baber/WOPTO huggingface dataset:
Patent IE-71649-B1 (IE)
Title: Anticalculus/antiplaque compositions using azacycloalkane diphosphonates
Inventor: NELSON DENNIS GEORGE ANTHONY
IPC: A61K8/34
Filed: 1991-07-12
Abstract: Azacycloalkane diphosphonates are used in combination with antimicrobials, especially 5-chloro-2-(2,4-dichlorophenoxy)phenol, to provide anticalculus and antiplaque benefits on teeth. Oral care compositions such as dentifrices, mouthwashes and the like, are provided.
Patent IE-46010-B1 (IE)
Title: New corticoids
IPC: C07J5/00
Filed: 1977-12-07
Abstract: Compounds of the formula wherein X is beta -CH2OH or CO and R2 is F, Cl or CH3, and their physiologically acceptable 21-esters are useful for the treatment of allergic diseases of the respiratory tract and for the treatment of topical and systemic inflammatory conditions.
Patent IE-54857-B1 (IE)
Title: 3-(4-piperidyl)-1,2-benzisoxazoles, process for the preparation thereof and a pharmaceutical composition comprising the same
IPC: C07D413/04
Filed: 1982-11-11
Abstract: Novel 3-(4-piperidyl)-1,2-benzisoxazoles, intermediates and processes for the preparation thereof, and their use for alleviating pain are disclosed.
Patent IE-57593-B1 (IE)
Title: Method of and medium for storing blood platelets
IPC: A61K35/14
Filed: 1984-11-08
Abstract: A novel method of processing and storing human blood platelets is disclosed which comprises the replacement of about 35-45 mls of plasma per unit of blood platelets with a synthetic storage medium. This synthetic storage medium comprises a buffered Ringers-citrate solution which preferably contains a platelet permeable substrate for oxidative phosporylation. In the resultant platelet suspension, the amount of glucose available for glycolysis is preferably limited to less than about 10 mM, preferably less than about 5.0 mM. This platelet suspension is stored in an oxygen permeable container at about 20 DEG -24 DEG C. until needed for use. Using this method and medium platelets will maintain their viability for up to as long as about 7 days.
Patent IE-64737-B1 (IE)
Title: New isoindolone derivatives and their preparation
Inventor: DUBROEUCQ MARIE-CHRISTINE
IPC: A61P43/00
Filed: 1990-11-22
Abstract: New isoindolone derivatives of general formula (I) are   <IMAGE> (I) disclosed in which the radicals R represent hydrogen atoms or, together, form a bond, the symbol R' represents a hydrogen atom or a readily removable radical and the symbols R'' are identical and represent phenyl radicals which can be substituted with a halogen atom or a methyl radical at the ortho or meta position, in the (3aR, 7aR) form or in the form of a mixture of the (3aRS, 7aRS) forms, as well as their salts. These derivatives are useful as intermediates for the preparation of therapeutically active products.
Patent IE-80823-B1 (IE)
Title: Optical communications system
Inventor: AINSLIE BENJAMIN JAMES
IPC: H04B10/272
Filed: 1991-12-11
Abstract: An optical telecommunications system suitable for operation as a wavelength division multiplex, which system contains at least one filter for attenuating signals at wavelength which are unwanted at the location of the filter, characterised in that the filter comprises an optical fibre which contains a dopant adapted to absorb the unwanted signals.
Patent IE-66255-B1 (IE)
Title: Slow-release pharmaceutical composition
Inventor: IIDA YOSHIMITSU
IPC: A61K9/50
Filed: 1986-09-16
Abstract: A slow-release pharmaceutical composition which comprises fumaric acid and/or DL-tryptophan in addition to one or more pharmaceutically active substances, and a process for preparing the same are disclosed. Among many organic acids and amino acids, fumaric acid and DL-tryptophan are remarkably useful for extending the duration of release of a pharmacologically active substance when fumaric acid, DL-tryptophan or both are used for the formulation of a pharmaceutical composition. The pharmaceutical composition may be in any solid form of formulations such as powder, granule, tablet, troche, capsule, suppository, etc., and may be used with practically all types of drugs.
