baber/WOPTO huggingface dataset:
Patent PT-1286942-E (PT)
Title: Method and catalyst for the selective production of acetic acid by catalytic oxidation of ethane and/or ethylene
Inventor: DINGERDISSEN UWE
IPC: B01J23/652
Filed: 2001-05-03
Abstract: A method for the selective production of acetic acid from a gas-phase feed of ethane, ethylene, or mixtures thereof and oxygen at elevated temperatures. The gas-phase feed is brought into contact with a catalyst, containing the elements Mo, Pd, X and Y in the gram atom ratios a:b:c: in combination with oxygen according to formula (I): MO<SUB>a</SUB>Pd<SUB>b</SUB>X<SUB>c</SUB>Y<SUB>d</SUB>. The symbols X and Y have the following meanings: X=one or several elements chosen from the group Cr, Mn, Nb, Ta, Ti, V, Te and W; Y=one or several elements chosen from the group B, Al, Ga, In, Pt, Zn, Cd, Bi, Ce, Co, Rh, Ir, Cu, Ag, Au, Fe, Fu, Os, K, Rb, Cs, Mg, Ca, Sr, Ba, Nb, Zr, Hf, Ni, P, Pb, Sb, Si, Sn, Ti and U: the indices a, b, c, d and x=the gram atom ration for the corresponding elements, where: a=1; b-0.0001 to 0.01; c=0.4 to 1; and d=0.005 to 1, wherein the space-time yield for the above oxidation to yield acetic acid is 470 kg/(hm<SUP>3</SUP>) and the selectivity of the oxidative reaction of ethane and/or ethylene to give acetic acid is, in particular, >=70 mol %. X=preferably Nb and an ammonium salt of niobium is used as niobium source.
Patent PT-1647950-E (PT)
Title: Data entry terminal with manual validation
Inventor: JO UTEN
IPC: H05K5/03
Filed: 2004-10-18
Abstract: Data entry terminal (1) with manual validation, comprising an upper face (6) consisting of a first portion (6a) and a second portion (6b), and a cover (9) being pivotally mounted around a pivot axis between a first position and a second position. The first position is a position for protecting means of validation (8) and the second position is a closed position. The cover (9) comprises a front wall (12) having a first (13) edge being substantially at the same level as the upper face (6) of the terminal (1). When said cover (9) is in first position, the first edge (13) of the front wall (12) of the cover (9) is provided to be positioned above, in particular, upon said second portion (6b), of the terminal (1), in order to form a shield around said first portion (6a).
Patent PT-1630709-E (PT)
Title: Mathematical analysis for the estimation of changes in the level of gene expression
Inventor: THEILHABER JOACHIM
IPC: G16B25/10
Filed: 2000-05-25
Abstract: The present invention relates to a highly accurate and reproducible mathematically-based methodology for quantifying the levels of differential gene expression from microassay protocols. Specifically, the present invention provides a simple deductive approach, grounded in a Bayesian framework, to circumvent the heuristic-based limitation of previous methodologies. Rather than seeking a point-estimate of the fold-change of the level of gene expression, the present invention utilizes the derivation of mathematical formula to determine the  a posteriori  distribution of  all  the fold-changes of differential gene expression which may be inferred from the given measurements. From this a  posteriori  distribution the following information may be obtained: (i) an estimator for the fold-change of the level of gene expression; (ii) confidence limits for the fold-change, at any given confidence level; and (iii) a P-value for assessing the statistical significance of change. The present invention also possesses the advantage that fold-change estimates and confidence limits may even be assigned to signal pairs where both signals are zero or negative, without resorting to heuristic thresholds.
Patent PT-1751093-E (PT)
Title: Substituted cyclohexylacetic acid derivatives
Inventor: SUNDERMANN BERND
IPC: C07C237/20
Filed: 2005-05-06
Abstract: Novel cyclohexylacetic acid compounds corresponding to formula I: processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including these compounds and related methods of treating or inhibiting certain diseases or conditions.
