baber/WOPTO huggingface dataset:
Patent IT-MI952331-A1 (IT)
Title: Film multistrato estensibili
Inventor: PERDOMI GIANNI
IPC: C08L23/16
Filed: 1995-11-14
Abstract: FILM MULTISTRATO ESTENSIBILI IN CUI ALMENO UNO STRATO (A) DI ESSI COMPRENDE UN COPOLIMERO (I) DELL'ETILENE CON UNA O PIU' A-OLEFINE CH2=CHR, AVENTE UNA DENSITA' COMPRESA TRA 0,88 E 0, 945 G/CM3, UN MELT INDEX DA 0,1 A 10 G/10' E CONTENENTE FINO AL 20% IN MOLI DI A-OLEFINA CH2=CHR (LLDPE), E ALMENO UNO STRATO (B) COMPRENDE UNA COMPOSIZIONE POLIOLEFINICA ETEROFASICA AVENTE:(A) 20-100 PARTI IN PESO DI UNA FRAZIONE INSOLUBILE IN XILENE A TEMPERATURA AMBIENTE COMPRENDENTE UN OMOPOLIMERO DEL PROPILENE O UN COPOLIMERO DEL PROPILENE CON ETILENE E/O UN'ALTRA A-OLEFINA CH2=CHR I, CONTENENTE PIU' DEL 85% IN PESO DI UNITA' DERIVANTI DAL PROPILENE; E,(B) 30-80 PARTI DI UNA FRAZIONE SOLUBILE IN XILENE A TEMPERATURA AMBIENTE COMPRENDENTE UN COPOLIMERO AMORFO DELL'ETILENE CON PROPILENE E/O UN'ALTRA A-OLEFINA CH2=CHR I, EVENTUALMENTE CONTENENTE PROPORZIONI MINORI DI UN DIENE, CONTENENTE PIU' DEL 15% IN PESO DI UNITA' DERIVANTI DALL'ETILENE.
Patent IT-MI962077-A1 (IT)
Inventor: STABILE ALDO
IPC: F24C7/04
Filed: 1996-10-08
Abstract: Electric radiating tube (30) for generating and diffusing heat obtained with spirally wound bands (20-23), entirely or partially superimposed, one or more of said bands (20, 22) being of electrically insulating material and one or more of said bands (21, 23) being of highly conducting material, thickness being measured in microns with an extremely high ratio between area and thickness, and of a constant cross section, there being at the ends of said tube (30) means of connection and contact (32, 43, 44) for electric feed, said means being connected to one or more of the highly conducting bands (21, 23).
Patent IT-MI971268-A1 (IT)
Inventor: DESANTIS NICOLA
IPC: C07C229/62
Filed: 1997-05-30
Abstract: A process for the preparation of 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide of formula (I), starting from 5-amino-1,3-benzenedicarboxylic acid of formula (II), comprising the following steps: step a) is the reaction in heterogeneous phase between 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid and thionyl chloride in a solvent selected from the group consisting of: straight or branched (C7-C16) hydrocarbons, (C7-C8) aromatic hydrocarbons, 1,1,1-trichloroethane, n-butyl acetate, diglyme (diethylene glycol dimethyl ether), in the presence of catalytic amounts of a tertiary amine, to give compound (III); step b) is the acetylation reaction of compound (III) with glacial acetic acid both as the solvent and the reagent and thionyl chloride; step c) is the formation of compound (V) by reaction of the compound (IV) with 1-amino-2,3-propanediol, by reaction of compound (IV) in a dipolar aprotic solvent, selected from the group of dimethylformamide (DMF), dimethylacetamide (DMA), dimethylsulfoxide (DMSO) or N-methyl-pyrrolidinone; step d) is the alkylation of the compound (V) in aqueous solution at basic pH, by addition of a sodium hydroxide-calcium hydroxide mixture, with 3-chloro-1,2-propanediol or epichlorohydrin, at a temperature of 40-90 DEG  C.
