baber/WOPTO huggingface dataset:
Patent FI-951130-A0 (FI)
Inventor: BREIPOHL GERHARD
IPC: C07D239/46
Filed: 1995-03-10
Abstract: A process is claimed for preparing peptide nucleic acid (PNA) oligomers of formula (I) B-X = a gp. of formula (i)-(viii): f = 1-4; g = 0-3; Ro = H, 1-18C alkanoyl, 2-19C alkoxycarbonyl, 3-8C cycloalkanoyl (sic), 7-15C aroyl, 3-13C heteroaroyl or a gp. which enhances intracellular uptake of the oligomer or interacts with a target nucleic acid during hybridisation; A and Q = amino acid residues; k and m = 0-10; B = a natural or non-natural nucleotide base, opt. in prodrug form, or a base substitute; Qo = OH, NH2 or NHR"; R" = 1-18C alkyl, 2-18C aminoalkyl or 2-18C hydroxyalkyl; n = 1-50. The process comprises: (a) opt. coupling amino acids (Q<1>) to a support of formula L-(Polymer) by solid-phase synthesis, where L = a linking gp. contg. Qo in latent form and Q<1> = Q with optional side-chain protecting; (b) opt. removing the protecting gp. PG (sic) with a suitable reagent; (c) repeating steps (a) and (b) m-1 times to give (Q<1>)m-L-(Polymer); (d) coupling a cpd. of formula (II) to L-(Polymer) or (Q<1>)m-L-(Polymer): PG-X(B<1>)-OH (II) where PG is a weak-acid-labile protecting gp. and B<1> is B with opt. protected exocyclic amino or OH gps.; (e) removing PG; (f) repeating steps (d) and (e) n-1 times; (g) opt. coupling amino acids (A<1>) to the prod. by solid-phase synthesis, where A<1>=A with optional side-chain protection; (h) removing the protecting gp. PG (sic) with a suitable reagent; (i) repeating steps (g) and (h) k-1 times; (j) introducing Ro if Ro is other than H; and (k) cleaving the PNA oligomer from the prod. of formula (III) and simultaneously or subsequently deprotecting B<1>, A<1> and Q<1>: Ro-(A<1>)k-(X(B<1>))n-(Q<1>)m-L-(Polymer) (III).
Patent FI-963174-A0 (FI)
Inventor: UPASANI RAVINDRA B
IPC: C07J7/00
Filed: 1996-08-13
Abstract: Methods, compositions and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
Patent FI-972455-A0 (FI)
Inventor: SAIRANEN MARTTI
IPC: H03K17/082
Filed: 1997-06-10
Abstract: PCT No. PCT/FI98/00495 Sec. 371 Date Mar. 31, 1999 Sec. 102(e) Date Mar. 31, 1999 PCT Filed Jun. 9, 1998 PCT Pub. No. WO98/59421 PCT Pub. Date Dec. 30, 1998A power control (20, 40) for controlling the electric power fed from voltage source (12) to a load (13) comprises a field effect transistor (21, Q1) for either allowing or disabling the flow of current from voltage source to load as a response to the presence or absence of a control pulse led to the gate of the field effect transistor. Additionally the power control comprises means for measuring the change of the gate potential of the field effect transistor (24, R6, R7) and for either allowing or disabling a control pulse on the basis of the gate potential change measurement. In the power control the control pulse is allowed to switch the field effect transistor (21, Q1) to conducting state when a stop (31) in the voltage increase due to Miller effect is detected at the start of the control pulse, and the control pulse is respectively disabled from switching the field effect transistor to conducting state when no Miller effect stop (33) is detected in the field effect transistor gate potential change at the start of the control pulse.
Patent AP-9400645-A0 (AP)
Title: Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release sold dosage forms of medicaments prepared thereby.
Inventor: PALEPU NAGESWARA R
IPC: A61K9/20
Filed: 1994-05-26
Abstract: Invented is a process for preparing controlled release formulations
Patent AP-9701004-A0 (AP)
Title: Low molecular weight bicyclic thrombin inhibitors.
Inventor: GILLARD JOHN
IPC: C07D513/04
Filed: 1995-12-21
Abstract: This invention relates to the discovery of heterocyclic competitive inhibitors of the enzyme thrombin having formula (i), their preparation and pharmaceutical compositions thereof. As well, this invention relates to the use of such compounds and compositions in vitro as anticoagulants and in vivo as agents for the treatment and prophylaxis of thrombotic disorders such as venous thrombosis, pulmonary embolism and arterial thrombosis resulting in acute ischemic events such as myocardial infarction or cerebral infarction. Moreover, these compounds and compositions have therapeutic utility for the prevention and treatment of coagulopathies associated with coronary bypass operations as well as restenotic events following transluminal angioplasty.
