baber/WOPTO huggingface dataset:
Patent DE-69310414-T2 (DE)
Inventor: STEIN PHILIP D
IPC: A61P15/00
Filed: 1993-02-23
Granted: 1997-12-11
Abstract: Compounds of the formula <CHEM>  inhibit endothelin, wherein: one of X and Y is N and the other is O; R is naphthyl or naphthyl substituted with R<1>, R<2> and R<3>; R<1>, R<2> and R<3> are each independently hydrogen; alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, or aralkyl, any of which may be substituted with Z<1>, Z<2> and Z<3>; halo; hydroxyl; cyano; nitro; -C(O)H; -C(O)R<6>; CO2H; -CO2R<6>; -SH; -S(O)nR<6>; -S(O)m-OH; -S(O)m-OR<6>; -O-S(O)m-R<6>; -O-S(O)mOH; -O-S(O)m-OR<6>; -Z<4>-NR<7>R<8>; or -Z<4>-N(R<1><1>)-Z<5><->NR<9>R<1><0>; R<4> and R<5> are each independently hydrogen; alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, or aralkyl, any of which may be substituted with Z<1>, Z<2> and Z<3>; halo; hydroxyl; cyano; nitro; -C(O)H; -C(O)R<6>; -CO2H; -CO2R<6>; -SH, -S(O)nR<6>; -S(O)m-OH; -S(O)m-OR<6>; -O-S(O)m-R<6>; -O-S(O)mOH; -O-S(O)m-OR<6>; -Z<4>-NR<7>R<8>; -Z<4>-N(R<1><1>)-Z<5><-> NR<9>R<1><0>; or R<4> and R<5> together are alkylene or alkenylene (either of which may be substituted with Z<1>, Z<2> and Z<3>), completing a 4- to 8-membered saturated, unsaturated or aromatic ring together with the carbon atoms to which they are attached.
Patent DE-69312226-T2 (DE)
Inventor: OLSON LEIF ALFRED INGEMAR
IPC: F24H1/26
Filed: 1993-11-17
Granted: 1997-11-13
Abstract: A heating boiler (10) which operates with flue-gas recirculation, said boiler comprising a water magazine (11) which is defined by an outer shell (12) and an inner shell (13) of circular cross-section, and two outer walls (25, 27) and a cylindrical combustion chamber (20) mounted inwardly of the water magazine (11) and comprising a plurality of surrounding flue-gas channels (17) which are mutually divided by longitudinally extending flanges (15) or the like disposed around the periphery of the circular inner shell (13) of the water magazine. The combustion chamber (20) is defined by a cylindrical pipe (16), a first combustion-chamber wall (18) which is connected to one end of said pipe and which is provided with a burner-accommodating opening, and a second combustion-chamber wall (19) connected to the other end of the pipe (16). The cylindrical pipe (16) is provided with a saddle-shaped outlet (22) which is located in the vicinity of said second wall (19) and which extends at most around half the circumference of the pipe (16). The outlet (22) has communication with a first group of flue-gas channels (17a) which include those flue gas channels that are located in the near vicinity of said half circumference and which, in turn, are connected solely to a flue-gas turning chamber (14) on the burner side delimited by the outer wall (25) and the first combustion-chamber wall (18). The flue-gas turning chamber (14) is connected with the combustion chamber (20) by means of a gap (23) located in the vicinity of the burner-accommodating opening, and is also connected to a second group of flue-gas channels (17b) including the remainder of the flue gas channels, which are connected to a flue-gas pipe (28) which extends through the other outer wall (27), the pipe (28) communicating with the surroundings. <IMAGE>
Patent DE-69318902-T2 (DE)
Inventor: CAUFIELD CRAIG EUGENE
IPC: A61K31/445
Filed: 1993-08-06
Granted: 1999-02-25
Abstract: This invention provides a method of treating ulcerative colitis, Crohn's disease or ulcerative proctitis in a mammal in need thereof which comprises administering an effective amount of rapamycin, alone or in combination with cyclosporin A.
