baber/WOPTO huggingface dataset:
Patent DE-69900592-D1 (DE)
Inventor: VAN GEMEN B
IPC: C12Q1/68
Filed: 1999-01-21
Granted: 2002-01-24
Abstract: The present invention is concerned with a method for generating, in a non specific manner, multiple copies of RNA from a pool of mRNA's. Such a method is of particular importance in techniques for screening the differences in expression in given cell types or in cells under specific conditions. The present invention provides a non-selective poly A mRNA labeling and amplification method, i.e. a method not encompassing cDNA synthesis. The present invention is directed to a method for amplifying RNA by creating, in a non specific manner, multiple RNA copies starting from nucleic acid containing starting material comprising a pool of mRNA's each mRNA comprising a poly-A tail, wherein the material is contacted simultaneously with an oligonucleotide comprising an oligo-dT sequence, the sequence of a promoter recognized by an RNA polymerase and a transcription initiation region which is located between the oligo-dT sequence and the sequence of the promoter, and further with an enzyme having reverse transcriptase activity, an enzyme having RNase H activity and an enzyme having RNA polymerase activity and the necessary nucleotides and the resulting reaction mixture is maintained under the appropriate conditions for a sufficient amount of time for the enzymatic processes to take place. In a preferred method of the invention the generated RNA copies made are contacted with an RNA ligase, a double stranded nucleic acid complex comprising a double stranded DNA promoter sequence that can be recognized by an RNA polymerase, whereby one strand of said complex has a stretch of RNA attached to the 5' end of one of the DNA strands, an enzyme having RNA polymerase activity, and the necessary nucleotides. The resulting reaction mixture is maintained under the appropriate conditions for a sufficient amount of time for the amplification to take place.
Patent DE-69909594-D1 (DE)
Inventor: ACHTEN AUGUSTINUS
IPC: F04B1/20
Filed: 1999-02-10
Granted: 2003-08-21
Abstract: The invention relates to an apparatus for executing activities assisted by equipment driven by means of rotating or linear hydromotors. The hydromotors may be loaded and/or moved in two directions. The hydromotors are coupled via a connecting line and a hydraulic transformer with a high-pressure line. The hydraulic transformer is provided with adjusting means for controlling the hydromotor and control means are provided for restricting the fluid flow in the hydraulic transformer.
Patent DE-69914120-D1 (DE)
Inventor: MENDOZA SORIA
IPC: F24C3/08
Filed: 1999-03-31
Granted: 2004-02-19
Abstract: The base is unique in that it is composed of non-porous vitrified refractory material. The construction method involves mixing a number of atomised powder-based components to which water and a mould release agent are then added, the mixed product being selected by means of a sieve test before being cast and pressed; the base obtained thereby is dried with hot air, polished, fired for the first time, glazed and fired again.
Patent DE-69915063-D1 (DE)
Inventor: BAIN I
IPC: C07C/
Filed: 1999-04-01
Granted: 2004-04-01
Abstract: Aminocyclohexyl ether compounds of formula (I), or a solvate or pharmaceutically acceptable salt thereof: <CHEM> are disclosed. In said formula, A, X and R, -R5 have the meanings given in the description. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
Patent DE-69916145-D1 (DE)
Inventor: ALBARRAN WOLFGANG
IPC: C21B13/00
Filed: 1999-01-21
Granted: 2004-05-13
Abstract: A separator for use in a direct reduction reactor comprises an elongated tubular housing having a cooling chamber for receiving a cooling medium for cooling the internal wall surface of the separator contacted by metallized iron fines. <IMAGE>
Patent DE-69918108-D1 (DE)
Inventor: BENZ H
IPC: G02B1/04
Filed: 1999-01-06
Granted: 2004-07-22
Abstract: A one piece intraocular lens and an intraocular lens include an optic portion and a haptic portion formed from a copolymer that includes an incorporated hydrophilic monomer and an incorporated alkoxyalkyl methacrylate monomer. The optic and haptic portions of the one-piece intraocular lens and intraocular lens are formed from the same copolymer. The copolymer of intraocular lenses and preferred one-piece intraocular lenses includes about 40 to about 95 percent by weight of the hydrophilic monomer based on the total weight of the dry copolymer and about 5 to about 60 percent by weight of the alkoxyalkyl methacrylate based on the total weight of the dry copolymer. A blank for use in constructing an intraocular lens includes a hydrogel in a shape suitable for finishing into an intraocular lens. The hydrogel of the blank comprises a first portion suitable for finishing into a haptic portion and a second portion suitable for finishing into an optic portion. The first and second portions of the blank are formed of the same or a different copolymer of a hydrophilic monomer and an alkoxyalkyl methacrylate monomer, and the amount of the hydrophilic monomer present in the copolymer of the first portion of the blank ranges from about 60 to about 80 percent by weight based on the total weight of the dry copolymer in the first portion. Copolymers of the blank and one-piece intraocular lenses have an equilibrium water content of from about 10 to about 38 percent by weight based on the total weight of the hydrated copolymer.
