baber/WOPTO huggingface dataset:
Patent NZ-718686-A (NZ)
Title: Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
Inventor: HSU ANN
IPC: A61P25/16
Filed: 2016-03-31
Abstract: The invention provides a controlled release oral solid formulation comprising (a) a controlled release component comprising core comprising levodopa and/or an ester of levodopa or salts thereof, wherein the core is coated with a layer of a muco-adhesive polymer and externally coated with a layer of an enteric coated polymer; and (b) an immediate release component comprising levodopa and optionally a decarboxylase inhibitor.
Patent NZ-720499-A (NZ)
Title: Bicalutamide analogs or (s)-bicalutamide as exocytosis activating compounds for use in the treatment of a lysosomal storage disorder or glycogenosis
Inventor: FARRERA-SINFREU JOSEP
IPC: A61K31/167
Filed: 2014-12-19
Abstract: The invention provides a therapy for lysosomal storage diseases and glycogenosis by treatment with (S)-bicalutamide or its analogues, which promote exocytosis, preferably lysosomal exocytosis. The treatment of cells from patients affected by different lysosomal storage disorders with exocytosis activating compounds leads to a decrease in the accumulation of toxic substrate in the lysosomes, thus allowing the treatment, prevention and relief of the symptoms of many lysosomal storage disorders.
Patent NZ-726432-A (NZ)
Title: Syringe with rolling diaphragm
Inventor: BERRY DAVE
IPC: A61M5/315
Filed: 2015-04-24
Abstract: A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with a concave end wall with a plunger engagement portion recessed into a cavity in the wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. A sidewall extends between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm. The plunger engagement portion holds the plunger more securely.
Patent NZ-729042-A (NZ)
Title: Plurimodal release formulation of doxylamine and pyridoxine and/or metabolites or salts thereof
Inventor: VRANDERICK MANON
IPC: A61K9/28
Filed: 2014-08-29
Abstract: A solid oral dosage form comprising a core comprising a doxylamine component and a pyridoxine component coated with an enteric coating is disclosed. The solid oral dosage form further comprises two active ingredient-containing coatings surrounding the enteric coating, the active ingredient-containing coatings being separated from one another by an intermediate coating, and one of the two active ingredient-containing coatings comprising a doxylamine component and being free of a pyridoxine component, and the other of the two active ingredient-containing coatings comprising a pyridoxine component and being free of doxylamine component. Uses of the solid oral dosage form for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP), are also disclosed.
Patent NZ-729633-A (NZ)
Title: Targeted/immunomodulatory fusion proteins and methods for making same
Inventor: GOVINDAPPA NAGARAJ
IPC: C07K14/705
Filed: 2013-03-13
Abstract: The present invention relates generally to the field of generating fusion proteins to be used in cancer therapy. In particular, the present invention provides a method of preparing a therapeutically active antibody-peptide fusion protein, the method comprising; preparing a codon optimized sequence of the fusion protein for expression in Chinese Hamster Ovary (CHO) cells, wherein the antibody-peptide fusion protein comprises a targeting moiety and immunomodulating moiety, wherein the targeting moiety and the immunomodulating moiety are linked by an amino acid spacer selected from SEQ ID NO: 3 or SEQ ID NO: 11, wherein the immunomodulating moiety is TGF-βRII consisting of an amino acid sequence of SEQ ID NO: 4; and wherein the targeting moiety is an Anti-HER2/Neu antibody consisting of heavy chain SEQ ID NO: 1 and light chain SEQ ID NO: 2; Anti-EGFR1 consisting of heavy chain SEQ ID NO: 5 and light chain SEQ ID NO: 6 or anti-CTLA4 consisting of heavy chain of SEQ ID NO: 7 and a light chain of SEQ ID NO: 8, wherein SEQ ID NO: 4 is attached via the amino acid spacer to the C-terminus of SEQ ID NO: 1 or SEQ ID NO: 2 of Anti-HER2/Neu; C-terminus of SEQ ID NO: 5 or SEQ ID NO: 6 of Anti-EGFR1; or C-terminus of SEQ ID NO: 7 or SEQ ID NO: 8 of Anti-CTLA-4; cloning the optimized sequence of said antibody-peptide fusion protein in a host cell capable of transient or continued expression; growing the host cell in a fermentation medium under suitable conditions for growing and allowing the host cell to express the antibody-peptide fusion protein, wherein the fermentation medium comprises a divalent transitional metallic salt, wherein the divalent transitional metallic salt is zinc sulphate hepta hydrate and in amount from 0.3 mM to about 0.4 mM to reduce accumulation of lactate during culturing; and purifying the expressed antibody-peptide fusion protein in an affinity chromatography and optionally checking the bi-specific binding capabilities of the antibody-peptide fusion protein to its targets.
