baber/WOPTO huggingface dataset:
Patent ES-8602818-A1 (ES)
Title: 5-Lipoxygenase inhibitors.
IPC: C07D513/16
Filed: 1984-10-29
Abstract: Compounds of the Formula I: < CHEM > and their pharmaceutically acceptable salts are inhibitors of the mammalian 5-lipoxygenase enzyme system of the arachidonic acid cascade. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation and are incorporated into pharmaceutical compositions. Certain of the compounds are novel. In the formula, Z is O, NCN, SO or SO2 R1 is H, C1-6 alkyl, benzyl, C1-6 acyl, C1-6 aminoacyl, (C1-6 alkylacyloxy)-(C1-6 alkyl), (C1-6 alkoxy)-(C1-6 alkyl), -(CH2)nCOOR6 where n is, 0, 1, 2, 3 or 4, CN, (C1-6 alkyl)acyloxy(C1-6 alkoxy)carbonyl, -C(R7)=C(R7)COOR6 or SO2R10 each of R2, R3, R4 and R5, independently of the others, is hydrogen, C1-6 alkyl, C2-6 alkenyl or -(CH2)nM, where n is 0 or an integer from 1 to 6 and M is(a) OR16 (b) halogen (c) CF3. (d) SR16 (e) phenyl (f) substituted phenyl where the substituents(s) is/are C1-3 alkyl, halogen, CN, C1-3 alkoxy, OH, (CH2)nNR8R9 where n is 0, 1 or 2, CF3, COOR6 or CH2COOR6 (herein called <<substituted phenyl as defined>>) (g) COOR6 (h) -CO-R14 (i) tetrazolyl (j) NH-CO-R7 (k) NR8R9 (l) NHSO2R10 (m) -CO-CH2OH (n) SOR11 where R11 is C1-6 alkyl, phenyl, substituted phenyl as defined, (CH2)mCOOR6, where m is an integer from 1 to 6, or CF3 (o) CONR8R9 (p) SO2NR8R9 (q) SO2R13 where R13 is OH, C1-6 alkyl, H phenyl, substituted phenyl as defined, (CH2)mCOOR6 or CF3 (r) NO2 (s) -OCO-R14 (t) -OCO-NR8R9 (u) -OCO-OR7 or (v) -CN each R16, independently of any other, is H (C1-6 alkoxy)(C1-6 alkyl) (C1-6 alkyl)acyloxy(C1-6 alkyl) C1-6 alkyl substituted phenyl as defined -CH2)mCOOR6 CN: C1-5 alkylacyl C1-4 perfluoroalkyl phenyl benzyl or CH2-R12 where R12 is C1-5 alkyldimethylamino each R6, independently of any other, is H, C1-6 alkyl, benzyl or phenyl each R14, independently of any other, is H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkyl)acyloxy(C1-6 alkoxy), (CH2)nCOOR6 where n is 0 or an integer from 1 to 4, phenyl or substituted phenyl as defined or is such that R14COOH is an essential amino acid each of R8 and R9, independently of the others, is H, phenyl, substituted phenyl as defined or C1-4 alkyl, or NR8R9 is a heterocycloalkyl of 5 to 8 ring atoms and each R7, independently of the others, is H, C1-6 alkyl, benzyl, phenyl or (C1-6 alkyl)acyloxy-(C1-6 alkoxy) each R10 is independently OH, C1-6 alkyl, C1-6 alkoxy, phenyl or p-tolyl or any two of R1, R2, R3, R4 or R5 are joined to form an additional ring of 5 to 7 members that optionally contains a carbonyl group and/or a hydroxyl group as substituent(s), and that has 0, 1 or 2 double bonds, and such that, if R1 is a constituent of the ring, one member is nitrogen and the other are carbon and if R1 is not a constituent of the ring, all the members are carbon and T is hydrogen or OR15 where R15 is hydrogen, C1-6 alkyl, C1-6 alkylacyl, phenyl-(C1-8 alkyl)acyl, SO2R10, arylsulfonyl, -CO-phenyl or substituted phenyl as defined.
