baber/WOPTO huggingface dataset:
Patent JP-2001521377-A (JP)
IPC: A61K35/39
Filed: 1998-03-16
Abstract: A method for stimulating pancreatic cells to synthesize and/or excrete insulin comprises contacting insulin-producing cells, in particular their aqueous suspension, with a water-soluble cellulose derivative, in particular selected from alkylated, hydroxyalkylated, and alkylated-hydroxyalkylated cellulose or a mixture thereof. A medium for the culture of pancreatic beta-cells contains an effective cell-stimulating amount of a cellulose derivative. It can be used to stimulate pancreatic beta-cells to produce and/or excrete insulin. An apparatus for such stimulation comprises a container holding a solution of a cellulose derivative in an aqueous culture medium. Stimulation of pancreatic beta-cells by a cellulose derivative is useful in the management of diabetes. Further preservative or therapeutic methods using the aqueous cellulose derivatives are disclosed.
Patent JP-H11512642-A (JP)
Title: １対の弾性化された脚開口を有しているパンツ式衣類を製造するための連続高速方法
IPC: A61F5/44
Filed: 1997-05-07
Abstract: (57)【要約】
複数の引っ張られているガータを有している基材からパンツ式衣類を製造する為の方法。ガータは、弾性材料、あるいは弾性帯と１つ又はそれ以上の柔軟な裏打ちシートとの積層、のあらゆる連続ループである。１つの実施例においては、基材が、引っ張られているガータがその上に付けられている１つ又はそれ以上のマンドレルに接合されている。基材材料はガータのループの中から取り除かれ、これによって基材内に開口が形成される。基材は、その長手方向縁を合わせるように、その長手方向中心線に沿って折り畳まれる。基材は次に、その接合線に沿って接合され、そして基材は個々のパンツ式衣類へと切断される。好ましい実施例においては、基材の長手方向縁に対し弾性を与え、これによって弾性化されたウエストバンドを製造する為の工程が含まれている。
Patent JP-2001518216-A (JP)
Title: バスを終端する方法及び装置
IPC: G06F13/40
Filed: 1998-03-27
Abstract: (57)【要約】
ＳＣＳＩポート（２６，２８）を有するＳＣＳＩバス（２５）を終端する方法及び装置が開示されており、該ＳＣＳＩポート（２６，２８）が、広口ＳＣＳＩバス（２５）だけに関連された複数の入力／出力端子から成る第１入力／出力端子セットと、広口ＳＣＳＩバス（２５）及び細口ＳＣＳＩバス（２５）の双方に関連された複数の入力／出力端子から成る第２入力／出力端子セットとを有する。本方法は、第１基準信号が前記第１入力／出力端子の内の１つの端子上に存在するかを決定する段階と、第２基準信号が前記第２入力／出力端子の内の１つの端子上に存在するかを決定する段階と、（１）もし、前記第１基準信号決定段階で第１基準信号が検出されず、且つ、（２）もし、前記第２基準信号決定段階で第２基準信号が検出されたならば、前記第２入力／出力端子の全ての端子を終端しない一方で、前記第１入力／出力端子の各端子を終端する段階と、の諸段階を含む。
Patent JP-2000512417-A (JP)
Title: フィーチャ・カードのコンピュータへの非破壊的活状態挿入およびコンピュータからの非破壊的活状態取外しを可能にする方法およびシステム
IPC: G06F13/40
Filed: 1997-04-08
Abstract: (57)【要約】
システム・バスを介して転送される制御信号をアクティブ信号レベルに駆動するか、あるいはダウン・レベル・アクティブ制御信号を接地レベルに近いロー信号レベルに駆動することによって、挿入可能フィーチャ・カード（ＦＣ）（３４−３７）の活状態挿入および活状態取外しを行う間、システム・バス（３２）の状態を制御する方法。この機構によって、システム・バスは、信号妨害の影響を受けないようになり、それによって、システム・リセットやデータの完全性の低下などシステムに悪影響を及ぼさずに、挿入可能ユニットの活状態挿入および活状態取外しを行うことを可能にする。活状態挿入または活状態取外しの間に、活状態挿入バス・コントローラ（ＬＩＢＣ）（３０）は、ＦＣの活状態挿入または活状態取外しが行われていることを、ＦＣに関連する活状態挿入機構から通知された後、システム・バス・コントローラ（ＳＢＣ）（３３）とのインタフェース（３８）を介してシステム・バスにアクセスする。ＬＩＢＣ（３０）によってシステム・バス・アクセスが行われ、ＬＩＢＣ（３０）がシステム・バスの制御を得た後、ＬＩＢＣは、制御信号のシステム・バス・セットのサブセットを、挿入／取外し信号妨害の影響を受けない状態に駆動する。これと並行して、ＬＩＢＣ（３０）は、現在ＳＢＣ（３３）によって実行されているタイムアウト動作およびウォッチドッグ動作を中断する。挿入プロセスが完了したことがＬＩＢＣ（３０）に通知されると、ＳＢＣ（３３）は再びシステム・バスの制御を得る。ＦＣを取り外す場合にも同じ手順ステップが実行される。