Patent IL-59394-A0 (IL)
Title: Positive active material for an electric cell with a non-aqueous electrolyte,and its preparation
IPC: H01M4/58
Filed: 1980-02-15
Abstract: The invention relates to a positive active material for an electric cell with a non-aqueous electrolyte. Said active material is constituted by an oxyphosphate whose formula is CunOp(PO4)2,n being an integer greater than 3 and lower than or equal to 6 and p being equal to n-3. Application to lithium primary cells.
Patent IL-71228-A0 (IL)
Title: Carbon molecular sieves,their preparation and their use
IPC: B01D53/02
Filed: 1984-03-13
Abstract: The instant invention is directed to a molecular sieve comprising a carbonaceous substrate impregnated with an organic polymer having a molecular weight of at least 400, as determined by vapor phase osmometry, or with an inorganic polymer at a dosage of at least 0.001 weight percent (based on the substrate weight) up to a maximum dosage which still allows the resulting sieve to separate gas or liquid mixtures containing components of at least two different molecular diameters, molecular weights or molecular shapes.The instant invention is also directed to a process for preparing a molecular sieve which comprises impregnating a carbonaceous substrate with an inorganic polymer having a molecular weight of at least 400, as determined by vapor phase osmometry, or with an inorganic polymer at a dosage of at least 0.001 weight percent (based on the substrate weight) up to a maximum dosage which still allows the resulting sieve to separate gas or liquid mixtures containing components of at least two different molecular diameters, molecular weights or molecular shapes.The instant invention is also directed to a process for separating gas or liquid mixtures containing components of at least two different molecular diameters, molecular weights or molecular shapes, comprising passing the liquid or gas through a molecular sieve comprising a carbonaceous substrate impregnated with an organic polymer having a molecular weight of at least 400, as determined by vapor phase osmometry, or with an inorganic polymer at a dosage of at least 0.001 weight percent (based on the substrate weight) up to a maximum dosage which still allows the resulting sieve to separate gas or liquid mixtures containing components of at least two different molecular diameters, molecular weights or molecular shapes.
Patent IL-78773-A0 (IL)
Title: 2-(4-benzoyl-1-piperidyl)-1-phenylalkanol derivatives
IPC: C07C233/33
Filed: 1986-05-13
Abstract: Compound of general formula I    <IMAGE>  (I)  in which R is hydrogen, R1 is unsubstituted phenyl, 4-methoxy - 3,5-dimethylphenyl or phenyl substituted at one of the 2-, 3- or 4- positions by halogen, C1-4 alkyl, C1-4 alkoxy, hydroxy, benzyloxy, trifluoromethyl, cyano, nitro, amino, acetylamino, methylthio, methylsulphonyl or aminosulphonyl and R2 is unsubstituted phenyl, 2,4,6-trimethoxyphenyl or phenyl substituted at either the 3- or the 4- positions by fluorine, chlorine, methyl or methoxy, or an acid addition salt thereof.
Patent IL-83842-A0 (IL)
Title: Benzo-fused cycloalkane and exa-and thia-,cycloalkane trans-1,2-diamine derivatives,their preparation and pharmaceutical compositions containing them
IPC: A61K31/495
Filed: 1987-09-09
Abstract: Benzo-fused cycloalkane and oxa- and thiacycloalkane trans-1,2-diamine compounds of the formula: <CHEM> wherein A, B, C, D, n, X, Y, R, R<1>, R<2> and R<3> are as defined in the specification, e.g., trans-3,4-dichloro-N-methyl-N-[2-(pyrrolidin-1-yl)-5-methoxy 1,2,3,4-tetrahydronaphth-1-yl]benzeneacetamide, and the pharmaceutically acceptable salts or N-oxides thereof, are useful as analgesics and/or diuretics.
