baber/WOPTO huggingface dataset:
Patent JP-2002179097-A (JP)
Title: Pouch having hanging means
Inventor: MATSUDA NAOHITO
IPC: B65D33/14
Filed: 2000-12-20
Abstract: PROBLEM TO BE SOLVED: To provide a pouch having a hanging means wherein distributing suitability of pouches filled with contents can be improved without causing an increase in cost, while the rigidity and stability of form of a heat sealed part forming an engaging part being a hanging means of the pouch are not injured, and when in use, a user can easily form the engaging part being the hanging means of the pouch using his fingers. SOLUTION: In the pouch formed by heat-sealing a plastic film, a weakened part is provided in a heat-sealed part of the pouch, and a break starting part is provided at or near the weakened part to break the weakened part from the starting part, whereby the engaging part for hanging is formed.
Patent JP-2002187058-A (JP)
Title: Method for removing minute foreign matters and rolling bearing
Inventor: YAJIMA HIROTAKA
IPC: B24B31/02
Filed: 2000-12-20
Abstract: PROBLEM TO BE SOLVED: To securely remove minute foreign matters remained in manufacture of parts for a bearing. SOLUTION: A process 4 for removing the minute foreign matters remained is provided before a precision water cleaning process 5 to remove the foreign matters remained, such as metal powder of materials and damaged and dropped pieces of components for bearing parts, produced during a cutting process 1, a heat treatment process 2 and a grinding process 3 in manufacturing processes of each component parts for a rolling bearing. In the process 4 for removing the minute foreign matters remained, damage to surfaces of parts for the rolling bearing which are caused by removing operations of such foreign matters remained can be restrained to a lower level by using crashed materials made of raw materials of an ear core of maize as grinding media. Such media is easily adaptable to the surfaces of the parts for the bearing and the minute foreign matters can be effectively removed.
Patent JP-2002188583-A (JP)
Title: Scroll compressor
Inventor: KAWABATA NATSUKI
IPC: F04C18/02
Filed: 2000-12-21
Abstract: PROBLEM TO BE SOLVED: To provide a scroll compressor capable of operating with high reliability for a long time by preventing the corrosion due to hammering minute vibration. SOLUTION: This scroll compressor has a turning scroll 2, two fixed scrolls 3, 4, crank shafts 5, 6 driving the turning scroll 2, and a slide mechanism absorbing relative positional fluctuation between the crank shafts of the turning scroll 2 and the fixed scrolls 3, 4. The slide mechanism is provided with a sleeve 12 having a plane in which a bearing is inserted and on which outer periphery is parallel with the direction connecting the main crank shaft 5 and the auxiliary crank shaft 6 and sliders 14A, 14B arranged at outer periphery of the sleeve so as to slide in contact with the plane of the sleeve 12. Either of slide faces on which these sleeve 12 and sliders 14A, 14B slide is formed by resin.
Patent JP-2001169422-A (JP)
Title: Coupling metal tool used in the prefabricated come- alongless method and metal tools using the same coupling metal tool
Inventor: KATO SUSUMU
IPC: H02G1/02
Filed: 2000-12-22
Abstract: PROBLEM TO BE SOLVED: To provide a coupling metal tool wherein a tensile adjusting tool is not in contact with a vernier metal tool. SOLUTION: One end is provided with a crevice type fitting area for coupling a compression type retaining clamp for compressing a transmission line, while the other end is provided with an eye type fitting area for coupling an come- alongless metal tool or a wire connector. Moreover, a tool fitting area is also provided at the intermediate part of such fitting areas. This tool fitting area is provided with a semi-metal wheel fitting hole to fit a semi-metal wheel at the time of extension where hole direction becomes parallel to the fitting direction of the crevice fitting area and also with an extension degree adjusting tool fitting hole where the hole direction is orthogonal to the semi-metal wheel fitting hole direction.
