baber/WOPTO huggingface dataset:
Patent AP-1587-A (AP)
Title: Azaindoles.
Inventor: COX PAUL JOSEPH
IPC: A61P25/28
Filed: 2000-12-27
Granted: 2006-03-02
Abstract: The invention is directed to compositions containing physiologically active compounds of general formula (I) wherein R1 is aryl or heteroaryl: R2 represent hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, -Z1R8,-C(=O)-NY3Y4,-CO2R8,-NY3Y4,-N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4,-N(R6)-C(=O)-OR7,-N(R6)-SO2-R7,-N(R6)-SO2-NY3Y4 and one or more halogen atoms; R3 represents hydrogen, aryl, cyno, halo, heteroaryl, lower alkyl,-C(=O)-OR5 or -C(=O)-NY3Y; and X1 represents N.CH. C-halo, C-CN,C-R7,C-NY3Y4,C-OH, C-Z2R7, C-C(=O)-OR5, C-C(=O)-NY3Y4, C-N(R8)-C(=0)-R7,C-SO2-NY3Y4,C-N(R8)-SO2-R7,C-alkenyl or C-NO2; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit protein kinases.
Patent DO-P2006000169-A (DO)
Title: Inhibidores espiropiperidina de beta-secretasa para el tratamiento de la enfermedad de alzheimer
Inventor: COBURN CRAIG A
IPC: A61K31/438
Filed: 2006-07-17
Abstract: La presente invención estd dirigida a compuestos de espiropiperidina de fórmula (I) y tautómeros de los mismos, que son inhibidores de la enzima beta-secretasa y que son útiles en el tratamiento de enfermedades en las que estd implicada la enzima beta-secretasa, tales como la enfermedad de Alzheimer. La invención estd tambión dirigida a composiciones farmaceuticas que comprenden estos compuestos y al use de estos compuestos y composiciones en el tratamiento de enfermedades en las que estd implicada la enzima beta-secretasa.
Patent DO-P2016000174-A (DO)
Title: Composición herbicida que contiene ácido 4-amino-3-cloro-6-(4-cloro-2-fluoro-3-metoxifenil) piridin-2-carboxílico o sus derivados, fluroxipir o sus derivados y fenoxiauxinas o sus derivados
Inventor: DEGENHARDT RORY
IPC: A01N43/40
Filed: 2016-07-12
Abstract: Se proveen en la presente composiciones herbicidas que comprenden una mezcla que pose (a) ácido 4-amino-3-cloro-6-(4-cloro-2-fluoro-3-metoxifenil)piridin-2-carboxílico o una de sus sales, ésteres o amidas aceptables en la agricultura, (b) fluroxipir o una de sus sales, ésteres o amidas aceptables en la agricultura, y (c) MCPA o 2,4-D o una de sus sales, ésteres o amidas aceptables en la agricultura. Las composiciones proveen un control sinérgico de malezas de la vegetación no deseable en zonas que incluyen, en forma no taxativa, cereales, en zonas de praderas y pasturas, manejo de la vegetación industrial (IVM), y derechos de paso.
Patent DO-P2019000307-A (DO)
Title: Una composición de nanoemulsión de clobetasol de aceite en agua
Inventor: JAVIER SANAGUSTIN AQUILUE
IPC: A61K47/34
Filed: 2019-12-05
Abstract: Se refiere a una nanoemulsión de aceite en agua que tiene una fase acuosa continua y gotas de aceite dispersas, donde la nanoemulsión comprende: (a) clobetasol; (b) uno o más componentes oleosos; y (c) uno o más tensioactivos; junto con uno o más excipientes o vehículos donde: la osmolalidad de la nanoemulsión es desde 100 hasta 500 mOsm/kg; el tamaño promedio de gota es desde 1 hasta 500 nm; la relación en peso entre los componentes oleosos y la suma de los componentes oleosos y uno o más tensioactivos es desde 0,001 hasta 0,5; la relación en peso entre el componente oleoso y el clobetasol es desde 1:1 hasta 200:1; y la relación en peso entre el tensioactivo y el clobetasol es desde 2:1 hasta 200:1. También se refiere a procedimientos para su preparación, a su uso como medicamento y para la profilaxis y/o tratamiento de la inflamación.
