baber/WOPTO huggingface dataset:
Patent DE-69416629-T2 (DE)
Inventor: SUGIHARA HIROSADA
IPC: A61K38/00
Filed: 1994-06-13
Granted: 1999-07-22
Abstract: Compounds of the formula <CHEM> [wherein A represents amidino group or an optionally substituted aminoethyl; R<1><0> represents one species selected from a group consisting of nitro group, a halogen atom, a lower alkenyl group, a lower alkynyl group, a lower alkyloxycarbonyl group and a group represented by the formula OR<1><1> (wherein R<1><1> is hydrogen atom or a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkanoyl group, a carbamoyl group or a methanesulfonyl group, each of which may be substituted; R<1><2> and R<1><3> respectively represent hydrogen atom, hydroxyl group, a lower alkoxy group or a halogen atom; X represents hydroxyl group, p-hydroxyphenyl group or an optionally esterified or amidated carboxyl group; Y represents an optionally esterified or amidated carboxyl group; and n denotes 1 or 2], or a salt thereof and agent for inhibiting adhesion of cells, which comprise said compound, and these have more potent and long lasting activities of inhibiting cell-adhesion, thus being useful as an orally administrable anti-thrombotic agent.
Patent DE-69416828-T2 (DE)
Inventor: CHANDLER HOWARD
IPC: B01L3/00
Filed: 1994-03-31
Granted: 1999-07-08
Abstract: A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynamic range and avoids interference from particulates or colored components. In one form, the device comprises: (1) a first opposable component comprising a sample preparation zone adapted to receive a sample to be assayed; and (2) a second opposable component comprising a chromatographic medium. The first and second opposable components can be brought into opposition so as to cause the sample preparation zone to apply the sample to be tested to the chromatographic medium. Preferably, the analyte is detected with a visually detectable label. Other variations of the device vary the arrangement of components to provide optimal chromatography for a variety of analytes, as well as to permit bidirectional chromatography; still other variations are suitable for competitive immunoassays. The devices can be incorporated in test kits, and assay methods, both sandwich and competitive, using the devices are also disclosed.
Patent DE-69421343-T2 (DE)
Inventor: SHIMIZU YASUHIKO
IPC: A61F2/04
Filed: 1994-08-03
Granted: 2000-03-30
Abstract: There are disclosed a material for medical use comprising two sheets of collagen membrane adhered to each other with an adhesive and having interposed therebetween a mesh-like intermediary material, wherein the mean pore size of the mesh-like intermediary material is between 100 and 2000  mu m; and a process for preparing a material for medical use comprising (a) laminating with an adhesive two sheets of a collagen membrane having a mesh-like intermediary material interposed therebetween; (b) maintaining the resulting laminated material under a reduced pressure so that the two sheets of collagen membrane are adhered to each other through the mesh-like intermediary; and (c) cross-linking the laminated material.
Patent DE-69429812-T2 (DE)
Inventor: ASAFOV ALEXANDR VILENOVICH
IPC: A61Q19/00
Filed: 1994-04-14
Granted: 2002-08-14
Abstract: The present invention relates to low-molecular DNA extracted from sturgeon milt and to a pharmaceutical preparation on its base. The invention also discloses a method for preparation of low-molecular DNA from sturgeon milt. A description is given of a new preparation based on low-molecular DNA for use in the capacity of a hemocorrector, inhibitor of viral activity, particularly HIV infection, and for treating lesions of the mucous membrane of different etiologies. Also disclosed is the use of low-molecular DNA as a universal cosmetic addition.
Patent DE-69431105-T2 (DE)
Inventor: LAU KWOK-LEUNG
IPC: C08K5/3435
Filed: 1994-03-23
Granted: 2003-03-13
Abstract: A light stabilizer package is disclosed. The light stabilizer package comprises a monomeric HALS having a pKa of no greater than 7, an ultraviolet light absorber and, optionally, a polymeric HALS having a pKa of less than 7. The light stabilizer package may be blended with a thermoplastic olefin to form a moldable light stable composition. An article comprising the moldable light stable composition may have an exterior surface that is at least partially coated.
