baber/WOPTO huggingface dataset:
Patent WO-2015183085-A1 (WO)
Inventor: VERHOEF DANIËL
IPC: C12N9/64
Filed: 2015-05-26
Abstract: The present invention relates to recombinant FXa polypeptides that can be used as antidotes to completely or partially reverse an anti-coagulant effect of a coagulation inhibitor in a subject, preferably a direct factor Xa inhibitor. Disclosed herein are recombinant factor Xa proteins and a method of completely or partially reversing an anti-coagulant effect of a coagulation inhibitor in a subject.
Patent WO-2019035712-A1 (WO)
Title: Carrier for holding poultry carcasses
Inventor: VAN BUSSEL GERARDUS JOHANNES CATHARINA
IPC: A22C21/00
Filed: 2018-08-13
Abstract: The present invention relates to a carrier for holding poultry carcasses, comprising a frame part, for attaching the carrier to a processing line; a hook part, fixed to the frame part; and a support part, rotatably connected to the frame part, wherein the support part is movably between an unloaded position, in which a poultry carcass can be loaded on the carrier, between the hook part and the support part; and a loaded position, in which the poultry carcass is being held by the carrier, between the hook part and the support part. The poultry carcass may for instance be a breast cap, including breast fillets and a breast bone. The invention also relates to a method of providing poultry carcasses on such carrier.
Patent WO-2019160418-A1 (WO)
Title: Endothermic salt regeneration for cooling and air-conditioning
Inventor: GOETHEER EARL LAWRENCE VINCENT
IPC: F28D20/00
Filed: 2019-02-18
Abstract: The invention is directed to a method and a system for regenerating an endothermic salt composition from an aqueous solution thereof, said method comprising a) contacting a switchable-polarity compound with the aqueous solution of the endothermic salt composition to obtain a raffinate phase and an extract phase, wherein the raffinate phase comprises said endothermic salt composition in a higher concentration than said aqueous solution and said extract phase comprises the switchable-polarity compound and water; and b) separating the raffinate phase and the extract phase into a separated raffinate and a separated extract. The endothermic salt can be used in systems for cooling food, milk, medicines and/or air.
Patent WO-2019164397-A1 (WO)
Title: Porous embolization microspheres comprising drugs
Inventor: KOOLE LEVINUS HENDRIK
IPC: A61K31/519
Filed: 2019-02-22
Abstract: The current invention provides a method of forming polymeric microspheres loaded with therapeutic agent, comprising: a. exposing porous polymeric microspheres to an organic solvent comprising a dissolved therapeutic agent thereby creating microspheres loaded with therapeutic agent, b. separating the microspheres loaded with therapeutic agent from the organic solvent, c. washing the microspheres loaded with therapeutic agent with water, and d. drying the washed microspheres. The microspheres are particularly useful in embolization therapy.
Patent WO-2020171711-A1 (WO)
Inventor: GLAS RONALD JOHANNES
IPC: A61K31/05
Filed: 2020-02-21
Abstract: The present invention relates to a pharmaceutical composition comprising a tetrahydrocannabivarin (THCV), wherein the composition further comprises cannabigerol (CBG) or cannabinodiol (CBND) or a mixture thereof, for use in the prevention and treatment of overweight, preferably associated with obesitas. The pharmaceutical composition according to the invention may further comprise the following additional compounds tetrahydrocannabinol (THC), or Cannabigerol (CBG) or Cannabinodiol (CBND) or a combination thereof.
Patent WO-2020242299-A1 (WO)
Title: Protein from peeled tubers
Inventor: SPELBRINK ROBIN ERIC JACOBUS
IPC: A23J3/00
Filed: 2020-05-25
Abstract: The invention provides a method for obtaining a tuber protein isolate, comprising a) peeling at least one tuber, thereby obtaining at least one peeled tuber and a tuber peel composition; b) processing said at least one peeled tuber to obtain an aqueous liquid comprising tuber protein; and c) subjecting said aqueous liquid to a protein isolation step to obtain said tuber protein isolate. It has been found that peeling potatoes prior to protein isolation has several benefits: the isolated crude protein, or a hydrolysate thereof, is more clean, and has a composition enriched in tyrosine, proline, arginine glutamine, glutamate, asparagine and aspartate. The protein composition obtained from the tuber peels on the other hand is enriched in the essential amino acids threonine, leucine, isoleucine, methionine and phenylalanine.
