Patent SG-11201810109U-A (SG)
Title: Treatment of alphavirus-induced inflammation
Inventor: MAHALINGAM SURENDRAN
IPC: A61K31/737
Filed: 2016-05-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111011101111011111 111111111100111111111 1111111110B11110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/201563 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) (21) (22) (25) Filing Language: (26) (71) (72) (74) (81) International Patent Classification: A61K 31/737 (2006.01) A61P 31/12 (2006.01) A61P 29/00 (2006.01) A61P 19/02 (2006.01) International Application Number: PCT/AU2016/050408 International Filing Date: 26 May 2016 (26.05.2016) Publication Language: MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, English TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 170 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: Lara — with international search report (Art. 21(3)) 4215 New every AM, BY, BZ, DO, DZ, HR, KZ, LA, MN, Applicant: GRIFFITH UNIVERSITY [AU/AU]; Kessels Road, Nathan, Queensland 4111 (AU). Inventors: MAHALINGAM, Surendran; 45 Maltravers Drive, Arundel, Queensland 4214 (AU). HERRERO, Josefina; 70 Deakin Avenue, Southport, Queensland (AU). Agent: FB RICE; Level 23, 44 Market Street, Sydney, South Wales 2000 (AU). Designated States (unless otherwise indicated, for kind of national protection available): AE, AG, AL, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, = = _ = = (54) Title: TREATMENT OF A 8 la 1 404 : Disclosed is a to an infected subject. Whilst not effecting the viral load in a subject, the pentosan polysulfate acts to reduce inflammation in such as the muscles, inflammation and/or cartilage as Ross River virus, chikungunya virus and Barmah Forest virus. istered such ALPHAVIRUS-INDUCED INFLAMMATION ti. o, g 6 g. 0 Figure 3 Quadriceps Jed *Iwo s -n- PaStreated -::- Llock4reoto = = = = _ = _ = = = — = 4 0 it 4tl iY Edam mat Infection llaV :dna k,adt Sore lad 1 s a ft a6 0 4 8 18 0,0 04 reat intstann Dam past infeetion Rae/ vas! load Odpi etRV real Wort 3 teethe \"a 101 s 9th 0 ale iirei Of . — = — ll en kr) Il 0 el (57) .- 1-1 tissues, © in ei 14o2I . 9 le' 0..p --o\" lc Itretreend field ftIttltnPfi effV.Peri method of treating alphavirus infections, particularly in humans, in which pentosan polysulfate is admin- and in the joints of a subject. In addition, cartilage damage in the joints may be reduced. The reduction damage acts to reduce the severe pain experienced by subjects suffering from alphavirus infections,