baber/WOPTO huggingface dataset:
Patent DO-P2016000042-A (DO)
Title: Anticuerpos contra el inhibidor del activador de plasminógeno tipo 1 (pai-1) y usos de los mismos
Inventor: PHILIP JANIAK
IPC: C07K16/38
Filed: 2016-02-03
Abstract: LA INVENCIÓN PROPORCIONA ANTICUERPOS QUE SE UNEN ESPECÍFICAMENTE AL INHIBIDOR DEL ACTIVADOR DE PLASMINÓGENO DE TIPO 1 (PAI-1). LA INVENCIÓN TAMBIÉN PROPORCIONA COMPOSICIONES FARMACÉUTICAS, ASÍ COMO ÁCIDOS NUCLEICOS QUE CODIFICAN ANTICUERPOS ANTI-PAI-1, VECTORES DE EXPRESIÓN RECOMBINANTES Y CÉLULAS HOSPEDANTES PARA PREPARAR TALES ANTICUERPOS, O FRAGMENTOS DE LOS MISMOS. TAMBIÉN SE PROPORCIONAN MÉTODOS DE USO DE ANTICUERPOS PARA MODULAR LA ACTIVIDAD DE PAI-1 O DETECTAR PAI-1, YA SEA IN VITRO O IN VIVO. ADEMÁS LA DESCRIPCIÓN PROPORCIONA MÉTODOS DE PRODUCCIÓN DE ANTICUERPOS QUE SE UNEN ESPECÍFICAMENTE A PAI-1 EN EL ESTADO CONFORMACIONAL ACTIVO.
Patent DO-P2017000035-A (DO)
Title: Inhibidores de la proteina quinasa c y metodos de su uso
Inventor: MICHAEL JOSEPH LUZZIO
IPC: C07D413/14
Filed: 2017-02-03
Abstract: Se divulgan inhibidores de la PKC. Los inhibidores de la PKC son útiles para el tratamiento de enfermedades asociadas con PKC, incluyendo algunos tipos de cáncer. Los inhibidores de la PKC tienen eficacia mejorada en cantidades de dosis más bajas para lograr la regresión del tumor, potencia mejorada, perfil PK, absorción, tolerancia gastrointestinal y selectividad de quinasa.
Patent DO-P2018000138-A (DO)
Title: Nuevos anticuerpos anti-claudina y sus métodos de uso
Inventor: SARAH FONG
IPC: C07K16/30
Filed: 2018-06-01
Abstract: En la presente se proveen nuevos anticuerpos y conjugados de anticuerpo y fármaco anti-CLDN (ADC), incluyendo a derivados de los mismos, y métodos para usar los mismos para tratar trastornos proliferativos.
Patent EC-SP11005642-A (EC)
Title: Nuevos pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinas
Inventor: GUZI TIMOTHY J
IPC: A61K31/519
Filed: 2011-09-01
Abstract: En sus muchas realizaciones, la presente invención provee una nueva clase de compuestos de pirazolo [1,5-a] pirimidina como inhibidores de las quinasas dependientes de ciclina, métodos para preparar dichos compuestos, composiciones farmacéuticas que contienen uno o más de dichos compuestos, métodos para la preparación de formulaciones farmacéuticas que comprenden uno o más de dichos compuestos, y métodos para el tratamiento, prevención, inhibición, o mejoría de una o más enfermedades asociadas con las CDK usando dichos compuestos o composiciones farmacéuticas.
Patent EC-SP13012490-A (EC)
Title: Ánodo para protección catódica y método para producirlo
Inventor: MOJANA CORRADO
IPC: C23F13/10
Filed: 2013-03-15
Abstract: Está descrito un ánodo metálico para protección catódica en forma de cinta de red que tiene mallas cuyos agujeros tienen forma romboidal, caracterizado por tener dichos agujeros de forma romboidal dispuestos con la diagonal mayor orientada según la dirección de la longitud de la cinta y porque las orillas laterales a lo largo de la longitud de la cinta están desprovistas de protuberancias cortantes. Está también descrito un método para obtener dicho ánodo.
