baber/WOPTO huggingface dataset:
Patent KR-20020060154-A (KR)
IPC: A61P43/00
Filed: 2000-08-11
Abstract: The present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated Ginkgolide B (GKB), a component of the extract of Ginkgo biloba leaves in a method for decreasing the expression of peripheral-type benzodiazepine receptor (PBR) in cells of a patient in need thereof. Further, the present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated GKB in a method for decreasing the proliferation of cancer cells in a patient. More particularly, the present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated GKB in a method of decreasing cancer cell proliferation in a patient wherein the cancer cell is human breast cancer cell. Even more particularly, the present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated GKB in method of decreasing cancer cell proliferation in a patient wherein the cancer cell is of the aggressive and invasive phenotype and expresses high levels of PBR in comparison to non-aggressive cancer cell.
Patent KR-20020041822-A (KR)
Title: Optical element holding device
IPC: G02B7/02
Filed: 2001-08-10
Abstract: A holding apparatus characterized by: 
a holding portion (42) for holding a member to be held (38), 
wherein the holding portion includes a drive mechanism (85a, 85b, 108, 143) for providing the member to be held with three movements along three coordinate axes (R, ¸, Z) with an origin being substantially the center of the member to be held and two rotations about at least two coordinate axes of the three coordinate axes.
Patent KR-20020091048-A (KR)
Title: 백래시 방지 스프래그
IPC: F01L33/02
Filed: 1999-10-19
Abstract: 구동축의 회전을 한 방향으로만 허용하기 위한 구동축 조립체가 제공된다.  구동축 조립체는 하우징, 구동축 및 오버러닝 클러치를 포함한다.  오버러닝 클러치는 외측 환형 접촉면을 갖는 내측 레이스와 상기 내측 레이스로부터 반경방향으로 이격된 내측 환형 접촉면을 갖는 외측 레이스를 포함한다.  내측 환형 접촉면 및 외측 환형 접촉면은 이들 사이에 환형 공간을 형성한다.  이같은 환형 공간 내에는 내측 레이스가 외측 레이스에 대해 제 1 방향으로 회전하는 것을 허용하는 반면 내측 레이스가 외측 레이스에 대해 제 2 방향으로 회전하는 것을 방지하는 다수개의 스프래그가 제공된다.  외측 레이스에 구동 하우징이 고정되고 내측 레이스에 구동축이 고정되어 구동축에 제 1 방향으로 회전력이 제공되면 구동축이 회전하고, 회전력이 반대방향으로 구동축에 인가되면 구동축상의 비틀림력이 오버러닝 클러치를 통해 하우징에 전달되며, 이로써 구동축이 제 2 방향으로 회전하는 것이 방지된다.  바람직한 실시예에서, 구동축은 피스톤의 직선 작동을 구동축의 회전 운동으로 변환하는 피스톤 조립체에 커플링된다.
Patent KR-20020057987-A (KR)
Title: Base station apparatus and communication method
IPC: H04W52/04
Filed: 2001-08-24
Abstract: Data portion transmission power controlling section 108 increases/decreases the transmission power of the transmitting data to communication terminal apparatus A according to TPC fromTPC command decoding section 106. Data portion transmission power controlling section 109 increases/decreases the transmission power of the transmitting data to communication terminal apparatus B according to TPC from TPC command decoding section 107. Midamble portion transmission power value determining section 100 adjusts the transmission power value to the transmission power value which is maximum among transmission power values of transmitting data to communication terminal apparatus A and communication terminal apparatus B, and controls the transmission power of a midamble portion to be transmitted commonly to all communication terminal apparatuses. <IMAGE>
Patent KR-20020082208-A (KR)
Title: Ｎ,ｏ-아미도말로네이트 백금 착화합물
IPC: A61K31/555
Filed: 2001-01-04
Abstract: 본 발명은 정제된 백금 착화합물에 관하는데, 여기서 백금은 아미도말로네이트의 단일 N,O-또는 O,O-킬레이트를 형성하게 된다.  상기 킬레이트 및 이의 제약학적으로 수용가능한 제형은 암의 치료에 유용하다.  백금 킬레이트는 하나 또는 복수의 작용기와 추가적으로 연결시킬 수 있는데, 이런 작용기는 수용성을 증가시키고 및/또는 킬레이트의 종양표적화를 지원한다.  종양 표적화 성분의 예에는 중합체(여기서, 하나 또는 복수의 백금 킬레이트는 체내에서 절단될 수 있는 링커를 통하여 중합체 골격에 부착되고) 및 종양 조직 및/또는 종양 맥관 구조에서 농축되거나 상향조절되는 수용체에 높은 친화성을 가진 분자가 포함된다.