Patent LU-101995-B1 (LU)
Title: Spliced pavement construction equipment
Inventor: WANG CHANGBAI
IPC: E01C9/00
Filed: 2020-08-21
Granted: 2021-03-08
Abstract: The present invention discloses spliced pavement construction equipment, including a fixed frame, where movable parts are symmetrically distributed below the fixed frame, first hydraulic cylinders are symmetrically distributed on the fixed frame, a vibrating part is disposed on the fixed frame, a second hydraulic cylinder is disposed on the vibrating part, a first vibration motor is disposed on the vibrating part, a driven roller is rotatably disposed inside the fixed frame, a troweling part is disposed below the fixed frame, and a second vibration motor is disposed on the troweling part; and the vibrating part includes a vibrating frame, a support pillar is disposed below the vibrating frame, vibrating rods are distributed as an array in the support pillar, and a first elastic part is disposed below the vibrating frame. The construction equipment of the present invention adjusts heights of the vibrating rods and the troweling part through the hydraulic cylinders. The vibration motor drives the vibrating rods and the troweling part to vibrate. A high mixing degree of the concrete reduces internal cavities and ensures smoothness of the pavement, leading to a good troweling effect and high efficiency.
Patent LU-500706-B1 (LU)
Title: Verfahren zum Ziehen eines Drahtes vor dem Schweißen an einer Heckschubbasis
Inventor: LI CHUANJIANG
IPC: B63B73/60
Filed: 2021-09-30
Granted: 2022-11-08
Abstract: Die Erfindung betrifft ein Verfahren zum Ziehen eines Drahtes vor dem Schweißen an einer Heckschubbasis, wobei das Verfahren die folgenden Schritte umfasst: Schritt 1. Zeichnen der Längsmittellinie FaFb, der Quermittellinie P1S1 und der Querachsenmittellinie P2S2 auf der backbordseitigen und steuerbordseitigen Heckschubbasis, und Aufprägen einer Stanzmarke; Schritt 2. Ermitteln des Mittelpunkts Oa der Heckschubwelle an Backbord und Steuerbord, wobei der Mittelpunkt Oa der Heckschubwelle an Backbord und Steuerbord und die Höhe des Mittelpunkts Oa durch eine vertikale Bezugslinie AB der Heckschubwelle an Backbord und Steuerbord bestimmt wird; Schritt 3. Bestimmen der Ebenenposition der Heckschubbasis an Backbord; Schritt 4. Wiederholen des Schritts 3, um die Ebenenposition der Heckschubbasis an Steuerbord zu bestimmen. Mit dem durch die vorliegende Erfindung bereitgestellten Verfahren ist es möglich, die endgültige Bestimmung der ebenen Position der Heckschubbasis zu erhalten, genaue Daten für die Positionierung und Verarbeitung der Basis bereitzustellen und die Erfolgsrate bei der Installation nachfolgender Antriebsausrüstung zu verbessern.
Patent LU-501468-B1 (LU)
Title: Preparation method and application of ionized chitosan-sodium alginate composite film
Inventor: TANG XIUJUAN
IPC: C08B37/00
Filed: 2022-02-15
Granted: 2022-08-16
Abstract: The preparation method of that new composite membrane comprises the following steps: (1) dissolving sodium alginate in distilled water to prepare sodium alginate solution, and swelling at room temperature for 30 min; (2) heating the solution in step (1) in water bath and stirring at a constant speed; (3) reducing the temperature of the solution in step (2) to 40 degree Celsius, and adding glycerol as a plasticizer; (4) adding ionized chitosan, and finally preparing the ionized chitosan-sodium alginate composite membrane solution with the mass concentration of ionized chitosan of 0.5 percent-1.5 percent. If the perilla anthocyanin solution is added in the third step, the perilla anthocyanin-ionized chitosan-sodium alginate composite film can be prepared. The invention has the characteristics of high dipping film-forming speed, good bacteriostasis and so on, and has wide source of raw materials, low price and wide application prospect.
