baber/WOPTO huggingface dataset:
Patent DE-69434888-T2 (DE)
Inventor: KING FRANCIS DAVID
IPC: A61K31/435
Filed: 1994-05-16
Granted: 2007-06-14
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: <?in-line-formulae description="In-line Formulae" end="lead"?>X-CO-CH<SUB>2</SUB>-Z <?in-line-formulae description="In-line Formulae" end="tail"?> wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), (j) or (k): wherein n<SUP>1 </SUP>is 1, 2, 3 or 4; n<SUP>2 </SUP>is 0, 1, 2, 3 or 4; n<SUP>3</SUP>is 2, 3, 4 or 5; q is 0, 1, 2 or 3; p is 0, 1 or 2; m is 0, 1 or 2; R<SUB>5 </SUB>is hydrogen, C<SUB>1-2 </SUB>alkyl, aralkyl or R<SUB>5 </SUB>is (CH<SUB>2</SUB>)<SUB>z</SUB>-R<SUB>10 </SUB>wherein z is 2 or 3 and R<SUB>10 </SUB>is selected from cyano, hydroxyl, C<SUB>1-6 </SUB>alkoxy, phenoxy, C(O)C<SUB>1-6 </SUB>alkyl, COC<SUB>6</SUB>H<SUB>5</SUB>, -CONR<SUB>11</SUB>R<SUB>12</SUB>, NR<SUB>11</SUB>COR<SUB>12</SUB>, SO<SUB>2</SUB>NR<SUB>11</SUB>R<SUB>12 </SUB>or NR<SUB>11</SUB>SO<SUB>2</SUB>R<SUB>12 </SUB>wherein R<SUB>11 </SUB>and R<SUB>12 </SUB>are hydrogen or C<SUB>1-6 </SUB>alkyl; or R<SUB>5 </SUB>is straight or branched chain alkylene of chain length 1-6 carbon atoms terminally substituted by aryl, 3 to 8 membered cycloalkyl, 3 to 8 membered heterocyclyl, 5 or 6 membered monocyclic heteroaryl or 9 or 10 membered fused bicyclic heteroaryl linked through carbon, C<SUB>2-7 </SUB>alkoxycarbonyl, or secondary or tertiary hydroxy substituted C<SUB>1-6 </SUB>alkyl; ; and R<SUB>6</SUB>, R<SUB>7 </SUB>and R<SUB>8 </SUB>are independently hydrogen or C<SUB>1-6 </SUB>alkyl; and R<SUB>9 </SUB>is hydrogen or C<SUB>1-10</SUB>alkyl; and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
Patent DE-69509251-T2 (DE)
Inventor: MURPHY MAURICE WILLIAM
IPC: F16G11/00
Filed: 1995-10-24
Granted: 1999-11-25
Abstract: Methods and apparatus for forming devices including dead-ends and insulator ties from flat and other strips of material, as well as the devices themselves, are disclosed. Components of these devices may be formed continuously from a single strip, avoiding the need to weld or clamp the components together. Forming the devices in this manner reduces the possibility of stresses or non-uniformities forming when the components are joined and permits continuous automatic or semi-automatic manufacture to occur. <IMAGE>
Patent DE-69521913-T2 (DE)
Inventor: SILVEY L
IPC: B29C45/50
Filed: 1995-01-31
Granted: 2001-11-15
Abstract: A method for compensating for variations in the operating efficiency of electric motors used in plastic processing machines. The current to the motor is continually monitored during all periods of operation to identify variations in the motor's actual efficiency as it relates to measurable machine performance. Normal operation of the electric motor is monitored to establish baseline current usage for the various periods of the operating cycle under given conditions. With a baseline established, variations in motor efficiency can be detected by monitoring the current during closed loop control of specific parameters and comparing the results to the baseline. Since the parameter is held constant by virtue of the closed loop, a deviation in current from the baseline indicates a change in efficiency. Based on the identified variance, the current to the motor during other (open loop) operations can be adjusted accordingly.
Patent DE-69532855-T2 (DE)
Inventor: STIMPSON I
IPC: C12Q1/6825
Filed: 1995-09-20
Granted: 2005-03-24
Abstract: A waveguide binding assay method involves detecting the scattering of light directed into the waveguide, the scattering being the result of scattering labels specifically bound to the waveguide within the penetration depth of an evanescent wave. The waveguide may be transparent plastic or glass and the binding is typically by oligonucleotide hybridization or immunological capture. Light scattering labels include colloidal metals or non-metals, including gold, selenium and latex. A light absorbing member consisting of dye or concentrated particles may also be employed to enhance signal. Real-time binding and dissociation can be monitored visually or by video imaging, such as with a CCD camera and frame grabber software. Hybridization mismatches of as few as one base can be distinguished by real-time melting curves.
