Patent SG-11201808554T-A (SG)
Title: Integral membrane protein display on poxvirus extracellular enveloped virions
Inventor: SMITH ERNEST S
IPC: C12N15/863
Filed: 2017-04-21
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date .....0\"\" 26 October 2017 (26.10.2017) WIPO I 111111101111 0 DOI 010111110101111 0 111 OEN MIN 01111111011 OEN (10) International Publication Number WO 2017/184951 Al PCT _ (51) (21) (22) (25) Filing Language: (26) (30) (71) Applicant: VACCINEX, INC. [US/US]; (72) (74) (81) International International International 62/326,501 Patent Classification: A61K 39/12 (2006.01) C12N 15/39 A61K 39/285 (2006.01) C12N 15/62 C07K 16/28 (2006.01) C12N 15/863 Application Number: Filing Date: 21 April 2017 (21.04.2017) Publication Language: Priority Data: 22 April 2016 (22.04.2016) Avenue, Rochester, New York 14620 (US). PCT/US2017/028787 (2006.01) (2006.01) (2006.01) English English US 1895 Mt. Hope Lane, Pitts- 24 Bosworth SCRIVENS, Rochester, New Baptist Hill MOKSA-COR- Drive, Pittsford, Coburn 63101 (US). for every AG, AL, AM, BW, BY, BZ, DK, DM, DO, GM, GT, HN, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) Inventors: ford, kind SMITH, Ernest S.; 101 Brittany New York 14534 (US). PARIS, Mark; Field, Mendon, New York 14506 (US). Maria G. M.; 134 Redcedar Drive, York 14616 (US). KIRK, Renee A.; 7474 Road, Bloomfield, New York 14469 (US). NELISON, Angelica A.; 14 Rainbrooke New York 14534 (US). Agent: HAANES, Elizabeth J. et al.; Thompson LLP, One US Bank Plaza, St. Louis, Missouri Designated States (unless otherwise indicated, of national protection available): AE, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, — = _ = — = = _ = _ = Title: INTEGRAL MEMBRANE PROTEIN DISPLAY ON PDXVIRUS EXTRACELLULAR ENVELOPED VIRIONS FIG . 1 A (57) : This disclosure provides compositions and methods for express- ing and displaying isolated integral membrane proteins (IMPs) or fragments thereof in a native conformation for use in the screening, selecting, and identify- ing of antibodies or antibody-like molecules that bind to a target IMP of interest. = (54) — = = = = Antigen-ECD-A56R ix 1-1 11 in 0\ 71' Ot Il IN Il 0 ei C