baber/WOPTO huggingface dataset:
Patent CA-2660289-A1 (CA)
Inventor: KAUL GOLDI
IPC: A61K47/48
Filed: 2007-06-20
Abstract: Polymer particles including a covalently bonded chemical species, as well as related compositions and methods are disclosed. In one aspect, the invention features a particle that includes a polymer a chemical species covalently bonded to the polymer. The polymer includes vinyl alcohol monomer units, and the chemical species is selected from polymers, oligomers and monomers. The particle has a maximum dimension of 5,000 microns or less. In another aspect, the invention features a particle that includes a polymer, a chemical species covalently bonded to the polymer and a therapeutic agent. The polymer includes at least five weight percent vinyl alcohol monomer units and at least five weight percent vinyl formal monomer units. The chemical species is selected from polymers, oligomers and monomers and the particle has a maximum dimension of 5,000 microns or less.
Patent CA-2660814-A1 (CA)
Inventor: XU LINA
IPC: C07D209/82
Filed: 2006-08-15
Abstract: The novel positively charged pro-drugs of aryl- and heteroarylpropionic acids in the general formula (1) 'Structure 1' and general formula (2) 'Structure 2' were designed and synthesized. The compounds of the general formula (1) 'Structure 1' and general formula (2) 'Structure 2' indicated above can be prepared from functional derivatives of naproxen, suprofen, .alpha.- methyl-(p-chlorobenzoyl)-5-methoxy-2-methylindole 3-acetic acid, flurbiprofen, carprofen, pranoprofen, benoxaprofen, alminoprofen, tiaprofenic acid, pirprofen, zaltoprofen, bermoprofen, loxoprofen, indoprofen, fenclorac, oxaprozin, fenbufen, orpanoxin, ketorolac, clidanac, and related compounds, (for example acid halides or mixed anhydrides), by reaction with suitable alcohols, thiols, or amines. The positively charged amino groups of these pro-drugs not only largely increases the solubility of the drugs, but also bonds to the negative charge on the phosphate head group of membranes and pushes the pro-drug into the cytosol. The results suggest that the pro-drugs diffuses through human skin -100-130 times faster than do their parent drugs. It takes 2-4 hours for naproxen, suprofen, .alpha.- methyl-(p-chlorobenzoyl)-5-methoxy-2-methylindole 3-acetic acid, flurbiprofen, carprofen, pranoprofen, benoxaprofen, alminoprofen, tiaprofenic acid, pirprofen, zaltoprofen, bermoprofen, loxoprofen, indoprofen, fenclorac, oxaprozin, fenbufen, orpanoxin, ketorolac, clidanac, and related compounds to reach the peak plasma level when they are taken orally, but these prodrugs only took about 40-50 minutes to reach the peak plasma level when they are taken transdermally. In plasma, more than 90% of these pro-drugs can change back to the drug in a few minutes. The prodrugs can be used medicinally in treating any NS AIAs-treatable conditions in humans or animals. The prodrugs can be administered not only orally, but also transdermally for any kind of medical treatments and avoid most of the side effects of NSAIAs, most notably GI disturbances such as dyspepsia, gastroduodenal bleeding, gastric ulcerations, and gastritis. Controlled transdermal administration systems of the prodrugs enable naproxen, suprofen, .alpha.- methyl-(p-chlorobenzoyl)-5-methoxy-2-methylindole 3-acetic acid, flurbiprofen, carprofen, pranoprofen, benoxaprofen, alminoprofen, tiaprofenic acid, pirprofen, zaltoprofen, bermoprofen, loxoprofen, indoprofen, fenclorac, oxaprozin, fenbufen, orpanoxin, ketorolac, clidanac, and related compounds to reach constantly optimal therapeutic blood levels to increase effectiveness and reduce the side effects of NSAIAs. Another great benefit of transdermal administration of these pro-drugs is that administering medication, especially to children, will be much easier.
Patent CA-2661659-A1 (CA)
Inventor: JOUVIN MARIE-HELENE
IPC: C12N15/10
Filed: 2007-08-22
Abstract: Humanized monoclonal antibodies against the vaccinia virus B5R surface antigen. The antibodies are effective in treating smallpox infection. Also disclosed are nucleic acids that encode the heavy and light chains of such antibodies and cells that express them.
