Patent SG-11201804367P-A (SG)
Title: Cycling therapy using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
Inventor: HAGNER PATRICK
IPC: A61P35/00
Filed: 2016-12-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau ... .:0) (43) International Publication Date .... ......r .,„01 8 June 2017 (08.06.2017) WI P0 I P CT ID Hit (10) WO International 2017/096024 11111111111111111111111111111111111111111111111111111111IIIIRIIIIIIIIIIIIIII Publication Number Al (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 31/517 (2006.01) A61P 35/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, PCT/US2016/064392 KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (22) International Filing Date: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 1 December 2016 (01.12.2016) OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (25) Filing Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (26) Publication Language: English ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/262,263 2 December 2015 (02.12.2015) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: CELGENE CORPORATION [US/US]; 86 TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Morris Avenue, Summit, NJ 07901 (US). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: HAGNER, Patrick; 22 Valley View Trail, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Sparta, NJ 07871 (US). GANDHI, Anita; 37 Stirling LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Road, Bernardsville, NJ 07924 (US). POURDEHNAD, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Michael; 3972 26th Street, San Francisco, CA 94131 (US). GW, KM, ML, MR, NE, SN, TD, TG). (74) Agents: BHUMRALKAR, Megha et al.; Jones Day, 250 Published: Vesey Street, New York, NY 10281-1047 — with international search report (Art 21(3)) (US). (81) Designated States (unless otherwise indicated, for every kind of national available): AE, AG, AL, AM, protection (54) Title: CYCLING THERAPY USING 3-(5-AMINO-2-METHYL-4-0X0-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE (57) : Provided herein are meth- ods of treating, preventing and/or man- Stages of Maturation aging cancer, including lymphoma, which (automatic gating) administering to a 3-(5- 105- ..•. . comprise patient . „.. 104- y1)-piperidine-2,6-dione, or an enantiomer C1) , -- C Cfp)-..- in -1.- (ii)-..- ill ji>.. 2 100- • . or a mixture of enantiomers thereof, or a HSC CMP CFO-GM Myeloblast Myelocyte Neutrophil 0- ' pharmaceutically acceptable salt, solvate, CD34 -100- hydrate, co-crystal, clathrate, or polymorph -. CD33 -100 0100 104 105 thereof in a cyclic therapy regimen. CD11b CD11b DMSO — CC-122 Continuous 0.5µM 5/7 days Block in Reversed 5/7 days myeloid maturation with 25% . 25% . 20% g -2 ree k Mil 15% -1 0 C > e , illir s otills 10% 413 laa ye 1 0% 8 Lu 2 1-1 ‘i n i SI 5% ti 15 0% ) 4 5% & 13 .4t 71. N O cr\ ‘..= N 1-1 ‘..= ei 1 2 3 4 5 6 7 8 9 10 1r Myeloid (stages) FIG. 1 1 2 3 4 5 6 7 8 9 10 Myeloid (stages) a% O