Patent JP-2002192475-A (JP)
Title: Fastening tool
Inventor: OSHITA MASATO
IPC: B23P19/06
Filed: 2000-12-22
Abstract: PROBLEM TO BE SOLVED: To reduce the assembling cost by shortening the working time of a bolt fastening work. SOLUTION: The tip of a rotary shaft 34 is made into a tapered face 51 having an angle θ1 relative to a face orthogonally crossing with the rotary shaft 34 (axis C2) and a face in the side of a slide piece 33 in contact with the tapered face 51 is formed into a slope face 37 having an angle θ2 relative to the face orthogonally crossing with the axis C1 of a socket 31 so that in the initial state before fitted in the bolt 11, the socket 31 is bent in the angle θ1+θ2 relative to the rotary shaft 34.
Patent JP-2002195569-A (JP)
Title: Cooker
Inventor: GOBI AKIRA
IPC: F23N5/20
Filed: 2000-12-25
Abstract: PROBLEM TO BE SOLVED: To solve the problem that when a drip pan is used for mounting and carrying a material to be heated into/from a heating chamber to cook it with/without water for a cooking time as described in a cooking book, a fish may be too or half baked, the heated material or a fat component emerging from the heated material may be fired to flame out through exhaust holes of a cooker. SOLUTION: A heating chamber 1 has temperature sensors 6, 8 at the bottom 5 of a drip pan 4 and the wall or an exhaust hole 7 of the heating chamber 1 to discriminate the existence of water in the pan 4 or a light load, based on temperature outputs of the sensors, and the time from the cooking start and the cutoff of the gas and the gas cutoff temperature are set to avoid firing a heated material or a fat component of the heated material, and the gas quantity is set by a gas adjuster to eliminate the cooking time variation, irrespective of the existence of water in the drip pan.
Patent JP-2002192471-A (JP)
Title: Grinding tool
Inventor: TOMITA YASUHISA
IPC: B24D3/00
Filed: 2000-12-25
Abstract: PROBLEM TO BE SOLVED: To provide a grinding tool capable of surely cooling a grinding part related to a grinding tool formed by fixing super abrasive grains on the outer circumferential part in the tip end face of a body part. SOLUTION: This grinding tool is characterized in having the columnar body part 11 rotating about a central shaft 13, the super abrasive grains 15 fixed to the outer circumferential part in the tip end face of the body part, a plurality of recess parts 11f formed in the outer circumferential part in the tip end face, and through holes 11h having one end opening formed inside the recess part 11f in the tip end face and the other opening formed in a position except for the tip face of the body part 11.
Patent JP-2002194170-A (JP)
Title: Low birefringence resin composition
Inventor: YAMASHITA YUKIHIKO
IPC: G02B1/04
Filed: 2000-12-26
Abstract: PROBLEM TO BE SOLVED: To provide a resin composition having an excellent heat resistance, a low moisture absorbance, a low dielectric constant and a superior optical characteristic. SOLUTION: This low birefringence resin composition is obtained by blending (A) a cyclic polyolefin resin having a carboxyl group and/or a phenolic hydroxyl group and (B) a styrenic resin having an alkylamino group and/or a pyridyl group in the range of a weight ratio (A)/(B) of 20/80-95/5.
Patent JP-2002197321-A (JP)
Title: Mail-order system
Inventor: USHIDA SHINICHI
IPC: G06Q10/00
Filed: 2000-12-26
Abstract: PROBLEM TO BE SOLVED: To provide a mail-order system capable of quickly and accurately delivering products and minimizing damage by an unpaid account. SOLUTION: This mail-order system is provided with a host computer 1 having an order receiving means 21, a delivery means 22, a billing means 23, an input means 4 and an output means 5. The order receiving means 21 can perform an order receiving waiting process 21a, a certification process 21b, a crediting process 21c, an advertising process 21d, a catalog determining process 21e, a product input process 21f, a quantity confirming process 21g, and an order receipt confirmation process 21f. Since order receiving can be processed according to user's ability in payment, the unpaid account is prevented to be a large amount. Also, order receiving can be stopped quickly even if unpayment happens to prevent unpaid amount from being a large amount. It is also prevented that a user cannot pay a bill because of a large amount.
