baber/WOPTO huggingface dataset:
Patent CA-2218096-A1 (CA)
Title: New arylglycinamide derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds
Inventor: SPECK GEORG
IPC: A61P43/00
Filed: 1996-04-11
Abstract: The invention relates to new arylglycinamide derivatives of general formula I   (see formula I) and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound form a ring of the formula (see formula II) wherein p is 2 or 3 and X denotes oxygen, N(CH2)n R6 or CR7R8, and R3, R4, R5, R6, R7, R8, Ar and n have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
Patent CA-2221986-A1 (CA)
Inventor: SEUBERT PETER A
IPC: A61P25/28
Filed: 1996-06-07
Abstract: L'invention concerne la construction de modèles animaux transgéniques pour tester d'éventuels traitements de la maladie d'Alzheimer. Ces modèles se caractérisent par une pathologie similaire à celle observée dans la maladie d'Alzheimer, fondée sur l'expression des trois formes de la protéine précurseur de .beta.-amyloïde (APP), APP695, APP751 et APP770, de même que diverses mutations ponctuelles fondées sur des mutations se produisant naturellement, telles que les mutations au niveau de l'aminoacide 717 de la maladie d'Alzheimer familiale (FAD) de type London et Indiana, les mutations prédites du gène d'APP et les formes tronquées d'APP contenant la région A.beta.. Les produits de recombinaison génique d'APP sont obtenus à l'aide du promoteur génique de la chaîne du facteur B de croissance dérivé de plaquettes humaines (PDGF-B) ou d'autres promoteurs aptes à exprimer l'A.beta. ou des formes mutantes d'APP à un niveau élevé dans le tissu cérébral d'animaux transgéniques. Des cellules animales peuvent être isolées d'animaux transgéniques ou préparés à l'aide des mêmes produits de recombinaison avec des techniques standard, telles que la lipofection ou l'électroporation. Les animaux transgéniques ou les cellules animales sont utilisés pour examiner les composés qui modifient l'évolution pathologique de la maladie d'Alzheimer, qui peut être mesurée par les effets sur la quantité d'APP et de peptide de .beta.-amyloïde, la neuropathologie et les modifications comportementales.
Patent CA-2222239-A1 (CA)
Title: A method of crosslinking amino acid-containing polymers using photoactivatable chemical cross-linkers
Inventor: KENNEY M CRISTINA
IPC: G03F7/038
Filed: 1996-05-07
Abstract: A method for molecularly cross-linking amino acid-containing polymers by photoactivating chemical cross-linkers which have been combined with the polymers. Collagen cross-linked by this method can be used as a bioadhesive for sutureless closures of the skin and eye or as a superhydrated material for contact lenses, moist bandage contact lens, lens or corneal implant material, or as a drug delivery mechanism.
Patent CA-2222534-A1 (CA)
Title: In vitro packaging of adeno-associated virus dna
Inventor: MUZYCZKA NICHOLAS
IPC: C12N15/09
Filed: 1996-06-05
Abstract: A method for in vitro packaging of adeno-associated viral particles is described. The procedure involves the preparation of cell-free extracts containing all the essential components for packaging. Homogeneous purified substrate DNA for packaging may be prepared separately. The in vitro packaged AAV particles are useful in transduction of mammalian cells and for gene therapy in animals. In one described method, the DNA packaged into AAV particles is not limited by the size constraints characteristic of in vivo packaged AAV particles.
Patent CA-2223153-A1 (CA)
Title: Regulation of eating behavior
Inventor: MARATOS-FLIER ELEFTHERIA
IPC: C12N5/10
Filed: 1996-06-05
Abstract: MCH and analogs thereof in the regulation of eating and weight.
Patent CA-2223551-A1 (CA)
Title: Benzimidazole compounds
Inventor: MANO TAKASHI
IPC: A61K31/42
Filed: 1997-12-04
Abstract: This invention provides a compound of the following formula:   (see formula I) and the pharmaceutically acceptable salts thereof wherein Z is phenyl, C3-8 cycloalkyl, C4-8 cycloalkenyl or heteroaryl; X2 and X3 are independently C1-4 alkyl, halo, halo-substituted C1-4 alkyl, hydroxy, C1-4 alkoxy, mercapto, C1-4 alkylthio, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl or the like; X1 is H, halo, C1-4 alkyl, hydroxy, cyano, nitro, C1-4 alkylthio, alkylsulfinyl, C1-4 alkylsulfonyl or the like; Y is -CR1=CR2- or -C.ident.C-, wherein R1 and R2 are independently H, methyl, ethyl or halo; and 1 is 0, 1, 2, 3 or 4; m and n are independently 0, 1, 2 or 3,with the proviso that when Z is phenyl; and 1, m and n are 0, Y is not -CH=CH-; and when Z is phenyl; l and m are 0; n is 1; and Y is -CH=CH-, X3 is not C1-4 alkoxy attached to the 2- position of Z, nor amino, C1-4 alkylamino or di(C1-4)alkylamino attached at 4-position of Z; and a pharmaceutical composition useful for the treatment of a mecical condition in which prostaglandins are implicated as pathogens.
