baber/WOPTO huggingface dataset:
Patent CA-3099152-A1 (CA)
Title: Mcl-1 inhibitors
Inventor: CHU HANG
IPC: A61K31/553
Filed: 2019-05-13
Abstract: The present disclosure generally relates to compounds of general Formula (I): and pharmaceutically acceptable salts thereof, which are inhibitors of myeloid cell leukemia 1 protein (MCL-1 ), and pharmaceutical compositions thereof that may be used treating cancer.
Patent CA-3099642-A1 (CA)
Title: Vecteurs de co-expression d'inhibiteurs de points de controle immunitaires
Inventor: BLAIR WADE
IPC: C07K16/28
Filed: 2019-05-23
Abstract: L'invention concerne des vecteurs qui comprennent des séquences d'acides nucléiques codant pour un antigène et qui co-expriment des modulateurs immunitaires. L'invention concerne également des nucléotides, des cellules et des méthodes associées à ces vecteurs, notamment leur utilisation en tant que vaccins.
Patent CA-3101948-A1 (CA)
Inventor: HAZIZA DEDI DAVID
IPC: H01Q1/38
Filed: 2018-05-01
Abstract: A transmission conduit for RF signal, comprising: a dielectric plate; a conductive circuit positioned on one surface of the dielectric plate; a conductive ground positioned on opposite surface of the dielectric plate; wherein the dielectric plate comprises a sandwich of at least one high-dielectric constant layer and one foam plate. The dielectric plate can be made of a sandwich of glass and foam plate, such as Rohacell®. The glass and foam plates have thickness calculated to give the sandwich the required overall dialectic constant.
Patent CA-3105695-A1 (CA)
Title: Computer-automated software release and deployment architecture
Inventor: SHTEYMAN YULY
IPC: G06F8/60
Filed: 2021-01-12
Abstract: A software deployment system includes a release module, a deployment control module, and a deployment module. The release module is configured to generate a first release object identifying a specific version of a first set of files in a version control system. The files encode deployment parameters, including a pointer to an executable form of a first application. The deployment control module is configured to promote the first release object to an environment by copying the first set of files to a location in the version control system corresponding to the environment. The deployment module is configured to, after the first release object is promoted to an environment, deploy the first release object by:  configuring the environment according to the deployment parameters; copying the executable form of the first application from the pointer location to the environment; and initiating execution of the copied executable fomi in the environment.
Patent CA-3106275-A1 (CA)
Title: Dynamically rigidizing composite medical structures
Inventor: TILSON ALEXANDER Q
IPC: A61B1/00
Filed: 2019-07-19
Abstract: A rigidizing device includes an elongate flexible tube, a braid layer positioned over the elongate flexible tube, an outer layer over the flexible tube and the braid layer, and an inlet between the elongate flexible tube and the outer layer and configured to attach to a source of vacuum or pressure. The braid layer has a plurality of strands braided together at a braid angle of 5-40 degrees relative to a longitudinal axis of the elongate flexible tube when the elongate flexible tube is straight. The rigidizing device is configured to have a rigid configuration when vacuum or pressure is applied through the inlet and a flexible configuration when vacuum or pressure is not applied through the inlet. The braid angle is configured to change as the rigidizing device bends when the rigidizing device is in the flexible configuration.
Patent CA-3106854-A1 (CA)
Inventor: SCHAEPER UTE
IPC: A61P39/04
Filed: 2019-07-26
Abstract: The present invention relates to products and compositions and their uses. In particular the invention relates to nucleic acid products that interfere with the TMPRSS6 gene expression or inhibits its expression in combination with one or more iron chelators and possibly other active agents, as well as therapeutic uses such as for the treatment of hemochromatosis, porphyria and blood disorders such as beta-thalassemia, sickle cell disease and transfusional iron overload or myelodysplastic syndrome, and infections and non-relapse related mortality associated with bone marrow transplantation.
Patent CA-3108218-A1 (CA)
Inventor: MANTYLA JAMES
IPC: E03F7/04
Filed: 2021-02-05
Abstract: A normally open backwater prevention valve for connecting to a sanitary drainpipe. The valve has an inflow end to connect to an upstream part of the drainpipe, and an out-flow end to connect to a downstream part of the drainpipe. There is a main body defining a flow through chamber extending between the inflow and the out-flow ends and a valve seat formed on an upstream side of the main body which faces downstream. A float assembly having opposed floats on opposite sides of the flow through chamber has a check valve assembly including at least a valve member located between the opposed floats. The valve member is sized and shaped to seal on the valve seat, and is operatively connected to the float assembly through a gear box. When the floats are down the valve member is in an open position and when the floats are up the valve member is moved to a closed position on the valve seat. Also provided is an access opening on a top of the flow through chamber, and a removable cover for sealing the access opening.
