baber/WOPTO huggingface dataset:
Patent DE-69005885-T2 (DE)
Inventor: CIVIN CURT I
IPC: A61K35/28
Filed: 1990-04-24
Granted: 1994-04-28
Abstract: The present invention comprises a process for release from the cell-receptor complex of positively selected cells in viable, functional condition, where a ligand involved in the particular receptor-ligand interaction utilized for the affinity purification is selectively attacked by one or more degradative enzymes specific for that ligand. A resulting cell suspension can be obtained substantially free of receptor material. This invention, in one embodiment, contemplates a method for positive stem cell selection, utilizing anti-MY 10 and immunomagnetic microspheres to isolate CD34-positive marrow cells and employing an enzyme to release microspheres from the isolated CD34-positive cells. Reproducible enzymatic cleaving of immunomagnetic microspheres from MY10-positive cells can be achieved by brief treatment of the preparation with papain or chymopapain. The isolated CD34-positive cells are particularly desirable for bone marrow transplantation.
Patent DE-69010887-T2 (DE)
Inventor: SIMON JOSEPH A
IPC: B21K1/76
Filed: 1990-12-14
Granted: 1994-11-10
Abstract: An elongated, rod-like rack (10) for use in an automotive-type steering gear assembly and like mechanisms, is formed of an elongated extruded tube divided lengthwise into a substantially solid rack portion (11) and a substantially hollow, link portion (14). Transversely extending teeth (12) are broached on the rack portion (11) for engagement with a drive pinion means and the like for transmitting power through the rack. The rack is formed by positioning a tubular blank within an open ended extrusion die having an extrusion throat and partially pushing the tubular blank through the throat for extruding the material longitudinally and collapsing radially inwardly to form a substantially solid, elongated rack portion. Then, the extrusion is continued with a punch having a mandrel arranged within the blank and within the die throat for extruding a thin wall length (17), forming the hollow, integral link part (14) of the rack (10). The trailing end may be terminated in an inwardly extending, thick wall portion (18) suitable for forming threads thereon. The elongated rack part (11) has a fine, axially extending opening (15) along its length resulting from a space left when the material is inwardly collapsed in the die throat for providing a communication passageway. <IMAGE>
Patent DE-69015750-T2 (DE)
Inventor: TIMMERMAN AUGUST T
IPC: C09D5/00
Filed: 1990-09-21
Granted: 1995-05-11
Abstract: A microwave-absorbing material includes carborundum powder as the major microwave-absorbing pigment in combination with an elastomer carrier. Preferably the microwave-absorbing pigment further includes titanium dioxide, with a more preferable proportion of ten parts carborundum powder to one part titanium dioxide pigment. Advantageously carbon black may also be present as a minor proportion of the microwave-absorbing pigment.
Patent DE-69016603-T2 (DE)
Inventor: LEDIEU JEAN
IPC: G11B7/26
Filed: 1990-11-16
Granted: 1995-06-14
Abstract: Method of manufacturing an optical reading disc, in particular for producing and fixing the recording of a coded datum in a sensitive resin layer applied to a transparent substrate of inorganic material, such as glass in particular, the resin layer preferably being covered on the outside by a thin protective layer. 
<??>According to the invention, this method is characterised in that it consists in recording, in a manner known per se, the signal corresponding to the coded datum by localised activation of the sensitive layer (3) through the substrate (2), and in then removing the protective layer (4), in etching the substrate through the activated zones of the sensitive layer acting as an etching mask, in lifting off the remainder of this sensitive layer, in coating the etched substrate with a thin reflective metallic layer (9) and lastly in depositing a final outer protective layer (10) on the metallic layer. 
<??>The invention also relates to the optical discs obtained by this method. 
<IMAGE>
Patent DE-69022190-T2 (DE)
Inventor: BREDOW CHARLES WILLIAM
IPC: C08K5/5435
Filed: 1990-11-21
Granted: 1996-03-28
Abstract: The invention concerns a composition which may be used in or as a composition for coating or overlaying Portland cement concrete or metal. The composition includes a synthetic polymer latex, an amine-functional epoxy curing agent and an epoxy-functional or amine-functional silane. The composition may additionally comprise an epoxy resin and a filler having a fine particle size.
