baber/WOPTO huggingface dataset:
Patent CA-2287387-A1 (CA)
Title: Methods and compositions for destruction of selected proteins
Inventor: ROSEN NEAL
IPC: C07J17/00
Filed: 1998-05-14
Abstract: Compounds having an ansamycin antibiotic, or other moiety which binds to hsp90, coupled to a targeting moiety which binds specifically to a protein, receptor or marker can provide effective targeted delivery of the ansamycin antibiotic leading to the degradation of proteins and death of the targeted cells. These compositions may have different specificity than the ansamycin alone, allowing for a more specific targeting of the therapy, and can be effective in instances where the ansamycin alone has no effect. Thus, these compounds provide an entirely new class of targeted chemotherapy agents with application, depending on the nature of the targeting moiety, to treatment of a variety of different forms of cancer. Such agents can further be used to promote selective degradation of proteins associated with the pathogenesis of other diseases, including antigens associated with autoimmune disorders and pathogenic proteins associated with Alzheimer's disease. Exemplary targeting moieties which may be employed in compounds of the invention include testosterone, estradiol, tamoxifen and wortmannin.
Patent CA-2287704-A1 (CA)
Inventor: TONEY KENNETH A
IPC: A44B19/36
Filed: 1998-04-24
Abstract: A reclosable fastener assembly comprising a first fastener strip (14), a second fastener strip (15) and a slider (10). The first fastener strip has an inner surface and an outer surface, including at least an uppermost closure element (16a) and a bottommost closure element (16b) positioned along the length of the inner surface. The second fastener strip has an inner surface and an outer surface, including at least an uppermost closure element (17a) and a bottommost closure element (17b) positioned along the length of the inner surface. The closure elements along the second fastener strip are adapted to engage with the closure elements along the first fastener strip, thereby interlocking the second fastener strip with the first fastener strip. The slider has a top (20) and side (21, 22) walls depending from opposite sides of the top for receiving the fastener strips therebetween, the side walls extending downward from the top to a point below the uppermost closure elements, so that at least a portion of the fastener strips are held between the side walls. The side walls also extend from a separating end (10a) of the slider to a pinching end (10b). Pinching means are positioned proximate to the pinching end. The slider also includes a separating leg (23) depending from the top between the first and second side walls at the separating end of the slider. The separating leg penetrates at least one of the uppermost closure elements of the first or second fastener strips, but not the bottommost closure elements.
Patent CA-2288454-A1 (CA)
Title: Multi-layer tubing assembly for fluid and vapor handling systems
Inventor: HSICH HENRY S
IPC: B29C48/09
Filed: 1999-11-04
Abstract: A multi-layer tubing for use in fluid transport applications. The tubing is suitable for conveying fluids containing hydrocarbons. The tubing comprising an extrudable adhesive layer coextruded around a permeation-resistant layer of fluoropolymer and a layer of polymer chemically dissimilar from fluoropolymer coextruded around the adhesive . The adhesive layer is formed of a polymer blend or alloy having a multi-phase morphology wherein one phase is miscible with the fluoropolymer for forming the inner permeation-resistant layer and another phase is miscible with the polymer chemically dissimilar from fluoropolymer. To achieve sufficient bonding, the adhesive layer comprises at least 25%  volume fraction of the first phase which is miscible with the fluoropolymer for forming inner permeation-resistant layer and at least 25 % volume fraction of the second phase which is miscible with the polymer chemically dissimilar from fluoropolymer.   Furthermore, the adhesive layer of polymer blends or alloys having a multi-phase morphology  can be modified by adding compatibilizers and rheology modifiers to improve adhesion strength and to allow the material for forming the adhesive layer to obtain proper viscosity and elasticity for extrusion.
Patent CA-2289068-A1 (CA)
Inventor: GREEN JOHN L
IPC: E01F9/06
Filed: 1998-05-08
Abstract: A raised road marker (200) has a flat bottom surface (208) with an outer periphery. At least one cavity (214, 216) opens onto the bottom surface laterally inwardly of the periphery and extends upwardly into the marker body.  A venting groove (218) extends along the bottom surface (208) from the cavity (214, 216) to the periphery to provide a vent for air trapped in the cavity (214, 216) when the marker is urged into a pool of adhesive to secure the marker to a roadway. The venting of air provides a stronger bond between the marker and adhesive. Markers having a rounded top surface (202) may be provided with a flat bottom portion (204) with abutment surfaces (210) to facilitate movement of a line of the markers in an automated system.
