baber/WOPTO huggingface dataset:
Patent CA-2512867-A1 (CA)
Title: Vitamin receptor binding drug delivery conjugates
Inventor: VLAHOV IONTCHO RADOSLAVOV
IPC: C07K16/46
Filed: 2004-01-27
Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety is a vitamin, or a vitamin receptor binding analog or a derivative thereof, and the drug includes analogs or derivatives thereof.  The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) comprises one or more spacer linkers, releasable linkers, and heteroatom linkers. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.
Patent CA-2513663-A1 (CA)
Inventor: ROBERS BRUCE A
IPC: A45D8/22
Filed: 2004-01-23
Abstract: Novel hair holding devices having first and second pivotally connected body members including hair gripping portions, and methods for improving existing such hair holding devices, in which the improvement involves providing the lust and second body members with at least one elastomeric member (136) for biasing the first and second body members into a closed position and for conforming to gathered strands of user's hair when the hair gripping portions come into contact with gathered strands of a user's hair.
Patent CA-2514804-A1 (CA)
Inventor: HOWARD ALAN NORMAN
IPC: A23L21/25
Filed: 2004-02-20
Abstract: A composition for human consumption, comprising creatine and creatinine, the latter being in sufficient quantity to render creatine in an aqueous medium substantially stable, and a methyl xanthine; and a method of making the composition is provided.
Patent CA-2514912-A1 (CA)
Title: Rnai targeting of viruses
Inventor: KOWALIK TIMOTHY F
IPC: A61K48/00
Filed: 2004-02-05
Abstract: The invention relates to methods and compositions that inhibit viral replication, e.g., CMV replication, within a host or host cell. Methods and compositions of the invention utilize RNA interference to block the translation of mRNA into proteins which are important or essential to viral replication. The method and compositions can be used to study CMV infection in in vitro cell culture and to treat CMV infection in non-human primates and human subjects.
Patent CA-2515073-A1 (CA)
Title: Site equipment survey tool
Inventor: MCCONNELL ROBERT S
IPC: G06Q10/10
Filed: 2004-02-03
Abstract: A method for surveying equipment assets located at a site or at multiple distributed sites. The method can include gathering and compiling any legacy data relating to equipment at a site. Based on this legacy data and the goals and objectives of the enterprise, an equipment asset data structure is created and the legacy data is converted into this structure. This data structure, including the legacy data, is then communicated to a mobile survey device. An operator then uses the mobile survey device to survey the equipment assets located at a site.
Patent CA-2516340-A1 (CA)
Inventor: KECHAGIA PERSEFONI
IPC: B01L99/00
Filed: 2004-06-23
Abstract: This invention provides methods and systems for flushing, washing, and priming microscale devices for reuse. Washing and priming methods include flowing solutions from a manifold to flush wells and microchannels of a microfluidic chip. Systems include manifolds adapted to seal and flow solutions or gasses into chip wells. Devices include microfluidic devices with data storage modules to track the reprocessing status of the microscale devices.
Patent CA-2516344-A1 (CA)
Inventor: CHANG CHAWN-SHANG
IPC: A61K/
Filed: 2004-02-13
Abstract: Disclosed are compositions and methods related to TR2, TR4, androgen receptor, and estrogen receptor, and TRA16 and the interactions between these proteins.
Patent CA-2516682-A1 (CA)
Title: Imidazol-4-yl-ethynyl-pyridine derivatives
Inventor: VIEIRA ERIC
IPC: C07D/
Filed: 2004-03-05
Abstract: 4-[1-Aryl-imidazol-4-ylethynyl]-2-alkyl-pyridine and 1-heteroaryl-imidazol-4-ylethynyl]-2-alkyl-pyridine derivatives and pharmaceutically acceptable salts thereof for the treatment or prevention of disorders mediated full or in part by metabotropic glutamate receptor 5, e.g. acute, traumatic and chronic degenerative processes of the nervous system, such as Alzheimer's disease, senile dementia, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis and multiple sclerosis, psychiatric diseases such as schizophrenia and anxiety, depression, pain and drug dependency.
