baber/WOPTO huggingface dataset:
Patent SG-11201806496S-A (SG)
Title: Antigen binding proteins that bind pd-l1
Inventor: ZHOU HEYUE
IPC: C12P21/08
Filed: 2017-01-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization MD 1111101110101011111 HO 11111 0111011100101111101110101111111011 III International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/132562 Al 3 August 2017 (03.08.2017) WI P0 I P CT (51) International Patent Classification: C12P 21/08 (2006.01) A61K 39/00 (2006.01) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (21) International Application Number: PCT/US2017/015429 RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (22) International Filing Date: ZA, ZM, ZW. 27 January 2017 (27.01.2017) (84) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (26) Publication Language: English TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (30) Priority Data: 62/288,912 29 January 2016 (29.01.2016) US TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventor; and SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (71) Applicant : ZHOU, Heyue [CN/US]; 15732 Potomac GW, KM, ML, MR, NE, SN, TD, TG). Ridge Road, San Diego, CA 92127 (US). Published: (74) Agents: HERRITT, Danielle, L. et al.; McCarter & Eng- lish, LLP, 265 Franklin Street, Boston, MA 02110 (US). with international search report (Art. 21(3)) (81) Designated States (unless otherwise indicated, for every before the expiration of the time limit for amending the claims and to be republished in the event of receipt of kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, — DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) = 1-1 N kr) N M 11 IN 11 © (54) Title: ANTIGEN BINDING PROTEINS THAT BIND PD-L1 el 0 (57) : There is disclosed anti-PD-L1 IgG class antibodies that have an improved ability to be manufactured at higher yields. More specifically, there is disclosed human antibodies that bind PD -L1, PD-L1 -binding fragments that can be manufactured at high- er yields.
Patent SG-11201903873X-A (SG)
Title: Insulator for armature, motor
Inventor: SATOU JUNICHI
IPC: H02K3/34
Filed: 2017-10-25
Abstract: INSULATOR FOR ARMATURE, MOTOR A jumper line is disposed without using a printed circuit board and without increasing an axial dimension of an armature. An insulator (3) for an armature has holes 5 (H1 to H12) and guide portions (32A, 32B, 32C, 32F). The holes (H1 to H12) are penetrated by pins (Puas, Puae, Pwas, Pwae, Pvbs, Pvbe, Pubs, Pube, Pwbs, Pwbe, Pvas, Pvae). The pins (Puas, Puae, Pwas, Pwae, Pvbs, Pvbe, Pubs, Pube, Pwbs, Pwbe, Pvas, Pvae) are connected to one ends of corresponding coils (Lu1, Lu2, Lw1, Lw2, Lv3, Lv4, Lu3, Lu4, Lw3, Lw4, Lv1, Lv2), respectively. The guide portions (32A, 32B, 32C, 32F) 10 respectively guide the jumper lines (Pn, Pxu, Pxv, Pxw) in a circumferential direction with respect to an axis (J0). [FIG. 1]
Patent SG-11201907440Q-A (SG)
Title: Method and apparatus for determining index grids of geo-fence
Inventor: ZHANG HUI
Filed: 2018-05-31
Abstract: The present application provides a method for determining index grids of a geo-fence, including: determining a circumscribed grid of a geo-fence, the circumscribed grid being a smallest single grid containing the geo-fence; with the circumscribed grid as a starting point, subdividing grid(s) containing the boundary of the geo-fence into finer-grained grids level 5 by level until an index accuracy of a subdivided grid set is not lower than a predetermined precision threshold, wherein the grid set is composed of grids within the geo-fence and grids containing the boundary of the geo-fence, and the index accuracy is a ratio of an area of the geo-fence to a sum of areas of all the grids in the grid set; and taking the grids in the grid set as index grids of the geo-fence. According to the technical solution of the present application, 10 under the premise of fully containing the geo-fence and meeting the precision requirement, the number of index grids is greatly decreased, index storage is less complex, index query speed is increased, and the stability and response speed of a geo-fence-based service are improved.
