baber/WOPTO huggingface dataset:
Patent MY-192076-A (MY)
Title: Device and method for monitoring and controling indoor parameters
Inventor: AZMAH BINTI SHUIB
IPC: G05B19/042
Filed: 2017-10-09
Abstract: A device (102) and a method for monitoring and controlling indoor parameters is provided. The device (102) comprises one or more sensors, an Internet Of Things (IOT) communication module (210), a relay module (212), and a controller (202). The one or more sensors are configured to measure one or more indoor parameters. The controller (202) is configured to receive data from the one or more sensors, and compare the received data with a predetermined range data. The IOT communication module (210) communicates the received data with a remote server in a timely manner and an alert is send to one or more registered devices in case a value resulting from the comparison is out of the predetermined range data. Thereafter, the operation of one or more external appliances is controlled. (Figure 1)
Patent MY-182497-A (MY)
Title: Ocular implant delivery device and method
Inventor: BIANCHI KEITH
Filed: 2015-07-15
Abstract: An ocular implant system including an ocular implant sized and shaped to be inserted at least partially into an eye; a carrier member (105) with a shell (101) having a central channel (103) extending at least partially through the shell from a proximal end (108) towards a distal end of the shell. A guide sleeve (120) removably attached within at least a first region of the central channel of the shell and defining a proximal port (113) into the central channel that is accessible from the proximal end of the shell. An implant holder (125) removably attached within at least a second region of the central channel of the shell adjacent to a distal end of the guide sleeve and having a pair of graspers adapted to releasably secure the implant (110) at a distal end of the implant holder. Related devices, systems, and/or methods are described.   Figure 2A
Patent MY-182318-A (MY)
Title: Phenyl tetrahydroisoquinoline compound substituted with heteroaryl
Inventor: SHOICHI KURODA
IPC: C07D401/10
Filed: 2015-07-24
Abstract: The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3 inhibitory effect: [Formula 15]  A-Y [l] wherein A represents a structure represented by the following formula [2]:  [Formula 16]  wherein R11 and R12 each represent a halogen atom or the like,  R2 represents C1-6 alkyl or the like, ring E represents triazole, tetrazole, pyrimidine, or the like, R31 and R32 each represent a hydrogen atom, Ct-6 alkyl, Ct-6 alkoxy, or the like, and W represents a single bond, the formula -NH-, the formula -0-, or the formula -CONH-, and Y represents a hydrogen atom or a structure represented by the following formula [3']:  [Formula 17]
Patent MY-177587-A (MY)
Title: Multivalent vlp conjugates
Inventor: KAPRE SUBHASH V
Filed: 2016-09-12
Abstract: The invention is directed to vaccines comprising capsular polysaccharides conjugated to one or more components of virus like particles (VLP), and methods for the administration of and methods for the manufacture of vaccines of the invention. Preferably vaccines of the invention generate a therapeutically effective response in an individual in need thereof to multiple strains and/or serotypes of the same or of different infectious agents. Preferably such vaccines generate a therapeutically effective immune response to all pathogenic strains and/or serotypes of the same infectious agent. In particular, the invention is directed to methods and compositions for the cost efficient administration of a vaccine to a patient in need thereof exposing the patient?s immune system to only the immunogenic components that are likely to be beneficial for the generation of a protective immunological response, both efficacy and safety are increased and cost effectively.
Patent MY-198123-A (MY)
Title: A heat transfer sheet assembly with an intermediate spacing feature
Inventor: YOWELL JEFFERY E
IPC: F28D19/04
Filed: 2017-04-10
Abstract: A heat transfer sheet assembly (7) for a rotary regenerative heat exchanger, has first and second heat transfer sheet elements (8, 9) stacked one against the other with a first repeat R1 of a first profile on one sheet element (8) opposing a second repeat R2 of a second profile on the other sheet element (9). The sheet elements (8, 9) are spaced apart by a plurality of wide-gauged parallel sheet spacing features (21, 22) of the first profile repeat R1 and (23, 24) of the second profile repeat R2 to form a generally close sided elongate channel (25) for gaseous flow therethrough. The second profile of repeat R2 further comprises an elongate fifth sheet spacing feature (26) in the form of a lobe contacting undulations (29) of the adjacent first profile of repeat R1. In an embodiment, the first and second sheet elements each have a composite third profile including both the first repeat of the first profile and the second repeat of the second profile.
