baber/WOPTO huggingface dataset:
Patent RU-2736511-C1 (RU)
Inventor: Karlov Dmitry Sergeevich
IPC: C07C211/48
Filed: 2020-01-24
Granted: 2020-11-17
Abstract: FIELD: chemistry. 
     SUBSTANCE: invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, which have NMDA receptor antagonist activity. In formula IX, -H, a halogen atom or -CH 3 ; Z is -OR' or -NR'R''; linker L denotes a group -(C 0-2 alkylene)-Y-(C 0-2 alkylene)-, where C 0 alkylene refers to a single bond and where Y represents a group -O- or -NR'-; R1 denotes -H, -OR', -NR'R'' or -NR'-SO 2 -(C 1-6 -alkyl); R2 is -H, -OR' or -NR'R''; R in each case means H; R' and R'' in each case independently represent groups selected from H and C 1-6 -alkyl; and m is 3, with the proviso that X, R1 and R2 are not all simultaneously H, and with the proviso that when one group of R1 and R2 is -NH 2  and the other is -H, X is -H, and L is -CH 2 -O-, then Z is not -OH. Invention also relates to a pharmaceutical composition for inhibiting NMDA receptors containing a pharmacologically effective amount of one or more compounds of formula I or their pharmaceutically acceptable salts and one or more pharmaceutically acceptable adjuvants. In formula IX, -H, a halogen atom or -CH 3 ; Z is -OR' or -NR'R''; linker L denotes a group -(C 0-2 alkylene)-Y-(C 0-2 alkylene)-, where C 0 -alkylene denotes a simple bond and where Y denotes a -O- or -NR'- group; R1 denotes -H, -OR', -NR'R'' or -NR'-SO 2 -(C 1-6 -alkyl); R2 is -H, -OR' or -NR'R''; R in each case means H; R' and R'' in each case independently represent groups selected from H and C 1-6 -alkyl; and m is equal to 3. Also described is a method of treating a disorder or disease accompanied by high activation of the NMDA receptor, comprising a step, wherein an effective amount of one or more compounds of formula I or pharmaceutically acceptable salts or a pharmaceutical composition thereof is administered to a patient in need thereof. In formula IX, -H, a halogen atom or -CH 3 ; Z is -OR' or -NR'R''; linker L denotes a group - (C 0-2  alkylene)-Y-(C 0-2  alkylene)-, where C 0  alkylene refers to a single bond and where Y represents a group -O- or -NR'-; R1 denotes -H, -OR', -NR'R'' or -NR'-SO 2 -(C 1-6 -alkyl); R2 is -H, -OR' or -NR'R'' ; R in each case means H; R' and R'' in each case independently represent groups selected from H and C 1-6  -alkyl; and m is equal to 3. Also disclosed is use of compounds of formula I as inhibitors of NMDA-receptors. In formula IX, -H, a halogen atom or -CH 3 ; Z is -OR' or -NR'R''; linker L denotes a group -(C 0-2 alkylene)-Y-(C 0-2 alkylene)-, where C 0 -alkylene denotes a simple bond, and where Y denotes a -O- or -NR'-group; R1 denotes -H, -OR', -NR'R'' or -NR'-SO 2 -(C 1-6 -alkyl); R2 is -H, -OR' or -NR'R''; R in each case means H; R' and R'' in each case independently represent groups selected from H and C 1-6  -alkyl; and m equals 3. 
     
       
     
     EFFECT: disclosed are biphenyl derivatives having biological activity, pharmaceutical compositions and methods of treatment based on said compounds and use thereof. 
