baber/WOPTO huggingface dataset:
Patent NZ-242862-A (NZ)
Title: Thioxanthenone antitumor compounds and compositions thereof
Inventor: COLLINS JOSEPH CHARLES
IPC: A61K31/38
Filed: 1992-05-22
Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones having the formula <CHEM>  wherein n is 2 or 3;     R<1> and R<2> are independently lower-alkyl; Q is a residue chosen from the group consisting of CH2NHR<3>, CH2N(R<4>)SO2R<7>, CH2NHCHO, CH=N-Ar, C(O)NR<5>R<6>, CH2N(R<4>)C(O)R<7>, CH2N(C2H5)CHO, and CH2N(R<4>)P(O)(O-lower-alkyl)2;     R<3> is hydrogen or lower-alkyl;     R<4> is hydrogen or lower-alkyl;     R<5> is hydrogen, lower-alkyl or Ar;     R<6> is hydrogen or lower-alkyl;     R<7> is lower-alkyl, or Ar;     R<8> is hydrogen, lower-alkyl, lower-alkoxy, or halogen; and Ar is phenyl or phenyl substituted with methyl, methoxyl, halogen or nitro; or a pharmaceutically acceptable acid-addition salt or solvate thereof, are disclosed as antitumor agents. Compositions containing the thioxanthenones and the method of use of thioxanthenones for treating tumors and cancer in mammals are also disclosed.
Patent NZ-250712-A (NZ)
Title: Using dehydroepiandrosterone (dhea), its sulphate (dhea-s), or compounds convertible thereto for contraception, treating menopausal symptoms or cosmetic imbalances of sex steroids
Inventor: LABRIE FERNAND
IPC: A61K31/57
Filed: 1994-01-19
Abstract: Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment and/or prevention of vaginal atrophy, hypogonadism, diminished libido, osteoporosis, urinary incontinence, ovarian cancer, uterine cancer, skin atrophy, for contraception, and, in combination with an estrogen and/or progestin, for the treatment of menopause. The precursors may be formulated for percutaneous or transmucosal administration. Gels, solutions, lotions, creams, ointments and transdermal patches for the administration of these precursors are provided, as are certain pharmaceutical compositions and kits which can be used for the prevention and treatment of a wide variety of conditions related to decreased secretion of sex steroid precursors by the adrenals.
Patent NZ-252132-A (NZ)
Title: Rectal medicaments containing a 5ht1 receptor agonist (eg certain indole-5-sulphonamide derivatives) and a hard fat base carrier with a hydroxyl value > 15
Inventor: MERLET NADINE
IPC: A61K31/445
Filed: 1993-05-03
Abstract: PCT No. PCT/EP93/01077 Sec. 371 Date Dec. 29, 1994 Sec. 102(e) Date Dec. 29, 1994 PCT Filed May 3, 1993 PCT Pub. No. WO93/21916 PCT Pub. Date Nov. 11, 1993The present invention relates to a pharmaceutical composition for rectal administration in solid dosage form which comprises a compound acting as a 5HT-1 like receptor agonist in the form of its free base or a physiologically acceptable hard fat base carrier having a hydroxyl value of more than 15 in the method for the treament of a mammal suffering from a susceptible to conditions associated with cephalic pain.
Patent NZ-254784-A (NZ)
Title: Substituted 5-phenyl pyrrole derivatives and medicaments
Inventor: STEMP GEOFFREY
IPC: A61K31/4025
Filed: 1993-07-29
Abstract: PCT No. PCT/EP93/02030 Sec. 371 Date Feb. 3, 1995 Sec. 102(e) Date Feb. 3, 1995 PCT Filed Jul. 29, 1993 PCT Pub. No. WO94/03426 PCT Pub. Date Feb. 17, 1994.Compounds of formula (I),    <IMAGE>  formula (I)   <IMAGE>  (a)  or   <IMAGE>  (b)  wherein R1 represents C1-4alkyl; and R2, R3, R4 and R5 each independently represent hydrogen, halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C1-4alkylsulphonyl, trifluoromethylsulphonyl; optionally substituted arylsulphonyl, optionally substituted heteroarylsulphonyl, optionally substituted aralkylsulphonyl, optionally substituted heteroaralkylsulphonyl, nitro, cyano, amino, mono- or di-alkylamino, trifluoromethyl, trifluoromethoxy, hydroxyl, hydroxyalkyl, C1-4alkylthio, C1-4alkanoyl, C1-4alkoxycarbonyl, aminosulphonyl, alkylaminosulphonyl or dialkylaminosulphonyl; or R1 and R2 together form a linking chain-(CH2)mOp (wherein m is 2 to 4 and p is zero or 1) which chain may be optionally substituted by one or two C1-4alkyl groups; and Y represents a group selected from (a) or (b) wherein R6 and R7 independently represent hydrogen, C1-6alkyl, optionally substituted arylC1-6alkyl or optionally substituted heteroarylC1-6alkyl; R8 represents C1-6alkyl, C3-6alkenyl or C3-6cycloalkylC1-4alkyl; and R9 represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; or NR8R9 forms a heterocyclic ring (with the proviso that NR8R9 is not piperazine); R10 represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl, or optionally substituted heteroarylC1-4alkyl; and n is 1 to 3; and salts thereof, have affinity for dopamine D3 receptors and may be useful in the treatment of e.g., psychotic disorders.
