baber/WOPTO huggingface dataset:
Patent WO-02102985-B1 (WO)
Title: Pate, gene exprime dans le cancer de la prostate, la prostate et les testicules, et ses utilisations
Inventor: PASTAN IRA H
IPC: C07K16/30
Filed: 2002-06-14
Abstract: L'invention concerne un anticorps qui se fixe précisément à un polypeptide PATE, et une séquence nucléotidique qui contient un promoteur de PATE ou un variant conservateur de ce dernier. L'invention a également trait à des méthodes de détection du cancer de la prostate chez un sujet. Selon un mode de réalisation, l'invention concerne une méthode visant à produire chez un sujet une réponse immunitaire contre une cellule exprimant un polypeptide PATE. Selon un autre mode de réalisation, l'invention concerne une méthode permettant d'inhiber la croissance d'une cellule maligne exprimant un polypeptide PATE. L'invention concerne également une méthode visant à réduire le nombre de cellules prostatiques cancéreuses chez un sujet, notamment par administration à ce dernier d'une dose thérapeutiquement efficace du polypeptide PATE ou d'un polynucléotide codant le polypeptide PATE. L'invention a trait à des matériels de détection des polypeptides PATE et des polynucléotides PATE. Selon un mode de réalisation, lesdits matériels servent à détecter le cancer de la prostate. L'invention concerne également un procédé permettant d'augmenter la prolifération d'une cellule prostatique. Le procédé consiste à mettre la cellule prostatique en contact avec un polypeptide PATE ou à transfecter la cellule prostatique avec un acide nucléique codant le polypeptide PATE, ce qui augmente la prolifération de la cellule prostatique.
Patent WO-03087564-B1 (WO)
Title: Procedes, processus, systemes et appareils de la technologie de combustion de l'eau pour la combustion d'hydrogene et d'oxygene
Inventor: HAASE RICHARD A
IPC: F03G6/00
Filed: 2003-04-10
Abstract: L'invention concerne des systèmes et des procédés de combustion améliorée de la technologie de combustion de l'eau, reposant sur la chimie de l'eau (H2O) incorporant de l'hydrogène (H2) et de l'oxygène (O2), ainsi que l'utilisation de H2O comme combustible. Cette technologie de combustion de l'eau décrite dans ladite invention a recours à l'hydrogène combiné à de l'oxygène, puis, dans un second temps, combiné avec l'air. Ledit produit primaire de la combustion de H2 et O2 est H2O. En outre, ladite technologie permet de séparer H2O en H2 et O2, ce qui fait de H2O un procédé efficace de stockage de combustible. En outre, ladite technologie de combustion de l'eau a trait à la combustion, H2O étant ajoutée au mélange de combustible dans une chambre à combustion d'un moteur à combustion afin de réguler la température de combustion, ce qui permet d'utiliser H2O pendant la combustion comme dissipateur thermique. Le flux produit permet de (1) maintenir la puissance fournie de combustion, (2) d'engendrer des procédés de recyclage d'énergie et (3) d'engendrer un procédé efficace de stockage d'énergie, tandis que la température de la combustion est régulée (4), ce qui permet de refroidir le moteur. Le flux représente une source d'énergie réutilisable dans l'évacuation, à la fois de l'énergie cinétique disponible et de l'énergie thermique disponible. De plus ledit flux est converti en hydrogène et/ou oxygène.
