baber/WOPTO huggingface dataset:
Patent CR-20150236-A (CR)
Title: Métodos para el tratamiento del síndrome de alport
Inventor: DUFFIELD JEREMY
IPC: C12N15/113
Filed: 2015-05-07
Abstract: Se proporcionan métodos para el tratamiento del síndrome de Alport, utilizando oligonucleótidos modificados a objetivo miR-21. En ciertas realizaciones, un oligonucleótido modificado a objetivo miR-21 mejoran la función renal y/o reducen la fibrosis en sujetos con síndrome de Alport.
Patent CR-20200567-A (CR)
Title: Anti-cd33 antibodies, anti-cd33/anti-cd3 bispecific antibodies and uses thereof
Inventor: NAIR-GUPTA PRIYANKA
IPC: C07K16/28
Filed: 2019-05-21
Abstract: <p>Anti-CD33 antibodies and antigen-binding fragments thereof and anti-CD33/anti-CD3 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.</p>
Patent CR-20210073-A (CR)
Title: Compositions and methods for immunotherapy targeting flt3, pd-1, and/or pd-l1
Inventor: YU JIANHUA
IPC: C12N5/0783
Filed: 2019-07-03
Abstract: CAR cells targeting FLT3 antigens in combination with a secreted anti -PD-1 and anti-PD-L1 antibodies or anti-PD-1-anti-PD-L1 bispecific antibodies are described as a new method of cancer treatment. It is proposed that these combination therapies are safe and effective in patients and can be used to treat human tumors and cancer.
Patent EC-SP055711-A (EC)
Title: Receptáculo de triplex/sixplex
Inventor: ODDSEN DENNIS
IPC: H01R25/00
Filed: 2005-03-30
Abstract: Está presentado un receptáculo para una unidad individual tríplex que tiene tres tomacorrientes, que puede ser montado en una caja individual, no requiere de un cableado separado que los conecte entre sí, y puede estar cubierto por una plaqueta individual. Está presentado también un receptáculo para una unidad individual síxplex que tiene seis enchufes que pueden ser montados en la pared en una caja doble, que no requiere cableado separado que los conecte entre sí, y puede estar cubierto por una plaqueta individual.La información anterior ha esquematizado, a grandes rasgos, la característica principal de la presente invención, de manera que quienes conozcan de la materia puedan comprender mejor la descripción detallada de la invención en la Memoria Descriptiva. Las características adicionales de la invención que se describen ahí forman el objeto de protección de la invención. Quienes conocen la materia pueden apreciar que de manera inmediata podrán hacer uso del concepto presentado y la representación específica como base para el diseño o modificación de otras estructuras que cumplan con los mismos propósitos de la presente invención y que estas otras estructuras no se derivan del espíritu y alcance de la invención en su forma más extensa.
Patent EC-SP077522-A (EC)
Title: Sistema de seguridad para tapas de alcantarilla, acueducto, telefonía y energía
Inventor: DESPINIADIS DIMOSTHENIS
IPC: E03F5/00
Filed: 2007-06-15
Abstract: Sistema de Seguridad para Tapas de Alcantarilla, Acueducto, Telefonía y Energía caracterizado porque consiste en que a la Tapa Electromecánica (1) se le coloca en su superficie una Grúa electromagnética (2) la cual tiene una manija (3), esta conformada por una bobina emisora (4), una batería (5), una tarjeta electrónica (6) y un panel de control (7); en el interior de la Tapa Electromecánica (1) se coloca una bobina receptora (8), tarjeta electrónica (12), dos motores (9), que se encuentran dentro de un espacio impermeable, que mueven un pasador (10) el cual tiene un fuelle (11) y están conectados a una tarjeta electrónica (12).El sistema opera de la siguiente manera:a)	La bobina emisora (4) transfiere la energía electromagnética a la bobina receptora (8), al mismo tiempo envía un código binario exclusivo. Esto produce la electricidad para operar los motores eléctricos que mueven los pasadores (10) que abren o cierran la tapa (1);b)	 Después de que la tapa (1) esta abierta produce un campo magnético constante de una sola dirección para poder levantar la Tapa Electromecánica (1), realizar los trabajos necesarios y volverla a colocar en su sitio y cerrarla.