Patent NZ-255853-A (NZ)
Title: Chemiluminescent label compound containing a biotin moiety; diagnostic assay and kit
Inventor: REMAKRISHNAN KASTOORIRANGANATH
IPC: G01N33/58
Filed: 1993-08-19
Abstract: A unique class of chemiluminescent labels containing biotin substitution that are suitable for chemiluminescent assays using inter alia a streptavidin and/or avidin conjugate. The chemiluminescent labels of the invention have the ability to bind to streptavidin and/or avidin per se or to streptavidin and/or avidin conjugated with an analyte. Label structures are disclosed that have hydrolytic stability to meet the most demanding commercial assay conditions. The invention encompasses conjugates containing associated versions of the labeling compounds, assays and kits for performing such assay utilizing the conjugates.
Patent NZ-268110-A (NZ)
Title: Use of ropivacaine salt in pharmaceutical compositions for the treatment of pain with sensoric block and minimal motor blockage
Inventor: EEK ARNE TORSTEN
IPC: A61K31/445
Filed: 1994-05-26
Abstract: PCT No. PCT/SE94/00496 Sec. 371 Date Jun. 28, 1994 Sec. 102(e) Date Jun. 28, 1994 PCT Filed May 26, 1994 PCT Pub. No. WO95/00148 PCT Pub. Date Jan. 5, 1995Use of a pharmaceutically acceptable salt of ropivacaine for the manufacture of a pharmaceutical preparation with sensoric block and minimal motor blockade.
Patent NZ-270639-A (NZ)
Title: Formulation for increasing liveweight gain in livestock comprising selenium and an ionophore antibiotic
Inventor: LOWE LIONEL BARRY
IPC: A23K20/195
Filed: 1995-03-06
Abstract: This invention relates to a formulation for increasing weight of livestock comprising an ionophore, selenium and a veterinary acceptable carrier, diluent, excipient and/or adjuvant. The invention also relates to a method of increasing liveweight gain in livestock comprising, administering to said livestock an effective amount of a formulation of the invention. The invention further relates to a method of increasing selenium absorption in livestock comprising, administering to said livestock an effective amount of an ionophore.
Patent NZ-295673-A (NZ)
Title: Nucleic acid transfer system using recombinant multi-domain proteins each domain having a different function
Inventor: FOMINAYA JESUS
IPC: C12R1/19
Filed: 1995-10-31
Abstract: The invention pertains to a nucleic acid transfer system including a translocation domain of toxins, especially of diphtheria toxin suitable for targeting a nucleic acid, e.g. a gene, to a specific cell, and obtaining expression of said nucleic acid. The nucleic acid transfer system of the invention comprises a multidomain protein component and a nucleic acid component. Furthermore, the present invention relates to the multidomain protein, a nucleic acid encoding said protein, suitable amplification and expression systems for said nucleic acid, and processes for the preparation and uses of the above subject matters.
Patent NZ-318909-A (NZ)
Title: Fractionated vegetable oil
Inventor: HERSLOF BENGT
IPC: A23L29/10
Filed: 1996-09-13
Abstract: A new method for producing a fractionated vegetable oil from a plant material. The plant material is extracted with a non-polar solvent and the solvent is evaporated giving a crude oil which includes non-polar and polar lipids. The crude oil is mixed with an alcohol at a controlled temperature and a resulting alcoholic phase is separated and evaporated to recover a polar lipid rich fractionated vegetable oil. The invention also refers to the use of the polar lipid rich fractionated vegetable oil as a surface active agent.
