baber/WOPTO huggingface dataset:
Patent NZ-230154-A (NZ)
Title: Imidazolyl-substituted 6- or 7-membered ring lactam derivatives and pharmaceutical composition
Inventor: COATES IAN HAROLD
IPC: A61K31/415
Filed: 1989-08-01
Abstract: The invention relates to tricyclic lactams of the general formula (I)   <CHEM>  wherein Im represents an imidazolyl group of the formula: <CHEM> and R<1> represents a hydrogen atom or a group selected from C1-6alkyl, C3-6alkenyl, C3-10alkynyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl-, phenyl, phenylC1-3alkyl-, -CO2R<5>, -COR<5>, -CONR<5>R<6> or -SO2R<5> (wherein R<5> and R<6>, which may be the same or different, each represents a hydrogen atom, a C1-6alkyl or C3-7cycloalkyl group, or a phenyl or phenylC1-4alkyl- group, in which the phenyl group is optionally substituted by one or more C1-4alkyl, C1-4alkoxy or hydroxy groups or halogen atoms, with the proviso that R<5> does not represent a hydrogen atom when R<1> represents a group -CO2R<5> or -SO2R<5>); one of the groups represented by R<2>, R<3> and R<4> is a hydrogen atom or a C1-6alkyl, C3-7cycloalkyl, C3-6alkenyl, phenyl or phenylC1-3alkyl- group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6alkyl group;  Y represents the group CH=CH or (CH2)n, wherein n represents 2 or 3; Q represents a halogen atom, or a group selected from hydroxy, C1-4alkoxy, phenylC1-3alkoxy-, C1-6alkyl, cyano, phenyl which may be unsubstituted or substituted by one or more C1-4alkyl, C1-4alkoxy or hydroxy groups or halogen atoms, -NR<7>R<8>, -CONR<7>R<8> or -(CH2)pCONR<7>R<8> (wherein R<7> and R<8>, which may be the same of different, each represents a hydrogen atom or a C1-4alkyl or C3-4alkenyl group, or together with the nitrogen atom to which they are attached form a saturated 5 to 7 membered ring; and p represents 1,2 or 3), -(CH2)qNR<9>R<1><0> (wherein R<9> represents a hydrogen atom or a C1-4alkyl group, and R<1><0> represents a group -COR<1><1> or -SO2R<1><1> wherein R<1><1> represents a C1-4alkyl group; and q represents 0, 1, 2 or 3), or -(CH2)2CO2R<1><1>(R<1><1> being as defined previously);  Q min  represents a hydrogen or a fluorine atom;  and physiologically acceptable salts and solvates thereof. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.
Patent NZ-233365-A (NZ)
Title: Screening for iga induction potential and bifidobacterium strains with such potential
Inventor: HISAKO YASUI
IPC: C12N5/078
Filed: 1990-04-19
Abstract: The present invention is to provide an easy, rapid method for screening a great amount of substances having IgA induction potential. The IgA induction potential herein mentioned means the potential to activate and enhance the activity of IgA production cells to produce secretory-type IgA in response to antigen. The present invention is to provide bacterial strains of genus Bifidobacterium obtained by the method for screening substances having IgA induction potential. More specifically, the present invention is to provide YIT 4061, YIT 4062 and YIT 4063. The three strains obtained by the present invention have strong IgA induction potential. Due to the fact that the Bifidobacterium strains have been known not to show any pathogenicity for humans and animals, the IgA induction potential of the three strains may be considered to be the one as adjuvant actions as non-specific stimulation of antibody production cells to process antigen more effectively, along with antigenicity as foreign bodies of themselves.
Patent NZ-234264-A (NZ)
Title: N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
Inventor: HORWELL DAVID CHRISTOPHER
IPC: C07D403/00
Filed: 1990-06-27
Abstract: Novel unnatural dipeptoids of  alpha -substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents and antiulcer agents and are agents useful for preventing the withdrawal response produced by chronic treatment or use followed by chronic treatment followed by withdrawal from nicotine, diazepam, alcohol or cocaine. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare pharmaceutical and diagnostic compositions.
Patent NZ-249007-A (NZ)
Title: Compositions containing lanthionine-containing bacteriocin (eg nisin) and their use
Inventor: BLACKBURN PETER
IPC: A61K35/74
Filed: 1993-01-15
Abstract: Compositions comprising lanthionine-containing bacteriocins such as nisin act as bactericides under conditions such as those found in the gastrointestinal tract. In a preferred embodiment pharmaceutical preparations containing the compositions are used for the control of bacteria responsible for disorders of the gastrointestinal tract.
