baber/WOPTO huggingface dataset:
Patent CA-2428248-A1 (CA)
Inventor: KNUTH MARK
IPC: C12Q1/68
Filed: 2001-11-21
Abstract: The present invention provides polynucleotides that a protein solubility response promoter operatively liked to a reporter gene and a genetic reporter system comprising these polynucleotides together with an expression construct for a target protein. The invention also provides cells comprising polynucleotides of the invention and the genetic reporter system. These compositions are useful to monitor the solubility of a target protein in a cell and to identify mutations to the cell or mutations to a polynucleotide encoding the target protein that alters the solubility of the target protein.  The invention further provides method to identify variations in a protein biosynthetic process that alter the solubility of a target protein and methods to screen an expression library of recombinant clones to identify clones that express soluble proteins. Finally, the invention discloses a novel method of identifying an antibiotic agent.
Patent CA-2429769-A1 (CA)
Inventor: RAJAGOPAL RAMESH
IPC: A61P43/00
Filed: 2001-12-07
Abstract: The present invention relates to gene therapy methods for the treatment of human disease. More specifically, the invention is directed to methods for treating a subject with an angiogenesis-related disease. In one embodiment, an adenoviral expression construct comprising a nucleic acid encoding a human MDA-7 protein under the control of a promoter operable in eukaryotic cells, is administered to said patient with a angiogenesis-related disease. The present invention thus provides for treatment of angiogenesis-related disease by through expression of mda-7 and inhibition angiogenesis. Such diseases include cancer.
Patent CA-2431193-A1 (CA)
Inventor: CHIEN KENNETH
IPC: A61K48/00
Filed: 2001-12-05
Abstract: The invention relates to novel promoter sequences derived from a portion upstream of the coding sequence of the gene for the CARP protein (Cardiac Ankyrin Repeat Protein), and which are capable of controlling the level and the specificity of expression of a transgene in vivo in cardiac muscle cells . The invention thus describes novel compositions, constructs, vectors and the ir uses in vivo for the transfer and expression of a nucleic acid in vivo in cardiac muscle cells. The subject of the present invention is also the use o f the promoter sequences for generating transgenic animals which constitute models for studying certain cardiac pathologies.
Patent CA-2435406-A1 (CA)
Title: Guidance unit for coveyor belt
Inventor: HOVSTO KENNETH
IPC: B65G39/16
Filed: 2002-01-04
Abstract: The present invention relates to a belt guidance unit for centring a conveyor belt, which during operation is susceptible to lateral displacement away from a neutral position in its longitudinal direction. According to the invention the belt guidance unit can be employed on conveyor belts that move in one direction as well as in two opposite directions with only very slight alterations and the basic constructional features of the belt guidance unit are substantially identical in the two operational situations.
Patent CA-2437286-A1 (CA)
Title: Microsurgical robot system
Inventor: SUTHERLAND GARNETTE ROY
IPC: A61B19/00
Filed: 2003-08-13
Abstract: 46 A robot system for use in surgical procedures has two movable arms each carried on a wheeled base with each arm having a six of degrees of freedom of movement and an end effector which can be rolled about its axis and an actuator which can slide along the axis for operating different tools adapted to be supported by the effector. Each end effector including optical force sensors for detectin g forces applied to the tool by engagement with the part of the patient. A microscope is located at a position for viewing the part of the patient. The position of t he tool tip can be digitized relative to fiducial markers visible in an MRi experiment. The workstation and control system has a pair of hand-controllers simultaneously manipulated by an operator to control movement of a respective one or both of the arms. The image from the microscope is displayed on a monitor in 2D and stereoscopically on a microscope viewer. A second MRi display shows an image of the part of the patient the real-time location of the tool. The robot is MRi compatible and can be configured to operate within a closed magnet bore. The arms are driven about vertical a nd horizontal axes by piezoelectric motors.
Patent CA-2437979-A1 (CA)
Inventor: YANG JIACHENG
IPC: C12Q1/68
Filed: 2003-08-14
Abstract: The present invention relates to molecular constructs and methods of their use in detecting biochemical reactions. In particular, the invention relates to a molecular construct having a capture portion and a substrate portion, where the capture portion isolates the construct from a sample medium, and the substrate portion enables the construct to be acted upon and undergo a physical change which can be detected and measured. These molecular constructs may be used in diagnostic assays, genetic screening for potential risks of certain diseases in individuals, and drug discovery and toxicogenomics, using high throughput screening of compounds.