Patent JP-2001507429-A (JP)
Title: パワーテイクオフ動作中のエンジン速度を制御する方法および装置
IPC: F02D41/04
Filed: 1999-02-26
Abstract: (57)【要約】
パワーテイクオフ（ＰＴＯ）動作の間におけるエンジン速度を制御する方法および装置である。ＰＴＯ動作のアクセル・ペダル・オーバーライドをイネーブルする技術を開示し、これにおいて、アクセル・ペダル誘起のエンジン速度値がプリセットのＰＴＯエンジン速度にまで減少したときに、ＰＴＯ動作を再開させる。また、高速ガバナを用いることにより、ＰＴＯオーバーライド動作の間においてアクセル・ペダルに基づくエンジン速度を制限し、これにより最大エンジン速度を制限するようにする。本発明によれば、車両のオペレータは、これによりエンジンをアクセル・ペダルの作動を介して加速して、プリセットＰＴＯエンジン速度を超える速度まで、ＰＴＯ動作を非係合とせずとも加速することができる。
Patent JP-2000515712-A (JP)
Title: アンテナおよび切換可能な増幅器を有する無線受信サブシステム
IPC: H04B1/18
Filed: 1998-03-25
Abstract: (57)【要約】
周波数同調器を持つ放送受信機ユニット（１２）に作動的に接続し得る無線受信サブシステムは、給電点を持つアンテナ（１４），本質的に給電点に設けられた増幅器（２０），アンテナの給電点および増幅器から放送受信機ユニットの信号入力（１０）まで延びる送信線（１６、４０）を持っている。送信線は１組の導体（２４、２６）、たとえば同軸導体を持っている。手動で操作するスイッチ（２８）が導体にＤＣ電圧をかけるために送信線に設けられており、一方、リレースイッチ（２２）は電圧に応じて増幅器の送信線に対する接続状態を変えるために、送信線に作動的に接続されている。
Patent MD-20000186-A (MD)
Title: Hydrocyclone
Inventor: MAXIMUK PIOTR
IPC: B04C3/06
Filed: 2000-11-27
Abstract: The invention relates to devices for separation of suspensions and may be applied in the food, chemical and other industries. The hydrocyclone contains a body, made in the form of a hollow cylinder, joined in the lower part with a hollow cone, a cover with stuffing box seal, a liquid supply pipe tangentially fixed to the body, pipes for discharge of the purified liquid and of the concentrated mass, respectively, as well as a cone, installed concentric about the cone of the hydrocyclone body, forming an annular channel, communicating with the pipe for discharge of the concentrated mass. Novelty consists in that the pipe for discharge of the purified liquid is provided with a cone, oriented with the smaller base to the pipe for discharge of the concentrated mass, onto the side surface of the cone being executed screw-shaped through windows with screw-shaped plates bulging over them, curved opposite to the liquid movement and forming channels for dispersed and uniform discharge from the inside of the rotatable liquid of the most clarified part thereof, and the cone placed above the pipe for discharge of the concentrated mass is made without detachment bulges and it is installed with the possibility of displacement over the vertical and of fixation in the given position.Claims: 1Fig.: 2
Patent MX-160251-A (MX)
Inventor: KUMAR VIRARAGHAVAN SAMPATH
IPC: G05D7/06
Filed: 1984-07-30
Abstract: A solenoid-operated control valve has a main orifice and a valve member for controlling fluid flow therethrough. A leakage orifice extends through the valve member. A check valve seals the leakage orifice when the main orifice is blocked and moves to open the leakage orifice before the main orifice is opened.
