baber/WOPTO huggingface dataset:
Patent CA-2692370-A1 (CA)
Inventor: BRAMBILLA GAETANO
IPC: B05B1/00
Filed: 2008-06-27
Abstract: A metered dose inhaler actuator for pressurised aerosol containing a formulation of at least one medicament in a liquefied propellant gas.  The actuator (2) comprises - a nozzle block (5) having a bore (11) to receive a valve stem (7) - a sump (8) in connection with a bore (11), wherein the propellant formulation expands upon actuation of the inhaler, - a nozzle channel (6), exiting from the sump (8) and aligned with a mouthpiece (4) wherein the sump (8) is characterised for having an internal volume comprised between (12 and 2 mm3) to avoid deposits of the medicament during the delivery into the chamber and/or into the nozzle channel which could cause a reduction in the delivered dose and an increase in the occurrence of the clogging of the inhaler. The actuator of the invention is particularly useful in the administration of pressurised metered dose inhaler formulations, in solution and/or in suspension, wherein the concentration of the active ingredient/s of the formulation is/are particularly high and in particular suitable to administer at least 100 µg/dose, preferably at least 200 µg/dose, even more preferably at least 400 µg/dose.
Patent CA-2692925-A1 (CA)
Inventor: ADAMS HORST
IPC: B22F3/20
Filed: 2008-07-04
Abstract: In a method for producing a profile by extruding powdered metal and/or powdered metal alloys, a bulk powder material is heated to an extrusion temperature below the melting temperature of the powder and pressed under pressure through an opening of a die to form the profile. At least one metal or a metal alloy of the powder is a reactive metal spontaneously forming a natural oxide protective layer on a free surface and/or the powder contains fibre-like particles distributed homogeneously in the bulk powder material and absorbing microwave radiation.  The bulk powder material is heated by microwave irradiation to extrusion temperature. The method achieves rapid and uniform heating in all regions of the bulk powder material.
Patent CA-2693553-A1 (CA)
Inventor: NEUFELD GERA
IPC: A61K31/713
Filed: 2008-07-15
Abstract: The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA  targeting LOXL2.
Patent CA-2693630-A1 (CA)
Inventor: WHITELAW ELLA
IPC: A23L5/10
Filed: 2007-07-13
Abstract: The present invention relates to rice oil, rice bran and rice seeds which have altered levels of oleic acid, palmitic acid and/or linoleic acid. The present invention also provides methods for genetically modifying rice plants such that rice oil, rice bran and rice seeds produced therefrom have altered levels of oleic acid, palmitic acid and/or linoleic acid. Specifically this is achieved through modulation of Fad2 and/or FatB expression.
Patent CA-2694235-A1 (CA)
Title: Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition
Inventor: DUEWELHENKE NICOLE
IPC: A61K38/08
Filed: 2008-07-23
Abstract: The invention relates to the use of a pharmaceutical composition for the local treatment or prevention of a tissue infection at an infection site, the pharmaceutical composition comprising at least two different antibiotics of group A or pharmaceutically acceptable derivatives thereof, or an antibiotic of group A and at least one antibiotic of group B or pharmaceutically acceptable derivatives thereof. Group A comprises primarily intracellular active antibiotics working as inhibitor of bacterial RNA  polymerase; as inhibitor of gyrase; or as inhibitor of bacterial protein synthesis. Group B  comprises primarily extracellular active antibiotics working as inhibitor of bacterial cell wall synthesis; or inhibitor of bacterial protein synthesis; or by direct destabilisation or rupture of the bacterial cell wall.   The invention further relates to a pharmaceutical composition for treatment of extracellular and/or intracellular microbial infected cells and/or for the prevention of microbial cell infections comprising at least one antibiotic acting as an inhibitor of bacterial RNA polymerase and/or at least one antibiotic affecting the bacterial cell wall or its synthesis, and a substrate carrying a pharmaceutical composition.   The invention also relates to the use of a combination of at least one antibiotic acting as an inhibitor of bacterial RNA polymerase and at least one antibiotic affecting the bacterial cell wall or its synthesis as anti-adhesive against microorganisms on surfaces.
