Patent AU-2013205238-B2 (AU)
Title: Heterocyclic compounds and uses thereof
Inventor: CASTRO ALFREDO C
IPC: A61K31/47
Filed: 2013-04-03
Granted: 2015-12-10
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCI) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/154878 Al 17 October 2013 (17.10.2013) WI POI PC T (51) International Patent Classification: A.; 94 Jaques Street, Somerville, MA 02145 (US). C07D 401/12 (2006.01) C07D 413/12 (2006.01) TREMBLAY, Martin, R.; 47 Heywood Ave, Melrose, C07D 417/12 (2006.01) C07D 471/04 (2006.01) MA 02176 (US). C07D 487/04 (2006.01) C07D 495/04 (2006.01) (74) Agents: INSOGNA, Anthony, M. et al.; Jones Day, 222 C07D 401/14 (2006.01) A61K 31/517 (2006.0l) East 41st Street, New York, NY 10017-6702 (US). C07D 217/24 (2006.01) A61P 35/00 (2006.01) C07D 403/14 (2006.01) A61P 3 7/00 (2006.01) (81) Designated States (unless otherwise indicated, for ever (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/(S2013/035069 AO, AT, AU, AZ, BA, BB, BG, BL, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, 3 April 2013 (03.04.2013) HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (25) Filing Language: English ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (26) Publication Language: English NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (30) Priority Data: TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, 61/622,259 10 April 2012 (10.04.2012) US ZM, ZW. 61/713,404 12 October 2012 (12.10.2012) US (84) Designated States (unless otherwise indicated, for every (71) Applicants: INFINITY PHARMACEUTICALS, INC. kind of regional protection available): ARIPO (BW, GH, [US/US]; 780 Memorial Drive, Cambridge, MA 02139 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (US). INTELLIKINE LLC [US/US]; 10931 N. Torrey UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Pines Road, Suite 103, La Jolla, CA 92037 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors: CASTRO, Alfredo, C.; 43 Wildwood Street, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Winchester, MA 01890 (US). CHAN, Katrina; 38835 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Hayes Street, Fremont, CA 94536 (US). EVANS, Cather- TR), OAPI (BE, BJ, CE, CG, CI, CM, GA, GN, GQ, GW, ine, A.; 83 Jaques Street, Somerville, MA 02145 (US). ML, MR NE, SN, TD, TG). JANARDANANNAIR, Somarajannair; 111 Locust St., Published: Apt. Th-78, Woburn, MA 01801 (US). LESCARBEAU, ith international search report (Art. 21(3) Andre; 99 Porter Street #1, Somerville, MA 02143 (US). LI, Liangsheng; 8155 Cargill Avenue, Apt. 39, San Diego, - before the expiration of the time limit for amending the CA 92122 (US). LIU, Tao; 15 Sherbone Circle, Ashland, claims and to be republished in the event of receipt of MA 01721 (US). LIU, Yi; 4841 Barlow Landings Cove, amendments (Rule 48.2(h)) San Diego, CA 92130 (US). REN, Pingda; 5534 Haven ridge Way, San Diego, CA 92130 (US). SNYDER, Daniel, (54) Title: HETEROCYCLIC COMPOUNDS AND USES THEREOF (57) Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including P13 kinase activity, and com pounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.