baber/WOPTO huggingface dataset:
Patent CA-2437218-A1 (CA)
Inventor: WOLFMAN NEIL M
IPC: A61K35/76
Filed: 2002-02-08
Abstract: La présente invention concerne des propeptides modifiés et stabilisés de protéines de facteur de différentiation de croissance, tels que GDF-8 et la protéine-11 morphogénétique osseuse. Cette invention concerne aussi des techniques de préparation et d'utilisation de ces propeptides modifiés destinés à prévenir ou à traiter des pathologies chez l'homme ou l'animal pour lesquels une augmentation des tissus musculaires pourrait être bénéfique. Ces pathologies comprennent les pathologies musculaires ou neuromusculaires (telles que la sclérose latérale amyotrophique, la dystrophie musculaire, atrophie musculaire, les maladies respiratoires obstructives et congestives, le syndrome de l'amyotrophie, la sarcopénie ou la cachexie), les maladies ou les pathologies du métabolisme ( telles que le diabète de type 2, le diabète sucré non insulino-dépendant, l'hyperglycémie ou l'obésité), les pathologies du tissu adipeux (telles que l'obésité) et les maladies dégénératives osseuses (telles que l'ostéoporose).
Patent CA-2437486-A1 (CA)
Title: Operatory water disinfection system
Inventor: PRINSEN PHILIP M
IPC: A61L2/24
Filed: 2002-02-14
Abstract: The ozone appliance for the professional dental office and other medical applications introduces dissolved ozone into dental and surgical operatory water lines (21). This dissolved ozone can not only disinfect water and water lines (21); it can also reduce gum bleeding, gingivitis, bad breath, teeth stains and oral bacteria. Additionally, it can aid in wound disinfection in surgery and attack microbial contamination of water from dental and surgical operatory water lines (21) and attached hand pieces (61) and dispensing devices. Further, a unit connected to operatory water lines (21) can give an audible (46) or other alarm (47) if the water becomes unsafe.
Patent CA-2438936-A1 (CA)
Title: Truck mounted rotating broom system
Inventor: RUSH JOHN CONAWAY SR
IPC: E01H5/09
Filed: 2003-08-29
Abstract: A rotating broom system to be installed on the front of a self-propelled vehicle such as a truck used for the high speed sweeping and removal of snow or debris from paved surfaces such as airport runways assembly has two major components: a rotating broom drive assembly, and a support structure. The rotating broom assembly is connected to the support structure using a non-rigid connection.
Patent CA-2438977-A1 (CA)
Title: Appareils de diffusion nasale comprenant un mecanisme empechant la diffusion
Inventor: DJUPESLAND PER GISLE
IPC: A61M15/08
Filed: 2002-02-26
Abstract: L'invention concerne un appareil de diffusion nasale et un procédé de diffusion d'une substance dans une cavité nasale d'un sujet. L'appareil de diffusion nasale comprend un embout qui s'ajuste sur la narine d'un sujet, une unité d'application de substance afin d'amener ladite substance à diffuser par l'embout et un mécanisme empêchant la diffusion par l'embout jusqu'au moment où l'embout est correctement ajusté sur la narine du sujet.
Patent CA-2439212-A1 (CA)
Inventor: GELLMAN BARRY N
IPC: A61B17/34
Filed: 2002-03-07
Abstract: A medical sling (20) made from material that is suitably shaped for use in a medical application has sides (30, 32), portions of which are smoothed to prevent abrasion of surrounding tissue.
Patent CA-2442014-A1 (CA)
Title: Two-component spray gun with solvent flush/blend
Inventor: WISNIEWSKI RALPH A
IPC: B05B7/12
Filed: 2003-09-22
Abstract: A dispensing system for a plural component mixture includes a dispensing device, a first container which may or may not be flexible, and separate flexible second containers for each of the components. The second containers are adapted to be placed within the first container. The first container is adapted to be held by an operator during dispensing of plural component mixture from the dispensing device. Separate conduits are coupled between the second containers and the dispensing device. The dispensing device includes a passageway for the passage of each respective component through the dispensing device. Each passageway includes a valve. An actuator controls the valves, thereby controlling the passage of the respective components through the dispensing device. A second valve is coupled in the conduits between the respective components' sources and the dispensing device. The second valve includes an inlet port for each component, an equal number of outlet ports, and an inlet port for a material for flushing the plural components from at least portions of their respective conduits and the mixed plural components from the dispensing device. The second valve has a first state in which each inlet port for a respective one of the plural components is coupled to an outlet port to provide the plural components to the dispensing device when the valve means is in the first state. The second valve also has a second state in which the inlet port for the material for flushing the plural components from at least portions of the respective conduits and the mixed plural components from the dispensing device is coupled to the outlet ports.