Patent CA-2224381-A1 (CA)
Inventor: OKAMOTO KAYOKO
IPC: A61K38/27
Filed: 1996-06-26
Abstract: Cette invention concerne une préparation à libération prolongée comprenant un sel métallique de polymère biodégradable et un polypeptide bioactif, avec amélioration de piégeage des polypeptides bioactifs, suppression de la bouffée de départ et libération constante à long terme des polypeptides bioactifs.
Patent CA-2224552-A1 (CA)
Title: Aqueous nail lacquer
Inventor: HOOD ALAN ROGER
IPC: A61K8/00
Filed: 1996-06-11
Abstract: An aqueous nail lacquer comprising an alcohol soluble nitrocellulose, a plasticiser, an active solvent for dissolving the nitrocellulose and a bridging solvent soluble with the nitrocellulose, the active solvent and the water to form an aqueous nail lacquer solution.
Patent CA-2226036-A1 (CA)
Inventor: ETO SHUNJI
IPC: A01K69/00
Filed: 1997-12-31
Abstract: A device for collecting water polluting phytoplankton drifts and a method for collecting water polluting phytoplankton drifts by use of said device is provided such that the deterioration of water quality as a result of extraordinary proliferation of phytoplankton is suppressed and prevented such that a water area is kept clean. The device 1 for collecting water polluting phytoplankton drifts defines a predetermined volume of space therewithin with enclosing face means, said enclosing face means comprising at least one face section 3 composed of a water blocking member and other face sections 4 and 5 composed of a plurality of water admitting members, each water admitting member being formed with a plurality of water admitting holes.
Patent CA-2227293-A1 (CA)
Title: Element for manufacturing furniture drawers
Inventor: MIGLI CARLO
IPC: A47B88/00
Filed: 1998-01-19
Abstract: An element 10 for manufacturing a drawer is made of a bordered strip (11, 111, 211, 311, 411) which can be folded crosswise to its extension along scored lines (12, 13) to form the sides of a drawer. The strip has, on a first face, a rib (14) close to one edge of the strip and extending longitudinally to the extension of the strip.          The rib (14) is designed to fit into a groove (16) along the side of the base of the drawer. Disposed on the opposite face of the strip are runners (18, 19) secured to the strip by fastening means (23, 24) which traverse the strip to be at least partially contained in the cross section of the rib (14).
Patent CA-2227423-A1 (CA)
Title: Procedes de regulation du metabolisme de la nicotine
Inventor: TYNDALE RACHEL F
IPC: B82B1/00
Filed: 1997-07-17
Abstract: On décrit un procédé de régulation du métabolisme de la nicotine chez un individu, consistant à inhiber de manière sélective CYP2A6.
Patent CA-2227480-A1 (CA)
Title: Echo cancellation method and echo canceller implementing such a process
Inventor: BOUDY JEROME
IPC: H04M9/08
Filed: 1998-01-20
Abstract: A reception signal (x(n)) is input to an echo generator system  (1). An observation signal  (z(n))  is gathered  from  the  system.  The  reception  signal  is filtered to produce an echo prediction signal (y(n)). The echo prediction signal is subtracted from the observation signal to produce an error signal (e(n)). The observation signal  (z(n))  is decomposed into M spectral components relating to different frequencies of the spectrum.  M corresponding spectral components of the echo prediction signal (y(n)) are obtained. M quantities, each having a value with progressive  variation representative  of  a degree of similitude between, respectively, one of the M spectral components of the observation signal and the corresponding spectral component of the echo prediction signal, are calculated. At least one spectral shaping of the error signal (e(n)) is carried out as a function of these  M  calculated  quantities  so  as  to  adapt  the filtering and/or to deliver the output signal from the echo canceller.
