baber/WOPTO huggingface dataset:
Patent BR-PI0914649-B1 (BR)
Title: Pirazolo-quinazolinas
Inventor: HELENA POSTERI
IPC: C07D487/04
Filed: 2009-06-17
Abstract: pirazolo-quinazolinas a presente invenção se refere a pirazolo-quinazolinas, caracterizado por resíduos heterociclílamino ou cicloalquilamino c3-c7 na arilamino susbtituído na posição orto, e um aril, heterociclil ou cicloalquil c3-c7, como substituinte de uma carboxamida na posição 3 da estrutura molecular. os compostos desta invenção modulam a atividade de quinases de proteína e são, portanto, úteis no tratamento de doenças causadas pela atividade desregulada da proteína quinase, em particular mps1/ttk. a presente invenção também fornece métodos para preparar estes compostos, composições farmacêuticas que contêm estes compostos.
Patent BR-PI1003190-B1 (BR)
Title: cabeça de descarga de líquido e método para fabricar a mesma
Inventor: KAZUHIRO ASAI
IPC: B41J2/135
Filed: 2010-08-23
Abstract: cabeça de descarga de líquido e método para fabricar a mesma. uma cabeça de descarga de líquido da presente invenção compreende um substrato e um membro de parede de trajeto de fluxo previsto sobre o substrato e tendo uma parede de um trajeto de fluxo comunicada com um orificio de descarga para descarregar líquido, na qual o membro de parede de trajeto de fluxo é munido de uma cavidade não comunicada com o trajeto de fluxo, quando visualizada em uma direção do orificio de descarga no sentido do dito subsirato. a dita cavidade tem a forma de um caractere, e o caractere corresponde à informação relativa à cabeça de descarga de líquido.
Patent BR-PI1006589-B1 (BR)
Title: Equipamento e método compreendendo um primeiro dispositivo sem fio para realizar uma primeira sequência de comunicações em um canal social designado para descoberta de um segundo dispositivo sem fio; e artigo
Inventor: EMILY QI
IPC: H04W8/00
Filed: 2010-04-07
Abstract: canal de descoberta e sinalizador de descoberta para dispositivos ponto-a-ponto em rede de comunicação sem fio. em um ambiente de comunicação sem fio multicanal, pelo menos um dos canais pode ser usado para a finalidade de permitir que dispositivos descubram uns aos outros de modo que eles possam se comunicar subsequentemente uns com os outros em um outro canal. em algumas modalidades, um sinalizador de descoberta especial pode ser usado naquele canal, que é dedicado para a finalidade de permitir que dispositivos descubram uns aos outros.
Patent BR-PI1104487-B1 (BR)
Title: torneira misturadora com filtro
Inventor: LUIZ MOQUIUTI MORALES
IPC: B01D35/153
Filed: 2011-09-26
Abstract: TORNEIRA MISTURADORA COM FILTRO. A torneira compreende um corpo (10) tendo entradas de água fria (11) e de água quente (12) e uma saída de água de serviço (14) e alojando um mecanismo monocomando (20) para bloquear e liberar a comunicação entre as entradas de água fria (11) e ou de água quente (12) com a saída de água de serviço (14); uma coluna tubular (30), acoplada ao corpo (10) e aberta para a saída de água de serviço (14), e sobre a qual é montado um primeiro cabeçote (40) que carrega uma bica radial de serviço (41), conectada à saída de água de serviço (14); um cartucho de filtro (50) montado no interior da coluna tubular (30), inferiormente conectado à entrada de água fria (11) e sobre o qual é montado um segundo cabeçote (60) que carrega uma bica radial de filtrado (61), conectada ao bocal de saída (52) do cartucho de filtro (50); e um registro de filtrado (70) para bloquear e liberar a comunicação fluida entre a entrada de água fria (11) e a bica radial de filtrado (61).