Patent DO-P2020000236-A (DO)
Title: Anticuerpos il-1 1ra
Inventor: Stuart Alexander Cook
IPC: C07K16/28
Filed: 2020-12-04
Abstract: Se proporcionan moléculas de unión a antígeno capaces de unirse a IL-11Ra, y métodos de tratamiento médico y profilaxis que usan las mismas.
Patent DO-P2023000130-A (DO)
Title: ANTICUERPOS MULTIESPECÍFICOS QUE TIENEN ESPECIFICIDAD PARA IL-4R e IL-31
Inventor: JULIO TIETZ
IPC: A61K39/395
Filed: 2023-06-23
Abstract: La presente invención se refiere a un anticuerpo multiespecífico que comprende uno o dos dominios de unión, que se unen específicamente a IL-4R (IL4R-BDs), y uno o dos dominios de unión, que se unen específicamente a IL-31 (IL31-BDs), en el cual el anticuerpo multiespecífico comprende una región Fc de inmunoglobulina. La presente invención también se refiere a ácidos nucleicos que codifican para dicho anticuerpo multiespecífico, vector(es) que comprende(n) dichos ácidos nucleicos, célula(s) hospedera(s) que comprende(n) dichos ácidos nucleicos o dicho(s) vector(es), y a un método para producir dicho anticuerpo multiespecífico. De manera adicional, la presente invención se refiere a composiciones farmacéuticas que comprenden dicho anticuerpo multiespecífico y a métodos de uso de las mismas.
Patent EC-SP12011785-A (EC)
Title: Composición de agente tensoactivo estructurada con ión de metal de tierra alcalina y microfibra de celulosa
Inventor: D AMBROGIO ROBERT
IPC: C11D17/00
Filed: 2012-04-05
Abstract: Una composición acuosa que comprende por lo menos un agente tensoactivo; un agente de suspensión que comprende microfibra de celulosa; de 10 a 600 ppm de un ión de metal de tierra alcalina y agua. La composición se puede utilizar para estructurar los sistemas de agentes tensoactivos para la suspensión del material en la composición.
Patent EE-200200706-A (EE)
Inventor: SIEMEISTER GERHARD
IPC: C07K16/22
Filed: 2001-06-20
Abstract: The present invention describes the combination of substances interfering with the biological activity of Vascular Endothelial Growth Factor (VEGF)/VEGF receptor systems (compound I) and substances interfering with the biological function of Angiopoietin/Tie receptor systems (compound II) for inhibition of vascularization and for cancer treatment. <IMAGE>
Patent EG-26062-A (EG)
Title: Surfactant concentrate
Inventor: COURCHAY FLORENCE CATHERINE
IPC: C11D3/20
Filed: 2010-11-28
Granted: 2013-01-20
Abstract: The present relates to a surfactant concentrate comprising at least 75% of an essentially completely neutralized anionic sulphated surfactant and 5% to 25% carboxylic acid, of which 4 % to 96% of the carboxylic acid is in its free acid form, the process for making it and a detergent composition containing it.
Patent GB-189700164-A (GB)
Title: Roller Bearings.
Inventor: LOUD HERBERT
Filed: 1897-01-04
Granted: 1897-02-06
Abstract: 164. Loud, H. Jan. 4. Roller bearings for pulley sheaves are made readily removable for repair. An annular case divided laterally into two parts a, a<2>, Fig. 1, has an internal rib a<3>, to prevent lateral motion of the necked rollers c, Fig. 3. The rollers are kept apart by a guide-piece d, Fig. 6, with recesses d<2> in which the necks rest, and an aperture d' slightly larger than the shaft. After the rollers have been placed in the portions of the case, the latter, which are provided with interlocking tongues to maintain their correct relative positions, are placed together and driven into the block. The case is prevented from turning by lugs b. The case may be made in one piece, and the internal rib in two removable parts.