Patent CA-2440931-A1 (CA)
Title: Hiv protease inhibitors based on amino acid derivatives
Inventor: YELLE JOCELYN
IPC: C07C323/60
Filed: 2002-02-12
Abstract: A compound selected from the group consisting of a compound of formula I or formula II: (I) (II) wherein n is 3 or 4 wherein Cx is selected from the group consisting of -COOM, COOR6, -CHO, -CH2OR7, -CH2OCOR8, -CONHR9 and -CONR10R11, wherein M is an alkali metal or alkaline earth metal, wherein R2 is selected from the group consisting of a benzenesulfonyl group of formula III, or formula IV : (III) (IV) and when the compound of formula (I) and (II) comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.
Patent CA-2441130-A1 (CA)
Inventor: ARAI YUJI
IPC: B21C1/24
Filed: 2002-03-11
Abstract: (1) A steel pipe that is expanded radially in a state wherein it was inserted in a well such as an oil well, characterized in that the non-uniform wall thickness ratio E0 (%) before expanding satisfies the following expression ~.    E0 .ltorsim. 30 /(1 + 0.018 .alpha.) .multidot. ~     Wherein .alpha. is the pipe expansion ratio (%) calculated by the following expression ~.   .alpha. = [(inner diameter of the pipe after expanding - inner diameter of the pipe before expanding)/inner diameter of the pipe before expanding] ×  100 .multidot.~   (2) A steel pipe that should be expanded radially in a state wherein it is inserted in a well, such as an oil well, characterized in that the eccentric non-uniform wall thickness ratio is 10 % or less.     When the embedding-expanding method is performed with use of the steel pipe of (1) or (2), lowering of collapse strength of the expanded steel pipe is prevented and bending thereof can be decreased.
Patent CA-2441292-A1 (CA)
Inventor: MELLENCAMP MARK W
IPC: A61K39/39
Filed: 2002-01-23
Abstract: A vaccine for protecting a horse against diseases associated with EHV-1 and/ or EHV-4 is provided. The vaccine commonly includes inactivated EHV-1 (e.g., chemically inactivated EHV-1 KyA virus), using ethylenimine and an adjuvant. The adjuvant can include a cross-linked olefinically unsaturated carboxylic acid polymer which may have bioadhesive properties. The vaccine may also include antigens against other equine pathogens such as inactivated EHV-4 an d inactivated A1 and/or A2 strains of equine influenza virus. Methods for protecting horses against diseases associated with EHV-1 and/or EHV-4 and methods of producing the equine herpesvirus vaccine are also provided.</SDOA B>
Patent CA-2441834-A1 (CA)
Inventor: SECKL JONATHAN ROBERT
IPC: A61K48/00
Filed: 2002-03-25
Abstract: L'invention concerne l'utilisation d'un agent permettant de réduire des niveaux de 11.beta.-HSD1 dans la fabrication d'une composition pour la promotion d'un profile lipidique athéroprotecteur.
Patent CA-2442685-A1 (CA)
Title: Estrogen receptor-related receptor alpha (err.alpha.) and cartilage formation
Inventor: BONNELYE EDITH
IPC: A61K31/56
Filed: 2002-04-04
Abstract: Estrogen related receptor .alpha. (ERR.alpha.) is involved in control of cartilage formation in mammals. Increasing ERR.alpha. activity causes stimulation of cartilage formation, providing a means of therapeutic intervention in diseases such asarthritis which involve cartilage destruction.  Compounds may be screened for their potential as therapeutics by screening their effect on ERR.alpha. cartilage promoting activity.
Patent CA-2442973-A1 (CA)
Inventor: ANDERSON ROBB G
IPC: F04D13/10
Filed: 2003-09-26
Abstract: A control system for the operation of a centrifugal pump which may be used for production of gas and/or oil from a well. The control system includes vector feedback model to derive values of torque and speed from signals indicative of instantaneous current and voltage drawn by the pump motor, a pump model which derives values of the fluid flow rate and the head pressure for the pump from torque and speed inputs, a pumping system model that derives from the estimated values of the pump operating parameters an estimated value of a pumping system parameter and controllers responsive to the estimated values of the pumping system parameters to control the pump to maintain fluid level at the pump input near an optimum level.
