Patent SG-11201804885T-A (SG)
Title: Monomaleimide-functionalized platinum compounds for cancer therapy
Inventor: KOWOL CHRISTIAN
IPC: A61K33/24
Filed: 2016-12-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MINIIII101110101011111 HO 11111 0011111110 Ell H 11011111111111111110111111 International Bureau .. .....Yi j .... ...,,,' (10) International Publication Number (43) International Publication Date WO 2017/097986 Al 15 June 2017(15.06.2017) WIPO I PCT (51) International Patent Classification: (AT). PICHLER, Verena; Antonigasse 54/14, 1180 Wien C07F 15/00 (2006.01) A61P 35/00 (2006.01) (AT). A61K 33/24 (2006.01) (74) Agent: MEIER, JURGEN, VOSSIUS & PARTNER (No (21) International Application Number: 31); SiebertstraBe 3, 81675 Miinchen (DE). PCT/EP2016/080453 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 9 December 2016 (09.12.2016) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (25) Filing Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 15198739.3 9 December 2015 (09.12.2015) EP NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (71) Applicants: MEDIZINISCHE UNIVERSITAT WIEN RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, [AT/AT]; Spitalgasse 23, 1090 Wien (AT). UNI- TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, VERSITAT WIEN [AT/AT]; Universitatsring 1, 1010 ZA, ZM, ZW. Wien (AT). (84) Designated States (unless otherwise indicated, for every (72) Inventors: KOWOL, Christian; Einwanggasse 6/14, kind of regional protection available): ARIPO (BW, GH, 1140 Wien (AT). HEFFETER, Petra; Landstrasser GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Hauptstrasse 121/2, 1030 Wien (AT). BERGER, Walter; TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, = Hiitteldorferstrasse 227/5, 1140 Wien (AT). KEPPLER, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Bernhard K.; Dr. Baumgartnerstrasse 18, 1291 Gaweinstal DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (AT). MAYR, Josef; Sandauergasse 2/37, 1210 Wien LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, [Continued on next page] = _ = = = = = = = R3 R 4...---' ,-, GC t:t IN O 1 © IN Il © ei O (54) Title: MONOMALEIMIDE-FUNCTIONALIZED PLATINUM COMPOUNDS FOR CANCER THERAPY - Pt -'...'''.\" R 2 (57) : The present invention relates to novel mono- 0 maleimide-functionalized platinum compounds of formula (I), including in particular novel monomaleimide-functional- ized oxaliplatin and carboplatin derivatives, as well as their use as medicaments, particularly for the treatment or preven- tion of cancer. 1 R ( I ) O WO 2017/097986 Al 011 0 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Published: GW, KM, ML, MR, NE, SN, Declarations under Rule 4.17: TD, TG). — with international search report (Art. 2 1 (3)) — before the expiration of the time limit for amending the — as to applicant's entitlement a patent (Rule 4.1700) to apply for and be granted claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of