Patent DE-69327760-T2 (DE)
Inventor: SMITH SUZANNE VIRGINIA
IPC: C07C237/06
Filed: 1993-07-29
Granted: 2000-09-07
Abstract: A physiologically acceptable, radiolabelled compound of general formula (I) <CHEM>  where     k is an integer from 2 to 5   l is an integer from 1 to 5 X and Y are independently selected from phenyl, naphthyl, pyridine or quinoline radical, each having at position 2 one of -OH, -SH, -NH2 or -COOH and each of X and Y can be optionally substituted by one or more amino, halogen, hydroxy, mercapto, nitro, cyano, thiocyano, alkyl, alkoxy, halogenoalkyl, acyl, acylamino, acyloxy, carboxyl, alkoxycarbonyl, carbamoyl, pyridoylamino, N-carboxyalkyl-carbamoyl, sulpho, sulphamoyl, mono- or dialkylated or phenylated sulphamoyl which can also carry one or more substituents R<1>, alkylsulphonyl, alkoxysulphonyl, or by an optionally hydroxy-containing phenylsulphonyl or phenoxysulphonyl; where R<1> is as defined for X and Y; or pharmaceutically acceptable salts thereof for use in diagnosis or therapy.
Patent DE-69408800-T2 (DE)
Inventor: DECKERT FRANCIS
IPC: H01H71/52
Filed: 1994-12-02
Granted: 1998-10-22
Abstract: It includes fixed contact means (51), moving contact means (5, 5a, 50) capable of taking up a working position and a rest position, an electrical fault detector (1, 2, 3, 14) reacting to a fault by setting itself to active position, and control means (6, 7, 20) for switching the said movable contact means in one or the other of the said positions. Releasable linking means (7b, 11, 11a) can selectively take up an engaged position, in which case they form a mechanical link between the said control means (6, 7, 20) and the said movable contact means (5, 5a, 50), and a tripped position, in which case the said movable contact means are mechanically decoupled from the said control means. These linking means in engaged position react to the setting of the fault detector (1 to 3, 14) in active position by putting themselves in tripped position. <IMAGE>
Patent DE-69409260-T2 (DE)
Inventor: GRAY STEPHEN
IPC: B65D47/14
Filed: 1994-12-28
Granted: 1998-09-24
Abstract: A thermoplastic closure for a fluid container which has a flexible needle-like dispensing extension continuous with and extending from the base and ending at a tip wherein the extension has an internal cylindrical cavity with an interior aperture positioned within the base and an exterior aperture positioned at the tip. The flexible, needle-like extension facilitates ease in refilling reservoirs such as ink-jet cartridges and facilitates control over the rate of flow of the ink from the container into the reservoir.
Patent DE-69410291-T2 (DE)
Inventor: STANLEY CHRISTOPHER
IPC: C07K14/00
Filed: 1994-11-30
Granted: 1998-10-29
Abstract: A selected region of a nucleic acid is protected from attach by nuclease by completing to the nucleic acid a nucleic acid analogue of the PNA type. The surviving sequence may be detected in an assay, optionally after amplification. A PCR reaction may be sterilized and its product assayed by protecting a characterizing region of the product by PNA hybridization followed by nuclease degradation of unprotected nucleic acid.
Patent DE-69410509-T2 (DE)
Inventor: WILLIAMS PAUL HOWARD
IPC: A61K31/535
Filed: 1994-02-23
Granted: 1999-01-28
Abstract: Compounds corresponding to the general formula (I) <IMAGE> in which Y represents a hydrogen, fluorine or chlorine atom or a methyl or methoxy group, R1 represents either a phenyl group substituted by a fluorine atom or by a group chosen from the methyl, methoxy, trifluoromethyl and phenyl groups or represents a 2-thienyl group, R2 represents a methyl group, R3 represents either a (C1-C4)alkyl group or represents a phenyl(C1-C2)alkyl group optionally substituted on the ring by 2 to 3 methoxy groups, or represents a 2-(pyrid-2-yl)ethyl group, or else R2 and R3 form, with the nitrogen, either a 4-phenyl(piperid-1-yl)group or a 4-phenylmethyl(piperid-1-yl) group or a 1,2,3,4-tetrahydroisoquinol-2-yl group or a 6-methoxy-1,2,3,4-tetrahydroisoquinol-2-yl group or a 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl group or a 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl group or a 2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl group or a 7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl group and X represents either a carbonyl group or a sulphonyl group. Application in therapeutics.