Patent FI-20011948-A (FI)
Inventor: TURPEINEN MARKO
IPC: H04W4/029
Filed: 2001-10-05
Abstract: The present invention relates to a telecommunication system comprising: subscribers (MS), a location data source (4) for maintaining location data descriptive of the subscribers' location, and a service provider (2, 3) for providing the subscribers with subscriber location data-dependent content. In order for a subscriber's privacy not to be compromised because of the content provision, the location data source (4) is configured to transmit further a given subscriber's location data only upon reception of a location data inquiry including a validated credential. The system further includes a service provider (1), from which a given subscriber's credential is retrievable, and means (5) for transmitting a location data inquiry including the credential of the subscriber requesting for the content to the location data source (4), for transferring the location data transmitted from the location data source (4) to the content provider (2, 3). <IMAGE>
Patent FI-20020702-A (FI)
Inventor: VAEAENAENEN MIKKO KALERVO
IPC: H04B10/112
Filed: 2002-04-11
Abstract: The invention relates to the field of free space optics or more generally to communication below radio frequencies. Free space optical communication is plagued by interruptions in the connections caused by atmospheric phenomena, such as weather. In the invention, a wireless beam transmission system comprises at least one transmitter (110) and accommodates several wavelengths, and at least one transmission wavelength is arranged to be chosen based on spectral absorption measurements of the atmosphere in the carrier beam path of communication.  The invention concerns also a transceiver for repeating wireless optical communication signals. The long range and high reliability of spcctroscopically sensitive light beams at a penetrating frequency in accordance with the invention allow the affordable provisioning of high bandwidth optical or IR communication connections to devices and buildings that were previously either very expensively connected to the fiber optic backbone networks, expensive low bandwidth radio or microwave networks, or unreachable by traditional free space optics solutions.
Patent FI-20040564-A (FI)
Inventor: AULANKO ESKO
IPC: B65G23/44
Filed: 2004-04-22
Abstract: A people mover, such as a travelator, moving ramp or escalator, comprises a conveyor. The conveyor comprises a frame having a first frame part secured to a fixed structure, and a second frame part mounted to be movable in relation to the first frame part in the longitudinal direction. The first and second frame parts are arranged one after the other. Transport platforms are secured to a first drive element and a second drive element. The drive elements are endless elements. A first tensioning device tensions the first drive element and a second tensioning device tensions the second drive element. Each tensioning device acts between the first frame part and the second frame part. The conveyor additionally comprises mechanical transmission elements between the first and second tensioning devices for keeping the stroke lengths of the first and the second tensioning movements equal.
Patent FR-1170198-A (FR)
IPC: A61F2/06
Filed: 1956-10-25
Granted: 1959-01-09
Abstract: 851,993. Flexible pipes. CHEMSTRAND CORPORATION. Oct. 22, 1956, No. 32136/56. Drawings to Specification. Class 99(2). The subject-matter is identical with that of Specification 829,943 but the claims are limited to the tube being permeable to fluids.
Patent FR-1604123-A (FR)
Title: Nicotine acid esters of dextran and carboxymethyldextran - slow release form of nicotine acid
IPC: A61K47/48
Filed: 1966-08-22
Granted: 1971-07-12
Abstract: Nicotinic acid esters of dextran and carboxymethyldextran are prepd. by treating the polysaccharide with nicotinyl chloride or its hydrochloride in an acid-binding solvent such as pyridine or DMF for 1/2-3 1/2 hr. at 80-120 degrees C, diluting with water and collecting the pptd. ester.
