baber/WOPTO huggingface dataset:
Patent IE-58860-B1 (IE)
Title: Method for recovering purified growth hormones from genetically engineered microorganisms
IPC: A61K35/74
Filed: 1985-08-26
Abstract: This invention concerns a method for recovering a purified eucaryotic growth hormone or an analog thereof from a bacterial cell in which the growth hormone or analog has been produced by means of expression of a DNA sequence encoding the hormone or analog. The method involves the following steps: (a) disrupting the cell wall of the bacterial cell or fragments thereof to produce a lysate; (b) separating a precipitate containing particulate and insoluble material from the lysate; (c) preparing suspension of the separated precipitate in an appropriate buffer solution; (d) treating the suspension to effect contact between liquid and solids; (e) separating partially or completely precipitated material from the liquid-solids contacted suspension; (f) solubilizing the separated precipitate in a sufficient amount of water and adjusting the pH to a suitable alkaline pH to form a solution; (g) separating the solubilized hormone or analog from other cellular components by ultrafiltration under suitable conditions to produce an ultrafiltrate containing the hormone or analog and a retentate, and (h) treating the solubilized hormone or analog so as to concentrate the hormone or analog and thereby recover purified hormone or analog. Separations may be effected by ultrafiltration or centrifugation. Sonication as well as the ultrafiltration in step (i) may be repeated. Additionally, most of the process steps may be performed in a continuous flow and may be automated. Suitable hormone-producing bacterial cells for use in this invention include genetically modified strains of Escherichia coli. Growth hormones which can be recovered and purified using this invention include bovine, porcine, chicken, and human growth hormones, and analogs thereof.
Patent IE-64000-B1 (IE)
Title: Blood recovery system
Inventor: VASCONCELLOS ALFRED V
IPC: A61M1/02
Filed: 1989-07-17
Abstract: An intraoperative blood recovery system and method for salvaging operative blood while simultaneously delivering previously collected blood to a reinfusion system. A blood collection and transfer reservoir (10), having multiple compartments (20) (22) (24) which can be separated by vacuum or pressure barriers, is designed to maintain a continuous suction for blood inflow while blood previously collected can be simultaneously transported through the reservoir to achieve an uninterrupted flow of blood into and delivery of blood out of the reservoir.
Patent IE-64400-B1 (IE)
Title: Aqueous pharmaceutical suspension for substantially water insoluble pharmaceutical actives
Inventor: GOWAN WALTER G JR
IPC: A61K31/192
Filed: 1990-06-27
Abstract: The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water insoluble pharmaceutical active, e.g. ibuprofen; a suspension stabilizing effective amount of xanthan gum, pregelatinized starch and polyoxyethylene sorbitan monooleate; an effective amount of taste masking composition; and water, as well as a process for producing such aqueous pharmaceutical suspensions.
Patent IE-51766-B1 (IE)
Title: Apparatus for controlling discharge of flowable material from a store thereof,such as a silo
IPC: B65G69/18
Filed: 1981-10-07
Abstract: The invention relates to apparatus 1 for controlling discharge from a store thereof such as a silo 4, the apparatus 1 including a conical device 2 which supports on its undersurface a vibrator 7 and which is itself supported via isolators 11 on cross-beam 10. The maximum diameter of the free edge of the device 2 is less than the internal diameter of an opening 3 from the silo 4 and defines with that opening an annular flow path 9 through which material (not shown) above the device 2 flows when the vibrator 7 is vibrated, as vibrating the device 2 to initiate flow of material through the path 9.
Patent IE-57986-B1 (IE)
Title: Enkephalinase inhibitors
IPC: A61K31/16
Filed: 1984-10-01
Abstract: New mercaptoalkanoyl and acylmercaptoalkanoyl compounds of the formula wherein R1, R2, R3 and R4 are as defined herein and n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.