Patent CA-2289468-A1 (CA)
Inventor: RAGNO MICHAEL A
IPC: B29C65/36
Filed: 1998-05-12
Abstract: L'invention porte sur un procédé de raccordement d'un réceptacle (12) thermoplastique rigide à un conduit (14) thermoplastique flexible ou thermodurci élastomère à l'aide de techniques de raccordement électromagnétique. Le conduit (14) thermoplastique flexible ou thermodurci élastomère est conçu de façon à être étroitement raccordé sous des forces compressives à un élément coopérant (16) du réceptacle (12) thermoplastique rigide au moyen d'un adhésif (20) de raccordement électromagnétique placé avant application d'une force électromagnétique.
Patent CA-2293110-A1 (CA)
Title: Conductive elastomer interconnect
Inventor: MICHAUD ARTHUR G
IPC: H01H1/029
Filed: 1999-12-23
Abstract: An electrical interconnect comprising a non-conductive substrate having respective opposite surfaces and a plurality of apertures formed therein extending between the respective opposite surfaces, and a corresponding plurality of elastic conductive interconnect elements located within the plurality of apertures, in which each elastic conductive interconnect element extends between the respective opposite surfaces of the substrate. Each elastic conductive interconnect element is formed of a non-conductive elastic material having a quantity of conductive flakes and a quantity of conductive powder granules interspersed therein. The interconnect elements can be integrally molded in the substrate or separately formed and inserted in the substrate.
Patent CA-2293201-A1 (CA)
Inventor: ROUTLIFFE STEPHEN
IPC: H04M3/26
Filed: 1999-12-23
Abstract: A device for measuring the bit error rate of a telecommunications channel is mounted on a peripheral PC card and inserted into a card slot of a personal computer. The device is responsive to external program commands from the PC. A pseudo random sequence generator generates a pseudo random sequence and sends it through an output means for connection to a time division multiplexed telecommunications link in response to program commands received from the PC.
Patent CA-2293718-A1 (CA)
Title: Procede de detection precoce des maladies cardiaques
Inventor: SABBADINI ROGER A
IPC: G01N33/68
Filed: 1998-05-22
Abstract: Cette invention concerne des procédés, des compositions, des kits et des dispositifs permettant de détecter l'ischémie cardiaque, l'hypoxie ou d'autres causes d'insuffisance cardiaque chez un mammifère. Les procédés consistent à prélever un échantillon test provenant d'un mammifère, à mesurer un niveau d'un marqueur cardiaque non polypeptidique dans l'échantillon test et à déterminer si le niveau du marqueur cardiaque mesuré dans ledit échantillon test est en corrélation avec l'ischémie cardiaque, l'hypoxie ou une autre forme d'insuffisance cardiaque.
Patent CA-2296341-A1 (CA)
Inventor: ARNOLD CHARLES A
IPC: B02C13/14
Filed: 1998-07-17
Abstract: Cette invention concerne un dispositif pulvérisant un matériau, composé d'objets distincts humides ou anhydres, en particules relativement plus petites et ce, au moyen d'ondes de choc créées par l'écoulement dudit matériau dans un contenant doté de rotors alternés (92, 94, 96, 98) et de plaques à orifices (128, 130, 134, 136). Ce contenant comporte une première extrémité munie d'une goulotte d'alimentation (78) destinée à introduire le matériau dans le contenant; une seconde extrémité munie d'une ouverture permettant d'extraire les petites particules; et des parois internes se rejoignant au niveau d'angles et s'étendant longitudinalement entre les première et seconde extrémités. Les rotors s'étendent le long d'un arbre rotatif situé dans le contenant, chaque rotor comportant une plaque polygonale et des pales s'étendant dans le sens radial.
