baber/WOPTO huggingface dataset:
Patent DE-69624582-T2 (DE)
Inventor: HEMMI KEIJI
IPC: C07D233/66
Filed: 1996-07-18
Granted: 2003-03-20
Abstract: The present invention relates to a novel fatty acid derivative of the following formula:  wherein R1 is acyl group; R2 is acyl(lower)alkyl; R3 is hydrogen, aryl(lower)alkyl, etc; R4 is acyl(lower)alkyl; and X is -O-,   [wherein R5 is lower alkyl, etc]; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.
Patent DE-69636195-T2 (DE)
Inventor: LAMBALOT RALPH H
IPC: A61P31/04
Filed: 1996-10-11
Granted: 2007-03-29
Abstract: The invention pertains to isolated phosphopantetheinyl transferases, such as the E. coli acyl carrier protein synthase, which transfer a phosphopantetheinyl group onto a substrate. The enzyme can be purified from a natural source, produced recombinantly, or synthetically. Accordingly, the invention provides compositions and kits including phosphopantetheinyl transferases and host cells expressing phosphopantetheinyl transferases. The invention also provides nucleic acids encoding phosphopantetheinyl transferases and vectors comprising such nucleic acids. The invention further provides methods for phosphopantetheinylating a substrate in vitro or in vivo and methods for producing antibiotics in vitro or in vivo.
Patent DE-69706099-T2 (DE)
Inventor: OBERHAUSER THOMAS
IPC: C07D501/00
Filed: 1997-06-05
Granted: 2002-05-02
Abstract: The invention is concerned with a new process for the preparation of compounds of formula <CHEM>     wherein   R<1>   is trityl, acetyl, tetrahydropyranyl or cyclopentyl; R<2>   is hydrogen, hydroxy, lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, lower alkynyl, aryl, aryloxy, aryl-lower alkyl, aryl-lower alkoxy or heterocyclyl or heterocyclyl-lower alkyl; the lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aryl-lower alkyl, aryl, aryloxy, aryl-lower alkoxy, the heterocyclyl moieties being unsubstituted or substituted with at least one group selected from carboxy, amino, nitro, cyano, lower alkyl, lower alkoxy, hydroxy, halogen, -CONR<21>R<22>, -N(R<22>)COOR<23>, R<22>CO-, R<22>OCO- or R<22>COO-, wherein R<21> is hydrogen, lower alkyl, or cycloalkyl; R<22> is hydrogen or lower alkyl; R<23> is lower alkyl, lower alkenyl or a carboxylic acid protecting group; Y   is -S- and Z is -CH2- or Y   is -CH2- and Z is -O-,  by acylation of a compound of formula <CHEM>  with an activated carboxylic acid derivative of formula <CHEM> wherein R<3> is lower alkyl, and R<1>, R<2>, X, Y, Z have the significance given above; and it is further concerned with compounds of formula III.
Patent DE-69708532-T2 (DE)
Inventor: CHAPPET PHILIPPE
IPC: B61D3/12
Filed: 1997-07-15
Granted: 2002-06-27
Abstract: The HGV transporting truck consists of a mobile platform (4) with bogies (3) at each end, of sufficient length to take tractor units with articulated semi-trailers. The distance (E) between its chassis pivots (P) is reduced to a minimum by having them in front of and behind the respective bogies (3). The useful length of each platform is limited to 16.9 m, while the gap between the chassis pivots is of the order of 17.4 m. The floor of the platform can be raised or lowered for loading/unloading and transport by a system of cables or endless screws driven by electric motors and reduction gears.
Patent DE-69709407-T2 (DE)
Inventor: SAULNIER GEORGE
IPC: A61K31/7056
Filed: 1997-08-21
Granted: 2002-05-29
Abstract: The present invention concerns novel amino sugar and related sugar derivatives of indolopyrrolocarbazoles, their use as antitumor agents, and pharmaceutical formulations.