Patent EA-001001-B1 (EA)
Title: Peptide derivatives
Inventor: SAKURADA SHINOBU
IPC: C07K5/02
Filed: 1996-09-10
Abstract: 1. A compound represented by the following formula: HN=C(R<1>)-X-Y-NH-CH(R<2>)-CO-Q wherein:  R<1> represents C1-6-alkyl group;  R<2> represents an aryl-substituted C1-6-alkyl group (preferably, phenyl-substituted methyl); X represents L-tyrosine (L-Tyr); Y represents at least one of the following amino-acids: D-lysine, 2-amino-4-methylsulphynylbutyrous acid (=AMSB or MetO), 2-amino-3-guanidinpropionic acid (=AGPR), citrulline, D-glutamine and D-ornithine; and Q represents NR<10>-C(R<11>)(R<12>)(R<13>), wherein R<10> represents C1-6-alkyl group (preferably, methyl), R<11> represents carboxy-C1-6-alkyl group, R<12> represents hydrogen atom and R<13> represents hydrogen atom, or the salt thereof. 2. The compound or the salt thereof according to claim 1, wherein R<1> is methyl group. 3. The compound or the salt thereof according to claim 1, wherein R<2> is unsubstituted benzyl group (phenyl-substituted methyl). 4. The compound or the salt thereof according to claim 1, wherein R<10> is methyl group. 5. The compound or the salt thereof according to claim 1, wherein R<11> is carboxymethyl group. 6. The compound or the salt thereof according to claim 1, wherein Y is D-lysine. 7. The compound or the salt thereof according to claim 1, wherein Y is 2-amino-4-methylsulphynylbutyrous acid. 8. The compound or the salt thereof according to claim 1, wherein Y is 2-amino-3-guanidinpropionic acid. 9. The compound or the salt thereof according to claim 1, wherein Y is citrulline. 10. The compound or the salt thereof according to claim 1, wherein Y is D-glutamine. 11. The compound or the salt thereof according to claim 1, wherein Y is D-ornithine. 12. The salt of the compound according to any of claims 1-11, is hydrochloride or acetate. 13. A medicament comprising the compound or the salt thereof according to any of claims 1-12. 14. An anaesthetic pharmaceutical composition comprising as an active ingredient the compound or the salt thereof according to any of claims 1-12.  15. Use of the compound or the salt thereof according to any of claims 1-12 for the manufacture of the anaesthetic pharmaceutical composition according to claim 14. 16. A method for prevention and/or therapeutic treatment of pain which comprises a step of administering to a mammal an effective amount of the compound or the salt thereof according to any of claims 1-12.
Patent EA-004899-B1 (EA)
Title: Method of radiation treatment
Inventor: LARSEN ROY H
IPC: A61K51/00
Filed: 2001-07-04
Abstract: 1. In a method of radiation treatment of a human or non-human mammalian subject which comprises administering to said subject a therapeutically, prophylactically or pain-palliating amount of a bone-targeting complex of a radionuclide, the improvement comprising using as said radionuclide a radionuclide selected from the group consisting of alpha-particle emitting thorium radionuclides. 2. A method as claimed in claim 1 wherein said complex is administered parenterally by injection or infusion. 3. A method as claimed in either of claims 1 and 2 wherein said radionuclide is or thorium-227. 4. A method as claimed in any one of claims 1 to 3 wherein said complex is a complex of said radionuclide and a phosphonate complexing agent. 5. A method as claimed in any one of claims 1 to 3 wherein said complex is a complex of said radionuclide and a polyphosphonate complexing agent. 6. A method as claimed in any one of claims 1 to 5 being a method of therapeutic treatment and/or pain palliation of diseases affecting bones and/or soft tissue. 7. The use of an alpha particle emitting thorium radionuclide, or a bone-targeting complex thereof, for the manufacture of a medicament for use in a method of radiation treatment of a human or non-human mammalian subject which comprises administering to said subject a bone-targeting complex of said radionuclide. 8. Use as claimed in claim 7 wherein said radionuclide is thorium-227. 9. Use as claimed in either of claims 7 and 8 wherein said complex is a bisphosphonate or polyphosphonate complex. 10. Use as claimed in any one of claims 7 to 9 wherein said method is a method of therapeutic treatment and/or pain palliation of diseases affecting bones and/or soft tissue. 11. A radiopharmaceutical composition comprising a bone-targeting complex of a radionuclide selected from alpha-particle emitting thorium radionuclides, together with at least one physiologically acceptable carrier or excipient. 12. A composition as claimed in claim 11 wherein said radionuclide is thorium-227. 13. A composition as claimed in either of claims 11 and 12 wherein said complex is a bisphosphonate or polyphosphonate complex. 14. A bone-targeting complex of a radionuclide selected from alpha-particle emitting thorium radionuclides. 15. A complex as claimed in claim 14 of thorium-227 and bisphosphonate or polyphosphonate complex. 16. A kit for the treatment of bone surfaces or primary and/or metastatic cancers to the skeleton, comprising: an alpha-particle emitting thorium radioisotope, and a bone seeking chelator, for the preparation of physiologically compatible solutions of a thorium radioisotope chelate; a pharmaceutically acceptable carrier; and, optionally, administration equipment.
