baber/WOPTO huggingface dataset:
Patent DK-0720601-T3 (DK)
Inventor: KALINDJIAN SARKIS BARRET
IPC: A61K31/415
Filed: 1994-08-09
Granted: 2000-11-20
Abstract: Compounds of formula (Ia), (Ib), or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R1(m) represents up to 6 substituents, K represents -O-, -S-, -CH2-, -N(R2)- or -N(COR2)-, in which R2 is H or C1 to C3 alkyl, W is a carbonyl, sulfonyl or sulfinyl group, provided that at least one of W and X contains carbonyl, Y and Z are as given in the description, and their pharmaceutically acceptable salts are ligands at CCK and/or gastrin receptors.
Patent DK-0725794-T3 (DK)
Inventor: ROLLINS BARRETT
IPC: C12N1/21
Filed: 1994-11-07
Granted: 2001-12-10
Abstract: The invention relates to a human MCP-1 derivative, and pharmaceutical compositions thereof, wherein human MCP-1 has been modified such that the protein inhibits monocyte chemoattractant activity. Successful inhibition of the activity is found where the MCP-1 is modified in one or more of the following: a) the 28-tyrosine is substituted by aspartate, b) the 24-arginine is substituted by phenylalanine, c) the 3-aspartate is substituted by alanine, and/or d) the 2-8 amino acid sequence is deleted. The claimed MCP-1 derivatives can be administered to a patient in need of inhibiting MCP-1 monocyte chemoattractant activity. For example, the derivatives can be used to prevent restenosis, such as that which is common in a patient undergoing coronary artery angioplasty. The invention further relates to compositions and methods of inhibiting monocyte chemoattractant activity of MCP-1 employing the derivatives described.
Patent DK-0771263-T3 (DK)
Inventor: DIBLER WALTER
IPC: B29C51/16
Filed: 1995-06-27
Granted: 1999-06-14
Abstract: PCT No. PCT/EP95/02505 Sec. 371 Date Mar. 10, 1997 Sec. 102(e) Date Mar. 10, 1997 PCT Filed Jun. 27, 1995 PCT Pub. No. WO96/02378 PCT Pub. Date Feb. 1, 1996The present invention relates to a method for providing at least one insertion label on a tool of a machine, the insertion label being insertable into a mold half of a tool of a plastics processing machine, in particular injection molding machine or deep-drawing machine. In this method insertion labels are punched out of label web material by means of a punching device consisting essentially of a punching plate and a cutting tool. The insertion labels are transferred by a carrier, which belongs to the punching device, to the tool of the machine and are discharged for insertion thereinto. So far a great problem has consisted in performing such a transfer in such a manner that the insertion label is positioned in a sufficiently precise manner without creases. This problem is overcome in that after the punching operation the insertion labels are held by the punching plate which is movable substantially in a direction transverse to the punching direction and formed as a carrier, and are transferred to the tool of the machine. Furthermore, the present invention relates to an apparatus for performing the method.
Patent DK-1003443-T3 (DK)
Inventor: SEARE WILLIAM J JR
IPC: A61F2/02
Filed: 1995-10-25
Granted: 2004-05-10
Abstract: A porous implant and method of making such is disclosed. A mold form material (164) is created by adhering solid particles together to form a porous network. A liquid phase of a final product is forced through the interstices of the mold form (164), and then most of the liquid material is forced out of the interstices leaving a thin coat (162). Next, the thin coat is cured to produce a thin coat of a polymer such as silicone rubber (162). Next, the mold form material (164) is dissolved out creating a porous structure containing only the cured polymer.