Patent DE-69710597-T2 (DE)
Inventor: THOMPSON JOSEPH
IPC: A61L15/28
Filed: 1997-09-05
Granted: 2002-10-10
Abstract: Materials suitable for use as wound dressings may be made by mixing under low-shear conditions from 2 to 10 parts by weight of polymer solids, the polymer solids consisting of at least 50 percent by weight of a water-swellable cellulose ether fibre and no more than 50 percent by weight of a water-swellable or water-soluble polymer in powder form, with correspondingly from 98 to 90 parts by weight of an aqueous liquor. The aqueous liquor may contain sodium chloride, and may contain from 5 to 30 percent by weight propylene glycol. Materials produced by the method of the invention take the form of viscous pasty materials of good handlability, integrity and absorbency.
Patent DE-69712606-T2 (DE)
Inventor: RUDGE JANETTE MARY
IPC: A61F6/06
Filed: 1997-02-14
Granted: 2002-10-31
Abstract: A condom has a ring (6) adjacent the open end (1) for expanding the condom to a maximum diameter to maintain the open end outside the vagina, and a tubular portion (3) extending between the ring and the closed end is of a size to form a loose fit around the penis and is formed with a series of circumferential grooves (5), e.g. 3 to 5 grooves around 0.8 cm wide and 1.0 cm deep, so that the condom naturally folds in a bellows like manner for the condom to collapse to a substantially flat condition prior to use.
Patent DE-69723389-T2 (DE)
Inventor: SAKELLARIDES JEAN-LOUIS
IPC: F17C1/00
Filed: 1997-10-01
Granted: 2004-05-06
Abstract: The tank has a vented tank casing (1) resting on feet (2) mounted on a base (12). The casing has a skirt (3) and a cover (5) forming an enclosed space filled with an inert gas. The tank can be spherical with the casing formed by a cylindrical skirt (3) enclosing the reservoir and the feet and engaging on the base. The skirt is covered by an annular rim (4) receiving a domed cover with reinforcing ribs (51) having tiles. The top of the cover has an annular cap (6) engaged by the ribs of the cover.
Patent DE-69732831-T2 (DE)
Inventor: COCKBAIN JULIAN
IPC: C08L3/00
Filed: 1997-01-09
Granted: 2006-04-13
Abstract: The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.
Patent DE-69736293-T2 (DE)
Inventor: KEESEE K
IPC: C12P21/08
Filed: 1997-08-19
Granted: 2007-06-14
Abstract: The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.
Patent DE-69815317-T2 (DE)
Inventor: CALDERWOOD JOHN
IPC: A61P35/00
Filed: 1998-03-09
Granted: 2005-04-07
Abstract: Compounds of formula I including pharmaceutically acceptable salts thereof in which R1 represents hydrogen, 2-phenyl-1,3-dioxan-5-yl, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C5-7 cycloalkenyl group or an (optionally substituted phenyl)C1-6 alkyl group wherein the alkyl, cycloalkyl and cycloalkenyl groups are optionally substituted by one or more groups of formula ORA in which RA represents H or a C1-6 alkyl group provided that a group of formula ORA is not located on the carbon attached to nitrogen; R2 represents hydrogen, a C1-6 alkyl group, a C3-8 cycloalkyl group, halo, hydroxy, an (optionally substituted phenyl)C1-6 alkyl group, optionally substituted phenyl or R4; and R3 represents a group of formula (a) in which the phenyl ring is additionally optionally substituted and A represents NH, O, NHSO2, SO2NH, a C1-4 alkylene chain, NHCO, NHCO2, CONH, NHCONH, CO2 or S(O)p in which p is 0, 1 or 2, or A is absent and R5 is attached directly to the phenyl ring; and R5 represents optionally substituted phenyl and, additionally, when A is absent R5 represents a) a phthalimido group optionally substituted by halo or b) a pyrazolylamino group in which the pyrazole ring is optionally substituted by one or more of the following: hydroxy or optionally substituted phenyl; R4 represents a heterocyclic group; are described which are useful in treating proliferative diseases and disorders of the immune system in mammals. Processes to prepare these compounds and pharmaceutical compositions containing these compound are also described.
