baber/WOPTO huggingface dataset:
Patent WO-2021141838-A1 (WO)
Title: Surgical instrument
Inventor: NALLAKRISHNAN RAVI
IPC: A61B17/32
Filed: 2021-01-04
Abstract: A surgical blade (10) for being combined with an elongate handle (50) to form a cutting instrument for ophthalmic surgery includes a proximal portion (12) for being attached to the handle (12), an operative, distal portion (14), and a central portion (20) extending therebetween. The central portion (20) having a trapezoidal configuration that tapers radially inwardly from the proximal portion (12) to the distal portion and having a pair of sharpened lateral edges (21, 22). The distal portion (14) includes a first tapered section (23) defining a pair of sharpened lateral edges (24, 25) and extending from the central portion (20) to a substantially straight section (26) having a pair of sharpened lateral edges (27, 28). The substantially straight section (26) extends from the first tapered section (23) to a second tapered section (30) having a pair of sharpened lateral edges (32, 33) and terminating at a pointed tip (36).
Patent WO-2021146159-A1 (WO)
Title: Force sensor apparatus and a method of assembling the same
Inventor: FORTGENS LAURENS C
IPC: G01L1/22
Filed: 2021-01-12
Abstract: In a particular embodiment, a force sensor apparatus is disclosed that includes a force-compliant element that deforms in response to forces applied to the force sensor apparatus. The apparatus also includes a sensing element coupled to the force-compliant element and is configured to generate a signal indicating the degree that the force-compliant element deforms in response to the applications of forces to the force sensor apparatus. In this embodiment, the apparatus also includes a printed circuit board configured to receive the signal from the sensing element and a support structure having a surface on which the printed circuit board is coupled. The support structure has an outer rim that is attached to the force-compliant element. The apparatus also includes a sensor housing that covers the printed circuit board. The sensor housing has an outer rim attached to the force-compliant element.
Patent WO-2022031318-A1 (WO)
Title: Floor covering
Inventor: HIGGINS KENNETH
IPC: A47G27/04
Filed: 2021-01-12
Abstract: A method of making a floor covering including a tufted textile substrate and a reinforcement backing system. The backing system includes adhesive layers which are conditioned to include voids, A layer of reinforcement fibers is positioned between the adhesive layers. After drying, the layers of adhesive and reinforcement fibers are compressed to collapse the voids in the layers of adhesive and to encapsulate the reinforcement fibers. The layer of reinforcement fibers is also moved toward the primary backing substrate and into engagement with the ends of the tufts.
Patent WO-2021146258-A1 (WO)
Title: Combination therapy for cancer
Inventor: KARIN MICHAEL
IPC: A61K45/06
Filed: 2021-01-13
Abstract: Provided herein are methods and compositions for treating cancer through a combination of an inhibitor of macropinocytosis upregulation and an autophagy inhibitor. Also provided are methods and compositions for inducing cell death of cancer cells, and transgenic animal models regarding same.
Patent WO-2021155227-A1 (WO)
Title: Indazole derivatives as cannabanoid receptor partial agonists
Inventor: AMATO GEORGE
IPC: A61K31/454
Filed: 2021-01-29
Abstract: The present disclosure includes peripheral partial agonists of one or more CB receptors, including modulation of CB1, both with and without CB2 selectivity. The compounds of the present disclosure may be useful in the treatment of diseases and disorders mediated by a CB-signaling pathway, including but not limited to pain, gastrointestinal disorders, metabolic disorders, and liver disorders, such as alcoholic steatohepatitis or nonalcoholic steatohepatitis (NASH),
Patent WO-2021158642-A1 (WO)
Title: System and method for measuring distorted illumination patterns and correcting image artifacts in structured illumination imaging
Inventor: PENG LEILEI
IPC: G06F17/16
Filed: 2021-02-03
Abstract: A method for measuring distorted illumination patterns and correcting image artifacts in structured illumination microscopy. The method includes the steps of generating an illumination pattern by interfering multiple beams, modulating a scanning speed or an intensity of a scanning laser, or projecting a mask onto an object; taking multiple exposures of the object with the illumination pattern shifting in phase; and applying Fourier transform to the multiple exposures to produce multiple raw images. Thereafter, the multiple raw images are used to form and then solve a linear equation set to obtain multiple portions of a Fourier space image of the object. A circular 2-D low pass filter and a Fourier Transform are then applied to the portions. A pattern distortion phase map is calculated and then corrected by making a coefficient matrix of the linear equation set varying in phase, which is solved in the spatial domain.