Patent NO-300323-B1 (NO)
Inventor: MOLDT PETER
IPC: A23L17/00
Filed: 1991-01-31
Abstract: The present invention relates to a process for the preparation of astaxanthin having the formula <CHEM> comprising the step of oxidizing a dienolether, a dienamine, or a dienolate anion of canthaxanthin with an oxaziridine oxidant to produce an astaxanthin dihemiaminal, and then decomposing the dihemiaminal to produce astaxanthin. The process advantageously involves two less steps than the best known prior art process for the preparation of astaxanthin. The invention also relates to important intermediates in the preparation of astaxanthin, which is itself an important additive in the fish industry, the most important of which intermediates is the astaxanthin dihemiaminal.
Patent NO-307078-B1 (NO)
Inventor: SNORRASON ERNIR
IPC: A61K31/365
Filed: 1993-11-12
Abstract: The use of a pharmaceutically acceptable cholinesterase inhibitor or a prodrug therefor for counteracting the sedative, hypnotic or respiratory depressive effects of benzodiazepines, substantially without interfering with the anxiolytic, antipsychotic, anticonvulsant, and muscle relaxant activity of benzodiazepines, especially the benzodiazepines used for treatment of diseases where the sedative, hypnotic or respiratory depressive effects are undesirable, such as diseases selected from the group consisting of anxiety, anxiety neurosis, anxiety reactions, panic reactions, schizophrenia, affective or schizoaffective type schizophrenia, borderline psychosis, agitating endogene depressions, hyperactivity in children, and muscle spasms; the use of a pharmaceutically acceptable cholinesterase inhibitor or a prodrug therefor for the treatment of schizophrenia, in particular affective or schizoaffective type schizophrenia. The acetyl cholinesterase is preferably one that acts substantially selectively at nicotinic receptor sites, and which has selectivity for acetyl cholinesterase opposed to butyryl cholinesterase, e.g. galanthamine or a galanthamine derivative.
Patent NO-316451-B1 (NO)
Inventor: FILMUS JORGE
IPC: C12N5/10
Filed: 1994-09-29
Abstract: PCT No. PCT/CA93/00130 Sec. 371 Date Oct. 20, 1994 Sec. 102(e) Date Oct. 20, 1994 PCT Filed Mar. 30, 1993 PCT Pub. No. WO93/20218 PCT Pub. Date Oct. 14, 1993Synthetic inducible eukaryotic promoters for the regulation of transcription of a gene achieve improved levels of protein expression and lower basal levels of gene expression. Such promoters contain at least two different classes of inducible elements, usually by modification of a native promoter containing one of the inducible elements by inserting the other of the inducible elements. In embodiments, additional metal responsive elements (MREs) and/or glucocorticoid responsive elements (GREs) are provided to native promoters, particularly the hMT-IIA and MMTV-LTR promoters. One or more constitutive elements may be functionally disabled to provide the lower basal levels of gene expression.
Patent NO-307546-B1 (NO)
Inventor: BARBERICH TIMOTHY J
IPC: A61P25/04
Filed: 1995-06-16
Abstract: Methods are disclosed utilizing optically pure R-ketorolac for the treatment of pain, including but not limited to pain associated with toothaches, headaches, sprains, joint pain and surgical pain, for example dental pain (e.g., after periodontal surgery) and ophthalmic pain (e.g., after cataract surgery) while avoiding adverse effects which are associated with the administration of the racemic mixture of ketorolac. The optically pure R-ketorolac is also useful in treating pyrexia while avoiding the adverse effects associated with the administration of the racemic mixture of ketorolac.
