baber/WOPTO huggingface dataset:
Patent PT-559164-E (PT)
Inventor: JOHANN KARL DR
IPC: G01N33/531
Filed: 1993-03-03
Abstract: The invention relates to a method for determining the content of a particular haemoglobin derivative in a blood sample. Specifically, the invention relates to a method for determining the content of haemoglobin derivatives, such as glycated haemoglobin (HbAlc), which require separate determination of the total haemoglobin content and determination of the haemoglobin derivative, in order to determine the content of the derivatised haemoglobin in the blood, and to a haemolysis reagent which is suitable for this purpose and contains an ionic detergent.
Patent PT-633929-E (PT)
Inventor: STEINMAN RALPH M
IPC: A61K35/12
Filed: 1993-04-01
Abstract: A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis.
Patent PT-666747-E (PT)
Inventor: ALAN WASCHBURN SCOTT
IPC: A61P9/10
Filed: 1993-11-01
Abstract: This invention provides a method of lowering cholesterol and blood lipid levels, preventing hypercholesterolemia, hyperlipidemia, cardiovascular disease, atherosclerosis, and peripheral vascular disease comprising administering an effective amount of 17 alpha -dihydroequilenin or a mammalian metabolic conjugate thereof to a mammal in need thereof.
Patent PT-705109-E (PT)
Inventor: HANCOCK GERALD E
IPC: A61K39/12
Filed: 1994-05-24
Abstract: PCT No. PCT/US94/05833 Sec. 371 Date Sep. 16, 1996 Sec. 102(e) Date Sep. 16, 1996 PCT Filed May 24, 1994 PCT Pub. No. WO94/27636 PCT Pub. Date Dec. 8, 1994Vaccine formulations and therapeutic methods therefor containing respiratory syncytial viral proteins or immunological fragment and an adjuvant selected from the group consisting of QS-21 3-deacylated monophosphoryl lipid A, monopohosphoryl lipid A and combination are described herein. Presence of the adjuvant(s) significantly increases the humoral and cell-mediated immunogenicity of the RSV proteins.
Patent PT-699754-E (PT)
Inventor: TAVTIGIAN SEAN V
IPC: C12Q1/68
Filed: 1995-08-11
Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers.
Patent PT-831087-E (PT)
Inventor: BRIEDEN WALTER
IPC: C07D211/82
Filed: 1997-09-15
Abstract: Production of 1-acyl-4-arylpiperidine compounds of formula (I) comprises (a) reaction of an aryl magnesium halide of formula R1-Mg-X1 (II) with a 1-acylpyridinium halide of formula (III) in the presence of a copper compound and (b) hydrogenating the resulting 1-acyl-4-aryl-1,4-dihydropyridine (IV) under homogeneous catalysis. (III) are obtained by reaction of pyridine with an acyl halide of formula R2-CO-X2 (V). R1 = aryl optionally substituted by 1 or more Q; Q = 1-6C alkyl, 1-6C alkoxy, benzyloxy, 1-6C alkylthio and/or F; R2 = 1-6C alkyl; 1-6C alkoxy; aryl optionally substituted by 1 or more Q; arylalkyl; or benzyloxy optionally ring-substituted by 1 or more Q; X1 = Cl, Br or I; X2 = Cl or Br. Also claimed are compounds (IVa) (= compounds IV with R1 = phenyl optionally substituted by 1 or more Q and R2 = benzyloxy). Preferably the Cu compound is Cu(I) iodide and the catalyst is a rhodium-phosphine complex (VI), especially (PPh3)3-Rh(I) chloride.
Patent PT-883873-E (PT)
Inventor: CASTOR ROBERT
IPC: G08G5/06
Filed: 1997-02-28
Abstract: An airport surface movement guidance and control system (SMGCS) involving detection, integrated processing and graphical display of the relevant, in particular the safety-relevant, positions and movements of aircraft, and optionally, vehicles, on airside (runway, taxiways, apron) and in the relevant airport airspace. At least one radar detects the positions and movements between airborne and parked positions of the aircraft. The relevant data are displayed after data concentration on the monitor of at least one controller station in graphical form and/or letter or number form. As a result, the operational management of the surface movement can be planned and executed from the at least one controller station by means of solely the SMGC system.
