baber/WOPTO huggingface dataset:
Patent PT-2167529-E (PT)
Title: Protein layers and their use in electron microscopy
Inventor: SINCLAIR JOHN CHARLES
IPC: C07K14/11
Filed: 2008-04-23
Abstract: Protein layers 1 repeating regularly in two dimensions comprise protein protomers 2 which each comprise at least two monomers 5, 6 genetically fused together. The monomers 5, 6 are monomers of respective oligomer assemblies 3, 4 into which the monomers are assembled to assembly of the protein layer. The first oligomer assembly 3 belongs to a dihedral point group of order O, where O equals 3, 4 or 6 and has a set of O rotational symmetry axes of order 2. The second oligomer assembly 4 has a rotational symmetry axis of order 2. Due to the symmetry of the oligomer assemblies 3, 4, the rotational symmetry axes of each second oligomer assembly 4 is aligned with one of said set of O rotational symmetry axes of a first oligomer assembly 3 with 2 protomers being arranged symmetrically therearound. Thus, an 2-fold fusion between the oligomer assemblies 3, 4 is produced and the arrangements of the rotational symmetry axes of the oligomer assemblies 3, 4 cause the protein layer to repeat regularly. The protein layer has many uses, for example to support molecular entities for biosensing, x-ray crystallography or electron microscopy.
Patent PT-501725-E (PT)
Inventor: JEFFRIES ANDREW
IPC: B05D1/04
Filed: 1992-02-24
Abstract: Relatively low resistivity liquids are formed into sprays under the influence of an applied electric field acting between a nozzle 10 and the surroundings (e.g. at earth potential. The liquid issues from the nozzle as a ligament which is caused to undergo necking to a smaller diameter than that of the nozzle orifice 14, thereby producing droplets with a volume median diameter less than the orifice diameter.  <IMAGE>
Patent PT-627933-E (PT)
Inventor: MILLER ARIEL
IPC: A61K38/095
Filed: 1993-02-25
Abstract: The invention is directed to a method of treating a T cell-mediated autoimmune disease in animals, including humans, by the oral or enteral administration of autoantigens, fragments of autoantigens, or analogs structurally related to those autoantigens, which are specific for the particular autoimmune disease. The method of the invention includes both prophylactic and therapeutic measures.
Patent PT-750502-E (PT)
Inventor: NOWICKY WASSYL
IPC: A61P3/02
Filed: 1995-03-20
Abstract: PCT No. PCT/AT95/00055 Sec. 371 Date Jul. 9, 1996 Sec. 102(e) Date Jul. 9, 1996 PCT Filed Mar. 20, 1995 PCT Pub. No. WO95/25522 PCT Pub. Date Sep. 28, 1995The invention concerns the use of phosphorus derivatives of alkaloids of the general formula (I), for preparing a medicament for treating endocrinopathies, in particular for treating osteoporosis.
Patent PT-814784-E (PT)
Inventor: CAVANAUGH PAUL FRANCIS
IPC: A61K9/00
Filed: 1996-02-21
Abstract: The present invention provides novel methods for prevention or treatment of primary and recurring squamous cell carcinoma of the oral cavity or oropharynx comprising topical administration, to the oral cavity or oropharynx, of an effective amount of an NSAID, especially a composition administering from about 0.001% to about 0.2% ketorolac to the oral cavity, alone or as an adjunct to surgery and/or radiation therapy.
Patent PT-828560-E (PT)
Inventor: WARNER BRIAN D
IPC: B01L3/00
Filed: 1996-05-29
Abstract: A cover effective to releasably seal a multiwell container, such as a microtitration plate, is disclosed. The cover contains a pad, fashioned from a flexible polymer sheet, and a plurality of resiliently compressible ridges formed on the sheet. The ridges are deformable, such that application of pressure applied to the cover is effective to form a fluid-tight seal between the pad and the well openings. The ridges extend from the pad sufficiently to break the seal upon release of the pressure.
