baber/WOPTO huggingface dataset:
Patent WO-2020227177-A1 (WO)
Inventor: JAIN Rajul
IPC: A61K38/34
Filed: 2020-05-03
Abstract: The disclosure provides cells comprising CD19-directed chimeric antigen receptor (CAR) genetically modified autologous T cell immunotherapy for the treatment of, e.g., relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma, high grade B-cell lymphoma, and DLBCL arising from follicular lymphoma. Some aspects of the disclosure relate to methods of treatment and monitoring following infusion of T cell therapy provided herein.
Patent WO-2020232269-A1 (WO)
Inventor: CHEN JIANLE
IPC: H04N19/513
Filed: 2020-05-14
Abstract: A method of decoding includes determining, by the video decoder, whether a resolution of a current picture being decoded is the same as the resolution of reference pictures identified by a reference picture list associated with the current picture; enabling, by the video decoder, decoder-side motion vector refinement (DMVR) for a current block of the current picture when the resolution of the current picture is determined to be the same as the resolution of each of the reference pictures; disabling, by the video decoder, the DMVR for the current block of the current picture when the resolution of the current picture is determined to be different than the resolution of either of the reference pictures; and refining, by the video decoder, motion vectors corresponding to the current block using the DMVR when the DMVR flag is enabled for the current block.
Patent WO-2020236800-A1 (WO)
Inventor: ERNENWEIN KEITH M
IPC: B60B7/06
Filed: 2020-05-19
Abstract: A hubcap for a heavy-duty duty vehicle that includes mounting structure that is formed with and cooperates with a side wall of the hubcap to provide a stiff, rigid structure that enables non-cantilevered connection to a wheel hub. The mounting structure can be a plurality of elongated bosses circumferentially spaced about the side wall that are formed with corresponding elongated bolt openings to enable the non-cantilevered attachment to the wheel hub. The elongated bosses cooperate with the hubcap side wall to provide a stiffened or rigid structure between the elongated bolt openings for increased and more uniform clamping force on a sealing gasket between the hubcap and the wheel hub. The hubcap profile provides clearance for removal of an outboard mounted disc brake rotor in heavy-duty vehicle wheel end assemblies that include such rotor configurations. The hubcap may support simple mounting of a hubodometer.
Patent WO-2020247390-A1 (WO)
Title: Oil-based mud contamination estimate from physical properties
Inventor: DIFOGGIO ROCCO
IPC: G01N33/24
Filed: 2020-06-02
Abstract: Methods and apparatus for estimating a presence of oil-based mud (OBM) in a downhole fluid. Methods include generating measurement values by measuring one or more gross physical properties of the downhole fluid with at least one sensor, the measurement values comprising at least one measurement value representative of each gross physical property; and estimating with at least one processor a relative concentration of OBM with respect to the downhole fluid by using a model correlating the measurement values with the relative concentration. Methods may include taking measurements from the downhole fluid in situ and/or estimating the relative concentration in real-time with respect to generating the measurement values. The model may comprise a correlation prediction function mapping the measurement values to the relative concentration, which may use the measurement values as input to predict the relative concentration.
Patent WO-2020247507-A1 (WO)
Inventor: ARTHUR RICHARD
IPC: C10G1/04
Filed: 2020-06-03
Abstract: A radial flow oil shale retort (100) can include a central heating fluid conduit (118) having a permeable outer wall (132) and an outer heating fluid annulus (116) positioned about the central heating fluid conduit (118), the outer heating fluid annulus (116) having a permeable inner wall (130). An annular body (114) of comminuted oil shale can be between the permeable outer wall (132) of the central heating fluid conduit (118) and the permeable inner wall (130) of the outer heating fluid annulus (116). A heating fluid supply (122) can be connected to either the central heating fluid conduit (118) or the outer heating fluid annulus (116) to flow a heating fluid in a radial direction through the annular body (114) of the comminuted oil shale.