Patent KR-20030032927-A (KR)
IPC: A61K31/70
Filed: 2001-03-15
Abstract: 뉴클레오시드 유사체 및 이들의 전구약물 형태에는 당 부분 및 헤테로사이클 염기 부분이 포함되는데, 여기에서 특히 바람직한 당 부분에는 리보푸라노즈가 포함되며, 특히 바람직한 염기 부분에는 디아졸 및 트리아졸이 포함된다.  본 발명의 화합물은, (바이러스에 의한) 감염, (기생충에 의한) 감염, 종양 또는 자가 면역 질환을 치료하는데 사용될 수 있는 약제 조성물에 사용될 수 있다.  또한, 본 발명의 용도에는 면역 조절 작용, 특히 제 1 유형 및 제 2 유형의 사이토킨 발현의 조절 작용이 포함된다.
Patent KR-20020081473-A (KR)
IPC: H02K11/33
Filed: 2001-01-20
Abstract: The device has an electrical contact arrangement (30) for making an electrical connection between the components and a mechanical connection arrangement with at least one synthetic ring (26) held in an opening (16) in a first component (2,4,6) and a journal-shaped attachment section (14) of a second component (1,8). When the journal-shaped part is inserted into the opening the ring is compressed and the electrical contact arrangement is engaged.
Patent KR-20020088422-A (KR)
IPC: B32B27/32
Filed: 2001-03-23
Abstract: A method of making a high gloss, multilayered thermoplastic film by pinning the extruding the molten thermoplastic film material onto a polished casting roll having a mirror finish. The thermoplastic film produced by this method has a superior gloss finish and has a ratio of distinctness of image in the machine direction to distinctness of image in the cross direction in the range of 1.3:1 to 1.0:1, and has a 20° gloss in the machine direction and the cross direction of at least 40.
Patent KR-20020089492-A (KR)
Title: 웨이퍼 후면에 다이 부착물질의 사전 도포
IPC: H01L21/58
Filed: 2000-11-17
Abstract: 하부 다이 접착패드의 오염을 제거하고 일정한 접착선 두께를 제공하는 적층 다이 구조의 상부 다이를 하부 다이에 접착하는 방법이 제공된다. 실시예에서, 상부 다이가 여전히 웨이퍼 형태로 있는 동안 웨이퍼의 후면으로 비스코스 형태의 에폭시를 회전(spinning)시키거나 스크리닝(screening) 함으로써 또는 웨이퍼 후면에 에폭시 필름을 씌움으로써 다이 부착물질을 적층 다이 패키지의 상부 다이에 도포한다. 다음 웨이퍼는 소잉 테이프(sawing tape)에 놓이고 다이로 분리되어 상부 다이를 포함하게 된다. 그 후 상부 다이는 하부 다이 위에 놓이고 에폭시가 경화된다. 비스코스 다이 부착물질이 하부 다이에 놓이지 않기 때문에, 다이 부착물질이 하부 다이의 접착패드로 흘러가지 않는다. 따라서, 상부 다이가 하부 다이의 상면에 부착될 때 하부의 접착영역만이 노출되도록 하부 다이의 크기가 감소될 수 있어서 적층 다이 조립품의 소형화가 가능하게 된다. 또한, 상부 다이의 전체 다이 부착영역이 소정량의 다이 접착물질에 의해 덮여 있기 때문에, 상부 다이와 하부 다이 사이의 접착선 두께는 세밀히 제어될 수 있어서 신뢰성을 향상시킨다.
Patent KR-20040066307-A (KR)
Inventor: JANG GI SUN
IPC: G02B6/40
Filed: 2003-01-17
Abstract: PURPOSE: An optical fiber array having high reliability is provided to maximize an adhesive area of a V-groove silicon wafer by forming a plurality of scratches on a surface of the V-groove silicon wafer. CONSTITUTION: An optical fiber array having high reliability includes a V-groove substrate(2), an optical fiber, a glass cover, a ribbon-shaped optical fiber(3), and a plurality of adhesive. A first coating layer and a second coating layer are removed from the optical fiber. The optical fiber(1) is loaded on the V-groove substrate. The V-groove substrate includes a front part and a rear part. The optical fiber and the glass cover(4) are fixed on the front part of the V-groove substrate. A plurality of scratches are formed on a surface of the front part in order to maximize an adhesive area.
