baber/WOPTO huggingface dataset:
Patent EA-003445-B1 (EA)
Title: Novel polymorphic forms of cipamfylline
Inventor: EGGLESTON DRAKE
IPC: A61P11/06
Filed: 1998-10-23
Abstract: 1. A crystalline polymorph of 1,3-di-cyclopropylmethyl-8-amino xanthine that exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in d spacing (A) in decreasing intensity, at approximately 12.302, 7.702, 8.532, 4.289 and 2.854, and as expressed in Figure 1. 2. A crystalline polymorph of 1,3-di-cyclopropylmethyl-8-amino xanthine that exhibits an infrared absorption spectrum in potassium bromide having characteristic absorption bands expressed in reciprocal centimeters as described in Figure 20. 3. A crystalline polymorph of 1,3-di-cyclopropylmethyl-8-amino xanthine that that exhibits a single crystal X-ray crystallographic analysis with (a) crystal parameters that are approximately equal to the following: Crystal shape (mm) Flat needles Crystal dimensions 1.0 x 0.12 x 0.08 mm Crystal color Colorless Space Group P1 triclinic ( 2 Temperature 295K Cell Constants a = 10.829 (2) angstrom  b = 12.636 (2) angstrom  c = 5.105 (3) angstrom  alpha (alpha) = 99.48 (4)  beta (beta) = 91.53 (4)  gamma (gamma) =83.84 (3) Volume: 685.0 (8) angstrom <3> Molecules/unit cell (Z) 4 Density, (p) g/cm<-3> 1.354 mu 7.362 cm<-1> F (000) 292 and the atomic positions of all atoms relative to the origin of the unit cell as represented in the tables of Figures 12 to 15. 4. A crystalline polymorph of 1,3-di-cyclopropylmethyl-8-amino xanthine that exhibits a Raman Spectroscopy pattern as expressed in Figure 4. 5. A pharmaceutical composition comprising an amount of a polymorph according to any one of Claims 1 to 4, and a pharmaceutically acceptable carrier or diluent. 6. A method of treating a PDE4 mediated disease in a mammal in need thereof, which method comprises administering to said mammal an effective amount of a polymorph according to any one of Claims 1 to 4. 7. A method of treating a TNF mediated disease in a mammal in need thereof, which method comprises administering to said mammal an effective amount of a polymorph according to any one of Claims 1 to 4. 8. A process for producing a crystalline polymorph of 1,3-di-cyclopropylmethyl8-amino xanthine, Form I, which process comprises a) dissolving 1,3-di-cyclopropylmethyl-8-amino xanthine in 1-propanol; and b) cooling the solution to crystalize out of solution the desired polymorphic Form I. 9. The process according to Claim 8 wherein the 1-propanol is admixed with water. 10. The process according to Claim 8 wherein the cooling temperature is from about 0 to about 25 degree C. 11. The process according to Claim 8 wherein the crystalization time is from about 15 to about 120 minutes. 12. The process according to Claim 8 wherein the xanthine is dissolved by heating the 1-propanol to reflux conditions. 13. A process for producing a crystalline polymorph of 1,3-di-cyclopropylmethyl8-amino xanthine, Form I, which process comprises a) dissolving 1,3-di-cyclopropylmethyl-8-amino xanthine in tetrahydrofuran or acetone; and b) cooling the solution to crystalize out of solution the desired polymorphic Form I.
Patent EA-005571-B1 (EA)
Title: System for transporting active substances in a biological system
Inventor: BLUM HELMUT
IPC: A61K9/127
Filed: 2001-03-23
Abstract: The invention relates to a stabilizer-free system for transporting active substances in a biological system, consisting of one or more active substances and magnetic particles. The inventive system is characterized in that the particles are provided with active substances on at least part of their surface. The magnetic particles do not necessarily have to be modified in this system. The system can be incorporated into aqueous and oily suspensions, as well as in microemulsions, oil-in-water emulsions, water-in-oil emulsions and water-in-oil-in-water emulsions.