Patent PT-862520-E (PT)
Inventor: KELDERS JOHANNES HUBERTS JOZEF
IPC: A45D34/04
Filed: 1996-11-11
Abstract: PCT No. PCT/NL96/00443 Sec. 371 Date Jul. 9, 1998 Sec. 102(e) Date Jul. 9, 1998 PCT Filed Nov. 11, 1996 PCT Pub. No. WO97/17213 PCT Pub. Date May 15, 1997The invention relates to a dispensing cap for a liquid container provided with an applicator fixed thereto and for insertion into an opening of the liquid container. The dispensing cap has a closable outlet opening in its outer end located opposite the applicator. The opening is connected along a channel running through the dispensing cap to a feed aperture arranged in the vicinity of the applicator. A closing member co-acts with the feed aperture. The invention likewise relates to a liquid container provided with a dispensing cap of the above described type.
Patent PT-787638-E (PT)
Inventor: MARTIN MICHAEL
IPC: B61K3/00
Filed: 1997-01-29
Abstract: The present invention relates to a device for spraying lubricating grease onto a side wall 2 of railway tracks comprising at least one spraying element 1 supplied with lubricating grease by a pump 7 connected to a tank 11. The device is also provided with an apparatus 12 able to detect the arrival of a train. A central control unit 13 is also provided, being operationally associated with the spraying element 1, the pump 7 and the apparatus 12 so as to activate a phase sequence suitable for causing at least one jet of grease to be sprayed onto the railway track. The central control unit 13 is connected to a power supply unit which advantageously may consist of photovoltaic-cell panels 13 supplying an accumulator 15. <IMAGE>
Patent PT-973715-E (PT)
Inventor: SMUDA HEINRICH
IPC: C07C27/02
Filed: 1997-12-02
Abstract: A subject of the invention is the method of recovery of terephthalic acid and ethylene glycol from poly/ethylene terephthalate/wastes. According to the invention poly/ethylene terephthalate/ is heated in an aqueous solution at the temperature from 150° C. to 280° C. with a reagent substance, chosen from the group, comprising bicarbonates of ammonia and alkali metals, ammonium carbamate and urea, which substances are used in amounts not less than a stoechiometric amount.
Patent PT-910405-E (PT)
Inventor: DOUVAS ANGELINE
IPC: A61P37/04
Filed: 1997-03-14
Abstract: The present invention provides a vaccine comprising a caprine arthritis-encephalitis virus (CAEV) immunogen and a pharmaceutically acceptable carrier. The invention also provides a method of stimulating an immune response in an individual against human immunodeficiency virus-1 infection or against CAEV infection by administering a therapeutically effective amount of a CAEV immunogen to the individual. The invention further provides a method of stimulating an immune response in vitro by contacting a lymphocyte with a therapeutically effective amount of a CAEV immunogen. Methods of diagnosing CAEV infection in humans are also provided.
Patent PT-958816-E (PT)
Inventor: WESSEL KLAUS
IPC: A61K31/19
Filed: 1994-12-17
Abstract: Use of (R+)-alpha-liponic acid (I), R(-)-dihydroliponic acid (II) or their metabolites, salts, esters or amides for prodn. of medicaments for treating the following conditions is new: (1) type I diabetes mellitus; (2) type II diabetes mellitus; (3) compensated and decompensated insulin resistance; (4) sequelae or complications of diabetes mellitus, e.g. cataracts, polyneuropathy or nephropathy; (5) sequelae or complications of insulin resistance; and (6) disorders associated with limited glucose transport protein (GTP) function or reduced GTP levels. Also claimed are: (a) the medicaments of (1)-(5) in combination with other antidiabetic agents, esp. insulin; and (b) the medicaments of (1)-(6) contg. vitamin E, vitamin C, NADH, NADPH and/or ubiquinones as additives or stabilisers.
