baber/WOPTO huggingface dataset:
Patent DE-69522960-D1 (DE)
Inventor: PETERS DAN
IPC: C07D211/22
Filed: 1995-12-15
Granted: 2001-10-31
Abstract: PCT No. PCT/EP95/04975 Sec. 371 Date Sep. 4, 1997 Sec. 102(e) Date Sep. 4, 1997 PCT Filed Dec. 15, 1995 PCT Pub. No. WO96/19452 PCT Pub. Date Jun. 27, 1996   <IMAGE>  (I)  Compounds of structure (I) in which R is C1-8alkyl(phenyl)p, C2-8alkenyl(phenyl)p, C2-8 alkenyl(phenyl)p, C3-8cycloalkyl or C1-8alkylC3-8cycloalkyl; p is 0 to 2; n is 0 to 6; A is a bond, oxygen, sulphur or NR1; R1 is hydrogen, C1-8alkylphenylC1-4alkyl; m is 0 to 3; and Ar is aryl or heteroaryl, each of which may be optionally substituted, and salts thereof processes for preparing said compounds, pharmaceutical compositions containing them and their use in therapy, in particular as calcium blocking agents.
Patent DE-69523492-D1 (DE)
Inventor: NAPARSTEK PROF
IPC: G01N33/564
Filed: 1995-02-27
Granted: 2001-12-06
Abstract: The invention provides an immunoassay reagent for the binding and detection of antibodies found in the urine of lupus disease patients, comprising extracellular matrix.
Patent DE-69523645-D1 (DE)
Inventor: WARMAN DAVID J
IPC: G06F3/048
Filed: 1995-08-17
Granted: 2001-12-06
Abstract: The graphical control system of the present invention includes a computer (20), a device interface (35) for a non-computer system device (21) having at least one feature control (29a) (or display (29b)), a bus network (28) connecting the computer (20) to the device interface (35), and a visual network operating system (78) based on an object-oriented programming paradigm. The device interface (35) connects the non-computer system device (21) to the bus network (28) and provides the mechanism for converting computer-generated commands into signals for controlling the operation of the feature control (29a) of the non-computer system device (21). The visual network operating system (78) is a distributed operating system that is partially stored on the computer (20) and partially stored in the device interface (35). A computer portion causes the computer (20) to generate or create a visual device control (40) that graphically replicates the feature control (29a) normally associated with the non-computer system device (21). The visual device control (40) is operated by a conventional graphical control device, such as a mouse (32), track ball, touch screen, joystick, etc. As the replicated controls are operated, the computer (20) sends messages to the device interfaces (35), which cause the feature control (29a) of the non-computer system device (21) to respond in the same way it would have responded had the feature control been operated manually, electrically or effected by another computer on the bus network (28).
Patent DE-69529686-D1 (DE)
Inventor: HOLT ROBERT
IPC: A61K31/44
Filed: 1995-11-27
Granted: 2003-03-27
Abstract: PCT No. PCT/SE95/01415 Sec. 371 Date Nov. 21, 1996 Sec. 102(e) Date Nov. 21, 1996 PCT Filed Nov. 27, 1995 PCT Pub. No. WO96/17076 PCT Pub. Date Jun. 6, 1996Enantiomeric or enantiomerically enriched H+K+ATPase inhibiting pyridinylsulfinyl-benzimidazoles are prepared using microorganisms or microbial enzyme systems to enantioselectively biooxidize corresponding prochiral sulfide compounds and isolating the pharmaceutically active enantiomer or enantiomerically enriched sulfoxide form.
Patent DE-69535886-D1 (DE)
Inventor: AMIRANOFF BRIGITTE
IPC: A61K48/00
Filed: 1995-02-14
Granted: 2009-01-02
Abstract: Polypeptides having galinin receptor activity, genetic material for expressing same, any recombinant cell expressing said polypeptides, and the use thereof, are disclosed.
