baber/WOPTO huggingface dataset:
Patent DE-60328195-D1 (DE)
Inventor: GREENFEDER SCOTT
IPC: A61P37/06
Filed: 2003-03-27
Granted: 2009-08-13
Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to interleukin 5 (IL-5), which is preferably human IL-5. The invention also relates to human anti-IL-5 antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IL-5 antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IL-5 antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IL-5 antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
Patent DE-60328577-D1 (DE)
Inventor: MICHAUD HERVE
IPC: C22C38/60
Filed: 2003-12-01
Granted: 2009-09-10
Abstract: The fabrication of a forged steel component comprises: (a) producing and casting a steel of given composition; (b) forging a blank of the component at a temperature of 1100 to 1300 degreesC; (c) effecting a controlled cooling of the blank in still or pulsed air; (d) machining the component; (e) effecting an operation of mechanical reinforcement of the component to the needs to which it will be subjected.
Patent DE-60334253-D1 (DE)
Inventor: ZHU ALAN QING-LIN
IPC: E04H17/16
Filed: 2003-12-19
Granted: 2010-10-28
Abstract: A modular picket fence including a pair of vertical posts positioned at suitable distance and adapted to be secured to a suitable support surface. A pair of horizontal upper and lower rails extend between and secured to the vertical posts. The upper rail has a plurality of apertures which are aligned with a plurality of apertures on the lower rail. The apertures can be of any given shape including square, narrow rectangular, wide rectangular, oval, round, narrow polygonal and wide polygonal. A plurality of vertical pickets having a cross-sectional shape corresponding to the shape of the apertures in the horizontal rails are respectively inserted through into aligned apertures of the upper and lower rails. The end portion of each vertical picket has two transverse apertures.
Patent DE-60334507-D1 (DE)
Inventor: ZHAO LIJUN
IPC: H04W36/14
Filed: 2003-04-09
Granted: 2010-11-18
Abstract: Techniques for supporting handoff of a terminal between base stations of different protocol revisions (P REVs) in a CDMA system. The terminal is handed off from a first base station (with a first P REV) to a second base station (with a second P REV) while it is in an active (data or voice) call with the first base station. The second P REV is later than the first P REV. The active call may be maintained between the terminal and second base station using a first service configuration previously established via the first base station for the active call. A second service configuration may be established via the second base station for the active call. This may be achieved by (1) querying the terminal, (2) assignment by the second base station, or (3) initiation by the terminal. The active call may then be maintained using the second service configuration if available.
Patent DE-68904022-D1 (DE)
Inventor: GONCALVES ANTONIN
IPC: B65D83/38
Filed: 1989-08-04
Granted: 1993-02-04
Abstract: The invention relates to a device for fixation of valve (3) to a container (1); in this device, an annular collar (4) covers the flange (33) of the valve and assures the clamping of the valve gasket (7) by locking to the bead (23) of the container. A ring (5) surrounds the collar (4) and is screwed onto it, to prevent unlocking of the collar (4) under the influence of the internal pressure of the container.
Patent DE-68910773-D1 (DE)
Inventor: KOYAMA HIROYOSHI
IPC: A61K9/16
Filed: 1989-09-26
Granted: 1993-12-23
Abstract: Granules having a core are produced by spraying core granules with a dispersion of a low substituted hydorxypropylcellulose (L-HPC), and, if necessary, simultaneously applying a dusting powder. The granules having a core thus obtained exhibit increased granule strength and improved disintegrating property as compared with those produced by known methods. An active ingredient such as a drug can be contained in the dispersion, dusting powder or core granules.
Patent DE-68914345-D1 (DE)
Inventor: IMURA HIROO
IPC: C12P21/00
Filed: 1989-06-30
Granted: 1994-05-11
Abstract: Monoclonal antibodies which recognize the N-terminal of gamma-atrial natriuretic polypeptide ( gamma -ANP). Hybridomas capable of producing said monoclonal antibodies, including methods for their production, and the use of such antibodies in an immunoasssay for gamma -ANP.