Patent HU-199388-B (HU)
Inventor: NYEKI GYOERGYNE
IPC: C07C229/04
Filed: 1988-01-11
Abstract: A találmány tárgya javított eljárás az α-aminosavak terc.-butil-észterének és/vagy terc.-butil-éterének szerves sav jelenlétében, oldószeres közegben, hűtés mellett izobutilénnel történő reagáltatás útján való előállítására. A találmány szerint úgy járnak el, hogy a szabad észterezni és/vagy éterezni kívánt karboxil-, és/vagy hidroxil- vagy szulfhidril-csoportot és védett amino-, valamint adott esetben alkil- vagy aralkil-csoporttal védett észterezni vagy eterezni nem kívánt karboxil- vagy hidroxilcsoportot tartalmazó a-aminosav-származékot diklór-metánban oldva, 10—20 mól% trifluor-metán-szulfon- sav katalizátor jelenlétében —5 — —35°C közötti hőmérsékleten, légköri nyomáson 1 — 4 órán át izobuténnel reagáltatják, majd a reakció lezajlása után a reakcióelegyet ugyanezen a hőmérsékleten egy tercier aminnal vagy piridinnel semlegesítik, és kívánt esetben az elkülönített terc.-butilezett α-aminosav-származékról önmagában ismert módon savas vagy lúgos közegben végzett hidrolízissel vagy hidrogenolízissel lehasítják a védőcsoportot és a kapott terc.-butilezett α-aminosav származékot kívánt esetben savval vagy bázissal végzett kezeléssel történő sóvá alakítás után elkülönítik. H U 199388 A A leírás terjedelme: 5 oldal -1-
Patent AT-396052-B (AT)
Title: Ski boot
IPC: A43B5/04
Filed: 1987-02-25
Granted: 1993-05-25
Abstract: The invention describes a ski boot with a shell 1 forming a sole 2, a shaft which is articulated on the shell 1 by means of at least one pivoting axis in the region of the inner ankle-bone and of the outer ankle-bone and is composed of a heel flap 5 and a shaft front-part, with a foot holder 8 arranged in the instep region inside the shell 1, and with a tension member 10 which engages on the heel flap 5 on both sides of the boot, stretches around the foot holder 8 and is guided from a deflecting guide fixed to the heel flap on one side of the boot to a tensioning device 9 which can be adjusted by means of a rotary grip. The tensioning device 9 is formed in a manner known per se from a threaded bolt 13, which is arranged above the foot holder 8 transversely to the instep, held axially undisplaceably in the shell 3 and provided with the rotary grip 14, and a nut 15 which is mounted on the threaded bolt 13, supported non- rotationally in relation to the shell 3 and on which the tension member 10 engages. One end of the threaded bolt 13 is assigned a deflecting guide 17, fixed to the shell, for the tension member 10 which, between the nut 15 and the adjacent deflecting guide 17, runs at least approximately parallel to the threaded bolt 13. <IMAGE>
Patent AT-396495-B (AT)
Title: Building
IPC: E04B1/348
Filed: 1992-04-10
Granted: 1993-09-27
Abstract: The invention relates to a building which can be used in a number of different ways and can be erected from prefabricated compound units. It is constructed from prismatic room elements 1 of octagonal outline, it being possible for any desired size of structural surfaces to be assembled, by arranging the octagonal room elements 1 in rows one beside the other, such that a smaller, square element 2 remains in each case between four adjacent octagonal room elements. The load-bearing structure comprises a steel skeleton for the octagonal room elements, the side surfaces of which may optionally comprise facade elements or intermediate wall elements or may be omitted, this making it possible to form rooms of any desired size. The invention consists in the fact that the beams 4, which cross over the bottom and top surfaces of the octagonal room elements 1, run towards opposite columns and form load-bearing elements of the floor and ceiling, are designed in the form of a beam grid which comprises four beams, of which in each case two run parallel to one another, are of the same length and intersect the respectively other two beams at rightangles. <IMAGE>
Patent HU-216860-B (HU)
Title: Process and apparatus for preparing especially purifying water containing halogenated ethylene
Inventor: ESCHWEILER HELMUT
IPC: C02F1/78
Filed: 1990-07-13
Abstract: The invention relates to a process and device for treating,in particular cleaning, water containing halogenated ethylenes, preferably ground water, for use and/or consumption by humans and animals, in which the water is exposed to the action of ozone and to high-energy, in particular ionizing, radiation. In a preliminary treatment, ozone is added to and/or mixed with water of essentially drinking water quality except for the above-mentioned halogenated ethylene constituents and/or harmful substances, and/or drinking water brought to this quality, in particular ground water. The circulating water is then irradiated with electrons. The ozone concentration in the water is such that, or is so adjusted that, immediately after leaving the irradiated region the water has an ozone concentration of at least 0.1 ppm.