Patent DE-69606845-D1 (DE)
Inventor: SAMSON GENE
IPC: A61M25/16
Filed: 1996-04-26
Granted: 2000-04-06
Abstract: This is a catheter assembly and a section of that catheter assembly. That catheter assembly may be used in accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the invention is the use of a braided metallic reinforcing member, typically of super-elastic alloy ribbon, situated within the catheter body in such a way to create a catheter having an exceptionally thin wall, controlled stiffness, high resistance to kinking, and complete recovery in vivo from kinking situations. The braid may have a single pitch or may vary in pitch along the axis of the catheter or catheter section. The braided ribbon reinforcing member typically is placed between a flexible outer tubing member and an inner tubing member to produce a catheter section which is very flexible but highly kink resistant. The catheter sections made according to this invention may be used alone or in conjunction with other catheter sections either made using the concepts shown herein or made in other ways. The more proximal sections of the catheter assembly are often substantially stiffer than the more distal sections due to the presence of stiff polymeric tubing or metallic tubing or composited materials in the stiffer section.
Patent DE-69610622-D1 (DE)
Inventor: MIYAGI SHOGO
IPC: A61K31/435
Filed: 1996-04-16
Granted: 2000-11-16
Abstract: The present ophthalmic solution is a pranoprofen ophthalmic solution containing an organic amine. A preferred ophthalmic solution is a 0.01 to 0.5% pranoprofen ophthalmic solution containing 0.1 to 5.0% of the organic amine. The concentration of the organic amine is more preferably 0.5 to 2.5%. A preferred example of the organic amine is tromethamine or 4-(2-hydroxyethyl)-1-(2-sulfoethyl)piperazine. Optionally, 0.002 to 0.01% benzalkonium chloride is added thereto as a preserative. According to the present invention, there can be provided an ophthalmic solution having pranoprofen as an active ingredient, which has no change in composition, excellent stability and little irritation to eyes.
Patent DE-69621402-D1 (DE)
Inventor: BENOIT LOUIS
IPC: A63C1/00
Filed: 1996-09-20
Granted: 2002-07-04
Abstract: The frame (1), having a rectangular inverted U-shaped crosssection with one or more thrust surfaces (3, 4) to receive the sole of a boot, and one or more side flanges (2), is made from a cut-out sheet metal shape, stamped to form curved reinforcing ribs (8) in the flange(s), and then folded. The flanges have fixing holes (6) for blade, wheels or rollers, and the frame can be made from a number of components joined by screws, rivets or welding.
Patent DE-69621822-D1 (DE)
Inventor: MONTEZINOS LEE
IPC: A23F3/14
Filed: 1996-12-09
Granted: 2002-07-18
Abstract: A beverage such as a dilute juice or tea beverage having a stable flavor/cloud emulsion which contains from about 0.005 to about 0.04% gellan gum, from about 100 ppm to about 1000 ppm of a preservative selected from sorbic acid, benzoic acid, alkali metal salts thereof and mixtures thereof, from about 300 ppm to about 3000 ppm of a food grade water soluble polyphosphate, and from about 60 to about 99% by weight of added water having from 0 ppm to about 180 ppm of hardness.
Patent DE-69634747-D1 (DE)
Inventor: MCGUIGAN CHRISTOPHER
IPC: A61P31/18
Filed: 1996-03-13
Granted: 2005-06-23
