baber/WOPTO huggingface dataset:
Patent JP-2001527652-A (JP)
Title: 超低温での零シフト非線形性を補償する圧力センサ
IPC: G01L9/04
Filed: 1999-03-19
Abstract: (57)【要約】
超低温におけるブリッジの零ドリフトの非線形性を補償するために、ブリッジ（１０）のアームの少なくとも一つの歪ゲージを、歪ゲージよりも抵抗がかなり小さい抵抗器（ｃ）、例えば接続リードと直列に配設し、補償回路は、超低温域において、一部を形成する並列回路の抵抗に影響を及ぼし、温度に敏感で温度が低下するにつれて増大するように温度の関数として抵抗が変化する抵抗素子、例えばプラチナプローブ（Ｐ）を有している。
Patent JP-2002501511-A (JP)
Title: 脂質小胞への荷電した治療剤の高率封入
IPC: A61K47/28
Filed: 1998-05-14
Abstract: (57)【要約】
脂質−核酸組成物を調製する方法を提供する。本方法に従って、プロトン付加可能なまたはプロトン遊離可能な脂質、例えばアミノ脂質及びPEGまたはポリアミドオリゴマー修飾脂質のような脂質を含む脂質の混合物を、荷電した治療物質、例えばポリアニオン核酸の緩衝水溶液と混合し、治療剤が脂質小胞に封入されている粒子を作成する。脂質粒子上の表面荷電は少なくとも部分的に中和されて、治療物質の表面が中和された脂質封入組成物が提供される。本方法によって、脂質に対する治療物質の比が高く、封入効率が50％を超える組成物が調製される。
Patent JP-2002507279-A (JP)
Title: 圧力センサ
IPC: G01L11/06
Filed: 1998-07-15
Abstract: (57)【要約】
圧力センサおよび関連する圧力検出プロセスは光束空洞またはその他の積分球内の複式散乱光線、またはその他の波動伝搬エネルギを検出することに依っている。空洞内部は空洞の内表面の光散乱表面、または空洞に充填された、光散乱特性を有する材料からなっており、いずれの場合も、わずかな発生源の周囲領域の散乱光の光度を上昇させる。空洞内のエネルギ発生源および検出器は、検出器が空洞の変形による光度の上昇を測定できるように、互いに充分に近接して配置されている。空洞の容積の変化はサンプリングされた光度の変化によって検出される。光ファイバ技術を利用して、高密度のセンサを有する感圧マットが組立てられる。この装置はまた、散乱エネルギ源として音波を利用するようにしてもよい。
Patent MD-20060277-A (MD)
Inventor: RASSOHIN ION
IPC: F16D1/08
Filed: 2006-12-14
Abstract: Inventia se refera la industria constructoare de masini, si anume la imbinarile arborilor. Cuplajulcu manson contine o bucsa cu gaura centrala patrata, pe centrul suprafetelor careia sunt executate gauri radiale, pene-segment cu varf cilindric instalate in gaurile radiale, suruburi si saibe, prin care penele-segment sunt fixate de bucsa. In gaurapatrata a bucsei este introdus capatul canelat alunui arbore.
Patent MX-146061-A (MX)
Inventor: PERLE JOSEF
IPC: H01H33/12
Filed: 1979-09-28
Abstract: 1. A shallow quench chamber (30) for a load disconnection switch with pivotably mounted trailing blades (28), the shallow quench chamber comprising a synthetic shallow housing which accommodates a trailing blade contact (24) and consists of a material which gives off a quench gas, and which has a narrow quench chamber extending at least over the range of pivotal movement of the trailing blade, characterised in that the synthetic shallow housing consists of elastically deformable plates (42, 44) which form the sidewalls of the quench chamber and an essentially stiff L-shaped carrier frame (34) which is of substantially U-shaped cross-section, with the support and cover wall side edge regions of these plates (42, 44) being fastened to the inner sides of the limbs of the carrier frame (34) of U-shaped cross-section.
Patent MX-152280-A (MX)
Inventor: MARKUS GERARDUS ANTHONIUS
IPC: F24H1/40
Filed: 1981-06-16
Abstract: A heater for heating a process fluid in which a cylindrical main chamber has a number of high intensity burners mounted therein to project products of combustion into the main chamber in a direction transverse to the axis of the main chamber. An annular secondary chamber surrounds the longitudinal walls of the main chamber, a first set of heat exchanger tubes being provided in the main chamber and a second set in the secondary chamber. Gases flowing from the burners pass over the first set of heat exchanger tubes, and then through at least one inlet to the secondary chamber, where they pass over the second set of heat exchanger tubes and out through a flue outlet at the top. A refractory shield may be provided adjacent the burners to guide the gases from the main chamber into the secondary chamber, and a further heat shield may be provided between the main chamber and the secondary chamber.