Patent GB-189702458-A (GB)
Title: Improvements in or connected with Stop Vavles.
Inventor: PERTWEE HERBERT ARTHUR
Filed: 1897-01-29
Granted: 1898-01-08
Abstract: 2458. Pertwee, H. A. Jan. 29. Steam separators.- The casing a of a stop valve is elongated for the reception of a steam separator consisting of a hollow cylinder g fitted into the aperture below the lift valve e. The cylinder is provided on its exterior with helical blades h, which impart to the steam a rotary motion, whereby particles of water carried by it are driven to the side of the casing, down which they trickle and thence pass through openings n in a curved guideplate n<1> into a steam trap below. The helical blade i inside the cylinder g counteracts the rotary motion of the steam before it passes to the outlet c,
Patent GB-189702475-A (GB)
Title: Improvements in Fasteners for use when Securing or Sealing Envelopes, or Binding Papers or Documents together, and like Purposes.
Inventor: CLARKE ARTHUR SAMUEL
Filed: 1897-01-30
Granted: 1897-11-20
Abstract: 2475. Clarke, A. S. Jan. 30. Paper fasteners; envelopes.-Relates to a fastener for closing envelopes or for securing papers together. The part d, Fig. 3, is secured to the body of the envelope by means of the legs f. The part b, Fig. 6, is secured to the closing-flap so that, when the envelope is closed, the pin c passes through the opening in the part d, where it is held by the tongues e.
Patent GB-189706929-A (GB)
Title: Improvements in Apparatus for Electrolysing Sodium Chloride or other Salts.
Inventor: TAYLOR FRANK
Filed: 1897-03-17
Granted: 1898-03-05
Abstract: 6929. Taylor, F., Cooke, A., and Montgomery, B. W. D. March 17. Chlorine.-Relates to apparatus for electrolysing sodium-chloride or other solutions, and for absorbing the evolved chlorine. The vat a contains a number of iron sheets or cathodes b, alternating with vertical rows of carbon rods or anodes c. E a c h an ode or cathode is supported in a framing b<1>, which also supports on each side of the electrode glass or other strips d arranged louvre fashion. The upper part of each anode has an inverted trough c' to collect the evolved chlorine, and direct it through tubes e', e. To prevent polarization, air may be injected below each anode, or the electrolyte can be kept agitated by injecting it in an intermittent or pulsating manner. The evolved chlorine is absorbed in a vessel g, charged with water and lime or magnesia, the gas entering from the tube e to a rotating tube g<1> provided with hollow distributing-arms g<3>.
Patent GB-189707507-A (GB)
Title: Improvements in Liquid Pressure Engines.
Inventor: STUMPF JOHANN
Filed: 1897-03-23
Granted: 1897-05-15
Abstract: 7507. Stumpf, J. March 23. Water-pressure engines.-The valves are arranged to open in the opposite direction to the flow of the liquid, and are closed just before the end of the stroke so that the momentum of the piston tends to produce a vacuum behind the latter and an excess of pressure before it, which assists the exhaust and admission valves respectively to open. Fig. 2 shows a section through a double-acting engine with the inlet valves below and the exhaust above. All the valves are worked from a single rod t<7> through bell-crank levers and tappets h<1>, h<3>.
Patent GB-189709982-A (GB)
Title: Improvements in or connected with Pneumatic Tyres.
Inventor: TIPPET HENRY GRENDON
Filed: 1897-04-21
Granted: 1898-03-26
Abstract: 9982. Tippet, H. G., and Hewitt, J. April 21. Tyres, pneumatic.-A lining for the outer cover is formed so as to be circumferentially elastic and transversely inelastic. This may be done either by using rubber threads in one direction and inelastic threads in the other, or by embedding transverse inelastic threads in rubber or between sheets of rubber, or by weaving with a loose weft and tight warp or in a similar manner. Preferably only the tread part E is formed in this manner, the edges B being inextensible in each direction.
Patent GB-189710420-A (GB)
Title: Improvements in Bedstead Bottoms and Mattresses.
