baber/WOPTO huggingface dataset:
Patent CR-20180199-A (CR)
Title: Acetamida tienotriazolodiazepinas y usos de las mismas
Inventor: TANAKA MINORU
IPC: C07D495/14
Filed: 2016-09-09
Abstract: La presente invención proporciona compuestos de Fórmula (I), y composiciones farmacéuticas de los mismos. Los compuestos de Fórmula (I) son moléculas de unión de bromodominios y/o proteínas que contienen bromodominios (por ejemplo, proteínas de bromodominio y extra terminal (BET)). También se proporcionan métodos, usos y kits que usan los compuestos y las composiciones farmacéuticas para inhibir la actividad (por ejemplo, la actividad aumentada) de los bromodominios y/o las proteínas que contienen bromodominio y para tratar y/o prevenir en un sujeto enfermedades asociadas con los bromodominios o las proteínas que contienen bromodominio (por ejemplo, enfermedades proliferativas, enfermedades cardiovasculares, infecciones víricas, enfermedades fibróticas, enfermedades metabólicas, enfermedades endocrinas y envenenamiento por radiación). Los compuestos, las composiciones farmacéuticas y los kits también son útiles para la contracepción masculina.
Patent CR-20180607-A (CR)
Title: Elementos reguladores de plantas y sus usos
Inventor: CHITTOOR JAISHREE M
IPC: C12N15/82
Filed: 2017-05-22
Abstract: La invención proporciona moléculas de ADN recombinante y construcciones, así como sus secuencias de nucleótidos, útiles para modular la expresión génica en las plantas. La invención también proporciona plantas transgénicas, células de plantas, partes de plantas y semillas que comprenden las moléculas de ADN recombinante unidas de forma operativa a las moléculas de ADN transcribible heterólogas, como también los métodos de su uso.
Patent EC-SP044994-A (EC)
Title: Derivados de diarilcicloalquilo, procedimientos para su preparacion y su utilización como agentes activadores del ppar
Inventor: GLOMBIK HEINER
IPC: C07D263/32
Filed: 2004-02-27
Abstract: El invento se refiere a derivados de diarilcicloalquilo, así como a sus sales fisiológicamente compatibles y derivados funcionales fisiológicamente. Se describen compuestos de fórmula (I), en donde los radicales tienen los significados indicados, así como sus sales fisiológicamente compatibles y un procedimiento para su preparación. Los compuestos tienen propiedades de disminución del nivel de lípidos y/o triglicéridos y se adecuan, por ejemplo, para el tratamiento de alteraciones del metabolismo de los lípidos, de la diabetes del tipo II y del síndrome X.
Patent FI-20001135-A (FI)
Inventor: NISKANEN HEIKKI
IPC: B65H19/30
Filed: 2000-05-12
Abstract: The invention relates to a separator 10 for web coils for a machine processing a paper, pulp or similar flexible, continuous web, said machine comprising a part for coiling web coils 1, or supporting rollers 2, a rolling support 3 and a coil stop 4. According to the invention, the separator 10 for the web coils is adjustable in length, preferably elastic or extendible in the crosswise direction or the CD direction relative to the rolling direction or the MD direction, whereby the web coils 1 are separated from each other in the CD direction on the separator 10 by extension of the separator 10 for the coil webs. <IMAGE>
Patent GB-1054254-A (GB)
IPC: G01G11/08
Abstract: 1,054,254. Automatic control of conveyers. WIBAU WESTDEUTSCHE INDUSTRIE-UND STRASSEN-BAU-MASCHINEN G. m. b. H. Aug. 7, 1963 [Sept.24, 1962], No.31234/63. Heading G3R. [Also in Division G1] In an apparatus for continuously discharging bulk material at a constant rate or mixing in constant proportions, material is discharged from a hopper 1 by an electrical vibrator 2 on to a pivoted weigh belt conveyer 3 which is held in equilibrium, when the correct quantity of material is on the belt, by a counterweight 4. An electromagnetic detector 6 detects any unbalance and a signal therefrom is fed to a control device 7 (not described) which adjusts the magnitude of the vibrator energizing voltage U 2  to correct the discharge rate from the hopper. Several such units may be used each feeding a predetermined proportion of a mixture.