Patent DK-0879097-T3 (DK)
Inventor: LARSEN LEIF STEEN
IPC: B05C7/00
Filed: 1996-05-31
Granted: 2002-07-22
Abstract: A method for washing the interior surfaces of tanks with a washing head is provided with a nozzle (28) which ejects a liquid beam and which is rotatable about a first (11) and a second (34) axis whereby the nozzle is allowed to cover a two-dimensional solid angle. The washing head is controlled in such a manner that for an entire revolution about the first axis, the nozzle performs a small rotation about the second axis, and that over a number of revolutions about the first axis the nozzle follows a path which covers the entire a solid angle. The drive mechanism for rotating the washing head is arranged externally of the conduits carrying washing liquid in order to avoid loss of washing pressure and wear of the drive mechanism. According to the invention the movement of the nozzle along the defined path is monitored and the result of the monitoring is utilised to control the energy density of the beam in order that it is reduced when the beam is directed at the zones which do not require the maximum energy.
Patent DK-0828560-T3 (DK)
Inventor: WARNER BRIAN D
IPC: B01L3/00
Filed: 1996-05-29
Granted: 2002-10-14
Abstract: A cover effective to releasably seal a multiwell container, such as a microtitration plate, is disclosed. The cover contains a pad, fashioned from a flexible polymer sheet, and a plurality of resiliently compressible ridges formed on the sheet. The ridges are deformable, such that application of pressure applied to the cover is effective to form a fluid-tight seal between the pad and the well openings. The ridges extend from the pad sufficiently to break the seal upon release of the pressure.
Patent DK-0847663-T3 (DK)
Inventor: AZIMA HENRY
IPC: H04R1/22
Filed: 1996-09-02
Granted: 1999-09-27
Abstract: A vehicle such as an aircraft, railway carriage, motor coach or ferry having a passenger compartment [102] has a loudspeaker within the passenger compartment. The loudspeaker [81] comprises a distributed mode acoustic radiator [2] with a transducer [9] mounted wholly and exclusively on the radiator to vibrate the radiator to cause it to resonate. The seat backs within the passenger compartment are shells moulded from a suitable plastic material. These moulded seat backs form the frame for the loudspeakers and include a groove which effectively defines a resilient suspension for them.
Patent DK-0848596-T3 (DK)
Inventor: BRINDA PAUL D
IPC: A61B5/15
Filed: 1996-09-06
Granted: 2004-04-05
Abstract: A sampling apparatus for interstitial fluid includes a pressure ring surrounding a collection needle. The pressure ring and needle are movable relative to one another for the ring to first engage a patient's skin surface prior to insertion of the needle.
Patent DK-0796853-T3 (DK)
Inventor: PLAUM MARCUS JOSEPH MARIA
IPC: C07D281/10
Filed: 1997-03-17
Granted: 2000-06-26
Abstract: Process for the preparation of a 1,5-benzothiazepine derivative, or a salt thereof, of formula 1 where R1 represents H, an alkyl group or an alkoxy group and R2 represents H or a halogen, in which process a propanoic acid derivative of formula 2 where R1 and R2 are as defined above and R3 represents H or an alkyl group is subjected to an intramolecular cyclisation reaction in a non-halogenated solvent in the presence of a carboxylic acid. Preferably, R2 is H and R1 is OCH3. Trichloroacetic acid is preferablky used as  alpha -chlorinated acid.   The benzothiazepine obtained on cyclisation can be subjected to an alkylation reaction and/or an acylation reaction to obtain known pharmaceutical products, in particular diltiazem. <CHEM>
Patent DK-0946248-T3 (DK)
Inventor: OBST YURI
IPC: B01D29/01
Filed: 1997-12-01
Granted: 2003-11-10
Abstract: A filter system (10) comprising a filter medium (11) for filtering contaminants from a process fluid, having a filtration side on which contaminants collect and a filtrate side from which filtrate flows; a counter-flow generator (20) located on the filtrate side that directs a localized stream of counter-flow fluid (23) from the filtrate side to the filtration side of the filter medium (11) to thereby dislodge the contaminants from the filtration side of the filter medium (11), wherein the localized stream (23) traverses a substantial proportion of the filter medium (11). The filter system (10) optionally further comprises a clearing-flow generator (30) or like means located on the filtration side of the filter medium (11) which clears contaminants from the filter medium (11).