Patent DE-69418923-T2 (DE)
Inventor: PASZEK LEON E
IPC: C11D3/00
Filed: 1994-03-23
Granted: 1999-10-21
Abstract: Formulation comprises: (a) 20-50 pts. wt. powdered cellulose; (b) 10-25 pts. wt. borax; (c) 0-10 pts. wt. hydrated amorphous silica; (d) 0-10.0 pts. wt. of one or more anionic surfactants; (e) 0.5-10.0 pts. wt. of an organic solvent; (f) 30.0-60 pts. wt. water; and (g) 0-10.0 pts. wt. of a zeolite, provided that at least one of the silicas or the zeolite is always present in the formulation. The surfactant is pref. selected from: 12-18C fatty alcohol sulphates contg. 16-20C in the alcohol portion; alkylbenzene sulphonates contg. 9-15C alkyl gps.; alkali alkyl sulphonates; and mixts. of these. The organic solvent is pref selected from: alcohols, glycols, glycol ethers and mixts. of these. The zeolite is pref. sodium aluminium silicate.
Patent DE-69431002-T2 (DE)
Inventor: KASHUBA GLEN A
IPC: A61F2/36
Filed: 1994-05-10
Granted: 2003-05-08
Abstract: An apparatus (90) for reaming the medial portion medullary canal in the calcar region (62) of a long bone. The apparatus includes:     a flexible shaft (92) having a first end and a second end; a smooth distal head (91) fixedly attached to said first end of said flexible shaft; a reamer (93) fixedly attached to said second end of said flexible shaft; a solid shaft (94) having a first end fixedly attached to said reamer (93) and a second end having a connector (96) for connection to a rotary power transmission source, and means (95) disposed proximally from said cylindrical reamer and spaced between said first and second ends of said solid shaft (94) for guiding the apparatus within a hollow member (73) of a template (80).   <IMAGE>
Patent DE-69434782-T2 (DE)
Inventor: ISHIZAKA KIMISHIGE
IPC: C12N15/00
Filed: 1994-05-13
Granted: 2007-06-14
Abstract: Polypeptides, polynucleotides, fragments thereof, and monoclonal antibodies thereto are provided for antigen-specific and antigen-non-specific glycosylation inhibiting factor and a method for recombinant production of biologically active polypeptides from a structural gene encoding the polypeptide.
Patent DE-69516282-T2 (DE)
Inventor: LENBERG LARS
IPC: G05D16/10
Filed: 1995-06-16
Granted: 2000-11-30
Abstract: A device (100) for pressure and flow control of a cooling or heating system (101-105) comprises a valve device (1), which has a house (2) with one connection piece (3) for incoming supply medium, one connection piece (4) for outgoing supply medium, a continuously open passage (24) connecting said connection pieces (3, 4), one connection piece (5) for incoming return medium and one connection piece (6) for outgoing return medium, a control valve (7), upon which a compression spring (16) acts, acting from the outlet side (6) of the return medium aginst its inlet side (5). In accordance with the invention the control valve (7) is hollow with a piston spindle (38), which at one of its ends supports a piston part (14), which constitutes a part of the control valve, and at its other end, which is exposed to said passage (24), and centrally a membrane device (9, 44), which comprises a control room (60), which via cavities (58, 59, 61) in the piston part (14) and in the piston spindle (38) communicates with the return inlet side.
