baber/WOPTO huggingface dataset:
Patent IL-133292-A0 (IL)
Title: Hybrid ion mobility and mass spectrometer
IPC: H01J49/42
Filed: 1998-06-02
Abstract: A hybrid ion mobility and time-of-flight mass spectrometer (30) includes an ion source region (32) coupled to an ion mobility spectrometer (IMS) (34) which feeds directly into an ion accelerating region of a time-of-flight mass spectrometer (TOFMS) (36). In one embodiment, the TOFMS (36) is positioned relative to the IMS (34) so that the flight tube axis (128) of the TOFMS (36) is perpendicular to the drift tube axis (72) of the IMS (34). In an alternate embodiment, the TOFMS (36) is positioned relative to the IMS (34) so that the flight tube axis (128) is non-perpendicular to the drift tube axis (72) of the IMS (34). In the alternate embodiment, a known quadruple ion trap is positioned between the IMS (34) and the TOFMS (36) to provide the capability of controlling the injection of ion packets into the TOFMS (36). The ion source (74) may be a MALDI source, an electrospray ion source, or an ion trap positioned between the IMS (34) and any known ion source. In each case, the IMS (34), TOFMS (36) and ion sources (74) are preferably controlled by a computer (38).
Patent IL-134894-A0 (IL)
Title: Tetrahydro gamma-carbolines
IPC: A61P1/00
Filed: 1998-09-01
Abstract: The present invention concerns the compounds of formula <CHEM> the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R<1> is hydrogen, optionally substituted C1-6alkyl, aryl; R<2> is each independently a halogen, hydroxy, C1-6alkyl, C1-6alkyloxy or nitro; n is 0,1,2 or 3: Alk is C1-6alkanediyl; D is an optionally substituted saturated or unsaturated nitrogen containing heterocycle; and aryl is optionally substituted phenyl; having an affinity for the serotonin receptors. It further relates to their use as a medicine, their preparation as well as compositions containing them.
Patent IL-141711-A0 (IL)
Title: Process for the production of organosilylalkyl polysulfanes
IPC: C07F7/18
Filed: 2001-02-28
Abstract: Production of organosilylalkyl polysufides (I) by reacting an organosilylalkyl halide (II) with an anhydrous ionic sulfide (III) and elemental sulfur comprises adding (III) to a suspension of elemental sulfur and (II) in a polar organic solvent. Production of organosilylalkyl polysufides of formula (I) by reacting an organosilylalkyl halide of formula (II) with an anhydrous ionic sulfide of formula (III) and elemental sulfur comprises adding (III) to a suspension of elemental sulfur and (II) in a polar organic solvent: (R 1>R 2>R 3>SiR 4>)S x (I) , R 1>R 2>R 3>SiR 4>X (II) and M 2S (III) R 1>-R 3>1-8C alkyl, 1-8C alkoxy or aryl, at least one being alkoxy; R 4>1-8C alkylene or (CH 2) n-C 6H 4-(CH 2) n; n : 1-4; x : more than 1; X : Cl, Br or I; M : an alkali metal or ammonium cation or half an alkaline earth metal or zinc cation.
Patent IL-142048-A0 (IL)
Title: Naphthalenecarboxamides as tachykinin receptor antagonists
IPC: A61P43/00
Filed: 1999-10-04
Abstract: Compounds having the following formulawherein L, M, R2, R3, R4, R5, R6, R7, X1 and X2 are as defined in the specification, pharmaceutically-acceptable salt thereof, useful for treating depression, anxiety, asthma, rheumatoid arthritis, Alzheimer's disease, cancer, schizophrenia, oedema, allergic rhinitis, inflammation, pain, gastrointestinal-hypermotility, emesis, Huntington's disease, psychoses, hypertension, migraine, bladder hypermotility, or urticaria, compositions including such compounds and processes for making such compounds.
