baber/WOPTO huggingface dataset:
Patent NZ-231581-A (NZ)
Title: Cloning and expression of simian transforming growth factor-beta 1
Inventor: PURCHIO ANTHONY F
IPC: C12N15/12
Filed: 1989-11-29
Abstract: Recombinant transforming growth factor- beta 1 (TGF- beta 1) is expressed to high levels in Chinese hamster ovary (CHO) cells using dihydrofolate reductase (dhfr) gene amplification. The expression plasmid was derived from the pSV2 vectors and contained, in tandem, the simian TGF- beta 1 and mouse dhfr cDNAs. Transcription of both cDNAs was controlled by the SV40 early promoter. Stepwise selection of transfected CHO cells in increasing concentrations of methotrexate yielded cell lines expressing amplified TGF- beta 1 nucleic acid sequences. The expression plasmid DNA was amplified greater than 35-fold in one of the methotrexate selected transfectants. The major proteins secreted by these cells consisted of latent TGF- beta 1 and TGF- beta 1 precursor polypeptides as judged by immunoblots using site-specific anti-peptide antibodies derived from various regions of the TGF- beta 1 precursor. Levels of recombinant TGF- beta 1 protein secreted by these cells approached 30 ug/24 hour/10<7> cells. Expression vectors encoding TGF- beta 1 precursor variants which direct the synthesis and secretion of TGF- beta 1 in transfected mammalian cells are also described.
Patent NZ-231857-A (NZ)
Title: Furan ketone derivatives and antiretroviral compositions
Inventor: PARKER ROGER ALAN
IPC: A61P31/18
Filed: 1989-12-19
Abstract: Novel furan ketone derivatives having antiretrovirus activity and effective in a method of treatment of a retrovirus infection, have the formula <CHEM> wherein Y represents a bond, oxygen or divalent sulfur; Ar represents phenyl or naphthalenyl; n is 0 or 1; m is an integer of from 4 to 10; and R1 represents C1-6 alkyl.
Patent NZ-233375-A (NZ)
Title: Parallel system bus structure
Inventor: TAKASHIMA TOKUHEI
IPC: G06F1/18
Filed: 1990-04-19
Abstract: Disclosed is an improved parallel system bus structure comprising a plurality of bus wire-printed disks (5) each having a plurality of signal conductors (6) of equal length extending radially from a common central contact (7). These bus disks (5) are spaced vertically at regular intervals, and a plurality of connectors (12) are fixed to the circumference of the bus disks to permit connection between the signal conductors of the bus disks and the terminals of the CPU board. The radial arrangement of signal conductors (6) permits connection of selected CPU boards via equal length signal paths, no matter how many CPU boards may be used.
Patent NZ-233538-A (NZ)
Title: Multi-bus microcomputer with programmable control of lock function
Inventor: BEGUN RALPH M
IPC: G06F12/08
Filed: 1990-05-02
Abstract: A dual bus microcomputer system including a cache subsystem improves performance under certain circumstances by allowing programmable control over the LOCK function. More particularly, additional logic is coupled between the LOCK output of the CPU and the LOCK input of the cache controller. A control bit from an I/O port is a second input to the additional logic. With the control bit in one state, the logic allows the LOCK input to follow the LOCK output. In the other state of the control bit, the LOCK input is disabled regardless of the state of the LOCK output.
Patent NZ-238986-A (NZ)
Title: Fliud-tight pipe coupling with slots in sealing sleeve that receive teeth of gripping ring
Inventor: WEBB IAN RICHARD
IPC: F16L21/00
Filed: 1991-07-16
Abstract: PCT No. PCT/GB91/01232 Sec. 371 Date Jan. 26, 1993 Sec. 102(e) Date Jan. 26, 1993 PCT Filed Jul. 23, 1991 PCT Pub. No. WO92/02752 PCT Pub. Date Feb. 20, 1992.A pipe coupling for connecting together two plain-ended pipes in a fluid-tight manner comprises an outer tubular casing, an inner tubular casing and a tubular sealing sleeve. The sealing sleeve has two sets of inwardly projecting ribs which, in use, are pressed into sealing engagement with the respective ends of the pipes. The inner and outer casings are longitudinally split and tensioning screws on the outer casing can be tightened to tighten the outer casing around the inner casing and the sealing sleeve. Frustoconical slots in the outer surfaces of the sealing sleeves receive frustoconical gripping rings which have gripping teeth on the inner sides which bite into the pipe surfaces to secure the pipes against axial displacement.
