Patent SG-11201804178Y-A (SG)
Title: Pd1 and/or lag3 binders
Inventor: BOWMAN EDWARD
IPC: C07K16/28
Filed: 2016-11-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau IIII1111111111111111111111111111111111111111111111111111111H111111111R111111111111111 (10) International Publication Number WO 2017/087589 A2 WIPO I PCT (43) International Publication Date 26 May 2017 (26.05.2017) (51) International Patent Classification: BOUTTON, Carlo [BE/BE]; Technologiepark 21, 9052 C07K 16/28 (2006.01) C07K 16/18 (2006.01) Zwijnaarde (BE). (21) International Application Number: (72) Inventors; and PCT/US2016/062394 (71) Applicants (for NZ, US only): DOMBRECHT, Bruno (22) International Filing Date: 17 November 2016 (17.11.2016) VLERICK, David [BE/BE]; Technologiepark 21, 9052 Zwijnaarde (BE). [BE/BE]; Technologiepark 21, 9052 Zwijnaaarde (BE). (25) Filing Language: English (74) Common Representative: MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue, Rahway, New Jersey (26) Publication Language: English 07065-0907 (US). (30) Priority Data: (81) Designated States (unless otherwise indicated, for every 62/257,009 18 November 2015 (18.11.2015) US kind of national protection available): AE, AG, AL, AM, (71) Applicant (for all designated States except US): MERCK AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, SHARP & DOHME CORP. [US/US]; 126 East Lincoln BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, Avenue, Rahway, New Jersey 07065-0907 (US). DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (72) Inventors; and KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (71) Applicants (for NZ, US only): BOWMAN, Edward MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, [US/US]; 901 S. California Avenue, Palo Alto, California OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 94304 (US). BEAUMONT, Maribel [FR/US]; 901 S. SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, California Avenue, Palo Alto, California 94304 (US). TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (72) Inventors; and ZW. (71) Applicants (for US only): BUYSE, Marie-Ange [BE/BE]; Technologiepark 21, 9052 Zwijnaarde (BE). [Continued on next page] (54) Title: PD1 AND/OR LAG3 BINDERS Cancer Patient Sera • • • 350 300 co - tp 0 250 co 200 CNI 150 100 W O 20 17 /0875 89 A2 • • 1013700112 F023700924 F023700931 FIG.19C (57) : The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, option- ally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing anti - bodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided. WO 2017/087589 A2MIDEDIM0111 DIOIRDIDEM11111111111111111111111111111111111111111111111111111 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g)) with sequence listing part of description (Rule 5.2(a))