baber/WOPTO huggingface dataset:
Patent CA-2266233-A1 (CA)
Title: A novel n-formylpeptide analogue: a potential inflammation and infection imaging agent
Inventor: RIBIC CHRISTINE MARIA
IPC: A61K51/08
Filed: 1999-03-19
Abstract: 1. Several hundred Rhenium (Re)-peptide libraries produced by combinatorial chemistry were screened to identify a potential high-affinity Tc-99m formyl-peptide receptor (FPR) antagonist or partial agonist radiopharmaceutical ideal for efficiently imaging sites of inflammation and infection. 2. Functional assays with various N-terminal capping group modifications identified several novel peptides which significantly stimulated or inhibited the release of myeloperoxidase (MPO) from elicited rat neutrophils ~ formyl-methionyl-leucyl-phenylalanine (fMLF) (p < 0.05).  3. Corresponding Re-complexed libraries exhibited varied binding affinity to the FPR receptor with several libraries exhibiting significant displacement of the 3H-fMLF. 4. In particular, competition binding of library ReORP553-17 significantly inhibited 3H-fMLF binding in a dose-dependent manner by 47.6 % and 91.4% when administered at lµM and 10 µM respectively. 5. Deconvolution compounds from Re-library RP553 17 exhibited IC50 values ranging from 0.73 (0.60 to 0.88) µM to 5.93 (2.96 to 11.91) µM in elicited rat neutrophils (r ~ 0.98). Deconvolution compound ReORP553 17-01 exhibited the greatest affinity binding to elicited rat neutrophils with a IC50 value of 0.73 (0.60 to 0.88) µM which was approximately 12-fold heater in affinity than known antagonist N-t-BocMLF in the present study (n=3; r =  0.99). 6. Competition binding of ReORP553 17-01 to human neutrophils indicated an IC50 value of 0.14 (0.008 to 2.4) µM (n=1; r =0.97) which was comparable to the IC50 value of 0.175 (0.03 to 1.04)µM for N-t-BocMLF. 7. MPO release was significantly reduced by 10µM ReORP553 17-01 (n=1) in cells stimulated with fMLF and release was not increased in PMNs lacking fMLF stimulation at this concentration (p < 0.05). Further studies indicate that ReORP553 17-01 antagonizes the release of intracellular Ca2+ in fMLF-stimulated neutrophils but causes increases in cells lacking fMLF  stimulation at concentrations between 1.0µM to 10µM. This indicates partial agonist function. 8. HPLC analysis of the radiolabelling of RP553 17-01 with Na[99Tc04]  indicated that the product 99mTc-RP553 17-01 had a radiochemical purity >90%. 9. This Re-based combinatorial approach identified several compounds that have potential as new Tc-99m-labelled FPR ligands which can be used for rapid identification of sites of inflammation or infection. In particular, the inhibitory function of ReORP553 17-01 on MPO release and rises in intracellular Ca2+ indicate that it may serve as an effective diagnostic agent without causing host tissue damage.
Patent CA-2267541-A1 (CA)
Title: Computer system and method of modifying program in the computer system
Inventor: OGATA HITOSHI
IPC: G06F9/445
Filed: 1999-03-30
Abstract: A computer system comprises a microcomputer and external memory means in communication with the microcomputer for storing various programs and various items of data. The microcomputer comprises a nonerasable ROM having stored therein a basic program and basic data indispensable to the operation of the system, a RAM for storing various programs or various kinds of data, a CPU for executing programs and processing data, and an interface circuit for providing communications with external devices.      The external memory means has stored therein a modification program for modifying a portion of program data contained in the basic program, and a modification starting address indicating a location in the basic program where the modification of the basic program by the modification program is to be started. The CPU has an address interrupt function for processing an interrupt at a predetermined interrupt address. The microcomputer modifies the basic program by transferring the modification program from the external memory means to the RAM, storing the modification starting address in the CPU as the interrupt address, and executing a command to dump to a head address of the modification program in the RAM for an address interrupt.
Patent CA-2268285-A1 (CA)
Title: Composition for making thermoplastic polyurethanes
Inventor: MASSE MICHAEL ALAN
IPC: C08G18/10
Filed: 1997-10-15
Abstract: This invention provides a composition for making thermoplastic polyurethanes, comprising as initial components: (a) from 1 to 80 % by weight of a polydiene diol having from 1.6 to 2 terminal hydroxyl groups per molecule and a number average molecular weight in the range from 500 to 20,000; (b) from 20 to 99 % by weight of a hard segment providing combination comprising an isocyanate having two isocyanate groups per molecule and, as a chain extender, a dimer diol; a process for preparing a thermoplastic polyurethane composition and thermoplastic polyurethane composition resulting therefrom.
