baber/WOPTO huggingface dataset:
Patent DK-3071570-T3 (DK)
Inventor: BEHENNA DOUGLAS CARL
IPC: C07D519/00
Filed: 2014-11-10
Granted: 2018-08-13
Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, G, ring A, ring B, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, and m are defined herein. The novel purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
Patent DK-0480100-T3 (DK)
Inventor: TAMAI SATOSHI
IPC: C07D231/04
Filed: 1990-12-28
Granted: 1996-11-18
Abstract: Novel and improved simple process for preparing carbapenem compound, (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo [1,2-a][1,2,4]triazolium-6-yl)]thio-6-[(R)-1-hydroxyethyl]-1-methyl-ca rbapenem-3-carboxylate represented by the following formula: <CHEM>   This compound may be prepared by using a mercapto reagent, 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium derivative of the following formula: <CHEM> wherein X<(-)> is an anion charge. g a
Patent DK-0458845-T3 (DK)
Inventor: FALHOLT PER
IPC: C11D17/06
Filed: 1990-02-16
Granted: 1993-03-29
Abstract: The detergent additive granulate comprises a core with a primary detergent additive surrounded by a shell comprising a secondary detergent additive, a binder, and granulating agents, and optionally a filler, and a protective coating between the core and the shell, whereby the shell comprises cellulose fibres or artificial fibres, and whereby the core facultatively comprises cellulose fibres or artificial fibres. The detergent additive granulate exhibits a high physical strength, and the primary and secondary detergent additives are effectively separated from each other and/or from harmful environmental factors. The detergent additive granulate is produced by introduction of the components thereof into a granulating drum. This method of production is easily controllable and adapted for an industrial scale.
Patent DK-0475979-T3 (DK)
Inventor: PEDERSEN BORGE CHRISTIAN
IPC: C12M1/26
Filed: 1990-05-22
Granted: 1993-06-07
Abstract: A diaphragm valve (2) comprising valve seats (11, 12) describing a sector of a sphere providing a complete closure of the inlet (13) and the outlet (14), when the diaphragm (16) assumes the shape of a spherical segment. The valve permits easy and complete cleaning and sterilization and is especially suited for sampling.
Patent DK-0445518-T3 (DK)
Inventor: BRINKMANN DIRK DIPL-ING
IPC: B23B5/32
Filed: 1991-01-26
Granted: 1994-07-18
Abstract: In an underfloor wheel lathe 1 for reprofiling the wheels 28, 29 of railway wheel sets, with two machine units 3, 4 which are each allocated to a wheel 28, 29 of the wheel set 30 and of which each has a machine column 6, 7, a swivel head 8, 9, an axlebox supporting device 10, 11, two friction rollers 36, 37, 38, 39 which can be pressed against a wheel of the wheel set 30, and a friction-roller carrier 40, 41, at least one of the two friction rollers of each friction-roller carrier 40, 41 being drivable, and each friction-roller carrier 40, 41 being pivotable about a pivot axis 42, 43 movable in the centre plane 44 of the underfloor wheel lathe 1, an increase in the cutting capacity without brake devices acting on the friction-wheel carriers 40, 41 is made possible by two pressure devices 58, 59, 60, 61 being linked to each friction-wheel carrier 40, 41, which pressure devices 58, 59, 60, 61 produce torques 62, 63 acting in opposite direction with regard to the associated pivot axis 42, 43.
Patent DK-0481742-T3 (DK)
Inventor: CLIFFE IAN ANTHONY
IPC: A61K31/4409
Filed: 1991-10-16
Granted: 1997-12-29
Abstract: Piperazine derivative of formula <CHEM> and the pharmaceutically acceptable acid addition salts, where A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups, m is 0, 1 or 2, R is hydrogen or lower alkyl, R<1> is aryl or a mono- or bicyclic heteroaryl radical, R<2> is hydrogen or lower alkyl, R<3> is a heteroaryl radical, R<4> is hydrogen, lower alkyl or aryl, and R<5> is hydrogen, lower alkyl, cycloalkyl, cycloalkyl(lower)alkyl, aryl, or aryl(lower)alkyl or R<4> and R<5> together with the nitrogen atom to which they are both attached represent a saturated heterocyclic ring which may contain a further hetero atom are 5-HT1A- binding agents and may be used, for example, as anxiolytics.