Patent CA-2517696-A1 (CA)
Title: Device for fixing a wire on a load bearing element provided with at least two openings
Inventor: QUERTELET STEPHANE
IPC: H02G3/38
Filed: 2004-03-03
Abstract: The fixation device has an elastic plate with a body cut and folded in the form of U comprising a core (33) and two wings (34). The wings have an end in the form of T that has an arm adapted to support on a face of a carrier unit opposed to a plain surface at an edge of an opening. The wings have a transversal bar (35) with an inclined wall (36) facilitating its introduction in to the opening. An independent claim is also included for a fuse holder for a cable.
Patent CA-2520068-A1 (CA)
Title: Internal combustion engine for small-sized planing boat
Inventor: HOI YOSUKE
IPC: F16F15/26
Filed: 2005-09-06
Abstract: To provide an internal combustion engine for a small-sized planing boat in which a part that enlarges the internal combustion engine by a balancer shaft is inhibited in a possibly small range and the internal combustion engine is made compact. The invention is characterized in that balancer shafts for preventing secondary vibration are arranged together with a crankshaft on a dividing plane of a crankcase and a cylinder block of an internal combustion engine mutually in parallel, a crankshaft bearing by which the crankshaft is held so that the crankshaft can be rotated is formed in the crankcase and the cylinder block on a dividing plane of plural mutually opposite ribs planted in a longitudinal direction, a balancer shaft bearing by which the balancer shafts are held so that the balancer shafts can be rotated is formed on a dividing plane of a selected longitudinal pair of ribs of the plural ribs in the longitudinal direction and the balancer shaft bearing is biased in a direction in which the balancer shaft bearing approaches the other rib in at least one rib of the longitudinal pair of ribs, compared with the crankshaft bearing.
Patent CA-2520938-A1 (CA)
Title: Paint tray
Inventor: POHL NORMAN R
IPC: B44D3/12
Filed: 2005-09-26
Abstract: A paint tray has side walls with hook-shaped extensions which are engageable with a rung of a ladder to enable the paint tray to be hung therefrom. The side walls also have wall-like extensions adjacent the opposite end. The base has an extension extending between the wall-like extensions and having a reversely bent portion to form a paint reservoir when the paint tray is upright. The wall-like extensions have hook-shaped portions adjacent the upper front edge of the paint reservoir which are engageable with a rung of a ladder with the paint reservoir behind the rung when the hook-shaped extensions are engaged with a higher rung.
Patent CA-2521459-A1 (CA)
Title: Apparatus and methods for reducing stand-off effects of a downhole tool
Inventor: SMITS JAN W
IPC: E21B47/12
Filed: 2005-09-27
Abstract: A method for reducing stand-off effects of a downhole tool includes disposing the downhole tool in a borehole, wherein the downhole tool comprises at least one moveable section disposed between an energy source and a receiver on the downhole tool; and activating the at least one moveable section to reduce a thickness of at least one selected from a mud layer and a mudcake between the downhole tool and a wall of the borehole. A downhole tool includes an energy source and a receiver disposed on the downhole tool; at least one moveable section disposed between the energy source and the receiver; and an activation mechanism for reducing a thickness of at least one selected from a mud layer and a mudcake between the downhole tool and a wall of a borehole.
Patent CA-2524261-A1 (CA)
Inventor: CHOI YOUNG HO
IPC: G01N33/558
Filed: 2004-05-03
Abstract: The present application discloses an analyte detection apparatus (Figures 1, 2, 3) having at least one reservoir area and a wicking membrane, wherein a labeled specific binding partner is impregnated on the reservoir area; and a region on the wicking membrane where at least one chemical component is immobilized.
Patent CA-2525625-A1 (CA)
Inventor: RASSADI MARJAN
IPC: C22B5/20
Filed: 2005-11-07
Abstract: A process for the production of pure metallic nickel and cobalt from metallic ores comprising oxides of nickel, cobalt and iron, the process comprising (a) treating the ores with hydrogen at a pressure of at least atmospheric pressure and an effective temperature, in the presence of chloride anion or an in situ generator thereof precursor; to produce a first mixture comprising particulate nickel and particulate cobalt; (b) reacting the first mixture with carbon monoxide to produce gaseous nickel carbonyl and a first residue comprising solid cobalt carbonyl; (c) removing and thermally decomposing the nickel carbonyl to produce the pure metallic nickel; (d) treating the first residue with an effective amount of a complexing gaseous mixture of nitric oxide and carbon monoxide to produce cobalt nitrosyl tricarbonyl;  and removing and decomposing the cobalt nitrosyl tricarbonyl to provide the purified cobalt and regenerated complexing gaseous mixture; and removing the regenerated complexing gaseous mixture.
