baber/WOPTO huggingface dataset:
Patent CA-2452202-A1 (CA)
Title: Diagnostic methods and agents
Inventor: BERNARD ORA
IPC: C12Q1/68
Filed: 2002-06-27
Abstract: The present invention relates generally to a method for detecting an aberran t cell in a subject or in a biological sample from said subject and agents useful for same. The presence of the aberrant cell or group of aberrant cell s provides an indication of a particular disease or condition or a propensity for development of a disease or condition. More particularly, the present invention contemplates a method for detecting a cell associated with cancer or having a propensity to develop into a cancer cell in a subject or in a biological sample from said subject by determining the relative increase in the presence of a LIM kinase protein or a related enzyme or a relative increase in LIM kinase activity or a relative increase in the presence of expression products from a gene encoding a LIM kinase or a related protein. The present invention further provides a method for diagnosing the presence of a cancer or cancerous-like growth or distinguishing between an invasive and non-invasive cancer in a subject or in a biological sample from said subject by screening for up-regulation of a LIM kinase or a related protein in a cel l or group of cells or an up-regulation in the presence of expression products of genetic sequences encoding a LIM kinase or a related protein. The present invention provides diagnostic agents useful for detecting LIM kinase or expression products of genetic material encoding LIM kinase. Such diagnostic agents include immunointeractive molecules, such as antibodies, and genetic probes for detecting expression products of LIM kinase genes. The present invention further provides genetically modified animals exhibiting altered levels of LIM kinase. Such animals are useful models for screening for anti- cancer agents.
Patent CA-2453326-A1 (CA)
Title: Method and system for estimating weights of mailpieces
Inventor: MILLER JOHN P
IPC: G01G19/00
Filed: 2003-12-16
Abstract: A weight estimating system for estimating the weight of a mailpiece and a postage metering system including such a weight estimating system. The weight estimating system includes a measuring system, a diverter mechanism and a microprocessor system. The measuring system includes a transport, a first plurality of detectors for measuring the dimensions of the mailpiece and a second plurality of detectors for measuring values of other characteristics of the mailpiece which are indicative of the presence of non- paper materials in the mailpiece as the mailpiece is transported. The microprocessor is responsive to the second detectors to determine if non- paper materials are included in the mailpiece and, if riot, determines the volume from the dimensional measurements and estimates the weight as the product of the volume and a density for paper output an appropriate postage amount to the meter and the mailpiece to the printer. The postage metering system prints the mailpiece with a postal indicium and accounts for the postage amount expended. Otherwise the microprocessor controls the diverter mechanism to reject the mailpiece for separate processing.
Patent CA-2457905-A1 (CA)
Title: Procede de fabrication de capteur d'image couleur avec ouvertures de contact creusees avant amincissement
Inventor: POURQUIER ERIC
IPC: H01L31/0216
Filed: 2002-08-30
Abstract: L'invention concerne un procédé de fabrication d'un capteur d'image en couleurs. Le procédé comprend: la formation, sur la face avant d'une tranche semiconductrice (10), d'une serie de zones actives comportant des circuits d e détection d'image et correspondant chacune à un capteur d'image respectif, chaque zone active étant entourée de plots d'entrée/sortie (22); le report d e la tranche par sa face avant contre la face avant d'un substrat de support (20); l'élimination de la majeure partie de l'épaisseur de la tranche semiconductrice, laissant subsister sur le substrat une fine couche semiconductrice (30) comprenant les circuits de détection d'image. De plus, d'une part on dépose et on grave ensuite des couches de filtres colores (18) sur la tranche semiconductrice ainsi amincie, d'autre part, préalablement au report de la tranche semiconductrice sur le substrat, on a formé sur la face avant de la tranche semiconductrice des ouvertures métallisées (25) s'étenda nt plus profondément que les éléments des circuits de détection d'image formes à la surface de la tranche semiconductrice ; et l'étape d'amincissement compor te la mise à nu par l'arrière de la métallisation (22) des ouvertures métallisé es.