Patent WO-2020263687-A1 (WO)
Inventor: MASSIMINI DANIEL
IPC: A61B18/26
Filed: 2020-06-18
Abstract: A catheter system (100) for pressure wave and inertial impulse generation for disruption of an intravascular lesion includes a catheter (101) having a balloon (122) coupled to an elongate shaft (102), a first light guide (1202) and a second light guide (1204). The light guides (1202, 1204) are disposed along the elongate shaft (102). The light guides (1202, 1204) can each include a diverting feature (802, 804, 806) in optical communication with at least one light window (706) to direct light to exit each light guide (1202, 1204) toward a side surface portion (722) thereof and toward the balloon (122). A method includes advancing the catheter (101) to a treatment site (1014), expanding the balloon (122) from a collapsed configuration (1002) to a first expanded configuration (1004), and activating a light source (116) in optical communication with each light guide (1202, 1204) to provide sub-millisecond pulses of light to the diverting features (802, 804, 806), thereby inducing plasma formation in a balloon fluid (124), causing rapid bubble (130) formation, and imparting pressure waves (1016) upon the treatment site (1014).
Patent WO-2020264063-A1 (WO)
Inventor: SALUMÄE MART
IPC: B65D35/00
Filed: 2020-06-25
Abstract: Films compositions for packaging and delivering a foodstuff, pharmaceutical, industrial, manufacturing and agricultural materials and uses are disclosed. The film can be formed from at least one biodegradable film forming agent, and at least one biodegradable plasticizer. The resulting film can be formed and shaped to a variety of film package configurations and can have multi compartments. The resulting films and film packages can be edible and substantially and/or completely soluble in a cold, cool, warm and/or hot hydro-liquid including water. The film forming agent(s) is compostable and the film has an essential absence of petrochemicals and non-biodegradable plastics/bioplastics.
Patent WO-2022025904-A1 (WO)
Title: Éléments de fixation
Inventor: CHUNG TIEN LIANG
IPC: H01R12/00
Filed: 2020-07-31
Abstract: Le sujet de la présente invention concerne un élément de fixation comprenant une base et un couvercle mobile par rapport à la base. Selon un exemple, le couvercle doit coulisser au-dessus de la base pour englober au moins partiellement un composant électronique et une partie d'un module électronique dans un espace creux entre la base et le couvercle pour maintenir le composant électronique couplé au module électronique.
Patent WO-2021025974-A1 (WO)
Title: Dérivés de squalamine humaine, compositions associées les comprenant, et procédés d'utilisation correspondants
Inventor: BARBUT DENISE
IPC: A61K31/575
Filed: 2020-07-31
Abstract: La présente invention concerne d'une manière générale de nouveaux composés aminostérol, des compositions les comprenant, et des procédés de production et d'utilisation des nouveaux composés aminostérol et des compositions.
Patent WO-2022025925-A1 (WO)
Inventor: BOLEDA BUSQUETS MIQUEL
IPC: G01L7/08
Filed: 2020-07-31
Abstract: An example printing fluid pressure sensor comprises a first pressurizable chamber having an inlet to receive a pressurized gas and a second chamber to receive a printing fluid. A flexible element is disposed in between the first and second chambers and is to retain a magnet. A first side of the flexible element forms a wall of the first chamber and a second side of the flexible element forms a wall of the second chamber to seal the first and second chambers. The example sensor further comprises a sensor to detect the position of a magnet relative to the sensor. The sensor is disposed outside of the first and second chambers.
Patent WO-2021030165-A1 (WO)
Inventor: FUCHTER MATTHEW J
IPC: A61K41/00
Filed: 2020-08-07
Abstract: Described herein are photoswitchable compounds that can activate TRPA1 channels in neuronal and non-neuronal cells. The TRPswitch molecules allow for optical control of both the activation and deactivation of TRPA1 channels. Such compounds can be used as research tools or therapeutics.
Patent WO-2021051009-A1 (WO)
Title: Methods and compositions to direct breakdown of insulin mrna in benign fashion
Inventor: ROEP BART OTTO
IPC: A61K39/39
Filed: 2020-09-11
Abstract: Methods and compositions discussed herein allow for preventing or treating type 1 diabetes (T1D) including directing the breakdown of insulin mRNA.
Patent WO-2021067515-A1 (WO)
Inventor: PIESTUN RAFAEL
IPC: G02B27/48
Filed: 2020-09-30
Abstract: Systems and methods are provided for imaging and characterizing objects including the eye using non-uniform or speckle illumination patterns. According to the present technology, a method for characterizing at least a portion of an object may include generating, using at least one light source, one or multiple non-uniform illumination patterns on an object. The method may also include detecting, using a detector, backscattered light from the object in response to the generating. The method may further include extracting, using the detector, data representative of the backscattered light. The method may also include processing, using a processing unit, the data representative of the backscattered light to create one or more images of at least a portion of the object.