Patent DE-69517915-T2 (DE)
Inventor: AULANKO ESKO
IPC: B66B7/06
Filed: 1995-10-27
Granted: 2000-11-09
Abstract: The traction sheave elevator comprises an elevator car (1) moving along elevator guide rails (10), a counterweight (2) moving along counterweight guide rails (11), a set of hoisting ropes (3) on which the elevator car and the counterweight are suspended, and a drive machine unit (6) comprising a traction sheave (7) driven by the drive machine and engaging the hoisting ropes (3). The drive machine unit (6) of the elevator is placed in the top part of the elevator shaft. The drive machine unit (6) is mounted on the upper end of one or more guide rails (10,11,11a). <IMAGE>
Patent DE-69524344-T2 (DE)
Inventor: CLAUSSNER ANDRE
IPC: C07D491/107
Filed: 1995-09-28
Granted: 2002-08-22
Abstract: Imidazolidines of formula (I) in racemic, enantiomeric and diasteroisomeric forms, and their salts are new. In (I) ring is e.g. satd. heterocycle of 4-7 members contg. either O, N, S (opt. oxidised), and opt. substd. by a group selected from R3; Ar is e.g. aryl (opt. substd. by halo, CN, NO2, CF3, CF3O, OH, COOH or salified, esterified, or amidified COOH) or a gp. (ii) in which N is opt. oxidised and R1 and R2 are H or (substd.) alkyl, or form with N atom e.g. 5, 6 or 7 membered monocyclic ring opt. contg. other heteroatoms (O, N, S) and opt. substd. etc.; X is O or S; Y is O, S or NH; R3 is H, aryl, alkyl, alkenyl, alkynyl, opt. interrupted by one or more O, N, or S (opt. oxidised) atoms, and opt. substd.
Patent DE-69535195-T2 (DE)
Inventor: MULLER GEORGE
IPC: A61K31/40
Filed: 1995-11-20
Granted: 2007-07-12
Abstract: Novel imides are inhibitors of tumor necrosis factor alpha and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is (R)-2-Phthalimido-3-(3',4'-dimethoxyphenyl)propane
Patent DE-69604051-T2 (DE)
Inventor: HENEINE WALID
IPC: C12Q1/70
Filed: 1996-01-26
Granted: 1999-12-16
Abstract: The present invention provides a method for detecting the presence of a retrovirus in a biological sample comprising the steps of: a) contacting the biological sample with an RNA template and a complementary DNA primer under conditions whereby the RNA template and the DNA primer will anneal and a DNA strand will be synthesized as an extension from the DNA primer if reverse transcriptase is present in the sample; b) amplifying the synthesized DNA; and c) detecting the amplification of the synthesized DNA, the amplification of the synthesized DNA indicating the presence of reverse transcriptase in the biological sample, thus indicating the presence of a retrovirus in the biological sample.
Patent DE-69604872-T2 (DE)
Inventor: GAZZA CARLO
IPC: A61D1/02
Filed: 1996-07-11
Granted: 2000-02-17
Abstract: A syringe for the intramammary administration of veterinary pharmacological compositions, in particular for the treatment of bovine mastitis. The syringe comprises a container body (1), a cannula (3) extending axially from one of its ends, a removable shutter (4) surrounding the initial part of the cannula (3), and a protective cap (6) covering both the cannula (3) and the shutter (4). During use, when the cap (6) is removed, only the end part of the cannula (3) is freed so as to allow insertion into the initial section of the teat; when the shutter (4) is also removed, the entire cannula (3) is freed so as to allow insertion as far as the teat cistern. <IMAGE>
Patent DE-69604914-T2 (DE)
Inventor: FJELLDAL ERLING
IPC: C05F7/00
Filed: 1996-04-18
Granted: 2000-04-20
Abstract: PCT No. PCT/IB96/00346 Sec. 371 Date Dec. 31, 1997 Sec. 102(e) Date Dec. 31, 1997 PCT Filed Apr. 18, 1996 PCT Pub. No. WO96/33961 PCT Pub. Date Oct. 31, 1996A process for producing a fertilizer from an organic waste material is described which comprises treating a waste, having a water content of no more than 90% by weight and which has been alkalinized, with nitrogen dioxide or a precursor thereof in sufficient amount to reduce the pH by at least 2.0 pH units. The process produces an organic fertilizer in which the percentage by weight of nitrogen in the form of oxides of nitrogen is higher than percentage by weight of nitrogen in the form of ammonium ion.
