baber/WOPTO huggingface dataset:
Patent NZ-570890-A (NZ)
Title: Apparatus for toasting a wine barrel
Inventor: MANNO PAL
IPC: B27H5/08
Filed: 2008-08-29
Abstract: An apparatus for toasting a barrel comprises a platform having an opening therein. The opening is adapted to receive a heat source therethrough and the platform is rotatably disposed about the heat source and comprises a guide disposed on a surface of the platform which is adapted to position a barrel on the platform about the opening, coaxial with the heat source; and a motor operatively connected to the platform for rotating the platform about the heat source at a substantially constant speed. The apparatus can further comprises a central processing unit; a temperature sensor for sensing the temperature at a predetermined position an interior of a barrel disposed on the platform and providing a temperature output; a clock outputting a clock signal corresponding to an interval during which a barrel is exposed to the heat; a database storing toasting recipes, the toasting recipes being a function of time and temperature and an alarm. The central processing unit receives a temperature input from the sensor and the clock signal from the clock, determines a current interval and utilizes the recipe stored in the database to provide an output to the alarm if the sensed temperature during the interval does not substantially correspond to the temperature corresponding to the recipe stored in the database.
Patent NZ-578235-A (NZ)
Title: Modulators of sclerostin binding partners for treating bone-related disorders
Inventor: LU CHRIS XIANGYANG
IPC: A61P19/10
Filed: 2008-01-30
Abstract: Provided is the use of a composition comprising a modulator of a sclerostin-binding partner in the manufacture of a medicament for treatment of a pathological disorder, wherein the sclerostin-binding-partner is LRP4 and wherein the modulator is an antibody or a functional protein comprising an antigen-binding portion of said antibody specifically binding to LRP4, and wherein said antibody or functional protein comprising an antigen binding portion of said antibody inhibits binding of sclerostin to LRP4, and wherein said pathological disorder is an aberrant bone mineral density disorder selected from osteoporosis or sclerosteosis.
Patent NZ-582794-A (NZ)
Title: Modified lecithin-cholesterol acyltransferase enzymes
Inventor: SCHWARZ MARGRIT
IPC: A61K38/45
Filed: 2008-07-25
Abstract: Disclosed is a modified lecithin-cholesterol acyltransferase (LCAT) wherein, (a) the modified LCAT protein comprises a modification to the mature LCAT amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2, (b) the modification consists of a substitution at position C31, and (c) the modified LCAT protein has increased LCAT enzymatic activity compared to the LCAT protein of SEQ ID NO: 1 or 2 as measured in a cholesterol esterification rate (CER) plasma LCAT activity assay. Further disclosed is a modified lecithin-cholesterol acyltransferase (LCAT) , wherein (a) the modified LCAT protein comprises a modification to the mature LCAT amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2, and (b) the modification consists of a substitution at position C31, and an additional substitution at position F1, L3, L4, N5, L7, N384 or E416.
Patent NZ-588459-A (NZ)
Title: Smoking article with transparent section in the material which connects filter to tobacco rod
Inventor: CECCHETTO ANDREA
IPC: A24C5/56
Filed: 2009-06-02
Abstract: 588459 Disclosed is a smoking article (1) comprising a tobacco rod (2), a filter (4) located at the mouth end of the smoking article (1), at least one tipping material (6), to attach the filter (4) to the tobacco rod (2). The at least one tipping material (6) comprises at least one transparent section (7) so that a portion of the filter is visible to the user. The smoking article (1) further comprises a ventilation zone (8) upstream of the at least one transparent section (7).
Patent NZ-588583-A (NZ)
Title: Novel lipid formulations for nucleic acid delivery
Inventor: MACLACHLAN IAN
IPC: A61P1/16
Filed: 2009-04-15
Abstract: Disclosed is a nucleic acid-lipid particle with improved serum stability comprising: A.) A nucleic acid, particularly a small interfering RNA (siRNA); B.) A cationic lipid comprising from 50 mol percent to 65 mol percent of the toal lipid present in the particle; C.) A non-cationic lipid comprising a mixture of a phospholipid and cholesterol or a derivative thereof, wherein the phospholipid comprises from 3 mol percent to 15 mol precent of the total lipid present in the particle and the cholesterol or derivative thereof comprises from 30 mol percent to 40 mol percent of the total lipid present in the particle; and D.) A conjugated lipid that inhibits aggregation of particles comprising from 0.5 mol percent to 2 mol percent of the total lipid present in the particle. Further disclosed is a pharmaceutical composition comprising said nucleic acid-lipid particle and a pharmaceutically acceptable carrier, and the use of said nucleic acid -lipid particle in the manufacture of a medicament for the in vivo delivery of a nucleic acid or for treating a disease or disorder such as viral infection, a liver disease, and cancer.