Patent GB-1054422-A (GB)
IPC: H01L23/48
Abstract: 1,054,422. Semi - conductor devices. SIEMENS-SCHUCKERTWERKE A.G. March 11, 1964 [March 16, 1963], No. 10391/64. Heading H1K. In a semi-conductor arrangement comprising a semi-conductor body having at one face a conductive porous connecting body of sintered material, the portion of the connecting body adjacent the semi-conductor body has a smaller cross-sectional width than the semi-conductor body while a second portion of the connecting body remote from the semi-conductor body has a greater cross-sectional width than the semi-conductor body. As shown, Fig. 1, a gold foil 2 is placed on one face of a P-type silicon wafer 1 which is separated from a molybdenum carrier plate 4 by an aluminium foil 3. This assembly is placed in graphite powder and alloyed by heating under pressure to form a rectifier. The edge of the wafer 1 may be etched and oxidized. Contact to the alloyed gold foil 2 is made by a sintered body 6 of molybdenum and/or tungsten containing nickel and having the cross-section illustrated A silver layer 5 may be applied to the face of body 6 which may then be joined to electrode 2 using a thermo-compression bonding technique. The surfaces of the recess between plate 4 and body 6 may be coated with a lacquer or the recess may be filled with a hardenable plastic which may contain a filler. The gold foil 2 may contain antimony and the molybdenum place 4 may contain nickel and may have a layer of nickel electroplated or vapour deposited on to the face to which the wafer is attached. Alternatively plate 4 may be of steel containing nickel and cobalt or may be replaced by a member similar to member 6, and both the plate 4 and member 6 may contain 50% silver to increase their thermal conductivities. Layer 5 on member 6 may also be of gold, copper. nickel or a metal alloyable with gold. The semi-conductor body may also be of germanium. silicon carbide or a III-V or II-VI compound, and the doping wafers 2 and 3 may be of indium and lead-arsenic alloy. The device may be enclosed in a housing, Fig. 2 (not shown), of the kind described in Specification 870,895 in which face 8 of plate 4 is separated from a cooling stud by a silver foil and body 6 is joined to a copper pin which is acted upon by dished springs to press body 6 into contact with electrode 2. The device may also be enclosed in a flat housing, Fig. 3 (not shown), comprising an insulating ring to the surfaces of which are attached metal discs which contact the faces 7 and 8 of the device located between them.
Patent GB-1231412-A (GB)
IPC: A61K31/57
Filed: 1968-04-19
Abstract: 1,231,412. Contraceptive compositions. SCHERING A.G. 19 April, 1968 [19 April, 1967], No. 18661/68. Heading A5B. A contraceptive composition in unit dosage form for injection or implantation and which is free from oestrogens comprises a carrier and a gestagen (progestational hormone) other than progesterone, the gestagen being present in an amount having an activity, as measured by its action on the cervical mucus, corresponding to that produced by from 1 to 20 mg of 19-nor-17α-hydroxy progesterone caproate when administered in the same way. In addition to this compound, suitable gestagens are progesterone-3-enol-esters and the esters of 6α- methyl-; 6-methyl-6-dehydro; 6-chloro (or fluoro)-6-dehydro; 6-chloro (or fluoro)-6-debydro-16α (or #)-methyl-; 6 16-dimethyl-6-dehydro-; 6-methyl (or chloro)-6-dehydro-16- methylene and 1,2-methylene-6-chloro (or fluoro)-6-dehydro-17α-hydroxy progesterones and 17α-ethynyl-18-homo-19-nor testorterone and its esters. Other less suitable hormones are also mentioned. Typical compositions are oily solutions for injection which may comprise a solubility promoter, e.g. benzyl benzoate.