Patent NZ-255478-A (NZ)
Title: Seal: pliant gel carried by elastomeric o-ring
Inventor: FRANCKX JORIS ISABELLA
IPC: F16J15/14
Filed: 1993-08-25
Abstract: PCT No. PCT/GB93/01809 Sec. 371 Date Apr. 28, 1995 Sec. 102(e) Date Apr. 28, 1995 PCT Filed Aug. 25, 1993 PCT Pub. No. WO94/05935 PCT Pub. Date Mar. 17, 1994A sealing member having: a sealing material having a cone penetration between 80 and 400 (10-1 mm) and an ultimate elongation of at least 100%, and an elastomeric retaining member for the sealing material. The retaining member in the form of two connected concentric O-rings.
Patent NZ-260338-A (NZ)
Title: Polyanhydroaspartic acid having substantially biodegradable hydrolysates, their preparation and use as detergent builders
Inventor: BOSSONNEC VERONIQUE
IPC: C08G73/10
Filed: 1994-04-18
Abstract: Polyanhydroaspartic acid whose hydrolysates exhibit a biodegradability in natural environment of at least 90% +/- 5%, characterised in that it contains not more than 3% of NH groups of its imide units relative to all the CH groups of its succinimide units. Its hydrolysates are characterised in that they contain not more than 3% of primary amide groups relative to the secondary amide groups included in the aspartic units. Polyanhydroaspartic acid and its hydrolysates can be obtained by thermal polymerisation of aspartic acid followed by optional hydrolysis, the said polymerisation operation being carried out in the presence of a boron derivative containing at least one B-OH bond or of a precursor of the said boron derivative. The latter can be employed as a "builder" or "cobuilder" in detergent compositions.
Patent NZ-260471-A (NZ)
Title: Monomeric bile acid derivatives and medicaments
Inventor: GLOMBIK HEINER
IPC: C07J9/00
Filed: 1994-05-06
Abstract: Monomeric bile acid derivatives of the formula I  Z-X-GS      I, in which GS, X and Z have the stated meanings, and processes for their preparation are described. The compounds have valuable pharmacological properties and can therefore be used as medicines.
Patent NZ-315469-A (NZ)
Title: Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
Inventor: HUTCHINSON DOUGLAS K
IPC: A61K31/4439
Filed: 1996-08-13
Abstract: his compound is of formula (I), or pharmaceutical acceptable salts thereof wherein X is NR1, S(O)g, or O; R1 is H, C1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R1 is -(CH2)h-aryl, -COR1-1, -COOR1-2, -CO-(CH2)h-COR1-1, C1-6 alkyl sulfonyl,-SO2-(CH2)h-aryl, or -(CO)i-Het; R2 is H, C1-6 alkyl, -(CH2)h-aryl, or halo; R3 and R4 are the same or different and are H or halo; R5 is H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy.  The compounds are useful antimicrobial agents.
Patent NZ-331538-A (NZ)
Title: Vibrating assembly for screening crushed rock
Inventor: PAOLIELLO BRIAN CHRISTOPHER
IPC: B07B1/46
Filed: 1997-02-27
Abstract: The screen assembly (10) comprises a support frame adapted to be mounted to a suitable support foundation.  A plurality of screen elements (20) are resiliently mounted to the support frame in a generally edge-to-edge relationship so as to define a generally planar screen surface.  A vibratory device (26) is connected to each of the screen elements (20) to individually vibrate the screen elements (20) relative to each other.  The vibration means (26) may comprise a pair of eccentrically weighted shafts (30, 32).  Alternatively the vibration means may comprise a pair of motors each of which is eccentrically weighted.
Patent NZ-336735-A (NZ)
Title: Volumetric infusion pump with automatic tube loading apparatus via cam actuated pawl
Inventor: ALLEN TIM
IPC: A61M5/142
Filed: 1997-03-21
Abstract: Tube loading pawls are typically rotatable on a layshaft and are cam actuated by a camshaft.