Patent FI-20010831-A0 (FI)
Inventor: SYVAENNE TUOMO
IPC: H04L29/06
Filed: 2001-04-23
Abstract: The present invention relates to a method of managing a network device, a network device, and a management system. A configuration of a firewall is changed over a network connection by a remote management system (10). The firewall (11) applies the change configuration after receiving a command from the management system (10). Shortly after the changed configuration is applied, the management system (10) takes a new connection to the firewall (11). With this new connection, the configuration is accepted for permanent use in the firewall (11). If a new connection is not successfully set-up within a given time limit, the firewall (11) will automatically return to use the old configuration. Thereby, the firewall (11) is able to restore from any loss of management connection caused by a mistake in the changed configuration. <IMAGE>
Patent FI-20012128-A0 (FI)
Inventor: HILLIAHO ERKKI
IPC: E06B7/23
Filed: 2001-11-05
Abstract: Sealing structure for a glazing system that comprises a fastening profile 4 for fastening glass panes 1 and a guide profile 2 for guide members, wherein said profiles 2, 4 are placed on top of each other, and said guide members, in turn, are arranged to move and fasten to said fastening profile. The sealing structure comprises a first sealing 9 that is fastened to the guide profile 2, and a second sealing 6 that is fastened to the fastening profile 4. Each said sealing 6, 9 comprises a first wall 6a, 9a extending from each profile 2, 4 towards the opposite profile, and a second profile 6b, 9b that is fastened to the first wall and positioned between each profile 2, 4 and the first wall of the opposite sealing, wherein the first walls 6a, 9a are positioned within a distance from each other, thus allowing the deviations of the profiles, wherein also the second walls 6b, 9b are positioned within a distance from each other, thus allowing the changes in the distance between the profiles 2, 4.
Patent FI-20030263-A0 (FI)
Inventor: KOSKIMAEKI ANTTI
IPC: B25D9/20
Filed: 2003-02-21
Abstract: The invention relates to a control valve, a percussion device and a method of controlling a working cycle of a percussion device. A percussion device ( 1 ) for breaking rock includes an impact element ( 8 ) controlled by a control valve ( 2 ). The control valve includes a control element ( 5 ) arranged to control channels ( 7 b) leading to a working pressure surface ( 9 ) of the impact element ( 8 ). The control element, during a working cycle of the control valve, is arranged to open and close pressure channels at several connecting moments so that during one working cycle of the valve, several impact pulses are arranged to be produced.
Patent FI-20030906-A0 (FI)
Inventor: NAATTI ILKKA
IPC: B65H18/22
Filed: 2003-06-17
Abstract: Before a reel change a new core ( 5 ) is brought to a change station. When the old reel (R) is full, the web is changed to travel to the new core periphery and primary reeling beings. The web forms a reel through a reeling nip (N 1 ) between the loop of an endless supporting member ( 1 ) and the core. A change is made to secondary reeling, where a portion of the supporting member ( 1 ) brings the web to the reel, to move over to the reel in a nip (N) between said portion and the reel outer periphery. The core ( 5 ) is transferred so the nip (N) moves forward. A first guide roll ( 2 ) is transferred towards the core periphery so the distance of the nip (N 1 ) located between the core ( 5 ) and the loop of the supporting member ( 1 ) from the first guide roll ( 2 ) changes in the primary reeling.
Patent FI-20086012-A0 (FI)
Inventor: ROENNLUND IDA
IPC: C02F/
Filed: 2008-10-24
Abstract: A method, apparatus and use for hydrothermal treatment of organic material. The method comprising steps of: obtaining a reaction mixture comprising said organic material, and an enhancing additive, and reacting said reaction mixture in supercritical or near-critical state of water, wherein black liquor is used as said enhancing additive for obtaining said reaction mixture.
Patent FI-20115853-A0 (FI)
Inventor: MAULA JARMO
IPC: B01D50/00
Filed: 2011-08-31
Abstract: The invention relates to a filter preunit for chemical vapour deposition processes. The unit is used to remove reaction residues from a residual gas flow. The filtering unit comprises at least two contact surfaces (24a, 24b), in connection of which the residual gas flow and reagent flow come into contact with each other, with at least one of the contact surfaces (24a, 24b) being movable to purify the contact surfaces from reaction residues grown on them.
Patent IL-101560-A0 (IL)
Title: Condensed diazepinones,their preparation and pharmaceutical compositions containing them
IPC: C07D495/04
Filed: 1992-04-10
Abstract: The invention relates to novel condensed diazepinones of the general formula I <IMAGE>  in which     B represents one of the divalent radicals <IMAGE> and   X, l, m, n and R<1> to R<7> are as defined in Claim 1, and in addition to their salts with inorganic or organic acids and a process for their preparation. The substances are used to improve or normalise disorders of cerebral perfusion due to arteriosclerosis, to treat diseases of the central nervous system, in particular Alzheimer's disease and Parkinson's disease, and as vagal pacemakers for the treatment of bradycardias and bradyarrhythmias, and also for improving memory power.