Patent DE-69606475-T2 (DE)
Inventor: BOFFITO CLAUDIO
IPC: F17C3/08
Filed: 1996-08-02
Granted: 2000-07-20
Abstract: A combination of getter materials particularly suitable to maintain vacuum in devices which cannot be heated at temperatures higher than about 2000C comprises: a) a mixture MO/Pd between an oxide of a transition metal MO chosen among cobalt oxide, copper oxide or their combinations and metallic palladium, wherein the latter is present up to about 2% by weight; and b) a moisture sorbing material. In particular applications it is possible to add to this combination also a barium- and lithium-based alloy, preferably BaLi4. Getter devices for containing such a combination are also described. <IMAGE>
Patent DE-69607647-T2 (DE)
Inventor: COLLOMBIN ANDRE-MARCEL
IPC: B29C49/06
Filed: 1996-09-23
Granted: 2000-11-23
Abstract: PCT No. PCT/IB96/00979 Sec. 371 Date Apr. 14, 1998 Sec. 102(e) Date Apr. 14, 1998 PCT Filed Sep. 23, 1996 PCT Pub. No. WO97/20678 PCT Pub. Date Jun. 12, 1997The heating device for a machine for transforming plastic materials, comprises a heating body (39) disposed between two parallel rows (41, 42) of preforms (14). It is provided with at least two heating tubes (40) having bidirectional heating blades (54). These latter are inclined at an angle ( alpha ) such that a first of their faces emits heating radiation (55) in the direction of the adjacent row of preforms and such that the second surface emits its heating radiation (56) substantially in the direction of the free space between the two opposite rows of heating tubes toward the farthest row of preforms. Reflectors (60) are moreover arranged so as to reflect the heating radiation in a horizontal plane toward the preforms (14). The device thus permits obtaining very high energy efficiency whilst avoiding a harmful elevation of the temperature of the machine into which it is integrated.
Patent DE-69609162-T2 (DE)
Inventor: MOBERG GERTH
IPC: F41J13/00
Filed: 1996-10-14
Granted: 2001-03-01
Abstract: PCT No. PCT/SE96/01301 Sec. 371 Date Jun. 13, 1997 Sec. 102(e) Date Jun. 13, 1997 PCT Filed Oct. 14, 1996 PCT Pub. No. WO97/14929 PCT Pub. Date Apr. 24, 1997A device for limiting, controlling and disposing leached lead. Shooting is made through an elastic layer, providing a watertight cover which closes after the passage of a projectile, the latter subsequently being arrested in a projectile-arresting material kept in an enclosed space created by a watertight layer. Precepition water penetrating the minimal projection penetrating holes is drained via the arresting material, along the inclined insides of the watertight layer, down to a lowermost point where the water is collected by a drainage line. The drainage water is discharged through a pipe to a closed reservoir or to a filter.
Patent DE-69613842-T2 (DE)
Inventor: SCHEPER MICHAEL
IPC: C11D3/26
Filed: 1996-05-17
Granted: 2002-04-04
Abstract: Automatic dishwashing detergent compositions comprising certain cobalt catalysts are provided. More specifically, the invention relates to automatic dishwashing detergents which provide enhanced cleaning/bleaching benefits (especially tea stain removal) through the selection of cobalt bleach catalyst having the formula:[Co(NH3)n(M)m(B)b]Tywherein cobalt is in the +3 oxidation state; n is 4 or 5 (preferably 5); M is one or more ligands coordinated to the cobalt by one site; m is 0, 1 or 2 (preferably 1); B is a ligand coordinated to the cobalt by two sites; b is 0 or 1 (preferably 0), and when b=0, then m+n=6, and when b=l, then m=0 and n=4; and T is one or more appropriately selected counteranions present in a number y, where y is an integer to obtain a charge-balanced salt (preferably y is 1 to 3; most preferably 2 when T is a -1 charged anion); and wherein further said catalyst has a base hydrolysis rate constant of less than 0.23 M-1 s-1 (25 DEG  C.). Preferred automatic dishwashing compositions comprise amylase and/or protease enzymes. Included are methods for washing tableware in domestic automatic dishwashing appliances using the cobalt catalysts.