     32 cl, 3 tbl, 4 ex, 2 dwg
Patent RU-2742484-C1 (RU)
Title: C shuangzuocaotong crystalline form, method for production thereof and use thereof
Inventor: CHZHAO DE
IPC: A01P13/00
Filed: 2017-07-15
Granted: 2021-02-08
Abstract: FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and specifically to crystalline form C shuangzuocaotong, characterized in that crystalline form C has an X-ray powder diffraction pattern having characteristic absorption peaks at following positions 2θ: 10.159, 10.658, 13.318, 14.579, 16.096, 18.061, 19.322, 19.68, 20.04, 20.659, 21.281, 23, 24.16, 24.619, 26.101, 26.74, 30.359, 31.018, 32.378, 35.398 and 38.26 degrees, where 2θ has error interval within ±0.2°; where shuangzuocaotong is compound of 4-[2-methenesulphonyl-4-trifluoromethylbenzoyl]-1,3-dimethyl-1H-pyrazol-5-yl ester of 1,3-dimethyl-1H-pyrazole-4-carboxylic acid. Invention also relates to a method of producing crystalline form C, an herbicidal composition based thereon and use of crystalline form C or an herbicidal composition.EFFECT: technical result: obtaining crystalline form C 4-[2-methenesulphonyl-4-trifluoromethylbenzoyl]-1,3-dimethyl-1H-pyrazol-5-yl ester of 1,3-dimethyl-1H-pyrazole-4-carboxylic acids, having good stability and high efficiency for control of broadleaf weeds and gramineous weeds in wheat.9 cl, 2 tbl, 2 ex, 2 dwg
Patent RU-2742736-C1 (RU)
Inventor: NIKITIN VLADIMIR NIKOLAEVICH
IPC: A61F9/007
Filed: 2020-03-10
Granted: 2021-02-10
Abstract: Изобретение относится к области медицины, а именно к офтальмологии. Для репозиции дислоцированного комплекса «ИОЛ-капсульный мешок» формируют лимбальный парацентез и склеральный прокол. Предварительно в инъекционную иглу, совмещенную с полой рукояткой, проводят полипропиленовую нить, формируя с колющего конца петлю, иглу сгибают под углом, срезом иглы вверх. В 2,5 мм от лимба в проекции гаптического элемента проводят сквозной прокол склеры и цилиарного тела инъекционной иглой, и после центрирования комплекса «ИОЛ-капсульный мешок», находящейся под ним, капсульный мешок перфорируют в проекции зрачка, в месте оптико-гаптического перехода с одной стороны гаптического элемента. Первую петлю выводят в парацентез, после этого иглу подводят под гаптический элемент с другой его стороны, и после перфорации капсульного мешка в проекции зрачка вторую петлю выводят из передней камеры в тот же парацентез. После извлечения иглы из глаза первую и вторую петли рассекают. Дупликатурную часть нити извлекают, а оставшиеся концы нити соединяют между собой узлами с формированием третьей петли, которую погружают в переднюю камеру, а затем через зрачок в заднюю камеру, и фиксируют на поверхности комплекса «ИОЛ-капсульный мешок». Далее те же действия осуществляют со вторым гаптическим элементом ИОЛ, используя тот же парацентез. После чего комплекс «ИОЛ-капсульный мешок» фиксируют к склере, обеспечивая погружение сформированного узлового шва в пространство между эписклерой и теноновой оболочкой. Способ снижает инвазивность репозиции дислоцированного комплекса «ИОЛ-капсульный мешок», повышает эффективность репозиции, уменьшает риск травматизации тканей глаза. 4 ил., 2 пр.
Patent RU-2742717-C1 (RU)
Inventor: AXNAS JOHAN
IPC: H04W74/08
Filed: 2018-09-04
Granted: 2021-02-10
Abstract: FIELD: wireless communications. 
     SUBSTANCE: invention relates to random access procedures used in wireless communications, and more specifically to NR-RACH configurations over time. The method comprises determining whether to restrict transmission of the random-access preamble during at least a portion of the set of synchronization signaling (SS) bursts. The set of SS packets contains at least one SS block indicated as being transmitted. In some embodiments, the method / wireless device / computer program code further comprises transmitting the random-access preamble during a time when the random-access preamble is not restricted. 
