baber/WOPTO huggingface dataset:
Patent WO-2020229362-A1 (WO)
Title: Bnip3 peptides for treatment of reperfusion injury
Inventor: RASSAF TIENUSH
IPC: C07K14/47
Filed: 2020-05-08
Abstract: The invention provides peptides capable of inhibiting the individual activity and inter-pathway communication of BNIP3, BAX and mitochondria. The peptides can be used in methods of treating a disease or condition in a subject in which it is desirable to prevent cell damage and cell death.
Patent WO-2020239464-A1 (WO)
Title: Lèvre d'entrée d'air de nacelle d'aéronef comportant au moins une source d'émission d'infrarouges
Inventor: GONIDEC PATRICK
IPC: B64D29/00
Filed: 2020-05-14
Abstract: Une lèvre (2a) d'entrée d'air d'une nacelle de turbomachine (1) d'aéronef s'étendant selon un axe X dans lequel circule un flux d'air (F) d'amont vers l'aval, la lèvre (2a) s'étendant de manière annulaire autour de l'axe X et comportant une paroi intérieure (21) tournée vers l'axe X et une paroi extérieure (22) qui est opposée à la paroi intérieure (21), la paroi intérieure (21) et la paroi extérieure (22) étant reliées par une paroi amont (23) et une cloison (25) de manière à délimiter une cavité annulaire (24) dans laquelle est logée au moins une source d'émission d'infrarouges (9), au moins une paroi, choisie parmi la paroi intérieure (21), la paroi extérieure (22) et la paroi amont (23), est réalisée dans un matériau configuré pour transmettre sur une face externe au moins 30% des infrarouges reçus sur une face interne.
Patent WO-2020239788-A1 (WO)
Inventor: STAUDT MARKUS
IPC: F02D41/28
Filed: 2020-05-26
Abstract: L'invention concerne un procédé de contrôle d'un injecteur (7) pour détecter des endommagements mécaniques, dans lequel, à partir d'une pression d'accumulation individuelle (pE), un écart entre la valeur de consigne et la valeur réelle d'un point de travail de l'injection est déterminé, à partir d'une pluralité d'écarts entre la valeur de consigne et la valeur réelle des points de travail, une fonction abstraite, en particulier une répartition normale de Gauss est calculée, la fonction abstraite étant comparée à un modèle d'endommagement prédéfini, à l'aide de la comparaison, une cause de l'usure étant attribuée et le fonctionnement de l'injecteur (7) se poursuivant sur la base de la comparaison.
Patent WO-2020239815-A1 (WO)
Title: Quick attachment clamp for external fixation systems
Inventor: VENTURINI DANIELE
IPC: A61B17/64
Filed: 2020-05-27
Abstract: A clamp (1) for an external fixator, preferably of the quick attachment type, comprising: at least one first attachment (2) provided with at least one bar housing seat (26) for a bar of the external fixator and/or with at least one screw housing seat (23a, 23b) for a bone screw; at least one second attachment (3) provided with at least one bar housing seat (36); a connector (5) which, in a tightened configuration, passes through said first attachment (2) and said second attachment (3) locking the bars and/or bone screws within the bar housing seats (26, 36) and/or the screw housing seats (23a, 23b); and which, in an open configuration, frees the entrance to at least the bar housing seat (36) of said second attachment (3); and auxiliary connection means (4) between said first attachment (2) and said second attachment (3) which are active in said open configuration.
Patent WO-2020249397-A1 (WO)
Inventor: HEMPERT FABIAN
IPC: H02J1/14
Filed: 2020-05-27
Abstract: Es wird ein Verfahren zur Begrenzung eines Laststromes in einer Versorgungsleitung beschrieben, die eine erste Last mit elektrischem Strom versorgt, mit den Schritten: - Festlegen eines ersten Zeitintervalls und eines zweiten Zeitintervalls (S1), wobei das erste Zeitintervall nach einem Zuschaltzeitpunkt der ersten Last zu der Versorgungsleitung (T0) beginnt und das zweiten Zeitintervall später als das erst Zeitintervall beginnt; - Begrenzen des Laststromes innerhalb des ersten und zweiten Zeitintervalls auf einen ersten Wert (I1) (S2); - Begrenzen des Laststromes, zumindest am Ende des zweiten Zeitintervalls (T3)(S3), auf einen zweiten Wert (I2), wobei der zweite Wert (I2) kleiner als der erste Wert (I1) ist.