Patent DK-0550439-T3 (DK)
Inventor: LIBURDI JOSEPH
IPC: B22F7/04
Filed: 1990-08-28
Granted: 1998-05-25
Abstract: To repair or join sections of a metal article, matching metal powder is sintered in the solid state to form a porous structure in the joint. A layer of matching powder, modified to incorporate melting point depressants such as boron and silicon is subsequently added to the surface of the sintered region. The joint is processed at a temperature where the modified layer melts while the sintered layer and base metal remain solid. The modified material flows into the sintered layer by capillary action and promotes liquid phase sintering, resulting in a dense joint with properties approaching those of the base metal.
Patent DK-0501371-T3 (DK)
Inventor: PLOEGER CORNELIUS
IPC: F21V25/04
Filed: 1992-02-24
Granted: 1995-05-29
Abstract: An elongated lighting fixture has a lighting fixture housing (11) and a trough (12) covering the latter and made from a transparent material. A socket holder (13) for at least one fluorescent lamp (16) is accommodated inside the lighting fixture housing (11), and the trough (12) is locked in the closed position by means of a slide displaceable in the longitudinal direction of the housing (11). In addition, there is provided inside the lighting fixture housing (11) a switch (27) which is opened upon unlocking of the trough (12), so that the flow of current to the fluorescent lamp is interrupted. In order to prevent actuation of the slide (37) turning on the switch, a drive element (29) is provided which actuates the switch (27) and has a lug (33) provided with a latching element. A mating piece corresponding to the latching element is provided on the socket holder, so that the drive element (29) is retained in the off position after opening of the trough. The latching element on the lug (33) is a cutout (34) and that on the socket holder (13) is a nose (23), or vice versa, which engages in the cutout (34) in the locked state. Upon insertion of the trough (12), the lug (33) is brought out of engagement with the nose (23) by means of a projection (35) integrally formed on the trough. <IMAGE>
Patent DK-0575412-T3 (DK)
Inventor: VADGAMA PANKAJ MADGANLAL
IPC: C12M1/34
Filed: 1992-03-12
Granted: 1996-01-15
Abstract: Analytical sensor devices incorporating a permselective medium immobilised as a continuous liquid or gel phase barrier between sample and detector. The barrier is electrically insulating, impermeable to charged non-lipophilic species, selectively partitions lipophilic species diffusing through it, and its selectivity can be controlled or optimised by pH adjustments. The preferred barrier form has the permselective medium (e.g. a lipid or ester) immobilised by incorporation as plasticiser in a polymer (especially PVC). The preferred detector is an electrode, especially of non-potentiometric type. The sensor can be used to detect components as such or indirectly by allowing them to react to produce other materials to which the detector responds (e.g. an ionic species or an ion concentration or activity change) and is also applicable to detecting neutral or small uncharged hydrophilic species, e.g. hydrogen peroxide -- especially that formed by enzyme action in the sensor or detector system. <IMAGE>
Patent DK-0590082-T3 (DK)
Inventor: FREIER SUSAN M
IPC: C12Q1/68
Filed: 1992-06-11
Granted: 1999-11-08
Abstract: Methods are provided for preparing antisense oligonucleotides which take advantage of RNA secondary and tertiary structure and for preparing antisense oligonucleotides which specifically hybridize to regions of RNA secondary and tertiary structure by comparing the affinity of the oligonucleotide for a structured RNA target to the affinity of the oligonucleotide for a length-matched oligonucleotide complement, and selecting an oligonucleotide having an affinity for the structured target which is not less than one thousandth of its affinity for the length-matched oligonucleotide complement. Oligonucleotides are also disclosed which are specifically hybridizable with regions of H-ras RNA having secondary and tertiary structure.
