baber/WOPTO huggingface dataset:
Patent CA-2949972-A1 (CA)
Inventor: HOITINK RYAN
IPC: A61B18/14
Filed: 2016-11-29
Abstract: This disclosure is directed to a catheter having a dual node multiray electrode assembly at the distal end of the catheter body. The dual node multiray electrode assembly includes a proximal multiray array with a plurality of spines connected at one end, each spine having at least one ablation electrode, and a distal node. The dual node multiray electrode assembly may have an expanded configuration and a collapsed configuration wherein the spines are arranged generally along a longitudinal axis of the catheter body. The distal node may be configured to be deployed within a vessel and the proximal multiray array may be configured to engage tissue forming an ostium of the vessel with the ablation electrodes. In some embodiments, the relative distance between the proximal multiray array and the distal node is adjustable.
Patent CA-2951427-A1 (CA)
Title: Treatment for chronic lymphocytic leukemia (cll)
Inventor: FOSTER PAUL
IPC: A61K39/395
Filed: 2015-06-15
Abstract: The present disclosure relates to the treatment of chronic lymphocytic leukemia. Monoclonal antibody XmAb5574 is efficacious when administered to patient at certain dosage regimens. Further disclosed are regimens including said antibody is administered at least once weekly over at least eight weeks; or/and said antibody is administered at a level that achieves a total exposure to said patient measured by area under the curve (AUG) of 14,500 ug *day/ml or more.
Patent CA-2952652-A1 (CA)
Inventor: Elbibary Mohamed
IPC: B64D33/08
Filed: 2016-12-22
Abstract: A gas turbine engine cooling system (400,500,600) includes a gas turbine engine (100).  The gas turbine engine includes a core engine (102), a cold sink (602,202,316,302,702), a core undercowl space (131), and a core cowl (130) at least partially surrounding the core engine and defining a radially outer wall of the core undercowl space. The gas turbine engine cooling system includes an undercowl component (402) positioned in the core undercowl space. The gas turbine engine cooling system also includes a heat pipe (414) including a first end (416), a second end (418), and a conduit (420) extending therebetween.  The first end is thermally coupled to the undercowl component, and the second end is thermally coupled to the cold sink. The heat pipe facilitates transfer of a quantity of heat from the undercowl component to the cold sink.
Patent CA-2953452-A1 (CA)
Inventor: LIU ZUIFANG
IPC: G01N27/416
Filed: 2015-07-08
Abstract: A method of determining analyte concentration uses a redox reaction in an electrochemical cell that has at least two electrodes, one of which is a working electrode, at least one electrode being exposed to at least one redox mediator. The method uses at least one cycle of pulses, each cycle having at least a first potential and a second potential. The method comprises applying a first potential to initiate an accumulation phase that forces accumulation of a mediator concentration gradient at or close to the working electrode with a concentration that decreases towards the bulk solution, applying a second potential to initiate a measurement phase and deplete the established mediator concentration gradient at the working electrode, measuring current associated with the second potential of each cycle, and using the measured current to determine analyte concentration. In this way, the effects of diffusion interfering factors (DIF), especially haematocrit (Hct) can be mitigated.
Patent CA-2954991-A1 (CA)
Inventor: JIANG QIAN
IPC: G10L15/22
Filed: 2017-01-11
Abstract: Systems and methods for contacting emergency personnel via voice recognition are provided. Some methods include detecting and identifying, via voice recognition, a first predetermined phrase, determining whether a second predetermined phrase is detected and identified, via voice recognition, within a predetermined period of time after detection and identification of the first predetermined phrase, and when the second predetermined phrase is detected and identified within the predetermined period of time, contacting emergency personnel.
Patent CA-2958053-A1 (CA)
Title: Hydrogels de trehalose pour la stabilisation et l'administration de proteines
Inventor: MAYNARD HEATHER D
IPC: A61K47/34
Filed: 2015-08-12
Abstract: L'invention concerne des hydrogels à base de tréhalose et des procédés de fabrication de ces hydrogels. De manière spécifique, l'invention concerne un procédé de production d'un hydrogel à base de tréhalose, comprenant les étapes consistant à : a) former un homopolymère ou un copolymère de tréhalose ; b) préparer un agent de réticulation; et c) faire réagir l'homopolymère ou le copolymère de tréhalose avec l'agent de réticulation pour former l'hydrogel à base de tréhalose.
