baber/WOPTO huggingface dataset:
Patent KR-200492387-Y1 (KR)
IPC: A01G3/02
Filed: 2018-09-04
Granted: 2020-09-29
Abstract: 본 고안은 포도 알 솎기 기구에 관한 것으로, 힌지축을 기준으로 회전 가능하게 교차 결합되며, 각각의 후단에 손잡이부가 구비되는 한 쌍의 회전레버; 및 상기 회전레버들 각각의 전단에 연결된 제1 핑거 및 제2 핑거를 갖는 집게부를 포함하고, 상기 제1 핑거와 상기 제2 핑거는, 상호 마주보는 대응면을 갖고, 상기 회전레버들의 대응되는 회동에 연동하여 밀착 또는 이격되며, 상기 상호 마주보는 대응면들은 각각 오목한 파지홈을 구비하며, 상기 제1 핑거와 상기 제2 핑거는 상기 힌지축의 축 방향으로 편향되게 연장된다.
Patent KR-200489504-Y1 (KR)
IPC: F24C15/20
Filed: 2019-03-14
Granted: 2019-06-27
Abstract: 본 고안은 그릴 회전기능이 마련된 바베큐장치에 관한 것으로서, 보다 상세하게는 식재료를 불로 구울 수 있도록된 바베큐장치로써, 일정간격을 유지하며 배치되는 한쌍의 전방지주유닛과 한쌍의 후방지주유닛으로 이루어진 지주부와 지주부의 상부에 형성되는 고정틀로 이루어진 바베큐틀본체와, 상기 바베큐들본체에는 열기조절승강수단으로 이루어지며, 상기 열기조절승강수단은 상기 바베큐틀본체의 내부에 배치되어 승강되고 양측에 승강고정패널이 형성된 승강틀과, 상기 승강틀을 승강시키는 승강부로 구성되고, 상기 승강부는 상기 후방지주유닛을 연결하며 회전되게 형성되는 회전축과, 상기 전방지주유닛에 형성되는 안내관과, 상기 안내관에 관통되게 배치되는 볼스크류와, 상기 볼스크류의 단부에 체결되어 상기 볼스크류의 회전에 의해 인입 또는 인출되는 이송관으로 이루어진 구동부와, 상기 회전축의 단부에 일단이 고정되고 타단이 상기 이송관에 축결합되는 회동샤프트와, 상기 회전축에 일단이 고정되고 타단이 상기 승강고정패널에 축결합되는 전달패널로 이루어져, 바베큐그릴에 열기조절승강수단과 그릴회전수단이 마련되어 열기를 승강시켜 조리할 대상물의 가해지는 가열온도를 조절할 수 있어 효율적인 조리가 가능하게 되고, 조리되는 대상물을 뒤집어 가열할 수 있어 조리 대상물을 균일하게 익힐 수 있게 되는 효과가 있다.
Patent KR-200490856-Y1 (KR)
IPC: G01S11/12
Filed: 2019-04-30
Granted: 2020-03-02
Abstract: 본 고안은 핸드폰을 근접시키는 모션을 인지하여 핸드폰을 고정하는 홀더가 자동으로 벌어지고 좁혀져 핸드폰을 고정시킨 상태에서 무선 충전이 이루어지고 다시 충전기로부터 핸드폰을 분리할 수 있도록 한 모션 감지에 따른 자동 홀딩 기능을 갖는 무선충전기에 관한 것으로서, 그 구성은 프론트커버 및 리어커버로 분리 구성된 기기본체와; 상기 기기본체의 내부에 구비되어 외부의 수신코일과 전자기적으로 커플링되어 유도전류를 발생시켜 배터리를 충전시키는 발신코일과; 상기 기기본체의 내부, 및 프론트커버에 각각 구비되어 핸드폰을 기기본체에 근접시키는 모션을 인지하는 적외선 센서 및 적외선 센서렌즈와; 상기 기기본체의 양측에 구비되고, 동력을 전달받아 서로 대칭되는 좌.우 방향으로 벌어지고 좁혀지면서 휴대폰을 자동으로 프론트커버의 전면부에 고정하거나 해제하는 한 쌍의 고정홀더A 및 고정홀더B와; 상기 적외선 센서를 통해 인지된 동작제어 명령신호에 따라 상기 고정홀더A 및 고정홀더B를 서로 대칭되는 좌.우 방향으로 벌어지게 하거나 다시 좁혀지도록 구동시키는 홀더구동부;로 이루어진 것이다.