Patent NZ-336844-A (NZ)
Title: Epoxy-polysiloxane polymer composition for use as protective coatings that exhibit good weatherability and corrosion resistance after curing
Inventor: MOWRER NORMAN R
IPC: C08G59/14
Filed: 1997-05-06
Abstract: poxy-polysiloxane polymer compositions of this invention are prepared by combining a resin component with a hardener component. The resin component comprises a non-aromatic epoxy rein ingredient and a polysiloxyne ingredient of formula R2O-[Si-(R1)2]n-R2O. The hardener component comprises an amine and optionally an organotin catalyst. The composition can also include aggregates, pigments, and other additives depending on the particular end use. The composition is prepared using a sufficient amount of water to promote hydrolysis of the polysiloxane and the polycondensation of the silanols produced by such hydrolysis. In its cured form, the epoxy-polysiloxane composition exists as a uniformly dispersed arrangement of linear epoxy chain fragments that are cross-linked with a continuous polysiloxane polymer chain, thereby forming a non-interpenetrating polymer network chemical structure that has substantial advantages over conventional epoxy systems. Protective coatings formed from such compositions exhibit excellent weatherability in sunlight, and superior chemical and corrosion resistance after curing.
Patent NZ-337617-A (NZ)
Title: Cylinder lock and key with locking discs so that two or more different combination values can be selected for corresponding combination surface of the key
Inventor: MIELONEN PEKKA
IPC: E05B29/04
Filed: 1999-09-02
Abstract: A cylinder lock-key-combination has lock body 1, turntable lock cylinder 3 located inside the lock body 1 and having an axial slot 8, a set of locking discs 4, 6 located inside the lock cylinder 3 and provided with at least one peripheral notch 4b, 6b determining the opening combination of the lock and with opening 4a, 6a for a key, a locking bar 7, which in its locking position prevents turning of lock cylinder 3 with regard to lock body 1, and key 2 for the lock having a combination surface for each locking disc 4, 6 so that locking discs 4, 6 are rotatable by means of key 2 into positions in which peripheral notches 4b, 6b thereof form a uniform channel at the position of locking bar 7 and slot 8 in lock cylinder 3 into which locking bar 7 can enter releasing lock cylinder 3 to be rotatable with regard to lock body 1.  The lock has at least one locking disc 4 the key opening 4a of which includes ate least two separate counter surfaces 4a11, 4a12 which can be arranged in cooperation with one combination surface in key 2 corresponding to disc 4 in order to turn disc 4 into the opening position of the lock starting from the same initial position of the key 2.  The surfaces 4a11, 4a12 in the key opening 4a of said at least one locking disc 4 are so dimensioned and arranged with regard to each other that for the part of at least one of counter surfaces 4a11, 4a12 at least two different combination values can be selected for the corresponding combination surface to be made in the key 2.
Patent NZ-501614-A (NZ)
Title: Benzo[5,6]cyclohepta[1,2-b]pyridine derivatives useful for inhibition of farnesyl protein transferase
Inventor: COOPER ALAN B
IPC: C07D409/14
Filed: 1998-06-15
Abstract: Oxygen scavenging compositions composed of long chain branching copolymers and a transition metal compound are disclosed. The copolymers are comprised of units formed from ethylene and the vinyl unsaturated alicyclic compound of Formula I, wherein the C with the loop represents an unsubstituted or substituted C6-C12 non-aromatic ethylenic unsaturated alicyclic group. The composition may optionally also include a photoinitiator compound and/or a diluent polymer. The copolymer may optionally include units formed from a monomer selected from C3-C20 alpha-olefin, cycloolefin, non-conjugated dienes and mixtures thereof. Also disclosed is the use of the above compositions in packaging articles for oxygen sensitive articles, and methods for scavenging oxygen using packaging comprising of these compositions.
Patent NZ-513014-A (NZ)
Title: Non-phosphorous, non-metallic anti-wear compound and friction modifier
Inventor: WILLIAMSON WILL F
IPC: C10N40/25
Filed: 2000-01-19
Abstract: An anti-wear compound, comprising an intermediate adduct of a first moiety reacted in a first reaction with a second moiety to form the intermediate adduct and further esterifying the intermediate adduct with a third moiety in molar ratio of from about 1:2 to about 2:1. The first moiety is an unsaturated synthetic base oil or an unsaturated synthetic dieneophilic base oil, and the second moiety is a structure having a diene conjugated carbon-carbon double bond and a carboxylic acid or anhydride moiety. The first reaction comprises mixing the first moiety with the second moiety in a molar ratio of from about 1:2 to about 2:1 at a temperature of from about 220_C to about 320_C under an inert atmosphere, and wherein the third moiety is a polyhydroxy compound.