Inventor: BILLINGTON GEORGE ALFRED
Filed: 1897-04-27
Granted: 1898-03-26
Abstract: 10,420. Billington, G. A. April 27. Bedsteads; mattresses.-The fabric a is attached to the end bars of a bedstead bottom or mattress frame by plates or bars b, which are serrated or toothed to take into the fabric and are bent or hooked over the angle bars c. These plates or bars b may themselves form the end of the fabric, as in Fig. 4, and be connected to the angle bars c by tension bolts. In such a case, the part b<1> is bent more sharply where the hook nut of the bolt engages.
Patent GB-189714099-A (GB)
Title: Improvements in or relating to Self-acting Mules.
Inventor: RIEHL ALFRED
Filed: 1897-06-09
Granted: 1897-10-30
Abstract: 14,099. Richl, A. June 9. Mules. - Broken threads which have become doubled together are broken by hooks d, which are mounted between the threads upon a wire g carried by spring arms a<1>. Normally the hooks are clear of the threads, but as the carriage approaches the roller beam, they are depressed by reason of an incline h on the carriage engaging with the rod a. Upon the counterfaller wire f is fitted a block A, in which are inclined slots for the threads, so that a tension is put upon the threads and they are automatically cleared of loose fibres.
Patent GB-189716548-A (GB)
Title: Combined Prism Pavement and Side Prism Plate for Illuminating Basements.
Inventor: EWEN JOHN MEIGGS
Filed: 1897-07-13
Granted: 1897-08-21
Abstract: 16,548. Ewen, J. M. July 13. Pavement-lights.-The prismatic pavement-lights J are arranged to direct some of the rays of light on to vertical prismatic side lights or reflectors H, H<1> which refract or reflect the rays into the basement or room.
Patent GB-189721464-A (GB)
Title: An Improved Device for Producing and Burning Acetylene Gas.
Inventor: LLER JUSTUS WINDM
Filed: 1897-09-18
Granted: 1897-10-30
Abstract: 21,464. Windm³ller, J. Sept. 18. Acetylene and like lamps; velocipede lamps.- A cycle lamp is formed with an open air-space l<1> between the top plate s and the casing l, and the burner f carried by the bridge f, projects only partly into the casing.
Patent GB-189730580-A (GB)
Title: Improvements in or connected with the Chain Wheel Adjustment of Cycles.
Inventor: WILSON EDWARD
Filed: 1897-12-28
Granted: 1898-11-05
Abstract: 30,580. Wilson, E., and Moore, H. H. Dec. 28. Chains, adjusting tension of. - The rear fork end 11 is slotted to receive a piece 14 shown separately in Fig. 5, having lugs 15 which fit into sockets 13 in the fork end and prevent the piece 14 from sliding longitudinally. The axle 20 is formed with flats which slide in a screw-threaded slot 16 in the piece 14, and is secured by nuts 21 to a plate 18 having flanges 23 and 26. These flanges engage grooves 24 and 25 formed on a bolt 17 which screws into the screw-threaded slot 16. On turning the bolt 17, the plate 18 carrying the axle is moved longitudinally.
Patent GB-189804081-A (GB)
Title: Improvements in Fire-guards and applicable to other analogous purposes.
Inventor: COOPER LEWIS
Filed: 1898-02-18
Granted: 1898-12-23
Abstract: 4081. Cooper, L., and Sharman, R. G. Feb. 18. Fire-guards; fenders.-To an angle-iron secured within the fender b are attached the lower ends of lazy-tongs c, their upper ends being secured to the rail d. To retain the guard so formed in the raised position, the bars e, g, f are pivoted to the crossing-points of the lazy-tongs, and rule-jointed rods h are pivoted to the bars e and f, so as to assume a vertical or nearly-vertical position when the guard is raised. To lock the bars h in this position, a set-screw l, Fig. 3, is provided, passing through the axis of the rule-joint and pressing against the bar g, on which the runner j slides. The guard is applicable for fencing off machinery &c.
Patent GB-189807970-A (GB)
Title: Improvements in Rotary Engines.