Patent KR-200496286-Y1 (KR)
IPC: B25B11/02
Filed: 2020-08-20
Granted: 2022-12-22
Abstract: 본 고안에 따른 길이 방향으로 관통된 내부 공간을 포함하고, 폭 방향으로 나란하게 체결되고, 소정 길이를 갖는 제1 탱크와 제1 탱크보다 길이가 긴 제2 탱크의 바닥면을 동일 평면 상에 배치시키는 수평 지그는, 제1 탱크를 수용하는 제1 몸체부 및 제2 탱크를 수용하는 제2 몸체부를 포함하고, 제1 몸체부는 제1 탱크를 소정 높이 상승시켜, 제1 탱크의 바닥면의 높이를 조절하는 높이 조절부를 포함하고, 상기 소정 높이는 상기 제1 탱크와 상기 제2 탱크의 길이 차이이고, 제1 및 제2 탱크의 바닥면은 하나의 평판형 커버 부재에 의해 커버될 수 있다.
Patent KR-200497015-Y1 (KR)
Title: 그립 롤러 장치 및 이를 포함하는 진공 스테이지 구조체
IPC: H01L21/687
Filed: 2021-06-07
Granted: 2023-07-05
Abstract: 가압 이동부; 및 상기 가압 이동부를 이동시키는 롤러 구동부를 포함하되, 상기 가압 이동부는: 제1 방향에 평행한 중심 축을 갖는 복수 개의 그립 롤러; 상기 제1 방향에 교차되는 제2 방향으로 연장되는 연결 부재; 및 상기 제1 방향 및 상기 제2 방향의 각각에 교차되는 제3 방향으로 연장되며 상기 복수 개의 그립 롤러의 각각을 상기 연결 부재에 연결시키는 복수 개의 지지 부재를 포함하고, 상기 복수 개의 그립 롤러의 각각은 밑으로 갈수록 직경이 좁아지는 축경부를 포함하는 그립 롤러 장치가 제공된다.
Patent PH-22014000114-Y1 (PH)
Title: An improved prefabricated poultry house with swing walls
Inventor: BATOMALAQUE ENGR JOSE REY S
IPC: A01K31/18
Filed: 2014-03-17
Abstract: This utility model relates to an innovative prefabricated poultry house with swing walls and comprised by a metal roof panel with apex metal ridge vent attached to a plurality of prefabricated galvanized metal trusses that are further attached and carried by a plurality of steel columns anchored to concrete pedestals, a plurality of prefabricated and adequately insulated fixed and swinging wall panel assemblies installed and interconnected in between steel columns and on concrete wall pedestals forming a rectangular enclosure, and an insulated flat metal ceiling panels, creating as a whole an insulated and airtight interior for said poultry house. A set of fans installed at one longitudinal end of said rectangular enclosure and a set of cooling pads at the opposite end at its opposing longitudinal sides are means for tunnel ventilation of the structure that will lead to a highly efficient chicken growing. In anticipation of prolonged power failure or incidents of similar nature, the swing walls are designed to be opened so that it can provide natural ventilation to an airtight-designed poultry house to eradicate or lessen death among chickens. The aforesaid prefabricated components are so designed that they are fitted and connected for faster construction. The manner of design, function and construction is an advancement of prior art in poultry house.