Patent NO-318020-B1 (NO)
Inventor: LUDESCHER JOHANNES
IPC: C07F7/10
Filed: 1996-10-23
Abstract: Intermediates in the production of cephalosporins of formula <CHEM>     wherein either   alpha ) R<a> denote hydrogen or a silyl group; R<b> denotes a group of formula -OR<e>, wherein R<e> denotes hydrogen or alkyl; and R<c> and R<d> together denote a bond; or beta ) R<d> and R<a> denote hydrogen or a silyl group; and R<b> and R<c> together denote an imino group of formula = N - Y, wherein Y denotes alkyl, aryl or heterocyclyl; or gamma ) R<d> denotes hydrogen or a silyl group; R<a> denotes hydrogen, if R<d> denotes hydrogen; or, R<a> denotes hydrogen or a silyl group, if R<d> denotes a silyl group; and R<b> and R<c> together denote the oxo group; in free form or in salt form.l
Patent AT-512527-B1 (AT)
Title: Buch
Inventor: KERN ALEXANDER
IPC: B42D1/00
Filed: 2012-02-21
Granted: 2013-09-15
Abstract: Die Erfindung betrifft ein Holzbuch (1) mit einer Deckseite (2), einer Rückseite (7) und Furnierseiten (3). Führungsnuten (4, 5) sind in auf der Rückseite (7) geleimte Holzklötze (6) eingefräst und die Seiten (2, 3) werden mittels eingeleimter Holzrundstäbe (8) in den Führungsnuten (4, 5) geführt.
Patent AT-508919-B1 (AT)
Title: Sarg mit sargkörper und deckel
IPC: A61G17/00
Filed: 2010-03-01
Granted: 2011-05-15
Abstract: Die Erfindung betrifft einen Sarg mit Sargkörper (1) und Deckel, wobei Der Sargkörper und der Deckel aus Zuschnitten (1’) von Wellpappe durch Falten hergestellt sind, wobei an den Längs- und Querrändern des Sargkörpers (1) im Wesentlichen parallel zum Boden verlaufende Auflagen (14,21) vorgesehen sind, und wobei die Auflagen (21) der Querränder des Sargkörpers (1) in einer gegenüber den Auflagen (14') der Längsränder des Sargkörpers (1) geringeren Höhenlage verlaufen, wobei der Höhenunterschied im Wesentlichen der Materialstärke der Wellpappe entspricht, wobei sich die Auflagen (14') der Längsränder gegen die Längsmittenebene des Sargkörpers (1) zu trapezartig verjüngen, sodass deren Schmalseiten mit den Längs- und Querrändern des Sargkörpers (1) spitze Winkel einschließen, und wobei die Auflagen (14') der Längsränder die Auflagen (21) der Querränder zumindest abschnittsweise überlappen und wobei der Deckel an den Enden von Kopf- und Fußwänden angeordnete Auflagen aufweist, welche an den Auflagen (21) von Kopf- und Fußwänden (9,10) des Sargkörpers (1) abstützbar sind.
Patent AT-512658-B1 (AT)
Title: Sicherheitseinrichtung für Schlösser
Inventor: ENNE REINHARD J ING
IPC: E05B13/00
Filed: 2012-05-10
Granted: 2013-10-15
Abstract: Bei einer Sicherheitseinrichtung für Schlösser mit einer Handhabe (1), welche im Ruhezustand frei drehbar und im Betätigungszustand mit dem Verriegelungsglied des Schlosses kuppelbar ist, ist eine Brems- oder Blockiereinrichtung vorgesehen, die ab einer definierten Anzahl von Umdrehungen der Handhabe (1) in einer Zeiteinheit die weitere Drehbewegung bremst oder blockiert. Die Brems- oder Blockiereinrichtung umfasst ein zwischen einer Freigabeposition und einer Brems- oder Blockierposition verlagerbares Element, das in der Brems- oder Blockierposition mit einem Gegenelement zusammenwirkt, um die weitere Drehbewegung zu bremsen oder zu blockieren. Die Handhabe (1) ist von dem verlagerbaren Element in dessen Freigabeposition mechanisch entkoppelt.