Patent CA-2297601-A1 (CA)
Title: Method and apparatus for making stretchable absorbent articles
Inventor: NEASE MICHAEL GARY
IPC: A61F5/44
Filed: 1995-11-22
Abstract: A method and apparatus for making stretchable absorbent diaper articles. An absorbent material is provided and entangled with a stretchable material to form a stretchable network incorporating the absorbant material. In one embodiment a plurality of foam absorbent material particulates are drawn or accelerated by gravity, vacuum or forced air through a stream of a meltblown adhesive that contacts and entangles the particulates and forms a stretchable network incorporating the particulates.
Patent CA-2298794-A1 (CA)
Title: Sewing machine with fabric-retaining bed and method for sewing fabric
Inventor: HINSPERGER PETER
IPC: D05B75/00
Filed: 2000-02-15
Abstract: A sewing machine for sewing large work pieces such as sails or tarps, has a sewing bed with a large trough, the axis of which is perpendicular to the axis of the sewing head support arm. Fabric is held within the trough, either by being folded, bunched or rolled, with fabric being either fed into the trough as stitching progresses, or is drawn out of the trough during stitching. The fabric may be rolled, bunched or folded within the trough. The trough may be selectively covered with a removable cover plate, to provide an entirely flat sewing bed for sewing of smaller pieces of fabric.
Patent CA-2299311-A1 (CA)
Title: Method and apparatus for inducing hypothermia
Inventor: FOX JAMES A
IPC: A61F7/12
Filed: 1998-08-10
Abstract: The invention relates generally to methods and apparatus for inducing hypothermia in an animal. Known methods for inducing hypothermia all involve cooling the outside or inside of an animal, sometimes in conjuction with drugs that disable the animal's homeostatic responses. The present invention is directed to a method and apparatus for applying heat to the hypothalamus of a warm-blooded animal in order to utilize the physiological mechanisms that regulate body temperature to effect a compensatory cooling response, thereby lowering body temperature. It is new and unsuggested in the art to apply heat in an effort to reduce body temperature. The invention effects the desired lowering of body temperature by the method of raising the temperature of the hypothalamus, a brain structure situated in humans just above the pituitary gland responsible for temperature regulation, by warming a nasal passage, or a sinus, such as the sphenoid sinus that is nearest to the hypothalamus, or by direct warming of the hypothalamus, or a combination of these.
Patent CA-2300069-A1 (CA)
Title: Naphthalimidobenzamide derivatives
Inventor: SUZUKI KENJI
IPC: C07D401/14
Filed: 1999-07-02
Abstract: The present invention relates to a naphthalimidobenzamide derivative represented by the following formula (1): (see formula 1) (wherein, R1 represents a hydrogen atom, etc., Y represents a hydrogen atom or -CON(R4)-A2-X2, R2 and R4 are the same or different and each independently represents a hydrogen atom, etc., A1 and A2 are the same or different and each independently represents an alkylene group which may be interrupted at least once by -N(R3)- (R3 representing a hydrogen atom, etc.) and X1 and X2 are the same or different and each independently represents a (hetero)aryl group which may have a substituent, etc.) or salt thereof; and a pharmaceutical comprising it as an effective ingredient. The compound is useful as an antitumor agent and the like.
Patent CA-2300810-A1 (CA)
Inventor: LOHMANN DIETER
IPC: B29D11/00
Filed: 1998-08-31
Abstract: The present invention relates to a process for the manufacture of a molding, which comprises the following steps: a) providing at least one prepolymer comprising one or more crosslinkable groups, wherein the prepolymer is an amphiphilic segmented copolymer comprising at least one hydrophobic segment A and one hydrophilic segment B; b) preparing a mesophase of the prepolymer which is at least partly bicontinuous; c) introducing the mesophase obtained into an ophthalmic mold; d) triggering of the crosslinking; and e) opening the mold such that the molding can be removed. The process of the invention is particularly suited for the manufacture of membranes and ophthalmic moldings such as contact lenses.
Patent CA-2301707-A1 (CA)
Title: Improved agrobacterium-mediated transformation of plants
Inventor: DIRKS ROB
IPC: A01H5/00
Filed: 1998-08-25
Abstract: Agrobacterium strains which have lost the capacity to proliferate vigourously in vitro or in planta, are provided, as well as transformation methods using these Agrobacterium strains.