Patent WO-2020246880-A1 (WO)
Title: Insect breeding device
Inventor: JANSEN JACO
IPC: A01K67/033
Filed: 2020-06-03
Abstract: The invention relates to an insect breeding device. The insect breeding device comprising at least one insect cage (101) having a top wall (16A) with a non-curved and flat surface or having a top wall with a concave inner surface (seen from the interior of the insect cage); a bin (120) for holding a cleaning liquid; a first pipe (3) connected to the bin for receiving the cleaning liquid, wherein the pipe is entering the at least one insect cage through a first opening (11); a nozzle (14), coupled to the first pipe, positioned inside the at least one insect cage configured to deliver the cleaning liquid to the interior of the at least one insect cage; and a second pipe (4), coupled to a second opening (12), different from the first opening and located in the bottom wall of the cage and/or located in a side wall of the cage, in the side wall portion where the bottom wall and said side wall intersect, in the at least one insect cage, configured to drain the cleaning liquid and the debris remaining from farming insects in the cage, from the at least one insect cage.
Patent WO-2021034188-A1 (WO)
Title: Pellet press with cooling system and method of manufacturing pellets
Inventor: CLEVEN ARNOLD PETER THEODOOR
IPC: B30B15/26
Filed: 2020-08-12
Abstract: A pellet press comprising a shaft with a longitudinal axis, having at a roller support side an end part supporting a bearing and a rotation member, wherein the shaft is provided with a cooling channel extending along the longitudinal axis, and a cooling duct extending coaxially within the cooling channel, both being closed at the roller support side, the shaft further comprising at least one bearing cooling channel having first and second radial sections extending in a radial direction through the end part, from roller support side and upstream positions of the cooling channel wall, to an outward end position near the bearing, and a third axial section extending in the axial direction, interconnecting the first and second radial sections, and a fluid seal between the outer surface of the cooling duct and the cooling channel wall at an axial position between the first and second radial sections.
Patent WO-2005116682-A1 (WO)
Title: Dispositif destine a la localisation precise d'objets
Inventor: HJELMSTAD JENS FREDRIK
IPC: G01S7/00
Filed: 2005-03-23
Abstract: L'invention concerne un dispositif qui comprend un certain nombre de systèmes de localisation géographique, chaque système de localisation géographique (A, B) comprenant au moins un moyen de détection primaire de direction ou de position (1, 3) qui détermine la direction ou la position d'un objet, un moyen de détection secondaire (2a-c, 4) destiné à déterminer la position d'une plate-forme d'observation, un moyen (5) pour combiner les informations provenant des moyens de détection primaire (1, 3) et secondaire (2a-c, 4) afin de déterminer la position absolue dudit objet, des moyens (3, 5, 6) pour déterminer l'identité dudit objet, ledit dispositif comprenant en outre un moyen (C) destiné à assurer l'échange de données poste à poste entre les moyens correspondants (1-6) des systèmes de localisation géographique dans des lieux différents. Le moyen primaire de détection de direction ou de position (1, 3) peut comprendre des systèmes de recherche de direction, des radars ou des lidars.
Patent WO-2013095155-A1 (WO)
Title: Bouchon à utiliser pour la rénovation/réhabilitation de tuyauteries d'eau
Inventor: DALBY ROLF IVAR
IPC: E03F3/06
Filed: 2012-12-12
Abstract: L'invention concerne une méthode de rénovation ou de réhabilitation de tuyauteries d'alimentation en eau (1) qui ne nécessite pas l'excavation des tuyaux, des entrées latérales associées (4) ou des trous d'homme (7), etc., des agencements bouchons (10) étant installés dans les entrées latérales (4), un tube flexible (15) enduit d'adhésif (17) étant enfilé dans la tuyauterie d'alimentation en eau (1) et une certaine pression étant maintenue pendant une durée prédéterminée afin que le matériau adhésif (17) durcisse et que le tube (15) soit collé à la paroi intérieure du tuyau (2), les agencements bouchons montés (10) sont alors enlevés. L'invention concerne un agencement bouchon spécial (10, 11) à utiliser avec ladite méthode.