Patent IT-MI991120-A1 (IT)
Inventor: CABRI WALTER
IPC: C07D501/14
Filed: 1999-05-21
Abstract: A process for the preparation of Cefuroxime acid (1), which comprises the following steps: (1) Extraction of deacetyl 7-glutaryl ACA (II) aqueous solution at acid pH with organic solvents (for example according to the procedures disclosed in U.S. Pat. No. 5,801,241); (2) drying the resulting solution while preventing lactonization of the intermediate; (3) carbamoylation of the hydroxymethyl group at the 3-position by reaction with chlorosulfonyl isocyanate or similar products; (7) extraction of the carbamoyl derivative from step 3 with water at neutral pH; (8) enzymatic hydrolysis of the amide at the 7-position of the cephalosporanic ring with glutaryl acylase; (6) acylation of the amino group by condensation with 2-furanyl(sin-methoxyimino)acetic acid chloride or mixed anhydride.
Patent IT-PD950064-A1 (IT)
Title: Asciugatore personale per l'intero corpo
Inventor: MICHIELIN LORENO
Filed: 1995-03-27
Abstract: Si tratta di un asciugatore costituito da un corpo tubiforme a sviluppo verticale alto quanto una persona, dotato di fori o fessure per tutta la sua altezza nonché di una elettroventola, di una serie di termoresistenze elettriche e di comandi; l'elettroventola insuffla aria attraverso le termoresistenze all'interno del corpo tubiforme; l'aria riscaldata esce attraverso le fessure o i fori asciugando completamente ed interamente la persona che sta davanti all'asciugatore.
Patent IT-PE910018-A1 (IT)
Title: Dispositivo per il recupero della pallina da gioco in gomma.
Inventor: PALMERINI ORIELLA
Filed: 1991-09-25
Abstract: L'invenzione in oggetto si prefigge lo scopo di rientrare in possesso facilmente della pallina da gioco in gomma.Lo scopo viene raggiunto collegando la pallina stessa ad una zavorra, capace anche di galleggiare, mediante un elastico di idonea resistenza. L'elastico viene ancorato alla pallina mediante un ago a forma di forcella azionato da un pistone pneumatico.
Patent IT-PR940032-A1 (IT)
Title: Procedimento di riconoscimento e registrazione di informazioni, e  apparato che realizza il procedimento, in particolare per applicazione
Inventor: MICHELOTTI VITTORIO
IPC: G06K/
Filed: 1994-08-09
Abstract: Il trovato si inserisce nel campo dei procedimenti ed impianti di acquisizione e riconoscimento di informazioni da oggetti e più precisamente si riferisce ad un procedimento e ad un apparato di particolare applicazione in campo agricolo, in cui la fase di acquisizione e riconoscimento delle informazioni avviene movimentando almeno un apparato acquisitore - riconoscitore (6, 9) rispetto agli oggetti (5).Ciascun apparato acquisitore - riconoscitore (6, 9) è infatti applicato ad un relativo mezzo semovente (1) in modo tale che l'acquisizione delle informazioni avvenga durante il movimento di ciascun apparato (6, 9) rispetto agli oggetti (5).
Patent IT-TO940132-A1 (IT)
Title: Valvola di sfiato e di sicurezza in caso di ribaltamento per serbatoi  di veicoli
Inventor: LOBASCIO OSVALDO
IPC: B60K15/035
Filed: 1994-02-28
Abstract: La valvola comprende un corpo fisso (10) ed un corpo mobile (12). Il corpo fisso (10) presenta superiormente una sede conica di valvola (20) che comunica con un bocchettone (22) di raccordo ad una tubazione di sfiato. Il corpo mobile (12) presenta un risalto conico superiore (32) atto a cooperare con la sede di valvola (20) a guisa di spillo otturatore. Entrambi i corpi fisso (10) e mobile (12) sono in forma di campana aperta all'estremità corrispondente all'interno del serbatoio. Il corpo mobile (12) è imprigionato nel corpo fisso (10) tramite formazioni d'impegno reciproco (26, 38) presentate dai rispetti mantelli (14, 28) dei due corpi (10, 12).(Figura 1).
Patent IT-TO960044-A1 (IT)
Title: Orizzontamento autoportante di tipo reticolare-spaziale per costruzio ni civili, industriali, rurali.
