baber/WOPTO huggingface dataset:
Patent EC-SP055847-A (EC)
Title: Derivados de dihidropiranoindol-3,4-diona sustituidos y derivados de 2-hidroximetilindol del ácido 3-oxoacético sustituidos como inhibidores del inhibidor del activador de plasminógeno 1 (pai-1)
Inventor: LI DAVID ZENAN
IPC: C07D209/22
Filed: 2005-06-09
Abstract: ResumenSe proveen compuestos de las fórmulas (I) y (II): y en las que: X es un metal alcalino o un resto de amina básica; R1 es alquilo, cicloalquilo, -CH2-cicloalquilo, piridinilo, -CH2-piridinilo, fenilo o bencilo, en donde los anillos de estos grupos están opcionalmente sustituidos; R2 es halógeno, alquilo, perfluoroalquilo, alcoxi, cicloalquilo, -C2-cicloalquilo, -NH2 o -NO2; R3 es fenilo, bencilo, benciloxi, piridinilo o -CH2-piridinilo, en donde los anillos de estos grupos están opcionalmente sustituidos; o una de sus sales o formas de ésteres farmacéuticamente aceptables, así como composiciones farmacéuticas y métodos que usan estos compuestos como inhibidores del inhibidor del activador del plasminógeno 1 (PAI-1) y como composiciones terapéuticas para tratar condiciones que resultan de trastornos fibrinolíticos tales como trombosis venosa profunda y enfermedad cardíaca coronaria y fibrosis pulmonar.
Patent EC-SP066948-A (EC)
Title: Benzoxazinas para el tratamiento de enfermedades de las vías respiratorias
Inventor: PESTEL SABINE
IPC: A61K31/538
Filed: 2006-10-23
Abstract: La presente invención se refiere al uso de los compuestos de la fórmula general 1 en donde los radicales R1, R2 y R3 pueden tener los significados mencionados en las reivindicaciones y en la memoria descriptiva, para la preparación de un medicamento para el tratamiento de enfermedades de las vías respiratorias.
Patent EC-SP066962-A (EC)
Title: Compuestos de morfolina sustituida para el tratamiento de trastornos del sistema nervioso central
Inventor: REICHARD GREGORY A
IPC: C07D413/06
Filed: 2006-10-30
Abstract: La invención se refiere a compuestos de fórmulas I en las que R1-R8, A, X, y Z se definen como en la memoria descriptiva, a composiciones farmacéuticas que los contienen y a su uso en el tratamiento de trastornos del sistema nervioso central
Patent EC-SP088366-A (EC)
Title: 1,2-diarilimidazoles para uso como moduladores de cb1
Inventor: LUNDQVIST ROBERT
IPC: C07D233/90
Filed: 2008-04-14
Abstract: Sales de 1,2-diarilimidazol-4-carboxamidas y procesos para preparar dichos compuestos, su uso en el tratamiento de la obesidad, trastornos psiquiátricos y neurológicos, métodos para su uso terapéutico y composiciones farmacéuticas que los contienen.
Patent EC-SP992995-A (EC)
Title: Antagonistas de receptor muscarinico
Inventor: MAMMEN MATHAI
IPC: C07D213/02
Filed: 1999-06-08
Abstract: Se revelan compuestos multiaglutinantes que son antagonistas de receptor muscarínico. Los compuestos multiaglutinantes de la presente invención que comprenden de dos a 10 ligandos se sujetan covalentemente a uno o dos enlaces. Cada ligando, independientemente entre si, es un antagonista de receptor muscarinico. Los compuestos multiaglutinantes de la presente invención son útiles en el tratamiento y prevención de enfermedades tales como enfermedad pulmonar obstructiva crónica, bronquitis crónica, síndronme de intestino irritable, incontinencia urinaria y similares.
