baber/WOPTO huggingface dataset:
Patent DE-69208496-D1 (DE)
Inventor: SATO FUMIYASU
IPC: C07D217/06
Filed: 1992-03-30
Granted: 1996-04-04
Abstract: Succinic acid compounds of the formula: <CHEM> wherein A represents a heterocyclic group, a 3 to 8-membered cycloalkyl group or a phenyl group which may have one or more substituents selected from the group of a halogen atom, a lower alkyl group having 1 to 6 carbon atoms and a lower alkoxy group having 1 to 6 carbon atoms; B represents a bicyclic amino group which may have 1 or 2 unsaturated bonds, with the proviso that B bonds to the carbon atom of the carbonyl group at the nitrogen atom; R represents a hydrogen atom or combines each other to form a chemical bond; R<1> represents a hydrogen atom, a lower alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 10 carbon atoms; when there is an asymmetric carbon atom, enantiomers thereof and racemic mixtures thereof; when there are geometrical isomers, each geometrical isomer, E-isomers thereof, Z-isomers thereof, cis-isomers thereof and trans-isomers thereof; and pharmaceutically acceptable salts thereof, enhance insulin secretion and possess a hypoglycemic activity, and are thus useful for the treatment of diabetes.
Patent DE-69217727-D1 (DE)
Inventor: DAPPEN GLEN M
IPC: G01N33/543
Filed: 1992-06-04
Granted: 1997-04-10
Abstract: A dry immunoassay analytical element, comprising a coating containing an enzyme labeled ligand over a particulate layer containing a fixed concentration of immobilized receptor for a ligand is described. <IMAGE>
Patent DE-69219221-D1 (DE)
Inventor: LACOSTE JEAN-MICHEL
IPC: A61K31/28
Filed: 1992-07-02
Granted: 1997-05-28
Abstract: Compounds of formula (I):  (* CHEMICAL STRUCTURE *) (I) in which: R1 or R4, which are identical or different, represent hydrogen or alkyl, R2represents hydrogenm or alkyl, hydroxymethyl, -CH2OPO(OH)2 or -CH2OPO(ONa)2, R3 represents hydrogen, alkyl or hydroxyl or any one of the following groups:    (* CHEMICAL STRUCTURE *)   (* CHEMICAL STRUCTURE *)  in which: T represents oxygen or sulfur, n represents an integer between 1 and 4, R5 represents hydrogen or alkyl, X represents nitrogen, CH or CR'3 (in which R'3 has the same meaning as R3 except in the case where R3 represents hydroxyl), A represents alkylene of formula -(CH2)p-in which p represents an integer between 2 and 4, optionally substituted by one or more linear or branched (C1-C4) alkyl, or any one of the following radicals:  (* CHEMICAL STRUCTURE *)  Y and Z together form oxygen or simultaneously represent two hydroxyl and in this case, the compound of formula (I) is positively charged, their isomers as well as their addition salts with a pharmaceutically acceptable acid or base. Medicinal products.
Patent DE-69224157-D1 (DE)
Inventor: PARIKH AJAY
IPC: H03J7/16
Filed: 1992-11-13
Granted: 1998-02-26
Abstract: An autotuning combiner (16) particularly for use in combining signals for radio telephony transmission. The combiner has a series of filter cavities (18) each with an adjuster (22) for fine-tuning the cavity to an input carrier signal. The combiner cavities are stabilized from positional drift in the absence of a carrier signal by means of a mechanical brake (38, 44) which holds the adjuster or a pilot signal generator (70) which stimulates the absent carrier signal. <IMAGE>
Patent DE-69226343-D1 (DE)
Inventor: CICCONE JEAN-MICHEL
IPC: G06K19/077
Filed: 1992-12-15
Granted: 1998-08-27
Abstract: It relates to a medium (1) for information stored in an internal memory (4) linked to a connection region (6) printed on one (5, 9) of the faces of the medium (1). The memory (4) and its connection region (6) are integrated into a functional support element (3) fixed removably to the support (1). The double card may be used in a present-day standard receiver and can also be used in a future miniature receiver. It is well adapted to public phones and radio telephones. <IMAGE>
Patent DE-69229722-D1 (DE)
Inventor: HOEGER CARL
IPC: C07D239/42
Filed: 1992-03-11
Granted: 1999-09-09
Abstract: Peptides which include unnatural amino acids and which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. The peptides are analogs of the decapeptide GnRH wherein there is at least one residue of an unnatural amino acid U<*> in the 3-, 5- and/or 6-positions. Such unnatural amino acids are useful in the synthesis of peptides and can be formed after synthesis of the peptide chain. The unnatural amino acid U<*> can have a cyanoguanidino group on the omega carbon atom of the side chain, but preferably has formula U<*> (I) where j is 1 or 2 and R11 is H or an acyl radical having 1 to 6 carbon atoms.