Patent NZ-247307-A (NZ)
Title: Use of doxazosin and hydroxylated metabolites and derivatives thereof for preparation of anti-atherosclerosis agents
Inventor: WONG SAMUEL S
IPC: A61K31/495
Filed: 1993-03-31
Abstract: This invention relates to the use of certain hydroxylated metabolites and derivatives of doxazosin and their pharmaceutically acceptable acid addition salts for retarding the development of atherosclerosis in a mammal. Such compounds are useful for reducing atherosclerotic plaque involvement and for retarding and reducing both lipid deposition fibrosis in the development of atherosclerotic plaques.
Patent NZ-260018-A (NZ)
Title: Benzimidazole compositions and anthelmintic compositions
Inventor: MCLAREN DONALD GEORGE
IPC: A61K9/00
Filed: 1994-03-03
Abstract: PCT No. PCT/NZ95/00023 Sec. 371 Date Sep. 27, 1996 Sec. 102(e) Date Sep. 27, 1996 PCT Filed Mar. 2, 1995 PCT Pub. No. WO95/23590 PCT Pub. Date Sep. 8, 1995A pour-on anthelmintic composition, including its method of preparation and use, the composition preferably having being prepared by mixing at a common temperature (I) a premix of an anthelmintic compound or compounds (for example a benzimidazole) with a transdermal vehicle (such as isopropyl myristate) with (ii) a premix of a non-ionic emulsifier with an oil capable of solubilising the emulsifier and, subsequent to the blending of the premixes (preferably after cooling), mixing the blend with a deflocculation agent/diluent or deflocculation agent/diluent mix.
Patent NZ-267192-A (NZ)
Title: Production of omega-aminoalkyl guanidine derivatives and products and precursors
Inventor: NYSTROM JAN-ERIK
IPC: C07D231/12
Filed: 1994-06-01
Abstract: PCT No. PCT/SE94/00517 Sec. 371 Date Jun. 28, 1994 Sec. 102(e) Date Jun. 28, 1994 PCT Filed Jun. 1, 1994 PCT Pub. No. WO94/29269 PCT Pub. Date Dec. 22, 1994A process for the production of guanidino protected  omega -aminoalkyl guanidines comprising reacting a diamine selectively at one amino group with an alkoxycarbonyl or aralkoxycarbonyl protected electrophilic guanylation reagent. The process of the invention is general and may be performed efficiently in one step yielding a product with high purity and in useful yields. The invention further refers to some compounds that are novel per se and to some novel compounds useful in the process of the invention.
Patent NZ-284696-A (NZ)
Title: Process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives
Inventor: WOLF RICHARD A
IPC: C07B61/00
Filed: 1995-04-18
Abstract: The present invention relates to a novel process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones which are useful for the treatment of Alzheimer's disease and senile dementia as disclosed by Schirlin, et al. in European Patent Application Publication No. 0 409 676, published Jan. 23, 1991.
Patent NZ-287863-A (NZ)
Title: Synergistic fungicidal mixtures containing an oxime ether carboxylic ester and a 1-(2-cyano-2-methoxyiminiacetyl)-3-ethylurea
Inventor: AMMERMANN EBERHARD
IPC: A01N47/34
Filed: 1995-05-27
Abstract: fungicidal mixture for controlling harmful fungi. Described are fungicidal mixtures containing: a) an oxime ether carboxylic acid ester of formula (Ia) or (Ib) and b) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (H3CCH2-NHCONH-C(CN)=NOCH3) in a synergistically effective amount.
