baber/WOPTO huggingface dataset:
Patent CN-201380787-Y (CN)
Inventor: FUMING HE
IPC: B62D63/00
Filed: 2009-02-25
Granted: 2010-01-13
Abstract: 本实用新型属于冶金行业生产设备的辅助工具，具体涉及一种新型电动平板车，它包括车板、车轮、电动机、减速器，车板的底部设置车轮、电动机、减速器，其特征是车板上设置若干块支撑板，车板的底部还固定安装有电动机，电动机的轴上安装接触器和绕线轴。本实用新型车板的四侧均设置支撑板，无论车板向那个方向倾斜，支撑板均可起到支撑的作用，不会发生侧翻现象；绕线轴将拖在地面的电源线缠绕起来，避免发生漏电现象。
Patent CN-201350790-Y (CN)
Title: 一种带日历的笔筒
Inventor: CHENGFANG WU
IPC: B43M99/00
Filed: 2009-02-12
Granted: 2009-11-25
Abstract: 本实用新型公开了一种带日历的笔筒，它包括底座和固定于底座上的筒体，还有一日历固定于底座上。本实用新型的优点在于：本实用新型的笔筒，既有盛笔的功能，又带有日历，可随时查看日历，方便实用。
Patent CN-201385917-Y (CN)
Inventor: YANMEI YANG
IPC: B65F1/14
Filed: 2009-02-24
Granted: 2010-01-20
Abstract: 多箱体式垃圾分类收集箱，用于生活垃圾的分类收集。该垃圾箱由八个箱体组成，各箱体内部分别放置有对应的铁皮内桶，箱体顶部均设有垃圾投放与收运顶盖。该垃圾箱可以为厨余、玻璃、纸张、塑料、金属、废旧电池、有毒有害垃圾和废木头与泡沫等其它无害垃圾的分类收集提供相对独立的收集空间。它可以避免玻璃物质与厨余的混合收集；可以在垃圾收集的过程中为最大限度地避免有毒有害物质混入普通垃圾中提供收集设施的保障；另外它还为有机厨余、玻璃、纸张、塑料、一般金属与废旧电池中有用金属等物资的后续资源化循环奠定良好的收集渠道基础。该垃圾箱的应用可以促进生活垃圾的高效处理与资源化利用，非常符合循环经济的理念，适合用作为文明小区的垃圾收集装置。
Patent CN-201401236-Y (CN)
Inventor: RENZHEN HE
IPC: G05B19/048
Filed: 2009-04-30
Granted: 2010-02-10
Abstract: 本实用新型公开一种沼气发电机组新型控制系统，包括系统控制器、发动机转速传感器、机油压力传感器、蓄电池电压传感器、冷却水水温传感器、电压电流传感器、混水阀、冷却水及废气－水热转化系统、GPRS通讯模块、沼气发电机组状态显示及参数设定显示器、操作面板、电子调节器和发动机点火系统，特点为在系统控制器外部相应的功能引脚上连接有发动机转速传感器、机油压力传感器、蓄电池电压传感器、冷却水水温传感器、电压电流传感器、混水阀、冷却水及废气－水热转化系统、GPRS通讯模块、电子调节器和发动机点火系统，沼气发电机组状态显示及参数设定显示器和操作面板通过相应接口连接在系统控制器上。故能控制发电机组启动、运行和停机。
Patent GE-U199445-Y (GE)
Title: The Automatic Waterheater "Gvalia-46"
Inventor: GVALIA GIVI
IPC: F24H1/20
Filed: 1994-02-08
Abstract: The utility model refers to the thermal power and can be used in the water heaters. The technical result of the utility model is in the possibility of simplifying the construction, in reducing the clearance, decreasing the specific quantity of metal, also in protecting the device from overheating. The automatic waterheater comprises the cylinder case 1 with inputting and outputting tubes 2 and 3, the lower and upper plugs 5 and 6, the heating element 15. In the case 1 the piston 9 is setted by the coaxialy equipped valve 12, comprising the contact 14. The lower and upper plugs 5 and 6 comprise the contacts 7 and 8. The one end of the heating element 15 is attached to the contact 7, and the other to the springloaded contact 14. Among the piston 9 and the upper plug 6, the spring 16 is setted. 1 fig.