Patent CA-2227482-A1 (CA)
Title: Swivel post anchor
Inventor: SPEECE STEPHEN
IPC: E04H12/22
Filed: 1998-01-20
Abstract: A fence post anchor that adjusts for vertical post alignment by providing a post engagement support portion that swivels on a ground securing portion.  The post engagement portion is defined by a split box sleeve secured to an adjustment dome.  A fastener assembly interconnects the adjustment dome to the ground engagement portion that has multiple engagement flights on which the dome can be movably positioned and secured thereto.
Patent CA-2229753-A1 (CA)
Title: Extrusion of degradable plastic material in tubular form
Inventor: PLANETA MIREK
IPC: B29C48/09
Filed: 1998-02-17
Abstract: A method of extruding degradable plastic material in tubular form includes providing an annular extrusion die having an annular extrusion orifice and a longitudinal extending annular passage for conveying plastic material to the extrusion orifice. The die also has at least one arcuate passage extending at least partly around the annular passage such that the annular passage completely surrounds, or wherethere is more than one arcuate passage in combination completely surround, the annular passage inwardly or outwardly thereof and are in communication therewith. A separate melt stream of degradable plastic material is provided for each arcuate passage and each separate melt stream of degradable plastic material is incorporated with non-degradable plastic material in a circumferentially continuous manner toproduce separate encapsulated melt streams. Each encapsulated melt stream is fedto a respective arcuate passage to cause encapsulated plastic material to pass into the annular passage with subsequent extrusion in tubular form from the annular die orifice.
Patent CA-2234775-A1 (CA)
Title: Printed document including bar code authentication system
Inventor: ROYER ALAIN
IPC: G06V30/224
Filed: 1996-10-14
Abstract: A printed document in which a bar code is imprinted on a surface thereof and entirely covered with a scratch-off layer, the removal of the scratch-off layer reveals the entire bar code thereby enabling easy authentication of the printed document.
Patent CA-2234925-A1 (CA)
Title: Method and composition for inhibiting mold fouling
Inventor: UMETSU KIYONORI
IPC: C08K5/3475
Filed: 1998-04-16
Abstract: A method for inhibiting fouling of a mold by a composition in which an elastomeris being cured, which comprises adding at least 0.3 parts of a compound of the formula (see fig. I) wherein R is hydrogen or lower alkyl or a salt thereof, per 100 parts of the elastomer in the composition prior to curing the elastomer in the mold.
Patent CA-2236901-A1 (CA)
Title: Fabric conditioning composition
Inventor: NESS JEREMY NICHOLAS
IPC: C11D3/20
Filed: 1996-11-04
Abstract: The invention concerns fabric condi-tioning compositions comprising at least 2 wt.% of a water insoluble cationic fabric softening agent and a perfume, characterized in that they further comprise a di- or tri-ester as set out under I, II and III: I. Diesters of monobasic acids and diols (a) where R1, R2 are independently C1-C10 alkyl chains or C2-C10 alkenyl chains, and R3, R4 are indepen-dently H, C1-C4 alkyl chains and n = 0-8. II.      Diesters of monohydric alcohols and dioic acids (b) where R1, R2 are independently C1-C18 alkyl chains or C2-C18 alkenyl chains, and R3, R4 are independently H, C1-C4 alkyl chains and n = 0-10. III. Triesters of glycerol and aliphatic carboxylic acids of up to 12 carbon atoms. Preferably the cationic fabric softening agents comprise two C12-28 alkyl or alkenyl groups connected to a quaternary nitrogen via an ester link. The perfumes are preferably present in an amount of 0.1-4 % w/w of the total composition and the di- and tri-esters are preferably present in an amount of at least 10 % w/w of the perfume.
Patent CA-2237252-A1 (CA)
Inventor: WHITE MICHAEL A
IPC: B31B3/28
Filed: 1998-05-08
Abstract: An improved horizontally-oriented machine capable of forming a trays or other similar fiberboard containers from single blanks. The improved machine includes three distinct sections: (1) a loading bay which includes a vertical lift, a sheet feeder, and a unique set of gates for pre-positioning the end flaps of container blanks for later folding; (2) an adhesion and flap-folding section which includes adhesive applicators, a series of folding plows and a compression area for pre-folding the end flaps of the container to be formed; and (3) a final forming section including an adjustable vertically mounted mandrel surrounded by adjustable forming plows for making the final container. The flap-folding section includes a flight chain assembly which can be easily lowered when the machine is not operating, to allow service access to the interior of the machine in the event of a jam or misfeed, thereby avoiding the time consuming task of cutting or tearing out the misfeed, and allowing the machine to be quickly brought back on line.
