baber/WOPTO huggingface dataset:
Patent CR-20170573-A (CR)
Title: Lactamas bicíclicas y métodos de uso de las mismas
Inventor: PATEL SNAHEL
IPC: C07D519/00
Filed: 2016-07-01
Abstract: La invención proporciona compuestos novedosos que tienen la fórmula general I: En donde R1, X, Z1, L, n, el anillo A, el anillo B y el anillo c son tal como se describen en el presente documento, composiciones que incluyen los compuestos y métodos para usar los compuestos.
Patent CR-20210482-A (CR)
Title: Fused ring pyrimidone derivatives for use in the treatment of hbv infection or of hbv-induced diseases
Inventor: JONCKERS TIM HUGO MARIA
IPC: C07D471/04
Filed: 2020-03-13
Abstract: The present application relates to compounds according to Formula (I), pharmaceutical compositions comprising at least one of said compounds, their use as a medicament, and their use in treating chronic hepatitis B virus (HBV) infection. The disclosure further pertains to methods for preparing compounds according to Formula (I).
Patent CR-20220454-A (CR)
Title: Crystalline forms of a fgfr inhibitor and processes for preparing the same
Inventor: TAO MING
IPC: C07D471/04
Filed: 2018-05-25
Abstract: The present disclosure relates to solid forms of N-{[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridin]-6'-yl]methyl}acrylamide, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the FGFR-associated or mediated diseases such as cancer.
Patent CR-20220490-A (CR)
Title: Preparation of mcl-1 inhibiting compound by methylation in the presence of water
Inventor: CUI SHENG
IPC: C07D519/00
Filed: 2021-03-30
Abstract: Disclosed herein is an improved process for the synthesis of compound (A): (A), or a salt or solvate thereof via methylation of compound (B): (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound (A).
Patent CR-20220615-A (CR)
Title: Fungicidal compositions
Inventor: LAMBERTH CLEMENS
IPC: A01P3/00
Filed: 2021-05-27
Abstract: A fungicidal composition comprising a mixture of components (A) and (B), wherein components (A) and (B) are as defined in claim 1, and use of the compositions in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.
Patent EC-SP024276-A (EC)
Title: Un dispositivo portatil que tiene capacidades de autentificacion basadas en biometria
Inventor: POO TENG PIN
IPC: G06F21/34
Filed: 2002-06-28
Abstract: Se describe un método y aparato para implementar autentificación basándose en biometría. En una realización preferida, la presente invención es implementada en un dispositivo portátil. Específicamente, en una realización, el dispositivo portátil incluye un microprocesador, una memoria no volátil acoplada al mismo y un módulo de autentificación basándose en biometría controlado por el microprocesador. Preferentemente, la tecnología de biometría utilizada es tecnología de autentificación de huella dactilar. El método de autentificación es capaz de registrar una huella dactilar después del uso por primera vez del dispositivo portátil, almacenar una versión codificada de la huella dactilar en la memoria no volátil. Subsecuentemente, el módulo de autentificación puede leer la huella dactilar de una persona y determinar de manera confiable si la huella dactilar coincide con la huella dactilar registrada almacenada en la memoria no volátil. Si se encuentra una correspondencia o coincidencia, se concede acceso al recurso restringido a aquella persona; de otra manera se niega el acceso. Así, las realizaciones de la presente invención proporcionan un método y disposición altamente conveniente, seguro y confiable para autentificación del usuario y control de acceso que no era obtenible en los procedimientos de autentificación basándose en contraseña de la técnica previa.
Patent EC-SP034831-A (EC)
Title: Derivados sustituidos de la 2-piridina ciclohexano-1,4-diamina
Inventor: BUSCHMANN HELMUT HEINRICH
IPC: A61P3/04
Filed: 2003-11-07
Abstract: La presente invención se relaciona con los derivados sustituidos de 2-piridina ciclohexano-1,4-diamina, un proceso para su producción, medicamentos que contienen estos compuestos y el uso de derivados sustituidos de 2-piridina ciclohexano-1,4-diamina para la producción de medicamentos
Patent EC-SP066324-A (EC)
Inventor: MERCE VIDAL RAMON
IPC: C07D209/08
Filed: 2006-01-26
Abstract: The present invention refers to new sulfonamide derivatives, of general formula (1a, 1b, 1c), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or their salt thereof s, preferably the corresponding, physiologically acceptable salt thereofs, or corresponding solvate thereofs; to the processes for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.