Patent CA-2458032-A1 (CA)
Inventor: WEBER GUENTHER
IPC: B65G47/71
Filed: 2002-09-04
Abstract: The invention relates to a distribution device for products, comprising a supply belt (Z) and a delivery belt (A), which are arranged one behind the other in the direction of transport. At least one distribution belt (V), whi ch can be displaced transversally in relation to the direction of transport, is located between the supply belt (Z) and the delivery belt (A). The distribution belt (V) is divided in two in the direction of transport.</SDOA B>
Patent CA-2461375-A1 (CA)
Title: Cea binding agents compositions to reverse cea-mediated tumorigenic effects on human cancer cells, restore sensitivity to drug induced apoptosis and uses thereof
Inventor: STANNERS CLIFFORD P
IPC: A61K38/08
Filed: 2004-04-02
Abstract: The present invention relates to differentiation, apoptosis and tumorigenicity. The present invention more particularly relates to compositions comprising ligands which target CEA such that the adhesion, differentiation-Inhibitory and apoptosis-resistance activities (tumorigenic effects) of Ig superfamily member, CEA, can be reduced or blocked. More particularly, the present invention relates to CEA-binding agents comprising compositions which reverse the CEA-mediated tumorigenic effects and enable a lowering of the doses of a chemotherapeutic agent. In one embodiment the invention relates to methods of reducing, preventing or reversing CEA-mediated tumorigenic effects comprising a use of an amount of a CEA declustering agent comprising compositions that can reverse a CEA mediated tumorigenic effect. In one embodiment, the invention further relates to compositions comprising a CEA declustering agent for reversing CEA-mediated tumorigenic effects and restoring drug induced apoptosis to human cancer cells and uses thereof.
Patent CA-2461739-A1 (CA)
Inventor: ZERWEKH WILLIAM D
IPC: G07C9/00
Filed: 2002-09-27
Abstract: A method and system (12) for detecting and monitoring noncompliant interstate transportation of materials is disclosed. The method and system (12) include providing a detection and monitoring network (8) whereby multiple ports-of-entry (10) are each equipped with a detection system that is in communication with a central computer (22). The detection systems are then used to detect levels of a material in vehicles passing through the ports-of-entry. The method and system (12) further including associating the levels of material detected for each vehicle with the respective vehicle, and saving the vehicle material levels on a computer (16). The material levels detected at each port-of-entry are then uploaded to the central computer (22) for monitoring and review.
Patent CA-2467374-A1 (CA)
Inventor: NAZARE MARC
IPC: A61K31/4439
Filed: 2002-11-08
Abstract: The present invention relates to compounds of the formula (I), in which R0;  R1; R2; R3; R4; R5; R6; R7; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
Patent CA-2467635-A1 (CA)
Title: Power management system for a floor care appliance
Inventor: SCLAFANI ADAM CHARLES
IPC: H02P5/46
Filed: 2004-05-19
Abstract: A floor care appliance is provided with an improved power management system for controlling the total amount of current provided to at feast a first and a second load device of an appliance. The power management system is comprised of a microprocessor, an alternating current voltage source, a voltage regulating circuit, a clamping circuit, at least two load devices, and a MOC and a triac for each of the at least two load devices. The clamping circuit outputs a fixed voltage of 5.7 volts during the positive portion of the ac cycle and a fixed voltage of -0.7 volts during the negative portion of the ac cycle. The fixed voltages are input to a microprocessor which utilizes these inputs to control the average voltage and the amount of time the current is turned on to each of the at least first and second load devices. A current sensing circuit is used to monitor the current to one of the at least two load devices to provide feedback to the microprocessor so that the microprocessor can adjust the average voltage and current to the at least two load devices so that the total current consumed does not exceed a pre-determined level.
