Patent AU-2016200153-A1 (AU)
Title: Compositions of protein receptor tyrosine kinase inhibitors
Inventor: WU JAY JIE-QIANG
IPC: C07D417/12
Filed: 2016-01-11
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date H(10) International Publication Number 8 July 2010 (08.07.2010) PCT W O 2010/077680 A2 (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 487/04 (2006.01) C07D 403/14 (2006.01) kind of national protection available): AE, AG, AL, AM, C07D 417/12 (2006.01) A61P 29/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, PCT/US2009/067 197 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 8 December 2009 (08.12.2009) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (25) Filing Language: English SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, (26) Publication Language: English TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 61/120,827 8 December 2008 (08.12.2008) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, (71) Applicant (for all designated States except US): VM ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, DISCOVERY INC. [US/US]; 45535 Northport Loop TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, East, 2nd Floor, Fremont, CA 94538 (US). ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventors; and MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, (75) Inventors/Applicants (for US only): WU, Jay Jie- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Quiang [US/US]; c/o VM DISCOVERY INC., 45535 ML, MR, NE, SN, TD, TG). Northport Loop East, 2nd Floor, Fremont, CA 94538 Published: (US). WANG, Ling [CN/US]; c/o VM DISCOVERY - without international search report and to be republished INC., 45535 Northport Loop East, 2nd Floor, Fremont, uo n r io at report R l 48.2(g)) CA 94538 (US). upon receipt of that report (Rule 48.2(g) (74) Agents: LU, Yong et al.; Cooley Godward Kronish LLP, 777 6th Street, N.W., Suite 1100, Washington, DC 20001 (US). o (54) Title: COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS (57) Abstract: The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical composi tions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Relat Ni ed Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such com pounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF recptor TrkA.