baber/WOPTO huggingface dataset:
Patent CA-3097929-A1 (CA)
Title: Poxvirus host range protein k3 as a positive selection marker for generation of recombinant poxviruses, a therapeutic target for poxvirus infection and a therapeutic agent for pkr related diseases
Inventor: CAO JINGXIN
IPC: C12N7/00
Filed: 2019-03-22
Abstract: Described herein is a novel method for generation of recombinant poxviruses using an E3 and K3 double deletion mutant virus as the parental virus for generation of recombinant viruses. Following allowing for crossing over between the parental virus and an insertion cassette including an orthopox K3 peptide and the gene of interest, recombinant viruses are selected by infecting a host cell line permissive for the orthopox K3 peptide but not for the E3 and K3 double mutant parental virus. It is also demonstrated that a specific small molecule inhibitor of NEDD8 activating enzyme, MLN4924, can completely block poxvirus K3 family protein mediated PKR degradation and virus replication.
Patent CA-3102642-A1 (CA)
Title: Cleavable co-operative primers and method of amplifying nucleic acid sequences using same
Inventor: MAHONY JAMES BENSON
IPC: C12Q1/6853
Filed: 2019-06-07
Abstract: The present invention relates to an improved method for amplifying nucleic acid sequences using cleavable co-operative primers having a ribose base cleavage site, and a temperature stable polymerase enzyme.
Patent CA-3103870-A1 (CA)
Inventor: WIEGANDT FELIX
IPC: A61M11/00
Filed: 2019-07-02
Abstract: The present invention relates to a device (110) and a method for determining an aerosol delivery (210) of an aerosol stream (112), and a method for determining an absorption and/or adsorption of a liquid on aerosol particles (220). The device (110) comprises a collecting unit (116) having a filter (118) designated for collecting aerosol particles (120) carried by an aerosol stream (112), a first fluid connection point (122) which is connectable to an aerosol generator (114), and a second fluid connection point (124) which is connectable to a breathing simulator (126) being designated for simulating tidal breathing; at least one measurement volume (130) designed for an interaction of at least one light beam with the aerosol particles (120) carried by the aerosol stream (112) and passing through the measurement volume (130); at least one optical measurement unit (136) designed for generating at least one optical measurement signal depending on the interaction of the at least one light beam with the aerosol particles (120) passing the measurement volume (130); and at least one evaluation unit (140) designed for determining the aerosol delivery (210) of the aerosol stream (112) from the at least one optical measurement signal.
Patent CA-3104219-A1 (CA)
Title: Downhole flow control devices and methods
Inventor: ANDERSON JAMES
IPC: E21B34/08
Filed: 2019-06-19
Abstract: Described is a flow control device comprising a body locatable with a tubular and a flow regulator, housed within the body. The flow regulator defines a flow path through the body to accommodate flow between internal and external locations of a tubular in use. The flow regulator comprises a valve arrangement forming part of the flow path, and a biasing mechanism configured to urge the valve arrangement towards an open configuration from a restricted configuration in which fluid flow though the flow path is restricted. The biasing mechanism and the flow path through the flow control device are configured such that a differential pressure acting across the flow regulator, in excess of a particular threshold, moves the valve arrangement from the open configuration towards the restricted configuration in order to limit flow through the flow control device.
Patent CA-3108209-A1 (CA)
Inventor: LEE DAVID SCOTT
IPC: C12N15/82
Filed: 2021-02-04
Abstract: 18. Use of a soybean plant as defined in any one of claims 1, 3, 8, 10, 11, or for producing seed or growing a crop. 19. Use of seed of a soybean plant as defined in any one of claims 1, 3, 8, 10, 11, or 12 for producing a soybean plant. 20. Use of a soybean plant as defined in claim 1 for breeding with another soybean plant, as a recipient of a desired trait, or as a recipient of a single locus conversion.   Date Recue/Date Received 2021-02-04
Patent CA-3110006-A1 (CA)
Inventor: YANG YI
IPC: C07K16/28
Filed: 2019-09-11
Abstract: This disclosure provides an anti-TNFRSF9 (tumor necrosis factor receptor superfamily member 9) antibody, antigen-binding fragment, and the uses thereof.