Inventor: BACIN ALDO
IPC: E04B/
Filed: 1996-01-25
Abstract: Il trovato prevede la realizzazione di orizzontamenti autoportanti per costruzioni civili, industriali, rurali con alto rapporto tra beneficio e costo, utilizzabili per solai calpestabili e di copertura di edifici civili, industriali, rurali, per passerelle aeree, ponticelli, rampe e simili; sono costituiti da una serie di nervature a sezione triangolare, tra loro ortogonali, con pareti oblique modellate come travi reticolari che hanno la peculiarità di avere in comune puntoni e tiranti con le travi adiacenti, e nodi rigidi.I pannelli di solaio, prefabbricati in stabilimento, possono essere utilizzati, così come sono, per coperture e passerelle aeree, mentre con il getto della soletta superiore il trovato è in grado di sostenere carichi più gravosi. Può essere ulteriormente rinforzato con l'esecuzione in opera di travetti interni alla struttura. Allo stato attuale della tecnica già esistono strutture similari, ma sono tutte realizzate in maniera molto più complessa ed onerosa.
Patent IT-TV920009-A1 (IT)
Title: Metodo di prevenzione particolarmente dell'alluce valgo e calzatura  con calza cosi' ottenuti
Inventor: MONETTI GIANPIETRO
IPC: A61F/
Filed: 1992-01-24
Abstract: Metodo per la prevenzione particolarmente dell'alluce valgo e calzatura con calza così ottenuti, consistendo nel prevedere soprattutto durante l'esercizio delle normali funzioni motorie la separazione dell'alluce dalle restanti dita, ottenuta mediante l'impiego di una protesi associata ad una calzatura tradizionale, detta protesi essendo costituita da una soletta in cui la parte terminale corrispondente al puntale della calzatura, prevede perpendicolarmente una parete divisoria infradito, disposta longitudinalmente e pressoché parallela ad un asse mediano passante per la calzatura.
Patent IT-VR930013-A1 (IT)
Title: Dna olfattivo
Inventor: ZIMMARO SANTE
Filed: 1993-02-22
Abstract: Rappresentazione olfattiva e caratteristica di personaggi di successo tramite "PROFUMO".
Patent IT-VT910001-A1 (IT)
Title: Sistema per lavaggio di tessuti e stoviglie a bassa temperatura o a   freddo, in bassa tensione con elettrodi in immersione
Inventor: PANDOLFO SALVATORE MARIO
IPC: D06F/
Filed: 1991-02-07
Abstract: IL NUOVO TROVATO SISTEMA DI LAVAGGIO SI AFFIDA, PER L'ATTIVAZIONE DEL DETERSIVO, AD UNO O PIU' ELETTRODI IMMERSI IN ACQUA E CONNESSI AD UN TRASFORMATORE, POSSIBILMENTE A "RILUTTANZA PILOTATA" ED ALIMENTATI IN BASSA TENSIONE, AD ES. 48 V.TALE SISTEMA PUO' ESSERE IMPIEGATO NELLE LAVABIANCHERIA E LAVASTOVIGLIE PER USO DOMESTICO O INDUSTRIALE, CON NOTEVOLE RISPARMIO ENERGETICO NELLA MISURA DI OLTRE IL 70%.
Patent NO-20100962-A1 (NO)
Title: System og fremgangsmate for konferanser med skalerbar mediesvitsjing
Inventor: BERGER ESPEN
IPC: H04N7/15
Filed: 2010-07-02
Abstract: System og fremgangsmåte for å utveksle audio-, video-og datainformasjon mellom i det minste to klienter i et kommunikasjonsnettverk, støttet av en sentral enhet. Fremgangsmåten omfatter trinnene å forbinde de i det minste to klientene til den sentrale enheten ved bruk av en samtalekontrollprotokoll, idet samtalekontrollprotokollen forhandler videoformater og forbindelsesinformasjon for sending og mottak av mediestrømmer: å transmittere informasjon fra en første klient til den sentrale enhet, idet informasjonen omfatter metadata som beskriver ulike mediestrømmer som den første klienten er i stand til å transmittere; å transmittere informasjonen mottatt fra den første klienten til den i det minste ene andre klienten: ved mottak av informasjonen om ulike mediestrømmer som den første klienten er i stand til å transmittere, å bestemme, i den i det minste ene andre klienten, hvilke av de tilgjengelige mediestrømmer fra den første klienten som den i det minste ene andre klienten vil abonnere på: å transmittere en abonneringsmelding fra den i det minste ene andre klienten til den sentrale enhet, å abonnere på i det minste en tilgjengelig mediestrøm fra den første klienten: ved mottak av i det minste en abonneringsmelding fra den i det minste ene andre klienten, å transmittere, av den sentrale enheten, en melding som fore spor den første klienten om å starte transmittering av mediestrømmer abonnert på av den i det minste ene andre klienten: å transmittere mediestrømmer abonnert på av den i det minste ene andre klienten fra den første klienten til den sentrale enhet; og å transmittere mediestrømmer abonnert på av den i det minste ene andre klienten fra den sentrale enhet til den i det minste ene andre klienten.