Patent IE-75724-B1 (IE)
Title: Cell-free receptor binding assays the production and use thereof
Inventor: LAUFFER LEANDER
IPC: G01N33/68
Filed: 1991-11-27
Abstract: The invention relates to cell-free receptor binding tests which permit investigation of the binding characteristics of receptor proteins which are located in the cell membrane towards natural or synthetic ligands. These entail the particular receptor being linked to a suitable carrier molecule, preferably the heavy chain of an immunoglobulin, and being bound to a suitable solid phase via the carrier while retaining its biological properties. <IMAGE>
Patent JP-3022540-B1 (JP)
Title: ゲ―ム機
IPC: A63F7/02
Filed: 1999-01-08
Granted: 2000-03-21
Abstract: 【要約】
【課題】  盤面部に設けられたチャッカーを活用してゲ ームに様々な変化を与えることが可能なゲーム機を提供 する。
【解決手段】  遊技体としてのメダルが通過可能な複数 のチャッカー４１を有する盤面部２０と、チャッカー４ １のそれぞれに対するメダルの通過を検出するセンサ と、チャッカー４１のそれぞれに対応付けて情報を表示 可能なモニタ装置とを備えたゲーム機において、センサ によるメダルの通過の検出に応答して、複数の選択肢の なかからいずれか一つの選択肢をその通過が検出された チャッカーの属性として割り当てるとともに、その属性 の割り当て結果を示す情報が表示されるようにモニタ装 置２３を制御する。所定のプレイ範囲内におけるチャッ カー４１のそれぞれに関するメダルの通過または不通過 の状態と、メダルが通過したチャッカー４１に割り当て られた属性とに基づいて、プレイヤーに対する報酬を決 定する。
Patent LU-502373-B1 (LU)
Title: Method for preparing agar with low melting point
Inventor: YANG XIANQING
IPC: C08B37/12
Filed: 2022-06-28
Granted: 2022-12-29
Abstract: The application discloses a method for preparing agar with low melting point, which comprises the steps: Taking a mass of agar, adding an ethanol solution, adjusting the pH to pH8.0-pH10.0, adding a 30% hydrogen peroxide solution, reacting at a constant temperature of 20-30℃, adjusting the ph to be neutral, dispersing the filter residue with 50-60% ethanol; (2) adding the obtained agar into an ethanol alcohol solution with the same volume as in step (1), adding sodium hydroxide, and stirring at a temperature between 40 and 45℃ until the sodium hydroxide is dissolved; (3) adding sodium hydroxide with the same amount as in step (2), and adding chloroacetic acid or sodium chloroacetate; (4) putting the mixture of step (3) into a microwave reactor, adjusting the microwave power to 300-500 W, the temperature to 45-60℃ and the reaction time to 35-60 min; (5) performing suction filtration.
Patent NO-301768-B1 (NO)
Inventor: CERLETTI NICO
IPC: C12P21/02
Filed: 1990-12-05
Abstract: The invention relates to a process for the production of biologically active, dimeric TGF- beta , to novel TGF- beta s and pharmaceutical compositions comprising it. TGF- beta produced by this process can be used in various therapeutic modalities.
Patent NO-302767-B1 (NO)
Inventor: HOLTINGER LILLEMOR
IPC: D21C9/16
Filed: 1994-04-19
Abstract: In a method for bleaching lignocellulose-containing pulp with a peroxide-containing compound, the pulp is, prior to the bleaching and in optional order, subjected to acid treatment at a pH of up to about 5 and treated with a complexing agent in order to release transition metal ions from their positions in the pulp. After the acid treatment, a magnesium compound and a calcium compound are added to the pulp at a pH of from about 3.5 to about 8 in order to reintroduce an optimum amount of magnesium and calcium ions into the pulp. The pulp is then bleached with a peroxide-containing compound at a pH of from about 7 to about 13.
Patent NO-305596-B1 (NO)
Inventor: ARMISTEAD DAVID M
IPC: C07D239/00
Filed: 1995-03-27
Abstract: The present invention relates to novel compounds of formula (I) which maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance and for use in multi-drug resistant cancer therapy.