Patent DE-69919513-D1 (DE)
Inventor: KIKUKAWA HIDEAKI
IPC: A63F13/45
Filed: 1999-12-08
Granted: 2004-09-23
Abstract: An effect application instructing function includes a user setting function for setting up information as to users of an entertainment apparatus to generate a user information table, an event processing function for reading input information from one or more manual controllers and processing data depending on the input information to generate an event processing table, a vibration setting function for extracting only information relative to vibrations from the event processing table and successively registering vibrations types with respect to the user to which vibrations are to be applied in a vibration output table, and a vibration outputting function for generating and outputting vibration indicating data including a vibration type with respect to the user to which vibrations are to be applied, based on the vibration output table and the user information table, and executing a physical effect to be applied to a hypothetical user as a parameter change.
Patent DE-69919809-D1 (DE)
Inventor: LEOPOLD PHILLIP M
IPC: B29C45/53
Filed: 1999-10-28
Granted: 2004-10-07
Abstract: A moulding machine for moulding microparts containing between 0.001 to 3.5 cubic centimetres of plastics shot volume includes a plasticizing portion operatively connected to an injection portion and a mould portion. A valve member is provided to open and close the connection between the plasticizing portion and the injection portion. A linear motor member is associated with the injection portion to permit moulding times of 0.01 seconds at pressures up to about 690 MPa (100,000 psi) during injection of the molten plastics material into the mould portion. <IMAGE>
Patent DE-69921942-D1 (DE)
Inventor: VICTOR GUILLEN CHICO
IPC: E06B9/78
Filed: 1999-05-11
Granted: 2004-12-23
Abstract: Multipurpose construction and single positioning of the case (5) between a retractable cover (1) and a body (2), both being reinforced by discs (3), with a clear front for accessing the case (5) provided with a brake pin (5.2), the body being provided with exchangeable support legs (6) and/or caps (7) ending in a hook, as well as optimising ring (5.3) with embedded tab (5.3.1), as well as shaft (10.4) elements, braking systems with beam (8), and, if required, guide (8.1) and cord coil (9) winding systems. <IMAGE>
Patent DE-69931480-D1 (DE)
Inventor: YEANEY L
IPC: F21V14/02
Filed: 1999-03-19
Granted: 2006-06-29
Abstract: An arm assembly (32, 34) for supporting a surgical lighthead (36, 38) of a surgical light apparatus (30) includes a first arm (46) and a first clevis (96) appended to the first arm (46). The first clevis (96) has a pair of separated first flanges (110). The first clevis (96) further includes a first stop surface (230) and a second stop surface (232). The arm assembly (32, 34) includes a second arm (48) which is formed to include an interior region. The surgical lighthead (36, 38) is supported by the second arm. A second clevis (98) is appended to the second arm (48) and has a pair of separated second flanges (116). The second clevis (98) further includes a third stop surface (234) and a fourth stop surface (236).
