baber/WOPTO huggingface dataset:
Patent IE-830976-L (IE)
Title: 3-(arylthiomethyl)pyridines.
IPC: A61K31/325
Filed: 1983-04-28
Abstract: Thiomethylpyridine derivatives having bronchosecretolytic and mucolytic activity according to the formula:    <IMAGE>  (I)  wherein R is a group attached in the 2-, 3- or 4-position of the pyridine ring which corresponds to the following general formula: Q-S-CH2-(II) wherein Q is a substituted or unsubstituted aryl group or a 5- or 6-membered heterocyclic group which may optionally contain one or more substituents and/or which may be condensed with an optionally substituted phenyl group or with an optionally substituted heterocycle; R' is a lower alkyl group, a halogen atom or an aminoalkyl group; and n is 0 or an integer of from 1 to 4; and the therapeutically-acceptable acid addition salts thereof. The new compounds are distinguished by surprising activity compared with known compounds, such as "Ambroxol".
Patent FI-852093-L (FI)
Inventor: MACDONALD PETER
IPC: C07J71/00
Filed: 1985-05-24
Abstract: @ A process for the preparation of 16,17 acetals of pregnane derivatives by trans-ketalization of 16,17-acetonides is described.In the instance of the preparation of 16a,17a-butylide- nedioxy-11β,21-dihydroxypregna-1,4-diene-3,20-dione, a compound having useful therapeutic properties, known also as budesonide, it is possible to obtain the more active epimer with high selectivity and remarkable economic advantages in comparison with the known methods.New 16,17 acetals of pregnane derivatives, which can be prepared by the method of the invention, are also described.
Patent IE-41197-L (IE)
Title: 4H -s- TRIAZOLO [4,3-a] (1,5) BENZODIAZEPIN-5-ONES
IPC: C07C233/88
Filed: 1974-05-14
Abstract: Compounds of the following formula <IMAGE> are useful as central nervous system depressants, tranquilizers, sedatives, growth promotors, anti-convulsants and muscle relaxants in mammalian species.
[US4133809A]
Patent IE-40147-L (IE)
Title: Drilling fluids
IPC: C09K8/22
Filed: 1974-05-24
Abstract: 1443654 Fluids for drilling wells TEXACO DEVELOPMENT CORP 8 May 1974 [25 May 1973] 20268/74 Heading C5F Aqueous drilling fluid comprises at least one dispersant, hydratable clayey material, weighting agent and/or water loss improving agent and an aqueous phase containing a minor amount of at least one phosphate compound selected from (A) compounds of the Formula I wherein n is from 4 to 50, R is a C 8-12 alkyl group, R<SP>a</SP> is hydrogen or a C 8-12 alkyl group, R<SP>b</SP> is hydrogen, a compound of the Formula III or M, M is an alkali metal or ammonium radical, and R<SP>c</SP> is hydrogen or M, and (B) compounds of the Formula II wherein n is from 4 to 50, R<SP>d</SP> is a (C 8-20 alkyl radical, R<SP>e</SP> is hydrogen, R<SP>d</SP>(OCH 2 CH 2 ) n -, or M, and R<SP>f</SP> is hydrogen or M. The drilling fluid suitably contains 0À01-25 wt. per cent of the phosphate compound. The fluid exemplified can have sodium chloride brine as the aqueous phase and can also comprise ferrochromelignosulphonate, attapulgite clay, calcium hydroxide and/or barite. The phosphate compounds used in the examples are (a) a mixture of compounds of the Formula II wherein the alkyl group R<SP>d</SP> is derived from C 12-16 alcohols, and n is an average of 7, (b) a compound of the Formula IV (c) a compound of the Formula V and (d) a compound of the Formula VI
[GB1443654A]
Patent IE-45329-L (IE)
Title: Phenyl benzyl ethers
IPC: C07C59/68
Filed: 1977-08-04
Abstract: Compounds of the formula <IMAGE> wherein R1 and R2 are each hydrogen, chlorine or fluorine; and R3 is -CH2OH, -CH2-O-COR4, -CH2-O-CONHR5, -COOH, -COOCat, -COOR6, -CONR7R8 or -CO-SR9; where Cat is one equivalent of an inorganic or organic cation; R4 is hydrogen or alkyl of 1 to 10 carbon atoms; R5 is alkyl of 1 to 4 carbon atoms, phenyl or halo-substituted phenyl; R6 is alkyl of 1 to 10 carbon atoms which may optionally have a chloro, hydroxyl, lower alkoxy, lower alkoxy-lower alkoxy, lower alkylthio, amino, mono-lower alkyl-amino, di-lower alkyl-amino, allyloxy or phenoxy substituent attached thereto; phenyl; benzyl; monochloro-benzyl; dichloro-benzyl; cyclohexyl; 1-ethynyl-cyclohexyl; lower alkenyl; lower alkynyl; -N=C(CH3)2; 2-(2',4',5'-trichloro-phenoxy)-ethyl, 2-(2', 5'-dichloro-4'-bromo-phenoxy)-ethyl; or <IMAGE> R7 is hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkenyl, lower alkynyl, phenyl, chloro-substituted phenyl, hydroxyl, amino, phenyl-amino or thiazolyl; R8 is hydrogen, lower alkyl, lower alkenyl or hydroxy-lower alkyl; R9 is hydrogen or alkyl of 1 to 10 carbon atoms; and N IS AN INTEGER FROM 2 TO 6, INCLUSIVE.