Patent DK-0569801-T3 (DK)
Inventor: KOCH GEORG
IPC: H05K1/09
Filed: 1993-04-30
Granted: 1998-02-23
Abstract: The non-reactive resistors of the SMD assembly are implemented, for space-saving construction, as screen-printed resistors (3) in that a resistance paste is applied to a circuit board base material by means of a screen or a template and is subsequently cured by the supply of heat. For a space-saving construction of a multilayer circuit board (5) it is provided that resistive, inductive and/or capacitive components (3) which are implemented using printing technology are printed on in the inner layers of circuits boards (1) which are provided with conductor tracks on both sides, and SMDs are arranged on the outer layers. The circuit boards are arranged horizontally and are pressed with the mutually facing inner side on an intermediate layer (4) consisting of elastic insulating material. <IMAGE>
Patent DK-0561448-T3 (DK)
Inventor: TER HORST ROEL
IPC: H04N7/46
Filed: 1993-03-05
Granted: 1999-05-31
Abstract: Known systems based on pyramidal video-coding and video-decoding code and decode with insufficient efficiency. By feeding back, in each layer of the coding system, the data processing means present in the layer via memory means, only so-called difference pictures are coded, which increases the efficiency considerably. The decoding system should then similarly be provided with fed-back memory means and, as a result, normally attains a very complex scope, which is avoided, however, if in the coding system coupling between two adjacent layers takes place in the highest layer thereof with two different points of the feedback loop. <IMAGE>
Patent DK-0599547-T3 (DK)
Inventor: QUIRK RICHARD
IPC: B01D53/56
Filed: 1993-11-18
Granted: 1998-02-09
Abstract: A method of operating a regenerative glass furnace for melting glass for the manufacture of shaped glass articles so as to minimise emission of NOx in waste gases leaving the furnace, the furnace having sealed regenerators which act as heat exchangers, the method comprising supplying fuel in excess of that required for stoichiometric combustion to ensure that glass of the required quality at the required production rate is obtained, and that the waste gases leaving the furnace through the regenerators contain combustible material, and reacting said combustible material with sufficient air to ensure that the waste gases exiting to atmosphere contain permissible levels of combustible material and contain permissible levels of NOx. Alternatively, the furnace may be operated at substantially stoichiometric conditions and fuel is supplied to waste gases as they leave the melting chamber. The invention also relates to a regenerator glass furnace for use in the method. The invention further provides a method of reducing the emissions of CO in waste gases leaving a cross-fired regenerative glass furnace for melting glass for the manufacture of shaped glass articles, the furnace having sealed regenerators which act as heat exchangers, the method comprising removing CO from the waste gases in the regenerator by combusting CO in around 8% excess air, based on the combustion air for the supplied fuel, at a temperature greater than 650 DEG C. <IMAGE>
Patent DK-0663945-T3 (DK)
Inventor: FRIESE CARSTEN
IPC: C11D3/48
Filed: 1993-09-30
Granted: 1997-08-18
Abstract: PCT No. PCT/EP93/02670 Sec. 371 Date May 4, 1995 Sec. 102(e) Date May 4, 1995 PCT Filed Sep. 30, 1993 PCT Pub. No. WO94/09105 PCT Pub. Date Apr. 28, 1994A clear aqueous disinfectant compositon containing the reaction product of (a) an N-substituted propylenediamine corresponding to formula I: R1,-NH-CH2-CH2-CH2-NH2 (I) in which R1 is a linear alkyl radical containing 12 to 14 carbon atoms, and (b) a compound corresponding to formula II: R2-O-CO-CH2-CH2-CH(NH2)-COOH (II) in which R2 is a hydrogen atom or an alkyl radical containing 1 to 4 carbon atoms, in a molar ration of(a) to (b) of from about 1:1 to about 1:2, respectively, and further containing (c) a solubilizer selected from the group consisting of benzyl alcohol, 2-phenoxyethanol, 1-phenoxypropanol, and mixtures thereof.