Patent JP-2002198102-A (JP)
Title: Manufacturing method of square-type battery
Inventor: INAGAKI MINORU
IPC: H01M10/05
Filed: 2000-12-26
Abstract: PROBLEM TO BE SOLVED: To provide a preparation method of a square-type battery, wherein short circuiting between a positive electrode and a negative electrode of the battery is avoided and a voltage reduction will not be caused during storage of the battery by improving the manufacturing process of the electrode group. SOLUTION: A spiral electrode group 1 is formed by winding a sheet-formed positive electrode, a separator and a sheet-formed negative electrode around a flat bobbin; after the bobbin is pulled out, a thin plate 3 is inserted into a central gap part 2 of the electrode group instead of the bobbin; the thin plate 3 is abutted on the inner peripheral folding part of the electrode group at both ends of the longitudinal direction of the central gap part; then the electrode group is smashed by pressurizing from a direction orthogonal to the thin plate; and the electrode group molded is inserted in this way into a case of the square- type battery.
Patent JP-2002061430-A (JP)
Title: Vehicle door equipped with antitheft structure
Inventor: JANG SAM-SEOK
IPC: E05B83/36
Filed: 2000-12-26
Abstract: PROBLEM TO BE SOLVED: To provide a vehicle door equipped with an antitheft structure incapable of operating a lock assembly of a locking device even if a tool is inserted from a gap between a door glass and an outside handle site and unlocking a locking device for the door without having any exclusive key for a vehicle. SOLUTION: The vehicle door equipped with the antitheft structure is constituted of an actuator operating the locking device by a switch at an operator' s seat and the lock assembly consisting of a load assembly connected h out/ inside handles operated at the outside and inside of the vehicle and a fixed bracket fixing to a run-channel of the door while connecting a lock lever for operating an operating section making an unlocking action to a locking by connecting through the assembly, a slider formed in the shape of a circular arc to the upper site of the lock lever is integrally formed in the lock lever, and the fixed bracket includes the antitheft structure integrally formed of a cut off plate projecting one side end of the lock lever so as to make it possible to shield it.
Patent JP-2002198515-A (JP)
Title: Manufacturing method of chip semiconductor element
Inventor: ISHIHARA KENJI
IPC: H01L29/74
Filed: 2000-12-27
Abstract: PROBLEM TO BE SOLVED: To propose a manufacturing method of a chip semiconductor element wherein thermal-stress buffering plates can be bonded to the semiconductor element at a low temperature without generating reduction of its breakdown voltage, and the reliability of the bonding force of an alloy plate made of Al and Si to a Mo plate used as each thermal-stress buffering plate can be improved too. SOLUTION: IN the manufacturing method, firstly, there are formed a main electrode 12 and a gate electrode 11 by the depositions of Al on one side of a semiconductor element main body 10 formed out of a plurality of N-layers and P-layers whose corner portions are coated with passivation films 15. Next, there is formed a main electrode 13 by the deposition of Al on the other side of the main body 10. Thereafter, to both main electrodes 12, 13, via respective alloy plates 1, 2 made of Al and Si, and via respective Al layers 50, 51 which are formed by depositing Al on the respective one-sides of the thermal-stress buffering plates 30, 31 made of Mo, in the reduction atmosphere of the temperature range of 580-630 deg.C, the thermal-stress buffering plates 30, 31 are bonded.
Patent JP-2002195155-A (JP)
Title: Single-head swash plate compressor
Inventor: MATSUMURA YOSHITO
IPC: F04B27/08
Filed: 2000-12-27
Abstract: PROBLEM TO BE SOLVED: To provide a single-head swash plate compressor, in which abrasion of an annular sliding and contacting surface of the swash plate with a shoe, which floats from the swash plate and partially contact on the swash plate, is suppressed. SOLUTION: This single-head switch plate compressor comprises: a driving shaft; a swash plate attached to the driving shaft and rotating in synchronization with the driving shaft; a single-head piston head to the swash plate through a pair of shoes slidably clamping the swash plate; and a cylinder block having a bore into which the single-head piston is slidably inserted. A metal plate having hardness larger than the swash plate is pressed-in on the annular sliding and contacting surface of the swash plate with the shoe.