Patent CA-2468447-A1 (CA)
Title: Porte-cycles soutenu par tete de fourche
Inventor: HAMMOND MALCOLM T
IPC: B60R9/06
Filed: 2004-06-03
Abstract: Porte-vélo monté sur véhicule pour transporter les cadres de vélo non standard, tels que les vélos tout terrain à suspension totale. Le porte-vélo est généralement monté sur la structure d'attelage d'un véhicule et se compose d'un mât de support vertical, avec une barre horizontale montée sur le dessus, équipée d'un berceau pour suspendre les vélos par leurs têtes de fourche en position verticale, offrant un accès indépendant. La conception du berceau permet d'orienter la fourche et le guidon de manière à éviter toute interaction avec le guidon d'un vélo adjacent, permettant ainsi l'espacement le plus étroit possible. Plus bas sur le mât de support vertical, se trouve une barre horizontale permettant de fixer les roues arrière du vélo, l'empêchant de se balancer sur les berceaux.
Patent CA-2469466-A1 (CA)
Title: Technique for effective management of information and communications using a mobile device
Inventor: LJUBICICH PHILIP A
IPC: H04L29/08
Filed: 2002-12-10
Abstract: A user of a mobile device, e.g., a WAP enabled wireless telephone (200), may call an information service for assistance, e.g., requesting desired telepho ne numbers, event schedules, movie listings, restaurant recommendations, etc. I n accordance with the invention, the requested information is organized and maintained for the user in a data location, e.g., a WAP site (405), which ca n be accessed by the user using the mobile device at the user's convenience. F or example, after accessing the previously requested listings on the WAP site (405), the user may utilize the mobile device (200) to initiate calls to selected telephone numbers, make reservation for selected events, or obtain directions to selected venues in such listings. In accordance with an aspect of the invention, when a call is connected through the information service, the user is afforded a first set of options displayed on the mobile device (200) for selection after the call is successfully completed. Otherwise, if the call cannot be successfully completed, the user is afforded a second set of displayed options to obtain further assistance from the information servi ce.
Patent CA-2469775-A1 (CA)
Inventor: DLUGAS WOLFGANG
IPC: H05B3/56
Filed: 2004-06-04
Abstract: An electric heating cable or an electric heating tape having insulating sheaths of polytetrafluoroethylene (PTFE) being arranged in a layered structure is provided.    At least one of the PTFE sheaths is protected against shock by at least one adjacent insulating layer of a melt processable fluoropolymer.
Patent CA-2470509-A1 (CA)
Title: Insect holder
Inventor: CHERRY KENNETH ALAN
IPC: A01K67/00
Filed: 2002-12-20
Abstract: An insect holder for holding an insect of a particular type, e.g. a forager honey bee, comprises a housing with a chamber adapted to receive an insect of the particular type, an inlet to the chamber through which an insect of the particular type can pass to enter the chamber, a head opening to the chamber adapted to permit the head of an insect of the particular type in the chamber to pass therethrough to the exterior of the housing while retaining the insect in the housing, and retaining means for retaining an insect of the particular type in the chamber with the head of the insect protruding through the head opening to the exterior of the housing, such that the insect is unable to turn around in the chamber. In use, an insect of the particular type enters the chamber via the inlet, and is then retained in the holder by the retaining means. The insect is retained in the chamber, with its head protruding through the head opening of the chamber. The insect is constrained to be unable to turn around in the chamber or withdraw its head into the chamber, so the head of the insect must remain outside the chamber. The insect is thus held in the holder with the head visible, so that observations can be made on the insect head, e.g. monitoring proboscis movement in known manner. When observations are finished, the retaining means can be removed or deactivated so that the insect is able to leave the chamber, with the insect unharmed and undamaged.
Patent CA-2471035-A1 (CA)
Inventor: DAY BILLY N
IPC: C12N15/85
Filed: 2002-12-23
Abstract: The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The invention provides viable gene knockout swine including swine in which the .alpha.(1,3)-galactosyltransferase gene has been disrupted, methods for making such swine, and methods of using the tissues and organs of such swine for xenotransplantation.