Patent EC-SP13013043-A (EC)
Title: Composición oral líquida que comprende sodio divalproex y proceso para preparar la misma
Inventor: SAHANA DIPAK
IPC: A61K31/19
Filed: 2013-11-25
Abstract: La presente invención se dirige a una composición oral, líquida de sabor agradable, que comprende sodio de divalproex, y a un proceso para preparar la misma. Particularmente, la presente invención se refiere a una composición oral, líquida, estable, tal como una solución que comprende sodio de divalproex y a un proceso para preparar la misma.
Patent EG-24866-A (EG)
Title: Method and device for reducing the content of NOx and N20 in gases
Inventor: SCHWEFER MEINHARD
IPC: B01J8/00
Filed: 2003-06-14
Granted: 2010-11-02
Abstract: To reduce the content of NO 2 and NOx in process and exhaust gases, they are passed over two catalyst beds (4,5) in succession, containing one or more zeolites charged with iron, between the gas inflow (1) and outflow (2). An agent for the reduction of NOx is fed (3) into a mixer (6) between the catalyst beds, and the bed temperatures are set at = 500 [deg] C. The gas pressure is adjusted to at least 2 bar in both beds. The spatial speed is selected through the ring channel gaps (7-10) at the beds, so that the NO 2 content is degraded in the first bed at the most by 90 % of its content on the entry of the gas into the bed and is degraded in the second bed by at least 30 % of the content on entering the second bed.
Patent GB-189701871-A (GB)
Title: Improved Method and Means for connecting Tubes and Pipes of Stoneware, Earthenware, and Glass.
Inventor: DOUCEDE AMBROISE EDOUARD
Filed: 1897-01-23
Granted: 1897-11-27
Abstract: 1871. DoucÞde, A. E. Jan. 23. Sleeve joints for stoneware, earthenware, or glass pipes. A metal sleeve c is provided with internal ribs d for centering it on the pipe ends, which must be of equal diameter. After the sleeve has been placed in position, cement is poured into the space between it and the pipes. A number of patterns of distance-pieces d, both detached from and fixed to the sleeve c, are shown in the Specification. Fig. 14 shows the sleeve with a central flange n against which the pipe ends 1, 2 are butted, so as to ensure that the joint shall come accurately in the middle of the sleeve.
Patent GB-189701969-A (GB)
Title: An Improved Method and Means for Fastening or Jointing Boxes and Packing Cases.
Inventor: BORHAM THOMAS ALBERT
Filed: 1897-01-25
Granted: 1897-12-18
Abstract: 1969. Borham, T. A. Jan. 25. Fastenings for boxes. Lugs 4 on the rear of the lid engage under lugs 4<a> on the rear of the case, and the lugs 4 on the front of the lid abut on the lugs 4<a> on the front of the case, the latter being tapped to receive a screw &c. 5. If desired, all the lugs may be tapped.
Patent GB-189703095-A (GB)
Title: An Improved Liquid Food.
Inventor: SELLMAN WILLIAM
Filed: 1897-02-05
Granted: 1897-05-22
Abstract: 3095. Sellman, W. Feb. 5. Food preparations.-A liquid food is composed of eggs, lemons, oranges, cereals, extracts of meat and poultry, cream, milk, honey, and brandy or other vinous liquid. Half the eggs are laid in a pan and covered with the peel and juice of the lemons ; the other half are then placed on the lemon peel and orange juice added, together with salt. After standing for seven days, sugar is added, and subsequently extracts of meat and poultry. Crushed cereals are then stirred in, and milk, cream, honey, and cognac incorporated with the mass.
Patent GB-189704569-A (GB)
Title: Improvements in Stoppering Bottles.
Inventor: HEINEMANN JOHANN FRIEDRICH ERN
Filed: 1897-02-19
Granted: 1897-10-30
Abstract: 4569. Heinemann, J. F. E. G. Feb. 19. Bottle necks. - Relates to internally - stoppered bottles, the neck being formed without an internally-projecting shoulder, and of such a diameter that, on re moving the washer b, the internal stopper a can also be removed from the bottle.
Patent GB-189704618-A (GB)
Title: A New Medium for and Improvements in Decorating Surfaces.