Patent GB-1232005-A (GB)
IPC: H01T1/06
Filed: 1967-07-19
Abstract: 1,232,005. Spark gaps. SWITCHGEAR & EQUIPMENT Ltd. 17 July, 1968 [19 July, 1967], No.33151/67. Heading H1D. [Also in Division H2] An electric spark gap device includes one or a series of spark gaps 16a, 16b, 16c having the opposing electrodes supported within a heatabsorbing, electrically insulating container 10 which provides lateral clearance from the adjacent ends of the electrodes, and means 33, 33a &c. for producing a magnetic field across the, or each spark gap to divert a spark generated in the gap laterally across the said clearance into contact with the container so as to be ruptured by a combination of heat-absorption by the container and the lengthening of the path of the spark. The end electrodes 14 and 15 may be attached to end caps 12, 13 sealing the envelope and may be adjustable. The corrugations in the envelope may be formed by a helical groove. An alternative form of electrode (Fig. 2, not shown) comprises a bent wire which may be covered by a cap. Each intermediate electrode 20, 21 is set in a conductive disc 22 held in position by a screw extending through the envelope 10 and locked in position by a nut 24. Voltage grading resistors 25, 26 and 27 and capacitors 30, 31 and 32 are connected across the gaps to form a surge diverter. In an alternative diverter (Fig. 6, not shown) an assembly similar to that shown is mounted between two pairs of non-linear resistors in an envelope provided with a non-return valve through which an inert gas is introduced. Three surge diverters may be connected in a 3-phase circuit (Fig. 8, not shown) and may be mounted in association with a 3-phase transformer on a distribution pole.
Patent GB-1233294-A (GB)
IPC: B21D1/02
Filed: 1969-03-12
Abstract: 1,233,294. Straightening. I. UNGERER. 12 March, 1969 [28 March, 1968], No. 13151/69. Addition to 1,230,559. Heading B3E. A sheet and strip-flattening machine comprises a frame 1 having vertical guideways spaced apart, a yoke 5 disposed between them and in engagement with said guideways, a set of lower rolls 3 carried by said yoke, a set of upper rolls 2 carried by said frame, guide means 6 extending on opposite sides of said frame, said yoke conforming to and resting on said guide means, adjusting members which carry said guide means, a saddle 16 on which said adjusting members are mounted for adjustment of said guide means relative to said saddle and a wedge 17 interposed between said saddle and said frame to adjust said saddle at high speed in a vertical direction. The guide means 6 has inclined surfaces 7 supported on wedges 9 actuated by a transverse screw 8 having screwthreads of opposite hand to provide vertical adjustment. The screw 8 is longitudinally displaceable by screw-members 12, 13 to tilt the yoke the wedges 9 being provided with arcuate guideways 15. The wedge 17 is actuated by a pneumatic or hydraulic motor not shown.
Patent GB-1238894-A (GB)
IPC: A61K31/21
Filed: 1968-10-23
Abstract: 1,238,894. #-Guanidino alkanoic acid esters. S. FUJII. 23 Oct., 1968 [24 Oct., 1967 (2)], No. 50414/68. Heading C2C. #-Guanidino alkanoic acid esters of general formula H 2 NC(:NH)NH(CH 2 ) n COOR (in which R is a carboxylbenzyl group which may carry further groups and n is 3, 4 or 5) and their acid addition salts, may be prepared (a) by esterification of the corresponding free carboxylic acids with an alcohol ROH, or (b) by reacting a carboxybenzyl #-amino alkanoate (prepared by conventional esterification) with either S-methylthiourea or cyanamide. The compounds inhibit the hydrolysis of arginine ester by kallikrein and of casein by plasmin, and may be administered in conventional enteral or parenteral forms.
Patent GB-1250771-A (GB)
IPC: A01K1/10
Filed: 1968-01-18
Abstract: 1,250,771. Feeding rack. L. V. EVANS. 18 April, 1969 [18 Jan., 1968], No. 2678/68. Heading A1M. A feeding rack comprises a main frame A, Fig. 1, and sub-frames H' and a horizontally extending frame carrying a canopy F, Fig. 2. In use, the rack is fitted to the side of a barn containing foodstuffs e.g. stacks of bales, and animals can stick their heads through the spaces and between the sub-frames to get at the lowermost bales.
