baber/WOPTO huggingface dataset:
Patent NZ-576489-A (NZ)
Title: Prophylactic tuberculosis vaccine
Inventor: CARDONA IGLESIAS PERE JOAN
IPC: A61K39/00
Filed: 2007-10-17
Abstract: Provided is the use of an immunotherapeutic agent comprising cell wall fragments of a virulent strain of Mycobacterium tuberculosis-complex (MTB-C) for the preparation of a drug for the prophylactic treatment of tuberculosis, wherein said agent is obtained by a method comprising the following steps: - cultivate the virulent MTB-C strain over a period equal to or greater than three weeks and, subsequently, - homogenate the cell culture in the presence of a nonionic surfactant, - separating the non-fragmented cells and the solubilized components by means of centrifugation, - subjecting the fraction of cell wall fragments to chemical or physical treatment to inactivate the eventual virulent strain cells that it eventually contains, and - optionally drying the obtained immunotherapeutic agent by means of lyophilisation.
Patent NZ-577916-A (NZ)
Title: Cyclopamine analogs
Inventor: AUSTAD BRIAN
IPC: A01N43/42
Filed: 2007-12-27
Abstract: Disclosed herein are cyclopamine compounds of the given formula, wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful for their activity in the inhibition of the hedgehog pathway and as such are useful in the treatment of cancer.
Patent NZ-580425-A (NZ)
Title: Combination enzyme therapy for digestion of dietary gluten
Inventor: GASS JONATHAN DAVID
IPC: A61K38/48
Filed: 2008-03-14
Abstract: Disclosed is an enzyme composition for the detoxification of gluten, comprising an effective dose of cysteine endoprotease B, isoform 2 (EP-B2) and Sphingomonas capsulata prolyl endopeptidase (SC-PEP) in a ratio that provides for synergistic activity in detoxifying gluten toxicity, wherein the ratio of EP-B2:SC-PEP is from about 10:1 to about 1:10 by specific activity. Also disclosed is an in vitro method of detoxifying gluten, the method comprising contacting gluten containing foodstuff with an effective dose of a glutamine endoprotease B, isoform 2 (EP-B2) and a Sphingomonas capsulata prolyl endopeptidase (SC-PEP) in a ratio that provides for synergistic activity in detoxifying gluten toxicity, wherein the ratio of EP-B2: SC-PEP is from about 10:1 to about 1:10 by specific activity.
Patent NZ-583684-A (NZ)
Title: Substituted nicotinamide compounds and the use thereof in pharmaceutical products
Inventor: KUHNERT SVEN
IPC: A61K31/33
Filed: 2008-09-15
Abstract: Disclosed is a substituted nicotinamide compound of formula (I) which is substituted by a thioethyl group which has a terminal sulfonyl group. Also disclosed is a medicament comprising a compound of formula (I). Further disclosed is the use of a compound of formula (I) or a medicament comprising a compound of formula (I) in the preparation of a medicament for the treatment of pain, epilepsy, migraine, anxiety states and urinary incontinence.
Patent NZ-584691-A (NZ)
Title: Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators
Inventor: CZECHTIZKY WERNGARD
IPC: A61K31/4025
Filed: 2008-10-14
Abstract: Disclosed are substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides, represented by formula (I), or salts, enantiomers or diastereomers thereof. Also disclosed is the use of the compounds of formula (I) for treating a disease selected from sleep related disorder, dementia, Alzheimer's disease, multiple sclerosis, cognitive disorder, attention deficit hyperactivity disorder and depression.