Patent FI-20065405-A (FI)
Inventor: TIITTA MARJA
IPC: B01J/
Filed: 2006-06-14
Abstract: The present invention relates to a process for producing polyolefms wherein a feedstock comprising n-olefin or a mixture of n-olefins is dimerized in the pres- ence of a solid acidic catalyst by passing the feedstock to a catalytic distillation apparatus comprising either a) a combination of a distillation column and a reactor comprising at least one catalyst bed, or b) a distillation column connected to one or more side reactors comprising at least one catalyst layer, recovering the unre- acted n-olefin from the distillation column or the combination of the distillation column and the reactor at the upper part thereof as a side-stream to be combined with the feedstock, and the reaction product from the dimerization is hydrogen- ated.
Patent GB-1047226-A (GB)
Abstract: 1,047,226. 1,3-Diarylpyrazoline-sulphones. FARBWERKE HOECHST A.G. April 22, 1963 [April 21, 1962], No. 15799/63. Heading C2C. [Also in Divisions C5 and D1] Novel compounds of formula  in which R represents a phenyl radical which may be substituted once or several times by halogen atoms or alkyl or alkoxy groups having 1-5 carbon atoms, and X represents -CH= CH 2  or -CH 2 -CH 2 -SO 3 Me, where Me represents a cation, may be prepared by reacting #-halogeno-alkylarylketones with hydrazinophenyl-#-sulphoethylsulphones, esterifying the compounds of Formula I in which X is -CH 2 CH 2 OH, thus obtained, with concentrated sulphuric acid, and obtaining the sulphuric acid esters which can be isolated in the form of their alkali metal salts, or (a) converted in an aqueous solution by the action of alkaline agents into the very reactive vinylsulphonyl compounds of Formula I in which X is -CH=CH 2 , or (b) reacted with salts of sulphurous acid, if desired at elevated temperature to give the salts of the #-sulphoethylsulphonyl compounds of Formula I in which X is -CH 2 CH 2 SO 3 Me.
Patent GB-1050164-A (GB)
IPC: C08J9/00
Abstract: A process for the continuous production of a foamed cross-linked ethylene polymer and/or copolymer which has incorporated therein a blowing agent and a cross-linking agent comprises softening the ethylene polymer and/or copolymer with an organic solvent having a boiling-point of at least 40 DEG  C. to permit the incorporation of the blowing and cross-linking agents into the polymer prior to extrusion and then extruding the composition at a temperature of from 100-180 DEG  C.  The organic solvent may be absorbed in a filler before being incorporated in the polymer.  Solvents specified are halogenated hydrocarbons, benzine, benzene, toluene, xylene, cyclohexane, methyl ethyl ketone, acetone, methyl glycol acetate, butyl acetate and butanol. Cross-linking agents are advantageously dialkyl peroxides with tertiary carbon atoms.  Ethylene polymers and copolymers used in examples are high pressure polyethylene, low pressure polyethylene and a copolymer of 67% ethylene and 33% vinyl acetate. Blowing agents may be either solid or liquid, those used in the examples are dinitrosopentamethylene tetramine, azodicarbonamide, trichloroethylene, methylene chloride, 1,2-di-chlorotetrafluoroethane and trichloromonofluoromethane.
Patent GB-1051483-A (GB)
IPC: B06B1/16
Abstract: 1,051,483. Vibratory mechanisms. LOSENHAUSENWERK DUSSELDORFER MASCHINENBAU A.G. March 24, 1964 [March 30, 1963; June 12, 1963], No. 12294/64. Heading F2X. A vibrator comprises an unbalance mass mounted with axial symmetry on a hollow shaft through which extends a shaft carrying an unbalance mass on each end, the two shafts being geared together for opposite rotation. In Fig. 1, the hollow shaft 4, carrying unbalance masses 6, 6a, at its ends and the rotor 3 of a driving motor on its middle portion, is connected through a ring gear 5a and pinions 12, 13, 11 to the inner shaft 7, carrying unbalance masses 8, 8a at its ends, so that the two shafts rotate at equal speeds but in opposite senses. The shaft 7 also carries a cooling fan 15 for the motor. To alter the phase relation between the shafts 4, 7, and hence the direction of the vibrations, the bearing plate carrying the pinions 12, 13 may be rotated in the casing 1. In Fig. 2. an external drive is applied to the vibrator through a pinion or pulley 28 on an inner shaft 22 which carries unbalance masses 29, 30. An unbalance mass 35 is fixed on the centre portion of a hollow shaft 23 surrounding the middle portion of the shaft 22. Idler pinions 39, 40, meshing respectively with a ring gear 37 on the hollow shaft 23 and with a gear 38 on the shaft 22, are carried in a cage comprising plates 43, 44 linked by a bridge member and rotatably mounted on the shaft 22. To alter the phase relation between the shafts 22, 23, the cage is turned by a worm 48, having a hand wheel 49, meshing with a worm-wheel formed on the plate 44. In either embodiment, more than one pair of pinions 12, 13 or 39, 40 may be used, and the gearing connecting the two shafts may be duplicated by adding a second train at the free end of the hollow shaft.