Patent CA-2526297-A1 (CA)
Title: Bladder wall thickness measurement system and methods
Inventor: DUDYCHA STEPHEN
IPC: G06T5/00
Filed: 2003-05-09
Abstract: An ultrasound transceiver (10) scans a bladder in a three dimensional array to measure the thickness and surface area ot the bladder to determine bladder mass. The bladder wall thickness and the masses may be determined for anterior, posterior, and lateral locations of the bladder.
Patent CA-2527254-A1 (CA)
Title: Composition for the protection of glassware in a dishwashing process
Inventor: HAHN KARLHEINZ ULRICH GERHARD
IPC: C11D3/02
Filed: 2004-05-19
Abstract: The present invention provides a composition. The composition comprises zinc and bismuth. The composition is for use in the protection of glassware in an automatic dishwashing process.
Patent CA-2530126-A1 (CA)
Inventor: TODARO FRANCESCO
IPC: C25B9/19
Filed: 2004-06-23
Abstract: A cell (100) for metal electrowinning from metal ion solutions is described, wherein the cathode (1) consists of a falling bed of growing beads; the beads, withdrawn from the lower part of the bed, are recycled to the top section of the cathodic compartment by means of an external vertical duct (3).
Patent CA-2530979-A1 (CA)
Title: Steroid modified chacotrioses and solatrioses
Inventor: WEYMOUTH-WILSON ALEXANDER CHAR
IPC: C07J71/00
Filed: 2004-07-08
Abstract: The present invention relates to steroid modified chacotrioses and the synthesis thereof as well as to intermediate compounds useful for the synthesis of the steroid modified chacotrioses and solatrioses. Moreover, the present invention relates to a method for the preparation of steroid-modified solatrioses.
Patent CA-2531721-A1 (CA)
Title: Dual drug dosage forms with improved separation of drugs
Inventor: SHELL JOHN N
IPC: A61K9/20
Filed: 2004-07-13
Abstract: Drug tablets that include a prolonged-release core and an immediate-release layer or shell are prepared with a thin barrier layer of drug-free polymer between the prolonged-release and immediate-release portions of the tablet.  The barrier layer is penetrable by gastrointestinal fluid, thereby providing full access of the gastrointestinal fluid to the prolonged-release core, but remains intact during the application of the immediate-release layer, substantially reducing or eliminating any penetration of the immediate-release drug into the prolonged-release portion.
Patent CA-2532588-A1 (CA)
Inventor: SHEN CHUNGSEA
IPC: A23G4/08
Filed: 2004-07-27
Abstract: A chewing gum base essentially free of non-silica fillers, comprising high molecular weight polyisobutylene, optionally amorphous silica and polyvinylacetate and powdered lecithin present in the chewing gum composition and optionally spray-dried flavor in the chewing gum composition.
Patent CA-2533358-A1 (CA)
Title: Antibiotic product, use and formulation thereof
Inventor: ROWLINGS COLIN
IPC: A61K9/22
Filed: 2004-07-20
Abstract: An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more sustained release dosage forms, with each of the dosage forms having a different relea se profile, wherein each reaches a Cmax at different times.
Patent CA-2534325-A1 (CA)
Title: Elastic clamp and syringe pump comprising the clamp
Inventor: KNIGHT BYRON J
IPC: F16L3/12
Filed: 2004-08-24
Abstract: A clamp (100) includes a hoop section and actuating elements (100a, 100b). The hoop section forms a cavity for holding a tubular object (200). The hoop section has first and second ends. First and second actuating elements are respectively coupled with the first and second ends of the hoop section.  Squeezing the ends of the actuating members together causes the hoop section to expand to facilitate installation of the clamp onto an object to be clamped and removal of the clamp from the object. Thus, the clamping force generated by the clamp is limited by the restoring forces inherent in the shape, sized, and material of the hoop section when the actuating members are released. The actuating members include expansion limiting extensions (110a, 110b) which contact each other after a prescribed amount of expansion of the hoop section to thereby prevent further expansion, and possible yielding, of the hoop section. The clamp can be employed as an anti-rotation device secured to a syringe of a syringe pump.