Patent EA-005494-B1 (EA)
Title: Ibuprofen solutions for capsule- filling and capsule preparations
Inventor: KATO SOICHIRO
IPC: A61K45/06
Filed: 2001-08-23
Abstract: Capsule preparations are produced by using solutions for capsule-filling which contain ibuprofen, polyethylene glycol, water and terpenes (menthol, limonene, borneol, dl-camphor, mentha oil, etc.) optionally together with one or more drugs selected from among antipyretic analgesics, antihistamines, antitussives, expectorants, sympathetic stimulant, analeptics, hypnotic sedatives and anti-inflammatory agents, solubilizers, thickeners, pH controlling agents, colorants, etc. Thus, it is attempted to relieve the bitterness of ibuprofen and establish an immediate action at the same time.
Patent EA-008275-B1 (EA)
Title: Method for energy transformation and a jet engine therefor
Inventor: KONDRASHOV BORIS MIKHAILOVICH
IPC: F02C3/32
Filed: 2002-07-17
Abstract: USE: to transform atmospheric energy and low-grade heat of environmental thermal energy sources, for example water of natural water reservoirs into mechanical work, high-grade heat and "cold".ESSENCE: a method of transformation of potential and heat energy of a working medium into kinetic energy of a pulsed active jet is carried out in a jet device which together with a coupling device performs the function of an ejector-type nozzle apparatus. Said pulse jet enters the coupling device and produces vacuum behind pulse masse, thereby producing an unbalanced pressure force of an external gas masse which initiates the inflow of additional masse of gas which follows each pulse, its further expansion and acceleration with simultaneous temperature drop and addition to the active jet, the thus obtained reactive masse is used for producing a moment of rotation on the shaft of the rotor of a jet engine (Fig.1), in particular cases to obtain the required angular velocity and moment, the value and thermodynamic parameters of joined reactive mass are changed due to connection to the designed number of jet devices having the required parameters for the given operation mode and adding devices of working medium sources for forming active jets and/or due to the change of impulse frequency of the active jets, wherein the kinetic energy, remained after the creation of moment of rotation, is utilized, and the conversion of atmospheric energy in the process of successive adding for generating power is carried out due to the energy obtained thereafter its conversion, wherein the heat generated during air compression in a compressor is utilized and simultaneously reduce its temperature proportionally to acceleration of joined air-reactive mass and use as addition mass of successive cycles for further temperature reduction in a cooling loop. Besides, power generation, high-grade heat and “cold” are carried out in a closed cycle with outer heat supply, wherein after creation of moment of rotation, the joined mass is directed to the coupling device of another nozzle apparatus as addition masses for further temperature reduction and increase the temperature potential difference prior to heating in a heat-exchange device, and utilized kinetic energy of joined reactive mass is used during compression of the used joined mass for increasing pressure potential difference in the process of successive adding when creating a joined reactive mass of successive cycles, wherein the thermodynamic parameters thereof and aggregative state are changed depending upon the initial thermodynamic parameters of low-grade heat and amount of withdrawing heat.
Patent EA-014103-B1 (EA)
Title: Conjugate comprising protein and polymer or derivative thereof (variants), method of producing conjugate and pharmaceutical composition comprising thereof
Inventor: EICHER WOLFRAM
IPC: A61K47/48
Filed: 2005-03-11
Abstract: The present invention relates to conjugates of hydroxyalkyl starch and a protein wherein these conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. The present invention also relates to the method of producing these conjugates and the use of these conjugates.
Patent EA-010193-B1 (EA)
Title: Variable density drilling mud
Inventor: POLIZZOTTI RICHARD S
IPC: C09K8/02
Filed: 2005-06-09
Abstract: One embodiment of the invention is a variable density drilling mud comprising compressible particulate material in the drilling mud wherein the density of the drilling mud changes in response to pressure changes at depth. A second embodiment is a method for varying drilling mud density. The method comprises estimating the pore pressure and fracture gradient, and choosing a drilling mud with compressible materials wherein the effective mud weight of the drilling mud remains between the pore pressure and the fracture gradient in at least one interval of the well bore. A third embodiment is an apparatus for drilling a wellbore.