Patent NZ-597764-A (NZ)
Title: Agricultural methods and compositions comprising an acid stable silane surfactant
Inventor: ELLIOTT GARRY
IPC: A01N25/30
Filed: 2010-01-20
Abstract: 597764 Disclosed is a method of reducing the amount of water required to apply an acidic active agent (such as citric acid, lactic acid, and buffered phosphorous acid or combinations thereof) to a crop, the method including the steps of: mixing the acidic active agent with an acid stable surfactant and water, wherein the acid stable surfactant is a composition including a silicon containing compound having the formula: (R1)(R2)(R3)Si-R4-Si(R5)(R6)(R7), wherein R1, R2, R3, R5 and R6 are each independently selected from the group consisting of 1 to 6 monovalent hydrocarbon radicals, aryl, and a hydrocarbon group of 7 to 10 carbons containing an aryl group; R4 is a hydrocarbon group of 1 to 3 carbons; R7 is an alkyleneoxide group of the general formula: R8(C2H4O)d(C3H6O)e(C4H8O)fR9, where R8 is a divalent linear or branched hydrocarbon radical having the structure: -CH2-CH(R10)(R11)gO-, where R10 is H or methyl; R11 is a divalent alkyl radical of 1 to 6 carbons where the subscript g is 0 or 1; R9 is selected from the group consisting of H, monovalent hydrocarbon radicals of 1 to 6 carbon atoms and acetyl, subject to the limitation that the subscripts d, e and f are zero or positive and satisfy the following relationships: 2 ? d + e + f ? 20 with d ? 2; and applying the mixture, including acid stable surfactant, acidic active agent and water to the crop using less than 2800 litres of water per hectare of the crop. Also disclosed is a composition for use in the above method including an acidic active agent of pH< 5 prior to inclusion in the composition, an acid stable surfactant and water, wherein the volume ratio of acidic active agent to water is between 1 :200 and 6:200, wherein the acid stable surfactant is a composition including a silicon containing compound having the formula: (R1)(R2)(R3)Si-R4-Si(R5)(R6)(R7) as defined above.
Patent NZ-599553-A (NZ)
Title: Ethynyl derivatives
Inventor: GREEN LUKE
IPC: A61K31/4162
Filed: 2010-12-14
Abstract: The present disclosure relates to ethynyl derivatives of formula (I) wherein X is N or C-R1; Y is N or C-R2; Z is CH or N; R4 is a 6-membered aromatic substituent containing 0, 1 or 2 nitrogen atoms, optionally substituted by 1 to 3 groups, selected from halogen, lower alkyl, lower alkoxy or NRR’; R1 is hydrogen, lower alkyl, lower alkoxy, hydroxy, lower hydroxyalkyl, lower cycloalkyl or is heterocycloalkyl optionally substituted with hydroxy or alkoxy; R2 is hydrogen, CN, lower alkyl or heterocycloalkyl; R and R’ are independently from each other hydrogen or lower alkyl; or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has now surprisingly been found that the compounds of general formula (I) are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) and they are therefore useful for the treatment of diseases related to this receptor. Compounds of the disclosure include: 6-Phenylethynyl-[1,2,3]triazolo[1,5-a]pyridine, 2-tert-Butyl-6-phenylethynyl-pyrazolo[1,5-a]pyridine, 6-Phenylethynyl-2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyrimidine, 2-Methyl-2-(6-phenylethynyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-propan-1-ol, 2-Cyclobutyl-6-phenylethynyl-pyrazolo[1,5-a]pyrimidine, 2-Isopropyl-6-phenylethynyl-pyrazolo[1,5-a]pyrimidine, 6-(4-Chloro-phenylethynyl)-2-methyl-pyrazolo[1,5-a]pyrimidine and 6-(2-Fluoro-phenylethynyl)-2-methyl-pyrazolo[1,5-a]pyrimidine
Patent NZ-600222-A (NZ)
Title: Turbine
Inventor: TAY BOB
IPC: F03B17/06
Filed: 2010-08-09
Abstract: A wind turbine for capturing energy from a fluid flow comprises a rotor having a rotational axis and a plurality of rotor blades (104) arranged for rotation about the rotational axis. The rotor blades extend longitudinally in a direction substantially parallel to the rotational axis. A shield member V3 is arranged to shield some of the rotor blades from an oncoming wind where incidence of the wind on those rotor blades would act against rotation of the rotor in the direction of rotation. The rotor blades (104) are distributed about the circumference of the rotor and are spaced from the rotational axis, defining a substantially cylindrical space within the rotor through which the wind passes. The shield member V3 is defined by a radially inward surface and a radially outward surface. The radially inward surface follows substantially a portion of the circumference of the rotor. The radially outward surface of the shield member V3 comprises a first portion which meets the radially inward surface. In the region of the interface with the radially inward surface, the first portion extends in a first direction n that makes an angle of at least 0 degrees and up to 90 degrees in the contra-rotational direction with the radial direction of the rotor. The radially outward surface of the shield member V3 has a second portion which meets the first portion. The angle between the first direction and a second direction which follows at least a portion of the surface of the second portion is more than 0 degrees and less than 100 degrees in the contra-rotational direction. The radially outward surface of the shield member has a third portion which meets the second portion. The third portion extends in a third direction that makes an angle of more than 0 degrees in the rotational direction with the second direction.