Patent WO-2021159070-A1 (WO)
Title: Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions
Inventor: MILLET GARY
IPC: A23L33/10
Filed: 2021-02-08
Abstract: A ketogenic R-beta-hydroxybutyrate mixed salt-acid composition includes enantiomerically pure R-beta-hydroxybutyric acid and one or more enantiomerically pure R-beta-hydroxybutyrate salts. The R-beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. The enantiomerically pure R-beta-hydroxybutyrate salt(s) are more slowly absorbed and utilized by the body and can provide one or more electrolytes. Compositions for increasing ketone body level in a subject may contain a dietetically or pharmaceutically acceptable carrier and an R-beta-hydroxybutyrate mixed salt-acid composition. The composition contains less than 100% by molar equivalents of total enantiomerically pure R-beta-hydroxybutyrate salts and more than 0% by molar equivalents of enantiomerically pure R-beta-hydroxybutyric acid.
Patent WO-2021168066-A1 (WO)
Title: Method and machine for dispensing an individual formulation of a beverage
Inventor: HALL DOUGLAS
IPC: B67D1/06
Filed: 2021-02-18
Abstract: The present invention is a method for developing and providing a personalized distilled spirit, or other beverage, to a user who who responds to a collection of stimulus in the form of taste samples, smell samples, written, and/ or visual representations. The user's responses to the stimulus may be compared to expert responses in a database to create a recommended recipe resulting in one or more customized product samples being either physical products or written/visual responses in the form of tasting notes or a flavor map, for example. The user can then modify their customized spirit, repeating the process as many times as they wish and then submit for the production and purchase of the recipe based on an array of spirits or other beverages that is then combined using a blending machine.
Patent WO-2021168160-A1 (WO)
Title: Real time remote video collaboration
Inventor: CYRELL ALEX
IPC: H04L29/06
Filed: 2021-02-18
Abstract: Described are systems and methods that enable secure real time communication ("RTC") sessions that may be used, for example, for editing and movie production. Client devices may interact with an RTC management system to collaborate on different files retained on the different client devices, without the files having to be uploaded from the client device on which it is stored. In addition, on-going multifactor authentication may be performed for each client device of an RTC session during the RTC session and/or video authentication may be used to grant access into an RTC session. Still further, to improve the quality of the exchanged video information and to reduce transmission requirements, in response to detection of events, such as a pause event, a high resolution image of a paused video may be generated and sent for presentation on the display of each client device, instead of continuing to stream a paused video.
Patent WO-2021178248-A1 (WO)
Inventor: XU HUILIN
IPC: H04L5/00
Filed: 2021-02-26
Abstract: Methods, systems, and devices for wireless communications are described. For example, a method for wireless communications at a wireless device may include determining a rate matching configuration for a first channel (e.g., an uplink channel) associated with a second channel (e.g., a downlink channel). A wireless device may determine rate matching resources of an uplink channel based on the rate matching configuration. The wireless device may determine rate matching resources of a downlink channel based on the rate matching configuration. The wireless device may transmit a first message on the uplink channel or the downlink channel, respectively, where the transmitted channel includes the rate matching resources. The wireless device may receive a reference signal on one or more resources of the downlink channel or the uplink channel, respectively, where the one or more resources of the respective channel correspond to the rate matching resources on the transmitted channel.
Patent WO-2021178265-A1 (WO)
Inventor: LI JIASHU
IPC: A61N1/36
Filed: 2021-03-01
Abstract: This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation therapy. In some examples, a medical device includes stimulation generation circuitry configured to deliver a first stimulation pulse to a patient, sensing circuitry configured to sense the first stimulation pulse, and processing circuitry. The processing circuitry is configured to determine that a value of a characteristic of the sensed first stimulation pulse exceeds a target stimulation pulse value and responsive to determining that the value of the characteristic of the sensed first stimulation pulse exceeds the target stimulation pulse value, change a first value of a parameter to a second value of the parameter that at least partially defines a second stimulation pulse deliverable by the stimulation generation circuitry after the first stimulation pulse was sensed.
