providing method, a font providing server, a font providing program, and a recording medium capable of reducing the load of the system of a client or a server, and making it unnecessary to consider the difference of the character codes of the client and the server or to use any image file.  <P>SOLUTION: This font providing method for making a server 10 provide fonts to a client 14 comprises a step for making fonts into text data and a step for transmitting the fonts made into the text data to the client.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003527741-A (JP)
Title: 波長選択可能なファイバレーザ・システム
IPC: H04B10/294
Filed: 2000-04-24
Abstract: (57)【要約】
ポンプ波長の放射光によって光学的にポンピングされる際に、異なる波長のそれぞれで出射するように組み立てられた多重ファイバレーザを含むファイバレーザ・システム（10）である。ポンプレーザ（30）はポンプ放射を出射し、１つ以上のファイバレーザ（12、38）をポンピングする。ファイバレーザの出力は伝送ファイバ上へ再結合され、好ましくは波長分割多重（ＷＤＭ）（60）通信システムにおいて使用される。実施例の１組において、光スイッチはポンプ放射をファイバレーザ（12、38）のうちの１つのみに切り替える（32、41）。第１スイッチ（32）に応じて制御される第２スイッチ（41）、若しくは、受動結合器、好ましくは、波長分割マルチプレクサ（60）は、レイジングファイバの出力を光出力経路へと向ける。別の実施例において、１つのポンプレーザ（30）は、同時に全てのファイバレーザをポンピングする。１つ以上のポンプレーザが並列に配置されて、それらの出力が結合される。該並列配置されたポンプレーザ（30）は、冗長性のために個々に活性化されるか、若しくは、より高いパワーのために同時に動作されるかのいずれかである。
Patent JP-2003521104-A (JP)
Title: サブストレートに構成素子を装着するための方法
IPC: H05K13/04
Filed: 2000-05-17
Abstract: (57)【要約】
サブストレート上に装着すべき構成素子が、１つのラインに配置された複数の処理領域（６，１１）に分割される場合、装着物が少ないと、サブストレート（１）上におけるマーキングの付加的な測定により、及び、装着ヘッド（４）の保持装置（５）の数量により、好ましくないダウンタイムが生ずる。本発明によると、装着物が少ない場合、全ての装着物は１つの処理領域（６）内で装着される。したがって、複数の搬送装置（７，１２）を用いる場合、相互に依存せずに作動する複数の装着ラインが形成される。
Patent JP-2003504969-A (JP)
Title: 可視指示器装置を有する携帯通信装置と可視状態表示を与える方法
IPC: H04W88/02
Filed: 2000-06-22
Abstract: (57)【要約】
移動通信網で使用する携帯通信装置（１）は移動通信網への第１無線通信リンクを提供する送受信装置（２７）を有する。これはまた第１無線通信リンクの状態を指示するため、第１の所定のスペクトル範囲内で、第１可視光信号を発光するようにされた可視指示器装置（２２）も有する。送受信装置はまた移動通信網以外の機器への第２無線通信リンクも提供する。可視指示器装置（２２）は第２無線通信リンクの状態を指示するための第２可視信号を発光し、ここでこの第２可視光信号は第１スペクトル範囲と異なる第２スペクトル範囲で与えられる。
Patent JP-2003506077-A (JP)
IPC: C12P21/00
Filed: 1999-08-05
Abstract: The invention relates to a stabile recombinant cell clone which is stabile in a medium containing no serum and proteins for at least 40 generations, and to a biomass which is obtained by multiplying the stabile cell clone under cultivation conditions that do not involve the use of serum or proteins. The invention also relates to a method for producing recombinant proteins using the biomass, to a method for producing stabile recombinant cell clones, and to the production of a recombinant protein in a synthetic minimal medium that does contain serum or proteins.
Patent JP-2003507228-A (JP)
IPC: B41J29/38
Filed: 2000-08-18
Abstract: A printer (10) which is configured to automatically transmit data, such as critical and non-critical printer data, and route that data through at least one of a plurality of communication channels and services, such as via e-mail or mobile wireless equipment (e.g. an Internet-ready pager (150), a Personal Communications Service (PCS) phone (160) or a wireless Personal Digital Assistant (PDA) (170)). Preferably, the printer is configured such that it can be programmed and controlled from a remote location. Preferably, the printer is configured such that new label formats can be added from a remote location, and label formats stored in the printer can be viewed and modified from a remote location. Preferably, the printer is also configured such that barcode rendering algorithms can be downloaded to the printer, and such that printer settings can be viewed and modified from a remote location, and thereafter can be downloaded to the printer and/or to other printers (10a, 10b, 10c) in a network to facilitate cloning.