Patent CA-3109320-A1 (CA)
Title: Recepteur antigenique chimerique bcma base sur un anticorps a domaine unique et son utilisation
Inventor: ZHANG JISHUAI
IPC: A61K39/395
Filed: 2019-07-10
Abstract: L'invention concerne un récepteur antigénique chimérique (CAR) et son utilisation, le CAR comprenant : un domaine de liaison BCMA, un domaine transmembranaire, un ou plusieurs domaines de co-stimulation, et un domaine de signalisation intracellulaire, le domaine de liaison BCMA comprenant des régions de détermination de la complémentarité de chaîne lourde HCDR1-3, et les séquences d'acides aminés de HCDR1-3 étant successivement représentées dans SEQ ID NO : 1-3.
Patent CA-3109732-A1 (CA)
Title: Cellules nk cryoconservees prechargees avec une construction d'anticorps
Inventor: REUSCH UWE
IPC: A61K39/395
Filed: 2019-08-26
Abstract: L'invention concerne des cellules NK humaines isolées dans un état cryoconservé, préchargées avant la congélation avec une construction d'anticorps, la construction d'anticorps comprenant au moins un premier domaine de liaison se liant à un antigène de récepteur de cellule NK sur la surface cellulaire d'une cellule effectrice immunologique et un second domaine de liaison se liant à un antigène de surface cellulaire sur la surface cellulaire d'une cellule cible, un procédé de préparation de cellules NK humaines préchargées cryoconservées et des compositions pharmaceutiques comprenant des cellules NK humaines qui ont été reconstituées à partir des cellules NK humaines dans un état cryoconservé.
Patent CA-3113794-A1 (CA)
Title: Systems for identifying the answering party of an automated voice call
Inventor: BENKREIRA ABDELKADER
IPC: G10L15/22
Filed: 2021-03-31
Abstract: Disclosed herein are systems and methods for determining whether an automated telephone call has been answered by a particular user, a different person, or a voicemail service. In response to determining that the call has been answered by the user, a different person, or a voicemail service, the systems and methods can output different respective messages, initiate messaging to the user via alternate communication paths, or perform other actions.
Patent CA-3114595-A1 (CA)
Title: Systeme de surveillance pour le suivi de vehicules
Inventor: GHARB SAMY
IPC: G07B15/06
Filed: 2019-10-23
Abstract: L'invention concerne un système de surveillance pour le suivi de véhicules, par exemple d'automobiles, de bus ou de yachts, comprenant des lecteurs optiques qui sont conçus pour acquérir des codes lisibles par machine, ces codes lisibles par machine étant placés sur les véhicules, en particulier sur les plaques d'immatriculation des véhicules. L'invention concerne en outre un procédé de surveillance de véhicules, ainsi qu'une plaque d'immatriculation destinée à être utilisée dans un procédé selon l'invention.
Patent CA-3115637-A1 (CA)
Inventor: CHOI JIN WOO
IPC: A61P25/28
Filed: 2020-03-16
Abstract: The invention relates to recombinant vectors comprising an AIMP2 splice variant and miR-142 target nucleic acid and its diverse range of applications. The AIMP2 variant can be used beneficially in relevant industries since it can specifically be expressed in neuronal cells and brain tissues.
Patent CA-3116638-A1 (CA)
Inventor: PIETRZAK CHRISTOPHER
IPC: A42B3/06
Filed: 2019-10-14
Abstract: A pad (50) for mounting to a helmet (1), the pad comprising a support member (51), a first layer of material (52) arranged to cover a first side of the support member and a second layer of material (53) arranged to cover the first layer of material, wherein a low friction interface (57) is arranged between the first layer of material and the second layer of material to enable sliding of the first layer of material relative to the second layer of material, wherein each layer of material is formed from at least one of a textile, a cloth, a fabric and a felt.