[US4169720A]
Patent IE-891762-L (IE)
Title: New Heparin Derivatives and Process for their Preparation
IPC: C08B37/10
Filed: 1989-06-12
Abstract: New heparin derivatives having antithrombotic activity, also endowed with reduced hemorrhagic and anticoagulant effects, obtained by treating in a basic medium heparins of various origin, optionally in the presence of alkali metal salts and of a reducing agent. The heparin derivatives obtained through this treatment show peculiar chemico-physical characteristics, like new signals at about 53 and 54 p.p.m. in the <1><3>C-NMR spectrum and a raise of the specific rotatory power, compared to that of the starting heparins, to values between +50 DEG  to +90 DEG . Said structural modifications produce an improvement of the biological properties of the heparin, substantially keeping the antithrombotic activity while diminishing the hemorrhagic effect in vivo and the anticoagulant activity in vitro.
Patent IE-41651-L (IE)
Title: Heterocyclyl guanidines
IPC: C07D261/08
Filed: 1975-08-12
Abstract: Process for preparing N-cyanoguanidines by treating N-(loweralkyl)-N'-cyano-isothioureas with an amine and a heavy metal salt. A specific product is N-cyano-N'-methyl-N''-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guan idine, useful as a histamine H2 -antagonist.
[US4049671A]
Patent IE-891815-L (IE)
Title: Hirudin derivatives with delayed action
IPC: A61K47/48
Filed: 1989-06-12
Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.
Patent IE-792237-L (IE)
Title: Telecommunications system
IPC: H04M15/00
Filed: 1979-11-22
Abstract: A telephone system has a plurality of communication terminals and portable communication units for certain users. Each communication unit includes a transmitter and receiver enabling coupling to any of the communication terminals over a short range. In order to make a call the user positions himself within some standard range (e.g. 5 meters) of any one of the communication terminals and then operates his communication unit to gain access to the telephone system by way of the communication terminal. The portable communication unit comprises a push-button dialler, a liquid crystal display and integral earpiece and microphone. Access to the telephone system is gained by ie performing an interactive key code sequence using the communications unit. When access is confirmed by the communication terminal the user keys in the required telephone number and when the call is established the terminal indicates call cost information over the reverse speech link. The unit includes a PROM as a credit meter and the cost information cancels the requisite credit from the memory.
[GB2046556A]
Patent IE-812315-L (IE)
Title: Cephalosporins
IPC: C07D501/36
Filed: 1981-10-05
Abstract: There is presented compounds of the formula    <IMAGE>  I  wherein X represents the 1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl group or its corresponding tautomeric form, the 2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl group, and the readily hydrolyzable esters, readily hydrolyzable ethers and salts of the compounds and hydrates of the compounds of formula I or of their esters, ethers and salts. Also provided is a method of their manufacture and intermediates therefor as well as corresponding pharmaceutical preparations.
