Patent GB-474614-A (GB)
Title: Method of producing therapeutically and disinfectantly active substances
IPC: A61L2/238
Filed: 1936-05-02
Abstract: Substances containing gold and silver having therapeutic, disinfectant and sterilizing properties are produced by reacting compounds yielding gold and silver ions, in aqueous or other suitable liquid medium, in the presence of alkaline substances with compounds of multivalent metals, a compound of a metal in a lower valency, present as a cation, being employed.  Suitable metal compounds are manganous, cobaltous, nickelous, ferrous and cerous salts.  The silver salt of chlorauric acid may be used as a compound supplying both silver and gold ions.  The alkaline substance may consist of alkalies, alkali carbonates, organic bases, or the oxides, hydroxides or alkaline salts of the multivalent metallic compound used in the reaction.  The product comprises finely divided metallic gold and silver and the higher oxide or hydroxide of the multivalent metal used.  The reaction may be carried out in the presence of protective colloids, e.g. albuminous bodies, vegetable mucilages, lecithin, whereby colloidal solutions suitable for the treatment of various diseases are obtained.  In an example, a gelatin solution is admixed with a solution of silver and manganese nitrates, and a solution of chlorauric acid is then added with stirring.  The resultant colloidal solution of the silver salt of chlorauric acid is rendered alkaline with caustic soda solution.  The solution is then dialyzed for several days in parchment containers to remove electrolytes.  In another example, chlorauric acid solution is added to a solution of manganese and silver nitrates.  The silver salt of chlorauric acid precipitates.  Excess caustic soda solution is then added and the precipitate filtered, washed and dried.  The Specification as open to inspection under Sect. 91 comprises also the precipitation of gold solutions only.  This subject-matter does not appear in the Specification as accepted.ALSO:Substances containing gold and silver having therapeutic, disinfectant and sterilizing properties are produced by reacting compounds yielding gold and silver ions, in aqueous or other suitable liquid medium, in the presence of alkaline substances with compounds of multivalent metals, a compound of a metal in a lower valency, present as a cation, being employed. Suitable metal compounds are manganous, cobaltous, nickelous, ferrous and cerous salts.  The silver salt of chlorauric acid may be used as a compound supplying both silver and gold ions.  The alkaline substance may consist of alkalies, alkali carbonates organic bases, or the oxides, hydroxides or alkaline salts of the multivalent metallic compound used in the reaction.  The product comprises finely divided metallic gold and silver, and the higher oxide or hydroxide of the multivalent metal used.  The precipitated subsubstance may be deposited directly on carrier material, e.g. surgical dressings, textile fibres, cotton, fabrics, animal charcoal, silica gels, bole and other pulverulent materials.  The carrier material may supply the hydroxyl ions, for which purpose it may be of itself alkaline, e.g. alkaline earth carbonates, magnesium or zinc oxide, or it may be pretreated with alkaline substances.  The reaction may be carried out in the presence of protective colloids, e.g. albuminous bodies, vegetable mucilages, lecithin, whereby colloidal solutions suitable for the treatment of various diseases are obtained.  In an example, a gelatin solution is admixed with a solution of silver and manganese nitrates, and a solution of chlorauric acid is then added with stirring.  The resultant colloidal solution of the silver salt of chlorauric acid is rendered alkaline with caustic soda solution.  The solution is then dialyzed for several days in parchment containers to remove electrolytes.  In other examples: (1) chlorauric acid solution is added to a solution of manganese and silver nitrates.  The silver salt of chlorauric acid precipitates.  Excess caustic soda solution is then added, and the precipitate filtered, washed and dried; (2) gauze is dipped in a solution of chlorauric acid and manganese nitrate, squeezed out, immersed in a solution of silver and manganese nitrates, expressed, introduced into caustic soda solution, washed and dried.  The Specification as open to inspection under Sect. 91 comprises also the precipitation of gold solutions only, and the impregnation of the carrier materials with the precipitate.  The gold preparations are stated to activate other oligodynamically active substances, for example, argentiferous substances.  In examples: (1) a solution of chlorauric acid and manganese nitrate is admixed with caustic soda solution; a precipitate 2Au.3MnO2 results; (2) a solution of chlorauric acid and cerous nitrate is admixed with caustic potash solution; a precipitate Au.3CeO results; (3) a suspension of precipitated calcium carbonate in a solution of gold chloride and manganese nitrate is boiled; (4) gauze is dipped into a solution of chlorauric acid and manganese nitrate, expressed, and introduced into caustic soda solution; (5) gauze is dipped into a solution of chlorauric acid and manganese nitrate, expressed, introduced into caustic soda solution, washed, immersed in a solution of manganese nitrate and silver nitrate, expressed, bathed in the caustic soda solution, washed and dried; (6) gauze is treated as at (5) above, except that precipitation of silver precedes that of the gold. This subject-matter does not appear in the Specification as accepted.