Patent WO-2021178352-A1 (WO)
Title: Élément de fixation à filetage interne à caractéristique de couple dominant
Inventor: JOHNSON LAWRENCE
IPC: F16B37/00
Filed: 2021-03-02
Abstract: Un élément de fixation fileté à caractéristique de couple dominant et un procédé de formation de ce dernier comportent un cylindre à axe longitudinal. Le cylindre comporte une pluralité de filets internes, chaque filet interne comportant une surface orientée vers l'avant et une surface orientée vers l'arrière. Un premier angle, entre la surface orientée vers l'arrière et un premier axe latéral perpendiculaire à l'axe longitudinal, est compris entre 20° et 40°. Un second angle, entre la surface orientée vers l'avant et la surface tournée vers l'arrière, est compris entre 80° et 100°.
Patent WO-2021195397-A1 (WO)
Inventor: BAKALE ROGER
IPC: C07D271/06
Filed: 2021-03-25
Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein R is as defined herein. Such compounds serve as modulators of the sphingosine-1-phosphate receptor, and have utility for treatment of a malcondition for which activation of this receptor is medically indicated.
Patent WO-2021195548-A1 (WO)
Title: Composés d'oléoyléthanolamide
Inventor: SILVER DAVID LAWRENCE
IPC: A61P35/00
Filed: 2021-03-26
Abstract: La présente invention concerne des composés d'oléoyléthanolamide utiles pour traiter une maladie ou un trouble chez un sujet en ayant besoin. L'invention concerne également des compositions pharmaceutiques comprenant les composés et des méthodes de traitement de maladies ou de troubles.
Patent WO-2021207334-A1 (WO)
Inventor: CROW KIELAN C
IPC: G03B17/55
Filed: 2021-04-07
Abstract: Un dispositif de capture d'image comprend un premier composant qui est conçu pour fournir de l'énergie thermique. Un dissipateur thermique est situé à une certaine distance du premier composant, et un second composant est positionné entre le premier composant et le dissipateur thermique. Un conducteur entre en contact avec le premier composant et le dissipateur thermique, et le conducteur s'étend du premier composant le long des côtés du second composant jusqu'au dissipateur thermique.
Patent WO-2022159133-A1 (WO)
Inventor: DE CALLAFON RAYMOND
IPC: H02J3/32
Filed: 2021-05-27
Abstract: Un programme de flux d'énergie d'un groupe est déterminé par calcul de la sensibilité des limites d'échange d'énergie nette. Chaque groupe comprend une section différente du système d'alimentation. Le groupe fournit à un autre groupe le programme de flux d'énergie et les limites d'échange d'énergie nette pour la détermination d'un second programme de flux d'énergie par un autre groupe sur la base de bornes d'échange d'énergie nette collectives, d'une alimentation électrique de prévision de la pluralité de groupes et d'un programme de demande d'énergie de prévision. Les groupes sont agencés hiérarchiquement de telle sorte que l'autre groupe soit plus élevé dans une hiérarchie que le groupe. Le groupe reçoit en provenance de l'autre groupe le second programme de flux d'énergie. Le premier programme de flux d'énergie est ajusté localement à l'intérieur du groupe sur la base du second programme de flux d'énergie et des limites d'échange d'énergie nette du groupe. La sortie d'énergie du groupe est commandée à l'aide du premier programme de flux d'énergie ajusté.
Patent WO-2021243071-A1 (WO)
Title: Recyclable laminated polyolefin-based film structures
Inventor: JONES ALEXANDER
IPC: B32B27/32
Filed: 2021-05-27
Abstract: A recyclable, laminated polyolefin-based film structure comprises two or more film plies laminated to each other. Each of the laminated film plies comprises one or more polyolefin-based films. The film structure has an energy-cured coating layer disposed on the outermost outward facing surface of the film structure and a printed ink layer on an interior surface of one of the polyolefin-based polyolefin layers. In certain embodiments, the outermost surface of the laminated polyolefin-based film structure has a melting temperature which is at least 100 degrees Celsius, and more preferably 180 degrees Celsius, higher than a melting temperature of the innermost surface of the laminated polyolefin-based film structure.