Patent IL-145192-A0 (IL)
Title: Pyrimidine compounds
IPC: C07D239/48
Filed: 2000-03-02
Abstract: A pyrimidine derivative of formula (I) or (I'): wherein: R<x >is a substituent as defined within; Q1 is optionally substituted phenyl, and Q1 bears a substituent of formula (Ia) wherein: X, Y<1>, Y<2>, Z, n, and m are as defined within; -NQ2 is an optionally substituted heterocyclic moiety containing one hydrogen heteroatom and optionally containing a further heteroatom; or a pharmaceutically acceptable salt in vivo hydrolysable ester thereof; are useful as anti-cancer agents. Processes for their manufacture and pharmaceutical compositions containing them are described.
Patent IL-147395-A0 (IL)
Title: Bradykinin b1 receptor antagonists
IPC: A61K31/5377
Filed: 2000-07-14
Abstract: Bradykinin B<SUB>1</SUB>-receptor antagonists of formula are disclosed. The compounds are useful for treating diseases associated with inappropriate bradykinin receptor activity, such as diabetic vasculopathy, inflammation, pain, hyperalgesia, asthma, rhinitis, septic shock, atherosclerosis and multiple sclerosis. Pyrimidines, triazines, and anilines in which Q is imidazolyl or pyrrolyl are particularly preferred.
Patent IL-152211-A0 (IL)
Title: Alpha, beta-unsaturated sulfones for treating proliferative disorders
IPC: C07D333/42
Filed: 2001-04-13
Abstract: Sulfones of formula I are useful as antiproliferative agents, including, for example, anticancer agents:wherein:Q1 is selected from the group consisting of(a) a phenyl radical according to formula II whereinR1, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, amino, C1-C6 trifluoroalkoxy and trifluoromethyl;(b) an aromatic radical selected from the group consisting of 1-naphthyl, 2-naphthyl and 9-anthryl; and(c) an aromatic radical according to formula III whereinn1 is 1 or 2,Y1 and Y2 are independently selected from the group consisting of hydrogen, halogen, and nitro, andX1 is selected from the group consisting of oxygen, nitrogen, sulfur andandQ2 is selected from the group consisting of(d) a phenyl radical according to formula II, as defined above;(e) an aromatic radical selected from the group consisting of 1-naphthyl, 2-naphthyl and 9-anthryl;(f) an aromatic radical according to formula IV whereinn1 is 1 or 2,Y3 and Y4 are independently selected from the group consisting of hydrogen, halogen, and nitro, andX2, X3 and X4 are independently selected from the group consisting of carbon, oxygen, nitrogen, sulfur and provided that not all of X2, X3 and X4 may be carbon; and(g) 1-piperazinyl;provided that at least one of Q1 or Q2 is other than a phenyl radical according to formula II;or a pharmaceutically acceptable salt thereof.Sulfones of formula V are also useful as antiproliferative agents, including, for example, anticancer agents:wherein:X is sulfur or oxygen; Ya and Yb are independently selected from the group consisting of hydrogen, halogen, and nitro; and R1-R5 are defined as above;or a pharmaceutically acceptable salt thereof.
Patent IL-153746-A0 (IL)
Title: Process for preparing arylacetylaminothiazole derivatives
IPC: A61K31/427
Filed: 2001-05-02
Abstract: The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-arylacetylaminothiazole compounds of formula I:or a pharmnaceutically acceptable salt thereof, wherein:R1, R2, R4, R5, R6, R8, R9, R12 and R13 are each independently hydrogen, alkyl, aryl or heteroaryl;R3, R7, R10 and R11 are each independently hydrogen, alkyl, aryl, heteroaryl, halogen, hydroxy or alkoxy; andX is CH or N,which are novel, potent inhibitors of cyclin dependent kinases (cdks). The present invention also concerns a new process for the preparation of formylarylacetates and formylarylacetic acids.
