baber/WOPTO huggingface dataset:
Patent AU-6401296-A (AU)
Title: Compositions and methods using myelin-associated glycoprotein (mag) and inhibitors thereof
Inventor: FILBIN MARIE T
IPC: A61K38/17
Filed: 1996-06-27
Abstract: This invention relates to the novel identification of myelin-associated glycoprotein ("MAG") as a potent inhibitor of neural regeneration. More particularly, this invention relates to compositions and methods useful for reversing inhibition of neural regeneration in the central and peripheral nervous system. Assays to monitor the effects of MAG on neural regeneration and to identify agents which will block or promote the inhibitory effects of MAG on neural outgrowth are provided. Screening methods for identifying such agents are also provided. This invention also relates to compositions and methods using agents that can reverse the inhibitory effects of MAG on neural regeneration. Methods for regulating and for promoting neural growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with disorders or diseases, comprising the step of administering at least one of the compositions according to this invention are provided.
Patent AU-6408894-A (AU)
Title: 2-substituted morpholine and thiomorpholine derivatives as gaba-b antagonists
Inventor: KUO SHEN-CHUN
IPC: C07F9/6533
Filed: 1994-03-23
Abstract: PCT No. PCT/US94/02803 Sec. 371 Date Sep. 22, 1995 Sec. 102(e) Date Sep. 22, 1995 PCT Filed Mar. 23, 1994 PCT Pub. No. WO94/22843 PCT Pub. Date Oct. 13, 1994Disclosed are compounds of the formula I wherein: Y represents -CO2H, -CO2R6, -C(O)NHR7, -SO2H, -SO3H, -SO3R6, -SO2NHR7, -C(O)-N(OH)-R8, or a group of the formula  or a pharmaceutically acceptable addition salt or solvate thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I. Further disclosed is a method for treating or preventing respiratory depression, epileptic seizures or other central nervous system disorders, and for enhancing cognitive performance, by administering an effective amount of a compound of Formula I.
Patent AU-6445300-A (AU)
Title: Apparatus for supporting material to be treated in continuously operated thermaltreatment furnaces
Inventor: YRJANA TAISTO
IPC: C21D9/56
Filed: 2000-08-03
Abstract: The invention relates to an apparatus for supporting material to be treated in continuously operated thermal treatment furnaces, wherein the support of the material is carried out by means of support elements external to the furnace, and where the material is made to proceed at a high velocity, said apparatus comprising at least two elements for supporting the material and a member for supporting the support element, as well as means for cooling the support element. According to the invention, the support element comprises at least one rotation support member provided with a turnably installed tightening element, and at least one actuator arrangement for making the support element rotate essentially at an equal circumferential velocity as the proceeding direction of the material.
Patent AU-6620286-A (AU)
Title: Improvement to two stroke internal combustion engines and implementation method
Inventor: MELCHIOR JEAN FREDERIC
IPC: F02B75/02
Filed: 1986-11-05
Abstract: The engine, operating on the two-stroke cycle, is characterised in that the admission and exhaust distributing elements are valves (7, 9), their control elements being sensitive to a parameter such as the speed of rotation of the engine, the fuel consumption, the supercharging pressure value, the difference between intake and exhaust pressure, in order to vary the angular opening and closing position of the valves (7, 9) to ensure that a sufficient quantity of fresh air is admitted into the working chamber, under the least favourable conditions, in particular by opening the intake during a period when the volume of the chamber is increased. <IMAGE>
Patent AU-6727590-A (AU)
Title: Method for the preparation and purification of a mixture of glycosphingolipids free from contamination by non-conventional viruses
Inventor: VALLE FRANCESCO DELLA
IPC: C07H15/04
Filed: 1990-11-16
Abstract: The process of the invention relates to a process for the preparation of a ganglioside mixture, free from contaminants associated with non-conventional, life-threatening viruses, without altering the biological and pharmacological characteristics of the mixture on the central and peripheral nervous systems.