Patent NZ-207912-A (NZ)
Title: Preparing cells enriched in plasmid dna by their differential resistance to radiation
Inventor: MACPHEE D G
IPC: C12N13/00
Filed: 1984-04-19
Abstract: A method for the preparation of plasmid DNA and the expression products thereof. The method provides cells, enriched in plasmid DNA and expression products thereof, which comprise chromosomal DNA which has been substantially degraded by exposing a plasmid DNA-containing organism to an effective dose of ionizing radiation.
Patent NZ-220553-A (NZ)
Title: Papermaking process: addition of polymer to increase drainage rate and fines retention
Inventor: LINHART F
IPC: D21H17/34
Filed: 1987-06-04
Abstract: Paper, board and cardboard are produced by draining a pulp slurry in the presence of high molecular weight, water-soluble polymers of N-vinylamides as drainage aids, retention agents and flocculants. These polymers are particularly effective in a pulp slurry which has a high content of interfering substances and other phenolic compounds.
Patent NZ-222968-A (NZ)
Title: Ethynylheteroaromatic derivatives and medicaments
Inventor: CHANDRARATNA ROSHANTHA A S
IPC: C07D213/80
Filed: 1987-12-17
Abstract: Retinoid-like activity is exhibited by compounds of the formula <CHEM> wherein A is pyridyl, furyl, thienyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, -COOH and its esters, amides and pharmaceutically acceptable salts, -CHO and its acetal derivatives, -COR1 and its ketal derivatives where R1 is -(CH2)nCH3 where n is defined above, or -CH2OH and its ether and acyl ester derivatives; or a pharmaceutically acceptable salt.
Patent NZ-224357-A (NZ)
Title: Oxime-substituted tetrahydropyridine derivatives and pharmaceutical compositions
Inventor: GALLIANI GIULIO
IPC: C07D211/70
Filed: 1988-04-22
Abstract: New compounds (I): <IMAGE> in which R denotes a hydrogen, a hydroxyl or an alkyl containing up to 8 C, optionally substituted by a carboxy or R denotes an aralkyl containing up to 10 C or -COOZ, Z being an alkyl containing up to 8 C or an aralkyl containing from 7 to 10 C, R1 denotes an alkyl containing up to 8 C, R2 denotes a hydrogen or an alkyl containing up to 8 C, -COalk1 or (CH2)2N(alk2)2, alk1 and alk2 denoting an alkyl containing up to 8 C, it being understood that if R denotes an alkyl, R2 does not denote a hydrogen, and their addition salts with acids.
Patent NZ-225748-A (NZ)
Title: Implant injection device
Inventor: SANDOW JURGEN KURT
IPC: A61M31/00
Filed: 1988-08-09
Abstract: The invention relates to a device for the injection of implants, preferably implants "in the form of small rods" (called rods), which are used for the long-term treatment of diseases, whose essential features are the completely transparent construction, especially of the injector body (3), as well as a protecting device which prevents the plunger rod from falling out, and a protective cap (6) for the plunger rod.
Patent NZ-230131-A (NZ)
Title: Excess phytochrome production by transgenic plant
Inventor: HERSHEY HOWARD P
IPC: C12N15/82
Filed: 1989-07-28
Abstract: The preparation of an uninterrupted coding sequence for phytochrome polypeptide, and its incorporation in a recombinant DNA construct containing a constitutive promoter and/or enhancer to transform plants to cause overexpression of phytochrome is described. Methods for preparing such phytochrome coding sequences by deleting the introns from genes derived from monocotyledonous plants are also described. The transgenic plants obtained using such recombinant DNA constructs exhibit a variety of useful agronomic traits.
Patent NZ-240196-A (NZ)
Title: Process for engine sizing paper products comprises adding rosin size and fixing agent to the pulp
Inventor: KROENER MICHAEL
IPC: D21H17/45
Filed: 1991-10-11
Abstract: According to a paper, paperboard and cardboard internal sizing process, resi n size is used, as well as cationic polymers containing polymerized vinylamine units as fixing agents for the resin size.