Patent NZ-293687-A (NZ)
Title: Alk-7 (activin-like kinase) which is a serine threonine kinase receptor
Inventor: RYDEN MIKAEL
IPC: G01N33/577
Filed: 1995-10-20
Abstract: The present invention relates, in general, to a novel serine threonine kinase receptor, ALK-7. In particular, the present invention relates to nucleic acid molecules coding for ALK-7; ALK-7 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to ALK-7; hybridomas containing the antibodies; nucleic acid probes for the detection of ALK-7 nucleic acid; a method of detecting ALK-7 nucleic acid or polypeptide in a sample; and kits containing nucleic acid probes or antibodies. This invention further relates to bioassays using the nucleic acid sequence, receptor protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with neurodegenerative disease. Therapeutic uses for ALK-7 are also provided. This invention also relates to ligands, agonists, and antagonists of the ALK-7 receptor, and diagnostic and therapeutic uses thereof.
Patent NZ-311722-A (NZ)
Title: Device for positioning a machining spindle using the pilot rod thereof
Inventor: GERARD DANIEL
IPC: B23Q1/38
Filed: 1996-06-12
Abstract: Means for aligning the device include a ball holder (17) placed on a base (4) in such a way that it is movable in all directions in a horizontal plane during the positioning phase of the spindle (6), a spherical ball (13) freely rotatably mounted in the ball holder (17), and a substantially vertical quill (10) that is axially movable within the ball (13) and supports the tool driving spindle. Said spherical ball (13) has weights that balance the weight of the means for translating the quill (10) and that of said quill and said spindle when the latter are in the lower aligned position, so that said weights return the centre of gravity (G) of the assembly substantially into alignment with the axis (x, x') of the quill (10), whereas the electrical means (28, 29) for driving the spindle (6) are arranged in the quill (10) and thus locate the centre of gravity thereof on said axis (x', x) and close to the centre (C) of the spherical ball (13) when said quill is in the lower aligned position. Furthermore, means for generating a planar air cushion between the base (4) and the ball holder (17) include jets (47) arranged in the base (4) opposite the ball holder (17) for feeding a film having a uniform thickness, and clamping means include nozzles (62) separate from the cushion-forming jets (47) and capable of being connected to a vacuum source.
Patent NZ-314488-A (NZ)
Title: Anticancer medicaments containing alpha1-adrenoreceptor antagonist compounds
Inventor: THOMPSON TIMOTHY C
IPC: A61K31/00
Filed: 1997-03-26
Abstract: The specification describes a method for treating or preventing a cancer which comprises administering an amount of a drug comprising a specific a1-adrenoreceptor antagonist, doxazosin, or its 6'-hydroxy or 7'-hydroxy metabolites.
Patent NZ-323403-A (NZ)
Title: Multilayer sealing film and container sealing assembly
Inventor: ENGELAERE JEAN-CLAUDE
IPC: B65D77/20
Filed: 1996-11-28
Abstract: The  specification describes a sealing structure (S) for a container (C) with an opening (O).   The opening has a sheet (F) welded around the edge of the container and consists of at least three layers, i.e. a weld layer (1) applied and welded to the edge of the opening along a bead (4), an outer barrier layer (2) and an intermediate adhesive layer (3). The weld between the bead (4) of the weld layer (1) and the edge of the opening has a tear resistance higher than the adhesive force between the weld layer (1) and the adhesive layer (3), whereby after the opening (O) has been unsealed for the first time, the weld bead (4) remains in place along the edge thereof and is separated from the weld layer (1) and the adhesive layer (3), which is thus exposed in an area (7).  This  enables the container (C) to be resealed by reapplying the adhesive layer onto the bead (4).