Patent NZ-324337-A (NZ)
Title: Taxoids, preparation thereof and pharmaceutical compositions containing same
Inventor: BOUCHARD HERVE
IPC: A61K31/337
Filed: 1996-12-19
Abstract: Novel taxoids of the formula (I) shown, the preparation thereof and pharmaceutical compositions containing same, are disclosed. In the formula, Z is a hydrogen atom or a radical of general formula (II), wherein R1 is an optionally substituted benzoyl, furoyl or thenoyl radical or a radical R2-O-CO- where R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, phenyl, naphthyl or aromatic heterocyclic radical; or R4 is a hydrogen atom, R6 and R7 together form a ketone function, and R and R5 together form a bond; or R4 is a hydrogen atom or a hydroxy radical or an alkoxy, alkenyloxy, optionally substituted alkynyloxy, alkanoyloxy, aroyloxy, alkenoyloxy, alkynoyloxy, cycloalkanoyloxy, alkoxyacetyl, alkylthioacetyl, alkyloxycarbonyloxy, cycloalkyloxy, cycloalkenyloxy, carbamoyloxy, alkylcarbamoyloxy or dialkylcarbamoyloxy radical; R5 is a hydrogen atom, or R4 and R5 together form a ketone function, R6 is a hydrogen atom, and R and R7 together form a bond. The products of formula (I), wherein Z is a radical of general formula (II), are said to have remarkable antitumoral and antileukemic properties.
Patent NZ-334313-A (NZ)
Title: Colonic delivery of weak acid drugs through a controlled release formulation including pellets, each comprising an inner core, which comprises or is coated with a drug and a pH responsive membrane
Inventor: WATTS PETER JAMES
IPC: A61K9/58
Filed: 1997-10-06
Abstract: A controlled release composition including pellets, each comprising an inner core, which core comprises, or is coated with, a drug, which drug possess: (a) A free acid group which can be converted into an alkali metal salt; and (b) A pKa in the range 2.0 to 9.0, which inner core is subsequently coated with a rate-controlling membrane that determines drug release, wherein the drug (ridogrel) is present as a salt that displays solubility at pH 4.5 to 8.0 than the corresponding compound containing a free acid group, And wherein the composition is adapted to prevent release of the drug until the composition reaches the terminal ileum or the colon. The pharmaceutical composition is useful for the treatment of ulcerative colitis, Crohn's disease, irritable bowel syndrome, and inflammatory bowel disease.
Patent NZ-335658-A (NZ)
Title: Adjusting thresholds and measurements of signals received by mobile phone by anticipating power control commands yet to be executed
Inventor: SAINTS KEITH W
IPC: H04B7/005
Filed: 1997-11-13
Abstract: A mobile station or receiver adjusts its forward link quality or power level thresholds or measurements with which it compares incoming frames or portions of them to reflect the level it anticipates receiving.  For example, the mobile station can recognise that at a given measurement time, two outstanding messages have not been executed by the transmitter, where each message indicates a corresponding increase of 1 dB.  As a result, the mobile station can adjust its measurement threshold down by 2 dB to more closely correspond to future power adjustments.  If the currently received frame or a portion of it is still below the readjusted threshold, then the mobile station sends out a new message to request a further increase in the forward link channel.
Patent NZ-502223-A (NZ)
Title: A method for controlling growth of microorganism in an aqueous environment using 1,4-bis(bromoacetoxy)-2-butene
Inventor: LEE JAMES
IPC: A01N25/04
Filed: 1996-06-03
Abstract: An composition useful for controlling the growth of at least one microorganism in an aqueous system comprising 1,4-bis(bromoacetyoxy)-2-butene and a non-ionic emulsifier having a molecular weight of from about 500 to about 8,000 and a HLB value of from about 7 to about 20.
Patent NZ-505468-A (NZ)
Title: Dispensing apparatus torsion spring adjustment on handle
Inventor: MAIN JOHN ROBERT
IPC: A61D7/00
Filed: 2000-06-28
Abstract: Dispensing apparatus of a kind having a squeezing handle assembly which comprises or includes first and second handle components pivoted relative to each other on a pivot axis to move upon a squeezing together of such components, against a spring return bias to cause, in use, a piston discharge of a fluid from the barrel thereof, and to move, upon at least partial release of the squeeze on the handle, to cause a piston retraction.  Wherein the spring is a torsion spring having first and second arms each defined by an end of a coil, the coil being located by a pivot providing pin for the handle components that passes on the pivot axis through the spring coil with the second arm of the spring bearing on the second handle component and the first arm of the spring bearing on an adjacent mechanism carried by the first handle components, the adjacent mechanism enabling by movement of the first arm of the spring relative to the first component a change to the return bias provided by the torsion spring for the squeezable handle (6).