Patent CA-2444168-A1 (CA)
Inventor: HAUGHTON GARY
IPC: B01F11/00
Filed: 2002-04-17
Abstract: A mixer apparatus for use with a vessel centered about a longitudinal axis is disclosed. The mixer has a tubular blade which: defines a central head axis; has a first end and a second end spaced from the first end along the head axis; and tapers from the first end to the second end. The outer surface of the blade and the second end define an inside blade diameter "ID" and the outer surface of the blade and the first end define an outside blade diameter "OD". The blade is positioned within and coaxial to the vessel. A scotch yoke, operatively connected to the blade by a shaft, effects reciprocating longitudinal movement of the blade through a stroke "S", with a duration "T" for each stroke, wherein 175 <= 0.36 × OD2/ID2 ×S/T <= 250 when OD, ID and S are expressed in inches, and T is expressed in minutes.
Patent CA-2444814-A1 (CA)
Inventor: NEWBY DANIEL GARY
IPC: A61K9/48
Filed: 2001-10-24
Abstract: The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent; b. an inner coating layer selected from the group consisting of poly(methacrylic acid, methyl methacrylate) 1:2, poly(methacrylic acid, methyl methacrylate) 1:1, and mixtures thereof; and c. an outer coating layer comprising an enteric polymer or film coating material; wherein the inner coating layer is not the same as the outer coating layer; wherein if the inner coating layer is poly(methacrylic acid, methyl methacrylate) 1:1 then the outer coating layer is not poly(methacrylic acid, methyl methacrylate) 1:2 or is not a mixture of poly(methacrylic acid, methyl methacrylate) 1:1 and poly(methacrylic acid, methyl methacrylate) 1:2; and wherein the inner coating layer and the outer coating layer do not contain any therapeutically active agent. This invention further relates to a method of maintaining the desired site of delivery of a therapeutic agent in the gastrointestinal tract by administering the above compositions to a human or lower animal.
Patent CA-2446258-A1 (CA)
Inventor: MITSKY TIMOTHY
IPC: C12N15/29
Filed: 2002-05-03
Abstract: The present invention provides a method for conferring tolerance to an amino acid analog of tryptophan to a plant and/or altering the tryptophan content of a plant by introducing and expressing an isolated DNA segment encoding an anthranilate synthase in the cells of the plant. Transgenic plants transformed with an isolated DNA segment encoding an anthranilate synthase, as well as human or animal food, seeds and progeny derived from these plants, are also provided.
Patent CA-2447118-A1 (CA)
Title: Method and compositions for inhibiting thrombin-induced coagulation
Inventor: DAVIS STACEY
IPC: A61K38/16
Filed: 2002-05-13
Abstract: A method of achieving safe and effective treatment or prevention of potentially harmful blood clots, or in inhibiting the coagulation of blood when so desired such as during a wide array of disease conditions including stroke, myocardial infarction, sickle-cell crisis and venous thrombosis, is provided by the administration of a fibrinogen-binding protein capable of binding at the N-terminal B.beta. chain of fibrinogen, such as SdrG or Fbe, or their respective binding regions such as the A domain. In addition, compositions comprising effective amounts of the fibrinogen-binding proteins are also provided. The present anti-coagulation compositions have been shown to inhibit thrombin-induced fibrin clot formation by interfering with the release of fibrinopeptide B and the resulting anti-coagulation effects can be achieved without potential for causing or exacerbating unwanted side effects such as thrombocytopenia associated with prior art anticoagulants such as heparin.
Patent CA-2447513-A1 (CA)
Title: Compositions and methods for treating tumors bearing hmfg and cea antigens
Inventor: FOON KENNETH A
IPC: A61K39/00
Filed: 2002-05-17
Abstract: The present invention provides methods and compositions for treating HMFG-an d CEA-associated tumors using an anti-idiotype antibody for HMFG, such as antibody 11D10, in conjunction with an anti-idiotype antibody for CEA, such as antibody 3H1.
Patent CA-2448026-A1 (CA)
Title: Publicite en ruban sur des etiquettes detachables
Inventor: LACOSTE JUDE
IPC: G09F23/10
Filed: 2003-11-10
Abstract: Dans un ruban contenant des billets ou des étiquettes détachables on sait qu e les étiquettes ou les billets sont la plus part du temps imprimés d'informations relatives à un tirage ou donne de l'information de base sur un produit. Dans la présente invention l'étiquette est imprimée de publicités et le ruba n d'étiquettes est soit mis en rouleau ou plié et insérée dans une distributrice d'étiquett es ou de billets.