Patent CA-2958168-A1 (CA)
Title: Dispositifs epidermiques pour l'analyse de la temperature et de caracteristiques de transport thermique
Inventor: ROGERS JOHN A
IPC: A61B5/01
Filed: 2015-08-11
Abstract: L'invention concerne des dispositifs montés sur un tissu et des procédés permettant de surveiller une propriété de transport thermique (par exemple, la conductivité thermique, la diffusivité thermique, la capacité calorifique) d'un tissu, comme la peau. Les dispositifs se montent en se conformant au tissu et comprennent un ou plusieurs actionneurs thermiques et une pluralité de capteurs. L'actionneur applique de la chaleur au tissu et les capteurs détectent une distribution spatiotemporelle d'un paramètre physiologique du tissu ou d'une propriété physique résultant du chauffage. Cette information spatiotemporelle peut être corrélée avec un débit, une vélocité et/ou une direction du flux sanguin, la présence d'une occlusion vasculaire, des changements dans la circulation dus à l'inflammation, le niveau d'hydratation et d'autres paramètres physiologiques.
Patent CA-2958205-A1 (CA)
Inventor: PARENTO STEPHEN A
IPC: G06Q40/00
Filed: 2015-07-24
Abstract: A method includes storing payroll information for an employee of an employer. The payroll information may include the employee's name, address, electronic contact information, etc. A payroll service computer may receive an indication from an employer that the computer is to make a payroll disbursement to the employee. The computer may present disbursement options to the employee. The employee may select one of the disbursement options. The computer may initiate the payroll disbursement in accordance with the option selected by the employee.
Patent CA-2958612-A1 (CA)
Inventor: LAMBERT TONY A
IPC: F02C9/18
Filed: 2017-02-22
Abstract: A gas turbine engine includes devices, systems, and methods for providing bleed air from the compressor impeller to the turbine for cooling and/or other use. The bleed air may include compressor cooling air that is routed through the diffuser and external to an outer bypass duct and/or internally to a forward wheel cavity of the turbine.
Patent CA-2958683-A1 (CA)
Inventor: MCCORMICK FRANK
IPC: A61K45/06
Filed: 2015-09-10
Abstract: The present invention provides method of treating a K-Ras-expressing cancer in a subject comprising administering to the subject a therapeutic amount of prostratin or a prostratin analog, or a salt or isomer thereof. Compositions and kits for treating a K-Rasexpressing cancer in a subject are also provided.
Patent CA-2959194-A1 (CA)
Title: 4-substituted-2-(n-(5-substituted allyl amide)phenyl)amino)pyrimidine compound, its use as an egfr inhibitor, and preparation and application thereof
Inventor: WEI MINGSONG
IPC: C07D491/10
Filed: 2015-09-30
Abstract: A 4-substituted-2-(N-(5-substituted allyl amide)phenyl)amino)pyrimidine derivative as represented by formula (I), and a preparation and application thereof as an EGFR inhibitor. The compound has activity of inhibiting the L858R EGFR mutant, the T790M EGFR mutant and the exon 19 deletion activating mutant, may be used to treat diseases mediated alone or in part by EGFR mutant activity, and has a wide application in drugs preventing and treating cancers, particularly non-small cell lung cancer.
Patent CA-2959377-A1 (CA)
Title: Particle detection
Inventor: KNOX RON
IPC: G08B17/103
Filed: 2009-06-10
Abstract: A particle detection system 600 including; at least one light source (606) adapted to illuminate a volume being monitored (610) at at least two wavelengths; a receiver (604) having a field of view (620) and being adapted to receive light from at least one light source (606, 607) after said light has traversed the volume being monitored and being adapted to generate signals indicative of the intensity of light received at regions within the field of view of the receiver; a processor (624) associated with the receiver (604) adapted to process the signals generated by the receiver to correlate light received at at least two wavelengths in corresponding regions within the field of view of the receiver and generate an output indicative of the relative level of light received at the two wavelengths.
Patent CA-2960393-A1 (CA)
Title: Vent operator
Inventor: MCINNIS JAMES
IPC: E05F11/10
Filed: 2015-09-08
Abstract: An operator assembly may move a window vent relative to a frame. The operator assembly includes a stationary member, an arm and a drive member. The arm is mounted for rotation relative to the stationary member between an open position and a closed position. The drive member is received in a channel defined by the stationary member for linear motion therein relative to the stationary member and the arm among a first position in which the drive member engages a locking feature of the window vent, a second position in which the drive member is spaced apart from and disengaged from the locking feature without rotating the arm out of the closed position, and a third position in which the drive member is further spaced apart from the locking feature. Movement of the drive member between the second and third positions moves the arm between the closed and open positions.