Patent MY-197337-A (MY)
Title: Tube-in-tube pull-out faucet
Inventor: WEIXIN HUANG
IPC: E03C1/04
Filed: 2018-12-03
Abstract: The invention provides a tube-in-tube pull-out faucet which comprises a faucet body (1) and an outer tube (2) fixed to the faucet body (1), and further comprises a tube-in- tube pull-out device (3) located above the faucet body (1), wherein the tube pull-out device comprises an inner tube joint (31), an inner tube joint nut (32), an inner tube (33), a first spring bracket (34), a first pull-out tube joint (35), a pull-out tube (36) and a telescopic spring (37) which are disposed in a cavity of the outer tube (2), one end of the inner tube joint (31) is sleeved on the faucet body (1) or the outer tube (2) and the other end thereof is screwed to the inner tube joint nut (32), the inner tube joint (31) is provided with an integrally formed joint portion, and an outer side wall of the joint portion is in sliding fit with an inner side wall of one end of the inner tube (33). Compared with the prior art, the invention can reduce the interference with many parts or even difficulty in pulling due to the tube-in-tube pull-out device disposed above the faucet body (1), has the advantages of convenience and smoothness in pull-out and low cost, can be conveniently and quickly replaced after sale, can be rotated by 360?, and is convenient to use.
Patent SG-10201810251S-A (SG)
Title: Method for permanent connection of two metal surfaces
Inventor: WIMPLINGER MARKUS
Filed: 2011-02-23
Abstract: No Available Figure]
Patent SG-10201906501Y-A (SG)
Title: 21-hydroxylation of steroids
Inventor: LATTEMANN CLAUS
Filed: 2015-10-29
Abstract: 21-Hydroxylation of steroids : 5 Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells. 10 [Figure no. 2]
Patent SG-11201407604W-A (SG)
Title: Working device energy recovery system
Inventor: HE QINGHUA
IPC: F15B21/14
Filed: 2013-05-17
Abstract: (i2) (19) mm m ran=/ ..,_, (10) mwm* (43) gR^^H 2013 11 ft 28 0 (28.11.2013) WIPO I PCT WO 2013/174235 A1 E02F 9/22 (2006.01) PCT/CN2013/075812 2013^5^17 0 (17.05.2013) ^y: (51) F1SB 21/14 (2006.01) B66F 9/22 (2006.01) (21) Hfictflflf#: (22) (25) Ifff: (26) (30) 201220232536.2 2012^5 M 22 0 (22.05.2012) CN (71) (SUNWARD INTELLIGENT EQUIPMENT CO., LTD) [CN/CN]; ^ fi^i5$Fi£7fv;FF 16 ^r, Hunan 410100 (CN) = (72) (HK, Qinghua); tlWill fl Ixi^il/ 16 \"f, Hunan 410100 (CN) = (TANG, Zhongyong); ^ S M if itis: 4^ 16 \"f, Hunan 410100 (CN) = (ZHANG, Daqing); ^ flT fi fp in $F ££ 7fvjF Jx. E JSi 4 1 16 -^, Hunan 410100 (CN) o (ZHANG, Yunlong); 4^ HI Si if ^ is: T)T fi in M Jf E M M 4^ i?4 16 ^ , Hunan 410100 (CN) o (WANG, Jingang); 4^ Sffllf 16^, Hunan 410100 (CN) = mm (CHEN, Han); 4^ Sffllf fi^5^K^^^E?Si#@ 4^ 16 ^r, Hunan 410100 (CN) = (74) ftSA:(RONGZHI PAT­ ENT AGENCY); 4^ S M if it $& 308 ^r, Hunan 410011 (CN) = (8D I)''): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, (54) Title: ENERGY RECYCLING SYSTEM FOR WORKING DEVICE (54) : ximmmmmm m CJ •t i> i-H cn i-H o CJ o & I FIG. 1 5 LOGIC CONTROL UNIT (57) Abstract: An energy recycling system for a working device comprises an energy converter, pressure-retaining a valve, switch­ a ing valve, an energy collector, a logic control unit, a main valve, a movable arm device and corresponding connecting components. By using this system, the potential energy generated during the lowering of the movable arm device can be controllably converted into hy­ draulic energy to be stored in the energy collector, and the potential energy can also be directly recycled for acting on the movable arm device in balancing mode. The a heat generated by the hydraulic sys­ tem thereby reduced, the is input power of prime motor a is reduced, and the purpose of saving energy achieved. is (57) — f+IfN 6b J Fits J Bum WO 2013/174235 A11 lllll llllllll II llllll III lllll lllll lllll III III III lllll llll llll lllll lllll lllll lllllll llll llll LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW = (84) UP): ARIPO (BW, GM, KE, GH, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), (AM, AZ, BY, KG, KZ, RU, TJ, TM), (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)o - 21 &(3»=
Patent SG-11201805682W-A (SG)
Title: Method and device for producing planar modifications in solid bodies
Inventor: RIESKE RALF
IPC: B28D1/22
Filed: 2016-12-12