Patent EC-SP099339-A (EC)
Title: Derivados de pirrol, su preparación y su utilización en terapéutica
Inventor: BARTH FRANCIS
IPC: A61K31/40
Filed: 2009-05-18
Abstract: La invención tiene por objeto compuestos que responden a la fórmula (I) en la que A representa: un grupo alquileno(C1-C6) no sustituido o sustituido; un grupo Fórmula (II) con m = 0, 1 o 2 y p = 0 o 1; R1 representa hidrógeno o un alquilo(C1-C4); R2 representa: un grupo alquilo(C3-C10) no sustituido o sustituido; un radical carbocíclico no aromático de C3-C12, no sustituido o sustituido; un radical heterocíclico no sustituido o sustituido; un grupo alquileno(C1-C3) sustituido; un grupo NR10R11; R9 representa un grupo funcional o un radical heterocíclico; Procedimiento de preparación y aplicación en terapéutica.
Patent EC-SP982595-A (EC)
Title: Compuestos farmaceuticos
Inventor: GALLAGHER PETER THADDEUS
IPC: C07D215/58
Filed: 1998-07-16
Abstract: El invento se refiere a 1. Un compuesto de la fórmula (gráfico), donde R1 es hidrógeno C1-4 alquil, C1-4 alcoxi o halo,, y R2 es hidrógeno, C1-4 alquil o C1-4 alcoxi; o una sales de los mismos.
Patent FI-20040137-A (FI)
Inventor: MATTLAR HARRI
IPC: F16B21/10
Filed: 2004-01-30
Abstract: The invention relates to an arrangement for attaching a switch control shaft to a switch pipe shaft, where the control shaft is mounted partly in the switch pipe shaft and tightened to the switch pipe shaft by a screw. The arrangement comprises a tightening piece. The screw is arranged to act on the control shaft through the tightening piece so that when the screw is turned, the tightening piece is arranged to press the control shaft against the pipe shaft so that the control shaft tightens fast between the tightening piece and the pipe shaft.
Patent FR-1603765-A (FR)
Title: Cosmetics contg fatty acids, cholesterol and cystine
IPC: A61K31/16
Filed: 1968-11-18
Granted: 1971-05-24
Abstract: Cosmetic compns. for the treatment of hair and contain palmitic acid, oleic acid, Ca linoleate, cystine and cholesterol. They are formulated as creams for the treatment of nails to prevent breakage and stimulate growth, and as lotions for the treatment of the scalp to increase hair growth. In an example a cream was prepared containing 1g palmitic acid, 1g oleic acid, 0.5g Ca linoleate, 5g cystine, 5g cholesterol, 3g eucalyptol, 1g methyl nicotinate, and 83.5g polyoxyethylene glycol stearate.
Patent GB-1052633-A (GB)
IPC: A61M16/10
Abstract: 1,052,633. Respiratory appliances. H. BLOOM. July 5, 1963 [April 5, 1962], No. 13215/62. Heading A5T. An apparatus for the treatment of colds, catarrh and disorders of the respiratory tract comprises a mask 1 adapted to fit in an airtight manner at least over the nostrils and mouth of a patient, the mask 1 having an air inlet valve 30 and air outlet valve 8, the inlet valve 30 being biased towards the closed position by spring 34 such that it opens only when a predetermined partial vacuum has been created within the patient's respiratory track. To alter the partial vacuum required to open valve 30 the action of spring 34 on valve 30 is altered by adjusting the position of plug 23 which bears on spring 34. The outlet valve 8 may be a cone or diaphragm type valve. A subsidiary inlet valve 20 is provided in side arm 19 of tube 18. The air may be heated by coil 37 before entering the mask 1. Gas other than air may be introduced, e.g. between the inlet valve and heating means.
Patent GB-1053091-A (GB)
IPC: C10L1/22
Abstract: 1,053,091. Fuels. ESSO RESEARCH & ENGINEERING CO. April 2, 1964 [April 9, 1963], No. 14210/63. Heading C5G. Hydrocarbon fuels for I.C. engines comprise a lead anti-knock agent (e.g. TEL), from 0À0005- 0À5 gram-equivalents per U.S. gallon of fuel of an ammonium or amine salt of a secondary, tertiary or acyclic branched-chain primary carboxylic acid, and a minor quantity, at least sufficient to solubilize the salt, of an alcohol (e.g. ethanol). Many suitable salts are specified, the following being used in specific examples: ammonium 2-ethyl hexanoate, isobutylamine 2-ethyl hexanoate, and ammonium isovalerate.