Patent NO-20150329-A1 (NO)
Title: Continuous band of plastic-coated paper for the production of bags for fruit and vegetable produce and similar products
Inventor: HUERTAS JOSÉ MARÍA MESEGUER
IPC: B65D30/10
Filed: 2015-03-16
Abstract: The invention relates to a continuous band of plastic-coated paper for the production of bags for fruit and vegetable produce and similar products, made from plastic-coated paper and provided with polyethylene reinforcements at the welding zones, the handles and, where applicable, along the periphery of the windows, in order to increase the mechanical strength thereof. The windows are closed with fragments of netting.
Patent PL-252061-A1 (PL)
Title: Method of obtaining phosphonic diesters
Inventor: LACROIX GYU
IPC: C07F9/38
Filed: 1985-02-21
Abstract: Phosphonic acid diesters having the formula:   <IMAGE>  in which R represents a hydrogenolysable group, preferably an aralkyl group, and R<1> represents a hydrolysable group, are obtained by a process wherein phosphonic acid esters of the formula (R<1>O)2P(O)H are reacted with formaldehyde and compounds of the formula R-NH-CH2-COOH, R and R<1> having the meanings given above. Compounds of the formula   <IMAGE> may be obtained by hydrogenolysis of the above compounds.
Patent PL-264819-A1 (PL)
Title: A device for upconnecting electric equipment or a transformer,especially for discharge lamps
IPC: H05B41/00
Filed: 1987-03-25
Abstract: - The adaptor is designed to screw (3) directly into a standard socket and has a socket element (4) that receives the pins of the lamp, e.g. small fluorescent tube. The centre element (1) of the adapter houses the inductance unit that forms part of the starter circuitry for the lamp. - The inductance (or choke) has a centre coil that locates on a 'U' shape core that is seated into the housing. A temperature sensitive fuse is coupled into the electrical connections to the pins.
Patent PL-292420-A1 (PL)
Title: Security and method of making same
Inventor: BOHM MICHAEL
IPC: D21H21/42
Filed: 1991-11-15
Abstract: The invention relates to a security document having an integral security element, preferably an optically variable element in the form of hologram, diffraction or interference structures applied to the paper surface, and to a process for making such a security document. The security document is characterised in that the optically variable element is embedded in the security document, the paper surface forming one plane with the surface of the optically variable element.
Patent PL-295030-A1 (PL)
Title: Method of obtaining substituted derivatives of 2-cyclohexan-1-yl amine
IPC: C07C327/14
Filed: 1991-10-18
Abstract: There are described new 2-cyclohexan-1-yl-amine derivatives of formula (I)    <IMAGE>  (I)  in which A, R1, R2, R3 and R4 have the meaning given in the description, and processes for their preparation. The compounds of the formula (I) are used as anti-microbial agents.
Patent PL-299690-A1 (PL)
Title: Pharmaceutical agent
Inventor: GIDDA JASWANT SINGH
IPC: A61P1/00
Filed: 1993-07-15
Abstract: Provided is a method of treating Irritable Bowel Syndrome (IBS) using a series of isoxazole derivatives that have both 5-HT1A agonist and M1 muscarinic activities, and formulations suitable therefor.