Patent DK-0617031-T3 (DK)
Inventor: BARTROLI JAVIER
IPC: A61P31/04
Filed: 1994-03-15
Granted: 1999-06-14
Abstract: The present invention relates to new orally active azole derivatives with antifungal activity of formula I <CHEM> wherein: X is CH or N; Ar represents phenyl substituted with halogen and/or trifluoromethyl; Z is -C(=O)- or -SO2-; R1 is CN, CO2H, CO2R7, CONR8R9 or CH2Y and then R3 is hydrogen, or R1 together with R3 forms a ring of formula I' <CHEM> wherein B is O, hydroxy or hydrogen; R4 is C1-4 alkyl; R5, R6, R8 and R9 are hydrogen or C1-4 alkyl; Y is -OH, -OR7, -OC(=O)R7, -NR8R9,-NHC(=O)OR7; R7 is C1-C4-alkyl, phenyl-C1-C4-alkyl or optionally substituted phenyl; when Z is -C(=O)-, R2 is optionally susbtituted phenyl, naphtyl, or an heterocycle; when Z is -SO2-, R2 is C1-4 alkyl, phenyl-C1-4-alkyl or optionally susbtituted phenyl.
Patent DK-0624641-T3 (DK)
Inventor: GELFAND DAVID H
IPC: C12R1/19
Filed: 1994-05-02
Granted: 2001-04-17
Abstract: The invention relates to purified thermostable DNA polymerases from Pyrodictium species, such as Pyrodictium occultum or Pyrodictium abyssi, which polymerases catalyze the combination of nucleoside triphosphates to form a nucleic acid strand complementary to a nucleic acid template strand. The preferred polymerases are characterized by their ability to function efficiently in a polymerase chain reaction, wherein said reaction includes repeated exposure to a denaturation temperature of about 100 DEG C. Most preferably the polymerases display 5'->3' exonuclease activity, i.e. are proofreading enzymes. The invention also provides DNAs encoding the DNA polymerase activity of the said Pyrodictium species, which DNAs can be used to construct recombinant vectors and transformed host cells for production of polypeptides having said activity. The invention also relates to the preparation of said thermostable DNA polymerases, to the use of said polymerases to amplify nucleic acids as well as to kits comprising a polymerase of the present invention.
Patent DK-0674495-T3 (DK)
Inventor: SKIBA JEFFRY B
IPC: A61F2/30
Filed: 1993-12-15
Granted: 2002-03-11
Abstract: A joint implant is presented having an elongated cylindrical member with an annular spacer which accommodates the diameter of the cylindrical member by fitting loosely over the cylindrical member. The ends of the elongated cylindrical member are designed for insertion into the intramedullary canals of adjacent bones while the annular spacer is designed to cushion the joint and maintain proper spacing between the bones.
Patent DK-0656049-T3 (DK)
Inventor: JESCHKE RAINER
IPC: C11D3/10
Filed: 1993-08-13
Granted: 1998-07-27
Abstract: PCT No. PCT/EP93/02159 Sec. 371 Date Feb. 22, 1995 Sec. 102(e) Date Feb. 22, 1995 PCT Filed Aug. 13, 1993 PCT Pub. No. WO94/04648 PCT Pub. Date Mar. 3, 1994A pourable, aqueous cleaning composition containing: (a) at least 50% by weight of sodium bicarbonate having a mean particle size of about 200+/-100  mu m; (b) from about 2 to 30% by weight of a surfactant mixture selected from alkyl sulfates, alkyl ether sulfates, narrow-range alkyl polyglycol ethers and soap; and (c) the remainder, water.
Patent DK-0679082-T3 (DK)
Inventor: HOLTON ROBERT A
IPC: C07D407/12
Filed: 1994-01-14
Granted: 2003-02-17
Abstract: Taxane derivatives substituted on the C10 position with novel substituents are disclosed. The novel compounds have utility as antileukemia and antitumor agents.
