Patent SG-11201809483U-A (SG)
Title: Production of steviol glycosides in recombinant hosts
Inventor: HANSEN IVER KLAVS RIISHEDE
IPC: C12P19/56
Filed: 2017-05-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/198681 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: strasse 56, 8049 Zurich (CH). OLSSON, Kim; Stenhug- C12P 19/44 (2006.01) Cl 2P 19/56 (2006.01) gervej 1, lth, DK-2400 Copenhagen (DK). (21) International Application Number: (74) Agent: REES, Kerry; WP Thompson, 138 Fetter Lane, PCT/EP2017/061774 London EC4A 1BT (GB). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 16 May 2017 (16.05.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (25) Filing Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (30) Priority Data: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 62/337,213 16 May 2016 (16.05.2016) US MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (71) Applicant: EVOLVA SA [CH/CH]; Duggingerstrasse 23, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, CH-4153 Reinach (CH). SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: HANSEN, Iver Klays Riishede; Graekenlans- vej 88B St., DK-2300 Copenhagen (DK). DOUCHIN, (84) Designated States (unless otherwise indicated, for every _ Veronique; Aurikelvej 2-4th, 2000 Frederiksberg (DK). kind of regional protection available): ARIPO (BW, GH, HOUGHTON-LARSEN, Jens; Groendalsvej 13, 3460 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Birkeroed (DK). HANSEN, Esben Halkjaer; Howitzvej UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 20B 2, DK-2000 Frederiksberg (DK). SEMMLER, An- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, gelika; Ernie Wilkins Vej 7, 1. Tv, Copenhagen SV EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = DK-2450 (DK). OCCHIPINTI, Laura; Brtmnwiesen- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = = Title: PRODUCTION OF STEVIOL GLYCOSIDES IN RECOMBINANT HOSTS (54) = Figure 3 = = XO HO = = 0 O 0 = HO O p H HO HO ON X OX = - = OH J It HOHO \"ONO Il GC V::+ cc c:r ,-1 it-- Steviol+6GIc (isomer 1) Steviol+7GIc (isomer 2) [Compound 6.1] [Compound 7.2] N (57) : The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosides of — steviol precursors, and steviol glycoside precursors. [Continued on next page] WO 2017/198681 Al MIDEDIM01101 DIVIROF11111111111111111111111011111111111111111111111111111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt amendments (Rule 48.2(h)) of — with sequence listing part of description (Rule 5.2(a))