Patent NZ-738559-A (NZ)
Title: Warming tool, warming kit, method for manufacturing warming kit, and warming method using the warming kit
Inventor: MIYAKE KENSAKU
IPC: A41D13/005
Filed: 2015-05-26
Abstract: [Problem] To provide a heat insulating tool with which it is possible to more effectively insulate heat in a human body for a long period of time during emergencies such as disasters, evacuations, etc. [Solution] A warming kit comprising a bag-shaped heat insulating tool (1) having a front surface part (3) and a rear surface part (4) formed from a flexible textile, the top end part (3t, 4t) and both side end parts (3s, 4s) of the peripheral edge sections of the front surface part (3) and the rear surface part (4) being connected, whereby the warming tool is vacuum-packed by the bag to prevent the heating elements from emitting heat prior to the bag being ruptured, and whereby the heat insulating tool is opened on the bottom end side (3b, 4b), wherein the center section of the top end part (3t, 4t) has a neck section (1A) formed large enough to allow the neck of a human body to pass therethrough, the top side of both side end parts (3s, 4s) having arm sections (1B) formed so that the arms of a human body can pass therethrough, and the surface of the front surface part having pockets (6A-6H) for holding heat emitting bodies (100) that emit heat when brought into contact with air.
Patent NZ-741670-A (NZ)
Title: Method for controlling the production of a biocide
Inventor: BARAK AYALA
IPC: C02F1/76
Filed: 2014-02-06
Abstract: A method and apparatus for producing a biocide from a hypochlorite oxidant and an ammonium salt are provided. The method includes monitoring a control parameter to optimize the ratio between the hypochlorite oxidant and the ammonium salt. The control parameter may be oxidation-reduction potential, conductivity, induction or oxygen saturation.
Patent NZ-755967-A (NZ)
Title: A tamper-evident packaging box
Inventor: ZENG XU
IPC: B65D55/02
Filed: 2019-08-01
Abstract: This invention discloses a tamper-evident packaging box, including a box body 10, a hollow cavity 11 in the box body 10, a slidable disk 12 in the hollow cavity 11, a placement table 13 on the slidable disk 12, sliders 14 on a lower end surface of the slidable disk 12, a sliding cavity 28 communicated with the hollow cavity 11 and an outer space, a slidable plate 40 in the sliding cavity 28. The invention is simple in structure and convenient in operation. When a tamper-evident device is not opened, the packaging box can be used normally; after the function of tamper-evident starts, when the packaging box is opened again, an elastic spring of the slidable plate 40 is broken, and the packaging box can be used continuously; however, the slidable plate 40 can not slide automatically any more.
Patent NZ-801152-A (NZ)
Title: Increased 2’-fl production by goats
Inventor: HAANDRIKMAN ALFRED JACQUES
IPC: C12Q1/6876
Filed: 2021-12-10
Abstract: Disclosed is a method of producing goat milk having naturally present 2’-fucosyllactose (2’-FL). The method comprises determining whether a goat is producing 2’-FL, selecting a plurality of goats that produce 2’-FL; and milking the selected goats. Also disclosed is determining whether the goat producing 2’- FL possesses at least one copy of a favourable allele at a SNP and/or has a deletion in the region of the FUT2 gene.
