baber/WOPTO huggingface dataset:
Patent TW-202323286-A (TW)
Title: anti-EphA4 antibody
Inventor: KAWAKATSU TOMOMI
IPC: C07K16/18
Filed: 2022-11-09
Abstract: To provide an antibody that can bind specifically to EphA4 and detect EphA4 at high detection sensitivity and a method and a kit for detecting or quantifying EphA4 characterized by the antibody. Provided are an antibody having a specific heavy chain CDR sequence and light chain CDR sequence and an antigen-binding fragment thereof, and a method and kit characterized by the same. Specifically, an antibody according to the present invention or antigen-binding fragment thereof includes: (a) a heavy chain including a heavy chain CDR1 comprising an amino acid sequence represented by SEQ ID NO: 52, a heavy chain CDR2 comprising an amino acid sequence represented by SEQ ID NO: 53, and a heavy chain CDR3 comprising an amino acid sequence represented by SEQ ID NO: 54, and a light chain including a light chain CDR1 comprising an amino acid sequence represented by SEQ ID NO: 55, a light chain CDR2 comprising an amino acid sequence represented by SEQ ID NO: 56, and a light chain CDR3 comprising an amino acid sequence represented by SEQ ID NO: 57; (b) a heavy chain including a heavy chain CDR1 comprising an amino acid sequence represented by SEQ ID NO: 64, a heavy chain CDR2 comprising an amino acid sequence represented by SEQ ID NO: 65, and a heavy chain CDR3 comprising an amino acid sequence represented by SEQ ID NO: 66, and a light chain including a light chain CDR1 comprising an amino acid sequence represented by SEQ ID NO: 67, a light chain CDR2 comprising an amino acid sequence represented by SEQ ID NO: 68, and a light chain CDR3 comprising an amino acid sequence represented by SEQ ID NO: 69; or (c) a heaving chain including a heavy chain CDR1 comprising an amino acid sequence represented by SEQ ID NO: 40, a heavy chain CDR2 comprising an amino acid sequence represented by SEQ ID NO: 41, and a heavy chain CDR3 comprising an amino acid sequence represented by SEQ ID NO: 42, and a light chain including a light chain CDR1 comprising an amino acid sequence represented by SEQ ID NO: 43, a light chain CDR2 comprising an amino acid sequence represented by SEQ ID NO: 44, and a light chain CDR3 comprising an amino acid sequence represented by SEQ ID NO: 45.
Patent TW-202324864-A (TW)
Title: Semiconductor laser and method for producing semiconductor laser
Inventor: NAKAMURA NAOKI
IPC: H01S5/042
Filed: 2022-11-15
Abstract: A semiconductor laser (100) according to the present invention is provided with: a ridge structure (16) that is formed on an n-type semiconductor substrate (1); and an embedded layer (13) that is embedded so as to cover the both sides of the ridge structure (16), the both sides being opposite to each other in a direction that is perpendicular to the extending direction of the ridge structure (16). The ridge structure (16) comprises an n-type clad layer (4), an active layer (5) and a p-type clad layer (6), which are sequentially formed from the n-type semiconductor substrate (1) side. The embedded layer (13) has a semi-insulating layer (8) and a p-type semiconductor layer (7b) that is in contact with both lateral surfaces of the p-type clad layer (6) and the active layer (5) of the ridge structure (16); and the p-type semiconductor layer (7b) is not in contact with the n-type clad layer (4) of the ridge structure (16).
Patent TW-202330482-A (TW)
Title: Method and system for preparing diphenylamine and phenothiazine from aniline
Inventor: Qi wen-bo
IPC: C07D279/20
Filed: 2022-12-01
Abstract: The present invention relates to the technical field of organic synthesis. Disclosed are a method and system for preparing diphenylamine and phenothiazine from aniline. The method comprises: reacting an aniline raw material; carrying out gas-liquid separation on an obtained reaction mixture containing diphenylamine, and obtaining a first liquid product and a first gas product; separating the first liquid product, and obtaining an aniline reclaimed material and a diphenylamine product; reacting part of the obtained diphenylamine product; carrying out gas-liquid separation on an obtained reaction mixture containing phenothiazine, obtaining a second liquid product and a second gas product, and separating a phenothiazine product from the second liquid product. In the present invention, by coupling a diphenylamine synthesis process and a phenothiazine synthesis process, the heat of the two processes can be coupled, which greatly reduces the energy consumption of the coupled processes. In addition, the output of the two products can be reasonably allocated according to market conditions, and the product purity of diphenylamine can be flexibly adjusted, thereby optimizing the product structure.