Patent CA-3116779-A1 (CA)
Inventor: VAN DER MERWE JACOBUS JOHANNES
IPC: C05B11/08
Filed: 2019-10-07
Abstract: The invention relates to a method of manufacturing phosphate fertiliser that comprises dicalcium phosphate comprising providing milled phosphorus-containing rock having a total phosphorus content of at least about 15% P by weight, mixing the milled phosphate-containing rock with a mineral acid in a reaction vessel to produce a superphosphate product, and mixing the superphosphate product with a calcium-source reverting agent and a magnesium-source reverting agent to produce a reverted product, the calcium-source reverting agent comprising at least about 20% by weight of the total reverting agent of calcium oxide with a calcium carbonate equivalence of at least about 134%, and the magnesium-source reverting agent providing a magnesium source and comprising at least about 20% by weight of the total reverting agent of magnesium source with a calcium carbonate equivalence of at least about 80%, to produce a granulated cured reverted product having a product yield of at least about 1.90 or a product yield of at least about 1.77 and a moisture content of less than 3%.
Patent CA-3120411-A1 (CA)
Inventor: ADESOKAN ADEYEMI
IPC: A61P1/00
Filed: 2019-11-19
Abstract: L'invention concerne des compositions comprenant des glycopeptides obtenus à partir de mucines gastro-intestinales qui présentent des effets supérieurs sur le microbiote, et des procédés de fabrication et des méthodes d'utilisation de celles-ci. De telles compositions sont avantageuses pour des applications pharmaceutiques, alimentaires et pour l'alimentation des animaux de compagnie.
Patent CA-3120600-A1 (CA)
Title: Kitchen appliance for processing food
Inventor: BODUM JORGEN
IPC: A47J42/40
Filed: 2019-11-07
Abstract: The invention relates to a kitchen appliance for processing food, comprising a housing (15), in or on which a drive unit (18) is arranged for driving a processing tool (20) for processing food, and an actuation mechanism (32) for actuating the drive unit (18). The actuation mechanism (32) comprises a movable switch element (34) which is arranged outside of the housing (15), a switch (36) which is arranged within the housing (15), and an opening (40) which passes through the housing (15). The switch (36) can be switched by the switch element (34) in order to actuate the drive unit (18) in that the switch element (34) is moved relative to the switch (36), and the kitchen appliance (10) has a seal element (42) which sealingly closes the opening (40) and transmits the movement of the switch element (34) to the switch (36).
Patent CA-3120706-A1 (CA)
Inventor: NAIK SNEHAL
IPC: A61K31/404
Filed: 2019-11-26
Abstract: L'invention concerne une méthode pour déterminer si un individu est un sujet répondant à un traitement avec de l'acide (R)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclopenta[b]indol-3-yl) acétique (Composé 1) ou un sel, un solvate ou un hydrate pharmaceutiquement acceptable de celui-ci.
Patent CA-3123086-A1 (CA)
Title: Bifunctional molecules for lysosomal targeting and related compositions and methods
Inventor: BERTOZZI CAROLYN
IPC: C07K16/18
Filed: 2019-12-18
Abstract: Provided are bifunctional molecules that include a first moiety that specifically binds a cell surface molecule or extracellular molecule, and a second moiety that specifically binds a lysosomal targeting molecule. The bifunctional molecules find use, e.g., for targeted degradation of cell surface and extracellular molecules (e.g., proteins) via the endosomal/lysosomal pathway. Also provided are compositions and kits that include the bifunctional molecules, as well as methods of using the bifunctional molecules. Methods of making bifunctional molecules are also provided.
Patent CA-3126673-A1 (CA)
Inventor: MOULON PIERRE
IPC: G01C21/00
Filed: 2021-08-04
Abstract: Il est décrit des techniques dutilisation dappareils informatiques aux fins de réalisation dopérations automatisées en vue de détermination de lemplacement dacquisition dune image à laide dune analyse du contenu visuel de limage. Dans au moins certaines situations, des images devant être analysées comprennent des images de panorama à des emplacements dacquisition à lintérieur dun bâtiment à plusieurs pièces, et les informations demplacement dacquisition déterminé comprennent un emplacement sur un plan détage du bâtiment et, dans certains cas, des informations de direction dorientation dans au moins certaines des telles situations. La détermination de lemplacement dacquisition est réalisée sans posséder ou utiliser des informations à partir de dispositifs de mesure de distance concernant des distances dun emplacement dacquisition dune image à des objets dans le bâtiment avoisinant. Les informations demplacement dacquisition peuvent servir de différentes façons automatisées, notamment le guidage dappareils (comme les véhicules autonomes) et laffichage dau moins un appareil utilisateur dans une interface utilisateur graphique.