Patent CA-2237263-A1 (CA)
Title: Radionuclide labeling of vitamin b12 and coenzymes thereof
Inventor: COLLINS DOUGLAS A
IPC: A61P35/00
Filed: 1996-11-12
Abstract: A compound useful for in vivo imaging of organs and tumors is provided of formula (1) wherein (a) is cobalamin, (b) derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating group, optionally comprising a detectable radionuclide or a paramagnetic metal ion, and n is 1-3.
Patent CA-2237793-A1 (CA)
Title: Insulating connector rods used in making highly insulated composite wall structures
Inventor: KEITH DAVID O
IPC: B32B7/08
Filed: 1996-11-13
Abstract: Highly insulating and substantially pointed connector rods (10) used in making highly insulative composite wall structures.      At least a substantial portion of the connector rod (10) is injection molded in a single step from an appropriate resinous material or moldable plastic. The connector rod (10) has a first substantially pointed end (20) in a penetrating segment (14) for facilitating entry through an insulating layer (60) and for making abutting contact with a form sidewall (70) when manufacturing a composite wall structure using a cast-in-place method. The opposite end, or trailing segment (18) also includes a substantially pointed end (24) that makes abutting contact with another form sidewall (70). A middle or mesial segment (16) resides within the insulating layer (60), which is sandwiched between two structural layers (90) of a hardenable material, such as concrete. A first ridge or flange (26) at the intersection between the mesial (16) and trailing segments (18) limits the depth of penetration of the connector rod (10) when inserted through the insulating material. A second ridge or flange (36) that is attached thereafter to the connector rod (10) at the intersection between the mesial (16) and penetrating segments (14) locks the connector rots (10) in place in a desired orientation within the insulating layer (90).
Patent CA-2238421-A1 (CA)
Inventor: ROTH MARC W
IPC: B65D1/40
Filed: 1998-05-25
Abstract: A blow molded container adapted to receive a hot-fill product, having a base with an upwardly raised central portion including a plurality of radially extending triangular ribs, a generally cylindrical lower body portion including a label receiving area with a series of circumferentially spaced pressure responsive panels, a mouth defined by a finish portion at an upper extremity adapted to receive a closure, and a substantially spherical portion disposed between the finish portion and the lower body portion. The substantially spherical portion includes a surface feature pattern depicting a widely recognized object such as a sports ball, a sports helmet including a team identifying logo, a globe of the earth including an outline of major geological features, or a caricature of a personality.
Patent CA-2239952-A1 (CA)
Inventor: LAUX WOLFGANG
IPC: A61K9/70
Filed: 1996-12-04
Abstract: An active substance-containing transdermal pharmaceutical preparation with a given size of contact surface, comprising a tack-free backing layer which is permeable to active substances and an adhesive layer adhering to the skin is characterized by the fact that the backing layer comprises at least a third of the total active substance amount contained in the preparation.
Patent CA-2240690-A1 (CA)
Inventor: MUELLER HEINZ
IPC: E21B43/25
Filed: 1996-12-06
Abstract: The use is disclosed of oil-soluble, oleophilic organic liquid phases which are fluid at a temperature range from 0 to 10 ~C from the corresponding classes of mono- and/or polycarboxylic acid esters, carbon dioxide ester, fatty alcohols and their oligoalkoxide and/or ethers which constitute the at least major part of the liquid phase in storage-stable homogeneous mixtures with guar gum and/or water-soluble guar gum derivatives, to allow their use in water-based bore-hole treatment media.
Patent CA-2246594-A1 (CA)
Inventor: GREY NICHOLAS GERALD
IPC: A47L7/00
Filed: 1997-02-13
Abstract: In order to adapt a cleaning head (10) of the kind adapted for cleaning floor surfaces which are of a relatively unyielding and non-absorbent nature by the application and removal of a liquid to enable such heads to be used for dry suction cleaning in the manner of normal vacuum cleaner, a clip-on adaptor/cover member (50) is provided. The adapter/cover member (50) is formed to define an inlet slot (62) to register with a suction aperture (37) in the cleaning head and to enclose squeegee blades (35) provided on the head.  Additionally, the adaptor/cover member (50) includes a bottom wall (51) which extends over, and encloses, an applicator assembly (40) within the cleaning head whereby, in the absence of the adaptor/cover member, cleaning liquid can be applied to a surface being cleaned.