Abstract: Aryl substituted phosphoryl derivatives of the formula In which Ar is phenyl, naphthyl, or pyridyl, Y is O or S, X<SUP>1 </SUP>is O, NR<SUP>3</SUP>, S, CR<SUP>3</SUP>R<SUP>4</SUP>, CR<SUP>3</SUP>W<SUP>1 </SUP>or CW<SUP>1</SUP>W<SUP>2</SUP>, X<SUP>2 </SUP>and X<SUP>6 </SUP>are a bond or X<SUP>6 </SUP>is CH<SUB>2 </SUB>and X<SUP>2 </SUP>is O, NR<SUP>3</SUP>, S, CR<SUP>3</SUP>R<SUP>4</SUP>, CR<SUP>3</SUP>W<SUP>1 </SUP>or CW<SUP>1</SUP>W<SUP>2</SUP>, R<SUP>3 </SUP>and R<SUP>4 </SUP>are H, alkyl or phenyl, groups, W<SUP>1 </SUP>and W<SUP>2 </SUP>are heteroatoms, X<SUP>3 </SUP>is alkylene, X<SUP>4 </SUP>is oxygen or CH<SUB>2</SUB>, X<SUP>5 </SUP>is a bond or CH<SUB>2</SUB>, Z is O, NR<SUP>5</SUP>, S, alkyl or phenyl, R<SUP>5 </SUP>is H, alkyl or phenyl, J is H, alkyl, phenyl, or a heterocyclic or polycyclic group, Q is O, NR<SUP>6</SUP>, S, CR<SUP>6</SUP>R<SUP>7</SUP>, CR<SUP>6</SUP>W<SUP>3 </SUP>or CW<SUP>3</SUP>W<SUP>4</SUP>, R<SUP>6 </SUP>and R<SUP>7 </SUP>are H, alkyl or phenyl, and W<SUP>3 </SUP>and W<SUP>4 </SUP>are hetero atoms, T<SUP>1 </SUP>and T<SUP>2 </SUP>are H or CH<SUB>2</SUB>R<SUP>8</SUP>, R<SUP>8 </SUP>is H, OH or F, or T<SUP>1 </SUP>and T<SUP>2 </SUP>together are -CH-CH- or -C(R<SUP>9</SUP>)(R<SUP>10</SUP>)C(R<SUP>11</SUP>)(R<SUP>12</SUP>)-, R<SUP>9 </SUP>is H, halogeno, CN, NH<SUB>2</SUB>, CO-alkyl, or alkyl, R<SUP>10</SUP>, R<SUP>11</SUP>, and R<SUP>12 </SUP>are H, N<SUB>3</SUB>, halogen, CN, NH<SUB>2</SUB>, CO-alkyl, or alkyl, and B is a purine or pyrimidine base, have antiviral activity, as for example against HIV. Particularly preferred are thymine and adenine derivatives of amino acid phenoxyphosphoroamidates. A typical embodiment is 2',3'-dideoxy-2',3'-didehydrothymidine 5'-(phenyl methoxy alaninyl) phosphoroamidate which can be prepared from phenyl methoxy alaninyl phosphorochloridate and 2',3'-dideoxy-2',3'-didehydrothymidine.
Patent DE-69703509-D1 (DE)
Inventor: GOMI TATSUYA
IPC: B67D1/04
Filed: 1997-04-11
Granted: 2000-12-21
Abstract: A spear tube (1) comprises a body connected with a keg neck interface (3) of the beer keg (2). A gas valve (13), a down tube (5) and a beer valve (4) installed in the down tube are fittingly connected to the body. A stopper (20) prevents the spear tube (1) from popping out from the beer keg during detaching operation. A stopper portion (23) of the stopper (20) is formed protruding in the obliquely upward direction to penetrate a side hole (4c) of the body and has a cross-section of a predetermined curvature shape. Therefore, the stopper functions to prevent the popping-out of the spear tube and provides improved durability. <IMAGE>
Patent DE-69704731-D1 (DE)
Inventor: NORMAN BRYAN HURST
IPC: C07D273/02
Filed: 1997-02-26
Granted: 2001-06-13
Abstract: The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the novel cryptophycin compounds. The compounds are of the formula <CHEM>  wherein   Ar is phenyl or any simple unsubstituted or substituted aromatic or heteroaromatic group; R<1> is halogen, SH, amino, monoalkylamino, dialkylamino, trialkylammonium, alkylthio, dialkylsulfonium, sulfate, or phosphate;     R<2> is OH or SH; or R<1> and R<2> may be taken together to form an epoxide ring, and aziridine ring, an episulfide ring, a sulfate ring, or monoalkylphosphate ring; or R<1> and R<2> may be taken together to form a second bond between C18 and C19;   R<3> is a lower alkyl group;   R<4> is H;   R<5> is H; R<4> and R<5> may be taken together to form a second bond between C13 and C14; R<6> is benzyl, hydroxybenzyl, alkoxybenzyl, halohydroxybenzyl, dihalohydroxybenzyl, haloalkoxybenzyl, or dihaloalkoxybenzyl group;   R<7> is H or a lower alkyl group;   R<8> is H or a lower alkyl group; or R<7> and R<8> may optionally be taken together to form a cyclopropyl ring; R<9> is selected from the group consisting of H, a lower alkyl group, (C1-C3) alkylaryl, and aryl; R<10> is selected from the group consisting of H, a lower alkyl group, (C1-C3) alkylaryl, and aryl; R<11> is H; simple alkyl; phenyl, substituted phenyl, benzyl, substituted benzyl;   X is O, NH or alkylamino;   Y is C, O, NH, S, SO, SO2 or alkylamino; and a pharmaceutically acceptable salt or solvate thereof.