Patent TW-202311869-A (TW)
Inventor: AOKI YASUO
IPC: G03F7/20
Filed: 2016-03-31
Abstract: This exposure apparatus, which irradiates a substrate (P) with illumination light via a projection optical system, and relatively drives the substrate (P) with respect to the illumination light, to respectively scan and expose a plurality of areas of the glass substrate (P), is provided with: a substrate holder (68) which levitates and supports a first area of the substrate (P); a substrate carrier (70) which holds the glass substrate (P) levitated and supported by the substrate holder (68); an X coarse movement stage (40) for driving the substrate holder (68); X voice coil motors (84x) and Y voice coil motors (84y) which drive the substrate carrier (70); and a control device which controls the X coarse movement stage (40), the X voice coil motors (84x), and the like such that the substrate holder (68) and the substrate carrier (70) are respectively driven during scanning and exposure. Accordingly, an exposure apparatus having improved object position controllability can be provided.
Patent UA-38675-A (UA)
Title: Спосіб виготовлення фітокомпозицій пролонгованої дії з сорбційною активністю і фітокомпозиції, одержані вищезазначеним способом
Filed: 2000-08-15
Abstract: Винахід відноситься до фармацевтичних способів одержання лікарських засобів. Декілька фітопрепаратів, підібраних для досягнення терапевтичного ефекту рівномірно змішуються з високодисперсним пірогенним кремнеземом, який має питому поверхню не менше 200 м2/г. Перед змішуванням повинен бути спеціально підготовлений - знаходитись в реакторі у завислому високодисперсному стані, а фітопрепарати, інколи фітопрепарати з лікарськими чи дезинфікуючими, чи бактерицидними препаратами вводяться при постійній зміні зон взаємодії з носієм за спеціальною схемою для кожної композиції - або почергово, або в суміші, що готується перед введенням або в момент введення в сумарному ваговому відношенні від 1:6 до 1:20.
Patent UA-47757-A (UA)
Title: Absorptive-diffusive cooling machine
Inventor: TITLOV OLEKSANDR SERHIIOVYCH
Filed: 2001-09-04
Abstract: An absorptive-diffusive cooling machine contains a dephlegmator, having vertical lowering and lifting channels, connected one to another below a strong water ammonium solution by a horizontal rectifier, a thermal siphon, and a heat exchanger for liquid, made of a 'tube in tube' type. And the external channel of the liquid heat exchanger is connected to the dephlegmator lifting channel, and to the absorber lower part, and the internal channel of the liquid heat exchanger is passing through the horizontal rectifier and the vertical lowering channel and connects the pumping thermal siphon to the upper part of the absorber.
Patent UA-53147-A (UA)
Title: Method for treating metabolic cardiomyopathy in children with vegetative dysfunction
Filed: 2002-03-25
Abstract: The method for treating the metabolic cardiomyopathy in children with the vegetative dysfunction provides for employing Aurocard taken per os thrice a day at a dose of 10 drops. The drug is taken 30 minutes before the meals or after the meals for 6 weeks.
Patent UA-53283-A (UA)
Title: A process for making the filtering ceramics articles with a slit shaped cavity
Filed: 2002-04-19
Abstract: A process for making the filtering ceramics articles with a slit shape cavity, preferably the filtering elements of the disc filters includes the following operations: preparation of a molding sand of porous ceramics, articles pieces shaping, heat and mechanical treatment thereof. The article is made from two pieces in the form of a half-article defining a peripheral and central areas in each of them. In addition, in the central area a recess is shaped, the height wherein is equal to a half of a slit shape cavity height. An adhesive composition is applied to the peripheral area, whereupon two pieces are assembled in one article having recesses one towards another, and the heat treatment is carried out.
Patent UA-56429-A (UA)
Title: appliance for cleaning the inner surface of pipeline from sediments
Inventor: BRIUKHANOV OLEKSANDR MYKHAILOVYCH
Filed: 2002-04-22
Abstract: An appliance for cleaning the inner surface of a pipeline from sediments has a hollow housing with openings, where main and additional electrodes are installed. Openings provided in the wall of the housing are arranged in pairs, symmetrically with respect to the central axis of the housing, and are made as slots, at that the first and the last pairs of the slots are in the planes going through the middles of the inter-electrode gaps.