Inventor: DORAU JOHN PAUL
Filed: 1898-04-04
Granted: 1898-08-27
Abstract: 7970. Dorau, J. P. April 4. Centrifugal governors for rotary-engine valve gear. In the form of rotary engine illustrated, the centrifugal governor, which is driven directly from the shaft of the rotary piston by the bevel gearing 53, depresses a rod 64 when the normal speed is exceeded, and, through the lever 45, the segmental rack 46, and the pawl 47, actuates the lever 44 of the valve spindle 43 to vary the supply of steam. In a more complicated engine, in which the piston and the main shaft are fixed, the governor is driven from the rotary casing, and the rod 64 actuates a bell-crank lever, which engages with one or other of the two valve levers controlling the interchangeable inlet and exhaust ports in the fixed piston. In a further modification, teeth formed on a lever pivoted to the lower end of the rod 64 engage with the end of the rod carrying the segmental rack.
Patent GB-189810977-A (GB)
Title: Improvements in Tubes for Heating or for Interchange of Temperatures, and in Apparatus for Making the same.
Inventor: MARIN EUGENE
Filed: 1898-05-13
Granted: 1898-08-06
Abstract: 10,977. Marin, E. May 13. Metal tubes.-Tubes for steam generators, or for heating or cooling apparatus, are made with one or more longitudinal corrugations, which may extend to the ends. The tube has no sharp angles, so as to facilitate cleaning. One form is shown in Fig. 2. Fig. 5 shows an apparatus for producing such tubes. They are drawn on a mandrel M through a die, the corrugation being made by a tool P which is urged forwards by hydraulic pressure.
Patent GB-189813782-A (GB)
Title: Improvements in Bottles to Prevent the Fraudulent Refilling thereof.
Inventor: POOLE JOHN HENRY
Filed: 1898-06-21
Granted: 1898-08-13
Abstract: 13,782. Poole, J. H. June 21. Stoppers; refilling, preventing.-A plug c, formed with a central passage c', a seat c<2> for the ball valve e, and a cylindrical guard c<3> for the valve, is inserted in the bottle neck, a n d above it is introduced a larger ball f. Above the valve is inserted a casing g<1> formed with stops g for the ball f and with grooves g<2> for the passage of the liquid. The ball f serves to prevent tampering with the valve by deflecting a wire introduced for that purpose into the annular recess d. The guard c<3> is formed with outlet ports c<4>, and with a projecting rim c<5> to prevent the introduction of a wire through the ports. The plug c and casing g<1> are cemented &c. in the neck, and they may be suitably connected together instead of being made separately. When the bottle is inverted, the ball f and valve e are displaced so as to permit the outflow of the liquid, but when the bottle is upright the valve e rests on its seat and prevents refilling. When the bottle is horizontal, the valve is held by the ball f in position to block the ports c<4>.
Patent GB-189814257-A (GB)
Title: Refrigerating Machine.
Inventor: ALLEN FRANK
Filed: 1898-06-28
Granted: 1898-09-03
Abstract: 14,257. Allen, F. June 28. Ice-making and refrigerating.-Relates to ammonia absorption machines. The ammonia gas from the steam-heated generator A is cooled successively in the interchanger coils B, spray-cooled coils C, and coils in a box D, which contains coils through which expanded gas from the evaporator E passes. Liquefied gas is stored in the vessel J. Weak ammonia liquor is cooled by passing successively through the interchanger coil I, coil in the water tank F<1>, spray-cooled coil F, and coil in the box D, .whence it flows to the absorber H. Strong liquor is drawn off from the absorber by a pump P, and is heated by successively passing it through the interchanger coils B, I and through coils M which are heated by exhaust steam from the pumps and coils in the generator. Vessels L placed in the pipe leading from the absorber to the pump are connected by a bye-pass l<1> which allows any gas to return.
Patent GB-189815947-A (GB)
Title: Improvements in the Manufacture of Sulphuric Anhydride.