Patent EA-008972-B1 (EA)
Title: New crystalline forms of clopidogrel hydrobromine and methods of their preparation
Inventor: HAJICEK JOSEF
IPC: C07D495/04
Filed: 2004-12-21
Abstract: The invention concerns clopidogrel hydrobromide in the crystalline Form I characterized by an X-ray diffraction pattern with characteristic interplanar distances d of 4.01; 4.39 and 3.17 Å and which is further characterized by bands in the infrared spectra at 1743; 1421; 1237, 760 and 728 cm. Clopidogrel hydrobromide in the crystalline Form II is characterized by an Xray diffraction pattern with characteristic interplanar distances d of 4.52; 3.83; 3.48 Å, as well as bands in the infrared spectra at 1754; 1436; 1317 and 1223 cm. Crystalline form III is characterized by the following peaks ascertained by X-ray diffraction at 2θ positions: 7.796°; 15.380°; 18.389°; 19.369° and 23.895°. The method of preparation of clopidogrel hydrobromide in the crystalline Form I consist in precipitating the clopidogrel base dissolved in toluene with a concentrated solution of hydrobromic acid. The method of preparation of clopidogrel hydrobromide in the crystalline Form II consist in dissolving the clopidogrel base in an organic solvent and precipitating it with a solution of hydrobromic acid in toluene or with gaseous hydrogen bromide. Form III can be used for the preparation of pharmaceutically applicable Form II.
Patent EA-013790-B1 (EA)
Title: Novel inhibitors of glutaminyl cyclase
Inventor: SCHILLING STEPHAN
IPC: A61K31/4164
Filed: 2005-02-04
Abstract: The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia.
Patent EA-011266-B1 (EA)
Title: Native language internet address system
Inventor: LEE PAN JUNG
IPC: H04L12/70
Filed: 2005-06-03
Abstract: A native language Internet address system is provided. The native language Internet address system can accommodate data of various languages and regions, be written in Unicode, and process various letters of the world unlike an existing hierarchical domain written in Letter, Digit, and Hyphen (LDH). Further, a single system is provided which incorporates native language Internet addresses of the world to provide service.
Patent EA-012694-B1 (EA)
Title: Separation method using an itq-29 zeolite material
Inventor: CORMA CANOS AVELINO
IPC: C01B39/04
Filed: 2005-09-15
Abstract: The invention relates to a method of separating the components of a mixture. The inventive method is characterised in that it comprises the following steps: (a) the bringing into contact of the components of a mixture, selected from (i) at least two hydrocarbons, (ii) a mixture containing at least nitrogen and oxygen and (iii) at least one hydrocarbon and water, with an ITQ-29 zeolite material having a T (IV)/T (III) ratio of greater than 7, whereby T(IV) denotes one or more tetravalent elements and T(III) denotes one or more trivalent elements; (b) preferential absorption of one or more of the components by the ITQ-29 zeolite material; and (c) recovery of one or more of the components, preferably for the separation of hydrocarbon mixtures, such as linear or branched olefins of paraffins.
Patent EA-014500-B1 (EA)
Title: Parking garage
Inventor: MORASCH LUDWIG
IPC: E04H6/42
Filed: 2005-12-01
Abstract: Parking garage having at least two parking areas inside said parking garage, each parking area comprising a plurality of parking spaces adjacent to a wall, a wall segment of said wall extending along said plurality of parking spaces, said wall segment having a color pattern comprising at least two contrasting colors, whereby the color patterns of wall segments of different parking areas differ in color and in the pattern of the color patterns.
Patent EA-016490-B1 (EA)
Title: Pseudoinfectious flavivirus and uses thereof
Inventor: FROLOV ILYA
IPC: A61K39/12
Filed: 2007-02-27
Abstract: The present invention discloses a replication-deficient pseudoinfective virus belonging to the Flaviviridae family that lack the capsid gene, where the replication- deficient pseudoinfective virus propagates only in cells expressing the capsid or capsid, prM and envelope protein of the flavivirus. The present also discloses the method of producing such viruses on a large scale and the use of these pseudoinfective viruses as vaccines for preventing diseases caused by infections of humans or animals by the viruses belonging to this family.
Patent EA-015802-B1 (EA)
Title: Reconstituted surfactants having improved properties
Inventor: JOHANSSON JAN
IPC: A61K38/16
Filed: 2007-09-28
Abstract: The present invention is directed to a reconstituted surfactant comprising a lipid carrier, a polypeptide analogue of the native surfactant protein SP-C, and a polypeptide analogue of the native surfactant protein SP-B. The invention is also directed to the pharmaceutical compositions thereof and to its use for the treatment or prophylaxis of RDS and other respiratory disorders.