Patent IL-106128-A0 (IL)
Title: Vitamin d derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IPC: A61P35/02
Filed: 1993-06-24
Abstract: The invention relates to vitamin D derivatives, modified in 20-position, of general formula I    <IMAGE>  I  in which X, Y, Z, R1, R2 as well as R3 have the meaning indicated in the description, process for their production and their use as agents for treatment of hyperproliferative diseases of the skin.
Patent IL-118491-A0 (IL)
Title: Use of pyrrolidine derivatives in the treatment of alcoholism
IPC: A61K31/425
Filed: 1996-05-30
Abstract: PCT No. PCT/FR96/00801 Sec. 371 Date Nov. 26, 1997 Sec. 102(e) Date Nov. 26, 1997 PCT Filed May 29, 1996 PCT Pub. No. WO96/38139 PCT Pub. Date Dec. 5, 1996The use of pyrrolidine derivatives of general formula (I) for treating chronic alcoholism or conditions caused by alcohol abuse is described.
Patent IL-146020-A0 (IL)
Title: Stent device and method for treating glaucoma
IPC: A61F2/00
Filed: 2000-04-26
Abstract: The present invention relates to a shunt adapted to facilitate the passage of aqueous humor from the anterior chamber to Schlemm's canal, comprising: a body of biocompatible material having a size and shape adapted to be at least partially circumferentially received within a portion of Schlemm's canal to divert aqueous humor from the anterior chamber of the human eye to and within Schlemm's canal; the body comprising a distal portion and a proximal portion; wherein the body defines a trough-like channel that is at least partially open for directing aqueous humor; and wherein the body is adapted, when in use, to facilitate the passage of aqueous humor from the anterior chamber into Schlemm's canal without the proximal portion extending into the anterior chamber.
Patent IL-156159-A0 (IL)
Title: High efficiency heater and stripper
IPC: G02B6/00
Filed: 2001-11-27
Abstract: A system for stripping an optical fiber includes a source of air, and a means for generating very short bursts of air. The heater (100) includes a heater core that includes a heat generating element and a heat chamber (114) enclosed within the heater core. A spiral-shaped air conduit (116) surrounds the outer surface of the heater core, and communicates with the heat chamber. Upon injection of air into the conduit, heat is transferred to the air from the heat generating element while the air flows through the air conduit and into and out of the chamber through outlet port (201).
Patent IL-156508-A0 (IL)
Title: Sub-channels for the random access channel in time division duplex
IPC: H04W74/08
Filed: 2001-12-13
Abstract: Sub-channels are defined for a physical random access channel of a wireless time division duplex communication system using code division multiple access. The sub-channels carry information between system users and a system network. A series of radio frames have a sequence of timeslots. For a particular timeslot number of the sequence, each sub-channel of the particular timeslot number is uniquely defined by one radio frame of the series.
Patent IL-160141-A0 (IL)
Title: Novel molecular target for neurotoxicity
IPC: A61P25/16
Filed: 2002-08-13
Abstract: Detecting excitotoxicity and neuronal stress in a subject comprises in vitro measurement of phosphodiesterase-4 (PDE4), particularly PDE4B, or detecting the presence of a mutant form of the mRNA for PDE4B, particularly a form that lacks all or part of the 3'-non-coding region. Independent claims are also included for the following: (1) Use of a compound (A) that inhibits or reduces expression or activity of PDE4B for treatment of neurodegenerative diseases; (2) Primers (B) containing 8-20 consecutive residues from the nucleotide region 2384-2869 of a murine PDE4B sequence (S1) or 2461-4068 of a human PDE4B sequence; and (3) Kits for analyzing expression of PDE4. ACTIVITY : Nootropic; Neuroprotective; Antiparkinsonian; Anticonvulsant; Cerebroprotective. Granular neurons from the cerebellum of rats were treated with N-methyl-D-aspartate (i) and serine or kainate (ii), to stimulate excititoxicity. When this treatment was carried out in presence of 50 M pentoxifylline, toxicity was reduced from about 40 to 20% in (i) and from about 30 to 10% in (ii). MECHANISM OF ACTION : Inhibiting expression or activity of PDE4B, which is present at elevated level in pathological nerve tissue.