Patent NZ-331613-A (NZ)
Title: Piperazinyl or piperidinyl substituted 1,2,3,4-tetrahydronaphthalene derivatives
Inventor: BERG STEFAN
IPC: A61P43/00
Filed: 1997-03-20
Abstract: Piperidinyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives are of  the formula shown wherein X is N or CH; Y is NR2CH2, CH2-NR2, NR2-CO, CO-NR2 or NR2SO2; R1 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, where aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted; n is 0-4; and including (R)-enantiomers, (S)-enantiomers and racemates in the form of the free bases and pharmaceutically acceptable salts and hydrates thereof.  They are said to be useful in the treatment of 5-hydroxytryptamine mediated disorders.  Also included are some intermediate compounds where -YR3 is NH2 or COOH.
Patent NZ-333331-A (NZ)
Title: System for the pneumatic delivery of emulsion explosives from a pressurized vessel
Inventor: MCDONALD KEITH J
IPC: F42D1/10
Filed: 1997-06-16
Abstract: The application provides a system for the pneumatic extrusion of an emulsion explosive into a borehole.  This system comprises a pressurized vessel for holding the emulsion explosive under pressure (2), a pressurized water source (1) (preferably a vessel for holding water under pressure), an outlet from the emulsion vessel (10), a water injector connecting the outlet to a delivery hose (14) and a conduit (such as a hydraulic hose) for providing the pressurized water to the water injector (9).
Patent NZ-335383-A (NZ)
Title: Epothilone C,D,E and F for plant protection and cytostatic effects shown in kidney cells
Inventor: REICHENBACH HANS
IPC: C12P1/04
Filed: 1997-11-18
Abstract: Epothilone derivatives C (R = hydrogen) and epothilone D (R = methyl) of formula (I), as well as epothilone E (R = hydrogen) and epothilone F (R = methyl) of formula (II), the production process and their application for producing therapeutic agents, including cytostatic agents, as well as phytosanitary agents.
Patent NZ-337593-A (NZ)
Title: Superconductor inserted into metal tube coated with metal oxide suspension prior to coiling and heating
Inventor: HAN ZHENGHE
IPC: H01L39/24
Filed: 1998-03-25
Abstract: A superconducting wire is formed by inserting a superconducting base material into a metal tube.  The tube is then coiled so that one part of the tube outer surface contacts another part of the tube's outer surface. The tube is then heated to a temperature close to the melting point of the metal tube to form the superconducting material.  Before coiling, the tube is coated with a liquid containing a suspension of metal oxide particles.  The liquid burns or evaporates completely when the tube is heated, the particles having a melting point higher than that of the metal tube.
Patent NZ-337813-A (NZ)
Title: Mononuclear phagocytes and their use to promote axonal regeneration
Inventor: EISENBACH-SCHWARTS MICHAL
IPC: A61K35/14
Filed: 1998-03-13
Abstract: Methods and compositions are disclosed for the use of allogeneic mononuclear phagocytes to promote axonal regeneration in the central nervous system of a mammal. In one embodiment, allogeneic mononuclear phagocytes are administered into the CNS at or near a site of injury or disease and the mammal is treated with at least one anti-inflammatory agent. In another embodiment, allogeneic mononuclear phagocytes are administered into the CNS at or near a site of injury or disease and one or more enumerated adjuvant factors (e.g. aFGF) are administered to the CNS; anti-inflammatory therapy of the mammal may optionally be added. In a further embodiment, allogeneic mononuclear phagocytes are first stimulated with one or more enumerated stimulatory factors and then administered into the CNS at or near a site of injury or disease. Methods for screening stimulatory tissue and cells are also disclosed.
Patent NZ-501101-A (NZ)
Title: Modulation detection method and apparatus
Inventor: HUTTUNEN MIKKO
IPC: H04L25/03
Filed: 1999-03-22
Abstract: A modulation detection method and apparatus, comprising taking a sample from a received signal, determining reference constellation points, calculating path-specific error metrics from a sample point to the reference constellation points, and applying the path-specific error metrics corresponding to the reference constellation points to a modulation detector (14). Out of the reference constellation points the constellation points, preferably two of them, having the smallest error metrics are selected, and only the error metrics corresponding thereto are applied to the modulation detector (14).