Patent DE-69940633-D1 (DE)
Inventor: SAKAI ATSUSHI
IPC: A61P37/08
Filed: 1999-01-19
Granted: 2009-05-07
Abstract: The present invention provides a pharmaceutical composition containing 2-amino-2-Ä2-(4-octylphenyl)ethylÜpropane-1,3-diol or a pharmaceutically acceptable acid addition salt thereof, and cyclodextrin as a stabilizer, and where necessary, saccharide, which can be prepared into a liquid agent, and which is useful for the suppression of rejection in organ or bone marrow transplantation, immunosuppressive sustention therapy therefor or the treatment of autoimmune diseases.
Patent DE-69942135-D1 (DE)
Inventor: WEINGER MURRAY
IPC: B25C1/08
Filed: 1999-04-09
Granted: 2010-04-22
Abstract: A powered tool constructed to drive a driver blade (18) in response to power from a power delivery source (16) to impact a fastener and drive it into a workpiece, comprising: 
a housing (12) having a main chamber (17) enclosing said power delivery source; 
a nosepiece (22) associated with said housing to accept a fastener and guide said driver blade toward impact with said fastener, 
a handle (82); 
a trigger (20) permitting an operator to actuate the power delivery source; 
a fastener supply assembly (24) associated with said housing for supplying fasteners into said nosepiece; 
a tool activation linkage (44) biased into a nonoperational position, and movable into an operational position when said tool is pressed against a workpiece; 
a fastener follower (46) in said fastener supply means (24); 
a distance amplifier lockout (52) to amplify movement of said fastener follower (46) when said fastener follower is brought into contact with said distance amplifier lockout in response to ejection of an individual fastener from said tool, said lockout (52) preventing said tool activation linkage (44) from being moved into said operational position.
Patent DE-69943029-D1 (DE)
Inventor: SCARANTINO CHARLES W
IPC: G16H40/63
Filed: 1999-09-29
Granted: 2011-01-20
Abstract: Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring  in vivo  at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an  in situ  located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantity how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with  in situ in vivo  biocompatible sensors and telemetry based operations and related computer program products.
Patent DE-502004001060-D1 (DE)
Inventor: THANNHUBER MARKUS
IPC: G05D1/02
Filed: 2004-02-23
Abstract: The method involves determining the positions of reflective devices, determining the boundaries of the surface, determining a path for the movement of the vehicle and then processing the surface. The positions of the reflective devices are determined by transmitting physical signals from the vehicle and receiving reflected signals from the devices, changing the vehicle position and determining corresponding angular positions of the devices. The method involves determining the positions of a number of reflective devices (5), determining the boundaries of the surface to be processed, determining a path for the movement of the vehicle and then processing the surface. The positions of the reflective devices are determined by transmitting physical signals from the vehicle and receiving reflected signals from the devices, changing the vehicle position and determining corresponding angular positions of the devices. An independent claim is also included for the following: (a) an earth processing machine.
Patent DE-502004008191-D1 (DE)
Inventor: SCHNEID JOSEF
IPC: D21F1/40
Filed: 2004-07-28
Abstract: A papermaking expander drum (22) has an outer case (26) that is subjected to bending inputs introduced via the end face (28). In an alternative embodiment the bending moments are introduced via two or more radial bearings inside the case. The bearing support points (32, 34) are movable and adjustable. The adjustment takes place about a swivel axis (38). The expander drum (22) is metal.
Patent DE-502004009271-D1 (DE)
Inventor: BERGMANN HANS-PETER
IPC: D21C9/10
Filed: 2004-05-07
Abstract: The invention relates to a method for bleaching fibrous materials, in particular lignin-containing materials for producing paper consisting in adding at least a first additive and at least one type of bleaching liquid to a fibrous solution which contains at list one bleaching agent. After mixing said bleaching solution with the fibrous suspension and at the end of determined bleaching time, the bleaching process is ended by adding at least a second additive. Said invention is characterised in that the pH of the fibrous suspension is obtained by adding lime.
Patent DE-502004009563-D1 (DE)
Inventor: GRAEWE BERND
IPC: F16B13/12
Filed: 2004-04-28
Abstract: The system has a wall with a case (2) having a retainer (3) with a retainer shank (4) being in a through-hole (6). A head (13) is positioned at a final position being in a moveable area close to the retainer shank. A fastener is located into a thread section (9) of the through-hole allowing a screw to be slotted in it. The head of the fastener is sharp-edged and in a final position of the fastener a recess for outer contour of the head is provided. The thread section of the case is implemented with a round thread (19).