Patent KR-20040068713-A (KR)
Inventor: LEE KWANG HEE
IPC: A63B53/04
Filed: 2003-01-27
Abstract: PURPOSE: A golf club for practice is provided to help a golfer to easily confirm the spot swing and to understand his/her swing pose by forming a determined passage in which a golf ball for practice can come in touch with the sweet spot portion of golf club head. CONSTITUTION: The golf club includes; a grip as a handle; a head(2) impacting a golf ball; and a shaft coupling the head(2) with the grip, wherein a conduit(5) is extended to the inside of the head(2), a mouth(5a) of the conduit(5) is formed on the sweet spot(4) portion of the face(6), and the conduit(5) has a curvature and is extended in the left direction when seeing the front of the face(6).
Patent KR-20040069564-A (KR)
Inventor: KWAK MIN HAN
IPC: C08K3/00
Filed: 2003-01-29
Abstract: PURPOSE: A polypropylene-layered silicate nanocomposite composition and its preparation method are provided, to improve stiffness, heat resistance, impact resistance, affinity with a polymer resin, dispersion and releasability. CONSTITUTION: The composition comprises 0.1-40 wt% of a modified polypropylene; 0.1-40 wt% of an organic layered clay; 16-99 wt% of a polypropylene resin; and 0001-4 wt% of a chain extender. Preferably the modified polypropylene is obtained by modifying at least one polypropylene selected from the group consisting of a propylene homopolymer, a propylene-α -olefin copolymer and a propylene-unconjugated diene-based compound copolymer, with a functional group, and has a weight average molecular weight of 5,000-5,000,000; and the organic layered clay is a clay substituted with an organic onium ion. The method comprises the steps of mixing an organic layered clay with a modified polypropylene and a polypropylene resin to prepare a master batch; and adding a polypropylene resin and a chain extender to the master batch and melting the mixture.
Patent KR-20040074544-A (KR)
Inventor: LIM SEONG U
IPC: F24F11/00
Filed: 2003-02-19
Abstract: PURPOSE: A multi-air conditioner and a control method thereof are provided to prevent damage, to protect environment, and to improve the reliability by restricting leakage of refrigerant and recovering refrigerant leaking from the indoor unit. CONSTITUTION: The pressure of refrigerant passing through a passage is decreased in leaking refrigerant from an indoor unit while driving a multi-air conditioner(600,603,606). A pressure sensor installed in the outlet pipe of the indoor unit detects pressure at the outlet of the indoor unit, and outputs the signal to a control unit automatically in lowering pressure below the predetermined pressure(609). The control unit regulates the opening degree of an electronic expansion valve to zero(612). A control unit of an outdoor unit operates a compressor for 2 to 3 minutes with a compressor driving unit(615). Refrigerant leaking from the indoor unit is recovered by the outdoor unit, and the error code is displayed(618).
Patent KR-20040075630-A (KR)
Inventor: CHOI CHANG JUN
IPC: G06F7/50
Filed: 2003-02-22
Abstract: PURPOSE: A CLA(Carry Lookahead Adder), based on a Manchester carry chain, and its adding method are provided to eliminate a time loss in waiting an enable signal for activating a sense amplification flipflop, and to calculate a final addition value from a bit carry selected by a block carry by using a self synchronizer. CONSTITUTION: The device comprises a carry generation/propagation module(110), a block carry module(120), a bit carry module(130), a block carry selector(140), and an addition value selector(150). The carry generation/propagation module(110) discriminates addition numbers, inputted in an N bit binary state, into M blocks, performs the first logic combination for each bit of each block, and calculates a carry propagation bit value and a carry consumption bit value. The block carry module(120) generates clock carries by performing the second logic combination for the carry consumption bit value for each bit. The bit carry module(130) calculates carries for each bit by using the Manchester carry chain and performing the fifth logic combination for the carry propagation bit value and the carry consumption bit value. The block carry selector generates block carry generation data, not controlled by any clock signal, by performing a logic combination for block carries and carry values propagated to a lower bit block. The addition carry module(150) selects a carry for each bit, adds a carry propagation bit value to the selected carry for each bit, and outputs a final addition result.