Patent NZ-204141-A (NZ)
Title: Apparatus and method for transferring a bingham solid through a long conduit
Inventor: COURSEN D L
IPC: E21B43/26
Filed: 1983-05-05
Abstract: An apparatus for injecting a lubricating liquid, e.g., water, into a conduit as an annular layer around a flowing Bingham solid, e.g., a water gel or water-in-oil emulsion explosive, to facilitate the flow of the Bingham solid has an annular passageway from which the lubricating liquid flows into a cylindrical chamber containing the flowing Bingham solid. The annular passageway has a constricted throat portion of adjustable width, which, along with the flow rates of the Bingham solid and the lubricating liquid, is adjusted to produce a thin film of lubricant which allows lubricated plug flow of the Bingham solid in a descending section of conduit under the propelling force of gravity alone. Low drag permits the delivery of Bingham solid explosives into very deep vertical holes with no increase in the required pumping pressure.
Patent NZ-210665-A (NZ)
Title: Tetrahydrobenzindoles and pharmaceutical compositions containing such
Inventor: GLASER T
IPC: C07D209/90
Filed: 1984-12-20
Abstract: 1. Tetrahydrobenzindoles of the general formula  see diagramm : EP0148440,P9,F1  in which R1  and R2 denote hydrogen or C1 -C6 -alkyl or, together with the nitrogen atom, form a heterocyclic 5-membered or 6-membered ring which is optionally substituted by 1 or 2 C1 -C6 -alkyl groups, and X represents OR3  or SR3 , wherein R3  denotes hydrogen or C1 -C4 -alkyl, and salts thereof.
Patent NZ-222342-A (NZ)
Title: Catalyst containing ag, re, and a promoter, for converting ethene to ethene oxide
Inventor: LAURITZEN A M
IPC: B01J23/32
Filed: 1987-10-29
Abstract: A composition containing silver, a support, rhenium and at least one further metal, characterized in that the selected amounts of the metals or compounds are such that under conditions of catalytic manufacture of e thylene oxide from ethylene and oxygen the composition comprises a catalytically effective amount of silver, a promoting amount of rhenium or compound thereof and a promoting amount of at least one further metal or compound thereof.
Patent NZ-232078-A (NZ)
Title: Delivery device powered by a hydrogel
Inventor: CURATOLO WILLIAM JOHN
IPC: A61K9/36
Filed: 1990-01-11
Abstract: This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by hydrogel, are powered by hydrogel, comprising a layer made of a mixture of one or more beneficial agents and a hydrogel, a second layer of hydrogel and a coating. This invention also relates to the controlled delivery of one or more beneficial agents to an aqueous environment of use through the use of such hydrogel powered dispensing devices. Also disclosed are methods for the controlled delivery of one or more beneficial agents to an aqueous environment of use which comprises administering to or otherwise placing the devices of this invention in the environment of use.
Patent NZ-242078-A (NZ)
Title: Indole derivatives, pharmaceutical compositions and intermediates therefor
Inventor: FESTAL DIDIER
IPC: C07D405/04
Filed: 1992-03-20
Abstract: The invention relates to indole derivatives of formula 1,   <IMAGE> 1 in which: R1 and R2 represent H, alkyl, alkenyl, cycloalkyl, N-alkylamino- or N,N-dialkylaminoalkyl, benzyl, pyridylmethyl or phenyl, optionally substituted, R3 and R4 represent H, halogen, alkyl, alkoxy, alkylthio, CF3, NO2, N-alkylamino or N,N-dialkylamino, benzyl or phenyl, optionally substituted, R5 represents H, alkyl, cycloalkyl or optionally substituted benzyl, R6 denotes an alkyl, phenyl or heterocyclic radical, optionally substituted, Z denotes the bivalent radicals -(CH2)n-C(R7R8)-(CH2)p-, -CH=CH-C(R7R8)- in which n=0-2, p=0-2 and n+p</=2, R7 and R8 represent H, alkyl, alkenyl, cycloalkyl, N-alkylamino, N,N-dialkylamino, N-alkylamino- or N,N-dialkylaminoalkyl, benzyl or phenyl, where appropriate substituted, or together form polymethylene or oxa-, thia- or azapolymethylene chains, as well as their tautomeric forms, to processes for preparing them and to their application as hypolipidaemic, antiatheromatous and antidiabetic pharmaceutical products.