Patent IE-822486-L (IE)
Title: 3-benzazepines as alpha-2-antagonists
IPC: A61K31/33
Filed: 1982-10-14
Abstract: Pharmaceutical Compositions and Method of Producing Alpha2 Antagonism Pharmaceutical compositions and method of producing alpha2 antagonism by administering N-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines. These compositions are particularly useful for lowering intraocular pressure and for the treatment of cardiovascular conditions such as, for example, congestive heart failure, angina pectoris, and thrombosis. The compositions and compounds of this invention also produce a reduction in blood pressure and are therefore useful as antihypertensive agents.
[CA1214165A]
Patent IE-42064-L (IE)
Title: Triazole derivatives
IPC: C07D409/14
Filed: 1975-11-17
Abstract: Novel 1-(ss-aryl)-ethyl-1H-1,2,4-triazol ketals of the formula <IMAGE> in which Z and Ar are as defined in Claim 1, are obtained by reacting a metal salt of 1H-1,2,4-triazol with a halide carrying the radical <IMAGE> The novel compounds are used as fungicides.
[GB1522657A]
Patent IE-842797-L (IE)
Title: Nail coating compositions
IPC: A61K8/00
Filed: 1984-10-31
Abstract: Nail polish compositions comprising pigment material, and film forming material, wherein the pigment material is present in amounts not less than about 2.0% by weight and said nail polish composition has a Newtonian viscosity not greater than about 600 cps.
[EP0154679A2]
Patent IE-832867-L (IE)
Title: Pyrrolidine derivatives
IPC: C07D207/24
Filed: 1983-12-06
Abstract: Pyrrolidine derivatives of the formula:   <IMAGE>   wherein X represents an oxygen or sulphur atom, R represents a hydrogen atom or an alkyl radical, Ro represents a hydrogen atom, an alkyl radical or a phenyl radical optionally substituted by a halogen atom or by an alkyl, alkoxy, alkylthio or nitro radical, A represents a nitrogen atom or a radical =CH-, the symbol Y represents a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, alkylcarbonyl, nitro, amino, alkylcarbonylamino, alkylamino, dialkylamino, alkylsulphinyl, alkylsulphonyl, alkoxycarbonyl, cyano, trifluoromethyl, hydroxy, mercapto, alkylcarbonyloxy or alkylcarbonylthio radical, n represents zero or 1, and p represents 1, 2 or 3, it being understood that the alkyl and alkoxy radicals, and alkyl and alkoxy moieties of any of the aforementioned groups, contain from 1 to 4 carbon atoms are new therapeutically useful compounds, more particularly useful as antidepressants.
Patent IE-883853-L (IE)
Title: Catheter
IPC: A61M25/00
Filed: 1988-12-22
Abstract: A medical catheter for example for drainage of a bodily fluid such as urine, comprises a biodegradable portion (18) which degrades throughout the period in which the catheter is in place in a body cavity, and thereby resists infection or the formation of encrustation or blockages normally associated with indwelling catheters.
Patent IE-894108-L (IE)
Title: Sulfonic acid substituted aromatic steroids as inhibitors of¹steroid 5ó-reductase
IPC: C07J13/00
Filed: 1989-12-20
Abstract: Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5- alpha -reductase, including using these compounds to reduce or maintain prostate size. Also invented are intermediates used in preparing these compounds.
[US4970205A]
Patent NO-760641-L (NO)
Inventor: HARTZ P
IPC: B63B21/08
Filed: 1976-02-25
Abstract: Trossestopper.
Patent NO-762381-L (NO)
Inventor: WINAND R
IPC: C25C3/30
Filed: 1976-07-08
Abstract: Elektrolysecelle.
Patent NO-820705-L (NO)
Inventor: FISCHER ARTUR
IPC: F16B13/06
Filed: 1982-03-05
Abstract: 1. Metal fastening element comprising a stay bolt (1) having a portion with an external thread (10) onto which a nut (11) can be screwed, and having an expansion cone (2) at its front end, and a sleeve (3) placed over the stay bolt (1), which sleeve is slotted from its lead-in end over part (3a) of its length, characterised in that after the slotted part (3a) of the sleeve the external diameter of the sleeve (3) is reduced over part of its length in a direction towards that end of the sleeve that is opposite the lead-in end.