     EFFECT: technical result is to simplify the reception of TRP NR-RACH in the absence of full duplex and / or full digital beamforming due to the fact that the locations of the NR-RACH in time can be aligned between numerologies. 
     37 cl, 12 dwg
Patent RU-2757182-C1 (RU)
Title: Portable individual respirator and its use
Inventor: VIRR ALEXANDER
IPC: A62B18/02
Filed: 2018-09-13
Granted: 2021-10-11
Abstract: FIELD: medicine.SUBSTANCE: respiratory system contains a respirator with an air filter, a flow generator with a sensor-less DC engine, a mask, a processor, a sensor, a power source and a wireless transceiver. The respirator filters the air, increases the air pressure, supplies air to the mask under pressure higher than the ambient pressure, collects data using the sensor about the operation of the respirator and transmits data. An intermediate electronic device is separate from the respirator, and is located at a distance from it, and is made with the possibility to receive transmitted data, process data and generate at least one report concerning the respirator or a user of the respirator.EFFECT: obtaining portable individual respirator.45 cl, 7 dwg
Patent RU-2738118-C1 (RU)
Inventor: Tsareva Yana Olegovna
IPC: B82Y40/00
Filed: 2020-06-17
Granted: 2020-12-08
Abstract: FIELD: chemistry. 
     SUBSTANCE: invention relates to inorganic chemistry, specifically to a method of producing modified nanoparticles of gadolinium-doped magnetite. These nanoparticles can be used, for example, as double contrast agents for MRI diagnostics. Method of producing modified nanoparticles of magnetite doped with gadolinium involves mixing an aqueous solution containing a mixture of FeCl 2 ⋅4H 2 O and hydrate of gadolinium chloride, with an aqueous solution of sodium benzoate, adding acetonitrile to the obtained solution, stirring the mixture to form a precipitate, separating the formed precipitate from the supernatant, washing the residue with diethyl ether, drying the residue on air, mixing it with oleylamine, oleic acid and dibenzyl ether, heating the obtained mixture to 110 °C in atmosphere of inert gas with subsequent temperature increase to 310 °C, cooling mixture to room temperature in atmosphere of inert gas, adding alcohol, separation of particles, their redispersion in hexane and treatment of nanoparticles with an organic hydrophilic modifier. Gadolinium chloride hydrate is used GdCl 3 ⋅6H 2 O, metal chlorides are taken in molar ratio FeCl 2 ⋅4H 2 O:GdCl 3 ⋅6H 2 O = 2.5:1.2, mixture heating from 110 °C to 310 °C is carried at rate of 2°/min and the mixture is held at 310 °C for 30 minutes, and the organic hydrophilic modifier used is Pluronic F-127, which is a block copolymer of polyoxyethylene and polyoxypropylene. 
     EFFECT: technical result consists in increase of saturation magnetization in 1.70 times, relaxation factor r 1  in 1.04 times and relaxation factor r 2  in 1.37 times. 
     1 cl, 3 ex
Patent RU-2736742-C1 (RU)
Inventor: GABBASOV TAGIR MUDARISOVICH
IPC: E21B33/138
Filed: 2020-07-14
Granted: 2020-11-19
Abstract: FIELD: soil or rock drilling. 