Patent IL-157801-A0 (IL)
Title: Clothes dryer
IPC: D06F58/20
Filed: 2002-02-26
Abstract: An improved clothes dryer. The invention is a clothes dryer, which is capable of effectively drying clothes without heating the air used to dry the clothes. The dryer comprises a clothes container, a means to rotate said clothes container, and a system capable of blowing air with more than 75 times the idealized internal volume of the clothes container per minute through said clothes container. The invention can facilitate significant energy savings, is inexpensive to manufacture and has safety advantages. This is accomplished in this invention by using far more air flow through the dryer than flows through a conventional clothes dryer. The preferred embodiment has a clothes container with a high openness factor. In the preferred embodiment, the fan unit can be readily removed for servicing and cleaning. In the preferred embodiment the fan is capable of blowing approximately 200 times the volume of air as the volume of the clothes container each minute. The preferred embodiment consumes only approximately 500 watts.
Patent IL-165975-A0 (IL)
Title: Minimally compliant volume efficient piston for osmotic drug delivery systems
IPC: A61M31/00
Filed: 2004-12-23
Abstract: An osmotic pump having a minimally compliant, volume-efficient piston positioned within a capsule is provided. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length-to-total-diameter ratio of about 1.1:1 and a core-diameter-to-total-diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.
Patent IL-177881-A0 (IL)
Title: Heat exchanger having a vacuum tube
IPC: F24J2/48
Filed: 2006-09-04
Abstract: A heat exchanger comprises a vacuum tube with an outer wall. An inner tube can be filled with a heat-conducting fluid. The outer wall of the inner tube is situated concentric to a wall of the vacuum tube. At least one heat-conducting film is provided that joins said wall of the vacuum tube to the fluid-conducting tube system. A means which collects and concentrates solar energy is provided on the wall on the side of the vacuum tube facing away from the heat-conducting element. In addition, each heat-conducting element, while being pretensioned, presses against the wall of the vacuum tube and against the fluid-conducting tube system.
Patent IL-210359-A0 (IL)
Title: Site specific incorporation of keto amino acids into proteins
IPC: C12N15/67
Filed: 2010-12-29
Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.
Patent RO-130058-A0 (RO)
Title: Device for screwing the cap on a glass or pet container
Inventor: COCIRTA THOMAS
IPC: B67B3/20
Filed: 2014-09-29
Abstract: The invention relates to a device for screwing the cap on a glass or PET container with high speed, intended to be mounted on filling equipments in the food, chemical, pharmaceutical or cosmetic fields. According to the invention, the device consists of a gravity feeder (), the cap () being positioned and centered above the container () by a mechanism with mobile tweezers (), the cap () being clamped and driven by a screwing crown () provided with some inner grooves with shapes complementary to the shape of the grooves on the outer surface of the cap (), the cap () being screwed by means of a piece () mounted at the lower extremity of a grooved shaft () which simultaneously performs two motions : a forward parallel motion and a rotary motion, where, due to said forward parallel motion, the screwing crown () mounted at the end of the shaft () drives the cap () and applies it on the neck of the container (), and, due to rotary motion, the cap () is screwed on the neck of the container (); at the end of the screwing, the pneumatic drive (), by means of the grooved shaft () and of the screwing piece (), retracts the screwing crown () from the working area, the tweezers () being brought to the initial position by means of a spring () mounted on the outer side of the tweezer system.
Patent AP-2002002634-A0 (AP)
Title: Malonamic Acids And Derivatives Thereof As Thyroid Receptor Ligands.
Inventor: ASPNES GARY ERIK
IPC: A61P9/10
Filed: 2001-03-07
Abstract: The present invention relates to novel thyroid receptor ligands and, more particulary, relates to malonamic acids and derivatives thereof formula (1), which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depresssion and osteoporosis. The present invention also provide methods, pharmaceutical compositions and kits for treating such diseases and disorders.