Patent ES-8607667-A1 (ES)
Title: Second Breakdown protection circuit for X-Ray generator inverter.
IPC: H02H7/122
Filed: 1984-12-19
Abstract: In an X-ray generator operating with a pulse-width-modulated transistor inverter, circuitry is provided to sense the collector-emitter voltage of each of the transistors and to responsively turn off the transistor when that voltage level reaches a predetermined threshold level which is indicative of a problem. Provision is included to inhibit the operation of the protective circuit during the time period in which the transistor is turning on so as to thereby allow for higher voltages during that critical period.
Patent ES-8605445-A1 (ES)
Title: Method of preparation of crystalline layered structure alcali metal silicates.
IPC: C01B33/187
Filed: 1985-01-02
Abstract: Prodn. of crystalline laminar alkali silicate (I) in aq. medium is carried out by treating an aq. soln. of alkali silicate (II) or amorphous (II) with a molar ratio of M2O/SiO2 (M = an alkali metal) of 0.24-2.0 with sufficient acid cpd. to give a molar ratio of M2O (not neutralised)/SiO2 of 0.05-0.239, adjusting to a molar ratio of SiO2/H2O of 1:5-100 by dilution if necessary and keeping the reaction mixt. at 70-250 deg. C until (I) crystallises out. - Pref. the (II) soln. is Na water glass, pref. contg. 22-30 wt.% SiO2 and 5-9 wt.% Na2O. The reaction temp. is 130-210 deg. C. The mixt. is treated with 0.01-30 wt.% (I) seeds w.r.t. SiO2 in (II).
Patent ES-8602408-A1 (ES)
Title: Granules with controlled release of active ingredient
IPC: A61K9/54
Filed: 1985-02-20
Abstract: The granules are made by combining the dry inert components, pref. obtained from saccharose and starch with conc. solns. of inert components, drying and sieving to the desired size. - They are then coated with the active principle, alone or mixed with film-forming solns., which can be repeated to obtain several layers.
Patent ES-8702377-A1 (ES)
Title: 3-Mercapto-1,2,4-triazacycloalcadiene derivatives.
IPC: C07D249/12
Filed: 1985-03-15
Abstract: 3-Mercapto-1,2,4-triazacycloalkadiene derivatives of the formula I < IMAGE > in which the radicals R1 and R2 independently of one another denote aryl which is unsubstituted or substituted by aliphatic hydrocarbon radicals, free, etherified or esterified hydroxyl, optionally S- oxidised etherified mercapto, free or aliphatically substituted amino, nitro and/or trifluoromethyl or denote optionally N-oxidised heteroaryl radicals, n represents 0, 1 or 2 and R3 denotes an aliphatic hydrocarbon radical substituted by an optionally esterified or amidated carboxyl group, cyano or, in higher than the alpha -position, by one or two optionally esterified or etherified hydroxyl group(s), one or two etherified mercapto group(s), an oxidised mercapto group or an oxo group, and their salts have analgesic properties and can be used as medicaments for the treatment of painful inflammatory diseases. They are prepared by eliminating HY from a compound of the formula < IMAGE > in which one of the radicals Y1 and Y2 denotes a radical Y which can be eliminated and the other denotes a hydrogen atom and Y3 and Y4 together represent an additional bond, or in which Y4 denotes a radical Y which can be eliminated and Y3 denotes hydrogen and Y1 and Y2 represent an additional bond, or from a salt thereof with the introduction of an additional bond.
Patent ES-8606093-A1 (ES)
Title: Vaporous amine catalyst spray method of applying a film to a substrate
IPC: C08G18/42
Filed: 1985-05-29
Abstract: Disclosed is a novel method for applying a film of a coating composition in liquid form onto a substrate which applied film cures rapidly at room temperature without heat curing. The coating composition comprises a hydroxyl-functional compound (preferably bearing aromatic-hydroxyl groups) and a multi-isocyanate cross-linking agent, optionally dispersed in a fugitive organic solvent therefor. The method comprises the steps of: (a) concurrently generating an atomizate of said coating composition and a carrier gas bearing a catalytic amount of a vaporous tertiary amine (b) mixing said atomizate and said vaporous catalytic amine-bearing carrier gas flow and (c) directing said mixture of step (b) onto said substrate to form said applied film.