Patent NZ-590763-A (NZ)
Title: Centrifuge separator with a rotating bowl for use in the separation of wax and honey
Inventor: WARD ROSS ALLAN
IPC: A01K59/04
Filed: 2011-01-28
Abstract: 590763 A centrifuge separator including a mounting portion that releasably retains a centrifuge bowl in either stationary or spinning motion about two mounting points. A centrifuge bowl is spindled between the mounting points with the longitudinal spin axis of the bowl being in a substantially horizontal plane. One distil end of the bowl is inclined 0-30 degrees higher than an opposing distil end of the bowl, such that an inlet end of the bowl is vertically higher than an outlet end of the bowl. The bowl has an inlet through which raw material passes and an outlet through which a separated liquid product and/or separated solid product passes. An adjustable spring tensioner urges the centrifuge bowl towards one or both mounting points thereby maintaining a constant load against one or both mounting points.
Patent NZ-591690-A (NZ)
Title: TUMOR-ASSOCIATED PEPTIDES BINDING PROMISCUOUSLY TO HUMAN LEUKOCYTE ANTIGEN (HLA) - Seq ID No 25 CLASS II MOLECULES
Inventor: DENGJEL JOERN
IPC: A61K39/00
Filed: 2006-09-05
Abstract: Disclosed are immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumour-associated T-helper cell peptide epitopes, alone or in combination with other tumour-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumour immune responses. In particular, the present invention relates to a novel peptide sequence, SEQ ID NO:25, derived from HLA class II molecules of human tumour cell lines which can be used in vaccine compositions for eliciting anti-tumour immune responses. (62) Divided Out of 566104
Patent NZ-596826-A (NZ)
Title: Polycyclic antagonists of lysophosphatidic acid receptors
Inventor: SEIDERS THOMAS JON
IPC: A61K31/42
Filed: 2010-06-03
Abstract: 596826 Disclosed herein are compounds of Formula (I), wherein the variables are defined in the specification, and the use thereof in the treatment of cancer or fibrosis. In certain embodiments the compound is 1-{ 4’-[3-methyl-4((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl} -cyclopropanecarboxylic acid, or (3-methyl-5-{ 4’-[1-(1H-tetrazol-yl)-cyclopropyl]-bipheny1-yl} -isoxazol-4-yl)-carbamic acid (R)-1-phenyl-ethyl ester.
Patent NZ-596863-A (NZ)
Title: Alkanoylamino benzamide aniline hdac inhibitor compounds
Inventor: GRAUPE MICHAEL
IPC: A61K31/4965
Filed: 2010-06-07
Abstract: 596863 The present disclosure provides an N-(2-aminophenyl)-4-alkylamido-benzamide compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
Patent NZ-612929-A (NZ)
Title: Anti-cocaine compositions and treatment
Inventor: LANDRY DONALD
IPC: C12N9/16
Filed: 2007-07-10
Abstract: An isolated mutant cocaine esterase (CocE) polypeptide comprising an amino acid sequence at least 85% identical to SEQ ID NO: 1, wherein SEQ ID NO: 1 has at least one substitution, addition or deletion selected from the group consisting of L163V, V225I, I218L, A310D, A149S, S159A, S265A, S56G, W220A, S140A, F189L, A193D, T254R, N42V, V262L, L508G, Y152H, V160A, T172R, Y532F, T74S, W285T, L146P, D533S, A194R, G173Q, C477T, K531A, R41I, L119A, K46A, 10 F84Y, T172R-G173Q, L169K, F189A, N197K, R182K, F189K, V190K, Q191K, A194, I175-G-G-A186, and T176-G-G-D18; and the mutant CocE polypeptide has esterase activity with increased thermostability at 37°C as compared to wild-type CocE, wherein SEQ ID NO: 1 is disclosed within the specification.
Patent NZ-616538-A (NZ)
Title: Holding strap component
Inventor: REINDERS SHAUN RICHARD
IPC: B62J7/08
Filed: 2013-10-10
Abstract: Disclosed is a holding strap component (10). The holding strap component (10) includes an elastic section (12). The elastic section (12) includes a sleeve or tube (14) formed from a flexible material and at least one elastic member (16) which is secured at either end to respective parts (18, 20) of the sleeve or tube (14). The flexible material expands when the elastic member (16) is stretched and contracts when the elastic member (16) is un-stretched. A first extent (26) and second extent (28) depend from respective ends (22, 24) of the elastic section (12). During expansion, the respective parts (18, 20) of the sleeve or tube (14) are separated by a length longer than the elastic member (16) when the elastic member (16) is un-stretched. The elastic member (16) is unable to be stretched beyond the expanded length of the respective parts (18, 20) of the sleeve or tube (14). This arrangement allows tension to remain on the holding strap should a secured load shift and require a shorter length holding strap.