Patent NZ-244324-A (NZ)
Title: 3-quinuclidinyl ester derivatives, intermediate therefor, and
Inventor: CROSS PETER EDWARD
IPC: A61P25/30
Filed: 1992-09-14
Abstract: PCT No. PCT/EP92/02067 Sec. 371 Date Jul. 5, 1994 Sec. 102(e) Date Jul. 5, 1994 PCT Filed Sep. 3, 1992 PCT Pub. No. WO93/06098 PCT Pub. Date Apr. 1, 1993   <IMAGE>  (I)   <IMAGE>  (Ya)   <IMAGE>  (Yb)  Compounds of formula (I) wherein X is either (a) a phenyl group optionally substituted by 1 or 2 substituents each independently selected from halo, CF3, C1-C4 alkyl, C1-C4 alkoxy and hydroxy or (b) a thienyl group; and Y is of formula (Ya) or (Yb) where A and B are 0, 1 or 2, D and E are 0 or 1, F is 0-3 and D+E+F=1-3, Z is 0, 1 or 2, R1 and R2 are H or alkyl or form a ring, and R3 is C1-C4 alkyl, C3-C6 cycloalkyl or optionally substituted phenyl or benzyl, are antimuscarinic bronchodilators useful for treating chronic obstructive airways disease or asthma.
Patent NZ-246274-A (NZ)
Title: Treating periodontal disease using 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid or salts thereof
Inventor: GERTZ BARRY J
IPC: A61K31/66
Filed: 1992-12-08
Abstract: This invention claims a method for treating periodontal disease in mammals, including humans, by administering an effective amount of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or a pharmaceutically acceptable salt including the monosodium salt tridydrate (alendronate) of the formula:  <IMAGE>   The compounds are useful in the treatment of alveolar bone loss associated with peridontitis and periodontal disease.
Patent NZ-270727-A (NZ)
Title: Piperidine derivatives and pharmaceutical compositions
Inventor: BICHON DANIEL
IPC: C07D401/02
Filed: 1995-03-16
Abstract: N-(3,4-dichlorophenyl-propyl)-piperidine derivs. of formula (I) and their salts are new. Ar = pyrid-2-yl or phenyl (opt. substd. by halo, methyl or (1-4C)alkoxy); R1 = methyl; R11 = H; or R1+R11 = -(CH2)3-; R2 = (1-7C)- alkoxy, acryloxy, acyl, allkoxycarbonyl, alkoxymethyl, acyloxymethyl or alkylamino-carbonyloxymethyl, or CN, -CH2OH, OH, -NR6R7, -NR3COR4, -NR3COOR8, -NR3SO2R9, -NR3CONR10R12, -CONR10R12, -CH2NR13R14, -CH2NR3COR4, -CH2NR3COOR8, -CH2NR3SO2R9 or -CH2NR3CONR10R12, or R2 forms a double bond between the C to which it is attached and the adjacent C in the piperidine ring; or CR2Ar = a gp. (i); R3 = H or (1-4C) alkyl; R4 = H, (1-7C)alkyl, phenyl, benzyl, pyridyl or (3-7C)cycloalkyl (opt. substd. by one or more methyl); or R3+R4 = -(CH2)n-; n = 3 or 4; T = methylene, carbonyl, -COO- or -CONR5-; A = a bond, methylene, ethylene, propylene or vinylene; or -T-A- = -SO2-; Z = phenyl (opt. substd. by one or more halo, (1-4C)alkyl or alkoxy, or nitro); R5 = H or (1-4C)alkyl; R6 = H or (1-7C)alkyl; R7 = H, (1-7C)alkyl, (3-7C)cycloalkylmethyl, benzyl or phenyl; or NR6R7 = azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine or perhydroazepine; R8 = (1-7C)alkyl or phenyl; R9 = (1-7C)alkyl, or amino (opt. substd. by one or two (1-7C)alkyl), phenyl (opt. substd. by one or more (1-7C)- alkyl, alkoxy, alkoxycarbonyl or alkylcarbonyloxy, or halo, CF3, hydroxy, carboxy, cyano, nitro or amino (opt. substd. by one or two (1-7C)alkyl)); R10 = H or (1-7C)alkyl; R12 = H, (1-7C)alkyl, (3-7C) cycloalkyl or cycloalkylmethyl, hydroxy, (1-4C)alkoxy, benzyl or phenyl; or NR10R12 = a heterocyclic gp. as for NR6R7; R13 = H or (1-7C)alkyl; R14 = H, (1-7C)alkyl, (3-7C)cycloalkylmethyl or benzyl; with the provisos that: a) when Ar = phenyl, R2 = hydroxy and T-A-Z = benzoyl, then R1 is not methyl; b) when Ar = phenyl, R2 = -NH-CO-CH3 and T-A-Z = benzoyl or 3-methoxybenzyl then R1+R11 is not -(CH2)3-. Also claimed are the piperidine derivs. of formula (V) and their salts. R2' = -NR3COR4; R3, R4 are as defined except when R3 = H then R4 is not methyl; Y = H or a protective gp.. Also claimed is the starting material of formula (1') and its acid addn. salts, pref. the (+) isomer.