Patent CA-2270409-A1 (CA)
Title: Novel mutations relating to x-linked charcot-marie-tooth disease
Inventor: SELTZER WILLIAM K
IPC: C12Q1/6883
Filed: 1999-05-12
Abstract: Specific mutations in the connexin-32 gene that are associated with X-linked Charcot-Marie-Tooth (CMT) disease are disclosed. Methods of diagnosing X-linked CMT disease are also disclosed. Methods include hybridization analysis, such as Southern or Northern analysis, which use hybridization of mutant connexin-32 nucleic acid probes to connexin-32 genes; direct mutation analysis by restriction digest; sequencing of the connexin-32 gene; hybridization of an allele-specific oligonucleotide with genomic DNA; or identification of mutant connexin-32 proteins. Mutant connexin-32 nucleic acid probes are also disclosed. The mutant connexin-32 nucleic acid probes have a mutation in at least one of the following codons: 13, 16, 20, 28, 29, 41, 75, 79, 80, 85, 86, 94, 106, 124, 131, 158, 161, 169, 178, 180, 189, 191, 193, 219, 220, 230, and 267. Mutant connexin-32 nucleic acid probes having more than one of the mutations described above are also described, as are mutant connexin-32 nucleic acid probes having other mutations in addition to at least one mutation as described above. Isolated, mutant connexin-32 proteins encoded by mutant connexin-32 genes, as well as antibodies specific for the mutant connexin-32 proteins, are also disclosed.
Patent CA-2270868-A1 (CA)
Inventor: FRANK GLENN ROBERT
IPC: G01N33/68
Filed: 1997-11-24
Abstract: The present invention includes a method to detect IgE using a human Fc epsilon receptor (Fc~R) to detect IgE antibodies in a biological sample from a cat, a dog, or a horse. The present invention also relates to kits to perform such methods.
Patent CA-2271214-A1 (CA)
Inventor: COVERT MARK S
IPC: G06Q20/00
Filed: 1999-05-07
Abstract: 99 An automated banking machine (12) is operative to conduct transactions in response to HTML documents and TCP/IP messages exchanged with a local computer system (14) through an intranet (16), as well as in response to messages exchanged with foreign servers (20, 22, 24, 26, 28, 96) in a wide area network (18). The banking machine includes a computer (34) having an HTML document handling portion (76, 80, 82). The HTML document handling portion is operative to communicate through a proxy server (88), with a home HTTP server (90) in the intranet or the foreign servers in the wide area network. The computer further includes a device application portion (84) which interfaces with the HTML document handling portion and dispatches messages to operate devices (36) in the automated banking machine. The devices include a sheet dispenser mechanism (42) which dispenses currency as well as other transaction devices. The device application portion communicates with a device interfacing software portion (64) in the banking machine through a device server (92) in the intranet. The device server maintains local control over the devices in the banking machine including the sheet dispenser. The banking machine operates to read indicia on the user's card corresponding to a system address. The computer is operative to connect the banking machine to the home or foreign server corresponding to the system address, which connected server operates the banking machine until the completion of transactions by the user.
Patent CA-2273871-A1 (CA)
Title: Lamp apparatus with reflective ceramic sleeve holding a plasma that emits light
Inventor: WALKER DALE S
IPC: H01J61/33
Filed: 1997-12-16
Abstract: A lamp apparatus (10A) for producing a beam of light that can be used as a part of a source for a projection system. The lamp apparatus (10A) of the present invention produces a beam of light (26) originating from a small aperture (15). The apparatus includes an electrodeless lamp body in the form of elongated outer tube (11) having a hollow interior. An inner sleeve (12) fits or is deposited inside the outer tube (11), the inner sleeve (12) having a fill (23) containing generally cylindrically or spherical shaped bore. The sleeve provides temperature resistant and reflection properties. Electrodes (24 and 25) positioned either internally or externally of the lamp body (11) are provided for producing radio frequency energy that excite the fill (23) contained in the bore of the inner sleeve (12) to form a plasma light source of intense heat. The light thus generated by the plasma in a relatively large volume is constrained to exit through a small aperture at either one, or both, ends of the apparatus (10A).
Patent CA-2275777-A1 (CA)
Inventor: LEVINE LOUISE RICHMAN
IPC: C07D307/93
Filed: 1998-01-23
Abstract: Agonistes agissant au niveau des récepteurs de glutamate métabotropique à liaison adénosine-monophosphate cyclique et à couplage négatif, utilisés pour traiter des troubles dysphoriques prémenstruels.
