Patent SG-11201810678W-A (SG)
Title: Glucocorticoid receptor agonist and immunoconjugates thereof
Inventor: MCPHERSON MICHAEL J
IPC: C07K16/24
Filed: 2017-06-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 11 1E10111111111111111111111112 11111111111111H1101111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/210471 Al 07 December 2017 (07.12.2017) WIP0 I PCT (51) International Patent Classification: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, C07J 71/00 (2006.01) A61K 31/58 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, C07K 16/24 (2006.01) A61P 37/00 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, A61K 47/68 (2017.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (21) International Application Number: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, PCT/US2017/035518 KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: Published: 01 June 2017 (01.06.2017) — with international search report (Art. 21(3)) — (25) Filing Language: English before the expiration of the time limit for amending the claims and to be republished in the event of receipt of (26) Publication Language: English amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (30) Priority Data: 62/344,948 02 June 2016 (02.06.2016) US 62/371,134 04 August 2016 (04.08.2016) US (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan Road, North Chicago, Illinois 60064 (US). (72) Inventors: MCPHERSON, Michael J.; 287 Pillsbury Road, Ashby, Massachusetts 01431 (US). HOBSON, Adri- an D.; 25 Holman Street, Shrewsbury, Massachusetts 01545 (US). HAYES, Martin E.; 3 Celestial Way, Pepperell, Massachusetts 01463 (US). MARVIN, Christopher C.; 242 Braxton Way, Grayslake, Illinois 60030 (US). SCH- MIDT, Diana; 40606 South Sunset Drive, Antioch, Illi- nois 60002 (US). WAEGELL, Wendy; 7 Rice Corner Road, Brookfield, Massachusetts 01506 (US). GOESS, Christian; 112 Mashapaug Road, Sturbridge, Massachu- setts 01566 (US). OH, Jason Z.; 5 Snowbell Lane, Worces- ter, Massachusetts 01606 (US). HERNANDEZ JR., Ax- el; 14 Laurie Lane, Charlton, Massachusetts 01507 (US). RANDOLPH, John T.; 304 Broadway Avenue, Liber- tyville, Illinois 60048 (US). Agent: STEFFE, Eric K. et al.; STERNE, KESSLER, GOLDSTEIN & FOX P.L.L.C, 1100 New York Avenue, NW, Washington, District of Columbia 20005 (US). (74) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) 1-1 1-1 N (84) Designated States (unless otherwise indicated, for every il• kind of regional protection available): ARIPO (BW, GH, 0 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 1-1 ei IN 1-1 (54) Title: GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF 0 ei (57) : Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods 0 of using the same, e.g., to treat autoimmune or inflammatory diseases.