Patent AP-2004003123-A0 (AP)
Title: Thiazole and oxazole derivatives that modulate PPAR activity
Inventor: CHENG XUE-MIN
IPC: C07D277/26
Filed: 2003-03-03
Abstract: This invention discloses compounds that alter PI'AR aclivily. The invention also discloses pharmaceulically acccpl-able sails of compounds, pharmaceulically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or prcveniinj! hyperlipiclemia and hypcrcholeslercniut in a mammal. The present invention also discloses method lor making the disclosed compounds.
Patent LU-87037-A1 (LU)
Inventor: PHILIPPE MICHEL
IPC: A61K8/34
Filed: 1987-11-04
Abstract: Polyaromatic esters of macrolidic and lincosamidic antibiotics are employed in the treatment of acne.
Patent MA-20150206-A1 (MA)
Title: Accumulateur mécanique d'énergie
Inventor: MAFHOUM ABDERRAZZAK
IPC: F03G3/00
Filed: 2013-11-19
Abstract: L’invention concerne un accumulateur de l’énergie mécanique pour emmagasiner l’énergie pour des une longue durée, surtout les énergies ne pouvant pas être emmagasinée come les énergies solaires et éoliennes. L’accumulateur est composé de boules ayant une masse volumique importante (5,6,11,16 figure 4), qui se déplacent de la surface inférieure (2, figure 4) via un élévateur (4, figure 4) vers une surface supérieure (1, figure 4). L’élévateur consomme l’énergie à convertir en la convertissant à un mouvement de rotation faisant tourner l’un des pignons ou en le convertissant à une énergie électrique alimentant un moteur relié à un pignon, ainsi l’énergie sera emmagasinée. Au besoin de cette énergie, les boules sont dirigées vers le bas (3, figure 4) ce qui entraine la rotation des pignons, ce mouvement est exploité directement ou indirectement.Bref, on emmagasine de l’énergie en soulevant les boules à la surface supérieure, et au besoin de cette énergie les boules sont dirigés vers la surface inférieure.
Patent MA-39051-A1 (MA)
Title: Procédé de désodorisation d'une boue et dispositif mettant en oeuvre un tel procédé
Inventor: CAPEAU PATRICE
IPC: C02F11/148
Filed: 2016-05-20
Abstract: Il s'agit d'un procédé et d'un dispositif de traitement en continu d'un flux de boue liquide organique. Après ajout s'il y a lieu de matière minérale granuleuse dans le flux, on injecte la boue (5) à un débit q dans une colonne d'air en surpression par rapport à la pression atmosphérique, ladite colonne d'air circulant à un débit q > 5q dans une enceinte (2, 4) s'étendant sur une longueur déterminée l le long d'un axe (3) longitudinal, pour créer un lit fluidisé, dans lequel la boue est aérolisée, entre une tuyauterie d'alimentation de l'air en amont de l'injection de boue et une canalisation ou un réservoir de sortie en aval du lit fluidisé obtenu, ladite canalisation ou ledit réservoir étant à la pression atmosphérique ou sensiblement à la pression atmosphérique, et on introduit un floculant (21) en continu en aval de l'enceinte dans ledit lit fluidisé pour regrouper la matière organique avant séparation de la partie solide ainsi obtenue de la partie liquide, la partie solide obtenue étant ainsi désodorisée.
Patent UY-29191-A1 (UY)
Title: Formulaciones liposómicas de compuestos de ácido borónico
Inventor: ZALIPSKY SAMUEL
IPC: A61K9/00
Filed: 2005-11-04
Abstract: Se describe una composición liposómica conformada por liposomas que contienen un compuesto de ácido borónico peptídico, inhibidor del proteasoma, atrapado en los liposomas. El compuesto de ácido borónico peptídico se encuentra atrapado en los liposomas en la forma de un éster de boronato, luego de la interacción con un poliol atrapado en el liposoma. En una modalidad, los liposomas presentan un recubrimiento exterior de cadenas de polímeros hidrofílicos y se utilizan para tratar un tumor sólido en un sujeto.