Patent WO-2013191562-A1 (WO)
Title: Packer for cable gland and use of the same
Inventor: LUND ASBJOERN
IPC: H02G15/013
Filed: 2013-06-19
Abstract: A packer (1) for use in a cable gland (2) is described, the packer (1) being characterized by being formed from an elastic material including coarse-grained particles of a hardness sufficient for engagement with the surface of a cable, which has been inserted into the cable gland (2), when pressure is applied around the packer (1), whereby the packer (1) substantially prevents the cable from slipping in the cable gland (2). A use of a packer (1) together with a cable gland (2) is described as well.
Patent WO-2017048132-A1 (WO)
Title: Method and system for processing a fluid produced from a well
Inventor: FREDHEIM ARNE OLAV
IPC: E21B43/36
Filed: 2016-09-15
Abstract: A method of processing a fluid produced from a well, the produced fluid being a high pressure fluid, the method comprising: reducing the pressure of the fluid to a reduced pressure such that a gas phase and a liquid phase are formed; separating the gas phase from the liquid phase thus forming a gas product and a liquid product; and storing the liquid product in a storage tank at a pressure such that the liquid product remains in a stable liquid phase during storage, wherein the reduced pressure is greater than atmospheric pressure.
Patent WO-2020076163-A1 (WO)
Inventor: JOHANSEN BÅRD MARIUS
IPC: E21B47/00
Filed: 2019-10-11
Abstract: A method of installing a plug in a well extending through a formation of the Earth and having a first seal between the casing and the tubing. The method comprises establishing a second seal within the tubing in proximity to said first seal, and establishing first passages through the tubing above both said first and second seals. A wet sealant is pumped into a space within the tubing above the second seal so that the sealant fills the tubing to a first height above the first passages whilst flowing through the first passages to fill the annulus to a second height greater than the first height, the sealant in the annulus between said first and second height representing a volume of over-displaced sealant. Pumping the wet sealant into a space within the tubing directly above the second seal comprises placing a landing structure within the tubing at or below said first height and above the first passages, and pumping a volume of sealant down the tubing and through the landing structure. Said volume of sealant is pumped down the tubing in a sealant train between a pair of wipers, wherein, upon landing on the landing structure, a lowermost wiper is arranged to open allowing sealant to flow through the landing structure.
Patent WO-2020130847-A1 (WO)
Title: Système et procédé d'évaluation de condition d'environnement de navire
Inventor: SWIDER ANNA
IPC: G01C9/00
Filed: 2019-12-19
Abstract: L'invention concerne un système et un procédé d'évaluation de condition d'environnement de navire, le système comprenant une unité de mesure de mouvement (4) à bord d'un navire (17) conçue pour détecter le mouvement du navire, l'unité de mesure de mouvement étant conçue pour émettre un signal de mouvement (1) du navire, un processeur (12, 15) conçu pour recevoir le signal de mouvement du navire et appliquer un opérateur d'énergie (2) au signal de mouvement afin de calculer un signal d'énergie (3) représentant la condition d'environnement du navire.
Patent WO-2004102520-A1 (WO)
Title: A display control system
Inventor: ENGEL GABRIEL DAMON
IPC: G02B27/22
Filed: 2004-05-17
Abstract: A display control system for a multi-layer display system including at least one multi-layer display unit (6). A multi-layer display unit includes multiple stacked or overlapped display layers (1a, 1b, 1c, 14, 15) each adapted to render display elements (2, 16B, 17B, 18B) thereon for viewing through the uppermost display layer. The level of difficulty for a user to view an overlapped image differs depending on the colour, brightness or type of images (for example text-on-text) being displayed and also the layer in which the image is being displayed and whether the image is currently active. At least any overlapping portion of display elements from different display layers are adjusted (automatically or by a user) in order to improve the viewing experience for a viewer. Types of adjustment possible include moving the images within their display layer or to an alternative display layer or altering their visual properties (such as colour, brightness, contrast etc).