Patent AU-7112894-A (AU)
Title: Multi-layered tissue paper web comprising biodegradable chemical softening compositions and binder materials and process for making the same
Inventor: PHAN DEAN VAN
IPC: D21H27/38
Filed: 1994-06-17
Abstract: Multi-layered tissue paper webs comprising biodegradable chemical softener compositions and binder materials are disclosed. The multi-layered tissue webs are useful in the manufacture of soft, absorbent paper products such as facial tissues and/or toilet tissues. The multi-layered tissue paper products contain a biodegradable chemical softening composition, preferably comprising a mixture of an ester-functional quaternary ammonium compound and a polyhydroxy compound. Preferred ester-functional quaternary ammonium compounds include diester dialkyl dimethyl ammonium salts such as diester di(touch hardened)tallow dimethyl ammonium chloride, diester di(hydrogenated)tallow dimethyl ammonium chloride. Preferred polyhydroxy compounds are selected from the group consisting of glycerol, sorbitols, polyglycerols having a weight average molecular weight of from about 150 to about 800, polyoxyethylene glycols and polyoxypropylene glycols having a weight average molecular weight from about 200 to 4,000. The multi-layered tissue paper webs also contain an effective amount of binder materials to control linting and/or to offset the loss in tensile strength, if any, resulting from the use of the chemical softening compositions. The binder materials are selected from the various wet and dry strength additives, and retention aids used in the paper making art. Preferably, the majority of the biodegradable chemical softening compositions will be disposed on the outer layers of the multi-layered tissue paper products where they are most effective. The binder materials are typically dispersed throughout the multi-layered product to control linting. In other words, the chemical softening compositions and the binder materials can be selectively distributed within the multi-layered tissue paper web to enhance the softness, absorbency, and/or lint resistance of a particular layer or ply.
Patent AU-7187981-A (AU)
Title: Aryloxypropanolamines
Inventor: WIEDEMANN F
IPC: C07D239/95
Filed: 1981-06-16
Abstract: The present invention provides aryloxypropanolamines of the general formula:   <IMAGE>   wherein R1, R2, R3 and R4, which may be the same or different, are hydrogen or halogen atoms or lower alkyl, cyano, carboxamide, hydroxyl, lower acyloxy, lower alkoxy, lower alkenyloxy or aryl lower alkoxy radicals, R5 and R6, which may be the same or different, are hydrogen atoms or lower alkyl radicals, X is a straight or branched alkylene chain containing 2 to 6 carbon atoms, A is a mono-, bi- or tricyclic heteroaromatic or hydroheteroaromatic radical or, when at least one of the symbols R1, R2, R3 and R4 is other than a hydrogen atom, may also be a phenyl radical, with the proviso that when A is a uracil-6-yl radical, the 5-position of the uracil moiety does not contain a hydrogen atom, R7, R8, R9, R10 and R11, which may be the same or different, are mono- or divalent substituents selected from hydrogen, halogen, notro, hydraxylamino, amino, lower acylamino, lower alkylamino, di-(lower alkyl)-amino, hydroxyethylamino, di-(hydroxyethyl)-amino, hydroxyl, lower alkoxy, allyloxy, methoxy lower alkoxy, cyano, carboxamido, carboxy, lower alkoxycarbonyl, hydroxymethyl, lower alkoxymethyl, halomethyl, aminomethyl, lower acylaminomethyl, halomethyl, aminomethyl, lower acylaminomethyl, di(lower alkyl)-aminomethyl, pyrrolidinomethyl, piperidinomethyl, di-(hydroxyethyl)-amino, hydroxyl, lower alkoxy, allyloxy, methoxy lower alkoxy, cyano, carboxamido, carboxy, lower alkoxycarbonyl, hydroxymethyl, lower alkoxymethyl, halomethyl, aminomethyl, lower acyaminomethyl, di-(lower alkyl)-aminomethyl, pyrrolidinomethyl, piperidinomethyl, di-(hydroxyethyl)-aminomethyl, morpholinomethyl, piperazinomethyl, 4-lower acylpiperazinomethyl, 4-lower alkylpiperazinomethyl, lower alkyl, lower alkenyl, 2-cyanoethyl, 2-hydroxyethyl, phenyl lower alkyl and phenyl, the phenyl radicals being optionally substituted with 1 or 2 hydroxyl or methoxy radicals, or from oxygen or sulphur; the optically-active forms and the racemic mixtures thereof, and the pharmacologically compatible salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. These compounds are useful for the prophylaxis and combatting of cardiac and circulatory diseases.
Patent AU-7195794-A (AU)
Title: Fused benzazepine derivative and pharmaceutical composition containing the same
Inventor: TANAKA AKIHIRO
IPC: C07D498/04
Filed: 1994-07-19
Abstract: (Biphenyl-2-ylcarboxamide)benzoic acid is useful on an intermediate for the synthesis of condensed benzazepine derivatives which are arginine vasopressin antagonists.