Patent PT-1071805-E (PT)
Title: Adenoviral vectors for treating disease
Inventor: JOHNSON LEISA
IPC: C12N15/09
Filed: 1999-04-19
Abstract: Adenoviral vectors, including mutant adenoviruses, that have restriction sites in the E3 region, that facilitate its partial or total deletion, or select genes contained therein, and compositions and methods for substituting heterologous gene(s), if desired, which gene(s) will exhibit an expression pattern, both in terms of timing and degree of expression, similar to the endogenous adenoviral gene that it replaces, and further optionally including mutations in other parts of the adenoviral genome, including certain E1B or E1A regions, and that have applications for diagnosing or treating disease, preferably disease involving unwanted cell growth, including cancer.
Patent SG-96692-G (SG)
Title: Fabric softener composition
IPC: C11D3/22
Filed: 1992-09-26
Abstract: Rinse-added fabric softening compositions containing a fabric softening active system at least 10% of which consists of certain di(higher alkyl) cyclic amines, and relatively low concentrations of polymeric soil release agents such as hydroxyether cellulosic polymers, copolymeric blocks of terephthalate and ethylene oxide or propylene oxide and cationic guar gums.
Patent SG-97991-G (SG)
Title: Mild detergent mousse
IPC: A61K8/31
Filed: 1991-11-20
Abstract: A mild skin-cleansing mousse-forming emulsion providing benefits in leaving the skin after washing feeling not taut and dry, but moisturized, soft and smooth. The product also provides abundant rich creamy foam. The cleansing mousse emulsion comprises: A. 88% to 97% of a concentrate containing by weight of the concentrate: 1. from 3% to 20% of a mild nonsoap anionic or amphoteric surfactant;  2. a polymeric skin feel aid at 0.05% to 5%;  3. a moisturizer at 10% to 60%, preferably glycerin;  4. the balance water; and B. from 3% to 12% of a propellant by weight of the total emulsion.
Patent SG-50306-G (SG)
Title: Electrical distribution system
IPC: H02G3/04
Filed: 1982-03-03
Abstract: © An electrical distribution system comprises a conduit (10) containing a plurality of continuous conductors (21, 22, 23). Spaced apertures (34) are provided in one wall of the conduit to allow access to the conductors for a connecting plug (26). A safety mechanism incorporating safety door means intended to prevent contact with the conductors by means other than the correct plug is provided at each entry point, and to facilitate assembly and servicing of the system this mechanism comprises a unitary assembly (32) which can be inserted into or removed from the conduit as a self-contained unit.
Patent IE-38759-L (IE)
Title: Light granular material
IPC: C04B35/622
Filed: 1974-01-16
Abstract: Light granular material is manufactured from silico-aluminous material by crushing and/or screening the silico-aluminous material to a fine powder which is mixed with water to form a slip which is divided into drops which are immediately introduced into a hot fluidised bed. The water evaporates rapidly and the drops are converted into expanded granules which are recovered and subjected to ceramic firing.
[US4057605A]
Patent IE-810315-L (IE)
Title: Indane derivatives
IPC: C07D295/00
Filed: 1981-02-17
Abstract: 1-Piperazino-3-phenylindane derivatives of the formula: 
<CHEM>
 wherein R<1>, R<2>, R<3> and R<4> are as defined in Claim 1, and their pharmaceutically acceptable acid addition salts. 
<??>The compounds are prepared by the usual methods for analogous compounds. 
<??>They have been found to have psychopharmacological and analgetic activity. 
<??>Pharmaceutical compositions containing the compounds have been disclosed.