Patent PT-943675-E (PT)
Inventor: FRISCHE RAINER
IPC: A23L27/10
Filed: 1998-03-13
Abstract: Solvent extraction of hydrophobic compounds (I) from a crushed mixture which is (virtually) fat-free comprises making the mixture into a kneadable mass or pulp containing  NOTLESS  40 wt.% water, mixing with 15-65 wt.% water-soluble organic solvent (III) and also a water-soluble organic solvent and separating in one stage by malaxation in a centrifugal field. Solvent extraction of hydrophobic compounds (I) from a crushed mixture, which a priori is free from fat, oil and wax or strongly defatted, deoiled or dewaxed, with selective apolar extractant(s) (II) comprises (i) making the mixture into a kneadable mass or pulp containing  NOTLESS  40 wt.% water, with addition of water before or after crushing if necessary; (ii) mixing with 15-65 wt.% water-soluble organic solvent (III), depending on the water content, and between 10 vol.% and preferably 100 vol.% (II), depending on the (I) content; and (iii) one-stage separation, by malaxation in a centrifugal field, into (a) a solid sediment, (b) an aqueous phase containing (III) and (c) a clearly separate upper phase with relatively low density, consisting of (II) containing dissolved (I)
Patent PT-1007857-E (PT)
Inventor: ULRIKKEHOLM TORBEN
IPC: F16B5/02
Filed: 1998-06-03
Abstract: The invention relates to a screwing head, i.e. the screw nut (1) or the screw; especially the screwing head (2) of a screw connection. The aim of the invention is to provide a means for forming a screw connection as easily as possible using a distance sleeve (4). The inventive screwing head (1, 2) is characterised in that a tubular distance part (4) is arranged on the front face at the screwing end in such a way that it is able to turn but cannot be lost.
Patent PT-1059851-E (PT)
Inventor: DOAT STEPHANE
IPC: A23L29/20
Filed: 1999-03-04
Abstract: The invention concerns a stable homogeneous emulsifier-free suspension of at least one hydrophobic substance and/or a substance whereof the melting point is higher than about 130° C., and a thickening agent, in an aqueous medium. Said suspensions can be used in food compositions, in particular based on milk and milk derivatives.
Patent SG-38990-G (SG)
Title: Watch case
IPC: G04B37/08
Filed: 1990-06-02
Abstract: The watch case including a back cover, a caseband, a crystal, the peripheral zone of which entirely covers the caseband, a casing ring including at least one packing, a pair of supports facing one another fixed to the caseband and forming therewith a slot in which the crystal may be engaged and means for displacing the casing ring in order to compress the packing against the internal surface of the crystal and block said crystal against the supports. The crystal exhibits at least in its peripheral zone a spherical form of constant thickness. The upper surface of the caseband has the form of a part of a sphere the radius of which is substantially equal to that of the internal surface of the crystal. During assembly the internal surface of the crystal is made to slide over the upper surface of the caseband with a rotational motion resulting from the sliding of a spherical surface over part of a sphere.
Patent SG-98692-G (SG)
Title: Plastic injection-moulding unit with an interlocking device for a plastification cylinder and screw conveyor
IPC: B29C45/47
Filed: 1992-09-29
Abstract: An apparatus for locking a horizontal plasticizing cylinder to the carrying block of the injecting unit of an injection molding machine having two cylinder-locking sliders which are disposed on opposite sides of the axis of said cylinder and are radially movable by means of hydraulic cylinders. In a locking position, the sliders extend in diametrically opposite recesses of the plasticizing cylinder. A shaft for driving the feed screw of the plasticizing unit has a coupling section which is formed with a radial guide groove, in which a screw-locking slider is radially displaceably mounted, the screw-locking slider being non-rotatably connected to the shaft. A coupling bridge is secured to the upper one of the cylinder-locking sliders. When the feed screw is in a desired angular position said coupling bridge is coupled to the screw-locking slider so that one cylinder-locking slider and the screw-locking slider are simultaneously moved to their locking positions.
Patent IE-40477-L (IE)
Title: Androstane derivatives.