Patent DE-68916439-D1 (DE)
Inventor: SCHMIDT PAUL
IPC: A61K47/42
Filed: 1989-10-03
Granted: 1994-07-28
Abstract: A composition and method are provided for the making of cholesterol containing phospholipid liposomes such that when dried and then reconstituted, the liposomes retain their structure and size distribution as well as substantially all of the material that was originally encapsulated, and they behave biologically in a normal fashion. The cryoprotective agents are used in the aqueous medium to hydrate the phospholipid(s) and are a combination of at least one sugar and at least one protein, polypeptide, and/or oligopeptide.
Patent DE-68919347-D1 (DE)
Inventor: OKUSA NAOYA
IPC: C12Q1/52
Filed: 1989-02-17
Granted: 1994-12-15
Abstract: A method for measuring degree of freshness and measuring kit for the method are disclosed. The method involves (i) a step of neutralizing a specimen containing ATP-related compounds, (ii) a step of subjecting a definite amount of the specimen having been neutralized in step (i) to an enzyme capable of decomposing ATP-related compounds into hydrogen peroxide and uric acid, and bringing the reaction solution into contact with a testing piece impregnated with N-ethyl-N-sulfobutyl-m-toluidine to color the testing piece, (iii) a step of subjecting a definite amount of the specimen having been neutralized in step (i) to an enzyme capable of decomposing inosine and hypoxanthine into hydrogen peroxide and uric acid, and bringing the reaction solution into contact with a testing piece impregnated with N-ethyl-N-sulfobutyl-m-toluidine, and (iv) a step of comparing the coloration of testing piece in step (ii) with coloration of testing piece in step (iii). This method enables to easily and rapidly measure degree of freshness of fishery products and meats without large-sized equipment.
Patent DE-68921241-D1 (DE)
Inventor: JAKUBICKI GARY J
IPC: C11D3/37
Filed: 1989-05-09
Granted: 1995-03-30
Abstract: A non-scratching household cleaning composition containing as a major ingredient poly[alpha-methyl-styrene-styrene-acrylonitrile] commercially available as "BLENDEX 586". This ingredient is blended with a conventional surfactant and builder. The system can also contain a solvent or bleach system. The BLENDEX 586 component is present as finely divided particles having a size range of about 44-to-420 microns.
Patent DE-68921754-D1 (DE)
Inventor: SUDRE PAUL
IPC: D21F1/00
Filed: 1989-06-16
Granted: 1995-04-20
Abstract: A method for the manufacture of a papermaker's fabric is proposed which involves the provision of a multiply fabric having fold regions (15, 16) at its respective ends and the removal of cross-machine direction yarns (14) in such fold regions thereby to create seam-forming loops (17, 18). The loops (17, 18) may be interdigitated directly to receive a pintle wire into engagement therewith and thus form a seam, or may receive a spiral for seam-forming purposes. The method is of application to flat-woven or endless woven structures, and is of use in the manufacture not only of papermaker's fabrics per se but also in the manufacture of base materials for use therein.
Patent DE-68922614-D1 (DE)
Inventor: GEWIRTZ ALAN
IPC: C07K14/82
Filed: 1989-11-03
Granted: 1995-06-14
Abstract: Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the human c-myb gene. These "antisense" oligonucleotides are hybridizable to the c-myb mRNA transcript. Such oligonucleotides are useful in treating hematologic neoplasms and in inducing immunosuppression. They are particularly useful as bone marrow purging agents.
Patent DE-69001154-D1 (DE)
Inventor: COMMANDEUR RAYMOND
IPC: C07C22/04
Filed: 1990-06-01
Granted: 1993-04-29
Abstract: Separation of two isomers, characterised (i) in that one of them is condensed selectively with a product containing at least one aryl hydrogen and in the presence of a Friedel and Crafts catalyst, (ii) the product of condensation obtained is then separated from the other isomer. In a mixture of 1-phenyl-2-bromoethane and 1-phenyl-1-bromoethane the latter alone condenses with xylene in the presence of ferric chloride to yield phenylxylylethane.
