Patent AU-2015201538-A1 (AU)
Title: Silk fibroin systems for antibiotic delivery
Inventor: KAPLAN DAVID L
IPC: A61P31/00
Filed: 2015-03-25
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization IN International Bureau (43) International Publication Date H(10) International Publication Number 9 December 2010 (09.12.2010) PCT W O 2010/141133 A2 (51) International Patent Classification: (74) Agents: RESNICK, David et al.; Nixon Peabody LLP, A6L 27/40 (2006.01) A6L 27/54 (2006.01) 100 Summer Street, Boston, MA 02110 (US). A0 271/36 (2006.01) A6JP 31/00 (2006.01) (81) Designated States (unless otherwise indicated, for every C07K 141435 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, PCT/US2010/026190 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, ) .a DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (22) International Filng Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 4 March 2010 (04.03.2010) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (25) Filing Language: English ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (26) Publication Language: English SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (30) Priority Data: TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 61/157,366 4 March 2009 (04.03.2009) US (84) Designated States (unless otherwise indicated, for every (71) Applicant (for all designated States except US): kind of regional protection available): ARIPO (BW, GH, TRUSTEES OF TUFTS COLLEGE [US/US]; Ballou GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, Hall, Medford, MA 02155 (US). ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, (72) Inventors; and ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (75) Inventors/Applicants (for US only): KAPLAN, David, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, L. [US/US]; 46 Pond Street, Concord, MA 01742 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, PANILAITIS, Bruce [US/US]; 218 Foster Road, Tewks- ML, MR, NE, SN, TD, TG). bury, MA 01876 (US). PRITCHARD, Eleanor, M. [US/ US]; 116 College Avenue, Apartment #1, Somerville, MA Declarations under Rule 4.17: 02144 (US). OMENETTO, Fiorenzo [US/US]; 22 - as to applicant's entitlement to apply for and be granted Prospect Street, Wakefield, MA 01880 (US). AXEL- a patent (Rule 4.17(ii)) RAD, Jordan [US/US]; 70 Lincoln Street, Apartment - as to the applicant's entitlement to claim the priority of L4 11, Boston, MA 02111 (US). the earlier application (Rule 4.17(iii)) [Continued on next page] (54) Title: SILK FIBROIN SYSTEMS FOR ANTIBIOTIC DELIVERY -U Figure -vt ioi- spees ni Scaffold cic-C- Layec cn Scaffo~d ar Entmiedid n Sciffot __ Time (Hours, __ Figure I (57) Abstract: The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making antibiotic -containing silk scaffold, methods of stabilizing Antibiotics in silk scaffolds, and methods for preventing or treating microbial contamination using the antibiotic -containing com positions. Various methods may be used to embed the antibiotic(s) into the silk fibroin-based compositions. The antibiotic-con taining compositions of the invention are particular useful for stabilizing antibiotics, preventing bacterial infections, and for medi cal implants, tissue engineering, drug delivery systems, or other pharmaceutical or medical applications.