Patent DK-0914129-T3 (DK)
Inventor: ISLAM KHALID
IPC: A61P29/00
Filed: 1997-04-23
Granted: 2002-01-28
Abstract: PCT No. PCT/EP97/02049 Sec. 371 Date Oct. 26, 1999 Sec. 102(e) Date Oct. 26, 1998 PCT Filed Apr. 23, 1997 PCT Pub. No. WO97/41862 PCT Pub. Date Nov. 13, 1997Use of a compound of formula (I) wherein R represents hydrogen or chlorine, for preparing an immunosuppressive medicament.
Patent DK-0895744-T3 (DK)
Inventor: BUSCHER THOMAS
IPC: A47L9/14
Filed: 1998-07-22
Granted: 2003-12-22
Abstract: The detection device has a sensor for detecting the auxiliary filter and a switching device controlled by the sensor for preventing the vacuum cleaner from being switched on if the filter is not detected correctly. At least one sensitive element (5) in or on the filter (1) is detected using electromagnetic waves. An evaluation device detecting the correct filter position is connected to the switching device
Patent DK-0915278-T3 (DK)
Inventor: KORTE HERMANN
IPC: E03D1/34
Filed: 1998-11-02
Granted: 2004-02-09
Abstract: The valve seal fitting has a closing member (1) against which a radially projecting sealing element (3) is held in an annular groove (10). The sealing element is also against a valve seat (2) of larger diameter. The annular region has one or more overflow channels, possibly formed by radial U-shaped ribs (101). The sealing element is held with little axial movement against the sealing edge (11) on the closing member. There are one or more throttle channels (4) of smaller diameter than the overflow channels downstream of the sealing element.
Patent DK-0928948-T3 (DK)
Inventor: HELANDER JYRKI
IPC: F42B12/18
Filed: 1998-01-06
Granted: 2003-08-25
Abstract: This invention concerns a device, such as a shell Ä1Ü or the like, with at least a first charge unit and a second charge unit Ä2Ü, Ä6Ü arranged in series one after the other. The charge units include one RSV charge Ä3Ü, Ä7Ü each. The charges are designed to be detonated one after the other with a time separation between the detonations. In order to suppress the interference to an undetonated charge by a shock wave generated by the detonation of a previously detonated charge, the joint Ä12Ü that connects the charge units Ä2Ü, Ä6Ü has been designed in a special way. According to the invention the joint includes a sprung damping section Ä13Ü, parallel to the longitudinal axis of the device, that mechanically fastens together the two charge units. In addition a rigid support device Ä22Ü is connected to the damping section Ä13Ü and dimensioned so that when the damping section is in an unstressed state there is a clearance Ä23Ü in the longitudinal axis of the device between the two charge units Ä2Ü, Ä6Ü. <IMAGE>
Patent DK-0986570-T3 (DK)
Inventor: MYHREN FINN
IPC: A61P31/12
Filed: 1998-01-23
Granted: 2003-07-28
Abstract: The invention provides Gemcitabine esters or amides in which the 3'- and/or 5'-OH group and/or the N4-amino group is derivatised with a C18- and/or C20-saturated or mono-unsaturated acyl group, preferably an acyl group selected from oleoyl, elaidoyl, cis-eicosenoyl and trans-eicosenoyl. The Gemcitabine esters and amides are useful as anti-cancer and anti-viral agents.
Patent DK-1003749-T3 (DK)
Inventor: RATKAI ZOLTAN
IPC: A61P25/06
Filed: 1998-08-07
Granted: 2004-03-08
Abstract: The disclosure relates to a novel 8-substituted-9H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine compound of formula I and pharmaceutically acceptable quaternary ammonium salts thereof, a process for preparing the same, a pharmaceutical composition containing a 8-substituted-9H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine compound, and a method of treatment using the pharmaceutical composition. A complete description of the compound of formula I is found in the specification. The compounds of the general formula I possess unique competitive AMPA/kainite antagonist properties making them useful in the treatment of diseases where inhibition of the AMPA/kainite receptors may a favorable effect.
