Patent SG-11201908602U-A (SG)
Title: Combination therapy for the treatment of solid and hematological cancers
Inventor: MANNING PAMELA
IPC: A61K39/395
Filed: 2018-03-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIPO I PCT °mono n o olommoolimoilowo VII IE (10) International Publication Number WO 2018/175790 Al (51) International Patent Classification: A61K 39/00 (2006.01) A61K 41/00 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/US2018/023860 (22) International Filing Date: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: (26) Publication Language: (30) Priority Data: 22 March 2018 (22.03.2018) English English 62/475,036 22 March 2017 (22.03.2017) US 62/475,032 22 March 2017 (22.03.2017) US 15/871,802 15 January 2018 (15.01.2018) US (71) Applicant: ARCH ONCOLOGY, INC. [US/US]; 4320 Forest Park Ave., Suite 303, St. Louis, MO 63108 (US). (72) Inventors: MANNING, Pamela, T.; 4320 Forest Park Ave., Suite 303, St. Louis, MO 63108 (US). PURO, Robyn; 4320 Forest Park Ave., Suite 303, St. Louis, MO 63108 (US). ALMAGRO, Juan, C.; 4320 Forest Park Ave., Suite 303, St. Louis, MO 63108 (US). KARR, Robert, W.; 4320 Forest Park Ave., Suite 303, St. Louis, MO 63108 (US). CAPOCCIA, Benjamin, J.; 4320 Forest Park Ave., Suite 303, St. Louis, MO 63108 (US). (74) Agent: MCNEILL, Rebecca, M.; McNeill Baur PLLC, 125 Cambridge Park Drive, Suite 301, Cambridge, MA 02140 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 1-1 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, O MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, N kr) N 1-1 (54) Title: COMBINATION THERAPY FOR THE TREATMENT OF SOLID AND HEMATOLOGICAL CANCERS GO (57) : Methods are provided for using anti-CD47 mAbs as therapeutics for the prevention and treatment of solid and hemato- 0 logical cancers, with other anti-cancer agents, more specifically, chemotherapeutic agents, which include but are not limited to anthra- \" cyclines, platinums, taxols, topisomerase inhibitors, anti-metabolites, anti-tumor antibiotics, mitotic inhibitors, and alkylating agents. C