Patent DE-69231828-D1 (DE)
Inventor: LE JUNMING
IPC: C07K7/08
Filed: 1992-03-18
Granted: 2001-06-21
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-± (TNF±) and are useful  in vivo  diagnosis and therapy of a number of TNP±-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Patent DE-69232153-D1 (DE)
Inventor: BHATNAGAR RAJENDRA S
IPC: C12N5/00
Filed: 1992-12-03
Granted: 2001-11-29
Abstract: Compositions of the invention include composites comprising a biomaterial carrying compounds with enhanced cell binding with respect to collagen. These composites are useful for soft and hard tissue repair or reconstruction. Suitable compounds with enhanced cell binding include synthetic peptides that mimic the conformation necessary for recognition and docketing of collagen binding species (such as cell surface receptors for collagen and fibronectin). Hydrogel matrices as the biomaterial promote cell attachment to the matrix and cell migration into the matrix.
Patent DE-69306744-D1 (DE)
Inventor: KAMESWARAN VENKATARAMAN
IPC: C07D405/04
Filed: 1993-10-08
Granted: 1997-01-30
Abstract: There is provided a method for the preparation of 2-aryl-5-trifluoromethyl pyrrole compounds which are useful as insecticidal, acaricidal and nematicidal agents and as intermediates in the manufacture of said agents.
Patent DE-69328341-D1 (DE)
Inventor: GUTTER BEZALEL
IPC: A61K39/395
Filed: 1993-12-01
Granted: 2000-05-18
Abstract: The invention relates to a vaccine for the prevention of Infectious Bursal Disease in poultry comprising an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92052301 (MB), an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92100106 (MB-2), or an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92102209 (MB-1). In addition, the invention relates to a method of preventing Infectious Bursal disease in poultry by administering to the birds an effective immunizing amount of the said vaccines. The invention relates to three novel virus strains deposited at the ECACC under No. V92052301 (MB), under No. V92100106 (MB-2) and under No. V92102209 (MB-1). Furthermore, the invention relates to a method of preparing live vaccines which protect poultry against Infectious Bursal Disease, containing an effective immunizing amount of a virus of the strain deposited at the ECACC under No. V92052301 (MB) and/or No. V92100106 (MB-2) and/or No. V92102209 (MB-1).
Patent DE-69329726-D1 (DE)
Inventor: LEVINE ROBERT A
IPC: G01N33/543
Filed: 1993-10-29
Granted: 2001-01-11
Abstract: A patient's health is diagnosed by centrifuging blood samples in a transparent tube, which tube contains one or more groups of particles such as lyposomes or plastic beads of different densities for each group. Each group of density-defined particles carries antigens or antibodies which are specific to a complement antigen or antibody which may be in the blood sample being tested, and which are indicative of the patient's health. A label-tagged antibody which is specific to all bound antibody/antigen couples is added to the blood sample so as to form labeled antibody+antigen-antibody complexes (AAAC) in the blood sample. Upon centrifugation, the complexed particles will settle out in different areas in the tube according to the respective density of the particles, and the degree of label emission of the particle layers can enable qualitative or quantitative analyses of the blood sample to be made. Unbound labeled antibodies will be washed away from the complexed layers by the washing action of the descending blood cells during the centrifugation step. Unbound labeled antibodies will thus not interfere with the analysis.
Patent DE-69332580-D1 (DE)
Inventor: OTA JUNZO
IPC: A61F13/02
Filed: 1993-10-15
Granted: 2003-01-30
Abstract: The bandage has release paper (3) over a pressure-sensitive adhesive layer (2) on plastic film (1), and a support (5) formed by two plastic film pieces butted (6) transversely and centrally of the length and fusion-bonded (7) to the film to be peelable from the abutment after applying the bandage. The substrate is pref. polyurethane film 10-100 microns thick and the support is polyethyleneterephthalate film 20-120 microns thick. Peel strength between support and substrate is pref. 10-100 g per 25 mm width and there is a release strip (8) over the butt joint with a peel strength w.r.t. the support of 15-150 g per 25 mm width.