Patent WO-2012015318-A1 (WO)
Title: Système de cogénération à puissance thermique variable
Inventor: CHOKARDELL FLORIN SILVIU GABRIEL
IPC: F02G1/00
Filed: 2011-07-29
Abstract: Dans un système de cogénération, le système de commande est agencé pour augmenter le taux d'alimentation en air et carburant du moteur et faire se mélanger un flux ou des flux d'air supplémentaires sur les têtes chauffantes du moteur avec les gaz de combustion autour des têtes chauffantes, en réaction à une demande au système de cogénération d'un niveau de croissance de la puissance thermique, de telle sorte que la puissance thermique du système de cogénération soit augmentée proportionnellement plus que toute augmentation de production d'énergie électrique.
Patent PE-20011168-A1 (PE)
Title: Tapa de filtrado para fluidos embotellados
Inventor: POIRIER MALCOLM D
IPC: C02F1/28
Filed: 2000-12-19
Abstract: QUE COMPRENDE: 1) UNA CAMARA QUE PUEDE CONECTARSE RESELLABLEMENTE A UN RECIPIENTE DE FLUIDO; 2) UNOS MEDIOS DE FILTRO COLOCADOS DENTRO DE DICHA CAMARA, DE MANERA QUE EL FLUIDO PASA POR DICHOS MEDIOS DE FILTRO AL SALIR DEL RECIPIENTE DE FLUIDO. DICHOS MEDIOS DE FILTRO COMPRENDEN UN INDICADOR DEL TERMINO DE SU VIDA UTIL; Y 3) UN DISTRIBUIDOR COMUNICADO CON DICHA CAMARA DE TAL MANERA QUE EL FLUIDO SALE DE DICHA CAMARA A TRAVES DE DICHO DISTRIBUIDOR. EL FLUJO DEL FLUIDO A TRAVES DEL DISTRIBUIDOR PUEDE SER CONTROLADO
Patent PE-20020761-A1 (PE)
Title: Heteroarilo urea como antagonistas de los receptores y5 del neuropeptido y
Inventor: DONG YOUHAO
IPC: A61P3/10
Filed: 2001-12-18
Abstract: SE REFIERE A COMPUESTOS DE FORMULA I DONDE =A-B= ES =C(R4)-C(R5)=; X=Y ES C(R5)=N, N=CR7. N=N, S; =A-B= ES =N-CR5=, X=Y ES N=CR7, CR6=N, S, O; =A-B= ES =CR4N=, X=Y ES C(R6)=N, S, O; =A-B= ES =N-N=; X E Y ES S, O; =A-B= ES =CR4; X=Y ES S-N=, NCR10N; =A-B= ES =NCR4=; X=Y ES N-S, =N-NR10; Z ES ARIL, TIOFENO SUSTITUIDO CON R8; R1 ES H, ALQUILO C1-C6, R2 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, ALQUIL C1-C6-CICLOALQUILO C3-C6; R3 ES UN GRUPO a, b, c, ENTRE OTROS; Q ES OR13, NR13R14; j ES 1-2; k, l, m SON 0-2; R4, R5, R6 Y R7 SON H, OH, HALOGENO, POLIHALOALQUILO, ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS; R8 ES H, HALOGENO, OH, POLIHALOALQUILO, CN, NR10R11, NR13R14, ENTRE OTROS; R9 ES SO2-ALQUILO C1-C6, SO2-ARILO, CONR13R14, ENTRE OTROS; R10 ES H, ALQUILO; R11 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS; R12 ES ALQUILO C1-C8, CICLOALQUILO C3-C7; R15 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE UN AGONISTA ß3, UN AGENTE TIROMIMETICO, UN