Patent SG-11201811760V-A (SG)
Title: Oral dosage form with drug composition, barrier layer and drug layer
Inventor: YUM SU IL
IPC: A61K31/4458
Filed: 2017-07-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/009566 Al 11 January 2018 (11.01.2018) W I PO I PCT (51) International Patent Classification: (71) Applicant: DURECT CORPORATION [US/US]; 10260 A61K 9/48 (2006.01) A61K 31/4458 (2006.01) Bubb Road, Cupertino, CA 95014 (US). A61K 9/52 (2006.01) A61K 47/26 (2006.01) (72) Inventors: YUM, Su IL; 1021 Runnymead Court, Los Al- A61K 9/56 (2006.01) A61K 47/32 (2006.01) tos, CA 94024 (US). CHAO, Wendy; 1058 S. Blaney Av- A61K 47/14 (2017.01) A61K 47/38 (2006.01) enue, San Jose, CA 95129 (US). SU, Huey-Ching; 1138 (21) International Application Number: Strada Almaden, San Jose, CA 95120 (US). CHEN, Yen- PCT/US2017/040750 Fei; 45.-5, No. 112, Taiping Rd ND, 404 Taichung City (22) International Filing Date: (TW). CHIANG, Chin-Chih; 2700 Vanderhoof Drive, 05 July 2017 (05.07.2017) West Covina, CA 91791 (US). (25) Filing Language: English (74) Agent: RUBIN, Michael, B.; Bozicevic, Field & Francis LLP, 201 Redwood Shores Parkway, Suite 200, Redwood (26) Publication Language: English City, CA 94065 (US). (30) Priority Data: (81) Designated States (unless otherwise indicated, for every 62/359,111 06 July 2016 (06.07.2016) US kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (54) Title: ORAL 12 00 7 ,. . . 0. DOSAGE FORM WITH DRUG 1 - . I I A f PK Profiles COMPOSITION, for FIGURE Formulations A BARRIER LAYER 12 -E AND DRUG LAYER in followed the dosage of the 18 pharmacologically and reduced a con- by drug 8.00 1 6.00 - EE 4.00 1 2.00 0.00 I : release in the includes agent. Related methods of making and I\"' release i -- - The present disclosure provides manner. For fed state. Such dosage forms phase a drug composition and a drug layer 9 find use in a E (Cpincert ) —A dosage for a pharmacologically administering disclosure includes dosage forms portion example forms of the the a variety Time designed in the active barrier disclosed 9 10 (hr) to treatment of conditions where layer, deliver agent, dosage 11 of with ADHD, pain a barrier wherein the forms 12 active are 13 pharmaceutical adequate time a rapid layer covering or drug layer 14 onset also provided. of anxiety. 8 Coriperta (APIs) cases, instance, the present for the active agent, including covering at least 15 includes 16 17 ingredients of onset of action action is desired In some at least a portion the Il (57) trolled in lag times ON an extended © form 0 --.... composition, GC active 1-1 0 ei o [Continued on next page] WO 2018/009566 Al MIDEDIMOMMIDIREEMOOVIRIHRIEHRUDIMIE DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))