Patent CA-3110590-A1 (CA)
Title: Bague d`etancheite et utilisation
Inventor: KOCH ANDREAS
IPC: F16J15/3212
Filed: 2021-02-26
Abstract: Il est décrit une bague détanchéité qui, une fois observée par coupe transversale, est construite sous la forme dun numéro 7, comprenant un premier élément axial (1) et un élément détanchéité (2) ayant une lèvre détanchéité (3), lélément détanchéité (2) étant raccordé à une première face plane (5) du premier élément axial (1) au moyen dun premier joint (4). Lélément détanchéité (2) a, sur le côté de ce dernier et orientée vers la première face plane (5), une lèvre anti-salissures (6) ayant au moins un bord étanche (7), ainsi quune première face de limite radialement interne (8) et une deuxième face de limite radialement externe (9).
Patent CA-3110745-A1 (CA)
Title: Cryoconservation de substrats ensemences par des cellules et procedes associes
Inventor: ARNOLD CASSIDY
IPC: A01N1/02
Filed: 2019-08-30
Abstract: L'invention concerne des procédés et des compositions d'identification de caractéristiques de cellules et de caractéristiques de substrats d'amélioration de viabilité, qui se rapportent à la survie post-cryoconservation de cellules ensemencées de substrats. Des modes de réalisation de la présente invention impliquent en outre l'identification de caractéristiques de cellules pour fabriquer un surnageant qui est utile pour la culture cellulaire et le traitement de diverses maladies.
Patent CA-3115076-A1 (CA)
Title: Augmented reality device with adjustable electroactive beam splitter
Inventor: VAN HEUGTEN ANTHONY
IPC: G02B26/02
Filed: 2019-10-08
Abstract: Bright ambient light can wash out a virtual image in a conventional augmented reality device. Fortunately, this problem can be prevented with a variable electro-active beam splitter whose reflect/transmit ratio can be varied or switched on and off rapidly at a duty cycle based on the ambient level. As the ambient light gets brighter, the beam splitter's transmit/reflect ratio can be shifted so that the beam splitter reflects more light from the display and transmits less ambient light to the user's eye. The beam splitter can also be switched between a highly reflective state and a highly transmissive state at a duty cycle selected so that the eye spends more time integrating reflected display light than integrating transmitted ambient light. The splitting ratio and/or duty cycle can be adjusted as the ambient light level changes to provide the optimum experience for the user.
Patent CA-3115180-A1 (CA)
Inventor: EIDSAA MARIUS
IPC: G16B20/30
Filed: 2019-10-04
Abstract: In a first aspect of the present disclosure, there is provided a computer-implemented method of predicting a binding affinity of a query binder molecule to a query target molecule, the query binder molecule having a first amino acid sequence and the query target molecule having a second amino acid sequence, the method comprising: computing, with the at least one processor, the binding affinity for the query binder molecule to the query target molecule as a weighted combination of reference binding values of reference binder-target subsequence pairs, wherein weights of the weighted combination are based on similarity scores.
Patent CA-3116625-A1 (CA)
Inventor: FRIELL JOSHUA CRAIG
IPC: A01B45/00
Filed: 2019-11-18
Abstract: An autonomous ground maintenance system comprising a vehicle 100 comprising a chassis supported upon a ground surface by ground support members 106, a container 110 supported by the chassis, the container defining a discharge outlet 111 operable to disperse treating material held within the container 110 to a target area of the ground surface, a gate 126 adapted to selectively open and close the discharge outlet, a sensor 128 adapted to identify the target area, and an electronic controller 120 supported by the chassis, the controller being in communication with the sensor and the gate, wherein the controller is adapted to position the chassis at a location proximate the target area such that the discharge outlet is capable of delivering the treating material to the target area and energize the gate to open the discharge outlet.
Patent CA-3117185-A1 (CA)
Title: Systems and methods for formatting and reconstructing raw data
Inventor: COTTEREAU GAETAN
IPC: G06F7/00
Filed: 2021-05-05
Abstract: A method for formatting raw data comprises accessing the raw data, the raw data comprising sparse data segments, which are empty of any data, and non-sparse data segments, which comprise data, and generating a formatted data stream comprising one or more atomic blocks, each atomic block corresponding to a metadata file and to a portion of the non-sparse data segments of the raw data. Generating one atomic block comprises browsing the raw data and, upon locating one sparse data segment, populating the corresponding metadata file with offsets indicative of a beginning and an end of the located sparse data segment and populating the atomic block with a concatenation of at least portions of the non-sparse segments of the raw data located before and after the located sparse segment. If the atomic block exceeds a maximum size, another atomic block and another corresponding metadata file are populated.