Patent EA-009445-B1 (EA)
Title: Cap orientation feeding device on bottle neck
Inventor: SASIN PAVEL PAVLOVICH
IPC: B65G27/02
Filed: 2006-12-11
Abstract: Cap orientation feeding device on the neck of the bottle includes a loading tank and a vibrobunker placed underneath, inside the shell there is a spiral tray with the cap orientation device, as well as an isolated chute for cap reception from the spiral tray through the air gap and an overlaid head at the outlet of the chute.The new feature of the device is that, the vibrobunker shell is executed in the way of truncated cone-shaped form with the turned base up, and the spiral tray – in the form of inclined line at an angleregarding the horizontal plane to the shell side of the load-carrying plate taking into consideration the augmentation of coil diameter bottom-up, the possibility of evading multistage jam between them and cap seizure, provision of their firm order; the spiral tray is provided with the tubular knee at the exit of the shell with rectangular cross-section, rotation angle, smooth bends, with the possibility of free cap movement through its internal cavity, provision of the shorted trajectory and its further relocation and necessary spatial fixed order, convenient for cap applying on the neck of the bottle; cap oriented device includes: cap pusher above the low stage, discarding mechanism of the wrong positioned caps, upside-down, on the low stage and breaker of tightened caps allocated in the discarding mechanism, consistently positioned on the upper coil of the spiral tray in front of the tubular knee; a chute contains an upwards expanding catcher, at the same time chute is made of longitudinal and lateral covering bars, taking into account the continuation of tubular knee direction and the possibility to provide the review of the cap transference due to the shortened trajectory; overlapping head is made in the form of rectangular tubular tip of the chute with the semicircular open gain at the bottom on the lower side with a radius of R1, more than the internal radius R2 of the lid, but less than the external radius R3, by left and right front lever holders, hinge fixed on the appropriate sidewalls connected between each other by the retractive spring with the minimum exertion, sufficient for the light snatching of the cap half retained and pulled out and applying angularly on the neck of the bottle passing by, at the same time the imposing head is additionally provided with the horizontal ski, executed by the way of the top wall continuation with the ability to adjust and apply a cap in the position convenient for the closure.The suggested device is compact, structurally unsophisticated, low cost in manufacturing, user friendly, with a wide functional and processing capabilities, high accuracy and operating efficiency.
Patent EA-012658-B1 (EA)
Title: Method for converting wind stream energy into rotational movement using fluid medium energy and a propulsion device for carrying out said method
Inventor: SKOROKHOD ALEXANDER PANTELEYMO
IPC: F03D7/00
Filed: 2006-03-09
Abstract: The set of inventions relates to methods for converting wind stream energy into a rotational movement and to propulsion devices for carrying out said methods. Said invention is aimed at enhancing conversion efficiency using fluid medium energy. The method for converting a fluid medium energy into a rotation movement consists in producing a fluid medium action on at least one blade which is cantileverly arranged with respect to the axis of rotation thereof for generating the cantilever rotation movement hingedly connected to a power shaft. A propulsion device for converting a fluid medium energy into a rotation movement comprises: at least one blade provided with a flexible rear section, connected by the cantilever with a joint; the cantilever oscillation drive mounted on a platform rotatably to a base; the power shaft arranged in a perpendicular position with respect to the cantilever oscillation movement and connected with the cantilever by a joint.
Patent EA-013375-B1 (EA)
Title: MODULATION OF IMMUNOSTIMULATORY PROPERTIES OF SHORT INTERFERING RIBONUCLEIC ACID (siRNA) BY NUCLEOTIDE MODIFICATION
Inventor: ULHMANN EUGEN
IPC: C12N15/11
Filed: 2006-09-15
Abstract: Double-stranded short interfering ribonucleic acid (siRNA) are modified to reduce or eliminate their immunostimulatory effect without significantly affecting their gene silencing effect. Modified siRNA include one or more 2' sugar modifications and, optionally, internucleotide linkages on the sense strand. Compositions containing the modified siRNA and methods of making and using the modified siRNA are disclosed. New and previously characterized siRNA can be synthesized to incorporate modifications according to the invention.