Patent WO-2020240020-A1 (WO)
Title: Modular sample processing device
Inventor: COFFEY LEE
IPC: B01L3/00
Filed: 2020-05-29
Abstract: Broadly speaking, embodiments of the present techniques provide a modular sample processing device which allows a user to perform any number of biological processes within a single device, in the order the user requires. The device is customisable – a user may select two or more modules and connect them in series to form the device in which the biological processing takes place. Advantageously, this may enable a user to perform multiple processes within a single device and potentially outside of a laboratory (e.g. during field work) or outside of sterile/aseptic environments. Furthermore, the device is a hand-held device, which means the device is compact and easy to transport and use for field work.
Patent WO-2020249433-A1 (WO)
Inventor: LAEMMERHOLD KAI
IPC: C08G64/42
Filed: 2020-06-03
Abstract: The invention relates to a method for preparing polyether carbonate polyols by means of the following steps: (i) adding alkylene oxide and carbon dioxide onto an H-functional starter substance in the presence of a double metal cyanide catalyst or a metal complex catalyst based on the metals zinc and/or cobalt to obtain a reaction mixture containing the polyether carbonate polyol, (ii) introducing at least one component K to the reaction mixture containing the polyether carbonate polyol, characterised in that the component K is at least one compound selected from the group consisting of monocarboxylic acids, polycarboxylic acids, hydroxycarboxylic acids and vinylogous carboxylic acids, wherein compounds containing a phosphorus-oxygen bond or compounds of phosphorus that can form one or more P-O bonds through reaction with OH-functional compounds, and acetic acid are excluded from component K.
Patent WO-2021001201-A1 (WO)
Title: Verfahren und vorrichtung zum betreiben einer antriebsanordnung eines kraftfahrzeugs, antriebsanordnung
Inventor: KREIDEL TIM
IPC: H02P21/02
Filed: 2020-06-23
Abstract: Die Erfindung betrifft ein Verfahren zum Betreiben einer eine elektrische Maschine (3) aufweisenden Antriebsanordnung (2) eines Kraftfahrzeugs (1), wobei der elektrischen Maschine (3) in Abhängigkeit von einer Drehmomentanforderung ein Soll-Drehmoment vorgegeben wird, und wobei eine Ist-Drehzahl (ωEM) der elektrischen Maschine (3) überwacht und in Abhängigkeit von der erfassten Ist-Drehzahl eine Drehzahlschwingung (ωOsc) der elektrischen Maschine (3) bestimmt und das Soll-Drehmoment mit einem in Abhängigkeit von der Drehzahlschwingung (ωOsc) ermittelten Kompensationsdrehmoment (TD) überlagert wird. Es ist vorgesehen, dass die Drehzahlschwingung (ωOsc) der Ist- Drehzahl (ωEM) bestimmt wird unter Verwendung eines mehrdimensionalen Reglers (11) mit einem Zweimassenschwingmodell, einem Ist-Drehmoment (TEM) der elektrischen Maschine (3) und der Ist-Drehzahl (ωEM) der elektrischen Maschine (3).