Patent WO-2021077064-A1 (WO)
Inventor: PEDIADITAKIS IOSIF
IPC: B01L3/00
Filed: 2020-10-19
Abstract: The invention relates to modeling brain neuronal disease in a microfluidic device, comprising a co-culture of iPS-derived brain endothelial cells; iPS-derived dopaminergic neurons; primary microglia; and primary astrocytes, a Blood-Brain-Barrier (BBB)-Chip and a Brain-Chip. In particular, cross-talk between glial cells (e.g. microglia and astrocytes) with neuronal cells, in further contact with endothelial cells is contemplated for use for identifying drug targets under conditions for inducing in vivo relevant neuronal inflammation, neurodegeneration and neuronal death. Thus, in one embodiment, a microfluidic Brain-Chip comprising a co-culture of brain cells is exposed to a-synuclein preformed fibrils (PFF), a type of pathogenic form of a-synuclein. Such a-synuclein PFF exposure demonstrates an in vivo relevant disease pathogenesis on a microfluidic device as a concentration- and time-controlled manner that may be used for preclinical drug evaluation for diseases related to neuronal inflammation, e.g. Parkinson's disease (PD).
Patent WO-2021096700-A1 (WO)
Inventor: BENDAVID YORAM
IPC: G06F3/0354
Filed: 2020-10-30
Abstract: L'invention concerne un appareil et un procédé pour fournir une structure et une fonction, respectivement, à un dispositif d'écriture, de lecture ou de pointage portatif à stylet pour permettre l'utilisation du dispositif pour effectuer des opérations similaires à une souris d'ordinateur pour un dispositif informatique. La structure comprend un capteur optique, un élément de détection de pression pour détecter une pression pour détecter une action de clic de souris et un capteur d'orientation pour commuter le stylet d'un mode de fonctionnement avec un stylet à un mode de fonctionnement avec une souris.
Patent WO-2021101844-A1 (WO)
Inventor: DEDONATO AMY
IPC: G06T17/10
Filed: 2020-11-16
Abstract: An augmented reality (AR) device can be configured to generate a virtual representation of a user's physical environment. The AR device can capture images of the user's physical environment to generate or identify a user's location. The AR device can project graphics at designated locations within the user's environment to guide the user to capture images of the user's physical environment. The AR device can provide visual, audible, or haptic guidance to direct the user of the AR device to explore the user's environment.
Patent WO-2021102052-A1 (WO)
Inventor: RASTELLI LUCA
IPC: A61K47/68
Filed: 2020-11-18
Abstract: Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates.
Patent WO-2021119098-A1 (WO)
Inventor: SRIDHAR ARUN
IPC: A61N1/05
Filed: 2020-12-09
Abstract: The present disclosure provides an apparatus for stimulating neural activity in a pudendal nerve of a subject, the apparatus comprising of: at least one primary electrode configured to apply a first electrical signal to said nerve; and a controller coupled to said primary electrode (s) and controlling the first electrical signal to be applied thereby, wherein said controller is configured to cause said at least one primary electrode to apply said first electrical signal that stimulates neural activity in the pudendal nerve to improve bladder function, and wherein the first electrical signal is applied in a burst pattern.
Patent WO-2021119241-A1 (WO)
Inventor: CARRESE EDWARD
IPC: B03C1/04
Filed: 2020-12-10
Abstract: Disclosed herein are embodiments of a fixed magnet assembly that can be implemented into automated platforms for performing polynucleotide extraction from biological samples and preparing the polynucleotides into an amplification-ready form. The fixed magnet assembly can be used to provide magnetic energy to a container containing magnetic particles and a reaction mixture of polynucleotides, in order to bring about a separation of the magnetic particles from the reaction mixture. This can prevent or reduce magnetic particle carryover in the prepared amplification-ready sample, thereby improving amplification results.