Patent NZ-619699-A (NZ)
Title: Processes and intermediates for producing azaindoles
Inventor: TANOURY GERALD J
IPC: C07F5/04
Filed: 2012-07-03
Abstract: Disclosed herein is a process for preparing an azaindole compound of Formula I, wherein the substituents are as defined in the specification. The process comprises reacting intermediates in water, organic solvents, a base, and a transition metal catalyst, wherein the organic solvents are selected from the group consisting of acetonitrile, toluene, N,N-dimethylformamide, N,N-dimethylacetamide, acetone, methyl tert-butyl ether, methanol, propanol, isopropanol, butanol, and tert-butanol. In a particular embodiment, the process produces compounds of Formula Ia [(R)-2-(2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide] and Ib [2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)-2-methy-N-(2,2,2-trifluoroethy)propanamideand (Ib)]. The compounds of Formula I are useful as inhibitors of Janus kinases (JAK).
Patent NZ-622859-A (NZ)
Title: File encryption method and device, file decryption method and device
Inventor: BI TINGLI
IPC: G06F21/60
Filed: 2012-06-14
Abstract: Disclosed are a file encryption method and device and a file decryption method and device. The file encryption method comprises creating a virtual disk. The virtual disk receiving a write request from a file system, encrypting data carried in the write request, and notifying the file system of writing the encrypted data into a corresponding physical disk, so that the file system writes the encrypted data into the corresponding physical disk after receiving the notification from the virtual disk. The file encryption method and device, the file decryption method and device of the present invention adopt a virtual disk to encrypt the data in the write request, and adopt a virtual disk to decrypt data requested by a read request, so as to implement reliable, safe, and effective file encryption.
Patent NZ-630169-A (NZ)
Title: Anhydrous transdermal formulations
Inventor: BATT LAURIE ROBERT
IPC: A61P33/10
Filed: 2014-02-27
Abstract: The present invention relates to a method of treating a non-human mammal with a non-aqueous composition that comprises a permeation enhancer such as a mono-terpene, for delivering an active ingredient transdermally. The composition comprises at least on one active ingredient, a mono-terpineterpene, and non-heterocyclic ester solvent and/or a tripropylene glycol alkyl ether. The composition can be used to deliver a range of actives, such as anthelmintics, including levamisole, abamectin or moxidectin. The present invention provides a platform composition and can be used to deliver a wide variety of active ingredients and combinations thereof transdermally to mammals.
Patent NZ-700499-A (NZ)
Title: Traffic surveillance system
Inventor: CRONA BJÖRN
IPC: G08G1/04
Filed: 2014-09-30
Abstract: Traffic surveillance system (1), wherein the system (1) is adapted to track and register vehicles passing a surveillance zone (2). The traffic surveillance system (1) comprises a carrying structure (3) and a plurality of traffic surveillance devices, wherein the traffic surveillance devices are adapted to be mounted upon the carrying structure (3) and comprises at least a vehicle identity registration device (4) and a vehicle tracking device (5). The surveillance zone being defined as the coverage of the devices and provided in a plane (22) from which the carrying structure (3) protrudes, wherein the surveillance zone (2) comprises a plurality of gateway zones (6) and at least one interconnecting zone (7), which interconnecting zone (7) connects at least two gateway zones (6) with each other. The vehicle identity registration device (4) is arranged such upon the carrying structure (3) that it define the gateway zones (6) in that it is adapted to record a passage of a vehicle into or out from the surveillance zone (2) through the gateway zones (6) and the vehicle tracking device (5) is arranged such upon the carrying structure (3) that it defines essentially arc shaped interconnecting zone (7).