Patent CA-3117390-A1 (CA)
Inventor: FRANCHINI GENOVEFFA
IPC: C12N15/10
Filed: 2019-10-21
Abstract: L'invention concerne également des modes de réalisation de protéines gp120 du VIH-1 de recombinaison qui contiennent une délétion de V1. L'invention concerne également des protéines gp140, gp145 et gp160 contenant la délétion V1, ainsi que des trimères d'ectodomaine Env du VIH-1 contenant des protomères contenant la délétion V1. L'invention concerne également des molécules d'acide nucléique codant pour ces protéines. Dans plusieurs modes de réalisation, les protéines du VIH-1 de recombinaison et/ou les molécules d'acide nucléique peuvent être utilisées pour générer une réponse immunitaire contre le VIH-1 chez un sujet, par exemple, pour traiter ou prévenir une infection par le VIH-1 chez le sujet.
Patent CA-3117496-A1 (CA)
Inventor: CAMPBELL JEFFERY
IPC: B05B15/70
Filed: 2019-10-23
Abstract: A system for automated de-icing or contamination removal of an aircraft. The system includes a mobile platform, the mobile platform including a set of wheels and a swerve drive for controlling movement of the set of wheels along with a contamination removal apparatus mounted to the mobile platform for delivering contamination removal treatment to the aircraft. The system also includes a processor for receiving instructions associated with the contamination removal treatment from an external party and for controlling the mobile platform and contamination apparatus to deliver the contamination removal treatment.
Patent CA-3117886-A1 (CA)
Inventor: KORSUMAKI MIKA
IPC: B62M27/02
Filed: 2019-10-29
Abstract: A snowmobile has a frame, a tunnel, at least one ski operatively connected to the frame, a motor supported by the frame, and an endless drive track operatively connected to the motor. The tunnel extends above the endless drive track and has a first part and a second part. The second part extends rearward from the first part. The first part is made of a first material. The second part is made of a second material that is resilient. The second material is different from the first material. When a downward force is applied to a rear end of the second part, the second part bends downward from an original configuration such that the rear end of the second part moves toward the endless drive track. The second part returns at least approximately to its original configuration after removal of the downward force.
Patent CA-3118324-A1 (CA)
Inventor: HODGSON GRAEME
IPC: A61K31/675
Filed: 2019-11-01
Abstract: La présente invention concerne des procédés d'identification de patients souffrant de divers types de cancer qui sont plus susceptibles de réagir au traitement avec un inhibiteur de CDK7 conforme à la formule développée (I), (la), une espèce de celle-ci, ou une forme spécifiée de celle-ci (telle que décrite ici), soit lorsqu'elle est administrée ou utilisée seule ou en combinaison avec un second agent thérapeutique (par exemple, une autre thérapie anticancéreuse). Les patients sont identifiés sur la base d'une ou de plusieurs caractéristiques (par exemple, le nombre de copies ou le niveau d'expression de gènes) de certains biomarqueurs (par exemple, RB1 ou un autre élément de la voie biologique E2F). De plus, la présente invention concerne des méthodes de traitement d'un patient identifié avec un composé conforme à la formule développée (I), (la), une espèce de celui-ci, ou une forme spécifiée de celui-ci, soit seul, soit en combinaison avec un second agent thérapeutique. Dans un autre aspect, la présente invention concerne des kits comprenant des instructions pour traiter un patient identifié comme décrit ici.