Patent DE-69013476-D1 (DE)
Inventor: NOZULAK JOACHIM
IPC: C07D265/34
Filed: 1990-12-11
Granted: 1994-11-24
Abstract: Compounds of formula I <IMAGE> wherein R1, R2, R3 and R4 are as defined in the description, are useful for the treatment of conditions associated with cerebral is schaemia, e.g. stroke.
Patent DE-69015759-D1 (DE)
Inventor: LE BIHAN DENIS
IPC: H04L12/54
Filed: 1990-10-08
Granted: 1995-02-16
Abstract: The incoming cells of a input asynchronous time-division multiplex channel (mtr) are counted by a counter (FFB) assigned to each virtual circuit which is incremented on each incoming cell of the virtual circuit and decremented periodically. Clock signals define consecutively numbered cell times (ntc). Queue and chaining table (FAVE, FCVN) define a cell time queue (FAF, FAL, FAV) specific to each of the cell times, a virtual circuit being assignable to a cell time by writing its identifier into the corresponding cell time queue. A controller (MC) uses the content of the cell time queues (FAF, FAL, FAV) and, for each cell time, identifies a virtual circuit to be processed and decrements the counter (FFB) belonging to this virtual circuit. The controller further includes arrangements whereby any virtual circuit whose counter is not idle is assigned to one of the cell times to be decremented by virtue of the arrival of this cell time.
Patent DE-69016198-D1 (DE)
Inventor: BARET GILLES
IPC: G01M3/20
Filed: 1990-07-06
Granted: 1995-03-02
Abstract: Second stage mechanical vacuum pumping unit (20) comprising two pumping stages, the first stage having an intake inlet (9) the second stage having an inlet orifice (10), the said inlet and the said orifice both ending on the outside, the two stages having a common delivery outlet (4), characterised in that the two said pumping stages are of the Holweck drum type, the said first stage having a compression ratio of the order of 50 for a gas such as helium, and of the order of 30,000 for air, the pumping speed of the said first stage being of the order of 4 l/sec for air and of the order of 2.5 l/sec for the said gas, and in that the said second stage has a pumping speed of the order of 3.5 l/sec for air and of the order of 2 l/sec for the said gas, the nominal speed of rotation of the said mechanical pumping unit being of the order of 27,000 rpm. <IMAGE>
Patent DE-69016410-D1 (DE)
Inventor: DETRONDE MICHEL
IPC: B23Q7/16
Filed: 1990-06-01
Granted: 1995-03-09
Abstract: Apparatus and a method for removing surface defects from elongate metal billets (1) arranged in side-by-side relation, comprises a support framework (3,4,5,6) carrying a grinding wheel assembly (7), the support framework being adapted to move the grinding wheel (7) in three mutually orthogonal directions. <IMAGE>
Patent DE-69017684-D1 (DE)
Inventor: VANEENAM DONALD
IPC: C11D3/43
Filed: 1990-06-12
Granted: 1995-04-13
Abstract: Improved stable, aqueous cleaner/degreaser compositions formulated in the form of totally water soluble solutions comprise: (a) at least one sparingly water soluble organic solvent characterized by: (i) having a watersolubility in the range of approximately 0.2 to approximately 6 weight percent; (ii) not being a hydrocarbon or halocarbon; (iii) having one or more similar or dissimilar oxygen, nitrogen, sulfur or phosphorous containing functional groups; (iv) being a solvent for hydrophobic soilants; and (v) being present in an amount exceeding its aqueous solubility; (b) a solubilizing additive consisting of from approximately 0.1 to approximately 100 weight percent of a surfactant and from 0 to approximately 99.9 weight percent of a coupler, the solubilizing additive being present in an amount not exceeding approximately tenfold that required to completely solubilize the organic solvent; and (c) water. Such compositions exhibit markedly superior cleaning/degreasing efficacy over that achievable with compositions containing infinitely water soluble organic solvents such as butyl cellosolve.