Patent CA-2695031-A1 (CA)
Inventor: KUMAR PRABHAT
IPC: C07D413/06
Filed: 2008-06-24
Abstract: The present invention relates to novel compounds of formula (I) or (II), their pharmaceutically acceptable salts and their hydrates, solvates, stereoisomers, conformers, tautomers, polymorphs and prodrugs and also pharmaceutically acceptable compositions containing them Wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification. The compounds of the present invention are HSP inducers and by virtue of this effect, useful for the treatment of various diseases accompanying pathological stress.  The present invention also relates to a process for the preparation of the said novel compounds. The invention also relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.
Patent CA-2697254-A1 (CA)
Inventor: BRIARD EMMANUELLE
IPC: A61K31/382
Filed: 2008-08-22
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
Patent CA-2698535-A1 (CA)
Title: Nutritional supplement formulations for inclusion in foods and fortified foods comprising such supplements
Inventor: HITZ HANS
IPC: A23L33/155
Filed: 2008-09-15
Abstract: The present invention relates to formulations adapted from the original AREDS  formula that are suitable for introduction into a measured amount or volume of a food as well as to foods containing these formulations. These fortified foods are expected to provide patients afflicted with or at risk for developing macular degeneration or other age-related deficiencies with alternative and more palatable sources of the ingredients of the original AREDS formula than those currently available in the market.
Patent CA-2698615-A1 (CA)
Inventor: HARRIS JOEL S
IPC: B26B27/00
Filed: 2010-04-06
Abstract: A motorized apparatus to simultaneously excise, retrieve, temporarily store and transport a sample of material has a hollow clamshell casing with a blended contoured grip for the fingers, a horizontal extension to eliminate slippage when held in a user's hand, and a flange bottom portion from which a removable cutting tool threaded to a drive shaft extends downwards. Within the clamshell casing an electric motor is mounted which drives, via gears, a drive shaft which rotates a cutting tool threaded to the distal end of the drive shaft. The end of the cutting tool, distal from the clamshell casing, forms a cutting edge circumscribing a circular region. An ejection rod slides reciprocally within the cutting tool between a stowed position and an expulsion position.  Users core a sample from the source material by engaging contact between the cutting edge of the cutting tool and the surface of the source material, applying pressure against the surface of the source material while simultaneously activating the motor to rotate the cutting tool. The cutting region of the cutting tool passes through the source material contacting the support surface below the source material which urges the cored sample into the lumen of the cutting tool. The sample may be stored in the lumen or transported. Activation of the ejection rod moves from the stowed position towards the expulsion position displacing the temporarily stored sample from the lumen space in the cutting tool into the appropriate collection receptacle or onto a desired surface.
Patent CA-2700706-A1 (CA)
Inventor: TERASHIMA HIDETOSHI
IPC: H05B6/36
Filed: 2008-09-26
Abstract: In an induction heating coil for use in continuous heating of a steel plate while passing the steel plate, the conventional induction heating coil has an insulating structure which has been selected while taking mainly into consideration heat resistance and insulating properties of an insulator per se. In the conventional induction heating coil, a lowering in insulating properties caused by the entry of metallic fine particles (for example, zinc fume) in an atmosphere cannot be prevented. This invention provides an insulating structure for an induction heating coil, which can prevent the entry of metallic fine particles such as zinc fume, does not undergoes a lowering in strength even under a high-temperature environment, and can prolong the service life of the induction coil. Specifically, the surface of an induction heating coil is covered with a ceramic cloth of ceramic long fibers formed of an alumina-silica material and free from boron. A heat resistant insulating layer formed of a ceramic surface hardening material containing fine particles of an alumina or an alumina-silica material and ceramic short fibers formed of an alumina-silica material is additionally provided on the surface of the ceramic cloth.
Patent CA-2703333-A1 (CA)
Title: Non-invasive method to perform skin inflammatory disease pharmaco-genomic studies and diagnosis method thereof
Inventor: AUBERT JEROME
IPC: C12Q1/68
Filed: 2008-10-27
Abstract: The present invention relates to non-invasive method to perform skin inflammatory disease pharmaco-genomic studies and diagnosis methods thereof. Invention also concerns discriminating biomarkers and genes and in vitro diagnostic methods using said biomarkers.