Patent UY-29207-A1 (UY)
Title: Sal l-tartrato de n-1-adamantil-2-(3-((2r)-2-(((2r)-2-hidroxi-2-(4-hidroxi-3-hidroximetil)fenil)etil)amino)propil)fenil)acetamida
Inventor: JAMES KIM
IPC: C07C237/20
Filed: 2005-11-11
Abstract: Esta invención se refiere a la sal L-tartrato de N-1-adamantil-2-(3-((2R)-2-(((2R)-2-hidroxi-3-(hidroximetil)fenil)etil)amino)propil)fenil)acetamida y a su uso como medicamento
Patent CS-497085-A1 (CS)
Title: Zarizeni pro urychlene prizpusobeni elektrod pri elektrojiskrovem opracovani
Inventor: HEERDT JOCHEN DIPL ING
IPC: B23H9/04
Filed: 1985-07-03
Abstract: In a spark erosion process for working roller-shaped component, the electrodes are grouped with an even number of segment (1-6) to a group and stretch parallel to the axis of the component. The electrode holder is inclined to the component surface such that at least 50% of the work surface of the electrodes is at the required distance for spark erosion. This is achieved by connecting the electrodes in pairs to voltage sources with the outer electrodes (1,6) followed by the next pair etc.
Patent ES-179912-A1 (ES)
Title: MEJORAS EN AMPLIFICADORES DE LiNEA PARA SISTEMAS DE TRES CANALES DE ONDA PORTADORA PARA LiNEAS ALáMBRICAS
IPC: H03G3/08
Filed: 1947-09-27
Abstract: Mejoras en amplificadores termoiónicos de regeneración negativa de pasos múltiples que comprenden un circuito regenerativo total que incluye todos los pasos y un circuito regenerativo local que incluye cualquier número de pasos con exclusión del primero e incluyendo el último proveyéndose medios para aumentar simultáneamente la ganancia en el circuito positivo que comprende todos los pasos y reducir la pérdida en el circuito regenerativo total de tal forma que la propagación alrededor del bucle regenerativo total permanece esencialmente constante para todos los ajustes de dichos medios.
Patent ES-181069-A1 (ES)
Title: UN PROCEDIMIENTO PARA LA FABRICACIoNDE ABONO FOSFONiTICO
Filed: 1947-12-22
Abstract: Un procedimiento de fabricación de abono fosfocítrico que comprende el ataque del fosfato de cal natural por ácido nítrico mediante concentrado y utilizado sólo o en mezcla con el ácido sulfúrico, el ácido fosfórico o ambos, y después de separar las sales de calcio formadas, o sin separarla la neutralización por el amoniaco del producto resultante del ataque; procedimiento que se caracteriza porque la neutralización se realiza según un círculo contínuo en varias cubas recorridas en serie por la pasta siendo la velocidad de introducción de amoniaco para cada cuba, fijada de una vez para siempre en un valor todo lo próximo posible a la velocidad de absorción la cual tambien es constante para la cuba de que se trata.
Patent ES-181639-A1 (ES)
Title: Un quemador de aceite pesado
Filed: 1948-01-12
Abstract: Un quemador de aceite pesado, que tiene por lo menos un cuerpo prismático provisto de una ánima axial, teniendo cada cuerpo un inyector de puntero con resorte de tracción, siendo el aceite pesado y el aire a presión conducidos por separado al cuerpo del quemador por tuberías de unión; quemador caracterizado porque, contiene, solos o en combinación: a) Un cuerpo prismático que constituye el quemador propiamente dicho y que recibe el aceite pesado, y cuyo extremo está provisto de una tobera que hace las veces de pulverizador; estando este cuerpo sujeto a un segundo cuerpo prismático que recibe el aire a presión comunicándose los dos cuerpos por su parte anterior y estando provistos de sendos inyectores de puntero que permiten regular separadamente el suministro del aceite y del aire a presión. b) Una leva dispuesta dentro de cada cuerpo prismático y que actúa automáticamente sobre la cabeza del puntero bajo la acción de un regulador mandado desde el termostato del aparato de calentamiento para suministrar el aire a presión y el aceite pesado necesarios para la formación de la mezcla gaseosa y para variar el régimen de marcha del aparato de calentamiento por la regulación de su suministro. c) Una leva colocada fuera de cada cuerpo prismático cuya cabeza del puntero el extremo posterior del cuerpo, estando montadas las dos levas en un árbol común que oscila el termostato por medio de una palanca común a las dos levas, habiendo una chapa de doble tope intercaladas en este dispositivo para limitar en cada sentido la carrera de oscilación de la palanca.