Patent NZ-277906-A (NZ)
Title: Bonded elastic article; method of bonding elastic material to substrate by ultrasonic welding, elastic material comprises thermoplastic threads
Inventor: WIDLUND URBAN
IPC: B29C65/48
Filed: 1994-12-21
Abstract: PCT No. PCT/SE94/01236 Sec. 371 Date Jun. 18, 1996 Sec. 102(e) Date Jun. 18, 1996 PCT Filed Dec. 21, 1994 PCT Pub. No. WO95/17296 PCT Pub. Date Jun. 29, 1995Elastic tapes consisting of non-weldable elastic warp threads and weldable thermoplastic weft threads, are fixed to one side of a cover layer of a disposable diaper by ultrasonic welding of the thermoplastic weft threads
Patent NZ-278882-A (NZ)
Title: Piperazine-containing azole antifungal compounds
Inventor: HEERES JAN
IPC: C07D521/00
Filed: 1995-01-17
Abstract: PCT No. PCT/EP95/00174 Sec. 371 Date Jun. 20, 1996 Sec. 102(e) Date Jun. 20, 1996 PCT Filed Jan. 17, 1995 PCT Pub. No. WO95/19983 PCT Pub. Date Jul. 27, 1995A compound of formula (I),    <IMAGE>  (I)  or a stereochemically isomeric form thereof, wherein A and B taken together form -N=CH-, -CH=N-, -CH2-CH2, CH=CH-, -C(=O)-CH2-, -CH2-C(=O); D is a radical of formula    <IMAGE>  (D1)   <IMAGE>  (D2) GE>  (L1)   <IMAGE>  (L2)  Alk is a C1-4alkanediyl radical; R1 is halo; R2 is hydrogen or halo; R3 is hydrogen, C1-6alkyl, phenyl or halophenyl; R4 is hydrogen, C1-6alkyl, phenyl or halophenyl; R5 is hydrogen or C1-6alkyl; R6 is hydrogen, C1-6alkyl, C1-6alkyloxycarbonyl, or R5 and R6 taken together with the nitrogen atom to which they are attached form a heterocyclic ring. Active intermediates, compositions and methods of preparing compounds, compositions are described.
Patent NZ-279674-A (NZ)
Title: Rapidly dissolving oral dosage form containing a particulate support matrix
Inventor: ALLEN LLOYD V
IPC: A61K9/16
Filed: 1995-01-24
Abstract: The present invention concerns a particulate support matrix, a solid dosage form made therefrom, and processes for making such support matrices and dosage forms, which desintegrate or dissolve in a matter of just a few seconds once placed into the oral cavity. First, a porous particulate powder which will serve as the tablet support matrix is produced. In the second step, the pharmaceutical, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In the third step the mixture is formed into a tablet. Finally, in the fourth step, a coating may be applied to the outer surface of the tablet to enhance the intactness and durability of the tablet.
Patent NZ-290413-A (NZ)
Title: Extruding fresh cheese into shapes that do not collapse
Inventor: LANTING FEICO
IPC: A01J25/00
Filed: 1995-07-13
Abstract: Process for preparing fresh cheese having a fancy shape wherein fresh cheese is extruded through a nozzle in such condition that the shape of the product as extruded does not collapse and fancy shaped portion of fresh cheese is obtained.