Inventor: JOHNSON JAMES YATE
Filed: 1898-07-21
Granted: 1899-07-21
Abstract: 15,947. Johnson, J. Y., [Badische Anilin & Soda Fabrik]. July 21. Sulphuric anhydride.- Consists of three improvements in the manufacture of sulphuric anhydride by the contact process, viz., (1) purifying the gases to be treated, (2) passing the gases through the contact substance at a regulated temperature, and (3) arranging the contact substance so as to avoid undue rise of pressure. Arsenic, phosphorus, mercury, sulphuric acid, sulphur, and dust of any kind are the principal impurities to be eliminated from the gases, and are separated by treating the gases while hot with a jet of steam, with or without air or other gas, then gradually cooling, afterwards repeatedly washing, and finally drying by means of sulphuric acid. The gases, before being allowed to pass to the contact substance, must be optically free from dust and mist, and chemically free from arsenic, phosphorus, mercury, and their compounds. It is necessary to regulate the temperature during the passage of the purified gases over the contact substance, namely, platinized asbestos, as one effect of the reaction is to raise the temperature of such contact substance, which may even reach bright red heat, at which temperature some of the formed sulphuric anhydride reverts to sulphurous anhydride and oxygen. Several devices for regulating the temperature are illustrated and described. In the simple form shown in Fig. 1, a brickwork structure or iron tube M has a tube R fixed within it, leaving an annular space between the two. The contact substance is placed in the lower part b of the tube R. The temperature is raised, at the commencement of operations, to the required temperature, by burners h. Cold air is then passed into the annular space through openings n, and carry the heat from the contact substances upwards, heating the upper part of the tube R on its way to the outlet L. Further heat may be imparted by burners h<1>. The purified gases enter the upper end of the tube R, become heated by passing through the part a, and then pass through the contact substance in the part b. Several modifications may be made in the form of apparatus used, the invention not being limited to any particular arrangement. The cooling may, for example, be effected by the gases themselves or by liquid baths, and several tubes may be combined together. To avoid undue pressure in the tubes, the contact material is arranged in thin layers upon perforated discs c, c', c<11>, c<111>, separated from one another and from the base by distance tubes b, d, d', d<11>. By this or some corresponding arrangement, the gases can pass through practically at atmospheric pressure.
Patent GB-189821869-A (GB)
Title: Improvements in Belt Fasteners.
Inventor: MARRIAGE ERNEST
Filed: 1898-10-18
Granted: 1899-04-01
Abstract: 21,869. Marriage, E. Oct. 18. Washers. - Relates to fasteners for driving-bands or belts or for conveyer belts. The turned-up ends d, e of the belt are clamped between plates or washers b, c by screws a, which pass through the plates b and screw into the plates c. The number of screws and plates is suited to the width of the belt. The edges of the plates are rounded off to prevent injury to the belt, and in such a way as to allow them to be used with either side towards the belt.
Patent GB-189824593-A (GB)
Title: Improvements connected with the Lighting of Miners' and other Lamps by Means of an Electric Current.
Filed: 1898-11-22
Granted: 1899-10-28
Abstract: 24,593. Rhodes, O. Y., and Miners' Lamp Electric Lighting Co. Nov. 22. Lighting oil and vapour lamps; miners'safety lamps. -Relates to electric contactmakers for use with miners' safety and other oil and vapour lamps which are ignited by means of electricity, the contact-makers being especially designed for use with the apparatus described in Specifications No. 17,966, A.D. 1887, No. 13,159, A.D. 1889, and No. 3785, A.D. 1893. When using the apparatus, the lead e is secured to one pole or terminal of a battery or its equivalent, and the lamp is placed on the other pole or terminal of the said battery. On pressing the sliding contactpiece a against any portion of the body of the lamp which forms one pole, the contact-piece slides within the casing b and makes contact with and completes the circuit through the terminal d, which is mounted in vulcanite or insulating-material c. On removing the pressure. the contact-piece a is forced out of contact with the terminal d by means of the spring g. In a modification, the contact-piece a is attached to the casing and the terminal d slides to make the contact, a spring being employed to hold the terminal and contact-piece normally apart.