Patent CA-3090823-A1 (CA)
Inventor: FREEMAN JENNIFER L R
IPC: A61P3/10
Filed: 2019-05-01
Abstract: CA 03090823 2020-08-07 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111 1 11111111 111111 1 11 11111 1 111 11111 1 11 1 111 1 1111 111 1 111 1111 111 1111111111 1 111111 Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2019/217165 Al 14 November 2019 (14.11.2019) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/4741 (2006.01) A61P 3/04 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/538 (2006.01) A61P 9/12 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, A 61K 45/06 (2006.01) A61P 3/10 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, A61K 31/155 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ED, EL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (21) International Application Number: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, PCT/U52019/030110 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (22) International Filing Date: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 01 May 2019 (01.05.2019) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 62/668,384 08 May 2018 (08.05.2018) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant: VTV THERAPEUTICS LLC [US/US]; 4170 EE, ES, FL FR, GB, GR, HR, HU, EE, IS, IT, LT, LU, LV, Mendenhall Oaks Pkwy, High Point, North Carolina 27265 MC, 1VIK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (72) Inventors: FREEMAN, Jennifer L.R.; 154 Surtees Road, KM, ML, MR, NE, SN, TD, TG). Winston-Salem, North Carolina 2'7104 (US). VALCARCE LOPEZ, Maria Carmen; 1'785 Deer Run Ct., Oak Ridge, Published: North Carolina 2'7310 (US). ¨ with international search report (Art. 21(3)) = (74) Agent: ROLLINS, Samuel B.; 4170 Mendenliall Oaks Pkwy, High Point, North Carolina 27265 (US). (54) Title: THERAPEUTIC USES OF GLP1R AGONISTS (57) Abstract: Methods of using glucagon-like peptide 1 receptor (GLP1R) agonists are generally disclosed herein. In certain aspects, the disclosure pro-. vides methods of treating type 2 diabetes that include administering a GLP1R 2 agonist according to certain dosage regimens. In certain other aspects, the disclosure provides methods of treating obesity that include administering a g 1 GLP1R agonist according to certain dosage regimens. In certain other aspects, the disclosure provides methods of lowering glycated hemoglobin (for exam-= ple, lowering HbAlc) that include administering a GLP1R agonist according . 4.4 to certain dosage regimens. Compositions containing GLP1R agonists and their manufacture, for example, for use as a medicament are also disclosed herein. ..1. : E -2 :a 0. A. -a _3 -X 0 .0' 4 Dow 6119ficg) 11 FIGURE 1