Patent DE-69828293-T2 (DE)
Inventor: SPINOZA MARC HOWARD
IPC: A61M16/04
Filed: 1998-08-20
Granted: 2006-06-01
Abstract: A Method of securing a line (25) to a patient or of adjusting the position of a line (25) thus secured comprises elongating and narrowing a sleeve (20) applied to the line to grip the line and resist movement of the line along its longitudinal axis with respect to the sleeve. Also disclosed is a fastener (19) for securing a line (25) to a patient, the fastener comprising a sleeve (20) of variable length capable when lengthened of gripping the line.
Patent DE-69837387-T2 (DE)
Inventor: INTURRISI CHARLES E
IPC: A61K31/135
Filed: 1998-01-21
Granted: 2007-12-13
Abstract: The present invention relates to a method of treating pain in a subject having a NMDA recptor which includes administering d-methadone, d-methadol, d-alpha-acetylmethadol, l-alpha-acetylmethadol, d-alpha-normethadol, l-alpha-normethadol, pharmaceutically acceptable salts thereof, or mixtures thereof, to the subject under conditions effective for the substance to bind to the NMDA receptor of the subject. The present invention further relates to a method of treating tolerance and physical dependence in a subject and a method of binding to a NMDA receptor.
Patent DE-69904941-T2 (DE)
Inventor: SOE BORCH
IPC: A23L29/00
Filed: 1999-07-20
Granted: 2003-10-30
Abstract: There is provided use of a conversion agent to prepare from a food material a foodstuff comprising at least one functional ingredient, wherein the at least one functional ingredient has been generated from at least one constituent of the food material by the conversion agent.
Patent DE-69912276-T2 (DE)
Inventor: MAHDI SYED Z
IPC: C08G18/24
Filed: 1999-04-27
Granted: 2004-07-22
Abstract: In one embodiment the invention is An adhesive composition comprisinga) a polymer having a flexible backbone and a reactive moiety capable of cross-linking,b) a particle comprising an active agent encapsulated in an encapsulating agent wherein the active agent comprises a catalyst for cross-linking of the reactive moiety, a curing agent for the reactive moiety, an accelerator for the curing reaction or a mixture thereof; and the encapsulating agent comprises a side chain crystallizable polymer wherein the active agent is not substantially extractable from the particle at ambient conditions in a first extraction after particle formation.This composition is used in binding two subtracters together.
Patent DE-69912956-T2 (DE)
Inventor: SPAANS COENRAAD JAN
IPC: C08G18/80
Filed: 1999-06-04
Granted: 2004-11-11
Abstract: The invention is directed to a novel biomedical polyurethane based on diisocyanate linked polyester polymer and diol components, said diol component having a uniform block-length.
Patent DE-69921504-T2 (DE)
Inventor: MINSHULL JAMES
IPC: B64F5/00
Filed: 1999-12-17
Granted: 2005-02-24
Abstract: The jig loading system comprises an assembly of straps 10 for attachment to a support member 14 so as to hang downwardly in spaced apart positions. Each strap 10 has a releasable holder 16 thereon for supporting aircraft stringers 18 at spaced apart positions to enable the stringers to be positioned at the jig 24 for loading thereon. The holders 16 are loop-like and are openable and closeable by means of releasable spring clips 28.