Patent NZ-502429-A (NZ)
Title: Waste water treatment system tanks interlocked together by a relative sliding movement
Inventor: MOON NEVILLE ROBERT
IPC: C02F1/00
Filed: 2000-01-20
Abstract: A wastewater treatment system (100) comprising two or more tanks, joined by a slidingly engaged male/female connection means (20). Each tank has a male (21) and/or a female connection (22) integrally formed in the tank, wherein engagement of the connection is by a relative sliding movement generally parallel to the axis of the tank.
Patent NZ-505161-A (NZ)
Title: Synthetic linear amino acid constructs which support epitopes of antigens
Inventor: SCHWABE CHRISTIAN
IPC: C07K16/00
Filed: 1998-11-13
Abstract: Described are synthetic constructs comprising a linear core chain having two or more side chains pending directly from different points on the linear core chain.  Each of the side chains comprises an epitopic site of an antigen or a peptide.  The synthetic constructs are monomeric units that can be linked together or polymerised to form a polymer.  In this feature the epitopic sites of the side chains may be the same or different.  The linear core chain may be a linear sequence of amino acids having two or more of the same peptide pending directly from different points on the linear sequence.  Another aspect concerns a support having one or more of the aforementioned synthetic constructs or polymers coupled thereto.  Another embodiment is directed to antibodies raised against the synthetic constructs or polymers.  The antibodies can be purified using the aforementioned supports.  Also described is a vaccine comprising the aforementioned synthetic constructs.  Methods for synthesizing the constructs and polymers are also included. In Fig.1, a monomer (100) is depicted having a linear core chain (102) with side chains (104) pending therefrom.  Functional group X and functional group Y are related in that they are capable of reacting with one another to form a covalent bond and thereby link two or more monomers to form a polymer (120) as depicted in Fig. 2. The functional groups may be selected from those described above, e.g., in conjunction with the definition of a monomer.  The monomers may be the same or different.  When the monomers are different, the differences can reside in the composition of linear core chain (102) or side chains (104), or both.
Patent NZ-505539-A (NZ)
Title: A method for wood drying using x-rays to determine moisture content to enable sorting
Inventor: MILLER WAYNE ROBERT
IPC: G01N23/02
Filed: 2000-07-03
Abstract: A method for drying pieces of wood including the steps of; determining an x-ray transmission rate for each of the wood pieces, assigning each of the wood pieces a predicted speed of drying grading based on one of more factors including an x-ray transmission rate or attenuation and drying some pieces assigned a predicted faster speed of drying under different drying conditions from some pieces assigned a predicted slower speed of drying.
Patent NZ-506253-A (NZ)
Title: A staple inorganic fiber having a chemical sizing, having a very high surfactant level on its surface for a fiberglass reinforced gypsum board
Inventor: SMITH HENRY DALL
IPC: C03C25/24
Filed: 2000-08-10
Abstract: A method of making a fiber reinforced product in a process comprising selecting a glass fiber product containing a chemical sizing with the surfactant level on the fiber in an amount in the range of 0.08-0.24 wt. percent, based on the weight of dried fiber, wherein the sizing contains 30-60 wt. percent, on a dry basis, of a cationic surfactant and 20-50 wt. percent of the LOI (loss of ignition) on the same basis of a polymer film former (such as polyvinyl alcohol), dispersing fiber in plant water; forming a fiber reinforced product. The reinforced product may further comprise a biocide to retard microbial action.