Patent CA-3127790-A1 (CA)
Title: Systeme d'eclairage pour situer des balises de sol sans fil dans un espace
Inventor: GEORGE SAJIN
IPC: H04W4/02
Filed: 2021-08-11
Abstract: Par suite de la réception du message de demande délément de système déclairage à partir dune passerelle pour détecter un sous-ensemble ou toutes les balises de sol radiofréquence sans fil dans lespace, un élément de système déclairage reçoit, par un réseau de communication sans fil local, un message didentification de balise de sol comprenant un identificateur de balise radiofréquence sans fil respectif transmis à partir dune balise de sol radiofréquence sans fil respectif détecté. Lélément de système déclairage détermine une intensité du signal radiofréquence respective entre la balise de sol radiofréquence sans fil respective détectée à partir de lélément de système déclairage respectif d'après le message didentification de balise de sol respectif. Les éléments de système déclairage transmettent à la passerelle, par le biais du réseau de communication sans fil local, un message de rapport délément de système déclairage respectif comprenant lidentificateur de balise radiofréquence sans fil respectif détecté de la balise de sol radiofréquence sans fil respective, lintensité du signal radiofréquence respectif, et lidentificateur délément de système déclairage respectif.
Patent CA-3129094-A1 (CA)
Inventor: ALBRECHT MELVIN J
IPC: F22B37/14
Filed: 2020-02-06
Abstract: A boiler includes a steam drum, an intermediate drum, and a lower drum. Each drum is divided into a clean section and a concentrated section. A channel that is fluidly connected to the clean section also runs down one side of the concentrated section in the intermediate drum and the lower drum. The presence of the channels permits low-quality feedwater tubes and high-quality feedwater tubes to be arranged in parallel rows next to each other.
Patent CA-3129334-A1 (CA)
Title: Device for the discrimination of biological tissues
Inventor: ORTEGA-QUIJANO NOE
IPC: A61B5/00
Filed: 2019-02-28
Abstract: The present invention relates to a device for the discrimination of biological tissues, such that it is capable of carrying out the discrimination of tissue under complicated operating conditions, for example due to the presence of contaminating elements given off by a cutting operation, due to the presence of moisture in the biological tissue, or due to the presence of a non-controlled atmosphere that interferes with the results of the readings. The invention allows building more complex devices, including cutting instruments, such that it is possible to carry out a surgical intervention in a safe manner by preventing cutting into tissues that are to be avoided during said cutting operation.
Patent CA-3129869-A1 (CA)
Title: Pooled genome editing in microbes
Inventor: BLASKOWSKI STEPHEN
IPC: C12N15/77
Filed: 2020-03-06
Abstract: The present invention relates to methods for editing the genome of a microbial host cell in one or more rounds of transformation. The method allows the introduction of genetic edits into the genome of a microbial host cell in a pooled and/or iterative fashion that does not require the use of functional counterselection following at least one round of transformation. It can be used to rapidly stack genetic edits in the genome of a microbial host cell. Compositions and kits for performing the methods are also disclosed.
Patent CA-3133361-A1 (CA)
Title: Procedes et compositions pour l'insertion de sequences de codage d'anticorps dans un locus d'hebergement sur
Inventor: WANG CHENG
IPC: C07K16/10
Filed: 2020-04-02
Abstract: L'invention concerne des procédés et des compositions pour intégrer des séquences de codage pour des protéines de liaison à un antigène telles que des anticorps largement neutralisants dans un locus d'hébergement sûr tel qu'un locus d'albumine chez un animal in vivo.
Patent CA-3135368-A1 (CA)
Inventor: ZARUR ANDREY J
IPC: C12N1/06
Filed: 2020-03-30
Abstract: This invention relates to in vitro production of nucleic acids, particularly RNAs and specifically messenger RNAs (mRNA).
Patent CA-3137336-A1 (CA)
Inventor: KNIGHT TYLER H
IPC: B25F3/00
Filed: 2021-11-02
Abstract: A power tool includes a power head receiving power from a power source. A drive coupled to the power head extends along a longitudinal axis, and the drive is engaged with a connector. Various aspects relate to the connector. The connector includes an internal bore configured to couple to the drive to a shank of a working tool. The connector further includes an external lobe protruding radially outward from the longitudinal axis, the lobe having a locking mechanism configured to secure the second working tool in response to relative movement between the lobe and the second working tool in both an axial direction and a rotational direction.
