baber/WOPTO huggingface dataset:
Patent FI-891200-A (FI)
Inventor: KHANNA ISH K
IPC: A61K31/435
Filed: 1989-03-14
Abstract: This invention relates to novel substituted imidazopyridine dervatives having the following formula <CHEM>  or a pharmaceuticaly acceptable acid addition salt: wherein R1 and R2      are each independently selected from hydrogen; straight or branched chain alkyl of 1 to 15 carbon atoms; cycloalkyl having 3 to 8 carbon atoms; substituted cycloalkyl which can be substituted one or more by alkyl of 1 to 6 carbon atoms; bicycloalkyl having 3 to 8 carbon atoms in each ring; heterocyclicalkyl having 4 to 8 carbon atoms which can be optionally substituted by alkyl of 1 to 6 carbon atoms; heteroaromatic having 5 or 6 carbon atoms which can be optionally substituted by alkyl of 1 to 6 carbon atoms; phenyl; substituted phenyl which can be substituted one or more by a group independently selected from alkyl of 1 to 6 carbon atoms or halogen; straight or branched alkenyl having 3 to 15 carbon atoms with the proviso that the double bond of the alkenyl group cannot be adjacent to the nitrogen; cycloalkenyl having 5 to 8 carbon atoms with the proviso that the double bond cannot be adjacent to the nitrogen; R1 and R2 cannot both be hydrogen Y      is phenyl or phenyl substituted once or more than at one or more of the 2, 3, 5 or 6 position of the phenyl ring by substituents independently selected from the group consisting of alkoxy wherein the alkyl is 1 to 6 carbon atoms; halogen wherein the halogen is selected from bromo, fluoro, or chloro; straight or brnached chain alkyl having 1 to 6 carbon atoms; substituted straight or branched chain alkyl which can be substituted one or more by halogen; thioalkyl wherein the alkyl is 1 to 6 carbon atoms; alkoxyalkyl wherein the alkyl groups are each 1 to 6 carbon atoms; hydroxyalkyl wherein the alkyl is 1 to 6 carbon atoms; alkylthioalkyl wherein the alkyl group are each 1 to 6 carbon atoms; cyano; mercaptoalkyl wherein the alkyl is 1 to 6 carbon atoms; hydroxy; amino; alkylamino wherein the alkyl group are each 1 to 6 carbon atoms; and dialkylamino wherein the alkyl group are each 1 to 6 carbon atoms.  n      is an integer of 1 to 5. R3      is a group substituted at one or more of the 4, 6, or 7 positions of the pyridine ring said group being independently selected from hydrogen; alkyl of 1 to 6 carbon atoms; halogen wherein the halogen is selected from bromo, fluoro or chloro; alkoxy wherein the alkyl is 1 to 6 carbon atoms.  R4      is hydrogen or alkyl of 1 to 6 carbon atoms. useful in the treatment of diseases or disorders mediated by platelet-activating factor. This invention relates to pharmaceutical compositions of such substituted imidazopyridines.