Patent CA-2666207-A1 (CA)
Inventor: NORRELL STEPHANIE
IPC: A61B5/15
Filed: 2007-10-15
Abstract: A device (1410) for collecting a blood sample from an animal on sampling media placed (1456) next to the animal's flesh, the device comprising holding means () for holding the sampling media (1456) for placement on the flesh of an animal; spike means (1418) operable to first pass through the sampling media (1456) and to then penetrate into the flesh of the animal to create a puncture site to allow blood emerging from the site to be collected by the sampling media (1456) during and/or after penetration of the flesh, and retaining means (1427) for temporarily retaining the device (1410) on the animal whilst blood is collected on the sampling media and for allowing the device (1410) to be removed from the animal substantially intact for subsequent removal of the sampling media (1456) with the blood from the device.
Patent CA-2667431-A1 (CA)
Title: Method and system for enhanced check image privacy
Inventor: LEE CLARENCE E II
IPC: G06K9/00
Filed: 2007-10-25
Abstract: A method and system for enhanced check image privacy are disclosed. Embodiments of the present invention provide a way to automatically link the results from quality assurance software to a check image archive to appropriately mark images as unretrievable by customers. Images are interrogated with a data matching algorithm to determine whether a confidence score expressing a likelihood that the image matches associated, stored magnetic ink character recognition (MICR) data is below a pre-set threshold. The image can be then automatically designated in the financial document archive. The image can be displayed to an operator for analysis when the confidence score is above the pre-set threshold and below a pre-set limit, or in cases where the confidence score cannot be determined by the data matching algorithm.
Patent CA-2671778-A1 (CA)
Title: Immediate release dosage form of bosentan and process of manufacturing such
Inventor: PATHAK VINAYAK
IPC: A61K9/20
Filed: 2009-07-10
Abstract: The present invention provides an immediate release oral pharmaceutical dosage form of a high dose poorly soluble active ingredient, wherein the in vitro dissolution rate of the said dosage form provides at least 90% of the active ingredient dissolved within 30 minutes as measured by USP Paddle Method at 50 rpm at 900 ml of dissolution buffer with 1% SDS at 37°C; and a process for manufacturing the said dosage form.
Patent CA-2671856-A1 (CA)
Inventor: CEDILOTE MIALL
IPC: C07D317/24
Filed: 2007-12-11
Abstract: The present invention provides a novel process for the preparation of 3,5-di-O- acyl-2-fluoro-2-C-methyl-D-ribono-g-lactone derivatives of formula (2) which are key intermediates in the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-.beta.-D-ribofuranosyl)cytosine (formula (1)) a compound that possesses potent and selective anti-hepatitis C virus activity.
Patent CA-2673539-A1 (CA)
Title: Fluidized spray drying
Inventor: BITTORF KEVIN JOHN
IPC: A61K38/05
Filed: 2007-12-26
Abstract: Methods of fluidized spray drying VX-950 are described.
Patent CA-2680177-A1 (CA)
Inventor: GEGE CHRISTIAN
IPC: C07D417/12
Filed: 2008-03-07
Abstract: The present invention relates generally..to heterocyclic metalloprotease inhibiting compounds of formula (I). More particularly, the present invention provides a new class of heterocyclic MMP 3, MMP 8 and/or MMP 13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP 13, MMP 8 and MMP 3 inhibitors.
Patent CA-2681467-A1 (CA)
Title: Roller blade guard assembly
Inventor: STEINHAUSER PAUL M JR
IPC: A63C17/18
Filed: 2007-03-16
Abstract: A roller blade guard assembly releasibly mountable over an ice skate blade attached to a boot by a blade mount. The roller blade guard assembly includes a blade guard having an open ended channel for receiving a skate ice blade. The blade guard extends a length along the channel. The roller blade guard assembly also includes a plurality of apertures extending transversely to the length in a longitudinally spaced manner along the length of the blade guard. The roller blade guard assembly also includes pairs of wheel assemblies, each having an axle mountable through one of the apertures in the blade guard. The roller blade guard assembly also includes a heel strap formed of elastic material for maintaining the blade guard on the blade. The heel strap includes a portion receivable in one of the apertures such that either one of the wheel assemblies or the heel strap is receivable in any one of the plurality of apertures.
