baber/WOPTO huggingface dataset:
Patent PT-1590324-E (PT)
Title: Novel heteroaryl-substituted acetone derivatives as inhibitors of phospholipase a sb 2 /sb
Inventor: LEHR MATTHIAS
IPC: C07D207/325
Filed: 2004-02-06
Abstract: The invention relates to novel heteroaryl substituted acetone derivatives which inhibit the enzyme phospholipase A2, pharmaceutical preparations containing these compounds and a method of producing these compounds.
Patent PT-1635855-E (PT)
Title: Selective r-cadherin antagonists and methods
Inventor: FRIEDLANDER MARTIN
IPC: C07K/
Filed: 2004-04-30
Abstract: An isolated peptide useful as a selective antagonist of mammalian R-cadherin comprises 3 to 30 amino acid residues, three contiguous residues of the peptide having the amino acid sequence Ile-Xaa-Ser; wherein Xaa is an amino acid residue selected from the group consisting of Asp, Asn, Glu, and Gln. Preferably Xaa is Asp or Asn. In one preferred embodiment the peptide is a cyclic peptide having 3 to 10 amino acid residues arranged in a ring. The selective R-cadherin antagonist peptides of the invention are useful for inhibiting the targeting of stem cells, such as endothelial precursor cells, to developing vasculature, for inhibiting R-cadherin mediated cellular adhesion, and for inhibiting retinal angiogenesis.
Patent PT-1968779-E (PT)
Title: Method of adhesively bonding a strip of flexible fabric to a substrate
Inventor: MERCIER PASCALE
IPC: B29C65/50
Filed: 2006-11-17
Abstract: The invention relates to a method of bonding a strip of flexible sheet onto at least one flexible or rigid support, said sheet and said support including at least one continuous fine metal foil sandwiched and bonded between two fiberglass fabrics. In accordance with the invention, the method includes a step of pressing said strip of flexible sheet against the support by means of a press while simultaneously heating said strip for at least a portion of the duration over which pressure is applied.
Patent PT-2204383-E (PT)
Title: Processes for preparing eptifibatide and pertinent intermediate compounds
Inventor: HO GUOJIE
IPC: C07D213/71
Filed: 2005-04-08
Abstract: The present invention provides, inter alia, convergent processes for preparing eptifibatide that involve coupling a 2-6 eptifibatide fragment to an activated cysteinamide residue to form a 2-7 eptifibatide fragment, attaching a mercaptopropionic acid residue to the 2-7 eptifibatide fragment through disulfide bond formation, coupling the peptide intramolecularly, and removing the protecting group, to form eptifibatide. The invention further provides products produced by the described processes, novel compounds that can be used as synthetic intermediates for the preparation of eptifibatide, and novel compounds that are structurally similar to eptifibatide.
Patent PT-2281944-E (PT)
Title: Rotary drier for plants for the production of bituminous macadams with the use of recycled materials
Inventor: MAMMOLI FABIO
IPC: E01C19/00
Filed: 2009-07-09
Abstract: A rotary drier for plants for the production of bituminous macadams with the use of recycled materials comprises a hollow rotary cylinder (2), heating means (9) connected to one end (4) of the cylinder (2), an aggregates infeed section (7) connected to one end of the cylinder (2), a dried material outfeed section (8) connected to the other end and an insertion section (24) for inserting recycled cut material into the cylinder (2), the insertion section being connected to an intermediate portion of the cylinder (2). The insertion section (24) comprises a plurality of radial openings (31) distributed circumferentially on the cylinder (2) inner surface (18) and covered by a covering structure (33) which also comprises a plurality of separator plates (34) circumferentially distributed along the cylinder (2) inner surface (18) so that between each pair of adjacent separator plates (34) there is at least one radial opening (31), the separator plates forming a plurality of first channels (35) for guided insertion of the cut material into the cylinder (2). There are also means (32) for feeding the cut material to the openings (31), said means being located on the outside of the cylinder (2). The covering structure (33) is fastened to the cylinder (2) inner surface upstream of the openings (31), extending in the material feed direction and is distanced from the cylinder (2) inner surface (18) downstream of the openings (31) for putting the openings (31) in communication with the inside of the cylinder (2).