IPC: A61K31/565
Filed: 1975-01-17
Abstract: 1492746 #<SP>2</SP>-Androstenes THERAMEX SA 17 Jan 1975 [17 Jan 1974] 02211/74 Heading C2U [Also in Division A5] The invention comprises 17α-ethynyl-5α- androst-2-en-17#-ol and its acetate free from their respective #<SP>3</SP>-isomers; and their preparation from the analogously pure corresponding 17-one by reaction with an alkali metal salt (simple or complex) of acetylene, followed when required by acetylation. 5α - Androst - 2 - en - 17 - one is freed from admixed #<SP>3</SP>-isomer thereof by treatment with Jones reagent and isolation of the pure #<SP>2</SP> compound from the resultant mixture, e.g. by crystallization or chromatography. (The #<SP>3</SP>- isomer is thought to be converted to a diacid or aldehyde while the #<SP>2</SP>-isomer remains unchanged). The inventive compounds are credited with pituitary gonadotrophin-stimulating, gonadinhibiting, antitumour, contraceptive, anti-parathyroid and anti-seborrhoeic activities, and may be made up with carriers into pharmaceutical compositions for oral, parenteral, topical and rectal administration.
[GB1492746A]
Patent IE-900504-L (IE)
Title: Piperidine compounds and their preparation and use
IPC: A61P25/28
Filed: 1990-02-13
Abstract: The present invention relates to therapeutically active piperidine compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
[EP0384288A2]
Patent IE-39118-L (IE)
Title: Substituted alkanes; insecticides
IPC: A01N43/08
Filed: 1974-04-05
Abstract: Novel 1,7-dienes and addition products thereof possessing juvenile hormone-like activity have been prepared. Such a compound is one having the formula Z1Z2 ¦¦ Y-CH=CH-CH2CHCH2CH2CH-C-R3 ¦¦ R1R2 wherein each of R1, R2 and R3 can be hydrogen or C1-C3 alkyl, and Z1 and Z2 separately can be hydrogen or halogen or together can be a carbon to carbon bond, and Y is thienyl, furyl, naphthyl, phenyl or phenyl substituted by one or two substituents selected from chloro, bromo, fluoro, carboethoxy, cyano, C1-C4 alkyl, C1-C3 alkoxy, nitro, methylenedioxy, ethylenedioxy, dimethylamino or diethylamino. A compound exemplary of my invention is 4,8-dimethyl-1-(3,4-methylenedioxyphenyl)-1,7-nonadiene.
[US3923832A]
Patent IE-840902-L (IE)
Title: Spacing articles for a packaging machine
IPC: B65G47/28
Filed: 1984-04-12
Abstract: A spacer and conveyor mechanism for a packaging machine in which articles can be conveyed along a feed path and grouped together for subsequent packaging of each group into a discrete unit. The mechanism has a series of spacer and conveyor elements (94) constrained cyclically to execute a working and return motion such that the elements move along a working path in the feed direction of the articles during which the elements interfere with the articles in the feed path so as to form and convey said groups along the feed path and move along a return path opposite to the feed direction of the articles during which said elements are remote from said articles. The working and return paths are substantially parallel to the feed path, and the spacer and conveyor elements each have an operative face adapted to convey said articles in spaced relationship. The elements are mounted so that they are held throughout their cyclic movement with their operative faces facing towards the feed path.
Patent FI-812970-L (FI)
Inventor: BRACHT WERNER
IPC: H01R4/48
Filed: 1981-09-23
Abstract: 1. A contact sleeve (3) with a screwless connecting terminal for electrical sockets, which is fastened in a contact support (1) inside a recess (2) which opens onto the front end of the contact support, the connecting terminal consisting of a clamping plate (4) and a clamping spring in the form of a two-armed flat spring, the flat spring (9) being supported in a fixed manner by means of its support arm (10) and being pushed by means of its clamping arm obliquely in the insertion direction of a conductor (18) against the clamping plate (4) for securing at least one conductor (18), with extensions (12) which are integrally formed on the free end of the clamping arm and, for the purpose of disconnecting a conductor (18), penetrate a break (13) in the clamping plate (4), the lateral walls (5) of the clamping plate (4) being bent at the longitudinal sides extending in a parallel manner in the insertion direction of the conductors (18), between which lateral walls the clamping spring (9) is guided and which lateral walls have extensions (6) in the insertion direction of the conductors (18), which extensions are provided with semicircular widenings (7) to form the plug contact sleeve at their free ends for receiving a plug pin, a wall (17) being bent at the lateral edge of the clamping plate (4) which lies between the extensions, by means of which wall the introduction of the conductors (18) is limited and the contact sleeve (3) being secured on the contact support (1), in the area of its connecting terminal by means of extensions, characterised in that inwardly projecting lugs (8) are integrally formed on the lateral walls (5) behind which lugs the support arm (10) of the clamping spring (9) engages and is held in a frictionally clamped manner, in that the lateral walls (3) penetrate breaks (15) in the contact support (1) by means of integrally formed tongues (14) and are held by folded ends (16) on the contact support (1), and in that the semicircular widenings (7) of the extensions (6) forming the contact sleeve (3) are bent inwards through 180 degrees.