Patent KR-20040076005-A (KR)
Inventor: KIM JONG KYU
IPC: A61K9/12
Filed: 2003-02-24
Abstract: PURPOSE: A herbal extract containing an Artemisia asiatica Nakai extract as a main component is provided. It is introduced into a spray and aerosol container for aerosolization of the extract. The herbal extract is effective in alleviating pain by spraying or fomenting. CONSTITUTION: Artemisia asiatica Nakai is mixed with water in a ratio of about 1:700, heated for a specified time at 90 to 120deg.C and then filtered. The extract is concentrated, diluted with distilled water, ethyl alcohol and additives and filtered with a sieve of 350 meshes or more. The Artemisia asiatica Nakai extract is mixed with an extract of any one herbal plant selected form Cnidii Rhizoma, Angelicae Gigantis Radix, Allium ascalonicum, Rhus javanica, Sambucus williamsii Hance, Coix seeds, Ginseng Radix, Rehmanniae Rhizoma, Glycyrrhizae Radix, Phellodendron amurense, Chrysanthemum sibiricum, Hoelen and Dictamnus albus. The extract is introduced into vessel together with liquified gas.
Patent KR-20040076113-A (KR)
Inventor: CHOI JEONG DONG
IPC: H01L21/76
Filed: 2003-02-24
Abstract: PURPOSE: A method for forming a semiconductor substrate is provided to reduce fabricating cost by eliminating the necessity of an SOI(silicon-on-insulator) substrate, and to prevent a defect or a void by forming an insulation layer as an oxide layer after an epitaxial layer is formed. CONSTITUTION: At least a pair of sacrificial layers and silicon layers are sequentially formed on a semiconductor substrate(13). At least the pair of the sacrificial layers and silicon layer and a predetermined depth of the semiconductor substrate are etched by using the first mask pattern so that a semiconductor substrate having an uneven structure and at least the pair of sacrificial layer patterns and silicon layer patterns are formed. An epitaxial layer is grown on the side and bottom surfaces of the semiconductor substrate with the uneven structure and on the side surface of at least the pair of sacrificial layer patterns and silicon layer patterns to form a semiconductor substrate having a line-type protrusion including at least one sacrificial layer pattern. A sacrificial oxide layer is formed to fill a gap between the line-type protrusions. The resultant structure is patterned to expose the bottom surface of the substrate by using the second mask pattern having a direction crossing the first mask pattern while a semiconductor substrate having an island-type protrusion(56) including one or more sacrificial layer pattern is formed. The sacrificial layer pattern is removed to form a semiconductor substrate having an island-type protrusion with a hole(45).
Patent KR-20040078367-A (KR)
Inventor: AHN YOUNG WOOK
IPC: H05K3/00
Filed: 2003-03-04
Abstract: PURPOSE: An apparatus is provided to reduce the size of the apparatus such that the apparatus is installed in a narrow space, while achieving improved reliability and quality of soldering. CONSTITUTION: An apparatus comprises a roller housing(H) accommodating a cleaning roller(10) connected to a driving shaft(10') and an adhesive roller(11) at an idle state, wherein the roller housing is arranged to slide out by an external handle; brackets(12,12') mounted on both sides of the roller housing, and which moves up and down by hydraulic cylinders(13,13'); movable and fixed conveyor lines(16,16') having grooves(15,15'), and which drive an antistatic belt(20), wherein the movable conveyor line(16) moves along a guide rail(17); a PCB sensor(21) for sensing a printed circuit board, and which is mounted at the front end of the fixed guide rail(16'); and air nozzles(18,18') and antistatic bars(19,19') arranged at the front and rear ends of the conveyor lines.
Patent KR-20030036321-A (KR)
Title: Sound room
Inventor: AHN IK SOO
IPC: G06Q50/22
Filed: 2003-03-06
Abstract: PURPOSE: A sound room is provided to supply a high quality sound for a tired consumer at a desired time by selecting beautiful and profit sounds and storing the sounds. CONSTITUTION: A sound specialist selects beautiful and serviceable sounds for a human being. The sound specialist classifies the sounds according to subjects and themes. In addition, a novel interior adapted to a sound and comfortable environment and subject is prepared in a clean and simple room. A consumer rests from fatigue through a sound with a sound feeling. For example, a salary man improves business efficiency, and a student increases school records.
