Patent SG-11201808525U-A (SG)
Title: Anti-complement factor bb antibodies and uses thereof
Inventor: PANICKER SANDIP
IPC: C07K16/18
Filed: 2017-04-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD IIIII01101010 11111 010111110111010111111111111111111011111111111110111111 International Bureau ... .... ..Yjd (10) International Publication Number (43) International Publication Date ..... ...,/ WO 2017/176651 Al 12 October 2017(12.10.2017) WIPO I PCT (51) International Patent Classification: (US). BYUN, Tony SangYoung; 234 Crescent Court, C07K 16/18 (2006.01) C07K 16/40 (2006.01) Brisbane, California 94005 (US). C07K 16/36 (2006.01) A61K 39/395 (2006.01) (74) Agent: JI-EUN, Kim; Sterne, Kessler, Goldstein & Fox (21) International Application Number: P.L.L.C., 1100 New York Avenue, N.W., Washington, DC PCT/US2017/025784 20005-3934 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 3 April 2017 (03.04.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (25) Filing Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (26) Publication Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (30) Priority Data: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 62/317,897 4 April 2016 (04.04.2016) US MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (71) Applicant: TRUE NORTH THERAPEUTICS, INC. NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, [US/US]; 951 Gateway Boulevard, South San Francisco, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, California 94080 (US). TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: PANICKER, Sandip; 951 Gateway Boulevard, South San Francisco, California 94080 (US). PARRY, (84) Designated States (unless otherwise indicated, for every Graham; 951 Gateway Boulevard, South San Francisco, kind of regional protection available): ARIPO (BW, GH, California 94080 (US). CHRISTOPHERSON, Karen GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Sue; 906 E. 3rd Avenue, San Mateo, California 94401 TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [Continued on next page] Title: ANTI-COMPLEMENT FACTOR BB ANTIBODIES AND USES THEREOF (54) 1.2 1.1 Binding of anti - Factor Bb Monocionals to Factor Bb --s-- -A- (57) : The present disclosure provides anti-complement factor Bb an- tibodies, and compositions comprising the antibodies. The anti-Bb antibodies are useful for treating complement-me- M4 diated disorders. The present disclosure Imo provides methods of treating comple- i.o • -'- M12 ment-mediated disorders. --*--. M17 0.9 • -0- M18 0.8 c 0.7 • -Am- • M20 V) 0.6 ct n 0 0.5 0 0.4 0.3 0.2 0.1 * * • 0.0 1-1 43 42 41 -10 -9 log [rnAb] M Il ir) `o IN ,—, 1. 1 IN ,—, © ei O WO 2017/176651 Al MIDEDIM111101111111111111111111111111111111111111111111111111111111111110111111111111 TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). DE, LT, SE, GA, — before the expiration of the time limit for amending claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) the Published: — with international search report (Art. 21(3))