Patent CA-2962725-A1 (CA)
Inventor: BHARATE SANDIP
IPC: C07C49/753
Filed: 2015-07-20
Abstract: The present invention relates to the polyprenylated phloroglucinol compounds of formulae I and II. The present invention also provides synthesis and p-glycoprotein induction activity of the alkyl- and acyl- polyprenylated phloroglucinol compounds. Further, use of the compounds as p-glycoprotein inducers and methods of treatment of Alzheimer's disease using compounds of the invention are also provided.
Patent CA-2964504-A1 (CA)
Title: Forme de dose orale comprenant un derive de cyclopropanecarboxamide pourutilisation dans le traitement de l'insomnie
Inventor: MOLINE MARGARET
IPC: A61K31/506
Filed: 2015-10-21
Abstract: Selon la présente invention, des composés tels que le (1R,2S)-2-(((2,4-diméthylpyrimidin-5-yl)oxy)méthyl)-2-(3-fluorophényl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide se sont révélés être de puissants antagonistes des récepteurs de l'orexine, et peuvent être utiles pour le traitement de troubles du sommeil, tels que l'insomnie, ainsi que pour d'autres utilisations thérapeutiques.
Patent CA-2968173-A1 (CA)
Inventor: YANG LI-FEN
IPC: A47K1/14
Filed: 2017-05-25
Abstract: A sink drain stopper includes body which has a disk and a connection portion respectively formed on two ends thereof. The stopper is moved relative to the drain hole of a sink by a linkage unit. The disk is cooperated with a seal ring to seal the drain hole of a sink. The connection portion includes at least two holes which are spaced apart from each other. A cover plate has a recess in the underside thereof, and the disk is engaged with the recess. A board extends perpendicularly from the connection portion and includes multiple apertures which are located alternatively relative to the holes. The holes and the apertures are located at different heights and positions so as to be cooperated with the linkage unit such that the sink drain stopper can be used with the different sizes of sinks.
Patent CA-2969507-A1 (CA)
Inventor: WALLACE BRIAN A
IPC: F16J15/3252
Filed: 2017-06-02
Abstract: A bonded seal includes a rigid annular carrier having an annular recess therein.  An elastomer seal member is bonded within the annular recess. A thermoplastic backup ring is bonded to the elastomer seal member and disposed at an axial end of the annular recess and including elastomer material disposed between at least a portion of an outer diameter surface of the thermoplastic backup ring and the rigid annular carrier.
Patent CA-2970241-A1 (CA)
Title: Ensemble engrenage en ciseaux dote d'un mecanisme d'isolation integre
Inventor: SEFCIK MICHAEL C
IPC: F16H55/18
Filed: 2015-12-11
Abstract: Ensemble engrenage d'entraînement entraînant en rotation un engrenage entraîné d'un composant de moteur. L'ensemble engrenage d'entraînement comprend un arbre d'entraînement s'étendant longitudinalement le long d'un axe. Un engrenage d'entraînement principal est fonctionnement accouplé à l'arbre d'entraînement et un engrenage en ciseaux est aligné de manière coaxiale avec l'engrenage d'entraînement principal. Un ressort de ciseaux est disposé et fonctionnellement accouplé entre l'engrenage principal d'entraînement et l'engrenage en ciseaux et sollicité entre ceux-ci, l'engrenage principal d'entraînement et l'engrenage en ciseaux tournant autour de l'axe l'un par rapport à l'autre. Un mécanisme d'isolation est fonctionnellement accouplé entre l'engrenage d'entraînement principal et l'arbre d'entraînement pour l'absorption de charges d'impulsion produites par l'engrenage entraîné lorsqu'il est en prise avec l'engrenage principal d'entraînement.
Patent CA-2970977-A1 (CA)
Inventor: BLEIEL SINEAD
IPC: A61K9/50
Filed: 2015-12-15
Abstract: A cold-gelated mono-nuclear microencapsulate comprises a unitary liquid core encapsulated within a gastro-resistant, ileal-sensitive, polymerized denatured protein membrane shell, wherein the liquid core comprises a GLP-1 release stimulating agent in a substantially solubilised form. The GLP-1 release stimulating agent is a native protein selected from native dairy protein, native vegetable protein or native egg protein.