Patent CA-2683797-A1 (CA)
Inventor: KAMPINGA HARM HARMANNUS
IPC: A61K31/568
Filed: 2008-04-14
Abstract: The invention provides a use of a substance that is capable of enhancing the amount and/or activity of DnaJB8, or a functional part, derivative and/or analogue thereof, for counteracting protein aggregation.
Patent CA-2685362-A1 (CA)
Inventor: ARONCHICK CRAIG A
IPC: A61K47/30
Filed: 2008-04-25
Abstract: Compositions of domperidone formulated for transmucosal delivery are provided. Also provided are methods for the treatment of nausea, vomiting, and gastrointestinal motility disorders, and methods for the enhancement of breast milk production. The methods utilize domperidone compositions formulated for transmucosal administration, administered to patients in an amount effective to treat nausea, vomiting, or gastrointestinal motility disorders, or to enhance breast milk production.
Patent CA-2686686-A1 (CA)
Title: Il-9 in fibrotic and inflammatory disease
Inventor: REED JENNIFER
IPC: A61P1/00
Filed: 2008-05-19
Abstract: The present invention encompasses methods of employing inhibitors of IL-9 in the treatment of fibrotic disorders, e.g., COPD and inflammatory bowel disease.
Patent CA-2688224-A1 (CA)
Inventor: MELIC JONNY JONATHAN
IPC: F16B7/08
Filed: 2007-02-22
Abstract: A clamp for securement to a cylindrical body such as scaffold tubing has first and second curved body portions hinged to each other to form a generally circular enclosure. A clasp for coupling the first and second curved body portions has a bolt fixed to one curved body portion and a rotatable housing. The housing has a peripheral groove to slidingly receive the bolt and is coupled to the other curved body portion. The housing has an access opening to receive the bolt into the peripheral groove and the bolt is captured in the peripheral groove when the housing is rotated. The housing is rotatable about a post which is fixed to the other curved body portion and has an opening to receive the post that is eccentric to the geometric center of the housing so that a passage formed between the peripheral groove and the post varies in width about the periphery of the housing. This variable width allows the housing to be tightened gradually on the bolt.
Patent CA-2688859-A1 (CA)
Inventor: GOERTZEN WILLIAM
IPC: C08J5/24
Filed: 2009-12-18
Abstract: An electric submersible pump (ESP) motor includes a polymer or ceramic component made by curing a thermosetting polymer in situ in the ESP motor, wherein the thermosetting polymer is selected from the group consisting of cyanate ester, bismaleimide, polyimide, benzoxazine, a preceramic polymer, and a mixture thereof, or the thermosetting polymer is a hybrid polymer having less than 50% by weight of an epoxy component and a second component selected from the group consisting of cyanate ester, bismaleimide, polyimide, benzoxazine, a preceramic polymer, and a mixture thereof.
Patent CA-2689400-A1 (CA)
Title: Appareil et procede d'administration d'agent therapeutique
Inventor: ADAMS KENNETH W
IPC: A61K9/08
Filed: 2009-12-30
Abstract: Il est décrit une méthode et un dispositif pour ladministration dun médicament formulé en liquide sur une pluralité de sites tissulaires adjacents dun mammifère. Le dispositif comprend, dune part, une pluralité déléments qui sont en contact avec les tissus de façon à recevoir le médicament et peuvent entrer fonctionnellement en contact avec la pluralité de sites tissulaires, et, dautre part, des organes servant, non seulement à alimenter avec cette formulation les éléments au contact des tissus, mais aussi à entretenir et réguler temporairement le débit, par unité de temps, de lagent thérapeutique, et de préférence à entretenir sur des durées prolongées ces débits dadministration régulés, de façon à renforcer leffet thérapeutique local de ces agents thérapeutiques, tout en réduisant la toxicité systémique ainsi que les effets secondaires indésirables.
Patent CA-2690569-A1 (CA)
Inventor: TREU MATTHIAS
IPC: A61P35/00
Filed: 2008-06-09
Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharma-ceutical composition having the above-mentioned properties.
