Patent RU-2343143-C2 (RU)
Title: Cycloalkyl compounds - inhibitors of potassium channels function
Inventor: LLOJD DZHON
IPC: C07C311/16
Filed: 2003-01-31
Granted: 2009-01-10
Abstract: FIELD: chemistry. 
     SUBSTANCE: compound of formula I  , its diastereomers or salts, where dot line represents optional double bond, m and p independently stand for 0, 1, 2 or 3; R 1  stands for H, -N(R 8 )-C(O)-NR 6 R 7 , -N(R 8 )-S(O) 2 -NR 6 R 7 , -N(R 8 )-C(O)-N(R 8a )-S(O) 2 -NR 6 R 7 , etc.; R 1a  stands for H or group OH; or R 1  or R 1a  together form oxo; or R 1  and R 1a  together with carbon atom, to which they are bound, form optionally substituted oxo spiro-condensed heterocyclic group, representing fully saturated 5-member monocyclic group, containing 2 nitrogen atoms; R 2  stands for heteroaryl, (heteroary)alkyl, representing 5-6-member aromatic ring, contaning 1 nitrogen atom and/or 1 atom of oxygen and/or sulphur, and optionally condensed with aryl ring; aryl, (aryl)alkyl, alkyl, alkenyl or cycloalkyl, representing partly or fully saturated C 3 -C 6  monocyclic structure, any of which can be optionally, independently, substituted with one or more groups T 1 , T 2  or T 3 ; J stands for bond, C 1-4  alkylene, R 3  stands for -R 5 , -C(Z 1 )-R 5 , -N(R 8a1 )-C(Z 1 )-R 5 , -N(R 8a1 )-C(Z 1 )-O-R 5 , -N(R 8a1 )-S(O) 2 -R 5 ; R 4  stands for alkyl, halogenalkyl, cycloalkyl, aryl, which can be optionally condensed with heteroaryl 6-member ring, containing 1-2 heteroatoms, selected from group SO 2 , N, etc.; R 5  stands for -NR 6a R 7a  or heteroaryl, (heteroaryl)alkyl, representing 5-6-member aromatic ring, which contains 1-3 nitrogen atoms and/or 1 or 2 atoms of oxygen or sulphur, optionally condensed with heteroaryl ring, representing 6-member aromatic ring, containing 1 nitrogen atom, etc.; R 6a , R 7a  independently represent H, alkyl, aryl, (aryl)alkyl, heteroaryl, representing 5-6-member aromatic ring, which contains 1-2 nitrogen atoms, optionally condensed with aryl or heteroaryl ring, representing 6-member aromatic ring with 1 nitrogen atom; any of which can be optionally, independently, substituted with one or more groups T 1c , T 2c  or T 3c ; R 6 , R 7 , R 8 , R 8a , R 8a1  R 8a2 , and R 9 , independently, represent H, alkyl, hydroxy, alkoxy, (hydroxy)alkyl, (alkoxy)alkyl, (cyano)alkyl, (alkenyl)alkyl, -NR 12 R 13 , cycloalkyl, (cycloalkyl)alkyl, optionally condensed with aryl; aryl, (aryl)alkyl, heteroaryl, (heteroaryl)alkyl, etc.; R 10 , R 10a , R 11  and R 11a , independently, represent H, alkyl, aryl, (aryl)alkyl, , hydroxy, (hydroxy)alkyl; heteroaryl, (heteroaryl)alkyl, representing 5-member aromatic ring, which contains 2 nitrogen atoms, or R 11  and R 11a  can together form oxogroup, or R 10a  can together with R 11a  form bond, or R 10  can together with R 9  form saturated 3-4-member cycle; R 12  and R 13 , independently, represent H, alkyl; W represents =NR 8a2 , =N- CO 2 R 8a2 , =N- CN; X represents C(=O), C=N-CN; Z 1 represents =O, or =N-CN; R X  represents one optional substituent, bound with any suitable carbon atom in cycle, independently selected from T 1g , T 2g  or T 3g . Compounds of formula I are applied for manufacturing medication for treatment of I Kur -mediated disorders. 
     EFFECT: cycloalkyl compounds, useful as inhibitors of potassium channels function. 
     13 cl, 694 ex, 1 tbl