Patent IE-36232-L (IE)
Title: Pyrazolidinyl phenylphosphoric acid and salts
IPC: C07F9/6503
Filed: 1972-03-28
Abstract: 1374641 Substituted phenyl phosphoric acids and salts thereof RICHARDSON-MERRELL SpA 24 March 1972 [21 April 1971] 13959/72 Headings C2P and C2C The invention comprises a phosphoruscontaining pyrazolidine dione derivative having the formula and its pharmaceutically acceptable organic and inorganic salts. The free acid is obtained by reacting the corresponding 2-(p-hydroxy phenyl)-1-phenyl pyrazolidin 3,5-dione derivative with POCl 3 in an aprotic solvent at 0-50[] C. in the presence of a base which forms a salt with HCl, cooling the mixture, adding water, drying the mixture, neutralizing the residue with aqueous MgO and then desalting the solution with an ion exchange resin or purifying by chromatography, e.g. over a resin. The calcium salt may be obtained by cooling the reaction mixture from the POCl 3 reaction step, filtering and then dissolving the precipitate in water having a highly alkaline pH obtained by adding CaO or Ca(OH) 2 to the water. The resulting solution is then concentrated and a water-miscible solvent such as methanol, ethanol or acetone added to precipitate the calcium salt which may contain up to 14 mols of water of crystallization. The calcium salt may be converted to the free acid by use of an ion exchange resin and the sodium salt may be obtained from the free acid by adding a solution of NaOH, Na 2 CO 3 or NaHCO 3 , concentrating the solution and then lyophilizing. Salts with organic bases can also be obtained by adding the base dissolved in a watermiscible solvent to an aqueous solution of the free acid. Examples are given for the production of (1) the calcium salt of the formula in its anhydrous form and in its 8H 2 O and 14H 2 O hydrate forms and also for the enzymatic hydrolysis of the 8H 2 O hydrate form by means of a phosphatase to form the free acid, viz. 4-n-butyl-2-(p-hydroxyphenyl)-1-phenyl- 3,5-pyrazolidindione, (2) the free acid of Formula I, (3) the bisodium salt in the form of its tetrahydrate, and (4) the .alpha.-p-phenetidino- N-n-propyl propionamide salt of the free acid of Formula I. The products have therapeutic properties and may be used in admixture with a pharmaceutically acceptable carrier. (From GB1374641 A) [FR2133975A1]
Patent IE-44886-L (IE)
Title: Quinoline carboxylic acid esters
IPC: A61P37/08
Filed: 1977-02-25
Abstract: The preparation of compounds of the formula I <IMAGE> is described. The process is based on reaction of the corresponding compounds of the formulae II and III <IMAGE> The compounds are used as pharmaceuticals, especially as antiallergics.
[GB1572920A]
Patent IE-790551-L (IE)
Title: Imidazolidinyl-cephem-carboxylic acid.
IPC: C07D/
Filed: 1979-08-08
Abstract: NEW MATERIAL:A compound of formula I (R1,2 are H, lower alkyl, aralkyl, etc,; R1 and R2 may together form a bifunctional hydrocarbon group which may contain a hetero-atom in the main chain; M<+> is H<+>, organic or inorganic cation). EXAMPLE:7beta-(2,2-Dimethyl-5-oxo-4-phenylimidazolidin-1-yl)-3-chloro- cephem-4- carboxylic acid. USE:Antibiotic agent which is easily crystallizable, stable, and storable for a long period. The hydrolysis of the compound I gives a compound II which is also an antibiotic agent (cephachlor) and is a raw material of the compound I. The compound I is also useful as a synthetic intermediate of a compound prepared by the esterification of the compound II. PROCESS:The compound I is prepared by reacting cephachlor II or its salt with an aldehyde or ketone III in a solvent preferably with heating.
[JP54112892A]
Patent IE-830572-L (IE)
Title: Osmotic drug delivery system
IPC: A61M31/00
Filed: 1983-03-16
Abstract: An osmotic drug (or other beneficial substance) delivery device comprises a compartment with a chamber formed by an external shell (2) of a microporous material, and an overlayer of a semipermeable membrane (1) substantially covering the outer shell (2) of the chamber. Osmotic agents, adjuvants enzymes, drugs, pro-drugs, pesticides and the like are incorporated in the chamber covered by the semipermeable membrane, and external fluids that diffuse into this chamber form solutions and by osmotic pressure are forced through the exposed microporous shell (2) to the exterior of the device at a rate controlled by the permeability of the semipermeable overlay and the osmotic pressure gradient across the shell.