Patent NZ-508270-A (NZ)
Title: Recombinant secoisolariciresinol dehydrogenase, and methods of use
Inventor: XIA ZHI-QUIANG
IPC: C12Q1/68
Filed: 1999-04-23
Abstract: A secoisolariciresinol dehydrogenase protein has been isolated from Forsythia intermedia, together with cDNAs encoding secoisolariciresinol dehydrogenase from this species. Accordingly, isolated DNA sequences are provided which code for the expression of secoisolariciresinol dehydrogenase. In other aspects, the disclosed is directed to replicable recombinant cloning vehicles comprising a nucleic acid sequence which codes for a secoisolariciresinol dehydrogenase protein, or to a base sequence sufficiently complementary to at least a portion of a secoisolariciresinol dehydrogenase DNA or RNA to enable hybridisation therewith. Thus, systems and methods are provided for the recombinant expression of secoisolariciresinol dehydrogenases that may be used to facilitate the production, isolation and purification of significant quantities of recombinant secoisolariciresinol dehydrogenase for subsequent use, to obtain expression or enhanced expression of secoisolariciresinol dehydrogenase in plants in order to enhance, or otherwise alter, lignan biosynthesis, or may be otherwise employed for the regulation or expression of secoisolariciresinol dehydrogenase.
Patent NZ-511076-A (NZ)
Title: Method to mitigate plant stress by treatment with a composition containing gamma aminobutyric acid
Inventor: CRABTREE KRISTINE L
IPC: C05G5/23
Filed: 1999-10-05
Abstract: A method of mitigating the effects of plant stress comprising treating the plant with a composition containing an amount of gamma aminobutyric acid effective in mitigating plant stress, said plant being selected from cereals, crucifers, turf, duckweed and corn. The composition may also comprise a source of proteinaceous amino acid, such as glutamic acid, a protein hydrolysate, a yeast extract etc. and suitable carriers.
Patent NZ-512643-A (NZ)
Title: Improvements in and relating to humic compositions
Inventor: MURDOCH GAVIN FRANK
IPC: C09K17/50
Filed: 1999-12-03
Abstract: A humic composition which includes a clathratic, substantially water soluble cellulose component, or any synthetic or natural polymers, and which are substantially free of polyvalent cations. The composition is characterised such that when it is dissolved in water it remains substantially free of any gel-forming, but when polyvalent cations are introduced, it begins thickening. A method of applying the humic composition to a substrate such as a soil and a method of increasing humus in the substrate is also described.
Patent NZ-515555-A (NZ)
Title: Treatment of diabetes with thiazolidinedione and sulphonylurea
Inventor: SMITH STEPHEN ALISTAIR
IPC: A61P43/00
Filed: 1998-07-16
Abstract: A pharmaceutical composition comprising an insulin sensitiser, 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benyl]thiazolidine-2,4-dione (Compound(I)) and/or a pharmaceutically acceptable derivative thereof, a sub-maximal amount of an insulin secretagogue and a pharmaceutically acceptable carrier thereof which comprises 2 to 12 mg of Compound (I) for use in the treatment of diabetes mellitus and conditions associated with diabetes mellitus.
Patent NZ-520534-A (NZ)
Title: A chute propelled amusement ride with bungy aided free fall after the discharge point
Inventor: FEA DAVID BRUCE
IPC: A63B5/00
Filed: 2001-08-13
Abstract: The disclosure provides an apparatus for an amusement ride and fall. The apparatus comprises a track (10) having a discharge point below which there is a substantial drop. A thrill seeking passenger first experiences a ride by being propelled along a track (100) to the discharge point (20) and discharged there from with a horizontal component of motion. The passenger then experience a free fall. In a preferred embodiment, the passenger rides on or in a conveyance (42) releasably mounted on a carriage (34). The carriage (34) is propelled along the track (10) by propelling means (37) and at the discharge point (20) a substantial horizontal component of deceleration is imparted to the carriage (34) and enables the conveyance (42) and passenger to be discharged from the carriage (34) to continue in their own trajectory. In this embodiment the first end of the elastic tie (70) being secured to a carriage (34) that is not attached to the passenger but which travels with the passenger while the passenger is propelled along the track (10) and the second end of the elastic tie (70) being a free end directly or indirectly connected or connectable to the passenger, the elastic tie (70) limits the free fall of the connected passenger and, together with the horizontal component of motion imparted to the passenger, causes the passenger to bounce and swing for a period of time at the end of the free fall. At the end of the ride and fall the passenger is released safely. The disclosure therefore provides a thrill similar to that of a bungy or bungee jump.