Patent AT-512783-B1 (AT)
Title: Verfahren zum Rollieren einer zylindrischen Bauteilfläche
IPC: B21D1/06
Filed: 2012-05-22
Granted: 2013-11-15
Abstract: Bei einem Verfahren zum Rollieren einer insbesondere zylindrischen Bauteilfläche eines Werkstücks (1) unter Verwendung eines wenigstens ein Wälzelement (3) aufweisenden Rollierwerkzeugs, wird das wenigstens eine Wälzelement (3) durch hydrostatische Beaufschlagung radial nach außen gegen die Bauteilfläche gedrückt und durch Drehen des Rollierwerkzeugs oder des Werkstücks (1) an der Bauteilfläche abrollen gelassen. Das auf Grund der Reibung zwischen dem wenigstens einen Wälzelement (3) und der Bauteilfläche entstehende Drehmoment oder eine das Drehmoment repräsentierende Messgröße wird erfasst und einer Auswertung zugeführt.
Patent AT-508738-B1 (AT)
Title: Mehrzonen-schichtladespeicher
IPC: F24D3/08
Filed: 2010-05-20
Granted: 2012-12-15
Abstract: Bei einem Mehrzonen-Schichtladespeicher für eine Heizungsanlage mit einer Schichtladung, die wenigstens in eine Pufferspeicherzone (3) und eine darüber liegende Warmwasserladungszone (2) unterteilt ist, die Ladungszonen (2, 3) durch eine waagerecht angeordnete durchlässige Trennscheibe (5) voneinander getrennt sind, und einer Heizfläche (4) im Innern des Speicherbehälters (1), die als Kondensator einer Wärmepumpe ausgebildet und in der Pufferladungszone (3) mit Strömungsleitvorrichtungen (6, 71, 72) versehen ist, ist die Heizfläche (4) an eine Wärmequelle (8) angeschlossen und wenigstens im wesentlichen über die gesamte Höhe der Schichtladung reichend angeordnet und sie weist am Eingang einen höheren Wärmeübergang zum Speichermedium als am Ausgang auf und im unteren Pufferladungszonenbereich (3) ist ein Einspritzring (71) und im oberen Pufferladungszonenbereich (3) ist ein Absaugring (72) angeordnet, die an einen Heizkreis (7, 70) angeschlossen sind.
Patent BG-60639-B1 (BG)
Inventor: PIROVSKI LJUBOMIR T
IPC: A61K31/355
Filed: 1993-02-03
Abstract: Препаратът намира приложение при приготвянето на хранителни, диетични и козметични лечебни продукти, по-специално за лечение и профилактика на дислипопротеинемии, исхемична болест на сърцето и мозъка, периферни съдови заболявания, атеросклероза, дерматози, изгаряния, себорея, вирусни инфекции и радиационни поражения, като екопротектор и адаптоген и при производството на фуражни добавки за птици ибозайници. Той съдържа триглицериди на алифатните мастни киселини с 16 до 18 въглеродни атома,   -каротин и -токоферол, като триглицеридите са под формата на екстракт с диетилов етер или хлороформ.                      подадена е декларация за лицензионна готовност съгласно чл. 30 от закона за патентите (зп).
Patent BR-0215355-B1 (BR)
Inventor: VESTRE JAN
IPC: F42D1/10
Filed: 2002-12-20
Abstract: This invention relates to a method for rapid chemical gassing of an emulsion explosive without having toxic nitrogen oxides in the finished emulsion explosive product, when nitrite is used as the gassing component. Urea acts as a gassing accelerator and urea are added in the water lubrication solution or in both the water lubrication solution and in the gassing component. To achieve rapid gassing of an emulsion explosive, the emulsion is prepared at a pH in the range of 0-3, by using an organic acid having at least 3 carbon atoms.