Patent CA-2692474-A1 (CA)
Inventor: RAY EUGENE W
IPC: A47K10/32
Filed: 2010-02-09
Abstract: A wipes dispenser includes a container having an interior holding a plurality of wipes. A grip orifice provides communication between the interior and the exterior of the container, and the grip orifice serves to prevent wipes from falling back into the interior. The dispenser also includes a rip fence, and a lead end of a lead wipe of the plurality of wet wipes within the container extends through the grip orifice and then through the rip fence such that pulling on the lead end to pull the lead wipe against the rip fence causes the remainder of the lead wipe to be removed from the container and become disassociated with the remaining wipes of the plurality of wipes. As the lead end is pulled against the rip fence, the following wipe of the plurality of wipes is pulled through the grip orifice to provide its lead end outside of the interior of the container, and the grip orifice prevents this lead end of the following wipe from falling back into the interior of the container.
Patent CA-2693175-A1 (CA)
Inventor: VARNEY MARK
IPC: A61B5/083
Filed: 2007-07-20
Abstract: A sensor for sensing a target substance in a gas stream is provided, the sensor comprising: a sensing element disposed to be exposed to the gas stream, the sensing element comprising: a working electrode; a counter electrode; and a layer of ion exchange material extending between the working electrode and the counter electrode;  whereby contact of the ion exchange layer with the gas stream forms an electrical contact between the working and counter electrodes.
Patent CA-2693409-A1 (CA)
Inventor: ZIERHOFER CLEMENS M
IPC: A61F11/04
Filed: 2008-07-11
Abstract: A system and method of generating electrode stimulation signals for an implanted multi -channel electrode array of a cochlear implant includes processing an acoustic audio signal with a bank of filters. Each filter in the bank of filters is associated with at least one channel having an electrode. The bank of filters includes a first band pass filter that produces a broadband signal b(t) with frequencies that substantially cover at least one of a pitch frequency range of 100 Hz to 400 Hz and a first format range of 400 Hz - 1000 Hz. At least one electrode associated with the first band pass filter is activated with electrode stimulation signals based, at least in part, on the broadband signal b(t). The filter bank may include at least one electrode associated with one or more filters other than the first band pass filter, the one or more filters producing signals having only higher frequencies than broadband signal b(t).
Patent CA-2694064-A1 (CA)
Inventor: PATEL BHAWAN
IPC: F23R3/06
Filed: 2008-06-18
Abstract: A method of producing a plurality of effusion holes (22) in a wall (20) of a combustor (16) of a gas turbine engine (10) comprises: determining a hole pattern definition which provides a functional relationship of the spacing between each adjacent hole within the row of holes (22); using the hole pattern definition to identify individual positions of the effusion holes (22) to be produced; and using a hole producing system to produce the effusion holes (22) at the identified positions.
Patent CA-2694168-A1 (CA)
Inventor: XU HAO
IPC: H04L25/03
Filed: 2008-08-12
Abstract: Techniques for sending a MIMO transmission in a wireless communication system are described. In one design, a transmitter sends a first reference signal to a receiver. The receiver selects a precoding matrix based on the first reference signal and in accordance with a selection criterion. The receiver estimates noise and interference at the receiver and determines channel quality indicator (CQI) or modulation and coding scheme (MCS) information based on the precoding matrix and the estimated noise and interference. The receiver sends the CQI or MCS information and a second reference signal to the transmitter. The transmitter selects the precoding matrix based on the second reference signal and in accordance with the same selection criterion used by the receiver. The transmitter then  sends a MIMO transmission to the receiver based on the CQI or MCS information obtained from the receiver and the precoding matrix selected by the transmitter.
Patent CA-2694179-A1 (CA)
Inventor: BOSAN SOREL
IPC: H04M1/72436
Filed: 2010-02-23
Abstract: A method and system for delivery and display of a message on a communication device. A  dialed first digit of a multi-digit recipient phone number being called is received at the communication device. A message accessibly stored in memory is accessed, and display of the message is initiated on a display screen of the communication device. A call connection may be attempted with the recipient phone number. The call connection status is monitored, and a response indicative of the status may be generated to the communication device. In one embodiment, the message may be an advertisement message.