Patent EA-018187-B1 (EA)
Title: Trisubstituted pyrazoles as acetylcholine receptor modulators
Inventor: THURING JOHANNES WILHELMUS JOHN F
IPC: A61K31/455
Filed: 2009-05-08
Abstract: The present invention relates to 1-alkyl-3-aniline-5-arylpyrazole derivatives according to Formula (I) and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
Patent EA-018937-B1 (EA)
Title: Hair care method
Inventor: AVERY ANDREW RICHARD
IPC: A61K8/60
Filed: 2009-05-20
Abstract: A method of treating hair comprising the step of applying to dry towel dried hair a hair care product comprising sucrose acetate isobutyrate and silicone.
Patent EA-021445-B1 (EA)
Title: Adhesive skirting board
Inventor: PLENET JEAN-MARIE
IPC: E04F19/02
Filed: 2011-03-11
Abstract: The present invention relates to a board element (5) formed by a lengthened section, comprising at an inner surface two adhesive bands extending longitudinally, wherein each first band is adhesive on its face opposite to the lengthened section and obtained by longitudinal folding of the sheet (6), and the other band is stuck to the lengthened section.
Patent EA-032206-B1 (EA)
Title: Method for separating a drag reducing polymer from a low molecular weight liquid
Inventor: JOHNSTON RAY L
IPC: F17D1/16
Filed: 2009-12-09
Abstract: A method for drag reducing low molecular weight liquids is provided. More specifically, a method to separate drag reducers from low molecular weight liquids, such as hydrocarbons and anhydrous ammonia, is provided, comprising the steps of: (a) introducing a drag reducing polymer into said low molecular weight fluid; (b) partially vaporizing said mixture comprising a low molecular weight fluid and a drag reducing polymer in a vaporization vessel at a vaporization temperature; and (c) recovering said low molecular weight vapor, wherein said drag reducing polymer is a high molecular weight polymer having a weight average molecular weight greater than about 4 million and is selected from the group consisting of alpha-olefin polymers, acrylamide polymers, acrylamide acrylic acid copolymers and salts thereof, acrylic esters and methacrylic esters.
Patent EA-020769-B1 (EA)
Title: Method for diagnosis of cardiovascular diseases
Inventor: NEMKOVICH NIKOLAJ ALEXEEVICH
IPC: G01N21/64
Filed: 2012-02-01
Abstract: The invention relates to a biomedical optics and touches upon the problem of expressive highly-sensitive diagnosis of cardiovascular diseases. The invention is aimed at enhancement of accuracy diagnosis of cardiovascular diseases. The assigned purpose is characterized in that according to the method for diagnosis of cardiovascular diseases based on optical excitation of fluorescent probes in membranes of erythrocytes, registration of the fluorescent probes characteristics and comparison of said characteristics for sick and healthy persons, fluorescent probes with intramolecular proton transfer having dual luminescence are used, duration of excitation pulse is selected less than life time of the probe excited state, fluorescent instantaneous spectrum after a row of time interval are registered and by relation of intensities of two maximums of fluorescent instantaneous spectrums of sick and healthy persons a diseases diagnosis is provided. Introduction of the present method in medical practice stipulates to shorten considerably time and economic costs for diagnosis of cardiovascular diseases. Utilization of the method for blood analysis can be successfully applied for diagnosis of other diseases. Besides, the present method permits to determine the rate of each disease.
Patent EA-025015-B1 (EA)
Title: Actuator cap for a fluid dispenser
Inventor: BETTS KASSIE TERRA-LYNN
IPC: B65D83/22
Filed: 2012-10-09
Abstract: An actuator cap (1) for dispensing a liquid product, comprising a rotatable outer body (2) and an associated actuator button (3) and a non-rotatable chassis (4) and an associated spray channel assembly (6), the latter comprising an outlet nozzle (63); the outer body (2) and actuator button (3) being rotatable between a first position in which the actuator button (3) is non-elevated, the actuator button (3) being incapable of depression in this position; a second position in which the actuator button (3) is elevated across its full length and width relative to top surface (25) of the outer body (2), the button (3) still being incapable of depression in this position; and a third position in which the actuator button (3) is elevated across its full length and width and tilted relative to top surface (25) of the outer body (2), the button (3) being capable of depression in this position; depression of the actuator button (3) causing release of liquid product from an associated container through the spray channel assembly (6).