Patent GB-1053147-A (GB)
IPC: G06F7/52
Abstract: 1,053,147. Electronic calculating apparatus. CONTROL DATA CORPORATION. June 3, 1964 [June 4, 1963], No. 22926/64. Heading G4A. Multiplication of two binary numbers is effected by notionally dividing the multiplier into two parts, simultaneously effecting a multiplication of the multiplicand by each, and subsequently adding the two partial products so obtained. To further speed up the process, the multiplier bits in each part are examined in pairs, which control the adding-in of zero, or 1 x , 2 x or 3 x the multiplicand. As shown, the multiplier is first loaded into L-2u and L-2L (most and least significant parts) via A1, and the multiplicand into X-1. The apparatus uses two " adding pyramids " described in Specification 1,053,146, and shift units 16, 16<1> which effectively enter numbers into the pyramids at one higher binary order (this multiplying by two). Thus by opening gates 12 and 14 A-1 can deliver 3 x multiplicand to X2. Translators A-1, Q-1 now sense the two lower order bits in both L-2u and L-2L to control the delivery to the pyramids via gates 24 of the appropriate multiple of the multiplicand, where it is added to the contents of the accumulator sent via gates 30, 30<1>, and shift pulses shift the two lowest bits of the partial product into L-2u, L-2L which are arranged to form single shift registers with the accumulators. Thus the next two bits of each half of the multiplier are ready for translation. Finally the partial products now shifted into L-2u, L-2L are supplied (appropriately aligned) to the adding pyramids to produce the final (doublelength) product which is sent to the accumulators.
Patent GB-1053961-A (GB)
IPC: B05C1/08
Abstract: 1,053,961. Coating apparatus. BOSTIK Ltd. March 19, 1964 [March 21, 1963], No. 11601/ 64. Heading B2L. An adhesive applying apparatus comprises a disc 20 (Figs. 2 and 4 not shown) mounted to rotate in a part circular cavity 23 in an electrically-heated casing 22, part of the space between the periphery of the disc and the arcuate wall 23 of the cavity defining a chamber 44 to which molten thermoplastic adhesive composition is supplied and from which a film of the composition is carried forward by and on the periphery of the disc to be applied to an article brought into contact with the disc where it protrudes from the casing. The adhesive composition is supplied to the apparatus in the form of a rod R which is advanced by feed wheels 32, 34 into a bushing 31, and via passages 30, 66 to a further passage 70 which is defined by a groove in one side wall of the cavity 23 and by the side face of the disc. The passage 70 is of arcuate form and is concave with respect to the axis of the disc and extends to the adhesive chamber 44, rotation of the disc co-operating with the arcuate shape of the passage 70 to provide a pumping action on the molten adhesive composition. An adjustable doctor device 26 regulates the thickness of the film of adhesive deposited upon the disc. A pivoted vane mounted in a V-shaped recess 50 in the casing adapted to be adjusted in position by the quantity of adhesive composition in the chamber 44 acts upon a microswitch 60 to interrupt the feed of the rod R of adhesive material as required. In a modified embodiment (Fig. 3 not shown) the passage or groove in the side wall of the cavity is of spiral form and subtends an angle of more than 360 degrees at the axis of the disc.