Patent JP-2002154987-A (JP)
Title: Method for producing body fat metabolic decomposition promoter
Inventor: YOKOYAMA TSUNETAKA
IPC: A23L33/00
Filed: 2000-11-21
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a body fat metabolic decomposition promoter providing a remarkable effect on promotion of body fat metabolic decomposition, widely applicable not only to the human body but also in the field of meat in food processing, etc., by formulating β3-adrenaline receptor agonist (β3-agonist) with a protein lipase and saponin-containing Japanese and Chinese medicines. SOLUTION: This method for producing a body fat metabolic decomposition promoter comprises formulating β3-adrenaline receptor agonist (β3-agonist) with a protein lipase, Japanese and Chinese medicines, Panax notoginseng, (saponin-containing) Platycodon grandiflorum, vitamins, a dietary fiber and peptide.
Patent JP-2002203095-A (JP)
Title: Method and system for marketing, and information recording medium
Inventor: HANAKADA TETSUO
IPC: G06Q10/00
Filed: 2000-12-28
Abstract: PROBLEM TO BE SOLVED: To provide a marketing method and system capable of increasing access to a website and also improving efficiency of marketing, and an information recording medium. SOLUTION: In the method, the marketing is performed with a server for providing a service by using a user's terminal by a computer and network. There is provided a step for reading the information to be read of a providing medium having readable information to be read with the user terminal. Furthermore, there are provided a step for converting the information to be read into identification information of a file being managed with the server, and a step for accessing the file of the server corresponding to the converted identification information by the user terminal.
Patent JP-2002201246-A (JP)
Title: Method for producing rigid plastic foam
Inventor: OTA TAKAMICHI
IPC: C08G18/00
Filed: 2000-12-28
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a rigid polyurethane foam or a urethane-modified rigid polyisocyanurate foam whereby a normal foam can be obtained even under conditions in which the atmospheric temperature during foam production is low in the case in which HCFC-141b is used as a blowing agent. SOLUTION: There is provided a method for producing a rigid polyurethane foam or a rigid urethane-modified polyisocyanurate foam, which process comprises reacting an active-hydrogen-containing compound with a polyisocyanate compound in the presence of a low-boiling halohydrocarbon blowing agent, wherein the blowing agent used is a mixture of 0.1-30 wt.% HFC-125 and/or HFC-143a with 99.9-70 wt.% HCFC-141b.
Patent JP-2002178669-A (JP)
Title: One check reply
Inventor: SHIBATA MASAMI
IPC: B42D15/02
Filed: 2000-12-14
Abstract: PROBLEM TO BE SOLVED: To solve the problem that a receiver customer of a direct mail thinks it very troublesome to entry his address, name and the like in a reply form when the mail is delivered and also bothers to call up for the reply, and on the other hand, a sender has to obtain information on the address, name and the like from the receiver customer so that the customer is identified. SOLUTION: This invention to solve the described conventional problem is characterized in that a few number of itemized replies to be expected from the receiver customer are previously printed on the address side of the direct mail.
Patent JP-2002192870-A (JP)
Title: Clip
Inventor: HIRAIWA KAZUMI
IPC: B42F1/02
Filed: 2000-12-26
Abstract: PROBLEM TO BE SOLVED: To remarkably increase the number of possible charging in a binder of a clip held by clipping a sheet or the like. SOLUTION: The clip comprises a plate-like member having elasticity and bent in an isosceles triangular shape as seen from a side to form upper and lower elastic force urging parts 12 and 14 extended corresponding to oblique sides from a bottom 16 corresponding to a bottom side. The clip can insert a sheet or the like from the end 18 side at an opposite side to the bottom 16. The parts 12 and 14 have cutouts 12a and 14a cut out from the end 18 side at a center in a width direction. The bottom 16 is at a center out from both lateral sides. The with A of the bottom 16 is smaller than a width B of the cutouts 12a and 14a.