Patent MD-1245-Z (MD)
Title: Method for diagnosis of viral hepatitis B in persons with accidental exposure
Inventor: SPÂNU Constantin
IPC: G01N33/577
Filed: 2017-09-06
Abstract: The invention relates to medicine, namely to a method for diagnosis of viral hepatitis B with the determination of AgHBs and its subsequent confirmation in persons with accidental exposure such as medical personnel, drug users, patients undergoing hemodialysis treatment, etc.Summary of the invention consists in that in two strips with wells is used AgHBs free human serum, human serum negative to AgHBs antibodies, serum with antibodies to AgHBs with a titer of more than 100 IU/ml and serum of the human being tested in the first strip, and in the second strip is used AgHBs free human serum, fetal bovine serum for calibration, inactivated human serum, containing calibrated AgHBs and serum of the human being tested. After incubation at a temperature of 18…24°C, for 30 min, diluted conjugate 1:20 of rabbit or mouse anti-species globulin and horseradish peroxidase is added in all samples, then the samples are incubated at a temperature of 37°C, for 120 min. Further, a chromogen solution containing 0.02% hydrogen peroxide solution, 4% dimethylsulfoxide solution and 0.03% tetramethylbenzidine solution is added and incubated at a temperature of 18…24°C, for 30 min, after which the optical density values are determined by the photometric method at the wavelength of 450…620 nm.
Patent MD-1332-Z (MD)
Title: Small-sized graft fixation and cellularization device
Inventor: COBZAC VITALIE
IPC: A61L2/02
Filed: 2018-07-02
Abstract: The invention relates to regenerative medicine and tissue engineering, in particular to a small-sized graft fixation and cellularization device.The small-sized graft fixation and cellularization device comprises an Eppendorf-type cone-shaped container, in the upper part of which is fixed a removable cover with a central hole. In the body of the container on two sides are oppositely placed two holes, and in the lower part of the container is made a through hole. Inside the container is coaxially placed a removable cone-shaped holder for grafts, directed with the small base in the lower part of the container, with the possibility of passing through the hole made in the lower part of the container, the outer diameter of the holder being equal to the diameter of the container's hole. The length of the holder exceeds the length of the container, and all components of the device are made of polypropylene and autoclavable.
Patent PE-20121285-Z (PE)
Title: Rack manipulado a control remoto
Inventor: LAUREANO NATIVIDAD WALTER GILVER
IPC: F16M11/04
Filed: 2012-04-25
Abstract: REFERIDO A UN SOPORTE AEREO MANIPULADO A CONTROL REMOTO COMPUESTO POR UN BRAZO SOPORTE ALOJADO POR LA PARTE DETRAS A UNA BISAGRA FIJA ANCLADA A LA PARED O TECHO Y UN EJE CALIBRADO POR LA PARTE DELANTERA EN EL CUAL SE ALOJA A DOS RODAMIENTOS Y A DOS ARANDELAS. EL BRAZO SOPORTE INCORPORA TAMBIEN A UNA ABRAZADERA QUE SOSTIENE A UNA FUENTE DE ENERGIA Y UN RECEPTOR DE SENALES ELECTROMAGNETICAS, ASI TAMBIEN INCORPORA A UN SOPORTE DE MOTOR, QUE UNIDA A UNA PLACA PORTA TV QUE SE FIJA AL ESPALDAR DEL TELEVISOR Y ESTE A SU VEZ SE FIJA A LA PLACA DE INCLINACION COMPLEMENTANDOSE SU FUNCIONALIDAD CON LA BISAGRA PORTA PLACA DE INCLINACION. LOS MOVIMIENTOS DEL SISTEMA SON ACCIONADOS POR DOS MOTORES ELECTRICOS CON REDUCTORES DE VELOCIDAD Y DE 12V, CADA UNO POSICIONADOS VERTICAL Y HORIZONTALMENTE, LOS CUALES ESTAN MONTADOS SOBRE EL BRAZO SOPORTE Y SOBRE EL PORTA MECANISMO DE ARTICULACION. LA ROTACION DEL MOTOR ACCIONA EL GIRO LATERAL HORIZONTALMENTE DEL SISTEMA, MEDIANTE LA BISAGRA PORTA PLACA DE INCLINACION Y EL EJE PORTA RODAMIENTOS. LA ROTACION DEL MOTOR ACCIONA EL MOVIMIENTO DE INCLINACION POR MEDIO DEL EJE GIRATORIO CON ROSCA INTERIOR EL CUAL EMPUJA AL EJE ROSCADO Y ESTE A SU VEZ ACCIONA LA BARRA DE ARTICULACION POR MEDIO DEL SOPORTE DE ARTICULACION OBTENIENDOSE ASI UNA INCLINACION DEL SISTEMA CON MAXIMO DE 30° VERTICALMENTE
Patent PE-20191212-Z (PE)
Title: Grapa tipo cayman para suspension de cables
Inventor: DE LA CRUZ ALARCON ANGEL ENRIQUE
IPC: F16L3/01
Filed: 2018-08-08
Abstract: Un dispositivo para la suspension de cables y fijacion a postes y similares del tipo que comprende una plancha superior que presenta al menos una semihendidura y plancha inferior que presenta al menos una semihendidura, unidas a una plancha superior caracterizado porque la plancha inferior y la plancha superior estan unidas a una plancha transversal por un extremo, donde dicha plancha transversal presenta unos orificios diametralmente opuestos.