Patent DK-1042492-T3 (DK)
Inventor: STINSON JEFFREY R
IPC: A61K38/00
Filed: 1998-12-22
Granted: 2010-01-18
Abstract: The present invention describes the preparation and use of biologically and immunologically active humanized monoclonal antibodies to Shiga toxin, a toxin associated with HC and the potentially life-threatening sequela HUS transmitted by strains of pathogenic bacteria. The present invention describes how these humanized antibodies may be used in the treatment or prevention of Shiga toxin induced diseases. One aspect of the invention is the humanized monoclonal antibody which binds Shiga toxin where the constant regions are IgG1-kappa and the variable regions are murine in origin. Yet another aspect of the invention is expression vectors and host cells transformed with such vectors which express the humanized monoclonal antibodies of the present invention.
Patent DK-1103481-T3 (DK)
Inventor: DE GUGLIELMO PASCAL
IPC: B65D71/00
Filed: 1999-10-08
Granted: 2004-12-13
Abstract: Package (2) is folded from a pre-cut carton board sheet. The bottom (F) is limited by two side walls (6) and flanges (R). Each flange has a central portion (14) and two curved portions (16) extending from it, the end portions (15) being folded against the internal face (38) of the side wall. Independent claims are included for carton board sheet and the storing assembly.
Patent DK-1137731-T3 (DK)
Inventor: AEHLE WOLFGANG
IPC: C09D197/00
Filed: 1999-12-03
Granted: 2006-03-27
Abstract: A method is provided for producing a painted article comprising: (a) preparing a lignin solution comprising lignin and a dye or pigment; (b) mixing the lignin solution with a phenol oxidizing enzyme; (c) incubating the mixture from said step (b) under conditions and for a time sufficient to form a solution of a desired viscosity; (d) contacting or spreading the mixture from the step (c) on an article to be painted; and (e) allowing the mixture to set onto the article by subjecting the article to conditions and for a time sufficient to form a paint on the surface of the article.
Patent ES-2244367-T3 (ES)
Inventor: MILSTEIN SAM J
IPC: A61K38/095
Filed: 1994-04-22
Granted: 2005-12-16
Abstract: The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form durg containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
Patent ES-2212937-T3 (ES)
Title: Sistema de medicion y de control para la regulacion transversal de vehiculos sucesivos entre si y procedimiento para este sistema.
Inventor: BOTTIGER FRIEDRICH
IPC: B62D6/00
Filed: 2000-02-26
Granted: 2004-08-16
Abstract: Sistema de medición y de control para la guía de un vehículo durante una conducción de seguimiento, en la que el vehículo - como vehículo remolcado (1) - le sigue al vehículo de guía (10), que precede a éste; sistema éste que posee: ¿ Un dispositivo medidor (25) para medir la distancia de vehículos (d) entre el vehículo de seguimiento (1) y el vehículo de guía (10); ¿ Una unidad de regulación y de control (3) para la generación de unas señales de ajuste (U) en función de las señales de medición del dispositivo medidor (25); en este caso, las señales de ajuste (U) son empleadas para el ajuste de una parte componente del vehículo de seguimiento (1), y es producida una señal de dirección (U) como la señal de ajuste para la guía transversal del vehículo de seguimiento (1); Sistema éste que está caracterizado porque ¿ Dentro del dispositivo medidor (25) es determinado - como una señal de medición adicional - el ángulo de remolque (micra) entre el vehículo de seguimiento (1) y el vehículo de guía(10), el cual se produce - al pasar el vehículo por una curva o en el caso de un desplazamiento lateral entre el vehículo de guía (10) y el vehículo de seguimiento (1) - como el ángulo entre el eje longitudinal (17) del vehículo de seguimiento (1) y una línea de unión, que se extiende desde el eje delantero (12) del vehículo de seguimiento (1) hasta el eje posterior del vehículo de guía (10); así como caracterizado porque ¿ La unidad de regulación y de control (3) determina la señal de dirección (U) como una relación, que está en función del ángulo de remolque (micra) y según la prescripción de U = fkt * micra; en este caso, fkt representa una función, que depende de la distancia de vehículos (d).