Patent NZ-255546-A (NZ)
Title: Heat sealing thermoplastics thread to web material
Inventor: VERNON GEOFFREY WILLIAM
IPC: B29C65/00
Filed: 1993-09-10
Abstract: Tags and thread are assembled together for the manufacture of tagged articles such as infusion packets in which each tag is attached to the packet by a length of thread. The thread is held in a looped form between the tag and the packet before use. For the assembly of the tags and thread and to increase the length of thread attaching each tag, means are provided for forming a doubled-over loop that can be trapped between the tag and the packet.
Patent NZ-278313-A (NZ)
Title: Headwear includes a headband and material to cover the head and shoulders attached or attachable to a peak or visor
Inventor: HALL JASON HAMILTON
IPC: A42B1/04
Filed: 1995-01-06
Abstract: PCT No. PCT/AU95/00005 Sec. 371 Date May 17, 1996 Sec. 102(e) Date May 17, 1996 PCT Filed Jan. 6, 1995 PCT Pub. No. WO95/18549 PCT Pub. Date Jul. 13, 1995An article of headwear is provided which includes a substantially forwardly projecting peak or visor, an adjustable head engaging band and a length or sheet of material, the head engaging band being attached or attachable to the peak or visor at or near a rear edge thereof, the length or sheet of material being attached or attachable to the peak or visor and extending rearwardly thereof, whereby the peak or visor may be positioned on a wearer's head such that the material covers the wearer's head and hangs therefrom about the shoulders and neck of the wearer, wherein the head engaging band is positioned about a rear of the wearer's head such that the peak or visor is held in position thereon, and the material has a plurality of fasteners to adjust and fasten the material into a plurality of positions to protect a wearer's neck, head, and/or face.
Patent NZ-328889-A (NZ)
Title: Bird control apparatus simulating a shotgun blast
Inventor: KYLE PETER DESMOND
IPC: A01M29/02
Filed: 1997-10-01
Abstract: Fuel, typically LPG, is ignited in sounding tube 11, and may be activated by remote control or  by a sensor detecting movement of birds in flight.
Patent NZ-335668-A (NZ)
Title: Friction motor crawling along guide wire to position device in target area of lumen
Inventor: RICHTER JACOB
IPC: A61B17/00
Filed: 1999-05-07
Abstract: Motor 1 (typically an oscillating ceramic motor) crawls relative to guide wire 2.  This allows a device to be positioned in a target area of a lumen.
Patent NZ-502784-A (NZ)
Title: Sol-gel coated polarization vessels
Inventor: CATES GORDON D
IPC: G01R33/28
Filed: 1998-08-13
Abstract: A polarization cell for hyperpolarizing a noble gas is described.  The polarization cell is sized and configured to hold a quantity of noble gas an alkali metal and comprises a substrate material with an interior surface coated with a glass coating deposited from a sol-gel.  The sol-gel coating on the substrate is configured to withstand exposures to spin-exchange interactions with optically pumped alkali metal vapor.
Patent NZ-502798-A (NZ)
Title: Capacity affinity sensor
Inventor: BERGGREN CHRISTINE
IPC: C12Q1/6825
Filed: 1998-09-02
Abstract: Described is a capacity affinity sensor for determining the presence of a compound of interest by capacitance measurement.  The sensor is based on self-assembled monolayers on an electrode with immobilized recognition elements available to analytes in the surrounding solution. Additional insulation is provided by auxiliary self-assembled molecules. The sensor has exceptional sensitivity and wide operating range due to these parts of the invention. It is versatile because different kinds of recognition elements can be immobilized directly to the self-assembling monolayer. The electrode then becomes selective to those molecules in the solution.  The analytes that show affinity to the recognition element on the surface being selected. Compared to capacitive sensors described before those described here shows at least a 1000-fold better sensitivity because of the properties of the layer binding the recognition element.
Patent NZ-504266-A (NZ)
Title: A wallboard anchor with hook for fastening objects such as a picture thereto
Inventor: PAUL BERNHARD A
IPC: F16B13/13
Filed: 2000-05-01
Abstract: A rotting rick 1 has comminuted moistened domestic waste 9 stored on air-permeable wood pallets 5 through which air ventilation hoses 4 are passed. Air is drawn to a chimney 3 for ventilating the waste.   A structured layer 13 is applied on the waste, and the height of the rick  does not exceed 2.80m and the width of the rick does not exceed 3m.