Patent BG-62972-B1 (BG)
Title: 7 alpha-(epsilon-aminoalkyl)-estratrines, method for their preparation, pharmaceutical preparations containing them and their application for the preparation of medicamentous forms
Inventor: BOHLMANN ROLF
IPC: C07J53/00
Filed: 1999-02-16
Abstract: The compoundns can be applied for the preparation of medicamentous forms designed for tumour and hormonal therapy. They show very strong antistrogenous effect. Part of them are pure antiestrogens, and another part have partial estrogenous effect. The substituted 7 alpha-(epsilon-aminoalkyl)-estratrines have the formula where the side chain SK means a residue with the formula where m has the value of 4, 5 or 6, n - 0, 1 or 2, x - 0, 1 or 2, A means hydrogen atom or C1-5-alkyl group, B and D are always a hydrogen atom, or C1-5-alkyl group, B & D are always a hydrogen atom, or A & B together mean alkylene group -(CH2)p-c, p is 2,3,4 or 5 and D is hydrogen atom, or A & D together mean alkylene group -(CH2)q- c, q is 2, 3 or 4 and B means hydrogen atom and E is unsubstituted or one or five times fluorinated ethyl residue, or the end substitutent -(CH2)-2-E- of the side chain is optionally substituted by a substituted aryl and heteroaryl residue which is bound directly or by means of mono- di- or trimethylene group to the sulphur atom, R3 means hydrogen atom, carbon residue with up to 8 carbon atoms or residue with the formula where R3' is hydrogen or carbon atom with up to 8 carbon atoms or is phenyl residue, R11 is hydrogen, halogen atom or one nitrooxygroup -O-NO2, R14, R15 alpha,R15 beta, R16 alpha& R16 beta always mean hydrgoen atom or R14 & R15 alpha mean additional bond or methylene bridge, or R15 beta means methylene group and R15 alpha means hydrogen atom, or R15 alpha & R15 beta are alway a methylene group, or R15 beta and R16 beta together form methylene bridge, or R16 alpha or R16 beta means halgen atom or R16 alpha and R16 beta together mean methylidene group and the customary substitutents R14, R15 alpha, R15 beta, R16 alpha and R16 beta are always hydrogen atom, R17' means hydrogen atom in alpha- or beta- position means C1-5-alkyl, C2-5-alkylene or C2-5-alkynyl group or is trifluoromethyl group and R17" is hydrogen atom or residue with formula in which R17''' is hydrogen atom or carbon residue with up to 8 carbon  atoms, or when R17' is in alpha- position, R17', together with R14 form ethanol bridge provided that A & B simultaneously do not mean -(CH2)p or A & D togehter do not mean -(CH2)q, at least one substituent of R11, R14, R15 alpha, R15 beta,R16 alpha & R16 beta is not a hydrogen atom. The invention also relates to the physiologically aceptable adjunctive salts of the compounds with organic and inorganic acids. 42 claims, 1 figure
Patent CH-718048-B1 (CH)
Title: Mécanisme de chronographe pour pièce d'horlogerie.
Inventor: PIERRE-YVES GRÜRING
IPC: G04F7/08
Filed: 2020-11-13
Abstract: L'invention concerne un mécanisme de chronographe (1) pour mouvement d'horlogerie, comprenant : – un premier compteur (5) d'une première unité de temps agencé pour être en liaison cinématique débrayable avec un mouvement de base ; – un deuxième compteur (7) d'une deuxième unité de temps en liaison cinématique avec ledit premier compteur (5) par l'intermédiaire d'un engrenage réducteur (9). Selon l'invention, ledit engrenage réducteur (9) comprend un réducteur cycloïdal disposé collatéralement à chacun dudit premier compteur (5) et dudit deuxième compteur (7).
