Patent SG-11201810522U-A (SG)
Title: Anti-cd40 antibodies and their uses
Inventor: HOLLENBAUGH DIANE
IPC: C07K16/28
Filed: 2017-05-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property C.--.` Organization 03 111111H111011111101011101011111001010111111001H0111111111111110111111111111 International Bureau (10) International Publication Number (43) International Publication Date ......P' WO 2017/205742 Al 30 November 2017 (30.11.2017) WIPO I PCT _ (51) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) (71) Applicant: ABBVIE BIOTHERAPEUTICS INC. (72) (74) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/28 (2006.01) A61K 39/395 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/US2017/034681 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, 26 May 2017 (26.05.2017) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, Priority Data: TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/342,417 27 May 2016 (27.05.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, [US/US]; 1500 Seaport Boulevard, Redwood City, Califor- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, nia 94063 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Inventors: HOLLENBAUGH, Diane; 1534 Fordham EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Way, Mountain View, California 94040 (US). YE, Shim- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, ing; 371 Loma Verde Avenue, Palo Alto, California 94306 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (US). COHEN, Diane Sau Mun; 924 Wren Drive, San KM, ML, MR, NE, SN, TD, TG). Jose, California 95125 (US). Agent: HOM, Roy et al.; Dechert LLP, 1095 Avenue of the Americas, New York, New York 10036-6797 (US). — = = = (54) Title: ANTI-CD40 ANTIBODIES AND THEIR USES : The present disclosure provides novel anti-CD40 antibodies, compositions including the antibodies, and methods of making and using the same. encoding CD40 Receptor (SEQ ID NO:40) (from EMBO J, 8(5), 1403-1410 (1989)) the new antibodies, nucleic acids = = = 10 20 30 40 50 MVRLPLQCVL WGCLLTAVHP EPPTACREKQ YLINSQCCSL CQPGQKLVSD 60 70 BO 90 100 CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD 110 120 130 140 150 TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF 160 170 180 190 200 FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLRALVVIPI 210 220 230 240 250 IFGILFAILL VLVFIKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP 260 270 VQETLHGCQP VTQEDGKESR ISVQERQ = = === === = = = _ = = CD40 Ligand (SEQ ID NO:41) (from FEBS Letters, 315 (3), 259-266 (1993)) = = = 10 20 30 40 50 MIETYNQTSP RSAATGLPIS MKIFMYLLTV FLITQMIGSA LFAVYLERRL 60 70 BO 90 100 DKIEDERNLH EDFVFMKTIQ RCNTGERSLS LLNCEEIKSQ FEGFVKDIML 110 120 130 140 150 NKEETKKENS FEMQKGDQNP QIAAHVISEA SSKTTSVLQW AEKGYYTMSN 160 170 180 190 200 NLVTLENGKQ LTVKRQGLYY IYAQVTFCSN REASSQAPFI ASLCLKSPGR 210 220 230 240 250 FERILLRAAN THSSAKPCGQ QSIELGGVFE LQPGASVFVN VTDPSQVSHG 260 TGFTSFGLLK L — 11 rl 71' Ir---- un c> rl , IN ,-1 © (57) rl FIG. 1 [Continued on next page] WO 2017/205742 Al MIDEDIMOMMIDIRMEM00101011EMEDIEHIMEMOIMIE Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt amendments (Rule 48.2(h)) of — with sequence listing part of description (Rule 5.2(a))