Patent PE-20191658-Z (PE)
Title: Patineta electrica retroalimentada con control inteligente de velocidad
Inventor: FLORES PEREZ SEBASTIAN GABRIEL
IPC: A63C17/00
Filed: 2019-10-25
Abstract: Es una patineta electrica retroalimentada con control inteligente de velocidad compuesta por un microcontrolador, 2 motores (uno que funciona como dinamo), un sensor de velocidad, un transductor, un transmisor, un controlador de motor y una bateria. La cual cuenta con las siguientes ventajas tecnicas: sistema de regulacion de velocidad automatico, capacidad de cargarse sin uso de tomacorriente, evita la contaminacion ambiental al cargarse/recargarse por medio de energia cinetica, disminucion del tiempo de carga de la bateria.
Patent PE-20230027-Z (PE)
Title: Horno ecologico para hornear carnero, chancho al palo y otras carnes
Inventor: SURCO HACHIRI BERNARDINO JULIO
IPC: A21B1/44
Filed: 2022-03-23
Abstract: La presente invencion se refiere a un horno ecologico para el horneado de carnero y chancho al palo conformado por un chasis o estructura metalica en acero inoxidable (1) de forma de un paralelepipedo, un techo de forma piramidal (2) que presenta una abertura o agujero central (2.1) por donde se extraen gases o vapores , ruedas o garruchas (3) en sus cuatro esquinas inferiores, en su cara frontal por dos puertas (4) de vidrio templado con manijas de baquelita (4.1), en su parte inferior un cajon (5) que contiene una bandeja de recoleccion de jugos y grasas (fluidos) y en su lado lateral izquierdo un panel alargado con perillas (6.1 ,6.2) y tablero de control para el funcionamiento del horno (1), quemadores infrarrojos (7,8) en su pared posterior, cuatro (4) ruedas o garruchas (3) en sus esquinas inferiores, rejillas de ventilacion (9) y un sistema de transmision de movimiento (18), Caracterizado porque comprende: Dos parrillas tipo reja, una superior (10) y otra inferior (11) y dos niveles de seis quemadores infrarrojos (7,8) paralelos y verticalmente en la pared posterior del horno (1) alineados a las parillas (10, 11), respectivamente, las parrillas (10, 11) estan conectadas a sus paredes laterales a traves de soportes, siendo el soporte izquierdo (13) para el arrastre motriz, lo cual esta conectado a su vez a un sistema de transmision (18) para su movimiento, el que hace girar a las parrillas sobre su propio eje en sentido horario por medio de manijas de manipulacion (15); siendo que la distancia optima que debe existir entre el punto medio de cada parilla con su seccion abatible (alineada a la manija de manipulacion o eje de giro) y los quemadores infrarrojos (10, 11) en la pared posterior del horno, debe estar entre 0,50m a 0,55m (50cm a 55cm), y la distancia de separacion entre quemadores infrarrojos entre 0,18m a 0,21 m (18cm a 21 cm); y el nivel optimo de la altura a la que deben quedar los quemadores infrarrojos (7,8) respecto a la posicion horizontal de las parrillas tipo reja (10, 11) es que nivel de sus extremos superiores quede alineado a la altura de cada parrilla en posicion horizontal, es decir, alineado a su nivel superior y hacia abajo; En su lado lateral izquierdo, un sistema de transmision del movimiento (rotacion) (18) de las parrillas tipo reja (10, 11) conformado por un motor (18. 1), una caja reductora (18.2) de funcionamiento silencioso, pinones de cadena (18.3) en su parte superior e inferior, cadenas (18.4) y faja de funcionamiento del motor (18.5), encontrandose dicho sistema de transmision alineado respectivamente a cada una de las alturas de los ejes de giro de las parrillas tipo reja.