Patent WO-2021008890-A1 (WO)
Inventor: KORNAU HANS-CHRISTIAN
IPC: C07K14/705
Filed: 2020-07-02
Abstract: The invention relates to a soluble N-methyl-D-aspartate receptor (NMDAR) protein construct comprising one or more NMDAR autoantibody epitopes, wherein the construct comprises an extracellular domain (ECD) of the NMDAR subunit GluN1 or a fragment thereof and an ECD of at least one of the NMDAR subunits GluN2A, GluN2B, GluN2C or GluN2D, or fragment thereof. Further, the invention relates to an in vitro method for the detection of NMDAR autoantibodies in a sample, the method comprising, a.) providing a sample suspected of comprising NMDAR autoantibodies, b.) providing a NMDAR protein construct of the invention as a capture molecule, c.) contacting said sample with said NMDAR protein construct, thereby binding NMDAR autoantibodies from said sample to said NMDAR protein construct, and d.) determining the presence and optionally the amount of bound NMDAR autoantibodies. In embodiments, the method of the invention is applied for the diagnosis, prognosis, disease monitoring, patient stratification and/or therapy monitoring of a medical condition associated with autoantibodies against the NMDAR, preferably anti-NMDAR encephalitis.
Patent WO-2021013600-A1 (WO)
Inventor: LAY REINER
IPC: B60S1/38
Filed: 2020-07-13
Abstract: L'invention concerne un balai d'essuie-glace (10), en particulier pour une vitre (30) d'un véhicule à moteur. Ledit balai d'essuie-glace comprend un raidisseur (12) sur lequel est disposé un moyen de retenue (14) destiné à être fixé sur un bras d'essuie-glace. Ledit balai comprend en outre une lame d'essuyage (18) et un élément de liaison basculant (16). Selon l'invention, l'élément de liaison basculant (16) est fixé à la lame d'essuyage (18) par complémentarité de forme et est également fixé au raidisseur (12), le raidisseur (12) étant ainsi relié à la lame d'essuyage (18).
Patent WO-2021038007-A1 (WO)
Title: Method for estimating the temperature rise rate of a battery under pulsed heating
Inventor: QIN YUDI
IPC: H01M10/635
Filed: 2020-08-27
Abstract: The present application relates to a method for estimating the temperature rise rate of a battery under pulsed heating. By establishing an equivalent circuit model of the battery, parameters in the equivalent circuit model of the battery are identified to obtain the effective entropy potential of the battery and the relationship between the open circuit voltage and the pulsed heating current of the battery. The amplitude and period of the pulsed heating current are pulsed parameters. Then according to the effective entropy potential and the relationship between the open circuit voltage and the pulsed heating current of the battery, a heat generation model is established. By using the heat generation model and the heat transfer power of the battery, an energy formulation of the battery in the process of pulsed heating is obtained, so as to obtain the temperature rise rate of the battery under pulsed heating. By establishing an equivalent circuit model of the battery and using the heat generation model of the battery and the heat transfer power model of the battery, the foregoing method can obtain the relationship between the temperature rise rate of the battery under pulsed heating and the pulsed heating current, providing a convenient and comprehensive estimation method for determining the heating effect of pulsed heating in practical applications.
Patent WO-2022042854-A1 (WO)
Title: A method of programming a software module associated with a firmware unit of a device
Inventor: OLLITERVO SAKARI
IPC: G06F8/30
Filed: 2020-08-28
Abstract: The current disclosure describes a method of programming a software module associated with a firmware unit of a device. The method comprises obtaining a register transfer level pro- gram associated with the firmware unit, the register transfer level program comprising a plurality of register variables indicative of a plurality of registers in the firmware unit, defined within a first namespace of the register transfer level program; and linking the first namespace associated with the register transfer level program with a namespace as- sociated with a software module for referencing at least one of the register variable from the plurality of register vari- ables. The register transfer level program includes design level description of one or more operations associated with the firmware unit in a high-level programming language.
Patent WO-2021043946-A1 (WO)
Title: Blade access arrangement for a rotor blade of a wind power plant
Inventor: JUNKER PETER MOOS
IPC: F03D80/50
Filed: 2020-09-03
Abstract: Blade access arrangement for a rotor blade of a wind power plant A blade access arrangement (1) for a rotor blade (2) of a wind power plant having a tower (4) is described, the arrangement (1) comprising a platform (10) having blade guide means (12, 13) for guiding the platform against the blade and tower guide means (14) for guiding a platform (10) against the tower. Such a blade access arrangement should allow a safe access to the blade. To this end the platform 10 is adjustable in an open configuration, in which the blade can enter the blade guide means, (12, 13), and in a closed configuration, in which the platform (10) is guided by the blade (2).
