Patent SG-11201903954W-A (SG)
Title: Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder
Inventor: PESTEL SABINE
IPC: A61K38/37
Filed: 2017-11-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 17 May 2018 (17.05.2018) WIPO I PCT D IV SID o III uo IIIII Ho mil Imo VII IE (10) International Publication Number WO 2018/087271 Al (51) International Patent Classification: A61K 38/36 (2006.01) A61P 7/04 (2006.01) A61K 38/37 (2006.01) A61K 36/36 (2006.01) C07K 14/755 (2006.01) A61K 36/37 (2006.01) (21) International Application Number: PCT/EP2017/078840 (22) International Filing Date: 10 November 2017 (10.11.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16198497.6 11 November 2016 (11.11.2016) EP (71) Applicant: CSL BEHRING RECOMBINANT FACILI- TY AG [CH/CH]; Wankdorfstrasse 10, 3014 Bern (CH). (72) Inventors: PESTEL, Sabine; Stuempelstal 19, 35041 Mar- burg (DE). RAQUET, Elmar; Wilhelm-Tischbein-Strasse 12, 35066 Frankenberg (DE). WEIMER, Thomas; Richard-Wagner-Strasse 8, 35075 Gladenbach (DE). (74) Agent: LUDWIG, Holger et al.; Emil-von-Behring- Strasse 76, 35041 Marburg (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) N (54) Title: TRUNCATED VON WILLEBRAND FACTOR POLYPEPTIDES FOR EXTRAVASCULAR ADMINISTRATION IN el THE TREATMENT OR PROPHYLAXIS OF A BLOOD COAGULATION DISORDER *t (57) : The invention pertains to a recombinant polypeptide comprising a truncated von Willebrand Factor (VWF) for use in the treatment or prophylaxis of a blood coagulation disorder, said treatment or prophylaxis comprising administering the recombinant polypeptide and a Factor VIII protein (FVIII) extravascular to a subject having a blood coagulation disorder, wherein said recombinant 1-1 polypeptide is capable of binding to said FVIII, and wherein the molar ratio of the recombinant polypeptide to be administered to the f'1 FVIII to be administered is higher than 50.