Patent SG-11201908954Q-A (SG)
Title: A method of preparing silica nanocapsules and silica nanocapsules
Inventor: PARK EUN JU
IPC: A61K47/02
Filed: 2018-03-28
Abstract: 00 00 O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT onion °nolo onoiol °nom° oimIE (10) International Publication Number WO 2018/182518 Al (51) International Patent Classification: BO1J 13/02 (2006.01) CO1B 33/14 (2006.01) A61K 9/51 (2006.01) B82Y 5/00 (2011.01) A61K 47/02 (2006.01) (21) International Application Number: PCT/SG2018/050147 (22) International Filing Date: 28 March 2018 (28.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201702634U 30 March 2017 (30.03.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10, Connexis North Tower, Singapore 138632 (SG). (72) Inventors: PARK, Eun Ju; c/o Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, Sin- gapore 627833 (SG). M. VAN HERK, Alexander; c/o Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore 627833 (SG). THONIY- OT, Praveen; c/o Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore 627833 (SG). (74) Agent: DONALDSON & BURKINSHAW LLP; 24 Raf- fles Place, #15-00 Clifford Centre, Singapore 048621 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (54) Title: A METHOD OF PREPARING SILICA NANOCAPSULES AND SILICA NANOCAPSULES 200 FIG. 13 (57) : There is provided a method of preparing silica nanocapsules, the method comprising mixing a surfactant with water at a temperature that is above the gel-to-liquid transition temperature of the surfactant to form a mixture, passing the mixture one or more times through at least one pore to obtain a dispersion of vesicles, and adding a silica precursor to the dispersion of vesicles to form silica nanocapsules. Also provided is a silica nanocapsule formed from a vesicle template, and a method of delivering one or more types of molecules to a subject. In a specific embodiment, hollow silica nanocapsules having substantially lens-shaped are synthesized by employing dimethyldioctadecylammonium bromide (DODAB) or dioctadecyldimethyl ammonium chloride (DODAC) as the vesicle template and tetraethyl orthosilicate (TEOS) as the silica precursor. [Continued on next page] WO 2018/182518 Al MIDEDIM01101 DIONER131110111111111111101111111111111111111 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))