Patent DE-502004010837-D1 (DE)
Inventor: STRIGGOW FRANK DR
IPC: A61P25/16
Filed: 2004-08-10
Abstract: The use of inhibitors (I) of enzyme(s) selected from dipeptidyl peptidase IV (DP IV), alanyl-aminopeptidase (aminopeptidase N: APN) and/or enzymes of the same substrate specificities is claimed for reducing neurodegenerative lesions caused by the formation of aggregates of misfolded proteins (e.g. neurofibrillar tangles (NFT)) and blocking or modulating inflammation caused by such lesions, is new. Independent claims are included for: (1) corresponding therapeutic or prophylactic methods using (I); and (2) pharmaceutical preparations (not restricted to particular activities or applications) containing (I) in combination with conventional carriers, additives and/or auxiliaries. ACTIVITY : Neuroprotective; Antiinflammatory; Nootropic; Antiparkinsonian; Anticonvulsant; Antibacterial. Tests were carried out in transgenic mice expressing the human microtubuli-associated tau protein with the P301L mutation under the control of the mouse prion promoter, which develop age-dependent NFT, neurodegeneration and movement deficiency and are a good model for tauopathy in humans (see Nat. Genet., 2000, 25(4), 4020405). Intraperitoneal administration of combinations of DP IV inhibitors (I-49) and APN inhibitors (bestatin hydrochloride, actinonin) at doses of 5-10 mg/kg or the individual inhibitors at 50 mg/kg every 2 to 3 days significantly reduced the number of NFT in both the entorhinal cortex of one hemisphere and the hippocampus of the contralateral area (no quantitative results given), the reduction being greater using a combination of the two types of enzyme inhibitors. MECHANISM OF ACTION : Dipeptidyl peptidase IV (DP IV) inhibitor; alanyl-aminopeptidase (aminopeptidase N: APN) inhibitor.
Patent DE-502005000366-D1 (DE)
Inventor: PRITSCHINS WOLFGANG DR
IPC: C09K23/42
Filed: 2005-08-30
Abstract: Copolymer (I) (obtained by copolymerization of: ethylenic unsaturated 1,2-dicarbonic acid derivates (A) (1-80 mol.%); unsaturated mono carbonic acid derivative (B) (2-80 mol.%); polyalkylenoxyallylethers (C) (1-90 mol.%); further unsaturated monomers (D) (0-30 mol.%); and reaction products of copolymer with ammonia, amine, water, alcohol, amino alcohol and/or alkali or alkaline-earth hydroxide) is new. Copolymer (I) (obtained by copolymerization of: ethylenic unsaturated 1,2- dicarbonic acid derivates (A) (1-80 mol.%); 12-30C unsaturated mono carbonic acid derivative (B) (2-80 mol.%); polyalkylenoxyallylethers (C) with average molecular weight up to 5000 g/mol (1-90 mol.%); further unsaturated monomers (D) (0-30 mol.%), which are not (A-C); and the reaction products of copolymer with ammonia, amine, water, alcohol, amino alcohol and/or alkali or alkaline-earth hydroxide) is new. Independent claims are also included for: (1) the preparation of (I); and (2) a composition (III) comprising (I).
Patent DE-502005002434-D1 (DE)
Inventor: DOERSCHUG UWE
IPC: B02C4/30
Filed: 2005-05-07
Abstract: The invention relates to a grinding roller (1) that can be integrated into a roller mill, especially a particle bed roller mill, comprising two grinding rollers (1) which are driven in counterrotation and form a gap thereinbetween for the material to be ground. Said grinding roller comprises a steel roller base body (2) and a hard material shell (3) which is applied thereto by means of plasma powder build-up welding. The aim of the invention is to improve the wearing and operating behaviour of such grinding rollers. To this end, the roller base body (2) consists of a low-carbon, low-alloy case-hardened steel, and the hard material shell (3) consists of a low-carbon, high-alloy steel material.