Patent KR-20040055557-A (KR)
Inventor: KIM YU JONG
IPC: H01J1/30
Filed: 2003-03-12
Abstract: PURPOSE: A field emission device and a method are provided to achieve improved stability and uniformity of electron emission from a CNT emitter by uniformly supplying a current to the emitting points of the CNT emitter. CONSTITUTION: A field emission device comprises a substrate(10); a cathode electrode(20) formed on the substrate; a gate insulating layer(30) formed on the cathode electrode, and which has a through hole(30a) corresponding to a certain part of the cathode electrode; a gate electrode(40) formed on the gate insulating layer, and which has a gate hole(40a) corresponding to the through hole of the gate insulating layer; and an electron emitter(50) formed on the cathode electrode exposed from the bottom of the through hole. The electron emitter includes a resistive material layer(51) and an electron emitting material layer(52) formed on the resistive material layer.
Patent KR-20040080791-A (KR)
Inventor: PARK YEONG SIK
IPC: H01L21/304
Filed: 2003-03-13
Abstract: PURPOSE: An automatic cleaning apparatus for wafer flat zone roller is provided to remove pollutants from a wafer flat zone roller by injecting a high-pressure gas into the wafer flat zone roller. CONSTITUTION: An automatic cleaning apparatus for wafer flat zone roller includes a roller, an injection tube, and a discharging tube. The roller(200) is operated by an operation of a driver. The injection tube(300) is used for injecting a cleaning material to the roller. The discharging tube(400) is used for absorbing the separated materials from the roller by the injected cleaning material. The cleaning material is formed with nitrogen.
Patent KR-20040083666-A (KR)
Inventor: KIM JONG HYEON
IPC: A47B63/00
Filed: 2003-03-24
Abstract: PURPOSE: Provided is an unmanned book returning system to automatically check the book as returned, in which since the processes of reading a bar code of the book and of re-producing an anti-theft label are not by hand, it is possible to save time and costs required for checking the book return. CONSTITUTION: The unmanned book returning system comprises a body with a book return opening; a pair of horizontal guides(10,10') horizontally formed on the bottom and the ceiling in the body; a vertical guide(20) formed to be back and forth movable and rotatable between the pair of horizontal guides(10,10'); an auxiliary guide(40) formed horizontally to be up and down movable to the vertical guide(20); an entrance portion(50) where a book is put in through the book return opening; a scanner(60) for reading the bar code of the book as put into the entrance portion(50); a clip portion(70) for clipping the book as put into the entrance portion(50); and a book collection case(80) for collecting the book as clipped and transferred by the clip portion(70).
Patent KR-20030081083-A (KR)
Title: 고해상도 분석용 탐침 스테이션
IPC: H01J37/20
Filed: 2003-04-08
Abstract: 본 발명은 표본상에 도전성 터미널을 노출시키는 표본의 표면을 관찰하도록 위치된 집적회로 표본상에서 주사 전자 현미경을 사용하여 전기 검사 신호를 탐침하기 위한 방법 및 시스템에 관한 것이다.  캐리어는 제어기가 주사 전자 현미경으로부터 표본의 표면을 표시하는 도전성 경로를 표시하는 영상을 획득할 동안, 주사 전자 현미경에 대해 표본을 지지하도록 제공된다.  제어기에 의해 원격제어되는 모터구동된 매니퓰레이터는 진공챔버의 내부에서 전기 검사신호를 이송 및 획득하기 위하여 표본의 표면에 위치될 수 있는 다수의 탐침을 조작하며; 상기 진공챔버는 진공에서 표본을 분석하기 위하여 주사 전자 현미경의 적어도 일부와, 캐리어와, 모터구동되는 매니퓰레이터 및 다수의 탐침을 둘러싼다. 
     진공챔버상에서의 피드스루는 제어기로부터의 전기신호를 모터구동된 매니퓰레이터 및 다수의 탐침에 연결한다.  상기 제어기는 모터구동된 매니퓰레이터와 통신하여, 다수의 탐침을 위치시키고, 주사 전자 현미경으로 관찰된 표본 표면의 도전성 경로표시부로부터 도전성 터미널을 확인하기 위하여 제어기에 의해 획득한 영상을 사용하여 표본상의 터미널에 전기신호를 인가한다.  소프트웨어에 의해, 사용자는 새로운 검사위치를 획득하고 탐침을 시작하는데 소요되는 시간을 절약하기 위하여 한 지점에서 다른 지점으로 이동할 수 있다.  이러한 동작에 의해, 탐침조립체 및/또는 하우징에 위치된 캐리어를 현미경 아래의 원하는 검사지점에 위치시킬 수 있어 현미경의 이동을 시뮬레이션할 수 있다. 