Patent DE-69401734-D1 (DE)
Inventor: LOUWERSE GERARD MARIE
IPC: B65D17/44
Filed: 1994-10-14
Granted: 1997-03-27
Abstract: Full-aperture easy-open metal can-end for a can of the lift-up type with a tab, having an endless score-line (3) close to its outer circumference of the can-end, wherein the removable part is profiled with a plurality of terraces (5, 6, 7) at different heights, including an outer terrace (5) close to the outer circumference of the can-end, an innermost terrace (7) and at least one intermediate terrace (6). Adjacent terraces merge into one another with a height transition. To achieve low tear-force and/or other advantages, the intermediate terrace (6) is inclined in a direction opposite to that of the outwardly adjoining transition at an angle  alpha  in the range 3 to 20 degrees to a plane perpendicular to the can axis. <IMAGE>
Patent DE-69409510-D1 (DE)
Inventor: KRABSEN ERIK
IPC: A23C3/00
Filed: 1994-05-11
Granted: 1998-05-14
Abstract: PCT No. PCT/DK94/00190 Sec. 371 Date Feb. 28, 1996 Sec. 102(e) Date Feb. 28, 1996 PCT Filed May 11, 1994 PCT Pub. No. WO94/26121 PCT Pub. Date Nov. 24, 1994A plant and a method of treating milk so as to obtain milk with a low content of spores and bacteria. In a centrifugation unit (4) the milk is separated into a cream fraction (CR) and a skim-milk fraction. The skim-milk fraction is separated in a microfiltration unit (8) into a spore and bacteria-containing retentate (R) and a permeate (P) with a low content of spores and bacteria. The cream fraction (CR) is sterilized in a sterilizing unit (16), and the sterilized cream (STCR) or a portion thereof is mixed with the permeate (P) into standardized milk. The retentate is recirculated to the centrifugation unit (4) which is of the type separating the material into the cream fraction (CR), the skim-milk fraction (SM), and furthermore a sludge fraction (SL). The plant and the method ensure a high microfiltration capacity and the cheese formation properties of the milk is maintained.
Patent DE-69410442-D1 (DE)
Inventor: SLAUGH LYNN
IPC: B01J31/24
Filed: 1994-02-03
Granted: 1998-06-25
Abstract: This invention relates to a process for making 1,3-diols and 3-hydroxyaldehydes by hydroformylating 1,2-epoxides which process comprises intimately contacting (a) a 1,2-epoxide having more than 2 carbon atoms, (b) ditertiary phosphine-modified cobalt carbonyl catalyst, said phosphine comprising a hydrocarbylene-bis(monophosphabicyclo-alkane) in which each phosphorus atom is joined to hydrocarbylene and is a member of a bridge linkage without being a bridgehead atom and which hydrocarbylene-bis(monophosphabicycloalkane) has 11 to 300 carbon atoms; of which 5 to 12 carbon atoms together with a phosphorus atom are members of each of the two bicyclic skeletal structures, (c) carbon monoxide, and (d) hydrogen, the molar ratio of carbon monoxide to hydrogen being from 4:1 to 1:6, preferably from 1:1 to 1:4 in liquid-phase solution in an inert reaction solvent, at a temperature of from 30 to 150  DEG C and a pressure of from 345 to 68948 kPa (50 to 10,000 psi).
Patent DE-69410744-D1 (DE)
Inventor: WHITLOCK MICHAEL B
IPC: B01D29/00
Filed: 1994-09-09
Granted: 1998-07-09
Abstract: A method of making a filter assembly consists of seating a filter pack (20) in opposing end caps (10, 11) and applying a mixt. (25) to said filter pack (20) and end caps (10, 11). Said mixt. comprises a binder containing a low temperature component, e.g., a nickel based alloy, and a high temperature component comprises a metal particulate, e.g., stainless steel, or ceramic material, e.g., silicon carbide. After application, the mixt. is degassed under vacuum to eliminate air bubbles, and agitated, e.g., by vibration, to ensure penetration into the filter pack. The end caps (10, 11) and filter pack (20) are then permanently bonded by firing in a furnace, wherein the binder is driven off and the low melt component fills the interstices between the high temp. particles, and also fills the pores in the filter pack and flows along the end caps.