Patent PL-303716-A1 (PL)
Title: Lipopeptides from acinoplanes sp. exhibiting pharmacological action, method of obtaining them and their applications
Inventor: HAMMANN PETER
IPC: C07K/
Filed: 1994-06-06
Abstract: Lipo-peptides of formula (I), where R1 is a saturated or unsaturated, branched or unbranched, 6-22C fatty acid or hydroxy fatty acid residue other than those of formula (II)-(VII), are new:
Patent PL-309882-A1 (PL)
Title: Dna sequence encoding novel biosynthetic insulin precursors and insulin obtaining method
Inventor: MESTRIC SLIVIJA
IPC: C12N15/11
Filed: 1995-08-04
Abstract: The present invention relates to DNA sequences encoding insulin precursors of formula B-Pg-A, wherein B and A represent B- and A-chains, respectively, and Pg represents modified C-peptide or any number of amino acids comprising at least one glycosylation consensus site. The invention also relates to a process for the preparation of insulin by culturing suitable cells, preferably fungal cells, transformed with a vector comprising DNA sequence encoding insulin precursor of given formula. The invention further relates to DNA sequences encoding pharmaceutical peptides and proteins in which N-glycosylation consensus site is introduced in a non-essential site in any spacer region for higher expression and secretion of proteins.
Patent PL-315168-A1 (PL)
Title: Contraception set
Inventor: SPONA JUERGEN
IPC: A61K31/58
Filed: 1994-12-22
Abstract: Conception is prevented in a fertile female who has not reached the pre-menopause by the admin. over a 28 day cycle of a combination of: (a) an estrogen content comprising: 2-6 mg 17beta -oestradiol or 0.015-ethynyloestradiol; and (b) a gestagen content comprising: 0.05-0.075 mg gestodene; 0.075-0.125 mg levonorgestrel; 0.06-0.15 mg desogestrel or 3-ketodesogestrel; 0.1-0.3 mg drospirenone; 0.1-0.2 mg cyproterone acetate; 0.2-0.3 mg norgestimate or > 0.35 mg to 0.75 mg norethisterone; for 23 or 24 days commencing on day 1 of the menstruation cycle followed by 5 or 4 days without this medication or with a placebo. Also claimed is a contraceptive pack contg. 23 or 24 dosage units contg. the oestrogen and gestagen components and 5 or 4 placebos or other instructions to the effect that 5 or 4 days without medicament or with placebo should follow the admin. of a dosage unit for 23 or 24 consecutive days; with the estrogen content being: > 2 mg to 6 mg oestradiol or 0.02 mg ethynyloestradiol; and the gestagen content being: above 0.06-0.075 mg gestodene, > 0.1-0.125 mg levonorgestrel, > 0.1-0.15 mg desogestrel or 3-ketodesogestrel, 0.25-0.3 mg drospirenone, 0.1-0.2 mg cyproterone acetate, 0.2-0.3 mg norgestimate or 0.5-0.75 mg norethisterone.
Patent PL-319305-A1 (PL)
Title: Balanced oscillator and machine incorporating such oscillator
Inventor: SKAK VALDEMAR
IPC: B65G65/44
Filed: 1995-09-08
Abstract: PCT No. PCT/DK95/00361 Sec. 371 Date Mar. 19, 1997 Sec. 102(e) Date Mar. 19, 1997 PCT Filed Sep. 8, 1995 PCT Pub. No. WO96/09126 PCT Pub. Date Mar. 28, 1996A balanced vibration generator (1) for resonance-amplified operation of a machine or equipment (20) comprises at least one set of counter-oscillating masses (4, 16, 20) suspended in a spring system (3) in which the resonance springs are helical springs which also support the masses. The generator comprises a built-in, balanced drive system (6, 7, 8). The generator is suspended in securing elements (10, 11) which comprise special, adjustable securing elements (9) which are in engagement with the resonance springs (3) and arranged in such a manner that the resonance springs, when turned around their longitudinal axes (14), can change spring lengths.
Patent PL-321595-A1 (PL)
Title: Organic structure carrier for on-wire assembling
Inventor: BHATT ASHWINKUMAR CHINUPRASAD
IPC: H05K7/02
Filed: 1996-01-17
Abstract: A chip carrier for wire bond-type chips is disclosed. This chip carrier employs organic dielectric materials, rather than ceramic materials, as is conventional. This chip carrier also employs at least one organic, photoimageable dielectric layer, having plated photo-vias, to electrically interconnect two (or more) layers of fan-out circuitry. This chip carrier further employs a single-tiered cavity to contain a chip, rather than a multi-tiered cavity, as is conventional. Moreover, this chip carrier includes thermal via holes and/or a metallic layer, directly beneath the chip, to enhance heat dissipation.
