Patent AU-2013245536-A1 (AU)
Title: Preparation of isolated agonist anti-EDAR monoclonal antibodies
Inventor: SCHNEIDER PASCAL
IPC: A61K39/395
Filed: 2013-10-18
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date H(10) International Publication Number 7 October 2010 (07.10.2010) PCT W O 2010/113117 A3 (51) International Patent Classification: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, C07K16/28 (2006.01) A61K39/395 (2006.01) DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, IIN, IIR, IIU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (21) International Application Number: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, PCT/I32010/051385 ME, MG, MK, MN, MW, MNX, MY, MZ, NA, NG, NI, (22) International Filing Date: NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, 30 March 2010 (30.03.2010) SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, PCT/1D2009/005118 30 March 2009 (30.03.2009) lB ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, (71) Applicants (for all designated States except US): ED- ES, Fl, FR, GB, GR, HR, HU, IE, IS, IF, LT, LU, LV, IMER BIOTECH S.A. [CH/CH]; Chemin de l'Eglise 7, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, CH-1066 Epalinges (CH). UNIVERSITE DE LAU- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, SANNE [CH/CHJ; Rue du Bugnon 21, CH-1005 Lau- ML, MR, NE, SN, TD, TG). sanne (CH). Declarations under Rule 4.17: (72) Inventors; and - o netrhp(ue41() (75) LnventorslApplicants (for US only): SCHNEIDER, Pas- ofinventorship (Role 4.17(iv) cal [CH/CH]; Chemin des Ormeaux 10, CH-1066 Published: Epalinges (CH). DUNKEL, Nathalie [CH/CH]; Rue An- _ with international search report (Art. 21(3)) cienne 46, CH-1227 Carouge (CH). DEMOTZ, St6phane [CH/CH]; Chemin de l'Eglise 7, CH-1066 - before the expiration of the time limit for amending the Epalinges (CH). claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (74) Agent: KATZAROV S.A.; Rue des Epinettes 19, CH-1227 Geneva (CH). - with sequence listing part of description (Rule 5.2(a)) (81) Designated States (unless otherwise indicated, for every (88) Date of publication of the international search report: kind of national protection available): AE, AG, AL, AM, 14 July 2011 AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (54) Title: PREPARATION OF ISOLATED AGONIST ANTI-EDAR MONOCLONAL ANTIBODIES (57) Abstract: The present invention concerns the preparation of substantially purified agonist anti- EDAR monoclonal antibod ies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention fluther relates to isolated agonist anti- EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-lmked hypoidrotic ectodermal dysplasia and tooth agenesis. The in vention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolat Nq ed monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypo hidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said iso lated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or frag ments thereof.