Patent DE-69533964-T2 (DE)
Inventor: ARNTZEN CHARLES J
IPC: C07K14/245
Filed: 1995-10-24
Granted: 2006-03-30
Abstract: The oral vaccines and oral vaccine adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents which are capable of causing an immune response in animals when fed in edible plants, plant tissues, or derived plant materials are constructed and plants transformed for stable or transient expression in plant cells. The present invention provides the first known functional method for immunizing animals via transgenic plants, where the plants express bacterial antigens that act as both immunogens and adjuvants when the transgenic plant material expressing the antigens is fed to animals.
Patent DE-69535075-T2 (DE)
Inventor: ROVINSKI BENJAMIN
IPC: C12N7/00
Filed: 1995-08-15
Granted: 2007-01-04
Abstract: PCT No. PCT/CA95/00483 Sec. 371 Date Jun. 2, 1997 Sec. 102(e) Date Jun. 2, 1997 PCT Filed Aug. 15, 1995 PCT Pub. No. WO96/05292 PCT Pub. Date Feb. 22, 1996The present invention is concerned with the ability to differentiate between infection by HIV and immunization with an immunogenic preparation. Accordingly, the present invention provides a non-infectious, non-replicating, HIV retrovirus-like particle containing a heterologous antigenic marker, comprising an assembly of (a) an env gene product; (b) a pol gene product; (c) a gag gene product; and, (d) at least one non-retroviral, non-mammalian antigenic marker. The antigenic marker may have between 10 and 75 amino acid residues. In one embodiment, the amino acid sequence contains a tobacco mosaic virus (TMV) epitope obtained from the coat protein. In another embodiment, the marker is inserted into the gag gene product at an antigenically-active insertion site. The presence of the antigenic marker enables recognition that antiserum containing anti-HIV antibodies has been generated by exposure to the non-infectious retrovirus-like particles, as opposed to wild-type HIV infection, by testing for antibodies specific to the antigenic marker.
Patent DE-69600269-T2 (DE)
Inventor: LEVERD RICHARD
IPC: A63F7/22
Filed: 1996-01-18
Granted: 1998-08-27
Abstract: The game has a housing (3) on four feet (2), each of which is formed by a hollow housing which is closed and made of plastics. The leg has an extension (7) extending upwardly with a seating (8) facing the same housing at the ends of the housings longitudinal and lateral sides (4,5). At the base of the seating are two sleeves to receive fastening rods (26,27) to retain the leg to the respective corner of the housing.
Patent DE-69613860-T2 (DE)
Inventor: BARTH FRANCIS
IPC: A61P43/00
Filed: 1996-11-21
Granted: 2002-04-04
Abstract: PCT No. PCT/FR96/01847 Sec. 371 Date May 19, 1998 Sec. 102(e) Date May 19, 1998 PCT Filed Nov. 21, 1996 PCT Pub. No. WO97/19063 PCT Pub. Date May 29, 1997Compounds of formula (I), wherein R1 is fluorine, hydroxy, (C1-5) alkoxy, (C1-5) alkylthio, hydroxy(C1-5)alkoxy, a -NR10R11, group, cyano, (C1-5) alkyl-sulphonyl or (C1-5) alkylsulphinyl; R2 and R3 are each (C,4) alkyl or, taken together with the nitrogen atom to which they are attached, form a saturated or unsaturated 5- to 10-membered heterocyclic radical optionally substituted one or more times by (C1-3) alkyl or (C1-3) alkoxy; each of R4, R5, R6, R7, R8 and R9 is independently hydrogen, halogen or trifluoromethyl, and when R1 is fluorine, R4, R5, R6, R7, R8 and/or R9 may also be fluoromethyl; with the proviso that at least one of substituents R4 or R7. is other than hydrogen; each of R10 and R11 is independently hydrogen or (C1-5) alkyl, or R10 and R11, taken together with the nitrogen atom to which they are attached, form a heterocyclic radical selected from pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or piperazin-1-yl optionally substituted by (C1-4) alkyl; a method for preparing same, and pharmaceutical compositions containing said compounds, are disclosed. Said compounds have very high affinity for central cannabinoid receptors.