Patent PH-22017000649-Y1 (PH)
Title: Process of producing coconut-water-treated botted mackerel (scomber japonicus) in tomato sauce
Inventor: MACACHOR CORAZON P
IPC: A23L17/00
Filed: 2017-09-13
Abstract: This utility model disclosed the process of coconut water treated bottled mackerel Scomber japonicus in Tomato Sauce for human consumption wherein the method of preparing the bottled mackerel includes coconut water pre-treatment, packing of dressed mackerel into the glass jars, steaming, draining, adding of ingredients such as tomato sauce, tomato katsup, com oil, tomato paste, refined sugar, iodized salt and hot pepper, sealing the jars, exhausting, venting, processing for 90 minutes at 240oF, cooling and labelling.
Patent PH-22018000201-Y1 (PH)
Title: Firetruck with multi-motion boom
Inventor: GARCIA STEPHEN ANTHONY A
IPC: A62C27/00
Filed: 2018-03-13
Abstract: A firetruck is disclosed having a multi-motion boom at the back of passenger cabin. The multi-motion boom comprises a vertical frame configured to move or rotate in a circumferential manner, an elongated arm operably connected to the frame and configured to move angularly in an upward manner and extending upwardly in a telescopic manner. The boom further comprises a hydraulic actuator connected to the frame and configured to actuate the elongated arm angularly.
Patent PH-22018050193-Y1 (PH)
Title: Fragaria vesca L., Garcinia mangostana, and Nephelium lappaceum Chewable Tablet Composition
Inventor: TORRES ROSALINDA C
IPC: A61K36/77
Filed: 2018-05-18
Abstract: The present utility model relates in general to a chewable tablet composition. More specifically, the present utility model relates to a chewable tablet composition comprising extracts of the fruits Fragaria vesca L. (strawberry), Garcinia mangostana (mangosteen), and Nephelium lappaceum (rambutan). According to this utility model, the chewable tablet comprising strawberry, mangosteen and rambutan extracts exhibits anti-oxidant activity, disintegrates easily for increased absorption by the digestive tract, and is oval in shape for easier intake and faster esophageal transit time.
Patent PH-22019001021-Y1 (PH)
Title: Formulation of breadfruit tartlet
Inventor: ALBURO ROSALYN P
IPC: A23L19/00
Filed: 2019-08-05
Abstract: The present utility model discloses the formulation of producing breadfruit tartlet. Breadfruit ( Artocarpus altilis, Fosb.) of the family Moraceae is a seasonal tropical fruit tree that is an undervalued and under-utilized fruit in the Philippines. When in season, this tree produces plenty of fruits that are just wasted and left to rot. There is a need to explore on fruit utilization methods and other processing techniques to improve the value of this very prolific crop. Utilizing this commodity into another way of preparation and presentation is therefore a welcome development.
Patent PH-22020050708-Y1 (PH)
Title: Orange sweet potato powder rich in gamma-aminobutyric acid
Inventor: GARCIA ROSEMARIE G
IPC: A23L19/15
Filed: 2020-12-10
Abstract: The present utility model concerns a food powder. Particularly, the utility model pertains to a gamma-aminobutyric acid rich orange sweet potato powder, obtainable by the process comprising of the steps of slicing orange sweet potatoes; drying the sliced orange sweet potatoes in a forced draft dryer at a temperature of 60 to 80øC for 4 to 8 hours; and grinding the dried orange sweet potatoes to form a powder. The obtained powder has a gamma-aminobutyric acid content of 100 to 200 mg/100g of powder and can be used as a functional additive in food and beverage applications.
Patent BR-202015001216-Y1 (BR)
Title: presilha de fixação aplicada em grades de proteção de ventiladores
Inventor: PEDRO CELSO DAL MORO
IPC: F04D29/70
Filed: 2015-01-19
Abstract: É descrita uma presilha de fixação aplicada em grades de proteção de ventiladores que compreende uma base prismática injetada em plástico (10) que garante a pré-fixação das grades superior (100) e inferior (110) para o acoplamento mediante um pino girante (20) manipulado através de uma ferramenta, impedindo a retirada de forma facilitada e sem o uso de ferramental específico, atendendo as normas de segurança IEC 60335-2-80.