Patent CU-24267-B1 (CU)
Title: Conjunto de recipiente para líquidos, tales como bebidas y aceites, que comprende un recipiente, campanas y conjunto de válvula
Inventor: HANSSEN HUBERT JOSEPH FRANS
IPC: B65D21/02
Filed: 2013-07-22
Abstract: <p>La invención se refiere a un conjunto (1) de recipiente para líquidos tal como bebidas y aceites, que comprende un recipiente (2), cantos de los extremos o campanas (4, 6B) y un conjunto (3) de válvula para alimentar un propulsor y surtir el líquido desde el contenedor (2). Una porción (4) del conjunto (1) tiene una sección transversal poligonal, cuya sección transversal al menos circunscribe parcialmente la(s) sección(es) transversal(es) del resto del conjunto (1).</p>
Patent CU-24526-B1 (CU)
Title: Compuestos inhibidores de los receptores endosomales tipo peaje
Inventor: ALPER PHILLIP
IPC: C07D471/04
Filed: 2017-09-06
Abstract: <p>La invención descrita en la presente se refiere a compuestos 4, 5, 6, 7-tetrahidro-1 H-pirazolo[4,3-c]piridinilo y compuestos 4, 5, 6, 7-tetrahidro-2H-pirazolo[4,3-c]piridinilo de la Fórmula (A), que actúan en la inhibición de receptores endosomales tipo Peaje para tratar enfermedades autoinmunes.</p> <p>ESPACIO PARA FÓRMULA</p>
Patent EP-1026178-B1 (EP)
Inventor: ESSELBORN EBERHARD
IPC: C09D7/45
Filed: 2000-01-22
Granted: 2004-03-17
Abstract: Amine oxide group-containing maleic anhydride copolymers, obtained by reacting at least 1 mol% of the anhydride groups with a primary/tertiary diamine and then oxidizing the tertiary amino groups to form amine oxide groups attached to the polymer chain by half-amide and/or imide groups.  Amine oxide group-containing maleic anhydride (MA) copolymers, obtained by (a) reaction of at least 1 mol% of the anhydride groups in MA copolymers with diamines of formula (I), followed by (b) oxidation to form amine oxide groups attached by half-amide and/or imide groups of formula (II) and/or (III).  R<1> = H or 1-24C hydrocarbyl;  R<2> = 2-24C alkylene;  R<3>, R<4> = 1-12C (preferably 1-6C) aliphatic and/or alicyclic alkyl groups.
Patent EP-1040922-B1 (EP)
Inventor: STAHL DIETMAR
IPC: B41F35/04
Filed: 2000-03-10
Granted: 2003-05-07
Abstract: An apparatus and method for removing and cleaning ink from an ink fountain in a rotary printing press. The ink fountain includes an ink fountain container having a fountain roll disposed adjacent an open side thereof. The apparatus includes a scraping device for forcing ink from the container in the direction of the inking roll, and a metering device disposed between the container and fountain roll which is movable to an open position to form a gap between the fountain roll and container through which ink forced by the scraping device is directed into an underlying catching trough. The container further includes a doctor blade positionable into adjacent relation to the fountain roll for removing ink from the fountain roll during a cleaning operation and directing the removed ink into the catching trough so as to preclude contamination of the downstream roll train of the inking unit.
Patent EP-1062943-B1 (EP)
Inventor: GERS-BARLAG HEINRICH DR
IPC: A61Q1/02
Filed: 2000-05-15
Granted: 2008-01-09
Abstract: Cosmetic or dermatological light-protecting composition (A) contains boron nitride (I) and an ultra-violet (UV)-filter substance (II) that includes a triazine structural motif.  An Independent claim is included for use of boron nitride to improve the skin feel of UV-filter compositions containing triazine derivatives.
Patent EP-1164135-B1 (EP)
Inventor: RONCUCCI GABRIO
IPC: A61P9/00
Filed: 2000-06-15
Granted: 2004-02-18
Abstract: The present invention is directed to metal-phthalocyanines of general formula (I) <CHEM> to the corresponding conjugates, the processes for their preparation and use in the photodynamic therapy of microbial infections (viral, bacterial and mycotic), tumor, pre-cancerous and proliferative pathologies and/or in the diagnosis, as well as for blood and blood derivatives sterilization.