Patent DE-69618767-T2 (DE)
Inventor: GLENN WAYNE
IPC: A61K8/92
Filed: 1996-02-20
Granted: 2002-12-05
Abstract: The present invention relates to a stress stable lathering skin cleansing liquid composition comprising by weight parts of the liquid composition:(a) from about 0.5 parts to 10 parts dispersed amorphous silica of synthetic origin, i.e., fumed or precipitated;(b) from about 5 parts to about 30 parts of lipid skin moisturizing agent having a Vaughan Solubility Parameter (VSP) of between 5 and 10; wherein said lipid has a shear index, n, value at 35° C. in the range 0.1 to 0.5 and a consistency, k, value at 35° C. in the range 10 to 3,000 poise;(c) from about 5 part to about 30 parts of surfactant;(d) water;wherein said surfactant has a combined CMC equilibrium surface tension value of from 15 to 50; and wherein said stress stable lathering skin cleansing liquid composition has a Lipid Deposition Value (LDV) of from about 5 to about 1000; also wherein said lathering cleansing liquid preferably has a shear index, n, value at 35° C. in the range 0.20-0.005 and a consistency, k, value at 35° C. preferably in the range 300-550 poise; and wherein said composition is stable for at least two weeks at 100° F. (38° C.).
Patent DE-69619577-T2 (DE)
Inventor: TIMMERMAN HENK
IPC: C07D211/70
Filed: 1996-04-19
Granted: 2002-07-18
Abstract: A piperidine derivative of formula (1) or salts thereof: <CHEM> wherein R<1> and R<2> independently represent H or together represent O, R<3> represents H, -R<5>-COOR<6>, or -COOR<6> (wherein R<5> is a lower alkylene group, -CONH-, or -CONHCH2, and R<6> is H or a lower alkyl group), R<4> represents H, an aralkyloxy carbonyl group, an aminomethyl carbonyl group, or an aralkyloxy carbonyl aminomethyl carbonyl group, A represents O or a double bond, and the broken line has the meaning that a bonding hand may be present; and preventive and therapeutic agents for allergies, antihistaminic agents, and antileucotriene agents comprising the derivative or salts as their effective component. The compound of formula (1) has excellent antihistaminic activities and antileukotriene activities, which are well balanced, and is useful as a drug for the prevention and treatment of allergies such as asthma, allergic rhinitis, allergic dermatosis and urticaria.
Patent DE-69621604-T2 (DE)
Inventor: VAN DER LINDEN KLAUS
IPC: A61M11/00
Filed: 1996-03-14
Granted: 2002-11-28
Abstract: PCT No. PCT/EP96/01092 Sec. 371 Date Sep. 10, 1997 Sec. 102(e) Date Sep. 10, 1997 PCT Filed Mar. 14, 1996 PCT Pub. No. WO96/28205 PCT Pub. Date Sep. 19, 1996The invention relates to an ultrasonic atomizer device (2) for a fluid (60), in particular a bronchospasmolytic agent, in which a propelling element (10) operable by an electronic circuit (6) to deliver the fluid to an atomization surface (28) that is also supplied with ultrasound waves from the electronic circuit (6) is provided in a housing (4), the propelling element (10) having a coupling member (32) which is meshing with a further coupling member (34) of a replaceable dosating unit (14) for transferring propelling power to the dosating unit (14) to effect a linear movement (68) of a piston (66) arranged in an ampoule (28) within the dosating unit (14). The invention also relates to a system comprising a device (2) as described and a dosating unit (14) inserted into that device (2).
Patent DE-69631176-T2 (DE)
Inventor: ENGELAERE JEAN-CLAUDE
IPC: B65D77/20
Filed: 1996-11-28
Granted: 2004-09-30
Abstract: A sealing assembly (S) for a container (C) with an opening including a sheet (F) welded to the edge of the opening and consisting of at least three layers. The layers comprise a weld layer (1) applied and welded to the edge of the opening along a bead (3), an outer barrier layer (2) and an intermediate adhesive layer (3). The weld between the bead (4) of the weld layer (1) and the edge of the opening has a tear resistance higher than the adhesive force between the weld layer (1) and the adhesive layer. After opening for the first time, the weld bead (4) remains in place along the edge and is separated from the weld layer (1) and the adhesive layer (3) which is thus exposed in an area (7) and enables the container (C) to be resealed by reapplying the layer onto the bead (4). Also claimed are: (i) a container equipped with the claimed sealing assembly; and (ii) a process for the manufacture of the claimed sealing assembly comprising welding the sheet (F) to the edge of the opening along a bead (4).