Patent CA-2442064-A1 (CA)
Title: G-protein coupled receptors
Inventor: BURFORD NEIL
IPC: A61P3/10
Filed: 2002-03-29
Abstract: The invention provides human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of GCREC.
Patent CA-2443499-A1 (CA)
Inventor: BONJA JEFFREY A
IPC: G02B6/36
Filed: 2002-04-03
Abstract: L'invention concerne un système conçu pour positionner au moins une fibre optique, qui comporte une plaque dont la grande surface définit un trou destiné à recevoir une fibre optique. Un ressort, posé sur la plaque, est installé au moins partiellement à l'intérieur du trou de manière à y positionner la fibre optique et/ou on utilise des plaques additionnelles pour positionner ladite fibre optique.
Patent CA-2446596-A1 (CA)
Inventor: MCGUCKIN JAMES F JR
IPC: A61F2/06
Filed: 2001-11-30
Abstract: L'invention concerne un dispositif vasculaire constitué d'une pluralité d'éléments de contact avec le vaisseau et d'une soupape. Le dispositif peut passer d'une position d'insertion affaissée ayant un premier diamètre à une seconde position déployée ayant un second diamètre supérieur au premier. La pluralité d'éléments de contact avec le vaisseau sont orientés vers l'extérieur du dispositif de façon qu'ils entrent en contact avec la paroi interne d'un vaisseau lors du passage du dispositif à la seconde position déployée, en tirant la paroi interne du vaisseau radialement vers l'intérieur lorsque le dispositif passe de la seconde position déployée à une première position déployée ayant un troisième diamètre supérieur à celui du premier diamètre et inférieur à celui du second diamètre. Dans la première position déployée, la soupape passe d'une position ouverte qui laisse le sang circuler à une position fermée qui stoppe l'écoulement sanguin.
Patent CA-2447020-A1 (CA)
Title: The use of 4-aminopyridine derivatives for the treatment of mglur5 receptor mediated diseases
Inventor: WICHMANN JUERGEN
IPC: A61P25/28
Filed: 2002-05-16
Abstract: This invention relates to 4-aminopyrimidine derivatives of the general formula (I) wherein R1, R2, R3 and R4 have the signifiances defined in the specification and their pharmaceutically acceptable salts. The invention further relates to the preparation of such compounds, to medicaments containing such compounds and to their use for the prevention or treatment of mGluR5 receptor mediated disorders.
Patent CA-2447511-A1 (CA)
Title: Increased volatile removal during solid phase processing of nylon 6 by temperature programming
Inventor: ALSOP ALBERT W
IPC: C08G69/16
Filed: 2002-05-29
Abstract: Process for increasing the molecular weight of nylon 6 while reducing its content of caprolactam and other volatiles by a two-staged heating process.< /SDOAB>
Patent CA-2447912-A1 (CA)
Title: Accessoire pour stomie
Inventor: HAGSTROEM PER
IPC: A61F5/445
Filed: 2002-05-21
Abstract: La présente invention concerne un sac de réception jetable comprenant des parois avant et arrière, scellées l'une à l'autre le long du rebord ; et pourvues d'une ouverture d'entrée. Ce sac est recouvert d'une feuille poreuse qui revêt une de ses surfaces ou les deux. Ce revêtement est fixé à la paroi ou aux parois de ce sac par soudage le long du bord et dans des emplacements discrets sur la surface du revêtement. Ce sac présente une meilleure performance en matière de facilité de nettoyage sans risque de pliure ou de déchirement, et possède des propriétés améliorées en ce qui concerne l'aération de l'humidité pour éviter les problèmes de peau.
Patent CA-2448590-A1 (CA)
Title: A method of manufacturing an optical fiber ribbon, and an optical fiber ribbon
Inventor: FOURNIER JEROME
IPC: C03C25/1065
Filed: 2003-11-07
Abstract: The present invention relates to a method of manufacturing an optical fiber ribbon (100) comprising the following steps: arranging N groups of optical fibers so that the fibers in any one group are disposed in the same plane (P), applying a first layer of a first liquid resin settable under the action of UV type radiation onto each group of optical fibers to form first casings, applying a second layer of a second liquid resin settable under the action of UV type radiation disposed to link together the adjacent first casings, and applying a single irradiation step to the second layer and the first layers using UV type radiation in order to form the first matrices and to form the "link" second matrix.
