Patent EP-3991801-A1 (EP)
Inventor: BARASNEVICIUTE KAROLINA
IPC: A61K8/9789
Filed: 2020-11-03
Abstract: REFERENCES CITED1. Dastmalchi K., Dorman H.J.D., Kosar M., Hiltunen R. (2007) Chemical composition and in vitro antioxidant evaluation of a water-soluble Moldavian balm (Dracocephalum moldavica L.) extract. LWT Food Sci Technol 40:239-248.2. Povilaityte' V, Cuvelier ME, Berset C (2001) Antioxidant properties of Moldavian dragonhead (Dracocephalum moldavica L.). J Food Lipids 8:45-64.3. Higuera-Ciapara, I.; Félix-Valenzuela, L.; Goycoolea, F.M. Astaxanthin: A review of its chemistry and applications. Crit. Rev. Food Sci. Nutr. 2006, 46, 185-196.4. Davinelli, S., Nielsen, M., & Scapagnini, G. (2018). Astaxanthin in skin health, repair, & disease: a comprehensive review. Nutrients., 10, 521-533.5. Silva, T.H.; Alves, A.; Ferreira, B.; Oliveira, J.M.; Reys, L.; Ferreira, R.; Sousa, R.; Silva, S.; Mano, J.; Reis, R. Materials of marine origin: A review on polymers and ceramics of biomedical interest. Int. Mater. Rev. 2012, 57, 276-306.6. De Luca C., Mikhal'chik E.V., Suprun M.V., et al. Skin antiaging and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. Oxid Med Cell Longev. 2016; 2016:4389410.7. Han X., Parker T.L. Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Mode. Phytother. Res. 2017; 31(7):1034-1038.8. Takasao N., Tsuji-Naito K., Ishikura S., et al. Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts. J Agric Food Chem 2012; 60(5):1193-200.9. Borkow G. Using Copper to Improve the Well-Being of the Skin. Current Chemical Biology, 2014, 8, 89-102.10. Lin C.C., Lu J.M., Yang J.J. et al. Anti-inflammatory and radical scavenge effects of Arctium lappa. Am. J. Chin. Med. 1996; 24:127-37.11. Holetz F.B., Pessini G.L., Sanches N.R., et al. Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Mem Inst Oswaldo Cruz 2002; 97:1027-31.12. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.13. Dreno B., Trossaert M., Boiteau H.L., Litoux P. Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients. Acta Derm Venereol 1992; 72:250-2.14. Michaelsson G., Ljunghall K. Patients with dermatitis herpetiformis, acne, psoriasis and Darier's disease have low epidermal zinc concentrations. Acta Derm Venereol 1990; 70:304-8.15. Myllyharju J. (2005) Intracellular post-translational modifications of collagens. Top. Curr. Chem. 247: 115-247.16. Prussick R., Ali M.A., Rosenthal D., Guyatt G. The protective effect of vitamin E on the hemolysis associated with dapsone treatment in patients with dermatitis herpetiformis. Arch Dermatol. 1992; 128:210-3.17. Mukhopadhyay D., Das M.K., Dhar S., Mukho-padhyay M. Multiple carboxylase deficiency (late onset) due to deficiency of biotinidase. Indian J Dermatol 2014; 59: 502-504.18. Aguirre-Cruz G., Leon-Lopez A., Cruz-Gomez V., Jiménez-Alvarado R., Aguirre-Alvarez G. Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation. Antioxidants (Basel). 2020; 9(2):181. Published 2020 Feb 22. doi:10.3390/antiox9020181.19. Stephens T.J., Sigler M.L., Hino P.D., Moigne A.L., Dispensa L. A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin. J Clin Aesthet Dermatol. 2016; 9(4):25-32.20. Verma K.C., Saini A.S., Dhamija S.K. Oral zinc therapy in acne vulgaris: a double blind trial. Acta Derm. Venereol. 1980; 60(4): 337-340.21. Michaëlsson G., Juhlin L., Ljunghall K. A double-blind study of the effect of zinc and oxytetracycline in acne vulgaris. Br. J. Dermatol. 1977; 97(5):561-566. doi:10.1111/j.1365-2133.1977.tb14136.22. Tominaga K., Hongo N., Fujishita M., Takahashi Y., Adachi Y. Protective effects of astaxanthin on skin deterioration. J. Clin. Biochem. Nutr. 2017; 61(1):33-39. doi:10.3164/jcbn.17-35.The present invention relates to the composition of food supplement comprising balanced combination of nutritional materials useful in maintaining normal skin condition and acting sinergistically that has the unique research-proven anti-aging effect with antioxidant effects. The composition comprises extract of Moldavian dragonhead (Dracocephalum moldavica), astaxanthin, common grapevines (Vitis vinifera) seed extract, extract of roots of greater burdock (Arctium lappa), biotin, cinnamon, vitamin C from acerola cherry (Malphigia glabra), as well as other vitamins and minerals which being in complex complement each other. The ingredients of food supplement composition are in 100 % active materials of plant origin, wihout any artificial additives, binders or excipients. The composition of the food supplement is administered taking into account the changing needs of the age-related skin.