Patent NZ-600889-A (NZ)
Title: Agents for treating disease
Inventor: CZELOTH NIKLAS
IPC: G01N33/50
Filed: 2010-11-30
Abstract: Disclosed is a method for screening for a molecule capable of binding to CD4 comprising: (a) providing one or more candidate molecules; (b) determining whether the one or more candidate molecules is capable of binding to one or more of the following regions of human CD4: amino acids 148 to 154, amino acids 164 to 168 and amino acids 185 to 192; and (c) selecting a molecule determined in step (b) to be capable of binding to CD4. Also disclosed is an antibody or antibody fragment capable of activating CD4+CD25+ regulatory T cells comprising a light chain variable domain comprising a CDR1, a CDR2 and a CDR3 and a heavy chain variable domain comprising a CDR1, a CDR2 and a CDR3, wherein the light chain variable domain and/or the heavy chain variable domain are variants of the variable domains of the BT061 antibody with at least one amino acid substitution in the sequences of the CDRs provided that: (i) the light chain CDR1 comprises: Ser32; Gly33; and Tyr 34; (ii) the light chain CDR2 comprises: Leu54; and Ile57; (iii) the heavy chain CDR1 comprises Asp31, Glu31, Thr31, Cys31, Pro31, Met31 or Tyr31; and (iv) the heavy chain CDR3 comprises Tyr103, Phe103 or His103; Arg104; Tyr105; Asp106; and Trp110, Phe110, His 110 or Tyr110, wherein the at least one amino acid substitution is an isosteric variation, wherein the light chain V domain has at least 80% sequence identity to the BT061 light chain, and the heavy chain variable domain has at least 80% sequence identity to the BT061 heavy chain.
Patent NZ-600999-A (NZ)
Title: Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
Inventor: PETERSSON KARSTEN
IPC: A61K9/06
Filed: 2010-12-22
Abstract: Provided is a substantially anhydrous pharmaceutical composition of vitamin D derivative for cutaneous application comprising 1-20% by weight of an isotropic solvent mixture of (a) a hydrophilic non-ionic surfactant which is a polyethylene glycol ester of a vegetable oil containing at least 20 mole of ethylene oxide groups/mole of glyceride; (b) a lipophilic non-ionic co-surfactant which is selected from the group consisting of monoglyceride esters of C6-22 fatty acids, diglyceride esters of C6-22 fatty acids, mono- and diglyceride esters of C6-22 fatty acids, propylene glycol esters of C6-22 fatty acids, dialkylene glycol monoalkyl ethers, or polyethylene glycol esters of a triglyceride/vegetable oil containing 4-8 mole of ethylene oxide groups/mole of glyceride; (c) a C6-22 acylglyceride which is a non-amphiphilic C6-22 acylglyceride selected from the group consisting of highly purified vegetable oils such as medium chain triglycerides, long chain triglycerides or castor oil; said isotropic solvent mixture being capable of forming a microemulsion in the presence of an excess of water; the composition further comprising a calcipotriol, calcitriol, tacalcitol, maxacalcitol, paricalcitol and alfacalcidol dissolved or solubilized in said isotropic solvent mixture, and a pharmaceutically acceptable, substantially anhydrous lipid carrier which is a paraffin selected from hydrocarbons with chain lengths from C5 to C60. The composition may be used to treat a dermal disease or condition selected from the group consisting of psoriasis, sebopsoriasis, pustulosis palmoplantaris, dermatitis, ichtyosis, rosacea or acne.
