baber/WOPTO huggingface dataset:
Patent AT-E277426-T1 (AT)
Inventor: PLESSING ALBERT
IPC: H01L31/048
Filed: 1999-06-30
Granted: 2004-10-15
Abstract: A photovoltaic module (1) in the form of a laminate with a solar cell system (2) as the core between encapsulating materials (3, 3'), in which at least one of these materials (3') comprises a sealing layer (4') and a barrier layer (6) consisting of a plastic film or compound foil with an inorganic oxide layer (7) deposited from the vapor phase. An Independent claim is also included for a process for the production of a module (1) by (a) vapor-phase deposition of an oxide layer (7) on a plastic film or compound foil (6), (b) encapsulation of a solar cell system (2) between sealing layers (4, 4'), (c) transferring the module stack to the loading station of a system in which it is kept at a temperature below the softening point of layers (4, 4'), (d) transferring the stack to a vacuum laminator in which it is heated under vacuum to the softening point of (4, 4') and (e) letting in air without cooling, transferring the composite body to a hardening oven and hardening layers (4, 4') to form a laminated module (2) which is then cooled and taken out for further processing.
Patent AT-E255066-T1 (AT)
Inventor: LEDOUX MARC
IPC: B01J27/30
Filed: 1999-09-21
Granted: 2003-12-15
Abstract: A process for catalytically oxidizing H2S contained in a gas directly to sulphur containing the following steps: combining the H2S-containing gas with a gas containing free oxygen in an amount to produce an oxygen-enriched H2S-containing gas having O2/H2S molar ratio ranging from about 0.05 to about 15; and contacting the oxygen-enriched H2S-containing gas with a catalyst for selective oxidation of H2S to sulphur, wherein the catalyst includes a catalytically active phase combined with a silicon carbide-based support and wherein the active phase of the catalyst consists of at least one oxysulphide of at least one metal selected from the group consisting of iron, copper, nickel, cobalt, chromium, molybdenum and tungsten, at a temperature above the dew point of sulphur formed during H2S oxidation.
Patent AT-E259664-T1 (AT)
Inventor: MUELLER-LIERHEIM WOLFGANG G K
IPC: G02C7/04
Filed: 1999-08-17
Granted: 2004-03-15
Abstract: The invention relates to a device for the care of contact lenses, comprising a container (1), an aqueous 3 % H2O2 solution that may be introduced in the container (1) and a catalyst consisting of a platinum layer to neutralize the H2O2 solution, the surface thereof being in contact with the aqueous H2O2 solution, wherein a silver layer (7) contacts the H2O2 solution with the purpose of improving the oligodynamic effect of the care solution, the surface of said layer having a maximum size of 3.0 mm<2>/ml.
Patent AT-E249102-T1 (AT)
Inventor: MAKKUS ROBERT CHRISTIAAN
IPC: H01M8/14
Filed: 1999-10-08
Granted: 2003-09-15
Abstract: Method for coating a non-oxidised stainless steel support plate and a MCFC fuel cell stack provided with a separator plate coated in this way. First a diffusion barrier layer and then a nickel layer are applied to the anode side of the support plate. The diffusion barrier layer consists of titanium oxide and the adhesion between titanium oxide and the support plate can be improved by providing an adhesion layer.
Patent AT-E256779-T1 (AT)
Inventor: HOSAGASI SEVKI
IPC: D05B29/02
Filed: 1999-09-22
Granted: 2004-01-15
Abstract: An actuating device intended for a sewing device or sewing machine includes a material pressing device for holding down the material to be sewn during stitch formation and transport, and at least one linear motor which serves as regulating element for the material pressing device. The drive rod of the actuating element is connected to the material pressing device so as to control the pressure the pressing device exerts on the material to be sewn. The drive rod is linked to the pressing device via at least one elastic low-mass coupling element and the pressing device can be placed by the linear motor back and forth between a raised and a lowered position.
Patent AT-E337757-T1 (AT)
Inventor: STEINSEIFER ULRICH
IPC: A61F2/24
Filed: 1999-06-02
Granted: 2006-09-15
Abstract: The present invention relates to an improved trileaflet mechanical heart valve 100 and an improved leaflet 110 for use with such valve. The valve 100 and leaflet 110 of the present invention provide improved flow characteristics, minimize blood clotting behind the leaflets, and provide more natural opening and closing times. The valve includes a valve housing 105 which contains pivot/hinge mechanism (130, 200, and 300) for allowing rotation of and retention of the leaflets 110. The valve housing 105 also includes windows or openings 125 which allows for complete washing of the pivot/hinge mechanism (130, 200, and 300) as well as the leaflets 110. The novel leaflets 110 are airfoil-like having a complex S-shaped curvature on their outer surface. This novel geometry, when combined with the location of the leaflet's pivot axis, causes a tendency for the leaflet 110 to rotate towards the closed position. Thus, the leaflet 110 begins to close much earlier than a conventional leaflet and is substantially closed before the flow reverses, similar to the function of a natural valve.