Patent DE-69417929-D1 (DE)
Inventor: WASASTJERNA JAN
IPC: F24F3/12
Filed: 1994-11-04
Granted: 1999-05-20
Abstract: PCT No. PCT/FI94/00498 Sec. 371 Date May 13, 1996 Sec. 102(e) Date May 13, 1996 PCT Filed Nov. 4, 1994 PCT Pub. No. WO95/13044 PCT Pub. Date May 18, 1995The invention relates to a method for regulating the atmosphere in a substantially closed sports/exercise space (1) or an animal shelter (11), especially in terms of partial oxygen pressure. In the method, the normal atmosphere of said space (1; 11) is admixed with nitrogen for the creation of a desired low-oxygen (oxygen content <appr. 21%) atmosphere, said low-oxygen atmosphere corresponding to partial oxygen pressure in the air at a certain altitude above sea level. Alternatively, said normal atmosphere is admixed with oxygen for the creation of a desired high-oxygen (oxygen content>appr. 21%) atmosphere. Said mixing of nitrogen or oxygen with air is carried out at normal air pressure.
Patent DE-69422501-D1 (DE)
Inventor: STERN J
IPC: A61K35/74
Filed: 1994-03-16
Granted: 2000-02-10
Abstract: A preparation effective for reducing colonization by human enteropathogenic bacteria in poultry is prepared from cultures of mucosa-associated flora obtained from ceca of mature birds and is referred to as mucosal competitive exclusion (MCE). The preparation is especially effective for both Salmonella and Campylobacter spp. Administration of the novel MCE preparation to newly-hatched or hatching birds provides substantial protection against both microorganisms and results in the diminished presence of both in processed poultry products.
Patent DE-69425161-D1 (DE)
Inventor: DORN P
IPC: C07D413/14
Filed: 1994-12-13
Granted: 2000-08-10
Abstract: Substituted heterocycles of general structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: R<1> is selected from the group consisting of: hydrogen; C1-6 alkyl, unsubstituted or substituted; C2-6 alkenyl, unsubstituted or substituted; C2-6 alkynyl; phenyl, unsubstitued or substituted; X is selected from the group consisting of: -O-, -S-, -SO-, -SO2-; Y is selected from the group consisting of: a single bond, -O-, -S-, -CO-, -CH2, -CHR5- and -CR<15>R<16>; Z = C1-6 alkyl, are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
Patent DE-69426127-D1 (DE)
Inventor: MCCARTHY DAVID F
IPC: B65D19/00
Filed: 1994-04-20
Granted: 2000-11-16
Abstract: This patent discloses an improved lightweight, recyclable, nearly completely paper pallet. The pallet is made of a Honeycomb paper base and Honeycomb paper support runners or blocks. The blocks are protected and significantly strengthened by a rigid paper cap. The base, runners, blocks, and cap may also have a protective liner, such as polyethylene, or be otherwise treated to enhance water and moisture resistance.
Patent DE-69433802-D1 (DE)
Inventor: COSSEMENT ERIC
IPC: A61P43/00
Filed: 1994-03-09
Granted: 2004-06-24
Abstract: The use of levorotatory or dextrorotatory enantiomers of 1-(4-chlorophenyl)phenylmethylpiperazine derivatives (V) or their salts in medicines for the treatment of allergies, is new.  The use of levorotatory or dextrorotatory enantiomers of 1-(4-chlorophenyl)phenylmethylpiperazine derivatives of formula (V) or their salts, in medicines for the treatment of allergies, is new:  R  =  H, (3-methylphenyl)methyl, (4-tert-butylphenyl)methyl, 2-(2-hydroxyethoxy)ethyl, 2-(2-(hydroxyethoxy)ethoxy)ethyl, 2-(carbamoylethoxy)ethyl, 2-(methoxycarbonylmethoxy)ethyl or 2-(carboxymethoxy)ethyl.
Patent DE-69434402-D1 (DE)
Inventor: LA HAYE PETER G
IPC: B29D11/00
Filed: 1994-12-07
Granted: 2005-07-14
Abstract: Self-stick or press-on magnifying or corrective optical lenses or optical elements (10, 20, 30) which are injection-molded from an aliphatic thermoplastic polyurethane may be securely but releasably secured by their inherent molecular surface-adhesion characteristics to the surface of a sunglass or plano lens (12, 22, 32) by finger pressure alone to readily provide a magnifying or corrective lens suitable for incorporation into the frame of a normal pair of sunglasses or plano eyeglasses (14, 24).