Patent UA-54872-A (UA)
Title: Endoscope with function of express diagnosis of origin and level of bacterial contamination in mucosa of upper respiratory ways
Inventor: AVRUNIN OLEH HRYHOROVYCH
Filed: 2002-04-29
Abstract: The endoscope with the function of the express diagnosis of the origin and the level of the bacterial contamination in the mucosa of the upper respiratory ways consists of the flexible tube comprising the first light-guide connected to the illuminating unit with the adjustable light source and the second light-guide connected to the recording unit comprising the digital photo camera. The device also comprises the control subsystem with computer and interface. The interface provides for two-way connection with the digital photo camera of the recording unit and the adjustable light source of the illuminating unit.
Patent AP-1445-A (AP)
Title: Substituted 4-amino-thiazol-2-yl compounds as CDKs inhibitors.
Inventor: CHONG WESLEY K M
IPC: C07D521/00
Filed: 1998-10-27
Granted: 2005-07-10
Abstract: The invention is directed to aminothiazole compounds of formula (I) wherein R1 is a substituted or unsubstituted group selected from: C1-6alkyl; C1-6alkylkenyl; C1-6alkylnyl; C1-6alkylkoxyl; C1-6alcohol; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl; carbonyl; ether; (C1-6alkyl)-carbonyl; (C1-6alkyl)-aryl; (C1-6alkyl)-cycloalkyl; (C1-6alkyl)-( C1-6alkylkoxyl); aryl-( C1-6alkylkoxyl); thioether; thiol; and sulfonyl; wherein when R1 is substituted, each substituent independently is a halogen; haloalkyl; C1-6alkyl; C1-6alkylkenyl; C1-6alkynyl; hydroxyl; C1-6alkyl; amino; nitro; thiol; thioether; imine; cyano; amido; phosphonato; phosphine; carboxyl; thiocarbonyl; sulfonyl; sulfonamide; ketone; aldehyde; ester; oxygen; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl; or carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl; and R2 is a carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, ring structure having a substituent at the position adjacent to the point of attachment, which ring structure is optionally further substituted, where each substituent of R2 independently is a halogen; haloalkyl; C1-6alkyl; C1-6alkenyl; C1-6alkyl; hydroxyl; C1-6alkoxy; amino; nitro; thiol; thioether; imine; cyano; amido; phosphonato; phosphine; carboxyl; thiocarbonyl; sulfonyl; sulfonamide; ketone; aldehyde; ester; oxygen; carbocyclic or heterocyclic monocyclic or fused or non-fused polycyclic, cycloalkyl; or carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl; or a pharmaceutically acceptable salt of a compound of formula (I), or a prodrug or pharmaceutically active metabolite of a compound of formula (I)or pharmaceutically acceptable salt thereof, for inhibiting cyclin-dependent kinases (CDKs), such as CDK1, CDK2, CDK4 and CDK6. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds and to methods of treating malignancies and other disorders by administering effective amounts of such compounds.
Patent AP-1697-A (AP)
Title: Azabicycloalkanes as CCR5 modulators.
Inventor: ARMOUR DUNCAN ROBERT
IPC: A61K31/439
Filed: 1999-12-23
Granted: 2006-12-22
Abstract: Compounds of the formula (I) [Region a]- [Region b]- [Region y]- [Region e] which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and methods of treatment using these compounds.
Patent AP-1251-A (AP)
Title: Illudin analogues useful as antitumor agents.
Inventor: MCMORRIS TREVOR
IPC: A61K31/36
Filed: 1997-07-14
Granted: 2004-02-27
Abstract: The present invetion provides illudin analogs of general formula (i)where r1 is (ch2)n-x-y or h; n is 0 to 4; x is o or s or n or absent; and y is an optionally substituted (c1-c8)alkyl, (c6-c10)aryl, (c6-c10 aryl(c1-c4)alkyl or cyclo(c3-c6)alkyloptionally comprising one or more heteroatoms; a monosaccharide, an amino acid residue, or h when n is 2-4;r2 is absent; or r1 and r2 together comprise a 5-7 membered cyclic ring; r3 is (c1-c4)alkyl or h; r4 is h, sch2co2(c1-c4)alkyl,o-(c5-c12)aryl or -s-(c5-c12)aryl; r5 is h; oh or absent; r6 is c1-c4)alkyl or absent; r7 is oh or osi((c1-c4)alkyl)3;or r6 and r7 together are ethylenedioxy; r8 is optionally substituted (c1-c4)alkyl; and the bonds represented by----- are individually present or absent. The invention furher provided dimers comprising analogs for formula (i)
Patent DO-P2018000257-A (DO)
Title: Piridinas sustituidas con heteroarilo y métodos de uso
Inventor: XUEQING WANG
IPC: C07D417/14
Filed: 2018-11-26
Abstract: La invención divulga compuestos de Fórmula I, donde X1, X2, R1, y R2 son como se definen en el presente documento. La presente invención se refiere a compuestos y su uso en el tratamiento de la fibrosis quística, métodos para su producción, composiciones farmacéuticas que los contienen y métodos de tratamiento de la fibrosis quística administrando un compuesto de la invención.
