baber/WOPTO huggingface dataset:
Patent DE-68927479-D1 (DE)
Inventor: HORAN PAUL
IPC: A61K41/00
Filed: 1989-01-10
Granted: 1997-01-02
Abstract: Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeutically active substance, which is linked via a linking moiety to at least one hydrocarbon substituent selected so that the compounds is sufficiently non-polar to impart lipid binding capability to the compound. Thus, compounds of the invention are useful for site-selective delivery of therapeutic agents, and retention thereof at the selected site. Methods are provided for using various compounds of the invention in treatment of diseases or other pathological conditions. For example, methods are provided for treatment of: (1) post-angioplasty restenosis; (2) rheumatoid arthritis; (3) tumor cell proliferation, particularly tumor cells associated with ovarian cancer; and (4) psoriasis.
Patent DE-68927861-D1 (DE)
Inventor: COOK C EDGAR
IPC: C07J53/00
Filed: 1989-06-23
Granted: 1997-04-17
Abstract: A 11 beta -aryl-19-norprogesterone steroid of the formula:   <IMAGE> wherein (i) R1 is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, OH, OC(O)CH3, or OC(O)R5 , wherein R5 is C2-8 alkyl, C2-8 alkenyl, C2-8 alkynyl or aryl, R2 is H, R3 is H, C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl, R4 is H, CH3, F or Cl, R6 is H, (CH3)2N, CH3O, CH3CO, CH3S, CH3SO, CH3SO2, and X is O or NOCH3; or (ii) R1 and R2 taken together are a carbon-carbon bond and R3, R4, R6 and X are as defined above; or (iii) R1 and R3 taken together are -CH2- or -N=N-CH2-, R2 is H and R4, R6 and X are as defined above; or (iv) R2 and R3 taken together are =CH2 and R1 , R4, R6 and X are as defined above.
Patent DE-69000054-D1 (DE)
Inventor: DE SMET GABRIEL
IPC: B65D47/12
Filed: 1990-06-18
Granted: 1992-05-07
Abstract: An easy-open can, e.g. for liq. products, has a detachable disc (4) covering a hole (5) in the lid (3) of the can (1), which is detached to allow the can's contents to be poured. The disc can be made from the can lid, which. is shaped by dies prior to fitting to the can to produce the disc (4), which can be slightly curved in shape, and a stretched cylindrical edge round the hole, which can then be rolled and compressed to fix the disc in place and seal it. The edges (10e,10f) of the material of the lid surrounding the disc can be compressed with a sufficient effort which is appropriate to the sealing requirements and allowing the can to be easily opened, e.g. by a ring attached to the disc.
Patent DE-69001651-D1 (DE)
Inventor: POTTER TERRY A
IPC: C08G18/80
Filed: 1990-07-05
Granted: 1993-06-24
Abstract: The present invention is directed to coating compositions comprising a) polyisocyanates having a content of isocyanate groups blocked by blocking agents of about 10 to 35% by weight and containing about 0.5 to 10.0 % by weight of structural units corresponding to the formula  -CO-NH-NH-CO-  and b) polyhydroxy polyacrylates in an amount sufficient to provide an equivalent ratio of blocked isocyanate groups to hydroxyl groups of about 0.5:1.0 to 2.0:1.0. The present invention is also directed to the coatings prepared from these coating compositions. Finally, the present invention is directed to blocked polyisocyanates which have a content of isocyanate groups blocked by blocking agents of about 10 to 35% by weight and about 0.5 to 10.0 % by weight (calculated as -CO-NH-NH-CO-, MW 86) of structural units corresponding to the formula  -CO-NH-NH-CO-Q-  wherein  Q represents NH-NH-CO- or the group R-(CO-NH-NH-CO)n  R is an n + 1 valent hydrocarbon radical and n has a value from 1 to 3.