Patent AT-E322505-T1 (AT)
Inventor: EZQUERRO SAENZ IGNACIO JOSE
IPC: A61K45/00
Filed: 1999-11-23
Granted: 2006-04-15
Abstract: Antagonistic synthetic peptides, obtained from TGF beta 1 or from its receptors in the organism, that can be used in the manufacture, both on their own, as well as the gene sequences that encode them and the recombinant systems that express them, in the manufacture of compositions for use in the treatment of liver diseases and more concretely in cases of fibrosis. The said compositions can optionally include mimotopes of the said active peptides.
Patent AT-E292931-T1 (AT)
Inventor: MOUSSY FRANCIS
IPC: A61B5/00
Filed: 1999-11-19
Granted: 2005-04-15
Abstract: A generic implantable puck that can be used with a number of biosensor configurations. This generic implantable potentiostat telemetry unit (the puck) can also be part of a system to detect glucose concentrations. An electrochemical system partially implantable into a body for detecting glucose concentrations therein is presented. The system comprises an electrochemical sensor, a transmitting puck including an electric circuit connected to the electrochemical sensor for transmitting a signal indicative of the glucose concentrations in the body. There is at least one receiver for receiving the signal from the transmitting puck and a computer system coupled tlo the at least one receiver for processing the signal for patient diagnosis and treatment.
Patent AT-E262166-T1 (AT)
Inventor: LAMBSON VERNON A
IPC: G01L3/14
Filed: 1999-10-21
Granted: 2004-04-15
Abstract: A method and apparatus for measuring torque of a rotating shaft is provided. In one embodiment, the apparatus includes a transducer assembly that is attached to a shaft. The transducer assembly includes a first plate member, a plurality of webs extending from the first plate member and a second plate member connected to the webs. A plurality of strain gauges are mounted on the transducer assembly at selected locations and in selected patterns. As torque is applied to the shaft, the torsional load from the shaft causes stress in the first plate member, the web members, and the second plate member. The strain gauges measure this stress and generate signals that provide a measure of the stress. The signals transmitted from the sensing circuit are compared with calibration data, and the torque value is inferred. In one embodiment, the strain gauges are arranged in opposing pairs on the transducer assembly and electrically connected as a Wheatstone bridge, so that strain resulting from non-torsional loads is canceled from the measured signal, thereby improving torque measurement accuracy. In another embodiment, the strain gauges are located on thinned regions in the transducer assembly which are fashioned for the purpose of creating areas of localized high stress. In another embodiment, the transducer assembly includes a decoupling aperture. The decoupling aperture minimizes hysteresis due to warping and bending of the transducer assembly.
Patent DE-05855269-T1 (DE)
Title: Verfahren und vorrichtung zur verwendung verschiedener modulationsverfahren zur übertragung eines pakets
Inventor: AGRAWAL AVNEESH
IPC: H04W72/04
Filed: 2005-12-21
Abstract: Ein
Verfahren zum Übertragen
von Daten in einem Kommunikationssystem, aufweisend:  Kodieren
eines Datenpakets, um eine Mehrzahl von Code-Bits für das Datenpaket
zu erhalten;  Bilden einer Mehrzahl von Blöcken von Code-Bits mit der Mehrzahl
von Code-Bits;  Bestimmen eines Modulationsschemas, um es für jeden der
Mehrzahl der Blöcke
zu verwenden, wobei wenigstens zwei verschiedene Modulationsschemata
für die
Mehrzahl der Blöcke
benutzt werden; und  Abbilden der Code-Bits in jeden der Mehrzahl
der Blöcke
in Übereinstimmung
mit dem Modulationsschema, das für den
Block benutzt wird, um Modulationssymbole für den Block zu erzeugen, wobei
eine Mehrzahl von Blöcken
von Modulationssymbolen für
die Mehrzahl von Blöcken
von Code-Bits erzeugt wird.