     SUBSTANCE: invention relates to drilling of wells, namely to methods and devices for isolation of drilling fluid absorption zones in a well under construction. In particular, disclosed is a method of isolating an absorption zone in a well being constructed, comprising determining an absorption interval, a volume of the grouting mixture, assembly of device for insulation of absorption zone, filling with grouting mixture, device lowering to well to tamponing zone, well borehole shutoff above plugged interval, displacement of grouting mixture into absorption zone. At the well head, a device for insulation of the absorption zone from below upwards is assembled, which includes a guide shoe with flushing holes, closed with plastic conical plugs and a destructible diaphragm installed on it, tubular housing with centralizers in form of drilled pipe. Then the grouting mixture is poured into the tubular housing of the device; the upper branch pipe is connected to the self-packing packer and the centraliser installed on it and the bushing installed in the tubular case. After that, the upper branch is connected to the electromagnetic disconnector and the device is lowered into the well on the geophysical cable to the bottomhole, the speed and depth of descent are controlled. At that, the absorption zone of the device is shut off, and the self-sealing packer is placed at the level of the roof of the absorption zone, overlapping the annular space of the well. Device is disconnected from the electromagnetic disconnector and the electromagnetic disconnector is removed from the well on the geophysical cable. Assembly of the bottom of the drill string is assembled and lowered to the well on drill pipes to the level of liquid in the well; the entire interval of the well above the device for insulation of the absorption zone is filled with the drilling fluid by the drilling fluid. Self-sealing packer and the bung tube inside the device operate synchronously and isolate the absorption zone from the rest of the well. Assembly of the bottom of the drill string is lifted above the shoe of the conductor and the preventer of the well is closed. Cementing unit is connected to the pump manifold of the drilling rig and the flushing fluid is pumped into the well through the drilling pipes. Device diaphragm is broken, grooving mixture is to be forged from device in interval of absorption zone to obtain "stop" pressure. At that, the backfill mixture is squeezed into the formation, the preventer is opened, the well is left for process exposure for the time of waiting for hardening of cement. Then the hardened cement is drilled together with the device for insulation of the absorption zone using the guide shaft produced inside the tubular body of the device at the grouting mixture marketing, and deepening wells in standard mode is continued. 
     EFFECT: high success of isolating absorption zones in a drilled well and reducing time and costs for carrying out said operations. 
     3 cl, 1 dwg
Patent RU-2749294-C1 (RU)
Title: Method for treatment of acute ischemia of limbs
Inventor: Magamedov Islam Dzhabrailovich
IPC: A61P9/10
Filed: 2020-06-30
Granted: 2021-06-08
Abstract: FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to vascular surgery, and can be used in the treatment of patients with acute thromboembologic ischemia of the lower extremities. The method includes the introduction of a vasoactive drug, which is used as dexamethasone, which is injected intravenously at a dose of 8 mg in 200 ml of isotonic sodium chloride solution after reconstructive surgery, with a course of 4 to 6 days.EFFECT: use of the invention makes it possible to improve the results of postoperative treatment of patients with acute ischemia of the lower extremities, to reduce mortality, the frequency of complications of both infectious and inflammatory genesis, to reduce the number of amputations, to shorten the duration of treatment.1 cl, 3 ex
Patent RU-2747077-C1 (RU)
Inventor: Kuzmin Vladislav Sergeevich
IPC: G01R27/04
Filed: 2020-10-14
Granted: 2021-04-26
Abstract: FIELD: railway automation; teleautomatics. 
     SUBSTANCE: invention relates to the field of railway automation and teleautomatics, in particular to means of diagnostics of rail chains and means of measuring the resistance of a train shunt. The system for monitoring the false freeness of the rail chain and the resistance of the train shunt of biaxial moving units contains two rails, equipment for the supply and relay ends of the rail chain. On the rails, there is a biaxial mobile unit. The mobile unit is equipped with the first, second, third and fourth current sensors, a coordinate determination unit, an information processing unit, an indication unit, a wireless information transmission channel consisting of a transmitter, a communication line and a receiver, a measurement unit, a rail chain analyzer, a memory unit and an automated workplace.   
     EFFECT: determination of the cause of false freeness and fixing the resistance of the train shunt and a separate wheel pair, taking into account the wheel-rail transition resistances. 