Patent GB-1000739-A (GB)
Abstract: 1,000,739. Latches. REGIE NATIONALE DES USINES RENAULT. May 1, 1962 [May 29, 1961], No. 16634/62. Heading E2A. A lock assembly for an automobile slidable window 1 comprises a bolt 4 rigidly secured to and extending inwardly and at right angles to the window, a lock body 7 slidably mounted on the bolt and spring-biased towards the window, latching means 21 on the lock body 7 adapted to engage means fixed relative to the window frame when the lock body is urged towards the window and to disengage when the lock body is drawn away from the window. As shown, the bolt 4 is secured by a nut 3 and a distance piece 5 and the body is retained against a spring 6, whereby the latching means 21 in the form of an integral projection on the body 7 is engageable and disengageable with an elongated slot 18 at each end of a flange 17 of the window frame 16.
Patent GB-1047297-A (GB)
IPC: C08K5/3437
Abstract: 1,047,297. Anthrapyridone pigments. IMPERIAL CHEMICAL INDUSTRIES Ltd. April 8, 1965 [May 15, 1964], No. 20416/64. Heading C4P. [Also in Division C3] Bis(3-methyl-1<SP>1</SP>: 9<SP>1</SP>-anthrapyridon-6-yl) is obtained by heating 6-bromo-3-methyl-1<SP>1</SP>: 9<SP>1</SP>. anthrapyridone in the presence of copper bronze and dimethylformamide (see Example 3).
Patent GB-1051414-A (GB)
IPC: B60C5/04
Abstract: 1,051,414. Making inner tubes. DUNLOP RUBBER CO. Ltd. Feb. 12, 1964 [Feb. 25, 1963], No. 5810/64. Heading B5A. [Also in Division B7] Tyre inner tubes (see Division B7) are formed from tubular lengths of unvulcanized rubber which are extruded from an extruder 6 comprising a screw 7 disposed within a passageway 8, the passageway having an inlet 9 at one end and, at the other end, an annular die orifice 10 defined by the wall of the passageway and a central die part 11 secured radially within and spaced from the wall of the passageway. During extrusion, the inner surface of the formed tubular length is powdered with zinc stearate to prevent opposing sides of the inner surface adhering together.
Patent GB-1052449-A (GB)
IPC: H01L23/488
Abstract: 1,052,449. Semi-conductor devices. ALLM€NNA SVENSKA ELEKTRISKA A.B. Oct. 11, 1963 [Oct. 15, 1962], No. 40143/63. Heading H1K. A device e.g. diode, transistor or thyristor comprises a semi-conductor wafer alloyed or soldered to one face of a larger carrier plate the other face of which is in pressure contact with a cooling body. The carrier plate is of a material with a thermal expansion coefficient within 50% of that of the wafer. In a typical diode (Fig. 1) the wafer is of P-type silicon and is bonded to carrier plate 11 and electrode 13 by aluminium and gold-antimony respectively. Suitable carrier plate materials for silicon or germanium wafers are tungsten, molybdenum, chromium, tantalum, and specified iron-nickel and iron-nickel cobalt alloys. Sintered tungsten or molybdenum, with or without copper as binder, are preferred. Ceramic ring 14 is attached to the carrier plate 11 via a fernico ring 17 which is silver-soldered to the ring and gold-tin soldered to the plate. The plate is clamped to the finned copper aluminium or silumin body 21 as indicated, by an internally threaded clamping ring engaging a thread on the body, or by being itself screwed into a threaded hole in the body.
Patent GB-1138150-A (GB)
Abstract: 1,138,150. Ignition systems. L.W. BELL. Aug. 15, 1967 [Aug. 25, 1966], No.37367/67. Heading F1B. An ignition system has a coil with a primary winding 7 and a secondary winding 9 and a gas discharge tube 21 connected across the primary winding 7 for forming a resonant circuit therewith to produce multiple sparking. Two capacitors 19, 23 are associated with the primary circuit. A resistor 14 is employed in series with the primary circuit and automatic means may be provided to short out the resistor while the engine is being started. A first capacitor may be in parallel with the gas discharge tube and second and third capacitors connected to opposite sides of the primary winding the other sides of the capacitors being connected to earth. A fourth capacitor and gating circuit may be in parallel with the second capacitor, the gating circuit comprising a gas discharge tube with a diode connected across the tube. This embodiment is suitable for use with a rotary Wankel type engine.
