baber/WOPTO huggingface dataset:
Patent AU-2020329369-A1 (AU)
Title: Chimeric antigen receptor and immune effector cell expressing chimeric antigen receptor
Inventor: SUN CHUANG
IPC: C07K19/00
Filed: 2020-08-06
Abstract: Provided are a chimeric antigen receptor capable of targeting B7-H3, a nucleic acid molecule encoding the chimeric antigen receptor, a nucleic acid construct containing the nucleic acid molecule, an immune effector cell expressing the chimeric antigen receptor, and a use thereof. The chimeric antigen receptor comprises an anti-B7-H3 binding structural domain, a hinge region, a transmembrane structural domain and a signal transduction structural domain. Further provided are a composition and a method for diagnosing, treating or preventing tumors that express B7-H3.
Patent AU-2020354360-A1 (AU)
Title: Lesion crossing shock wave catheter
Inventor: PHAN HUY
IPC: A61B17/22
Filed: 2020-09-15
Abstract: The present invention provides a catheter for treating occlusions in blood vessels. The catheter includes at least one electrode pair (222, 243) positioned inside of a flexible angioplasty balloon (280) at the distal end (200) of the catheter. In some designs, the electrode pairs are arranged in a low-profile or coplanar configuration, reducing the diameter of the distal end of the device and permitting treatment of tight and hard-to-cross occlusions. The flexible angioplasty balloon (280) has an extremely low profile and does need to be folded before insertion of the catheter into the cardiovascular system. During treatment, the balloon can be expanded a relatively small amount sufficient to immerse the electrode pairs in a conductive fluid before generating shock waves across the electrodes to treat the occlusion. The balloon can be made of material having elastomeric properties such that it returns to its original low profile configuration when it is deflated following treatment.
Patent AU-2020360407-A1 (AU)
Title: Self-sizing device for delivering a formulation to a lumen wall
Inventor: IMRAN MIR
IPC: A61M31/00
Filed: 2020-09-30
Abstract: A system is provided for delivering a therapeutic formulation into a lumen. The system includes a self-sizing device comprising an expandable component that includes at least one non-compliant section structured to resist deformation in an expanded configuration, the expandable component further including at least one hinge structured to allow deformation in an expanded configuration, the expandable component structured to bend about the hinge upon expansion to adapt to an inner circumference of a lumen independent of the inner circumference of the lumen within a selected range. The system includes the therapeutic formulation and a delivery mechanism. The self-sizing device is structured to, upon expansion of the expandable component, cause the delivery mechanism to apply a force to the therapeutic formulation, the force designed to expel the therapeutic formulation from the self-sizing device. The self-sizing device may be disposed within a capsule.
Patent AU-2020361523-A1 (AU)
Title: Container apparatus
Inventor: KICK MERRILEE
IPC: B65D51/24
Filed: 2020-10-08
Abstract: A container apparatus includes a container body and a container lid. The container body defines a first internal cavity. The container lid is attached to the container body and defines a second internal cavity. The container lid includes protrusions extending within the second internal cavity to grind solid materials.
Patent AU-2020362909-A1 (AU)
Title: Acceleration of MRI examinations
Inventor: KNOBLOCH GESINE
IPC: A61B5/00
Filed: 2020-10-05
Abstract: The invention relates to the acceleration of MRI examinations, particularly during the detection and differential diagnosis of focal liver lesions by way of dynamic contrast-enhanced magnetic resonance imaging (MRI). The invention also relates to a method, a system and a computer program product for generating MRI images, particularly of the liver.
Patent AU-2020370481-A1 (AU)
Title: Systems and devices for electroporation of cell-containing fluid
Inventor: YEO STEVEN HUEI
IPC: C12M1/42
Filed: 2020-10-23
Abstract: The present disclosure provides electroporation cartridges for single use electroporation as well as electroporation cartridges for automated batch processing, electroporation instruments and systems and methods of electroporation using these devices and systems. In some embodiments, electroporation cartridges comprise an electroporation chamber defined by an elongate body, a first electrode at a proximal end and a second electrode at a distal end of a chamber. Electroporation systems of the disclosure include one or more components including a pulse generator, compartments for placing either flow-through or single use electroporation cartridges, components for storage of cells, cooling and pre-cooling mechanisms, removably insertable modular casings having compartments for holding and arranging electroporation system and reagent components, one or more pumps for moving sample through the system, and processors and controllers.
