Patent SG-11201808619Q-A (SG)
Title: Nucleic acid-polypeptide compositions and uses thereof
Inventor: GEALL ANDREW JOHN
IPC: A61K31/712
Filed: 2017-03-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization IIIM 1101111 0 HEIN HO 11111 01E010 1111111110111111101111101111 MI International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/173408 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: (US). BALU, Palani; 21856 Dolores Avenue, Cupertino, C12N 15/113 (2010.01) A61K 47/50 (2017.01) California 95014 (US). BURKE, Rob; 321 Trailview A61K 31/712 (2006.01) Road, Encinitas, California 92024 (US). DARIMONT, (21) International Application Number: Beatrice Diana; 4615 Mount Alifan Drive, San Diego, California 92111 (US). PCT/US2017/025608 (22) International Filing Date: (74) Agent: HOSTETLER, Michael; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, Cali- 31 March 2017 (31.03.2017) fornia 94304 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (30) Priority Data: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 62/316,919 1 April 2016 (01.04.2016) US DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (71) Applicant: AVIDITY BIOSCIENCES LLC [US/US]; HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 10975 North Torrey Pines Road, Suite 150, La Jolla, Cali- KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, fornia 92037 (US). MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (72) Inventors: GEALL, Andrew John; 3571 Calle Palmito, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, Carlsbad, California 92009 (US). DOPPALAPUDI, Ven- TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, kata Ramana; 4168 Twilight Ridge, San Diego, California ZA, ZM, ZW. = 92130 (US). CHU, David Sai-Ho; 8571 Villa La Jolla — Drive, Apt. G, La Jolla, California 92037 (US). CO- (84) Designated States (unless otherwise indicated, for every CHRAN, Michael Caramian; 8683 Via Mallorca, #4, La kind of regional protection available): ARIPO (BW, GH, — Jolla, California 92037 (US). JOHNS, Rachel Elizabeth; GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 11525 Caminito La Bar, #52, San Diego, California 92126 TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [Continued on next page] (54) Title: NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF (57) : Disclosed herein are compositions and pharmaceutical for- FIG. ILA mulations that comprise a binding moi- - ety conjugated to a polynucleic acid = A molecule and a polymer. Also described = herein include methods for treating a = cancer which utilize a composition or a = - - ,„, , ,==„„ ' pharmaceutical formulation comprising binding moiety conjugated to a a poly- = A-B-C A-B-D-C A-D-B-C nucleic acid molecule and a polymer. = = = .4, A-B-D D-A-B-C -Antibody (A) 11 .4 yy • .,== - .siRNA (11) ®-Linker fitt\".~ - PEG (C) GC © 41...;, , ,, d - Endosome escape peptide (D) 71' M A-D-B A-C-B IN 1-1 IN 1-1 0 ei O WO 2017/173408 Al MUNRO DOI 01011M01013010HENHOIREMOVOIMIE TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, — as to the applicant's entitlement to claim the priority of DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, the earlier application (Rule 4.17(iii)) SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, Published: GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). — with international search report (Art. 21(3)) Declarations under Rule 4.17: — with sequence listing part of description (Rule 5.2(a)) — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii))