Patent SG-11201900853S-A (SG)
Title: Use of adamts13 for treating, ameliorating and/or preventing vaso-occlusive crisis in sickle cell disease, acute lung injury and/or acute respiratory distress syndrome
Inventor: EWENSTEIN BRUCE
IPC: A61P7/02
Filed: 2017-08-04
Abstract: PUBLISHEDUNDER THE PATENT COOPERATION TREATY (PCT) °Ens °nolo omoiolow om oimIE () International Publication Number WO 2018/027169 Al WIPO I PCT (12) INTERNATIONAL APPLICATION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) (51) International Patent Classification: A61K 38/48 (2006.01) A61P 7/02 (2006.01) (21) International Application Number: PCT/US2017/045573 (22) International Filing Date: 04 August 2017 (04.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/371,030 04 August 2016 (04.08.2016) US (71) Applicants: BAXALTA INCORPORATED [US/US]; 1200 Lakeside Drive, Bannockburn, IL 60015 (US). BAX- ALTA GMBH [CH/CH]; Zaehlerweg 4, 6300 Zug (CH). (72) Inventors: EWENSTEIN, Bruce; 15 Claflin Path, Brook- line, MA 02445 (US). GOLDSTEIN, Brahm; 26 2nd Street, TH2, Cambridge, MA 0241 (US). MAJER, Bern- hard; Colloredogasse 25A, 1180 Vienna (AT). ROSSA- TO, Paolo; Liechtensteinstrasse 3, 1090 Vienna (AT). SCHEIFLINGER, Friedrich; Michelbeuerngasse 4/17, 1090 Vienna (AT). TURECEK, Marietta; Frauenwald 2, 3001 Mauerbach (AT). (74) Agent: SULLIVAN, Nicole, R.; Troutman Sanders LLP, 875 Third Avenue, New York, NY 10022 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: USE OF ADAMTS13 FOR TREATING, AMELIORATING AND/OR PREVENTING VASO-OCCLUSWE CRISIS IN = SICKLE CELL DISEASE, ACUTE LUNG INJURY AND/OR ACUTE RESPIRATORY DISTRESS SYNDROME 100 80 AAAA\ AAAA AA vehide AA BAX 930 SCD vehicle SCD BAX 930 — 60 -82 40 20 AAAA 1-1 1-1 N C•1 O 00 O 1-1 C•1 C 0 5 7 10 13 Tme (hours) FIGURE 1 (57) : The disclosure provides compositions and methods for treating, ameliorating, and/or preventing a vaso-occlusive crisis (VOC) in a subject suffering from sickle cell disease (SCD). The disclosure also provides compositions and methods for treating, ameliorating, and/or preventing lung injury in a subject suffering from or at risk of suffering from acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). The disclosure provides A Disintegrin And Metalloproteinase with Thrombospondin type 1 motif, member- 13 (ADAMTS13) or a composition comprising ADAMTS13 for treating, ameliorating, and/or preventing the VOC, or for treating, ameliorating, and/or preventing lung injury in a subject suffering from or at risk of suffering from ALI and/or ARDS. [Continued on next page] WO 2018/027169 Al MIDEDIMOMMIDIIMERIONMOIDEEDHINIOMEHOIS SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))