Patent DE-69709050-D1 (DE)
Inventor: PONTIER RENAUD
IPC: B01J8/12
Filed: 1997-09-16
Granted: 2002-01-24
Abstract: PCT No. PCT/FR97/01630 Sec. 371 Date Aug. 19, 1998 Sec. 102(e) Date Aug. 19, 1998 PCT Filed Sep. 16, 1997 PCT Pub. No. WO98/12280 PCT Pub. Date Mar. 26, 1998A process is described for catalytic cracking of a petroleum feed in which a catalyst from a regeneration zone 4 is caused to flow in a dense fluidized bed conditioning zone 2 upstream of an injection zone 10, the fluidization rate being 0.1 to 30 cm/s. The throughput of catalyst into injection zone 10 is regulated by a constriction means 11. The hydrocarbon feed 12 is injected below the constriction means and flows counter-current to the direction of flow of the shaped catalyst flow. The hydrocarbon feed 12 is injected at a set injection angle depending on the movement of the feed and the catalyst.
Patent DE-69710468-D1 (DE)
Inventor: BENEDETTI YANNICK
IPC: C07H17/08
Filed: 1997-05-13
Granted: 2002-03-21
Abstract: PCT No. PCT/FR97/00840 Sec. 371 Date Nov. 11, 1998 Sec. 102(e) Date Nov. 11, 1998 PCT Filed May 13, 1997 PCT Pub. No. WO97/43297 PCT Pub. Date Nov. 20, 1997An isomerization method wherein a compound of formula wherein X and y together form a 3-oxo radical, or X is a hydrogen atom and Y is either a radical a where R2 is OH or O-acyl, or an O-alkyl or NH2 radical; R1 is a hydrogen atom or a methyl radical; Z is hydrogen or an acyl radical; and R is a hydrogen atom, an NH2 radical or a (CH2)nAr, NH(CH2)nAr or N=CH(CH2)nAr radical, in the form of a 10 alpha  isomer or a mixture of 10 alpha  and 10 beta  isomers, is exposed to a basic agent to give the corresponding compound of formula I in which the 10-methyl radical is in the  beta  position.
Patent DE-69714282-D1 (DE)
Inventor: NANNINI OSVALDO
IPC: B60M1/26
Filed: 1997-10-31
Granted: 2002-08-29
Abstract: A device for compensating length variations of tensioned cables, with a substantially constant tension, including a contrast element, which is meant to be interposed between one end of the tensioned cable and an anchoring element and is adapted to generate an elastic reaction which can vary as a function of the length variation of the cable. The device includes elements for connecting the contrast element to the cable which are suitable to convert the elastic reaction of the contrast element into a substantially constant tension applied to the cable, regardless of its length, over a preset length variation range.
Patent DE-69725445-D1 (DE)
Inventor: GRABAU PETER
IPC: F03D80/40
Filed: 1997-07-03
Granted: 2003-11-13
Abstract: For avoiding icing of windmill wings of composite materials, use is made of microwave energy for heating of the composite material itself, this energy preferably being supplied from interior, fixedly mounted microwave generators in response to detection of potential climatic conditions for icing to occur. The wing surface can be coated with a layer reflecting the microwaves, whereby these may propagate by reflections through and between the shell parts of which the wing will normally consist. It is possible to arrange for selective heating by the use of more generators, which may then, each, be of the type that is already in production with modest size and at low costs for use in ordinary microwave ovens.