Abstract: The present invention relates to a method for creating modifications in a solid state, wherein a crack guidance region for guiding a crack for separating a solid-state portion, in particular a solid-state layer, from the solid state body, is predetermined by the modifications. The method according to the invention preferably comprises the steps: Moving the solid state () relative to a laser processing system, then generating a plurality of laser beams by means of the laser processing system for creating at least one modification, wherein the laser processing system is adjusted for defined focusing of the laser beams continuously as a function of a plurality of parameters, in particular at least two parameters. (Fig. 1) 40
Patent SG-11201809169P-A (SG)
Title: Harq-ack multiplexing in pusch
Inventor: KOORAPATY HAVISH
IPC: H04L5/00
Filed: 2017-05-12
Abstract: Oneresource element O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 November 2017 (16.11.2017) WIPO I PCT omit VIII mum 0 VIII VIII VIII o iflo oimIE (10) International Publication Number WO 2017/195168 Al (51) International Patent Classification: H04L 1/18 (2006.01) HO4L 1/00 (2006.01) H04L 5/00 (2006.01) (21) International Application Number: PCT/IB2017/052809 (22) International Filing Date: 12 May 2017 (12.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/336,116 13 May 2016 (13.05.2016) US (72) Inventors: KOORAPATY, Havish; 13425 Kodiac Place, Saratoga, 95070 (US). CHENG, Jung-fu; 1806 Mandan Place, Fremont, 94539 (US). CAPAR, Cagatay; Toros Mah. 78041 Sok. No: 5, Hamide Hanim Apt. Kat: 4, Daire: 5, 01170 Cukurova/ADANA (TR). (74) Agent: WESTOVER, Ben et al.; 6300 Legacy Drive, M/S EVR 1-C-11, Plano, Texas 75024 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (71) Applicant: TELEFONAKTIEBOLAGET LM (84) ERICSSON (PUBL) [SE/SE]; SE-164 83, SE-164 83 Stockholm (SE). (54) Title: HARQ-ACK MULTIPLEXING IN PUSCH 4 One OFDM symbol including cyclic prefix FIGURE 1 (57) : A method of operating a wireless communication device comprises channel coding Channel State Information (CSI) bits jointly with Hybrid Automatic Repeat Request (HARQ) Acknowledgement (HARQ-ACK) bits, multiplexing the jointly coded CSI and HARQ-ACK bits with coded data bits, and transmitting the multiplexed coded CSI and HARQ-ACK bits and coded data bits on a physical uplink shared channel (PUSCH). [Continued on next page] WO 2017/195168 Al MIDEDIM01101 DIDIRMEM111111111111111H11111H1101111111111111111111 Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
Patent SG-11201810022X-A (SG)
Title: Plant regulatory elements and uses thereof
Inventor: CHITTOOR JAISHREE
IPC: C12N15/11
Filed: 2017-05-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101/110 111010101111101011111 0 011111111111111111111111111111111111111111111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/205287 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: AO1H 5/00 (2006.01) C12N 15/11 (2006.01) AO1H 5/10 (2006.01) C12N 15/113 (2010.01) C12N 5/10 (2006.01) C12N 15/82 (2006.01) (21) International Application Number: PCT/US2017/033832 (22) International Filing Date: 22 May 2017 (22.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/340,656 24 May 2016 (24.05.2016) US (71) Applicant: MONSANTO TECHNOLOGY LLC [US/US]; 800 North Lindbergh Blvd., Mail Zone E1NA, St. Louis, MT 63167 (US). (72) Inventors: CHITTOOR, Jaishree, M.; 800 North Lind- — bergh Blvd., St. Louis, MO 63167 (US). FLASINSKI, Stanislaw; 800 North Lindbergh Blvd., St. Louis, MO — 63167 (US). = Agent: HANSON, Robert, E.; P.O. Box 061080, Wacker = (74) Drive Station, Willis Tower, Chicago, IL 60606 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (81) _ = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, — = KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = = SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = — 1-1 .•!! Published: it .„ with international search report (Art. 21(3)) pc — ei with sequence listing part of description (Rule 5.2(a)) kr) 0 ! (54) Title: PLANT REGULATORY ELEMENTS AND USES THEREOF IN ,-1 (57) : The invention provides recombinant DNA molecules and constructs, as well as their nucleotide sequences, useful for 0 modulating gene expression in plants. The invention also provides transgenic plants, plant cells, plant parts, and seeds comprising the \" recombinant DNA molecules operably linked to heterologous transcribable DNA molecules, as are methods of their use.