Patent CA-2277083-A1 (CA)
Title: Preparation of olefinic compounds and carboxylic derivatives thereof
Inventor: WU TSE-CHONG
IPC: C07C51/14
Filed: 1998-01-08
Abstract: Arylolefinic compounds are prepared by reacting aryl halide with an olefinic compound in the presence of a polar liquid reaction medium containing (a) secondary or tertiary amine as a hydrogen halide acceptor, (b) a catalyst system formed from (i) Pd or Pd(0) compound, and/or Pd(I) salt or Pd(II) salt, and (ii) a tertiary phosphine ligand, and (c) a reaction accelerating amount of water in the range of 0.5 to 5 weight percent of the total weight of the reaction mixture. The arylolefinic compounds can be converted to an arylcarboxylic acid by hydrocarboxylation with CO in a reaction medium freed of amine and containing water and a Pd catalyst system as above in which a copper component may be included, and which preferably includes an ether such as THF.
Patent CA-2279654-A1 (CA)
Title: High resistance grounding systems for oil well electrical systems
Inventor: SHIPP DAVID D
IPC: E21B47/12
Filed: 1999-08-06
Abstract: In accordance with the invention, a normally ungrounded power system for a oil well is provided which includes power transformer above ground and a pump motor below ground. There is provided a signal system which includes a below ground sensor system and an above ground signal conditioning and monitoring unit where the sensor system utilizes the main power lines for carrying the sensor signals. A connectable high resistance grounding scheme is provided to the aforementioned floating system, so that in the event of a arcing ground fault or similar occurrence the system may be immediately grounded, thus compensating for the effects of the arcing ground fault and providing personnel safety and electrical equipment protection. When the high resistance grounding system is not utilized the aforementioned signals from the sensors are easily carried by the power conductors.
Patent CA-2281265-A1 (CA)
Title: Method for manufacturing a nonlinear optical thin film
Inventor: NAKAMURA NAOKI
IPC: G02F1/355
Filed: 1999-08-31
Abstract: A method for manufacturing a nonlinear optical thin film of a silica glass system with sufficient nonlinear optical characteristics, in which a glass substrate 12 is disposed within a vacuum deposition chamber 10 and an electron beam is applied to a SiO2-GeO2-system glass placed on a hearth liner 14 to form a SiO2-GeO2-system thin film on the surface of the substrate 12. In an application of this method, ions of argon, for example, are emitted from an ion source to produce dipoles in the deposited SiO2-GeO2-system thin film. By applying an electric field to the SiO2-GeO2-system thin film thus formed, the dipoles are oriented to let the thin film exhibit nonlinear optical characteristics.
Patent CA-2281975-A1 (CA)
Inventor: MCFALL RONALD RAY
IPC: A61F13/15
Filed: 1995-04-03
Abstract: A sanitary napkin is disclosed having an absorbent core comprising a central core segment and two side core segments. The sanitary napkin also includes a lifting member for displacing the central core segment relative to the side core segments.
Patent CA-2282169-A1 (CA)
Title: Automatic call distribution system using isdn pri two b-channel transfer
Inventor: SETHIA KAMAL S
IPC: H04Q11/04
Filed: 1999-09-14
Abstract: An automatic call distribution (ACD) system connected to a switch in a telephone network over an ISDN      PRI interface. The ACD system receives a customer call and determines which agent should handle the call. The ACD system places an outgoing call to the agent. When the agent answers, the ACD system exchanges ISDN PRI      Two B-Channel Transfer (TBCT) messages with the switch to cause the incoming customer and outgoing agent calls to be directly connected. When the incoming and outgoing calls are directly connected, the ACD is disconnected from both calls. The ACD is notified when the call between the agent and the customer is cleared.
Patent CA-2283536-A1 (CA)
Title: Compositions and methods for elimination of unwanted cells
Inventor: CATTANEO ROBERTO
IPC: C12N5/08
Filed: 1998-03-10
Abstract: Disclosed is a recombinant nucleic acid vector for use in gene therapy of malignant disease, the vector directing the expression on a eukaryotic cell surface of a syncytium-inducing polypeptide.