Inventor: WILLIAMS WILLIAM GEORGE
Filed: 1897-02-20
Granted: 1897-12-24
Abstract: 4618. Williams, W. G., and Taylor, S. Feb. 20. Ornamenting.-Sheets or articles of celluloid, xylonite, or similar transparent or semi-transparent material, either plain or coloured, are coated with gold or other leaf, bronze or glass powder, pearl or metal particles, paint, or varnishes, or printed, stencilled, or painted ornamentally, and used for ornamenting surfaces.
Patent GB-189710517-A (GB)
Title: Improvements in Apparatus or Machinery Used in Coating Metal Sheets with Metals or Alloys.
Inventor: HONHORST JOSEPH LAWRENCE
Filed: 1897-04-27
Granted: 1897-06-19
Abstract: 10,517. Honhorst, J. L., and Lloyd, R. J. April 27. Tinning, galvanizing, &c.-The rolls are so mounted that the pressure is constant no matter what thickness of sheet may be treated. Fig. 1 shows a perspective view of rolls and supports. The journals a of the rolls A rest on removable bearings carried on a frame a<4>. In order to press the rolls together, upright arms C pivoted at their lower ends are employed. They are pulled against the journals by the weights D.
Patent GB-189714491-A (GB)
Title: Improvements in Apparatus for Preventing Fraudulent Alteration of Cheques, Drafts, and the like.
Inventor: FELL JOHN CORRY
Filed: 1897-06-15
Granted: 1897-07-31
Abstract: 14,491. Fell, J. C., [Wesley Manufacturing Co.]. June 15. Cheques, drafts, and the like.-An apparatus for perforating cheques, drafts, and the like, in order to prevent fraudulent alteration, is shown in section in Fig. 2. Sets of needles c<5> are secured to a rotary disc c<3> forming part of a head C which is mounted upon a sliding rod B normally kept in the raised position by a spring c<4>. The edge of the disc c<3> is formed with notches which engage with the edge of a plate-spring a<7> secured to the base A of the apparatus ; by this means the disc is free to move vertically, but the plate-spring tends to prevent its rotation. The rod B is fitted within a circular aperture in a column forming part of the base, and its lower reduced end carries a washer b<2> and serves as a stop for a lever a<16> which is pivoted at a<17> to the base. The free end of the lever a<16> serves as a pawl which engages with a ratchet-wheel a<10> mounted upon a pin a<8>; this pin also carries a. wheel a<9> which is in contact with a wheel a<12> mounted upon a frame a<13> and pressed downwards by a spring. A cheque, draft, or the like is placed between the wheels a<9> and a<12>, after the latter has been raised by hand, and the disc c<3> is turned until the desired set of needles is over an ink pad a<5> fitted within the base. The knob c<2> is next depressed, and the pins are forced through the cheque &c. and into the ink pad ; on releasing the knob the pins are raised and the cheque &c. is pushed therefrom by a fixed plate a<6>, the punctures being at the same time inked. The paper is fed forwards by the wheels a<12>, a<9>, which are driven by means of the ratchet-wheel a<10> and lever a<16> as the latter moves downwards with the rod B. The lever a<16> can move, to a slight extent, laterally as well as vertically, and is drawn against the ratchetwheel a<10> by a spring.
Patent GB-189717855-A (GB)
Title: Improvements in Furnaces.
Inventor: ASHLEY HOWARD MATRAVERS
Filed: 1897-07-30
Granted: 1898-07-09
Abstract: 17,855. Ashley, H. M. July 30. Smoke consuming; firebridges; dampers. - Relates t o improvements on the invention described in Specification No. 16,644, A.D. 1890. In order to prevent the flame from impinging directly on the crown plate, the outer end of the passage between the bridges A and B is turned parallel with the furnace by bending over the edge of the front bridge A. The air supply to the ashpit is regulated by a door G held open by a rack H, and the supply above the grate is regulated by a plate F which carries a hit-and-miss ventilator, and which is pulled into the open position shown after firing ; horns g, having adjustable screws, serve to regulate the amount of opening. The blocks at the ends of the firebars, instead of being chamfered off, are elongated, in order to give the air a longer passage through them.
Patent GB-189720640-A (GB)
Title: Improvements in or relating to a Combination Matchbox and Cigar-cutter.
