Patent SG-11201909367V-A (SG)
Title: Methods for renal function determination
Inventor: RAJAGOPALAN RAGHAVAN
IPC: C07D241/20
Filed: 2018-10-26
Abstract: 12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 May 2019 (02.05.2019) WIPO I PCT 111111111111110111111111111111101111101001111111111111111111110111111111111011110111111 (10) International Publication Number WO 2019/084425 Al (51) International Patent Classification: A 61K 49/00 (2006.01) CO7D 241/20 (2006.01) A61P 13/12 (2006.01) (21) International Application Number: PCT/US2018/057743 (22) International Filing Date: 26 October 2018 (26.10.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/577,951 27 October 2017 (27.10.2017) US (71) Applicant: MEDIBEACON INC. [US/US]; 1100 Corpo- rate Square Drive, Helix Center, Suite 175, St. Louis, Mis- souri 63132 (US). (72) Inventors: RAJAGOPALAN, Raghavan; 5097 Neptune Drive, Solon, Ohio 44139 (US). DORSHOW, Richard B.; 11077 Niehaus Lane, St. Louis, Missouri 63146 (US). NEUMANN, William L.; 1100 Corporate Square Drive, Helix Center, Suite 175, St. Louis, Missouri 63132 (US). ROGERS, Thomas E.; 1100 Corporate Square Drive, He- lix Center, Suite 175, St. Louis, Missouri 63132 (US). (74) Agent: FLOREK, Erin M. et al.; Armstrong Teas- dale LLP, 7700 Forsyth Boulevard, St. Louis, Missouri 63105-1847 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: METHODS FOR RENAL FUNCTION DETERMINATION 1E+05 A 1E+04 E rn 1000 47J IC 4- , 5 100 O 10 mGFR = 120mL/nnin 1 200 400 600 800 Time (minutes) FIG. 3A (57) : The present disclosure relates to systems and methods for determining the renal glomemlar filtration rate or assessing the renal function in a patient in need thereof. The method includes administering a pyrazine compound of Formula (I) to a patient and monitoring the rate in which the kidneys of the patient eliminate the pyrazine from the systemic circulation of the patient. The pyrazine compound fluoresces when exposed to electromagnetic radiation which is detected using one or more sensors. The rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient. [Continued on next page] WO 2019/084425 Al 1010 1 001 11111 II H (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with amended claims (Art. 19(1))