Patent FI-892845-A (FI)
Inventor: INGEMANN OLE
IPC: B65B7/28
Filed: 1989-06-09
Abstract: The invention relates to a method and a device for sealing a container 10 by means of a wafer 20. The container incorporates one or more connecting members 14,16, which are suitable for seal-tight connection to the wafer, in a marginal region 21 thereof, by means of a joint 12, for example a weld joint. The wafer is secured against a contact surface 32 of a holding member so as to be moved by the holding member into contact in its marginal region 21 with any one of the connecting members 14,16. Whilst bearing contact is maintained against the holding member, the wafer is connected by a fastening member 50, in sealing arrangement in its marginal region, to any of the connecting members, this by virtue of an energy supply provided by the fastening member to the marginal region, whereupon the joint 12 is formed. As a result of the invention, a previously cut-to-shape wafer can be fixed in sealing arrangement to the mouth part of the container. Containers housing warm filler product can also be sealed, since in certain embodiments the holding member is cooled by means of cooling ducts 33. The holding member cools the wafer and prevents it being deformed due to the heating which would otherwise be induced by the proximity to warm filler product. <IMAGE>
Patent FI-896215-A (FI)
Inventor: AHOPELTO ERKKI
IPC: E04B1/16
Filed: 1989-12-22
Abstract: The invention concerns concrete shuttering which remains on site after casting. The shuttering 10 comprises at least two shuttering sections 13,14,15 and a support wire or wires 11,12 which are fastened from the joints 20 between the shuttering sections 13,14,15. The invention also considers a procedure for producing concrete shuttering, whereby support wires 11 are placed in the joints 20 of the shuttering sections 13 in the first layer of the shuttering 10, which wires run in a first direction at a distance from each other, and the shuttering sections 13 are joined together. In the joints 20 between the shuttering sections 13 in the first layer and the shuttering sections 14 in the second layer, support wires 12 are placed which run in another direction at a distance from each other, while the shuttering sections 14 in the second layer of shuttering 10 are connected to the shuttering sections 13 of the first layer. Stacking of the shuttering layers continues until the required finished shuttering 10 is achieved. <IMAGE>
Patent FI-901218-A (FI)
Inventor: LEHTONEN PAAVO
IPC: B32B7/02
Filed: 1990-03-12
Abstract: The invention relates to a packaging material comprising a layer which removes oxygen from a package by an enzyme reaction. This packaging material comprises preferably a layer which will be on the outside of the package and is substantially impermeable to gas, and a layer which will be on the inside of the package and is permeable to gas but impermeable to liquid, and a layer therebetween containing an oxygen removing enzyme, such as glucose oxidase, dissolved in a liquid phase, a substrate of said enzyme and optionally an insoluble filler. The invention relates further to a method of producing a packaging material of this kind, whereby a composition containing an oxygen removing enzyme is applied on a plastic film and said film is laminated together with another plastic film in such a manner that the layer containing the oxygen removing enzyme is sandwiched between the plastic films.
Patent FI-942159-A (FI)
Inventor: MERCE-VIDAL RAMON
IPC: A61P25/20
Filed: 1994-05-10
Abstract: The present invention relates to a process for the preparation of 2-{4-[4-(4-chloro-1-pyrazolyl)butyl]-1-piperazinyl}pyrimidine (Lesopitron) of formula I: <IMAGE> characterised in that the reaction between 2-(1-piperazinyl)pyrimidine, 4-chloropyrazole and the carbon chain of formula (III) <IMAGE> in which X and Y, which are identical or different, represent an appropriate leaving group, is carried out in a single step in an appropriate solvent.
Patent FI-942767-A (FI)
Inventor: QUALLICH GEORGE J
IPC: C07C309/66
Filed: 1994-06-10