Patent CA-2450833-A1 (CA)
Title: Compositions comprising thylakoids useful in the modulation of the inflammation process
Inventor: ANDERSEN ALAIN
IPC: A61P29/00
Filed: 2002-07-02
Abstract: This invention relates to the use of a thylakoid extract that is preferably stabilized and activable for treating inflammation. Different types of cell or tissue targets and inflammatory stimuli have been used to evaluate the performance of the extract, which, in all cases successfully modulate inflammation through a balance of pro/anti-inflammatory cytokines.  Compositions comprising the extract and other anti-inflammatory agents, namely glucocorticoids or NSAIDs are further disclosed and claimed.
Patent CA-2451599-A1 (CA)
Inventor: BUCHANAN J SCOTT
IPC: B01D71/24
Filed: 2002-05-03
Abstract: L'invention concerne un procédé de séparation d'au moins un fluide à faible polarité d'un mélange de fluides à polarités différentes. Ce procédé consiste à mettre en contact au moins une membrane polymère à faible polarité ou non polaire avec le mélange de fluides dans des conditions telles que le fluide à faible polarité traverse de manière sélective la membrane, celle-ci possédant un rapport d'hétéroatomes chimiquement liés aux atomes de carbone dans la membrane au nombre d'atomes de carbone inférieur à environ 0,2, de préférence, inférieur à environ 0,05.
Patent CA-2454025-A1 (CA)
Title: Extraction de polysaccharides d'une substance vegetale et microbienne
Inventor: EKHART PETER FRANK
IPC: A23L29/10
Filed: 2002-07-17
Abstract: Des polysaccharides utiles tels que des .beta.-1,3-glucans issus d'une matière première végétale peuvent être solubilisés et/ou isolés en traitant la matière première avec un agent d'oxydation qui entraîne l'oxydation des groupes hydroxyle primaires dans le glucan. L'agent d'oxydation est de préférence une quantité catalytique d'un composé nitroxyle en présence d'un agent de réoxydation tel qu'un hypochlorite ou une enzyme oxydante avec l'oxygène ou le peroxyde d'hydrogène. Le polysaccharide conserve ses propriétés utiles pendant ce traitement et est, en outre, plus facilement disponible. Si on le souhaite, on peut également utiliser la matière protéinique de la matière première.
Patent CA-2454470-A1 (CA)
Title: Dosages destines a identifier et/ou quantifier des contaminants, et compositions utilisees pour ces dosages
Inventor: BELLEMARE FRANCOIS
IPC: G01N33/543
Filed: 2002-07-23
Abstract: L'invention concerne un procédé de dosage destiné à identifier et/ou quantifier au moins un contaminant dans un échantillon. Le procédé consiste à: a) mélanger l'échantillon avec des liposomes ayant un rendement de captation connu, de façon à former un mélange; b) isoler desdits mélanges les liposomes comprenant les liposomes liés au contaminant; c) détecter et quantifier le contaminant piégé; d) déterminer la concentration du contaminant dans l'échantillon en multipliant le rendement de captation avec la quantité de contaminant déterminé à l'étape c), la composition lipidique des liposomes possédant des affinités pour ledit contaminant si bien que, lorsque l'échantillon contient des contaminants, au moins une partie de ceux-ci est liée à ou piégée par les liposomes. Les contaminants peuvent être isolés ou même concentrés dans les liposomes pendant le processus de dosage. Les dosages de l'invention sont avantageux en ce qu'il peuvent être réalisés de manière simple et bon marché, et conviennent particulièrement pour des essais devant être effectués hors de laboratoires perfectionnés.
Patent CA-2454672-A1 (CA)
Title: Modular acetabular cup, and anchoring screw for fixing a prosthetic implant such as said acetabular cup
Inventor: MACARA FREDERIQUE
IPC: A61B17/80
Filed: 2002-07-22
Abstract: The invention concerns a modular acetabular cup for surgical treatment for hip joint reconstruction in cases of total recovery of hip implant, and an anchoring screw for fixing a prosthetic implant such as said acetabular cup. The prosthetic acetabular cup comprises a support-plate (1) designed to be arranged in the acetabular cavity and anchored by means of an anchoring screw (4) including means (48) for adjusting the positioning and the locking in depth of said support-plate (1) and an adjustable spacer (2) locked thereon by a tapered shank assembly system (16, 21) and further a metal acetabular shell (3) designed to be assembled to said spacer (2) by a tapered shank assembly system (24, 33).