[EP0180708A1]
Patent IE-810575-L (IE)
Title: Tube manufacture.
IPC: B29C57/00
Filed: 1981-03-16
Abstract: Method and apparatus for producing a tube containing sand particles bonded by a thermosetting resin. Examples of such resin include unsaturated polyesters and epoxy resins. Further, the sand core can be bonded by reinforcing material on the inner and outer surfaces of the sand core. The products are useful in situations where liquid or gaseous corrosive or abrasive materials are conveyed. Additional utility will be found in the sewer and water distribution markets.
[EP0036184A2]
Patent FI-830435-L (FI)
Inventor: MATHGEN GEORGE
IPC: H05B7/12
Filed: 1983-02-08
Abstract: A seal for use around a rod electrode passing along an axis through a hole in the wall of a furnace into the interior of the furnace has an annular and at least limitedly flexible seal ring fitted snugly around the electrode in the hole and a holder carrying the seal ring and sealingly engaged with the furnace wall. Thus gas flow through the wall at the hole past the seal ring is substantially blocked. The seal assembly has structure forming with the electrode and seal ring a substantially closed chamber surrounding the electrode axially inward into the furnace from the ring. This chamber is pressurized at superatmospheric pressure with an inert gas and the electrode is cooled inward of the furnace from the seal ring. The seal ring is compressed axially by a packing assembly so it is pressed radially against the electrode. The packing includes rigid split compression rings bearing axially on the seal ring.
Patent FI-844811-L (FI)
Inventor: NURMINEN MATTI PEKKA
IPC: B65G67/04
Filed: 1984-12-05
Abstract: The invention relates to a method and an apparatus for the transfer of concrete panels onto a transportation bed for transportation. According to the method, the transportation bed is driven to underneath the load to be transferred, the supports (1) are subsequently inclined in their transverse direction until they transfer the load onto the bed. In accordance with the invention, supports (1, 7, 6) are used, the leg members (1, 7) of which are provided with tilting joints (8, 9) in the direction of inclination, said joints being preferably fitted at the lower ends of the vertical supports (1), at the joints between the vertical supports (1) and the horizontal beams (7). The vertical supports (1) of the leg members (1,7) of the stands (1, 7, 6) are preferably inclined by about 30 DEG by connecting one of the stands with a pulling bar to the transportation bed and by pulling the load on the supports forward in this manner. The inclining movement of the stands is damped by a spring (15) or a shock absorber, installed between the vertical support (1) and the horizontal beam (7), whereby the concrete panels can be transferred by means of a controlled and attenuated movement onto the transportation bed.
Patent IE-41341-L (IE)
Title: Arranging originals to be copied on a support.
IPC: G03B27/62
Filed: 1975-05-22
Abstract: 1512724 Locating originals on supports HOECHST AG 21 May 1975 [24 May 1974] 21971/75 Heading B6C A device for locating originals to be copied on a support comprises a base dividing elements forming a plurality of compartments on the base, and means for lifting originals contained in the compartments into contact with the support as it is held above the compartments. In one embodiment, Fig. 3, a frame 3 surrounds a base-plate 2 and by means of screws 5 holds a grid 4 of dividing elements so as to define a plurality of areas forming compartments on base 2. A plurality of pads 6 corresponding to the defined areas are liftable under the action of hydraulic device (11) and elevator platform (9) Figs. 1 and 2 (not shown). The intended support, e.g. a mounting sheet 12, covered with adhesive is held by vacuum on plate 7 hinged at 8 to the device. In use, an original or a stack thereof in pre-arranged order is placed in each compartment, and the pads elevated to bring the originals or topmost originals in desired registration onto support 12 hinged over the device; the process. can be repeated for subsequent originals in the stacks, e.g. in the production of layouts, for book pages. In an alternative embodiment, Fig. 4 (not shown) the dividing elements are studs (13), embedded in the base 2; some of the studs may be removably mounted in boxes (16).
