Patent NZ-334377-A (NZ)
Title: use of ketone substituted indanone derivatives for treating cell proliferation disorders and compositions thereof
Inventor: LUM ROBERT T
IPC: C07K5/062
Filed: 1997-09-23
Abstract: The ketone substituted indanone derivatives of formula I are used in the manufacture of a medicament for treating mammals suffering from cell proliferative disorders, infectious diseases, and immunological diseases.  In formula I: R1 to R4 are independently hydrogen, halogen, hydroxyl, thiol, optionally substituted alkyl, alkenyl, alkynyl, alkylalkenyl, alkylalkynyl, alkoxy, alkylthio, acyl, aryloxy, optionally substituted amino, amido or carboxyl, optionally substituted aryl, heteroaryl, optionally substituted heterocycle, heteroalkyl, optionally substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, or cyano;  R5 to R9 are independently hydrogen, halogen, hydroxyl, thiol, optionally substituted alkyl, alkenyl, alkynyl, alkylalkenyl, alkylalkynyl, alkoxy, alkylthio, acyl, aryloxy, optionally substituted amino, amido or carboxyl, optionally substituted aryl, heteroaryl, optionally substituted heterocycle, heteroalkyl, optionally substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, or cyano or R6 and R7 or R8 and R9 can combine to form an oxo group;  X is selected from the group of compounds including hydrogen, -D1, -D2, -E, -D1-E, -D2-E, -D1-D2, or -D1-D2-E;  D1 and D2 are independently J1-C(R10)(R11)-CO-, hydrogen, halogen, hydroxyl, thiol, optionally substituted alkyl, alkenyl, alkynyl, alkylalkenyl, alkylalkynyl, alkoxy, alkylthio, acyl, aryloxy, optionally substituted amino, amido or carboxyl, optionally substituted aryl, heteroaryl, optionally substituted heterocycle, heteroalkyl, optionally substituted cycloalkyl, alkylcycloalkyl or alkylcycloheteroalkyl or can be absent;  E is J2-C(R12)(R13)-CO-R14, hydrogen, halogen, hydroxyl, thiol, optionally substituted alkyl, alkenyl, alkynyl, alkylalkenyl, alkylalkynyl, alkoxy, alkylthio, acyl, aryloxy, optionally substituted amino, amido or carboxyl, optionally substituted aryl, heteroaryl, optionally substituted heterocycle, heteroalkyl, optionally substituted cycloalkyl, alkylcycloalkyl or  alkylcycloheteroalkyl;  R10 to R14 independently hydrogen, halogen, hydroxyl, thiol, optionally substituted alkyl, alkenyl, alkynyl, alkylalkenyl, alkylalkynyl, alkoxy, alkylthio, acyl, aryloxy, optionally substituted amino, amido or carboxyl, optionally substituted aryl, heteroaryl, optionally substituted heterocycle, heteroalkyl, optionally substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro or cyano;  J1 and J2 are independently N-R15, CR16R17, O, S(O)0-2, P(O)0-3;  R15 to R17 are independently hydrogen, halogen, hydroxyl, thiol, optionally substituted alkyl, alkenyl, alkynyl, alkylalkenyl, alkylalkynyl, alkoxy, alkylthio, acyl, aryloxy, optionally substituted amino, amido or carboxyl, optionally substituted aryl, heteroaryl, optionally substituted heterocycle, heteroalkyl, optionally substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, or cyano or R16 and R17 can combine to form a oxo group;  A pharmaceutical composition thereof is also disclosed.