     1 cl, 1 dwg
Patent RU-2751251-C1 (RU)
Title: Double-layer confectionery product
Inventor: Ivanov Valerii Nikolaevich
IPC: A23G3/36
Filed: 2020-11-21
Granted: 2021-07-12
Abstract: FIELD: food industry.SUBSTANCE: invention relates to the food industry, in particular to confectionery sector, it can be used in the production of double-layer candies. A double-layer confectionery product is proposed, which is a formed body consisting of two layers of candy mass, each of which is a milk mass containing a milk component, a fat component, a sugar-containing component, molasses, food salt. The candy mass additionally contains sorbitol, invert syrup, glycerin, pectin solution, monoglycerides, an antioxidant “Nova Sol Cof”, and condensed milk with sugar as a milk component, confectionery fat as a fat component, and 80% sugar syrup as a sugar-containing component, with the following ratio of the initial components in wt.%: condensed milk with sugar is 29.12 – 30.08; molasses is 11.42 – 12.87; confectionery fat is 10.05 – 10.87; sorbitol is 6.76 – 6.98; invert syrup is 6.75 – 6.92; glycerin is 2.48 – 2.86; pectin solution is 0.84 – 0.91; food salt is 0.54; monoglycerides are 0.15 – 0.18; antioxidant “Nova Sol Cof” is 0.03 – 0.04; sugar syrup is the rest. The candy mass for making one layer of the body is made by mixing the milk mass with a solution of food coloring Titanium dioxide and Toffee flavor with the following ratio of the initial components in wt.%: a solution of food coloring titanium dioxide is 1.16 – 1.19; Toffee flavor is 0.1; the milk mass is the rest. The candy mass for making the second layer of the body is made by mixing the milk mass with caramelized sugar, Mocha paste and Coffee flavor with the following ratio of the initial components in wt.%: caramelized sugar is 0.96 – 0.99; Mocha paste is 0.43 – 0.52; coffee flavor is 0.15 – 0.17; milk mass is the rest.EFFECT: invention consists in improving consumer properties due to the stability of the bodies of products with visually non-mixing layers of candy mass, without delamination of their structure and shape during the entire storage life, in expanding the arsenal of products for this purpose, as well as in improving the organoleptic properties of double-layer products by giving a new taste and attractive appearance.1 cl, 4 tbl, 2 ex
Patent RU-2755860-C1 (RU)
Title: Solar collector
Inventor: BABAEV BABA DZHABRAILOVICH
IPC: F24S10/80
Filed: 2020-11-30
Granted: 2021-09-22
Abstract: FIELD: solar engineeringSUBSTANCE: invention relates to the field of solar engineering, namely to low-temperature solar collectors, and can be used in heating and air conditioning systems in premises. The solar collector contains a closed shell consisting of a round central surface and a side cylindrical surface connected to it, made of a transparent single-layer or multi-layer material, the base is made of a heat-insulating material, a metal sponge is located inside the closed shell, a pipe for removing hot coolant is located in the center of the round central surface. The heated coolant, such as air, is fed into a closed shell of the solar collector filled with a metal sponge. The sun rays, penetrating through the transparent central and side surfaces, are absorbed by a metal sponge made of thin metal threads, and heat the coolant (air) in the channels of the sponge. The heated coolant flows through channels in the metal sponge into a pipe located in the center and is then supplied to consumers.EFFECT: solar collector is characterized by simplicity of design, economy, has a greater absorption capacity of sunlight in a metal sponge, regardless of the position of the Sun, reduces energy consumption for pumps and material consumption.1 cl, 3 dwg
Patent RU-2762265-C1 (RU)
Title: Method for evaluating transport of negatively charged drugs on experimental model of hek293 cell line
Inventor: Evteev Vladimir Aleksandrovich
IPC: C12Q1/68
Filed: 2020-12-08
Granted: 2021-12-17