[GB1512724A]
Patent IE-781273-L (IE)
Title: Fine-particulate water-insoluble alkali metal silicates for¹washing hides.
IPC: C14C1/00
Filed: 1978-06-26
Abstract: In the process of washing and cleaning rawhides and fur skins before tanning comprising subjecting rawhides and fur skins to the action of an aqueous solution containing (1) surface-active compounds selected from the group consisting of anionic surface-active compounds, nonionic surface-active compounds and mixtures thereof, (2) emulsifiable solvents for fats and (3) electrolytes, removing said aqueous solution, rinsing, and recovering washed and cleaned rawhides and fur skins, the improvement consisting essentially of employing a fine-particulate, water-insoluble alkali metal aluminosilicate, containing bound water, of the formula (M2O)x.Al2O3.(SiO2)y wherein M represents an alkali metal, x is an integer from 0.7 to 1.5 and y is an integer from 0.8 to 6, said aluminosilicates having an average particle size in the range of from 0.1 to 25 mu and a calcium binding power of from 20 to 200 mg CaO/gm of anhydrous active substance measured at 22 DEG C. according to the Calcium Binding Power Test Method set out in the specification, as partial or total replacement of said electrolyte and optionally partial replacement of said surface-active compounds, whereby the pH of said aqueous solution is maintained between 6.5 and 8.5.
[US4210416A]
Patent IE-39525-L (IE)
Title: Catheter valve.
IPC: A61M39/26
Filed: 1974-06-24
Abstract: 1466242 Valves MATBURN (HOLDINGS) Ltd 21 June 1974 [29 June 1973] 30966/73 Heading F2V In a catheter valve, opened by the attachment of a syringe 5 to an inlet 4, a valve closure member 7 which may be of rubber or rubber-like plastics material has an integral resilient biasing element 9 urging the closure element towards a seat 6. The end of the biasing element bears against a valve retaining means 10 in the form of a plurality of inwardly directed lugs. The end of the syringe engages a spigot 8 on the closure member which is guided by three inwardly projecting ribs in the valve body 1.
[GB1466242A]
Patent IE-35841-L (IE)
Title: Coating process
IPC: C08J7/043
Filed: 1971-11-22
Abstract: Pre-treatment of a metal, especially aluminum or zinc, prior to painting, by means of a complex halogen-containing phosphorus or aluminum containing chemically-bound molecules of water and/or an organic hydroxy compound. The preferred complex phosphate contains ethyl alcohol molecules and has an empirical formula of A1PC1H25C8O8, and is most conveniently used in solution in methyl alcohol or ethyl alcohol.
[US3772060A]
Patent IE-891592-L (IE)
Title: Guidewire extension with self-latching detachable connector
IPC: A61B19/00
Filed: 1989-05-17
Abstract: A guidewire system (12) for use in catheter exchanges avoids the need for a separate exchange wire (20) by connecting an extension wire (30) to the proximal end of the guidewire thereby increasing the effective length of the guidewire to permit a catheter exchange. The proximal end of the guidewire is attached to the distal end of the exchange wire by a disconnectable reattachable connection which avoids deformation of the connected joint.
[EP0347035A2]
Patent IE-41311-L (IE)
Title: Substituted ethylenylphenoxy-2, 2-dimethyl acetic acid¹derivatives
IPC: C07C255/37
Filed: 1975-08-07
Abstract: This invention is concerned with compounds of the formula CN CH3 C=CH O-C-CO2R1 R2 CH3 wherein R1 is hydrogen or lower alkyl and R2 is phenyl, halophenyl, trifluoromethylphenyl, p-[2-(lower alkoxy)carbonyl-2-oxypropyl]phenyl or 3,4,5-tri-(lower alkoxy)=phenyl. The compounds of this invention are prepared by the condensation of ethyl (4-formylphenoxy)-2,2-dimethylacetate with an appropriate substituted phenyl=acetonitrile. The compounds of the present invention are useful as hypolipemic agents.
[US3903132A]