Patent AU-2020388241-A1 (AU)
Title: Formulations with high glass transition temperatures, for laminates
Inventor: MARKOU KONSTANTINOS
IPC: C08K7/16
Filed: 2020-11-19
Abstract: The present invention relates to curable resin compositions, methods for producing cured compositions using these curable resin compositions, and to articles, in particular moldings, produced by these methods.
Patent AU-2020409844-A1 (AU)
Title: AC submarine power cable with reduced losses
Inventor: THYRVIN OLA
IPC: H01B7/282
Filed: 2020-12-18
Abstract: A static AC submarine power cable (1) configured for at least 72 kV operation comprising: a power core (3a) comprising: a conductor (5a), an insulation system (7a) surrounding the conductor (5a), and a smooth metallic water- blocking sheath (15a) surrounding the insulation system (7a), wherein the metallic water-blocking sheath (15a) comprises stainless steel.
Patent AU-2020411067-A1 (AU)
Title: Biasing device for spinal device
Inventor: ARNIN URI
IPC: A61B17/70
Filed: 2020-12-20
Abstract: A spinal device includes a rod which has a first end disposed in a housing and a second end which protrudes out of the housing through an aperture and which is movable to protrude more out of the housing or less out of the housing. A biasing device, mounted on the rod, includes a series of connected at-least partial coils. A first end of the biasing device is arranged to abut against the housing and a second end of the biasing device, opposite to the first end, is affixed to the rod.
Patent AU-2020423106-A1 (AU)
Title: Recovery of ethylene oxide from sterilization process
Inventor: DUFF JOSEPH
IPC: C07D303/04
Filed: 2020-06-22
Abstract: The invention relates to a process for the recovery and recycling of ethylene oxide (EO) after use in a sterilization process. The process involves the steps of introducing a mixed gas stream containing EO, nitrogen, oxygen, CO2, water, and a few other trace elements. The system includes integrated EO concentration sensors to determine the concentration of the EO in the gas stream. The system includes a series of compressors to pressurize the gas stream, and chillers or condensers to cool the gas stream to condense the EO out of the gas stream. The system includes temperature and pressure sensors to determine the conditions in the gas stream, and a control system that evaluates the temperature and pressure data and controls the compressors and chillers to achieve the properties to maximize the condensation of EO out of the gas stream.
Patent AU-2020437170-A1 (AU)
Title: Electronic derotation of picture-in-picture imagery
Inventor: BIRD MARCOS
IPC: H04N5/45
Filed: 2020-11-05
Abstract: Electronically derotating a picture-in-picture video source can be used to independently derotate a secondary video source separate a primary video source. A method of electronically derotating a picture-in-picture image are described herein, the method comprising processing a first image having a first image primary axis; processing a second image having a second image primary axis; derotating the second image around the second image primary axis to align the second image primary axis substantially parallel with the first image primary axis; and displaying the first image and the second image on a display.
Patent AU-2020473277-A1 (AU)
Title: Methods and systems of extended reality environment interaction based on eye motions
Inventor: AHER ANKUR ANIL
IPC: G06F3/01
Filed: 2020-12-29
Abstract: Systems and methods are described for extended reality environment interaction. An extended reality environment including an object is generated for display, and a first sensor is used to detect that a gaze has shifted from a first portion of the extended reality environment to a second portion of the extended reality environment, where the object is excluded from the first portion of the extended reality environment and included in the second portion of the extended reality environment. An indicator of the shift in the gaze is generated for display within the extended reality environment in response to detecting the gaze shift, and a voice command is detected by a second sensor while the indicator is in a vicinity of the object. In response to detecting the voice command, an action corresponding to the voice command may be executed.
Patent WO-2022000019-A1 (WO)
Inventor: HEAD RICHARD JOHN
IPC: A61K31/337
Filed: 2021-06-30
Abstract: Methods and uses of Rilpivirine and analogues thereof in the treatment and/or prevention of proliferative cell diseases and conditions are disclosed. Among the diseases and conditions that may be treated and/or prevented, are cancers characterised by Aurora A dysregulation.