Patent PE-20230958-Z (PE)
Title: Aparato portatil para eliminar patogenos en el agua dulce de acuarios que produce nanoburbujas de ozono
Inventor: DURAND TORRES JULIO ERNESTO
IPC: C01B13/11
Filed: 2022-10-03
Abstract: Un aparato portatil que se instala y desinstala dentro del agua dulce de un acuario habitado por especies acuaticas, que genera de una manera variable y controlada nanoburbujas de ozono por electrolisis, y complementariamente nanoburbujas de oxigeno por electrolisis, para eliminar los patogenos en el agua sin provocar un riesgo a la salud de las especies habitantes del acuario, que comprende: un grupo de elementos de filtracion de agua; una bomba de agua sumergible; un generador electrolitico de ozono con un requerimiento de potencia de muy baja tension; un generador electrolitico de oxigeno con un requerimiento de potencia de muy baja tension; un soporte de material dielectrico; una camara de aislamiento de material dielectrico; un cable electrico; y un controlador externo con una interfaz de usuario y una unidad de suministro de potencia para aplicar potencia al aparato portatil.
Patent ES-499625-A0 (ES)
IPC: C13K1/02
Filed: 1981-02-20
Abstract: PCT No. PCT/DE81/00036 Sec. 371 Date Oct. 15, 1981 Sec. 102(e) Date Oct. 15, 1981 PCT Filed Feb. 21, 1981 PCT Pub. No. WO81/02428 PCT Pub. Date Sep. 3, 1981.Process and apparatus for the continuous hydrolysis of plant biomass containing cellulose and hemicellulose. Chopped biomass is treated in a first stage in the presence of dilute acid, at temperatures and pressure conditions under which the hemicellulose and, partially, the cellulose are hydrolyzed during a first reaction to pentoses and partially, hexoses, whereupon the reaction mixture pressure is suddenly released and the hydrolysate is separated from the biomass, and in at least a further stage, cellulose in the biomass is hydrolyzed in the presence of dilute mineral acid and under more severe temperature and pressure conditions, to hexoses, whereupon again the reaction mixture pressure is suddenly released and the hydrolysate is separated from the remaining biomass, and in which the neutralized hydrolysate, is further processed for the production of sugars, wherein each hydrolysis stage comprises as reaction chamber, a continuously operating horizontal tube digester containing horizontal conveyor devices, the digester being connected on the entrance side with a conical worm filler with a perforated cone casing for the injection of the biomass and the outlet side is fitted with an outlet device which forms a pressure seal of the exit side of the reaction chamber, and which is connected via a blow pipe with a cyclone-shaped blow tank.
Patent ES-516903-A0 (ES)
IPC: B65D17/347
Filed: 1982-10-28
Abstract: In a sheet metal or plastic container for storing beverages or the like a plug member is located against an opening region provided in the container's end wall and defined by a score line. The plug member has a closing peripheral edge which has the same geometry as the peripheral edge of the opening resulted after the score line is ruptured by external pressure applied to the plug member towards the interior of the container. The plug member and the opening region after it has been ruptured are slidably displaced from the opening to expose the latter. That opening can be tightly closed again by the plug member inserted at that peripheral edge into the opening.
Patent ES-517825-A0 (ES)
IPC: A61D1/08
Filed: 1982-11-30
Abstract: Device for veterinary obstetrical delivery that can be placed against the body of the dam, that has a support (1) that is positioned in relation to the body of the dam, a rod (2) that is mounted on and can be connected to the side of the support facing away from the body, and a tensioning mechanism (3) mounted on the rod and provided with hooks (4) on which can be suspended slings for the legs of the new-born animal. To prevent injury to the subvaginal region of the body of the dam during delivery as the result of the direct action of the support, the support is mounted to pivot in one end of the rod.
Patent ES-532791-A0 (ES)
IPC: A61K31/44
Filed: 1984-05-24
Abstract: A 1,4-dihydropyridine derivative of the formula   <IMAGE>   in which R and R1 each independently is hydrogen, C1-C4-alkyl, C1 to C12-alkoxy, C1-C4-halogenoalkoxy, halogen, nitro, trifluoromethyl, <IMAGE>   <IMAGE>  X is oxygen or sulphur, R4 and R5 each independently is hydrogen, C1-C4-alkyl, C1-C6-alkoxy, halogen, trifluoromethyl, amino or nitro, and R2 and R3 each independently is hydrogen, a C1-C10-alkyl, C2-C10-alkenyl or C3-C10-alkinyl radical which is optionally substituted by halogen, hydroxyl, C1-C4-alkoxy, amino, mono- and di-C1-C4-alkylamino, carbo-C1-C6-alkoxy and/or nitro, a C3 to C6-membered cycloalkyl radical, a phenyl radical which is optionally substituted by C1-C4-alkyl, C1-C6-alkoxy, halogen, amino and/or nitro, or a phenyl-C1-C3-alkyl radical, or a carbohydrate radical which is optionally bonded via a C1-C8-alkyl chain to the amide nitrogen atom or a pharmaceutically acceptable acid addition salt thereof, which improves the contractility of the heart, raises the blood pressure, lowers the blood sugar, reduces the swelling of mucous membranes and affects the salt and fluid balances of a patient.