Patent PT-1766248-E (PT)
Title: Screw
Inventor: PALM ERICH
IPC: F16B39/22
Filed: 2005-07-09
Abstract: A screw is provided having an at least partially threaded ( 4 ) shank ( 7 ) and a screw head ( 3 ). An unthreaded section ( 2 ) is provided between the screw head ( 3 ) and the thread ( 4 ). The thread ( 4 ), at least in the distal area of the shank ( 7 ) facing the screw head ( 3 ) is provided with a groove ( 5 ), notch, slot, or the like crossing the thread ( 4 ).
Patent PT-1773478-E (PT)
Title: Tapered aperture multi-tee mixer and method
Inventor: GEHRKE JOERG-PETER
IPC: B01F5/04
Filed: 2005-07-07
Abstract: An apparatus and a method for mixing at least two fluid substances and carrying out or initiating a reaction between them, wherein the apparatus is a static mixer are described. The static mixer includes a fluid receiving chamber, a first conduit passing through the fluid receiving chamber and having at least one tapered aperture therethrough, and a second conduit operatively connected to the fluid receiving chamber.
Patent PT-2022788-E (PT)
Title: Novel crystal of 3-[5-[4-(cyclopentyloxy)-2- hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid
Inventor: YONEZAWA KENJI
IPC: A61K31/42
Filed: 2007-05-25
Abstract: The crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.0, 16.0, 23.3, 23.7 and 26.3°and the crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.6, 23.1, 24.7, 25.6 and 26.0° on 2¸ of diffraction angle in a powder X-ray diffraction pattern have a small specific volume, are hard to be charged with electricity, are easily handled and are useful for an active pharmaceutical ingredient of excellent anti-rheumatic agents.
Patent PT-1990134-E (PT)
Title: Processing device with a grinder
Inventor: HEESEMANN JUERGEN
IPC: B24B21/18
Filed: 2008-05-09
Abstract: The device has a spindle and a spindle head (22) adjustably arranged by an adjustment device. The spindle head is provided with a tool holder for connecting a replaceable tool with the spindle, and a grinding tool inserted into the tool holder. A placing device (27) is provided for the grinding tool and arranged outside an operating region (26) for a workpiece that is displaced into the tool. The tool is handled in the placing device with a mechanism for relaxation of a belt (16).
Patent PT-2505586-E (PT)
Title: Indole compound and pharmaceutical use thereof
Inventor: SHINICHI KIKUCHI
IPC: C07D405/14
Filed: 2010-11-25
Abstract: Provided is an agent for the treatment or prophylaxis of inflammatory diseases, allergic diseases, autoimmune diseases, transplant rejection or the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as described in the specification.
Patent PT-2523960-E (PT)
Title: Heterocyclic carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring
Inventor: HACHTEL STEPHANIE
IPC: C07D498/04
Filed: 2011-01-12
Abstract: Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonists The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
Patent PT-552329-E (PT)
Inventor: BUZZETTI FRANCO
IPC: C07D209/34
Filed: 1992-07-10
Abstract: The invention provides new methylen-indole derivatives of formula (I)   <CHEM>  wherein  R is a group <CHEM>  in which   R4   is hydrogen, hydroxy, C1-C6 alkoxy, C2-C6 alkanoyloxy, carboxy, nitro or NHR7, wherein R7 is hydrogen or C1-C6 alkyl; R5   is hydrogen, C1-C6 alkyl or halogen; and R6   is hydrogen or C1-C6 alkyl; n   is zero, 1 or 2; R1   is hydrogen, C1-C6 alkyl or C2-C6 alkanoyl; R2   is hydrogen, C1-C6 alkyl, halogen, cyano, carboxyl, nitro or -NHR7 in which R7 is as defined above; R3   is hydrogen, C1-C6 alkyl or C2-C6 alkanoyl; and the pharmaceutically acceptable salts thereof; and wherein, when,at the same time, R2 is hydrogen, C1-C6 alkyl, halogen or cyano and R3 is hydrogen, R1 and n being as defined above, then at least one of R4, R5 and R6 is other than hydrogen, which are useful as tyrosine kinase inhibitors.