Patent FI-824295-L (FI)
Inventor: KRUEGER HORST
IPC: D21C9/10
Filed: 1982-12-14
Abstract: 1. A process for the production of half-bleached cellulose pulps by applying excess oxygen pressure, hydrogen peroxide and sodium silicate in an aqueous alkaline suspension, characterised in that for bleaching and partial delignification, oxygen, hydrogen peroxide and sodium silicate are simultaneously allowed to act on the cellulose pulp.
Patent IE-34613-L (IE)
Title: Imidazolidine benzenesulphonamide derivatives
IPC: C07D233/46
Filed: 1970-09-03
Abstract: 1,269,000. Compositions comprising sulphonamide derivatives. J. R. GEIGY A.G. 3 Sept., 1970 [4 Sept., 1969], No. 42108/70. Heading A5B. [Also in Division C2] Pharmaceutical preparations exhibiting, in particular, hypoglycaemic action contain I (including salts thereof) as active ingredient (R 1 is C 1 to 6 alkyl, allyl or C 5 to 8 cycloalkyl or -alkenyl, R 2 is H, Me or Et, R 3 is C 1 to 6 alkyl, allyl, Ph, phenalkyl of up to 9C or a cycloalkyl group having at most 8C and m is 2 or 3). Administration may be orally or parenterally and other compounding ingredients which may be incorporated are sulphonyl - ureas, e.g. p - toluenesulphonyl - butyl urea, p - chlorobenzenesulphonyl - propyl urea and p-[2-(2-methoxy-5-chlorobenzamido) - ethyl] - phenylsulphonyl - cyclohexyl urea, and ascorbic acid.
[GB1269000A]
Patent IE-791379-L (IE)
Title: Treating substances in different phases
IPC: F23G7/00
Filed: 1979-08-08
Abstract: 1. Apparatus for treating substances in the form of a liquid, semi-liquid or pasty phase, with another phase, in particular a gaseous phase, comprising a combustion chamber (1) and a contacting chamber (2), said combustion chamber comprising a casing (3) which is closed in its upper portion by an end plate (4), an annular space (6) which is delimited internally by an internal perforated wall (7), a restricted passage (10), at least one conduit (8) for the tangential feed of a gaseous phase, and a means (5) for axial injection of the fuel through the end plate (4), characterized in that the casing (3) terminates at the downstream end with a convergent portion (9) in which an injection device (11) terminates substantially at the level of the restricted passage (10), on the axis of rotation of the combustion chamber (1), the contracting chamber (2) extending the combustion chamber (1) in a downstream direction on the same axis of rotational symmetry.
[EP0007846A1]
Patent IE-39566-L (IE)
Title: Connecting scaffolding members.
IPC: E04G7/30
Filed: 1973-08-22
Abstract: 1427147 Releasable fastenings RAPID METAL DEVELOPMENTS Ltd 21 Aug 1973 [7 Sept 1972] 41516/72 Heading E2B Releasable fastening means for connecting together a pair of members wherein one of the members 10 has a hollow bracket 14 and the other member 11 has a lug 18 formed with a recess 19 receivable in the bracket when the lug is inserted through an aperture 17 in the bracket, includes a wedge 20 having a first surface 21 engageable with the recess 19 when the lug is disposed within the bracket and when the wedge is in an operative position, as shown in full line, releasably to secure the lug to the bracket, and a recess 22 formed in a second surface which is opposite the surface 21, the recess being engageable with a portion, i.e. the web 15, of the bracket when the wedge is in an inoperative position wherein the surface 21 is disengaged from the recess 19 so that the lug can be removed or inserted into the bracket; the recess 22 is so disposed that it is within the bracket when the wedge is in the operative position thereof. As shown, the member 10 is in the form of a sleeve secured to a scaffold tube 12 and receives a second tube 13, the bracket being of channel form, and the wedge has a recess 23 which allows withdrawal of the lug when the wedge is in its inoperative position.