Patent GB-1053547-A (GB)
IPC: A24D3/02
Abstract: 1,053,547. Cigarette-making machines. DESMOND, W. MOLINS and T. ROWLANDS. Sept. 5, 1963 [Sept. 5, 1962], No. 34067/62. Heading A2C. A method of making composite mouthpiece rod comprises the steps of feeding lengthwise simultaneously a plurality of continuous rods of mouthpiece material, cutting each rod transversely of its length to sever components of a desired length therefrom, spacing apart endwise successive components severed from each rod, feeding the spaced components severed from the rods in timed relationship in such a way as to move the components into axial alignment with one another in a desired sequence, and wrapping the aligned components in a continuous wrapper to form a continuous composite mouthpiece rod. Two filters F1 and F2 of different mouthpiece materials are wrapped in webs 1 by conveyance through parallel garnitures 4 to form two continuous rods R1 and R2 which are cut into component lengths C1 and C2 by a rotating knife 9. The components travel over a bridge 11 to an endless air-pervious band 12 above which a rotating wheel 15 is positioned. The wheel 15 has two grooves each provided with a series of groups of suction ports, the groups which communicate with one groove being offset from those which communicate with the other groove. The wheel 15 rotates at a faster peripheral speed than the linear speed of the rods R1 and R2 so as to space apart successive components C1 and C2 by an amount greater than the length of the components C2 and C1 respectively. The spaced components then pass to the conveyer band 12 which runs over a plate 22 having laterally spaced slots 23, 24 therein through which suction is applied. The slots 23, 24 converge to a point 25 to that single row of alternate components C1, C2 is formed. A wheel 26, provided with pusher elements 27 controlled by a fixed cam 33, is rotated so that each successive component C2 is engaged by a pusher 27 and moved into endwise abutment with the preceding component C1, the components then being conveyed over a plate 28 to an endless conveyer band 35. The band 35 co-operates with a band 36 to slow down the pairs of components until they abut. The abutted components are then fed through a garniture 40 in which a web W is wrapped around them to form a continuous composite mouthpiece rod CR. The rod CR then passes to cut-off mechanism 43, the severed lengths L being transferred by a grooved suction wheel 47 to a fluted drum 48 which delivers them on to a band 49. Instead of turning the components through 180 degrees as shown in Fig. 1, the wheel 26 may turn them through only 90 degrees (Fig. 6, not shown). Alternatively the components C1 and C2 may be abutted by a worm-wheel so that no turning is required (Fig. 7, not shown), or by a pair of rotating pusher wheels (Fig. 8, not shown). In a further embodiment (Fig. 9, not shown) three continuous rods are cut into individual components which are then spaced, abutted and finally wrapped to form a continuous composite mouthpiece rod.
Patent GB-1225171-A (GB)
IPC: H03H7/01
Filed: 1968-04-01
Abstract: 1,225,171. Tuning arrangements. TELEFUNKEN PATENTVERWERTUNGS G.m.b.H. 1 April, 1968 [19 April, 1967], No. 15627/68. Heading H3Q. In a variable tuning arrangement including two resonant lines 4, 5 grounded at one end and inductively coupled together, each line is tuned by respective variable capacity diodes 8, 9 which are connected to ground via capacitors 13 and 14 and are joined by a coupling coil 16. Control voltages for the diodes 8, 9 are supplied via a pre-set resistor 12 to diode 8 and via coil 16 to diode 9. The outer conductor of the #/4 resonant lines 4 and 5 is formed by a housing 1 and partition 6. The lines 4 and 5 are coupled by a loop 15. The tuner may be for a U.H.F. radio and may include an oscillator resonant circuit 17. At high frequencies the voltages developed at the junctions 18, 19 are low so that the coupling obtained via coil 16 is very loose whereas for lower frequencies the voltages developed at the junctions are greater and the reactance of the coil 16 is lower so as to obtain closer coupling.
