Patent FR-2935096-A1 (FR)
Title: Composition of fruit extract of Rosaceae family seeds, useful to prepare e.g. food composition, comprises polyphenols, chlorogenic acid and combination of flavonols (quercetin), dihydrochalcone (phloridzin), and flavanols (catechins)
Inventor: SANOGO TIBOGO
IPC: A23L33/00
Filed: 2008-08-21
Abstract: Composition (I) of fruit extract of Rosaceae family seeds comprises: polyphenols (at least 25 wt.% related to the total weight of dried material of the composition); chlorogenic acid (at least 15 wt.%); and a combination of at least 15 wt.% of flavonols (quercetin), at least 10 wt.% of dihydrochalcone (phloridzin), and at least 10 wt.% flavanols (catechins). Independent claims are included for a process of preparing (I) comprising: either (a) contacting the starting material dissolved in a solvent on a suitable adsorbent resin of styrene-divinylbenzene, (b) eluting a first fraction rich in hydroxycinnamic acids with an aqueous solvent comprising 15-25 wt.% of ethanol, and recovering the first fraction and then obtaining a powder of the first fraction by removal of aqueous solvent, (c) eluting a second fraction rich in flavanols with aqueous solvent comprising 35-45 wt.% of ethanol, recovering the second fraction and then obtaining a powder of the second fraction by elimination of aqueous solvent, (d) eluting a third fraction rich in dihydrochalcones and flavanols with aqueous solvent comprising 60-80 wt.% of ethanol, and recovering the third fraction and then obtaining a powder of the third fraction by elimination of the aqueous solvent, and (e) preparation of (I) by mixing the obtained powders in appropriate proportions; or (aa) preparation of a fraction rich in hydroxycinnamic acid, comprising (a1) contacting a first material dissolved in a solvent and adjusting to an acidic pH on the adsorbent resin of styrene-divinylbenzene, and again adjusting to an acidic pH, where the acidic pH is 2-3, (a2) elution of first fraction rich in hydroxycinnamic acid with an aqueous solvent comprising ethanol (30-50%), recovering the first fraction, and obtaining a powder of first fraction by elimination of aqueous solvent, (bb) preparation of second fraction rich in flavonols and third fraction rich in flavonols and dihydrochalcones comprising (b1) contacting a first material dissolved in a solution in a appropriate solvent and adjusting to an basic pH on the adsorbent resin of styrene-divinylbenzene and again adjusting to an basic pH, where the basic pH is 6.5-7.5, (b2) elution of second fraction rich in flavonol with an aqueous solvent comprising ethanol (35-45 wt.%), recovering the second fraction, and obtaining a powder of second fraction by elimination of aqueous solvent, (b3) elution of a third fraction rich in flavonol and dihydrochalcones with an aqueous solvent comprising ethanol (65-75 wt.%), recovering the third fraction, and obtaining a powder of third fraction by elimination of aqueous solvent, and (cc) preparation of (I) by mixing the obtained powders in appropriate proportions. ACTIVITY : Nootropic; Dermatological; Osteopathic; Hypotensive; Anorectic; Antiarteriosclerotic; Anticoagulant. MECHANISM OF ACTION : None given.