Patent CA-2534530-A1 (CA)
Title: Satiety enhancing food compositions
Inventor: BODOR JANOS
IPC: A23L33/00
Filed: 2004-08-19
Abstract: The present invention provides an aqueous liquid or spoonable edible composition comprising at least 1% wt protein and from 0.1 to 5% wt of a biopolymer thickening agent which is not denatured or hydrolysed between pH 2 and 4, and wherein the composition has a gel strength at 37~C and pH 2 of at least 10 KPa. The compositions of the invention have good satiety effects and are beneficial for use in weight control plans.
Patent CA-2535385-A1 (CA)
Title: Process for the preparation of 4-amino-3-quinolinecarbonitriles
Inventor: BLUM DAVID MICHAEL
IPC: C07D405/04
Filed: 2004-08-13
Abstract: This invention discloses a process for the preparation of a 4-amino-3quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up-to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield an 2-amino-2-cyanoacrylamide; combining the 3-amino2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine~6-carbonitrile comprising combining a 3-amino thiophene with a cyanoacetamide and trial kylorthoformate in an alcoholic solvent to obtain a 3-amino2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4 amino-3-quinolinecarbonitrile comprising: combining an amine compound with cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension; to yield cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline with an alcoholic solvent to yield a 4-amino-3-quinolinecarbonitrile, and the invention discloses a process for obtaining a cyanoacetamide.
Patent CA-2538255-A1 (CA)
Title: Cyanoacrylate monomer formulation containing diiodomethyl-p-tolylsulfone
Inventor: BORDOLOI BINOY K
IPC: A61L24/06
Filed: 2004-08-16
Abstract: A polymerizable antimicrobial formulation for forming a wound closure adhesive comprising cyanoacrylate monomer and diiodomethyl-p-tolylsulfone; and a method for closing the approximated edges of a wound with a polymeric film that substantially inhibits the growth of microorganisms, where the polymeric film is formed by use of the polymerizable antimicrobial formulation.
Patent CA-2539160-A1 (CA)
Title: Antibacterial agents
Inventor: HAGEN SUSAN ELIZABETH
IPC: A61K31/53
Filed: 2004-09-06
Abstract: Compounds of formula (I) and methods for their preparation are disclosed.  Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications, including using the invention compounds to treat bacterial infections. Formula (I).
Patent CA-2539470-A1 (CA)
Title: Systems and methods for dynamically updating software in a protocol gateway
Inventor: PUGH RICHARD S
IPC: G06F/
Filed: 2004-09-13
Abstract: A method for dynamically updating software modules comprises loading a new software module to replace an existing software module. Before the old software module is terminated, however, a check is run to determine if the old software module is engaged in, or being used by, any existing routines, such as an existing communication session. If the old software module is being used, then it can be preserved. Once the old software module is no longer being used, then it can be terminate and all new routines can be configured to use the new software module.
Patent CA-2540691-A1 (CA)
Title: Detecteur d'onde de plaque flexible
Inventor: CUNNINGHAM BRIAN
IPC: G01L9/00
Filed: 2004-09-30
Abstract: L'invention porte sur un détecteur d'onde de plaque flexible comprenant une plaque flexible présentant une certaine longueur et une certaine largeur, ainsi qu'un tracé en peigne sur la plaque flexible, des dents d'entraînement étant disposées le long de toute la longueur de la plaque flexible afin de réduire le nombre de modes propres excités dans la plaque, ce qui permet de simplifier le fonctionnement et la conception du détecteur d'onde de plaque flexible.