Patent PT-2491644-E (PT)
Title: System and method for offsetting the input voltage unbalance in multilevel inverters or the like
Inventor: MALDINI GIORGIO
IPC: H02M7/487
Filed: 2010-10-12
Abstract: The system for offsetting the input voltage unbalance in multilevel inverters or the like comprises a control unit operatively associated with a multilevel inverter for converting direct current into alternate current, the control unit being suitable for piloting the multilevel inverter for generating an output current depending on a reference current, and an equalisation unit for equalising the input voltages of the multilevel inverter having first generation means of a harmonic component of order equal to the reference current, out of phase with respect to the fundamental component of the reference current, detection means of the unbalance of the input voltages to the multilevel inverter, regulation means of the amplitude of the harmonic component depending on the detected unbalance, for offsetting the unbalance. The method for offsetting the unbalance of the input voltages in multilevel inverters or the like comprises a control phase of a multilevel inverter for converting direct current into alternate current, in which the multilevel inverter is piloted for generating an output current depending on a reference current, a generation phase of a harmonic component of order equal to the reference current, out of phase with respect to the fundamental component of the reference current, a detection phase of the unbalance of the input voltages to the multilevel inverter and a regulation phase of the amplitude of the harmonic component depending on the detected unbalance, for offsetting the unbalance.
Patent PT-728207-E (PT)
Inventor: HARLEY CALVIN BRUCE
IPC: C12Q1/68
Filed: 1994-11-10
Abstract: Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps.
Patent PT-800692-E (PT)
Inventor: JEFFREY LACE J
IPC: B60R25/00
Filed: 1995-12-26
Abstract: An anti-theft vehicle system for a vehicle wheel having a rotational axis includes at least one inhibitor disposed within the vehicle wheel to selectively engage the vehicle wheel to prevent the vehicle wheel from rotating about its rotational axis. The anti-theft vehicle system also includes rotatable means disposed within the vehicle wheel and cooperating with the inhibitor for moving the inhibitor between an engaged position and a disengaged position with the vehicle wheel.
Patent PT-738722-E (PT)
Inventor: BOTTCHER HENNING
IPC: C07D307/85
Filed: 1996-04-11
Abstract: 5-(Amino or piperazino)-benzofuran-2-carboxamides (I) are new. 5-(Amino or piperazino)-benzofuran-2-carboxamides of formula (I) and their salts are new. R1 = NH2, or piperazino; R2 = H, Cl, Br, OH, or OA; X = CONR4R5, or CO-Het; R4, R5 = H, A, or benzyl; A = 1-4C alkyl; and Het = imidazol-1-yl, triazol-1-yl or tetrazol-1-yl. An Independent claim is also included for the preparation of (I).
Patent PT-769348-E (PT)
Inventor: VIANELLO FORTUNATO
IPC: C03C19/00
Filed: 1996-10-14
Abstract: The device for removing coatings from the surface of a glass plate (1) comprises at least one head (10) which is movable along the rim portion (12) of the glass plate (1), and at least one motorized tool (32a) provided at the head (10). The tool (32a) is of the cup-shaped type and has an active flat surface (39) for treating the coatings (3). The tool (32a) is contacting the glass plate coating (3) on an annular portion of the flat surface (39) thereof. <IMAGE>
Patent PT-902727-E (PT)
Inventor: OLLIVIER JAMES
IPC: B01J23/94
Filed: 1997-05-13
Abstract: PCT No. PCT/FR97/00847 Sec. 371 Date Mar. 26, 1999 Sec. 102(e) Date Mar. 26, 1999 PCT Filed May 13, 1997 PCT Pub. No. WO97/44131 PCT Pub. Date Nov. 27, 1997The invention features a method for treating a supported catalyst with a sulphur compound based active phase and a mercury compound contaminated mineral support. This method consists in implementing the following steps: the said catalyst is contacted with a basic aqueous solution of at least one sulphide selected among alkaline metal sulphides, alkaline-earth metal sulphides or ammonium sulphide; then the catalyst is separated from the basic aqueous solution. At the end of this process, the treated catalyst shows the same characteristics as before its contamination by mercury.
Patent PT-966485-E (PT)
Title: Mutated nonactivating igg2 domains and anti-cd3 antibodies incorporating the same
Inventor: TSO J YUN
IPC: A61K38/00
Filed: 1997-05-19
Abstract: The invention provides mutated IgG2 constant regions and anti-CD3 antibodies incorporating the same. Such antibodies specifically bind to the CD3 antigen on T-cells but induce reduced mitogenic response compared with otherwise identical antibodies bearing natural IgG2 constant regions. The antibodies can be used for treating disorders requiring immune suppression with fewer side effects than result from treatment with prior anti-CD3 antibodies.