Patent WO-2021089267-A1 (WO)
Inventor: REHME OLAF
IPC: F04B53/14
Filed: 2020-10-07
Abstract: Die Erfindung betrifft ein Verfahren zum Herstellen eines Kolbens (100). Um die Nachteile eines als reines Gussprodukt ausgestalteten Kolbens (100) zu überwinden und dabei wirtschaftlich und zeitlich optimal zu fertigen wird vorgeschlagen, dass der Kolben folgende Merkmale aufweist: - eine innere Struktur (110), die zur Aufnahme und/oder Befestigung eines Pleuels und/oder einer Stange (200) ausgebildet ist, - eine äußere Struktur (130), die eine Mantelfläche (131) sowie eine Endfläche (132) aufweist, und - eine Zwischenstruktur (120), die die innere Struktur (110) mit der äußeren Struktur (130) verbindet und zumindest teilweise additiv gefertigt ist.
Patent WO-2021078776-A1 (WO)
Title: Thermal fluid flow sensor
Inventor: UDREA FLORIN
IPC: G01F1/684
Filed: 2020-10-21
Abstract: We disclose herein a flow and thermal conductivity sensor comprising a semiconductor substrate comprising an etched portion, a dielectric region located on the semiconductor substrate, wherein the dielectric region comprises at least one dielectric membrane located over the etched portion of the semiconductor substrate and a heating element located within the dielectric membrane. The dielectric membrane comprises one or more discontinuities located between the heating element and an edge of the dielectric membrane.
Patent WO-2021089791-A1 (WO)
Inventor: CALVAYRAC OLIVIER
IPC: A61K31/4184
Filed: 2020-11-06
Abstract: Resistance to kinase inhibitors exemplifies the greatest hindrance to effective treatment of cancer patients. Recent studies have suggested that the onset of said resistance might not only be explained by a drug selection of pre-existing resistant sub-clones as it what was generally assumed, but may also arise de novo from a small population of drug-tolerant cells (DTC) that initially resists the treatment by entering a slow cycling state. Thus, targeting these DTC should be a new promising approach to hamper the emergence of secondary resistance to kinase inhibitors. The inventors now demonstrate that farnesyltransferase (but not geranylgeranyl transferase) inhibition can prevent the emergence of said resistance in different oncogenic contexts. In particular, the inventors determined in vitro the efficacy of farnesyltransferase inhibitor (i.e. Tipifarnib) in combination with erlotinib in several EGFR-mutated cell lines. They showed that the combination efficiently eliminated all drug tolerant cells, and fully prevented the emergence of resistant clones. Interestingly, similar results were observed in other oncogenic models such as ALK-translocated lung cancer cells or BRAF-mutated melanoma cells. Thus the present invention relates to use of farnesyl transferase inhibitors for the treatment of cancers that have acquired resistance to kinase inhibitors.
Patent WO-2021089845-A1 (WO)
Inventor: OCHSENBEIN ADRIAN
IPC: A61K31/5415
Filed: 2020-11-06
Abstract: The present invention relates to compounds of formula (1): Ar-L-N(R 1 )(R 2 ), for use in the treatment of cancer. The compounds of formula (1) are characterized by a mono-, bi- or tricyclic aryl or heteroaryl (Ar) and a basic nitrogen atom with R 1  and R 2  being a linear alkyl or forming an aliphatic or heterocyclic ring. The aryl or heteroaryl and the basic nitrogen atom are connected via a linker L. The compounds of formula (1) are potent inhibitors of CD93, particularly of the CD93 intracellular domain.