Patent DE-69102696-T2 (DE)
Inventor: FYSON JOHN
IPC: G03C7/42
Filed: 1991-03-05
Granted: 1994-10-20
Abstract: The invention resides in treating an image-wise exposed and colour developed photographic element with a bleaching agent and a fixing agent. The fixing agent comprises an aliphatic thiol as accelerator. The accelerator present in the fixing agent both stabilizes the fixing agent so that it can be used commercially and prevents staining resultant upon the degeneration of the thiol in the bleach fix bath. The invention also provides a means for efficient silver removal from the fixing bath thereby obviating a separate silver removal stage.
Patent DE-69104312-T2 (DE)
Inventor: SCHLAEFER FRANCIS WILLIAM
IPC: C07C233/05
Filed: 1991-08-23
Granted: 1995-02-16
Abstract: A method of preparing solid hydroxyalkylamides by reacting carboxylic alkyl esters with alkanolamines at controlled reaction temperatures, removing the alcohol byproduct, controlling the temperature of the reaction mixture to form a slurry, maintaining the slurry and recovering the solid hydroxyalkylamides.
Patent DE-69115116-T2 (DE)
Inventor: WHITTEN JEFFREY P
IPC: A61K31/675
Filed: 1991-05-16
Granted: 1996-06-13
Abstract: The present invention is directed to a class of 3-phosphono-piperidine and pyrrolidine derivatives and their use as NMDA antagonists.
Patent DE-69115812-T2 (DE)
Inventor: POHL ERIC RAYMOND
IPC: C07F7/10
Filed: 1991-09-16
Granted: 1996-05-23
Abstract: Novel tertiary-alkyl carbamate silicon compounds are provided which are useful as coupling agents. The compounds have the formula:    (R<3>)3COC(O)N(R<4>)R-Si(R<1>(3-a))(OR<2>)a   wherein the R groups can represent various hydrocarbon and other groups and a has a value of 1 to 3. Processes are also provided for the preparation of the carbamate compounds and their use as coupling agents.
Patent DE-69119450-T2 (DE)
Inventor: SHANKAR RAVI B
IPC: C07D487/04
Filed: 1991-02-25
Granted: 1996-09-26
Abstract: 5,7-Dihydroxy-N-(aryl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides of formula <CHEM>  wherein  X represents H, F, Cl, Br, alkyl or alkoxy,  Y represents H, F, Cl or Br,  R represents H, alkyl or alkyoxy,  Z represents H, Cl or Br,  are prepared by cyclization of N-(3-(((aryl)amino)sulfonyl)-1H-1,2,4-triazol-5-yl)amines with malonyl halides under acidic conditions. With the addition of a phosphorus oxyhalide, malonic acid can be used in place of the malonyl halides and the 5-7-dihydroxy-1,2,4-triazolo[1,5-a]pyrimidine can be directly converted to the corresponding 5,7-dihalo derivative.
Patent DE-69126487-T2 (DE)
Inventor: MATSUO HISAYUKI
IPC: C12P21/02
Filed: 1991-09-11
Granted: 1997-11-27
Abstract: A cDNA coding for a rat derived CNP (rCNP: C-type natriuretic pepteide), and a rat derived CNP precursor protein and derivatives thereof are disclosed. The rat derived CNP precursor is represented by the following amino acid sequence. <IMAGE>   The rCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.
Patent DE-69128359-T2 (DE)
Inventor: LEWIS THOMAS
IPC: B41C1/04
Filed: 1991-09-30
Granted: 1998-04-30
Abstract: A method of extending the useful life and/or enhancing the performance of wet or dry lithographic printing plates. A strong curable composition that adheres to the ink-receptive plate areas is first applied to an imaged plate. After removal of the composition from non-image plate areas, it is cured, thereby augmenting the resilience of the ink-receptive plate areas. If imaging of the plate results in surface recesses, the cured composition can enhance plate performance by making the entire surface coplanar.
Patent DE-69128944-T2 (DE)
Inventor: BUCKWALTER BRIAN LEE
IPC: C07C237/22
Filed: 1991-04-18
Granted: 1998-06-25
Abstract: The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.
Patent DE-69200505-T2 (DE)
Inventor: LAPLUYE GERARD
IPC: B01J19/00
Filed: 1992-03-04
Granted: 1995-02-23
Abstract: PCT No. PCT/FR92/00197 Sec. 371 Date Sep. 7, 1993 Sec. 102(e) Date Nov. 8, 1993 PCT Filed Mar. 4, 1992 PCT Pub. No. WO92/15867 PCT Pub. Date Sep. 17, 1992.Method and device for the synthesis of macromolecules, including peptides, polynucleotides or oligosaccharides. The method and device involves a reactor which contains a solid support on which a component of the product to be synthesized is fixed. The reactor comprises filters at its ends and is mounted movably for rectilinear reciprocating movement in a vessel which contains a reactive liquid. A temperature probe is provided to detect the temperature variations of the reactive liquid due to passage into and out of the reactor. The progress of coupling and deprotection reactions which occur in the synthesis of peptides, polynucleotides and oligosaccharides is monitored.