Patent DE-69433425-T2 (DE)
Inventor: PADHYE V
IPC: C12Q1/6806
Filed: 1994-08-30
Granted: 2004-10-07
Abstract: The present invention provides compositions and methods for isolating nucleic acids with lengths greater than about 50 bases, from cells, gels, solutions and other media, in which nucleic acids occur in vivo or in vitro. The compositions of the invention are mixtures of the silica materials silica gel and glass particles, particularly glass microfibers; such mixtures combined with chaotropic salts, such as guanidinium chloride or guanidinium thiocyanate; and suspensions of such mixtures in aqueous solutions of chaotropic salts. In the methods of the invention, an aqueous solution comprising nucleic acid is mixed with an aqueous solution of chaotropic salts and the resulting solution is contacted with a mixture of the silica materials, whereupon the nucleic acid in the solution binds to the silica materials. The chaotropic salts and components, other than the nucleic acid adsorbed to the silica materials, from the aqueous solution treated by the method of the invention are washed from the silica materials. Finally, the nucleic acid can be obtained by elution from the silica materials. The methods provide nucleic acid in water or buffer, such as TE buffer, free of contamination by any salt or macromolecule that would interfere with further processing or analysis.
Patent DE-69504766-T2 (DE)
Inventor: TAKEUCHI ESTHER S
IPC: H01M4/06
Filed: 1995-06-21
Granted: 1999-02-04
Abstract: A new cathode material for use in a high energy density electrochemical cell, preferably comprising silver and vanadium, is described. The new cathode material has the general formula AgxV2Oy and can comprise a  beta -phase silver vanadium oxide having in the general formula x = 0.35 and y = 5.18 and a  gamma -phase silver vanadium oxide having in the general formula x = 0.74 and y = 5.37 or a mixture of the phases. This new cathode material exhibits reduced voltage delay during high rate applications, such as when the cathode mixture is incorporated into a primary lithium electrochemical cell powering an implantable cardiac defibrillator. <IMAGE>
Patent DE-69505795-T2 (DE)
Inventor: VELDKAMP JEROEN
IPC: A23L19/20
Filed: 1995-03-02
Granted: 1999-04-29
Abstract: PCT No. PCT/NL95/00078 Sec. 371 Date Oct. 8, 1996 Sec. 102(e) Date Oct. 8, 1996 PCT Filed Mar. 2, 1995 PCT Pub. No. WO95/23516 PCT Pub. Date Sep. 8, 1995The invention relates to a method for the production of an optionally preserved, water- and/or oil-containing foodstuff such as vegetables, pulses and fruit, which a casein compound which is soluble in water and/or oil or has been dissolved in water and/or oil is added to the foodstuff before, during or after the preparation or sterilisation, a closed container, containing a foodstuff which has been prepared according to this method, as well as the use of a casein compound which is soluble in water, or has been dissolved in water, to improve the appearance of optionally preserved water- and/or oil-containing products.
Patent DE-69511938-T2 (DE)
Inventor: CAISEY LAURENCE
IPC: D06L4/50
Filed: 1995-05-04
Granted: 2000-05-04
Abstract: Process and device for the cosmetic partial or complete lightening of hair comprises irradiating the hair with a laser beam with impulses at a frequency of ≥ 10 Hz which degrades the melamine in the hair. Locks of hair are passed repeatedly through the laser beam until the desired colour is obtained. During treatment the hair is cooled to prevent heat damage. <IMAGE>
Patent DE-69514866-T2 (DE)
Inventor: CRUDDEN JOSEPH J
IPC: C07C233/47
Filed: 1995-06-01
Granted: 2000-07-27
Abstract: Non-aq. neutralisation of N-acyl sarcosines (I) is performed by using caustic (II) under high shear conditions. Pref. (II) is KOH or esp. NaOH either in anhydrous form, or with water content pref. less than 20 (esp. ca. 4)%.
Patent DE-69533357-T2 (DE)
Inventor: LJUNGSTROEM BO
IPC: B65D5/06
Filed: 1995-05-02
Granted: 2005-09-22
Abstract: A gable top carton and its corresponding carton blank are disclosed. The carton includes curved side creases that are defined by curved score lines that divide one or more side panels from a top gabled structure and/or a bottom structure.
Patent DE-69601722-T2 (DE)
Inventor: QUINN HUBERT
IPC: B01D15/14
Filed: 1996-11-01
Granted: 1999-07-29
Abstract: A method of and apparatus for liquid chromatography at improved analytical and preparative speeds and quantities involves flow of fluids through the column at flow rates sufficient to induce turbulent flow in those fluids. In one embodiment, the apparatus and method includes a substantially uniform chromatography column created by packing together a multiplicity of rigid, solid, porous particles having diameters of not less than about 30  mu m, surfaces of the particles being chromatographically active. A fluid mixture containing at least one solute that is reactive with the particle surfaces is injected into the column and subsequently eluted therefrom by a eluant fluid flow, both the injection and elution being effected at a velocity sufficient to induce flow within at least a substantial portion of the interstitial volume between the particles at a reduced velocity greater than about 5,000.