Abstract: A novel multi-step process for preparing the (4S &cir& _-enantiomer of 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone in a highly-optically pure form is disclosed. The process involves (1) first esterifying 4-(3,4-dichlorophenyl)-4-ketobutanoic acid with isopropylene or isobutylene to form the corresponding isopropyl or t &cir& _e &cir& _r &cir& _t &cir& _.-butyl 4-(3,4-dichlorophenyl)-4-ketobutanoate; (2) then reducing the ketobutanoic acid ester obtained in the first step with an asymmetric carbonyl reducing agent to form the corresponding chiral isopropyl or t &cir& _e &cir& _r &cir& _t &cir& _.-butyl 4-(3,4-dichlorophenyl)-(4R &cir& _)-hydroxybutanoate; (3) then sulfonylating the (4R &cir& _)-hydroxybutanoic acid ester with methanesulfonyl, benzenesulfonyl or p &cir& _-toluenesulfonyl chloride or bromide in the presence of a standard base to yield the corresponding isopropyl or t &cir& _e &cir& _r &cir& _t &cir& _.-butyl 4-(3,4-dichlorophenyl)-(4R &cir& _)-sulfonyloxybutanoate; (4) next subjecting the 4-sulfonyloxybutanoic acid ester obtained in the third step to a copper-coupling reaction with dilithium diphenyl(cyano)cuprate of the formula  PHI 2Cu(CN)Li2 to effect a stereochemical displacement of the organic (4R &cir& _)-sulfonyloxy group of the (4R &cir& _)-sulfonyloxybutanoic acid ester by the phenyl group of the dilithium diphenylcuprate reagent and so selectively form the corresponding isopropyl or t &cir& _e &cir& _r &cir& _t &cir& _.-butyl 4-(3,4-dichlorophenyl)-(4R &cir& _)-phenylbutanoate, and (5) thereafter cyclizing the stereospecific (4R &cir& _)-phenylated n-butanoic acid ester in the presence of a protic or Lewis acid catalyst to finally yield the desired (4S &cir& _)-4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone compound in a highly-optically pure form. The latter compound, which is a novel (4S &cir& _)-enantiomer per se, has utility as an intermediate that ultimately leads to pure c &cir& _i &cir& _s &cir& _-(1S &cir& _)(4S &cir& _)N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine (sertraline), which is a known antidepressant agent. The aforementioned isopropyl and t &cir& _e &cir& _r &cir& _t &cir& _.-butyl esters of 4-(3,4-dichlorophenyl)-(4R &cir& _)-hydroxybutanoic acid, as well as their corresponding (4R &cir& _)-methanesulfonyl, (4R &cir& _)-benzenesulfonyl and (4R &cir& _)-p &cir& _-toluenesulfonyl derivatives, are also novel compounds, as are the aforementioned isopropyl and t &cir& _e &cir& _r &cir& _t &cir& _.-butyl esters of 4-(3,4-dichlorophenyl)-(4R &cir& _)-phenylbutanoic acid as well as the aforesaid acid per se. These novel chiral compounds are all useful as key intermediates in the overall process of the present invention.
Patent FI-943626-A (FI)
Inventor: DAVIS ALAN ROBERT
IPC: A61K/
Filed: 1994-08-04
Abstract: This invention provides a method of producing antibodies or cell mediated immunity to an infectious organism in a warm blooded mammal which comprises administering to said warm blooded mammal intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity.
Patent FI-944279-A (FI)
Inventor: FREDERIKSEN WILMAR FRIIS
IPC: A23L27/40
Filed: 1994-09-15
Abstract: PCT No. PCT/DK93/00100 Sec. 371 Date Sep. 16, 1994 Sec. 102(e) Date Sep. 16, 1994 PCT Filed Mar. 18, 1993 PCT Pub. No. WO93/18668 PCT Pub. Date Sep. 30, 1993A salt product comprising particles of NaCl, K/Mg-double salts and optionally KCl homogeneously distributed throughout each particle and having a molar ratio of K to Mg>/=1. The product may be obtained from an aqueous salt mixture, preferably a solution containing the desired proportion of salt ions and having a water content of 50 to 90% by weight by subjecting the aqueous salt mixture to instant drying at a temperature of 70 DEG  to 200 DEG  C. for a period of 1 to 60 seconds to obtain a dry product. The product is usable as a low sodium substitution for common salt in connection with the preparation of food, beverages or pharmaceutical products and/or as a preservative or water binding agent.
Patent FI-953478-A (FI)
Inventor: PAYNE JOHN DAVID
IPC: C07D275/04
Filed: 1995-07-18
Abstract: PCT No. PCT/GB94/00100 Sec. 371 Date Jul. 19, 1995 Sec. 102(e) Date Jul. 19, 1995 PCT Filed Jan. 19, 1994 PCT Pub. No. WO94/16564 PCT Pub. Date Aug. 4, 1994Stable composition of 1,2-benzisothiazolin-3-one (BIT) in dipropylene glycol having lower pH and lower viscosity than known compositions. The BIT is present as an alkali metal salt obtained by reacting 0.75 to 1.07 moles alkali metal hydroxide with one mole BIT.