Patent CA-2540863-A1 (CA)
Inventor: TRAN FRANK
IPC: C03C25/10
Filed: 2004-10-01
Abstract: A photocurable composition comprising cationically curable compound, an acrylate- containing compound; a hydroxyl- containing compound; a cationic photoinitiator; and a free radical photoinitiator; wherein said composition has less than 0.54 equivalents of cationically curable groups, less than 0.10 equivalents of acrylate groups and less than 0.10 equivalents of hydroxyl 0groups per 100 grams of said composition.
Patent CA-2542292-A1 (CA)
Inventor: KIM TAE-KON
IPC: A23L1/30
Filed: 2004-10-11
Abstract: The present invention relates to the triterpene compounds improving in brain functions. In particular, the present invention relates to a novel use of the triterpene compounds represented by the Formula 1 for improving decreased memory and a pharmaceutical composition for improving brain functions comprising the triterpene compounds represented by the Formula 1.
Patent CA-2543458-A1 (CA)
Title: Process for co-spray drying agents with dry silicified mcc
Inventor: ZELEZNIK JOSEPH A
IPC: A61K9/48
Filed: 2004-10-21
Abstract: A process for preparing agglomerated particles comprising a) providing an active agent (1) in a from suitable for spray drying and b) combining the active agent with dry silicified microcrystalline cellulose (4) in a dryer to form agglomerated particles (5).
Patent CA-2546397-A1 (CA)
Inventor: WAHAB NADIA ABDEL
IPC: G01N33/50
Filed: 2004-11-12
Abstract: The invention provides a method for identifying and/or making compounds for use in reducing and/or preventing fibrosis, comprising the steps: providing a cell type capable of expressing TIEG and/or Smad-7; providing a test compound;  providing an amount of CTGF or a functional equivalent thereof, exposing the cell type to the test compound; subsequently or simultaneously exposing the cell type to the CTGF or functional equivalent thereof; detecting and/or measuring the expression of Smad-7 and TIEG; and comparing the amount of Smad-7 and/or TIEG expressed in the presence of the test compound with the amount of Smad-7 and/or TIEG produced detected and/or measured in the absence of a test compound; determining if a compound reduces and/or prevents fibrosis on the basis that it causes no change or an increase in Smad-7 expression and/or no change or a decrease in TIEG expression. There is also provided compounds for reducing and/or preventing fibrosis and uses of such compounds.
Patent CA-2546565-A1 (CA)
Title: Pharmaceutical composition comprising a beta-3-adrenoceptor agonist and an agent intervening in the prostaglandin metabolism
Inventor: WIENRICH MARION
IPC: A61K31/24
Filed: 2004-11-13
Abstract: The invention relates to a novel combination for the treatment of functional bladder disorders, comprising a beta-3-adrenoceptor agonist and an agent that intervenes in the prostaglandin metabolism.
Patent CA-2548418-A1 (CA)
Title: A convertible dispenser for sheet material
Inventor: WELCHEL DEBRA N
IPC: A47K10/42
Filed: 2004-08-30
Abstract: A dispenser is provided which is adapted for dispensing from a table top and it is convertible to dispense from a conventional rolled product fixture. The dispenser includes a housing having a compartment configured to hold sheets.  The housing also has a dispensing opening. The housing is configured to be positioned on a table top for dispensing sheets therefrom, and the housing includes a hanging port which permits the housing to be coupled to a conventional rolled product fixture. The hanging port is masked when the dispenser is positioned for dispensing from a table top. The hanging port is easily unmasked and configured to releasably couple the housing to a fixture in a bathroom for dispensing sheets therefrom.
Patent CA-2549099-A1 (CA)
Title: Integrated system for controlling lights and shades
Inventor: BAMBERGER MATTHEW
IPC: H04L12/28
Filed: 2004-12-10
Abstract: A control system includes a processor transmitting signals to a shade network and a lighting system directing that motorized shades and dimmable loads be set to desired intensity levels. A communication interface having a buffer is connected between the processor and the shade network. The communication interface provides for communication with the processor based on streaming protocol and with the shade network based on event-based protocol. The shade network converts intensity levels into shade positions. The processor may direct the shade network to move a shade in a series of substantially equal steps to simulate a relatively slowly moving shade. The processor may be connected to a timing device for creating a program based on time-based shade position information for directing the shades to be moved to given positions at certain times of day. A computer running user interface software may be be connected to the system to facilitate programming.