Patent HU-186634-B (HU)
Title: Process for preparing 6-methyl-delta4,6-3-keto-steroids
Inventor: ANNEN KLAUS
IPC: C07J5/00
Filed: 1983-02-04
Abstract: A process for preparing 6-methyl-Δ<sup>4,6</sup>-3-keto steroids ofwherein X is, comprises reacting a corresponding Δ<sup>4</sup>-3-keto steroid with methoxymethyl acetate (CH<sub>3</sub>-O-CH<sub>2</sub>-OAc) in an inert solvent at temperatures above room temperature in the presence of an alkali metal acetate.
Patent HU-196270-B (HU)
Title: High-pressure mercury-vapour discharge lamp with improved current lead-trough
Inventor: KUUS GIJSBERT
IPC: C08L63/00
Filed: 1980-02-22
Abstract: The lead-through foil 14 (e.g. Mo or W) in the pinch seal 12 of a metal halide-containing high-pressure mercury-discharge lamp has a coating of Ta, Nb, V, Cr, Zr, Ti, Y, La, Sc or Hf which may be deposited  mu m thick which may be deposited by vapour decomposition, sputtering, electrolysis, ion plating or CVD. The gastightness of seal 12 is thereby improved. Moreover, if a part 33 of an external current conductor 20 situated in the pinch seal 12 is also formed, at least at its surface, from one of the said coating metals, it prevents alkali metals escaping from the filling inside the discharge vessel 10. <IMAGE>
Patent HU-187646-B (HU)
Inventor: PENTEK ISTVAN
IPC: C02F1/66
Filed: 1982-02-18
Abstract: A találmány olyan eljárásra vonatkozik, mely során a hígtrágyák és élelmiszeripari szennyvizek folyékony fázisát, amelynek szilárdanyag tartalma 0,5-5.01% közötti, szuszpenziós műtrágyává alakítják. A találmány szerinti eljárást az jellemzi, hogy a hígtrágya vagy élelmiszeripari szennyvíz folyékony fázisának pH-ját 0,5-1,5 közé állítjuk be sav, előnyösen kénsav adagolásával, az elegyhez kiegészítő adalékként szervetlen kálium-sót és/vagy foszfátvegyületet, előnyösen monoammónium-foszfátot és/vagy nitrogén-forrást, előnyösen karbamidot, kevernek és az elegy pH-ját az adalékok bekeverése közben szervetlen lúggal, előnyösen ammóniumhidroxiddal, PH 8-12-re állítják be, hozzáadnak az elegy összmennyiségére számítva 5-15 s% mennyiségű 40-60 s% nedvességtar-almú meddő-iszap szuszpendáló szert, majd elegyet adott esetben 50-85 °C-ra melegítik és addig keverik, míg homogén szuszpenziót nyernek. -1-
Patent HU-191590-B (HU)
Title: Fungicide compositions containing derivatives of pyridine, pyrazine or pyrimidine as active ingredients and process for preparing the active ingredients
Inventor: DORN FRANZ
IPC: A01N43/60
Filed: 1984-02-24
Abstract: Die Erfindung betrifft neue Pyridin-, Pyrazin- und Pyrimidinderivate der Formel
     worin R, R 1 , R 2 , R 3  und R 4  die in der Beschreibung angegebenen Bedeutungen besitzen, und ihre Säureadditionssalze, Verfahren zu deren Herstellung, fungizide Mittel, die diese Verbindungen als Wirkstoffe enthalten sowie die Verwendung solcher Verbindungen bzw. Mittel zur Bekämpfung von Fungi in der Landwirtschaft und im Gartenbau. Die Erfindung betrifft ferner bei der Herstellung von Verbindungen der Formel I verwendbare Mittel.