Patent WO-2021094420-A1 (WO)
Title: Verwendung eines anschlussgehäuses
Inventor: KURZ RALF
IPC: H02G9/10
Filed: 2020-11-12
Abstract: Die Erfindung betrifft eine Verwendung eines Anschlussgehäuses (2), welches einen Gehäuseinnenraum (4) begrenzt, der über eine Öffnung (5) in dem Anschlussgehäuse (2) zugänglich ist, bei welcher Verwendung i) das Anschlussgehäuse (2) solchermaßen in einen Boden (35) eingebaut wird, dass der Gehäuseinnenraum (4) von oben über die Öffnung (5) in dem Anschlussgehäuse (2) zugänglich bleibt; ii) in dem Boden ein Datenkabel (31) zu dem Anschlussgehäuse (2), also in dessen Gehäuseinnenraum (4) hineinverlegt wird; iii) das in den Gehäuseinnenraum (4) hineinverlegte Datenkabel (31) an ein Funkmodul (30) mit einer Antenneneinheit (30.1) angeschlossen wird; iv) zumindest die Antenneneinheit (30.1) solchermaßen an dem Anschlussgehäuse (2) montiert wird, dass sie oberhalb des Gehäuseinnenraums (4) angeordnet ist und von dem Anschlussgehäuse (2) als Sockel (33) getragen wird.
Patent WO-2021129976-A1 (WO)
Title: Méthode de diagnostic de maladies cutanées liées au lymphome t
Inventor: NESTOROV PETER
IPC: G01N33/50
Filed: 2020-11-13
Abstract: La présente invention concerne une méthode de diagnostic du syndrome de Sézary ou du mycosis fongoïde chez un sujet. La présente invention concerne également une méthode permettant de déterminer la fréquence des cellules de signature Sézary et/ou des cellules de mycosis fongoïdes dans un échantillon. En outre, la présente invention concerne une méthode mise en œuvre par ordinateur comprenant un algorithme classificateur pour déterminer la fréquence des cellules de signature Sézary et/ou des cellules de mycosis fongoïdes. En outre, la présente invention concerne un échantillonnage de biomarqueurs qui peut être utilisé pour le diagnostic du syndrome de Sézary ou du mycosis fongoïde.
Patent WO-2021122501-A1 (WO)
Inventor: ESCALIER THIBAULT
IPC: A47J31/02
Filed: 2020-12-15
Abstract: A machine for preparing a beverage has a beverage processing unit (10,20) formed of a first processing unit member (10) and a second processing unit member (20) that delimit a chamber (21) and that are movable between a distant configuration in which a flavouring ingredient (2) is received in the chamber (21) and a proximate configuration in which the flavouring ingredient (2) is held and mixed with water (4). The machine has a beverage collector (80) for collecting the beverage (3) from the processing unit (10,20). The collector (80) has a collecting wall (81) directing the beverage (3) out of the collector (80) to a beverage dispensing area (90). The machine has: a water source for delivering the water (4) towards the processing unit (10,20); a water guide (30) for guiding the water (4) between the water source and the chamber (21); and a supporting structure (70) which has a base (72) that supports the beverage collector (80) during beverage preparation. The beverage processing unit (10,20) and/or the beverage collector have a peripheral upright drainage wall (13) external to the chamber (21) and extending at least partly about the chamber (21) for collecting the beverage (3) outside the chamber (21) after the beverage (3) has exited the chamber (21) via at least one outlet (12). The beverage collecting wall (81) extends below a bottom part of the drainage wall (13) and right underneath the processing unit (10,20) to collect the beverage (3) when draining off from the drainage wall (13) and to direct the beverage (3) from the collecting wall (81) out of the collector (80).