Patent ES-182396-A1 (ES)
Title: Mejoras en sistemas conmutadores.
IPC: H04Q11/04
Filed: 1948-02-16
Abstract: Mejoras en sistemas conmutadores caracterizada porque en un sistema de comunicación, se preven una multiplicidad de líneas, una multiplicidad de enlaces, los medios para seleccionar un enlace por la iniciación de una llamada en una línea, una señal repetidora, los medios para controlar sobre la línea que llama y el repetidor para seleccionar una línea llamada, los medios para transmitir a través dichas señales repetidoras de/y desde las líneas que llaman y llamadas sobre los medios de distribución, los medios de incluir las señales desde la línea que llama para controlar la selección de la línea llamada, los medios que incluyen un conmutador de posición múltiple electrónica variable y operable de acuerdo con la operación de selección últimamente mencionada.
Patent ES-183082-A1 (ES)
Title: MáQUINA LIMADORA PARA METALES EN GENERAL
Filed: 1948-05-30
Abstract: Máquina limadora para metales en general, caracterizada porque se compone de un motor que transmite su movimiento a un juego de velocidades, una rueda excéntrica y una biela, la cual comunica un movimiento de traslación a una cabeza de carnero a cuyo extremo está acoplada la herramienta cortante.
Patent ES-189256-A1 (ES)
Title: UN PROCEDIMIENTO PARA LA OBTENCIoN DE COMPOSICIONES PARA IGUALAR SUPERFICIES IMPERFECTAS DE ESTRUCTURAS METáLICAS
IPC: C09D167/06
Filed: 1949-07-29
Abstract: Procedimiento para la obtención de composiciones para igualar superficies imperfectas de estructuras metálicas caracterizado porque dichas composiciones comprenden partes en peso aproximadamente iguales de material orgánico e inorgánico; el material orgánico contiene estireno prácticamente no-polimerizado y una mezcla de aluminio de escamas y granular.
Patent ES-193618-A1 (ES)
Title: DISPOSICIoN DEL MECANISMO DE TRANSMISIoN EN VEHiCULOS AUTOMoVILES, ESPECIALMENTE OMNIBUSES
Filed: 1950-06-24
Abstract: Disposición del mecanismo de transmisión de vehículos automóviles especialmente en omnibuses en los que uno o varios ejes del vehículo se impulsan por dos máquinas motrices a través de un mecanismo común de cambio de velocidades caracterizada porque en cada lado del vehículo está dispuesta una máquina motríz en dirección longitudinal cerca detrás de la rueda delantera del correspondiente lado del vehículo.
Patent ES-198151-A1 (ES)
Title: Un procedimiento para recuperar y purificar azufre
Filed: 1951-06-02
Abstract: Un procedimiento para recuperar y purificar azufre, caracterizado porque la disolución en caliente se hace seguir por un enfriamiento brusco con lo que el azufre cristaliza a la temperatura de enfriamiento a partir de la solución sobresaturada, quedando el alquitrán en solución y obteniéndose así una separación selectiva del azufre y el alquitrán, realizándose luego la separación del azufre desde la solución que contiene al alquitrán por filtración compresión y/o centrifugación.