Patent AU-2021202576-A1 (AU)
Title: Fenfluramine compositions and methods of preparing the same
Inventor: LONDESBROUGH DEREK
IPC: B01J23/72
Filed: 2021-04-27
Abstract: FENFLURAMINE COMPOSITIONS AND METHODS OF 
PREPARING THE SAME 
ABSTRACT 
Methods of preparing a fenfluramine active pharmaceutical ingredient are provided.  
Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile 
composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2
(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce 
a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and 
(c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with 
ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also 
provided are compositions and pharmaceutical ingredients prepared according to the subject 
methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by 
weight in total of trifluoromethyl regioisomers.  
62
Patent AU-2021203476-A1 (AU)
Title: Nested microgrid control system
Inventor: HONG JUNHO
IPC: H02J3/10
Filed: 2021-05-27
Abstract: Unique systems, methods, techniques and apparatuses of a power grid control system.  
One exemplary embodiment is a nested microgrid system comprising a first microgrid including 
a network controller, a second microgrid, a third microgrid, a first restoration path selectively 
coupled between a second portion of the first microgrid and the second microgrid, and a second 
restoration path selectively coupled between the second portion of the first microgrid and the 
third microgrid. The network controller is configured isolate the first portion of the first 
microgrid from the second portion of the first microgrid, calculate weighting factors for the first 
and second restoration paths, select the first restoration path using the first weighting factor and 
the second weighting factor, and couple the second portion of the first microgrid to the second 
microgrid using the first restoration path.  
17643664 1 (GHMatters) P112633.AU.1
Patent AU-2021206234-A1 (AU)
Title: Muscle targeting complexes and uses thereof for treating myotonic dystrophy
Inventor: SUBRAMANIAN ROMESH R
IPC: A61P9/00
Filed: 2021-01-08
Abstract: Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of a DMPK allele comprising a disease-associated-repeat. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.
Patent AU-2021209324-A1 (AU)
Title: Agricultural Fencing Technique and Fence
Inventor: OLD FRASER PATISON
IPC: E04H17/04
Filed: 2021-07-30
Abstract: A method of forming an interlaced wire fence extension using at least one wire 
(11, 12) and a multiplicity of picket extenders (21, 22, 23...) each engageable 
with a corresponding one of a multiplicity of substantially co-planar steel pickets 
5 (4) is disclosed. The method comprising the steps of 
(i) extending the at least one wire between a pair of strainer posts (10, 30) aligned 
with the star pickets so that the wire is located in a substantially vertical plane 
above the pickets, and tensioned sufficiently so as to not droop excessively, 
(ii) moving a first picket extender upwardly next to the wire so that the first 
10 picket extender lies to one side of the wire, and then moving the first picket 
extender downwardly to engage with the top of a corresponding steel picket, 
(iii) moving a second picket extender upwardly next to the wire so that the second 
picket extender lies to the other side of the wire, and then moving said second 
picket extender downwardly to engage with the top of a corresponding steel 
15 picket, and 
(iv) repeating steps (ii) and (iii) in sequence for the remaining picket extenders so 
that the odd-numbered picket extenders lie to one side of the wire, and the even 
numbered extenders lie to the other side of the wire, whereby the wire is 
interlaced or interwoven about said picket extenders. A method using two wires is 
20 also disclosed were one wire zigzags through the pickets and the second wire 
zags zigs through the pickets.  
FILE REF: 5514BX-AU 10
CIOA 
0c
Patent AU-2021225786-A1 (AU)
Title: Electrosurgical apparatus with flexible shaft
Inventor: ROMAN SHAWN D
IPC: A61B18/04
Filed: 2021-02-20
Abstract: An electrosurgical apparatus is provided including a connector, a flexible shaft, and a distal tip. The connector may further be coupled to an electrosurgical generator and gas supply. The distal tip of the electrosurgical apparatus may be grasped by a grasping tool, such that the orientation and position of the distal tip relative to the shaft may be manipulated to achieve a plurality of positions. The electrosurgical apparatus provides electrosurgical energy and inert gas to an electrode within the distal tip of the electrosurgical apparatus to generate a plasma beam. In one aspect, the distal tip is configured as a sheath that is extendable and retractable over the electrode to expose the electrode when the sheath is in a first position and conceal or cover the electrode when the sheath is in a second position.