Patent GB-1252028-A (GB)
IPC: F24D3/10
Filed: 1969-04-26
Abstract: 1252028 Central heating systems KAYDON HEATING Ltd 27 July 1970 [26 April 1969] 13051/69 Headings F2G G1F G35 and G28 A manifold which distributes hot water to or receives cold water from heat exchangers in a central heating system comprises a cylindrical pipe 1 which is so configured as to permit an essentially rectilinear laminar flow of water therethrough and having pipes 4 extending from an end wall 3a at least initially in alignment with the pipe 1 to minimize turbulence. The free ends of the pipes are connectable by tubing to the heat exchangers. A second similar manifold may be used in the system.
Patent GB-1253193-A (GB)
IPC: B23Q16/00
Filed: 1970-01-22
Abstract: 1,253,193. Machine tool details. HAHN & KOLB K.G. 22 Jan., 1970 [23 Jan., 1969], No. 3147/70. Headings B3B and B3C. A machine tool for simultaneously working upon a plurality of workpieces, e.g. drilling, comprises an indexable turntable 12 which carries a plurality of work-holders (not shown) and a number of radially feedable tools (not shown) arranged around the turntable, the feed movement of the tools being produced by the rotation of cams 33. The cams are mounted on control shafts 20 which are rotated by an hydraulic motor 21 through a continuously operable central drive 23-26 and which are connected therewith by individual drive members 27-32. The turntable 12 is indexed in equal angular steps by an electric motor 13 driving through a worm and wheel 14, 15 to rotate a sinusoidal faced cam 16 which engages a pin 17 on a star wheel 18. The cam 16 is rotated one revolution for each indexing step. An hydraulic control is provided to drive the motor 21 at three speeds and a common control device is provided to control the three speeds and the indexing of the turntable, the said device including a cam-shaft rotated by a control shaft 20 to actuate switches. The three speeds relate to a cutting feed speed for the tool, a fast feed and retraction speed, and a slow speed effective during the indexing of the turntable. Each cam 33 is divided into sectors (73-76) (Fig. 3, not shown) which govern the tool feed to a dwell period (73) during indexing of the turntable, a fast feed (74) to the workpiece, a cutting speed (75), and a fast retraction (76). At the change over from one sector to another the cam-shaft operates a switch to change the speed of the motor 21 and hence of the rotation of the cam itself. Hydraulic control.-The three speeds of rotation of the motor 21 are achieved by providing two sources of hydraulic pressure, i.e. pumps 37 and 47, one pump providing the cutting speed, the other providing the slow speed and the two combining to produce the fast speed. Solenoid valves 43, 49 are controlled by the cain-shaft and switches previously mentioned. Non- return valves 46, 55, 57, flow regulators 45, 54 and pressure adjusting valves 39, 77 are provided A-solenoid operated shut-off valve 59 is controlled with the indexing of the turntable so that it is open only when the drive to the tools is  on, and so that it shuts off if a fault develops in the indexing of the turntable.
Patent GB-1256618-A (GB)
IPC: C22C32/00
Filed: 1969-07-04
Abstract: 1,256,618. Electric contact material. SIEMENS A. G. July 4, 1969 [July 5, 1968], No. 33925/69. Heading C7A. Material for electric contact members consists of Ag in which up to 20% by weight of at least one finely-divided metal oxide and 3-15% of finelydivided Pb are uniformly incorporated. Suitable metal oxides are CdO, SnO 2 , ZnO, MgO and NiO. Contact members may be produced by pressing powder, sintering in an inert atmosphere, and optionally cold after-pressing. They may be hard soldered direct to carrier metals or alloys.