Patent HU-186847-B (HU)
Inventor: CSAKI JANOS
IPC: F16L15/04
Filed: 1982-03-17
Abstract: A találmány folyadékokat, illetve légnemű anyagokat szállító csővezetékek menet-nélküli összekötésére alkalmas. A találmány szerinti gyors-összekötő cső 1 db kétoldalán menetes fix csőből, 2-2 db puha, illetve fémtömítésből és 2 db hollander anyából áll. A cső, hollander, illetve tömítések anyagai alkalmazástól függó'en választandó meg.  d L -Q -a -1-
Patent HU-183396-B (HU)
Inventor: SUNYOVSZKY KALMAN
IPC: A23N5/00
Filed: 1981-04-15
Abstract: Folyamatos működésű gesztenyepergető gép főleg
gesztenyemassza előállításához. A gép alkalmas főtt
gesztenye héjának folyamatos eltávolítására és a bélzet
folyamatos kinyerésére, úgy, hogy a héjban maradó bélzet
minimális továbbá a bélzet héjtartalma szintén alacsony.
A gép működése során a nyitott garaton át pergető
dobba jut, ahol gyors forgású verőlécek a gesztenye
héját feltörik, a bélzetet felaprítják. Továbbító lapátok
folytonos anyagáramlást biztosítanak a pergető dobban.
A bélzet a dob alsó palástfelületén levő rostán távozik,
míg a héj a dob végén kialakított héjkiadó nyíláson.
A kipergetett bélzetet hűtőköpennyel ellátott szállítócsiga
viszi ki a gépből.
Patent LT-4396-B (LT)
Title: Composition for aromatised wine
Inventor: SARGUNAS GEDIMINAS
IPC: C12G3/06
Filed: 1998-02-19
Abstract: Invention renders new ingredient composition of alcoholic drink, the aromatic vine. This composition consists of red grape vine, water-alcohol mixture and other such components as sugar, milk acid, nut fragrance, caramel, vanilla, peppermint stringybark (Mentha piperita) surface part, citric (Citrus limon Burm) peel, surface part of common wormwood (Artemicia absintium), dill (Anethum graveolens) fruits, cinnamon (Cinnamonum) cortex, nutmeg (Myristica fragrans), surface part of basil (Ocimum mentifolium), elder (Sambucus nigra) frowers, surface part of tarragon (Artemicia dracunculus), surface part of thyme (Thumus vulgaris), fruits of coriander (Coriandrum sativum), surface part of milfoil (Adrrillea millefolium), surface part of Saint-John's wort (Hypericium perforatum), lime-tree flowers (Tilia cordata), chamomile flowers (Matricaria chamomilla), sweet-flag root-stocks (Acorus calamus), roots of sneezeweed (Inula helenium), valerian root-stocks (Valeriana officinalis), lemon balm (Melissa officinalis) surface part, masterwort (Archangelica officinalis) root-stocks, flowers of everlasting (Helichrysum arenarium) and fruits of hawthorn (Crataegus).
Patent ZA-80802-B (ZA)
Title: Coating process
Inventor: DOROSZKOWSKI A
IPC: C09D5/44
Filed: 1980-02-12
Abstract: A coating process in which an article to be coated is immersed as an anode in a dispersion of a film-forming material stabilized by non-ionic stabilization and an electric current is passed between the anode and another electrode immersed in the dispersion. The dispersion is destabilized in the region of and is deposited on the anode by interaction between a moiety providing the non-ionic stabilization (e.g. of polyethylene glycol) and a further interactive moiety (e.g. carboxyl groups present in polymethacrylic acid) present in the dispersion. Suitable coating compositions and coated articles are defined.