Patent DE-69936446-T2 (DE)
Inventor: YOUNG ANDREW A
IPC: A61K38/00
Filed: 1999-02-05
Granted: 2008-03-06
Abstract: Methods for increasing urine flow are disclosed, comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. Methods for increasing urinary sodium excretion and decreasing urinary potassium concentration are also disclosed. The methods are useful for treating conditions or disorders associated with toxic hypervolemia, such as renal failure, congestive heart failure, nephrotic syndrome, cirrhosis, pulmonary edema, and hypertension. The present invention also relates to methods for inducing an inotropic response comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. These methods are useful for treating conditions or disorders that can be alleviated by an increase in cardiac contractility such as congestive heart failure. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
Patent HU-E031256-T2 (HU)
Title: Salts of aza-bicyclic di-aryl ethers and methods to make them or their precursors
Inventor: MARTERER WOLFGANG
IPC: A61P25/28
Filed: 2012-07-12
Abstract: The present invention relates to a process for the production of a compound of formula I ((R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane) or a salt thereof and to a process for the production of a compound of formula II (5-chloro-2-(4-methylphenyl)pyridine ) or a salt thereof, which is used as an intermediate in the preparation of the compound of formula I.
Patent TR-200000275-T2 (TR)
Title: Dokuma tezgahı koşumuna sahip jaquard dokuma tezgahı
Inventor: SPEICH FRANCISCO
IPC: D03C/
Filed: 1998-05-27
Abstract: Dokuma tezgahi kosumu, üst kosum levhasinin (3) deliklerinden (4) ortaklasa geçerken alt kosum levhasinin (5) deliklerinden (4) tek tek geçirilen kosum kordonlarina (2) ve kosum kordonlarini jacquard tertibati ile baglamaya yarayan sustali kancalara (1) sahip bir üst ile bir alt kosum levhasindan (3,5) olusan bir üst kisim ile ters çekis birimlerine ve ip kollarina sahip bir alt kismi içerir.Kosum kordonlari, atki yönü A'da üst kosum levhasindaki kosum kordonlarinin sirasi alt kosum levhasindaki kosum yinelemelerinde ayni sekilde çogaltilacak ve üst kosum levhasindaki  deliklerinden birinden geçen kisimlar üst kosum levhasindaki komsu deliklerden geçen kisimlardan en az biriyle çapraz gelecek sekilde düzenlenmistir. Bu düzen sayesinde sarf edilen kosum kordonlarinin sayisi azaltilirken dokuma tezgahi hizlandirilir.
Patent TR-200102706-T2 (TR)
Title: Bir küvet taşıyıcı ve bir küvet taşıyıcı içine takılmış küvet gövdesinin montaj yöntemi
Inventor: HORN MARKUS
IPC: A47K3/16
Filed: 2000-03-23
Abstract: Bulus bir kuvet tasiyici içine yerlestirilmis örnegin bir banyo küveti veya bir dus küveti gibi kuvet gövdesiyle ilgili olup, montaj açisindan avantajli, oturakli bir çözüm için küvet tasiyici kaidesinin ayri ayaklar (5) sergileyen, çerçeve biçiminde kaide altligi olarak yapilmis ve boru hatlarinin (11) baglanmasi için çok sayida yan geçitlere sahip olmasini önermektedir.
Patent TR-200200245-T2 (TR)
Title: Lastik montaj aygıtı
Inventor: SALA ADAMO
IPC: B29D30/32
Filed: 2000-06-27
Abstract: Üzerine, silindirik biçimde bir karkas kovaninin oturuldugu, birbirine eksenel sekilde hareket ederek yaklasabilen iki yaridan yapilmis bir lastik montaj aygiti.Her yari, her biri, karkas kovaninin bir anular sabitleme yapisi yakinina takilmasi için bir radyal açidan genisleyebilen tutma elemani ile donatilmis radyal sektörleri içermektedir. Tutma elemanlarina birlesik destekleme elemanlari, bir silindirik biçimde uzatilmis karkas katlari için bir silindirik destekleme yüzeyi olusturarak, kusak-alti seritlerin uygulanisini kolaylastirmaktadir.Çember boyunca dagitilmis kollar içeren yukari çevirme cihazlari karkas kovaninin yan kenarlarini, yarilarin karkas kovanina simit sekilli bir biçim vermek üzere birbiri yakinina hareket ettirilmesinden sonra anular sabitleme yapilarinin etrafinda yukariya dogru çevirmekte ve onu bir taban yüzü bandi ile donatilmis bir kusak paketine takmaktadir.
