Patent SG-11201804312R-A (SG)
Title: Microbubble-chemotherapeutic agent complex for sonodynamic therapy
Inventor: CALLAN JOHN
IPC: A61P35/00
Filed: 2016-11-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau ristspi id (43) International Publication Date .... ....r .„,„1 1 June 2017 (01.06.2017) WIPO I PCT ID Hit (10) 1111111111111111111 WO International Publication Number Ell 2017/089800 1111111111111111011111111111111111111 Al In (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 41/00 (2006.01) A61P 35/00 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 47/69 (2017.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/GB2016/053682 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 23 November 2016 (23.11.2016) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 1520649.3 23 November 2015 (23.11.2015) GB (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: UNIVERSITY OF ULSTER [GB/GB]; Room GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 26A20, Office of Innovation Jordanstown Campus, Shore TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Road, Newtownabbey Northern Ireland BT37 OQB (GB). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: CALLAN, John; c/o University of Ulster, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Room 26A20, Office of Innovation, Jordanstown Campus, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Shore Road Newtownabbey Northern Ireland BT37 OQB SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (GB). MCHALE, Anthony; c/o University of Ulster, GW, KM, ML, MR, NE, SN, TD, TG). Room 26A20, Office of Innovation, Jordanstown Campus, Published: Shore Road Newtownabbey Northern Ireland BT37 OQB 21(3)) — with international search report (Art (GB). STRIDE, Eleanor; c/o University of Oxford, Insti- tute of Biomedical Engineering, Old Road Campus Re- — with sequence listing part of description (Rule 5.2(a)) search Building, Oxford Oxfordshire OX3 7DQ (GB). (74) Agent: DEHNS; St Bride's House, 10 Salisbury Square, London London EC4Y 8JD Greater (GB). 1-1 .4t C::: , C::: , GC Cr \ GC C::: , IN 1-1 (54) Title: MICROBUBBLE-CHEMOTHERAPEUTIC AGENT COMPLEX FOR SONODYNAMIC THERAPY 0 N (57) : The invention relates to methods of sonodynamic therapy comprising the co-administration of a microbubble-chemo - ega ) therapeutic agent complex together with a microbubble-sonosensitiser complex. It further relates to pharmaceutical compositions comprising these complexes and their use in methods of sonodynamic therapy and/or sonodynamic diagnosis. Such methods find particular use in the treatment of cancer, e.g. pancreatic cancer.