Patent SG-11201906804U-A (SG)
Title: Zwitterionically modified polymers and hydrogels
Inventor: MA MINGLIN
IPC: A61K31/738
Filed: 2018-01-27
Abstract: WO 18/ 14083 4 Al (a) 9 0 Sulrobetsahat , N11, Sulfabetaine-based agar[ easjagatei k, (IV) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT omit VIII °nolo 010 Ho VIII mil olo HIND oimIE (10) International Publication Number WO 2018/140834 Al (51) International Patent Classification: A61K 31/715 (2006.01) A61K 31/738 (2006.01) (21) International Application Number: PCT/US2018/015613 (22) International Filing Date: 27 January 2018 (27.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/451,629 27 January 2017 (27.01.2017) US (71) Applicant: CORNELL UNIVERSITY [US/US]; Center For Technology Licensing At, Cornell University ('ctl'), 395 Pine Tree Road, Suite 310, Ithaca, NY 14850 (US). (72) Inventors: MA, Minglin; Riley-Robb Hall 322, Cornell University, Ithaca, NY 14853 (US). LIU, Qingsheng; Ri- ley-Robb Hall 145, Cornell University, Ithaca, NY 14853 (US). (74) Agent: CHILDS, Carissa, R. et al.; LECLAIRRYAN, A PROFESSIONAL CORPORATION, 70 Linden Oaks, Suite 210, Rochester, NY 14625 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) (54) Title: ZWITTERIONICALLY MODIFIED POLYMERS AND HYDROGELS (57) : The present invention is directed to a polymer of Formu- o la (IV): wherein A, X, Q, Y, Z, ml; m2, m3, kl; and k2 are as described herein and wherein the monomer units of the polymer are the same or different. The present invention also relates to a monomer of Formula (III), wherein R\", Xi , Y 1 , Z 1 ' m4, m5, and m6 are as described herein, and a polymeric network comprising two or more monomers of Formu- la (III). The present invention also relates to a hydrogel comprising any of the polymers and monomers described herein, a capsule comprising the hydrogel, and a method of delivering a therapeutic agent to a subject using the capsule.