Patent CA-2456784-A1 (CA)
Title: Circuit arrangement and method for an illumination device having settable color and brightness
Inventor: BOULOUEDNINE MOURAD
IPC: H05B44/00
Filed: 2004-02-03
Abstract: It is intended to be possible to use a respective setting apparatus (E1, E2) to set the color and the brightness of an illumination device separately. Light sources having three different colors are operated for this purpose. Only one first power supply (CON, PWM1) is provided for two colors, whereas the third color is supplied by a second power supply (CON, PWM2). The brightness can be set by altering the power output of the first (CON, PWM1) and the second (CON, PWM2) power supplies at the same time. The color can be set by altering the power output of the second (CON, PWM2) power supply.
Patent CA-2457632-A1 (CA)
Inventor: SIMMONS PAUL JOHN
IPC: C12N5/074
Filed: 2002-08-15
Abstract: The present invention relates to the identification of a specific population of cell types, in particular somatic stem cells including haematopoietic ste m cells, mesenchymal stem cells and keratinocyte stem cells. The invention als o provides for methods of isolation and uses of the stem cells. Derived from t he methods of the present invention, there is provided a method of identifying a stem cell comprising the steps of: obtaining a cell sample including stem cells; detecting the presence of angiotensin converting enzyme (ACE) or a fragment thereof on a cell; and identifying the stem cells having ACE or a fragment thereof.
Patent CA-2459762-A1 (CA)
Title: Method and device for preserving perishable products
Inventor: VEILLON JACQUES
IPC: B65D81/20
Filed: 2002-09-13
Abstract: The invention concerns a method for preserving perishable products (10) arranged in a container (1), comprising a step which consists in fixing a flexible envelope (2) including at least a projecting tab (5, 5', 5'' and 6), on at least part of the ends of said container so as to form a fluid-tight housing (8) for the products. The invention is characterized in that it comprises the following steps, for expelling fluid, for example ambient air, contained in said housing: a) a drawing step which consists in stretching at least one of said tabs (5, 5' or 5'') so as to form a temporary passage between the inside and the outside of said housing (8); b) a step which consists in compressing, or pressing, the flexible envelope (2) against the products and/or the container so that the fluid contained in said housing (8) is expelled through said temporary passage; c) a step which consists in closing said passage.
Patent CA-2460149-A1 (CA)
Title: 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same
Inventor: HOSHINA YOICHIRO
IPC: C07D277/46
Filed: 2002-09-03
Abstract: A 2-phenyl-3-heteroarylpropionic acid derivative or a salt thereof; a medici ne containing the derivative or salt as an active ingredient; and a VLA-4 and/or LPAM-1 antagonist.
Patent CA-2460249-A1 (CA)
Title: Process for chilling animal carcasses
Inventor: KAMINSKI ROBERT T
IPC: A22B5/00
Filed: 2004-03-09
Abstract: A process for cooling animal carcasses from a kill temperature to a temperature at which deterioration is substantially prevented comprises circulation of refrigerated air over the carcass to freeze an outer layer of the carcass, followed by application of water to the carcass to form a sufficiently continuous layer of ice on the carcass.  Preferably, the carcass is chilled by a multi-stage quick chill process in which the carcass is exposed to super-cooled, high velocity air. Immediately before or immediately after formation of the ice layer, the carcass is transferred to a refrigerated chamber to allow the interior and exterior of the carcass to equilibrate to the temperature at which deterioration is substantially prevented. The inventors have found that this process provides reduced moisture loss and reduced bacterial loading over prior art processes in which water is applied to the carcass during the quick chill process.
Patent CA-2460316-A1 (CA)
Inventor: SHIRODKAR PRADEEP P
IPC: C08F2/00
Filed: 2002-07-09
Abstract: L'invention concerne un procédé permettant la préparation de polyoléfines présentant une répartition large ou bimodale de masse moléculaire, et comprenant une propriété cible, telle qu'indice d'écoulement, taux d'écoulement à l'état fondu, ou fractions en masse de composants à masse moléculaire plutôt élevée ou à masse moléculaire plutôt faible. Ce procédé fait appel à un catalyseur bimétallique contenant un composant métallocène et un composant non métallocène, et les activités des fraction métallocène et non métallocène sont réglées par dosage du taux de cocatalyseur organo-aluminium et méthylaluminoxane modifié. Ce procédé permet de surveiller et de régler les propriétés d'une polyoléfine en temps réel, pendant la formation de la polyoléfine.