Patent ES-8604593-A1 (ES)
Title: Imidazo(1,2-a)quinolines, their preparation and their therapeutical use.
IPC: A61K31/435
Filed: 1985-08-06
Abstract: 2-Aryl-imidazol(1,2-a) quinoline-1-acetamides of formula (I) and their salts are new: Ar = phenyl opt. monosubstd. by halogen, Me, OMe, SMe or SO2Me; Y = H, halogen or Me in the 6, 7 or 8 posn.; R1 and R2 = H, Me or Et, or R1+R2 = (CH2)4, (CH2)5, CH2CH2N(R3)CH2CH2 or CH2CH2OCH2CH2; R3 = Me or COOEt.
Patent ES-8608603-A1 (ES)
Title: Jigger machine for continuous treatment of fibrous materials
IPC: D06B3/32
Filed: 1985-08-07
Abstract: Modified jigger machine for continuous treatment of fibrous piece-type materials. It is composed of: a cylindrical body 2 with two domed end walls 3, 4; positioning feet 5 and a tank 12 which contains a treatment agent 13 separated by a partition 11 of the cylindrical body 8 from 6; a principal access device 6 and a secondary access device 7 which are equipped with cylindrical bodies 8, 9 and with domed covers 15, 16 fixed in their position by closure devices 17, 18; cylinders 39, 40 for transporting thread 41 during operation of the machine, which are supported by the shafts 37, 38; submerged cylinders 84 which carry chain wheels 85, 86, accompanying pendulums 7 "enfurolados" at 88 and accompanying rollers and wideners 89, 90, which make the fabric travel through the bath 13; a maximum-pressure safety valve 91 and a pneumatic cylinder 93 with its rod 94 for hermetic closure of 15. It is used in the textile industry (dyeing and washing).
Patent ES-8604930-A1 (ES)
Title: Substituted 1-pyridyloxy-3- indolylakylamino-2-propanols, preparation, and use thereof
IPC: C07D413/14
Filed: 1985-09-19
Abstract: 1-(Pyridinyloxy)-3-(indolylalkylamino)- 2-propanols, novel cardiovascular agents having vasodilator activity and a range of adrenergic beta-receptor blocking action, are prepared by any one of three routes that comprise a novel general process. The general process comprises coupling a hydroxyl- or halogen- substituted pyridine with a suitable halogen- or hydroxyl-substituted propanol or incipient propanol intermediate and the products of these couplings are also novel. In the preferred of the three coupling routes, product 1-(pyridinyloxy)-3-(indolyl- alkylamino)-2-propanols are formed directly in the other two coupling routes further processing of the coupling products is required to form the 1-(pyridinyloxy)-3-(indolylalkylamino)- 2-propanols. Preferred compounds bear an amide or cyano substituent in the 3-position of the pyridine ring.
Patent ES-8706550-A1 (ES)
Title: Method and appartus for delivering a predetermined amount of material to a container.
IPC: B65B1/36
Filed: 1986-02-05
Abstract: A method and apparatus for delivering a predetermined amount of material into a predetermined position on each of a series of moving trays while avoiding spillage of the product onto other portions of the trays. A conveyor lifts the material onto a shaker pan which delivers the material in an even flow on to a rotating turntable having a plurality of radially extending gutters thereon. The turntable directs the material to flow along the gutters and into a plurality of hoppers disposed at the periphery of the turntable. Once a hopper is full, any excess material falls onto a drip tray which returns the material back to a supply bin. The filled hoppers are sequentially rotated above the trays, which are moving on a conveyor, to release material onto a predetermined area of each successive tray. A funnel disposed between the hopper and the tray facilitates delivery of material onto the tray. The funnel is lowered toward the tray to deliver material, advanced in synchronism with the tray, elevated to clear the tray and material, and then returned to a position adjacent to a hopper.