Patent GB-1328611-A (GB)
Title: Laminated structures
IPC: B32B7/027
Filed: 1972-01-03
Abstract: 1328611 Laminates ZITO CO Inc 3 Jan 1972 [2 Feb 1971] 172/72 Heading B5N [Also in Divisions B2 and H1] A process for forming a laminate from thermoplastic materials comprises the steps of spreading particles of a porous filler of irregular surface configuration 14 on to the surface of a first layer 10, subjecting at least the surface of the first layer to a temperature which softens the surface and applying pressure to partially embed the porous filler particles in the first layer so that they protrude from the surface, cooling the first layer under the applied pressure removing excess particles from the surface, placing the material from which a second layer 18 is to be formed on the surface of the first layer containing the embedded filler particles, subjecting the layers to a temperature below that used above to adhere the second layer to the first and cooling the laminate. The porous filler particles may be activated carbon. The first layer may comprise a polyfluorocarbon and may be a graphite loaded polyvinylidene fluoride. The second layer may comprise polyethylene and contain inert fillers such as activated carbon or diatomaceous earth.
Patent CR-5290-A (CR)
Title: Metodo para obtener un envase plastico moldeado
Inventor: KURT H RUPPMAN
IPC: B29C49/48
Filed: 1996-03-26
Abstract: Una preforma de tereftalato de polietileno que tiene un cuerpo cilindrico con una tapa, una boca roscada y un cuello provisto de un collar, es precalentado para ablandar el PET. La preforma es introducida en un molde partido cuyas paredes se calientan a una temperatura de entre 150 grado centigrados y 177grados centigrados. Un vastago estirador es introducido en la preforma para estirarla axilmente hasta que la preforma alcanza la longitud del producto final. Se expande y se moldea la preforma contra las paredes del molde empleandoaire comprimido. Se ventea el aire y se inyecta nitrogeno seco dentro de la preforma moldeada a una temperatura menor que -50grados centigrados para purgar y enfriar la preforma moldeada, manteniendo la presion a 520kpag, por lo menos. La preforma moldeada es mantenida contra el molde durante un tiempo predeterminado durante el cual se templan las superficies interna y externa de la preforma moldeada, la que se transforma en el producto final. Se corta el suministro de nitrogeno y el producto final es liberado del molde.
Patent CR-9362-A (CR)
Title: Articulo absorbente que contiene un gradiente de densidad en por lo menos do sdirecciones, y metodo para la fabricacion del mismo
Inventor: CLAUDIO MALAGONI BUIATTI
IPC: A61F13/15
Filed: 2007-09-04
Abstract: Un articulo absorbente incluye una cubierta permeable a liquido, un material separador, y una estructura absorbente colocada entre la cubierta y el material separador. La estructura absorbente incluye una zona de retencion que tiene un gradiente de densidad variable en por lo menos dos dimensiones y una zona de proteccion que tiene una parte con una densidad menor que la densidad minima del gradiente de densidad en la zona de retencion. La zona de retencion puede ser definida en la primera region de la estructura absorbente teniendo un primer peso base y la zona de proteccion puede ser definida en una segunda region de la estructura absorbente teniendo un segundo peso base que es mayor que el primer peso base.
Patent CR-9555-A (CR)
Title: Composicion de liberacion modificada de al menos una forma de venlafaxina
Inventor: OBEREGGER WERNER
IPC: A61K9/30
Filed: 2007-11-30
Abstract: La presente invencion se refiere a una composicion de liberacion modificada de al menos una forma de venlafaxina, que es una composicion de liberacion controlada retardada. La composicion comprende un nucleo que contiene al menos una forma de venlafaxina seleccionada del grupo que consiste en venlafaxina, un metabolito activo de venlafaxina, una sal farmaceuticamente aceptable de venlafaxina, una sal farmaceuticamente aceptable de un matabolito activo de venlafaxina y sus combinaciones, menos de 10% de un gelificante y un excipiente farmaceuticamente aceptable. La composicion comprende ademas un recubrimiento de liberacion modificada que practicamente rodea el nucleo que proporciona una liberacion controlada retardada de al menos una forma de venlafaxina.