Patent EA-021172-B1 (EA)
Title: Intraocular lens supporter
Inventor: PARK KYONG JIN
IPC: A61F2/14
Filed: 2007-09-21
Abstract: Disclosed is an intraocular lens supporter having a control ability. One embodiment of the present invention provides an intraocular lens supporter that is inserted into a capsular sac, including a first face coming in contact with an inner surface of the capsular sac in at least one point as a structural body that is extended along an equatorial region of the capsular sac; and a second face arranged opposite to the first face, wherein, in a section where the structural body is cut along a virtual plane in a visual axis direction (Y direction) of an eye lens, the first face is provided at a length as much as 3/4 to 3 times of a length (d5, d10) of a region where a zonule of Zinn is coupled to an outer surface of the capsular sac.
Patent EA-017351-B1 (EA)
Title: Antihistaminic and antiallergic agent and a method for the production thereof
Inventor: GLUSHKOV ROBERT GEORGIEVICH
IPC: A61P27/14
Filed: 2008-03-20
Abstract: The invention relates to a range of original xanthine derivatives substituted in 1- and 7-positions with benzhydryl-4-piperazinyl-1-alkane fragments. A method for obtaining 3-methyl-7-[4-(benzhydryl-4-piperazinyl-1)butyl]xanthine and the salts thereof with organic and inorganic acids by alkylating the 7-potassium salt of 3-methylxanthine by 1,4-dibromobutane, by subsequently interacting the thus formed 7-(4-bromobutyl)-3-methylxanthine with 1-benzhydrylpiperazinyl and by neutralising the thus obtained radical 7-[4-(4-benzhydrylpiperazinyl-1)butyl]-3-methylxanthine by an organic or inorganic acid is also disclosed.
Patent EA-016492-B1 (EA)
Title: Catalytic hydrogenation of carbon dioxide into syngas mixture
Inventor: MAMEDOV AGADDIN M KH
IPC: C01B32/40
Filed: 2008-04-23
Abstract: The invention relates to a process of making a syngas mixture containing hydrogen, carbon monoxide and carbon dioxide, comprising a step of contacting a gaseous feed mixture containing carbon dioxide and hydrogen with a catalyst, which catalyst substantially consists of Mn oxide and an oxide of at least one member selected from the group consisting of Cr1 Ni, La, Ce, W, and Pt. This process enables hydrogenation of carbon dioxide into carbon monoxide with high selectivity, and good catalyst stability over time and under variations in processing conditions. The process can be applied separately, but can also be integrated with other processes, both up-stream and/or down-stream; like methane reforming or other synthesis processes for making products like alkanes, aldehydes, or alcohols.
Patent EA-020914-B1 (EA)
Title: Mobile communication system, base station apparatus and mobile station apparatus
Inventor: YAMADA SHOHEI
IPC: H04W72/04
Filed: 2008-06-03
Abstract: When a mobile station (200) is out of uplink synchronization, an efficient procedure is realized no matter whether a dedicated signature can be allocated. In a mobile communication system in which a base station (100) transmits a DL-SCH to a mobile station (200), when the mobile station (200) is out of uplink synchronization and detects resource allocation, the mobile station (200) performs a random access to the base station (100). When the base station (100) detects a signature by using a random access channel, it transmits a preamble response to the mobile station (200). When the mobile station (200) receives the preamble response, it transmits message (3) to the base station (100).
Patent EA-016113-B1 (EA)
Title: Axle assembly for a commercial vehicle and method for producing said axle assembly
Inventor: SCHMITZ PETER
IPC: B60B35/02
Filed: 2008-10-27
Abstract: The invention relates to an axle assembly for a commercial vehicle, cargoes and for non-transport operations having an axle (2) manufactured from a metal material and having at least one trailing arm (8) manufactured from a metal material, in which the axle (2; 102) with a hollow coupling section (4; 110) is seated such that the axle (2; 102) and the trailing arm (8; 103, 104) are connected to one another rotationally fixed. In the axle assembly, the properties of the metal materials of the connection section of the trailing arm and of the coupling section of the axle are adapted to one another such that the modulus of elasticity of the connection section is less than the modulus of elasticity of the coupling section and/or the breaking strength of the connection section is greater than the breaking strength of the coupling section and/or the yield strength Rs, or if the metal material does not have a clearly defined yield strength Rs, the proof stress Rof the metal material, of which the connecting portion of the trailing link is made, is higher than the yield strength Rs or proof stress Rof the metal material of the coupling portion, encompassed by the connecting portion of the axle.