Patent ES-8704437-A1 (ES)
Title: Process and apparatus for producing glazed ceramic tiles, and tiles so obtained
IPC: B28B11/04
Filed: 1986-02-11
Abstract: The process provides for the firing in a furnace of ceramic bodies and their coating in an incandescent state on one face with dry granular or powdered glaze when all firing reactions of the ceramic bodies have substantially reached completion a subsequent thermal treatment fires the glaze and gradually cools the tile. The apparatus for carrying out the process provides for a furnace for firing ceramic bodies, the furnace being divided into two section between which is a device for distributing glaze over the ceramic bodies conveyed to pass through the furnace.
Patent ES-8800226-A1 (ES)
Title: Imidazodiazepine derivatives.
IPC: C07D487/14
Filed: 1986-02-27
Abstract: Compounds which are imidazodiazepine derivatives of the formula < IMAGE > I wherein A together with the carbon atoms denoted by alpha and beta signifies the group < IMAGE > one of R1 and R2 signifies hydrogen and the other signifies hydrogen, halogen or trifluoromethyl, R3 and R4 each signify hydrogen or halogen and n signifies the number 2 or 3, the compounds having the (S)- or (R,S)-configuration with reference to the carbon atom denoted by gamma , and their pharmaceutically acceptable acid addition salts have been discovered which possess anxiolytic, anticonvulsant, muscle relaxant and sedative-hypnotic properties. They can be prepared into compositions, including pharmaceutically acceptable ones, using suitable inert carriers.
Patent ES-8702258-A1 (ES)
Title: Torque sensing braking controller for brakes.
IPC: F16D65/22
Filed: 1986-03-25
Abstract: A torque sensing braking controller senses directly the braking torque exerted by a rotating element (14, 114, 214, 314) upon at least one friction element (20, 222, 320 and 332) of the brake (10, 210, 310), such that the sudden decrease in torque which occurs when wheel lock-up and skidding occurs is sensed and results in the communication of an increased output pressure to oppose outward displacement of at least one differential area piston (40 and 50, 240 and 250, 340) by fluid pressure received from the master cylinder, the increased output pressure causing the piston to reduce braking force exerted by the friction element against the rotating element (14, 114, 214, 314) so that the rotating element may recommence rotation. The torque sensing braking controller may be utilized in drum brake (10), duo-servo drum brake (210), and disc brake (310) assemblies. In each instance, the brake utilizes the sudden drop in braking torque to create an increased output pressure which opposes displacement of a differential area piston and effects release of the rotatable element so that wheel rotation recommences.
Patent ES-8801775-A1 (ES)
Title: Extruded plastic material for making three recloseable bag sections.
IPC: B65D33/30
Filed: 1986-04-04
Abstract: Material and method for making three reclosable bag sections from separable fastener equipped web, comprising folding opposite free portions of the web upon themselves and folding an intervening portion of the web upon itself and thereby providing three bag sections in a generally Y orientation. Separably interlockable fastener profiles adjacent to juncture of the three sections being arranged to provide a respective bag top separable profile fastener assembly along each of the bag sections. The bag sections are separable from one another at the juncture. Pull flanges may be provided along the separable fastener assembly of each of the sections.
Patent ES-8700906-A1 (ES)
Title: Flexible sugarless chewing gum.
IPC: A23G4/00
Filed: 1986-03-27
Abstract: Sugarless stick chewing gum which is flexible for extended shelf life periods is made with cooked aqueous hydrogenated starch hydrolysate having a moisture content of about 8 +/- 4%, and which may also contain glycerine.
Patent ES-8707256-A1 (ES)
Title: 21-Substituted thiosteroids.
IPC: C07J31/00
Filed: 1986-06-25
Abstract: A 21-substituted thiosteroid represented by the general formula < IMAGE > (I) wherein R1 represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 or 6 carbon atoms, a phenyl group, or a benzyl group which may have a substituent on the benzene ring, R2 represents an alkanoyl group having 2 to 6 carbon atoms, R3 represents a hydrogen atom or a methyl group, X represents a hydrogen or halogen atom, and the dotted line between 1- and 2-positions represents an optional bond. These compounds are useful an anti-inflammatory agents.