Patent NZ-331163-A (NZ)
Title: Composition comprising interleukin-1 inhibitor and hydrogel ester (hyaluronan) for treating inflammatory diseases
Inventor: COLLINS DAVID S
IPC: A61K45/00
Filed: 1997-02-10
Abstract: The specification describes a pharmaceutical composition comprising: (a)an effective amount of a hydrogel ester, such as hyaluronan, and (b)an effective amount of a IL-1ra. Preferably, the hydrogel ester is present in a range of 0.1-5% w/v and the IL-1Ra is present in a range of 0.1-200mg/ml. The composition exhibits a therapeutic effect on inflammation and is useful for treating IL-1 mediated inflammatory diseases, particularly diseases of the joint.
Patent NZ-332891-A (NZ)
Title: Drain filtering device with debris being forced up ramped filter between guttering to downspout
Inventor: SILVA CHARLES
IPC: B01D35/22
Filed: 1996-05-21
Abstract: A drain filtering device (44) is disclosed. Stated improvement over the prior art is comprised of reducing the filter size from an elongated device that spans the length of the gutter system (46) to a modular unit which is necessary only at the drain site. An inclined upper face (54) is positioned on the upstream side of the drain in the gutter and a down spout attachment locates device 44 in the gutter such that the flow of filtered water passes into the downspout. The debris (58) that collects in the gutter is carried along with the water until it makes contact with the inclined upper face (54) and is forced up the incline until the overflow debris (66) flows over the side of the gutter (46) thereby cleaning same and preventing the downspout (64) from becoming clogged.
Patent NZ-333390-A (NZ)
Title: Boron-containing peptides and bifunctional serine protease inhibitors
Inventor: DEADMAN JOHN JOSEPH
IPC: C07K5/06
Filed: 1997-06-11
Abstract: This method of making a peptide or peptide-containing compound comprises: a)	providing a solid phase having a coupled thereto functional groups; b)	causing a compound reactive with the functional groups selectively to react therewith; the reacted compound having a functional group capable of reacting with an amino group or with a carboxyl group or a reactive derivative thereof; c)	causing the amino or carboxyl group of a terminal amino acid of a target amino acid sequence selectively to react with the functional groups of the reacted compound; d)	coupling the amino acid sequentially following, in the target sequence, the sequentially preceding amino acid coupled to the solid phase of the preceding amino acid; e)	repeating step (d) as often as necessary and f)	cleaving a solid phase linked compound prepared using steps (a)-(e) from the solid phase by the action of an acid or base. A compound comprising a boronic acid group [-BOH)2] or a derivative thereof is incorporated in the solid phase-linked compound prior to its cleavage from the solid phase.
Patent NZ-335502-A (NZ)
Title: Broadband telecommunications system interface for use between ISDN system and ATM system
Inventor: CHRISTIE JOSEPH M
IPC: H04J3/24
Filed: 1997-11-11
Abstract: A telecommunications system for use between an asynchronous system and integrated services digital network (ISDN) system for telecommunications calls comprises: - a signaling processing system configured to process call signaling from the ISDN system and from the asynchronous system, to select at least one of a ISDN connections and an synchronous identifier for each call and to provide control messages that identify the selected connections and identifiers and - a bearer interface external to the signaling processing system and configured to receive the control messages from the signaling processing system and to interwork call communications between the ISDN system and the asynchronous system using the selected connections and identifiers based on the control messages.
Patent NZ-337765-A (NZ)
Title: Recombinant antibodies having specificity for beta-amyloid N-terminus and C-terminus and use in treating Alzheimer's Disease
Inventor: CHAIN DANIEL G
IPC: A61K39/00
Filed: 1998-04-09
Abstract: DNA encoding a recombinant antibody molecule end-specific for the N-terminus or C-terminus of an amyloid-b peptide is provided.  The DNA or recombinant antibody may be used in a method for preventing or inhibiting progression of Alzheimer's Disease by preventing the accumulation of amyloid-b peptides in the cerebrospinal fluid.
Patent NZ-505538-A (NZ)
Title: A vaccine comprising immunogenic acyl glyceryl phosphatidylinositol manno-oligosaccharide (PIM); and the use of PIM for inducing an immune response in a patient effective in the prevention or treatment of Th2-mediated diseases or disorders such as asthma
Inventor: LE GROS GRAHAM STEPHEN
IPC: A61K39/39
Filed: 2000-07-03
Abstract: Disclosed herein is a vaccine for inducing an immune response in a patient effective in the prophylactic treatment against, or therapeutic treatment of, a Th2-mediated disease or disorder which comprises as active agent, immunogenic acyl glyceryl phosphatidylinositol manno-oligiosaccharide (PIM), in immunogenic form. Also described is prophylactic treatment against, or therapeutic treatment of Th2-mediated diseases or disorders.