Patent CA-2971145-A1 (CA)
Inventor: CAIMI LUIGI
IPC: H01B7/02
Filed: 2014-12-17
Abstract: Energy cable comprising, from the interior to the exterior, an electrical conductor, an inner semiconductive layer, an electrically insulating layer made from a thermoplastic material in admixture with a dielectric fluid, and an outer semiconductive layer, wherein the outer semiconductive layer comprises: (i) from 55 wt% to 90 wt% of a copolymer of ethylene with at least one ester comonomer having an ethylenic unsaturation; (ii) from 10 wt% to 45 wt% of a propylene copolymer with at least one olefin comonomer selected from ethylene and an a-olefin other than propylene, said copolymer having a melting point of from 145°C to 170°C and a melting enthalpy of from 40 J/g to 80 J/g; (iii) at least one conductive filler; (iv) at least one dielectric fluid; the amounts of (i) and (ii) being expressed with respect to the total weight of the polymeric components of the layer. The outer semiconductive layer is cold-strippable, having an adhesion with the underlying thermoplastic insulating layer which can be tuned so as to obtain a suitable balance between strippability at a temperature ranging from about 0°C to about 40°C, without applying heat, and stable adhesion with the insulating layer during the cable lifespan.
Patent CA-2972537-A1 (CA)
Inventor: MATEI JIM
IPC: F01K23/02
Filed: 2017-07-07
Abstract: An ocean powered Rankine cycle turbine includes a loop in which is circulated a working fluid. A first heat exchanger effects a phase change of the working fluid from liquid to gas. The gas expands to power a turbine. Gas exiting the turbine is condensed by a second heat exchanger to effect a phase change from gas back to liquid. A piston assembly is used to compress air. A wave energy converter uses ocean wave energy to reciprocally move the piston. As the wave goes down, the piston is extends drawing air into the piston housing. As the wave goes up, the piston compresses the air. Heat generated as the piston compresses air, is used to as a heat source for the first heat exchanger. Cold compressed air is used as a cold source for the second heat exchanger.
Patent CA-2973202-A1 (CA)
Inventor: MERTZ ERIC
IPC: A61K31/4375
Filed: 2016-01-15
Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Patent CA-2973327-A1 (CA)
Title: Embolization microcatheter
Inventor: TAL MICHAEL GABRIEL
IPC: A61M25/00
Filed: 2016-01-08
Abstract: Microcatheter for delivering a substance (e.g., infusion agent including embolization material and/or contrast enhancing material) in a small blood vessel towards a target bodily part. Includes a single lumen surrounded by tubular wall having outer diameter and opened at both ends; tubular wall proximal portion is connectable to a pressure source and reservoir containing infusion agent, and tubular wall distal portion ends with a tip; the tubular wall distal portion includes an infusion agent flow disruption section configured to disrupt passage therethrough of incoming retrograded flow of infusion agent, during continuous delivery of infusion suspension from the reservoir to the tip. Disclosed are methods using the microcatheter for performing local embolization in a small blood vessel feeding a (for example, cancerous) target bodily part, and for delivering infusion agent in a small blood vessel towards such target bodily part.  Also disclosed are devices and methods for filtering non-target infusion agent.
Patent CA-2974067-A1 (CA)
Inventor: TAKASHITA TAKUYA
IPC: H01F1/20
Filed: 2016-02-08
Abstract: Soft magnetic powder for dust cores that yields dust cores having low eddy current loss is provided. Raw material powder for soft magnetic powder comprises Fe: 60 mass% or more, a .gamma.-phase stabilizing element, and an electric resistance-increasing element: 1.0 mass% or more.
Patent CA-2974958-A1 (CA)
Inventor: BENNETT ANTON
IPC: A61K31/00
Filed: 2016-01-26
Abstract: La présente invention concerne des compositions et des procédés d'inhibition de phosphorylation de tyrosine. Dans un aspect, une composition comprend un inhibiteur de tyrosine kinase à faible dose, l'inhibiteur de tyrosine kinase à faible dose diminuant la phosphorylation de tyrosine. Dans un autre aspect, l'invention concerne un procédé pour traiter une maladie cardiovasculaire ou un état associé à RASopathie ayant la phosphorylation de tyrosine de protéine aberrante. L'invention concerne également des procédés pour traiter une maladie cardiaque congénitale associée à Noonan ou un syndrome de Noonan avec de multiples lentigines, et diminuer des niveaux aberrants de phosphorylation de tyrosyle de protéine associée à 0 (PZR).