Patent NO-312868-B1 (NO)
Title: Tilkoblingsinnretning for knivklemme
Inventor: ACKE EDGAR
IPC: H01R13/646
Filed: 1995-09-27
Abstract: En knivklemmetilkoblingsinnretning for en utvendig leder er kjennetegnet ved organer (9; 106) for knivklemmetilkoblingen og som kan stikkes inn i utsparinger (13) på et hus (1) og er utført på en slik måte at de ved innstikking i utsparingen (13) skjærer gjennom den ytre, isolerende kabelkledning (7) til en der innført koaksialkabel og kontakterer kabelens utvendige leder (4) og er selvklemmende festet i utsparingen i den i utsparingene (13) innsatte tilstand. En knivklemmetilkoblingsinnretning for en innvendig leder er kjennetegnet ved at en første elektrisk leder (102,102a) som skal forbindes, har en utsparing (102b) som er utført og dimensjonert på en slik måte at en annen elektrisk leder (107a) som skal forbindes, hovedsakelig motstandsløst kan føres inn i denne, og at fra denne utsparing (102b) utgår knivklemme-kontakteringsseksjonen i form av en klemsliss (102c). En isolasjonsdel til støtte og sentrering i en utvendig leder av en innvendig leder som fører til knivklemmetilkoblingsinnretningen er kjennetegnet ved at støttesoner (103c) til støtte av isolasjonsdelen i den utvendige leder har en eller flere flate-seksjoner (103d) som med hensyn til overflatenormalen til den innvendige leder (102,102a) strekker seg skrått.
Patent NO-305781-B1 (NO)
Inventor: LANSBERRY JOHN B
IPC: A01G23/09
Filed: 1995-11-10
Abstract: An apparatus (10) for severing a standing tree (48) at a trunk portion thereof includes a housing (12) constructed and arranged to be movable to a tree harvesting location. Holding structure (18) is constructed and arranged with respect to the housing (12) to hold a portion of the stem of the tree while the trunk portion thereof is severed. A cutting blade (32) mounted so as to be movable between retracted and extended position with respect to the tree. Impact hammer structure (38) is operatively coupled to the cutting blade (32) such that successive impacts generated by the impact hammer structure (38) on the cutting blade (32) move the cutting blade (32) progressively through the trunk portion of the tree (48). Actuating structure (30) is operatively associated with the cutting blade (32) and constructed and arranged to move the cutting blade (32) between its retracted and extended positions such that when the cutting blade (32) is in an extended position and in engagement with the trunk portion while the holding structure (18) holds the stem of the tree (48), the successive impacts move the cutting blade to sever the standing tree (48).
Patent NO-307235-B1 (NO)
Inventor: MCCONNELL GARY A
IPC: G06F3/033
Filed: 1998-05-18
Abstract: PCT No. PCT/NO97/00254 Sec. 371 Date Oct. 18, 1998 Sec. 102(e) Date Oct. 18, 1998 PCT Filed Sep. 18, 1997 PCT Pub. No. WO98/12661 PCT Pub. Date Mar. 26, 1998An authenticated personal signature is stored in the database which can be compared to a newly presented signature for validation. The method for registering, analyzing and validating the hand-written personal signature requires that the signature be written in an x, y plane with a writing instrument which has a multiaxis movement detector at its end. The multiaxis movement detector detects the movement of said writing device as a function of time and with six degrees of freedom. The six degrees of freedom given by a linear movement along an x-axis, a y-axis and a z-axis, respectively, as well as by rotation about said x-axis, said y-axis and said z-axis, respectively. The six degrees of freedom of the writing instrument are recorded in predetermined formats in a database. A newly registered personal signature that is presented for validation is compared with the stored authenticated personal signature in the database.
Patent NO-319946-B1 (NO)
Inventor: HUNTER WILLIAM L
IPC: A61K33/24
Filed: 1998-11-23
Abstract: The present invention provides methods for treating or preventing vascular diseases associated with narrowing or obstruction of a blood vessel, comprising the step of delivering to an external portion of the body passageway an anti-angiogenic factor.
Patent NO-326653-B1 (NO)
Inventor: BUSCHMANN MICHAEL D
IPC: A61B5/296
Filed: 1999-08-06
Abstract: The present invention relates to a medical apparatus for the early detection and the diagnosis of cartilage degeneration and a method for using such apparatus. The apparatus comprises at least two point electrodes, a signal processor located in proximity of the electrodes, a defined abutment in recess of the electrodes for allowing compression of the cartilage against the electrodes until the cartilage abuts against the abutment surface and a computer program for analyzing and interpreting the data received from the electrodes. The medical apparatus may be used in research to identify effects of new compounds or drugs on the cartilage or may be used in clinics to monitor the degradation of cartilage of a patient over an extended period of time.