Patent GB-1225891-A (GB)
IPC: C07B61/00
Filed: 1969-01-30
Abstract: 1,225,891. Process for acetylenic alcohols. RHONE - POULENC S.A. 30 Jan., 1969 [31 Jan., 1968], No. 5136/69. Heading C2C. Acetylenic alcohols are obtained by a process which comprises contacting a ketone with acetylene in N - methylpyrrolidone in the presence of sodium hydroxide in an amount from 1 to 10 mols per mol. of ketone, and under a pressure essentially equal to atmospheric pressure, i.e. a pressure equal to, or slightly greater than, atmospheric pressure and which can at most reach a value of 1.5 bars absolute. Ketones specified include those containing saturated or unsaturated aliphatic radicals and the production of dehydrolinalool utilizing 6 - methylhept- 5 - en - 2 - one is exemplified.
Patent GB-1227504-A (GB)
IPC: B01F33/40
Filed: 1969-08-21
Abstract: 1,227,504. Mixing apparatus. VOMETEC N.V. 21 Aug., 1969 [21 Aug., 1968], No. 41732/ 69. Heading B1C. Mixing apparatus comprises a vessel 2 having a detachable base provided with a discharge tube 10 having a vertically displaceable closure member 11, and annular spaces 15, 20, 24 encircling the tube 10 having inlets and outlets through which gases and/or liquids are introduced into the interior of the vessel to be mixed with or to agitate solids therein. The outlet from space 15 is in the form of one or more nozzles 17 and the outlet from space 20 is in the form of one or. more tubes 19 disposed in the nozzles. The outlet from space 24 is in the form of perforations in a perforated plate 8. In use, solids in the vessel may be fluidised by the introduction of a gaseous medium through the perforated plate and may be sprayed with a spray formed by introducing a liquid through tube(s) 19 and a gas through nozzle(s) 17.
Patent GB-1228956-A (GB)
IPC: H01C1/142
Filed: 1968-04-08
Abstract: 1,228,956. Printed circuit assemblies. WESTERN ELECTRIC CO. Inc. 8 April, 1968 [13 April, 1967], No. 16777/68. Heading H1R. A method of manufacturing a thin film integrated circuit comprises forming on a substrate a resistor layer, a metallic oxide protective layer, a capacitor electrode layer and a highly conductive layer, sequentially etching the layers to delineate circuit components and heating the etched assembly. A high-alumina ceramic or glass substrate 10 has a layer 12 of tantalum nitride deposited thereon followed by a sputtered layer 14 of tantalum pentoxide or alternatively the oxide layer may be formed by anodizing the nitride layer. Beta tantalum layer 16 is then deposited on the tantalum pentoxide and lastly a conductive layer of aluminium 18 is applied to layer 16. Contact pads 20, leads and capacitor areas 22 are delineated by a photoresist and the remaining areas are etched to the tantalum pentoxide layer 14. The entire area is then patterned with photoresist to delineate resistors and the tantalum pentoxide layer 14 and nitride layer 12 are etched to form resistor 24. Areas which serve as conductors or pads retain the beta-tantalum 16 and the aluminium 18 but the capacitor areas 22 are stripped of the aluminium for subsequent anodization. After anodizing to form the dielectric of the capacitor and trim-anodizing the resistor patterns counter electrodes are deposited on the capacitors and cross-overs are formed. The assembly is then heated in the range 300 to 600 C. so that the protective layer of oxide diffuses into the adjoining tantalum nitride and tantalum layers so that the whole layer is rendered conductive and noisegenerating pin holes become unimportant. In addition the heating eliminates back etching normally performed on Ta 2 O 5  dielectrics and effects temperature coefficient adjustment of the resistors. Instead of using aluminium as an overlay, a nickel chromium alloy gold overlay may be used or just gold. The nickel and gold layers may be deposited by an electroless process. Reference has been directed by the Comptroller to Specification 1,125,394.