Patent NZ-508314-A (NZ)
Title: Pyrrolo[2,3d]pyrimidine compositions and their use
Inventor: CASTELHANO ARLINDO L
IPC: A61P25/00
Filed: 1999-06-01
Abstract: An N-6 substituted 7-deazapurine or pharmaceutically acceptable salts thereof has the formula (I) wherein: R1 and R2 are independently hydrogen or a substituted alkyl, substituted cycloalkyl or optionally substituted aryl wherein only one of R1 and R2 may be hydrogen and when the substituted alkyl is -(CH2)-phenyl or -(CH2-CH2)-phenyl then the phenyl is substituted or R1 and R2 together form an optionally substituted heterocyclic ring, R3 is optionally substituted aryl; R4 is hydrogen or unsubstituted alkyl or optionally substituted aryl and R5 and R6 are independently halogen, hydrogen or an optionally substituted alkyl, aryl, or alkylaryl or R4 and R5 or R5 and R6 together form an optionally substituted heterocyclic or carbocyclic ring. A deazapurine has the formula II wherein: X is N or CR6; R1 and R2 are independently hydrogen or optionally substituted alkoxy, aminoalkyl, alkyl, aryl, or alkylaryl wherein only one of R1 and R2 may be hydrogen or R1 and R2 together form an optionally substituted heterocyclic ring; R3 is optionally substituted arylalkyl, heteroaryl or aryl; R4 is hydrogen; L is hydrogen, optionally substituted alkyl, or R4 and L together form an optionally substituted heterocyclic or carbocyclic ring; R6 is hydrogen, optionally substituted alkyl, or halogen; Q is CH2, O, S, or NR7; R7 is hydrogen or optionally substituted alkyl; and W is optionally substituted alkyl, cycloalkyl, alkynyl, aryl, arylalkyl, biaryl, heteroaryl, substituted carbonyl, substituted thiocarbonyl, or substituted sulphonyl. The compounds are useful for treating a disease or condition associated with increased levels of adenosine in a subject wherein the disease or condition is a central nervous system disorder, a cardiovascular disorder, a renal disorder, an inflammatory disorder, an allergic disorder, a gastrointestinal disorder or a respiratory disorder.
Patent NZ-509576-A (NZ)
Title: FLT3-L mutant polypeptides and nucleic acids and their use in treatment
Inventor: GRADDIS THOMAS J
IPC: C12N15/10
Filed: 1999-06-25
Abstract: A soluble mutant flt3 ligand (flt3-L) polypeptide, wherein said polypeptide exhibits increased or decreased biological activity relative to the full length human wild type flt3 polypeptide (SEQ ID NO:1) or relative to mature human wild type flt3-L polypeptide (SEQ ID NO:18) and wherein said polypeptide comprises a substitution at one or more residues selected from the group consisting of amino acid position 24 of the full length human wild type flt3-L polypeptide (SEQ ID NO:1) and amino acid positions 8-15, 81- 87, and 116-124 of the mature human wild type flt3-L polypeptide (SEQ ID NO:18). Also disclosed is the use of the polypeptide in inducing cellular expansion and/or differentiation and such related medical conditions.
Patent NZ-509600-A (NZ)
Title: Polyketides and their synthesis
Inventor: LEADLAY PETER FRANCIS
IPC: A61P31/04
Filed: 1999-06-29
Abstract: A type I polyketide synthase which comprises a loading module and a plurality of extension modules, wherein said loading module is adapted to load an optionally substituted malonyl and then to effect decarboxylation of the loaded residue to provide a corresponding optionally substituted acetyl residue for transfer to the first of said extension modules, and wherein at least said first extension module is not naturally associated with a loading module that effects decarboxylation; with the proviso that the target polyketide is not a 14-membered macrolide having a 13- methyl group due to incorporation of an (unsubstituted) acetate starter unit.
Patent NZ-520420-A (NZ)
Title: Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors
Inventor: RUECKER CRAIG M
IPC: A23L33/00
Filed: 2001-01-26
Abstract: The present invention provides a process for growing microorganisms which are capable of producing lipids, in particular, lipids containing polyenoic fatty acids. Also disclosed is a process for producing microbial lipids.