Patent WO-2004047494-B1 (WO)
Title: Bobine de travail a chauffage par induction
Inventor: LARIVE RENE
IPC: H05B6/14
Filed: 2003-11-17
Abstract: L'invention concerne un dispositif de chauffage par induction ou une bobine de travail servant à chauffer un matériau électroconducteur jusqu'à une température désirée. La bobine de travail peut s'utiliser sur un rouleau ou un cylindre de n'importe quel diamètre. La bobine de travail comprend un noyau ouvert en ferrite, qui a la forme d'un U. Un fil est enroulé autour des branches opposées de cet U, de manière à ce que sous l'effet d'excitation une branche devienne le pôle N et l'autre branche devienne le pôle S, et que la polarité alterne en fonction de la polarité du courant d'excitation. Une couche plate rectangulaire sensiblement mince de ferrite peut être attachée aux extrémités de chaque pièce polaire. Chaque couche de ferrite a une longueur suffisante pour recouvrir l'extrémité de fond de chaque branche et une largeur dans la direction d'un axe perpendiculaire à la face du U qui correspond à l'ampleur de l'effet de chauffage de commande désiré.
Patent DE-2631940-B1 (DE)
Title: Chimney cowl with metal tube extending into chimney - has upwards tapered wind deflectors removabley fitted on upwards tapered heat insulating sleeve on tube
Inventor: BASTEN GERT
IPC: F23L17/02
Filed: 1976-07-15
Abstract: The chimney cowl has a metal tube (3) received within the top of the chimney opening so that a heat insulating sleeve (5) around the tube rests on the upper surface of the chimney. The sleeve tapers upwardly and supports removable sheet metal wind deflectors (8) which taper upwardly and deflect wind between them, and between them and the sleeve, upwards to form a chimney updraft. There may be a heat insulting top plate assembly turning the deflected wind and chimney exhaust horizontally.
Patent EE-03341-B1 (EE)
Inventor: KJELL SAND
IPC: B05B7/08
Filed: 1996-09-24
Abstract: A nozzle for feeding a mixt. of thermosetting plastics and hardener from a mixing chamber with separate feed lines has beam channels (14) extending from the chamber with a dia. (b) of 0.5-1.5 mm and axially convergent at an angle (~a) of 70-140 deg  towards a point outside the nozzle. Also claimed is the method of feeding a mixt. through the nozzle, the mixt. having a viscosity of 150-75,000 cP and being discharged under a pressure of 75-100 bar. Each channel exits perpendicular to a respective planar surface (13), with the surfaces at a mutual angle of 70-140 deg , and the channel outlets spaced by 2-5 mm.
Patent WO-0170338-B1 (WO)
Title: Composition de decontamination et ses emulsions
Inventor: FRANKE SIEGFRIED
IPC: A62D101/20
Filed: 2001-03-13
Abstract: L'invention vise à obtenir une composition de décontamination qui soit plus acceptable que les compositions de désintoxication connues du point de vue de la toxicité, qui ait un point d'éclair moins bas que celles-ci et qui, appliquée sous forme de couche sur une surface à décontaminer, recouvre complètement cette surface. A cet effet, la composition de décontamination comprend, outre un agent actif, un sel neutre, un diluant et un émulgateur, également un ou plusieurs acides gras naturels et/ou leurs dérivés dans le diluant.
Patent ES-2080633-B1 (ES)
Title: Sistema de cerradura.
Inventor: PENA SANTACRUZ DOMINGO
IPC: E05B49/02
Filed: 1992-01-27
Granted: 1996-10-16
Abstract: SISTEMA DE CERRADURA. EN EL QUE CADA LLAVE (1) ES UN CIRCUITO ELECTRONICO DIGITAL CON SUS CLAVES GRABADAS EN BITS, CLAVES ESTAS QUE, A TRAVES DEL BOMBIN DE CONEXIONES (2) LLEGA AL CIRCUITO DE CONTROL (3), EN DONDE UN MODULO DE LOGICA Y DECISION CON DIAGRAMA DE TIEMPOS ESTABLECE LA CORRESPONDIENTE COMPARACION ENTRE LA CLAVE DE LA LLAVE (1) Y LA DE LA CERRADURA.