Patent DE-69206456-T2 (DE)
Inventor: GHIDONI DARIO DR
IPC: C08L51/06
Filed: 1992-03-27
Granted: 1996-06-20
Abstract: Described are thermoplastic compositions with improved mechanical characteristics, comprising   (A) an impact-resistant vinylaromatic graft copolymer containing from 0.1 to 2% by weight of an ethylenically unsaturated compound having a carboxylic group or one of its derivatives in the molecule;   (B) a polyamide resin and   (C) a polyolefin. m
Patent DE-69306559-T2 (DE)
Inventor: GRISAR J
IPC: C07D311/58
Filed: 1993-03-08
Granted: 1997-04-10
Abstract: This invention relates to certain hydroxy derivatives of 3,4-dihydro-2,5,7,8-tetraalkyl-2H-1-benzopyran-2-carboxylic acids and the lactones thereof, to the processes and intermediates useful for their preparation and to their use as free radical scavengers useful in the treatment of tissue damage implicated with free oxygen radicals.
Patent DE-69309920-T2 (DE)
Inventor: THORNTON ARTHUR ROGER DAVID
IPC: G06K9/00
Filed: 1993-03-29
Granted: 1997-11-20
Abstract: PCT No. PCT/GB93/00639 Sec. 371 Date Feb. 13, 1995 Sec. 102(e) Date Feb. 13, 1995 PCT Filed Mar. 29, 1993 PCT Pub. No. WO93/19670 PCT Pub. Date Oct. 14, 1993An apparatus for testing hearing comprises a sound source for applying a sound to the subject's ear and a sound detector for detecting the sound returned from the subject's inner ear in response to the sound. The sound source, which is driven by stimulus generation equipment connected to an analyzer, produces a sequence of sounds constituting a maximum length sequence to record Evoked Otacoustic Emissions.
Patent DE-69310642-T2 (DE)
Inventor: CLEMENT MICHEL
IPC: G01H1/00
Filed: 1993-08-26
Granted: 1997-10-30
Abstract: The invention relates to a method and a device for optical measurement of vibrations, in particular of rotating turbine blades. With the wheel moving with a determined rotational speed, the method includes the following steps:   - generation of three reference signals from the detection of the passage of a marking (101), made on the hub (2) of the turbine wheel, by an optical detector (100), - detection of measurement signals on passage of another marking (201, 301, 401) made on at least any one of the parts of the blade, in front of another optical detector (200, 300, 400), the blade being in oscillation, - determining of the time shifts existing between each of the reference signals and each of the measurement signals, these shifts being, in the absence of oscillations of the blade, zero or equal to determined constant values, and - instantaneous calculation of the vibrational components of the blade in amplitude, frequency and phase from the various shifts measured.   The markings are made on the side of the blade and optionally on an edge and the top of the blade. <IMAGE>
Patent DE-69312877-T2 (DE)
Inventor: PARRON JEAN-CLAUDE
IPC: C08G18/72
Filed: 1993-11-29
Granted: 1998-03-05
Abstract: The present invention relates to a mixture of polyisocyanates which comprises chemically modified tolylene diisocyanate and 1,6-hexamethylene diisocyanate. It also relates to the use of this mixture of polyisocyanates for the preparation of flexible highly elastic polyurethane foams.
Patent DE-69334035-T2 (DE)
Inventor: LIPTON STUART A
IPC: A61K9/70
Filed: 1993-09-22
Granted: 2006-12-28
Abstract: Disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric-oxide or related redox species, in a concentration effective to effect neuroprotection. Also disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric oxide (or a related redox species such as NO31 or NO+equivalent), or a physiologically concentration effective to cause such neuroprotection.
Patent DE-69413008-T2 (DE)
Inventor: PERRY BRUCE
IPC: A61F13/511
Filed: 1994-02-10
Granted: 1999-02-25
Abstract: An absorbent article such as a sanitary napkin having an improved topsheet that provides improved skin comfort as well as superior fluid handling characteristics. Such absorbent articles comprise a liquid pervious topsheet, a liquid impervious backsheet, and an absorbent core positioned between the topsheet and the backsheet. The topsheet has a central zone and an outer zone extending laterally outwardly from and contiguous with the central zone. The topsheet comprises an outer portion located substantially in the outer zone and a central portion located substantially in the central zone. The outer portion includes a microapertured polymeric web which exhibits a soft and silky tactile impression. The central portion includes a macroscopically-expanded, apertured formed-film for the transmission of bodily fluids deposited on the topsheet.