Patent WO-2021243341-A1 (WO)
Title: A dynamic mixing and delivery system for mixing a therapeutic agent in an injector or autoinjector
Inventor: CHAGNON JEFFREY THOMAS
IPC: A61J1/22
Filed: 2021-06-01
Abstract: A mixing device configured to hold two containers, each having a separate medicament component disposed therein. A fluidic channel is provided that upon creating fluidic communication with each container once seals about each container are opened. Then a transfer mechanism can transfer the medicament components from one container to the other container until ready to be delivered or transferred through the fluidic channel through a delivery assembly.
Patent WO-2021252299-A1 (WO)
Title: Cooling jacket assembly and manufacturing methods thereof
Inventor: BOWMAN JACOB
IPC: H01M50/20
Filed: 2021-06-04
Abstract: A cooling jacket assembly includes an inner housing and an outer housing. The inner housing is disposed within the outer housing. The inner housing and the outer housing define fluid channels therebetween. The inner housing is configured to receive a cell array therein. The inner housing is coupled to the outer housing. The cooling jacket assembly is configured to transfer heat from a heat transfer fluid through the inner housing to the cell array.
Patent WO-2022035552-A1 (WO)
Inventor: SAID ALY
IPC: C04B35/645
Filed: 2021-07-15
Abstract: Des modes de réalisation concernent l'utilisation d'une solution présentant une faible molarité pour former un mélange avec un composé céramique qui facilitera la formation d'un comprimé céramique fritté présentant une formation de limite de grain, une faible porosité, une résistance adéquate à la compression et une dureté adéquate pour être utilisé en tant que bloc préfabriqué 108 pour le ciment.
Patent WO-2022026222-A1 (WO)
Inventor: CUNNINGHAM DAVID
IPC: H05B45/3577
Filed: 2021-07-16
Abstract: The disclosed invention is embodied in an improved LED-based lighting fixture for projecting a beam of light having a substantially uniform intensity, rotationally, and a selectable, substantially uniform chromaticity. The lighting fixture includes (1) a concave reflector having circumferential facets, a focal region, an aperture, and a central opening; and (2) a light source assembly including two or more groups of LEDs mounted at the forward end of an elongated, thermally conductive support. The light source assembly is mounted relative to the reflector with the elongated support's longitudinal axis aligned with the reflector's longitudinal axis and with the groups of LEDs located at or near the reflector's focal region. Each of the two or more groups of LEDs includes a plurality of LEDs arranged in two or more columns substantially parallel with the light source axis, with each column including only LEDs configured to emit light in a limited range of the visible spectrum and having the same distinct dominant wavelength, and with each group of LEDs including LEDs configured to emit light in two or more dominant wavelengths. The two or more groups of LEDs are configured to cooperate with the faceted concave reflector to project a beam of light having a selectable, substantially uniform chromaticity.
Patent WO-2022020450-A1 (WO)
Title: Methods for combinatorial cancer treatment targeting cancer robustness
Inventor: Chen sheng-hong
IPC: G16B5/00
Filed: 2021-07-21
Abstract: A method for treating a tumor by first determining a type of cancer cell in a tumor sample from a subject, followed by identification in a database a first gene and a second gene that form a compensatory pair in the type of cancer cell, the compensatory pair having a compensatory score (C-score) of at least 0.25, and administration of a first agent that inhibits activity of the first gene and a second agent that inhibits activity of the second gene. Also disclosed is a tumor-treating method that includes determining a C-score-based synthetic lethality score for each of a plurality of genes expressed in cancer cells of the tumor that correspond to a compensatory gene identified among a plurality of compensated gene/compensatory gene pairs in a database. A compensatory pair having a synthetic lethality score of at least -2 is identified from among the plurality of compensatory pairs, and the tumor is treated with two agents that each inhibit a different member of the compensatory pair.
Patent WO-2022026304-A1 (WO)
Inventor: LUBINER DANIEL
IPC: G09F9/305
Filed: 2021-07-23
Abstract: The disclosed device is useful in the instruction and practice of braille. Combined with a computer or smartphone app, the device has application to assist the vision impaired with learning of braille and in the creation of art in the classroom and in remote settings.
