Patent SG-11201908743S-A (SG)
Title: Methods and compositions for modulation of immune cells
Inventor: KEVLAHAN SEAN
IPC: G01N33/574
Filed: 2018-03-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIPO I PCT 1111111111110110101011111011010 I 010 11E11M 1110 (10) International Publication Number WO 2018/175408 A8 (51) International Patent Classification: C07K 16/28 (2006.01) GO1N 33/574 (2006.01) (21) International Application Number: PCT/US2018/023318 (22) International Filing Date: 20 March 2018 (20.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/473,730 20 March 2017 (20.03.2017) US (71) Applicant: QT HOLDINGS CORP [US/US]; 3F Gill Street, Woburn, MA 01801 (US). (72) Inventors: KEVLAHAN, Sean, H.; 8 Porter Road, North Reading, MA 01864 (US). BALL, Andrew; 6 Londonder- ry Lane, Georgetown, MA 01833 (US). QIN, Guokui; 379 Broadway, Apt. 57, Somerville, MA 02145 (US). WELLS, Steven, B.; 15 Glenville Ave #6, Allston, MA 02134 (US). JESURAJ, Nithya, Jothi; 166 Place Lane, Unit 166, Woburn, MA 01801 (US). COLE, Julie, M.; 223 Albion Street Apt 3, Wakefield, MA 01880 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (48) Date of publication of this corrected version: 17 January 2019 (17.01.2019) (15) Information about Correction: see Notice of 17 January 2019 (17.01.2019) GC GC O 71' N 00 O N C (74) Agent: MCDONALD, J., Cooper; Clark & Elbing LLP, 101 Federal Street, 15th Floor, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: METHODS AND COMPOSITIONS FOR MODULATION OF IMMUNE CELLS (57) : The invention features a hydrogel complex that can bind to and modulate a desired immune cell, e.g., T cell, population. In certain embodiments, the complex can be dissolved, and thus dissociated from its targeted cell, representing a safe and efficient approach for processing immune cells, e.g., T cells for clinical use. The invention also provides methods and apparatus for synthesizing hydrogel complexes, as well as methods of using the complexes to generate expanded immune cell, e.g., T cell, populations as part of adoptive immune cell, e.g., T cell, therapy systems.