Patent JP-2003531557-A (JP)
IPC: H02P6/12
Filed: 2000-09-20
Abstract: A method for controlling and protecting electric motors, specially permanent magnet motors electronically actuated by a control system. The system includes a three-phase inverting bridge, in which the position of the rotor can be monitored by using a position detector physically attached to the axle or through the tension induced in the coils by the magnet, in order to correctly control actuation by the control system. The present invention is also directed to a system for controlling electric motors and an electric motor system. The system includes continuously reading the position detector until a minimum expected time has passed. After the minimum expected time has passed, there is continuous reading of the position detector until a maximum expected time has passed to detect if a position change of the rotor is sensed.
Patent JP-2003511199-A (JP)
IPC: A61B17/56
Filed: 2000-10-17
Abstract: A surgical method of repair and reconstruction of the spinal disc wall (annulus) after surgical invasion or pathologic rupture, incorporating suture closure, or stent insertion and fixation, designed to reduce the failure rate of conventional surgical procedures on the spinal discs. The design of the spinal disc annulus stent allows ingrowth of normal cells of healing in an enhanced fashion strengthening the normal reparative process.
Patent JP-2004506598-A (JP)
IPC: A61K35/12
Filed: 2000-10-26
Abstract: A method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. The mesenchymal stem cells can be administered before, at the same time as, or after the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with mesenchymal stem cells.
Patent JP-2004500050-A (JP)
Title: 天然の又は相同なエクステインを利用するインテインスプライシングをブロック又は活性化する薬剤のスクリーニング及び使用
IPC: C12Q1/37
Filed: 2000-10-27
Abstract: 【課題】ネイティブな宿主タンパク質（エクステイン）において、または相同なエクステインにおいてインテインのスプライシングを制御する薬剤についてスクリーニングするための、選択系および方法を提供する。 【課題を解決する手段】本発明によれば、タンパク質スプライシングを阻害するかまたは活性化する薬剤をスクリーニングするためのポジティブな遺伝子選択系が提供され、これは：標的酵素または野生型標的酵素の薬物耐性の形態のいずれかをコードする染色体遺伝子、および薬物との相互作用の際に優性的に細胞障害性である標的酵素の薬物感受性の形態、または標的酵素の優性的に細胞障害性の形態のいずれかをコードするプラスミドに保有される遺伝子を含む宿主細胞を包含する。 【選択図】なし
Patent JP-2003514810-A (JP)
Title: インデン型またはジヒドロナフタレン型炭素環とｃ５−ｃ６において環化されたナフトピラン並びにそれらを含有する組成物およびマトリクス
IPC: C07D311/78
Filed: 2000-11-14
Abstract: (57)【要約】
本発明は、以下の化学式(I)および(II)のものである、インデン型またはジヒドロナフタレン型炭素環により位置Ｃ 5 −Ｃ 6 において環化された新規のナフトピラン型化合物に関する。これらの化合物(I)および(II)は、興味深いフォトクロミック特性を有する。本発明はまた、それらの調製、フォトクロームとしてのそれらの用途、並びにそれらを含有する組成物およびマトリクスにも関する。
Patent JP-2003526847-A (JP)
Title: 運搬および引き渡し可能状態が規制されたアイテムの引き渡しを促進するシステムおよび方法
IPC: G06Q30/06
Filed: 2000-11-15
Abstract: (57)【要約】
引き渡しおよび運搬の状態が規制されたアイテムの引き渡しを促進するサービスが提供される。上記サービスは、所有者、消費者ならびに上記規制されたアイテムを受信して配送する許可を有する小売業者および卸売業者などの中間業者の電子通信を促進する。このようなアイテムの販売を所望する所有者は、広告サイト、オークションサイトまたは全リストサイト上にアイテムを宣伝し得る。所有者は、サービスプロバイダを介して個人的トランザクションも行い得る。所有者と消費者との間でアイテムの販売に関する合意に達した後、次いで、上記サービスプロバイダは、上記小売業者および卸売業者と電子的に通信して、支払いと引き換えに、所有者から消費者に上記アイテムを物理的に引き渡す調整を行い得る。
Patent JP-2003516225-A (JP)
Title: アルキン及びジエンの選択水素化担持触媒
IPC: C07C11/167
Filed: 2000-12-06
Abstract: (57)【要約】
Ｃ ２ −Ｃ ５   ＋ オレフィン混合物におけるアルキン及びジエンの選択水素化触媒であって、上記触媒が、（ａ）周期表第１０族の金属、（ｂ）周期表第１１族の金属、及び（ｃ）必要により、周期表第１族又は第２族の金属化合物、を含み、且つこれらの金属を、シリカ、二酸化チタン、酸化ジルコニウム、スピネル、アルミン酸亜鉛、チタン酸亜鉛、アルミノシリケート又はこれらの物質の混合物から選択される担体に施し、第１１族の金属を触媒粒子の断面に均一に分散させ、そして第１０族の金属を触媒粒子表面近傍のエッジ層に含ませることを特徴とする触媒を開示している。かかる触媒は、第１１族の金属を、好ましくは担体それ自体の調製中に施し、好適な金属塩溶液を含浸させることによって製造される。
Patent JP-2003516766-A (JP)
Title: 形態形成タンパク質応答阻害エレメントを用いた、形態形成タンパク質アナログを同定するための方法および組成物