Patent PT-642331-E (PT)
Inventor: MCLEOD KENNETH J
IPC: A61F2/28
Filed: 1993-05-26
Abstract: A method and apparatus for preventing osteopenia, promoting bone tissue growth, ingrowth, and healing of bone tissue includes the step of and means for applying a mechanical load to the bone tissue at a relatively low level on the order of between about 50 and about 500 microstrain, peak-to-peak, and at a relatively high frequency in the range from about 10 and about 100 Hz. Mechanical loading at such strain levels and such frequencies has been found to prevent bone loss and enhance new bone formation.
Patent PT-628311-E (PT)
Inventor: ISHII AKIO
IPC: A61K31/52
Filed: 1993-07-07
Abstract: An antidepressant containing an active ingredient comprising a xanthine derivative represented by general formule (I) or a pharmacologically acceptable salt thereof, wherein R<1>, R<2> and R<3> may be the same or different from one another and each represents hydrogen, lower alkyl, alkyl or propargyl; R<4> represents cycloalkyl, -(CH2)n-R<5> (wherein R<5> represents optionally substituted aryl or optionally substituted heterocyclic group, and n represents an integer of 0 to 4) of group (A) wherein Y<1> and Y<2> may be the same or different from each other and each represents hydrogen, fluorine or methyl, and Z represents optionally substituted aryl, group (B) (wherein R<6> represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro or amino, and m represents an integer of 1 to 3), or optionally substituted heterocyclic group; and X<1> and X<2> may be the same or different from each other and each represents O or S. <CHEM>
Patent PT-652766-E (PT)
Inventor: O'CONNOR BARBARA H
IPC: A61K38/27
Filed: 1993-07-29
Abstract: A stable pharmaceutically acceptable aqueous formulation containing human growth hormone, a buffer, a non-ionic surfactant, and, optionally, a neutral salt, mannitol, or, a preservative, is disclosed. Also disclosed are associated means and methods for preparing, storing, and using such formulations.
Patent PT-651946-E (PT)
Inventor: BAKKER LIEUWE
IPC: A23L3/3418
Filed: 1994-11-09
Abstract: The invention relates to a method for controlling the composition of a gas mixture present in a space (2,3) by detecting the concentration of at least one component of the gas mixture and extracting from the space and subjecting to a treatment at least a portion of the gas mixture, wherein the concentration of the at least one component is detected in the portion of the gas mixture extracted from the space. The invention also relates to an apparatus for performing this method provided with means connected to the space over a supply duct (12,13) and a discharge duct (5,6) gas mixture extracted from the space, control means connected for signal generating to the gas mixture treatment means, and means connected to the supply duct for detecting the concentration of at least one component of the gas mixture, which concentration detecting means are connected for signal generating to the control means (18). The described method and apparatus enable performing of concentration measurements at a central location without the necessity of having to install separate sample ducts. <IMAGE>
Patent PT-632838-E (PT)
Inventor: MAUBOIS JEAN-LOUIS
IPC: C12Q1/04
Filed: 1994-01-24
Abstract: PCT No. PCT/FR94/00082 Sec. 371 Date Sep. 22, 1994 Sec. 102(e) Date Sep. 22, 1994 PCT Filed Jan. 24, 1994 PCT Pub. No. WO94/17201 PCT Pub. Date Aug. 4, 1994A medium is prepared for counting propionic bacteria under anaerobic conditions. The medium contains a complex culture medium composed in particular of a casein hydrolysate and a yeast extract, supplemented with at least one lithium compound, such as lithium lactate, and at least one polyol and/or one or more antibiotics. The counting of the bacteria in a biological sample is carried out by incubation of a sample or decimal dilutions of it in a counting medium.