Patent ES-2222870-T3 (ES)
Title: Reja de sembrar.
Inventor: WODRICH TIMOTHY DIRK
IPC: A01C5/06
Filed: 2000-05-06
Granted: 2005-02-16
Abstract: Reja de sembrar (24) para una máquina sembradora, con una pieza superior (26), que está preparada para ser acoplada a un tubo de alimentación de semillas (22) y dispone de un canal de semillas (30) superior, y con una pieza inferior (28), que se puede fijar a la pieza superior (26) y está provista de un canal de semillas inferior, el cual está acoplado al canal de semillas (30) superior y está preparado para recibir semillas de la pieza superior (26), caracterizada porque la pieza inferior (28) está provista de un rebaje (72) colindante con la pieza superior (26), el cual da cabida a una lengüeta (70) que comprime las semillas, que se extiende hacia atrás y abajo detrás del canal de semillas inferior, con lo que la lengüeta (70) está inmovilizada entre la pieza superior (26) y la pieza inferior (28).
Patent ES-2206105-T3 (ES)
Inventor: BECHER MICHAEL
IPC: H01H37/32
Filed: 2000-05-27
Granted: 2004-05-16
Abstract: An excess temperature safety device (16) has a hot plate with a hot substrate (12) and is wired up electrically in series to an appliance, in order to shut off its voltage supply if excess temperature occurs. The excess temperature safety device carries a switch (19) to be fitted on an appliance but removable and dependent on temperature. This switch has a switch-back temperature below room temperature.
Patent ES-2261123-T3 (ES)
Inventor: BELLER JOHANN
IPC: F04B49/06
Filed: 2000-06-28
Granted: 2006-11-16
Abstract: A pressure sensor (21') measuring the static pressure in the fluid pumped, produces a signal (x21) representing movements of the pump displacer. An electronic unit (22) evaluates the sensor signal. An independent claim is included for the method of monitoring the unit, in which an operational status signal is derived from the fluctuating pressure signal.
Patent ES-2286968-T3 (ES)
Inventor: PANHOLZER HEINZ DR
IPC: F03B13/12
Filed: 2000-08-24
Granted: 2007-12-16
Abstract: The arrangement raises and lowers a unit containing. two directly adjacent and/or stacked, interconnected turbine-generator units (5) or modules containing. at least two turbine-generator units that can be raised and lowered between an underwater operating position and a higher position by a lifting device (4). A guide device has an essentially horizontal beam movable along essentially vertical guides and guide elements for a removable turbine-generator unit or module. An Independent claim is also included for a method of raising and lowering units for generating electrical energy from water power.
Patent ES-2275472-T3 (ES)
Inventor: RIGAMONTI ENZO
IPC: H02B1/01
Filed: 2000-05-16
Granted: 2007-06-16
Abstract: A framework for metal cabinets and particularly for containing electrical equipment comprises closed box section elements (11) connected by connecting joints (12) having engagement projections (13) in the respective section member ends. The section members have a cross section with two arms (14) arranged at right angles to each other and a central part (15) for connection between the two arms which is inclined with respect to the arms and has opposing virtually parallel walls (15a,15b). The joint projections (13) have a cross section virtually complementary to the internal cross section of the section member to be accommodated therein with minimal play. The projection and the section member have holes (18,19,20) aligned with an axis perpendicular to the opposed walls of the section member for passage of a mutually locking screw (21) with the locking screw passing through a wall to screw into a threaded member (22) constrained to the opposite wall to grip the engagement projection between said two walls. <IMAGE>
Patent ES-2199783-T3 (ES)
Title: Compuestos de meetaloceno y su uso para polimerizacion de olefinas.