Patent FI-965046-A (FI)
Inventor: HAUTALA JOUKO
IPC: D21B1/18
Filed: 1996-12-16
Abstract: PCT No. PCT/FI97/00781 Sec. 371 Date Jul. 22, 1999 Sec. 102(e) Date Jul. 22, 1999 PCT Filed Dec. 12, 1997 PCT Pub. No. WO98/27266 PCT Pub. Date Jun. 25, 1998An arrangement for providing continuous grinding in a pulp grinder comprising a feed chute and a piston in the feed chute moving lengthwise of the feed chute for pressing the wood in the feed chute against a grindstone. The arrangement comprises rotary feed members between the piston and the grindstone on the sides of the feed chute for pushing the compressed wood further against the grindstone. Also, the arrangement comprises a closing member that can be pushed between the compressed wood and the piston to prevent the wood from moving backward with the piston as the piston is moved to the initial position, ready for the stroke, to allow the feed of a new batch of wood.
Patent FI-970240-A (FI)
Inventor: SACHETTO JEAN-PIERRE
IPC: A61K9/00
Filed: 1997-01-20
Abstract: An aqueous foamable composition is provided having a delayed foaming action on expulsion from a pressurized container. The composition comprises a major amount of water, a water-immiscible liquified gas foaming agent, at least one foam-stabilizing and emulsifying surfactant, and a water-soluble polymer. The composition is particularly useful for rectal or vaginal administration of pharmaceuticals.
Patent FI-974128-A (FI)
Inventor: ROLKE DIETRICH
IPC: B01D39/04
Filed: 1997-11-04
Abstract: The invention relates to a method for the separation of hazardous substances from a waste gas flow, by leading it through a granular absorption bulk material. The bulk material is composed of a mixture of a granular substance with a high carbon content and a granular inert substance. The powder density of the inert substance is 0.8 - 3 times the power density of the substance with a high carbon content. The substance with a high carbon content advantageously accounts for 5 - 80 percent by mass of the bulk material. The substance with a high carbon content may be activated charcoal, activated coke or lignite coke, for example. The inert substance may be silica refractory material, pumice stone, lava, clinker, vitrification residues or gravel, for example.
Patent GB-1294075-A (GB)
Title: Improved forming arrangement
IPC: D21F9/00
Filed: 1970-01-08
Abstract: 1294075 Papermaking BELOIT CORP 8 Jan 1970 [13 Feb 1969] 1022/70 Heading D2A A paper-making machine comprises a slice, first and second wire guides defining between them a narrow gap, third and fourth wire guides spaced successively downstream from the gap, first and second opposed forming wire runs arranged to travel over the first and second guides respectively through initially close spacing, to receive the stock stream, over the third and fourth guides, the third guide having a curved smooth stationary surface pressing on one of the wire runs, the opposed wire run being free from restraint, the third guide guiding the two wires through a curve and away from the stock-stream direction. The fourth guide may be a roll, and may be followed by a fifth guide which is a line of suction boxes which extends horizontally, vertically, or at an angle. A foil may be arranged between the third and fourth guides.
Patent GB-115006-A (GB)
Title: Improvements in Apparatus for Bringing Liquids and Gases, Vapours, Fumes and the like into Intimate Contact.
IPC: B01F5/00
Filed: 1918-01-18
Abstract: 115,006. Davidson, W. B., and Holmes & Co., W. C. Jan. 18, 1918. Rotary apparatus.-Relates to improvements in details of apparatus for securing intimate contact between gases and liquids of the kind described in Specification 9302/14, wherein a rotary shaft passes through a series of superposed compartments, the shaft carrying spraying-devices and means being provided for supplying liquid from a well in the bottom of each compartment. In the construction shown in Fig. 1, the base of the compartment consists of a dish-shaped plate c supported by projecting lugs on a ledge a' formed on the container a, and above it is an overhanging ledge h to deflect the gases. The overflows from one compartment to the next are tubes discharging into dishes k carried by the rotary shaft and supplying liquid to the sprayers m through the tubular supports l. The sprayers are provided with a depending part m<1>, Fig. 7, to scoop up liquid from the basin below, and an additional scoop p may also be provided. In the construction shown in Fig. 4, the dish k is formed with extensions l<1> to which the sprayers m are attached, the tubes l being dispensed with. The disk c may be provided with upstanding baffles t and the ledge h may carry perforated or slotted plates u. The preferred form of sprayer is shown in Fig. 7.