Patent ES-2048669-B1 (ES)
Title: Perfeccionamientos en la construccion de maquinas electronicas de juego.
Inventor: QUETGLAS ARINO MIGUEL ANGEL
IPC: G07F17/32
Filed: 1992-07-31
Granted: 1996-12-16
Abstract: CONSISTE LA PRESENTE PATENTE DE INVENCION EN UNOS PERFECCIONAMIENTOS EN LA CONSTRUCCION DE MAQUINAS ELECTRONICAS DE JUEGO, EN QUE EN LA PARTE DELANTERA DEL CUERPO DE LA MAQUINA HAY UNA BASCULA ELECTRICA DE SUPERFICIE ACOLCHADA, QUE ES LA QUE RECIBE Y MESURA EL ESFUERZO ORIGINADO POR EL IMPACTO DEL GOLPE PROPINADO DIRECTAMENTE POR EL JUGADOR CONTRA DICHA PLACA, Y LA BASCULA ESTA CONEXIONADA A UN CONVERSOR ANALOGICO DIGITAL MUY RAPIDO, Y ESTE A UN INTERFACE DE CAPTACION Y ALMACENAMIENTO DE LOS DATOS A CONTABILIZAR POR EL MODULO CONTABILIZADOR Y DESDE EL MODULO DE CAPTACION Y ALMACENAMIENTO DE DATOS A CONTABILIZAR PARTE UN "BUS" QUE CONECTA CON UN CIRCUITO DE INTERFACE CON TV Y DE ESTE SE CONECTA UN MODULO DE LUZ Y SONIDO Y A UN MAGNETOSCOPIO O VIDEOREPRODUCTOR QUE PERMITE VISUALIZAR POR LA PANTALLA DE TV, A VOLUNTAD DE LA CPU Y SEGUN PROGRAMACION REALIZADA EN SUS MEMORIAS Y DE ACUERDO CON LAS FASES DEL JUEGO Y PUNTUACION ALCANZADA POR EL JUGADOR, UNA PELICULA EN VIDEO DE CORTA DURACION.
Patent ES-2049652-B1 (ES)
Title: Procedimiento para la preparacion de un acido quinolin carboxilico.
Inventor: PALOMO COLL ALBERTO
IPC: A61K31/47
Filed: 1992-09-16
Granted: 1994-10-01
Abstract: PROCEDIMIENTO PARA LA PREPARACION DE UN ACIDO QUINOLIN CARBOXILICO, DE FORMULA I QUE COMPRENDE LA REACCION DE LA 2,3,4-TRIFLUORANILINA CON UN ALCOXIMETILENMALONATO DE DIALQUILO DE FORMULA III FORMULA (R = ME O ET) EN PRESENCIA DE TETRAETILENGLICOLDIMETILETER; LA REACCION PROPORCIONA 6,7,8-TRIFLUOR-1,4-DIHIDRO-4-OXOQUINOLIN-3-CARBOXILATO DE METILO O ETILO, QUE SE HACE REACCIONAR CON UN COMPUESTO DE FORMULA V FORMULA (X ES UN GRUPO SALIENTE), EN PRESENCIA DE CATALIZADORES Y DE UNA BASE, OBTENIENDOSE, DESPUES DE HIDROLISIS BASICA, UN COMPUESTO DE FORMULA VI. FORMULA QUE SE CICLA Y CONDUCE AL COMPUESTO DE FORMULA I. ESTE COMPUESTO ES UN VALUOSO INTERMEDIO PARA LA OBTENCION DE ANTIBIOTICOS (OFLOXACINA).