IPC: C12Q1/68
Filed: 2000-12-15
Abstract: (57)【要約】
本発明は、一般的に、形態形成タンパク質アナログを同定するための方法および組成物に関する。１つの実施形態において、本発明は、骨形成タンパク質応答転写阻害エレメントに関する。本発明はまた、遺伝子発現の調節および組織誘導能力に対する形態形成タンパク質の生物学的効果を模倣し得る、同定された形態形成タンパク質アナログ、特に、骨形成タンパク質（ＯＰ−１）のようなＢＭＰファミリーに関する形態形成タンパク質アナログに関する。
Patent JP-2003519722-A (JP)
IPC: B01D15/02
Filed: 2000-01-10
Abstract: A method and apparatus (101) for the recovery of fat soluble compounds, such as beta carotene, is described. In one embodiment of the invention a solution (102) containing a fat soluble compound is passed through a fluidised bed (104) of crystalline metallic ore particles, such as magnetite, allowing the fat soluble compound to bind to the particles to form a complex (109). The fat soluble compound is released from the complex (109) by passing a wash solution (107) through the fluidised bed and subsequently collected in solution (108). The crystalline metallic ore particles may be reused.
Patent JP-2004513276-A (JP)
Title: 燃料調量システムのデータを記憶及び／又は読み取るための方法及び装置
IPC: F02M51/00
Filed: 2001-01-17
Abstract: 燃料調量システムのデータ、とりわけ燃料ポンプ又は噴射器のデータを記憶及び／又は読み取るための方法及び装置が説明される。燃料ポンプ及び／又は噴射器のデータは、少なくとも１つの電子的コンポーネントに割当てられている。これらのデータは、燃料調量システムの制御の際に、制御ユニットにより考慮される。前記コンポーネントは、第１期間の間は、機械的及び／又は電気的に制御ユニットと接続されており、第２期間の間は、機械的及び／又は電気的に制御ユニット及び／又は燃料調量ユニットから切り離されている。
Patent JP-2003523306-A (JP)
IPC: H05B3/14
Filed: 2001-01-30
Abstract: The present invention relates to the provision of materials intended for use in an oxidative medium at high temperatures, including the manufacture of high-temperature electric heaters, parts, sensors and tools operating at temperatures of up to 1900 DEG C and higher. On the basis of silicides - solid solutions (Mo,W)5Si3 and (Mo,W)Si2 as well as Novotny phase (Mo,W)5Si3C containing molybdenum and tungsten, a heat-resistant material is proposed, which makes it possible to produce parts fully made therefrom and a broad range of other heat-resistant materials for the provision of protective coatings and soldered joints: "REFSIC" composite materials, carbon, silicon carbide materials, refractory metals and their alloys. Extensive property-varying potentialities by controlling the phase composition, a large diversity of the structural features of single-layered and multilayered protective coatings make it possible to control the heat-resistance, resistance to thermal shocks and resistance to combined thermal deformations of the coating as such and of parts produced by soldering other high-temperature materials with the help of the proposed heat-resistant material. The proposed electric heaters can have working parts and current lead-in wires made from the above-mentioned high-temperature materials, having soldered joints and protective coatings prom the proposed material in different combinations of materials and heater designs. <IMAGE>
Patent JP-2003523266-A (JP)
IPC: A61M5/50
Filed: 2001-02-22
Abstract: A single use syringe has a needle which is biased back into the barrel but which is prevented from doing so by a holding means which has an outer part and an inner part which are connected together by a frangible portion. The needle is held by the inner part. When the plunger is pushed towards the front of the barrel, it contacts the outer part and pushes it forwardly which stretches the frangible portion until it bursts. When the frangible portion breaks, the inner portion containing the needle is released and can shoot back into a hollow portion in the plunger through the frangible portion of the plunger head.