Patent DE-69413467-T2 (DE)
Inventor: YE GUOJI
IPC: A61K36/537
Filed: 1994-07-14
Granted: 1999-06-10
Abstract: A remitting agent for nephrotic syndrome and hepatopathy symptoms comprises a water-soluble polysaccharides having poly-D-galacturonic acid or a methyl ester thereof as an effective constituent. The polysaccharide can be a pectic substance and preferably is an aqueous extract of Tanjin having the following characteristics:     A. Sugar content: 60 to 100 %     (1) Sugar composition: 40 to 80 % of uronic acid (composed almost entirely of D-galacturonic acid) and  10 to 30 % of neutral sugars   (2) Neutral sugar composition:  0 to 15 % of rhamnose  0 to 15 % of glucose  25 to 55 % of galactose  30 to 60 % of arabinose  0 to 15 % of mannose   B. Molecular weight: 150,000 to 300,000. s
Patent DE-69415884-T2 (DE)
Inventor: LE COMTE ROGER
IPC: G01N1/00
Filed: 1994-07-12
Granted: 1999-08-26
Abstract: A needle (16) which can be moved in order to sample the liquid in the bottle, is mounted on a slide (5) which can be moved vertically with respect to a support plate (1) incorporated in the sampling apparatus. The sampling needle penetrates a percussion head (10) mounted on the base of the plate, to which head a piercing needle is connected. A rinsing duct (12) connects the percussion head with the outside. Application to the sampling of blood in a haematological analysis apparatus. <IMAGE>
Patent DE-69421543-T2 (DE)
Inventor: TIHON CLAUDE
IPC: A61B17/00
Filed: 1994-09-01
Granted: 2000-05-25
Abstract: An apparatus for electrosurgical incision of a stricture within or adjacent to a body lumen, which comprises an electrically conducting, deflectable wire associated with an introducer for introducing the apparatus into the body lumen, wherein a proximal portion of the wire is deflectable outwardly relative to the introducer, and a source of RF electric current connected to the wire whereby RF electric current may be transmitted through the wire when it is in the deflected position.
Patent DE-69430047-T2 (DE)
Inventor: IMAI SHOICHI
IPC: A61K31/472
Filed: 1994-12-20
Granted: 2002-10-17
Abstract: The object of the present invention is to provide novel pharmaceutical compositions containing isoquinoline derivatives which exhibit excellent inhibitory action against isozymes of phosphodiesterase of the type IV (PDEIV). The active components of the pharmaceutical composition according to the present invention are isoquinoline derivatives which are represented by the following general formula or a pharmaceutically-acceptable salt thereof. <CHEM>     [in the formula, R is hydrogen or an alkoxy group] The compounds according to the present invention have excellent inhibitory action which is highly specific to PDEIV. Therefore, they are very useful in pharmaceuticals such as antidepressive agents, tranquilizers, antidemential agents, antiinflammatory agents, antiallergic agents, antiasthmatic agents, liverprotecting agents, diuretic agents, etc.
Patent DE-69433688-T2 (DE)
Inventor: LAUKS IMANTS R
IPC: B01L3/00
Filed: 1994-10-13
Granted: 2005-04-28
Abstract: A device and method for collecting a fluid sample and introducing it into a sensing device for real time analysis providing flexibility and simplicity in the way sample fluid sample collection is accomplished and cooperating with a disposable cartridge of the sensing device to permit quick and easy sample introduction and eliminate the risk of sample spillage, an exemplary embodiment of the collection device includes a capillary tube capable of receiving or drawing a fluid sample and introducing the fluid sample into the disposable cartridge, a reservoir chamber capable of receiving a fluid sample and a capillary tube holder capable of supporting one end of the capillary tube in the reservoir chamber to draw the fluid sample by is capillary action. Alternative embodiments of the invention are used in combination with the variety of blood collection assemblies employed by the medical industry to collect fluid samples.