Patent GB-1257400-A (GB)
IPC: E21B25/00
Filed: 1970-09-17
Abstract: 1,257,400. Boring earth &c. ACKER DRILL CO. Inc. 17 Sept., 1970, No. 44434/70. Heading E1F. A telescopic sub 10 between a drill string D and a core sampler CS prevents drilling fluid causing excessive errosion of a sample of a material overlaid by harder material. The sub comprises a body 11 connected to the string and having a bore 12 with a transverse partition 14; a chamber 15 below the partition and connected to the bore above the partition by passages 20; a hollow piston 25, 30, 29 closed at its upper end, sliding in the bore below the partition and connected to the sampler; a spring 36 urging the piston to the fully extended position; and sets of holes 33, 34 in the piston. When the sub is in the hole without pressure on the sampler flow of fluid to the hole passes through holes 33. During normal drilling flow of fluid to the hole passes through holes 34, and at breakthrough into the material to be sampled the flow is interrupted and increase in pressure of the drilling fluid warns the driller.
Patent GB-1257569-A (GB)
IPC: E02D31/02
Filed: 1969-03-13
Abstract: 1,257,569. Wells etc.; barrier walls in permeable strata. THYSSEN (GREAT BRITAIN) Ltd., SHAFT SINKERS (PTY) Ltd., TAYLOR WOODROW CONSTRUCTION Ltd., and BOART DRILLING & CONTRACTING Ltd. 10 June, 1970 [13 March, 1969], No. 13350/69. Headings E1F and E1H. A waterproof barrier is formed in the ground by fracturing the ground to form cracks and injecting grout into the cracks. A mine shaft is formed by drilling two circles of holes 11 (Fig. 2) fracturing the space between the circles over the depth which the barrier is to. extend and injecting chemical or cement grout into the cracks. The cracks which may be held open by sand may be formed by use of elongated shaped charges, by injecting fluid under pressure, by mechanical wedging, or by water hammer effect. Additional holes 14 are drilled, and cracks 15 are formed and grouted to form a shaft bottom. As shown in Fig. 3 a shaft is sank through impermeable strata to a level 20, holes 21 are drilled and waterproof barriers 22, 23, are formed, the shaft is sunk to a level 24, further holes 25 are drilled and barriers 26, 27 are formed, and the process of drilling, fracturing, grouting and excavating is repeated as necessary. A tunnel may be extended through a permeable layer of the strata by a technique similar to that described with reference to Fig. 3. Before building a dam 40 cut-off curtains 41, 42 are formed by drilling holes 43, fracturing and grouting. (For Figures see next page)
Patent GB-1258302-A (GB)
IPC: G02B5/12
Filed: 1969-03-13
Abstract: 1,258,302. Reflex reflectors. PROJECTEURS CIBIE. March 13, 1969 [March 14, 1968], No.13376/69. Heading G2J. A vertical reflex reflector having a series of polyhedral elements 3 on its rear surface 2 has a front side 1 having faces 4a, 4b inclined at about 2 degrees to the general plane of the front side, or a network of horizontal parallel triangular grooves (5), Fig.3 (not shown), or a network of horizontal parallel grooves (6) of square section, Fig.4 (not shown). The arrangement is such that an incident horizontal light beam h<SP>1</SP> will give a strong reflection at about 20<SP>1</SP> upwards of the horizontal to suit drivers of private cars whose eyes would be about a metre above road level, and also a strong reflection at about 1 degree 30<SP>1</SP> to suit drivers of heavy vehicles whose eyes would be at a much higher level.
Patent GB-1259182-A (GB)
IPC: E21D11/34
Filed: 1969-03-24
Abstract: 1,259,182. Pivotal mine roof support arches. LORENZ-POLYGON-AUSBAU G.m.b.H. 24 March, 1969 [28 March, 1968; 24 May, 1968; 11 Feb., 1969], No. 15378/69. Heading E1E. A mine roof support member 1 is connected to a stilt, see Figs. 2, 5 and 6 (not shown), by a three-piece shackle interconnected by a bolt 12. The central part of the shackle is provided with an elongated aperture 13 to receive the bolt with play and opposed apertured flanges 7 for attachment to the stilt which is additionally located in position by a central flange 7. Each of the outer parts of the shackle is provided with a clamping jaw 10 and a bearing bush surface 9. In a modification, see Fig. 4 (not shown), the outer parts of the shackle are each provided with a socket to receive a bearing part of the central part. For various dimensions and modus operandi the Specification and remaining drawings (not shown), should be referred to.