AGENTE MODIFICADOR DE LOS HABITOS ALIMENTICIOS, ANTAGONISTA DEL NPY, INHIBIDOR DE ALDOSA REDUCTASA, INHIBIDOR DE GLICOGENO FOSFORILASA, INHIBIDOR DE SORBITOL DESHIDROGENASA, INSULINA, METFORMIN, ACARBOSA, TIAZOLIDINDIONA, GLITAZONA, SULFONILUREA. LOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES Y5 DEL NEUROPEPTIDO Y; PUEDEN SER UTILES PARA TRATAR TRASTORNOS DE LA ALIMENTACION, METABOLICOS (BULIMIA, ANOREXIA), CELULITIS, ACUMULACION DE GRASAS, DIABETES, RESISTENCIA A LA NSULINA
Patent PE-20050952-A1 (PE)
Title: Derivados de isoquinolina como inhibidores de b-raf
Inventor: FINK CYNTHIA ANNE
IPC: C07D413/14
Filed: 2004-09-22
Abstract: SE REFIERE A COMPUESTOS DERIVADOS DE ISOQUINOLINA DE FORMULA (I), EN DONDE n, r SON DE 0 A 2; m ES DE 0 A 4; J ESTA OPCIONALMENTE SUSTITUIDO UNA O DOS VECES POR Q, J ES ARILO(C6-C14) COMO FENILO, NAFTILO, FLUORENILO Y FENANTRENILO, HETEROARILO(C4-C14) COMO FURILO, PIRANILO, PIRIDILO, ENTRE OTROS, CICLOALQUILO(C3-C8) COMO CICLOPROPILO, CICLOPENTILO, Y CICLOHEXILO, HETEROCICLOALQUILO(C3-C8) COMO PIPERIDILO, PIPERAZINILO, IMIDAZOLINILO, ENTRE OTROS; Q ES HALOGENO, ALQUILO INFERIOR, -OR2, -SR2, ENTRE OTROS; X ES Y, -N(R), OXA, TIO, SULFONA, ENTRE OTROS; Y ES H, ALQUILO INFERIOR, ARILO COMO FENILO OPCIONALMENTESUSTITUIDO, ENTRE OTROS; Z ES AMINO, HALOGENO, ALQUILO ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (4-TER-BUTIL-FENIL)-[6-FLUORO-4-(2-MORFOLIN-4-IL-PIRIMIDIN-4-IL)-ISOQUINOLIN-1-IL)-AMINA, [4-(2-MORFOLIN-4-IL-PIRIMIDIN-4-IL)-ISOQUINOLIN-1-IL]-(3-TRIFLUOROMETILOXI-FENIL)-AMINA, (4-TER-BUTIL-FENIL)-{4-[2-(4-TRIFLUOROMETIL-PIPERIDIN-4-IL)-PIRIMIDIN-4-IL]-ISOQUINOLIN-1-IL}-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS INHIBEN LA CINASA B-RAF (UNA SERINA/TREONINA CINASA) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS COMO EL CANCER
Patent PE-20051003-A1 (PE)
Title: Proteccion para agujas
Inventor: SIRCOM RICHARD C
IPC: A61M5/32
Filed: 2005-02-14
Abstract: SE REFIERE A UN DISPOSITIVO PROTECTOR DE AGUJA, QUE COMPRENDE: A)UN RECIPIENTE DE CONTENCION, TAL COMO UNA CAVIDAD QUE RECIBE A UNA AGUJA; B)UNA PLACA DE INCLINACION DENTRO DE LA CAVIDAD, QUE PRESENTA UN ORIFICIO A TRAVES DEL CUAL SE RECIBE LA AGUJA ESTANDO LA CARA INTERNA DE LA SUPERFICIE DEL ORIFICIO RODEADA POR UN PRIMER Y UN SEGUNDO BORDE CIRCUNFERENCIAL QUE PERMITEN UN ENCAJE PERFECTO POR DESLIZAMIENTO ALREDEDOR DE LA AGUJA; C)UN BRAZO SENSOR ACOPLADO A LA PLACA DE INCLINACION PARA ALINEAR LOS BORDES CIRCUNFERENCIALES DE MODO QUE ENCAJEN POR DESLIZAMIENTO CON LA AGUJA MIENTRAS LA PUNTA DE LA AGUJA