Patent DE-69027505-D1 (DE)
Inventor: IMPERIAL GEORGE
IPC: D21H19/16
Filed: 1990-10-16
Granted: 1996-07-25
Abstract: A paper useful in ion deposition printing. The paper comprises a base sheet or web (30) to which there is applied a coating of a material selected from a group that is at least partially soluble with the binders of the toner employed in the printing process under the conditions of pressure and temperature at which such toner is transferred to the paper in the course of such printing.
Patent DE-69028283-D1 (DE)
Inventor: FISCHELL ROBERT E
IPC: A61B17/32
Filed: 1990-10-26
Granted: 1996-10-02
Abstract: An excision catheter comprises a cylindrical cutting head (22) with a rearwardly directed cutting edge (24). The catheter has a flexible nose (36) enabling the catheter to be fed into an artery over a pre-inserted guide wire which passes through the lumen (32) of the catheter. During insertion, the cutting edge (24) is shielded by the distal end (58) of an outer sleeve catheter (52). Following insertion, the sleeve (52) can be retracted to expose the cutting edge (24) of the cutting head (22). The cutting head is then pulled back through the obstructive tissue which accumulates in the tissue collection chamber (28) inside the cutting head (22). Prior to withdrawal, the open end of the cutting head can once again be sealed by retraction against the tip (58) of the outer sleeve (52), thus trapping the excised tissue in the chamber (28) for removal of that tissue from the body. Preferably means are provided for rotating the cutting head during the excision. <IMAGE>
Patent DE-69107250-D1 (DE)
Inventor: DEBAERT MICHEL
IPC: C07D233/54
Filed: 1991-06-27
Granted: 1995-03-23
Abstract: Compounds of formula (I): 
<IMAGE>
 in which:
 R1 represents a hydroxyl, amino, alkylamino or alkoxy group or a halogen atom,
 R2 represents a hydrogen atom, an alkyl radical, an acyl radical or an alkoxycarbonyl radical,
 R represents:
 a radical of formula: 
<IMAGE>
 in which:
 X represents an oxygen or sulphur atom or an NH group,
 Y represents a carbon, oxygen or nitrogen atom,
 a radical of formula:
 in which
 Z represents an oxygen or sulphur atom or an NH group,
 T represents a carbon or nitrogen atom,
 a cycloalkyl, cycloalkylalkyl or dicycloalkylalkyl radical optionally substituted on the ring,
 an aromatic radical, optionally substituted and including 2 or 3 nitrogen atoms in its carbon skeleton,
 an aromatic radical including from 1 to 3 nitrogen atoms in its carbon skeleton and fused to a benzene ring, it being possible for each of these 2 rings to be optionally substituted,
 or a saturated or unsaturated seven-membered ring including one or two nitrogen atoms in its carbon skeleton, optionally fused to a benzene ring and optionally substituted on the nitrogen-containing and/or benzene ring,
 possess antagonist activity with respect to GABAB.
Patent DE-69114326-D1 (DE)
Inventor: SCHMIDT HARALD HANS
IPC: B29C45/27
Filed: 1991-02-08
Granted: 1995-12-14
Abstract: An injection molding heated manifold (12) having a melt passage (64) with a longitudinal portion (74) to convey melt from a molding machine to a number of different nozzles (10). The steel manifold (12) has a pair of cooling bores (70,72) extending parallel to and equally spaced on opposite sides of the longitudinal portion (74) of the melt channel (64). A cooling fluid, such as air, flows through the cooling bores (70,72) to quickly cool the manifold after the system is shut down to minimize deterioration of the melt in the melt channel (64). The air flows helically around spiral vanes (84) which are mounted in the cooling bores (70,72) to avoid temperature stratification along the melt passage (64). <IMAGE>
Patent DE-69115570-D1 (DE)
Inventor: MONGELLI NICOLA
IPC: A61K31/40
Filed: 1991-01-07
Granted: 1996-02-01
Abstract: The invention relates to ureido derivatives of substituted pyrroles of formula    <IMAGE>  (I)  wherein each of m and n, being the same, is an integer of 1 to 3; W is oxygen of sulphur; each of the B groups, which are the same, is a) a saturated or unsaturated, carbocyclic or condensed carbocyclic ring substituted by one or more acid groups; b) a saturated or unsaturated, heteromonocyclic or heterobicyclic ring, containing one or more heteroatoms chosen from nitrogen, oxygen and sulphur, substituted by one or more acid groups; c) a pyranyl or furanyl sugar residue substituted by one or more acid groups; or d) a -CH2(CHA)rCH2A group, wherein each A group, being the same or different, is an acid group and r is 0, 1 or 2; and the pharmaceutically acceptable salts thereof, which are useful as angiogenesis inhibitors.