Patent NZ-701794-A (NZ)
Title: Density phase separation device
Inventor: BARTFELD BENJAMIN
IPC: G01N1/10
Filed: 2010-05-14
Abstract: A mechanical separator (40) for separating a fluid sample into first and second phases within a collection container (82) is disclosed. The mechanical separator (40) has a separator body with a through-hole (46) adapted for allowing fluid to pass through. The separator body includes a float (42), having a first density, and a ballast (44), having a second density greater than the first density. The body also includes a seal between the separator (40) and the container (82). In use the separator changes position in a centrifuge from a position in which fluid can flow (F) through the hole to a closed position.
Patent NZ-709648-A (NZ)
Title: Crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl)benzamide and its mono hydrochloride salt
Inventor: MURRAY CHRISTOPHER
IPC: A61K31/5025
Filed: 2013-12-12
Abstract: Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{ 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl} benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein. The instant application is directed to a novel crystalline Form A of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{ 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl} benzamide mono hydrochloride that maintains its form under particular thermal, humidity, and pressure stresses.
Patent NZ-716357-A (NZ)
Title: Antibody specifically binding to glp-1r and fusion protein thereof with glp-1
Inventor: ZHANG CHENG
IPC: C07K16/28
Filed: 2014-08-01
Abstract: Disclosed in the present invention is an antibody specifically binding to GLP-1R and a fusion protein thereof with GLP-1. The fusion proteins can effectively bind to a human GLP-1R receptor and activate a receptor signalling channel, thus are useful for treating diabetes, excessive weight, obesity and related disorders thereof.
Patent NZ-723308-A (NZ)
Title: A fluid distribution system for selectively distributing fluid from multiple locations and conduit arrangement for distributing fluid from multiple locations
Inventor: MESSNER KENNETH WAYNE
IPC: B05B12/00
Filed: 2015-01-20
Abstract: Fluid distribution system comprising conduit (1) with openings (2), membrane (3) for covering of openings, deflector (211) for manipulating membrane (3, 7), activator (210) which is movable in the conduit with propulsion and control, the activator for communicating via deflector to manipulate membrane and uncover openings for fluid to be emitted from the conduit in relative vicinity. Such a system is stated to be an improvement on prior art systems particularly used for drip irrigation lines.
Patent NZ-739115-A (NZ)
Title: Ball and cup impactors for implanting a hip prosthesis
Inventor: TERMANINI ZAFER
IPC: A61B17/00
Filed: 2016-07-15
Abstract: In the course of hip replacement surgery with a reverse hip prosthesis an acetabular cup is implanted in an acetabular socket in the pelvic bone. There is a need for instruments, kits and methods of assembling the instrument with acetabular cup which facilitate positioning of the acetabular cup. New surgical instrument and methods used to implant the acetabular cup element of a reverse hip prosthesis in a patient are described. The surgical instrument, which is for use with an acetabular cup having a stem extending from the bottom of a concave inner surface of the acetabular cup, has a collet at the distal end of a handle for gripping the stem of the acetabular cup and inclination and anteversion rods affixed to a rotatable guide collar mounted on the handle which are used to position the acetabular cup. This allows for a more controlled placement of the acetabular cup.
Patent NZ-749028-A (NZ)
Title: Chimeric antigen receptors
Inventor: ABBOT STEWART
IPC: C07K14/705
Filed: 2013-12-19
Abstract: Provided herein are therapeutic polypeptides, e.g., chimeric antigen receptors, able to direct an immune cell, e.g., a T lymphocyte to a target antigen, and able to cause the T cell to proliferate or to kill cells displaying the antigen when the antigen binds to the polypeptide, wherein the polypeptides comprise a transmembrane domain from a T cell co-inhibitory protein such as CTLA4 or PD-1. Also provided herein are T lymphocytes expressing the polypeptides, and use of such T lymphocytes to treat diseases such as cancer.