Patent EP-1136655-B1 (EP)
Inventor: TOMLINSON LEROY OMAR
IPC: F01K19/00
Filed: 2000-11-22
Granted: 2007-04-18
Abstract: In a combined cycle system having a multi-pressure heat recovery steam generator (30), a gas turbine (14) and steam turbine (18), steam for cooling gas turbine components is supplied from the intermediate pressure section of the heat recovery steam generator supplemented by a portion of the steam exhausting from the HP section of the steam turbine, steam from the gas turbine cooling cycle and the exhaust from the HP section of the steam turbine are combined for flow through a reheat section (50) of the HRSG. The reheated steam is supplied to the IP section inlet (22) of the steam turbine. Thus, where gas turbine cooling steam temperature is lower than optimum, a net improvement in performance is achieved by flowing the cooling steam exhausting from the gas turbine and the exhaust steam from the high pressure section of the steam turbine in series through the reheater of the HRSG for applying steam at optimum temperature to the IP section of the steam turbine. <IMAGE>
Patent EP-1083244-B1 (EP)
Inventor: BARBEZAT GERARD
IPC: C23C4/11
Filed: 2000-07-17
Granted: 2003-09-10
Abstract: Aluminum oxide-based layer applied on a substrate by plasma spraying has a thickness of more than 0.3 mm and is built up in a sandwich fashion to form a lamella. The aluminum oxide layers are placed between two intermediate layers of a ceramic material which increases the volume on cooling by phase conversion.
Patent EP-1084049-B1 (EP)
Inventor: VALENTINI LEONARDO
IPC: B60K6/28
Filed: 2000-01-12
Granted: 2003-07-02
Abstract: The invention relates to a hybrid propulsor with braking energy recovery, particularly for motorcycles, comprising a four stroke engine (1), a reversible electric engine (4), coupled with said four stroke engine by synchronised couplings (3), energy accumulation means (7, 8), coupled with said reversible electric engine (4), a processor (5) and a control circuit for the propulsor operation.
Patent EP-1166026-B1 (EP)
Inventor: SYMONDS KEITH THOMAS
IPC: B01J19/24
Filed: 2000-02-24
Granted: 2006-12-20
Abstract: A fluid mixing means comprising a bonded stack of plates, the stack comprising in series a plurality of passageways for a first coolant or heating fluid stream, one or more first perforated plates (170) for providing a plurality of passageways to receive a reactant fluid, one or more second perforated plates (120) for providing a plurality of passageways (105, 124) in which catalytic material is packed to receive a process fluid and a plurality of passageways for a second coolant or heating fluid characterised in that the reactant fluid passageways and process fluid passageways are connected thereby to mix the reactant fluid and process fluid in the presence of a catalyst and in temperature controlled conditions.
Patent EP-1151298-B1 (EP)
Inventor: BARBERA-GUILLEM EMILIO
IPC: G01N33/567
Filed: 2000-01-13
Granted: 2008-09-17
Abstract: A method for screening for a pro-tumor immune response according to the present invention, the method comprises: contacting a clinical sample with one or more detector molecules for detecting, and then determining the amount of, mononuclear cell phenotype in the sample; and (b) comparing the amount of mononuclear cell phenotype determined in the sample to a reference value for the mononuclear cell phenotype; wherein a significant difference in the amount of mononuclear cell phenotype determined as compared to the reference value may be an indicator of the presence of a pro-tumor immune response. Also provided are assay kits for determining an amount of mononuclear cell phenotype in performing the methods according to the present invention.
Patent EP-1161499-B1 (EP)
Inventor: TRESCH RAINER
IPC: C09B45/28
Filed: 2000-02-28
Granted: 2003-12-03
Abstract: Azoxy dyes of the general formula I in the form of the free acid where n is 0 or 1, each R<SUP>1 </SUP>is selected from the group consisting of methoxy, hydroxyl and carboxyl, each R<SUP>2 </SUP>is selected from the group consisting of carboxyl, amino, C<SUB>1</SUB>-C<SUB>4</SUB>-alkylamino, allylamino, benzylamino and methoxycarbonylmethylamino, and the phenyl rings A may additionally be substituted by C<SUB>1</SUB>-C<SUB>8</SUB>-alkyl, unsubstituted or methyl- or halogen-substituted phenyl, hydroxyl, amino, nitro, halogen, carboxyl, N-benzylcarbamoyl, unsubstituted or nitro-, halogen-, C<SUB>1</SUB>-C<SUB>4</SUB>-alkoxy- or acetoxy-substituted phenylcarbamoyl and naphthylcarbamoyl or be benzofused, their copper complexes, a process for preparing the copper complex dyes, azoxy dyes of the formula I in their partially or completely deacylated form, their copper complexes, colorants comprising these azoxy dyes and/or their copper complexes and also their use for dyeing and printing natural or synthetic substrates.