Patent PT-662833-E (PT)
Inventor: KIMURA YUZO
IPC: A61K31/4704
Filed: 1994-07-25
Abstract: PCT No. PCT/JP94/01222 Sec. 371 Date Mar. 28, 1995 Sec. 102(e) Date Mar. 28, 1995 PCT Filed Jul. 25, 1994 PCT Pub. No. WO95/03802 PCT Pub. Date Feb. 9, 1995This invention provides an aqueous composition wherein a hardly water-soluble active compound, 6-[3-(3,4-dimethoxybenzyl)amino-2-hydroxypropoxy]carbostyril or a salt thereof is dissolved in water in an effective amount, particularly in an amount sufficient for exhibiting the pharmacological activities, by using as a solubilizer DL-lactic acid.
Patent PT-794824-E (PT)
Title: Method and device for separating fibrin monomer from blood plasma
Inventor: HOLM NIELS ERIK
IPC: B01D21/01
Filed: 1995-12-01
Abstract: A method and a device for separating a component, such as fibrin monomer from blood, by centrifugation, involve feeding of blood admixed an anticoagulant to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall. The top wall or the bottom wall is formed by a piston body displaceable within the first chamber. This method involves furthermore a centrifugation of the device about the said common axis to substantially separate blood into a cell fraction and a plasma fraction followed by the resulting plasma fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall. The outer cylindrical wall extends coaxially with the said common axis, whereby a fraction with fibrin I is caused to be separated in the second chamber while a suitable enzyme is being added. The separation of fibrin monomer from the plasma fraction in the second chamber is carried out during continued centrifugation whereby a fibrin polymer is deposited on the cylindrical outer wall of said second chamber, whereafter the fluid fraction collected at the bottom of the second chamber is transferred while influenced by the piston body to the first chamber. The fraction with fibrin polymer remaining in the second chamber is substantially deposited on the cylindrical wall and is caused to be dissolved by addition of a solvent and by centrifugation, whereafter it is transferred to a receiving container by passing after addition of a binder to the enzyme through a filter removing said enzyme, whereby a fibrin monomer containing solution is provided.
Patent PT-1006950-E (PT)
Inventor: OSTHER KURT B
IPC: A61F2/00
Filed: 1997-08-29
Abstract: Method for the effective transplantation of chondrocytes/cartilage to an articular joint surface defect is taught, as well as a description of certain instruments and kit for practicing the invention. <IMAGE>
Patent PT-1037525-E (PT)
Inventor: HILPERT JEAN-JACQUES
IPC: A01K11/00
Filed: 1998-12-03
Abstract: An animal ear tag including a female opening through which a head of a stem of a coupling member can pass to effect a coupling action when installing the tag on an animal, the female opening being formed as part of a separate enclosed boss component of hard material, the boss component having a flange extending peripherally from an external surface thereof, the flange being located within resilient material forming a part of the ear tag sized to anchor the boss component to the tag.
Patent PT-935961-E (PT)
Title: (r)-2-(3-benzoylphenyl)propionic acid salts and pharmaceutical preparations containing them
Inventor: MELILLO GABRIELLA
IPC: A61K31/19
Filed: 1999-01-25
Abstract: A new use of the enantiomer (R)-ketoprofen and of its salts with suitable organic and inorganic bases in the therapy of neutrophil-dependent diseases and phlogistic processes is described as well as pharmaceutical preparations containing such compounds and useful for oral, parenteral or topical administration.
Patent PT-1125285-E (PT)
Inventor: SALAMI REDWAN
IPC: H04Q7/22
Filed: 1999-10-27
Abstract: A pitch search method and device for digitally encoding a wideband signal, in particular but not exclusively a speech signal, in view of transmitting, or storing, and synthesizing this wideband sound signal. The new method and device which achieve efficient modeling of the harmonic structure of the speech spectrum uses several forms of low pass filters applied to a pitch codevector, the one yielding higher prediction gain (i.e. the lowest pitch prediction error) is selected and the associated pitch codebook parameters are forwarded.