Patent DE-69615814-T2 (DE)
Inventor: MIZUKAMI TAMIO
IPC: C07D207/34
Filed: 1996-09-11
Granted: 2002-06-06
Abstract: This invention relates to UCH15 compounds of the formula (I): <CHEM> wherein R<1> represents a hydrogen atom or a hydroxyl group.C
Patent DE-69616836-T2 (DE)
Inventor: ASTROEM ANETTE
IPC: A47D11/02
Filed: 1996-08-09
Granted: 2002-08-22
Abstract: PCT No. PCT/SE96/00999 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Aug. 9, 1996 PCT Pub. No. WO97/06714 PCT Pub. Date Feb. 27, 1997A chair that can be adapted for use as a child's chair has a bottom part (1) which carries a seat (2) and a back rest (3). The seat (2) is comprised of a first fixed part (4) and a second part (5) which is hinged to the fixed part such as to enable the second part to be raised from a normal state of use of the chair in which its seating surface (6) is located forwardly of and in the plane of the seating surface (7) of the first part (4), to a position in which the seating surface (6) of the first part rests on the seating surface (7) of the first part (4). The underside of the second part (4) includes a further seating surface (9) which when the second part is raised is located above and spaced from the seating surface (6) of the second chair-part (5).
Patent DE-69627936-T2 (DE)
Inventor: VAN GOOR ALBERT
IPC: H01S3/104
Filed: 1996-02-01
Granted: 2004-05-19
Abstract: PCT No. PCT/NL96/00050 Sec. 371 Date Sep. 23, 1996 Sec. 102(e) Date Sep. 23, 1996 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/24181 PCT Pub. Date Aug. 8, 1996Described are a method for generating a laser beam and a laser device for practising the method. In a first step gas is ionised by means of X-rays. In a second step the electron density is increased by means of a pre-discharge. In a third step the main discharge takes place. Between the second and third steps, an electron redistribution occurs. According to the invention, the electron redistribution rate and/or the time delay between the pre-discharge and the main discharge are adjustable and controllable in relation to each other, for achieving a particular desired beam profile, such as a uniform profile. Because that delay is preferably set by varying one or more process parameters, an improtant advantage is achieved in that it is possible with one and the same laser device to modify the beam profile in a simple and flexible manner even during the operation of the laser device.
Patent DE-69637389-T2 (DE)
Inventor: KUTYAVIN IGOR V
IPC: C12Q1/68
Filed: 1996-04-03
Granted: 2008-12-18
Abstract: Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI3), and an oligonucleotide form unusually stable hybrids with complementary target sequences, in which the tethered CDPI3 group resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to their unusually high binding affinity, conjugates as short as 8-mers can be used as amplification primers with high specificity and efficiency. MGB conjugation also increases the discriminatory power of short oligonucleotides, providing enhanced detection of nucleotide sequence mismatches by short oligonucleotides. The MGB-conjugated probes and primers described herein facilitate various analytic and diagnostic procedures, such as amplification reactions, PCR, detection of single-nucleotide polymorphisms, gene hunting, differential display, fluorescence energy transfer, hydrolyzable probe assays and others; by allowing the use of shorter oligonucleotides, which have higher specificity and better discriminatory power.
Patent DE-69714844-T2 (DE)
Inventor: CHOUDHERY RIAZ AHMAD
IPC: C08J3/03
Filed: 1997-05-26
Granted: 2003-04-30
Abstract: A continuous process is disclosed for preparing a reactive particulate dispersion in a liquid carrier. The process comprises mixing together as a melt a resin and a crosslinker under extrusion condition at a temperature and for a time such that substantial crosslinker potential is retained between the resin and the crosslinker and thereafter dispersing the mixture whilst still molten into the liquid carrier and allowing the molten dispersed mixture to solidify to form particles.