Patent AT-504713-B1 (AT)
Title: Vorrichtung zum applizieren von gespeicherten frequenzinformationen
IPC: A61N2/02
Filed: 2007-06-19
Granted: 2011-02-15
Abstract: Die Erfindung betrifft eine Vorrichtung zum Applizieren von gespeicherten Frequenzinformationen in Form von modulierten Magnetfeldern und/oder moduliertem Licht auf den Körper mit einer Anzeige (2), einem Speicher, einer Steuerelektronik, einem D/A-Wandler sowie einer Spule (6) zum Applizieren der modulierten Magnetfelder und/oder einem Laser (7) zum Applizieren des modulierten Lichtes, wobei die Vorrichtung mindestens zwei, vorzugsweise drei Sensoren (4) zur Messung des elektrischen Potentials des Herzens sowie mindestens einen Sensor (5) bevorzugt in Form eines Phototransistors, zur Messung des Pulswertes umfasst, wobei von der Steuerelektronik der Vorrichtung die von den Sensoren empfangenen Signale zur Berechnung einer Herzartenvariabilitäts-Herzkohärenz-Analyse verarbeitbar und das Ergebnis auf der Anzeige (2) der Vorrichtung anzeigbar ist.
Patent BG-61076-B1 (BG)
Title: 1-aryl-5-(substituted alkylidenimino) pyrazols having pesticide activity
Inventor: HUANG JAMIN
IPC: C07D401/12
Filed: 1992-04-30
Abstract: Pyrazoles of formula (I) are new. In (I), R1 = CN, NO2, halo, formyl, alkycarbonyl or cycloalkylcarbonyl; R2 = halo, alkyl, haloalkyl, alkoxy, haloalkoxy, NO2, thiocyanate, (or optd. mono- or di-alkyl substd.) sulphamoyl, or aminocarbonyl, alkoxycarbonyl or opt. substd. R9S(O)n; n = 0 to 2; R9 = alkyl, haloalkyl, cycloalkyl, halocycloalkyl, cyclo-alkyl- alkyl or halocycloalkyl alkyl; R3 = H, alkyl, alkoxy, alkylthio or di alkylamino; R4 = phenyl or 5-6 membered O,S and/or N, heteroaryl both opt. substd with -OH or a salt, -SH or a salt, halo, CN, NO2, alkyl, haloalkyl, alkoxy, -O- alkyl-O-, -O-halo alkyl-O-, haloalkoxy, alkanoyloxy, phenolic, tri-alkylsiloxy, phenyl, alkyl-S(O)n, halo alkyl-S(O)n, NR10R11, COR12, SO2R13; R10,R11 = H, alkyl, alkanoyl or haloalkanoyl; R12 = NR10R11 alkoxy, alkylthio, OH or a salt, H, alkyl or halo alkyl; R13 = NR10R11, alkoxy, alkylthio or OH or a salt; R5 = halo or alkyl; R6, R8 = H or F; R7 = H, alkyl, haloalkyl, alkoxy, haloalkoxy, CN, NO2, alkylcarbonyl, haloalkylcarbonyl, alkyl-S(O)n or halo alkyl-S(O)n; X = N or CR14; R14 = H, halo, CN, NO2, alkyl, alkylthio or alkoxy; where alkyl = 1-4C alkyl and cycloalkyl = 3-7C cycloalkyl. 17 Cpds. (I) are claimed e.g. 1-(2,6-dichloro-4-trifluoro methyl phenyl)-3-cyano-4- trifluoromethylsulphenyl-5- (4-hydroxy-3-methoxyphenyl) methylideneimino)pyrazole (Ia).
Patent BG-60969-B1 (BG)
Title: Dextrine paste
Inventor: IVANOV IVAN S
IPC: C09J11/00
Filed: 1993-07-15
Abstract: The dextrine paste is used for gluing papers, cardboards, packaging and labels on metallic or glass bottling containers. It forms a fully transparent film, includes no impurities or abrasive particles, has poor thixotropy and lasting gluing properies. The composition contains, in wt.%: from 20 to 65 enzymically produced dextrine, borax from 0.5 to 4.5, carbamide from 0.5 to 12, glucose from 0.5 to 5, sugar from 0.1 to 4, polyethyleneglycol 0.01-1, caprolactam 0.01-0.5, bentonite 0.1-3, preservative 0.01-0.5 and water to 100.