Patent WO-2022040141-A1 (WO)
Inventor: TANG ZHIWEN
IPC: A61K31/16
Filed: 2021-08-17
Abstract: The present invention provides sustained release formulations comprising one or more active pharmaceutical ingredient(s); at least one biocompatible polymer excipient; and at least one biocompatible solvent, methods for preparing the sustained release formulations, and methods for treating localized pain in a subject in need thereof.
Patent WO-2022046837-A1 (WO)
Inventor: FRAGALA JOSEPH S
IPC: H01J9/24
Filed: 2021-08-25
Abstract: A method for producing a radiation window includes patterning a photo resist structure onto a double-sided silicon wafer, plasma etching the silicon wafer to create an etched silicon wafer having a silicon supporting structure etched upon a first side of the double-sided silicon wafer, applying a silicon nitride thin film to the etched silicon wafer, patterning a photo resist structure and plasma etching a second side of the double-sided silicon wafer to create an initial window in the silicon nitride thin film, and wet etching the second side of the double-sided silicon wafer to release the silicon nitride thin film and supporting structure from the portion of the double-sided silicon wafer defined by the initial window.
Patent WO-2022047051-A1 (WO)
Title: Utilisation d'un composé inhibiteur de dhodh en polythérapie anticancéreuse
Inventor: COCO JOHN
IPC: A61K31/4192
Filed: 2021-08-26
Abstract: L'invention concerne un procédé de traitement de lymphomes à l'aide d'un agent anticancéreux et d'une thérapie anticancéreuse, le premier agent anticancéreux étant représenté par la Formule (I) ou un sel pharmaceutiquement acceptable de celui-ci.
Patent WO-2022060878-A1 (WO)
Title: Methods for treating prostate cancer
Inventor: KOUROS-MEHR HOSEIN
IPC: C07K16/30
Filed: 2021-09-15
Abstract: The present invention relates to treatment methods for prostate cancer using bispecific T-cell engaging molecules that specifically bind to human prostate-specific membrane antigen (PSMA) and human CD3. In particular, the present invention relates to methods for treating prostate cancer, including metastatic castration-resistant prostate cancer, in a patient in need thereof comprising administering to the patient an initiation cycle and at least one maintenance cycle of a PSMA x CD3 bispecific T-cell engaging molecule, wherein each initiation cycle and maintenance cycle comprises administering the bispecific T-cell engaging molecule according to specific dosage regimens. Pharmaceutical compositions comprising the bispecific T-cell engaging molecule for use in the methods are also disclosed.
Patent WO-2022066801-A1 (WO)
Title: Combined heat and power source having outer layer comprising cork
Inventor: THOMAS SCOTT RICHARD
IPC: H02J7/00
Filed: 2021-09-22
Abstract: Portable electronic devices having an outer layer comprising cork. Such portable electronic devices are portable, compact, and relatively lightweight. The outer layer comprising cork provides improvements in functional performance and ergonomic benefits as compared to hand warmers having polymer or metal outer layers. The portable combined hand warmer and power bank with an outer layer comprising cork exhibits improvements in heat retention, heat distribution, and limited heat transfer to the initial touch. The outer layer comprising cork is comfortable and relatively soft and grippy as compared to the plastic or metallic outer layers of conventional hand warmers. The portable electronic device having the unique outer layer comprising cork also repels and wicks moisture as compared to other hand warmers having plastic and/or metallic outer layers. The outer layer comprising cork can also be relatively anti -microbial and germ resistant.
Patent WO-2022072671-A1 (WO)
Inventor: MURPHY ANDREW J
IPC: C07K14/47
Filed: 2021-09-30
Abstract: Disclosed herein are genetically modified rodent animals comprising in their genome a nucleic acid which comprises a nucleotide sequence encoding a human CR1 polypeptide, wherein the rodent animals display a human-like expression of the human CR1 polypeptide. Also disclosed herein are isolated rodent cells including rodent embryonic stem cells, and rodent tissues. Further disclosed are nucleic acid vectors and methods for making the genetically modified rodent animals, as well as methods of using such genetically modified rodent animals for screening and testing candidate compounds.