Patent DE-69126534-D1 (DE)
Inventor: MORISAWA YASUHIRO
IPC: C07H19/01
Filed: 1991-03-01
Granted: 1997-07-17
Abstract: Milbemycin ether derivs. of formula (I), and their salts and esters, are new. R1 is 4-8C cycloalkyl, R (substd. by 3-8C cycloalkyl which is itself opt. subtd. by Q) or a gp. of formula (i): R2 is e.g H, halo, CN, NO2, R (opt. substd. by Q') RO, 2-6C alkoxyalkyl, TH, TCOR4, TCOCOR4, TCHR6NHCOR6 etc.; T is (CH2)nNR9 (bonded to the ring via C); n is 0, 1 or 2; m is 1 or 2; each R6 is e.g, H, A (opt. substd. by Q''), 2-8C aliphatic hydrocarbyl (contg. one or two double or triple bonds), 3-8C cycloalkyl (opt. subtd. by Q), or 6-14C aryl, or NR6R6 is a 3-7 membered heterocycle (opt. contg. 1 other O, S or N heteroatom); or NR6NR6 is a 3-7 membered heterocycle (opt. contg. 1 other O, S or N hetroatoms, R is R, 3-7C cycloalkyl, or R(substd. by 1-3 6-10C aryl which ar themselves opt. substd. by Q); R9 is H or R; R is 1-4 alkyl; A is 1-8C alkyl; V is CH2, CH2CH2 or OCH2; R5 is Me, Et, iPr or sec-Bu; X is OH, 1-5C alkenoyloxy (opt. substd. by Q''') or hydroxyimino; Q is e.g, halo, RO, R, RS, 1-5C alkanoyloxy, ROCO, CN, NO2, NHR, N(R)2, CONH2 etc.; Q is halo, RO, RS or 1-5C alkaneyloxy; Q'' is e.g, 3-8C cycloalkyl, RO, RS, 2-5C cyanoalkylthio, ROCO, halo, CN, NO2, NH2 etc.; Q''' is halo, RO, ROCO or COOH.
Patent DE-69128367-D1 (DE)
Inventor: MOHAN CHANDRASEKARAN
IPC: G06F9/46
Filed: 1991-02-13
Granted: 1998-01-22
Abstract: Apparatus and method for reading data pages 33 in a transaction processing system 20 without locking the pages are disclosed. The system maintains a Global_Committed_LSN 36 identifying the oldest uncommitted transaction accessing any of the data, and Object_Committed_LSNs 38a,38b identifying the oldest uncommitted transactions accessing particular files, tables and indexes. Each data page includes a Page_LSN 35 identifying the last transaction to have updated the page. To read a page, a transaction first latches the pages, and compares the page s Page_LSN with the Global_Committed_LSN, or with the page's respective Object_Committed_LSN. If the Page_LSN is older than the Committed_LSN with which is was compared, then the transaction reads the page without locking it, since there can be no uncommitted transaction in process which might have updated the page's data. However if the Page_LSN is younger than the Committed_LSN, the page is locked before being read. <IMAGE>
Patent DE-69129988-D1 (DE)
Inventor: SVENDSEN ALLAN
IPC: C12N1/15
Filed: 1991-09-13
Granted: 1998-09-17
Abstract: Lipases comprising a trypsin-like catalytic triad including an active serine located in a predominantly hydrophobic, elongated binding pocket of the lipase molecule, which pocket forms part of and is surrounded by a lipid contact zone, are mutated by deletion or substitution of one or more amino acid residues in the lipid contact zone so as to change the electrostatic charge and/or hydrophobicity of the lipid contact zone or so as to change the surface conformation of the lipid contact zone of the lipases.