Patent DE-69633212-T2 (DE)
Inventor: BARD ALLEN J
IPC: G01N37/00
Filed: 1996-02-09
Granted: 2005-09-22
Abstract: Biomolecule analysis using anodic oxidation of aqueous sodium 9,10-diphenylanthracene-2-sulfonate (DPAS) and 1- and 2-thianthrenecarboxylic acid (1-THCOOH and 2-THCOOH) in the presence of tri-n-propylamine (TPrA) as a coreactant in aqueous solution produces electrogenerated chemiluminescence (ECL). In addition, the cathodic reduction of DPAS in the presence of peroxydisulfate (S2O82-) as a coreactant also produces ECL in an acetonitrile (MeCN)-water solution (1:1 by volume). The oxidation of chlorpromazine (CPZ) produces an ECL emission in the absence of an added coreactant following an unprecedented "self-annihilation" mechanism.
Patent DE-69711682-T2 (DE)
Inventor: JONES HENRY
IPC: G01S11/16
Filed: 1997-12-04
Granted: 2002-11-14
Abstract: A system for determining the position of each of a plurality of objects in a specified environment by determining the transit times of slowly propagating measurement energy transmitted from a measurement energy transmitter on each object to a plurality of fixed measurement energy receivers in the specified environment, the transmission of the measurement energy being triggered by a burst of high speed propagating trigger energy into the specified environment from a trigger energy transmitter, the measurement energy transmitter on each object being triggered by an object-mounted trigger energy receiver, each burst of trigger energy being encoded so as to trigger one only of the measurement energy transmitters, wherein a coordinating control system determines the order in which the measurement energy transmitters are triggered, in response to updatable information relating to service demands of the trigger energy transmitter and/or objects.
Patent DE-69715655-T2 (DE)
Inventor: HOSKING MICHAEL
IPC: B65H3/06
Filed: 1997-10-14
Granted: 2003-02-20
Abstract: Sheet feed apparatus for supplying sheets such as banknotes from a store (1) to a sheet transport system. The apparatus comprises a feed system (4) for withdrawing sheets from the store (1). A separator system (12) is provided to which sheets are fed by the feed system (1), the separator system being adapted to feed sheets singly to the sheet transport system (22, 23). A controller (29) controls operation of the feed and separator systems (1, 12) independently.
Patent DE-69717271-T2 (DE)
Inventor: XIE E
IPC: G01N27/48
Filed: 1997-05-30
Granted: 2003-07-03
Abstract: A polarographic sensor device to determine the partial pressure of a gas in a sample medium is disclosed. The device comprises a) a substantially hydroscopic electrolyte composition joining a pair of spaced apart electrodes, one of the pair of electrodes being a sensing electrode; b) a membrane permeable to gas but impermeable to the electrolyte, the membrane having a front section for separating the electrodes and the electrolyte from the sample medium; and c) a fastener comprising a sleeve having a body portion and a lip, the body portion retaining the fastener and a side section of the membrane, and the lip retaining a portion of the front section of the membrane and holding substantially the entire front section in a spaced apart relationship from the sensing electrode.
Patent DE-69727234-T2 (DE)
Inventor: WANG LIXIAO
IPC: A61L29/00
Filed: 1997-07-11
Granted: 2004-11-11
Abstract: Balloon especially useful for dilatation of gastrointestinal lesions has a burst pressure of at least 9 atmospheres, a diameter at 3 atmospheres of about 5 mm or more, and an average compliance over the range of from 3 atmospheres to burst of at least 3 % per atmosphere. Such balloons and balloons having other combinations of burst strength, compliance and diameter may be prepared by a method wherein a tubing of a thermoplastic polymer material is radially expanded under a first elevated pressure at an elevated temperature to form the balloon at a first diameter and then annealing the balloon at a second elevated temperature and a second pressure less than the first elevated pressure for a time sufficient to shrink the formed balloon to a second diameter less than the first diameter. The thermoplastic polymer material may be a block copolymer material. Catheters bearing balloons prepared by this method have low withdrawal force requirements, especially catheters used in through-the-scope applications.
Patent DE-69728380-T2 (DE)
Inventor: CLEARY P
IPC: A61K38/48
Filed: 1997-01-21
Granted: 2005-01-27
Abstract: Novel vaccines for use against beta-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of streptococcal C5a peptidase, or a fragment or mutant thereof. Also disclosed is a method of protecting a susceptible mammal against beta-hemolytic Streptococcus colonization or infection by administering such a vaccine.