Patent CA-2472762-A1 (CA)
Title: 2-oxazolamines and their use as 5-ht2b receptor antagonists
Inventor: COLEMAN ROBERT ALEXANDER
IPC: A61P9/12
Filed: 2003-02-11
Abstract: The present invention relates to compounds of formula (I): wherein one of R1~and R4~ is selected from the group consisting of H, and optionally substituted C~1-6 alkyl, C~3-7 cycloalkyl, C~3-7 cycloalkyl-C~1-4 alkyl, and phenyl-C~1-4 alkyl; and the other of R1~ and R4~ is an optionally substitute d C~9-14 aryl group; R2~ and R3~ are either:(i) independently selected from H, R, R', SO~2R, C(=O)R, (CH~2)~nNR5~R6~, where n is from 1 to 4 and R5~ and R6 ~ are independently selected from H and R, where R is optionally substituted C ~1- 4 alkyl, and R' is optionally substituted phenyl-C~1-4 alkyl, or (ii) togeth er with the nitrogen atom to which they are attached, form an optionally substituted C~5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT~2B receptor.
Patent CA-2473528-A1 (CA)
Title: Fluorine gas treatment of washing machine parts
Inventor: FLOWERS CHRISTOPHER L
IPC: A47L15/42
Filed: 2004-07-09
Abstract: Plastic components exposed to a washing chamber of a washing machine are treated with a fluorine-containing gas mixture for improving the stain resistance and drying performance of the plastic components. In accordance with the invention, a plastic component is placed in a reaction chamber and exposed to a gas mixture containing fluorine and oxygen for a sufficient amount of time for the gas mixture to react with the plastic component such that the gas mixture modifies at least a surface layer, thereby enhancing the resistance of the plastic component to staining, while improving drying performance characteristics. Plastic dishwasher components that may be treated by the gas mixture include a dishwasher tub, a door liner, spray arms, racks, silverware baskets, a pump housing, and the like. Washing tubs, agitators, baffles and the like of clothes washing machine could also be advantageously treated.
Patent CA-2474138-A1 (CA)
Title: Composition and imaging methods for pharmacokinetic and pharmacodynamic evaluation of therapeutic delivery system
Inventor: HALLAHAN DENNIS E
IPC: A61K51/00
Filed: 2003-01-15
Abstract: A halogen-labeled gene therapy construct that includes halogen labeled nucle ic acids, methods for preparing a halogenated gene therapy construct, and metho ds for in vivo imaging of the same. Also provided are methods for non-invasive drug detection in a subject using a labeled antibody that recognizes a heterologous antigen conjugated to, encoded by, or otherwise associated with the drug.
Patent CA-2478719-A1 (CA)
Title: Photopolymerizable composition and photopolymerizable film prepared therefrom
Inventor: PARK JI YOUNG
IPC: C08L33/00
Filed: 2004-01-10
Abstract: A photopolymerizable composition of the present invention, comprising a specific acryl- or methacryl-based compound in combination with a binder which is a siloxane precursor-containing sol-gel solution or a transparent polymer resin, can provide a photopolymerizable film having an improved recording property when photocured.
Patent CA-2486037-A1 (CA)
Title: Pattern selector valve for control levers of a work vehicle
Inventor: MEYERES RIAN SCOT
IPC: E02F9/20
Filed: 2004-10-22
Abstract: A backhoe control pattern selection arrangement is provided for a backhoe controlled by two control levers. The two levers are operatively connected to hydraulic systems that operate the boom and crowd hydraulic cylinders. An electrically operated valve block is electrically connected to a source of power and to a control switch, and hydraulically connected to the hydraulic systems. Changing the state of the control switch actuates the valve block and modifies the hydraulic systems to reverse the correspondence between the control levers and the boom and crowd functions.
Patent CA-2487557-A1 (CA)
Inventor: SLEEMAN MATTHEW
IPC: C07K14/715
Filed: 2003-05-27
Abstract: Isolated fibroblast growth factor receptor (FGFR5) polypeptides and polynucleotides encoding such polypeptides are provided. Also provided are modulators of FGFR5 gene expression and binding molecules that specifically bind to and agonize or antagonize FGFR5 polypeptide function. Specific binding molecules include antibodies, functional fragments thereof, as well as scFv and Camelidae heavy chain IgG that specifically bind to FGFR5 thereby modulating the activity of FGFR5 and, thus, are effective agents suitable for the treatment of diseases such as osteopontin-mediated autoimmune disease, such as systemic lupus erythematosus, bone disorders including osteoporosis and osteopetrosis, and cancers, including cellular carcinomas such as hepatocellular carcinomas.