Patent CA-2704225-A1 (CA)
Inventor: PIAO XIANZHEN
IPC: A45D40/26
Filed: 2008-10-16
Abstract: One embodiment of a head-switchable brush, comprises brush heads with ferrules, and a brush handle. The ferrule has the head at one end and the handle at the other end. Heads can be mounted on two different locations on the handle. There is a piece of magnet attached to the brush handle and ferrule respectively where the two parts connect. The brush head can be switched and assembled with the handle easily whenever needed. The ferrule can be kept firmly on the handle by the action of the magnet inside. The head- switchable function of this brush kit can greatly enlarge the scope for use of the brush and also avoid the waste of material since this brush kit has one handle only but with various brush heads.
Patent CA-2704846-A1 (CA)
Inventor: HIRST LAWRENCE WILLIAM
IPC: B01D35/02
Filed: 2008-11-05
Abstract: An apparatus for recovery of suspended biological material from a suspension solution, the apparatus including a suspension solution container to temporarily hold the suspension solution, extraction means to apply extractive force to the container to extract the suspension solution temporarily held therein and the filter means sized to separate the suspended biological material from the suspension solution.
Patent CA-2705476-A1 (CA)
Title: Method and apparatus for state/mode transitioning
Inventor: YOUNG GORDON PETER
IPC: H04W8/18
Filed: 2008-11-13
Abstract: A method and network element to control use of a transition indication message by a user equipment, the method including an inhibit transition indication in a configuration message; and sending the configuration message with the inhibit transition indication to the user equipment. Also, a method and user equipment for sending a transition indication, the method setting a timer according to an inhibit transition indication received from a network element; detecting that a data transfer is complete; and sending the transition indication upon detecting that the timer is not running.
Patent CA-2706529-A1 (CA)
Title: Anti-mesothelin antibodies and uses therefor
Inventor: KAHNERT ANTJE
IPC: C07K16/30
Filed: 2008-11-19
Abstract: The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
Patent CA-2707615-A1 (CA)
Inventor: DIETZ JOCHEN
IPC: C07D407/14
Filed: 2008-12-12
Abstract: The invention relates to the triazolylmethyloxiranes of formula (I), wherein variables A, B and D have the meanings as defined in the description and the claims.
Patent CA-2707907-A1 (CA)
Inventor: HALLAND ROBIN
IPC: E04H7/22
Filed: 2010-07-02
Abstract: A roof ventilation system for efficiently allowing air to flow through the peak of a grain bin year round. The roof ventilation system generally includes a frame extending from the upper opening, wherein the frame defines a passageway extending through an interior of the frame adapted to communicate air flow between an interior of the grain bin and ambient air. A shell at least partially surrounding the frame to at least partially seal the interior of the frame.  A screen is interconnected between the frame and the shell, wherein the screen includes a plurality of outlets extending therethrough in communication with the passageway. A heating element is in communication with the screen, wherein the heating element dissipates heat to the screen to prevent ice buildup upon the screen.
Patent CA-2708037-A1 (CA)
Inventor: HEAL JONATHAN RICHARD
IPC: G01N33/566
Filed: 2008-12-08
Abstract: A method of producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to its parent GPCR, the method comprising: a) providing one or more mutants of a first parent GPCR with increased stability relative to the first parent GPCR b) identifying in a structural membrane protein model the structural motif or motifs in which the one or more mutants have at least one different amino acid residue compared to the first parent GPCR, and c) making one or more mutations in the amino acid sequence that defines a corresponding structural motif or motifs in a second parent GPCR, to provide one or more mutants of a second parent GPCR with increased stability relative to the second parent GPCR. Mutants of ß-adrenergic receptor, adenosine receptor and neurotensin receptor are also disclosed.
Patent CA-2709709-A1 (CA)
Inventor: BUNICK FRANK J
IPC: A61K31/44
Filed: 2008-12-17
Abstract: The present invention features a method of manufacturing a tablet containing a pharmaceutically active agent by the steps of. (a) adding a powder containing a pharmaceutically-acceptable carrier to a die cavity; (b) injecting a liquid drug com-position containing the pharmaceutically active agent into the die cavity such that the liquid drug composition contacts the pow-der;  (c) compressing the combination of the powder and the liquid drug composition within the die cavity to form the tablet, and (d) removing the tablet from the die cavity.