Patent JP-2001512069-A (JP)
Title: 自動車の乗客保護手段の制御用に設けられた回路装置のテスト用の装置及び方法
IPC: B60R21/00
Filed: 1998-07-17
Abstract: (57)【要約】
自動車の乗客保護手段の制御用回路装置は、テスト電流（Ｉ ＬＡＤＥ ）を供給するエネルギ源（５）により給電される、エネルギ蓄積コンデンサ（１）と、点弧エレメント（２）と制御可能な電力段（３）との直列回路との並列回路を有している。エネルギ蓄積コンデンサ（１）が少なくともかなりの量（ｗｅｉｔｇｅｈｅｎｄ；ｌａｒｇｅ  ｅｘｔｅｎｔ）放電されていて、前記電力段（３）が検査の目的で導電接続されている場合、直列回路（２，３）内で降下している検査電圧（Ｕ ＰＲＵＥＦ ）が検出されて評価される。
Patent JP-2001512102-A (JP)
Title: 超求核性４−置換−ピリジン触媒、及びその調製に有用な方法
IPC: B01J31/02
Filed: 1998-07-31
Abstract: (57)【要約】
押出し成型粒状化超求核性４−アミノ置換ピリジン触媒を製造する好ましい方法、及びそれから得られる粒状産物につき記載する。又、活性化でのアクリル酸若しくはアクリルアミド又はその類似体の使用、及び温和な塩基性条件下で、４−置換の為に過剰のアミン試薬中で行なわれる置換工程を含む、４−アミノピリジン化合物を製造する為の好ましい活性化−置換−脱活性化法についても記載する。前記方法は、純粋な熱安定性な形態の産物を回収する為に、更に容易に処理される、改良された反応物を提供する。更に、４−置換ピリジンをピリジンベタイン経由で調製する方法について記載する。
Patent JP-2001512300-A (JP)
Title: 少なくとも１つの固定アクセサリを取り付けたワイヤケーブルラックおよび固定アクセサリ
IPC: H02G3/04
Filed: 1998-06-26
Abstract: (57)【要約】
本発明は、少なくとも１つの固定アクセサリ（１８）を局部的に取り付けて、電気ケーブル（１６）を支持しかつ固定するワイヤケーブルラック（１０）に関する。固定アクセサリ（１８）は、ワイヤケーブルラック（１０）と一体化させるための固定手段（２０、２１）と、固定アクセサリ（１８）を貫通し、クランプフィッティング（１７）、ボルト等の任意の固定要素を受け入れることができる少なくとも１つの孔（２２、２３）とを有している。
Patent JP-2001514110-A (JP)
Title: 車両における情報指示方法
IPC: G08G1/0967
Filed: 1998-08-20
Abstract: (57)【要約】
車両における情報指示方法が提案され、その際指示ユニットに、カメラの画像の部分が指示され、それは制御および評価ユニットによる評価後、１つの道路標識を含んでいる。
Patent JP-2001517781-A (JP)
Title: 液流測定装置
IPC: G01F23/14
Filed: 1998-09-23
Abstract: (57)【要約】
内側に室空間（13）を有する筐体（12）、該筐体の上部にあって液体を室空間（13）に送る導入管（８）、前記筐体の底部に設けられ室空間（13）から液体を送出する排出管（11）、室空間（13）に配置されて有堰容器を形成する要素（１，２）、および室空間（13）で液体の高さを測定する手段（３）を有し、前記要素が壁（２）と該壁に形成された少なくとも１つのオリフィス（１）とを有し、該オリフィス（１）を経て液体が前記排出管（11）へと送出されるようになっている液体量を測定する装置。この装置は、導入管（８）を経て室に入る液体を少なくとも２つの副流（14、15）に分け、これらの副流を異なる方向から壁に設けられたオリフィス（１）近傍の一点に集める手段（10）を有し、副流（14、15）が再び合流するときに、それらが実質的に流勢を弱めるようにしている。
Patent JP-2002525500-A (JP)
IPC: F16B23/00
Filed: 1998-10-28
Abstract: A spiral drive system for threaded fasteners includes driver-engageable surfaces on the head end of the fastener in which at least some of the driver-engageable surfaces are defined by a spiral segment configured to maximize torque transmission while spreading the driving load over a broad driver-fastener interface to reduce the risk of development of high stress regions. Drivers and related tooling also are disclosed.
Patent JP-2001525428-A (JP)
IPC: C08L101/00
Filed: 1998-12-04
Abstract: Waterborne polyurethanes possessing urea-urethane linkages that are not separated by any intervening carbon atoms may be obtained by using hydroxylamine as a chain extender. Isocyanate-terminated prepolymer possessing ionized or easily ionizable groups is reacted with NH2OH to form a polyurethane possessing urea-urethane linkages corresponding to the formula: The waterborne polyurethanes are useful in adhesive, coating and ink formulations and in the flexible package industry.
