baber/WOPTO huggingface dataset:
Patent CA-3156298-A1 (CA)
Title: Combinaison d'un antagoniste de cxcr7 avec un modulateur du recepteur s1p1
Inventor: POUZOL LAETITIA
IPC: A61P19/02
Filed: 2020-10-30
Abstract: La présente invention concerne le composé (3S,4S)-1-cyclopropylméthyl-4-{[5-(2,4-difluoro-phényl)-isoxazole-3-carbonyl]-amino}-pipéridine-3-acide carboxylique (1-pyrimidin-2-yl-cyclopropyl)-amide. (Formule) et son utilisation en tant que modulateur du récepteur CXCR7 de CXCL11/CXCL12, en particulier en combinaison avec d'autres principes actifs ou agents thérapeutiques comprenant un modulateur du récepteur 1 de la sphingosine-1-phosphate (S1P1)) dans la prévention ou le traitement de maladies et de troubles dans lesquels à la fois l'expression de CXCR7 ou ses ligands et S1P jouent un rôle. L'invention concerne en outre des compositions pharmaceutiques comprenant le composé en combinaison avec lesdits autres principes actifs ou agents thérapeutiques.
Patent CA-3158281-A1 (CA)
Title: Compositions et methodes de traitement de troubles du stockage du glycogene
Inventor: GRAY JOHN T
IPC: A61K48/00
Filed: 2020-10-23
Abstract: La présente invention concerne des compositions et des procédés utiles pour traiter des troubles du stockage du glycogène, tels que le trouble du stockage du glycogène de type II, également appelé maladie de Pompe. En utilisant les compositions et les procédés de l'invention, un patient (par exemple, un patient mammifère, tel qu'un patient humain) atteint de la maladie de Pompe peut se voir administrer un vecteur viral, tel qu'un vecteur viral adéno-associé (AAV), qui contient un transgène codant pour l'alpha-glucosidase acide.
Patent CA-3159193-A1 (CA)
Inventor: DE LOMBAERT STEPHANE
IPC: C07D498/04
Filed: 2020-10-30
Abstract: Cette invention concerne des procédés de préparation d'un modulateur du récepteur S1P " composé 1", qui est utile dans le traitement de maladies ou de troubles associés à l'activité de S1P, notamment des troubles du SNC. Le procédé comprend la réaction du "composé 2" avec le "composé 3" en présence d'un agent réducteur.
Patent CA-3162633-A1 (CA)
Title: Combination therapies for treating cancer
Inventor: WAN HONG
IPC: A61K33/243
Filed: 2020-11-25
Abstract: Provided are methods of treating cancer that comprise administering a polypeptide (e.g. a fusion polypeptide) that comprises a SIRPa D1 domain variant and an Fe domain variant in combination with at least one chemotherapy agent and/or at least one therapeutic antibody. Also provided are related kits.
Patent CA-3162871-A1 (CA)
Title: Filter for preparing coffee or infusion
Inventor: ROMBOUTS XAVIER
IPC: B65D85/804
Filed: 2020-04-29
Abstract: Filter (1) for preparing coffee or an infusion for single use, of the type that comprises a tub (6) for pouring a liquid over, usually water, and whereby, when considered in use position, a compartment (4) is provided at the bottom of the tub (6) which is partly delimited by means of water- permeable layers and in which coffee or herbs are provided, whereby the tub (6) is made of an essentially cylindrical or conical jacket (6'), the lower edge of which is provided with an inwardly oriented supporting edge (5) which transitions into a cylindrical compartment (4) with perforated base, whereby the inwardly oriented supporting edge (5) serves as a supporting edge for the filter (1) when said filter is placed on a cup (11), characterised in that at least the outside surface of the supporting edge on the outside is provided with a microroughness Ra between 10 and 200 ?m
Patent CA-3163008-A1 (CA)
Inventor: FULLER JAMES
IPC: A23J3/20
Filed: 2021-03-25
Abstract: The present invention relates to mushroom-based meat substitutes and methods of producing mushroom-based meat substitutes, wherein the method incorporates a retorting step. The invention has been developed to provide versatile vegetarian or vegan alternatives to meat that can mimic the visual, textural, and/or flavour characteristics of meat, and in particular, cooked meat products.