Patent CA-2975388-A1 (CA)
Title: Stabilizing sorbic acid in beverage syrup
Inventor: MUTILANGI WILLIAM
IPC: A23L2/52
Filed: 2016-02-18
Abstract: A method for preparing a sorbate powder comprising dissolving sorbate salt in water, adding a stabilizing carrier to the sorbate solution, and spray drying the sorbate solution to form the sorbate powder. The sorbate powder is stable in beverage syrup.
Patent CA-2976731-A1 (CA)
Inventor: LU LIMENG
IPC: F25C5/04
Filed: 2016-07-22
Abstract: The present invention discloses an impact ice driller, which comprises a frame (1); a motor (2); a rotatable drill stem (7); a stationary element and a rotatable element disposed along a same axis and facing each other; characterized in that, the stationary element is connected to the frame (1); the rotatable element is connected to the drill stem (7) and synchronously moves with the drill stem (7) as driven by the motor (2); the stationary element and the rotatable element each has an irregular surface capable of engaging with each other on each opposite surface, when the rotatable element rotates, the irregular surface of the stationary element and the irregular surface of the rotatable element can repeat engagement and separation, so that the rotatable element can repeat the movement along an axis relative to the stationary element. In this way, the drill stem can produce up-and-down impacts on ice cover ceaselessly in the ice drilling process with good ice drilling effect.
Patent CA-2980462-A1 (CA)
Title: Immunoconjugues de nanoparticules
Inventor: YOO BARNEY
IPC: A61P35/00
Filed: 2016-04-07
Abstract: La présente invention concerne des immunoconjugués de nanoparticules utiles pour des thérapies et/ou des diagnostics. Les immunoconjugués possèdent un diamètre (par exemple, un diamètre moyen) qui n'est pas supérieur à 20 nanomètres (par exemple, tel que mesuré par diffusion de lumière dynamique ou DLS dans une solution aqueuse, par exemple une solution saline). Dans certains modes de réalisation, les conjugués sont des nanoparticules à base de silice avec des fragments d'anticorps à chaîne unique fixés à ceux-ci.
Patent CA-2981890-A1 (CA)
Inventor: BRANDES RONALD
IPC: G01N37/00
Filed: 2017-10-10
Abstract: In a method for testing the disinfecting activity of at least one disinfectant it is provided that at least one sample of the disinfectant is measured with a sensor in regard to a change in at least one physical and/or chemical property of the disinfectant.
Patent CA-2982106-A1 (CA)
Title: Dental amalgam separation and recycling system
Inventor: MOZZICATA NICHOLAS
IPC: A61C17/00
Filed: 2017-10-12
Abstract: The present invention provides dental amalgam separation and collection systems combining features that significantly reduces the occurrence of leaks and spills that can result from the improper insertion or removal of a detachable collection container. The detachable collection container comprises an effluent inlet port and effluent outlet port projecting from its top surface, and keyways cast into its outside top mating surface, and connects to an air-water separation tank having a mating surface with keys cast into its mating surface; such that the air-water separation tank and collection container must be aligned to match up the keys and keyways in order for the collection container to be securely inserted into or detached from the dental amalgam separation system.
Patent CA-2985646-A1 (CA)
Inventor: HINDLE WILLIAM A
IPC: G01R31/00
Filed: 2016-05-11
Abstract: Disclosed herein are a monitoring system and a method for monitoring and reporting an aggregate system status of a DC subsystem and a battery charger. The monitoring system comprises at least one monitoring-enabled module; an aggregator being in electrical communication with each of the at least one monitoring-enabled module; and an aggregate health status indicator in electrical contact with the aggregator.
Patent CA-2988482-A1 (CA)
Inventor: CAPUZZI LUIGI
IPC: C09K5/10
Filed: 2016-06-10
Abstract: The present invention relates to polyol esters that are particularly suitable for use as insulating oils in electrical equipment where an effective cooling action is required, such as electrical transformers. In particular the invention relates to esters of trimethylolpropane with monocarboxylic acids of nine and /or ten carbon atoms, wherein the monocarboxylic acids of nine and/or ten carbon atoms comprise 5-15 mol % of branched acids and 85-95 mol % of linear acids with respect to the total moles of the monocarboxylic acids.
Patent CA-2990471-A1 (CA)
Title: 4-(3-pyrazolylamino)-benzimidazole compounds and their use as jak1 inhibitors
Inventor: CLAYTON JOSHUA RYAN
IPC: C07D403/12
Filed: 2016-07-28
Abstract: The present invention relates to certain benzimidazole compounds of Formula I, or pharmaceutically acceptable salts thereof, that inhibit Janus kinase 1 (JAKI), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat certain types of cancer.