Patent AT-378301-B (AT)
Inventor: WEISSENSTEINER WALTER DIPL ING
IPC: G11B5/588
Filed: 1983-06-17
Granted: 1985-07-25
Abstract: A system for the reproduction of signals stored in diagonal tracks (S1,S2,S3,S4,S5,S6,S7, . . . ) on a magnetic tape (1) incorporates a drum-shaped scanning device (2) with at least two magnetic heads (K1,K2), each mounted on an electro-mechanical adjusting device (A1,A2), of which magnetic heads only one is in scanning contact with the magnetic tape during first scanning intervals (T1) while during second scanning intervals (T2) both are in scanning contact with the magnetic tape (1), which is partly wound round the scanning device (2). For generation of the adjustment signals to be applied to the adjusting devices (A1,A2) for the purpose of guiding the magnetic heads (K1,K2) along the tracks-signals containing a measurement of the deviations of the magnetic heads from the track-an adjustment-signal generating circuit (14) is provided, to which the signals reproduced by the two magnetic heads simultaneously in scanning contact are taken in time-division multiplex form during the second scanning interval (T2), signals generated in the adjustment-signal generating circuit (14) and corresponding to the adjustment signals for the two adjustment devices (A1,A2) of these magnetic heads being taken on a TDM basis via a second switching device (40) controlled in a similar manner to the first switching device (29) to storage circuits (36,37) connected at the inputs to these adjustment devices (FIG. 4).
Patent DK-163927-B (DK)
Title: Process for preparing alkyl-, cycloalkyl-, alkenyl- or cycloalkenylaldosides or -oligoaldosides
Inventor: DEFAYE JACQUES
IPC: C08B1/00
Filed: 1986-03-14
Abstract: PCT No. PCT/FR85/00197 Sec. 371 Date Apr. 18, 1986 Sec. 102(e) Date Apr. 18, 1986 PCT Filed Jul. 18, 1985 PCT Pub. No. WO86/00906 PCT Pub. Date Feb. 13, 1986.The process comprises the action of a saturated aliphatic or cycloaliphatic alcohol or an aliphatic or cycloaliphatic alcohol comprising a double ethylenic bound not situated in alpha of the hydroxyl group with an aldose, aldoside or polyaldoside in the solvent and reactant formed by the hydrogen fluoride. Application to the synthesis of surfactants or as additives for rigidifying polyurethane foams.
Patent DK-157552-B (DK)
Inventor: AUBERT DANIEL
IPC: C07D495/04
Filed: 1983-07-01
Abstract: This invention relates to new thieno [3,2-c] pyridine derivatives having the formula:    <IMAGE>  (I)  in which: Y represents the OH group or an OR group in which R is a straight or branched lower alkyl radical, or Y represents a group   <IMAGE>  in which R1 and R2 are each independently of each other, hydrogen or a straight or branched lower alkyl group; or R1 and R2 form together and with the nitrogen atom to which they are attached a heterocycle which may include a second heteroatom such as oxygen or nitrogen, wherein the latter may be substituted by a lower alkyl or benzyl radical which may be substituted; and X represents hydrogen, a halogen or a lower alkyl radical; and their addition salts with pharmaceutically acceptable mineral or organic acids if Y represents the group OR or    <IMAGE> or with mineral bases if Y represents OH, as well as the two enantiomers or their mixture. The invention also relates to the preparation process of new thieno [3,2-c] pyridine derivatives and to their therapeutic application as blood-platelet aggregation inhibiting agents and antithrombotics.
Patent FI-89072-B (FI)
Inventor: REISCHL ARTUR
IPC: C02F3/10
Filed: 1986-07-21
Granted: 1993-04-30
Abstract: 1. Process for the preparation of polymer-bound carrier masses containing fillers, characterised in that A) fillers based on prefinished, lumpy or pulverulent voams and/or fossil ligno cellulose powders and/or carbon powders and optionally other inorganic or organic fillers and/or optionally living and/or dead biological cell material in a quantity of from 5 to 97% by weight, based on A) and B), are mixed with B) nonionic-hydrophilic, anionic or cationic, aqueous, coagulable and film forming polymer dispersions having a solids content of from 3 to 60% by weight, optionally with the addition of C) water so that the total water content, based on all components, amounts to 20 to 90% by weight, and optionally with the addition of D) other auxiliary agents and additives and the polymer dispersion is then brought to coagulation.