Patent NZ-523948-A (NZ)
Title: Animal control system
Inventor: CROSS PETER STEPHEN
IPC: A01K11/00
Filed: 2003-01-30
Abstract: An animal control system includes a transducer assembly physically associated with the animal, a control unit, and an actuator assembly intimately associated with the animal. The control unit includes an assembly that includes "on-board" data, receives individual animal data from the transducer assembly, that data being the animal identity code plus an indication of the onset of oestrus for example, and assesses the received individual animal data with respect to historical individual animal data stored as on board data in the control unit. In accordance with the assessment a command is formulated in accordance with the individual animal data and transmitted to an actuator intimately associated with the animal. The command might be a command to an actuator to release a hormone to prime the animal for artificial insemination for example. The control unit is functionally separate from the actuator and transducer assemblies, meaning that the communication between the units is a messaging rather than direct data writing/reading communication.
Patent NZ-527916-A (NZ)
Title: Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
Inventor: HUNZIKER ERNST B
IPC: A61K35/32
Filed: 2002-01-30
Abstract: A composition comprising synovial tissue, synovial cells and matrices containing synovial tissue or cells for use in filling a cartilage defect. The matrix and synovial tissue or cell preparations may also contain an anti-proliferative agent, a transforming factor or other active agents to promote healing. The transforming factor may be associated with a controlled-release delivery system.
Patent NZ-531639-A (NZ)
Title: Use of milk serum apoproteins in the prophylaxis or treatment of microbial or viral infection
Inventor: FOLAN MICHAEL ANTHONY
IPC: A23L29/00
Filed: 2002-08-20
Abstract: Described is a pharmaceutically acceptable delivery system comprising at least one milk apoprotein or a mixture thereof in a pharmaceutically acceptable carrier. The composition can be used for inhibiting adhesion of potential pathogens in or on the surface of a human body. Preferably the composition also comprises at least one free fatty acid or a mixture thereof or a monoglyceride.
Patent NZ-533840-A (NZ)
Title: Double chamber pump with double action reciprocating manually operated driving levers
Inventor: MCNEIL GEORGE RODERICK
Filed: 2004-12-30
Abstract: A pump 60, especially constructed for ease of maintenance and use in places with undeveloped infrastructure, has a pair of diaphragms 1, 2 which are the working members of the pump, and a pump chamber 3, 4 associated with each diaphragm and each communicating via a respective check valve 32, 33 to a suction manifold 30 and via respective check valves 34, 35 to an outlet manifold 31. A drive mechanism 10 couples the diaphragms so that they reciprocate together and the first of the diaphragms performs an outlet stroke whilst the second diaphragm performs a suction stroke. The suction and outlet manifolds are part of a manifold assembly that connects the diaphragms for coordinated reciprocation. Manually operated levers 7, 8 are connected together for opposite reciprocation and are drivingly connected to the diaphragms.
Patent NZ-536633-A (NZ)
Title: Percutaneous delivery of testosterone via a hydroalcoholic gel as a method of increasing testosterone and related steroid concentrations in women
Inventor: DUDLEY ROBERT E
IPC: A61P25/28
Filed: 2001-08-29
Abstract: Disclosed is the use of a hydroalcoholic gel comprising testosterone, one or more alcohols, a penetration enhancing agent, a thickener and water, for the manufacture of a medicament for treating, preventing or reducing the risk of developing testosterone deficient disorder in a female mammal in need thereof. Methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a testosterone deficient disorder, or the symptoms associated with, or related to a testosterone deficient disorder in a female mammal in need thereof are also described. In addition, the methods, kits, combinations and compositions may be used in conjunction with other pharmaceutical agents effective at treating, preventing, or reducing the risk of developing a testosterone deficient disorder. The methods, kits, combinations and compositions can also be used in conjunction with a pharmacologically effective amount of an estrogenic hormone, for example, estradiol. Furthermore, the methods, kits, combinations and compositions can be used in conjunction with a pharmacologically effective amount of another steroid or pharmaceutical agent that increases serum testosterone levels in a mammal, for example, methyltestosterone.