Patent NZ-751165-A (NZ)
Title: Mooring system for drifting energy converters
Inventor: Sheldon-Coulson Garth Alexander
IPC: F03B13/18
Filed: 2017-08-02
Abstract: A formation-restoring system for drifting Motion-To-Electrical Energy Transforming Devices (MTEETDs) wherein relative and/or absolute geographical positions of two or more MTEETDs are maintained by separation restorative tethers that maintain a desired formation/distance through use of a tether tensioning mechanism, each tether comprises multiple positively buoyant elements connected to a single negatively buoyant element, the positively buoyant elements being biased towards a critical distance as the single negatively buoyant element provides a restorative correcting force when the positively buoyant elements are moved apart by water and/or wind currents, the use of the separation restorative tethers allows for reduced requirements for the amount of anchored devices within a system for maintaining formation of MTEETDs.
Patent PT-105296-A (PT)
Title: Ligador de condutores eléctricos
Inventor: OLIVEIRA PAULO CARLOS
IPC: H01R4/48
Filed: 2010-09-17
Abstract: DIVULGA-SE UM LIGADOR QUE PERMITE A INSTALAÇÃO E REMOÇÃO DE CONDUTORES (3) ELÉCTRICOS, EM PARTICULAR CONDUTORES (3) FLEXÍVEIS, DE MODO VERSÁTIL E SEGURO, GARANTINDO UMA INSTALAÇÃO SEGURA E UMA MANUTENÇÃO RÁPIDA. O LIGADOR DA PRESENTE INVENÇÃO É ESSENCIALMENTE FORMADO POR UM CORPO (1) PRINCIPAL DE ALOJAMENTO QUE COMPREENDE UM CORPO (4) INTERNO DE MATERIAL CONDUTOR DE ENERGIA ELÉCTRICA, UM DISPOSITIVO (5) DE PREENSÃO DE FIOSCONDUTORES, UM DISPOSITIVO (6) DE ACCIONAMENTO DO REFERIDO DISPOSITIVO (5) DE PREENSÃO E ABERTURAS (7) PARA INSERÇÃO DE FIOS (3) DE CONDUÇÃO ELÉCTRICA. ESPECIFICAMENTE, O PRESENTE LIGADOR ESTÁ DOTADO DE UM DISPOSITIVO (6) DE CCIONAMENTO INDEPENDENTE PARA CADA DISPOSITIVO (5) DE PREENSÃO, O QUE PROPORCIONA INSTALAÇÕES MAIS FIÁVEIS DO QUE AS PROPORCIONADAS POR LIGADORES DO ESTADO DA TÉCNICA POSSUINDO UM ACCIONAMENTO (6)COMUM A TODOS OS DISPOSITIVOS (5) DE PREENSÃO DE CONDUTORES (3) ELÉCTRICOS.
Patent PT-105367-A (PT)
Title: Método de melhoria do agendamento de reservas de recursos em redes com comutação óptica de agregados de pacotes
Inventor: RODRIGUES JOEL J P C
IPC: H04B10/25
Filed: 2010-11-05
Abstract: O PRESENTE INVENTO DIZ RESPEITO A UM NOVO PROTOCOLO DE RESERVA DE RECURSOS PARA REDES COM COMUTAÇÃO ÓPTICA DE AGREGADOS DE PACOTES (REDES OBS - OPTICAL BURST SWITCHING), CHAMADO ENHANCED JUST-IN-TIME-PLUS (E-JIT+). ESTE PROTOCOLO INTRODUZ UMA MELHORIA A NÍVEL DE AGENDAMENTO DE RESERVAS DE RECURSOS EM REDES OBS, PERMITINDO UM NÚMERO DE AGENDAMENTOS DE RESERVAS ILIMITADO, OPTIMIZANDO A UTILIZAÇÃO DO CANAL DE DADOS E REDUZINDO A PROBABILIDADE DE PERDA DE BURSTS. ESTA INOVAÇÃO É, PREFERENCIALMENTE, UTILIZADA PARA OPTIMIZAR O DESEMPENHO DOS PROTOCOLOS DE RESERVA DE RECURSOS E, CONSEQUENTEMENTE, MELHORAR O DESEMPENHO DAS REDES COM COMUTAÇÃO ÓPTICA DE AGREGADOS DE PACOTES.