Patent CA-3138142-A1 (CA)
Title: Variete de soya 5pqvc29
Inventor: HEMINGWAY JOEL REESE
IPC: A01H1/00
Filed: 2021-11-08
Abstract: Une nouvelle variété de soja désignée 5PQVC29 est fournie. Les graines de la variété de soja 5PQVC29, les cellules de la variété de soja 5PQVC29, les plantes de soja 5PQVC29 et les parties des plantes de la variété de soja 5PQVC29 sont également fournies. Les procédés fournis abordent la production dune plante de soja par le croisement de la variété de soja 5PQVC29 avec une autre plante de soja, lintrogression dun trait transgénique, dun trait mutant ou dun trait natif de la variété de soja 5PQVC29, la production dautres variétés de soja ou dautres parties de plantes dérivées de la variété de soja 5PQVC29 et la caractérisation de la variété de soja 5PQVC29. Les graines, cellules, plantes, germoplasmes, souches généalogiques, variétés et parties de plantes produites par les procédés précédents et/ou dérivés de la variété de soja 5PQVC29 sont aussi fournis.
Patent CA-3138960-A1 (CA)
Title: System and process for online determination of the characteristics of worn balls and ball fragments of the same
Inventor: TITICHOCA AGUIRRE GILDA VERONICA
IPC: B02C15/00
Filed: 2020-05-02
Abstract: The present invention relates to a system and process carried out after a process of separating pieces of steel from pieces of ore that come out of a semi-autogenous grinder for grinding ores, and which consists of a system formed by one or more instruments for capturing images, each one being sensitive to light of different wavelengths, which point to the surface of an element for receiving the steel pieces or a channel that receives the steel balls and the pieces thereof from the separation process, through which the steel balls and pieces thereof move when they are discharged from this process, with the possibility of directing each image sensor such that it is not parallel to the others. By digitally processing the images obtained with the one or more sensors, the dimensions and morphology of the balls and ball pieces discharged from the separation process can be determined.
Patent CA-3139278-A1 (CA)
Title: Anti-carbonic anhydrase ix antibody
Inventor: TSAI BOR-YU
IPC: C12N9/88
Filed: 2019-05-06
Abstract: The present invention relates to epitopes located in CAIX and anti-CAIX antibodies having binding activity with cancer cells. The present invention also relates to the composition and application of the CAIX epitopes and anti-CAIX antibodies in the diagnosis, prevention and/or treatment of cancers.
Patent CA-3140604-A1 (CA)
Title: Method of selecting skin treatment regimens, ingredients and compositions
Inventor: CAPONE KIMBERLY
IPC: G01N33/50
Filed: 2020-05-12
Abstract: A method of selecting skin treatment regimens, ingredients and compositions that includes measuring the levels of particular small molecule metabolites on skin both before and after product application and testing for a change in small molecule metabolite levels is disclosed.
Patent CA-3144401-A1 (CA)
Title: E3 ligase binders and uses thereof
Inventor: QI JUN
IPC: A61K31/519
Filed: 2020-06-23
Abstract: Provided herein are compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein bind an E3 ubiquitin ligase (e.g., Cereblon) and induce degradation of a transcription factor (e.g., IKZF1, IKZF3). Also provided are pharmaceutical compositions comprising the compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers (e.g., carcinoma); leukemia, lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, ovarian cancer, colon cancer, colorectal cancer, multiple myeloma, and acute myeloid leukemia (AML))). Further provided are methods of inducing the degradation of a transcription factor (e.g., IKZF1, IKZF3) by administering a compound or composition described herein to a subject and/or to a biological sample (e.g., cell or tissue).
Patent CA-3145445-A1 (CA)
Title: Methods for sequencing polynucleotides
Inventor: PEACE JARED
IPC: C12Q1/6869
Filed: 2021-03-09
Abstract: The present invention relates to improvements in methods of high throughput nucleic acid sequencing, and in particular to improvements to methods of carrying out extension reactions during pairwise sequencing. The present invention relates to a method for carrying out a strand resynthesis extension reaction during pairwise sequencing, wherein said strand resynthesis extension reaction is carried out between a first sequencing read and a second sequencing read, and wherein said strand resynthesis extension reaction extends one or more immobilised primers to copy a first template strand to generate a second immobilised template strand; characterised in that the strand resynthesis extension reaction is carried out using a non- thermostable strand displacement polymerase at a temperature of less than 55 °C, preferably at 38 °C.