Patent DE-602004000053-T2 (DE)
Inventor: UEDA MITSUO
IPC: H02P25/02
Filed: 2004-02-23
Granted: 2006-06-14
Abstract: An apparatus for driving a linear vibration motor that employs a proper motor thrust constant value corresponding to each linear vibration motor at position calculation for obtaining the position of the mover of the linear vibration motor, thereby increasing the accuracy of the position calculation. This motor driving apparatus includes a motor driver for applying a DC voltage to the linear vibration motor, and a thrust detection unit for detecting a thrust of the mover, which is generated by the application of the DC voltage to the linear vibration motor, and calculates the thrust constant of the linear vibration motor according to an arithmetic operation of dividing the mover thrust detected by the thrust detection unit, by a value of a DC current that is supplied to the linear vibration motor due to the application of the DC voltage to the linear vibration motor. <IMAGE>
Patent DE-602004008895-T2 (DE)
Inventor: EDWARDS PAUL JOHN
IPC: A61K31/4015
Filed: 2004-12-09
Granted: 2008-06-19
Abstract: The invention relates to compounds of formula (I) <CHEM> wherein Z, R<1-5>, X, n, A<1> and A<2> have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament.
Patent DE-602005004653-T2 (DE)
Inventor: VAN STEVENDAAL UDO
IPC: G01N23/20
Filed: 2005-03-15
Granted: 2009-01-29
Abstract: In CSCT, an exact reconstruction of a scattering function for each voxel is not known for polychromatic primary radiation. According to an exemplary embodiment of the present invention, a beam hardening compensation is performed prior to reconstruction allowing to perform a quasi-exact reconstruction on the basis of the primary radiation mean attenuation values are determined, from which an equivalent water thickness is derived. From the equivalent water thickness an energy shift is calculated, which is used to correct the initial mean energy of the scatter radiation. Furthermore, a CT reconstruction may be performed prior to a CSCT reconstruction allowing for a beam-hardening correction. Advantageously, this may allow for an improved image quality and an improved resolution of the scatter function.
Patent DE-60221830-T3 (DE)
Inventor: BOND ERIC
IPC: D04H1/54
Filed: 2002-05-09
Granted: 2012-01-12
Abstract: The present invention is directed to multicomponent fibers. The fibers may be in a side-by-side, sheath-core, segmented pie, islands-in-the-sea configuration, or any combination of configurations. Each component of the fiber will comprise destructurized starch and/or a thermoplastic polymer. The present invention is also directed to nonwoven webs and disposable articles comprising the multicomponent fibers. The nonwoven webs may also contain other synthetic or natural fibers blended with the multicomponent fibers of the present invention.
Patent DE-69302483-T3 (DE)
Inventor: VANBRAEKEL ALEXANDRE
IPC: A61K8/02
Filed: 1993-09-09
Granted: 2001-07-26
Abstract: A sampling device for perfume comprises a perfume sample support film (1) to be stuck to a presentation sheet (3) such as paper, cardboard, at least one perfume sample (5) in the form of a gel applied to the support film (1) and a removable protective film (6) applied to this sample which, when removed from the support film (1), causes the perfume sample (5) to be removed from the support film (1) due to its adhesion to said protective film (6). This allows the perfume to be tried by application to the skin.
Patent DK-1140810-T3 (DK)
Inventor: DELARGE JACQUES
IPC: C07C335/42
Filed: 2000-01-12
Granted: 2004-07-19
Abstract: Benzene-sulphonamide derivatives complying with the general formula (I):in which the different symbols have different meanings, their optical isomers and the salts pharmacologically acceptable of these derivatives, as well as their uses for drug manufacture and as radiolabelled pharmacological tools of the thromboxan A2 receptors.
