Patent SG-11201907048U-A (SG)
Title: Low ph pharmaceutical composition comprising t cell engaging antibody constructs
Inventor: MCAULEY ARNOLD
IPC: A61K39/395
Filed: 2018-02-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIP0 I PCT omit IIl °nolo How mu Ho 11011111° oimIE (10) International Publication Number WO 2018/141910 Al W O 20 18/ 1419 10 Al (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/EP2018/052665 (22) International Filing Date: 02 February 2018 (02.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/453,952 02 February 2017 (02.02.2017) US (71) Applicants: AMGEN RESEARCH (MUNICH) GMBH [DE/DE]; Staffelseestrasse 2, 81477 Munich (DE). AM- GEN INC. [US/US]; One Amgen Center Drive, Thousand Oaks, California 91320-1799 (US). (72) Inventors: MCAULEY, Arnold; c/o Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320 (US). GHATTYVENKATAKRISHNA, Pavan; c/o Am- gen Inc, One Amgen Center Drive, Thousand Oaks, Cali- fornia 91320 (US). ABEL, Jeff; 402 Willow Glen Circle, Simi Valley, California 93065 (US). HUH, Joon; c/o Am- gen Inc, One Amgen Center Drive, Thousand Oaks, Cal- ifornia 91320 (US). POMPE, Cornelius; c/o Amgen Re- search (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). KANAPURAM, Sekhar; c/o Amgen Inc, One Am- gen Center Drive, Thousand Oaks, California 91320 (US). TREUHEIT, Michael; 807 Pamela Wood St., Newbury Park, California 91320 (US). JAGANNATHAN, Bharad- waj; 1663 Amarelle St, Thousand Oaks, California 91320 (US). (74) Agent: WEINZIERL, Gerhard et al.; Schiweck Weinzierl Koch, European Patent Attorneys, Landsberger Strasse 98, 80339 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) (54) Title: LOW PH PHARMACEUTICAL COMPOSITION COMPRISING T CELL ENGAGING ANTIBODY CONSTRUCTS (57) : The present disclosure provides a low pH pharmaceutical composition comprising (a) an antibody constructs comprising a first domain binding to a target cell surface antigen, a second domain binding to a second antigen and preferably a third domain, which is a specific Fc modality, (b) at least one buffer agent, (c) at least one saccharide, and (d) at least one surfactant; and wherein the pH of the pharmaceutical composition is in the range of 3.5 to 6.