Patent GB-126380-A (GB)
Title: Improvements relating to Gun Carriages.
Inventor: DAWSON ARTHUR TREVOR
IPC: F41A23/28
Filed: 1917-01-20
Abstract: 126,380. Dawson, Sir A. T., and Buckham, Sir G. T. Jan. 20, 1917. Field carriages.-Relates to field carriage bed. plates of the kind which are sunk in the ground and which comprise a support for the carriage wheels and a member against which the rear part of the trail bears and upon which it can be moved to traverse the carriage. The invention consists in providing a rigid triangular structure having the support for the carriage wheels at or near the apex and the support for the trail at or near the base. Fig. 2 shows in plan the triangular structure, the sides of which are formed of wooden beams A, hinged together at the apex by a pin a, and joined at the base by a member A<1> formed of two superposed wooden beams fastened together and to the beams A by bands A<2>. The beams A, A<1> support a metal arc-shaped plate B, which has a channel B<1> forming a support for the rear end of the trail of the gun carriage, and a series of holes whereby the trail may be fixed in position by passing bolts through one or more of the holes and through corresponding holes in a plate B<2> on the trail. The wheels of the gun carriage are supported on platforms C, spaced apart by transverse beams C<1>, and provided with curved angle-irons C<3> against which the inner sides of the rims of the wheels bear when the carriage is traversed on the .structure.. Rope handles to receive hand-spikes a<x> are provided for lifting the partis.
Patent GB-327750-A (GB)
Title: Improvements relating to trailers
IPC: B62D13/04
Filed: 1929-01-11
Abstract: 327,750. Mott, S. F. Jan. 11, 1929. Actuated or applied by relaxation of pull.-A draw bar 4 is connected by a ball and socket joint with the tractor at a point forward of, or over, the rear axle 5 of the tractor. The swivelling wheels 1 of the trailer are connected to a yoke 7 on the joint socket so that angular movements of the vehicles effect steering movements of the wheels 1, while vertical components of such movements are ineffective. The yoke is pivoted at 23, Fig. 3, to the socket which is supported by two sliding spindles 25 in a base 26. A slight degree of play is allowed between arms 24 on the socket and the base 26. If the trailer begins to over-run the tractor the end 28 of the spindle 25 engages a pivoted arm 29 attached to a brake cable 31, the cable is pulled, the trailer is braked, and the over-running ceases. The steering rod 12 passes beneath the body of the trailer, the levers 9, 11 being located at the ends of a long vertical spindle 10. When uncoupled the front of the trailer is supported by a screw jack having a small wheel at the lower end.
Patent GB-194846-A (GB)
Title: Improvements in heat radiating devices for use with internal combustion engines
IPC: H01T13/16
Filed: 1922-01-13
Abstract: 194,846. Yates, C. H. Jan. 13, 1922. Sparking - plugs. - A cooling device for clamping between a cylinder and a sparking-plug, compression tap, valve cap or like fitment, consists of a disc spaced away from a rim which may be in the form of a copper-asbestos washer 2. The disc portion may be corrugated and a tubular intermediate portion 4 may be formed between the disc and rim.
Patent GB-554000-A (GB)
Title: Improvements in or relating to magnetic core structures
IPC: H01F27/245
Filed: 1942-01-28
Abstract: 554,000. Transformers. WESTINGHOUSE ELECTRIC INTERNATIONAL CO. Jan. 28, 1942, No. 1192. Convention date, Jan. 29, 1941. [Class 38 (ii)] [Also in Group XXII] Relates to transformer and like laminated cores of steel which exhibits lower core losses when magnetized in the direction in which it was rolled during manufacture, and consists in making limbs and yokes from strip laminations in which the grain extends longitudinally the ends of the strips being cut at an angle and successive laminations being displaced so that a staggered joint disposed substantially at 45 degrees to the sides of the core is produced at each corner. Figs. 3 and 8 show respectively single phase and polyphase core structures, the full and dotted lines indicating respectively the shape of the laminations in successive layers. Specification 550,191 is referred to.