Patent JP-2001525642-A (JP)
Title: ショートメッセージ伝送システムおよびその方法
IPC: H04W8/26
Filed: 1998-12-01
Abstract: (57)【要約】
本発明は、仮想加入者番号に対してショートメッセージを伝送するシステムに関する。また、本発明は、加入者専用のＶＰＮ（仮想的な専用ネットワーク、ＶＰＮ、バーチャル  プライベート  ネットワーク）加入者番号に対してショートメッセージを伝送するシステムに関する。さらに、本発明は、仮想加入者番号に対してショートメッセージを伝送する方法に関する。本発明は、加入者専用のＶＰＮ加入者番号に対してショートメッセージを伝送する方法にも関する。
Patent JP-2003526382-A (JP)
Title: 自己組合せ型接着ファスナー要素、自己組合せ型接着ファスナー要素を有する物品、並びに製造および使用方法
IPC: A44B18/00
Filed: 1998-04-20
Abstract: (57)【要約】
自己組合せ型接着ファスナー要素（１０）が記載されている。自己組合せ型接着ファスナー要素（１０）は、各々が基部と延長部と非粘着性先端とを有する複数の支柱（１４）を備える。支柱（１４）は、自己組合せパターンとファスナー選択性とを提供するように配列される。接着剤層（１６）は、第１の表面と第２の表面とを有するように設けられる。第１の表面は、支柱の間に粘着性表面を提供する。第２の表面（２２）は、自己組合せ型接着ファスナーを支持体に接着する。自己組合せ型接着ファスナー要素を組み込む物品、自己組合せ型接着ファスナー要素を製造する方法およびこれを使用する方法がさらに開示される。
Patent JP-2002501843-A (JP)
IPC: B29C45/14
Filed: 1999-01-29
Abstract: A method for making a stopper. The method includes the step of providing a first tool defining a first tool cavity and a second tool defining a second molding cavity. A first plug member having an upper surface and a lower surface also is provided, the upper surface of the first plug member having a concave portion. The first plug member is faced in the first cavity such that at least a portion of the lower surface of the first plug member is in contact with the first cavity. The second tool defines a hole therethrough such that the hold provides fluid contact between the second tool cavity and a point exterior to the second tool. A polymeric material is transferred through the hole defined by the second tool into the second cavity defined by the second tool and into the concave portion of the upper surface of the first plug member such that the polymeric material forms a second plug member having an upper surface and a lower surface, the upper surface of the second plug member being defined by the molding surface defined by the second tool. The first plug member and the second plug member define a stopper. The stopper is then removed form the first and second tools.
Patent JP-2002507509-A (JP)
Title: フィンガグリップ器具付きの筆記用具
