baber/WOPTO huggingface dataset:
Patent CA-2813300-A1 (CA)
Title: Recombinant polypeptides for membrane fusion and uses thereof
Inventor: DUNCAN ROY
IPC: C12N15/02
Filed: 2011-09-29
Abstract: Disclosed is a recombinant polypeptide for facilitating membrane fusion. The recombinant polypeptide having a sequence with at least 80% sequence identity with the ectodomain of p14 fusion-associated small transmembrane (FAST) protein and having a functional myristoylation motif, a transmembrane domain from a FAST protein and a sequence with at least 80% sequence identity with the endodomain of p15 FAST protein. A targeting ligand can be added to the recombinant polypeptide for selective fusion. The recombinant polypeptide can be included in the membrane of a liposome, or the like, to facilitate the delivery of bioactive compounds, such as siRNA, or the recombinant polypeptide can be mixed with a lipid carrier and added to cultured cells to induce cell-cell fusion and heterokaryon formation.
Patent CA-2816095-A1 (CA)
Title: Position sensing using electric dipole fields
Inventor: BAR-TAL MEIR
IPC: A61B5/042
Filed: 2013-05-22
Abstract: A medical apparatus, including a reference probe having a flexible insertion tube with a distal end for insertion into a body cavity, a pair of isolated electrodes fixedly attached to the distal end, and a position sensor fixedly located in the distal end. The apparatus also includes a supplementary probe having an electrode fixed thereto. The apparatus further includes a processor, configured to inject respective alternating currents into the pair of isolated electrodes so as to generate an electrical field therefrom, to measure a potential generated at the electrode of the supplementary probe in response to the electrical field, and to evaluate a location of the supplementary probe with respect to the reference probe in response to the measured potential and in response to a position of the distal end indicated by the position sensor.
Patent CA-2817034-A1 (CA)
Inventor: HOERENTRUP JOBST
IPC: H04N21/482
Filed: 2004-12-13
Abstract: A method for generating an on-screen menu comprising menu buttons (BG81,...,BG86') and other menu items, e.g. help text, is characterized in that one or more groups of menu buttons or menu items are defined, wherein a group comprises one or more menu buttons or menu items and has associated a defined area on the screen. A state is assigned to a button, the state being "enabled" or "disabled", wherein only an enabled button or item may be displayed, and wherein within a group not more than one button or item may be enabled. The state of a button can be changed by commands associated with other buttons.
Patent CA-2817191-A1 (CA)
Inventor: SAETROM PAL
IPC: C12N15/113
Filed: 2011-10-10
Abstract: The present invention provides a short RNA capable of upregulating MafA expression in a human cell, wherein said short RNA includes a first strand which is 9 to 25 nucleotides in length and comprises the sequence AUCUGUACUGGAUGAGCGG or UUUCCCGCAGGAGAUUGAC. Also provided are uses thereof, particular medical uses, and induced cells and uses thereof.
Patent CA-2817198-A1 (CA)
Title: Compositions and methods for treating hyperproliferative disorders
Inventor: MAURER BARRY JAMES
IPC: A61P35/00
Filed: 2010-11-12
Abstract: A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a ceramide-increasing retinoid such as fenretinide or a pharmaceutically acceptable salt thereof; and (b) at least one (and in certain embodiments at least two) compounds selected from the groups consisting of (i) a non-18 carbon chain length L-threo-sphinganine(s) or pharmaceuticeutically acceptable salt thereof, (ii) glucosylceramide or glucosyhdihydro)ceramide synthesis inhibitor(s), and (iii) sphingomyelin or dihydrosphingomyelin synthase inhibitor(s).  Preferred L-threo-sphinganines are of carbon chain length 17 carbons, 19 carbons and 20 carbons. A preferred glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol.  A preferred sphingomyelin or dihydrosphingomyelin synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred hyperproliferative disorder is brain cancers.
Patent CA-2818701-A1 (CA)
Inventor: FARIA-WAZIEY PAULA A
IPC: A61K35/766
Filed: 2011-11-22
Abstract: Simvastatin is used to modulate VSV infection at the level of viral replication. Both lipid-lowering and pleiotropic cellular effects of simvastatin are exploited in the modulation. Simvastatin upregulates the expression of Rael and Nup98, therefore altering normal cellular mRNA distribution and reverting VSV's mRNA export block. Furthermore, simvastatin causes redistribution of Flotillin-1, which affects VSV replication/budding. Simvastatin is further used as a neoadjuvant for the selective modulatory control of live VSV oncolytic therapy.