Patent DE-69004690-D1 (DE)
Inventor: BRACKETT TOM
IPC: B29C65/00
Filed: 1990-06-04
Granted: 1993-12-23
Abstract: A method of producing a fluidic module from two or more pieces (B1 B2) of plastic material having an intermolecular bonded interface, comprises forming an interface surface (2) on each piece, forming at least one fluidic passageway (4) in at least one of the interface surfaces, assembling the pieces with the interface surfaces in contact with each other and confining them against expansion. Heat is applied to the assembled pieces to induce their expansion against total or limited confinement to cause transmigration of molecules from one interface surface to the other to bond the pieces together.
Patent DE-69005123-D1 (DE)
Inventor: JOHNSEN ANDERS
IPC: B25H1/00
Filed: 1990-11-19
Granted: 1994-01-20
Abstract: PCT No. PCT/SE90/00745 Sec. 371 Date Jul. 14, 1992 Sec. 102(e) Date Jul. 14, 1992 PCT Filed Nov. 19, 1990 PCT Pub. No. WO91/08074 PCT Pub. Date Jun. 13, 1991.In a device for releasable connection of two members (2, 8) co-operating wedge surfaces (12, 17 and 13, respectively) are provided on the members. A first member (2) comprises two tightening devices (14, 16) arranged to actuate the second member (8) so that a component of the tightening force actuates the members towards each other, and another component of the tightening force actuates the wedge surfaces (12, 17 and 13, respectively) to co-operate so that also the wedge surfaces actuate the members towards each other. The device is designed for connecting the members (2, 8) in two relative positions, between which the members are rotated 180 degrees relative to each other.
Patent DE-69005998-D1 (DE)
Inventor: SCHMIDT DONALD L
IPC: B01D15/00
Filed: 1990-11-30
Granted: 1994-02-24
Abstract: Cationic organic impurities such as ternary sulfonium ions and quaternary ammonium and phosphonium compounds are effectively removed from polar liquids such as water or water/alcohol mixtures by contacting the polar liquid with an absorbent comprising a trinitroarenol such as a picric acid. This method is particularly effective for removing such cationic impurities from polar liquids containing organic zwitterions.
Patent DE-69017459-D1 (DE)
Inventor: CZERNUSZKA JAN T UNIVERSITY OF
IPC: H01J37/244
Filed: 1990-09-07
Granted: 1995-04-06
Abstract: Apparatus for imaging dislocations in materials using a scanning electron microscope and in which an electron detector is placed very close to the specimen being examined, without the intervention of a retarding field filter; low-loss electrons are collected by ensuring that the detector accepts electrons received from the specimen at an obtuse angle with respect to the incident electron beam; and an image enhancement system is used.
Patent DE-69030199-D1 (DE)
Inventor: CALE KENNETH WILLIAM
IPC: A23F5/48
Filed: 1990-01-15
Granted: 1997-04-17
Abstract: The present invention relates to a soluble coffee aromatized with a collected fraction of beneficial coffee volatiles such as diacetyl and acetaldehyde released from the thermal hydrolysis of partially extracted roasted and ground coffee which has been subjected to atmospheric extraction to extract a majority of the arabinogalactan therefrom. The resulting soluble coffee comprises 25 to 125 ppm by weight acetaldehyde, 10 to 40 ppm by weight diacetyl, greater than 175 ppm total volatiles, a ratio of (acetaldehyde + diacetyl)/3-methyl butanal of 1.75 to 10 by weight and a ratio of acetaldehyde/3-methyl butanal of 1.5 to 10 by weight.
Patent DE-69032141-D1 (DE)
Inventor: LOEFGREN LARS
IPC: B32B27/06
Filed: 1990-01-02
Granted: 1998-04-23
Abstract: A laminated material for the manufacture of packing containers with good gas and aroma barrier properties and or parts for such containers, and a method for the manufacture of the laminated material (1). The laminted material (1) comprises a first partial laminate (1) comprising a carrier layer (2) of thermoplastics and a barrier layer (3) of inorganic material of 50-500  ANGSTROM thickness serving as a gas and aroma barrier, and a second partial laminate (1b) comprising a carrier layer (4) and a barrier layer (5) of inorganic material of 50-500  ANGSTROM  thickness serving as a gas and aroma barrier, these partial laminates being joined to one another by means of an intermediate layer (6) of bonding agent, their respective barrier layers facing inwards towards one another.