Patent DE-69736074-T2 (DE)
Inventor: POWAR L
IPC: G06Q20/10
Filed: 1997-12-12
Granted: 2006-12-07
Abstract: The present invention consists of a secure interactive electronic account statement delivery system suitable for use over open networks such as the Internet. The invention utilizes a certification hierarchy to insure that electronic bills, invoices, and other account statements can be securely sent over open networks. The participants in the system are a certification authority, certificated banks, billers, and customers. The certification authority grants digital certificates to the certificated banks, which in turn grant digital certificates to billers and customers. Digital certificates form the basis for encryption and authentication of network communications, using public and private keys. The certificates associate a customer and biller with a certificated bank and with the electronic billing system, much like payment cards associate a customer with a payment card issuer and a particular payment card system. Digital signatures are used for authentication and non-repudiation. The certificates may be stored as digital data on storage media of a customer's or biller's computer system, or may be contained in integrated circuit or chip cards physically issued to billers and customers. The electronic bill itself may be a simple text message containing the equivalent of summary information for the bill, or may be more elaborate. In one embodiment of the invention, the electronic bill contains a number of embedded links, for example an embedded URL of a biller's world wide web server that allows the customer to interactively bring up detailed billing information by activating the link. The e-mail message may also include links to third party websites.
Patent DE-69802302-T2 (DE)
Inventor: KATZ MICHAEL
IPC: G06F3/02
Filed: 1998-09-30
Granted: 2002-07-11
Abstract: Prior miniaturzed palm-top computers have reduced-size keyboards which are not useful for standard typing. The present invention provides a folding pocket-sized computer, comprising up to a 12'' screen, a central processing unit, data storage and input means and a full size computer keyboard. It does this by having the keyboard divided into two halves hingedly connected along a fold line, whereby one of the keys is split along the fold line to permit folding of the keyboard, and by folding the screen and abutting the sections of the screen with no intervening frames.
Patent DE-69806413-T2 (DE)
Inventor: MAMBRETTI RICCARDO
IPC: B63B1/04
Filed: 1998-02-18
Granted: 2003-02-20
Abstract: A V-bottom for fast motor boats with longitudinal reaction walls reacting to a lateral trust from an air-water mixture which are substantially parallel and symmetrical in relation to keel is formed so that the reaction walls are the walls of flat-based grooves in a bottom joined to a flat base by a widely curving radius, or the reaction walls are the walls of ribs having a substantially trapezoidal cross-section and a flat horizontal lesser external base.</PTEXT>
Patent DE-69810409-T2 (DE)
Inventor: KUENEN HENDRIKUS ANTONIUS JACO
IPC: A23P1/08
Filed: 1998-09-01
Granted: 2003-09-25
Abstract: A device for coating food products with granular material, for example breadcrumb material, comprises a rotating conveyor belt which is permeable to the granular material and on which the food products can be held, guide plates which extend beneath at least a section of the top part and the bottom part of the conveyor belt, a feed, which opens out above the top part of the conveyor belt, for the granular material, diverter means for guiding the granular material from the top part to the bottom part of the conveyor belt and back, as well as conveyor means for conveying granular material from the top part of the conveyor belt to the feed. A divider plate to which granular material is fed from the top part of the conveyor belt is situated between the top part and the bottom part of the conveyor belt, via which divider plate the selected granular material is fed to the bottom part of the conveyor belt.
Patent DE-69810769-T2 (DE)
Inventor: PIIRAINEN OLLI
IPC: G06F13/10
Filed: 1998-05-12
Granted: 2003-09-25
Abstract: The invention relates to a method and arrangement for connecting a processor to an ASIC. In the arrangement, the processor generates control signals employed when the processor reads data from and writes data to the ASIC. The arrangement comprises means (10) for receiving control signals from the processor and generating read and write signals on the basis of the received signals. The means (10) are implemented by an asynchronous state machine that changes its state on the basis of the received signals. The means (10) change their state without a synchronizing clock signal.
Patent DE-69820888-T2 (DE)
Inventor: BARLOW ERIC
IPC: B05D3/10
Filed: 1998-10-13
Granted: 2004-12-09
Abstract: Coating comprising adhesion promoter(s) excluding silane is applied to an aluminium work piece with an anodic oxide film surface. Preferred Features: The work piece is an aluminium sheet, and has a paint, lacquer, varnish or enamel layer over the adhesion promoter layer.
Patent DE-69828038-T2 (DE)
Inventor: CHERIAN MATHEW
IPC: A61K47/48
Filed: 1998-01-28
Granted: 2005-11-03
Abstract: A pharmaceutical composition comprising a lipid complex or a liposome of a phospholipid and a water-insoluble platinum dicarboxylate and method for the preparation of such compositions are described.