Patent CA-2820969-A1 (CA)
Inventor: MOY YEI F
IPC: F04B43/08
Filed: 2011-12-22
Abstract: A medical pump includes a chassis having a fixed seat and a carriage having a footing for receiving a fluid delivery device and restricting its movement. An actuator assembly is provided that allows for moving the carriage between an opened and closed position to engage the fluid delivery device to the seat. A rack and pinion system is utilized in combination with a cam element and spring element to provide a bi-stable actuator assembly that urges the carriage into a fully opened position or a fully closed position and will not allow the carriage to dwell in an intermediate position if external force is withdrawn.
Patent CA-2821556-A1 (CA)
Inventor: JOLICOEUR PAUL
IPC: E04G7/20
Filed: 2005-03-28
Abstract: The invention includes a work platform and support system that includes a hub and joist configuration, wherein the hubs and joists are capable of articulation, or pivoting. One method of installation allows for sections of new work platform system to be extended from an existing suspended work platform system. The system is also capable of supporting, without failure, its own weight and at least four times the maximum intended load applied to it.
Patent CA-2821665-A1 (CA)
Inventor: BROWN MICHAEL D
IPC: F16K37/00
Filed: 2011-12-02
Abstract: A flow control regulator assembly (100) having a regulator body (101 ) with an inflow channel (141 ) that couples an inlet of the regulator body (101 ) to a flow rate port and an exit flow channel (149) which couples the flow rate port to an outlet port (113) of the regulator body (101 ). The minimal cross-sectional area of the exit flow channel (149) is larger than the maximum cross-sectional area of the inflow channel (141 ).
Patent CA-2822455-A1 (CA)
Inventor: SALEHI EBRAHIM
IPC: C10G1/04
Filed: 2013-08-01
Abstract: Systems and processes for producing hydrocarbon products integrate an XTL process for producing hydrocarbons with open pit oil sands mining process. The integration includes one or more of steam integration, process water integration, water treatment system integration, nitrogen integration, and integrated use of carbon-containing products or by-products from one process in another process. An example of an integrated process comprises: (a) converting a carbon-containing feed stream to a first hydrocarbon product stream by an XTL process, wherein waste water is produced by said XTL process; (b) diverting at least a portion of the waste water produced by said XTL process to an open pit oil sands mining process; (c) mixing the waste water with oil sands ore produced by said open pit oil sands mining process to form a slurry; (c) recovering said oil product from the slurry; and (d) converting said oil product to a second hydrocarbon product stream.
Patent CA-2824437-A1 (CA)
Inventor: ALI AMJAD
IPC: A61K31/04
Filed: 2012-01-12
Abstract: A compound having the structure (I) useful for treating hypertension, pulmonary arterial hypertension, congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
Patent CA-2825739-A1 (CA)
Title: Controleur et procede de generation sequencee de vagues dans une enceinte
Inventor: MCFARLAND BRUCE
IPC: F04D35/00
Filed: 2013-08-23
Abstract: Une commande dapplication mobile dappareil de génération de vague et une méthode sont décrites. La commande mobile actionne plusieurs chambres de génération de vagues en séquence au moyen dun retard entre lactionnement de chaque chambre pour produire une vague de surf dans une piscine. La commande dapplication mobile permet à lutilisateur de sélectionner le type exact de vague à produire par lappareil en sélectionnant la taille, la forme et le modèle de vague. Lapplication permet également à lutilisateur dutiliser une caméra pour photographier ou enregistrer une personne surfant sur la vague, y compris lutilisateur lui-même.
Patent CA-2827791-A1 (CA)
Inventor: PEARCE CODY A
IPC: E21B10/46
Filed: 2011-10-27
Abstract: In one example, a method for producing a cutting device matrix includes mixing a plurality of constituent matrix materials using a resonant acoustic mixing process until the constituent matrix materials are substantially homogeneously distributed throughout the matrix.