Patent CA-3169443-A1 (CA)
Title: Recreational vehicles with heated steering components
Inventor: NORSTAD TIMOTHY P
IPC: B62D1/06
Filed: 2022-07-28
Abstract: A system for communicating with components on a steering member has a first electrically conductive coil affixed to a stationary component around a steering shaft of the vehicle. A second electrically conductive coil is coupled to and rotating with the steering member. The second transceiver is wirelessly operatively coupled the first transceiver. The first transceiver coupled to the first electrically conductive coil. A  second transceiver is coupled to the second electrically conductive coil. The first electrically conductive coil induces current in the second electrically conductive coil to power a first component of the components. The first electrically conductive coil is spaced apart from the second electrically conductive coil. The first transceiver and the second transceiver bi-directionally wirelessly communicate through the first electrically conductive    coil    and    the    second    electrically conductive    coil.
Patent CA-3172325-A1 (CA)
Title: Wound dressing control and activation
Inventor: ASPIOTI MARIA
IPC: A61L15/18
Filed: 2021-04-01
Abstract: Disclosed embodiments relate to a wound dressing which can generate nitric oxide. The wound dressing may include a cover layer, an activator layer such as an acid providing layer and nitric oxide source layer, such as a nitrite providing layer. The activator layer may include acidic groups and may be hydrogel, xerogel, or other suitable material. The nitric oxide source layer may include a nitrite salt. Nitrite ions of the nitric oxide source layer may react with the acidic groups of the activating layer to generate nitric oxide. The activating layer may include a window at the center, and a central absorbent material may be positioned at the window. Various separating layers may also be incorporated into the dressing to control the interaction between activating layer and nitric oxide source layer.
Patent CA-3174991-A1 (CA)
Inventor: BRADLEY RYAN
IPC: E21B43/116
Filed: 2020-12-11
Abstract: A method and apparatus for containing one or more shaped charges in a single plane, arrayed about the center axis of a gun body, and detonated from a single initiator in a shaped charge cluster assembly.
Patent CA-3175144-A1 (CA)
Title: Ccr7 antibody drug conjugates for treating cancer
Inventor: ASKOXYLAKIS VASILEIOS
IPC: A61P35/00
Filed: 2021-04-28
Abstract: This application discloses compositions and methods of treating follicular lymphoma using CCR7 antibody drug conjugates. Also disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to said subject an antibody drug conjugate, wherein the cancer expresses CCR7, wherein the antibody drug conjugate is administered to said subject at about 0.1 mg/kg to about 10 mg/kg.
Patent CA-3176312-A1 (CA)
Inventor: RANA JATINDER
IPC: A23L33/11
Filed: 2021-04-12
Abstract: Compositions for and methods of maintaining bone structure, cartilage structure or both, minimizing hone reabsorption, preventing cartilage degradation, increasing bone density, promoting healthy joints by protecting cartilage integrity, diminishing the action of enzymes that affect bone health, cartilage health, or both, improving joint movement or function, alleviating joint pain, alleviating joint discomfort, alleviating joint pain and discomfort, alleviating joint stiffness, improving joint range of motion or flexibility, promote mobility, or the like, wherein the composition comprises a therapeutically effective amount of a botanical extract of the testa of Anacardium occidentale L, wherein the botanical extract is enriched for total catechin content,
Patent CA-3178623-A1 (CA)
Inventor: CHU BOBY
IPC: A61B1/018
Filed: 2021-05-12
Abstract: An attachment system for detachably attaching an additional channel to an endoscope, the attachment system comprising: a sleeve for receiving a distal end of the endoscope and a distal end of the additional channel in use, the sleeve having: a sleeve body defining a sleeve channel, through which the distal end of the endoscope and the distal end of the additional channel will extend in use, and having a first open end and a second open end; a rupture mechanism for rupturing the sleeve body to allow separation of the distal end of the additional channel from the distal end of the endoscope.