Patent DE-69729299-D1 (DE)
Inventor: IGUCHI SEIICHIRO
IPC: A61J1/16
Filed: 1997-06-13
Granted: 2004-07-01
Abstract: The invention provides a bicarbonate-containing medical solution package comprising a gas-permeable plastic container holding a bicarbonate-containing medical solution and a gas-impermeable plastic packaging member accommodating the gas-permeable plastic container, with a carbon dioxide atmosphere having been established in a space defined by the container and packaging member and the space containing a pH indicating device comprising a gas-permeable plastic packet containing a bicarbonate-containing fluid (similar to the medical solution) and a pH-indicator having the property to undergo a change in color in response to a change in pH of the fluid. With this package, the change in pH and consequent aging of the medical solution due to prolonged storage or a trouble such as the incidence of a pinhole in the outer packaging member can be easily ascertained by the naked eye. <IMAGE>
Patent DE-69730852-D1 (DE)
Inventor: BASTIOLI CATIA
IPC: C08K5/00
Filed: 1997-11-05
Granted: 2004-10-28
Abstract: Polymeric compositions comprising thermoplastic starch and a thermoplastic polymer incompatible with starch, in which the starch constitutes the dispersed phase and the thermoplastic polymer constitutes the continuous phase, selected:A) from compositions comprising an agent with an interfacial effect selected from esters of polyols with mono- or polycarboxylic acids with dissociation constants within certain limits, the esters having specific values of the hydrophillic/lipophilic balance index HLB or being amongst the non-ionic surfactants which are soluble in water but cannot significantly be extracted by water from the compositions which contain them,B) from compositions wherein the thermoplastic polymer is an aliphatic or aliphatic-aromatic copolyester wherein the ratio R between the average viscometric molecular weight and the melt index is greater than 25,000 andC) from compositions wherein the thermoplastic polymer is selected from aliphatic-aromatic copolyesters, polyester-amides, polyester-ethers, polyester-ether-amides, polyester-urethanes and polyester-ureas and wherein the compositions are obtained by extrusion of the component maintaining a water content during the mixing stage from 1 to 5% by weight.
Patent DE-69732858-D1 (DE)
Inventor: GRIMES JAMES B
IPC: A61B10/02
Filed: 1997-08-13
Granted: 2005-04-28
Abstract: A femoral head-neck prosthesis (1) which allows natural straining of the upper femur to prevent bone loss. The natural angle of loading of the bone is determined prior to the operation, and the prosthesis is implanted with its longitudinal axis (AX-1) parallel to the natural angle (AX-5). The prosthesis is constructed to inhibit axial fixation and "splinting" of the prosthesis below the interface between the femur neck and the prosthesis on the upper femur. Splines (19) on a stem (13) of the prosthesis help to fix the prosthesis against rotation and toggling motion. The prosthesis is asymmetrical about its longitudinal axis to provide further stability when implanted. The prosthesis and its method of implantation preserve the trochanter and cap the femur to prevent microscopic debris from entering the interior bone.
Patent DE-69736692-D1 (DE)
Inventor: MIXSON ARCHIBALD JAMES
IPC: A61K38/17
Filed: 1997-07-16
Granted: 2006-11-02
Abstract: Cationic vehicles:DNA complexes comprising DNA encoding anti-angiogenic peptide or DNA encoding a tumor suppressor protein and DNA encoding an anti-angiogenic peptide, as well as their use in gene therapy, are disclosed. <IMAGE>
Patent DE-69737309-D1 (DE)
Inventor: HERBOTS IVAN MAURICE
IPC: C07F13/00
Filed: 1997-07-09
Granted: 2007-03-22
Abstract: The present invention relates to cleaning compositions, including laundry, dishwashing, hard surface cleaner, oral/dental cleaning compositions, comprising a proteinic substrate based oxygenase, which provide effective and efficient cleaning of proteic based stains and/or soils such as protein containing food stains/soils and everyday body soils and provide sanitisation of the treated surfaces. Furthermore, the cleaning compositions of the present invention provide fabric realistic items cleaning and whitening performance when formulated as a laundry detergent composition.
Patent DE-69737772-D1 (DE)
Inventor: MARSHAL JULIAN
IPC: G06K9/00
Filed: 1997-07-22
Granted: 2007-07-12
Abstract: A user interface for facilitating the input of films into a computer-aided diagnosis system is disclosed. The user interface includes a scanner which receives and scans the film-based images, and a film feeder which holds and transports them to the scanner. A touch sensitive display screen is provided to display status information to and receive instructions from an operator. The display screen displays miniature images of the films having color-coded borders so that the operator monitors the processing of the films. The interface also includes a bar code reader and allow the operator to conduct procedures for testing the scanner.