Patent DE-69509611-T2 (DE)
Inventor: MUELLER ROLF
IPC: B65G17/12
Filed: 1995-10-12
Granted: 2000-01-13
Abstract: There is provided a mechanism 10 for conveying cans 11 along a path 12. The mechanism has a drive chain 14 to which are pivotally attached carriages 17 having conveyors 18 with recessed pockets 19. Each carriage also has a fixed cog 20 which meshes with a second sprocket 21 which is rotated at a different speed to the main sprockets 15 of the drive chain 14. Selection of the relative speeds and teeth ensure that the conveyors 18 remain parallel to each other throughout their path. <IMAGE>
Patent DE-69509888-T2 (DE)
Inventor: ALOUP JEAN-CLAUDE
IPC: A61P29/00
Filed: 1995-03-23
Granted: 1999-09-30
Abstract: PCT No. PCT/FR95/00357 Sec. 371 Date Sep. 27, 1996 Sec. 102(e) Date Sep. 27, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26349 PCT Pub. Date Oct. 5, 1995The compounds of formula (I)    <IMAGE>  (I)  wherein R, R1 and R2 are defined in the disclosure, and salts thereof. The compounds of formula (I) are non-competitive N-methyl-D-asparate (NMDA) receptor antagonists, particularly NMDA receptor glycine modulation site ligands, and are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, this receptor is also known as the quisqualate receptor.
Patent DE-69518933-T2 (DE)
Inventor: SEVERINSSON LARS
IPC: F16D65/16
Filed: 1995-10-24
Granted: 2001-01-18
Abstract: A disc brake caliper comprises a housing (1) to be arranged astraddle of a vehicle brake disc, a cover (2) attached to the housing (1), two thrust sleeves (8), which are connected to a brake pad (5) and which are axially movable in the housing (1), a cross bar (9) connecting the two thrust sleeves (8), and a lever (17) for transmitting a brake force from a brake cylinder (4), attached to the caliper, to the cross bar (9). The brake application mechanism for this caliper includes the thrust sleeves (8), the cross bar (9), and the lever (17) and is self-sustained and can be delivered and mounted as a unit in the housing (1). <IMAGE>
Patent DE-69531749-T2 (DE)
Inventor: HERRMANN DIETER
IPC: A61K31/7064
Filed: 1995-05-23
Granted: 2004-07-29
Abstract: The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) <CHEM>     wherein   R<1>   may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R<2>   may be hydrogen, a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, X   represents sulfur, a sulfinyl or sulfonyl group;and   Nucl. represents     2',3'-Didesoxy-2',3'-difluorothymidine     2'-Desoxy-2'-aminoadenosine     2'-Desoxy-2'-azidoadenosine     2'-Desoxy-2'-azidocytidine     2'-Desoxy-5-fluorouridine     2-Fluoro-2'-desoxyadenosine their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds.
Patent DE-69532031-T2 (DE)
Inventor: KHAN KARRAR AHMAD
IPC: A61K31/195
Filed: 1995-01-30
Granted: 2004-07-22
Abstract: PCT No. PCT/EP95/00321 Sec. 371 Date Jul. 31, 1996 Sec. 102(e) Date Jul. 31, 1996 PCT Filed Jan. 30, 1995 PCT Pub. No. WO95/20953 PCT Pub. Date Aug. 10, 1995There is disclosed a solid fast dispersing dosage form of a pharmaceutical composition suitable for oral administration comprising: a therapeutic agent which comprises one or more compound thyroid hormone or hormones; from about 80% to about 99.9% of disintegrating agent by mass; from about 0.01% to about 10% of flavoring agent by mass; and from about 0.1% to about 5% mass of lubricating agent by mass; which has utility in the treatment of disorders associated with the improvement of the thyroid hormone function in animals including human beings.
Patent DE-69534250-T2 (DE)
Inventor: LIU MARGARET A
IPC: C12N15/09
Filed: 1995-11-13
Granted: 2006-05-04
Abstract: Genes encoding Mycobacterium tuberculosis (M.tb) proteins were cloned into eukaryotic expression vectors to express the encoded proteins in mammalian muscle cells in vivo. Animals were immunized by injection of these DNA constructs, termed polynucleotide vaccines or PNV, into their muscles. Immune antisera was produced against M.tb antigens. Specific T-cell responses were detected in spleen cells of vaccinated mice and the profile of cytokine secretion in response to antigen 85 was indicative of a Th1 type of helper T-cell response (i.e., high IL-2 and IFN-gamma). Protective efficacy of an M.tb DNA vaccine was demonstrated in mice after challenge with M.bovis BCG, as measured by a reduction in mycobacterial multiplication in the spleens and lungs of M.tb DNA-vaccinated mice compared to control DNA-vaccinated mice or primary infection in naive mice.