Patent CA-2489477-A1 (CA)
Title: Device for enabling reduced motion-related artifacts in parallel magnetic resonance imaging
Inventor: SUSSMAN MARSHALL STEPHEN
IPC: G01R33/3415
Filed: 2004-11-25
Abstract: The present invention provides several embodiments of a device for physically separating RF imaging coils from any source of movement thereby minimizing potential coil-displacement related reconstruction effect or artifact. The device can be used to enable parallel imaging of the abdomen, pelvis and other moving body parts such that normal or abnormal patient movement does not displace the coil elements between the calibration scan and the subsequent imaging scans.
Patent CA-2491370-A1 (CA)
Inventor: ENDICO FELIX W
IPC: A23L27/60
Filed: 2004-12-31
Abstract: A process for making a freezably stable emulsion based food salad. A freezing point depression agent, such as propylene glycol, is added to a water component of the emulsion to prevent the formation of ice crystals during freezing of the non-aqueous salad components and to prevent oil separation upon thawing. A hardenable oil such as partially hydrogenated soybean oil, provides an elevated emulsion melt point.  Microbial control is maintained during processing by oxygenating the water component.  The frozen food salad may be containerized for shipping or used as a frozen sandwich filling.
Patent CA-2493942-A1 (CA)
Inventor: MASON RALPH DICKSON
IPC: H03L7/24
Filed: 2003-08-11
Abstract: The invention relates to the field of electronics and more particularly to t he tuning and injection locking of voltage controlled oscillators (VCOs). An improved injection locking circuit is provided which allows the VCO to injection lock with a smaller reference signal and therefore a smaller locki ng bandwidth (LBW). In order to allow the VCO to injection lock with a lower power reference signal, this invention includes a pre-tuning STEP to place t he VCO frequency such that the desired frequency is in the LBW. Tuning of the V CO is achieved using direct digital tuning that does not require an input reference. Injection locking is performed using a low frequency clock harmon ic as the reference signal. More specifically, tuning is accomplished by sub- sampling and digitizing the output signal of the VCO, determining the center frequency, and adjusting the VCO control voltage.
Patent CA-2494404-A1 (CA)
Title: Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
Inventor: ZANON JACOPO
IPC: C07C253/30
Filed: 2003-07-31
Abstract: One aspect of the present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-sulfur bond between the sulfur atom of a thiol moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper(II)-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-carbon bond between the carbon atom of cyanide ion and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In another embodiment, the present invention relates to a copper-catalyzed method of transforming and aryl, heteroaryl, or vinyl iodide. Yet another embodiment of the present invention relates to a tandem method, which may be practiced in a single reaction vessel, wherein the first step of the method involves the copper-catalyzed formation of an aryl, heteroaryl, or vinyl iodide from the corresponding aryl, heteroaryl, or vinyl chloride or bromide; and the second step of the method involves the copper-catalyzed formation of an aryl, heteroaryl, or vinyl nitrile, amide or sulfide from the aryl, heteroaryl, or vinyl iodide formed in the first step.
Patent CA-2495199-A1 (CA)
Title: Synergistic organoborate compositions and lubricating compositions containing same
Inventor: KAROL THOMAS J
IPC: C10M141/12
Filed: 2003-10-02
Abstract: An additive for imparting antiwear properties to a lubricant composition is based on a combination of (1) an organo borate ester composition and (2) one or more sulfur-or phosphorus-containing compounds or a non-sulfur molybdenum compound. The sulfur-or phosphorus-containing compounds are dithiocarbamate, bisditiocarbamate, 1,3,4-diathiazole, phosphoroditioate, phosphoroditioate esters, and the molybdenum compound is prepared by reacting (a) about 1.0 mole of fatty oil having 12 or more atoms (b), about 1.0 to 2.5 moles diethanolamine and (c) a molybdenum source.