Patent SG-11201903340T-A (SG)
Title: Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules
Inventor: PICKER LOUIS
IPC: C12N15/86
Filed: 2017-10-18
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property (43) International Publication 26 April 2018 (26.04.2018) 0 Ill 110 1 0 01 1101 11 III 1011 1101 11111 0 il 1111101M 110 liii Publication Number 2018/075591 A8 CORRECTED VERSION International Bureau 0 --, i 1 11111 I 011111 Organization 11101 0 10 11111 (10) International Date ......°\"\" WO WIP0 I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) Inventors: NELSON, Jay; 0690 International Patent Classification: C12N 15/86 (2006.01) A OK A61K 39/21 (2006.01) International Application Number: International Filing Date: Publication Language: Priority Data: 62/409,840 18 October 2016 (18.10.2016) Applicant: OREGON HEALTH UNIVERSITY [US/US]; Office & Business, Development, 0690 SW Bancroft Street, Mail Code L106tt, Portland, OR 97239-3098 18 October 2017 (18.10.2017) OR 97007 (US). FRUEH, 48/00 (2006.01) Portland, OR 97229 Vista Terrace, Portland, OR 97210 (US). (74) Agent: CALVO, Paul PCT/US2017/057106 & Fox P.L.L.C., 1100 New York Avenue N.W., Washing- ton, District of Columbia 20005-3934 (US). (81) Designated States English kind of national protection AO, AT, AU, AZ, BA, English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, HR, HU, ED, IL, IN, US KR KW, KZ, LA, LC, & SCIENCE MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, of Technology Transfer OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, (US). TR, TT, TZ, UA, UG, Sw Bancrift Street, Port- (84) Designated States Daniel; 2836 Nw Ada- kind of regional protection PICKER, Louis; 25 GM, KE, LR, LS, MW, (US). HANCOCK, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Portland, OR 97239 TM), European (AL, Klaus; 1980 Nw 113th Avenue, (US). HANSEN, Scott; 3050 Nw Valle A. et al.; Sterne, Kessler, Goldstein (unless otherwise indicated, for every available): AE, AG, AL, AM, BB, BG, BH, BN, BR, BW, BY, BZ, FI, GB, GD, GE, GH, GM, GT, HN, IR, IS, JO, JP, KE, KG, KH, KN, KP, LK, LR, LS, LU, LY, MA, MD, ME, SL, SM, ST, SV, SY, TH, TJ, TM, TN, US, UZ, VC, VN, ZA, ZM, ZW. (unless otherwise indicated, for every available): ARIPO (BW, GH, MZ, NA, RW, SD, SL, ST, SZ, TZ, AT, BE, BG, CH, CY, CZ, DE, DK, GR, HR, HU, 1E, IS, IT, LT, LU, LV, land, OR 97239 (US). MALOULI, gio Way, Hillsboro, OR 97124 (US). Nw 95th Avenue, Portland, OR 97229 Meaghan; 0690 Sw Bancroft Street, (US). SACHA, Jonah; 7381 Sw 180th Terrace, Beaverton, EE, ES, FI, FR, GB, (54) PLEX f selection Title: CYTOMEGALOVIRUS VECTORS ELICITING T CELLS RESTRICTED BY MAJOR HISTOCOMPATIBILITY COM- E MOLECULES 68-1 RhCMV/gag (Rh157.5/4-deleted) vector: Rh24932 E g BE M MirggrilE102E1D .. Rh25029 = Fa iR .474 :gi . ti - ' 77 :5 L' r e 2 •04-5714E143—N-iti-&-U Rh299 2 L=,. ;i :;-: i; t , :,,i = . ,‘,. =._ . Mt] Si :;.4: ::: Rh29923 t..4 4. :4.t , ':: .A. t F., UL128 deleted; strain 68-1.2 RhCMV/gag (UL130 repaired) vaccine: Rh27922 L.: A Rh 28399 -ifil---gg-g-M-Ciaii--ffi---g---0--&-C?----- •:: F.4ri \"s;' . 4•: , it , .., 4ii. ' , 1.4. • F. F E •.! F ;F Fit 1.4 , \" .4 ::.• FF. ;IL II -- - I I -3:: MI ;..; I 1: I - II IL - igiii---gii---E :I ;;;„ I.:= :I: MI .. .1 14}E-41}-ffi--D- UL130 deleted; strain 68-1.2 RhCMV/gag (UL128 repaired) vaccine: Rh28400 -kw 4 0 El• 4:J U Oli-{:}-44-{1}---1-U- - -El-al.]it:I -LE El R-6 1 2----C-M1. =.01 4 4-1Ert12----E4N Rh28405 Egi I El 1 P &CO Ell M M gl ME 0----M-0 El P rfP Ell 0 Pg 07 0 WI al ['.----M-----E-M- Strain 68-1.2 RhCMV/gag (UL128/UL130 repaired) vaccine: Rh28412 II GC Il kin kin IN 0 -...... oe (57) Il O more I I I II I III II 1 I I I Rh28617 El 0 a] 110 ED al 0 Dal 0 ]—I 11--WHIDr0-10---0 III II 0 0 0 i I ; 1 I \"1 .1 1 1 ii 1 1 1 0 MHC-la restricted 1 MHC-E restricted g MHC.:-11 restricted i Indeterminate : Disclosed are CMV vectors microRNA regulatory elements (MRE) of different CD8+ T cell responses - CD8+ T cells restricted by MHC-Ia, MHC-II, or 25 50 75 Consecutive SIVmac 239 gag 1 5mers (71 a.a. overlap) FIG. 'I that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or that restrict expression of the CMV Immunization 100 125 with the disclosed CMV vectors allow by MHC-E. C [Continued on next page] WO 2018/075591 A8 I 11111 1111111111111111 11111 11111 11111 111110111 11111 II III 11111 11111 1111101111111111111 11111111 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (48) Date of publication of this corrected version: 04 April 2019 (04.04.2019) (15) Information about Correction: see Notice of 04 April 2019 (04.04.2019)