Patent GB-1084045-A (GB)
IPC: H04R1/08
Abstract: 1,084,045. Microphones. AKUSTISCHE U. KINO-GERATE G.m.b.H. Oct. 6, 1964 [Oct. 7, 1963], No. 40732/64. Heading H4J. [Also in Division E2] An adapter for making a quick connection between a microphone 1 and a stand 4 comprises a retaining part 2 either adapted to be inserted into or adapted to be fitted on to a microphone housing and a part 3 adapted to be inserted into an opening 4a conforming to the cross-section of the part 3 and formed in a stand or in a connector adapted to be screwconnected to a stand. As shown the parts 2, 3 are pivotally connected by a screw but they are alternatively connected by a ball-and-socket joint or a flexible tube. The part 3 has a detent spring with a projection 3c which bears on a nose 4b in the opening 4a when the part 3 is inserted therein to retain the part in the opening, the part being free by depressing a finger-engageable extension 3b on the spring. The retaining part 2 is secured to the microphone 1 either by a shoe-like extension 2a, Fig. 1, thereon engaging in a slot in the microphone housing, or by providing a split sleeve 7, Fig. 5a at the end of the part 2 in which the microphone housing is received and held either by the resilience of the sleeve 7 or by a resilient piece 8 projecting from the sleeve wall. In one or both of the parts 2, 3 or between the parts a resilient sound lagging insert is provided shown as applied to the part 3 in Fig. 4. The insert comprises a collar 3g between sections 3d and 3e of the part 3, and extensions 3f filling apertures in the sections 3d, 3e, the assembly being held together by a tubular rivet.
Patent GB-1143734-A (GB)
IPC: C08G63/672
Abstract: 1,143,734. Polymers from polyethers and polycarboxylic anhydrides. CHEMISCHE WERKE HULS A.G. 24 June, 1966 [25 June, 1965], No. 28373/66. Heading C3R. Polymers containing ester bonds are made by reacting a polyether of molecular weight 1,000 to 1,000,000 with a polycarboxylic acid anhydride in the presence of an initiator system comprising a mixture of or an addition product of a Lewis acid and a co-catalyst which is a compound which forms cations with Lewis acids. Specified co-catalysts are organic halogen compounds and epoxides and mixtures of either of these with oxonium compounds. Specified polyethers are polyethylene oxide, polytrimethylene oxide, polytetramethylene oxide, polypentamethylene oxide, polyhexamethylene oxide and poly-3,3-bis.chloromethyl-oxacyclobutane. Specified anhydrides are succinic, methylsuccinic, glutaric, ethylglutaric, maleic, methylmaleic, chlorendic, endomethylenetetrahydrophthalic, phthalic, hexahydrophthalic, tetrachlorophthalic, mono- and di-pyromellitic, trimellitic, polyadipic, polyazelaic and polysebacic anhydrides. Examples describe reacting (a) polyethylene oxide and succinic anhydride and (b) polytetramethylene oxide and succinic or maleic anhydrides.
Patent GB-1226346-A (GB)
IPC: B60T8/40
Filed: 1968-08-01
Abstract: 1,226,346. Anti-skid braking systems. MULLARD Ltd. 1 Aug., 1968, No. 36746/68. Heading F2F. An anti-lock brake system for a wheeled vehicle includes a fluid pressure line for connection from a fluid pressure source to a wheel brake controlled by the system, an elongate slide member arranged for longitudinal movement into a section of the line, which member is so dimensioned as to provide between itself and the inner wall of the section a clearance which forms a restricted fluid path in the section, and means for varying the extent of penetration of the slide member into the section during operation of the system to cause variation of the length of the fluid path and thus of the restriction afforded by it. As shown in Fig. 4, when a valve VI is opened by an actuator responding to wheel speed reduction, fluid is able to flow from the brake line W to a reservoir chamber C. Piston P1 in the reservoir is thereby moved to the right against spring S, and slide R1 forming an extension of the piston causes further restriction of the path from the master cylinder to the brake line. The increase in restriction is a function of degree of filling of the reservoir. Optionally a second restrictor slide R2 extending from the other side of the piston operates in the line from the reservoir to the scavenging pump Ps so as to be effective just when the tip of R1 is beginning to uncover the inlet port, to act as a temporary check to scavenging. In Fig. 6 (not shown), the spring S (which is not essential), is omitted. Fig. 5 (not shown), is analogous to Fig. 4, but the scavenging pump and master cylinder are replaced by a high-pressure pump, a pressure reservoir and a brake-pressure control, in series. Fig. 7 resembles Fig. 4, but the spring S is replaced by a smaller piston P2 linked to piston P1. Fig. 8 is a practical embodiment of Fig. 7, where face A corresponds to piston P2 and face B to piston P1.