Patent DE-96712-T1 (DE)
IPC: G10L15/02
Filed: 1982-12-07
Abstract: The present invention relates to a speech recognition system and the method therefor, which analyzes a sampled clipped speech signal for identifying a spoken utterance. An input signal representative of the spoken utterance is passed through a clipper to generate a clipped input signal. A sampler generates a plurality of discrete binary values, each discrete binary value corresponding to a sample value of the clipped input signal. A processor then analyzes the plurality of sample values thereby identifying the spoken utterance. Analysis includes determining linear prediction coefficients of the autocorrelation function of speech utterences.
Patent DE-206636-T1 (DE)
IPC: A01K5/02
Filed: 1986-06-10
Abstract: © A feeder unit for animals, particularly pigs, provides feed in either wet or dry condition and comprises a trough (10) and a shelf (31) positioned above the trough with a water supply duct (43) beneath the shelf (31) for directing water through valves (47) actuated by the pig into the trough. A hopper (19) positioned above the shelf directs material continuously onto the shelf (31) to be retained on the shelf by the repose angle. The pig can thus either eat directly from the shelf (31) the feed in dry condition or can brush the feed into the trough (10) for mixing with water and eating in wet condition.
Patent DE-314577-T1 (DE)
IPC: F16K17/38
Filed: 1988-10-27
Abstract: Hot fluid (that is, liquid or gas) pipeline relief valve arranged downstream of a heat generator or of any other device emitting heat whether by design or accidentally, for example an air compressor, and upstream of the hot fluid circuit portion to be protected, preferably on a branch connected to an outlet or return pipe, characterised in that the opening of the body (9) of the valve connected to the pipe (8) is at least partly obstructed by a breakable bulb (19) filled with a liquid that expands with an increase in the temperature of the fluid conveyed by the pipeline, said bulb (19) being arranged inside the body (9) of the valve (7) in order to be in contact with the conveyed fluid. <IMAGE>
Patent DE-707911-T1 (DE)
Inventor: SATRAN AMIR
IPC: B23C5/20
Filed: 1995-10-19
Abstract: An exchangeable, indexable cutting insert of substantially prismatic shape having an upper rake surface (2), an opposite, substantially parallel base surface and side surfaces (3) with each pair of side surfaces intersecting at an insert corner, each side surface intersecting with said rake surface so as to define a cutting edge (5), each cutting edge comprising a major cutting edge portion (5a) extending from one insert corner and a succeeding minor cutting edge portion (5b) terminating in a successive insert corner, and chip diverting ribs (12) respectively associated with said cutting edges and formed on said rake surface, each rib (12) extending from a region adjacent the merging of said major and minor portions of the associated cutting edge so as to be substantially coextensive with said region and so as to be spaced therefrom by a portion of said rake surface. <IMAGE>
Patent ES-2085844-T1 (ES)
Inventor: CAER YVES
IPC: B65D88/16
Filed: 1995-03-27
Abstract: The procedure consists of making the container (1) with a lifting handle (2) at its upper end, formed by pleating and joining a layer of the material which contains all the lengthwise fibres of the container's material. The handle is made by placing a reinforcing element (4) on one side of the layer of material before pleating, pleating both the layer of container material and the reinforcing element together and then joining the pleats together, eg. with adhesive and temporary stitching (5), or by means of permanent seams or welds. The container is made on a machine which incorporates a pleat-folding mechanism with moving metal plates and actuators. <IMAGE>
Patent CY-1110696-T1 (CY)
Title: Διαδικασια για την παραγωγη ενος κατεψυγμενου προϊοντος διατροφης
Inventor: BARFOD NIELS MICHAEL
IPC: A23L29/10
Filed: 2010-01-05
Abstract: Η παρούσα εφεύρεση παρέχει μια διαδικασία για την παραγωγή ενός κατεψυγμένου προϊόντος διατροφής η οποία περιλαμβάνει το στάδιο της επαφής ενός ενδιάμεσου τροφίμου με ένα σύστημα γαλακτωματοποιητή, όπου το σύστημα γαλακτωματοποιητή αποτελείται βασικά από ενώσεις του τύπου (I) όπου R1 είναι μια υδρογονανθρακική ομάδα˙ και κατ' επιλογή μονο-διγλυκερίδια και/ή ακόρεστα λακτυλιωμένα μονο-διγλυκερίδια.
Patent CY-1109864-T1 (CY)
Inventor: TUSCHL THOMAS
IPC: C07H/
Filed: 2010-03-02
Abstract: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function.; The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response. This specific targeting of a particular gene function is useful in functional genomic and therapeutic applications.