Patent AU-2021240106-A1 (AU)
Title: Engineered transferrin receptor binding polypeptides
Inventor: CHEN XIAOCHENG
IPC: C07K14/79
Filed: 2021-09-27
Abstract: OF THE DISCLOSURE 
Provided herein are polypeptides that bind to a transferrin receptor, methods of 
generating such polypeptides, and methods of using the polypeptides to target a composition 
to a transferrin receptor-expressing cell.
Patent AU-2021266857-A1 (AU)
Title: Method for producing a molding compound
Inventor: SCHNEIDER DENISE
IPC: C08J3/18
Filed: 2021-04-23
Abstract: Method for producing molding compounds, at least consisting of a binder and a softener, the binder and the softener being in the form of plastisols, the plastisol being essentially composed of PVC and softener, characterized in that the method of production has the following steps: in a first step, mixing the PVC powder and the amount of softener with optionally other admixtures and/or additives and carrying out the mixing process at a mixing temperature of approximately 55 to 70°C.
Patent AU-2021274841-A1 (AU)
Title: Aerosol-generating article comprising a flame-retardant
Inventor: PAPAKYRILLOU STEFANOS
IPC: A24D1/20
Filed: 2021-05-18
Abstract: There is provided an aerosol-generating article (10; 110) for producing an inhalable aerosol upon heating. The aerosol-generating article (10; 110) comprises: a rod (12) of aerosol-generating substrate; a downstream section (14; 114) at a location downstream of the rod (12) of aerosol-generating substrate; and a wrapper (70) circumscribing at least the rod (12) of aerosol-generating substrate. A density of the aerosol-generating substrate is greater than about 300 milligrams per cubic centimetre, and the wrapper (70) comprises a flame retardant composition comprising one or more flame retardant compounds.
Patent AU-2021284378-A1 (AU)
Title: Zonal and targeted methods and uses for treating a migraine disorder
Inventor: BINDER WILLIAM J
IPC: A61K35/74
Filed: 2021-06-03
Abstract: The present specification discloses methods and uses for treating a migraine disorder. The disclosed method comprising extramuscularly administering a Botulinum toxin to an individual in one of more areas of a fronto-fascial layer located in a frontal head region of the individual, one of more areas of a temporoparietal-fascial layer located in a temporal head region of the individual, and one or more areas of an occipito-fascial layer located in an occipital head region of the individual. The disclosed methods and uses further comprise extramuscularly administering a Botulinum toxin to one or more nerve exit points, one or more subcutaneous locations in the head and neck as well as one or more sites of an epicranial aponeurosis and/or intramuscularly administration to one or more locations within the left /right Splenius Capitus, the left/right Masseter, the left/right Trapezius muscles, or any combination thereof.
Patent AU-2021298186-A1 (AU)
Title: Pyruvate Kinase Deficiency (PKD) gene editing treatment method
Inventor: SEGOVIA SANZ JOSÉ CARLOS
IPC: A61K48/00
Filed: 2021-06-28
Abstract: The present invention relates to the treatment of Pyruvate Kinase Deficiency (PKD) using the Clustered- Regularly Interspaced Short Palindromic Repeats (CRISPR) system. This technology offers the possibility to design an improved single guide RNA (sgRNA), in particular, an improved crRNA to be associated with tracrRNA, which is incorporated into a CRISPR-associated protein (Cas9) to recognize and induce DNA double-strand breaks at a specific target location. DNA double-strand breaks will be repaired by homologous recombination (HR) in the presence of a donor sequence for PKLR gene repair.
Patent AU-2021325793-A1 (AU)
Title: Positive pressure breathing circuit
Inventor: LOVE DAVID JOHN
IPC: A61M16/08
Filed: 2021-10-12
Abstract: The disclosure relates to a positive pressure breathing circuit and a method for ventilating a patient. The breathing circuit can be used in any type of pressurized breathing therapy including, for example, continuous positive air(way) pressure (CPAP) therapy and bilevel positive air pressure therapy where the inspiratory and expiratory pressures differ. The positive pressure breathing circuit comprises an inspiratory member including a distal portion connectable to a first gas and a proximal portion connectable to second gas wherein the inspiratory member is configured to store a volume of second gas. The inspiratory member further comprises a first non-return valve located proximally to the second gas entering the inspiratory member to inhibit the exhaled gases from entering the inspiratory member. The breathing circuit also comprises an expiratory member and second non-return valve to inhibit exhaled gases from re-entering the patient interface.