Patent NZ-513541-A (NZ)
Title: Piezoelectric spraying system for dispensing volatiles
Inventor: MARTENS EDWARD J
IPC: B05B17/00
Filed: 2000-02-09
Abstract: Disclosed herein is a piezoelectric liquid delivery system or atomizer for production of droplets of liquid or liquid suspensions by means of a battery operated dispenser utilizing an orifice plate (3) in communication with a piezoelectric element (2). By control of the viscosity and surface tension of the liquid to be dispersed, an improved method of dispensing such liquid is achieved.
Patent NZ-514226-A (NZ)
Title: Retracted pocket spring mattress; method for manufacturing of a pocket spring mattress and device for pre-tensioning pocketed coil springs
Inventor: EDLING KENNETH
IPC: A47C23/04
Filed: 2000-03-24
Abstract: A spring mattress comprising springs enclosed in casings and a method and a device for manufacturing such a mattress.  The spring mattress comprises a plurality of interconnected coil springs (1) enclosed in casings (2), for at least one of the springs, the casing portions arranged at the spring ends being moved towards each other, through the spring, and interconnected with the aid of connecting means.
Patent NZ-515785-A (NZ)
Title: Self injection device and method for its operation
Inventor: HJERTMAN BIRGER
IPC: A61M5/24
Filed: 2000-05-11
Abstract: An injector device, and a method for its operation. For containers  with an opening for an injection needle  e.g.  a syringe.  The  injector comprises a housing,  a  seat  or  a carrier  arranged  to  hold  the  needle  and  for  allowing movement thereof in relation to the housing between a  rear, needle  covering,  position and a forward,  needle  exposing position.  It  further  comprises a penetration  arrangement operable  to move the needle from the rear position  to  the forward  position, a return arrangement to move  the  needle in  the rearward direction, and an injection arrangement  to expel   container  content  through  the  needle.  It   also comprises  a control button arranged on the housing,  which, through  a transmission and a switch system, stepwise  trigs the  penetration arrangement and injection arrangement.  The button  is  arranged  to have a least a  movement  component perpendicular to the needle axis.
Patent NZ-517352-A (NZ)
Title: Hinge assembly for gaming machine belly door
Inventor: SOKOLOV RICHARD
IPC: E05D5/14
Filed: 2000-11-08
Abstract: A hinge assembly for a gaming machine comprises a hinge pin, fixed to a main door of a gaming machine and an outer sleeve (46) fixed to a belly door frame. The outer sleeve (46) comprises first and second arcuate arms so that the sleeve is part-annular in cross-section defining a gap between opposing ends of the arms. A support surface or ledge (49) is defined on an interior surface of the sleeve, below the top of the sleeve; A part-annular pin (86) element is fixed to a light chamber which in use is located behind the belly door frame. The pin (86) is rotatably mounted inside the outer sleeve (49) and includes a shoulder (85) which in use rests on the support surface (49) defined by the outer sleeve (46). A second gap is defined between free ends of the pin element (86). When the pin element (86) is rotated to a particular orientation with respect to the outer sleeve (46), the first and second gaps align to allow the pin element (86) and outer sleeve element (46) to be simultaneously mounted around the hinge pin. Subsequent relative rotation of the pin element (86) and outer sleeve (46) misaligns the gaps preventing the pin element (86) and outer sleeve (46) from becoming disengaged from the hinge pin.
Patent NZ-519709-A (NZ)
Title: Rapid onset formulation comprising pyridoxine HCL and doxylamine succinate
Inventor: GERVAIS ERIC
IPC: A61K31/4402
Filed: 2001-06-21
Abstract: Provided herein is an enterically-coated pyridoxine HCI and doxylamine succinate rapid onset formulation comprising a disintegrating agent such that the following dissolution profiles are satisfied when measured in 1000 ml phosphate buffer at pH 6.8 and 37 DEG C in tape 2 dissolution apparatus at 100 rpm: (a) at least about 40 % of the total pyridoxine HCI and doxylamine succinate is dissolved after 30 minutes of measurement; (b) at least about 70 % of the total pyridoxine HCI and doxylamine succinate is dissolved after 60 minutes of measurement; (c) at least about 80 % of the total pyridoxine HCI and doxylamine succinate is dissolved after 90 minutes of measurement; (d) at about 90 % of the total pyridoxine HCI and doxylamine succinate is dissolved after 120 minutes of measurement. Preferably the formulation will contain a core coated with at least one enteric coating, the core comprising pyridoxine HCI, doxylamine succinate and the following non-active excipients: a filler or binder, a disintegrating agent, a lubricant, a silica flow conditioner and a stabilizing agent.