Patent DE-69604074-T2 (DE)
Inventor: MARTINELLI ENZO
IPC: B41F15/38
Filed: 1996-06-28
Granted: 2000-01-27
Abstract: The machine comprises a screen (12) of drum form comprising two rigid annular elements (11), positioned on the two flat ends and arranged to maintain the screen surface under axial tension; there are also provided a horizontal outer shaft (21) rigid with the fixed structure (9) and projecting from it, and an inner shaft (22) coaxial with and movable axially relative to the outer shaft (21) and inserted telescopically into this latter, and having a front end (22') projecting from the front end of the outer shaft (21); a first group (41) of radial means being fixed to the end (22') of the inner shaft (22); a second group (42) of radial means being rotatably and coaxially coupled to the outer shaft (21); said groups (41, 42) of radial means being arranged to press axially against the two annular elements (11) of the drum (10) in such a manner as to withdraw them from each other in an axial direction; a thrust means (30) being provided to move the inner shaft (22) axially to the outer shaft (21), and a motion transmission system for rotating with the same motion both the groups (41, 42) of radial means.
Patent DE-69609123-T2 (DE)
Inventor: CROCCO GUY L
IPC: C07B61/00
Filed: 1996-05-17
Granted: 2001-03-01
Abstract: A titanium-containing molecular sieve which has been used as an epoxidation catalyst is regenerated to provide a level of performance comparable to that of freshly prepared catalyst by heating at less than 400 DEG C in the presence of molecular oxygen. The same batch of catalyst thus may be used over an extended period of time in a continuous epoxidation process by periodic practice of the aforedescribed reactivation method.
Patent DE-69616310-T2 (DE)
Inventor: MURPHY JAMES C
IPC: B29C53/58
Filed: 1996-08-28
Granted: 2003-01-09
Abstract: The invention relates to a method of manufacturing a fluid containing vessel having a fitting. The steps include forming a liner (10), providing a preformed fitting (14) having a flange; installing an insert (24) in the fitting; and positioning the fitting (14) on a wall of the liner (10) and welding the insert to the wall. Additional steps include filament winding the liner, said filaments capturing the fitting flange against the wall; and cutting a hole through the wall of the liner inside the fitting to create a passage through the fitting and liner wall. Preferably, the fitting (14) defines a passage (18) therethrough and the insert (24) is installed in the passage (18). The insert preferably has a flange (26) that engages the fitting to retain the fitting on the liner. The passage preferably communicates with an interior of the liner through the hole. When the liner and insert are made of materials having substantially similar melting temperatures, they are preferably heated to about the same temperature. When the liner (10) and insert (24) have different melting temperatures, they are preferably heated to different temperatures. The liner 10) and insert (24) are preferably made of materials compatible for welding to each other, preferably plastic. The liner (10) may be generally cylindrical, and the fitting (14) may be located on a generally cylindrical side wall of the liner. The step of welding may include heating the insert (24) and an area of the liner (10) and pressing the insert (24) into the liner to bond therewith. <IMAGE>
Patent DE-69619977-T2 (DE)
Inventor: ARIAS LUIS
IPC: H04H20/00
Filed: 1996-05-23
Granted: 2002-11-07
Abstract: Apparatus for and a method of asymmetric communication is disclosed wherein, in a programme subsystem (10) is equipped to receive television and/or data content from various sources (12,14) and provide received content in an appropriate form (18) for transmission, a transmitter subsystem (20) is operatively connected to the programme subsystem and including transmission equipment for generating one or more signals to reach a set of subscribers (30), receiving (131) and processing (100) equipment at subscriber premises (32) enables subscribers to select from among the variety of content carried by the signals and an asymmetric return path facility (50) is linked to the processing equipment by a communication network (40, 45) separate and distinct from the transmitter subsystem and to the programme subsystem for reception of subscriber communications.
Patent DE-69629657-T2 (DE)
Inventor: DENIEGA C
IPC: B01D61/18
Filed: 1996-05-22
Granted: 2004-06-09
Abstract: The method comprises adding to the whole blood, prior to separation, an anticoagulant solution comprising citric acid, trisodium citrate and dextrose and no phosphate, and storing the separated red blood cells in a storage solution comprising dextrose, adenine, mannitol and sodium chloride.