Patent EA-018512-B1 (EA)
Title: Pyrrolo[2,3-d]pyrimidin derivatives as protein kinase b inhibitors
Inventor: JOHNSON PAUL DAVID
IPC: A61K31/519
Filed: 2008-10-09
Abstract: The invention relates to a compound of (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide or a pharmaceutically acceptable salt thereof, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to a pharmaceutical composition comprising said compound, using said compound in the treatment of diseases mediated by PKB and methods for preparing said compound.
Patent EA-016498-B1 (EA)
Title: Blade unit for a safety razor
Inventor: VOLODIN ALEXANDER TARASOVICH
IPC: B26B21/22
Filed: 2009-09-28
Abstract: A blade unit for a safety razor comprises a plurality of elongated blades (4) with a continuously curved cutting edge (8). The shape of the cutting edge (8) is defined according to the formula R-k*L, where Ris the bending radius of the blade; k is a coefficient of proportionality ranging from 1 to 5; and L is the chord length of a curve with a radius of R. The blades (4) have a third support point. This provides for easy and effective shaving.
Patent EA-029940-B1 (EA)
Title: Use of a composition for treating and preventing a disease related to mucosa of a respiratory tract
Inventor: LIN SHYH-SHYAN
IPC: A61P37/08
Filed: 2012-07-02
Abstract: Provided is the use of a composition of hyaluronic acids (HA) for treating or preventing disorders or diseases related to the mucosa of a respiratory tract. The composition includes a mixture of HAs having different average molecular weights and different rheological, isolation, tissue scaffold and degradation properties. The resulting formulation demonstrates an optimal balance between adhesion, tissue scaffold and treating time on the treatment or prevention of disorders and diseases related to the mucosa of a respiratory tract.
Patent EA-022587-B1 (EA)
Title: Unloading and loading crane arrangement, container terminal and method for unloading and loading a ship
Inventor: KOCH FRANCISCUS
IPC: B66C19/00
Filed: 2012-02-03
Abstract: The invention provides an unloading and loading crane arrangement comprising a boom, in particular a projecting boom, for unloading cargo from or loading cargo onto a ship using a gripper attached to the boom; and a transverse conveyor track for moving the unloaded cargo inland in the transverse direction and moving the cargo to be loaded shipward; characterized in that the arrangement is provided with a conveyor floor with a vehicle which can be moved across the latter at least in the transverse direction for displacing cargo, which conveyor floor has a first conveyor floor part where the vehicle can receive a cargo from the gripper and a cargo on the vehicle can be presented to the gripper, and has a second conveyor floor part for presenting cargo from the vehicle to the transverse conveyor track and receiving cargo on the vehicle from the transverse conveyor track.
Patent EA-026719-B1 (EA)
Title: PHARMACEUTICAL COMPOSITION COMPRISING (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4,b]INDOL]-4-AMINE AND AN MELOXICAM
Inventor: FROSCH STEFANIE
IPC: A61P29/00
Filed: 2013-05-16
Abstract: The invention relates to a pharmaceutical composition comprising a first pharmacologically active ingredient, which is selected from a compound in accordance with chemical formula (I)and the physiologically acceptable salts thereof, and a second pharmacologically active ingredient, which is a meloxicam or the physiologically acceptable salts thereof.
Patent EA-033242-B1 (EA)
Title: Improved nucleic acids and human papilloma virus proteins, vaccines and compositions based thereon and methods of inducing an immune response against hpv using the same
Inventor: WEINER DAVID B
IPC: C07K1/00
Filed: 2011-10-12
Abstract: Provided are improved nucleic acid molecules encoding anti-HPV immunogen proteins that include consensus HPV 6, HPV 11, HPV 33 and HPV 58 E6 and E7. Furthermore, provided are anti-HPV pharmaceutical compositions, recombinant vaccines and live attenuated vaccines comprising said nucleic acid molecules, as well as methods of inducing an immune response in an individual against HPV comprising administering to the individual said pharmaceutical compositions, recombinant vaccines or live attenuated vaccines.
Patent EA-037501-B1 (EA)
Title: METHOD OF TREATING DUCHENNE MUSCULAR DYSTROPHY BY ADMINISTERING AN ANTI-Flt-1 ANTIBODY
Inventor: JOSIAH SERENE
IPC: C07K16/28
Filed: 2014-01-28
Abstract: The present invention provides, among other things, methods and compositions for treating muscular dystrophy, in particular, Duchenne muscular dystrophy (DMD) by administering an anti-Flt-1 antibody. In some embodiments, a method according to the present invention includes administering to an individual who is suffering from or susceptible to DMD an effective amount of an anti-Flt-1 antibody, or antigen binding fragment thereof, such that at least one symptom or feature of DMD is reduced in intensity, severity, or frequency, or has delayed onset.
