Patent SG-11201810389X-A (SG)
Title: New antibacterial compounds
Inventor: OMBRATO ROSELLA
IPC: A61K31/4985
Filed: 2017-06-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111H1111111111111111111111111111111111113111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/211760 Al 14 December 2017 (14.12.2017) WIP0 I PCT (51) International Patent Classification: vembre, 18, 00072 Ariccia (RM) (IT). GAROFALO, Bar- CO7D 471/04 (2006.01) CO7D 493/04 (2006.01) bara; Via Latina, 49, 00179 ROMA (IT). FURLOTTI, CO7D 491/04 (2006.01) A61K 31/4985 (2006.01) Guido; Via Ferdinando Palasciano, 96, 00151 ROMA (IT). C07D 401/14 (2006.01) A61K 31/436 (2006.01) MANGANO, Giorgina; Via Gran Paradiso, 84, 00139 RO- 007D 498/04 (2006.01) A61P 31/04 (2006.01) MA (IT). CAPEZZONE DE JOANNON, Alessandra; Pi- CO7D 513/04 (2006.01) azza dei Vespri Siciliani, 7, 00161 ROMA (IT). (21) International Application Number: (74) Agent: COLOMBO, Stefano, Paolo et al.; MARCHI & PCT/EP2017/063601 PARTNERS S.r.1., Via Vittor Pisani, 13, 20124 Milano (22) International Filing Date: (IT). 05 June 2017 (05.06.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, 16173550.1 08 June 2016 (08.06.2016) EP KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, — (71) Applicant: AZIENDE CHIMICHE RIUNITE AN- MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, GELINI FRANCESCO A.C.R.A.F. S.P.A. [IT/IT]; Viale PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, Amelia, 70, 00181 ROMA (IT). SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. — (72) Inventors: OMBRATO, Rosella; Via Abigaille Zanetta, 68, 00143 ROMA (IT). MAGARO, Gabriele; Via IV No- = _ Title: NEW ANTIBACTERIAL COMPOUNDS (54) = .------' — — • ., -..... = — N.. o ,s „. , G, = = = = (I) (0) (III) = = H 3 = = 4 = R5 R2 = = (IV) (V) (VI) NH NH \" N ,... Il ,tD G8 IN 1-1 (VII) (VIII) (IX) 1-1 ei ---- (57) : The present invention relates to novel antibacterial compounds (1) as defined below, pharmaceutical compositions IN , 1 containing them and their use as antimicrobials. A compound of formula (1): A-L1-Y-L2-R-B, wherein A is a cyclic group having one 0 of ei the following formulae (I), (II) and (III), and wherein B is cyclic group having one of the following formulae (IV) to (IX). O [Continued on next page] WO 2017/211760 Al MIDEDIM11110111111111111111111111111111111111111111111111111101101111111111111111111 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))