Patent GB-697492-A (GB)
Title: Drain-clear container for aqueous-vehicle liquid pharmaceutical preparations
Inventor: ROSENBLUM HAROLD
IPC: B65D23/02
Filed: 1951-04-16
Abstract: Pharmaceutical containers such as vials, bottles, ampoules, hypodermic syringes, pipettes and burettes are given a thin transparent film of a silicone anti-wetting agent and a silicone antifoam agent so that they drain better.  Satisfactory silicone anti-wetting agents are of the formula SinOn-1R2n+2, where n is an integral number and R is any single alkyl or aryl group or combination thereof.  The alkyl groups may be saturated or unsaturated, such as methyl, ethyl, propyl, butyl, amyl, hexyl, heptyl, octyl, decyl, dodecyl, vinyl, or allyl, and the aryl groups may be phenyl, toluyl or naphthyl.  Examples are hexamethyl disiloxane (CH3)6Si2O, dodecamethyl pentasiloxane (CH3)12Si5O4, and methylphenylpolysiloxane (CH3)x(C6H5)(2n+2)-n SinOn-1 where x is any integral number less than 2n+2.  Satisfactory silicone antifoam agents are a mixture of alkyl silicones as described above and an unsubstituted silica, a commercial example being D.C. antifoam A which is a physical mixture of methyl polysiloxane (specific gravity 0.95 plus or minus 0.05) and finely divided silica.  The silicone anti-wetting agent and silicone antifoam agent are dissolved in an organic solvent such as chloroform or ether and introduced into the container to leave a film thereon.  The solvent is allowed to evaporate preferably under heat treatment which bakes the residual film.  An example is 1 part by weight of methylsilicone, fluid viscosity 50 centistokes 0.1 parts by weight of D.C. antifoam A, enough chloroform to make up 100 parts by weight of D.C. antifoam A, enough chloroform to make up 100 parts by weight.  A suitable baking time is half-an-hour at 300 DEG  C., or nine hours at 180 DEG  C. Satisfactory results have been obtained with as little as 0.0005 to 0.2 parts by weight of D.C. antifoam A.ALSO:Pharmaceutical containers such as vials, bottles, ampoules, hypodermic syringes, pipettes and burettes are given a thin transparent film of a silicone anti-wetting agent and a silicone antifoam agent so that they drain better. Satisfactory silicone anti-wetting agents are of the formula Sin On-1 R2n+2 where n is any integral number and R is any single alkyl or aryl group or combination thereof.  The alkyl groups may be saturated or unsaturated, such as methyl, ethyl, propyl, butyl, amyl, hexyl, heptyl, octyl, decyl, dodecyl, vinyl, or allyl, and the aryl groups may be phenyl, toluyl or naphthyl. Examples are hexamethyl disiloxene (CH3)6Si2O, dodecamethyl pentasiloxane (CH3)12Si5O4, and methylphenylpolysiloxane (CH3)x(C6H5) (2n+2-xSinOn-1 where x is any integral number less than 2n+2.  Satisfactory silicone antifoam agents are a mixture of alkyl silicones as described above and an unsubstituted silica, a commercial example being DC antifoam A which is a physical mixture of methyl polysiloxane (specific gravity 0.95 plus or minus 0.05) and finely divided silica.  The silicone anti-wetting agent and silicone antifoam agent are dissolved in an organic solvent such as chloroform or ether and introduced into the container to leave a film thereon.  The solvent is allowed to evaporate preferably under heat treatment which bakes the residual film.  An example is 1 part by weight of methylsilicone, fluid viscosity 50 centistokes, 0.1 parts by weight of DC antifoam A, enough chloroform to make up 100 parts by weight A suitable baking time is half an hour at 300 DEG C, or nine hours at 180 DEG C. Satisfactory results have been obtained with as little as 0.0005 to 0.2 parts by weight of DC antifoam A.ALSO:Pharmaceutical containers such as vials, bottles, ampoules, hypodermic syringes, pipettes and burettes are given a thin transparent film of a silicone anti-wetting agent and a silicone antifoam agent so that they drain better. Satisfactory silicone anti-wetting agents are of the formula SinOn-1R2n+2 where n is any integral number and R is any single alkyl or aryl group or combination thereof.  The alkyl groups may be saturated or unsaturated, such as methyl, ethyl, propyl, butyl, amyl, hexyl, heptyl, octyl, decyl, dodecyl, vinyl, or allyl, and the aryl groups may be phenyl, toluyl or naphthyl.  Examples are hexamethyl disiloxane (CH3)6Si2O, dodecamethyl pentasiloxane (CH3)12Si5O4, and methylphenylpolysiloxane (CH3)x(C6H5)(2n+2)-x SinOn-1 where x is any integral number less than n+2.  Satisfactory silicone antifoam agents are a mixture of alkyl silicones as described above and an unsubstituted silica, a commercial example being DC antifoam A which is a physical mixture of methyl polysiloxane (specific gravity 0.95 plus or minus 0.05) and finely divided silica.  The silicone anti-wetting agent and silicone antifoam agent are dissolved in an organic solvent such as chloroform or ether and introduced into the container to leave a film thereon.  The solvent is allowed to evaporate preferably under heat treatment which bakes the residual film.  An example is 1 part by weight of methylsilicone (fluid viscosity 50 centistokes) 0.1 parts by weight of DC antifoam A, enough chloroform to make up 100 parts by weight.  A suitable baking time is half an hour at 300 DEG  C., or nine hours at 180 DEG  C. Satisfactory results have been obtained with as little as 0.0005 to 0.2 parts by weight of DC antifoam A.