Patent SG-11201903514V-A (SG)
Title: Novel cd47 monoclonal antibodies and uses thereof
Inventor: WANG ZHENGYI
IPC: A61P35/00
Filed: 2017-10-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 April 2018 (26.04.2018) WIP0 I PCT omit VIII °nolo olomm H 100 Imo oimIE (10) International Publication Number WO 2018/075857 Al (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/00 A61P 35/00 (2006.01) C07K 16/18 C07K 14/705 (2006.01) C07K 16/28 (21) International Application Number: PCT/US2017/057535 (22) International Filing Date: 20 October 2017 (20.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2016/102720 20 October 2016 (20.10.2016) CN PCT/CN2017/076462 13 March 2017 (13.03.2017) CN PCT/CN2017/000329 27 April 2017 (27.04.2017) CN (71) Applicant: I-MAB [ /GB]; P.O. Box 31119, Grand Pavil- lon, Hibiscus Way, 802 West Bay Road, Cayman KY1-1205 (KY). (72) Inventors: WANG, Zhengyi; Suite 802, West Tower, 88 Shangke Road, Pudong New District, Shanghai 201210 (CN). FANG, Lei; Suite 802, West Tower, 88 Shangke Road, Pudong New District, Shanghai 201210 (CN). GUO, Bingshi; Suite 802, West Tower, 88 Shangke Road, Pudong New District, Shanghai 201210 (CN). ZANG, Jingwu; Suite 802, West Tower, 88 Shangke Road, Pudong New District, Shanghai 201210 (CN). (74) Agent: RAO, Weisun; GREENBERG TRAURIG LLP, 77 W. Wacker Dr., Suite 3100, Chicago, Illinois 60601 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (2006.01) (2006.01) (2006.01) (54) Title: NOVEL CD47 MONOCLONAL ANTIBODIES AND USES THEREOF Fig. 1 -41- IFS 5F9 -o- 2A1 1-1 • 4 N oc N oc O 1-1 O 2 Concentration Log (ng/rni) (57) : The present invention provides novel CD47 antibodies or immunologically active fragments thereof that have low immunogenicity in humans and cause low or no level of red blood cell depletion or hemagglutination, as well as pharmaceutical compositions containing such antibodies that can be used for treatment diseases mediated by CD47 or inhibition of phagocytosis or platelet aggregation. [Continued on next page] WO 2018/075857 Al MIDEDIMOMOIDEIREIDIONOMEHINHEHOIMIE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))