Patent DE-502005003072-D1 (DE)
Inventor: NOLL TINO
IPC: G02B7/182
Filed: 2005-10-11
Abstract: The device has a solid hinge designed as a thread adjusting unit (FJE), and exhibiting a twistable thread (FA) which is firmly connected with an object (OB). A longitudinal deflection of the thread adjusting unit takes place by moving a fastening point of the thread at a linear drive (AN) which is connected with a base. The movement and free length of the thread determines a distance between the object and the base.
Patent DE-502005004364-D1 (DE)
Inventor: SCHAUB HARTMUT
IPC: D06F35/00
Filed: 2005-11-21
Abstract: During a first process (A1) the drum is alternatively rotated at 50rpm followed by a subcritical speed of 100rpm (11), followed by an identical process (A2), followed by a third (A3) and a higher spin speed of 400rpm (12) repeated by another (A4) and finally by four processes (A5-A8) at 800rpm (13).
Patent DE-502005004595-D1 (DE)
Inventor: BREILING MARCO
IPC: H04L27/26
Filed: 2005-12-12
Abstract: A signal converter for converting a start signal into an end signal includes means for copying the start signal to obtain a plurality of copied start signals, wherein a copied start signal may be fed into a processing branch as a branch signal. Further, the signal converter includes a first branch processing means in a first processing branch for processing a first branch signal according to a first processing regulation to obtain a first processed branch signal. Further, the signal converter includes a second branch processing means in a second processing branch for processing a second branch signal according to a second processing regulation to obtain a second processed branch signal, wherein the second processing regulation is different from the first processing regulation and wherein the first processing regulation and the second processing regulation are implemented to cause a low-pass polyphase filtering of the copied start signals. Finally, the signal converter includes selection means for sequentially selecting the first processed branch signal and then the second processed branch signal in order to obtain the end signal.
Patent DE-502005005261-D1 (DE)
Inventor: WEDER MICHAEL
IPC: D06F37/20
Filed: 2005-02-22
Abstract: The connecting device for the connecting of a vibration damper to a washing machine and/or a frame of a washing machine has a fastening sleeve (25) for fitting in an eye of the damper, and a pin (26) for fitting in the fastening sleeve. The pin is transferable from an initial position into a locking position through inserting into the fastening sleeve and can be axially fixed in the locking position in relation to the fastening sleeve.
Patent DE-502005005826-D1 (DE)
Inventor: JOHNEN MARKUS DR-ING
IPC: H01R39/38
Filed: 2005-11-18
Abstract: The holder has a guide housing (6) for receiving a contact brush (8) and a holding device (12) provided at the guide housing for fixing a brush strand (10) such that the length of the brush strand is provided for pushing the contact brush. The holding device has a clamp opening (18) that is tapered in an insertion direction. The strand is directly attached to a contact of an operating circuit in an electric motor. The housing includes a sheet material and the holding device includes a bar (16) notched from a wall (14) of the housing.
Patent DE-502005006311-D1 (DE)
Inventor: SAGER BRUNO
IPC: B65D88/52
Filed: 2005-05-10
Abstract: The levee construction unit takes the form of a water container (1) with a bottom (2) and a side wall (3) which is made up of wall elements flexibly joined to one another by vertical joints. An independent claim is also included for a levee made up of the proposed construction units.
Patent DE-502005006747-D1 (DE)
Inventor: KOCH MARTIN
IPC: A44B19/16
Filed: 2005-01-21
Abstract: A docking seal system has a first flexible enclosure with a first coupling seal and a second flexible enclosure with a second coupling seal. Each of the coupling seals has first and second sealing strips. A first zip slide is engageable with the first and second sealing strips of the first coupling seal and a second zip slide is engageable with the first and second sealing strips of the second coupling seal so that the respective first and second coupling seals can be opened and closed. The first and second zip slides are each combined with a respective portion of a coupling slide to form respective combined slides. When the combined slides are combined together, the respective portions of the coupling slides mate together to form the coupling slide, the coupling slide engaging or disengaging the first and second coupling seals so as to dock or separate the first and second flexible enclosures from one another.