Patent CA-3118886-A1 (CA)
Title: Cartridges for vaporizer devices
Inventor: ROSSER CHRISTOPHER JAMES
IPC: A24F40/00
Filed: 2019-11-05
Abstract: Cartridges (200) for vaporizer devices (100) are provided. In one exemplary embodiment, the cartridge (200) can include a reservoir housing (202) having a first housing end (206a) and a second housing end (206b) opposite the first housing end, an airflow tube (210) that extends through the reservoir housing, and first and second seals (214, 216) that are each substantially impermeable to fluid, in which the first seal is substantially secured to the first housing end and the second seal is substantially secured to the second housing end. The reservoir housing is configured to hold vaporizable material (204) and the first and second seals are configured to be selectively compromised to allow access to the vaporizable material within the reservoir housing for vaporization into vaporized material. Vaporizer devices are also provided.
Patent CA-3119079-A1 (CA)
Inventor: KIRCHMAIR MARTIN
IPC: E01H4/02
Filed: 2019-05-03
Abstract: A snow groomer vehicle includes a frame, a tool connected to the frame through a front connecting device equipped with an actuator assembly operable to determine a relative position of the tool with respect to the frame, a satellite navigation device and a control system. The control system includes a processing unit and a memory device, containing a target map representing a desired surface to be obtained by processing the snowpack over a region. The processing unit determines a position and orientation of the frame from the data provided with satellite navigation device and determines a configuration of the tool as a function of the position and orientation of the frame and of the target map, so that the passage of the tool causes a removal of the snowpack that conforms the snowpack to the target map. The actuator assembly is operated so as to bring the tool into the determined configuration.
Patent CA-3119233-A1 (CA)
Inventor: ADAM ALEX
IPC: B65G47/00
Filed: 2019-12-20
Abstract: The present invention concerns a device (1) for conveying products, which is intended for a production and processing line for these products and comprises at least one movable element in the form of a conveyor belt or link chain and a fixed support (2) for the movable element, the support being in the form of at least one slider (20), the slider (20) supporting the movable element in contact with at least one wear surface (4) located on said slider, characterised in that at least one slider (20) has, under the wear surface (4), at least one underlying layer (5), the underlying layer (5) consisting of a material with a different appearance to the appearance of the material of the wear surface (4). The invention further relates to a slider (20) for such a conveying device (1).
Patent CA-3120443-A1 (CA)
Title: Method and system for balancing mass flow during production failure or insufficiency in a district heating network
Inventor: HAMP QUIRIN
IPC: F24D10/00
Filed: 2019-11-21
Abstract: A method for balancing mass flow during production failure or insufficiency in a district heating network comprising a plurality of substations, each substation comprising at least one primary side connected to the district heating network for transferring heat between the district heating network and the substation, a secondary side connected to least one space heating circuit for heating at least one space connected to the substation, and an adjustable valve (102) arranged between the substation and the district heating network, the valve (102) in each substation being controlled by a heat curve f defining a calculated supply temperature (T supply, calc ) for the space heating circuit on the secondary side of the substation as a function of a measured outdoor temperature (Toutdoor). The method further comprises a step of heat curve compensation for each substation and population compensation for all substations in the population. The result is then used to control the valve (102) in the respective substation.
Patent CA-3121067-A1 (CA)
Title: Building construction system
Inventor: MARJABA GHASSAN
IPC: E04B1/18
Filed: 2021-06-04
Abstract: A construction system utilizes a post-and-beam structure that supports major gravity loads of a building in combination with prefabricated exterior and/or interior wall panels that are not required to support gravity loads beyond self-weight. Studs within the prefabricated wall panels are oriented such that a widest face thereof is other than normal to the wall surfaces attached thereto. Such an orientation of the wall studs reduces or eliminates thermal bridging in the structure without adding materials, thereby reducing embodied carbon and embodied energy content. The orientation of the wall studs also maximizes the available space within the wall panels to accommodate electrical and plumbing utilities and insulation material and utilizes the studs along their strong axis to resist lateral loads.
Patent CA-3123708-A1 (CA)
Inventor: SHIELDS MICHAEL
IPC: G06F17/00
Filed: 2021-07-05
Abstract: SynapseChain.com combines the data, structures, & assembly in one place. This is a step ahead of the current day website that requires so many servers repeating the same inefficient developer code. The current technology trends have been trapped in a primordial soup of ancient methodologies which assumed oil fuel, bio fuel, renewable energy and boiling water fuel (nuclear and geothermal) would be unlimited with carbon free to disseminate. However, once carbon tax becomes more of a responsibility, the outcome will result in cloud solutions in pursuit of drastic limits to its carbon privileges. Below shows the difference between current technology trends and the Synapse Chain Innovation.