Patent ES-540737-A0 (ES)
IPC: C08L53/02
Filed: 1985-02-27
Abstract: Resinous polymodal block copolymers of such as butadiene and styrene which are craze-resistant, transparent, and substantially color-free, and methods of producing the block copolymers. The copolymers are prepared by sequential charge copolymerization modes comprising the solution polymerization of at least two charges each of a conjugated diene, a monovinylarene, and a monoalkali metal initiator, at least one charge of conjugated diene monomer precedes the last charge of monoalkali metal initiator, at least one charge each of monovinylarene and of conjugated diene follows the last charge of monoalkali metal initiator, and the final charge of monomer is a charge of conjugated diene monomer, such that the number of charges of each of said components is not more than three, and the total of the charges of the three components is 8 or 9.
Patent ES-555135-A0 (ES)
IPC: C21C7/068
Filed: 1986-05-20
Abstract: A steelmaking method which enables accurate prediction of the split of top-injected oxygen between that which reacts with the bath and that which reacts with carbon monoxide above the bath.
Patent FI-842380-A0 (FI)
Inventor: LAGERSTROEM GOESTA BERTIL
IPC: C01B33/18
Filed: 1984-06-12
Abstract: The present invention relates to a method for purifying silica waste obtained in the manufacture of aluminium fluoride from hexafluosilicic acid and aluminium hydroxide, whereby the silica, is subjected to an acidic leaching at a pH below 3 to leach out part of the fluorine and substantially all the aluminium present in said waste, and is thereafter subjected to an alkaline leaching at pH 8.5-11.5 to leach out remaining fluorine present in said waste. The teachings are preferably carried out at elevated temperatures, normally 60-90°C, and for a time sufficient to considerably reduce the contents of aluminium and fluorine, normally 1-3 hrs.The silica obtained is highly reactive and can be used as such or transformed into sodium slicate by a reaction with sodium hydroxide. The contents of fluorine and aluminium can be transferred to a process for the production of cryolite or similar compounds.
Patent FI-844934-A0 (FI)
Inventor: GRAY PATRICK WILLIAM
IPC: C07K1/20
Filed: 1984-12-13
Abstract: The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino acid sequence of such an interferon comprises, from the N terminus, at leastwherein X is a methionine residue or hydrogen and Y is a glutamine residue or, where X is is hydrogen, Y is either a glutamine or a pyroglutamate residue.
Patent FI-873456-A0 (FI)
Inventor: TURNER HOWARD WILLIAM
IPC: C08F10/00
Filed: 1987-08-10
Abstract: An olefin polymerization catalyst comprises the reaction product of a metallocene complex of Group IVB, VB, VIb, and VIII of the Periodic Table and an excess of alumoxane.
Patent FI-885094-A0 (FI)
Inventor: BURNS CHARLENE LOUISE
IPC: A61K31/7052
Filed: 1988-11-04
Abstract: Certain 3'-fluoro pyrimidine and purine nucleosides have been found to have potent antiviral activity particularly against Human Immunodeficiency Virus (HIV).
Patent FI-891249-A0 (FI)
Inventor: GRUNDMANN ULRICH
IPC: C12N15/12
Filed: 1989-03-16
Abstract: The cDNA coding for PP15 is described. This cDNA can be used to prepare PP15 in pro- or eukaryotic cells. <IMAGE>
Patent FI-924497-A0 (FI)
Inventor: KLOCKARS ANDERS BENGT OLOF
IPC: B65G25/08
Filed: 1992-10-06
Abstract: PCT No. PCT/FI93/00401 Sec. 371 Date Jun. 5, 1995 Sec. 102(e) Date Jun. 5, 1995 PCT Filed Oct. 6, 1993 PCT Pub. No. WO94/07779 PCT Pub. Date Apr. 14, 1994The present invention relates to an operating system for moving a feed apparatus of elongated pieces of timber, particularly logs, into a transversal feed apparatus, for moving reciprocatingly the feed apparatus, the feed apparatus being arranged to feed pieces of timber piece by piece from a reception point (7) to a discharge point (8) and the feed apparatus having a step-like configuration and the feed apparatus comprising a reception step member (1), which is movable reciprocatingly between the initial position thereof, in which the upper surface part (9) of the reception step member is substantially on the level of the reception point (7), and the discharge position, and a discharge step member (4), which is movable back and forth between the discharge position thereof, in which the upper surface part (15) of the discharge step member is substantially on the level of said discharge point, and the reception position thereof, and possibly one of more additional step members (2, 3). The feed apparatus is used in an operating system (17) comprising a crank system (18, 19, 20) operating the step members (1, 2, 3, 4).