Patent AU-7347298-A (AU)
Title: Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
Inventor: JIANG QINGPING
IPC: C09K11/07
Filed: 1998-05-29
Abstract: A new class of chemiluminescent acridinium or benzacridinium compounds is disclosed by virtue of forming an intramolecular energy transfer conjugate (ETC) between the acridinium or benzacridinium compound and a luminophore. A method of extending the emission wavelengths of acridinium or benzacridinium esters in order to further reduce or eliminate the emission spectral overlap between the parent polysubstituted aryl Acridinium Esters (DMAE) and Benzacridinium Esters (LEAE) is disclosed. The ETC's retain the unique desired properties of acridinium or benzacridinium compounds including complete light emission in very short period of time, monophasic emission spectrum, simplicity of triggering mechanism, ability of labeling the biological molecules of interest to form a tracer, and good stability. Additionally, the range of the emission spectrum of an acridinium or benzacridinium compound can now be shifted at will and at longer leap through the choice of a luminophore as the integral part of an ETC molecule. Disclosed are chemiluminescent labeled conjugates comprising an acridinium or benzacridinium moiety covalently attached to a luminophore via a spacer, said moiety further conjugated to a biological molecule of interest, wherein said spacer is of an appropriate length to allow the excited species generated from said moiety to transfer energy efficiently to said luminophore, resulting in the emission of light in the spectral region of said luminophore. Also disclosed are binding assays using said conjugates, test kits comprising said conjugates and methods of preparing the conjugates.
Patent AU-7523896-A (AU)
Title: Methods and compositions using butyrate esters of threitol
Inventor: BEMIS GUY W
IPC: A61K31/22
Filed: 1996-10-30
Abstract: The present invention relates to the use of butyrate esters of threitol, alone or in combination with other agents, in pharmaceutical compositions and methods for increasing fetal hemoglobin and gamma globin in a patient. These methods are particularly useful in treating  beta -hemoglobinopathies, such as sickle cell syndromes and  beta -thalassemia syndromes. Compositions comprising butyrate esters of threitol, alone or in combination antiproliferative and differentiating agents are also useful in methods for inducing cell differentiation in malignant cells. These methods are useful in treating cancer, particularly the tetrabutyrate ester.
Patent AU-7588200-A (AU)
Title: Oncolytic virus
Inventor: BELL JOHN CAMERON
IPC: A61K35/76
Filed: 2000-09-18
Abstract: The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterised by having low levels, or no PKR activity, or as being PKR-/-, STAT1-/- or both PKR-/- and STAT-/-. The virus is selected from the group consisting of Rhabdovirus and picornavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.
Patent AU-7631781-A (AU)
Title: Connection for furniture frame parts
Inventor: BECKER NORBERT
IPC: F16B12/32
Filed: 1981-10-14
Abstract: A furniture frame includes a first frame part with a dowel extending beyond the end thereof into an opening in a second frame part. A securing screw is provided in the second frame part at right-angles to the dowel axis. When the screw is tightened, two abutting surfaces inclined at an angle to the central plane of the dowel are pressed against corresponding, inclined surfaces in the opening. A releasable, but nevertheless very rigid connection of the various elements is thus achieved.
Patent AU-7673091-A (AU)
Title: Tetra-aza macrocycles, processes for their preparation and their use in magnetic resonance imaging
Inventor: PARKER DAVID
IPC: A61K49/06
Filed: 1991-04-18
Abstract: Metal complex of tetra-aza macrocycles of formula (1) <CHEM> wherein Alk<1>, Alk<2>, Alk<3> and Alk<4>, which may be the same or different, is each a C1-4alkylene chain optionally substituted by one or more optionally substituted C1-6alkyl groups; and R<1>, R<2>, R<3> and R<4> which may be the same or different is each a hydrogen atom or a group AlkR<5> where Alk is an optionally substituted straight or branched C1-6alkyl group R<5> is a hydrogen atom or a -CO2H, -CONR<6>R<7> [where R<6> and R<7>, which may be the same or different, is each a hydrogen atom or C1-6alkyl group] or -P(X<1>) (X<2>R<8>)R<9> group where X<1> and X<2>, which may be the same or different is each an oxygen or sulphur atom, R<8> is a hydrogen atom or an alkyl group and R<9> is an alphatic, aromatic or heteroaromatic group, with the proviso that at least two of R<1>, R<2>, R<3> and R<4> is a group -Alk P(X<1>) (X<2>R<8>)R<9> or one R<1>, R<2>, R<3> and R<4> is a group -Alk P(X<1>) (X<2>R<8>)R<9> and at least one of the remaining groups R<1>, R<2>, R<3> and R<4> is a group -AlkCO2H or -AlkCONR<6>R<7>, or a salt thereof, for use as contrast agents in nuclear magnetic resonance imaging are described.
