Patent SG-11201811227Q-A (SG)
Title: Method for facilitating maturation of the mammalian immune system
Inventor: KYLE DAVID
IPC: A61K35/741
Filed: 2017-06-30
Abstract: 0 Q o ,0 Q 0 10 20 30 40 Sampling Day FIG. 1 60 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 January 2018 (04.01.2018) WIP0 I PCT onion OH oI0IIIIIIII1101VIII 111110 Hs (10) International Publication Number WO 2018/006080 Al (51) International Patent Classification: A23L 33/135 (2016.01) A61K 35/741 (2015.01) A61K 31/702 (2006.01) A61K 35/745 (2015.01) (21) International Application Number: PCT/US2017/040530 (22) International Filing Date: 30 June 2017 (30.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/357,820 01 July 2016 (01.07.2016) US 62/397,788 21 September 2016 (21.09.2016) US (71) Applicant: EVOLVE BIOSYSTEMS INC. [US/US]; 2121 2nd Street, Suite B107, Davis, California 95618 (US). (72) Inventors: KYLE, David; P.O. Box 119, Gualala, Califor- nia 95445 (US). FRESE, Steven; 9163 Olmos Lane, Davis, California 95616 (US). FREEMAN-SHARKEY, Samara; 5248 Hamel Street, Davis, California 95618 (US). HEN- RICK, Bethany; 521 7th Street, Cottage 10, Davis, Cali- fornia 95616 (US). (74) Agent: POSORSKE, Laurence H. et al.; Hunton & Williams LLP, Intellectual Property Department, 2200 Pennsylvania Ave., NW, Washington, District of Columbia 20037 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (54) Title: METHOD FOR FACILITATING MATURATION OF THE MAMMALIAN IMMUNE SYSTEM (57) : The inventions described herein relate generally to the use of compositions to increase output of acetate and lactate while reducing pH and the levels of pathogenic bacteria and inflammation in the gut of a nursing infant mammal including humans. *t These compositions generally comprise one or more bacterial strains selected for their growth on mammalian milk oligosaccharides, a 1-1 © source of mammalian milk oligosaccharides, and, optionally, nutritive components required for the growth of that infant mammal. O [Continued on next page] WO 2018/006080 Al MIDEDIMOMMIDIRER 10101 1101 INIIMMOIHMEMOIS UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(1)) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))