Patent CA-3178641-A1 (CA)
Inventor: THABIT ALI
IPC: B23B29/04
Filed: 2021-05-27
Abstract: Un adaptateur d'outil (20) présente un axe d'adaptateur (AA) définissant une direction d'avant en arrière de l'adaptateur (DF, DR), et comprend : une partie de retenue avant (22) ayant une mâchoire de base (26), une mâchoire de serrage (28), et une poche de réception d'insert (30) située entre elles, la poche de réception d'insert (30) ayant une surface de support inférieure (32) et une surface de serrage supérieure opposée (34), et une partie de montage arrière (24) située axialement à l'arrière de la partie de retenue avant (22), la partie de montage arrière (24) ayant une surface de montage arrière orientée axialement vers l'arrière (50) et un premier trou de fixation (54). Une fente primaire (42) sépare la mâchoire de base (26) de la mâchoire de serrage (28) et communique avec la poche de réception d'insert (30) ; une fente secondaire (52) transversale à la fente primaire (42) sépare la mâchoire de serrage (28) de la partie de montage arrière (24) ; et le premier trou de fixation (54) présente un premier axe de trou (Al) qui coupe la surface de montage arrière (50) et la fente secondaire (52).
Patent CA-3182099-A1 (CA)
Title: Systemes de generation d'energie solaire en trois dimensions et procedes de deploiement
Inventor: LEBIODA KENNETH EUGENE
IPC: H02S20/10
Filed: 2021-06-15
Abstract: L'invention concerne des systèmes de génération d'énergie solaire en trois dimensions. Les systèmes sont caractérisés par une pluralité de panneaux solaires configurés pour comprendre des panneaux de face polaire et équateur et, dans divers modes de réalisation, des panneaux supérieurs et/ou latéraux supplémentaires qui forment un ensemble segmenté et en forme de dôme. Les systèmes présentent des rendements améliorés en particulier en ce qui concerne la génération d'énergie tôt le matin et le soir qui permettent d'obtenir des densités de puissance améliorées sur une zone terrestre donnée par rapport aux réseaux de panneaux solaires classiques. La présente invention concerne également des procédés de déploiement des systèmes.
Patent CA-3182728-A1 (CA)
Title: Composition cosmetique pour ameliorer l'aspect de la peau
Inventor: KULKARNI ADITI JAYAVANT
IPC: A61K8/37
Filed: 2021-06-10
Abstract: L'invention concerne une composition cosmétique comprenant : i) de l'octénylsuccinate d'amidon d'aluminium ; et, ii) un ingrédient ayant le nom INCI octénylsuccinate d'amidon d'aluminium (et) copolymère d'acrylate (et) carbonate de magnésium.
Patent CA-3182912-A1 (CA)
Title: Htt modulators for treating huntington's disease
Inventor: DOMINGUEZ CELIA
IPC: A61K31/506
Filed: 2021-05-12
Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
Patent CA-3183827-A1 (CA)
Inventor: CARLESSO FRANCO
IPC: C21B3/08
Filed: 2021-06-23
Abstract: Procédé de traitement de matériau (1) formé/situé au fond d'un four-poche (12), ledit matériau comprenant des scories blanches contenant de la chaux ou des composés à base de chaux et comprenant également un alliage métallique, de préférence de l'acier, à l'état fondu ou semi-fondu/visqueux, caractérisé en ce que ledit matériau (1) à la sortie dudit four-poche (12) refroidit pendant une durée inférieure à environ 30 à 45 minutes, de préférence pendant moins de 10 à 15 minutes, et encore plus préférentiellement pendant moins de 1 à 3 minutes.
