Patent SG-11201810116V-A (SG)
Title: Exosomes comprising therapeutic polypeptides
Inventor: HEAN JUSTIN
IPC: A61K47/65
Filed: 2017-05-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111 010111010 11111 0 01 010 11111 001 0111 100 110 111110 1111 0111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/203260 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 41/00 (2006.01) A61K 47/64 (2017.01) KM, ML, MR, NE, SN, TD, TG). A61K 47/65 (2017.01) (21) International Application Number: Published: PCT/GB2017/051479 — with international search report (Art. 21(3)) (22) International Filing Date: 25 May 2017 (25.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1609216.5 25 May 2016 (25.05.2016) GB (71) Applicants: EVOX THERAPEUTICS LTD [GB/GB]; 2nd Floor, King Charles House, Park End Street, Ox- ford OX1 9QT (GB). OXFORD UNIVERSITY INNO- VATION [GB/GB]; Buxton Court, 3 West Way, Oxford OX2 OJB (GB). (72) Inventors: HEAN, Justin; 17 Aldrich Road, Oxford OX2 _ 7SS (GB). MAGER, Imre; 19 Hadow Road, Oxford OX2 OJW (GB). WOOD, Matthew; 13 Leckford Road, Oxford = OX2 6HY (GB). EL ANDALOUSSI, Samir; Enrisvagen 14, 14131 Huddinge (SE). WIKLANDER, Oscar; Greta = Garbos vag 21B, 16940 Solna (SE). NORDIN, Joel; Hilde- vergsvagen 12, 11762 Stockholm (SE). — = Agent: HEARE-ROWLANDS, Tanya; Cooley (UK) (74) = LLP, Dashwood, 69 Old Broad Street, London EC2M 1QS = = (GB). Designated States (unless otherwise indicated, for every (81) = kind of national available): AE, AG, AL, AM, protection = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, = KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = = SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = — TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = — (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, — 1-1 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, .4 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 0 ei MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, en © (54) Title: EXOSOMES COMPRISING THERAPEUTIC POLYPEPTIDES ei ---- (57) : The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular IN and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide con- 0 structs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention N pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments re- n lated to the inventive EVs.