Patent PT-104441-A (PT)
Title: Sensor para determinar a força de impacto da queda de granizo
Inventor: ROCHA JOSE GERARDO VIEIRA
IPC: B32B7/02
Filed: 2009-03-19
Abstract: A PRESENTE INVENÇÃO RELACIONA-SE COM UM DISPOSITIVO METEREOLÓGICO QUE AO SER COLOCADO AO AR LIVRE TEM A CAPACIDADE, NÃO SÓ DE DISTINGUIR OS IMPACTOS CAUSADOS PELA CHUVA DOS CAUSADOS PELO GRANIZO, MAS TAMBÉM DE MEDIR A ENERGIA CINÉTICA, A QUANTIDADE POR UNIDADE DE ÁREA E DE TEMPO E AS DIRECÇÕES HORIZONTAL E VERTICAL ASSOCIADAS À QUEDA DO GRANIZO. O DISPOSITIVO, EM FORMA DE PIRÂMIDE, CONTÉM QUATRO TRANSDUTORES PIEZOELÉCTRICOS (5), UM PARA CADA UMA DAS SUAS FACES. CADA UMA DAS FACES DA PIRÂMIDE ESTÁ ISOLADA ACUSTICAMENTE DAS ADJACENTES E DA BASE, DE MODO QUE AS VIBRAÇÕES CAUSADAS PELOS IMPACTOS RECEBIDOS NÃO SE PROPAGUEM E SEJAM DETECTADOS PELOS OUTROS TRANSDUTORES. UM SISTEMA DE AQUISIÇÃO DE DADOS, CONSTITUÍDO POR UM FILTRO ACTIVO (6) E UM CONVERSOR ANALÓGICO DIGITAL (7) IRÁ LER OS SINAIS PROVENIENTES DOS QUATRO TRANSDUTORES E TRANSMITILOS, SOB A FORMA DIGITAL A UMA UNIDADE DE PROCESSAMENTO, QUE PODE SER UM MICROCONTROLADOR OU UM COMPUTADOR (8). ESTE ÚLTIMO IRÁ CORRER OS ALGORITMOS QUE PERMITIRÃO FAZER A DISTINÇÃO ENTRE A CHUVA E O GRANIZO, BEM COMO CALCULAR A ENERGIA CINÉTICA, A QUANTIDADE E A DIRECÇÃO DESTE ÚLTIMO.
Patent PT-107625-A (PT)
Title: Recuperador de calor radial usado no interior de condutas
Inventor: CONCEIÇÃO EUSÉBIO ZEFERINO ENCARNAÇÃO DA
IPC: F28D7/00
Filed: 2014-05-08
Abstract: A PRESENTE INVENÇÃO É UTILIZADA NA RECUPERAÇÃO DE CALOR NO INTERIOR DE CONDUTAS. É CONSTITUÍDA POR UM TUBO LONGITUDINAL DE ADMISSÃO (1), UM CONJUNTO DE TUBOS RADIAIS DE ADMISSÃO (2), UM CONJUNTO DE TUBOS DE LIGAÇÃO (3), UM CONJUNTO DE TUBOS RADIAIS DE EXAUSTÃO (4) E UM TUBO LONGITUDINAL DE EXAUSTÃO (5).O FLUIDO NO INTERIOR DA CONDUTA PASSA EM PRIMEIRO LUGAR ATRAVÉS DO CONJUNTO DE TUBOS RADIAIS DE EXAUSTÃO (4), EM SEGUNDO LUGAR ATRAVÉS DO CONJUNTO DE TUBOS LONGITUDINAIS DE LIGAÇÃO (3) E EM TERCEIRO LUGAR ATRAVÉS DO CONJUNTO DE TUBOS RADIAIS DE ADMISSÃO (2). O FLUIDO NO INTERIOR DO RECUPERADOR DE CALOR ENTRA NO TUBO LONGITUDINAL DE ADMISSÃO (1), PASSA NO CONJUNTO DE TUBOS RADIAIS DE ADMISSÃO (2), PASSA PELO CONJUNTO DE TUBOS LONGITUDINAIS DE LIGAÇÃO (3), PASSA PELO CONJUNTO DE TUBOS RADIAIS DE EXAUSTÃO (4) E SAI PELO TUBO LONGITUDINAL DE EXAUSTÃO (5).