Patent RO-90144-A (RO)
Inventor: WRULICH HERMIG
IPC: E21C35/23
Filed: 1984-04-09
Abstract: For cutting rock by means of cutting head (1) having its bits (24) cooperating over a limited axial shifting stroke (a) with a cylinder-piston-aggregate, for example a valve (18), it is proposed to intermittently subject the cylinder-piston-aggregate to the action of pressurized fluid, thus exposing the bit (24) during its engaging the rock to percussion forces. During the phases lacking any action of pressurized fluid onto the cylinder-piston-aggregate, the bit (24) shall be pushed into its starting position. This embodiment can be realized with both hydraulic and pneumatic cylinder-piston-aggregates, noting that in case of an embodiment having a hydraulic cylinder-piston-aggregate it is preferred to design this cylinder-piston-aggregate as a valve (18) which simultaneously provides the possibility to expel pressurized liquid via a spraying nozzle (32) onto the mine face. (FIG.
Patent RU-94003453-A (RU)
Inventor: LYSENKO S V
IPC: A61H21/00
Filed: 1994-01-28
Abstract: FIELD: medicine, in particular, prostate treatment. SUBSTANCE: apparatus has casing 1 with spring mechanism 5 and handle 6. Working member 2 is mounted in casing 1 for reciprocating along its axis. Casing 1 and working member 2 are interconnected by spring mechanism 5 and handle 6. Casing 1 has restricting stop 7 adjustable along its axis. Head of working member 2 is made spherical, with smooth transition portion integral with cylindrical working member 2 having lesser diameter as compared to that of spherical portion. EFFECT: increased efficiency and intensified prostate treatment.
Patent RU-94023753-A (RU)
Inventor: MAKARYCHEV A V
IPC: G06F19/00
Filed: 1994-06-23
Abstract: FIELD: automated control systems; equipment for automated control over troops and may be used in automated control systems of Air Defence Forces. SUBSTANCE: invention is based on task of design of such gear that can calculate both depth and width of region of probable location of target for any specified probability of presence of target in region of probable location with hypothesis of uniform law of distribution both speed and flight heading of target. Essence of invention consists in insertion of known gear incorporating unit for setting of starting data, eight multipliers, four adders, two dividers, two square root computers and subtracter with new units including eight multipliers, two dividers, two subtracters, two square root computers, two sine computers, two additional outputs of unit for setting of starting data, couplings between specified units and elements of gear. EFFECT: increased authenticity of calculation of depth and width of probable location of target.
Patent RU-94028517-A (RU)
Inventor: BUGAKOV I A
IPC: G01K7/00
Filed: 1994-07-27
Abstract: FIELD: measurement technology. SUBSTANCE: proposed method of temperature measurement of object is based on registration of temperature increment of temperature-sensitive element within bounds of specified time interval and of integral of this temperature. Method shows high speed and accuracy, expands measurement range which makes it possible to employ this method in various branches of science and technology. EFFECT: high-speed, accuracy and expanded application field of this method.
Patent RU-94036154-A (RU)
Inventor: SMIRNOV G G
IPC: A44C17/00
Filed: 1994-09-27
Abstract: FIELD: jewelry. SUBSTANCE: method of making of jewel with agate is offered, in which a pair of miniature multi-colored halves or plates, mainly one-piece agates, of different patterns harmonizing with one another are selected as stone. EFFECT: improved quality. 1 dwg