Patent SG-131694-G (SG)
Title: Novel vitamin D analogues
Inventor: CALVERLEY MARTIN JOHN
IPC: C07C401/00
Filed: 1994-09-12
Abstract: The present invention relates to compounds of formula (I), in which formula R stands for an alkyl group containing from 7 to 12 carbon atoms optionally substituted with a hydroxy group; and derivatives of the compounds of formula (I) in which one or more hydroxy groups have been transformed into -O-acyl or -O-glycosyl or phosphate ester groups, such masked groups being hydrolyzable in vivo, in pure form or in mixtures. The present compounds find use in both the human and veterinary practice in the treatment and prophylaxis of autoimmune diseases, including diabetes mellitus, hypertension, inflammatory diseases such as rheumatoid arthritis and asthma as well as diseases characterized by abnormal cell differentiation and/or cell proliferation, and/or imbalance in the immune system.
Patent IE-42427-L (IE)
Title: STEROIDAL [16Ó,17Ó-b] 1,4-DIOXANES
IPC: A61K31/57
Filed: 1975-01-15
Abstract: 1498132 Steroid [16α,17-b]dioxanes E R SQUIBB & SONS Inc 15 Jan 1975 [16 Jan 1974] 1776/75 Headings C2U and C2C The invention comprises 3,20-dioxo pregnenes having an 11#-hydroxy or 11-oxo group and having at position 16,17 a fused-on 1,4-dioxane or dihydro - 1,4 - dioxin ring. Preferred are the #<SP>4</SP>, #<SP>1,4</SP>, #<SP>4,6</SP> and #<SP>1,4,6</SP> compounds of formula wherein A 1 is selected from (the valence on the left being attached to the 17-oxygen atom); R 1 is H, C 1-8 alkyl, or aryl; R 2 is H, C 1-8 alkyl or aryl-(C 1-8 alkyl); R 3 is C 1-8 alkyl, C 3-6 cycloalkyl, or aryl; R 4 and R 5 are each C 1-8 alkyl, or aryl; P is H, Me or Cl; Q is H, Me or F; X is H or halo; Y is H, Y<SP>1</SP> is OH or Y + Y<SP>1</SP> = oxo; Z is H, halo, OH or acyloxy; the term "aryl" signifying phenyl optionally sub stituted with one or more halo, C 1-8 alky or C 1-8 alkoxy groups. The inventive compounds are prepared from analogous 16α,17α-diol cyclic borates by synthesizing the 16,17-dioxane ring as shown in the reaction scheme infra, and subsequently optionally introducing #<SP>6</SP> unsaturation (e.g. with DDQ) acylating at position 21 (this may also be effected on the intermediates marked * and **), hydrolysing a 21-ester group, or converting 21- OH to 21-halo via a 21-sulphonate (this may also be effected on the intermediate marked **) (R 1 , R 3 , R 4 , R 5 and Z are as above; R 6 is alkyl or aryl; R 7 is alkyl or aralkyl; each X is alkyl or the two X's together are ethylene). Reagents: (a) CH 2 :C(R 1 )N 2 ; (b) (XO) 2 C(R 4 )C(R 5 )N 2 ; (d) THP.O.CH 2 CHN 2 ; (e) m-chloroperhenzoic acid; (f) e.g. periodic acid; (g) e.g. f-toluenesulphonic acid; (h) NaBH 4 ; (i) MeSO 2 Y (Y= halo); (j) NaHCO 3 /DMSO; (k) e.g. HCl; (1) (R 3 CO) 2 O; (m) Fetizon's reagent; (n) e.g. acetic acid; (p) tautomerism. A 16,17-cycloborate is prepared from 21-chloro- 9 - fluoro - 11#,16α,17 - trihydroxypregna - 1,4- diene - 3,20 - dione by reaction with boric oxide in methanol. Potassium phthalimide + α - (bromomethyl) styrene # N - (2 - phenyl - 2 - propenyl)phthalimide # ethyl N - (2 - phenyl - 2 - propenyl) carbamate # ethyl N - nitroso - N - (2 - phenyl - 2- propenyl)carbamate # 2 - phenyl - 3 - diazo - 1- propene (Example 4). 