Patent BG-62466-B1 (BG)
Title: Installation for mussel growing
Inventor: PARLICHEV DIMITAR G
IPC: A01K61/02
Filed: 1994-12-06
Abstract: The installation is used in hydrobiology. It has simplifiedcompact design having also the quality of a wave stilling device.The installation is a metal or reinforced concrete structureconsisting of three of more vertical supports (1) interconnectedby upper (3,   5) and lower (4,  6) horizontal profile beamsbetween which a large number of collector ropes (14) are stretchedby means of double upper hooks (15) and lower hooks (18). Thestationary option of the installation is used in the coastal areausually at a depth of from 3 to 7 m, in and at greater depths insubaquatic position, and its flaoting option - along the wholeaquatory of the shelf. When platform (11) is fitted by means ofpipes (10) on supports (1) the installation becomes an artificialisle for recreational purposes.2 claims, 4 figures
Patent BG-61951-B1 (BG)
Title: Effect thread and a method for its manufacture
Inventor: STOJANOV JORDAN J
IPC: D06Q1/00
Filed: 1995-06-02
Abstract: The invention relates to an effect thread consisting of alongitudinal supporting structure to which two-side fitted effectcuts are connected to it in the manner for producing large -surface textile products, one of its ends of which at least comesout to the surface of the longitudinal supporting structure andwhich occupies a free position in space. It has a trapeze-shapedcross section made by the cuts of the effect cuts the free ends ofwhich have been obliquely cut to the longitudinal supprtingstructures fitted in its interior. The method for its manufactureconsists in longitudinal cutting of a large-surface textileproduct.2 claims, 1 figure
Patent BR-0009985-B1 (BR)
Inventor: KINISKY THOMAS G
IPC: B24B49/12
Filed: 2000-04-10
Abstract: Provision of a rotatable abrasive disk having apertures permitting a view of a workpiece surface during the abrading process makes possible the incorporation of a condition sensing mechanism viewing the workpiece surface through the holes and capable of adapting the grinding conditions accordingly.
Patent BR-0208737-B1 (BR)
Inventor: ZERRER RALF
IPC: A01N25/10
Filed: 2002-04-06
Abstract: The present invention relates to aqueous concentrates and solid formulations of pesticide preparations comprising copolymers which may be obtained by copolymerization of a) glycerol, b) at least one dicarboxylic acid, and c) at least one monocarboxylic acid of the formula (I) <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>1</SUP>-COOH (I)<?in-line-formulae description="In-line Formulae" end="tail"?> Where R<SUP>1 </SUP>is (C<SUB>5</SUB>-C<SUB>29</SUB>)-alkyl; (C<SUB>7</SUB>-C<SUB>29</SUB>)-alkenyl; phenyl or naphthyl. The copolymer of the present invention increases the biological activity of the pesticide or herbicide.
Patent BR-PI0316808-B1 (BR)
Title: cateter
Inventor: MCMICHAEL DONALD J
IPC: A61F2/958
Filed: 2003-10-29
Abstract: "cateter com componente unitário". um componente unitário que tem uma porção de ponta formada integralmente com uma porção de luva expansível. outros aspectos da presente invenção estão relacionados com um cateter que incorpora um componente unitário. ainda outros aspectos da presente invenção serão evidentes após leitura do restante da descrição.
Patent CH-717172-B1 (CH)
Title: Pièce d'horlogerie destinée à afficher avec les mêmes aiguilles l'heure courante ou une fonction chronographe.
Inventor: LUDOVIC BALLOUARD
IPC: G04B19/02
Filed: 2020-02-27
Abstract: L'invention concerne une pièce d'horlogerie (1) destinée à l'affichage alternatif de l'heure courante et d'une complication dite de chronographe à partir d'aiguilles comprenant un mécanisme qui comprend un sous ensemble d'affichage, un râteau palpeur muni d'un palpeur et un sous ensemble moteur, le sous ensemble d'affichage comprenant un mobile de minuterie, le sous ensemble moteur comprenant deux bascules montées pivotantes selon un débattement limité, équipées chacune d'un train de rouage, l'une desdites bascules comprenant à l'extrémité libre de son train de rouage une came, l'autre desdites bascules comprenant à l'extrémité libre de son train de rouage une roue de chronographe, le palpeur étant destiné à être entrainé par la came, et l'extrémité libre du râteau palpeur étant destinée à engrener le mobile de minuterie du sous ensemble d'affichage pour l'affichage de l'heure courante, la roue de chronographe étant destinée à entrainer le mobile de minuterie du sous ensemble d'affichage pour l'affichage de la fonction chronographe, le maniement d'au moins un bouton poussoir (11) sollicitant le fonctionnement alternatif des bascules pour l'affichage de l'heure courante ou de la fonction chronographe.