Patent NZ-520554-A (NZ)
Title: Tamper-resistant oral opioid agonist formulations
Inventor: OSHLACK BENJAMIN
IPC: A61K9/16
Filed: 2001-02-08
Abstract: Disclosed is an oral dosage form comprising: (i) an opioid agonist in releasable form, and (ii) a sequestered opioid antagonist that is substantially not released when the dosage form is administered intact, such that the ratio of the amount of antagonist released from the dosage form after tampering to the amount of antagonist released from the intact dosage form is about 4:1 or greater, based on the in-vitro dissolution at 1 hour of the dosage form in 900ml of Simulated Gastric Fluid using a USP Type II (paddle) apparatus at 75 rpm at 37 degrees C. The above dosage form provides for methods for preventing abuse of an oral opioid dosage form by having the opioid antagonist interfere with the effect of the opioid agonist if the dosage form is tampered with.
Patent NZ-524690-A (NZ)
Title: Pre-tailed link box for temporary interruption of current flow along cables
Inventor: DOCKRAY JOHN
IPC: H01R13/46
Filed: 2001-09-13
Abstract: A pre-tailed link box comprises a housing within which one end of each of at least two cable tails (5) is terminated. The cable tails (5) connect to terminals connected to spigots (10) so as to form spigot assemblies (25). Removable links (2) can be fitted across pairs of spigots (10) so as to create connections between the cable tails (5). The link box is formed as a unitary chamber.
Patent NZ-524932-A (NZ)
Title: A thiazolidinedione derivative and its use as antidiabetic
Inventor: MILLAN MICHAEL
IPC: A61K31/4439
Filed: 2001-09-28
Abstract: Describes a compound 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione potassium salt or a pharmaceutically acceptable solvate thereof, and the use of that compound in the manufacture of a medicament for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
Patent NZ-524999-A (NZ)
Title: Adaptable directional floodlight
IPC: F21Y101/00
Filed: 2003-03-27
Abstract: An adaptable floodlight 10 capable of accommodating lamps of different sizes has i) a main housing with a forward opening, ii) a plurality of center housings 77b each having an attachment portion 79b being similarly sized on one end for interchangeable attachment to the opening of the main housing and having a different sized ring terminus 81b at it's opposite end, and iii) a plurality of differently sized lens housings 99a sized to be received on one of the ring terminuses. (62) Divided out of 504837
Patent NZ-525704-A (NZ)
Title: Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays
Inventor: UPMEIER BARBARA
IPC: G01N33/569
Filed: 2001-11-27
Abstract: The application discloses the use of intramolecularly, covalently cross-linked DNA polymerase or RNA polymerase proteins as immunological binding partners in immunological test procedures. The protein used may be HIV reverse transcriptase. A method for producing intramolecularly cross-linked HIV reverse transcriptase is also disclosed.
Patent NZ-528134-A (NZ)
Title: Phenylalanine enamide derivatives possessing a cyclobutene group, for use as integrin inhibitors
Inventor: BAILEY STUART
IPC: A61K31/44
Filed: 2002-01-18
Abstract: Phenylalanine enamide derivatives of formula (I) are described: wherein R1 is a group Ar1L2Ar2Alk- in which: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted arylene or heteroarylene group; and Alk is a chain -CH2-CH(R)-,  -CH=C(R)- or -CH(CH2R)- X is an -N(R2) group; V is an oxygen (O) or sulphur (S) atom; RX and RY are joined together to form an optionally substituted spiro linked cycloaliphatic or heterocycloaliphatic group; and RZ represents a halogen atom, or, -L1(Alk1)n(R3)v in which L is a covalent bond or a linker atom or group, Alk1 is an optionally substituted aliphatic or heteroaliphatic chain, R3 is a hydrogen or halogen atom or group selected from -OR3a [where R3a is a hydrogen atom or an optionally substituted alkyl or cycloalkyl], SR3a, -CN or an optionally substituted cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaIiphatic, aromatic or heteroaromatic group, n is zero or the integer 1 and v is the integer 1, 2 or 3 provided that when n is zero and L is a covalent bond v is the integer 1; and the salts, solvates, hydrates and N-oxides thereof. Furthermore compounds of formula (I) are able to inhibit the binding of integrins to their ligands and described is the use of compounds of formula (I) for the manufacture of a medicament for the treatment and/or prevention of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.