Patent CA-3184944-A1 (CA)
Inventor: SCHNEIDER MARC
IPC: F04D29/38
Filed: 2021-03-04
Abstract: The invention relates to a fan blade (1) having a front inflow edge (2) and a rear outflow edge (3), wherein the fan blade (1) has an at least partially wavy inflow edge (4), wherein this forms a wave (W) having a specific three-dimensional waveform.
Patent CA-3186171-A1 (CA)
Inventor: LEHNER SAMUEL
IPC: G01S13/38
Filed: 2020-07-17
Abstract: L'invention concerne un procédé et un dispositif de sondage d'une structure souterraine. Le procédé comprend les étapes consistant à : envoyer une onde électromagnétique dans la structure, recevoir un écho de l'onde électromagnétique provenant de la structure et traiter l'écho pour dériver une caractéristique interne de la structure. L'étape d'envoi de l'onde électromagnétique dans la structure comprend ensuite l'envoi d'une pluralité de signaux de sonde électromagnétique ayant des spectres de fréquence différents dans la structure. Chaque signal de sonde comprend au moins deux composantes spectrales non nulles. L'étape de réception de l'écho comprend la réception d'un signal d'écho pour chaque signal de sonde. L'étape de traitement de l'écho comprend la détermination d'au moins une amplitude et une phase pour chaque signal d'écho.
Patent CA-3186771-A1 (CA)
Inventor: ANDREWS MARK
IPC: A61P17/06
Filed: 2021-06-10
Abstract: La présente invention concerne un composé selon la formule (I), (I) et des sels, hydrates ou solvates pharmaceutiquement acceptables de celui-ci. L'invention concerne en outre lesdits composés destinés à être utilisés en thérapie, des compositions pharmaceutiques comprenant lesdits composés, des procédés de traitement de maladies, par ex., des maladies dermiques, avec lesdits composés, et l'utilisation desdits composés dans la fabrication de médicaments.
Patent CA-3187331-A1 (CA)
Title: Process for manufacturing a structural component in composite material stiffened with at least one stringer
Inventor: CORVAGLIA STEFANO GIUSEPPE
IPC: B64C1/06
Filed: 2021-07-27
Abstract: Process for manufacturing a structural component (1, 1', 1", 1''', 1"" ) made of composite material comprising a skin (2) and at least one stiffening stringer (3, 3', 3", 3"', 3"") applied rigidly and integrally to one face (2a) of the skin (2); the process comprises the following steps: a) arranging on a tool (12, 12', 12", 12''', 12"") a plurality of first layers (4; 4a', 4b'; 4"; 4'"'; 4a"", 4b"", 4c"") of uncured or p re-cured composite material forming the stringer (3, 3', 3", 3'", 3"") presenting a longitudinal axis (A) and having a raised portion (7, 7', 7", 7''', 7"" ) protruding from at least one flange (8) extending parallel to the longitudinal axis (A) and along a lying surface that is flat or is a surface of revolution (S);) b) arranging on said tool (12, 12', 12", 12''', 12"") a plurality of second layers of uncured or p re-cured composite material forming said skin (2); c) making a face (2a) of said skin (2), parallel to said lying surface (S), and said flange (8) of said stringer (3, 3', 3", 3'", 3"") adhere to each other; d) applying predetermined temperature and pressure on the assembly thus formed so as to compact said layers together, possibly curing the uncured material and rigidly joining said skin (2) to said stringer (3, 3', 3", 3'", 3"" ); and e) performing a cutting operation on the free end side edge/s (13) of said flange (8) in a transversal direction with respect to said lying surface (S); and f) cover said end side edge/s (13) of the end of said flange (8) with a coating of composite material so as to seal outwards the layers (4; 4a', 4b'; 4 "; 4'"; 4a"", 4b"") forming said flange (8).