Patent PT-117523-A (PT)
Title: Sistema de montagem modular compreendendo peça e respetivo elemento de ligação removível
Inventor: JOSÉ MANUEL DE CASTRO NOVAIS
IPC: B65D21/02
Filed: 2021-10-18
Abstract: A PRESENTE INVENÇÃO REFERE-SE A UMA PEÇA (1) COMPREENDENDO UM ELEMENTO DE LIGAÇÃO FIXO (104) INTEGRADO NA TERCEIRA FACE (106) DA PEÇA (1) PARA ENCAIXE MODULAR, COM PELO MENOS UM ELEMENTO DE LIGAÇÃO REMOVÍVEL (2) E AO RESPETIVO SISTEMA DE MONTAGEM MODULAR. A PEÇA (1) COMPREENDE UMA PRIMEIRA FACE (105) RETANGULAR OPOSTA A UMA SEGUNDA FACE, EM QUE A DITA PRIMEIRA FACE (105) APRESENTA UMA PRIMEIRA CAVIDADE (100) EMBUTIDA NUMA PRIMEIRA EXTREMIDADE DA PEÇA (1), E UMA SEGUNDA CAVIDADE (101) EMBUTIDA NUMA SEGUNDA EXTREMIDADE DA PEÇA (1) E OPOSTA À REFERIDA PRIMEIRA EXTREMIDADE DA PRIMEIRA FACE (105). A PEÇA (1) APRESENTA QUATRO FACES LATERAIS, EM QUE NA QUARTA FACE (107) ESTÃO EMBUTIDAS UMA PRIMEIRA CAVIDADE (102) E UMA SEGUNDA CAVIDADE (103), ADEQUADAS PARA RECEBER POR ENCAIXE UM ELEMENTO DE LIGAÇÃO REMOVÍVEL (2) ATRAVÉS DO ALINHAMENTO COMPLETO DO ENTALHE DA SUPERFÍCIE CÔNCAVA (204).
Patent RU-94007030-A (RU)
Inventor: VALUEV N N
IPC: H01J35/14
Filed: 1994-02-28
Abstract: FIELD: X-ray instruments. SUBSTANCE: incandescence cathode is located in focusing electrode which is insulated from cathode and which cross section is shaped as step- wise groove in which root cathode is at least partially buried. Width H of external part of step-wise groove is greater than its depth G. Preferable H/G ratio is in range of 1.5-2.5. This activates mechanism which limits area of cathode emitting surface by three- dimensional charge. Cathode emitting surface emits thermal- emission electrons from cathode unit in direction of anode under voltage applied between cathode and anode. Said emission depends on bias voltage which is applied to focusing electrode. EFFECT: optimal use of load capacity of tube. 2 cl, 2 dwg
Patent RU-94015130-A (RU)
Inventor: DOROFEEV JU G
IPC: B22F3/26
Filed: 1994-04-25
Abstract: FIELD: metallurgy. SUBSTANCE: method involves molding bilayer blank with easily melting surface layer, subsequent sintering of it combined with impregnation of material of basic layer by easily melting material of surface layer, performing molding of bilayer blank by gas thermal deposition onto cylindrical surface of substrate pressed at pressure 500-700 MPa of coating whose mass consisting 12-18% of substrate mass. EFFECT: enhanced quality of powder blank products.