Patent FI-84421-B (FI)
Inventor: BERKE PHILIP A
IPC: A01N43/80
Filed: 1987-02-25
Granted: 1991-08-30
Abstract: Compositions of matter containing a compound which is a member selected from the group consisting of hydroxymethylaminoacetic acid, its salts and lower alkyl esters, and one or more 3-isothiazolones are disclosed. The compositions provide synergistic microbial growth inhibition and biocidal activity in a wide range of substances requiring antimicrobial protection.
Patent FI-87511-B (FI)
Inventor: HEWETT RICHARD HENRY
IPC: A01N43/40
Filed: 1987-07-20
Granted: 1992-10-15
Abstract: The present invention relates to a method of controlling the growth of weeds at a cereal crop locus which comprises applying to the locus (a) diclofop, which is (R,S)-2-[4-(2,4-dichlorophenoxy)phenoxy]-propionic acid or an agriculturally acceptable salt or ester thereof and (b) diflufenican which is N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)nicotinamide.
Patent FI-92879-B (FI)
Inventor: LENZ HELMUT
IPC: G01N33/574
Filed: 1989-03-02
Granted: 1994-09-30
Abstract: A method for the determination of a polyvalent substance which is capable of immunological binding in the presence of at least two reactants which are specific for the substance which is capable of immunological binding, in the presence of an aggregated substance with a concentration of 0.1 to 50  mu g/ml to compensate for interfering factors in human serum samples, and a reagent suitable for this purpose.
Patent FI-90971-B (FI)
Title: Binder for cast ceiling tile, cast ceiling tile, and method for manufacture thereof
Inventor: KESKEY WILLIAM H
IPC: C04B26/04
Filed: 1989-08-15
Granted: 1994-01-14
Abstract: Cast ceiling tile requires a particular rheology of its wet formulation for the dried tile to have a desired aesthetic appearance. The tile is prepared by blending mineral wool with a premixture of water, latex, and filler, said premixture having a sharp yield point when measured with a recording Brookfield Viscometer. The latex is an alkali-swellable latex comprising (i) a C3-C8  alpha , beta -ethylenically unsaturated carboxylic acid monomer in an amount of from 15 to 60 weight percent based on the weight of the monomers in the copolymer; (ii) at least one of a copolymerizable nonionic vinyl monomer in an amount of from 45 to 30 weight percent based on the weight of the monomers in the copolymer; and (iii) a late feed of additional nonionic vinyl monomer in an amount of from 10 to 40 weight percent based on the weight of the monomers in the copolymer. Cast ceiling tiles using the present latex binder have better resistance to sagging and warping than cast ceiling tiles using starch as the binder.
Patent FI-85579-B (FI)
Title: Method and device for moulding of pressed glass articles
Inventor: ZIEGLER MICHAEL J
IPC: C03B/
Filed: 1990-01-05
Granted: 1992-01-31
Abstract: A system for forming hollow pressed glass articles (20) utilizes a flow of cryogen that is mixed with air supplied by tube (50) to provide a cooling gas that enables newly pressed articles to be removed from their molds after a thin skin of solidified glass has been formed on internal surfaces of the articles. Two flows of cryogen are used, one being a gentle, substantially continuous flow of cryogen gas, the other being a controlled intermittent flow of cryogen vapor in liquid and/or gaseous form. To assure a proper introduction of cryogen vapor, and to prevent debilitating accumulations of ice within and about the tube that is used to inject high pressure cryogen, the high pressure injector tube (62) is surrounded by a low pressure cryogen tube (64), through which a flow of low pressure cryogen gas is maintained on a substantially continuous basis.