Patent GB-872979-A (GB)
Title: Process for the preparation of dry sizing powder
IPC: C11D15/00
Filed: 1959-01-01
Abstract: A completely saponified dry sizing powder is made by heating a resin to at least its melting point, intimately mixing the resulting melt with a hot aqueous solution of an alkaline saponifying agent until a highly viscous mass is obtained which instantly becomes brittle, and thereafter pulverizing the mass. Paraffin, naphthenic acid or natural or synthetic resins may be added to the melt before saponification. The saponifying agent may be sodium or potassium hydroxide solution, and is preferably used in stoichiometric excess.  In an Example (V) American talloil resin is condensed with maleic anhydride and saponified with sodium hydroxide solution.ALSO:A completely saponified dry sizing powder is made by heating a natural resin or a modified natural resin to at least its melting point, intimately mixing the resulting melt with a hot aqueous solution of an alkaline saponifying agent until a highly viscous mass is obtained which instantly becomes brittle, and thereafter pulverizing the mass.  The resin may be, e.g. rosin, talloil resin, pitch, or mixtures thereof, or modified resins such as maleate-modified resins or hydrogenated rosins.  Paraffin, naphthenic acid or natural or synthetic resins may be added to the melt before saponification.  The saponifying agent may be sodium or potassium hydroxide solution and is preferably used in stoichiometric excess.
Patent GB-729840-A (GB)
Title: Improvements in magnetic electron lenses
IPC: H01J29/68
Filed: 1953-01-01
Abstract: 729,840. Cathode-ray tubes. ' PHILIPS ELECTRICAL INDUSTRIES, Ltd. Jan. 1, 1953 [Jan. 4, 1952], No. 49/53. Class 39 (1). An electron lens consists of permanent magnets 1, 2 which are magnetized in the axial direction or radially. The strength of the field is adjustable by an arrangement 5 which regulates the distance between the magnets, which can be made of crystals of iron oxide and barium, strontium lead and calcium. The lens is enclosed by a screen 4 of soft iron and the electron beam is adjustable by a magnetic plate arranged on one side of a magnet. Specification 708,127, [Group XXXV], is referred to.
Patent JP-S5493868-A (JP)
Title: Waste combusting apparatus
Inventor: OKAJIMA MITSURU
IPC: F23J1/00
Filed: 1978-01-05
Abstract: PURPOSE: To provide a waste combusting apparatus, in which hot gas is brought into contact with both sides of the grate and temperature on the surface of grate is kept higher than that of hot gas, whereby it is enabled to shorten the time required for combusting combustible waste on the grate and to facilitate combustion and evaporation of condensate at the bottom of furnace.  
     CONSTITUTION: Hot-gas inlet 1 is formed at an upper portion in the wall of furnace, and an outlet flue 6 is provided at a lower portion. In the furnace, support A for placing thereon waste to be combusted is disposed downwardly of the hot-gas inlet 1, and another support B for receiving incombustible matters is disposed downwardly of the support A but upwardly of the outlet flue 6. With such an arrangement, combustion of the waste is carried out while keeping the temperature on the surface of grate at a required level. 
     COPYRIGHT: (C)1979,JPO&Japio
Patent JP-H08171432-A (JP)
Title: Reference potential generating circuit, potential detection circuit and semiconductor integrated circuit device
Inventor: OISHI TSUKASA
IPC: G11C5/14
Filed: 1995-01-04
Abstract: PURPOSE: To accurately and quickly generate a stable intermediate potential in a DRAM, etc. CONSTITUTION: A reference potential generation circuit is provided with a reference potential generation stage 10 where four transistors TR 101 to 104 are connected in series, an output stage 12 where two TR 121 and 122 are connected in series, and an output node 14. The node 14 is connected to the gate electrodes of the TR 101 and 104. The TR 102 and 103 are connected to a diode and the drains and gate electrodes of both TR 102 and 103 are connected to the gate electrodes of the TR 121 and 122 respectively.