Patent GB-1227216-A (GB)
IPC: E21C29/22
Filed: 1968-06-21
Abstract: 1,227,216. Railway vehicle undercarriages; elevated railway systems. BECORIT (RESEARCH) Ltd. 21 Aug., 1969 [21 June, 1968], No. 29610/68. Heading B7L. [Also in Division E1] Mineral mining apparatus comprises a face conveyer 10, a coal-getting machine 20 mounted on the conveyer for travel therealong, and driving means 50 for moving the machine including a rail 51 engaged on opposite sides by driven members 55 which are urged towards the rail so as to grip it. The conveyer is connected to self-advancing roof supports 30 and comprises a plurality of articulately connected sections. The driven members 55 are formed by wheels having tyres and driven by hydraulic motors 58, and they are carried by pivoted arms 56 interconnected by hydraulic rams 57 for urging the wheels towards the rail. One of the wheels may be provided on each side of the rail or two may be provided on one side of the rail and one, intermediately positioned between the two, on the other. Only one of the wheels may be driving and the hydraulic rams may be replaced by a turnbuckle. The driven members may be provided on a bogie at one end of the machine and a similar bogie may be provided at the other, the bogies having running wheels engaging an upper flange 53 of the rail 51. Back-up wheels may be urged into engagement with the other side of the flange 53. In a second embodiment, Fig. 3 (not shown), the rail is carried by the roof supports 30 and the wheels engage a vertical web of the rail. The wheels are connected directly to the motors which are pivoted for movement by hydraulic rams to engage the wheels with the rail. In a third embodiment, Fig. 4 (not shown), the wheels engage a horizontal flange, the upper wheels are connected directly to their motors and the lower wheels only are pivoted for movement by hydraulic rams to engage the flange. The wheels may be replaced by an endless belt passing round driven pulleys, the belt having a portion urged into rail contact.
Patent GB-1227561-A (GB)
IPC: B60V1/00
Filed: 1968-02-16
Abstract: 1,227,561. Air cushion vehicles. BRITISH HOVERCRAFT CORP. Ltd. 22 Jan., 1969 [16 Feb., 1968], No. 7677/68. Heading B7K. The cushion 13 of a maritime A.C.V. is bounded at the sides by the downwardly extending rigid walls of air supply ducts 18 with flexible skirts 24 of segment type depending therefrom, and at the front and back by flexible skirts 25, 26 respectively, also of segment type, and is subdivided by a planing hull 12 of stepped or hive form, whilst flexible inflatable fenders 19 are secured to the sides of the rigid walls. The hull 12, which may provide additional support in rough weather and may give lift at normal operating speeds, contains the engine 15 and transmission gear-box 20 to a water propeller 23 thus increasing stability by keeping the centre of gravity low. The segments at the front 25 and sides 24 are preferably open to the cushion while those at the back 26 are in the form of closed cones to avoid scooping up water. Specification 952,772 is referred to as exemplary of the skirting assembly.
Patent GB-1227563-A (GB)
IPC: B01J31/16
Filed: 1968-05-02
Abstract: 1,227,563. Olefine conversion catalyst. PHILLIPS PETROLEUM CO. 2 May, 1968 [3 May, 1967; 28 March, 1968], No. 20829/68. Heading B1E. [Also in Divisions C3 and C5] A catalyst composition is the product formed on mixing (a) a complex [Ma(L) b X a ] x  wherein M is Mn, Tc or Re; L is a ligand selected from R 3 G, R 3 QO, R 2 Q-QR 2 , R-S-R, R<SP>5</SP>(CN) m , pyridine or optionally R<SP>5</SP> substituted 2, 2'-bipyrinidine, -O-, (#- CHR<SP>4</SP>-CR<SP>4</SP>-CH 2 -), (R 2 NCSS-) or [(RCO) 2 CH-] wherein Q is P, As or Sb, R is optionally halo and alkoxy substituted aromatic or saturated aliphatic of up to 20 carbon atoms, R<SP>4</SP> is H or Me, R<SP>5</SP> is an aromatic or saturated or ethylenically unsaturated aliphatic radical of up to 30 carbon atoms and m is 1-2; X is halogen; a is an integer from I to 6, b is 1 to 3 and X is indicative of polymeric state of the complex; the number of (L) and Z groups not being greater than that required for the metal to achieve the electronic configuration of the next inert gas and (b) an Al containing adjuvant selected from (i) one or more of ReAlXf (ii) AlX 3  or (ii) a mixture of (i) or (ii) with R<SP>1</SP> g M<SP>1</SP>X h , wherein R<SP>1</SP> is H or R, M<SP>1</SP> is a metal from Group IA, IIA, IIB or IIIA, e is 1-3, f is 0-2 and e+f is 3, g is 1-3, h is 0-2 and g+n is valency of M<SP>1</SP>. Many examples of (L), Al compounds and Re and Mn complexes specified. The catalysts may be employed in vapour phase on a support such as Al 2 O 3 , SiO 2 , Al 2 O 3 -SiO 2 , TiO 2 , B 2 O 3 , zeolites, ion exchange resins and solid polymers.