Inventor: BONDY BERTHOLD
Filed: 1897-09-08
Granted: 1897-10-30
Abstract: 20,640. Bondy, B. Sept. 8. Smokers' combination articles.- The drawer c of a match box is divided by a partition e into two compartments f, g for cigar ends and matches respectively. A cutter d is carried by the drawer and slides beneath an aperture b in the outer case a.
Patent GB-189721358-A (GB)
Title: A Duplex Comb for Mounting and Retaining Ladies' Hair.
Inventor: HERRICK SETH WATSON
Filed: 1897-09-17
Granted: 1898-03-19
Abstract: 21,358. H e rrick, S. W., a n d Lunger, C. R. Sept. 17. Combs, hair; hair slides.-A duplex comb for dressing I a d i e s' hair is in two parts A, B, held together b the arms 3 fitting into the grooves 2.
Patent GB-189724173-A (GB)
Title: Improvements in or relating to Children's Cots with Sliding Side Rails or Sides.
Inventor: PEYTON BERNARD RICHARD
Filed: 1897-10-19
Granted: 1898-09-03
Abstract: 24,173. Peyton, B. R., and Pitt, J. Oct. 19. Cots.-The pillars of the cot are slotted at a<1>, a<2>, or are made in two parts. The top and bottom bars of the side frames project at b<1>, b<2> into the slots a<1>, a<2>, so that the frames can be raised or lowered. Catches c serve to hold the frames in the top position.
Patent GB-189726412-A (GB)
Title: Improvements in Electrical Transformers.
Filed: 1897-11-12
Granted: 1898-02-26
Abstract: 26,412. British Thomson-Houston Co. and Hobart, H. M. Nov. 12. Transformers are wound so as to allow free ventilation and also heavy insulation at the ends of the layers. Figs. 1 and 2 show sectional v i e w s. Corner pieces Care arranged a the corners of the core L, and then a few turns of bare copper strips to serve as the secondary are wound on. A ventilating-space I is thus left between the core and the coil. A layer of insulating-material is then placed in position and the primary coils P wound on, there being one or more fewer turns at the ends on each successive layer. The insulating-layers D, D<1> project beyond the coils, and the insulation is thickened. Finally, one or two layers of the secondary S' may be wound over the primary.
Patent GB-189800507-A (GB)
Title: Improvements in Bread Making Machinery.
Inventor: WATSON WILLIAM
Filed: 1898-01-07
Granted: 1899-01-07
Abstract: 507. Watson, W. Jan. 7. Moulding dough.-The oven floor is made movable, and is run beneath a cylinder from which the dough is expressed by a piston. The strips of dough so formed are dusted, divided, glazed, and fed into the oven. Fig. 1 shows one arrangement. The hopper A contains the dough, which is fed into the cylinder B when the latter is moved beneath it, the piston C being first raised out of the way by the double rack c, c'. In the bottom of the cylinder are openings b through which the dough is fed on to the travelling oven bottom g. The strips of dough are dusted from a box D, and are then divided by the rotary or reciprocating blades at H. The loaves are brushed by the brush I and washed at K. A slide E, fitted with openings of any desired shape, is arranged below the cylinder to control the flow of dough.
Patent GB-189801378-A (GB)
Title: Improvements in the Process of Manufacturing Cements.
Inventor: JUSTICE PHILIP MIDDLETON
Filed: 1898-01-18
Granted: 1898-03-26
Abstract: 1378. Justice, P. M., [Lithosite Manufacturing Co.]. Jan. 18. Paints, materials for.-Cements are described stated to be applicable as paints when ground very fine and mixed with water. The mother liquor of sea-water is evaporated down, magnesium oxide mixed with the strong solution of magnesium chloride so obtained, and the evaporation continued at a higher temperature. The resulting material is mixed with calcined magnesite, and ground to form the cement. Commercial chloride of magnesium may be used, oxalic acid or its salts being used to neutralize the calcium chloride it contains. Pulverized burnt clay may be added to the magnesium chloride. An alternative method of making the cement is to add boracic acid to the mother liquor, and, after evaporating down, to grind the product direct with calcined magnesite. Suitable colouring-matters may be added.
Patent GB-189801966-A (GB)
Title: Improvements in Window Frames and Sashes.