Patent CA-2246956-A1 (CA)
Title: A needle holder to assist in suturing
Inventor: KNODEL BRYAN D
IPC: A61B17/04
Filed: 1998-09-10
Abstract: In accordance with the present invention there is provided a device for assisting a physician in suture procedures, wherein the physician is using a needle and a suture attached thereto. The device includes a handle for holding the device. Extending distally from the handle are a pair of arms, right and left. The arms have proximal ends attached to the handle. The distal ends of the arms have grippers attached thereto, for gripping and releasing a needle. The device includes at least one means for moving the distal ends of the arms closely adjacent to one another so as to pass the needle from one gripper to the other. Thereafter, the device is able to move the distal ends of the arms further apart from one another, without any substantial movement of the needle with respect to the handle.
Patent CA-2253722-A1 (CA)
Inventor: MITIN BORIS SERGEEVICH
IPC: A62C19/00
Filed: 1997-05-14
Abstract: The present invention relates to a method for locating and/or extinguishing fires, wherein said method is mainly intended for fighting violent and large-scale fires in relatively inaccessible areas. This method comprises applying a combined action directly onto the fire region using a fine-dispersion air cloud (4) of a flame-retardant composition, an air shock wave (5) and a rapid air and detonation-product head which are all generated by the explosion of a dispersion load in a fire-extinguishing device (1) when the latter approaches the burning region. The fire-extinguishing device (1) comprises a vessel made of an ecologically clean material that is filled with a flame-retardant composition. The vessel is fitted with a dispersion charge and a sensor for a given parameter, such as altitude, said sensor being set at a given parameter (altitude) value. When the fire-extinguishing device (1) approaches the burning region and when the value is reached, the dispersion load explodes in a given fire sector. The dimensions and locations of the sectors where the fire must be extinguished are selected according to the type of fire and to the dimensions of the fine-dispersion cloud (4) of flame-retardant composition which is to be created.
Patent CA-2253870-A1 (CA)
Title: Inhibition of matrix metalloproteases by substituted phenalkyl compounds
Inventor: WOLANIN DONALD J
IPC: A61K31/215
Filed: 1997-05-12
Abstract: Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and the use of such compounds in the disease treatment is presented. The compounds of the invention have generalized formula (I), wherein T is a substituent, M is CO2H or an amide or ester derivative thereof, and R24 is a substituted amide moiety. These compounds are useful for inhibiting matrix metalloproteases and, therefore combatting conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, peptic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from athrosclerotic plaque rupture. The present invention also provides pharmaceutical compositions and their use in the treatment of such conditions.
Patent CA-2255642-A1 (CA)
Inventor: PANZERI EZIO
IPC: G07D5/10
Filed: 1997-05-17
Abstract: A method of coin testing is provided in which a laser beam (13) is directed onto a face of a coin (4) and a laser detector (3) is used to detect where the laser beam is intercepted by the coin and where the laser beam is not intercepted by the coin, so as to obtain an indication of a characteristic of the face of the coin. The characteristic of the coin is used to identify the coin. The invention also relates to an apparatus for coin testing, which comprises a laser source (11) to direct a laser beam (13) onto a face of a coin (4), a laser detector (3) for detecting where the laser is intercepted by the coin and where the laser is not intercepted by the coin, and a signal-processor (14) which obtains an indication, from an output of the laser detector (3), of a characteristic of the face of the coin which is used to identify the coin.
Patent CA-2258841-A1 (CA)
Title: Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug
Inventor: DIJKGRAAF BERNARDUS LEONARDUS
IPC: A61K9/20
Filed: 1997-06-19
Abstract: A granulate, containing an active ingredient, having a solubility in water of 1: > 10, in admixture with <=15 wt.% of a water dispersible cellulose, is provided for the preparation of fast-disintegrating and fast-dissolving compositions.
Patent CA-2260274-A1 (CA)
Title: Heat-stable dna polymerase of archaeobacteria of genus pyrococcus sp.
Inventor: CAMBON MARIE-ANNE
IPC: C12N15/54
Filed: 1997-07-10
Abstract: A purified heat-stable DNA polymerase of archaeobacteria of genus Pyrococcus sp. having a molecular weight of around 89,000-90,000 daltons is disclosed.