Patent CA-2828124-A1 (CA)
Inventor: CURRY JON K
IPC: A01B1/02
Filed: 2013-09-24
Abstract: The asymmetrical head of a shovel incorporates a vertically oriented edge extending upwardly from the tip of the head to a recessed leading edge. The construction of the head permits it to function both as a pivot and as a lever, as well as facilitating the initial penetration of the head in soil.
Patent CA-2830147-A1 (CA)
Title: Method for dyeing aramid fibers and dyed aramid fibers
Inventor: OIWA NORIHIRO
IPC: D06P1/30
Filed: 2012-03-29
Abstract: [Problem] To provide a method for dyeing aramid fibers which is applicable to any of para-aramid fibers, para-coaramid fibers, and meta-aramid fibers and by which aramid fibers are dyed in practical concentrations required for new applications of aramid fibers. The dyed aramid fibers have suffered neither considerable dyeing unevenness nor a considerable dimensional change nor a considerable decrease in material property. The dyed fibers further have satisfactory color fastness, in particular, light fastness. Also provided are dyed aramid fibers. [Solution] A dyeing method which comprises one or more dyeing operations each comprising a combination of the following steps: a dye application step in which a vat dye or a sulfur dye is applied to aramid fibers; a solvent treatment step in which the aramid fibers are treated with a treating liquid comprising a polar solvent; and a heat treatment step in which after the solvent treatment step, the aramid fibers are heat-treated according to need.
Patent CA-2830595-A1 (CA)
Title: Phrase-based communication system
Inventor: PONIATOWSKI ROBERT F
IPC: H04N5/445
Filed: 2011-04-18
Abstract: A client device, such as a digital video recorder, provides a phrase-based communication system in which users are presented with a dynamic messaging interface of selectable phrases and other elements. At least some of the phrases are selected using algorithms that identify phrases that are likely to be useful to the particular user and/or the context in which the user is creating a message. In this manner, a user is able to generate useful messages quickly, without being limited to stale and fixed canned messages. Popular phrases are identified by, for example, a server, based on messages exchanged between users. These popular phrases are harvested for use in the dynamic messaging interface. Moreover, context-sensitive metadata elements are added to the dynamic messaging interface based on, for example, content that the user is currently viewing or about which the user is currently accessing information.
Patent CA-2840344-A1 (CA)
Inventor: CHAUFFE STEPHEN J
IPC: F16K3/30
Filed: 2012-02-29
Abstract: An apparatus includes a counter for tracking and communicating a number of plug drops through a longitudinal bore; a plug element adapted to be dropped into the longitudinal bore; and a valve defining a plug seat to be disposed within the longitudinal bore to catch, the plug element when the plug element is dropped and when the number of plug drops as communicated by the counter exceeds a predetermined number. A method, includes: dropping a plurality of plugs down a longitudinal bore in which a plurality of plug seats are disposed; counting the number of plug drops from within the longitudinal bore; and catching one of the plugs at a preselected one of the plug seats when the number of plug drops exceeds a predetermined number.
Patent CA-2840711-A1 (CA)
Inventor: MALONEY KEVIN
IPC: A61K47/02
Filed: 2012-06-29
Abstract: Aspects of the invention are directed to arginine-free polypeptide-containing compositions and methods for treating disorders associated with inflammation or the autoimmune response. In particular, the polypeptide is etanercept.
Patent CA-2844834-A1 (CA)
Inventor: GRETHER UWE
IPC: C07D417/12
Filed: 2012-09-10
Abstract: The present invention relates to compounds of the formula I wherein R1 to R4 are defined in the description, and to pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as particularly dyslipidemia, atherosclerosis and cardiovascular diseases.
Patent CA-2850899-A1 (CA)
Inventor: BOTHMANN RICH D
IPC: B25B19/00
Filed: 2014-05-02
Abstract: Description dune enclume pourvue dailes ayant une surface supplémentaire comparativement aux enclumes de clé à chocs de la technique antérieure. Les ailes viennent en contact avec des marteaux respectifs dans un sens radial et se chevauchent les unes les autres dans un sens axial en travers de linterface entre les deux marteaux. Chacun de ces derniers peut comprendre un évidement de manière quune aile ne puisse pas venir en contact avec le marteau associé à lautre aile. Dans un mode de réalisation, la surface de laile peut être inclinée pour augmenter la quantité de matière sétendant au-dessus de linterface des marteaux.