Patent CA-3189352-A1 (CA)
Inventor: MOSCHEL SEBASTIAN
IPC: C08K3/32
Filed: 2021-09-16
Abstract: The present invention relates to a composition containing ammonium polyphosphate and at least one alkali metal salt or alkaline-earth metal salt, to a process for preparing the composition and to the use of the composition as a flame retardant and/or coating material.
Patent CA-3190193-A1 (CA)
Title: Snowmobile ski assembly
Inventor: LAURENCE FELIX ANTOINE
Filed: 2015-03-11
Abstract: A snowmobile ski assembly has a ski defining a slot, a ski runner disposed in the slot and being translatable in the slot between a first position and a second position, and a runner adjustment assembly connected to the ski runner. The runner adjustment assembly selectively translates the ski runner between the first and second positions. A  snowmobile having the snowmobile ski assembly and a ski runner are also disclosed.
Patent CA-3192840-A1 (CA)
Title: System for managing building progress on basis of lidar technology
Inventor: LAU WAI MAN RAYMOND
IPC: G06Q10/06
Filed: 2021-10-11
Abstract: A system for managing building progress on the basis of LiDAR technology, the system comprising: a cloud server, wherein the server is loaded with a BIM of a building that is under construction or is in operation; and a handheld measurement device, which is provided with a LiDAR and a positioning apparatus. A user performs scanning at a designated position of a building by holding the LiDAR, so as to obtain, in real time, point cloud data of an on-site building structure, and the point cloud data is transmitted to the cloud server by means of a network; the cloud server compares real-time measurement data with historical measurement data or the BIM of the building to acquire a comparison result and attribute data of building components; and the comparison result is displayed on a display screen of the handheld measurement device by using augmented/mixed reality display technology, such that the user can quickly, directly and clearly know the progress and quality of a project.
Patent CA-3193400-A1 (CA)
Inventor: DECRESCENZO GARY
IPC: A61P17/06
Filed: 2021-09-24
Abstract: The present application relates to a novel crystalline form of ethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (Compound 1). The present application also relates to a method of preparing Compound 1 and a method of preparing crystalline polymorph Form A of Compound 1. Additional aspects of the present application relate to pharmaceutical compositions comprising Compound 1 formed from the crystalline form or the crystalline form of Compound 1.
Patent CA-3193756-A1 (CA)
Inventor: RYDEN-BERGSTEN TINA
IPC: A61P3/06
Filed: 2021-09-16
Abstract: La présente divulgation concerne des dosages et des méthodes de traitement d'une maladie associée à la proprotéine convertase subtilisine/kexine de type 9 (PCSK9). La présente divulgation concerne également des dosages unitaires, des schémas posologiques et des méthodes de traitement d'une maladie associée à la PCSK9.
Patent CA-3194171-A1 (CA)
Inventor: DRESSER SAM
Filed: 2020-06-18
Abstract: A computer-aided method of educating a plurality of music students in an ensemble, including: (i) receiving search parameters from a client device for searching a multidimensional database of songs, the multidimensional database of songs being compiled to include dimensions of at least (a) instrument parts which indicate a music component being played by a particular type of instrument, (b) educational concepts present, (c) one or more proficiency levels for each of the instrument parts; (ii) searching the multidimensional database of songs to retrieve one or more songs that match the received search parameters, the one or more songs being songs that match proficiency levels of the plurality of music students in the ensemble;  (iii) receiving an indication from the client device of a selected song in the one or more songs;  and (iv) providing to the client device method books associated with educational concepts of the selected song.
Patent CA-3195522-A1 (CA)
Inventor: GRAINGER JOHN DAVID
IPC: A61K31/23
Filed: 2021-09-21
Abstract: The invention relates to the use of disconnection agents before, or together with, toxic agents for the treatment of solid tumours.