Patent CA-2284815-A1 (CA)
Title: Device for stabilising the two lower steering arms of a tractor
Inventor: ADAMEK WOLFGANG
IPC: A01B63/10
Filed: 1999-10-05
Abstract: The invention relates to a device for stabilising the two lower steering arms 1 of a tractor. The lower steering arms 1 can be actuated by a hydraulically operated power lever 9 and are each associated with a side strut 6 with a first single-acting hydraulic cylinder 7 for stabilising and fixing purposes. A line connection between the first single-acting hydraulic cylinders 7 and the power lever 9 can be effected by a control valve 13.      To centre the lower steering arms 1 and set same to a predetermined dimension of spread, even when no implement is attached, the line 14 leading to the second single-acting hydraulic cylinder 10 for the power lever 9 contains a pressure-controlled first return valve for which there is provided a bypass line 21 with a second return valve 22 locking in the direction opposite to that of the first return valve.
Patent CA-2284884-A1 (CA)
Title: Systeme de visioconference
Inventor: MAHIEUX YANNICK
IPC: H04M11/00
Filed: 1998-03-26
Abstract: L'invention concerne un système de visioconférence entre participants localisés sur des sites distants, comprenant sur chaque site un écran de visualisation. Selon l'invention, l'écran de visualisation est un grand écran (10) du type écran de projection ou de rétroprojection ou de type à vision directe, formé par un ou plusieurs systèmes de visualisation formant un mur d'images pour visualiser simultanément tous les participants distants dans un espace reconstitué sur le mur d'images que forme cet écran (10), et le système comprend pour chaque site donné des moyens de répartition spatiale du son (100A, 100K, Hi, Mj) pour établir une correspondance entre le son généré par chaque participant distant et son image visualisée sur l'écran du site considéré.
Patent CA-2285574-A1 (CA)
Title: Method and composition for treating sleep apnea
Inventor: MEYER KEITH C
IPC: A61K35/42
Filed: 1998-04-16
Abstract: Application of synthetic or naturally occurring lung surfactant to the posterior pharyngeal region prior to a period of sleep significantly reduces episodes of sleep disturbance resulting in apnea or hypopnea. The present invention provides lung surfactant in a convenient applicator container for easy use and storage. Incidents of oxygen desaturation are reduced, thereby lowering the risks of apnea-associated pathologies.
Patent CA-2285781-A1 (CA)
Inventor: HICKOX MATTHEW S
IPC: A46B15/00
Filed: 1999-10-08
Abstract: The invention, in it's simplest form, is a toothbrush system with a motion sensor that detects and measures the time period when a threshold level of brushing motion is occurring. The system stops measuring the brushing time period when the brushing motion falls below the threshold motion level. A timer accumulates the periods of brushing and an indicator mechanism notifies the user when the brushing period reaches a predetermined brushing time interval. The indicator results are stored for a certain time period allowing the indicator to be monitored. The device is readily adaptable to fit over existing toothbrushes via an elastomeric sleeve or be incorporated into a new toothbrush.
Patent CA-2286407-A1 (CA)
Title: Liquid fuel burner, notably for iron and steel product reheating furnaces
Inventor: PAHMER FRANCOIS
IPC: F27D99/00
Filed: 1999-10-07
Abstract: The burner, producing an axially-symmetrical flame with axial development, has a broad combustion tunnel (10) with oxidant and fuel injection orifices (13, 14) lying parallel to its longer axis of symmetry. The tunnel can be rectangular or oval in shape, or a combination of these, with the axes of the injection orifices lying in planes parallel to the plane of the products to be treated.
Patent CA-2287097-A1 (CA)
Title: Procede et instrument de controle de la liaison de l'ame alveolee d'un nid d'abeilles sur une peau
Inventor: WEISS GERARD
IPC: G01B11/30
Filed: 1999-10-21
Abstract: L'invention propose un procédé de contrôle de la liaison de l'âme alvéolée d'un nid d'abeilles (1) sur une peau (2), ledit procédé comportant les opérations suivantes: - éclairer par une source lumineuse (15) une zone dite éclairée (17) sur la surface libre (4) du nid d'abeilles (1), afin d'illuminer l'intérieur des alvéoles (5) débouchant dans ladite zone éclairée (17), - détecter la lumière émergente (21) ressortant des alvéoles (5) dans une zone dite observée (22), la distance minimale entre ladite zone éclairée (17) et ladite zone observée (22) étant notée E et définissant une direction D. Un tel procédé est remarquable en ce que la distance E est au moins égale à la largeur L1 des embouchures (6), ladite largeur L1 étant prise selon la direction D, afin de rendre impossible la présence simultanée de la zone éclairée (17) et de la zone observée (22) au-dessus de l'embouchure (6) d'une même alvéole (5). L'invention propose aussi un instrument spécialement conçu pour mettre en oeuvre le présent procédé.