Patent CY-1113935-T1 (CY)
Title: Τρι-πεπτιδια αναστολεις ηπατιτιδας c
Inventor: SIMONEAU BRUNO
IPC: A61K38/06
Filed: 2013-04-18
Abstract: Ρακεμικά, διαστερεοϊσομερή και οπτικά ισομερή μίας ένωσης με τύπο (I):
Patent CY-1114468-T1 (CY)
Title: Ροφλουμιλαστη για τη θεραπεια της πνευμονικης υπερτασης
Inventor: BEUME ROLF
IPC: A61P9/12
Filed: 2013-10-09
Abstract: Η εφεύρεση σχετίζεται με τη χρήση Ροφλουμιλάστης, Ροφλουμιλάστης-Ν-οξειδίου ή ενός φαρμακευτικώς αποδεκτού άλατος οποιουδήποτε από τα δύο για τη θεραπεία της πνευμονικής υπέρτασης. Η εφεύρεση επίσης σχετίζεται με τη χρήση Ροφλουμιλάστης, Ροφλουμιλάστης-Ν-οξειδίου ή ενός φαρμακευτικώς αποδεκτού άλατος οποιουδήποτε από τα δύο σε συνδυασμό με έναν αναστολέα ΡDΕ5 ή ένα φαρμακευτικώς αποδεκτό άλας αυτού για τη θεραπεία της πνευμονικής υπέρτασης.
Patent CY-1116194-T1 (CY)
Title: Σκευασμα οιστραδιολης-προγεστερονης βραδειας αποδeσμευσης
Inventor: SAVOIR JOHN CLAUDE
IPC: A61K31/57
Filed: 2015-04-09
Abstract: Η παρούσα εφεύρεση παρέχει σκευάσματα οιστραδιόλης-προγεστερόνης βραδείας αποδέσμευσης τα οποία είναι δυνατό να χρησιμοποιηθούν είτε σε θεραπεία αντισύλληψης είτε σε θεραπεία ορμονικής υποκατάστασης. Τα σκευάσματα περιέχουν μορφοποιημένα σωματίδια οιστραδιόλης που βρίσκονται σε ημι-κρυσταλλική μορφή και παρουσιάζουν ιδιαίτερα χαμηλούς ρυθμούς διάλυσης. Τα μορφοποιημένα σωματίδια περιέχουν οιστραδιόλη και βρίσκονται στη σύνθεση σε μία γραμμομοριακή αναλογία 1:1 με χοληστερόλη, και χορηγούνται σε συνδυασμό με προγεστερόνη. Τα σκευάσματα βραδείας αποδέσμευσης της παρούσας εφεύρεσης προσφέρουν τα δύο πλεονεκτήματα ενός σκευάσματος σε χαμηλή δόση οιστραδιόλης με ένα δοσολογικό σχήμα μικρής συχνότητας. Τα σκευάσματα είναι δυνατό να χορηγηθούν από την παρεντερική οδό μία φορά το μήνα ή σπανιότερα.
Patent CY-1118889-T1 (CY)
Title: Καθετηρας για την ελαχιστοποιηση της αραιωσης δοσολογιας κατα τη διαρκεια της χορηγησης μονοξειδιου του αζωτου
Inventor: FLANAGAN CRAIG
IPC: A61M16/20
Filed: 2017-05-15
Abstract: Η παρούσα εφεύρεση γενικά αφορά, μεταξύ άλλων, συστήματα, συσκευές, υλικά και μεθόδους που μπορούν να βελτιώσουν την ορθότητα και/ή την ακρίβεια της θεραπείας μονοξειδίου του αζώτου, παραδείγματος χάριν, δια μείωσης του εισπνεόμενου μονοξειδίου του αζώτου (NO). Όπως περιγράφεται στην παρούσα, η αραίωση του NO μπορεί να παρουσιασθεί λόγω διαφόρων παραγόντων. Προκειμένου να μειωθεί η αραίωση μίας επιδιωκόμενης δόσης NO, αποκαλύπτονται διάφοροι παραδειγματικοί ρινικοί καθετήρες, διαμορφώσεις πνευματικών διατάξεων, μέθοδοι κατασκευής και μέθοδοι χρήσης, κτλ.