Patent DE-69130613-D1 (DE)
Inventor: INSTANCE DAVID JOHN
IPC: B31D1/02
Filed: 1991-08-30
Granted: 1999-01-21
Abstract: A self-adhesive label (10) comprising a multilaminar folded label (8) which comprises first (12) and second portions (14) which are adhered to a backing of release material (2) or to a self-adhesive support piece carried on a backing of release material by a first region (4) of permanent adhesive and a second region (6) of resealable adhesive respectively.
Patent DE-69202390-D1 (DE)
Inventor: LE LIEVRE PATRICK
IPC: B60J10/82
Filed: 1992-03-26
Granted: 1995-06-14
Abstract: The invention relates to an encapsulated glazing 1, 12, in particular for a sunroof. This glazing comprises a transparent, monolithic or laminated substrate 4, 13 surrounded on at least part of its periphery, by a reinforced plastic material 5, 14 obtained by encapsulation of the substrate. This plastic material is, according to the invention, based on a low shrinkage resin reinforced by reinforcement fibres and it has a flexural strength greater than 7000 MPa and, preferably, greater than 10000 MPa. <IMAGE>
Patent DE-69204786-D1 (DE)
Inventor: MELLUL MYRIAM
IPC: A61K8/89
Filed: 1992-07-24
Granted: 1995-10-19
Abstract: Colourless or coloured nail varnish, containing, in a solvent system for varnish, as a film-forming substance, nitrocellulose, an arylsulphonamide-formaldehyde resin or an alkyd resin and a plasticising agent, as well as an aminosilicone in a proportion of between 0.05 and 5% by weight.
Patent DE-69211706-D1 (DE)
Inventor: SMITH ALBERT H
IPC: B41M5/132
Filed: 1992-10-22
Granted: 1996-07-25
Abstract: A thermosensitive recording element comprising a support having a Sheffield smoothness of less than 60, and at least one layer provided thereon wherein said layer comprises an organic polymeric binder, a substantially colorless electron donating dye precursor and an electron accepting compound capable of forming color by reacting with said dye precursor, wherein the binder, the electron accepting compound and the dye precursor have a particle size of less than about 3 mu .
Patent DE-69211810-D1 (DE)
Inventor: GILLIOZ MARC
IPC: A44B19/26
Filed: 1992-04-29
Granted: 1996-08-01
Abstract: PCT No. PCT/CH92/00086 Sec. 371 Date Dec. 22, 1992 Sec. 102(e) Date Dec. 22, 1992 PCT Filed Apr. 29, 1992 PCT Pub. No. WO92/19120 PCT Pub. Date Nov. 12, 1992.The present device comprises a pin (8) affixed to the end of the strip (1) carrying the slider (4) and a plate (14) affixed to the end of the strip (2) carrying the leader (11). After engagement of the head (9) of the pin (8) inside the hole (17), the pin (8) is guided in the channel (18) while pulling the end of the strip (1) so as to position the leader (11) in front of the opening of the slider (4). This device can be operated with one hand.
Patent DE-69218938-D1 (DE)
Inventor: BOSCHETTI EGISTO
IPC: A61K9/16
Filed: 1992-05-20
Granted: 1997-05-15
Abstract: The present invention concerns the use of microspheres for therapeutic embolization consisting of a hydrophilic acrylic copolymer coated with a cell adhesion promoter.
Patent DE-69224027-D1 (DE)
Inventor: ZAMBIAS ROBERT A
IPC: A61K38/00
Filed: 1992-10-01
Granted: 1998-02-19
Abstract: Certain bisamine compounds which have cyclohexapeptidyl nucleus and which are found to have antibiotic activity with physical properties suitable for direct use in therapeutic compositions are described. A novel process for their preparation is also described.