Patent AU-7710098-A (AU)
Title: Methods for treating thrombotic disorders
Inventor: GRINNELL BRIAN WILLIAM
IPC: A61K31/00
Filed: 1998-06-01
Abstract: The present invention provides a method of treatment for patients with a variety of thrombotic disorders including, but not limited to, stroke, venous thrombosis, myocardial infarction, unstable angina, abrupt closure following angioplasty or stent placement, and thrombosis as a result of peripheral vascular surgery. Said treatment is a combination therapy with human aPC and antiplatelet agents including, but not limited to, aspirin (ASA), clopidogrel, ReoPro TM (abciximab), dipyridamole, ticlopidine and IIb/IIIa receptor antagonists. The synergy will result in the ability to reduce the dosages of the agents used in the combination therapy.
Patent AU-7973001-A (AU)
Title: Method and device for uphill casting, comprising a chill or core stackings with an open pouring gate
Inventor: MULLER WOLFGANG
IPC: B22D18/04
Filed: 2001-07-10
Abstract: A method for uphill/low-pressure casting, especially of light metal alloys, with a casting table having a flow-through opening, with a casting furnace lying below the casting table with a riser pipe forming an upwardly open mouth opening, with a mould having a base plate which has a downwardly open pouring-in opening; the mouth opening is positioned against the flow-through opening in a sealing fashion from below, the mould is brought with its pouring-in opening over the flow-through opening, melt is conveyed from the casting furnace via the riser pipe into the mould until it is filled, the mould is displaced horizontally on the casting furnace with open melt-filled communication between the casting furnace and the mould until the pouring-in opening is closed by the casting table below and the flow-through opening is closed by the base plate above, the melt is allowed to drop in the riser pipe as far as below the mouth opening.
Patent AU-7997482-A (AU)
Title: Multistage reactor for hydrogenating oil slurry
Inventor: SCHULZ RUDI
IPC: C10G1/06
Filed: 1982-01-29
Abstract: A multi-stage reactor for hydrogenating coal slurry in a pressure vessel for pressures of up to 700 bar, preferably of up to 350 bar, with inlets for gas and coal slurry through the reactor bottom, an outlet for sludge, gases and vapors in the reactor top, and dividing trays in the pressure vessel, by means of which trays the individual reaction stages are separated from one another, wherein each dividing tray has a progressively reducing cross-section, with passage orifices, over its entire lowr face, so as to prevent coal slurry caking onto the tray in the direction of flow of the reactants (gas and coal slurry).
Patent AU-8018594-A (AU)
Title: Turbulence inhibiting tundish and impact pad
Inventor: SAYLOR KARL J
IPC: B22D41/02
Filed: 1994-10-17
Abstract: A tundish and, more specifically, an impact pad is formed with a bottom impact surface and includes an outer side wall extending upwardly therefrom which fully encloses an interior space or cavity having an upper opening into which molten metal is directed from a ladle shroud. The outer side wall of the pad includes an inner surface extending from the bottom impact surface to the opening of the pad. The inner side wall surface includes an annular portion which extends inwardly and upwardly toward the opening of the pad. In the preferred embodiment, the inner side wall surface curves continuously from the bottom impact surface to a vertical wall defining the opening of the pad. The pad redirects the pouring stream back into itself causing the counter current flows to slow each other down thereby minimizing turbulence and inhibiting high velocity flow within the tundish. The upward flow is further is advantageously directed away from the incoming pouring stream toward the surface of the bath.
Patent AU-8153394-A (AU)
Title: Electron source and electron beam apparatus
Inventor: MITSUTAKE HIDEAKI
IPC: H01J1/316
Filed: 1994-12-19
Abstract: An electron source or electron beam apparatus comprises an electron-emitting device and a shield member disposed above the electron-emitting device. The electron-emitting device generates an electric field component, when energized, that is parallel to a substrate surface on which the electron-emitting device is disposed, while the shield member allows electrons emitted from the electron-emitting device to pass therethrough, but blocks off charged particles flying toward the electron emitting device. <IMAGE>
Patent AU-8456791-A (AU)
Title: Antiemulsion/antifoam agent for use in oils
Inventor: GALIC MARY
IPC: C10M167/00
Filed: 1991-09-18
Abstract: The present invention deals with a particular antiemulsion agent which is useful in retarding foam and/or emulsion formation in an engine. In particular, the agent is effective at preventing or retarding emulsion or foaming in an engine oil.