Patent CA-2711555-A1 (CA)
Title: Method for conditioning radioactive ion exchange resins
Inventor: GASSEN RAINER
IPC: G21F9/28
Filed: 2009-01-15
Abstract: The invention relates to a method for conditioning a contaminated ion exchange resin, by mixing the same with water and at least partly breaking up the same into water--soluble components by means of an oxidising agent added to the water, wherein the resulting aqueous solution is immobilised with a binder, optionally after concentration by evaporation of water.
Patent CA-2711928-A1 (CA)
Inventor: SHINODA TOMOYUKI
IPC: D04H3/04
Filed: 2009-01-08
Abstract: Provided are: a curved reinforcing fiber substrate (1) characterized by having a curved planar shape and by comprising reinforcing fiber yarns (2) arranged parallel with a direction along a circumferential direction (3) of the curved shape and auxiliary weft yarns (4) arranged in directions crossing a plurality of the reinforcing fiber yarns (2) each arranged in one direction of the circumferential direction (3); a curved reinforcing-fiber layered product using the substrate; a preform; a reinforced composite material; and processes for producing those. These can be provided as: a reinforcing fiber substrate curved along the longitudinal direction and arranged with reinforcing fibers along the curved shape in a desirable formation; a curved reinforcing-fiber layered product layered with at least one layer of the reinforcing fiber substrate and a process for producing the layered product efficiently in a short time; a preform using the layered product and a process for forming the preform efficiently; and a long-extended curved fiber-reinforced composite material and a process for producing the same.
Patent CA-2712390-A1 (CA)
Inventor: VAN DER VAART RICK
IPC: B01D45/14
Filed: 2009-01-28
Abstract: Apparatus for the separation of gas and solid and/or liquid contaminants, comprising a housing with a gas inlet for contaminated gas at one end of the vessel, a separating body, a gas outlet for purified gas at the opposite end of the housing and a contaminants outlet downstream of the separating body, wherein the separating body comprises a plurality of ducts over a part of the length of the axis of the housing, which ducts have been mounted on a central axis of rotation, in which apparatus the separating body has been composed of a plurality of perforated discs wherein the perforations of the discs form the ducts.
Patent CA-2713643-A1 (CA)
Inventor: SWAB JOHN H
IPC: B05B15/02
Filed: 2010-08-24
Abstract: A foam dispensing assembly comprises a dispensing head and a manifold assembly. The manifold assembly includes a purge portion for supplying a gas and a cleansing fluid to the dispensing head, a first supply portion for supplying a first fluid to the dispensing head and a second supply portion for supplying a second fluid to the dispensing head. Each of the purge portion, the first supply portion and the second supply portion include a plurality of check valves and flow control valves for controlling the flow of the first fluid, the second fluid, the gas and the cleansing fluid through the manifold assembly. Each of the first supply portion and the second supply portion include an integral flow control device for regulating a fluid flow rate to the dispensing head, and a thermometer for sensing the temperature of the first fluid and the second fluid respectively.
Patent CA-2717428-A1 (CA)
Title: Device for injecting a solid
Inventor: SCHMALZ CHRISTIAN
IPC: A61M5/178
Filed: 2010-10-13
Abstract: A device (100) for injecting a solid (500) into a human or animal body comprises a syringe body (300) with a first tubular interior for receiving the solid (500), a retaining device for retaining the solid (500) in the syringe body (300), and a needle (200) with a second tubular interior. The needle (200) is connected to the syringe body (300) such that the second tubular interior of the needle (200) communicates with the first tubular interior of the syringe body (300). The device further comprises a ram (400), which can be driven through the first interior into the second interior. The ram (400) can cooperate directly with the retaining device, such that the retaining device can be deactivated by means of the ram (400).
Patent CA-2718319-A1 (CA)
Inventor: HAMILTON CHARLES W
IPC: C01B3/02
Filed: 2009-04-02
Abstract: Hydrogen ("H2") is produced when ammonia borane reacts with a catalyst complex of the formula LnM-X wherein M is a base metal such as iron, X is an anionic nitrogen-or phosphorus-based ligand or hydride, and L is a neutral ancillary ligand that is a neutral monodentate or polydentate ligand.