Patent GB-1226532-A (GB)
IPC: H03M1/00
Filed: 1967-06-21
Abstract: 1,226,532. Analogue / digital converters. PLESSEY CO. Ltd. 14 June, 1968 [21 June, 1967], No. 28742/67. Heading G4H. To digitize an analogue signal V in  (Fig. 3) a fixed reference quantity Vref is subtracted from the unknown analogue signal the first digital output bit being determined by the polarity V in -V ref , the process then being repeated with an input signal 2(V in -V ref ) if V in >V ref  or 2V in  if V in <V ref  to give the next digital bit. In the embodiment described, initially a MOST T1 is in its low impedance state so that 2V ref  is subtracted from 2V in  in a differential amplifier A3, the output from which is compared with zero in comparator A4 and fed via MOST T5 enabled by a pulse # 1  to capacitor C1 and MOST T6 from which the digital output is taken. At pulse # 1 , then enables MOST T7 so that depending on the polarity of the signal either MOST T1 or T2 is driven to its low impedance state so that either 2(V in -V ref ) or 2V in  is fed via a conductor 12 to a sample and hold circuit for the next digital bit to be determined. Either the same circuitry may be used to generate subsequent bits or a number of similar circuits connected in cascade may be used. The MOST transistors may be replaced by multi-emitter transistors or reed switches.
Patent GB-1227954-A (GB)
IPC: C01B13/11
Filed: 1967-05-12
Abstract: 1,227,954. Producing ozone. O-THREE INSTRUMENTS Ltd. 6 May, 1968 [12 May, 1967], No. 22084/67. Heading H5H. An electric potential is applied between an imperforate planar electrode 6 and a perforated planar metallic electrode 2 separated by a planar electrically insulating film 4, thereby generating ozone within the interstices of sheet 2 for air freshening purposes. Film 4 is about three thousandths of an inch thick and is a thermoplastic of polyester, polyolefin or polystyrene. Electrode 2 is a stainless steel gauge having 30 wires to the inch or may be an anodized aluminium sheet 15, Fig. 5, perforated with rectangular slots 16 formed with smooth surfaces contacting the film 4. Film 4 is secured around the ends of an insulating board 5 carrying a copper foil 6 constituting the imperforate electrode. Curved pressure spring 7, Fig. 1, fixed to the plastics housing 1 act on board 5 to press foils 6 against film 4, which is in turn pressed against gauge 2 which is supported by vertical plastics ribs (not shown). Connection to foil 6 is via spring 7 and a contact 8 through the board 5, while connection to gauge 2 is via a contact spring 9. The lead from transformer 13 includes a current limiting resistor 14, the mains current being connected via a switch 12. Aluminium sheet 15, Fig. 5, is adhered to the insulating film side of a composite unit of film 4 and copper foil 6 by lines of adhesive material such as 18, the slots 16 in sheet 15 extending across the areas of the sheet which are not in contact with the lines of adhesive. The composite unit 4, 6 is cemented to an insulating board 5 (see also Fig. 4, not shown), and the assembly is held in place by a pair of metal grip clips 19, one at each side, the need for pressure springs 7 being removed. The control circuit may include an indicating lamp 20. Fig. 6 (not shown).
