Patent SG-11201908784T-A (SG)
Title: Improved antigen binding receptor formats
Inventor: KLEIN CHRISTIAN
IPC: A61K39/395
Filed: 2018-03-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT (51) International Patent Classification: A61K 39/395 (2006.01) C07K 14/735 (2006.01) (71) Applicant all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse A61K 35/17 (2015.01) C07K 16/28 (2006.01) 124, 4070 Basel (CH). C07K 14/725 (2006.01) C07K 16/30 (2006.01) C07K 14/705 (2006.01) A61K 39/00 (2006.01) (71) Applicant (for US only): HOFFMANN-LA ROCHE (21) International Application Number: INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- PCT/EP2018/057567 sey 07424 (US). omit VIII °nolo olo VIII lII 1111111 ow (10) International Publication Number WO 2018/177967 Al (22) International Filing Date: 26 March 2018 (26.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17163090.8 27 March 2017 (27.03.2017) EP 17171775.4 18 May 2017 (18.05.2017) EP (72) Inventors: KLEIN, Christian; c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). MOESSNER, Ekke- hard; c/o Roche Glycart AG, Wagistrasse 18, 8952 Sch- lieren (CH). DAROWSKI, Diana; c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). STUBENRAUCH, Kay-Gunnar; c/o Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg (DE). (74) Agent: BRODBECK, Michel; Grenzacherstrasse 124, 4070 Basel (CH). (54) Title: IMPROVED ANTIGEN BINDING RECEPTOR FORMATS Figure 1A Figure 1B Figure 1C linker VL CL linker VH VH CH CH VH CH ATM CSD SSD VL CL VL CL ATM CSD SSD ATM CSD SSD 1-1 N 1-1 00 1-1 O Fab Format Fab Format VL-CL-ATM scFab Format ATM = anchoring transmembrane domain; CSD = co-stimulatory signaling domain ; SSD = stimulatory signaling domain (57) : The present disclosure generally relates to antigen binding receptors in new formats capable of specific binding to a tumor associated antigen. More precisely, the present invention relates to an antigen binding receptor which efficiently and specifically binds to/interacts with an antigen on the surface of a tumor cell, and to a T cell transfected/transduced with the antigen binding receptor. Furthermore, the invention relates to nucleic acid molecules and vectors encoding antigen binding receptors of the present invention. The invention also provides the production and use of T cells in a method for the treatment of particular diseases as well as pharmaceutical compositions/medicaments comprising antigen binding receptors and/or T cells of the present invention. [Continued on next page] WO 2018/177967 Al IMEDIMOMMIONE1013010BEHOHNEMOVOIMIE (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))