Patent SG-11201407387U-A (SG)
Title: Use of ghrelin receptor inverse agonists or antagonists for treating sleep disorders
Inventor: DENNEY WILLIAM S
IPC: A61K45/06
Filed: 2013-05-21
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/182933 A1 (51) International Patent Classification: A61K 45/06 (2006.01) A61K31/506 (2006.01) A61K 31/397 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/054177 21 May 2013 (21.05.2013) English (30) Priority Data: 61/655,177 61/812,416 4 June 2012 (04.06.2012) 16 April 2013 (16.04.2013) English US US (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, New York, New York 10017 (US). (72) Inventors: DENNEY, William S.; 51 Holyoke Road #2, Somerville, Massachusetts 02144 (US). JACKSON, Mar­ garet; 56 Clyde Street, Somerville, Massachusetts 02145 (US). SONNENBERG, Gabriele; 189 Upland Road, Cambridge, Massachusetts 02140 (US). (74) Agent: KLEIMAN, Gabriel L.; 235 East 42nd Street, New York, NY 10017 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: USE OF GHRELIN RECEPTOR INVERSE AGONISTS OR ANTAGONISTS FOR TREATING SLEEP DISORDERS m 0\ CJ 00 FIG. 1 Example 1 2500- E a> (/> c D O o 76 C o N C CO a> E 2000- 1500- r-L, 1000- I I horizontal activity vertical activity 500- -800 I T 1 10 50 JL 150 1000 3 CD 0) 3 < CD I-600 £ tu o o c 3 -400 -200 0 CO CD 3 Example 1 mg/kg (57) Abstract: The present invention relates to methods of treating sleep dis­ orders in patients comprising administra­ tion of a ghrelin receptor inverse agonist or antagonist. The invention also includes methods of treating sleep disorders com­ prising the administration of a pharma­ ceutical composition comprising ghrelin a receptor inverse agonist or antagonist and at least one pharmaceutically acceptable carrier, diluent, or excipient. WO 2013/182933 A11 lllll llllllll II llllll III lllll lllll lllll III III III lllll lllll lllll lllll llll lllllll llll llll llll Declarations under Rule 4.17: — as to the identity of the inventor (Rule 4.17(i)) — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) — of inventorship (Rule 4.17 (iv)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))