Patent CA-3124706-A1 (CA)
Inventor: COSTON KYLE R
IPC: B61D17/08
Filed: 2020-01-22
Abstract: Selon certains modes de réalisation, l'invention concerne une extension de wagon pour étendre la largeur d'un wagon, l'extension comprenant : une partie supérieure destinée à être fixée à un support de wagon ; une première partie latérale couplée à la partie supérieure, la première partie latérale comprenant deux parois transversales parallèles reliées par une paroi longitudinale s'étendant toutes perpendiculairement à partir de la partie supérieure et les deux parois transversales étant destinées à être fixées au support de wagon ; une seconde partie latérale couplée à la première partie latérale, la seconde partie latérale comprenant deux parois transversales parallèles reliées par une paroi longitudinale s'étendant toutes vers le bas à partir de la première partie latérale et les deux parois transversales étant destinées à être fixées au support de wagon et la seconde partie latérale pivotant par rapport à la première partie latérale pour se conformer au support de wagon ; et une partie inférieure couplée à la seconde partie latérale, la partie inférieure étant destinée à être fixée au support de wagon.
Patent CA-3125927-A1 (CA)
Title: Pharmaceutical composition comprising antibody, device comprising same, and use thereof
Inventor: KIM MI-GYEONG
IPC: A61P19/02
Filed: 2020-01-13
Abstract: The present invention provides a liquid pharmaceutical composition with improved protein stability and, more specifically, a stable liquid pharmaceutical composition comprising an antibody, and use thereof.
Patent CA-3128284-A1 (CA)
Title: Method for introducing highly precompressed combustion air into a combustion chamber of an internal combustion engine, high-pressure inlet valve therefor and internal combustion engine having such a high-pressure inlet valve
Inventor: JUNKER ERWIN
IPC: F01L1/053
Filed: 2020-01-23
Abstract: A method for introducing combustion air into a cylinder (25) of an internal combustion engine, a high-pressure inlet valve (1) provided therefor and an internal combustion engine that operates using the method and the high-pressure inlet valve are described. All the combustion air for the respective cylinders (25) is introduced into the cylinder (25) of the internal combustion engine, by means of a high-pressure inlet valve (1) arranged in the relevant cylinder head (26) and on the basis of a controlled mass flow, such that mixture formation and charge exchange are intensified. In addition, the temperature and/or pressure of the combustion air is measured and the quantity of combustion air is introduced into the cylinder (25), in a controlled manner and on the basis of the measurement results, by means of the high-pressure inlet valve (1) by opening or closing a sliding piston (3) of the high-pressure inlet valve (1) by displacement. As a result of an axial displacement of the sliding piston (3) between guide sections (5) in the housing (2) of the high-pressure inlet valve (1), passage areas (6) for combustion air are blocked in a closed position (7) and opened in an open position (8). In the passage area (6), the sliding piston (3) has two pressurization areas (10, 11) facing each other, the surfaces of which are of equal size or differ from each other when projected in one plane. The first pressurization area (10) can be designed as a poppet valve (12) and the second pressurization area (11) can be designed as an annular surface (13). The internal combustion engine has a high-pressure line (27) for the combustion air, which line is connected to the high-pressure inlet valve (1). With respect to the longitudinal axis of the cylinder (25), the high-pressure inlet valve (1) is arranged in the cylinder head (26) in an upright or horizontal position.
Patent CA-3130577-A1 (CA)
Title: Josephson analog-to-digital converter system
Inventor: STOUTIMORE MICAH JOHN ATMAN
IPC: H03K19/195
Filed: 2020-02-04
Abstract: One example includes a Josephson analog-to-digital converter (ADC) system. The system includes a control line inductively coupled to an input signal line on which an input analog signal is provided. The input signal line can be inductively coupled to the control line to propagate an induced input current that is based on the input analog signal on the control line. The system also includes at least one Josephson transmission line (JTL) stage that is biased via a DC bias current and is configured to generate an output pulse in response to the induced input current and the DC bias current exceeding a predetermined threshold current associated with the at least one JTL stage.