Inventor: GAMMIE JAMES
Filed: 1898-01-25
Granted: 1899-01-25
Abstract: 1966. Gammie, J. Jan. 25. Windows. - The lower portions B' of the pulley stiles B, with the parting and inner beads C, D, are made detachable to facilitate the removal of the sashes from the frame for the purpose of cleaning the outside of the glass &c. The movable parts B<1> of the stiles are secured to the fixed parts B, or to the sash stiles A<1>, by pivoted or spring catches J, which enter recesses in the stiles B<1>, A<1>. Fig. 3 shows a method of securing the sash cords or chains F to the sash stiles A so as to allow the sash to turn when it is removed from the frame. The end of the cord is threaded through a hole in a tube or thimble H which is made large enough to receive the knot, and is arranged to slide in a socket I in the centre of the sash stile. A flange at the end of the thimble limits the motion of the thimble within the socket.
Patent GB-189802621-A (GB)
Title: Improvements in Mats or Bandages for Stopping Leaks in Vessels.
Inventor: SULTEMEYER CARL FRIEDRICH
Filed: 1898-02-01
Granted: 1898-03-19
Abstract: 2621. Sultemeyer, C. F. Feb. 1. Leaks, stopping. -A mat for this purpose consists of two parts, the inner of which is formed with flaps 10 stiffened by frames, while to the outer are attached ribs 12. In operation, the rush of water entering the breach acts on the flaps 10, thus unrolling the mat. The two layers of the mat are disconnected in their upper parts, so that the loose end of the inner layer may be dropped down, if desired, to engage more closely with the breech in the hull.
Patent GB-189804197-A (GB)
Title: Improvements in Driving Mechanism for Bicycles, Tricycles and the like.
Inventor: PURDON HENRY ARTHUR
Filed: 1898-02-19
Granted: 1898-04-09
Abstract: 4197. Purdon, H. A., and Walters, H. E. Feb. 18. Driving-mechanism for bicycles, tricycles, &c. The gearing is constructed so that the pedals describe the vertically-elongated path shown in Fig. 1. Treadle-levers a, a<1> pivoted, one a on a cranked pin f secured to the chain-wheel g, and the other a<1> on a double crank f keyed to the usual crank axle, are extended rearwards and slide in grooves c pivoted to triangular frames d, pivoted to the frame at e. Links h connect the corners k of the frames d to the cranks f as shown. In a modification, the frames d are replaced by a single bar sliding horizontally in guides secured to the chain stays. In this case, the links h are pivoted on the same pins as the levers a, a<1>.
Patent GB-189804250-A (GB)
Title: Improvements in or relating to Shoots for the Delivery of Flour, Grain, or other Pulverized or Granular Materials, or the like.
Inventor: HALL DANIEL
Filed: 1898-02-21
Granted: 1899-01-14
Abstract: 4250. Hall, D., and Kay, J. H. Feb. 21. Grain bins.-Specification No. 21,497, A.D. 1896, is referred to. The bin, according to the present invention, consists of a tall chamber a above a trough a<1> from which the front portion, accessible through a flap b, is divided off by a partition a<3> and a sliding door e. The chamber is formed with vertical ribs a<4> which are connected by stays k.
Patent GB-189806773-A (GB)
Title: Improvements in and relating to Street Lanterns for the Reception of Incandescent Electric Lamps.
Inventor: STEWART JOHN EDWIN
Filed: 1898-03-21
Granted: 1899-01-28
Abstract: 6773. Stewart, J. E. March 21. Supporting lamps for street lighting. One or more incandescent lamps are attached by a coupling to a joint-piece L. This is connected by a bent copper tube K<1> with an upright tube in a supporting-post A, the conductors being passed through these tubes. An opal cover G rests on a ring E, of T-section, carried by three supports D on a ring B, which is bolted to the post. The cover is held under a rubber ring in a cap H, attached to the jointpiece L by a bayonet-joint. Ornaments may be applied, such as a band surrounding the ring E. The invention is applicable especially in place of gas lamps on existing posts.
Patent GB-189809568-A (GB)
Title: Improvements relating to the Formation of Tubes or Cases of Paper or the like.