SOBRESALE DEL RECIPIENTE DE CONTENCION; Y, D)MEDIOS DE INCLINACION FLEXIBLES QUE ACTUAN ENTRE EL RECIPIENTE, EL BRAZO SENSOR Y LA PLACA DE INCLINACION PARA PROVOCAR LA ROTACION DE LA PLACA DE INCLINACION RESPECTO DE LA AGUJA CUANDO LA PUNTA DE LA AGUJA SE RETRAE EN LA CAVIDAD DE CONTENCION. ADEMAS DE UN ELEMENTO SENSOR EN EL BRAZO SENSOR; UN PRIMER Y UN SEGUNDO PUNTO DE PRESION PRESENTES EN LA PLACA DE INCLINACION Y EN EL BRAZO SENSOR; Y, UN PRIMER Y UN SEGUNDO MEDIO DE TOPE PRESENTES Y TRASLADADOS DENTRO DE LA CAVIDAD DEL RECIPIENTE DE CONTENCION. ESTE PROTECTOR SE PUEDE APLICAR A CUALQUIER DISPOSITIVO PUNZANTE SIMILAR A UNA AGUJA O ALAMBRE QUE EXIJA PROTECCION, PARA EVITAR QUE LAS PERSONAS QUE UTILIZAN TALES DISPOSITIVOS SUFRAN LESIONES PUNZANTES
Patent PE-20070374-A1 (PE)
Title: ANTICUERPOS ANTI-MAdCAM
Inventor: PULLEN NICHOLAS
IPC: C07K16/28
Filed: 2006-07-05
Abstract: REFERIDA A UN ANTICUERPO MONOCLONAL QUE SE UNE ESPECIFICAMENTE A LA MOLECULA DE ADHESION CELULAR DE ADRESINA DE LA MUCOSA (MAdCAM), O PARTE DE UNION A ANTIGENO DEL MISMO, EL CUAL SE SELECCIONA DE ENTRE: a) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA PESADA DE 6.22.2-MOD_V (SEC ID Nº:2), b) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA LIGERA DE 6.34.2-MOD_SSQ, 6.34.2-MOD_QT, O 6.34.2-MOD_SSQ,QT (SEC ID Nº:8, 10, 12), UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA LIGERA DE 6.67.1-MOD_Y, 6.67.1-MOD_TAP, O 6.67.1-MOD_Y, TAP (SEC ID Nº:16, 18, 20), d) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA PESADA DE 6.77.1-MOD_AS (SEC ID Nº:22), e) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA PESADA DE 7.16.6_L (SEC ID Nº:28), f) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA LIGERA DE 7.16.6_V, 7.16.6_S, O 7.16.6_VS (SEC ID Nº: 30, 32, 34), g) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA LIGERA DE 7.16.6_V, 7.16.6_S, O 7.16.6_VS (SEC ID Nº:30, 32, 34) Y LA REGION VARIABLE DE LA CADENA PESADA DE 7.16.6_L (SEC ID Nº:28), h) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA PESADA DE 9.8.2-ARGAYH, D (SEC ID Nº:36), i) UN ANTICUERPO QUE COMPRENDE LA REGION VARIABLE DE LA CADENA LIGERA DE 9.8.2-MOD (SEC ID Nº:38). DICHO ANTICUERPO ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS TALES COMO ENFERMEDAD INFLAMATORIA DEL INTESTINO
Patent PE-20080138-A1 (PE)
Title: Procesos para preparar conjugados de polietilen glicol solubles en agua de inmunosupresores macrolidos
Inventor: GU JIANXIN
IPC: A61K47/48
Filed: 2007-03-05