Patent DK-0705244-T3 (DK)
Inventor: SANDROCK KLAUS
IPC: C07C323/59
Filed: 1994-06-24
Granted: 1999-07-19
Abstract: PCT No. PCT/DE94/00726 Sec. 371 Date Dec. 5, 1995 Sec. 102(e) Date Dec. 5, 1995 PCT Filed Jun. 24, 1994 PCT Pub. No. WO95/00477 PCT Pub. Date Jan. 5, 1995The invention relates to novel nitrates containing a disulphide group, and to processes for their preparation. The compounds can be used for the therapy of disorders of the cardiovascular system.
Patent DK-0695759-T3 (DK)
Inventor: PETTIT GEORGE R
IPC: A61K38/00
Filed: 1995-07-21
Granted: 2002-07-29
Abstract: Herein disclosed are several pentapeptide methyl ester derivatives of dolastatin 10, using both naturally occurring and modified amino acids. The selected modified amino acids are constituents of dolastatin 10 which is a structurally distinct peptide with excellent in vitro and in vivo antineoplastic activity. The structures of these compounds are as shown below: <MATH>       10a) R1 = i-Pr ; R = -NH(Me)2 ; R2 = -CH2CH2CH2NH-cbz   10b) R1 = i-Pr ; R = -NH (Me)2 ; <CHEM>     11a) R1 = - (CH2)4NH-cbz ; R = -NH (cbz) ; <CHEM>     11b) <CHEM>  R = -NH(cbz) ; R2 = -CH2CH2CH2NH-cbz   11c) <CHEM> R = -NH(cbz) ; R2 = -CH2-S-Me m
Patent DK-0691393-T3 (DK)
Inventor: JOCHEM GERARD
IPC: C10L3/00
Filed: 1995-06-30
Granted: 2000-10-16
Abstract: Drying gaseous or liq. mixts. comprises passing the mixt. through an adsorber. The adsorption equilibrium zone of water in the adsorber comprises an up-stream zone of alumina and a down-stream zone comprising a molecular sieve.
Patent DK-0746327-T3 (DK)
Inventor: BENJAMIN NIGEL
IPC: A61P31/04
Filed: 1995-02-17
Granted: 2004-05-10
Abstract: The invention relates to the use of acidified nitrite as an antimicrobial agent and describes a dosage form for use in the treatment of bacterial, viral or fungal conditions. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. Amongst the many potential applications for the invention, the inventive composition has been shown to be particularly effective as an animal feed supplement, and as an agent for sterilising objects. Compositions and methods of use for these applications are described.
Patent DK-0783297-T3 (DK)
Inventor: CHOI LEWIS S L
IPC: A61K47/48
Filed: 1995-10-02
Granted: 1999-10-11
Abstract: The present invention provides a novel class of polyethylene glycol modified ceramide lipids. The lipids can be used to form liposomes optionally containing various biological agents or drugs, such as anti-cancer agents. In addition, methods of use for the liposomes are provided.
Patent DK-0783366-T3 (DK)
Inventor: BURTON SIMON C
IPC: B01J20/32
Filed: 1995-09-20
Granted: 2004-12-20
Abstract: Disclosed are rationally designed mixed mode resins which are useful in recovering a target compound from an aqueous solution and methods for use of such resins. The resins described herein have a hydrophobic character at the pH of binding of the target compound and a hydrophilic and/or electrostatic character at the pH of desorption of the target compound from the resin and are specifically designed to bind the target compound from an aqueous solution at both a low and high ionic strength.
Patent DK-0824483-T3 (DK)
Inventor: DAVIES DAVID EIFION
IPC: B05B11/00
Filed: 1996-03-21
Granted: 2000-10-02
Abstract: PCT No. PCT/EP96/01558 Sec. 371 Date Jan. 28, 1998 Sec. 102(e) Date Jan. 28, 1998 PCT Filed Mar. 21, 1996 PCT Pub. No. WO96/32343 PCT Pub. Date Oct. 17, 1996A pump dispenser suitable for striped toothpaste, comprising a pump head [1] and a replaceable reservoir [2] for the toothpaste, in which the toothpaste is packed in radially disposed segments, and the reservoir is locked against rotation relative to the pump head.