Patent WO-2021170303-A1 (WO)
Inventor: HELLER MICHAEL
IPC: G05B13/04
Filed: 2021-01-13
Abstract: Die Erfindung betrifft ein Verfahren zum Bereitstellen von Prozessdaten eines Geräts ( 100 ) in einer industriellen Automatisierungsumgebung an ein Computersystem ( 200 )· Das Verfahren umfasst in einer Ausführungsform die folgenden Schritte: Ausführen (S 15 ) eines Prozessdatenmodells ( 400 ) auf dem Gerät ( 100 ) zum Erzeugen von geschätzten Prozessdaten (D 200 ); Bestimmen (S 20 ), dass die geschätzten Prozessdaten (D 200 ) um mehr als einen Schwellwert von realen Prozessdaten (D 100 ) abweichen; und nur dann, wenn die geschätzten Prozessdaten (D 200 ) um mehr als den Schwellwert von den realen Prozessdaten (D 100 ) abweichen: Übertragen (S 25 ) von Informationen, welche die realen Prozessdaten (D 100 ) repräsentieren, von dem Gerät ( 100 ) zu dem Computersystem ( 200 ).
Patent WO-2022223109-A1 (WO)
Title: Coordinating management of a plurality of cells in a cellular communication network
Inventor: JEONG JAESEONG
IPC: H04W24/02
Filed: 2021-04-21
Abstract: A computer implemented method (100) is disclosed for coordinating management of a plurality of cells in a cellular communication network, wherein each of the plurality of cells is managed by a respective Agent. The method comprises assembling a candidate set of cells (110), wherein each cell in the candidate set is awaiting execution of an action selected for the cell by its managing Agent. The method further comprises selecting a cell from the candidate set (120), adding the selected cell to an execution set of cells (130), and removing, from the candidate set of cells, the selected cell and all cells identified in a topology graph of the plurality of cells as fulfilling an interference condition with respect to the selected cell (140). The method further comprises, if a scheduling condition is fulfilled, initiating, for all cells in the execution set of cells, execution of the actions selected for the cells by their managing agents (150).
Patent WO-2021214335-A1 (WO)
Inventor: VAN DEN BOSSCHE JOHAN
IPC: A61B5/00
Filed: 2021-04-23
Abstract: The present invention relates to a monitoring device (1) for monitoring the fluid balance of an animal or human body. The device comprises a body weight sensor (2) for continuously or periodically weighing the body, a fluid delivery device (3) for providing a controllable supply of fluid to the body, a urine output sensor (4) for determining the urine output of the body, a processor (5). The processor (5) is adapted for determining a total fluid outtake of the body and a fluid outtake due to perspiration and respiration by taking a signal provided by the body weight sensor (2) and a signal provided by the urine output sensor (4) into account, and providing a control signal to the fluid delivery device (3) to regulate a volume, flow velocity or flow rate of the fluid delivered to the body, so as to maintain a predetermined fluid balance in the body.
Patent WO-2021224356-A1 (WO)
Inventor: BERGER PATRICK
IPC: A61P11/00
Filed: 2021-05-05
Abstract: La présente invention concerne une nouvelle composition à utiliser dans un procédé de traitement de la COVID-19, comprenant l'administration à un patient d'une quantité thérapeutiquement efficace d'au moins un antagoniste ou inhibiteur du récepteur chimiokine CXCR4.
Patent WO-2021250062-A1 (WO)
Inventor: PALO DANIEL
IPC: B60R19/18
Filed: 2021-06-09
Abstract: The present invention relates to a vehicle bumper beam (12) for attachment to a vehicle body, which bumper beam is extending generally horizontally when attached to a vehicle body, said bumper beam having a generally U-shaped section, providing a central portion (14) and side walls (16); wherein at least one local area (24) of at least one side wall (16) is provided with reduced tensile strength in comparison to major portions of said bumper beam, and wherein said at least one local area (24) with reduced tensile strength is placed adjacent attachment points (20, 22) for the bumper beam to the vehicle body.
Patent WO-2021250226-A1 (WO)
Inventor: BALBOA JAVIER
IPC: C07K14/435
Filed: 2021-06-11
Abstract: The present invention relates novel cyclic peptides which can act as inhibitors of protein-protein interactions, specifically by inhibiting the PDZ2 domain of PSD-95, as well as their use in treatment of excitotoxic-related diseases and neuropathic pain.