Patent PT-857607-E (PT)
Inventor: DARLEY BILLY F
IPC: E05G7/00
Filed: 1998-01-13
Abstract: Device for transporting valuables, characterised in that it consists at least of a vehicle (2) which is provided with a loading space (3) with containers (4) for valuables (5) which can be taken up therein, removed therefrom respectively, and means to take up said containers (4) in the loading space (3) and remove them therefrom respectively. <IMAGE>
Patent PT-975771-E (PT)
Title: Type ii tgf-beta receptor/immunoglobulin constant region fusion proteins
Inventor: GOTWALS PHILIP
IPC: C12N1/15
Filed: 1998-04-16
Abstract: Fusion proteins comprising the TGF-beta Type II receptor linked to a portion of an immunoglobulin constant chain are described. Also described are methods of using the fusion proteins of the invention to treat a variety of fibroproliferative disorders.
Patent PT-1003525-E (PT)
Inventor: PHILLIPS NIGEL C
IPC: A01N63/00
Filed: 1998-08-05
Abstract: A composition (A) for inducing a response in the cell of an animal comprises: (a) a mycobacterial DNA (B-DNA); and (b) a first carrier. - Independent claims are also included for: (1) a method (AA) for using the composition (A) to induce a response in the cell of an animal; (2) a method (BB) for inducing a caspase activity in cells of an animal, by administering a composition (B) comprising: (a) a mycobacterial composition M-DNA, and (b) a first carrier which is Mycobacterium phlei cell wall; and (3) composition (B).
Patent PT-1051174-E (PT)
Inventor: DEBREGEAS PATRICE
IPC: A61K31/44
Filed: 1998-08-10
Abstract: The invention concerns omeprazole microgranules each comprising an active layer containing the active principle, and an outer gastroprotecting layer containing a gastroprotecting agent, characterized in that the omeprazole is combined with at least a hydrophobic substance.
Patent PT-1105102-E (PT)
Inventor: ALEMAN CLAUDE LE LOGIS DES PIN
IPC: A61K47/10
Filed: 1999-08-18
Abstract: The invention concerns an aqueous pharmaceutical composition containing a lyophilisate consisting of clopidogrel or ticlopidin optionally in the form of a pharmaceutically acceptable salt, of Pluronic F683reconstituted in a recovery solvent comprising a basic pH modifying agent compatible with parenteral administration and Solutol HS153.
Patent PT-1109782-E (PT)
Inventor: SJOGREN MAGNUS
IPC: C07D205/04
Filed: 1999-08-27
Abstract: There is provided a process for the production of a N-protected azetidine-2-carboxylic acid, which process comprises the steps of: (a) addition of base to an aqueous solvent comprising an organic acid addition salt of an azetidine-2-carboxylic acid; and (b) addition of protecting agent to the resultant reaction mixture.
Patent SG-34491-G (SG)
Title: Method of operating apr valve wellbore
IPC: E21B49/08
Filed: 1991-05-07
Abstract: A two-position annulus pressure responsive valve is used for well testing or treatment by running it into a wellbore with the valve in a first valve position (eg. open), increasing the wellbore pressure without cycling the valve to its second valve position, decreasing the pressure and cycling the valve to its second valve position (eg. closed) in response to said reduction in pressure. In the method, the string may be automatically filled, a packer may be pressure tested without cycling the valve, and fluids may be spotted into the testing string, displacing wellbore fluids from the bottom of the testing string, prior to running the test.
Patent IE-810234-L (IE)
Title: Shampoo composition
IPC: A61K8/49
Filed: 1981-02-06
Abstract: Antidandruff, lotion shampoo compositions which contain 11% to 20% of anionic surfactant, 4% to 6% of suspending agent selected from ethylene glycol esters and alkenol amides of C16-C22 fatty acids and C16-C22 alkyl dimethyl amine oxides, and 2% to 4% of an alkanol amide of C8-C14 fatty acids.
[EP0034846A2]
Patent IE-890374-L (IE)
Title: Anhydrides in detergent compositions
IPC: C11D3/39
Filed: 1989-02-06
Abstract: The present invention relates to a detergent composition in aqueous solution comprising,   (i) a surfactant selected from anionic, nonionic, zwitterionic and cationic surfactants and mixtures thereof, (ii) a precursor compound capable of giving rise to a peroxygen compound in the presence of water, (iii) a bleach activator capable of enhancing the bleaching activity of the peroxygen compound so formed,   (iv) a suds suppressing agent and   (v) a detergent builder, characterised in that the bleach activator comprises one or more cyclic anhydrides containing at least one nitrogen atom in the alpha position with respect to at least one of the carbonyl functions in the anhydride and the activator is at least partially soluble in water. These compounds show bleaching activity at relatively low temperatures.