Patent CA-2854750-A1 (CA)
Inventor: DODGE ARTHUR B III
IPC: B60P7/06
Filed: 2014-06-20
Abstract: La présente invention concerne un tapis de sécurité pour atténuer la migration de charges dans un navire de marchandises. Le tapis de sécurité comprend une longueur, une largeur et une hauteur, et comprend une première sous-section et une deuxième sous-section, une zone de la deuxième sous-section étant plus petite quune zone de la première sous-section. Le tapis de sécurité comprend une première ligne de pli le long de la longueur ou de la largeur de la feuille et à proximité dun bord de la feuille définissant une limite entre la première et la deuxième sous-section, la première sous-section présentant une première inclinaison en pliant, le long de la première ligne de pli, la deuxième sous-section sous la première.
Patent CA-2858834-A1 (CA)
Title: Surface modification for catheters comprised of multiple materials
Inventor: LI JUN
IPC: A61L29/04
Filed: 2012-12-14
Abstract: Catheters and a method for preparation thereof, the catheter comprising as component parts thereof a catheter body, a juncture hub, at least one extension line and at least one connector, each of said component parts comprising an exterior surface, at least one lumen having an intraluminal surface and a bulk polymer, wherein the intraluminal or external surface of a first of said component parts and the exterior or intraluminal surface of a second of said component parts comprise a hydrophilic polymer layer thereon having an Average Dry Thickness of at least about 50 nanometers and the first and second component parts comprise bulk polymers having different chemical compositions.
Patent CA-2858861-A1 (CA)
Title: A method for monitoring the operation of a liquid food processing system
Inventor: SVENSSON CECILIA
IPC: H05H9/00
Filed: 2012-12-14
Abstract: A method for monitoring the operation of a liquid food processing system is provided. The method comprises the steps of initiating a fluid flow through at least one section of said food processing system; and determining a pressure difference across said at least one section during said fluid flow for monitoring removal or build-up of deposits, said removal or build-up being caused by said fluid flow.
Patent CA-2863454-A1 (CA)
Inventor: DE WOLF CORNELIA ADRIANA
IPC: C09K8/74
Filed: 2013-02-11
Abstract: The present invention relates to the use of solutions containing glutamic acid N,N-diacetic acid or a salt thereof (GLDA) and/or methylglycine N,N-diacetic acid or a salt thereof (MGDA) in treating subterranean formations, wherein the solutions contact carbon steel-containing equipment, and to a system containing a carbon steel-containing material in contact with a solution containing glutamic acid N,N-diacetic acid or a salt thereof (GLDA) and/or methylglycine N,N-diacetic acid or a salt thereof (MGDA), at elevated temperatures and/or employing carbon steel types as usually found in subterranean formations.
Patent CA-2866057-A1 (CA)
Title: Door sealing assembly for a railcar and method of assembling the same
Inventor: DALSKI ROGER A
IPC: B61D7/22
Filed: 2014-10-06
Abstract: A railcar door sealing assembly includes a first door seal member coupled to a first door plate of a first door of the railcar. The door sealing assembly also includes a second door seal member coupled to a second door plate of a second door of the railcar.  The first door seal member at least partially overlaps with the second door seal member in a face-to-face relationship when the first door and the second door are in the closed position.
Patent CA-2867838-A1 (CA)
Title: Medical surgical waste collection and disposal system including a rover and a docker, the docker having features facilitating the alignment of the docker with the rover
Inventor: LALOMIA BRENT S
IPC: A61M1/00
Filed: 2006-12-13
Abstract: A waste collection and disposal system (100) for use in health care facilities is provided. The system (100) includes a mobile waste collection unit (102) for moving between use areas in the health care facility to collect waste material generated during medical procedures including body fluids, body tissues, saline, etc. The waste collection unit (102) includes stacked upper (200) and lower (202) waste containers for receiving the waste material. During use, the upper waste container (200) can be emptied into the lower waste container (202) for temporary storage. In addition, independently controlled vacuum levels can be provided in the waste containers (200, 202) during complex procedures.  Once a user desires to empty the waste collection unit (102), the waste collection unit (102) is wheeled to a docking station (104). At the docking station (104), the waste material is off-loaded to a waste drain (D) and the waste collection unit (102) is cleaned and rinsed for further use.