Patent NZ-601051-A (NZ)
Title: Method of detecting a flow, detection device, automatic milking device and computer program
Inventor: DE GROOT PIETER GERLOF
IPC: A01J5/01
Filed: 2011-03-03
Abstract: 601051 Disclosed is a method of detecting a flow of milk (8) in a milk line (2). The milk line (2) is connected to a teat cup (3) having a pulsator space (6) and which has an aeration opening (5) such that the milk (8) defines a filling level in a measuring section (7) of the milk line (2). A milking vacuum is applied in the milk line (2), and a pulsating vacuum is applied in the pulsator space (6) of the teat cup (3). The filling level of the milk (8) is measured in the measuring section (7) at least during a first period of time (Δt). A variation is determined of the filling level measured at least during the first period of time (Δt) in the form of an indicator number which is then compared with a predetermined threshold value. The threshold value is indicative of the presence or absence of a flow of milk (8) in the milk line (2).
Patent NZ-613433-A (NZ)
Title: Modified plant defensins useful as anti-pathogenic agents
Inventor: VAN DER WEERDEN NICOLE
IPC: C12N15/62
Filed: 2012-02-07
Abstract: Disclosed is an isolated artificially modified solanaceous Class II defensin polypeptide with a loop region (Loop 1B) between a first Beta-strand and an Alpha-helix at its N-terminal end portion and having anti-fungal activity, and wherein said Loop 1B is replaced by an exogenous Loop 1B amino acid sequence, said polypeptide having at least 70% similarity to SEQ ID NO:52 after optimal alignment; wherein SEQ ID NO: 52 is as disclosed in the specification.
Patent NZ-619104-A (NZ)
Title: Improvements in and relating to splitting apparatus
Inventor: VAUGHAN JOHN HUTCHINSON
IPC: B27L7/06
Filed: 2012-12-21
Abstract: An apparatus (1) for mechanically splitting materials and a method of manufacturing and using the apparatus is disclosed. Material to be cut, such as wood (2), is placed over the cutting blade (3) and struck with a mallet (15) or similar. A safety means (11) prevents severed pieces of the material injuring the user and may also be contained by a shield or container (13). The safety means encircles the blade.
Patent NZ-620447-A (NZ)
Title: Quinolone compound
Inventor: ABUDUSAIMI MAMUTI
IPC: C07D471/04
Filed: 2012-08-30
Abstract: The present disclosure provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present disclosure has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile- associated diarrhea.
Patent NZ-625086-A (NZ)
Title: Povidone iodine, a novel alternative preservative for ophthalmic compositions
Inventor: LIANG BO
IPC: A61K31/56
Filed: 2009-06-10
Abstract: Disclosed herein is an stable ophthalmic composition suitable for topical administration to the eye, comprising a mixture of: (a) povidone-iodine (PVP-I) at a concentration between 0.01% and 10%, and (b) a steroid, wherein the steroid is dexamethasone, wherein the pH of the composition is in the range of 3 to 4. Said stable ophthalmic composition may further comprises an antimicrobial preservative selected from the group consisting of benzalkonium chloride, thimerosal, chlorobutanol, methyl paraben, propyl paraben, phenylethyl alcohol, EDTA, sorbic acid, polyquarternium 1, and any combination thereof; a viscosity increasing agent selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, methyl cellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, hydroxypropylcellulose, and any combination thereof; and a co-solvent/surfactant is selected from the group consisting of polysorbate 20, polysorbate 60, polysorbate 80, poloxamer 188, poloxamer 234, poloxamer 333, cyclodextrin, tyloxapol and a combination thereof.
Patent NZ-627542-A (NZ)
Title: Improved solid herbicide compositions with built-in adjuvant
Inventor: DAVE HITESHKUMAR
IPC: A01P13/00
Filed: 2013-01-24
Abstract: The present disclosure relates to solid herbicidal compositions, such as granules and powders, containing built-in adjuvant, which have improved stability and exhibit acceptable herbicidal efficacy when used to control weeds in flooded rice paddies fields, or cereal crop fields. Particularly disclosed is a solid herbicidal composition comprising: (a) at least one herbicide selected from the class of ACCase and ALS enzyme inhibitors and compounds of the Formula shown herein and the variables are as defined in the specification, wherein the herbicide(s) is present in the composition in an amount of from about 1 gram per kilogram (g/kg) to about 200 g/kg relative to the total weight of the composition; (b) one or more built-in adjuvant, wherein the built-in adjuvant(s) is present in the composition in an amount of from about 50 g/kg to about 750 g/kg relative to the total weight of the composition, wherein the built-in adjuvant is a non-ionic surfactant or water-immiscible liquid; and (c) one or more solid, water soluble polymer or oligomer, wherein the solid, water soluble polymer(s) or oligomer(s) is present in the composition in an amount of from about 200 g/kg to about 700 g/kg relative to the total weight of the composition; wherein the composition does not comprise solid carbohydrate, wherein when the one or more solid, water soluble polymers or oligomers comprises polyvinyl alcohol, the polyvinyl alcohol is present in the composition in an amount less than 7% by weight relative to the total weight of composition.