Patent CA-2449909-A1 (CA)
Inventor: CHENG C YAN
IPC: C07K7/08
Filed: 2002-06-19
Abstract: L'invention concerne des contraceptifs masculins renfermant un peptide et des analogues de celui-ci possédant une séquence d'acide aminé correspondant au second domaine extracellulaire d'une occludine mammifère. Les peptides peuvent être liés à un excipient ciblant des cellules testiculaires, de préférence une hormone stimulant le follicule modifiée. L'invention concerne également des procédés de fabrication d'un tel contraceptif et un procédé d'utilisation associé.
Patent CA-2451238-A1 (CA)
Inventor: DOI TAKESHI
IPC: C07D263/32
Filed: 2002-06-27
Abstract: L'invention concerne un composé représenté par la formule générale suivante (1), (dans laquelle A représente une liaison simple ; C = C, CONH ou NHCO : W représente carbone ou azote ; X représente CH, azote, oxygène ou soufre ;Y représente CH, CHR?1¿, azote, oxygène, soufre ou NR?2¿ ; Z représente azote, oxygène, soufre, CH ou NR?3¿ ; m est 1 ou 2 ; n est un nombre entre 1 et 5 et R?1¿, R?2¿ et R?3¿ représentent chacun hydrogène, alkyle inférieur, alkyle inférieur substitué par hydroxy, alkyle inférieur substitué par alcoxy inférieur, aryle, alkyle inférieur substitué par aryle ou alkyle inférieur substitué par hétéroaryle, à condition qu'un ou deux éléments parmi W, X, Y et Z sont des hétéroatomes), un sel d'addition acide dudit composé, ou un hydrate du composé ou de son sel, ainsi qu'un médicament contenant ce composé ou son sel. Ledit composé (1), qui présente une activité inhibitrice contre l'adhésion cellulaire et l'infiltration cellulaire, peut être utilisé contre l'allergie, l'asthme, le rhumatisme, l'artériosclérose, l'inflammation, etc.
Patent CA-2451261-A1 (CA)
Title: Method and apparatus for conducting total liquid ventilation with control of residual volume and ventilation cycle profile
Inventor: PRAUD JEAN-PAUL
IPC: A61M16/00
Filed: 2003-11-27
Abstract: A method of applying total liquid ventilation to a patient according to a ventilation cycle including inspiration and expiration profiles, comprises supplying oxygenated liquid to the lungs of the patient, withdrawing liquid from the patient's lungs, and controlling independently supply of oxygenated liquid to the patient's lungs and withdrawal of liquid from the patient's lungs. This supply and withdrawal independent control comprises producing a ventilation cycle having independently controlled inspiration and expiration profiles. To carry out the method, a total liquid ventilator system comprises an inspiration pump for supplying oxygenated liquid to the lungs of the patient, an expiration pump for withdrawing liquid from the patient's lungs, and a ventilation cycle control means. The ventilation control means comprises first and second pump controllers connected to the inspiration and expiration pumps, respectively, to control independently these inspiration and expiration pumps in order to produce a ventilation cycle having independently controlled inspiration and expiration profiles.
Patent CA-2455985-A1 (CA)
Title: Therapeutic inhibitor of vascular smooth muscle cells
Inventor: GRAINGER DAVID J
IPC: A61P9/08
Filed: 1994-05-12
Abstract: Sustained release dosage forms of TGF-beta activators and TGF-beta production stimulators are employed to maintain or increase vessel lumen diameter in a diseased or injured vessel of a mammal. Conditions such as restenosis following angioplasty, vascular bypass grafts, transplanted organs, atherosclerosis or hypertension are characterized by a reduced vessel lumen diameter. In a preferred embodiment of the invention, TGF-beta activators and production stimulators inhibit abnormal proliferation of smooth muscle cells. Free TGF-beta activators or production stimulators that are not characterized by an undesirable systemic toxicity profile at a prophylactic dose may be used in conjunction with the sustained release dosage forms described herein for prophylactic purposes with respect to disease and trauma states involving proliferation and/or migration of vascular smooth muscle cells over time.