Patent DE-69802787-D1 (DE)
Inventor: KUZNICKI M
IPC: C01B39/50
Filed: 1998-03-06
Granted: 2002-01-17
Abstract: This invention relates to zeolitic molecular sieve compositions characterized by outstanding capability to complex multivalent cations, especially calcium. In particular, the invention relates to novel zeolitic molecular sieve compositions, especially those based on molecular sieves having a high alumina-to-silica ratio, in which crystals of the zeolite are modified by the inclusion of occluded silicate.
Patent DE-69810004-D1 (DE)
Inventor: GELLERT JOBST ULRICH
IPC: B29C45/26
Filed: 1998-04-20
Granted: 2003-01-23
Abstract: Multi-cavity injection moulding apparatus has spaced first and second heated manifolds (12,14) interconnected by an elongated connector bushing (22) all mounted in a mould having a melt passage (10) extending from the first manifold through the bushing into the second manifold. The bushing has an elongated main body (48), through which a melt bore (63) extends, having a non-threaded, cylindrical portion (56) extending from one end and a threaded, cylindrical portion (52) extending from the opposite end. The threaded portion is received in a threaded cylindrical opening aligned with a melt passage in the second heated manifold and the non-threaded portion is received in a non-threaded opening aligned with the melt passage in the first heated manifold, the non-threaded opening having an inner end with a circular shoulder (64) extending into the melt passage. The end of the main body of the connector bushing abuts against the circular shoulder. It also has a cylindrical outer sleeve (50) which fits around its non-threaded cylindrical portion and in the non-threaded opening in the first manifold. The main body of the bushing is made of a material having sufficient strength to push the two manifolds further apart due to thermal expansion as the parts are heated to a predetermined operating temperature. The cylindrical outer sleeve is made of a material having sufficient coefficient of expansion to expand to form a seal to prevent melt leakage around the non-threaded cylindrical portion as the parts are heated.
Patent DE-69815341-D1 (DE)
Inventor: GREEN JIM
IPC: A61B17/17
Filed: 1998-05-22
Granted: 2003-07-10
Abstract: A surgical drilling guide for guiding a drilling tool, measuring its penetration depth, and protecting surrounding tissue. The guide has a sleeve and a plunger that telescopes within the sleeve. The plunger and the sleeve have axial bores adapted to slidably receive a portion of the tool that protrudes beyond a drill chuck. The extended length of the drilling guide is substantially as long as the length of the protruding portion of the tool, and a maximum extended length of the guide is preferably as long as the protruding portion. As the tool in drilled into a workpiece, the chuck collapses the drilling guide. Gradations on the side of the guide indicate workpiece-penetration depth.
Patent DE-69816656-D1 (DE)
Inventor: SUHONEN CHRISTOPHER
IPC: A61C15/04
Filed: 1998-12-09
Granted: 2003-08-28
Abstract: The nylon fiber strand is coated with a coating to produce a coated surface on the nylon that mimics the surface characteristics of polytetrafluoroethylene (PTFE). The coating is comprised of a base prime coat and a top finish coat. These coatings are applied separately to the nylon fiber strand. The top finish coat which is also known as the nylon wax coat is comprised of waxes, an ester and a silicone, and primarily of waxes. The waxes are comprised of a mixture of a low melting point wax and a high melting point wax.
Patent DE-69817177-D1 (DE)
Inventor: WOOLARD LESLIE ADRIAN ALFRED
IPC: F21S2/00
Filed: 1998-06-03
Granted: 2003-09-18
Abstract: A method for furnishing a perceptor with apparently continuous illumination over an extended target area, in which at any instant only part of said area is illuminated, but every part thereof is intermittently and repeatedly illuminated by discontinuous flashes. With regard to any one part of said target area, the flashes are repeated at time intervals not less than the decay period of the response elicited in the perceptor.The method is performed by means of a device which comprises a beam-generating arrangement (1) that focuses a beam of radiation (5) upon a rotatably-mounted light-deflector (6), which is rotated under control at a suitably high speed by mechanical means (9, 10, 11 and 12) so as repeatedly to illuminate a target area (15) with a narrow flash to radiation (16).