Patent CA-2301910-A1 (CA)
Inventor: WILLIS STEVEN R
IPC: H04L12/56
Filed: 1999-06-18
Abstract: An interconnect network for operation within communication node, wherein the interconnect network may have features including the ability to transfer a variety of communication protocols, scalable bandwidth and reduced down-time.  According to one embodiment of the invention, the communication node includes a plurality of I/O channels for coupling information into and out of the node, and the interconnect network includes at least one local interconnect module having local transfer elements for transferring information between the plurality of I/O channels; and scaling elements for expanding the interconnect network to include additional local interconnect modules, such that information can be transferred between the local interconnect modules included in the interconnect network.
Patent CA-2302106-A1 (CA)
Title: Measurement of pipe joint misalignment at weld interface
Inventor: PRENTICE GARTH RODNEY
IPC: B23K31/02
Filed: 2000-03-24
Abstract: A method of monitoring the alignment of pipes to be welded end to end involves supporting a reference bar extending generally parallel to, and external of, the pipes so as to span a weld position of which the ends of two pipes are to be welded, performing measurements of perpendicular distance between the bar and each pipe at two predetermined distances from the end of each pipe, determining the thickness of the walls of the pipes, determining the slope of the exterior of each pipe with respect to the reference bar, calculating from the slopes the difference between the distances from the bar to the outer surface of each of the two pipes to the weld position, so as to provide a measure of the misalignment of the outer surface of the pipes at the weld position, differencing the wall thicknesses of the pipes to provide a wall thickness difference, and subtracting the wall thickness difference from the misalignment of the external walls of the pipe to determine the misalignment of the inner surfaces of the pipes at the weld position. It is preferred to measure pipe thicknesses at multiple distances from the end of each pipe and average the results to obtain average thicknesses for the two pipes. The misalignment measurements will usually be repeated at successive points around the periphery of the pipes.
Patent CA-2302688-A1 (CA)
Title: Composite proppant, composite filtration media and methods for making and using same
Inventor: MCDANIEL ROBERT R
IPC: B01J2/20
Filed: 1999-07-22
Abstract: Composite particles (82) made of a resin (12) and filler material (14) are provided for use in subterranean formations. The filler (14) is finely divided mineral and optional fiber. The particles (82) are proppants useful to prop open subterranean formation fractures. The particles (82) are also useful for water filtration. Methods of making the composite particles (82) are also disclosed.
Patent CA-2307107-A1 (CA)
Inventor: MASUDA HARUHIKO
IPC: A61B17/00
Filed: 1999-08-20
Abstract: A pressurizing unit (17, 20) and a distal device (1) are connected via a fluid circuit so as to infuse a fluid into the distal device (1) and the fluid circuit is provided with a control device (10, 11) for controlling the movement of ligating rings (13). The control device (10, 11) detects a pressure drop within the distal device (1) occurring when one or a plurality of ligating rings (13) disengage from the distal device (1) and stops the movement of the ligating rings (13) according the pressure drop so as to allow at least two ligating rings to disengage in a desired number at a time, thereby permitting a continuous ligating treatment on a varicosity or a hemorrhoid.
Patent CA-2308497-A1 (CA)
Title: Catv return path impairment detection and location system
Inventor: GOTWALS MICHAEL D
IPC: H04N7/24
Filed: 1999-09-02
Abstract: A method of detecting impairments is employed in a multichannel communication system operable to transmit signals on plurality of channel frequencies. A  first step of the method involves transmitting from a headend unit one or more information signals on the multichannel communication system, the one or more information signals including information identifying one or more frequencies to be measured. A second step of the method comprises transmitting a trigger signal on the multichannel communication system. In other steps of the method, first and second remote units operably connected to different locations on the multichannel communication system receive at least one of the information signals and the trigger signal. Each of the first and second remote units then perform, responsive to the trigger signal, a measurement measuring a signal level corresponding to at least a first frequency of the frequencies to be measured, the first frequency identified in the received at least one of the information signals. The first and second remote units perform the measurement at about the same time.