Patent RU-94027513-A (RU)
Inventor: KRUZHILIN I P
IPC: A01C7/00
Filed: 1994-07-25
Abstract: FIELD: agricultural implements. SUBSTANCE: improved quality of general seeding on restricted plots can be achieved by drill provided with frame, ground wheels, bin with seed feed, seed feed actuators and covering roller. Drill has two rows of furrowers made in the form of spring teeth with concavity, soil mouldboards and with working blades at ends. Teeth of one row are displaced relative to teeth of second row and they are mounted on turnable axle with possible changing of soil penetration depth and transfer to transport position. Bin is provided with device for distributing seeds over drill width and it is located between rows of furrowers and takes the form of slotted spout installed for possible oscillation motion. Covering roller is provided with cleats and primary actuation member for driving seed feeds. EFFECT: high efficiency. 9 cl, 16 dwg
Patent RU-94038138-A (RU)
Inventor: LUR E M S
IPC: G01F1/00
Filed: 1994-10-06
Abstract: FIELD: measurement technology. SUBSTANCE: vortex flowmeter has flow body placed into pipe-line which upper part carries rod and plate electrodes and locating arm installed in cantilever and electrically insulated from flow body. Electric part includes variable voltage generator, amplifier, detector, filter and pulse former. Triple conversion of mechanical vibrations of plate electrode "high frequency voltage - high-frequency current - low-frequency voltage" and big length of interelectrode gap being cause of its small resistance diminish sensitivity of flowmeter. For increase of resistance of interelectrode gap plate electrode is attached to lower part of flow body and is electrically connected to it. Detector has nonlinear transmission characteristic to enhanced sensitivity of flowmeter while working with liquids of different electric conductivity. Univibrator and frequency-to-current converter are added into flowmeter to rise its operational reliability for low-sensitivity signals. EFFECT: enhanced sensitivity while working with liquids of different electric conductivity. 1 cl, 5 dwg
Patent RU-94046299-A (RU)
Inventor: PITER STJUART ALLAN
IPC: B29C48/86
Filed: 1993-05-28
Abstract: FIELD: methods and devices for continuous extrusion of articles. SUBSTANCE: method and device are designed for continuous extrusion of article and performance of its bending by means of force applied to point where its surface becomes solid. The force has transverse component relative to the axis of mold and acts on extruded material additionally to the action in the course of extrusion. Described in the invention are contactless devices of force application, various contacting devices of plunger type, alterative devices of action in which point of force application to extruded article during bending changes relative to extruded article and relative to mold, relative only to extruded article, and relative only to mold; devices for changing direction of bending and for reduction of the required bending force by means of building up of varying pressure of melt inside the mold. EFFECT: higher efficiency.
Patent RU-95100296-A (RU)
Inventor: SHKINEV B P
IPC: F16K1/02
Filed: 1995-01-13
Abstract: FIELD: manufacture of fittings; pipe lines of food-processing, pharmaceutical, chemical, gas and other industries, microbiology; preparation of water. SUBSTANCE: valve is used for quickly shutting off the pipe lines. Valve is provided with drive, body with cover and flexible diaphragm connected with drive. Inner chamber of body is provided with spherical transversal connector engageable with valve flange in cross section. Outer surface of diaphragm is provided with transversal band having spherical surface whose radius is identical to radius of connector and ranges from 43 to 46 mm. EFFECT: increased surface of contact of diaphragm with connector of housing, enhanced tightness of shutting off the pipe line, avoidance of stagnant zones; aseptic conditions of production processes.
Patent RU-95101119-A (RU)
Inventor: MOSKAL G E
IPC: F03B13/12
Filed: 1995-01-24
Abstract: FIELD: hydroelectric power engineering; conversion of energy of sea waves and river currents into electric current. SUBSTANCE: power plant has tower with beam that has mounting box and coupling for connecting energy converter shaft with power take-off shaft of driven mechanism made in the form of telescopic shaft mounted in bearings and provided with longitudinal slots and inner central bore to receive power take-off shaft Wave (current) energy converter is flat floating waterwheel with eight longitudinal ribbon-like cuts both on tip and in bottom planes of wheel that form cells at the same time ensuring water tightness of waterwheel; placed in these cells is thick edge of turning blades attached by means of pins and clips to top and bottom surfaces of waterwheel. Turning blades are interchangeable and have filler and drain plugs for ballast. Ballast weight (water) is introduced only attached to top flats of waterwheel when it is in horizontal position which provides for their setting in upward vertical position in absence of counter-current. In case of current flow or waves on water on water, four turning blades are held vertically and take energy of moving current; this energy is transferred via thrust plate to waterwheel which is set in rotary motion; four other turning blades meeting the current by their convex part are placed on water-wheel top surface providing for flow around it. Turning blades of bottom surface of floating waterwheel are not filled with water and they occupy downward vertical position by gravity. When currents appear, blades on top surface of waterwheel start operating in same manner as top ones and impart rotary motion to water-wheel and, hence, to electric current generator. EFFECT: enlarged functional capabilities.