Patent DE-69636531-T2 (DE)
Inventor: BRODER SAMUEL
IPC: A61K38/54
Filed: 1996-10-24
Granted: 2006-12-07
Abstract: A method of increasing the bioavailability upon oral administration of a pharmacologically active target agent, particularly an antitumor or antineoplastic agent which exhibits poor or inconsistent oral bioavailability (e.g., paclitaxel, docetaxel or etoposide), comprises the oral co-administration to a mammalian patient of the target agent and an oral bioavailability-enhancing agent (e.g., cyclosporin A, cyclosporin D, cyclosporin F or ketoconazole). The enhancing agent may be administered orally from 0.5-24 hrs. prior to the oral administration of one or more doses of the target agent, substantially simultaneously with the target agent or both prior to and substantially simultaneously with the target agent. A method of treating mammalian patients suffering from diseases responsive to target agents with poor oral bioavailability, as well as oral dosage forms containing such target agents, combination oral dosage forms containing bioavailability-enhancing agents and target agents and kits containing enhancing and target agent dosage forms and dosing information for the co-administration of the same are also disclosed.
Patent DE-69701158-T2 (DE)
Inventor: DELASSUS PIERRE
IPC: B22D11/06
Filed: 1997-02-07
Granted: 2000-09-14
Abstract: The cylinder consists of a hub (2), a coaxial shell (3) and two supporting and centering flanges (5,6) between them. Each flange has a truncated conical surface (51,61) which engages with a corresponding surface (34,35) on the inside of the shell situated in a zone in which variations in the shell's inner diameter as a result of expansion are virtually nil. The flanges are pressed towards one another by springs (74), and the hub and shell also have axial stops (24,33) and pressure elements (80,81). The flanges and the shell have connecting channels (7,8,53,54) for circulating a coolant, with additional channels (32) in the shell located in the outer of its two layers (37).
Patent DE-69705569-T2 (DE)
Inventor: WILDERBEEK ANTONIUS THEODORUS
IPC: A61K9/16
Filed: 1997-03-05
Granted: 2002-05-16
Abstract: The present invention relates to a vaccine container that contains one or more freeze-dried vaccine components. The vaccine component or components are present in two or more freeze-dried bodies, at least one of which is a lyosphere. Furthermore, the invention relates to methods for the preparation of such a vaccine container. Also, the invention relates to a vaccine pack, comprising the vaccine container.
Patent DE-69707769-T2 (DE)
Inventor: RIONDEL M ALAIN
IPC: C07C219/08
Filed: 1997-06-26
Granted: 2002-07-11
Abstract: Aqueous stabilised unsaturated quaternary ammonium salt(s) of the following formula( I), R1 = H or Me; R = Me or benzyl; X = Cl, Br, I or -CH3-SO4, obtained by the reaction, in the presence of water, of N,N-dimethylaminoethyl (meth)acrylate of formula (II), with a quaternising agent of formula R-X (III), with R and X as above. The solution contains a stabiliser associated with the monomer (II) and also a metal sequestering agent chosen from diethylenetriamine penta-acetic acid, its pentasodium salt, N-hydroxyethyl-ethylenediamine triacetic acid and is trisodium salt. Also claimed, is their method of preparation.
Patent DE-69722281-T2 (DE)
Inventor: MACKENZIE ALEXANDER RODERICK
IPC: A61P25/26
Filed: 1997-01-20
Granted: 2003-11-27
Abstract: Compounds of the formula: <CHEM>  wherein: X is O, NH or NR<1>; R<1> is C1-C6 alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl(C1-C4)alkyl, aryl or aryl (C1-C4)alkyl; wherein the C1-C6 alkyl group is optionally substituted by fluorine and the C3-C7 cycloalkyl or C3-C7 cycloalkyl(C1-C4)alkyl group is optionally substituted in the cycloalkyl ring by up to two substituents each independently selected from halo, C1-C4 alkoxy or halo(C1-C4)alkoxy; R<2> is phenyl optionally substituted with one or two halo substituents, indolyl or thienyl; R<3> is NH2, -NR<4> SO2(C1-C6 alkyl), -NR<4>SO2 aryl, -NR<4>CO(C1-C6 alkyl), -NR<4>CO aryl or a 5 to 7-membered N-linked cyclic group incorporating W in the ring wherein W is O, NR<5>, CH(OH), CHCO2H, CHN(R<4>)2, CHF, CF2, C = O or CH2; R<4> is H or C1-C6 alkyl; R<5> is H, C1-C6 alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl(C1-C6)alkyl, C2-C6 alkanoyl, C4-C8 cycloalkanoyl, C3-C7 cycloalkyl(C2-C6)alkanoyl, aryl CO-, C1-C6 alkyl SO2-, C3-C7 cycloalkyl SO2-, C3-C7 cycloalkyl(C1-C6)alkyl SO2-, aryl-SO2- or (R<6>)2NSO2-, wherein each R<6> is independently H or C1-C4 alkyl or the two groups may be joined to form with the nitrogen atom to which they are attached, a pyrrolidinyl, piperidino, morphlino or piperazinyl group; m is O, 1 or 2 with the proviso that m is not O when W is NR<5>, C=O, or O; and n is an integer of from 1 to 4; are neurokinin receptor antagonists of utility in the treatment of a variety of medical conditions including urinary incontinence, asthma and related conditions.
