Patent SG-11201807176X-A (SG)
Title: TGFß1-BINDING IMMUNOGLOBULINS AND USE THEREOF
Inventor: SCHURPF THOMAS
IPC: C07K16/22
Filed: 2017-03-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101111101101110011101101111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ..or::,,, 14 September 2017 (14.09.2017) WIP0 I PCT WO 2017/156500 Al (51) International Patent Classification: DO, C07K 16/22 (2006.01) HN, KP, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (21) International Application Number: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, PCT/US2017/021972 NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (22) International Filing Date: RU, 10 March 2017 (10.03.2017) TH, ZA, ZM, ZW. RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, 62/307,353 11 March 2016 (11.03.2016) US TZ, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 62/443,615 6 January 2017 (06.01.2017) US TJ, 62/452,866 31 January 2017 (31.01.2017) US DK, LV, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (71) Applicant: SCHOLAR ROCK, INC. [US/US]; 620 Me- SM, morial Drive, 2nd Floor, Cambridge, MA 02139 (US). GW, KM, ML, MR, NE, SN, TD, TG). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: SCHURPF, Thomas; 18 Cottage Park Avenue, Declarations under Rule 4.17: Cambridge, MA 02140 (US). CARVEN, Gregory J.; 89 — as to applicant's entitlement to apply for and be granted a Brooks Street, Maynard, MA 01754 (US). DATTA, Ab- hishek; 48 Hemman Street, Boston, MA 02131 (US). patent (Rule 4. / 7(ii)) LONG, Kimberly; 620 Memorial Drive, 2nd Floor, Cam- — as to the applicant's entitlement to claim the priority of the bridge, MA 02139 (US). earlier application (Rule 4.17(iii)) Agents: CLARKE, Marcie B et al.; McCarter & English, Published: (74) LLP, 265 Franklin Street, Boston, MA 02110 (US). — with international search report (Art. 21(3)) (81) Designated States (unless otherwise indicated, for every _ before the expiration of the time limit for amending the kind of national protection available): AE, AG, AL, AM, claims and to be republished in the event of receipt of AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, amendments (Rule 48.2(h)) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, Il © © ir) ir) 11 IN 1-1 (54) Title: TGFB1-BINDING IMMUNOGLOBULINS AND USE THEREOF 0 N (57) : Disclosed herein are immunoglobulins, such as antibodies, and antigen binding portions thereof, that specifically en. ) bind complexes of GARP-TGF131, LTBP1-TGF131, LTBP3- TGF131, and/or LRRC33-TGF131 The application also provides methods ,7 1 1 . 9 of use of these immunoglobulins for, for example, inhibiting TGF131activity, and treating subjects suffering from TGF131-related dis - .,- orders, such as cancer and fibrosis.