Patent CA-2698520-A1 (CA)
Inventor: ERIKSEN STEEN MANDSFELT
IPC: A47B9/08
Filed: 2008-07-18
Abstract: An assembling arrangement serves for securing a tubular furniture (1;17) leg (3) to the top plate (2;18) of a piece of furniture.  The assembling arrangement comprises a through opening (11) formed in the top plate (2; 18), a top mounting (5), which spans the through opening (11) on the top side of the top plate (2; 18), a bottom mounting (6), which spans the through opening (11) on the bottom side of the top plate (2; 18) and is attached to the leg (3), a first bore (10) formed through the top mounting (5) and a second bore (12) formed through the bottom mounting (6) in line with the first bore (10), a screw (7; 29) having a shaft (8; 30) extending downwards in the leg (3) via the first bore (10), the through opening (11) and the second bore (12), a nut (23;27) for the screw (7;29) shaft (8;30) placed in the leg (3), and an anchor means (9) serving for firmly anchoring the nut (23;27) in the leg (3) in the secured state of the leg (3). The assembling arrangement is non-expensive and strong and can advantageously be used for mounting legs upon cantilever tables and chairs.
Patent CA-2698740-A1 (CA)
Inventor: COHEN ISAAC
IPC: A61K36/70
Filed: 2008-09-05
Abstract: Extracts of various species of the Polygonaceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Rheum palmatum L of the Polygonaceae family species possess estrogenic properties in both ER.alpha.+ and ER.beta.+  cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression.  Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.
Patent CA-2699565-A1 (CA)
Inventor: PETERSON DAVID A
IPC: G06F13/14
Filed: 2008-09-19
Abstract: A computer system having a host computer and multiple terminals. The host computer (including any peripheral hubs or the like) has groups of at least three I/O ports (preferably USB  ports) where the I/O ports of a single group are supposed to be used to connect I/O devices associated with a single terminal. When connecting up a new terminal, after a user connects two I/O devices into a group and affirmatively indicates, by user input, that these belong to the same terminal, then further devices subsequently connected into the same group of I/O ports will be automatically assigned to the terminal previously indicated by the user. Also, a computer system where multiple operating systems are respectively used to control multiple displays. A video output module creates a master frame display including display data for (at least) the displays of all of the operating systems. The master frame display is split into portions respectively corresponding to each operating system.
Patent CA-2699721-A1 (CA)
Inventor: SMITH SCOTT R
IPC: G01R33/32
Filed: 2008-09-22
Abstract: Imaging a device in a magnetic resonance imaging system includes inserting a device having a conductive coil assembly thereon into a subject, obtaining a magnetic resonance image of the subject that includes signal phase variations, determining a position of the device based on discontinuities in the signal phase variations, and displaying an image representation of the device superimposed on a reference image based upon the determined position.
Patent CA-2700769-A1 (CA)
Inventor: CONSIGLIO NUNZIO
IPC: H05B3/28
Filed: 2010-04-16
Abstract: The present invention is a radiant heating tile system for installation on a supporting surface.  The system utilizes a plurality of modular heating tiles, the modular heating tiles each being substantially flat and having a substantially equal thickness. Each of the heating tiles have parallel top and bottom surfaces, a plurality of sides and an electrical heating element. The heating tiles each also have an insulator layer covering the bottom surface of the tile. The electrical heating element of each of the heating tiles is electrically coupled to a male electrical coupling contained in a notch formed on a first side of said tile. The electrical heating element of each of the heating tiles is also electrically coupled to a female electrical coupling contained in a notch formed on a second side of said tile opposite the first side. The male and female couplings are configured and the notches are positioned such that when two of said heating tiles are abutted together in side to side orientation, the male coupling of one heating tile is aligned with and can couple to the female coupling of the other tile.
Patent CA-2703294-A1 (CA)
Inventor: MERTENS JOHANN
IPC: G01N33/543
Filed: 2008-09-23
Abstract: The present invention refers to a method for detecting molecules and/or substances within a sample based on the use of a microcantilever system. The method comprises the variation of a certain condition such as humidity so as the mechanical feature analysed varies with a characteristic pattern while the target molecule is bound to the detector. The invention also refers to the system used to carry out such method.
Patent CA-2703761-A1 (CA)
Title: Ready to feed container with drinking dispenser and sealing member, and related method
Inventor: PY DANIEL
IPC: A61J11/00
Filed: 2008-10-27
Abstract: A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.