Patent CY-1120370-T1 (CY)
Title: Φυλλο για δερματικη εφαρμογη που περιεχει βιταμινη ε ή εναν εστερα αυτης
Inventor: PANIN GIORGIO
IPC: A61L15/44
Filed: 2018-04-30
Abstract: Φύλλο για δερματική εφαρμογή που περιλαμβάνει μια βοηθητική στρώση η οποία παρασκευάζεται από ύφασμα χαλαρής πλέξης ενσωματωμένο σε μια στρώση ελαστομερούς σιλικόνης που ενσωματώνει βιταμίνη Ε ή έναν εστέρα αυτής, όπου η στρώση ελαστομερούς σιλικόνης έχει πάχος μικρότερο από ή ίσο με 2,0 mm και το ελαστομερές σιλικόνης περιέχει έναν τροποποιητή ελαστικότητας που αποτελείται από ένα τριγλυκερίδιο κορεσμένων C8-C18 λιπαρών οξέων.
Patent CY-1120571-T1 (CY)
Title: Μετρητης
Inventor: BACON RAYMOND
IPC: G06M1/24
Filed: 2018-08-10
Abstract: Η παρούσα εφεύρεση παρέχει έναν μετρητή (203) ο οποίος απαρτίζεται από: ένα πρώτο μέλος δακτυλίου (201) που έχει πρώτες ενδείξεις και ένα δεύτερο μέλος δακτυλίου (202) που έχει δεύτερες ενδείξεις, με καθένα από τα εν λόγω πρώτο και δεύτερο μέλη δακτυλίου να μπορεί να περιστρέφεται κατά βήματα γύρω από έναν κοινό άξονα, με μια ή αμφότερες τις εν λόγω πρώτες και δεύτερες ενδείξεις να υποδεικνύουν μια μέτρηση, και έναν μηχανισμό οδήγησης (205) για την περιστροφή του εν λόγω πρώτου μέλους δακτυλίου και για την περιστροφή του δεύτερου μέλους δακτυλίου μετά από μια ή περισσότερες προκαθορισμένες μοίρες περιστροφής του πρώτου μέλους δακτυλίου, όπου ο εν λόγω μηχανισμός οδήγησης αποτελείται από έναν μηχανισμό καστάνιας και δοντιών που απαρτίζεται από μια πρώτη και δεύτερη καστάνια (208) που μπορούν να συνδεθούν με μια πληθώρα δοντιών, και όπου καθεμιά από τις εν λόγω πρώτη και δεύτερη καστανιά αποτελούνται από μια επιφάνεια σύνδεσης οδήγησης για τη σύνδεση σε μια σύνδεση οδήγησης με ένα από την εν λόγω πληθώρα δοντιών, και μια επιφάνεια σύνδεσης ολίσθησης για την ολίσθηση επάνω από ένα από την εν λόγω πληθώρα δοντιών.
Patent CY-1122980-T1 (CY)
Title: Φαρμακευτικο σκευασμα που περιεχει ινοσιτολη
Inventor: UNFER VITTORIO
IPC: A61K9/48
Filed: 2020-06-02
Abstract: Η παρούσα εφεύρεση αναφέρεται σε μια φαρμακευτική σύνθεση που περιέχει διαλύματα, εναιωρήματα ή διασπορές ινοσιτόλης, ή ενός ισομερούς αυτής, σε έναν φορέα που περιέχει ζελατίνη, γλυκερόλη ή μείγματα αυτών.
Patent CY-1125039-T1 (CY)
Title: Νεα χρηση του ν,ν-δις-2-μερκαπτοαιθυλ ισοφθαλαμιδιου
Inventor: HALEY BOYD EUGENE
IPC: A61K31/166
Filed: 2022-03-01
Abstract: Παρέχεται η ένωση Ν,Ν-δις-μερκαπτοαιθυλ ισοφθαλαμίδιο (ΝΒΜΙ), ή ένα φαρμακευτικά-αποδεκτό άλας και/ή παράγωγο αυτής, για χρήση στη θεραπεία ή την πρόληψη της τοξικότητας από παρακεταμόλη. Τέτοιες ενώσεις έχουν ιδιαίτερη χρησιμότητα στη θεραπεία ή την πρόληψη οξείας ηπατικής ανεπάρκειας που σχετίζεται με τοξικότητα παρακεταμόλης.
Patent GR-930300127-T1 (GR)
Title: Abrasive in cosmetic products, process for their production and their uses.
Inventor: BOUILLON GUENTER
IPC: C11D3/382
Filed: 1993-12-30
Abstract: The present invention is directed to an abrasive for use in a skin cleansing agent. The abrasive comprises a bleached flour obtained from a natural shell, kernel or mixture thereof. A preferred bleaching agent is hydrogen peroxide. The natural shells and/or kernels may be, for example, walnut shells, almond shells, hazelnut shells, olive kernels, cherry kernels, apricot kernels or mixtures thereof.
