Patent SG-11201806992V-A (SG)
Title: Antibodies to tigit
Inventor: TSO J
IPC: C07K16/28
Filed: 2017-03-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111111111011011111111111010111110110111111010111111111110111111110111111 International Bureau .. .... ..Yejd .... ...,,, (10) International Publication Number (43) International Publication Date WO 2017/152088 Al 8 September 2017 (08.09.2017) WIP0 I PCT (51) International Patent Classification: MAD, Omar; 914 Channing Way, Berkeley, CA 94710 A61K 39/00 (2006.01) A61P 37/02 (2006.01) (US). A61K 39/395 (2006.01) C07K 16/28 (2006.01) (74) Agents: SHIEH-NEWTON, Terri et al.; Mintz Levin (21) International Application Number: Cohn Ferris Glovsky and Popeo, P.C., One Financial Cen- PCT/US2017/020719 ter, Boston, MA 02111 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 3 March 2017 (03.03.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (25) Filing Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (26) Publication Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (30) Priority Data: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 62/304,045 4 March 2016 (04.03.2016) US MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/413,025 26 October 2016 (26.10.2016) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (71) Applicants: JN BIOSCIENCES, LLC [US/US]; 320 RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, Logue Avenue, Mountain View, CA 94043 (US). AB- TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, MUNO THERAPEUTICS LLC [US/US]; 914 Channing ZA, ZM, ZW. Way, Berkeley, CA 94710 (US). (84) Designated States (unless otherwise indicated, for every (72) Inventors: TSO, J., Yun; 320 Logue Avenue, Mountain kind of regional protection available): ARIPO (BW, GH, View, CA 94043 (US). TSURUSHITA, Naoya; 320 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, = Logue Avenue, Mountain View, CA 94043 (US). DURA-TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, = [Continued on next page] = (54) Title: ANTIBODIES = = Sall ' , = TO TIGIT el A, (57) : The invention provides monoclonal antibodies that specifically bind to TIGIT. The monoclonal antibodies have the ca- gl pacity for substantial activation of T cells and natural killer cells by inhibiting binding of TIGIT to CD 155. The monoclonal antibodies — nTIL , SLAG CPI can be used for treatment of cancer and infectious disease, among = = 71V F' p ,, Orn407 P loct:o aog '' , 'IN A ''AO-' other applications. plIC a pu, c 4. FSPi = = = — pFCm40:' roCD155 = Sall SPel Ago Eagl = —I CIGIT o ^I = C1IV-F pFCm404 p lactoroase SV40 P EP,40-; 11 pi1C, or .4 p are I M , s p C GC © N kr) FIG.1 ,—, IN ,—, © N O WO 2017/152088 Al MIDEDIMOMOIDEIR0101311101011MMODEVOIMIE DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, before the expiration of the time limit for amending the LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, claims and to be republished in the event of receipt of SI, SK, SM, TR), OAPI GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (BF, BJ, CF, CG, CI, CM, GA, — amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) Published: — with international search report (Art. 21(3))