Patent NZ-702366-A (NZ)
Title: Multi-layered light-weight wood products consisting of materials containing lignocellulose with a core and two covering layers, with treated cellulose material, treated natural fibres, synthetic fibres or mixtures thereof in said core
Inventor: Weinkötz Stephan
IPC: C08L97/02
Filed: 2013-06-25
Abstract: The invention relates to materials containing lignocellulose that have a core and two covering layers, containing and preferably consisting of, in said core: A) 30 to 98 wt.% of lignocellulose particles, B) 0 to 25 wt.% of expanded plastic particles with a bulk density in the range of 10 to 150 kg/m3, C) 1 to 50 wt.% of one or more binders selected from the group consisting of aminoplast resin, phenol formaldehyde resin, and organic isocyanate with at least two isocyanate groups, and D) 0 to 10 wt.% of additives, and, in said covering layers: E) 70 to 99 wt.% of lignocellulose-containing particles, fibres, or mixtures thereof, F) 1 to 30 wt.% of one or more binders selected from the group consisting of aminoplast resin, phenol formaldehyde resin and organic isocyanate with at least two isocyanate groups, and G) 0 to 10 wt.% of additives; with 2 to 30% of the lignocellulose particles A) being replaced with treated cellulose materials, treated natural fibres, synthetic fibres or mixtures thereof. The invention also relates to the production and use of same.
Patent NZ-702684-A (NZ)
Title: Hexadepsipeptide analogues as anticancer compounds
Inventor: SHARMA RAJIV
IPC: C07K11/02
Filed: 2013-05-06
Abstract: This invention relates to an isolated compound of Formula (1) or derivatives or pharmaceutically acceptable salts thereof. The invention also includes all isomeric and tautomeric forms of the compound of Formula (1) or the derivatives thereof. The present invention further relates to processes for the production of the compound of Formula (1) by fermentation of the fungal strain of Actinomycetes (PM0895172/MTCC 684), pharmaceutical compositions comprising the compound of Formula (1) as the active ingredient; and use of the said compounds or composition containing them in the treatment of cancer.
Patent NZ-709541-A (NZ)
Title: Compounds and methods for purification of serine proteases
Inventor: PANDEY ANJALI
IPC: B01D15/38
Filed: 2013-12-27
Abstract: Disclosed herein are affinity solid supports, compositions, methods and kits for purifying a protease and serine proteases purified with the compounds, compositions and methods. In some embodiments, the affinity solid support for purifying a protease is of formula II as shown. Also disclosed are intermediate compounds for preparing the affinity solid supports.
Patent NZ-714014-A (NZ)
Title: Therapeutic effect prediction method for colorectal cancer patient in whom expression of tk1 protein has increased
Inventor: SAKAMOTO KAZUKI
IPC: G01N33/574
Filed: 2014-05-16
Abstract: The present invention provides a method for predicting the therapeutic effect of chemotherapy using an anti-tumor agent that contains trifluridine and tipiracil hydrochloride at a molar ratio of 1:0.5 on a colorectal cancer patient, said method comprising the steps (1)-(3) that are indicated below. As a means of solving the problem addressed by the present invention, a method comprising the following steps is provided: a step (1) in which the expression of the TK1 protein in the cytoplasm of a tumor cell that is included in a biological sample taken from the patient is detected using immunohistochemistry; a step (2) in which tumor cells are classified as positive cells and negative cells from the detection result obtained at step (1) and the share of positive cells among the tumor cells is calculated; and a step (3) in which, when the share is 30% or higher, it is predicted from the calculation result obtained at step (2) that there is a high possibility that chemotherapy using an anti-tumor agent that contains trifluridine and tipiracil hydrochloride at a molar ratio of 1:0.5 will have a sufficient therapeutic effect on the patient.