Patent NZ-510943-A (NZ)
Title: Delivery system for porcine somatotropin
Inventor: KEEGAN MITCHELL
IPC: C12N15/85
Filed: 1999-10-18
Abstract: An expression construct useful for delivering an exogenous polypeptide (e.g. a growth hormone such as somatotropin) to a host. In one application, the expression construct is introduced into a non-host recombinant cell encapsulated in a semi-permeable membrane for implantation into the host. The semi-permeable membrane inhibits immune surveillance and cell rejection events so that non-host, highly expressing, recombinant cells can be used. A method for delivering exogenous peptides using the expression construct is also disclosed.
Patent NZ-512714-A (NZ)
Title: Amidinobenzylamine derivatives useful as thrombin inhibitors
Inventor: NYSTROM JAN-ERIK
IPC: A61K38/55
Filed: 2000-01-13
Abstract: An amidinobenzylamine derivative or a pharmaceutically acceptable salt thereof has the formula (I) wherein: R1 is N(R5)R6 or S(O)mR7; R2 and R3 independently are halo or optionally halo substituted alkyl or alkoxy; Y is optionally substituted alkylene; R4 is H, OH, OR8a, C(O)OR8b or R8c; R5 is optionally halo substituted alkyl and R6 is optionally halo substituted alkyl, C(O)R9 or together with R6 and the nitrogen atom to which they are attached, form a 3- to 7- membered nitrogen containing ring optionally including an oxygen atom and/or optionally substituted by a =O group or N(R5)R6 can form an optionally substituted pyrrole or imidazole; m is 0, 1 or 2; R7 is H, NH2 or alkyl; R8a and R8b independently are alkyl, alkylphenyl or aryl, or R8a is C(R10a)(R10b)OC(O)R11, C(R10a)(R10b)N(H)C(O)OR12 or C(R10a)(R10b)OC(O)N(H)R12, R8c is C(R10a)(R10b)OC(O)R11, C(R10a)(R10b)N(H)C(O)OR12 or C(R10a)(R10b)OC(O)N(H)R12, R9 is alkyl, Het1, aryl or alkyl substituted by aryl and Het1, R10a, R10b, R11, and R12 are as defined in the specification provided that:(a) when m is 1 or 2, then R7 is not H; and (b) when m is 0, then R7 is not NH2. The compounds are useful in treating thrombosis or hypercoagulability in blood and tissues.
Patent NZ-513111-A (NZ)
Title: Agent for treating visual cell function disorder
Inventor: UENO RYUJI
IPC: A61K31/407
Filed: 1999-12-20
Abstract: The present invention provides the use of a compound of formula I in the manufacture of a medicament for treating retinopathy and visual cell function disorder confirmed by ERG, wherein R1 to R24 are as defined in the specification.
Patent NZ-516744-A (NZ)
Title: Highly purified cytokine activating factor and methods of use
Inventor: IYER SUBRAMANIAN
IPC: A61K38/00
Filed: 2000-07-19
Abstract: A cytokine actuating factor (CAF) protein comprising the: (a) amino acid sequence selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:6; and (b) amino acid sequence comprising at least 9 consecutive amino acid residues of an amino acid sequence of (a); wherein said isolated protein upregulates expression of tumor necrosis factor Alpha (TNFAlfa), interleukin-1Beta (IL-1Beta) or interleukin-6 (IL-6), or downregulates expression of transforming growth factor Beta (TGFBeta); and the use thereof to regulate immune response.
Patent NZ-517199-A (NZ)
Title: In vitro repair of bone and cartilage defects
Inventor: OSTHER KURT
IPC: A61K35/12
Filed: 2000-07-25
Abstract: A cartilage or interface membrane carrying a composition comprising at least one stimulation molecule which induces signal transduction in chondroblasts/chondrocytes and/or osteoblasts/osteocytes and is selected from the group consisting of collagen proteins such as collagen types I, VI, IX, and XI, proteoglycans such as aggregans, decorin, fibromodulin and biglycan, or a non-collagenous proteins such as cryoprecipitate, fibronectin, vitronectin, fibronogen, fibrillin, kistrin, echistatin, von Willebrand factor, tenascin and anchorin CII.