Patent JP-S5492098-A (JP)
Title: Liquid crystal display panel
Inventor: IGAWA HAJIME
IPC: G09F9/30
Filed: 1977-12-28
Abstract: PURPOSE: To secure an easy alteration of the driving voltage which is applied to each display unit by coating the capacitor or the resistor to the area where the driving signal on the panel glass substrate is supplied.  
     CONSTITUTION: Capacitor 2 is coated on terminal 1 which is drawn out from each segment of the display unit, and the capacitors of different capacities are coated to draw-out terminals 3, 4 and 5 of the display segments for the month, date and time respectively. Accordingly, the driving voltage applied to the liquid crystal can be varied at the area where the driving signal enters the panel although the driving voltage is equal at parts 3W5. 
     COPYRIGHT: (C)1979,JPO&Japio
Patent MX-160347-A (MX)
Inventor: KEELEY JAMES W
IPC: G06F12/08
Filed: 1985-10-01
Abstract: A cache memory unit is constructed to have a two-stage pipeline shareable by a plurality of sources which include two independently operated central processing units (CPUs). Apparatus included within the cache memory unit operates to allocate alternate time slots to the two CPUs which offset their operations by a pipeline stage. This permits one pipeline stage of the cache memory unit to perform a directory search for one CPU while the other pipeline stage performs a data buffer read for the other CPU. Each CPU is programmed to use less than all of the time slots allocated to it. Thus, the processing units operate conflict-free while pipeline stages are freed up for processing requests from other sources, such as replacement data from main memory or cache updates.
Patent YU-7296-A (YU)
Inventor: JOHAN HARMENBERG
IPC: A61K31/58
Filed: 1996-02-06
Abstract: Pronalazak se odnosi na jedan farmaceutski preparat koji sadrži kombinaciju jedne protivvirusne supstance i jednog protivzapaljenjskog glukokortikoida u jednom farmaceutski prihvatljivom nosaču. Farmaceutski preparat se može koristiti za sprečavanje i/ili lečenje herpes virusnih infekcija kod sisara, uključujući i čoveka. Pronalazak se takodje odnosi na primenu kombinacije jedne protivvirusne supstance, prihvatljive za spoljne lokalno nanošenje, i jednog protivzapaljenjskog glukokortikoida za proizvodnju medikamenta za pomenuto sprečavanje ili lečenje infekcija.
Patent DK-27887-A (DK)
Inventor: BOESTEN WILHELMUS HUBERTUS JOS
IPC: C07C231/06
Filed: 1987-01-19
Abstract: The invention relates to a process for the preparation of  alpha -amino- alpha -methylcarboxylic acid amides and  alpha -amino- alpha -cycloalkylcarboxylic acid amides of the formula: <CHEM> where R1 represents alkyl, alkaryl, aryl, alkenyl, heteroalkyl or heteroaryl, whether or not substituted, R2 is methyl, or forms, together with R1, a cycloalkyl group, by conversion of the corresponding amino nitriles using hydrogen peroxide under basic conditions and is characterized in that the conversion takes place in the presence of ammonia. By preference 2-6 moles hydrogen peroxide and 3-12 moles ammonia are used per mole amino nitrile.
Patent DK-40191-A (DK)
Inventor: MACINTYRE IAIN
IPC: A61P43/00
Filed: 1991-03-07
Abstract: Use of amylin, or variants of amylin, as well as amylin agonists, for the treatment of bone disorders, in particular osteoporosis, Paget's disease, and malignant deposits in bone, bone loss of malignancy or endocrine disorders or autoimmune arthritides or immobility and disuse, and in other conditions where a hypocalcaemic effect is of benefit. Functional peptide fragments of amylin, or a variant of amylin or amylin fragment, are provided as well as a soluble amylin, amylin fragments, or variants thereof, or a lyophilized product, or an oral formulation for use alone, or in combination with other agents, including insulin (or insulin-stimulating agents, including but not limited to the sulfonylureas) and estrogens, for the treatment of disorders of bone or calcium balance.