Patent DE-69731330-T2 (DE)
Inventor: TIAN SIMON
IPC: H02H3/33
Filed: 1997-06-13
Granted: 2005-11-03
Abstract: The differential protection device includes principal contacts (2) which interrupt the electricity supply circuit fed from conductors (3,P,N). The conductors pass through the core of a differential fault current sensor (4), which is connected to a processing unit (12). A trigger relay (7) connected to the processing unit (12) controls the opening of the principal contacts (2) if a differential fault is detected. An AC/DC converter which provides a supply voltage (V) to the protection device is connected to the conductors and the processing unit (12). The protection device also includes: a supervisory device (15) which monitors the supply voltage (V) which feeds the processing unit (12); and a control relay (14) connected to the supervisory device (15) which controls as a function of the supply voltage the opening and closing of the contacts (2,13) in the principal circuit. Closure of the principal circuit by the control relay (14) is prevented if the trigger relay (7) is activated. The supervisory device (15) includes a comparator whose output controls opening of contacts (2,13) of the principal circuit if the supply voltage (V) is less than a first predetermined step value or controls closing of the contacts if the voltage is greater than a second predetermined step value. The protection device also includes a device (17) for storing the electrical energy connected to the supply circuit (8).
Patent DE-69732305-T2 (DE)
Inventor: HELLER J
IPC: B01L3/00
Filed: 1997-11-26
Granted: 2006-04-06
Abstract: This invention relates to techniques which utilize programmable functionalized self-assembling nucleic acids, nucleic acid modified structures, and other selective affinity or binding moieties as building blocks. The invention is a method for the fabrication of micro scale and nanoscale devices comprising the steps of: fabricating first component devices on a first support, releasing at least one first component device from the first support, transporting the first component device to a second support, and attaching the first component device to the second support. The invention also provides for orienting a structure in an electric field, reacting affinity sequences, and assembling chromophoric structures by photoactivation.
Patent DE-69808064-T2 (DE)
Inventor: CAMPBELL WILBERT
IPC: B01J/
Filed: 1998-04-16
Granted: 2003-05-22
Abstract: A method of making a bonded, coherent material comprising a mass of diamond crystals in a matrix, which optionally contains another phase. The method includes the steps of providing a source of diamond crystals, providing a plurality of diamond centers defined by diamond crystals, producing a reaction mass by bringing the source and growth centers into contact with a solvent/catalyst, subjecting the reaction mass to conditions of elevated temperature and pressure suitable for crystal growth in the reaction zone of a high temperature/high pressure apparatus to produce the material, and removing the material from the reaction zone. The method is characterized by providing the necessary supersaturation of carbon in the solvent/catalyst, at least in part and preferably predominantly, by a selection of particle size difference between the source crystal and the growth centers. The mass of diamond crystals in the matrix of the bonded, coherent material of the invention has a high concentration of twinned diamonds.
Patent DE-69810470-T2 (DE)
Inventor: KOMISAK JAN
IPC: B62D51/04
Filed: 1998-06-24
Granted: 2003-11-06
Abstract: This invention relates to the equipment in the casing (1) of which a gearbox (6) driven by the motor (2) is situated whereby on the outer side of the casing (1) a sectional feeding belt is situated. The mentioned equipment has got several modification possibilities as e.g. tow, ropeway, wheeled vehicle etc.
Patent DE-69812654-T2 (DE)
Inventor: DELUCA F
IPC: A23K1/16
Filed: 1998-07-01
Granted: 2003-09-25
Abstract: An animal feed containing a carboxylic acid either as the sole active ingredient or in combination with 1 alpha -hydroxylated vitamin D compounds and/or phytase. The carboxylic acid or the combination of carboxylic acid with vitamin D compounds and/or phytase causes improved utilization of phosphorus, calcium, potassium, magnesium, zinc, iron and manganese in animal feed so as to minimize, or perhaps eliminate, the need for supplemental quantities of these minerals in an animal diet. In addition, low phosphorus containing animal feeds reduce the polluting effects on the environment since less phosphorus is excreted in the animal's feces which are then spread on agricultural land.