Patent DE-69101919-D1 (DE)
Inventor: ERIKSSON JUHA P
IPC: F16L59/12
Filed: 1991-09-27
Granted: 1994-06-09
Abstract: A pipe surrounded by a sleeve (17,18) spaced from the pipe by a spacer (11,12) characterised in that the perimeter of the spacer is interrupted by a longitudinal gap (14) and the sleeve is made of flexible meshed material whose longitudinal edges are bent round the sides of the gap. <IMAGE>
Patent DE-69102965-D1 (DE)
Inventor: CIRELLO ALFREDO
IPC: A23L27/21
Filed: 1991-09-23
Granted: 1994-08-25
Abstract: In a method for making a flavouring composition, in particular a composition having a truffle flavour, as a natural base or precursor material for the composition,natural casein is used.
Patent DE-69106486-D1 (DE)
Inventor: CITTERIO GIANFRANCO
IPC: B05B11/02
Filed: 1991-11-08
Granted: 1995-02-16
Abstract: The spray-dispenser device (10) dispenses a dose of liquid medicament contained in a cylindrical vial (18) by the action of a piston (26). The device comprises an operating rod (44) for the piston (26) and a channel (37, 50, 52) for connecting the interior of the vial (18) to a spray nozzle (54). The vial (18) is to be thrown away after dispensing. The vial (18) already contains the piston (26), which seals the vial. The piston (26) is automatically connected to the rod (44) on inserting the vial (18) into the body (11). In the piston there is provided a valve which interrupts the emission channel (37, 50, 52). The valve opens as a result of the operation of the piston (26). <IMAGE>
Patent DE-69116186-D1 (DE)
Inventor: FOLKMAN JUDAH DR
IPC: A61K47/48
Filed: 1991-03-06
Granted: 1996-02-22
Abstract: A method for retaining ophthalmological agents in ocular tissues is provided comprising complexing an ophthalmological drug or reagent with a glucan sulfate such as cyclodextrin sulfate and contacting the complex so formed with the ocular tissue.
Patent DE-69118076-D1 (DE)
Inventor: WHITE STEVEN ANDREW CARL
IPC: C08L101/00
Filed: 1991-06-05
Granted: 1996-04-25
Abstract: The sealing gasket in a beer bottle is formed of a thermoplastic composition that is a homogeneous blend of 20 to 60% by weight butyl rubber and 40 to 80% by weight other thermoplastic polymer. The use of the defined gasket prevents the ingress of volatile odours from the surrounding packaging, allows venting at high pressures and provides a good barrier to oxygen, thereby leading to good storage stability of the beer.
Patent DE-69119235-D1 (DE)
Inventor: GEERTS JAN
IPC: A63C19/00
Filed: 1991-10-15
Granted: 1996-06-05
Abstract: PCT No. PCT/NL91/00202 Sec. 371 Date Feb. 8, 1993 Sec. 102(e) Date Feb. 8, 1993 PCT Filed Oct. 15, 1991 PCT Pub. No. WO92/07142 PCT Pub. Date Apr. 30, 1992The invention relates to a field containing artificial grass consisting of a substructure and a top layer provided thereon, wherein the top layer is a nutrient medium (50) which contains regularly spaced fibers (1) which, when seen in the longitudinal direction of the fiber, extend further into the ground than above the ground, with natural grass (2) seeded between the fibers in a nutrient medium (5) on the substructure (3). The invention also relates to artificial fibers to be used with a field containing artificial grass wherein the fibers have a length of 20 60 cm. The invention further relates to a device for inserting artificial fibers into the ground, said device consisting of one or more planting pins (25), which are disposed perpendicularly to a frame (40), one or more tubes (20) being placed in a sliding frame (41) for supplying the fibers (30) to a location under the planting pin (25).