Patent FI-931029-A0 (FI)
Inventor: FRASE HANS-JUERGEN
IPC: H05K9/00
Filed: 1993-03-09
Abstract: This security device exhibits a container (1), protected against external trouble factors such as fire, moisture, water penetration, combustion gas and magnetic fields and secured against intrusion, for accommodating and operating an electronic computer (2). The container (1) consists of a multi-walled container casing (3) constructed as Faraday cage, having at least one door (4) and an installation wall (5) for mounting operating devices for the computer (2). Door (4) and installation wall (5) can be removed from the container casing (3) of the container (1) for transportation and display purposes. An air conditioning system (6) is installed in the container casing (3). <IMAGE>
Patent FI-933992-A0 (FI)
Inventor: VON RAVEN AXEL
IPC: C09D7/41
Filed: 1993-09-10
Abstract: The addition of photosensitising compounds to inorganic fillers and pigments to improve the degree of whiteness, the brightness and the colour location, and the fillers, pigments and mixtures thereof obtained thereby, and their use in, for example, the manufacture of paper.
Patent FI-934933-A0 (FI)
Inventor: CANDIANI ILARIA
IPC: C07D457/06
Filed: 1993-11-08
Abstract: The invention provides a process for the preparation of ergoline derivatives of the formula I    <IMAGE>  I  the process comprising reacting an ergoline amide of the formula II with an isocyanate of formula III   <IMAGE>   in presence of a metal catalyst and of a phosphorus compound. The compounds of the formula I are useful antiprolactinic and antiparkinson agents.
Patent FI-935380-A0 (FI)
Inventor: BIRRENBACH GERD
IPC: A61K9/50
Filed: 1993-12-01
Abstract: Fast-release S(+)-ibuprofen pellets with a bioavailability comparable to commercially available racemate formulations are proposed. The rapid release of the active substance is promoted by the use of small amounts of basic inorganic salts, preferably sodium carbonate, or dilute alkali metal hydroxide solutions. It is possible in this way to obtain pellets with an active substance content of 90-99% by weight. The Tablets are suitable for application of coatings. Tablets can be directly compressed from pellets with a protective coating in this form and with small amounts of suitable tabletting auxiliaries. By use of the pharmacologically active S(+)-ibuprofen and of the small amounts of auxiliaries necessary it is possible to produce compact pharmaceutical forms.
Patent FI-941808-A0 (FI)
Inventor: GODEK DENNIS M
IPC: C07C47/575
Filed: 1994-04-19
Abstract: A novel two-step reaction process for preparing 5-substituted-2-methoxybenzaldehyde compounds is disclosed wherein the substituent group is either isopropyl or trifluoromethoxy. The process involves (1) reacting a corresponding 4-substituted phenol compound with dimethyl carbonate in the presence of a tertiary-amine base to form the corresponding 4-substituted anisole compound, and (2) thereafter subjecting the latter intermediate product obtained in the first step to aromatic C-formylation on the ring with hexamethylenetetramine in the presence of trifluoroacetic acid, followed by hydrolysis, to ultimately yield the desired aldehyde compound. The two aromatic aldehyde compounds so obtained, viz., 2-methoxy-5-trifluoromethoxybenzaldehyde and 2-methoxy-5-isopropylbenzaldehyde, are known to be useful as intermediates that specifically lead to (2S,3S)-cis-3-(2-methoxy-5-trifluoromethoxybenzyl)amino-2-phenylpiperidine and (2S,3S)-cis-2-(diphenylmethyl)-N-((2-methoxy-5-isopropylphenyl)methyl)-1-azabicyclo(2.2.2)octane-3-amine, respectively. The latter final products, in turn, are both known to be useful in the field of medicinal chemistry as substance P receptor antagonists.