Patent CA-2309707-A1 (CA)
Title: Trigger-type liquid discharge container usable in both ordinary and inverted postures
Inventor: NAKAMURA HIROYUKI
IPC: B05B11/00
Filed: 1999-09-10
Abstract: The present invention proposes a trigger-type liquid discharge container which can be used in an inverted posture and in a horizontal posture having its ejection pipe directed downward.      Said container is constructed, by fitting the upper portion of a liquid suction tube 121, in which a valued tube 141 and a suction pipe setting tube 151 are fitted, in a base tubular portion 103; by providing communication between a suction pipe 156 depending from a second longitudinal tube 154 and a main tube 106 through both a first longitudinal tube 144 and the second longitudinal tube 154, which respectively extend through first and second transverse walls 142 and 152 of the valued tube and the suction pipe setting tube; by forming a liquid suction port 127 for the inverted posture in the front portion of the upper end of the liquid suction pipe portion, as depending downward from the lower end of the base tubular portion 103; by providing an air suction preventing valve 162 in the front portion of the first transverse wall 142 under said suction port, and by forming an opening 148 in the longitudinal tube portion between the first and second transverse walls 142 and 152.
Patent CA-2314682-A1 (CA)
Title: A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride
Inventor: LUKE WAYNE DOUGLAS
IPC: A61K31/57
Filed: 2000-07-28
Abstract: The present invention is directed to a novel crystalline hydrate of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride and uses for same, including inhibition of disease states associated with estrogen deprivation including cardiovascular disease, hyperlipidemia, and osteoporosis; and inhibition of other pathological conditions such as endometriosis, uterine fibrosis, estrogen-dependent cancer (including breast and uterine cancer), prostate cancer, benign prostatic hyperplasia, CNS disorders including Alzheimer's disease, prevention of breast cancer, and up-regulating ChAT.
Patent CA-2314945-A1 (CA)
Inventor: CHADBOURNE RICHARD
IPC: H01R4/24
Filed: 1998-11-10
Abstract: A wedge connector with a shell (10) and a wedge (12). The shell (10) has insulation piercing sections (46) to pierce through insulation of electrical conductor cables (A, B). The wedge has a frame and piercing supports movably attached to the frame. The piercing supports pierce through insulation of the cables such that conductors in the cables are directly contacted by both the shell and the wedge.
Patent CA-2315143-A1 (CA)
Inventor: SUZUKI TOYOAKI
IPC: C12N9/10
Filed: 1998-10-23
Abstract: L'invention concerne un procédé de purification de substrats de thrombine et/ou d'inhibiteurs de thrombine, caractérisé par l'étape consistant à effectuer une chromatographie d'affinité au moyen d'un adsorbant d'affinité contenant une thrombine ou un analogue de celle-ci dont on a supprimé l'activité (nucléophile) sans provoquer d'encombrement stérique dans la capacité de liaison, comme ligand, à des substrats et/ou des inhibiteurs. Le procédé vise à mettre en oeuvre une purification efficace, sûre et stable de substrats de thrombine et/ou d'inhibiteurs de thrombine bon marché et de grande pureté, par un nouveau moyen de séparation/purification utilisant une procédure adéquate de séparation/purification et comportant un petit nombre d'étapes de purification/séparation. L'utilisation du procédé mentionné permet d'obtenir des facteurs de coagulation VIII et XIII, de protéine C etc. de grande pureté et d'assurer des rendements élevés par comparaison avec des procédés de purification classiques.
Patent CA-2318030-A1 (CA)
Title: Acpl dna and polypeptides
Inventor: BORN TERESA L
IPC: C07K19/00
Filed: 1999-01-22
Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
Patent CA-2318379-A1 (CA)
Title: Lignees cellulaires recombinees pour le criblage de medicaments
Inventor: THIGPEN ANICE E
IPC: A61K35/12
Filed: 1999-01-11
Abstract: La présente invention concerne des méthodes de criblage pour la détection de modulateurs de fonction sécrétoires. En particulier, l'invention décrit des cellules sécrétoires neuro-endocriniennes immortalisées permettant de cribler de nouvelles substances pouvant s'utiliser pour réguler la fonction sécrétoire in vitro et in vivo.