[GB1427147A]
Patent IE-811779-L (IE)
Title: Blood filtering process
IPC: B01L3/14
Filed: 1981-08-04
Abstract: A composition and process for permitting the separation of plasma or serum from whole blood. The composition includes glass fibers having an average diameter of from 0.2 mu to 5 mu and a density of 0.1 g/cm2 to 0.5 g/cm2. The process includes the steps of slowly trickling whole blood onto one side of a layer composed of the composition of glass fibers, whereby plasma or serum separated from the blood becomes available at another side of the layer. The total volume of the plasma or serum separated from the blood is limited to at most 50% of the absorption volume of the glass fiber layer.
[US4477575A]
Patent IE-792027-L (IE)
Title: Pyrroloazetidinones
IPC: C07C205/42
Filed: 1979-10-23
Abstract: Disclosed are 6-, 1 - and 2-substituted-1-carbadethiapen-2-em-3 -carboxylic acids having the structure: <CHEM> wherein: R<0> is H or -SR<8>; R<1>, R<6>, R<7> and R<8> are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable sale ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds and pharmaceutical compositions comprising such compounds.
[EP0010317A1]
Patent IE-852367-L (IE)
Title: Coating or caulking compositions
IPC: C09D5/02
Filed: 1985-09-25
Abstract: Water-based coating or caulking compositions especially for exterior surfaces or seams which upon application quickly develop resistance to being washed out by rain comprise an aqueous dispersion of water-insoluble latex polymer prepared by emulsion polymerization, pigment dispersed with anionic polymer, and water-soluble salt of multivalent complex ion having ligands selected from ammonia or organic amine, and have a total solids content of from 50% to 90% by weight. Those compositions having a pigment to binder ratio of 1:1 to 3:1 are particularly useful as roof mastics.
Patent IE-40630-L (IE)
Title: Clindamycin 2- phosphates
IPC: A61P31/04
Filed: 1974-11-29
Abstract: 1465209 Clindamycin-2-phosphate derivatives UPJOHN CO 19 Nov 1974 [17 Dec 1973] 49949/74 Headings C2P and C2C The invention comprises compounds of Formula I and the acid addition salts thereof; where Halo is Cl, Br or I; X is -P(O)(OH) 2 , the zwitterion thereof or a partial salt thereof; R is C 1-4 alkyl and R 1 is C 1-8 alkyl; and their preparation by (1) protecting the 3- and 4-hydroxy groups in a corresponding compound in which X is H by reaction with an aldehyde or ketone to form an -ylidene group, (2) protecting the primary OH group by tritylation, silylation or formation of a 2-tetrahydropyranyl ether, (3) phosphorylation and (4) removal of protecting groups. In an example 1<SP>1</SP>- demethyl - 1<SP>1</SP> - (2 - hydroxyethyl)- clindamycin - 2 - phosphate hydrate (Formula I) is prepared by reacting 1<SP>1</SP>-demethyl-1<SP>1</SP>-(2- hydroxyethyl)clindamycin with acetone to give the corresponding 3,4-O-isopropylidene derivative, reacting this with trityl chloride to give the corresponding 1<SP>1</SP>-(2-trityloxyethyl) derivative, reacting this with pyridinium and cyanoethyl phosphate and then with aqueous acetic acid to give 1<SP>1</SP> - demethyl - 1<SP>1</SP> - (betahydrozyethyl)- clindamycin-2-cyanoethylphosphate and finally hydrolysing this ester. Antibacterial compositions for parenteral administration comprise a compound of the invention and a carrier.
[GB1465209A]
Patent IE-892501-L (IE)
Title: Hirudin-coated biocompatible substance
IPC: A61L27/00
Filed: 1989-08-02
Abstract: Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or fragment thereof.
Patent IE-42209-L (IE)
Title: 1-alkyl-2-(phenoxymethyl)-5-nitro-imidazoles
IPC: C07D233/94
Filed: 1975-12-15
Abstract: 1-Alkyl-2-(phenoxymethyl)-5-nitro-imidazoles are described as well as a process for their manufacture. The compounds are active against trichomonads and amoebae and are especially suitable for the treatment of Fluor genitalis.
[US4031232A]