     본 발명의 시스템은 시스템의 내외로 교환될 수 있는 여러 캐리어 및 탐침을 통해 저전압 저전류 탐침을 실행을 돕고 다양한 표본이 검사될 수 있도록 다양한 형태로 형성될 수 있다.  다수의 표본에 대한 검사를 촉진시키기 위하여, 탐침 스테이션에 사용된 부품과 리드는 여러부품과 피드스루 근처에 배치된 착탈가능한 상호연결부를 포함하므로, 상기 부품들은 결선 및 연결이 최소로 된다.  탐침 스테이션의 양호한 실시예에 있어서, 탐침은 불필요한 절연기 충전량을 최소로 하기 위해 연장된 피복과, 과도한 탐침접촉으로 인해 표본의 손상위험성을 감소시키기 위해 터치다운 검출기구를 이용한다.  상기 탐침 스테이션은 고해상도 현미경의 듀티사이클을 감소시켜 현미경의 비임을 통해 DUT에 가해지는 손상을 감소시키기 위한 기구를 사용한다.
Patent KR-20040088179-A (KR)
Inventor: JUN YONG OK
IPC: H04W88/02
Filed: 2003-04-09
Abstract: PURPOSE: A method for registering greetings in a mobile communication terminal is provided to enables a user to easily register greetings by transmitting characters or voices used as the greetings to a base station through an expanded end function. CONSTITUTION: In an idle state(301), if a user presses an end key(302), a system confirms whether an expanded end function is selected(303). If so, the system confirms whether to change already-terminated data(305). If so, the system checks whether an input exists for a certain time(306). If so, the system performs a conversion process(308). If the user selects an end conversion function(305), the system carries out a greeting conversion process(308), and displays a registered list(309). If the user selects desired greetings(310), the system stores the selected greetings(311), and transmits the greetings(312).
Patent KR-20040088281-A (KR)
Inventor: LEE JEONG HWAN
IPC: B60C11/03
Filed: 2003-04-09
Abstract: PURPOSE: A radial tire tread pattern for a vehicle is provided to prevent a pattern noise of a tire and abnormal wear of a tread block by preventing a corner of a tread block from coming in contact with the ground first and inducing line contact and face contact of the ground and the tread block. CONSTITUTION: A radial tire tread pattern for a vehicle has a chamfer shape in where the depth of an upper corner of a pattern block of a tread part of a tire becomes shallower from the center of the pattern block toward the side end, to form a multiple curved surface shape. In the chamfer shape, the longitudinal or transverse curvature of the tread pattern block has each single curvature. In the chamfer shape, the depth of a chamfer of a corner in the edge direction of the tire is more than the depth of the chamfer of the corner in the center direction of the tire.
Patent KR-20040090294-A (KR)
Inventor: YOO JEONG KUN
IPC: C08K3/10
Filed: 2003-04-17
Abstract: PURPOSE: A method of using a waste denitrification catalyst as a filler for plastic articles is provided to reduce the production cost of various plastic articles in an environmentally friendly way, instead of using conventional inorganic fillers such as talc or limestone. CONSTITUTION: The method of using a waste denitrification catalyst as a filler for plastic articles comprises adjusting the particle size of the waste denitrification catalyst to the average particle size of 10 micrometers and mixing it as a filler into a composition for plastic products made of for example PP, PE and PVC.
Patent KR-20040098168-A (KR)
Inventor: BAN JAE GU
IPC: C12Q1/70
Filed: 2003-05-14
Abstract: PURPOSE: Antigenic epitope for diagnosis of Hepatitis C virus antibody is provided, which epitope reacts with the antibody more sensitively than an antigen, so that it can be useful for production of HCV infection diagnosing reagents and alive HCV vaccine. CONSTITUTION: The antigenic epitope for diagnosis of Hepatitis C virus antibody is selected from C2, C3, C5 and C7. An oligonucleotide encoding the antigenic epitope for diagnosis of Hepatitis C virus antibody is provided. A fusion protein is produced by fusion two or more of the same epitopes or two or more of the different epitopes. A cell surface expression vector contains the oligonucleotide and secretion inducing protein gene, wherein the secretion inducing protein is ice nuclei activation protein derived from Pseudomonas syringe. A transformed microorganism is produced with the cell surface expression vector. A method for expression of the antigenic epitope on the surface of a microorganism comprises culturing the transformed microorganism. A kit for detection of HCV comprises the antigenic epitope, fusion protein or the transformed microorganism.