Patent JP-2003524037-A (JP)
Title: ニトロキシド官能基を持つ熱可逆性ポリマー
IPC: C09J201/06
Filed: 2001-02-15
Abstract: (57)【要約】
本発明は熱可逆性の特性を現す樹脂を得るために、多官能性ニトロキシドおよび場合によりフリーラジカルイニシエーターの存在下でポリマーを熱処理することにより、分枝化または架橋化された樹脂を調製する方法に関する。初期ポリマーはゴムまたは熱可塑性ポリマーでよい。得られた樹脂は初期ポリマーと同じ使用条件を提供すると同時に、強化された機械的特性を現す。
Patent JP-2003528101-A (JP)
Title: ５−アルキルピリド［２，３−ｄ］ピリミジンチロシンキナーゼ阻害剤
IPC: A61K31/5375
Filed: 2001-01-29
Abstract: (57)【要約】
式(Ｉ)[式中、R 2 は水素、アルキルまたはシクロアルキルであり；R 3 は水素、低級アルキル、低級アルコキシ、ハロゲン、トリフルオロメチル、低級アルキニル、低級アルケニル、ニトリル、ニトロ、-COR 4 、-CO 2 R 4 、-CONR 4 R 5 、-CONR 4 OR 5 、-SO 2 NR 4 R 5 、-SO 2 NR 4 R 5 、-SO 2 R 4 、-SO 3 R 4 、式(II)または-NR 4 R 5 であり；ＹはＮまたはCR 7 であり；R 9 は低級アルキル、ハロアルキルまたはアリールであり；ＸおよびＺは独立して水素、ハロゲン、低級アルキル、低級アルコキシ、トリフルオロメチル、ヒドロキシ、ニトリル、ニトロ、-NR 4 R 5 、-N(O)R 4 R 5 、-NR 4 R 5 R 6 W、-SR 4 、-C(O)R 4 、-CO 2 R 4 、-CONR 4 R 5 、-SO 2 NR 4 R 5 、-SO 2 R 4 、-SO 3 R 4 、P(O)(OR 4 )(OR     5 )、-T(CH 2 ) m QR 4 、-C(O)T(CH 2 ) m QR 4 または-NR 4 C(O)T(CH 2 ) m QR 5 であり；ｍは１〜６である］に示される化合物を開示する。これらの化合物は癌、アテローム性動脈硬化症および再狭窄のような細胞増殖性疾患の治療のために有用である。化合物はサイクリン依存性キナーゼ(cdk)および増殖因子仲介キナーゼの強力な阻害剤である。
【化１】
Patent JP-2003531203-A (JP)
IPC: A61P9/12
Filed: 2001-04-20
Abstract: A Process is disclosed for preparing a compound of the Formula (I)which comprises the steps of:(a) detritylating a compound of the Formula (III)with 0.1 to 1 equivalent of potassium hydroxide in a C1 to C4 straight chain alcohol solvent to obtain a reaction mixture containing the compound of the Formula (I),(b) changing the C1 to C4 straight chain alcohol solvent in the reaction mixture to an aprotic solvent or a weakly protic solvent, and(c) following step (b) crystallizing out the compound of the Formula (I) from the reaction mixture.