Patent EP-1180319-B1 (EP)
Inventor: SCHACK GOERAN
IPC: H04R1/10
Filed: 2000-03-06
Granted: 2003-09-10
Abstract: The invention relates to an adjustable brace (1) comprising a pair of resilient elements (2, 3) which are interconnected at the ends (4, 5). The resilient elements are curved so that one element (2) is predominantly positioned externally in the brace, while the other element (3) is predominantly positioned internally in the brace. Means (6) are provided to cooperate with both elements between their ends to adjust the distance between the elements. If the means are affected in a direction toward each other, e.g. halfway along the brace, tensile forces will be generated in the internal element and compressive forces in the external element and the resulting force will cause the brace to curve additionally. The field of use is preferably for braces which are to extent behind the ear to hold a loudspeaker, side bars of a pair of glasses, etc. which are to be adapted to an individual anatomy.
Patent EP-1196455-B1 (EP)
Inventor: GIARDELLO MICHAEL A
IPC: C09J151/06
Filed: 2000-02-04
Granted: 2008-01-16
Abstract: The invention discloses an adhesion agent composition comprising at least one C3-C200 olefin compound having at least one metathesis active double bond, wherein the olefin is substituted or unsubstituted; and at least one compatibilizing functionality for interacting with a substrate surface. The substrate surface can be any surface, for example, silicate glasses, silicate minerals, metals, metal alloys, ceramics, natural stones, plastics, carbon, silicon, and semiconductors. The invention also discloses articles of manufacture utilizing these adhesion agents as well as methods for adhering a polyolefin to a substrate surface.
Patent EP-1171190-B1 (EP)
Inventor: SCHULMAN JOSEPH H
IPC: A61N1/375
Filed: 2000-03-22
Granted: 2011-05-04
Abstract: A ceramic case assembly, and method of making a ceramic case assembly for a micro-stimulator includes the use of a cylindrical or tubular ceramic case (22). A metal band (28) is hermetically bonded to one end (24) of the ceramic case by brazing forming a ceramic case housing assembly for a micro-stimulator. In another embodiment, the metal band is jointed to the ceramic case with a step joint or angle joint for self-jigging. In another embodiment, a metal band is attached to each end of the ceramic case.
Patent EP-1210144-B1 (EP)
Inventor: SEN LUYI
IPC: A61N1/30
Filed: 2000-04-17
Granted: 2008-09-03
Abstract: An array is placed in contact with or close proximity with an organ or tissue surface to cause electroporation for gene, protein, drug delivery in both ex vivo and in vivo applications. A low DC voltage with a short pulse duration, and long burst pulse is applied to the array. A long rest period is provided between pulse bursts to allow for cell recovery. To enable the application of a low voltage shock in a large organ with same transfection efficiency, four gene, protein and drug delivery systems are illustrated.
Patent EP-1194915-B1 (EP)
Inventor: HATJASALO LEO
IPC: G02B27/42
Filed: 2000-05-19
Granted: 2004-09-29
Abstract: The invention relates to a light panel, comprising a light source (1) and a panel element (2). The panel element is manufactured from a substantially transparent material for transmitting light thereby. The panel element (2) is further configured as a waveguide panel, inside which the light beams propagate with total reflection and get outcoupled therefrom with a diffractive outcoupling system. An outcoupling system (2u), such as a grating structure or the like, is adapted to cover the entire panel element (2) as far as its light surface (2a) is concerned, such that divergent recesses and/or grooves of various sizes and/or shapes are used to produce divergent local gratings of various sizes and/or shapes, such as multi-shaped and/or binary pixels and/or units, having the filing factor, shape, profile and/or size thereof optimized in such a way that the diffraction efficiency is a function of place.
