Patent RU-2243214-C2 (RU)
Inventor: ANDERSSON K ELL
IPC: C07C69/612
Filed: 1999-05-31
Granted: 2004-12-27
Abstract: FIELD: organic chemistry, medicine, endocrinology, pharmacy. 
     SUBSTANCE: invention relates to new derivatives and analogues of 3-arylpropionic acid of the general formula (I)  , 
      their seteroisomers, optical isomers and racemates and to their pharmaceutically acceptable salts. The group A in the indicated formula (I) is at meta- or para-position and it represents    
     wherein R represents hydrogen atom; -OR a  wherein R a  represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NR a R b  wherein R a  and R b  are similar or different and represent hydrogen atom, alkyl, phenyl, alkylphenyl, cyano-group; R 1  represents alkyl, cyano-group; -OR e  wherein R e  represents alkyl, phenyl or alkylphenyl; -O-[CH 2 ] m -OR f  wherein R f  represents alkyl; m represents a whole number 1-2; -SR d  wherein R d  represents alkyl or phenyl; -SO 2 OR a  wherein R a  represents alkyl, phenyl or alkylphenyl; -COOR d  wherein R d  represents alkyl; R 2  represents hydrogen atom or alkyl; R 3  and R 4  are similar or different and each represents hydrogen atom or alkyl; n represents a whole number 1-3; D is at ortho-, meta- or position and represents -OSO 2 R d  wherein R d  represents alkyl, phenyl or alkylphenyl; -OCONR f R a  wherein R f  and R a  represent hydrogen atom, alkyl, phenyl or alkylphenyl; -NR c COOR d  wherein R c  represents hydrogen atom or alkyl, and R d  represents alkyl, phenyl or alkylphenyl; -NR c COR a  wherein R c  represents hydrogen atom or alkyl, and R a  represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NR c R d  wherein R c  and R d  represent hydrogen atom, alkyl, phenyl or alkylphenyl; -NR c SO 2 R d  wherein R c  represents hydrogen atom or alkyl, and R d  represents alkyl, phenyl or alkylphenyl; -NR c CONR a R k  wherein R c  represents hydrogen atom, R a  and R k  are similar or different and each represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NR c CSNR a R k  wherein R c  represents hydrogen atom, R a  and R k  are similar or different and each represents hydrogen atom, phenyl or alkylphenyl; -SO 2 R d  wherein R d  represents alkyl, phenyl or alkylphenyl; -SR c  wherein R c  represents alkyl, phenyl or alkylphenyl; -SO 2 OR a  wherein R a  represents alkyl, phenyl or alkylphenyl; -CN; -CONR c R a  wherein R c  represents hydrogen atom or alkyl and R a  represents hydrogen atom or alkyl; D is at meta-position and represents -OR f  wherein R f  represents alkyl, or it represents hydrogen atom; D'' is at ortho-, meta- or para-position and represents hydrogen atom wherein indicated alkyl a direct or branched alkyl group comprising from 1 to 6 carbon atoms, either cyclic alkyl comprising from 3 to 6 carbon atoms being indicated alkyl can be substituted with one or more group taken among alkyl, alkoxy-, halogen atom or phenyl wherein indicated phenyl can be substituted with one or more group taken among alkyl, alkoxy-, nitro-, thiol or halogen atom. Also, invention relates to a method for their preparing, pharmaceutical preparations comprising thereof and applying these compounds in clinical states associated with resistance to insulin. 
     EFFECT: valuable medicinal properties of compounds. 
     41 cl, 109 ex