Patent DE-69123752-D1 (DE)
Inventor: YOUNG THOMAS
IPC: A61M39/02
Filed: 1991-09-13
Granted: 1997-01-30
Abstract: A connector for detachably securing an end of a tube, such as a catheter, to a fluid port of a fluid transfer device, such as an implantable device, the connector having a body part which defines a coupler for coupling to a coupler receiver of the transfer device. The connector includes a sleeve which fits within the body part and defines an aperture for compressively receiving an end of the tube which has been fitted over a fluid port of the transfer device. The body part is rotatable about the sleeve to facilitate coupling of the coupler and coupler receiver. In one embodiment the sleeve has an inner diameter at one end large enough to slide freely over the tube when it is fitted over the fluid port, and the diameter decreases at an intermediate point along the length of the sleeve to provide for compressive axial movement of the tube to form an annular thickness portion of the tube where it abuts the face of the transfer device.
Patent DE-69125926-D1 (DE)
Inventor: ROSTIK LIBOR F
IPC: B21B1/46
Filed: 1991-08-16
Granted: 1997-06-05
Abstract: A continuous process and system for making flat rolled steel or ferrous metal strip having a minimum thickness sufficient to allow substantially direct product manufacture therefrom, wherein a Platzer planetary mill continuously receives an as-continuously cast endless slab of steel or ferrous metal and effects a first reduction in thickness from the as-continuously cast thickness of the slab, a plurality of millstands sequentially receive the continuous strip from the Platzer planetary mill to effect a second reduction in thickness of at least about 50% of the first reduced thickness to provide a continuous strip having an average thickness of less than about 1.8 mm, and electric induction reheaters are placed between each adjacent pair of millstands to maintain the continuous strip at a working temperature sufficient to effect the second reduction in thickness.
Patent DE-69127935-D1 (DE)
Inventor: NADKARNI SURESH RUDRA DR
IPC: C07K7/06
Filed: 1991-07-25
Granted: 1997-11-20
Abstract: Balhimycin, a compound of the molecular formula C66 H73 Cl2 N9 O24 , is a novel Glycopeptide antibiotic.
Patent DE-69210549-D1 (DE)
Inventor: SAMAIN DANIEL
IPC: A23L29/269
Filed: 1992-06-04
Granted: 1996-06-13
Abstract: Particle for use especially as a fat substitute, characterized in that it includes an insoluble hydrophile matrix, surrounded by ahydrophobic layer of fatty acids bound to the matrix by covalent bonds and capable of interacting with lipidic or amphiphilic compounds. The invention also concerns a composition for use as a fat substitute and a process for the preparation of such particles.
Patent DE-69214382-D1 (DE)
Inventor: MANTOVANI MARCO
IPC: B29C48/345
Filed: 1992-08-03
Granted: 1996-11-14
Abstract: The multiple-duct tube for centrifugal separators for blood in particular, suitable for connecting a rotating connector (2) to a stationary connector (4) comprises, in a monolithic structure, a plurality of ducts (12a,12b,12c,12d) which have parallel axes. The outer surface of the tube (1) is defined by blended portions of walls of the peripheral ducts, so as to assume a lobate shape (9a,9b,9c,9d) in a transverse cross-section. <IMAGE>
Patent DE-69225274-D1 (DE)
Inventor: PARR MICHAEL I
IPC: H04W88/02
Filed: 1992-06-23
Granted: 1998-06-04
Abstract: The present invention provides for an equalization method that forms the nucleus of a receiver for digital cellular mobile telephones. A number of distinct aspects of the design are considered novel, including non-real time operation that permits and exploits "time-reversed" equalization to significantly enhance bit error rate performance. The present invention employs the use of a maximum likelihood sequence estimation process. It uses variable coefficient least mean square tracking during estimation of the transmission channel's impulse response. It also employs the use of integrated symbol timing adjustment and carrier tracking algorithms. Time-reversed operation further enhances performance and permits implementation with reasonable complexity of a standards compliant mobile receiver.