Patent GB-1229417-A (GB)
IPC: B23K9/32
Filed: 1967-08-03
Abstract: 1,229,417. Feeding welding flux. BRITISH OXYGEN CO. Ltd. 25 July, 1968 [3 Aug., 1967], No. 35662/67. Heading B8S. Welding flux is discharged from hopper 4 down shoot 8, and its discharge is controlled by hollow tube 10 which is hand operated at 14 so that by raising the tube, the mouth of the shoot is open and by lowering the tube the mouth is closed, the handle 14 passing through an aperture formed in the hopper 4. Additionally tube 10 is provided with spring 18 which co-operates with abutment 16 to provide a seat for the tube.
Patent GB-1229849-A (GB)
IPC: F04D29/60
Filed: 1968-06-19
Abstract: 1,229,849. Centrifugal pumps. VORTEX A.G. June 19, 1968 [June 22, 1967], No.29093/68. Heading F1C. A pump assembly for connection in a pipeline has a removable casing portion containing the driving motor 1, Fig. 1, and the impeller 2. The casing portion is connected by a ring nut 3 to a base portion 4 having coaxial inlet and outlet connections 5, 6 provided with valves 8, 9 which when closed isolate the interior of the base portion from the pipeline. The valves 8, 9 are screwed on to threads of opposite hand at the ends of a hexagonal rod 11 which is rotatable by an external knob (16), Fig. 2 (not shown) via a worm 15 and wheel 14 to control the position of the valves, the valves being held against rotation by pins 17, 18 engaging axial slots in the valves. Leakage from the base portion is prevented by gaskets 19, 20, or by a gasket (21) surrounding a spindle (not shown) connecting the knob to the worm.
Patent GB-1231125-A (GB)
IPC: C07F7/18
Filed: 1969-11-06
Abstract: 1,231,125. Benzoin silyl ethers; photopolymerization. FARBENFABRIKEN BAYER A.G. 6 Nov., 1969 [6 Nov., 1968], No. 54468/69. Headings C3P and C3S. Benzoin silyl ethers of the general formula where R is H, C 1-4  alkyl or alkenyl, aralkyl or phenyl, R<SP>1</SP> is C 1-4  alkyl and R<SP>11</SP> and R<SP>111</SP> are H ,  halogen, C 1-4  alkyl or methoxy, are used as sensitizers in the photopolymerization of unsaturated compounds. They are prepared by reacting benzoins with compounds which split off trialkylsilyl groups, e.g., Me 3 SiCl, hexamethyldisilazane and N - trimethylsilylacetamide. A polar solvent such as pyridine, dimethyl sulphoxide or dimethylformamide may be present. Examples of photopolymerizable compounds are styrene, vinyl toluene, divinyl benzene, vinyl acetate and chloride, vinylidene chloride, vinyl methyl ketone, acrylic and methacrylic acids, esters, amides and nitriles, allyl acetate, allyl esters of phthalic and phosphoric acid, and unsaturated polyesters in combination with a co-monomer. Peroxide catalysts, inhibitors and accelerators may be incorporated. U.V. absorbers and fillers may also be added as well as thixotropic agents such as glass and synthetic fibres, silica and talcum. The sensitizers are particularly useful in the preparation of coating compositions containing paraffin or other wax. The radiation may be natural or artificial in the range of 250 to 580 mÁ.