Patent IE-790636-L (IE)
Title: Aluminium monoethylphosphite.
IPC: C07F9/141
Filed: 1979-08-08
Abstract: Aluminum monoethyl-phosphite, useful for the protection of plants against fungal diseases, is manufactured in a continuous manner by first preparing a mixture of phosphite compounds, containing at least 70 mol % of diethyl phosphite, then saponifying and neutralizing such mixture with an inorganic base, at a temperature of 20 DEG -85 DEG C., at a pH of 4.0-8.5, and finally reacting the residual aqueous solution of alkaline metal monoethyl-phosphite, continuously withdrawn from the preceding operation, with an approximately stoichiometric amount of a water-soluble aluminum salt at 70 DEG -95 DEG C. and a pH of 3.0-4.5.
[US4272448A]
Patent IE-900749-L (IE)
Title: A yeast processing system
IPC: C12N15/31
Filed: 1990-03-02
Abstract: A polypeptide for production in yeast comprises a fusion of a signal peptide, a leader peptide and a heterologous protein or polypeptide. The polypeptide is modified in its amino acid sequence adjacent to a yeast processing site positioned between the C-terminal end of the leader peptide and the N-terminal end of the heterologous protein so as to provide a presentation of the processing site which makes it accessible to proteolytic cleavage. Such a presentation is provided by adding one or more amino acids (at least one of which is negatively charged) to either the C-terminal end of the leader or the N-terminal end of the protein, or both. The heterologous protein may, for instance, be aprotinin or insulin precursor or an analogue thereof.
[WO9010075A1]
Patent IE-40619-L (IE)
Title: Device for continuous release of active agent into an¹aqueous environment
IPC: A61M35/00
Filed: 1974-04-11
Abstract: 1425550 Fertilizer composition ALZA CORP 9 April 1974 [25 April 1973] 15673/74 Heading C1B [Also in Division A5] Monobasic ammonium phosphate is ground to an average particle size of 40 microns and mixed with plasticized polyvinylchloride extruded through a die to form a continous rod which is coated with an impermeable coating and chopped into pieces which are capable of imbibing water through the cut ends and gradually releasing fertilizer over a period of hours (Example 7).
[GB1425550A]
Patent FI-832355-L (FI)
Inventor: DE CLERCQ ERIK DESIRE ALICE
IPC: C07D473/34
Filed: 1983-06-28
Abstract: Compounds of the general formula(wherein X represents an oxygen or sulphur atomR' represents a hydroxy or amino groupR<sup>2</sup> represents a hydrogen atom or a group of formula -CN<sub>2</sub>OR<sup>3</sup><sub>a</sub>and R<sup>3</sup> and R<sup>3</sup><sub>a</sub> which may be the same or different, each represents an amino acid acyl radical) and physiologically acceptable salts thereof are useful for the treatment if viral infections and have been found to have a surprisingly high water-solubility which renders them of value in the formulation of aqueous pharmaceutical preparations. Processes for preparing the compounds are described.
Patent IE-32327-L (IE)
Title: Ladder construction
IPC: E06C1/02
Filed: 1968-09-10
Abstract: Ladder construction in which a relatively thick-walled ferrule blank on sleeve is either press fitted upon, or loosely telescopes on, the end portion of a rung and crimped into engagement with the rung. The run end portion with the blank is then projected through a pierced side rail and formed in die members which move axially w.r.t. the blank and shear an outer portion of the blank wall away from the inner portion. The outer portion is formed into flanges which tightly engage the side rail. The blank is pref. al (alloy). Possible to use a ferrule blank having circular surface and non-circular bore whereby a non-circular rung can mounted in a circular opening in the side rail, as the is the easiest configuration to make and a circular form cavity in the die can readily be made by simple machine.
[DE1803917B2]
Patent IE-871585-L (IE)
Title: Nitrofurantoin dosage form.
IPC: A61P31/04
Filed: 1987-06-15
Abstract: The invention involves a combination sustained release/rapid release pharmaceutical capsule for oral administration of nitrofurantoin comprising, in a capsule shell, a first layer of a first particulate mixture comprising nitrofurantoin, polyvinylpyrrolidone and carboxyvinylpolymer; and a second layer of a second particulate mixture comprising macrocrystalline nitrofurantoin.