Patent NZ-510904-A (NZ)
Title: An process for the preparation of antidiabetic agents
Inventor: SIRIPRAGADA MAHENDER RAO
IPC: C07D265/38
Filed: 1999-04-16
Abstract: A process for the preparation of a compound of formula (1), wherein R1 represents hydrogen or lower alkyl and X represents hydrogen or halogen. The process starts with p-hydroxybenzaldehyde, with the steps described herein. Also disclosed are: (a) compounds of formula (11') wherein R1 is an acetyl group, (b) compounds of formula (12) wherein R1 is hydrogen or lower alkyl and R2 is lower alkyl, and (c) compounds of formula (14) wherein R1 is hydrogen or lower alkyl, R2 is lower alkyl and X is halogen.
Patent NZ-511786-A (NZ)
Title: New plants formed by microparticle bombardment with uncharacterised DNA
Inventor: HENRY ROBERT JAMES
IPC: C12N15/82
Filed: 1999-10-18
Abstract: A method of plant gene transfer is provided which includes microprojectile bombardment using DNA directly isolated from a donor plant. Also provided are transgenic plants, cells and tissues thereof and progeny plants derived therefrom, the genomes of which have significant introgressions of the donor plant genome integrated therein.
Patent NZ-512331-A (NZ)
Title: Surgical reamer and method of using same
Inventor: GREEN JAMES M
IPC: A61B17/32
Filed: 2000-02-01
Abstract: A device (10) for expedited reaming of a medullary canal and method of using the same are disclosed.  The device includes a reamer head (20; 20') connected at the distal end of a rotatable drive shaft.  The reamer head (20; 20') has a cutting head with a plurality of blades and flutes therebetween.  Each blade has a front cutting portion.  At least some of the blades have a front cutting portion that includes at least two and preferably at least three planar surfaces.  The blades can also include a side cutting portion.  The disclosed method for removing material from the medullary canal of a bone includes the steps of reaming an area of the medullary canal to remove material; irrigating the material to be removed while reaming to reduce generation of heat and move removed material from the reaming area; and aspirating the removed material while reaming to create a negative intramedullary canal pressure to assist in the removal of the material
Patent NZ-519919-A (NZ)
Title: Imidazole substituted by an indene, indane or benzofuran derivative useful as alpha2 receptor agonist
Inventor: HUHTALA PAAVO
IPC: C07D405/06
Filed: 2001-01-12
Abstract: An imidazole derivative or a pharmaceutically acceptable ester or salt thereof has the formula (I) wherein: X is -CH2-(CH2)p-, -O-, =NH or -S-; R1 is optionally substituted phenyl, naphthyl, 1, 2, 3, 4- tetrahydronaphthyl, cycloalkyl, cycloalkenyl, cycloalkynyl or a mono- or bicyclic aromatic or optionally saturated heterocyclic group with 5 to 10 ring atoms which are carbon atoms and one to three heteroatoms selected from N, O and S; R2 is H or alkyl; R3 is H or alkyl; R4 is H or alkyl; R5 is H, or R5 and R7 form together a bond; each R6 is independently halogen, -OH, -NH2, haloalkyl, alkyl, alkoxy or OH-alkyl; R7 is H, OH or alkyl, or R7 and R5 form together a bond; each R8 is independently OH, alkyl, haloalkyl or alkoxy; m is 0 to 3; n is 0 or 1; p is 0 or 1; r is 0 or 1 and t is 0,1 or 2. The compounds are useful for treating neurological, psychiatric, cognition disorder, diabetes, a lipolytic disorder, orthostatic hypotension or sexual dysfunction.
Patent NZ-520466-A (NZ)
Title: Outer membrane vesicle (OMV) vaccine comprising n. meningitidis serogroup B outer membrane proteins
Inventor: PIZZA MARIAGRAZIA
IPC: A61K39/00
Filed: 2001-01-17
Abstract: A  composition  comprising (a) Neisseria  meningitidis serogroup  B  outer  membrane vesicles (OMVs),  and  (b)  an immunogenic   component  selected   from   other   Neisseria proteins,  or  immunogenic fragments thereof. Component  (b) preferably  includes a protein from a different  NmB  strain from  that  from which the OMV of component (a) is  derived. The   OMVs   are   preferably   obtained   by   deoxycholate extraction.  Such  compositions  are  useful  as  a  vaccine against  Neisseria  meningitidis. The composition  may  also comprise a protective antigen against other pathogens.