Patent CA-3196017-A1 (CA)
Inventor: HU YITING
IPC: B25B27/00
Filed: 2021-07-09
Abstract: Outil de soutènement (1), dispositif de montage de boulon (200) et procédé d'assemblage pour un rotor de compresseur haute pression (100). Dans l'outil de soutènement (1), un support (2) est pourvu d'une partie de guidage d'élément de soutènement, d'une partie de guidage d'élément d'extrusion (22) et d'un évidement de guidage d'élément de transmission (23) ; un élément de soutènement (3) est pourvu d'une partie d'accouplement de guidage d'élément de soutènement correspondant en coulissement à la partie de guidage d'élément de soutènement ; un élément d'extrusion (4) est pourvu d'une partie d'accouplement de guidage d'élément d'extrusion (42) correspondant en coulissement à la partie de guidage d'élément d'extrusion (22) ; un levier (5) est articulé sur le support (2) ; un élément de transmission (6) correspond en coulissement à l'évidement de guidage d'élément de transmission (23). L'élément d'extrusion (4) force l'élément de transmission (6) à coulisser, et l'élément de transmission (6) entraîne le levier (5) à tourner pour permettre à l'élément de soutènement (3) de coulisser. Au moyen de la force de réaction agissant sur l'élément d'extrusion (4) par l'élément de transmission (6), et de la force de frottement entre l'élément d'extrusion (4) et le support (2), l'élément d'extrusion (4) est dans un état d'auto-verrouillage par frottement, de telle sorte que l'élément d'extrusion (4) est freiné pour verrouiller l'élément de soutènement (3).
Patent CA-3197232-A1 (CA)
Inventor: Dittmer Andrew
IPC: A61M11/00
Filed: 2021-11-05
Abstract: A surface acoustic wave (SAW) atomizer system for use in providing a nebulized medicament to a patient is described. The system may include a SAW atomization engine with an atomization region on a substrate that is separated from the interdigitated transducers (IDTs) on the substrate by a fluid barrier that seals off liquid fed into the atomization region from the adjacent IDTs and electrical contacts driving the IDTs.
Patent CA-3197414-A1 (CA)
Title: Gene editing with a modified endonuclease
Inventor: STEAD BRENT E
IPC: C12N15/113
Filed: 2021-11-04
Abstract: An engineered nuclease with unique binding and cleavage properties and methods to alter cellular gene expression using said modified endonucleases for gene editing.
Patent CA-3199193-A1 (CA)
Title: Modular individually operable vehicle door
Inventor: GABBIANELLI GIANFRANCO
IPC: E05B85/04
Filed: 2021-12-08
Abstract: A vehicle door system includes doors with a door module attached to a hinge module, which is attached to the vehicle body. The door module includes a latch mechanism configured to engage a striker pin of the vehicle body, with a pawl that pivots to accommodate a misalignment with the striker pin during a door closing operation, with the latch mechanism shifting following engagement with the striker pin. A door check mechanism includes a permanent magnet and a steel plate. Activation of the permanent magnet shifts the steel plate from a closed position to an open position permitting the hinge module to move from a locked position. An interface between doors includes a primary and secondary seal each having a constant cross section, with filler pieces disposed between the door and the secondary seal along a portion of the interface.
Patent CA-3200948-A1 (CA)
Title: Systeme de gestion de sieges de vehicule
Inventor: MEYER DANIEL CHRISTOPHER
IPC: B60N2/02
Filed: 2021-11-03
Abstract: L'invention concerne un système de gestion de sièges de véhicule, configuré pour régler un ou plusieurs sièges en fonction de données d'occupants et/ou de véhicule. Selon un aspect, les données d'occupants et/ou de véhicule peuvent être envoyées à un dispositif distant pour le calcul d'un algorithme de réglage de sièges. Selon un autre aspect, l'algorithme de réglage de sièges peut être envoyé par l'intermédiaire d'une transmission sans fil. Dans un exemple, la transmission sans fil peut être 5G.