Patent CH-702889-B1 (CH)
Inventor: CHANG HUANG-TUNG
IPC: A63B22/02
Filed: 2011-02-28
Abstract: Eine Dämpfungsplatte (4´´) für ein Laufband beinhaltet einen Bambusstreifenteil und eine Gleitplatte (2). Der Bambusstreifenteil ist aus mindestens zwei longitudinalen Bambusstreifen (11) und mindestens zwei quer gerichteten Bambusstreifen (12) zusammengesetzt. Die longitudinalen Bambusstreifen (11) und die quer gerichteten Bambusstreifen (12) sind kreuzweise verflochten, um eine geflochtene Bambusplatte zu bilden. Die geflochtenen Bambusplatten können aufeinandergestapelt werden, um einen Stapel von geflochtenen Bambusplatten in der gewünschten Dicke zur Erhöhung der Festigkeit der Dämpfungsplatte (4´´) zu bilden. Die seitlich verbundenen longitudinalen Bambusstreifen (11) und die seitlich verbundenen quer gerichteten Bambusstreifen (12) sind gestapelt, um eine laminierte Bambusplatte (3) zu bilden. Die obere geflochtene Bambusplatte oder die laminierte Bambusplatte (3) ist mit der Gleitplatte (2) verbunden. Nachdem eine Anpresskraft ausgeübt wurde, ist die Oberfläche der Gleitplatte (2) mit einer konkav-konvexen Massage-Kontur geformt, die mit der Kontur der geflochtenen Bambusplatte oder der laminierten Bambusplatte (3) übereinstimmt. Die aus der geflochtenen Bambusplatte oder der laminierten Bambusplatte (3) oder beiden zusammengesetzte Dämpfungsplatte (4´´) bietet einen besseren Dämpfungseffekt und einen Fuss-Massageeffekt.
Patent CH-702409-B1 (CH)
Inventor: HAEMMERLE MARTIN
IPC: G01L9/00
Filed: 2004-05-26
Abstract: Ein Differenzdrucksensor (1) umfasst ein Gehäuse, in welchem zwei Membranen (40) angeordnet sind, die jeweils zwei Druckkammern (70, 71, 72, 73) voneinander trennen. Das Gehäuse ist durch Einzelplatten (20, 21, 22, 23, 24, 25, 26) einer Multilayer-Leiterplatte gebildet. Durch eine solche Ausgestaltung des Gehäuses werden wesentliche Elemente des Differenzdrucksensors (1), wie beispielsweise die Membranen (40) und die Druckkammern (70, 71, 72, 73), in die Multilayer-Leiterplatte integriert und es entsteht ein äusserst kompakter und robuster Differenzdrucksensor (1).
Patent DE-2510016-B1 (DE)
Title: Inlet funnel or coolant pump - incorporated in the steam generator of a pressure water nuclear reactor
Inventor: BERGLOEFF DAG DIPL-ING
IPC: G21C15/243
Filed: 1975-03-07
Abstract: In a pressure water reactor in which not only the steam generator but also the primary circuit piping incorporating the primary coolant circuit pump are installed outside the reactor pressure vessel and a safety envelope encloses the pressure vessel, steam generator, primary circuit piping and coolant pump, which is in turn built into the housing of the associated steam generator, generally ad disclosed in the parent. Application, the further improvement whereby the pump has a curved unsymmetrical funnel-shaped inlet on the suction side directed towards a tube plate for the reception of the ends of a tube bundle, which together with the tube plate delimits inlet and outlet chambers for the primary coolant. Enables the advantages of the parent Patent to be retained, while solving the problem of the sharp transition between the subdivided flow through the tube plates and steam generator and the concentrated flow in the pump, with minimum consumption of material.