Patent DE-69227612-D1 (DE)
Inventor: HIRSCH KENNETH STEVEN
IPC: A61P43/00
Filed: 1992-08-20
Granted: 1998-12-24
Abstract: The invention relates to 1,2,3,4,5,6-hexahydrobenzo[f]quinolin-3-ones, pharmaceutical formulations containing those compounds, and their use as steroid 5 alpha -reductase inhibitors.
Patent DE-69227699-D1 (DE)
Inventor: OETIKER HANS
IPC: F16L33/025
Filed: 1992-02-04
Granted: 1999-01-07
Abstract: A hose clamp (10) with an ear-like structure (12) is adapted to be selectively strengthened to achieve desired holding ability and/or re-tightening forces, as needed. This is achieved by complementary ear-like structures (12a,12b) in the overlapping inner and outer band portions (11a,11b) with the free ends of the inner and outer band portions connected with the corresponding overlapping, respectively, overlapped band portion. In addition or in the alternative, the ear-like structure (12) is strengthened by external and/or internal strengthening members (135) made of spring steel with predetermined spring characteristics. <IMAGE>   <IMAGE>
Patent DE-69228015-D1 (DE)
Inventor: SARMIENTOS PAOLO
IPC: C12N15/866
Filed: 1992-02-28
Granted: 1999-02-11
Abstract: The present invention relates to anti-thrombin polypeptides isolated from the leech Hirudinaria manillensis and to processes for their preparation. The polypeptides of the invention may be modified by way of amino acid extension at either or each end, and may be subjected to post-translational modification. The anti-thrombin polypeptides may be prepared by isolating them from the tissue or secretions of the leech Hirudinaria manillensis but they also may be synthetized by recombinant DNA methods. According to this latter aspect, the invention provides DNA sequences, expression vectors and host cell lines for the recombinant preparation of the polypeptides. The anti-thrombin polypeptides of the invention find an useful application in the treatment of venous thrombosis, vascular shunt occlusion and thrombin-induced disseminated intravascular coagulation. <IMAGE>
Patent DE-69230372-D1 (DE)
Inventor: EMANUELE R
IPC: A61K31/765
Filed: 1992-03-18
Granted: 2000-01-05
Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior an polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
Patent DE-69230769-D1 (DE)
Inventor: SASTRY K
IPC: A61P31/04
Filed: 1992-12-02
Granted: 2000-04-13
Abstract: Use of a composition comprising a peptide of 8 to 24 residues comprising the sequence RAFVTIGK for the preparation of a medicament for the inhibition of HIV.
Patent DE-69230882-D1 (DE)
Inventor: MULLEN A
IPC: A61P31/12
Filed: 1992-06-30
Granted: 2000-05-11
Abstract: The present invention relates to a system comprising a modified bacterial gene for cytosine deaminase that has been engineered into a eukaryotic expression vector and the expression of the gene by mammalian cells. The present invention further relates to methods, gene therapies and vaccines that employ the negative selectable marker, cytosine deaminase, which has the ability to produce a toxic antimetabolic 5-fluorouracil from 5-fluorocytosine.
Patent DE-69232441-D1 (DE)
Inventor: DE MINIAC MICHEL
IPC: C12P7/06
Filed: 1992-10-20
Granted: 2002-04-04
Abstract: The use of any ionophoretic polyether antibiotic in industrial alcoholic fermentation media is described. 0.5-1.5 p.p.m. of such antibiotics prevent bacterial growth and enhance the productivity of alcoholic fermentation using yeast.