Patent GB-292433-A (GB)
Title: Process and apparatus for the clarification of benzine
IPC: D06L1/10
Filed: 1928-01-13
Abstract: 292,433. Wack, J. J. Jan. 13, 1928. Oils, purifying; fats, extracting, - To accelerate saponification of contained fats, benzine from dry cleaning, after centrifuging, is injected in a finely atomized state into an alkaline solution containing sodium or potassium carbonate. Common salt or other neutral body to separate the emulsion, and an alkaline bleaching agent, e.g. calcium hypochlorite may be present. The solution is covered with a viscous layer such as glue through which benzine alone passes. In the apparatus shown the benzine passes through a pipe 10 with atomizing nozzles 11 into a tunnel-shaped double-walled chamber 1 with windows 8 and a cross-section increasing upwardly to reduce the speed of the benzine, which passes up through holes 7 into a decanting chamber 2, whence it is withdrawn by a pipe 9. The alkaline solution enters by a pipe 14. Impurities in the chamber 2 enter a pipe 5 of a detachcable filter 4 and are withdrawn by a cock 16. Benzine from a tank r enters a machine w by a pipe 20 and rinses clothes therein; it then passes through a filter f<1>, a pump p, a pipe 22, and centrifugal machine c, and returns by a pipe 25 to the machine w. The benzine next passes by the filter f<1> and pump p into a pipe 28 leading to a clarifier t constructed as above, and this circuit is maintained until completion of washing. The benzine is then pumped into the storage tank r. and the clothes are withdrawn.
Patent GB-370509-A (GB)
Title: Improvements in and relating to laundry ironing and like machines
IPC: D06F65/10
Filed: 1931-01-14
Abstract: 370,509. Endless belt conveyers. POINTON, J. E., Westwood Works, Peterborough, and BAKER PERKINS, Ltd., Willesden Works, Hythe Road, Willesden, London. Jan. 14, 1931, No. 1315. [Class 78 (i).] The tension of the endless aprons or feed tapes 25 of an ironing-machine which pass around a guide roller 24 carried by one arm 26 of a bell-crank lever pivoted at 27 is controlled jointly by springs or weights 30 acting on the other arm 28 of the bell-crank lever and a manually-controlled fluid-pressure operated piston working in a single-acting cylinder 33. The piston rod is connected to the arm 28 of the bell-crank lever and the fluid-pressure acts in opposition to the springs or weights.
Patent GB-304465-A (GB)
Title: Improvements in rotary pumps
IPC: F04B1/04
Filed: 1928-01-16
Abstract: 304,465. Rotoplunge Pump Co., Ltd., and Smith, C. Lakin-. Jan. 16, 1928. Revolving-cylinder pumps. - In a pump of the kind having cylinders 3a arranged radially in a rotor 3, and rigidly connected oppositely disposed pairs of pistons 8a, 8b mounted on laterally sliding blocks 6 which rotate on a fixed eccentric pin 4, the block 6 of each pair slides in a transverse guide-way 8<c> extending through the connecting web of the pistons, and each pair of pistons has a central longitudinal plane adjacent to that of the next pair. The inlet 2b and outlet 2c may be arranged respectively at the side and top of the casing 2.
Patent GB-559805-A (GB)
Title: The manufacture of spark plugs
IPC: H01T21/02
Filed: 1943-01-28
Abstract: 559,805. Spark-plugs. AC-SPHINX SPARKING PLUG CO., Ltd., and CORBIN, D. H. Jan. 28, 1943, No. 1439. Addition to 492,315. [Class 7 (iv)] The spark-plug according to the parent Specification is modified by corrugating the wall 46 of that part of the base of the plug in which the molten metal of the central electrode sets. The corrugations are preferably in spiral formation so that the insulator may be moulded round a central core which may be removed by unscrewing.