Patent HR-P20110288-T1 (HR)
Inventor: QU BINGYU
IPC: H04J11/00
Filed: 2011-04-19
Abstract: Postupak obrade sekvenci u komunikacijskom sustavu, naznačen time da se sastoji od: dobivanja (201) broja skupine k skupine sekvence koji se dodjeljuje od strane sustava, te je skupina sekvence sastavljena od višestrukih podskupina, te svaka podskupina odgovara svojem vlastitom načinu zauzimanja vremensko frekvencijskih resursa; odabira (202) n sekvenci iz zbirke sekvenci kandidata da formiraju sekvence u podskupini i u skupini sekvence k; n sekvenci daje najmanju vrijednost funkcije |ri/Ni - ck/Np1| ili |(ri/Ni - ck/Np1) modu mk,i|, te drugu najmanju, sve do odgovarajuće n-te najmanje; pri čemu n je prirodni broj, i je serijski broj podskupine; pri čemu Np1 je duljina referentne podskupine sekvence, ck je osnovni indeks sekvence za sekvencu sa duljinom Np1 koji je određen sa skupinom sekvence k ; pri čemu ri je osnovni indeks sekvence u zbirci sekvenci kandidata, i Ni je duljina sekvence u zbirci sekvenci kandidata; pri čemu je mk,i varijabla ovisna o broju skupine k i broju podskupine i; pri čemu modu operator predstavlja vrijednost modula uključenu u (-mk,i/2, mk,i/2]; generiranja (203) odgovarajućih sekvenci prema sekvencama u kreiranoj podskupini; iodašiljanja ili prijema sekvenci u vremensko frekvencijskim resursima koji odgovaraju podskupini i. Patent sadrži još 14 patentnih zahtjeva.
Patent HR-P20110644-T1 (HR)
Inventor: HELMREICH MATTHIAS
IPC: C07D251/10
Filed: 2011-09-07
Abstract: Postupak pripreme spojeva formule IgdjeR1, R2 svaki, nezavisno jedan od drugog, predstavljaju H ili A, R3, R4 svaki, nezavisno jedan od drugog, predstavljaju H, A, alkenil s 2-6 C atoma, alkinil s 2-6 C atoma, Ar ili Het, R5 i R6 zajedno također predstavljaju alkilen s 2, 3, 4 ili 5 C atoma, R5, R6 svaki, nezavisno jedan od drugog, predstavljaju H, A, (CH2)nAr, (CH2)mOAr, (CH2)mOA ili (CH2)mOH, R5 i R6 zajedno također predstavljaju alkilen s 2, 3, 4 ili 5 C atoma, gdje se jedna CH2 skupina može zamijeniti s O, NH ili NA i/ili gdje se 1 H atom može zamijeniti s OH, Ar predstavlja fenil, naftil ili bifenil, od kojih je svaki nesupstituiran ili je mono-, di- ili trisupstituiran halogenom, A, OA, OH, COOH, COOA, CN, NH2, NHA, NA2, SO2A i/ili COA, Het predstavlja mono-, bi- ili triciklički zasićeni, nezasićeni ili aromatski heterocikl s 1 do 4 N, O i/ili S atoma, koji može biti nesupstituiran ili je mono-, di- ili trisupstituiran halogenom, A, OH, OA, NH2, (CH2)nAr, NHA, NA2, COOH, COOA i/ili =O (karbonil kisik), A predstavlja nerazgranati ili razgranati alkil s 1-10 C atoma, gdje se 1-7 H atoma može zamijeniti s F, ili ciklički alkil s 3-7 C atoma, halogen predstavlja F, Cl, Br ili I, m predstavlja 1, 2, 3, 4, 5 ili 6, n predstavlja 0, 1 ili 2, i njegovih kiselih-adicijskih soli, koji obuhvaća reakciju spoja formule IIgdjeR1, R2, R3, R4 predstavljaju kako je gore naznačeno, sa spojem formule IIIgdjeR5, R6 predstavljaju kako je gore naznačeno. Patent sadrži još 8 patentnih zahtjeva.
Patent HR-P20130707-T1 (HR)
Title: Compositions and uses for treating multiple sclerosis
Inventor: LUKASHEV MATVEY E
IPC: G01N33/68
Filed: 2013-07-25
Abstract: Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.