Patent IL-162429-A0 (IL)
Title: Isolation tool for viable c-kit expressing cells
IPC: C12N15/90
Filed: 2002-12-12
Abstract: A tool for the isolation of c-kit expressing cells is provided. This tool consists of a c-kit plasmid targeting vector which is capable of integrating into the wild type c-kit allele and encodes a chimeric fluorescent protein comprising a nucleolar localization signal such as, TCOF-1<SUP>2</SUP>, RLP31<SUP>3</SUP>, RPS25<SUP>4 </SUP>or Fxr2h<SUP>5</SUP>. The construct generates a condensed, bright, fluorescent signal that can be localized in living tissue and after dissociation. The construct allows visualization using confocal microscopy and allows automated cell sorting of the dissociated cells using amongst others flow cytometry.
Patent IL-164300-A0 (IL)
Title: Method for coating metal surfaces and substrate having a coated metal surface
IPC: G02B3/00
Filed: 2004-09-27
Abstract: A process for producing a coated substrate or a product having a coated substrate is provided. The process includes coating at least one metallic surface with a glass, the substrate being coated with an evaporation-coating glass at least on the metallic surface.
Patent IL-173423-A0 (IL)
Title: Method, system and program product for asynchronously processing requests
IPC: H04L29/06
Filed: 2006-01-30
Abstract: Under the present invention, a request for a Uniform Resource Locator (URL) is received from a client on a server. Upon receipt, a corresponding session object is obtained, and a response identifier is generated. Based on the response identifier, it is determined whether the URL was previously requested by the client. If not, generation of a final response begins. As the response is being generated, a response refresh header is generated and returned to the client with a temporary response. The response refresh header contains a time value for causing the client to automatically send a subsequent request for the URL. After generation of the final response is complete, it is stored in a cache according to the response identifier. Then, when the subsequent request is received from the client, the final response is retrieved from the cache and served to the client.
Patent IL-182620-A0 (IL)
Title: Display for public use
Filed: 2007-04-17
Abstract: In a basic embodiment of a display for public use including a stand, an internal computer and an internal air conditioning system, the computer (10) is arranged according to the invention inside a housing (7) of the display, an evaporator (1) of an air conditioning device acting as an air delivering member is connected from below to an opening (18) in the floor panel of the housing (7) of the display, with said device being arranged inside the hollow stand (8) of the display, while a compressor (2) of the air conditioning device acting as a member for drawing in air is arranged on the floor panel of the stand (8). Modifications of said solution refer to standless displays providing the equipment either entirely in the housing of the display or entirely outside the housing of the display or partly inside partly outside.
Patent IL-186832-A0 (IL)
Title: Process for the preparation of a carboxamide derivatives
Filed: 2007-10-22
Abstract: Process for the preparation of a carboxamide derivative of general formula (I) or a salt thereof   
Intermediates for preparing this compound.
Patent IL-189490-A0 (IL)
Title: Modulators of metabolism and the treatment of disorders related thereto
Filed: 2008-02-12
Abstract: The present invention relates to 4-[5-methyl-6-(2-methyl-pyridin-3-yloxy)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity.
Patent IL-193569-A0 (IL)
Title: Magnesium-based alloy with improved combination of mechanical and corrosion characteristics
Filed: 2008-08-20
Abstract: Multi-component magnesium-based alloy consisting essentially of about 1.0-15.0 wt. % of scandium, about 0.1-3.0 wt. % of yttrium, about 1.0-3.0 wt. % of rare-earth metal, about 0.1-0.5 wt. % of zirconium. Purity degree of magnesium base is not less of 99.995 wt. %. Impurities of Fe, Ni and Cu do not exceed 0.001 wt. % of everyone, the contents of other impurity in an alloy does not exceed 0.005 wt. %. The alloy demonstrates an improved combination of strength, deformability and corrosion resistance at room temperature. The alloy does not contain harmful and toxic impurities. The alloy can be used in the various practical applications demanding a combination of high strength, deformability and corrosion resistance, preferably in the field of medicine.
Patent RO-129093-A0 (RO)
Title: Ecologic liquid glycerin-emulsified furnace fuels and process for preparing the same
Inventor: BOMBOS DORIN
IPC: C10L10/02
Filed: 2013-01-16
Abstract: The invention relates to a furnace fuel and to a process for preparing the same. According to the invention, the fuel is a black fuel oil-glycerin emulsion. According to the invention, the process consists in emulsifying the black fuel oil with 3...95% glycerin in the presence of usual emulsifiers, while mechanically stirring at a rotation speed of 100...1000 rpm and a temperature of 20...100°C.