Patent PL-322582-A1 (PL)
Title: Apparatus for storing at least one elastically deformable fasteners and sectional concrete placing method employing such fasteners as jointing elements in the concrete placing process
Inventor: NOTARFRANCESCO THOMAS
IPC: E04G21/14
Filed: 1996-04-04
Abstract: The invention concerns a support device for at least one elastically deformable securing element (2) such as a wire cable loop, for securing building components such as precast concrete parts, in particular as a concrete connection for section concreting. The device is provided with at least one support box (1) and means for bending the securing element (2) and means for positioning the securing element in relation to the support box. The bending means comprise at least two bending stops (40, 42) and a counter stop (41). In order to simplify handling, specifically the assembly of such a support device, at least one moulded element (3, 3a) is provided which serves as a positioning means and has a bending stop (40). This moulded element is or can be clicked into the support box (1) in a way which makes it angularly rigid. The bending stop (40) of the moulded element counteracts any bending forces which arise, at least parallel to the surface of the component to be secured. The support box can hold one part of the elastically deformable securing element (2) until the component can be stripped of the outer shell.
Patent PL-324339-A1 (PL)
Title: Novel analoques of campotectin, methods of obtaining them and applying them as medicines as well as pharmaceutic compounds containing them
Inventor: BIGG DENNIS
IPC: C07D487/04
Filed: 1996-06-21
Abstract: Camptothecin analogues where the camptothecin hydroxy lactone is: (i) a  beta -hydroxy lactone; or (ii) the corresp.  beta -hydroxy acid resulting from ring-opening of the aforementioned lactone; or a (iii) deriv. of the  beta -hydroxy acid in (ii) or its one of its salts. Also claimed are new industrial prods. of formula (M) and (A). R1 = lower alkyl, lower alkenyl, lower alkynyl, halo(lower alkyl), lower alkoxy(lower alkyl) or lower alkylthio(lower alkyl); R20 = H or halo; R22 = F, Cl, or lower alkoxy; R23 = prim. hydroxy-protecting gp.; and R18, R19 = H, halo, lower alkyl, lower alkoxy or OH.
Patent PL-324795-A1 (PL)
Title: Application of adamantane derivatives in treating internal ear diseases
Inventor: RUPPERSBERG J PETER
IPC: A61K31/13
Filed: 1996-07-31
Abstract: Use of adamantane amine of formula (I) and their salts for treating diseases of the inner ear is new. R1,R2,R5 = H or 1-6C alkyl; or NR1R2 = 5-6-membered heterocycle; and R3,R4 = H, 1-6C alkyl, 5-6C cycloalkyl or phenyl.
Patent PL-328310-A1 (PL)
Title: Derivatives of quinazoline
Inventor: THOMAS ANDREW PETER
IPC: C07D239/93
Filed: 1997-02-10
Abstract: The invention relates to quinazoline derivatives of formula (I)wherein: Z represents -O-, -NH- or -S-; m is an integer from 1 to 5; R1 represents hydrogen, hydroxy, halogeno, nitro, trifluorometlyl, cyano, C1-3alkyl, C1-3alkoxy, C1-3alkylthio or NR5R6 (wherein R5 and R6, which may be the same or different, each represents hydrogen or C1-3alkyl); R2 represents hydrogen, hydroxy, halogeno, methoxy, amino, or nitro; R3 represents hydroxy, halogeno, C1-3alkyl, C1-3alkoxy, C1-3alkanoyloxy, trifluoromethyl, cyano, amino or nitro; X1 represents -O-, -CH2-, -S-, -SO-, SO2-, -NR6-, NR8CO-, -CONR9-SO2NR10- or -NR11SO2-, (wherein R7, R8, R9, R10 and R11 each represents C1-3alkyl, C1-3alkoxyC2-3alkyl); R4 represents a group which is alkenyl, alkynyl or optionally substituted alkyl, which alkyl group may contain a heteroatom linking group, which alkenyl, alkynyl or alkyl group may carry a terminal optionally substituted 5 or 6 membered saturated carbocylic or heterocyclic group; and salts thereof, processes for their preparation, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient the compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.