Inventor: BOULT ALFRED JULIUS
Filed: 1898-04-26
Granted: 1899-04-26
Abstract: 9568. Boult, A. J., [Stecher Lithographic Co.]. April 26. Drawings to Specification. Paper tubes.-Relates to improvements on the inventions described in Specification No. 5610, A.D. 1896. In that Specification apparatus is described for forming paper tubes or shells from blanks and then for collapsing them along the scored or creased joints to facilitate the folding along these joints afterwards. In the present Specification the tubes are carried along by bands to allow the glass or paste thoroughly to dry before the tubes are passed through the collapsing or re-folding devices. From the latter the tubes are carried between roll cutters by which they are cut into suitable lengths. Suitable hook and gripping &c. devices are used in connection with the bands to feed and deliver the tubes, and straightening-devices are used to bring the tubes into the desired position between the cutters.
Patent GB-189809961-A (GB)
Title: Improvements in or relating to Machinery for Providing Cigarettes with a Reinforcement or Mouth-end.
Inventor: BEEMAN JOSEPH SAMUEL
Filed: 1898-04-30
Granted: 1898-11-26
Abstract: 9961. Beeman, J. S. April 30. Cigarette - m a k i n g machines; cigarettes.- Machines for r e i n - forcing the mouthpiece ends of cigarettes by removing the tobacco for a short distance and inserting a rolled - up piece of paper, cork, &c. in its place. Fig. 1 shows a plan view of the machine with the feeding - hopper removed. The cigarettes are fed one by one to a trough J<2> from which a plunger K transfers them to one of the tubular holders G<5> carried by the frame G, ejecting at the same time a finished cigarette. The frame G is rotated step-by-step by friction between it and flat springs G<1> mounted on a disc G<2>, which is secured by a spring G<3> to a collar G<4> on the shaft U. The frame turns one step each time the catch S is released by the action of the cam D<3> and lever S<2>. A cam D' acting on the roller H<3> pushes the carrier frame G to the right, and a rapidly-rotating fork on the screw L breaks out the tobacco at one end. The loose fragments of tobacco are blown out by an air blast from a rubber bulb N, the jet of air issuing at N<2>. At the next step the paper strip, which has been fed in at O<3>, seized by a split tube O<1> and rolled around it, and kept from.uncoiling by the finger O<14>, is placed in the end of the cigarette wrapper now free from tobacco, and a stage later the roll of paper is pushed home by the pressure of the right-hand face of the frame G against a spring-controlled flat-headed pin. A device is provided for locking the frame G in position after each partial revolution
Patent GB-189812766-A (GB)
Title: Improved Pocket Inhaler or Vaporizer.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1898-06-07
Granted: 1898-08-06
Abstract: 12,766. Thompson, W. P., [Kellogg, J. H.]. June 7. Inhalers.-A pocket inhaler for applying vaporizable medicaments to the nose, throat, and internal ear consists of a tubular body or mouthpiece A connected with a nose piece B and compressible air bulb C by means of two flexible tubes D and E. The mouthpiece A is packed with a roll of absorbent material F saturated with the liquid medicament, and has an opening at each end, one of which is fitted with a screw plug 2 furnished with nipples 3 and 4 for attachment of the flexible tubes.
Patent GB-189815090-A (GB)
Title: Improvements in or connected with Waste Water and other Closets.
Inventor: ALLEN WILLIAM THOMAS
Filed: 1898-07-09
Granted: 1899-04-08
Abstract: 15,090. Allen, W. T. July 9. Traps for closets. The basin or extension pipe in waste-water closets is seated in a funnel-shaped vessel a made with projecting and radial ribs d to prevent stoppage ; or the top may be corrugated with the same object. The inlet to the trap b may also be funnel-shaped ; or the trap may be choked at b<2>.
Patent GB-189817096-A (GB)
Title: An Improved Valve for Inflating Cycle Tyres.
Inventor: MAGNEY FRITZ
Filed: 1898-08-08
Granted: 1898-09-17
Abstract: 17,096. Magney, F., and Plange, E. Aug. 8. Tyres, pneumatic.- Relates to inflating- valves for cycle tyres. A loose nipple b is inserted in the upper end of a valve casing a, a tight joint being made by a collar b<2> and the cap c. At the lower end of the passage b<1> is formed a seat b<4> for the valve f, which is held by a cup g the stem g<1> of which fits tightly within the spring e. Specification No. 28,133, A.D. 1897, is referred to.