Patent WO-2021119252-A1 (WO)
Inventor: KIM TAESEOK
IPC: H01L31/0224
Filed: 2020-12-10
Abstract: Aligned metallization approaches for fabricating solar cells, and the resulting solar cells, are described. In an example, a solar cell includes a semiconductor layer over a semiconductor substrate. A first plurality of discrete openings is in the semiconductor layer and exposes corresponding discrete portions of the semiconductor substrate. A plurality of doped regions is in the semiconductor substrate and corresponds to the first plurality of discrete openings. An insulating layer is over the semiconductor layer and is in the first plurality of discrete openings. A second plurality of discrete openings is in the insulating layer and exposes corresponding portions of the plurality of doped regions. Each one of the second plurality of discrete openings is entirely within a perimeter of a corresponding one of the first plurality of discrete openings. A plurality of conductive contacts is in the second plurality of discrete openings and is on the plurality of doped regions.
Patent WO-2021158304-A1 (WO)
Title: Methods and apparatus to decrease domain name system (dns) lookup time for airborne clients
Inventor: PETERSON JAMES
IPC: H04L29/08
Filed: 2020-12-21
Abstract: Methods and apparatus to decrease DNS lookup times for mobile clients are disclosed. An example DNS cache peering system includes a mobile DNS cache; a mobile DNS server configured to, when an IP address for a URL is not found in the DNS cache, send a DNS lookup request for the URL; a ground-based DNS server to receive the DNS lookup request from the mobile DNS server, and send, in response, a DNS lookup response including the IP address for the URL to the mobile DNS server; and a ground-based DNS peer engine server configured to capture the DNS lookup response, and multicast DNS information from the DNS lookup response to a plurality of mobile DNS peer engine clients, wherein the plurality of mobile DNS peer engine clients are configured to store the DNS information in respective ones of a plurality of mobile DNS caches.
Patent WO-2021138142-A1 (WO)
Title: A non-dairy creamer and method of making the same
Inventor: CHANG GUIFANG
IPC: A23C11/02
Filed: 2020-12-22
Abstract: The present invention relates to a non-dairy creamer including a triglyceride composition. The triglyceride composition includes triglycerides having a specific fatty acid profile. The triglyceride composition has a trans fatty acid value of from about 0wt% to about 1wt% by weight of the total fatty acid content, an oxidative stability index of greater than about 15h at a temperature of 120 °C and an airflow rate of 20L/h, a saturated fatty acid content of from about 55wt% to about 65wt% by weight of the total fatty acid content, a slip melting point of from about 22 °C to about 40 °C, and a total volatile aldehyde content of from about 1wt% to about 5wt% by weight of the triglyceride composition.
Patent WO-2021146621-A1 (WO)
Title: A catheter insertion tool
Inventor: ZIMMER BRIAN
IPC: A61M25/01
Filed: 2021-01-15
Abstract: Embodiments disclosed herein are directed to an insertion tool (100) for a catheter. The insertion tool (100) engages a proximal end of an introducer (10) and includes a guide channel (106) that aligns with a lumen of the introducer (10). The guide channel (106) supports the catheter (50) to maintain columnar integrity as the catheter (50) is urged distally, past a valve and into the lumen of the introducer (10). In an embodiment, the attachment structure can be inserted past the valve to define a pathway for the catheter. Embodiments also include an elongate opening to allow lateral ingress/egress of the catheter, a segmented cylindrical shape to provide a shortened elongate opening, and an offset elongate opening to allow a rolling introduction of the catheter to the guide channel to prevent abrasion of any coatings disposed on the catheter.
Patent WO-2021151005-A1 (WO)
Title: Inhaled das181 to treat cancer in the lung
Inventor: HO JENNIFER
IPC: A61K38/47
Filed: 2021-01-22
Abstract: Provided herein are methods of treating lung cancer by administering a therapeutically effective amount of a polypeptide having sialidase activity, e.g., DAS181, topically to the lungs, wherein the method of administration includes inhalation of a dry powder formulation containing, e,g,. DAS181 with a metered dose inhaler and/or inhalation of a liquid nebulized formulation containing, e.g., DAS181 with a nebulizer.
Patent WO-2021154701-A1 (WO)
Inventor: SUNG SHIANG
IPC: B01J23/42
Filed: 2021-01-26
Abstract: Sont divulgués ici des compositions de catalyseur d'oxydation comprenant un premier composant de métal du groupe du platine (PGM), un composant de manganèse (Mn), un premier matériau de support d'oxyde métallique réfractaire, et un composant métallique comprenant de l'yttrium, du lanthane, de l'étain, du magnésium, du cérium, du titane, ou une combinaison de l'un quelconque des éléments précédents, chacun du premier composant PGM, du composant Mn et du composant métallique étant supportés sur le premier matériau de support d'oxyde métallique réfractaire ; des articles de catalyseur revêtus d'au moins une telle composition de catalyseur ; et des systèmes de traitement d'émission comprenant au moins un tel article de catalyseur.