Patent GB-1228054-A (GB)
IPC: A47L13/252
Filed: 1968-10-01
Abstract: 1,228,054. Brushes; mops. J. HOLMAR. 16 Sept., 1969 [1 Oct., 1968], No. 46474/68. Headings A4K and A4F. A cleaning appliance comprises like bundles 10 of long dressed hemp or jute fibres and a hollow head to which the bundles after being folded into staple form are detachably secured. The hollow head comprises a rectangular, circular or barrellshaped back plate 14 of aluminium or methyl methacrylate having marginal notches (13, Figs. 3 and 4, not shown) in which the heads of the staples are engaged and anchored by threading through the heads a wire, rod of aluminium or copper or a nylon cord 16, and a cover 17 which is secured to the back plate by head screws or studs 20. Water which may be supplied through a hollow handle (28) (Fig. 6, not shown) passes to the fibres through small holes (29) or a single large hole (30) in the back plate (Fig. 2, not shown).
Patent GB-1228160-A (GB)
IPC: B30B11/16
Filed: 1967-10-03
Abstract: 1,228,160. Roller briquetting press. COAL INDUSTRY (PATENTS) Ltd. 24 Sept., 1968 [3 Oct., 1967], No. 44902/67. Heading B5A. [Also in Division G3] In a roller briquetting press for char comprising a pair of parallel rolls 8 on fixed axes and each provided with co-operating cavities 9 around the periphery thereof, the pressure within the cavities 9 is maintained constant by automatically varying the speed of a rotary precompaction packer 10 by means of load cells which sense the roll separating force and a signal wherefrom is compared with a reference signal corresponding to a desired roll load, e.g. to increase the speed of the packer when the roll speed is increased. The char is produced by the fluidized bed carbonization of coal in a container 1 wherefrom it is fed whilst hot to hoppers 13, each associated with a roll pair 8, through rotary valves 16 the speed whereof is controlled by level indicating means 15, to maintain a constant level in each hopper 13.
Patent GB-1228565-A (GB)
IPC: B21C37/02
Filed: 1969-03-10
Abstract: 1,228,565. Shearing; making section beams; profiling. S. V. JANSSON. 10 March, 1969 [11 March, 1968], No. 12531/69. Headings B3A, B3E and B3W. A metal strip 2 is weakened transversely prior to section rolling so that the strip divides transversely during the rolling. The strip may be hot or cold and fed from a reel 1 through a machine 3 which scores the strip. The machine 3 comprises two beams between which the strip passes and a carriage 4 is slidably mounted on each beam. The carriages are moved by chains and each have three cutter discs 5 which score the strip. Alternatively, the strip may be perforated or weakened by a guillotine with controlled movement. The depth of the score is adjustable in dependence on the strip material and thickness and the strip position when it divides. The strip divides from its centre as it passes through the roll pairs 7, 8 and the final roll pair 9 guides the strip after division. The line of weakness may be in any direction across the strip.
Patent GB-1229158-A (GB)
IPC: C22C3/00
Filed: 1969-02-10
Abstract: 1,229,158. Disintegrating sintered masses. W. M. SHWAYDER. 10 Feb., 1969, No. 7169/69. Heading C1A. Sintered hard carbide masses formed of hard carbide particles (e.g. TaC, WC and TiC) and cemented by cobalt are disintegrated by treatment with dilute phosphoric acid at just above room temperature, whence the cobalt dissolves in the acid freeing the particles in essentially, their presintered sizes as a suspension in the acid, followed by mechanical separation of the particles from the acid (e.g. by centrifuging or filtering). The masses are preferably autogenously milled during the process, e.g. by vibration. Specified conditions are 5-40% phosphoric acid, and an oxygen atmosphere of 5-50 p.s.i. or a small addition of hydrogen peroxide.
Patent GB-1230819-A (GB)
IPC: G01N29/07
Filed: 1968-08-14
Abstract: 1,230,819. Ultrasonic inspection systems. INTERNATIONAL MEEHANITE METAL CO. Ltd. 7 Aug., 1969 [14 Aug., 1968], No. 38915/68. Heading H4D. The degree of modularity of the graphite in a batch of molten iron to be cast is assessed prior to casting of the bulk of the batch by casting a sample billet, quenching the billet before expiry of a predetermined time period, displaying on an oscilloscope screen an ultrasonic echo signal obtained from the billet and comparing the signal with a datum line on the screen, the datum representing the echo signal propagation time for a similarly-prepared billet of known modularity. By casting and quenching all billets under the same conditions, variability of the matrix or grain structure and its effect on the assessment are small. The sensitivity of the assessment to variations in the graphite modularity is greatest if the predetermined period is made less than two minutes. The ultrasonic echo signal is obtained by placing the quenched billet on a submerged piezo-electric probe and is from the back surface of the billet.