Abstract: SE REFIERE A UN PROCESO PARA PREPARAR CONJUGADOS DE POLIETILEN GLICOL SOLUBLES EN AGUA DE MACROLIDOS INMUNOSUPRESORES, QUE COMPRENDEN: a) HACER REACCIONAR UN AGENTE ACILADOR CON UN MACROLIDO INMUNOSUPRESOR QUE TIENE UNA REGION CICLOHEXILO DERIVADA DEL ACIDO SHIKIMICO EN PRESENCIA DE UNA LIPASA PARA FORMAR UN MACROLIDO ACILADO; b) HACER REACCIONAR EL MACROLIDO ACILADO CON UN DERIVADO DE METOXI POLI(ETILEN GLICOL) O UN DERIVADO DE POLI(ETILEN GLICOL) TIOL TERMINAL, EN PRESENCIA DE UNA BASE. DONDE DICHO MACROLIDO INMUNOSUPRESOR ES RAPAMICINA (SIROLIMUS) O DERIVADOS TAL COMO EVEROLIMUS, TEMSIROLIMUS (CCI-779) REGIOESPECIFICAMENTE ACILADA EN LA POSICION 42, O TACROLIMUS (FK506) Y ASCOMICINA (FK520) REGIOESPECIFICAMENTE ACILADAS EN LA POSICION 32, ENTRE OTROS. ESTOS COMPUESTOS SUPRIMEN LA ACTIVIDAD DE LAS CELULAS T Y PRESENTAN ACTIVIDAD ANTIMICROBIANA
Patent PE-20080188-A1 (PE)
Title: Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol
Inventor: KUO GEE-HONG
IPC: C07D409/02
Filed: 2007-04-16
Abstract: SE REFIERE A UN COMPUESTO DE FORMULA I DONDE X ES UN ENLACE COVALENTE, O, S; R1 y R2 SON CADA UNO H, ALQUILO C1-C8 SUSTITUIDO O NO O FORMAN JUNTO AL ATOMO DE CARBONO CICLOALQUILO C3-C7; R3 ES H; R4 y R5 SON CADA UNO H, HALO, ALQUILO C1-C8, ENTRE OTROS; R6 y R7 SON CADA UNO H, HALO, ALQUILO C1-C3, ALCOXI C1-C3, ENTRE OTROS; n ES 1; Q ES 1,2-TIAZOL, TIAZOL, TIOFENO, 3-METILTIAZOL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO {3-[3-(4-TRIFLUOROMETIL-FENIL)ISOTIAZOL-5-ILMETIL]-2,3,4,5-TETRAHIDRO-1H-BENZO[d]AZEPIN-7-ILOXI)-ACETICO; ACIDO 2-METIL-2-{3-[3-(4-TRIFLUOROMETIL-FENIL)-ISOTIAZOL-5-ILMETIL} 2,3,4,5-TETRAHIDRO-1H-BENZO[d]AZEPIN-7-ILOXI}-PROPIONICO; ENTRE OTROS. SE REFIERE TAMBIEN UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS SON AGONISTAS DE RECEPTORES ACTIVADOS POR EL PROLIFERADOR DE PEROXISOMA (PPAR), UTILES EN EL TRATAMIENTO DE NEUROPATIA, RETINOPATIA, NEFROPATIA, CATARATAS, ATEROSCLEROSIS Y OTROS TRASTORNOS RELACIONADOS
Patent PE-20090445-A1 (PE)
Title: Inhibidores de produccion de beta amiloide
Inventor: CAGGIANO THOMAS J
IPC: A61K31/381
Filed: 2008-07-14
Abstract: SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES ARILO SUSTITUIDO O NO, HETEROARILO SUSTITUIDO O NO; R2 ES HALOALQUILO SUSTITUIDO O NO; R3 ES ARILO SUSTITUIDO O NO, HETEROARILO SUSTITUIDO O NO. SON COMPUESTOS PREFERIDOS: 5-CLORO-N-[3,3,3-TRIFLUORO-1-(HIDROXIMETIL)-2-FENILPROPIL]TIOFEN-2-SULFONAMIDA; 5-CLORO-N-[(1S,2S)-2-(DIFLUOROFENIL)-3,3,3-TRIFLUOR-1-(HIDROXIMETIL)PROPIL]TIOFEN-2-SULFONAMIDA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA PRODUCCION DE BETA AMILOIDE, UTILES EN EL TRATAMIENTO DE ALZHEIMER