Patent CA-2456721-A1 (CA)
Inventor: BAUDIER PHILIPPE
IPC: A61P11/06
Filed: 2002-07-31
Abstract: Pharmaceutical composition for inhalation, containing as active ingredient effective amounts of salmeterol or a physiologically salt of salmeterol or a solvate thereof, and budesonide or a therapeutically salt of budesonide or a solvate thereof, wherein the molecular ratio of salmeterol component to budesonide component is in the range 1:2 to 1:50, together with a pharmaceutically acceptable carrier.
Patent CA-2459115-A1 (CA)
Inventor: MASLOV BORIS
IPC: H02K11/00
Filed: 2002-09-24
Abstract: A rotary electric motor is formed within a cylindrical rotor housing structu re that surrounds an annular stator ring. The permanent magnet rotor is configured in an annular ring coaxial with, and outside of, the stator. The stator ring contains a plurality of wound core segments that are ferromagnetically isolated from each other. The core segments are secured to a rigid skeletal structure that is centrally fixed to a stationary shaft. The stator support structure is formed of spine members that extend radially awa y from the center. U-shaped plates at the outer ends of the spine members enga ge adjacent pair of stator segments. Within the inner periphery of the stator ring, space is provided within which motor control circuitry and battery pow er supply may be incorporated.
Patent CA-2461047-A1 (CA)
Title: Cook time control system for convection cooking appliance
Inventor: BOYER MARK A
IPC: F24C7/08
Filed: 2004-03-16
Abstract: A cooking appliance employing rapid cook technology includes a controller which calculates rapid cook times from conventional cooking times input by a user. That is, for relatively long convection cooking cycles, such as a convection roasting mode, after a user enters a standard radiant cooking time into a control panel, an electronic controller subtracts a certain percentage, preferably 25%, off of the standard time to establish a rapid cook time. In one preferred embodiment, the rapid cook time is presented in a display and used as the actual cook time for the cooking operation. In another preferred embodiment, the standard cooking time is established for the cooking operation, but the user is signaled to check the food when the rapid cook time expires.
Patent CA-2462404-A1 (CA)
Title: Amplification of t cells from human cord blood in serum-deprived culture stimulated with stem cell factor, interleukin-7 and interleukin-2
Inventor: SANCHEZ MASSIMO
IPC: A61K35/14
Filed: 2004-03-30
Abstract: The present invention relates to a method of ex vivo amplification of neonatal T cells from umbilical cord blood which comprises obtaining light density mononuclear cells from a sample of umbilical cord blood and then culturing said light density mononuclear cells in a serum-deprived culture medium supplemented with various cytokine combinations. Particularly, there are reported the effects exerted by cytokine combinations including stem cell factor (SCF), interleukin-7, interleukin-4 and interleukin-2, on the amplification of T cells from cord blood mononuclear cells cultured for 10-11 days under serum-deprived conditions. Of all the combinations investigated, SCF plus interleukin-7 sustained the best fold increase (FI) of total nucleated cells (FI=6.4~1.17), amplifying preferentially CD4+ over CD8+ T cell subsets (FI=4.72~0.79 vs 2.73~1.2, respectively, p<0.05). The addition of interleukin-2 to this combination did not significantly increase the total number of cells generated (FI=7.4~2.27) but allowed preferential amplification of CD8+  over CD4+ T cells (FI=6.04~0.14 vs 1.67~0.6, respectively, p<0.05). Single strand conformation polymorphism analysis of the T-cell receptor V.beta.-chain rearrangements expressed by the expanded T cells indicated that the complexity of the T-cell repertoire had increased after 10 days of culture in the presence of SCF and IL-7. Interestingly, a modest expansion (FI=8.67~1.5) of myeloid progenitor cells was also observed in these cultures. These results indicate that it is possible, by modulating the cytokines added to the cultures, to expand specific T cell subsets for adoptive immunotherapy without lousing myeloid progenitor cells necessary for neutrophil recovery after cord blood transplantation.
Patent CA-2464346-A1 (CA)
Title: Water-soluble polymer conjugates of retinoic acid
Inventor: CHARAN CHATAN K
IPC: A61K47/48
Filed: 2002-10-30
Abstract: The present invention provides water-soluble polymer conjugates of retinoic acid. The conjugates of the invention are prepared by covalent attachment of a water-soluble and non-peptidic polymer such as polyethylene glycol to a retinoid such as retinoic acid. The polymer portion of the conjugate may be linear (i.e., prepared using an end-capped or methoxy PEG or a linear bifunctional PEG), branched or forked. The conjugates of the invention are water soluble, and are, in particular, useful for inhalation therapy of conditions of the respiratory tract responsive to retinoid therapy.