Patent NO-852320-L (NO)
Inventor: FAU ALAIN
IPC: C08J3/02
Filed: 1985-06-10
Abstract: Storage-stable, aqueous polysiloxane emulsions well adopted as coating compositions to impart anti-adhesiveness/water-repellency to a wide variety of substrates, e.g., paper, are comprised of an anti-adhesive/water-repellency effective amount of (A) diorganopolysiloxane oil having the formula: HO(SiR2O)nH wherein the symbols R, which may be identical or different, are each an alkyl radical containing from 1 to 3 carbon atoms, the 3,3,3-tri-fluoropropyl radical, or the vinyl radical, at least 50% of the radicals R being methyl radicals and at most 5% vinyl radicals, and the symbol n is any number, the value of which is such that the viscosity of the oil ranges from 500 to 50,000 mPa.s at 25 DEG  C.; (B) an organopolysiloxane resin comprising recurring units selected from among those of the formulae R'SiO1.5, R'2SiO and R'3SiO0.5, in which the symbols R', which may be identical or different, are each an alkyl radical containing from 1 to 3 carbon atoms, or the vinyl radical, at least 70% of the radicals R' being methyl radicals, and said units being distributed such as to provide a R'/Si ratio ranging from 1.05 to 1.85; (C) a liquid organohydropolysiloxane containing at least 3 hydrogen atoms per molecule directly bonded to silicon atoms, said organic groups bonded to the silicon atoms being R' radicals as defined above, at least 80% of said radicals being methyl radicals; (D) a thickening amount of a thickening agent; (E) a water-repellency effective amount of a vinyl acetate homo- or copolymer; (F) a polyvinyl alcohol; (G) an emulsifying amount of a non-ionic emulsifier; and (H) water.
Patent NO-853366-L (NO)
Inventor: PARSLOW MICHAEL W
IPC: C11D3/30
Filed: 1985-08-27
Abstract: The invention pertains to detergent compositions for simultaneously cleaning and softening fabrics comprising detergent-active materials, a primary or secondary amine and cellulase. The compositions combine good cleaning performance with effective textile softening performance on a wide range of textile materials.
Patent NO-872827-L (NO)
Inventor: STEENHUISEN JOHANNES E
IPC: A61L2/26
Filed: 1987-07-07
Abstract: The invention relates to a holder for a plurality of disposable syringes, the syringes comprising a barrel (11), a needle connection means (19) on the front end of the barrel, in which or to which an injection needle (13) is or can be sealingly connected, and a finger grip (16), provided with an outwardly projecting flange (31) and optionally with a clamping sleeve (18) for a clamping connection around the rear open end of the barrel. The holder comprises comprises a strip (24) of flexible material one side of which comprises a number of resilient projections (23), distributed over the surface, for a detachable connection of the syringes in such a way that the rear end of the barrel or the rear face of the finger grip (16) adjoins the surface of the strip in a non-sealing manner.
Patent NO-891071-L (NO)
Inventor: KROGSGAARD-LARSEN POVL
IPC: A61K/
Filed: 1989-03-13
Abstract: Novel compounds of the formula: <CHEM>  wherein R<1>, R<2>, R<3> and R<4> are as defined in Claim 1, as well as individual isomers and pharmaceutically acceptable acid addition salts are described as having acetylcholine agonistic activity making them useful in the treatment of diseases of the brain, e.g. Alzheimer's disease. Methods for the preparation of the novel compounds are also described, as well as pharmaceutical compositions containing same.
Patent NO-892805-L (NO)
Inventor: DEVIC MICHEL
IPC: D21C3/04
Filed: 1989-07-06
Abstract: Process for manufacturing bleached CTMP pulps comprising a treatment of the lignocellulosic stock with sulphite at a temperature of at least 100 DEG C under saturated steam pressure, and a bleaching operation with the aid of H2O2 in alkaline medium without removal of solid or liquid matter from the pulp from the start of the treatment until the end of the bleaching.