Inventor: OH JAE-SEUNG
IPC: C08F4/642
Filed: 2000-03-03
Granted: 2004-03-01
Abstract: Un compuesto de metaloceno que comprende uno o más compuestos representados por las siguientes Fórmulas Químicas 1 ó 2, en que al menos uno de los radicales hidrógeno de R2, R3 o B está sustituido por un radical seleccionado del grupo representado por la Fórmula Química 3: Fórmula Química 1: (C5R2l)pBs(C5R2m)MQ3-p Fórmula Química 2: **(Fórmula)** (en la que M es un metal de transición del Grupo 4; (C5R2l), (C5R2m) y (C5R2n) son un ligando ciclopentadienilo, un ligando ciclopentadienilo sustituido, un ligando ciclopentadienilo sustituido en que dos átomos de carbono adyacentes de un C5 se unen juntos para formar uno o más anillos C4-C16 por un radical hidrocarbilo, en que cada R2, que puede ser el mismo que o diferente de otro R2, es un radical hidrógeno, o un radical alquilo, cicloalquilo, arilo, alquenilo, alquilarilo, arilalquilo o arilalquenilo que tiene de 1 a 40 átomos de carbono, o un metaloide del Grupo 14 sustituido con radical hidrocarbilo; B es una cadena carbonada de alquileno, cadena carbonada de arileno, cadena carbonada de alquenileno, radical dialquilgermanio, dialquilsilicio, alquilfosfina o alquilamina sustituyendo sobre y formando puente con dos ligandos ciclopentadienilo o un ligando ciclopentadienilo y ligandos JR3z-y por un enlace covalente; R3 es un radical hidrógeno, o un radical alquilo, alquenilo, arilo, alquilarilo o arilalquilo que tiene de 1 a 40 átomos de carbono; J es un elemento del Grupo 15 ó 16; cada Q, que puede ser el mismo que o diferente de otro Q, es un radical halógeno, un radical alquilo, alquenilo, arilo, alquilarilo o arilalquilo que tiene de 1 a 20 átomos de carbono, o un radical alquilideno que tiene de 1 a 20 átomos de carbono; L es una base de Lewis; s es 0 ó 1, p es 0, 1 ó 2; (siempre que p sea 0 entonces s es 0; cuando s es 1 entonces l y m son 4; y cuando s es 0 entonces l y m son 5), y z es un número de valencia de J; con la condición de que si J es un átomo del Grupo 15, entonces z es 3; y cuando J es un átomo del Grupo 16, entonces z es 2; x es 0 ó 1; siempre que x sea 0, entonces n es 5, y es 1, y w es mayor que 0; cuando x es 1, entonces n es 4, y es 2, y w es 0.
Patent ES-2562208-T3 (ES)
Title: Tratamiento de enfermedad autoinmune
Inventor: FAUSTMAN DENISE
IPC: A61K35/74
Filed: 2000-03-10
Granted: 2016-03-03
Abstract: Bacilo Calmette-Guérin (BCG) para uso en el tratamiento de una enfermedad autoinmune probada en un ser humano, en el que la enfermedad autoinmune se selecciona de diabetes mellitus insulinodependiente, esclerosis múltiple, insuficiencia ovárica prematura, esclerodermia, enfermedad de Sjögren, lupus, vitíligo, alopecia, insuficiencia poliglandular, enfermedad de Grave, hipotiroidismo, polimiositis, pénfigo, enfermedad de Crohn, colitis, hepatitis autoinmune, hipopituitarismo, miocarditis, enfermedad de Addison, una enfermedad autoinmune de la piel, uveítis, anemia perniciosa, hipoparatiroidismo, y artritis reumatoide, caracterizado por que dicho uso comprende además: i) monitorizar periódicamente la tasa de muerte celular de células autoinmunes en dicho ser humano; y ii) ajustar periódicamente la dosis de BCG administrada a dicho ser humano basado en la monitorización de la etapa i), en el que dicho uso da como resultado un aumento del número de células funcionales de un tipo predeterminado en dicho ser humano.