Patent SG-11201811654T-A (SG)
Title: Method and system for the real-time calculation of the amount of energy transported in a non-refrigerated, pressurised, liquefied natural gas tank
Inventor: BEN BELGACEM-STREK MICHEL
IPC: F17C13/02
Filed: 2017-06-14
Abstract: Method and system for the real-time calculation of the amount of energy transported in a non-refrigerated, pressurised, liquefied natural gas tank. The present invention relates to a method and system for 5 the real-time calculation of the amount of residual chemical energy in a non-refrigerated, pressurised tank containing liquefied natural gas (LNG), without the composition of the LNG having to be determined. 10 FIG. 6
Patent SG-11201903884W-A (SG)
Title: Signal transmission method, terminal device, and network device
Inventor: LIN YANAN
IPC: H04W72/04
Filed: 2016-11-03
Abstract: Disclosed in embodiments of the present invention are a signal transmission method, a 5 network device, and a terminal device. The method comprises: sending indication information to a first terminal device, the indication information being used for indicating a resource region used for receiving a downlink control signal by the first terminal device; and sending the downlink control signal to the first terminal device in the resource region. By means of the method, the network device and the terminal device in the embodiments of the present invention, 10 system performance can be improved, and energy consumption of the terminal device can be reduced. FIG. 2
Patent SG-11201908196S-A (SG)
Title: Tubular clamp system
Inventor: RIOS ROGELIO
IPC: E21B19/16
Filed: 2018-02-07
Abstract: WO 18/ 16 47 99 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIP0 I PCT °Ens °nolo Oil100HoIIIII001 Oilo iflo oimIE (10) International Publication Number WO 2018/164799 Al (51) International Patent Classification: E21B 19/16 (2006.01) (21) International Application Number: PCT/US2018/017253 (22) International Filing Date: 07 February 2018 (07.02.2018) English English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (25) Filing Language: (26) Publication Language: (30) Priority Data: 15/453,629 08 March 2017 (08.03.2017) US (84) (71) Applicant: FORUM US, INC. [US/US]; 920 Memorial City Way, Suite 1000 , Houston, Texas 77024 (US). (72) Inventor: RIOS, Rogelio; 22310 Ebbets Field Dr., Spring, Texas 77389 (US). (74) Agent: PATTERSON, B. Todd et al.; PATTERSON + SHERIDAN LLP, 24 Greenway Plaza, Suite 1600, Hous- ton, Texas 77046 (US). (54) Title: TUBULAR CLAMP SYSTEM 100 Fig. 1 (57) : A tubular clamp system (100) comprising a carriage assembly (205) coupled to a gripper assembly (200). The gripper assembly includes a pair of jaws (215) movable into engagement with a tubular by a lead screw (520) that is rotated by a first actuator (210). The pair of jaws (215) are configured to grip and lift the tubular by a thrust nut (535) that is coupled to the lead screw (520) and is rotatable by a second actuator (405). [Continued on next page] WO 2018/164799 Al MIDEDIMOMMIDIREEMOMOHINHOEHOHOMEEN Published: — with international search report (Art. 21(3))
Patent SG-11201909735Y-A (SG)
Title: Therapeutic compounds and compositions, and methods of use thereof
Inventor: ZAK MARK
IPC: C07D487/04
Filed: 2018-05-21
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 November 2018 (29.11.2018) WIPO I PCT mu °mons ono o VI IIIII onll oil Eno iflo oimIE (10) International Publication Number WO 2018/215389 Al (51) International Patent Classification: CO7D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: (22) International Filing Date: PCT/EP2018/063262 Published: — with international search report (Art. 21(3)) 21 May 2018 (21.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2017/085276 22 May 2017 (22.05.2017) CN 62/640,865 09 March 2018 (09.03.2018) US (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant (for US only): GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, California 94080 (US). (72) Inventors: ZAK, Mark; c/o Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080 (US). ROMERO, F. An- thony; 3280 Bayshore Boulevard, Brisbane, CA 94005 (US). CHENG, Yun-Xing; 6 Tai-he Road, BDA, Beijing 100176 (CN). (74) Agent: SCHIRLIN, Julien; Grenzacherstrasse 124, 4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 1-1 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 00 11 el (54) Title: THERAPEUTIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF USE THEREOF (57) : Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharma- O ceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of \" treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.