Patent CA-2464826-A1 (CA)
Inventor: YOSHIHARA KIYOTAKA
IPC: C22B26/22
Filed: 2004-04-22
Abstract: A method for grain refinement of magnesium alloy castings includes adding graphite (C) powder and manganese dioxide (MnO2) to a melt of magnesium alloy containing aluminum (AI) and manganese (Mn) to finely divide crystal grains of a cast structure.
Patent CA-2466520-A1 (CA)
Inventor: WALKER SIMON
IPC: A47C7/62
Filed: 2004-05-11
Abstract: A seating bracket for connection to a base having a top surface and a vertical side surface to support a seat and a back joist adjacent to the seat. The bracket may include a generally horizontal top portion for supporting the seat and a generally horizontal bottom portion for connection to the top surface of the base. First and second side portions may extend between and be connected to the top and bottom portions and may support the top portion above the bottom portion. The first and second sides may both be inclined with respect to vertical. Upper and lower back joist support portions may be connected to the first side portion adjacent for receiving the back joist and holding the back joist in a generally upstanding position.  The lower back joist support portion may include a downwardly extending portion below the bottom portion for connection with the vertical side surface of the base.
Patent CA-2466542-A1 (CA)
Title: Methods and compositions for use in pet breeding
Inventor: PHEIFFER JOACHIM
IPC: A23K1/16
Filed: 2002-11-25
Abstract: Methods and compositions for use in pet breeding and growth including a method of improving the health status of newborn and young pets by the use of lactoferrin and/or lactoferricin and a feed composition for pets comprising lactoferrin and/or lactoferricin.
Patent CA-2466845-A1 (CA)
Inventor: RAMSDELL FRED
IPC: A61P31/04
Filed: 2002-11-21
Abstract: The invention provides methods for modulating cytokine levels, GM-CSF levels and the immune system using CD83 nucleic acids, CD83 polypeptides, anti-CD83 antibodies and factors that influence CD83 activity or expression. The invention also provides mice having a mutant CD83 gene and mice having a transgenic CD83 gene, which are useful for defining the role of CD83 in the immune system and for identifying compounds that can modulate CD83 and the immune system.
Patent CA-2467135-A1 (CA)
Inventor: HUNTER KIPPLAN D
IPC: B32B5/28
Filed: 2004-05-13
Abstract: A composite laminate structure formed from at least one high-strength, high- stiffness fiber-resin composite structural lamina laminated to at least one fiber-resin composite damping lamina, wherein the resin matrix of the structural lamina resides below its glassification temperature (T g) and wherein the resin matrix of the damping lamina resides above its glassification temperature during normal use temperatures, thereby providing a high-strength laminate with improved damping properties.
Patent CA-2467362-A1 (CA)
Inventor: CLEVELAND TERRI PEARTREE
IPC: E05G1/04
Filed: 2002-11-12
Abstract: A fire-resistant container (10) for use as a safe, formed of steel and lined on its inner surface with a composition comprising insulative and intumescen t materials, preferably mineral wool insulation (40) and hydrated sodium silicate fiberboard (42), respectively. Preferably, an air space (46) is als o provided between the fire-resistant materials and the wall. A hinged door (1 4) of the container is fitted with fire-resistant materials in similar fashion to the container walls, and the door's jamb (18) is gasketed in intumescent material. Within the container, an inner wall is formed of a fire-resistant material such as gypsum board (48). A fire-resistant container in accordance with the invention meets Underwriters Laboratories Standard 72 and is suitab le for storage of paper documents, firearms, and other valuables.
Patent CA-2469145-A1 (CA)
Title: Modular point detector for railroad track switch
Inventor: BRUSHWOOD DANIEL
IPC: B61L5/00
Filed: 2002-10-01
Abstract: A modular sensor apparatus (48,52) for detecting the location of a movable track point includes a primary sensor (132) and a secondary sensor (136) disposed on a sensor mount (128) that is movable with respect to a frame (96 ) that is mounted on a switch machine. The secondary sensor (136) is offset fr om the primary sensor (132) in order to permit the secondary sensor (136) to detect the need for imminent readjustment of the track point prior to the ti me at which the track point becomes maladjusted and in need of immediate readjustment. The sensor mount (128) is threadably adjustable with respect t o the frame (96), whereby once the primary sensor (132) has detected the position of the movable track point when it is disposed against a fixed stoc k rail, the sensor mount (128) can be moved a fixed threshold distance by rotating a thumbwheel (160) a fixed number of turns.