Patent DE-69504195-D1 (DE)
Inventor: KEMP ERIC
IPC: E05B73/00
Filed: 1995-06-13
Granted: 1998-09-24
Abstract: A security system and device for safeguarding a computer or peripheral (10) from theft and removal of internal components such as the CPU comprises an enclosure (13) and a per se known securing assembly (11) for securing the enclosure (13) to the structure; the enclosure (13) comprising a plurality of members (14, 15, 17, 18) adjustably secured together to conform to and encircle at least three adjacent sides of the article (10) and secured together by fastener means accessible solely from within the enclosure (13); the enclosure (13) further comprising one or more end members adapted to be secured to conform to the article (10) at one or both ends orthogonal to said three adjacent sides; the enclosure (13) or the article (10) subsequently being secured to the structure by the per se known securing assembly (11).
Patent DE-69506261-D1 (DE)
Inventor: VATELOT YVES
IPC: B65D1/02
Filed: 1995-08-09
Granted: 1999-01-07
Abstract: Bottle (1) with external anti-return lock means and a deformable pleated outer lateral wall (4). The outer anti-return lock means (2) cooperates with peripheral shoulders (8) projecting outwardly from the bottle, from the outermost folding lines (7) of the pleated wall, to hold the bottle in one of a series of inner volume states, enabling the bottle to gradually change its shape from a given volume state to a further reduced volume state, so that the inner volume of the bottle can be adapted to the liquid remaining therein. The invention is especially suitable for fizzy liquids.
Patent DE-69508434-D1 (DE)
Inventor: HARRISON TIMOTHY
IPC: A61P29/00
Filed: 1995-12-15
Granted: 1999-04-22
Abstract: PCT No. PCT/GB95/02927 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 15, 1995 PCT Pub. No. WO96/20197 PCT Pub. Date Jul. 4, 1996The present invention relates to spiroketal derivatives of formula (I) and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R9a, R9b, m and n are as defined in the specification, and to processes for their preparation, to intermediates used in their synthesis, to pharmaceutical compositions containing them, and to their use in therapy. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.    <IMAGE>  (I)
Patent DE-69515451-D1 (DE)
Inventor: GRANDVEAU GILLES
IPC: F24C15/18
Filed: 1995-12-27
Granted: 2000-04-13
Abstract: The gas cooker has a hob with an aperture (6) to receive a cooking vessel (7). Beneath the vessel there is, at least, one gas burner (8) supported by a holder (10) between the cooker housing (15) and the underside (14) of the vessel. The holder is fitted to the rim (11) of the aperture. The vessel rests on that same rim. A gap (17) for the combustion gases is formed between the edges of the vessel (9) and holder (18). Optionally, the gap can be linked to a chamber beneath the upper surface (4) of the hob to form a re-heating zone. The holder and housing can have inlets (23,24) for air to assist the combustion. A porthole (31) in the hob allows the flame from the burner to be observed.
Patent DE-69515459-D1 (DE)
Inventor: MUNCH GAUTE
IPC: H03K17/955
Filed: 1995-01-18
Granted: 2000-04-13
Abstract: A capacitive sensor comprises capacitance sensing means 1 and oscillator means 2, for measuring capacitive changes. The oscillator means 2 comprises a unity gain buffer 3 for buffering the voltage over the capacitance sensing means 1 without imposing any load on the latter, the output terminal of the unity gain buffer 3 being connected to the input terminal of charging means 4 for charging and discharging the capacitance sensing means 1 via a resistor 5 which is connected to the capacitance sensing means 1 and to the output of the charging means 4. Guard means 7 arranged to at least partially surround the capacitance sensing means 1 and connected to the output of the unity gain buffer 3 can be provided to shield the capacitance sensing means 1 from capacitive changes caused by interferential action. <IMAGE>
Patent DE-69524623-D1 (DE)
Inventor: RATTI EMILIANGELO
IPC: A61K38/05
Filed: 1995-10-12
Granted: 2002-01-24
Abstract: The use of CCK-B antagonists for the treatment of sleep disorders.
Patent DE-69528890-D1 (DE)
Inventor: BARRITAULT DENIS
IPC: A61P25/28
Filed: 1995-03-29
Granted: 2003-01-02
Abstract: The use of at least one polymer or biopolymer known as HBGFPP, capable of specifically protecting growth factors of families FGF and beta-TGF from trypsin damage, for preparing a drug for treating nervous system damage, is disclosed.
Patent DE-69535104-D1 (DE)
Inventor: KADDURAH-DAOUK RIMA
IPC: A61K31/195
Filed: 1995-11-07
Granted: 2006-08-17
Abstract: The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer disease, Parkinson's disease, stroke, Huntington's disease, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases. The Creatine compounds which can be used in the present method include: (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine; (3) creatine analogs which can act as reversible or irreversible inhibitors of creatine kinase, and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.