Abstract: FIELD: biotechnology; pharmacology; molecular biology.SUBSTANCE: it can be used in the examination of drugs having a renal excretion pathway, as well as at the preclinical stage in the development of new drugs, the invention makes it possible to evaluate the transport of negatively charged drugs - substrates of OAT1 transporter by comparing expression levels of SLC22A6 gene of HEK293-OAT1 cell line by reverse transcription polymerase chain reaction.EFFECT: obtaining a method for evaluating transport of negatively charged drugs on experimental model of HEK293 cell line.1 cl, 9 dwg, 1 tbl, 4 ex
Patent RU-2753455-C1 (RU)
Title: Method for differential diagnosis of liver steatosis and non-alcoholic steatohepatitis in men
Inventor: Demianova Elena Valerevna
IPC: G01N33/92
Filed: 2020-12-11
Granted: 2021-08-16
Abstract: FIELD: medicine.SUBSTANCE: invention relates to medicine and deals with a method for the differential diagnosis of liver steatosis and non-alcoholic steatohepatitis in men. The essence of the method is that the ratio of the concentration of 3-hydroxybutyric and 3-methyl-2-oxovaleric acids determined by chromatographic method in a patient's venous blood sample is determined. When the ratio of the concentration of 3-hydroxybutyric acid to the concentration of 3-methyl-2-oxovaleric acid is 19/1 or more, liver steatosis is diagnosed, with a ratio of 13/1 or less, NASH is diagnosed.EFFECT: method can be used for non-invasive determination of liver steatosis and non-alcoholic steatohepatitis in male patients with non-alcoholic fatty liver disease.1 cl, 5 dwg, 3 tbl, 2 ex
Patent RU-2754927-C1 (RU)
Title: Method for immobilizing microorganisms on montmorillonite clays
Inventor: Shajdorova Galina Mikhajlovna
IPC: C12N11/00
Filed: 2020-12-28
Granted: 2021-09-08
Abstract: FIELD: biotechnology.SUBSTANCE: invention relates to biotechnology and is a method for immobilizing microorganisms on montmorillonite clays. The method includes mixing pre-enriched and activated 10% hydrochloric acid montmorillonite clay with biological material in the form of biomass of microorganisms Lysobacter sp. Wherein, after activation, montmorillonite clay is washed with purified distilled water to a neutral medium, dried at a temperature of no more than 105°C and ground in a ball mill to a particle size of no more than 10 mcm; and biological material in the form of biomass of microorganisms Lysobacter sp. pre-fill with 0.05 M tris-hydrochloride buffer solution with pH 7.5 and mix, wherein, with stirring, the mixture is gradually heated to 45°C for 5 minutes, then cooled to room temperature and centrifuged, after which the supernatant is decanted and to the remainder of the treated biomass in the form of L-form Lysobacter sp. with constant mechanical stirring, the crushed clay is gradually added in the ratio of the carrier : biomass equal to 1:(2-4) at a temperature of 25°C; the mixture is thoroughly mixed for at least 40 minutes and then freeze-dried at a temperature of minus 40-45°C for 24 hours to a level of 3-7% moisture content of the composition.EFFECT: invention allows extending the shelf life of bacterial cells of Lysobacter sp. on a carrier made of montmorillonite clay, with the possibility of ensuring the restoration of their activity when applied to the wound surface.2 cl, 1 tbl, 5 ex
Patent RU-2766225-C1 (RU)
Title: Method for making forged pieces from austenitic steels
Inventor: OLENIN MIKHAIL IVANOVICH
IPC: B21K21/00
Filed: 2021-05-24
Granted: 2022-02-10
Abstract: FIELD: metallurgy.SUBSTANCE: invention relates to ferrous metallurgy and can be used in production of thick-walled forgings from steels of austenitic class used for production of articles of thermal and nuclear power engineering. Molten ingot after complete heating is subjected to homogenisation at temperature of 1,190±20°C with holding for 16 hours. Ingot is subjected to upsetting at temperature of 1,190±20°C. Then, forging operations are performed at temperature not exceeding 1,090±20°C, with cooling of forgings after forging process in water. Forgings are austenised at temperature of 1,025±20°C with holding of 1.2–1.3 min/mm of section with subsequent cooling in water.EFFECT: result is reduction of grain in metal of forged piece and prevention of cracking.1 cl, 2 tbl, 1 ex