Patent ES-8900205-A1 (ES)
Title: Process for automatically regulating weight loss during haemodialysis
IPC: G05B11/00
Filed: 1986-06-20
Abstract: Process whereby weight loss is regulated by means of constant monitoring of the patient's weight, acting automatically on the negative pressure regulator of the haemodialysis liquid circuit located on the haemodialysis monitor. In this way, by knowing initially the actual weight of the patient, the final desired weight and the duration of the session, and by continuously monitoring the patient's weight throughout the process, the necessary negative pressure on the haemodialysis liquid circuit will be automatically established on the negative pressure control of the haemodialysis monitor in order automatically to achieve, at the end of the session, a situation in which the actual weight of the patient is equal to the final weight desired when the session began.
Patent ES-8900034-A1 (ES)
Title: Infrared laser catheter apparatus.
IPC: G02B6/24
Filed: 1988-04-15
Abstract: Laser energy produced by a laser operating in the mid-infrared region (approximately 2 micrometers) is delivered by an optical fiber in a catheter to a surgical site for biological tissue removal and repair. Disclosed laser sources which have an output wavelength in this region include: Holmium-doped Yttrium Aluminum Garnet (Ho:YAG) ,Holmium-doped Yttrium Lithium Fluoride (Ho:YLF) , Erbium-doped YAG, Erbium-doped YLF and Thulium-doped YAG. For tissue removal, the lasers are operated with relatively long pulses at energy levels of approximately 1 joule per pulse. For tissue repair, the lasers are operated in a continuous wave mode at low power. Laser output energy is applied to a silica-based optical fiber which has been specially purified to reduce the hydroxyl-ion concentration to a low level. The catheter may be comprised of a single optical fiber or a plurality of optical fibers arranged to give overlapping output patterns for large area coverage.
Patent IE-911266-A1 (IE)
Title: 2(5H)-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca2+¹CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS
IPC: A61K31/365
Filed: 1991-04-16
Abstract: Compounds of the formula  <IMAGE>  in which R is alkyl, arylalkyl or substituted arylkalkyl, or alkenyl containing one or more olephinic bonds; X is O, NH or NR1, where R1 is alkyl of 1 to 20 carbons or arylalkyl; and Y is H, alkyl of 1 to 20 carbons, arylalkyl, aryl, substituted aryl, substituted arylalkyl, alkenyl containing one or more olephinic bonds PO(OH)2, PO(OH)OR2, PO(OH)R2 PO(OR2)2, where R2 is independently alkyl of 1 to 20 carbons, phenyl, or substituted phenyl, further Y is CO-R3, CO-OR3, CONHR3, SO2R3, SO2NHR3, (CH2)n-O-R3, or (CH2)n-O-(CH2)m-O-R3, where n, and m, are integers and are independently 1 to 20 and R3 is H, alkyl, alkenyl containing one or more olephinic bonds, aryl, substituted aryl, arylalkyl or substituted arylalkyl, with the proviso that when Y is CO-R3, CO-OR3, and CONHR3 then R3 is not hydrogen, are disclosed. The compounds are Ca2+ channel antagonist, have weak or no activity as inhibitors of phospholipase A2, and are anti-inflammatory agents.
Patent IE-902956-A1 (IE)
Title: Pyrido [3,4-b] [1,4]benzoxazepines, a process for their¹preparation and their use as medicaments
IPC: A61P25/04
Filed: 1990-08-15
Abstract: The present invention relates to novel pyrido[3,4-b][1,4]benzoxazepines and a process for their preparation. The compounds of the invention exhibit antidepressant, analgetic and memory dysfunction relieving activities and can, therefore, be used as medicaments.
