Patent SG-11201807778Y-A (SG)
Title: Bicyclic compounds for diagnosis and therapy
Inventor: MOLETTE JÉRÔME
IPC: A61K31/4439
Filed: 2017-03-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111101100110011111011111101111011111 International Bureau .. .... ..Yejd .... ...,,, (10) International Publication Number (43) International Publication Date WO 2017/153601 Al 14 September 2017 (14.09.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every CO7D 417/14 (2006.01) A61K 31/4365 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 495/04 (2006.01) A61K 31/4439 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07D 513/04 (2006.01) A61P 25/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 31/4427 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/EP2017/055754 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 10 March 2017 (10.03.2017) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 16159878.4 11 March 2016 (11.03.2016) EP GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 16199577.4 18 November 2016 (18.11.2016) EP TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicant: AC IMMUNE SA [CH/CH]; EPFL Innovation DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Park, Building B, 1015 Lausanne (CH). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: MOLETTE, Jerome; 37, La Ruelle Bretigny, 01280 Prevessin Moens (FR). GABELLIERI, Emanuele; SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Avenue du parc de la Rouvraie 10, 1018 Lausanne (CH). Published: — with international search report (Art. 21(3)) DARMENCY, Vincent; Chemin du Creux du Chable 1, 1072 Bougy-Villars (CH). — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of Agent: PARTNER (74) VOSSIUS & (NO 31); SiebertstraBe 3, 81675 Miinchen (DE). amendments (Rule 48.2(h)) (54) Title: BICYCLIC COMPOUNDS FOR DIAGNOSIS AND THERAPY ,-1 Y ..------.. --- A '-, - ICI ,-, u .....z © 7 wi „..- rD -....., .----_, en x (I) - K,,,,! . : ir) Il ---. (57) : The present invention relates to the compounds of formula (I) that can be employed in the diagnosis, monitoring of IN disease progression or monitoring of drug activity, of a group of disorders and abnormalities associated with alpha-synuclein (a-sy - I-1 nuclein, A- synuciein, aSynuciein, A-syn, a-syn, aSyn) aggregates including, but not limited to, Lewy bodies and/or Lewy neurites, ei such as Parkinson's disease. The instant compounds are particularly useful in determining a predisposition to such a disorder, monit - O oring residual disorder, or predicting the responsiveness of a patient who is suffering from such a disorder to the treatment with a certain medicament. The present compounds can also be used to treat, alleviate or prevent a disorder or abnormality associated with alpha-synuclein aggregates.