Patent AU-2021344320-A1 (AU)
Title: Compressible shunt implant
Inventor: MURRAY DANIEL JAMES
IPC: A61B17/11
Filed: 2021-09-09
Abstract: A medical implant comprises a central flow portion having a first network of struts forming two or more cells, a first set of anchoring arms, and a second set of anchoring arms. The two or more cells are arranged linearly and extend from the first set of anchoring arms to the second set of anchoring arms.
Patent AU-2021346233-A1 (AU)
Title: MDM2 inhibitors for use in the treatment or prevention of hematologic neoplasm relapse after hematopoietic cell transplantation
Inventor: ZEISER ROBERT
IPC: A61K31/40
Filed: 2021-09-21
Abstract: The invention relates to a mouse double minute 2 (MDM2) inhibitor for use in the treatment and/or prevention of a hematologic neoplasm relapse after hematopoietic cell transplantation (HCT) in a patient. In embodiments, the hematologic neoplasm is a leukaemia, preferably acute myeloid leukaemia (AML). Preferably, the patient received an allogeneic T cell transplantation, either together with the HCT and/or after HCT, such as at the time point of MDM2 administration. Furthermore, the invention relates to a pharmaceutical composition comprising a MDM2 inhibitor and an exportin 1 (XPO-1) inhibitor for use in the treatment and/or prevention of a hematologic neoplasm relapse after hematopoietic cell transplantation (HCT) in a patient according to any of the preceding claims.
Patent AU-2021361270-A1 (AU)
Title: Tool for inter operative use during direct anterior approach total hip arthroplasty and related methods
Inventor: FELL PATRICK MCDOUGALL
IPC: A61B17/16
Filed: 2021-10-15
Abstract: A surgical guide tool to visually aid in setting of the desired leg length and femoral offset of a patient inter-operatively during direct anterior approach arthroplasty. The tool comprises a femur contact member able to make at least two point contact with the femur and a pelvis contact member able to make at least one point contact with the pelvis. The femur contact member and the pelvis contact member are coupled together. They can move relative to each other to allow them to contact the femur and pelvis respectively. They can also be made to lock relative to each other to be used as a guide for setting the leg length and femoral offset provided for by the hip prosthetic.
Patent AU-2021368674-A1 (AU)
Title: Arthroscopic resection probe
Inventor: LYNN CHRISTOPHER J
IPC: A61B18/14
Filed: 2021-10-29
Abstract: A combination arthroscopic tissue resecting probe is disclosed, including an elongated shaft with an outer, electrically conductive sleeve and an inner sleeve. Each sleeve has a distal region with a cutting window, the inner sleeve being rotatable to cut tissue. An outer surface of the outer sleeve distal region carries a ceramic body (580) and an electrode (570). The active electrode (570) defining two portions, angularly offset from each other, the two portions including a first portion (571) that extends circumferentially and axially along the tubular distal end and a second portion (578) that extends from a distal end of the first portion and across the tubular distal end, the second portion having at least one flange (595) configured to engage a notch (581) in the electrically insulative spacer (580) to resist separation of the active electrode from the electrically insulative spacer (580). The electrode, the ceramic body and the outer sleeve each define a first aspiration (572, 586, 512) opening for aspirating fluid ablation byproducts therethrough into an interior of the shaft. Various methods of improved electrode attachment are disclosed, that provides a low profile probe distal end, while maintaining electrosurgical functionality.
Patent AU-2021378005-A1 (AU)
Title: Amino-combretastatin derivative and use thereof
Inventor: WANG JIANPING
IPC: C07C231/02
Filed: 2021-11-02
Abstract: Disclosed is an amino-combretastatin derivative, and in particular a compound represented by general formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof, or a hydrate of the pharmaceutically acceptable salt thereof, a solvate thereof or a solvate of the pharmaceutically acceptable salt thereof, and an isomer thereof. In general formula (I), R