Patent CA-2718374-A1 (CA)
Inventor: DUEPPEN DANIEL G
IPC: C12N15/09
Filed: 2002-12-12
Abstract: A process for purifying a lipid composition having predominantly neutral lipid components having at least one long chain polyunsaturated fatty acid is disclosed.
Patent CA-2721097-A1 (CA)
Inventor: QIU WEIMING
IPC: C08G18/28
Filed: 2009-05-15
Abstract: A polymer having at least one carbamate linkage prepared by: (i) reacting (a) at least one diisocyanate, polyiso-cyanate, or mixture thereof, and (b) at least one fluorinated compound selected from the formula (I): R f (CH2)x [(CF2CF2)y(CH2CH2)z]m (R1)r-XH (I) wherein R f is a perfluoroalkyl group having 1 to about 6 carbon atoms; subscript x is1 to about 6; subscripts y, z and m are each independently 1, 2 or 3, or a mixture thereof; subscript r is 0 or 1; the total number of car-bons in said formula (I) excluding (R1)r-XH ranges from about 8 to about 22; X is -O-, -NR-, -S-, -S(CH2)t O-, or -S(CH2)t NR-;  subscript t is from 1 to about 10; R is H or C1-4 alkyl; R1 is certain divalent radicals; n is 2 to 4; s is 1 to about 50; R2, R3, and R4 are each independently hydrogen or a C1-C6 alkyl group; and (ii) optionally reacting with (c) water, a linking agent, or a mixture thereof.
Patent CA-2721127-A1 (CA)
Inventor: SHEPHERD ROBERT A
IPC: F41G7/00
Filed: 2009-02-02
Abstract: A method for measuring an infrared signature of a moving target includes: tracking the moving target with a tracking system along a path from a start position to an end position, measuring infrared radiation data of the moving target along the path, repositioning the tracking system to the start position, retracing the path to measure the infrared radiation data of the background, and determining the infrared signature of the moving target by comparing the infrared radiation data of the moving object with the infrared radiation data of the background without the moving object.
Patent CA-2723673-A1 (CA)
Inventor: GYSLING DANIEL L
IPC: G01F1/66
Filed: 2009-04-10
Abstract: A damping device for a fluid flow meter mountable on the exterior of a pipe to meter fluid flow traveling within the pipe is provided. The flow meter has at least one ultrasonic sensor operable to transmit ultrasonic signals through a pipe wall in a direction normal to the pipe wall and into a fluid flow disposed within the pipe, which signals create secondary ultrasonic signals circumferentially traveling within the pipe wall at a frequency. The damping device includes a base and a plurality of tines. The base is conformable to an exterior surface of the pipe wall, and has a pipe-side surface and a tine-side surface. The plurality of tines is attached to the base and extends outwardly from the tine-side surface. Each tine is spaced apart from an adjacent tine by a tine-to-tine distance that is less than the wavelength of the secondary ultrasonic signals circumferentially propagating within the pipe wall.
Patent CA-2725732-A1 (CA)
Inventor: IPPOLITO MASSIMO
IPC: F03D5/00
Filed: 2009-05-29
Abstract: An infrastructure for tropospheric aeolian generator is described, which comprises a rotary basement (1), at least one orientable arm (2), at least one ventilation plant (3), at least one system (4) for supporting at least one wing (7), and a driving system (5) of control cables (6) of the wing (7).
Patent CA-2729662-A1 (CA)
Title: Essence aviation pour moteurs a pistons d'aeronefs, son procede de preparation
Inventor: DEMOMENT PASCALE
IPC: C10L1/06
Filed: 2009-06-29
Abstract: La présente invention a pour objet une composition d'essence aviation sans plomb et sans composé oxygéné répondant aux spécifications de la norme ASTM comprenant de l'isopentane, de l' isooctane, des (alkyl)aromatiques. La composition d'essence aviation selon l'invention peut être obtenue de manière simple et économique à partir de mélange de bases hydrocarbonées usuellement disponibles en raffinerie.