Patent NO-912059-L (NO)
Inventor: ROUSSEAU EMMANUEL
IPC: H04L27/233
Filed: 1991-05-29
Abstract: The present invention relates to a digital signal processing device which comprises:     - an adder (61),   - a random-access memory (51), - a controlled inversion circuit (70) providing the absolute value (A), the true value or the opposite value (0) of the signal applied to its input, - a read-only memory (52) preserving in a location the square of the address of this location, - a first multiplexing circuit (41, 42) producing the first operand (M2) from, among other things, a digital sample (M1),   - a second multiplexing circuit (43, 44), - a sequencer (10) comprising means of selectively controlling the random-access memory (51), the controlled inversion circuit (70), the first (41, 42) and second (43, 44) multiplexing circuits, in such a way as to effect in particular a correction of the DC component and a frequency-translation on a sample, and a measurement of power on a series of samples.   <IMAGE>
Patent NO-921734-L (NO)
Inventor: EMONDS-ALT XAVIER
IPC: A61P29/00
Filed: 1992-04-30
Abstract: The invention relates to compounds of formula (I): <IMAGE>  in which     - Y represents - either a Cy-N or Cy-CH2-N group in which Cy represents an optionally substituted phenyl;   - or a group <IMAGE> in which     .Ar represents an optionally substituted phenyl;   .x is zero or one; .X represents a hydrogen, a hydroxyl, an alkoxy; an acyloxy; a carboxy; a carbalkoxy; a cyano; a -N(X1)2 group in which the groups X1 independently represent hydrogen, an alkyl, a hydroxyalkyl, an acyl, or alternatively -(X1)2 constitutes, with the nitrogen atom to which it is attached, a heterocycle; an -S-X2 group in which X2 represents hydrogen or an alkyl group; or alternatively X forms, with the carbon atom to which it is attached and with the adjacent carbon atom in the heterocycle, a double bond;     - m is 2 or 3; - Ar' represents an optionally substituted phenyl or a phenyl substituted one or more times with a thienyl; a benzothienyl; a naphthyl or an indolyl;   - n is 0, 1, 2 or 3; - p is 1 or 2 and when p = 2, then n = 1 and Q represents two hydrogen atoms;   - Q represents oxygen or two hydrogen atoms;   - T represents a group chosen from <IMAGE>   - q is 0, 1, 2 or 3; - Z represents an optionally substituted phenyl; an optionally substituted naphthyl; a pyridyl; a thienyl; an indolyl; a quinolyl; a benzothienyl; an imidazolyl; or alternatively, when T is -C=O, -(CH2)q-Z may also represent a benzyl group substituted on the -CH- and optionally substituted on the aromatic ring; an optionally substituted mono-, di- or tricyclic aromatic or heteroaromatic group;   or one of their possible salts with inorganic or organic acids, or when <IMAGE> one of their quaternary ammonium salts with the nitrogen (b) of piperidine or N-oxide derivatives with the same nitrogen atom. The invention also relates to the process for preparing them and to their enantiomers. Application: antagonists of neurokinin receptors.
Patent NO-924555-L (NO)
Inventor: STANWORTH DENIS RAYMOND
IPC: C07K7/06
Filed: 1992-11-25
Abstract: The assay of rheumatoid arthritis by reference to IgA- alpha 1 antitrypsin complex present in analytes is facilitated by certain novel antibody reagents. These are ligands comprising an antibody domain specific for an antigenic determinant of a complex of human IgA and  alpha 1-antitrypsin, this antibody domain being substantially non reactive with free human IgA and free human  alpha 1-antitrypsin. Monoclonal antibodies to the naturally occurring IgA- alpha 1AT complex and monoclonal or polyclonal antibodies to a synthetic peptide are preferred. The synthetic peptide in itself part of the invention and preferably has an amino acid sequence: Val-Ser-Val-Val-Met-Ala-Glu-Val-Asp-Gly-Thr-Cys-Tyr (SEQ ID NO:
Patent NO-930406-L (NO)
Title: Spesifikke antistoffer mot aktiverte blodplater samt fremstilling derav
Inventor: BOSSLET KLAUS
IPC: C12N1/15
Filed: 1993-02-05
Abstract: Monoklonale antistoffer og deler derav som fortrinnsvis bindes til aktive humane blodplater, nukleotid- og aminosyresekvens til tunge og lette kjeder av MAK BW 2128 og et med thrombospondin assosiert antigen, er beskrevet.