Patent EP-1185242-B1 (EP)
Inventor: HANKE BERNHARD
IPC: A46D1/00
Filed: 2000-06-09
Granted: 2005-08-31
Abstract: An anti-microbial body care cosmetic composition comprising in the part contacting the human or animal skin and/or mucosa and organic matrix containing homogeneously dispersed particles of a metallic silver having a particle size in the range of 1 to 50 nm (silver nanoparticles) in an amount providing on the surface of said part and anti-microbially effective but less than cytotoxic silver concentration.
Patent EP-1189936-B1 (EP)
Inventor: PROUD CHRISTOPHER GREGORY
IPC: A61K38/00
Filed: 2000-06-21
Granted: 2006-11-29
Abstract: We claim a therapeutic method of inducing programmed cell death comprising administering to a recipient a peptide of 10-25 amino acids, comprising the sequence: (KR)xxYxxx(F/Q)L(L/M) wherein x is any amino acid.
Patent EP-1191942-B1 (EP)
Inventor: NEILSON LORNA
IPC: C12Q1/68
Filed: 2000-06-29
Granted: 2004-01-21
Abstract: This invention provides methods for diagnosing and treating endometriosis, and promoting implantation of an embryo. The methods involve determining or modulating antileukoprotease activity in a subject.
Patent EP-1196523-B1 (EP)
Inventor: AUBAY ERIC
IPC: C08F220/34
Filed: 2000-06-19
Granted: 2004-09-15
Abstract: This invention relates to a cleaning composition comprising at least one surfacatant or at least one cosmetic vehicle and a water-soluble or water-dispersible copolymer comprising, in the form of polymerized units: (a) at least one monomer compound of general formula I: (b) at least one hydrophilic monomer carrying a functional group with an acidic nature which is copolymerizable with (a) and which is capable of being ionized in the application medium; (c) optionally at least one hydrophilic monomer compound with ethylenic unsaturation with a neutral charge, carrying one or more hydrophilic groups, which is copolymerizable with (a) and (b).
Patent EP-1214074-B1 (EP)
Inventor: GILES FRANCIS J
IPC: A61K45/06
Filed: 2000-09-22
Granted: 2004-06-16
Abstract: Viral infections selected from the group consisting of herpes simplex virus, varicella zoster virus, respiratory syncytial virus and cytomegalovirus can be treated by administering to the host a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof; wherein Y, Ra, and R1 are as defined herein. The compounds and salts can also be used to inhibit viral replication of these viruses in cells.
Patent EP-1146761-B1 (EP)
Inventor: IWAMURA MIKIO
IPC: H04W48/16
Filed: 2000-09-29
Granted: 2013-06-19
Abstract: In a mobile communications system, its power consumption and time required for a mobile station to carry out neighboring cell search are reduced, and the complicated process involved in system design and management is simplified. A method is proposed of searching for a neighboring cell by using grouped channel identifiers sent from the sectors to the mobile station in the mobile communications system that allows the mobile station communicating with a plurality of base stations to decide sectors the mobile station waits for or communicates with. It includes the step of assigning channel identifiers belonging to the same group to sectors of the same base station, and the step of sending from the base station to the visiting mobile station a notification of any one of the channel identifiers assigned to the sectors of one of neighboring base stations. <IMAGE>
Patent EP-1247165-B1 (EP)
Inventor: RIPLEY JOHN
IPC: G06F17/30
Filed: 2000-10-02
Granted: 2006-05-03
Abstract: The present invention comprises a computer-implemented method for transforming data in a relational database to a hierarchical database. It comprises creating an import map that maps each relational database field to a hierarchical field in the hierarchical database using a relational database schema and a hierarchical database schema, using the import map to import data from the relational database; and transforming the relational data into hierarchical documents. The method further comprises creating a hierarchical database schema that corresponds to the relational database schema. The hierarchical documents may be stored in computer memory or on disk.