Patent DK-0832152-T3 (DK)
Inventor: HOUBEN JOCHEN
IPC: D06M15/263
Filed: 1996-06-10
Granted: 2002-08-05
Abstract: PCT No. PCT/EP96/02503 Sec. 371 Date Dec. 16, 1997 Sec. 102(e) Date Dec. 16, 1997 PCT Filed Jun. 10, 1996 PCT Pub. No. WO97/00280 PCT Pub. Date Jan. 3, 1997The present invention relates to a printable formulation of a superabsorbent polymer and to the application forms of the product, for example, for cable insulation and for the production of nonwovens. The formulation is preferably supplied in the form of a two-component package consisting of precrosslinked superabsorber and reactive cross-linking agent and mixed in-situ to form the product. The obtained printing paste is printed on a substrate, for example, a nonwoven. For cable insulation purposes, the product is subsequently incorporated into the cable in a conventional manner.
Patent DK-0832108-T3 (DK)
Inventor: CHU ALEXANDER H T
IPC: C07K1/34
Filed: 1996-06-07
Granted: 2000-09-25
Abstract: A novel process for recovering water insoluble compounds from a fermentation broth includes sequential steps of concentrating, solubilizing and diafiltering the compound of interest, all through a single closed recirculation system to recover the compound for further downstream purification.
Patent DK-0848650-T3 (DK)
Inventor: DE WITT MARK W
IPC: B60S1/52
Filed: 1996-07-29
Granted: 2004-02-09
Abstract: Liquid and air outlet nozzle assemblies are capable of mounting on a vehicle adjacent the headlights and are positioned such that liquid and air jets from the nozzles intersect prior to engaging the headlight to form a spray mixture that cleans the headlight. The nozzle assemblies are associated with a control valve capable of connection in a pressurized air system on the vehicle and in the pressurized washer system for the windshield wipers and also capable of automatically directing liquid from the vehicle washer system and pressurized air on the vehicle to the liquid and air nozzles to form a headlight cleaning function upon manual activation of the pressurized windshield washer system of the vehicle. An embodiment of the nozzle assembly has an extension and retraction piston for extending nozzle openings toward the headlight in operation condition of the assembly.
Patent DK-0853480-T3 (DK)
Inventor: KEMPEN HERMAN
IPC: A61K31/00
Filed: 1996-08-30
Granted: 2003-05-05
Abstract: PCT No. PCT/EP96/03814 Sec. 371 Date Feb. 23, 1998 Sec. 102(e) Date Feb. 23, 1998 PCT Filed Aug. 30, 1996 PCT Pub. No. WO97/09048 PCT Pub. Date Mar. 13, 19979-methyl-4-phenyl-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine for the treatment and prevention of illnesses which are caused by low plasma apolipoprotein A-I levels as coronary coronary disease.
Patent DK-0876504-T3 (DK)
Inventor: WILSON STUART MARK
IPC: C12Q1/04
Filed: 1996-12-16
Granted: 2003-03-03
Abstract: PCT No. PCT/GB96/03097 Sec. 371 Date Jul. 27, 1998 Sec. 102(e) Date Jul. 27, 1998 PCT Filed Dec. 16, 1996 PCT Pub. No. WO97/22713 PCT Pub. Date Jun. 26, 1997The present invention relates to a method for enhancing the time of response of an assay for a first bacterium, wherein: a) the first bacterium is exposed to infection by phage particles to which the first bacterium is permissive; b) the infected bacterium is treated to inactivate exogenous phage particles; c) the treated bacterium is cultivated in the presence of a second bacterium which is permissive to infection by the phage or its replicand and which has a doubling rate greater than the effective doubling rate of the first bacterium; and d) assessing the extent of plaque formation and/or of second bacterium growth in the cultivated second bacterium cells. The method can be used to assess the presence of first bacterium in a sample, notably where the first bacterium is a slow growing bacterium, such as Mycobacterium tuberculosis, where the method enables an operator to detect the presence of low amounts of the bacterium in sample within days instead of weeks as required by conventional cultivation techniques. The invention can also be used to assess the effect of a drug or other treatment on a bacterium or on a virus. The invention also provides a diagnostic kit for use in the method of the invention.