Patent CA-2867900-A1 (CA)
Inventor: ARNIM NATHAN
IPC: A61M25/088
Filed: 2013-04-17
Abstract: A retrograde delivery catheter includes at its distal end an expandable member configured to at least partially occlude the coronary sinus of a patient's heart, and has a length and variable stiffness that allows the distal end to be selectively articulated so as to be positioned in the coronary sinus. The delivery catheter has a triple lumen construction with a primary lumen extending between the proximal and distal ends and configured to allow a cardioplegic fluid to be delivered to the coronary sinus. A second lumen provides for balloon inflation while a third lumen allows monitoring of a pressure within the coronary sinus. A torque may be applied and a reinforcement member within the delivery catheter provides improved torque transmission along the length of the catheter.
Patent CA-2869265-A1 (CA)
Inventor: TOKHTUEV EUGENE
IPC: G01N21/01
Filed: 2013-03-29
Abstract: A fluorescence analysis system may include a sensor head that has a light source configured to emit light into a flow of fluid, a detector configured to detect fluorescent emissions from the flow of fluid, and a temperature sensor. The system may also include a flow chamber that includes a housing defining a cavity into which the sensor head can be inserted. In some examples, the housing is configured such that, when a flow of fluid enters the housing, the flow of fluid divides into at least a major stream passing adjacent the light source and the detector and a minor stream passing adjacent the temperature sensor. Such a flow chamber may direct fluid past different sensors components while inhibiting a build-up of solids particles, the generation of air locks, or other flow issues attendant with continuous or semi-continuous online operation.
Patent CA-2875391-A1 (CA)
Title: Utilisation du cd147 comme recepteur pour l'adhesion impliquant les pili des meningocoques a l'endothelium vasculaire
Inventor: NASSIF XAVIER
IPC: A61K39/395
Filed: 2013-07-15
Abstract: Cette invention concerne l'utilisation d'un inhibiteur de l'interaction entre la protéine associée aux pili de type IV et le CD147 pour prévenir ou traiter une bactériémie et/ou une infection méningocoque. Cette invention concerne également l'utilisation de cet inhibiteur en association avec un composé antibactérien, par exemple un composé utilisé pour prévenir ou traiter l'infection à méningocoque. L'invention concerne également une méthode permettant de prévenir et/ou de traiter la bactériémie et/ou l'infection à méningocoque, et une méthode permettant de cribler les inhibiteurs de l'interaction entre le CD147 et la protéine associée aux pili de type IV.
Patent CA-2875850-A1 (CA)
Inventor: COOPER STEVE
IPC: H04L29/06
Filed: 2014-12-23
Abstract: Selon une réalisation donnée à titre dexemple, un procédé de synchronisation dune version automatique de composants dépendants sexécutant sur des systèmes hétérogènes, par suite de la réception dune communication au moyen dun protocole prédéterminé acheminé par un réseau chez un hôte, détermine si le code client requis est présent ou non sur le client. En fonction de la détermination que le code client requis nest pas présent sur le client, la plus récente version du composant client est demandé chez lhôte. Un ou plus dun modules chargeables sont situés chez lhôte, reliés à un composant de lhôte qui représente le composant client. Un objet comprenant le ou les modules chargeables est envoyé au client, dans lequel le client reçoit, charge et exécute lobjet en tant que nouveau composant pour communiquer avec le composant de lhôte au niveau le plus récent.
Patent CA-2876568-A1 (CA)
Inventor: LIU JUN
IPC: H01M10/05
Filed: 2013-01-08
Abstract: Energy storage devices having hybrid anodes can address at least the problems of active material consumption and anode passivation that can be characteristic of traditional batteries. The energy storage devices each have a cathode separated from the hybrid anode by a separator. The hybrid anode includes a carbon electrode connected to a metal electrode, thereby resulting in an equipotential between the carbon and metal electrodes.
Patent CA-2876573-A1 (CA)
Inventor: KOSHIBA TAKAHIRO
IPC: A61K31/41
Filed: 2013-06-14
Abstract: Compounds represented by the following formula (I); wherein each symbol is as defined in the specification, are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.