Patent GB-1258440-A (GB)
IPC: H01H15/16
Filed: 1969-07-02
Abstract: 1,258,440. Inert switches. CHERRY ELECTRICAL PRODUCTS CORP. 2 July, 1969 [26 Dec., 1968], No. 33411/69. Heading H1N. A switch comprises a housing 15 containing an actuator 26 pivoted about pin 31 which fits in hole 32 in the end wall of housing 15 and has a lever 28 which projects through opening 23 in the front wall of housing 15, and a position indicator 33 carrying indicia 35 visible through opening 23 and rotatable about pin 24 on the end wall of housing 15, gear hub 36 meshing with teeth 30 on actuator 26, position indicator 33 carrying wiping contact 37 engaging printed circuit board 21. When lever 28 is moved, position indicator 33 is rotated. A detent spring 48 on the rear wall of housing 15 engages teeth 34 on the rear half of position indicator 33. The assembly is clamped between end plates 12, 13 with a second independently operated switch 11. Switch 11 may not be included. Pins 44 on housing 15 fit into apertures 43 in printed circuit board 21 and pins 51 on housing 15 fit into apertures 52 in switch 11 (or plate 13 if switch 11 is not provided) for locating purposes. In a modification, Fig. 5 (not shown), lever 28 is bent to the side away from opening 23.
Patent GB-1259387-A (GB)
IPC: A61K9/16
Filed: 1969-07-31
Abstract: 1,259,387. Granular material comprising glucofuranosides. CIBA-GEIGY A.G. 31 July, 1969 [5 Aug., 1968], No. 38539/69. Heading A5B. A solid, free-flowing granular material comprising an oily or liquid pharmacologically active glucofuranoside of the formula: wherein R 1  is H, cycloalkyl, benzyl, alkyl, alkenyl or hydroxyalkyl; R 2  is H or alkanoyl; R 3  is allyl, alkyl, benzyl, methylbenzyl or halogenobenzyl and R 5  and R 6  each represent benzyl, methyl benzyl or halogenobenzyl and one of R 3 , R 5  and R 6  may be H, adsorbed on magnesium trisilicate and, if desired, on a further adsorbing agent, and a film-forming agent is prepared by mixing the glucofuranoside with the film-forming agent and an alkanol, working up the mixture so obtained with magnesium trisilicate adsorbent to form a plastic mass which is granulated whilst it is drying. The film-forming agent may be shellac, a polyacrylic or methacrylic ester, an ethylene oxide polymer, a polyvinyl alcohol or an ester thereof e.g. polyvinyl acetate, polyvinylpyrrolidone or copolymers thereof, or a cellulosic derivative which is soluble in alcohol or water e.g. cellulose acetate phthalate, hydroxypropyl-methyl-, ethyl-, ethyl-hydroxyethyl-, hydroxypropyl-, or carboxymethyl cellulose. The further adsorbent may be colloidal silica or cellulose. The glucofuranoside may be ethyl- 3, 5, 6-tri-O-benzyl-O-glucofuranoside or ethyl- 3-O-propyl-5, 6-di-O-para-chlorobenzyl-D-glucofuranoside. Tablets and dragees may be formed from the granular material.
Patent GB-1265816-A (GB)
IPC: A47K10/36
Filed: 1969-03-17
Abstract: 1,265,816. Rolled web dispenser. ZELLSTOFFABRIK WALDHOF. March 17, 1969 [March 16, 1968], No.13802/69. Heading A4G. A paper towel dispenser has a delivery roller, rotatable manually at 12 over which the towel may be pulled from roll 4, the roller carrying an end disc containing a cut-out segment 14 along the edges of which moves a roller 15 on one end of rod 16 tensioned by spring 17. On turning anticlockwise, the delivery roller to an intermediate position, the roller 15 moves along the segment curve 20 from a top position near the edge of the disc to a position near the disc centre but on the opposite side of the centre from the top position, at which centre position the delivery roll is stopped by a timing mechanism, but the roller 15 moves up the straight edge of the segment to the top position under the influence of spring 17. At this point the towel is torn off. On release of the time controlled stop, the delivery roller is rotated to its initial position to project the leading edge of the next towel portion by the roller acting at the top of the segment under the influence of spring 17. The delivery roller may be braked by a leaf spring acting on a cam.