Patent RU-95101244-A (RU)
Inventor: MUKHIN I G
IPC: F16H15/30
Filed: 1995-01-31
Abstract: FIELD: mechanical engineering; infinitely variable transmission of speed of driven member. SUBSTANCE: transmission has housing with two variable-speed drives mounted in its coaxially; each variable-speed drive is made in the form of curvilinear friction envelopes whose concavities are directed towards each other and gear ratio control mechanism. Housing is cylindrical in form; gear ratio control mechanism is made in the form of double-arm levers mounted in each variable-speed drive and articulated with intermediate friction member by means of axle; these double-arm levers are kinematically linked with arms of double-arm levers of bushes articulated with bow-shaped sectional rods embracing the cylindrical housing; friction envelopes of adjacent variable-speed drives directed towards each other are rigidly interconnected. EFFECT: improved operational characteristics and reduced overall dimensions. 2 cl, 9 dwg
Patent RU-95102135-A (RU)
Inventor: POLISHCHUK A I
IPC: B28B19/00
Filed: 1995-02-14
Abstract: FIELD: civil engineering. SUBSTANCE: method refers to creation of vertical waterproofing of foundations and walls and can be utilized in erection of new and reconstruction of existing buildings and structures. Essence is as follows: plaster slurry is given an additive of ortho-phosphoric acid in amount of 0.02-0.03% of cement mass, and after hardening of plaster course its surface is fused by low-temperature plasma. EFFECT: high efficiency.
Patent RU-95102211-A (RU)
Inventor: KOVALENKO N V
IPC: B28B5/00
Filed: 1995-02-15
Abstract: FIELD: production of expanded clay/concrete wall blocks. SUBSTANCE: line compresses plurality of moulds, accumulator-distributor of foamed concrete mix, mixer with device for metering-out liquid, roller conveyer, and heat treatment chamber. Within heat treatment area for subjecting blocks to heat treatment, roller conveyer is made in form of two, three, four and more parallel running branches provided, each of them, with heat treatment chambers. End portions of heat treatment chambers are provided with telphers and pushers. A stacker is installed upstream of a first heat treatment chamber. Cassette-like moulds are stripped in an area provided with block lifting mechanism and having extension in form of roller conveyer for returning cassette moulds to their initial place. Discharge end of mould returning roller conveyer is mated to entry of roller conveyer of a first vibrating table combined with expanded clay bin, while discharge end of roller conveyer of first vibrating table is coupled via turning table to a second vibrating table combined with accumulator-distributor of foamed concrete mix. Sides of cassette moulds are pressed by clamps to rule out warping of blocks being moulded, thus enabling blocks with high-precision geometric dimensions to be produced. Stacker is provided with deflectable П-shaped frame articulately secured to a carriage to rule out damage to axial ends of cassettes during stacking. Besides, mixer for preparing foamed concrete mix is connected to vessels containing water and a surfactant solution via batchers permitting to effect high-accuracy and high-speed metering of water and surfactant solution. EFFECT: higher process output; wall blacks with greater degree of in-plant readiness for subsequent use are manufactured; higher productivity and higher degree of automation. 4 cl, 9 dwg
Patent RU-95111367-A (RU)
Inventor: RADIN S A
IPC: G01N27/30
Filed: 1995-07-03
Abstract: FIELD: measurement technology. SUBSTANCE: proposed sensor presents dielectric substrate with mutually penetrating comb electrodes on which sensitive coat is deposited. Coat is film made of mixture of two conductive polymers - polysilananiline and polyaniline with proportion 9:1. Structure of sensor can be fitted with third electrode enabling oxidized-reduced state of conductive polymer to be kept with the use of direct current. EFFECT: improved functional stability and reliability.