Patent DK-1208089-T3 (DK)
Inventor: MARTIN THOMAS
IPC: C07D245/02
Filed: 2000-08-09
Granted: 2005-02-14
Abstract: A compound of formula Iin which M, A1, A2, A3, A4, A5, A6, B1, B2, B3, B4, B5, B6, K1, and K2 are defined herein and are novel effective tryptase-inhibitors.
Patent DK-1201700-T3 (DK)
Inventor: HIYOSHI SATOSHI
IPC: C09D5/16
Filed: 2001-10-23
Granted: 2003-09-15
Abstract: A (poly)oxyalkylene block silyl ester copolymer comprising silyl ester copolymer block units (A) and block units (B), the silyl ester copolymer block units (A) comprising (a) component units derived from a polymerizable unsaturated carboxylic acid silyl ester, and (b) polymerizable unsaturated monomer units other than the component units (a), the block units (B) derived from a mercapto compound represented by the following formula (1) or (2), and further an antifouling paint comprising the (poly)oxyalkylene block silyl ester copolymer. <CHEM>   <CHEM> wherein R<1> represents a hydrocarbon group or ether-bond-containing hydrocarbon group having a valency of 1 or higher and having 1 to 30 carbon atoms; R<2> represents a bivalent hydrocarbon group having 1 to 30 carbon atoms or a group of the formula -CH(R<3>)- wherein R<3> represents a group of the formula R<4>-O-R<5>, R<4> representing a bivalent hydrocarbon group having 1 to 30 carbon atoms, and R<5> representing a monovalent hydrocarbon group having 1 to 30 carbon atoms; X represents: <CHEM> n is an integer of 1 to 5; m is an integer of 1 to 100; 1 is an integer of 1 to 5; k is an integer of 0 to 100; a is an integer of 0 or 1; j is an integer of 1 to 50; and i is the valency of R<1>. The present invention enables forming an antifouling coating film which exhibits less cracking tendency, excellent adherence so as to ensure less peeling tendency and desirably controlled hydrolysis rate so as to be excellent in antifouling performance (antifouling activity), antifouling properties, in particular, antifouling properties in highly fouling environment and long-term antifouling properties. <IMAGE>   <IMAGE>
Patent DK-1272287-T3 (DK)
Inventor: GILLET FRANCOIS
IPC: B07C3/00
Filed: 2001-04-02
Granted: 2007-04-10
Abstract: In order to eliminate addressing errors on postal articles in a process ( 8, 10 ) of sorting, routing, and delivery performed by a postal operator on mail articles ( 3' ) handed over to the operator by a sender of mail articles constituting a client of the postal operator, respective mail article identity numbers (I) are generated for the mail articles to be processed in the sorting, routing, and delivery process, said identity numbers (I) being applied to the respective mail articles in machine readable form ( 5 ) and being recorded in an electronic file (F) in association with data (A) giving the postal addresses of the mail articles. These mail article identity numbers (I) or "extended client codes" are generated by the mail article sender and they are applied by the sender to the mail articles prior to handing them over to the postal operator. The file (F) containing the mail article identity numbers in association with the data giving postal addresses is also prepared by the sender of mail articles and is transmitted by the sender to the postal operator.
Patent DK-1267796-T3 (DK)
Inventor: JOZIAK MARILOU T
IPC: A61K8/04
Filed: 2001-03-30
Granted: 2007-03-12
Abstract: A dental fluoride foam composition comprising a foamable fluoride containing composition that is packaged in a foam generating container, the composition being comprised mainly of, an aqueous solution of a water soluble fluoride ion releasable salt, a taurate surfactant whereby the composition when dispensed from the container into the trough of a dental tray forms a low density, rapidly collapsible foam which substantially liquefies in about 1 minute after being dispensed from the foam generating container and placed in contact with a patients teeth.