Patent NO-931627-L (NO)
Inventor: BAUMANN KARL
IPC: C07D/
Filed: 1993-05-05
Abstract: The invention concerns the compounds of formulae <CHEM> wherein the substituents have various significances. They can be prepared by various methods, e.g. acylation, reduction, alkylation, etc. They are indicated for use as pharmaceuticals, in particular as immunosuppressant, antiproliferative and antiinflammatory agents.
Patent NO-941781-L (NO)
Title: Ikke-radioaktiv immunanalyse
Inventor: SCHULTZ JOHN W
IPC: C12Q1/42
Filed: 1994-05-11
Abstract: Analysebestemmelse og rensing av proteiner, og spesielt en ikke-radio-aktiv analysebestemmelse og rensing av proteinkinaser, fosfataser og prote-aser, ved inkubasjon av enzymet med et modifisert substratpeptid for å danne et modifisert produktpeptid under be-tingelser hvor enzymet er aktivt. Det modifiserte produktpeptid og det modifiserte substratpeptid atskilles der-etter, og det modifiserte produktpeptid måles. Analysesett og biologiske reagenser for utførelse av analyse-bestemmelsene er også beskrevet.
Patent NO-942197-L (NO)
IPC: G01N33/92
Filed: 1994-06-10
Abstract: Low density lipoprotein are directly determined in body fluids by selectively precipitating very low density lipoprotein, forming clusters with low density lipoproteins, selectively consuming the high density lipoproteins, and resolubilizing the low density lipoproteins for direct determination thereof. The clusters are formed by treating the fluid sample with a mixture of a polyanionic compound, a divalent metal, and a nucleating agent.
Patent NO-942350-L (NO)
Title: Peptidforbindelse med terapeutisk aktivitet
Inventor: PIERSON MYLES EDWARD
IPC: C07K7/06
Filed: 1994-06-20
Abstract: Forbindelser med formel I, hvor R1 er OH eller OS03H; M er Met, Ahx eller Ile; G er Gly eller Sår; X er Met, Ahx, Ile, Phe eller Lys(R2); J er Asp, Asp(OBn), DAsp, MeAsp eller MeDAsp og L er Phe eller MePhe; med forskjellige forutsetninger; og farmasøytiske aksept- able derivater derav; nyttige som terapeutiske midler, spesielt for inhibisjon av foring.
Patent NO-944141-L (NO)
Title: Nye taxanderivater, deres fremstilling og medikamenter inneholdende derivatene
Inventor: BOURZAT JEAN-DOMINIQUE
IPC: A61K31/335
Filed: 1994-10-31
Abstract: Nye taxanderivater med den generelle formel (I):. der. Ar betyr arylrest,. Ri betyr et hydrogenatom, en acetylrest eller en rest. (Rog Rg betyr hydrogen, alkyl eller sanmen danner en heterocykel, n er lik 2 eller 3). R betyr alkyl, alkenyl, alkynyl, cykloalkyl, cykloalkenyl, blcykloalkyl, fenyl eller heterocyklyl.De nye produkter med den generelle formel (I) rapporteres å ha en Interessant anti-turooral virkning.Forbindelsenes fremstilling beskrives.
Patent NO-944537-L (NO)
Inventor: NORTH JANICE
IPC: A61K41/00
Filed: 1994-11-25
Abstract: Treatment with a set of porphyrin compounds using a photodynamic therapy approach is able selectively to lower elevated levels of activated leukocytes in a leukocyte population. This is particularly helpful in subjects containing such elevated levels of T-cell subsets, such as HIV-infected subjects.
Patent NO-953550-L (NO)
Inventor: BIGNELL NOEL
IPC: G01F1/66
Filed: 1995-09-08
Abstract: PCT No. PCT/AU94/00104 Sec. 371 Date Oct. 27, 1995 Sec. 102(e) Date Oct. 27, 1995 PCT Filed Mar. 7, 1994 PCT Pub. No. WO94/20821 PCT Pub. Date Sep. 15, 1997The present invention relates to a fluid flow arrangement where the effects of high order acoustic modes are suppressed in ultrasonic flow measurement. In one embodiment, ultrasonic transducers are arranged in a duct configured to carry a fluid. Ultrasonic signals between the transducers travel in a plurality of high order modes having velocities slower than a fundamental mode whose time of flight is desired to determine with accuracy. A measurement portion between the transducers is adapted to suppress the propagation of the non-fundamental modes.