Patent GB-1228177-A (GB)
IPC: C08G65/18
Filed: 1968-07-05
Abstract: 1,228,177. Polymers of oxetane derivatives. KALLE A.G. 5 July, 1968 [6 July, 1967], No. 32269/68. Heading C3R. [Also in Division G2] Polymers which are cross-linkable by light are derived from an oxetane of the general formula wherein R 1  represents or where R 2  is hydrogen, halogen, alkyl, alkoxy or aryloxy or the group R 1 , R 3  is a carbocyclic or heterocyclic aromatic group linked by a ring carbon atom, R 4  is hydrogen, halogen, alkyl or alkoxy, R 5  is chlorine or phenyl, m is 0 or 1 and n is 0 to 4. They may be homopolymers or copolymers with a light-insensitive oxirane, oxetane or oxolane, e.g. propylene oxide, styrene oxide, tetrahydrofuran, 1,4- epoxy-cyclohexane or a compound of the formula where X is H, halogen, alkyl, alkoxy, aryloxy, cyano or acyloxy. The preferred R 3  groups are phenyl, 4-methyl and isopropyl-phenyl, methylene - dioxy - (3,4) - phenyl, 4 - azido - phenyl and thienyl-2. Polymerization is effected in the presence of cationic catalysts, e.g. BF 3 - etherate, PF 5  and trialkyl oxonium salts. Epichlorhydrin may be added after the catalyst as initiator. Fillers may be mixed with the polymers, e.g. polyethers, vinyl polymers and inorganic fillers such as glass beads and silica. The solubility of the polymers is reduced by exposure to light of wave length between 2000 and 7000  as obtained from carbon arc, xenon and mercury vapour lamps, actinic fluorescent tubes and sunlight. The polymers are used in reproduction materials and printing plates (see Division G2).
Patent GB-1228595-A (GB)
IPC: G03B27/08
Filed: 1968-04-24
Abstract: 1,228,595. Feeding record tapes. BELL & HOWELL CO. 24 April, 1968 [24 April, 1967], No. 19421/68. Heading G5R. Air pressure from a tube 46 urges a tape 32 against a head 23 and causes the mouth 50 of the tube 46 to float clear of the tape against the pressure of an adjustable spring 80. For threading the tape, the tube is swung clear by means of linkage 104,114,96,94.
Patent GB-1229947-A (GB)
IPC: B60N2/48
Filed: 1968-11-07
Abstract: 1,229,947. Vehicle seat head-rests. F. S. SEAGRIM. 22 Oct., 1969 [7 Nov., 1968], No. 52777/68. Heading A4J. A median portion 4 of a seat back is raised by rack and pinion 6, 7 to form a head-rest. Portion 4 is flexible and is accommodated as shown under the seat. In (Figs. 3, 4) a rigid construction is used and an upstanding part (10) of the seat projects in front of the movable back.
Patent GB-1231718-A (GB)
IPC: B23P15/00
Filed: 1969-06-18
Abstract: 1,231,718. Making toroid halves. FRANCE, ARMED FORCES, MINISTER OF. 18 June, 1969 [19 June, 1968], No. 30951/69. Heading B3A. A metallic half toroid of semicircular section is made by spinning a metal sheet to form an annular trough of trapezium section and stamping the trough to deform at least a portion thereof into the semicircular section. An annular blank, Fig. 1a, of 18% Ni maraging steel is spun in two stages, Figs. 1b and 1c, to form a trough of trapezium section. The blank is annealed at 820‹ C. for 1 hr. and the base of the trough machined to reduce its thickness to that of the side walls of the trough. After removing the waste portions, Fig. 1e, the trough is hot stamped to form a semicircular section with extended edges, Fig. 1f. The toroid half is thereafter machined and ground to the desired dimensions, Fig. 1g. A toroid is formed by welding two toroid halves together, one of which is provided with inlet connections. The toroid is finally heated at 820‹ C. for 1 hr. and aged at 480‹ C. for 5 hrs.
Patent GB-1232211-A (GB)
IPC: B29C48/09
Filed: 1968-06-26
Abstract: 1,232,211. Extruding and cutting tubes. DUNLOP CO. Ltd. 26 June, 1968 [23 June, 1967], No. 304141/68. Heading B5A. A tubular extrudate 1 from a die 5, 6 is cut into predetermined lengths by a knife 2. Reinforcing cords or wires 11 can be fed through ceramic inlets 10. The cut lengths are positioned on a tyre building former on which extruded annular sidewall components may also be positioned. The core 4 may be moved to give an extrudate of varying thickness and for diameter. The extrudate may comprise a composite tube of concentric layers.