Patent EC-SP12011593-A (EC)
Title: Análogos de glucagón acilados
Inventor: RIBER DITTE
IPC: C07K14/605
Filed: 2012-01-11
Abstract: La invención proporciona materiales y procedimientos para promover la pérdida de peso o prevenir el aumento de peso, y en el tratamiento de diabetes y trastornos metabólicos asociados. En particular, la invención proporciona péptidos de análogos de glucagón acilados novedosos eficaces en tales procedimientos. Los péptidos pueden mediar en su efecto teniendo un aumento de la selectividad por el receptor de GLP-1 en comparación con glucagón humano.
Patent GB-189702399-A (GB)
Title: Improvements in Machines for Bending Metal Bars the same being applicable for use in the Manufacture of Laminated Springs.
Inventor: LONGSDON HENRY CROFTS
Filed: 1897-01-29
Granted: 1897-12-04
Abstract: 2399. Longsdon, H. C., and Wilkinson, F. Jan. 29. Bending.-Machines for bending bars, more especially for use in making laminated springs, are arranged so that they can be operated by a driving-belt from a prime mover or rotary shaft and can be easily put into or out of action. The bars are bent between the usual dies a, b, the moving die a being attached to a slide h advanced by a cam c on the shaft d driven by gearing from a shaft w provided with belt pulleys. The cam c acts on a roller n on an arm m pivoted to the slide h and moved into the horizontal position by the hand-lever o. At the end of the advance of the slide h, the arm m rises to a vertical position and the slide h is returned by weighted chains t<1>. The slide h may be reciprocated from the shaft d by crank or eccentric mechanism, the driving-mechanism being connected by treadle mechanism disengaging one of the wheels from its shaft.
Patent GB-189710060-A (GB)
Title: Improvements in connection with Umbrellas and Walking Sticks.
Inventor: HUGENDUBEL ERNST
Filed: 1897-04-22
Granted: 1897-06-12
Abstract: 10,060. Hugendubel, E. April 22. Umbrellas and walking- s t i c k s combined.-The handle d, d' is capable of axial rotation on the umbrella stick b, and carries an internally screw-threaded sleeve f, which can engage a bush g<1>. A second bush, with a blocked end, is made to fit the ferrule end of the umbrella stick, and the two are connected by a case or sheath g, so that, when the umbrella is placed inside and the handle screwed on, an apparently solid stick is formed. When the umbrella is required, the sheath is removed and carried separately. A disc b<1>, carrying a pin e in a socket b<2>, is secured to the stick b, so that, when the umbrella is in use, the pin falls into one of a number of holes e<1> in the handle and prevents relative motion of the latter and the stick. A bayonet-joint or other suitable connection may be used for joining the sleeve f to the bush g<1>.
Patent GB-189711647-A (GB)
Title: Improvements in and relating to the Pedals and Pedal Attachments of Cycles.
Inventor: WEBSTER ALFRED HENRY
Filed: 1897-05-11
Granted: 1898-04-23
Abstract: 11,647. Webster, A. H. May 11. Pedals are constructed with inner tubes A carrying the bearing-cones B, through which tubes are passed spindles D preferably formed of soft steel. One end of each spindle is provided with a conical or cylindrical head E or E<2> which engages a suitably-shaped recess in the end of the crank H. To fix the pedal to the crank, the pin D is first removed from the pedal, and then passed through the eye of the crank and fixed by the nut F. The pedal is then passed on to the pin, and secured in position by a set screw G or other means.
Patent GB-189713730-A (GB)
Title: Improvements in Pneumatic Tyres for Road Vehicles.