Patent DE-69233376-D1 (DE)
Inventor: GOLDSTEIN SHELDON
IPC: C12Q1/56
Filed: 1992-11-12
Granted: 2004-08-05
Abstract: A multiple coagulation test device has a plurality of tubes, each tube having associated coagulation detection means, and containing a treatment dosage of a coagulation enhancing agent. Whole blood samples are placed in the tubes which are mixed and warmed to 37  DEG C, with the time to coagulation determined. The agent giving the lowest clotting time is selected as the most effective treatment for reducing hemorrhaging within a few minutes and the selected treatment begun. Utilizing the inventive device eliminates the need to use a multiple agent approach, by identifying the most effective course of action.
Patent DE-69311318-D1 (DE)
Inventor: BANKS BERNARD JOSEPH
IPC: C07D405/14
Filed: 1993-02-23
Granted: 1997-07-10
Abstract: PCT No. PCT/EP93/00422 Sec. 371 Date Dec. 23, 1994 Sec. 102(e) Date Dec. 23, 1994 PCT Filed Feb. 23, 1993 PCT Pub. No. WO93/18010 PCT Pub. Date Sep. 16, 1993.   <IMAGE>   Benzimidazole anthelmintic agents of formula (I) and their non-toxic salts in which R is H, CO2(C1-C10 alkyl), -CO2(cholester-3-yl) or -CO2(CH2)COOH or -CO2(CH2)nCO2(C1-C6 alkyl), n=1 to 10, R1 is optionally substituted benzoyl, phenyloxy, phenylthio, phenyisulfonyl, phenylsulfinyl, phenylsulfonyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cycloalkylcarbonyl or is selected from a variety of heterocyclic groups and R2 and R3 are independently -CO2(C1-C4 alkyl).
Patent DE-69315945-D1 (DE)
Inventor: ONO KENICHIRO
IPC: G09G3/36
Filed: 1993-09-03
Granted: 1998-02-05
Abstract: A display control apparatus includes a storage unit for storing display data at each position corresponding to a display screen of a display device, a setting unit for setting a read start position of the display data from the storage unit, and a data supply unit for reading out display data in a predetermined amount from the storage unit on the basis of the read start position set by the setting unit and supplying the readout display data to the display device. The read start position set by the setting unit is set on the basis of the display data stored in the storage unit. A display control method is also disclosed. <IMAGE>   <IMAGE>
Patent DE-69400151-D1 (DE)
Inventor: MAZZOLA EZIO
IPC: H04L7/00
Filed: 1994-09-22
Granted: 1996-05-23
Abstract: There is described a method for recovering symbol synchronism useable in the demodulators MPSK or QAM. In accordance with the method in question there is used a VCO inserted in a PLL for sampling the symbols at the double-frequency of the symbol frequency and for generating the symbol reading clock. The algebraic sum with alternating sign of the absolute value of four consecutive samples constitutes a generic term of an error sequence which, appropriately filtered, controls the VCO. The central values of the symbols at the reading instants are obtained by interpolating the respective samples. A hangup of the PLL is revealed by the sign discordance between samples taken in pairs. In case of detection, the sequential order of the interpolated samples is changed and the symbol reading clock phase inverted. The sign of the error sequence controlling the VCO is also inverted in order to stabilise the equilibrium point of the PLL. <IMAGE>
Patent DE-69400245-D1 (DE)
Inventor: SCARZELLO OSVALDO
IPC: B23Q3/155
Filed: 1994-10-12
Granted: 1996-07-18
Abstract: A high speed production unit for performing machining operations, has a first horizontal slide (3), a second slide (6) slidable horizontally along a direction orthogonal to the sliding direction of the first slide (3) and a third vertically sliding slide (9) carrying a tool head (10). In addition to a static tool magazine (50), the unit has a dynamic tool magazine (11) which is displaceable between an operative position adjacent to the working area of the tool head (10) and an inoperative position spaced apart from said working area for replacement of broken or worn tools without any loss in cycle time. <IMAGE>