Patent EA-033457-B1 (EA)
Title: Method of treating cancer in patients with mutations in ros1, ntrk1, ntrk2 and/or ntrk3 genes
Inventor: LIM JONATHAN
IPC: A61P35/04
Filed: 2015-02-19
Abstract: Provided are methods of treating cancer in a patient, wherein said patient is known to possess at least one genetic alteration in at least one target gene selected from ROS1, NTRK1, NTRK2 and NTRK3, comprising administering to said cancer patient a therapeutically effective amount of N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide or a pharmaceutically acceptable salt thereof. According to preferred embodiments, said cancer is selected from non-small cell lung cancer, papillary thyroid cancer, neuroblastoma, pancreatic cancer and colorectal cancer.
Patent EA-037553-B1 (EA)
Title: Method, device for manufacturing transformers with a core made of amorphous material, and transformer thus produced
Inventor: DE LUCIA MAURIZIO
IPC: H01F41/02
Filed: 2016-03-11
Abstract: The invention relates to a device for the production of a transformer, comprised of at least two electrically conductive windings (A, B, C) adjacent to one another, and a ferromagnetic core (N1; N2; N3) linked to the two electrically conductive windings, formed by wound strip-shaped ferromagnetic material. The device comprises guide members (9) configured and arranged so as to define a closed path linked to the two electrically conductive windings, along which one or more strip-shaped ferromagnetic materials can be wound from at least one coil (R; R1-R18).
Patent EA-035374-B1 (EA)
Title: Cd48 antibodies and conjugates thereof
Inventor: LEWIS TIMOTHY
IPC: C07K16/18
Filed: 2016-03-17
Abstract: The invention provides murine, chimeric and humanized antibodies that specifically bind to CD48 and conjugates thereof.
Patent EA-034404-B1 (EA)
Title: Blade attachment assembly for mower blades driven in an oscillating manner
Inventor: SCHUMACHER HEINRICH GUENTER
IPC: A01D34/30
Filed: 2016-05-12
Abstract: The invention relates to a blade attachment assembly for mower blades driven in an oscillating manner, having a shaft (1) which defines a first longitudinal axis (X) and has a receiving space (4); a mower blade drive pin (2) engaging in the receiving space (4) and detachably connected to the shaft (1), which extends axially with respect to the first longitudinal axis (X), beyond the shaft (1), and defines a second longitudinal axis (Y) that is offset radially with respect to the first longitudinal axis (X), wherein a wall (5) of the shaft (1) that delimits the receiving space (4) has a first support face (6) curved in the circumferential direction; a top bearing holding area (13) of the mower blade drive pin (2) that engages in the receiving space (4) has a first contact face (14) that is in contact with the support face (6) and is curved opposite to the first support face (6); and connecting means (24) for the detachable connection of the mower blade drive pin (2) to the shaft (1), characterized in that an undercut (8) is formed in the wall (5) delimiting the receiving space (4), and in that the top bearing holding area (13) of the mower blades drive pin (2) has a collar (16) engaging in the undercut (8), wherein the undercut (8) is formed as a groove in the wall (5) that extends radially with respect to the second longitudinal axis (Y).
Patent EA-036656-B1 (EA)
Title: Fuel exchange system and fuel supply system for fuel systems
Inventor: BECKER HOLGER
IPC: F02D19/06
Filed: 2017-04-05
Abstract: The invention relates to the field of fuel systems for combustion engines. A first aspect of the invention relates to a system for exchanging different fuels which can be used to operate a combustion engine. Said system comprises a fuel exchange unit (17), a controller (21) and an exchange-return line (24). The fuel exchange unit (17) is designed to supply a first fuel (22), when the combustion engine is switched off, under pressure to the injection system (8), in order to exchange a second fuel (23) with the first fuel (22) in the injection system (8). A second aspect of the invention relates to a system for conveying a fuel (23, 61). The system comprises a medium converter (32, 80) having a moveable element (37, 38). Said medium converter (32, 80) is driven by the fluid (22, 60) through a drive unit (31), in which the fluid (22, 60) can be supplied to the medium converter (32, 80) via a first supply line (33.1) under differing pressures, and is also designed to convey the fuel (23, 61) by means of a pump action.