Patent AU-8506191-A (AU)
Title: Flame retardant brominated styrene-based coatings
Inventor: ROSE RICHARD S
IPC: C09D133/00
Filed: 1991-08-21
Abstract: Improved flame retardant latex coatings are disclosed which comprise copolymers of ring-halogenated aromatic monomer units and alkyl acrylate/methacrylate monomer units, and which may additionally include at least one other monomer. In a first embodiment, the coatings include ring-brominated aromatic monomer units and alkyl acrylate and/or alkyl methacrylate monomer units. In a second embodiment, the coatings include these first two types of monomer units and further include third monomer units from unsaturated esters of saturated carboxylic acids, halogen-free aromatic monomers or unsaturated carboxylic or dicarboxylic acid monomers. In a third embodiment, the coatings include four monomer units, namely ring-brominated aromatic monomer units, alkyl acrylate/methacrylate monomer units, halogen-free aromatic monomer units and unsaturated carboxylic or dicarboxylic acid monomer units. In one aspect, the halogenated aromatic monomers are present in an amount to provide from 7 to 20 weight percent bromine in the final latex coating. In another aspect, the halogenated aromatic monomers include polybrominated monomers, particularly to provide monomers having an average of at least about 1.5 bromines per monomer unit. The coating polymers have glass transition temperatures in the -30 degrees C. to 30 degrees C. range and are useful, for example, for coating, paint, adhesive, sealant and non-woven binder applications.
Patent AU-8648491-A (AU)
Title: An injection unit
Inventor: BONNICHSEN FRITS FRYDENDAL
IPC: A61M5/315
Filed: 1991-09-20
Abstract: A closure for the outlet end of an ampoule having a neck with an outwardly extending annular projection (30), said closure comprising a holding cap (18;61) with a skirt (35;62) with interior protrusions (38) for engagement behind the annular projection (30) of the neck, which holding cap engages a disc shape part (31) to press it sealingly against the annular projection (30). A locking ring (20;64) on the outer side of the skirt (35;62) locks projections (38) in their engagement position behind the annular projection (30). Resilient fingers (37;65) and recesses (36;66) are provided on either the skirt or the locking ring, the recesses being positioned below the fingers so that the fingers may be pushed into the recesses when the locking ring is passed over the skirt. Either the skirt (35) or the locking ring (64), which part is not provided with the fingers and recesses, is provided with an edge over which the fingers may grip irreversibly when the locking ring is mounted in position on the skirt.
Patent AU-8687401-A (AU)
Title: Method and apparatus for mixing textile fibers and particulate materials
Inventor: FOSTER RAYMOND KEITH
IPC: D01G13/00
Filed: 2001-08-28
Abstract: Two dispersers tunnels (20, 22) are provided at a disperser station. Each disperser tunnel (20, 22) houses two dispersers (24, 26 and 28, 30). Each pair of dispersers (24, 26 and 38, 30) are spaced apart and confront each other, with a mixing zone (42, 54) being defined between them. A separate conveyor (32, 34, 36, 38) is provided for feeding textile fiber modules, e.g. cotton boll modules (18, 18', 18'', 18'''), to the dispersers (24, 26, 28, 30). Each pair of dispersers (24, 26) removes fiber clumps from the leading ends of the modules (18, 18', 18'', 18''') and dispenses them into the mixing zone (42, 54) in admixture with the fiber clumps from the other disperser (24, 26, 28, 30) of the pair. The blend or mixture of fiber clumps is collected in the upper run (50) of a conveyor (52) that serves to carry the fiber clumps away from the disperser station. The feed rate of the modules (18, 18', 18'', 18''') may be regulated and varied by regulating and varying the speed rates of the conveyors (32, 34, 36, 38). The feed conveyors may be provided with sidewalls so as to define storage bins. Bodies of particulate material may be stored in the storage bins and feed to the dispersers by use of the feed conveyors. The dispersers can be operated to dispense particles from the bodies of particulate material into the mixing zone, in admixture with particles of the other disperse of the pair. The feed rate of the conveyors can be varied for varying the feed rate of particulate material to the dispersers.