Patent WO-2021174224-A1 (WO)
Inventor: RIERA MICHAEL
IPC: G06T11/20
Filed: 2021-03-01
Abstract: A stand-alone accelerator protocol (SAP) for heterogeneous computing systems is provided. The adoption of emerging accelerators is key to achieving greater scale and performance in heterogeneous computing systems. The SAP allows for a hardware accelerator to be plug-and-playable in a stand-alone fashion (without needing a local central processing unit (CPU) host) and interact with a remote computing system agent for application acceleration across any network infrastructure. The SAP further facilitates a hardware-agnostic accelerator orchestration (HALO) software framework for hardware-agnostic programming with high performance portability and scalability in heterogeneous computing systems, such as high-performance computing (HPC) systems, data center computing systems, and edge computing systems. Accordingly, embodiments described herein provide a flexible hardware-agnostic environment that allows application developers to develop high-performance applications without knowledge of the underlying hardware. This environment facilitates dynamic plugin of an accelerator onto the network fabric, which can be auto-discovered and utilized by applications.
Patent WO-2022186828-A1 (WO)
Inventor: RAMAN NATRAJ
IPC: G06Q10/00
Filed: 2021-03-03
Abstract: L'invention concerne un procédé et un système permettant de vérifier qu'un processus est conforme à une norme, telle qu'une régulation gouvernementale ou une norme de qualité. Le procédé comprend : l'obtention de premières informations qui concernent une entité qui a exécuté un procédé, les premières informations comprenant une identification d'entité, une norme, et au moins un document qui concerne un résultat d'une exécution du premier procédé ; l'extraction d'un type spécifique d'informations à partir du ou des documents ; et la détermination, sur la base des informations extraites, de si l'exécution du procédé par l'entité satisfait la norme. Le procédé peut également comprendre la détermination d'une valeur de niveau de confiance qui concerne un degré d'incertitude de la détermination du fait que la norme a été satisfaite ou non, et la valeur de niveau de confiance peut être utilisée pour ajuster la norme et/ou pour ajuster le procédé de vérification.
Patent WO-2021188384-A1 (WO)
Inventor: SMITH DUANE
IPC: C12N15/09
Filed: 2021-03-12
Abstract: L'invention concerne des méthodes d'amplification de séquences de transcription appariées à partir d'une seule cellule, comprenant, entre autres, des séquences de récepteur de lymphocytes T (TCR) alpha et bêta à partir d'un seul lymphocyte T. La méthode peut comprendre les étapes consistant à : placer un lymphocyte T unique dans une solution de lyse cellulaire pour fournir un lysat de lymphocytes T comprenant de l'ARN ; générer un ADNc premier brin à partir de l'ARN ; amplifier l'ADN premier brin pour fournir un ADNc amplifié ; et amplifier les séquences de TCR alpha et bêta à partir de l'ADNc amplifié en une seule réaction, les séquences de TCR alpha et bêta étant amplifiées à l'aide de trois ensembles d'amorces d'amplification de TCR. Dans certains cas, les méthodes peuvent être effectuées en n'utilisant pas plus de six ensembles d'amorces.
Patent WO-2021203057-A1 (WO)
Title: Powder hydration systems with mixing apparatus and methods of use
Inventor: JONES NEPHI
IPC: B01F5/04
Filed: 2021-04-02
Abstract: A powder mixing system (12) includes a conduit (40) having a first end and an opposing second end, the conduit bounding a passage; a fluid pump (80) fluid coupled with the conduit, the fluid pump being configured to pump a liquid through the passage of the conduit; and a tubular transfer member (190) in fluid communication with the conduit, the transfer member being configured to couple with a powder bag housing a powder. The mixing system further including: (1) an eductor coupled to the transfer member and disposed in-line with the conduit so that the liquid pumped through the conduit also passes through the eductor; and/or (2) an auger assembly comprising an auger blade, at least a portion of the auger assembly being rotatably disposed within the transfer member.