Patent SG-11201805237T-A (SG)
Title: Novel 1,2,3 triazole-thiazole compounds, process for preparation and use thereof
Inventor: GOKHALE RAJESH SUDHIR
IPC: A61K31/427
Filed: 2016-12-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization IIIM141101110101011111 HO 1111101110101101 11101111111001111101111 MI International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/109793 Al 29 June 2017(29.06.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 417/06 (2006.01) A61P 17/00 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/4192 (2006.01) A61P 37/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 31/427 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/IN2016/050449 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 20 December 2016 (20.12.2016) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 4189/DEL/2015 21 December 2015 (21.12.2015) IN kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: COUNCIL OF SCIENTIFIC & INDUSTRI- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, AL RESEARCH [IN/IN]; Anusandhan Bhawan,Rafi TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Marg, New Delhi 110 001 (IN). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: GOKHALE, Rajesh Sudhir; CSIR- Institute LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, of Genomics and Integrative Biology, Sukhdev Vihar, Ma- _ thura Road, New Delhi 110 020 (IN). REDDY, Dumbala GW, KM, ML, MR, NE, SN, TD, TG). — Srinivasa; CSIR-National Chemical Laboratory, Dr. Homi Declarations under Rule 4.17: _ Bhabha Road, Pune, (Maharashtra) 411008 (IN). SEETH- - as to applicant's entitlement to apply for and be granted a ARAMSINGH, Balamkundu; CSIR-National Chemical 4.1700) patent (Rule = Laboratory, Dr. Homi Bhabha Road, Pune, (Maharashtra) 411008 GANJU, Parul; CSIR- Institute Genomics — as to the applicant's entitlement to claim the priority of the (IN). of Integrative Biology, Sukhdev Vihar, Mathura Road, earlier application (Rule 4.17(iii)) and New Delhi 110 020 (IN). NATARAJAN, Vivek — Published: Tirunelveli; CSIR- Institute of Genomics and Integrative 21(3)) Biology, Sukhdev Vihar, Mathura Road, New Delhi 110 — with international search report (Art. = 020 (IN). = (74) Agent: SINGH, Manisha; LEX ORBIS, Intellectual Prop- = Practice, 709-710, Tolstoy House 15-17, Tolstoy erty = Marg, New Delhi 110001 (IN). = = = = = = 1-1 M C:r IN C:r © Il IN Il © (54) Title: NOVEL 1,2,3 TRIAZOLE-THIAZOLE COMPOUNDS, PROCESS FOR PREPARATION AND USE THEREOF ei 0 (57) : The present invention discloses a novel 1,2,3 triazole-thiazole compound of formula (I) or pharmaceutically accept- able salt thereof, process for its preparation, its pharmaceutical composition and method for the treatment for stalling vitiligo spread or provide prophylactic benefit to individuals with vitiligo predisposition.