Patent CA-2290006-A1 (CA)
Title: Method of processing cyanide ions by ozone
Inventor: KIKUTA NAOKO
IPC: C02F1/78
Filed: 1999-11-17
Abstract: A method is provided for decomposing free cyanide ion and metallic cyano complex ions in a liquid, comprising the steps of bringing the liquid into contact with ozone gas in a counterflow relation in the condition that the pH of the liquid is at least with the mass flow rate of the ozone in the ozone gas up to 20 mg per minute per liter of liquid, and then bringing the liquid into contact in a counterflow relation with ozone gas having an ozone concentration of at least 150 g/Nm3 in the condition that the pH of the liquid is 7.0 to 9.5.
Patent CA-2291140-A1 (CA)
Inventor: MAEDA KAZUHIRO
IPC: C23C22/56
Filed: 1998-05-21
Abstract: A chromium-free water-based surface treatment liquid which contains from 0.01 to 50 g/l of a total of dissolved manganic acid, permanganic acid, and salt(s) thereof and from 0.01 to 20 g/l of a total of dissolved titanium compounds and has a pH of from 1.0 to 6.0 reacts rapidly with aluminum and aluminum alloy surfaces to deposit thereon a protective coating that does not contain hexavalent chromium and has excellent corrosion resistance and paint film holding properties.
Patent CA-2291561-A1 (CA)
Title: Work transfer lock system and method
Inventor: BARTHALOW HENRY DAVID
IPC: B66C13/54
Filed: 1999-12-03
Abstract: A work transfer lock system and method includes a first work device, a second work device, a first platform, and a second platform. The system includes a locking device which locks the first platform relative to the second platform. The locking device further includes work transferring mechanisms which transfer work from the first work device to the second work device when the first platform is locked relative to the second platform.
Patent CA-2292216-A1 (CA)
Inventor: BRUNER RODNEY WILLIAM
IPC: H02B1/21
Filed: 1999-12-14
Abstract: Heat sinks extending rearward from and connected to the risers of a switchgear assembly by the same fasteners which secure the stabs to the risers dissipate the joule heat generated by current flow through the risers and stabs and accommodate for the higher temperature rise permitted in the power circuit breakers engaged by the stabs. The heat sinks are formed by a pair of heat sink members straddling the risers, each of which has an elongated flat body with an extended flat mounting surface on a first face which provides extended surface engagement with a stab. The elongated body projects rearward beyond the stab and a first set of transverse fins project from the first face rearward of the stab toward the first set of fins on the other heat sink member of the pair. A second or additional set of fins project laterally outward from a second face opposite the first face of the elongated body and are dimensioned to maintain appropriate through-air clearance with the additional fins on the heat sinks on an adjacent riser.
Patent CA-2294025-A1 (CA)
Inventor: KOYAMA YOSHIHISA
IPC: B67B7/42
Filed: 1998-06-17
Abstract: A fitting clamping device for pressure vessels, in which a fitting mounted on a mouthpiece (3) on a pressure vessel (2) such as a beer barrel is clampled, comprising a clamping torque generating device (25). Wherein swing bases (58, 59) are fixedly mounted on a base (32) which can be vertically moved toward and away from the pressure vessel (2) by a lift driving source (31) supported by a lift frame (23) so as to be capable of swinging back and forth and right and left, and a rotation drive source (33) is loaded on the swing base (58), while a clamp output shaft (54) of the rotation drive source (33) is extended downward to detachably couple thereto a clamping head (30) so that a skirt portion (73) having a tapered surface (74) brings thereinto the mouthpiece (3) to permit a wrench portion (72) thereof to engage with a ratchet of the fitting mounted on the mouthpiece (3). Accordingly, even when the axis of the clamping head is not aligned with the axis of the mouthpiece on a beer barrel, the clamping head accommodates inclination therebetween to thereby enable clamping of the fitting.
Patent CA-2294096-A1 (CA)
Title: Synthetic turf game surface
Inventor: LEMIEUX ALAIN
IPC: E01C13/08
Filed: 1998-06-09
Abstract: A synthetic turf surface for golf courses, tennis courts and other grass-surfaced game playing fields is formed of a synthetic grass carpet having a flexible base sheet (14) with closely spaced-apart upright, blade-like strands (12) of plastic material forming a dense grass-like surface. The carpet is supported upon a cushioning underpad (18) which is formed of a thick, molded sheet of open cell, expanded bead polypropylene.      The resiliently compressible polypropylene underpad combined with the synthetic grass carpet closely simulates the feel of a natural grass covered playing surface.