IPC: B29C45/00
Filed: 1999-03-26
Abstract: (57)【要約】
筆記用具（10）は、筆記媒体を担持したカートリッジ（12）及びその一端に露出した状態で設けられた筆記先端部（14）を有している。カートリッジ（12）は、環状に凹んでいてテーパした空所（15）を形成する減少断面部を有している。グリップ部材（16）が、空所（15）に嵌まっており、このグリップ部材は、形状が管状であってカートリッジ（12）のテーパした輪郭をたどるようテーパしている。グリップ部材（16）は、僅かに隆起したパターン（20）を備える滑らかな表面（18）を有している。隆起パターン（20）は、連続格子模様を形成するよう配置された複数の互いに連結された部分から成る。隆起パターン（20）は、滑らかな表面（18）に対して弾性的に圧縮可能であり、ユーザの指が隆起パターン（20）を変形させて使用中における引っ掛かりが別途生じる。筆記用具は、通気孔付きキャップ（24）を更に有している。
Patent JP-2002509922-A (JP)
Title: ４，４−二置換−３，４−ジヒドロ−２（１ｈ）−キナゾリンチオン誘導体、それらの調製法、およびｈｉｖ逆転写酵素阻害剤としてのそれらの使用
IPC: C07D409/06
Filed: 1999-03-23
Abstract: (57)【要約】
本発明は、ＨＩＶ逆転写酵素阻害剤として有用な式（Ｉ）の４，４−二置換−３，４−ジヒドロ−２（１Ｈ）−キナゾリンチオンであって、Ｒ 1 は１〜７個のハロゲンで置換されたＣ 1   〜   3 アルキルであり、Ｒ 2 は１〜２個のＲ 4 で置換されたＣ 1   〜   5 アルキル、１〜２個のＲ 4 で置換されたＣ 2   〜   5 アルケニル、および１個のＲ 4 で置換されたＣ 2   〜   5 アルキニルから選択され、Ｒ 4 は０〜２個のＲ 3 で置換されたＣ 3   〜   5 シクロアルキル、０〜５個のＲ 3 で置換されたフェニル、ならびに０〜２個のＲ 3 で置換され、Ｏ、Ｎ、およびＳから選択された１〜３個のヘテロ原子を含む５〜６員環の複素環系から選択される化合物と、式（ＩＩ）の化合物であって、Ｒ 2 はＣ≡Ｃ−Ｒ 4a であり、Ｒ 4a はメチル、エチル、ｎ−プロピル、ｉ−プロピル、ｉ−ブチル、ｔ−ブチル、およびｉ−ペンチルから選択され、Ｒ 3 は、それぞれの出現時に、Ｃ 1   〜   4 アルキル、ＯＨ、Ｃ 1   〜   4 アルコキシ、Ｆ、Ｃｌ、Ｂｒ、Ｉ、ＮＲ 5 Ｒ 5a 、ＮＯ 2 、ＣＮ、Ｃ（Ｏ）Ｒ 6 、ＮＨＣ（Ｏ）Ｒ 7 、およびＮＨＣ（Ｏ）ＮＲ 5 Ｒ 5a から独立に選択され、あるいは、２個のＲ 3 が存在して、隣接する炭素に結合している場合、それらは組み合わされて−ＯＣＨ 2 Ｏ−を形成してもよく、Ｒ 8 はＨ、Ｃ 3   〜   5 シクロアルキル、およびＣ 1   〜   3 アルキルから選択され、かつｎは０、１、２、３、および４から選択される化合物、またはそれらの立体異性体、立体異性体の混合物、もしくは薬剤に許容可能な塩の形に関し、同物質を含む医薬品組成物および診断キット、ならびにウイルス感染症を治療するため、またはアッセイ標準物質もしくは試薬として同物質を用いる方法に関する。
【化２８】
 【化２９】
Patent JP-2002510686-A (JP)
Title: アミノアルキルで置換された５，６，７，８−テトラヒドロ−９Ｈ−ピリジノ［２，３−ｂ］インドール及び５，６，７，８−テトラヒドロ−９Ｈピリミジノ［４，５−Ｂ］インドール誘導体：ＣＲＦ１特異的配位子
IPC: A61P1/00
Filed: 1999-04-01
Abstract: (57)【要約】
【化１】
 上記一般式Ｉの化合物（式中、Ａｒ、Ｒ １ 、Ｗ、Ｘ及びｍは、明細書に定義される通りの置換基である。）が、開示されている。これらの化合物は、ＣＲＦレセプターの調整剤であり、それ故に、感情疾患、不安、鬱病、頭痛、過敏性腸症候群、外傷後ストレス疾患、核上麻痺、免疫抑制、アルツハイマー病、胃腸疾患、神経性食用不振症又は他の栄養障害、薬物嗜癖、薬物又はアルコール使用中止症候群、炎症性疾患、心臓血管又は心臓に関連する疾患、妊孕性問題、ヒト免疫不全ウイルス感染、出血ストレス、肥満症、不育症、頭部及び脊髄外傷、てんかん、発作、潰瘍、筋萎縮性側索硬化症、低血糖症、又は疾患の治療であって、その治療は、哺乳類における、ＣＲＦによって誘発されるか又は助長される疾患を含むが、それに限定されるものではなく、ＣＲＦに拮抗することによってもたらされるか、又は、助長され得り、一般式Ｉの化合物を、治療に効果的な量、哺乳類に投与することからなる治療に有用である。