Inventor: MARCH OCTAVIUS
Filed: 1897-06-03
Granted: 1898-04-09
Abstract: 13,730. March, O. June 3. Tyres, pneumatic, attaching to rim. The thickened edges b of the outer cover a are secured between the rim r and the in-turned edges d of a false rim c. This false rim preferably consists of a circumferential spring band, the overlapping ends of which are provided with slots through which the inflating-valve may be passed, so that screwing up the valve fixes the band. If desired, the band may be butt-jointed or endless. In the case of flat rims, saddle-shaped clips fare employed to prevent the tyre from slipping off the rim.
Patent GB-189718285-A (GB)
Title: An Improved Devicef for Retaining Clothes and like Materials Upon a Line or Wire for Laundry and other Purposes.
Inventor: HUSSEY GEORGE FREDERIC
Filed: 1897-08-06
Granted: 1897-09-25
Abstract: 18,285. Hussey, G. F. Aug. 6. Clothes-pegs.-A device for retaining clothes and other materials upon a line or wire consists of a block of wood A having a space B cut therein, with wider portions a for the reception of the line b. The device is secured in position by means of a tapered wooden peg C passing through a hote in the block A, or by other means.
Patent GB-189719739-A (GB)
Title: Improved Devices for Preventing the Inward and Outward Treading of Boots and Shoes.
Inventor: DAVIDSON FANNY
Filed: 1897-08-27
Granted: 1898-08-20
Abstract: 19,739. Davidson, F. Aug. 27. Stiffeners.-To prevent the treading over of boots and shoes, an additional metal stiffener of the form shown in Fig. 1 is placed at each side in the position shown in Fig. 2 between the lining and usual stiffener. The part b is placed between the midsole and the outer sole, and secured by nails or the like through perforations b<1>.
Patent GB-189720035-A (GB)
Title: Improved Printing Type.
Inventor: BECK WILLIAM HENRY
Filed: 1897-08-31
Granted: 1897-11-20
Abstract: 20,035. Beck, W. H., [Johnson, L. K, and Low, A. A.]. Aug. 31. Type.-Relates to the method of type setting in which groups of types forming words or syllables &c. are forwarded simultaneously from containing- channels for removal by the fingers of the operator. The types are provided with distributing-nicks, such that the types forming any one word or group have differently-placed nicks from the types used in any other group, but the nicks of the types forming any word or group are the same. Thus the types of a letter or character would be nicked differently for each group in which it is used and for use separately. In distributing such types by machinery, the types of a group would generally follow each other and would be distributed by the feelers into the same receiver. Fig. 1 shows a plan and Fig. 2 an edge view of a number of word groups A with spaces S. The nicks are shown at a, Fig. 2.
Patent GB-189722266-A (GB)
Title: An Appliance for Use in Teaching Arithmetic.
Inventor: COTMAN FREDERICK JOHN
Filed: 1897-09-28
Granted: 1898-09-28
Abstract: 22,266. Cotman, F. J., and Walker, W. G. Sept. 28. Arithmetic, teaching. -Fig. 2 shows a sectional side view of the apparatus. The frame A carries horizontal wires B, on which are mounted a series of rotatable cubes C. Figures are marked on the faces of the cubes C. The movable backboard F, attached to the frame D by suitable links, rests against the backs of the cubes C and holds them in place. The results of the addition or subtraction of the numbers shown are written on the lower surface of the frame D.
Patent GB-189730487-A (GB)
Title: Improvements in Apparatus used in the Manufacture of Cycle Wheels, and other Circular or Annular Articles.
Inventor: CUNLIFFE WILLIAM
Filed: 1897-12-24
Granted: 1898-12-23
Abstract: 30,487. Cunliffe, W., and Holt, D. W. Dec. 24. Nuts, screwing into place.-Relates to a multiple tool for simultaneously drilling a number of holes in cycle wheel rims or other annular articles or for tightening the spokes. The spindles b, to the ends of which drills or tightening-devices can be fitted, are arranged radially all round a frame a and rotate with, but can slide through, bevel pinions c driven by crown teeth on a worm-wheel n. The worm-wheel receives motion from a worm o turned by hand or other power. To feed the spindles towards the work, they are surrounded by collars f taking over grooves in the spindles and having projections g each fitted with two antifriction bowls h. The bowls rest respectively in a radial slot in the casing a and an inclined slot in a toothed ring l, concentric with the frame, which can be rotated by a pinion m. On turning the thumb-piece m*, all the spindles bare simultaneously moved in towards the centre.