Patent DK-76883-A (DK)
Inventor: LEITNER HARALD
IPC: A01N39/04
Filed: 1983-02-22
Abstract: Storage-stable, herbicidally- active compositions in the form of a concentrating aqueous emulsion comprising 30 to 75% by weight of one or more herbicidally-active phenoxyalkanecarboxylic acid esters, 0.1 to 5 parts by weight referred to the completed emulsion of one or more oil-soluble emulsifiers which are soluble in the esters and have an HLB value of 9 to 16, and 0.1 to 3 parts by weight referred to the completed emulsion of one or more alkali metal salts of single or multiple unsaturated fatty acid taurides or fatty acid alkyl taurides as watersoluble dispersants, the emulsion having a viscosity of 50 to 3,000 mPa.s., a droplet size of 1 to 5  mu m and a pH value of 6 to 9 and a process for the preparation of such emulsion which comprises forming a solution of the active ester and emulsifier and mixing it with an aqueous solution of the dispersant to form a homogeneous mixture.
Patent DK-97784-A (DK)
Inventor: BOTSTEIN DAVID
IPC: C12N15/18
Filed: 1984-02-24
Abstract: A DNA-segment containing a GAL 1 promoter linked to a gene outher than the gagactokinase gene for directing the expression of the gene within a yeast cell is new and may be used in a method of expression of a polypeptide in yeast, comprising introducing a GAL 1 promotor in a DNA-segment, said segment being linked to a gene which may be foreign to the yeast genome in a chromosome or vector in such a fashion that said chromosome or vector is replicated and carried by the cell as part of its genetic information and said gene is expressed. The DNA-segment may be contained in a vector, e.g. a plasmid.
Patent EG-17394-A (EG)
Title: G r f analogs iv
IPC: G01N33/68
Filed: 1985-05-16
Granted: 1992-12-30
Abstract: Human GRF(hGRF), rat GRF(rGRF), porcine GRF(pGRF) and bovine GRF(bGRF) have been earlier characterized and synthetized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in animals, including humans, which have resistance to enzymatic degradation in the body, and which have the sequence: R1-R2-R3-Ala-Ile-Phe-Thr-R8-Ser-R10-Arg-R12-R13-R14-R15-Gln-R17-R18-Al a-Arg-Lys-Le u-R23-R24-R25-Ile-R27-R28-R29-Gln-Gln-Gly-Glu-R34-Asn-Gln-Glu-R38-R39- R40-Arg-R42- R43-R44 wherein R1 is Tyr, D-Tyr, Met, Phe, D-Phe, pCl-Phe, Lou, His or D-His having either a C< alpha >Me or N< alpha >Me substitution or being unsubstituted; R2 is Ala, D-Ala or D-NMA; R3 is Asp or D-Asp; R8 is Ser, Asn, D-Ser or D-Asn; R10 is Tyr or D-Tyr; R12 is Arg or Lys; R13 is Ile or Val; R14 is Leu or D-Leu; R15 is Gly or D-Ala; R17 is Leu or D-Leu; R18 is Tyr or Ser; R23 is Leu or D-Leu; R24 is His or Gln; R25 is Glu, Asp, D-Glu or D-Asp; R27 is Met, D-Met, Ala, Nle, Ile, Leu, Nva or Val; R28 is Asn or Ser; R29 is Arg or D-Arg; R34 is Arg or Ser; R34 is Gln or Arg; R39 is Arg or Gly; R40 is Ser or Ala; R42 is Phe, Ala or Val; R43 is Asn or Arg; R44 is a natural amino acid; provided however that any or all of the residues between R28 and R44, inclusive, may be deleted and provided also that R2 is D-NMA and/or R14 is D-Leu and/or R29 in is D-Arg. Those peptides as well as their nontoxic salts may also be used diagnostically.