Patent GB-1265099-A (GB)
IPC: H01H51/28
Filed: 1970-10-14
Abstract: 1,265,099. Electromagnetic switches; electric selectors. SIEMENS A.G. 14 Oct., 1970 [31 Oct., 1969], No. 48717/70. Headings H1L and H1N. Electromagnetic relay sets for use in telephone systems have a plurality of switching devices encapsulated in a protective casing 55 or 104, and each device has a first and second polepiece and an armature 73 or 99 with its movable end between the polepieces and a distance piece to which the armature and polepieces, or carriers thereof, are coupled to set the working gap 103 between the polepieces. The switching devices each have a thrust plate 59, 60 of spring material, at least two armature spring plates 68, 69, 70, 71 equipped with armatures 73 and first polepieces 72 and two contact plates 75, 76 or 102 each with a second polepiece 78. The distance pieces or rods 62 are disposed transversely of the central axis of the grouped system and a base 56 having connecting elements 75 to which the switching devices are attached. The systems of devices are arranged within a casing formed by two bases and a sleeve 55 and are forced into engagement with the sleeve wall through the opposing thrust plates 59, 60 which seat directly against each other (Fig. 12, not shown) or through intervening components such as a polarizing magnet 64. Each pair of superposed devices have a common external energizing circuit comprising a soft iron bridge 80 and coil 81. The divided ends 98 of the spring plates form the movable contacts.
Patent GB-1265906-A (GB)
IPC: F21Y101/00
Filed: 1969-12-12
Abstract: 1,265,906. Lamps. PATENT-TREUHANDGES FUR ELEKTRISCHE GLUHLAMPEN- m.b.H. 12 Dec., 1969 [12 Dec., 1968], No. 60817/69. Heading F4R. An electric lamp comprises a bulb 1 of the incandescent filament or discharge type which is surrounded by a mount made of plastics material and including a reflector 11<SP>1</SP> and a transparent or translucent cover disc 10 inseparably secured together, e.g. by ultrasonic welding. The lamp may be provided with a clamping nut 13 for securing it to an indicator panel and with projections 22, 22<SP>1</SP> for engagement with a printed circuit. Alternatively, a groove (27) may be formed in the stepped portion 11 to engage with one end of a battery housing (29) so that the lamp can serve as the bulb enclosure of a torch. The mount may have cut-outs 14, 15 which expose portions of the bulb base 5, switching being effected by rotating the lamp relative to a U-shaped contact spring 18 so that the spring is brought into and out of contact with the base. The disc 10 may be coloured or formed as a lens. In a modification contact pins (24, 24<SP>1</SP>) are embedded in the plastics mount.
Patent GB-1289606-A (GB)
IPC: F16D55/22
Filed: 1970-05-07
Abstract: 1289606 Disc brakes TOYOTA CHUO KENKYUSHO KK 7 May 1970 [8 May 1969] 21990/70 Heading F2E In a disc brake comprising a rotatable disc 10, a calliper 30 straddling a portion of the periphery of the disc, at least one axially movable piston 70 in the calliper operated by fluid pressure, and a pad 50 of friction material adapted to be pressed by the piston against the disc, there are, to prevent brake squeal, two cylindrical rollers 60 positioned between the opposed surfaces of the piston and pad. The longitudinal axes of the rollers are parallel to the surface of the disc and the rollers are supported in a groove 78 in the piston on pad or in a groove in the piston and the pad. As shown, the piston has projections 76 the heads 77 of which are accommodated in grooves 54 in the pads and the shanks of which pass through slots 53 in the pad backing plates 51 whereby the pads may be assembled in the calliper 30; a bridge 33 prevents upward movement of the pads.