Patent SG-11201811290V-A (SG)
Title: Compositions and methods for the depletion of cd117+cells
Inventor: NIXON ANDREW
IPC: C07K16/28
Filed: 2017-06-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -,` 1#1101111 0 Hill 11111 010 1111 1 001l 01111110110101111101111101111001111 Organization International Bureau (10) International Publication Number (43) International Publication Date .......'\" WO 2017/219029 A3 21 December 2017 (21.12.2017) W I PO I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: Adam; 84 Harvard Ave., Apt. 2, Brookline, MA 02446 C07K 4/04 (2006.01) Cl 2N 5/00 (2006.01) (US). CO7K 16/28 (2006.01) (74) Agent: COWLES, Cristin, H.; Womble Bond Dickinson International Application Number: (US) LLP, P.O.Box 7037, Atlanta, Georgia 30357 (US). PCT/US2017/038158 (81) Designated States (unless otherwise indicated, for every International Filing Date: kind of national protection available): AE, AG, AL, AM, 19 June 2017 (19.06.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, Publication Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, Priority Data: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 62/351,725 17 June 2016 (17.06.2016) US MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 62/437,729 22 December 2016 (22.12.2016) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/448,782 20 January 2017 (20.01.2017) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Applicant: MAGENTA THERAPEUTICS, INC. (84) Designated States (unless otherwise indicated, for every [US/US]; 50 Hampshire Street, 8th Floor, Cambridge, MD kind of regional protection available): ARIPO (BW, GH, 02139 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Inventors: NIXON, Andrew; 41 Evergreen Lane, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Hanover, MA 02339 (US). MORROW, Dwight; 1230 Wa- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, terford Road, West Chester, PA 19380 (US). HARTIGAN, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = — = Title: COMPOSITIONS AND FIG. 100- 4. > 75 c .— x 4) 50 c c < 4 8 25 tv LI .... 4.1 0.. : The invention provides hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. Described herein are antibodies, -binding fragments, ligands, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, depleting a population of CD1 17+ cells in a patient, such as a human. The compositions and methods described herein can be used treat a disorder directly, for instance, by depleting a population of CD1 17+ cancer cells or autoimmune cells. The compositions methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the of hematopoietic stem (57) N engraftment © procedure. METHODS FOR THE DEPLETION OF CD117+CELLS 1 Kasumi-1 Cell Viability M027-saporin . . ,, e- , isotype-saporin —A- CD117 Abl-saporin — (54) = = = = = = = _ = = = = = — = = -12 -11 -10 -9 -8 Concentration LOG(M) compositions and methods useful for the depletion of CD1 17+ cells and for the treatment of cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant _ M CN various ei C antigen 01 by Il to el ---- and Il N C [Continued on next page] WO 2017/219029 A3 IMEDIMO MO1 01011M0101110 010HOHMO 1101 °MOINE 00# MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 25 January 2018 (25.01.2018)