2 - (Tetrahydropyran - 2 - yloxy)acetonitrile # 2 - (tetrahydropyran - 2 - yloxy)ethylamine # N - [2 - (tetrahydropyran - 2 - yloxy)ethyl]urea # N - nitroso - N - [2 - (tetrahydropyran - 2 - yloxy) ethyl]urea # 2 - (tetrahydropyran - 2 - yloxy) - 1- diazoethane (Example 18). Potassium phthalimide + α-bromopropiophenone # N - (1 - methyl - 2 - oxo - 2 - phenylethyl) phthalimide # 2 - (1 - phthalimidoethyl) - 2- phenyl - 1,3 - dioxolane # 2 - (1 - aminoethyl) - 2- phenyl - 1,3 - dioxolane # 2 - phenyl - 2 - [1- (ethoxycarbonylamino)ethyl] - 1,3 - dioxolane # 2 - phenyl - 2 - (1 - diazoethyl) - 1,3 - dioxolane (Example 40). Antiinflammatory compositions for oral and topical administration comprise a compound of Formula I and a carrier.
[GB1498132A]
Patent IE-810212-L (IE)
Title: Locking mechanism
IPC: E05B65/00
Filed: 1981-02-03
Abstract: The door (3) of a security enclosure has a primary lock (4) for locking the boltwork (1,2). A drill-resistant disc (11) is rotatably mounted between the lock and the exterior of the door, and the wire (12) of a relocker (14) passes over the circumference of the disc. If a drilling attack is made on the lock the disc (11) will be encountered and will be rotated by the drill tip to frustrate penetration of the disc by the drill. Furthermore, if the drill is aimed at the circumferential portion of the disc which guides the wire (12) any success in penetrating the disc will sever or dislodge the wire to allow the relocker (14) to move under the action of a spring (18) into a position in which it provides an additional locking action in the boltwork. 
[EP0034019A1]
Patent IE-870497-L (IE)
Title: Tetrahydropyridin-3-carboxaldehyde oxime
IPC: A61K31/445
Filed: 1987-02-26
Abstract: Compounds useful in the treatment of Alzheimer's disease, senile dementia, or memory disorders which have the formula   <IMAGE>   in which R represents a hydrogen atom, a linear, branched or cyclic alkyl radical, saturated or unsaturated, containing up to 8 carbon atoms, possibly substituted by a free or esterified carboxy radical or R represents an aralkyl radical containing up to 10 carbon atoms and R' represents a linear or branched, saturated or unsaturated, alkyl radical, containing up to 8 carbon atoms, a radical -COalk1 or a radical -(CH2)2N(alk2)2, alk1 and alk2 representing an alkyl radical containing up to 8 carbon atoms, as well as their addition salts with acids. Also compositions containing the same, method of preparation and method of treatment using the same.
Patent FI-822554-L (FI)
Inventor: TESCH GYNTER HORST
IPC: E01C9/08
Filed: 1982-07-20
Abstract: A mat like composite body (1) comprising a cover layer (2) of a fiber or filament fleece and a backing layer (3) comprising the same fleece or of a synthetic plastic sheet (7), in particular one provided with depressions (8), between the cover layer (2) and the backing layer (3) a layer (5) of particles (6) of an inert material, preferably rock particles, is arranged. The three layers (2, 3 5) are needle-bonded together prefereably with holding fibers (4) taken from the cover layer (2) is described. Different possible applications of the composite body (1) are disclosed, whereby the composite body (1) by the utilization of the properties of the granular particles (6), which serve for example to dilute and/or carry other particles (13), such as binders, active ingredients, etc, is applied to the external treatment of human or animal bodies, sound attenuation, fire protection, the weighting of third bodies or as a so-called car protection mat. Furthermore, advantageous measures are disclosed for the needle-bonding of for example rock particles.