[EP0250023A1]
Patent IE-37019-L (IE)
Title: Safety device
IPC: B60R21/2346
Filed: 1972-12-18
Abstract: A safety device with an inflatable cushion for moving vehicles, particularly automobiles, comprises at least one inflatable cushion, means for expanding and re-expanding the said cushion and a collision detector controlling the actuation of such a device, the cushion being equipped with means for transferring gas in both directions, at two different flow rates, between the surrounding atomosphere and the inside of the cushion, the gas exchange taking place at a low flow rate in the direction from the inside of the cushion to the surrounding atmosphere, for the purpose of deadening the person to be protected when the latter is thrown against the said cushion during an accident, and at a higher flow rate in the direction from the surrounding atmosphere to the inside of the cushion for the purpose of rapidly re-inflating the said cushion as soon as the latter is no longer acted upon by the person to be protected. The device is particularly effective in case of a series of impacts, because it is partially reversible and dissipates a part of the energy by absorbing gas and absorbing the rest of the energy to restore the device to its initial state before a new deadening of the person to be protected.
Patent IE-881852-L (IE)
Title: Producing laminated material
IPC: B29C65/00
Filed: 1988-06-17
Abstract: A method of and apparatus for dynamically mechanically bonding together a plurality of laminae, at least one of which comprises thermoplastic material: for example, polyethylene. In one aspect of the invention the laminae are forwarded in face to face relation through a pressure biased nip between a patterned nip defining member and an opposing nip defining member (eg, a relief patterned cylinder and an anvil cylinder) which members are independently driven to maintain a predetermined surface velocity differential between them. In another aspect of the invention which is particularly useful at intermediate and higher line velocities --preferably for line velocities of about 300 feet or more per minute and, more preferably, for line speeds of about 450 feet or more per minute -- the nip defining members say be operated with equal surface velocities. In each of these aspects of the invention, the members may be biased towards each other to provide a predetermined pattern-element-psi loading; and, additionally, they may be independently heated to provide each with an elevated surface temperature which is, preferably, in a predetermined range below the melt temperature of the thermoplastic lamina disposed closest to or in contact with each respective nip defining member as the laminae are forwarded through the nip. <IMAGE>
Patent IE-891907-L (IE)
Title: (+) 1-£(3,4,5-TRIMETHOXY)¹-BENZYLOXYMETHYL|-1-PHENYL-N,N-DIMETHYL-n-PROPYLAMINE, ITS¹PROCESS OF PREPARATION AND ITS THERAPEUTIC USE
IPC: C07C217/48
Filed: 1989-06-13
Abstract: (+)-1-[(3,4,5-Trimethoxy)benzyloxymethyl]-1-phenyl- N,N-dimethyl-n-propylamine of formula <IMAGE> is a medicament which is useful in gastroenterology.h
Patent IE-902002-L (IE)
Title: Novel treatment of reversible obstructive airways disease
IPC: A61K31/40
Filed: 1990-06-05
Abstract: Compounds of formula (I), wherein R<1> and R<2> together represent two vicinal hydrogen atoms, or form a second bond between the vicinal carbon atoms to which they are attached; R<3> represents H, OH, alkoxy or protected hydroxy; R<4> represents OH; R<5> represents H, alkyl or alkenyl; R<6> and R<7> independently represent O, (H,OH), (H,protected hydroxy) or (H,alkoxy); X and Y independently represent O, (H,OH) or (H,H); n is 1 or 2; or pharmaceutically acceptable derivatives thereof; are provided for the treatment of reversible obstructive airways disease, particularly asthma. Compositions containing such compounds are also disclosed.
Patent IE-39927-L (IE)
Title: Substituted indanones.
IPC: C07C49/613
Filed: 1974-10-03
Abstract: [1-oxo-2-aryl- or -thienyl-2-subst.-5-indanyloxy-(or -thio)]- alkanecarboxylic acids and their derivatives of the formula I <IMAGE> in which the substituents are defined in Claim 1, are prepared. Appropriate 2-aryl- or 2-thienyl-2-subst.-5-hydroxy-(or -mercapto)-1-indanones are reacted with a haloalkanoic acid or an ester thereof. The said compounds are present as the free acid or as alkyl esters, and they can be converted, if they are an acid, into the corresponding esters, salts and amides. The said compounds and also their salts, esters and amides are useful diuretic and saluretic agents and can be used in medicaments, preferably for the treatment of hypertension.
[GB1474459A]
Patent IE-45792-L (IE)
Title: Flameproofed compositions
IPC: C08K3/22
Filed: 1977-10-10
Abstract: Polyamides flameproofed with red phosphorous and including cadmium oxide as an additive to retard the formation of phosphine during heating are disclosed. The polyamides are particularly useful in the manufacture of electrical components. (From US4187207 A) [FR2367100A1]