Patent NZ-520207-A (NZ)
Title: Sterilizer test device
Inventor: BANKCROFT RICHARD
IPC: A61L2/28
Filed: 2000-12-18
Abstract: A re-usable sterilizer test device is disclosed which is comprised of at least two parts which are releasably connected together. An indicator device which changes colour in the presence of steam after a certain time period is deposited within the two parts. One or both of the bodies is manufactured from a material having a predetermined degree of porosity as regards steam and is generally cylindrical or spherical so that the outer surface of said one or both bodies forms a significant and substantial portion of the external surface of the assembled device. Steam penetrates the porous body and passes into a cavity inside the body from where the steam can move internally of the device through suitable passageways and into a chamber where the indicator is located.
Patent NZ-529166-A (NZ)
Title: Needleless valve
Inventor: DOYLE MARK CHRISTOPHER
IPC: A61M5/168
Filed: 2003-10-28
Abstract: A needleless valve 2 for use in medical liquid flow applications is described. The valve consists of three pieces; a base 4 with a connector 10 for attachment to tubing or other device; a flexible hollow expanding plug 6', which allows fluid flow when transformed into an activated state upon insertion of a fluid supply nozzle; and a tubular housing 8 fitting over the plug 6' and attached to the base. A rod on base 4 opens the slit 22 of plug 6' when the plug is in its larger activated state. Upon removal of the fluid nozzle the plug contracts, decreasing its interior volume and forcing residual fluid to be expelled through the outlet. No negative pressure is formed, so no suctioning of blood or other fluid from a patient or receiver occurs. (62) Divided out of 518655
Patent NZ-530797-A (NZ)
Title: Three dimensional structures and models for Fc receptors and uses thereof and processes for producing pharmaceutical compositions
Inventor: BAELL JONATHAN B
Filed: 1999-02-04
Abstract: A process of producing a therapeutic composition, that reduces IgG-mediated tissue damage and comprises an inhibitory compound that inhibits the activity of an Fcg receptor FcgR protein, comprises: a) identifying the inhibitory compound by the process comprising: i) providing a three dimensional structure of an FcgR protein selected from the group consisting of FcgRI, FcgRIIa, FcgRIIc and FcgRIIIb, wherein the three dimensional structure of the FcgR protein substantially conforms to atomic coordinates represented by Table 1 or Table 2 (as disclose din the specification); ii) using the three dimensional structure of the FcgR protein to design a compound selected from the group consisting of a compound that inhibits binding of FcgR protein to IgG, a compound that substantially mimics the three dimensional structure of FcgR protein and a compound that inhibits binding of FcgR protein with a molecule that stimulates cellular signal transduction through an protein; b) synthesizing the compound identified in (a); c) evaluating the ability of the synthesized compound to reduce IgG-mediated tissue damage; and d) formulating the synthesized compound with a suitable pharmaceutically acceptable carrier to produce the therapeutic compound. Also described are processes for producing therapeutic compositions that enhance IgG-mediated responses, reduce IgE-mediated responses or that enhance IgE-mediated responses.
Patent NZ-533015-A (NZ)
Title: Polypeptide and polynucleotide sequences encoding arthropod protein disulfide isomerases and uses thereof
Inventor: CAHOON REBECCA E
IPC: C12N15/61
Filed: 1999-10-14
Abstract: Nnucleic acid fragments encoding a protein disulfide isomerase is described. Also described is the construction of a chimeric gene encoding all or a portion of the isomerase, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the protein disulfide isomerase in a transformed host cell. The host cell can be selected from the group consisting of plant, insect, yeast, bacteria and virus. (62) Divided out of 510344
Patent NZ-533296-A (NZ)
Title: File system shell
Inventor: MOORE JASON F
Filed: 2003-05-16
Abstract: A file system shell provides virtual folders (651-655) which expose regular files and folders to users in different views, based on their metadata instead of the actual physical underlying file system structure. Users are able to work with the virtual folders (651-655) through direct manipulation. Filters (620-626) are provided for narrowing down sets of items. Quick links (610-613) generate useful views of the sets of items. Libraries (600) consist of large groups of usable types of items that can be associated together, along with functions and tools related to the items. A virtual address bar comprises a plurality of segments, where each segment corresponds to a filter for selecting content. A shell browser is provided with which users can readily identify an item based on the metadata associated with that item. An object previewer in a shell browser displays a plurality of items representing multiple item types.