Patent SG-11201901376P-A (SG)
Title: Pharmaceutical composition and methods of uses
Inventor: LI YUHUA
IPC: C07D405/04
Filed: 2017-08-18
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111 111111111101111101001111110111100111111111111011111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/035459 Al 22 February 2018 (22.02.2018) WIP0 I PCT (51) International Patent Classification: A61K 31/4166 (2006.01) C07D 405/04 (2006.01) (21) International Application Number: PCT/US2017/047609 (22) International Filing Date: 18 August 2017 (18.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/377,427 19 August 2016 (19.08.2016) US (71) Applicant: CHEN, Zunxuan [US/US]; 1 Innovation Way, Suite 100, Suite 100, Newark, Delaware 19711 (US). (72) Inventors: LI, Yuhua; 116 Ridgewoord Drive, Landen- berg, Pennsylvania 19350 (US). HUANG, ChiaTing; 4F., No.29, Ln. 59, Yixing St., Xizhi District, New Taipei City, 221 (TW). MAO, John; 804 Skycrest Drive, San Bruno, California 94066 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) = Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (84) = Published: — with international search report (Art. 21(3)) Il ON (54) Title: PHARMACEUTICAL COMPOSITION AND METHODS OF USES ir) i v (57) : Pharmaceutical Composition and Methods of Uses The present invention provides compositions or formulations com- l.() prising the combination of a compound of 543-(4-benzyloxyphenylthio)-fur-2-y1]-imidazolidin-2,4-dione or a salt thereof or hydrate M of the foregoing, and a cyclodextrin; or in further combination with an excipient comprising L-Arginine or other additives, wherein 0 ---. the compositions or formulations increases water solubility and oral bioavailability of 543-(4-benzyloxyphenylthio)-fur-2-y1]-imida- *1 : zolidm • -2,4-dione and its related compounds. The method of making or using the compositions or formulations is also disclosed. Such 1-1 c;;;;) compositions or formulations may be used in treatment of certain diseases including asthma through inhibition of matrix metallopro- -12. ei teinase C