Patent IE-913328-A1 (IE)
Title: Benzene, pyridine and pyrimidine derivative
Inventor: KIMURA TEIJI
IPC: C07D401/12
Filed: 1991-09-23
Abstract: A benzene, pyridine or pyrimidine derivative having the below shown formula is novle and useful as an anti-arteriosclerotic agent. <CHEM> wherein R<1> stands for a lower alkyl group, an amino group which may be substituted, or the like;     R<2> stands for a group represented by the formula: <CHEM> (wherein R<1><7> stands for an alkyl group), a group represented by the formula: - NH - R<1><8> (wherein R<1><8> stands for an alkyl group) or a group represented by the formula: <CHEM> (wherein R<1><9> stands for an alkyl group and n is an integer of 1 to 3); R<3> stands for a group represented by the formula: -O-(CH2)m-Y (Y stands for an imidazolyl or piperazinyl group, or the like and m is 1 to 6) or the like; R<5> stands for a hydrogen atom, a lower alkyl group, or the like; A stands for a group represented by the formula: <CHEM> (wherein R<6> stands for a hydrogen atom, a lower alkyl group, or the like), -N=, or the like; and B stands for a group represented by the formula: <CHEM> (wherein R<4> stands for a hydrogen or the like), -N=, or the like.
Patent IE-913371-A1 (IE)
Title: Can carton
Inventor: OLIFF JAMES R
IPC: B65D71/00
Filed: 1991-09-26
Abstract: A carton formed from a unitary blank for packaging a plurality of cans includes a top wall, side walls, foldably joined along their top edges respectively to opposite side edges of the top wall, a pair of lap panels foldably joined respectively to the bottom edges of the side walls and secured together in overlapping relation to form a composite bottom wall of the carton, an anchoring panel foldably joined to each end edge of each side wall and folded into flat face contacting relation with the inner surface of the associated side wall, masking structure for overlying the pricing indicia applied to individual cans, includes a masking panel foldably joined to each end edge of each lap panel and arranged with the inner edges thereof disposed in overlapping relation together with web structure foldably joined along one edge thereof to the adjacent edge of the associated anchoring panel and foldably joined along another edge thereof to the adjacent end of the associated masking panel.
Patent IE-913612-A1 (IE)
Title: New substituted azetidinones as anti-inflammatory and¹antidegenerative agents
IPC: A61P1/02
Filed: 1991-10-16
Abstract: New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e
Patent IE-914252-A1 (IE)
Title: Method to make matrix composites in which the matrix¹contains polybenzoxazole or polybenzothiazole
IPC: C08G75/00
Filed: 1991-12-06
Abstract: This application claims a method for using a dope solution that contains polybenzoxazole or polybenzothiazole polymer or copolymer. Fibers are prepregged with the dope, and the prepreg is be contacted with water or another coagulant to coagulate the polymer and form a matrix composite.
Patent IE-920659-A1 (IE)
Title: Method of producing d-ribose
Inventor: MIYAGAWA KENICHIRO
IPC: C12N15/52
Filed: 1992-02-28
Abstract: Disclosed are (1) a method of producing D-ribose which comprises cultivating a microorganism belonging to the genus Bacillus having D-ribose producing ability in a medium, the microorganism belonging to the genus Bacillus containing a DNA sequence participating in expression of a gluconate operon which is partly or wholly modified so as to highly express the gluconate operon in the microorganism belonging to the genus Bacillus, accumulating D-ribose, and collecting D-ribose thus obtained; (2) a novel microorganism belonging to the genus Bacillus having D-ribose producing ability transformed with DNA which contains a DNA sequence participating in expression of a gluconate operon which is partly or wholly modified so as to highly express the gluconate operon in the microorganism belonging to the genus Bacillus; (3) novel DNA in which a promoter of a gluconate operon of a microorganism belonging to the genus Bacillus is modified so as to highly express said gluconate operon in the microorganism belonging to the genus Bacillus; and (4) a novel vector into which DNA is introduced in which a promoter of a gluconate operon of a microorganism belonging to the genus Bacillus is modified so as to highly express the gluconate operon in the microorganism belonging to the genus Bacillus, whereby D-ribose can be produced in stable form in large amounts.