Patent SG-11201908351T-A (SG)
Title: Indole derivatives as efflux pump inhibitors
Inventor: LAVOIE EDMOND J
IPC: C07D401/04
Filed: 2018-03-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIPO I PCT 0111111010 0111 °nolo mu IIIII Em OH oinio oimIE (10) International Publication Number WO 2018/165611 Al (51) International Patent Classification: CO7D 403/12 (2006.01) CO7D 401/12 (2006.01) CO7D 401/14 (2006.01) CO7D 405/04 (2006.01) A61K 31/404 (2006.01) C07D 209/42 (2006.01) C07D 401/04 (2006.01) A61P 31/04 (2006.01) (21) International Application Number: PCT/US2018/021848 (22) International Filing Date: 09 March 2018 (09.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/469,987 10 March 2017 (10.03.2017) US 62/523,154 21 June 2017 (21.06.2017) US (71) Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY [US/US]; Old Queens Building, Som- erset and George Streets, New Brunswick, New Jer- sey 08903 (US). TAXIS PHARMACEUTICALS, INC. [US/US]; 9 Deer Park Drive, Suite J-15, Monmouth Junc- tion, New Jersey 08852 (US). (72) Inventors; and (71) Applicants: LAVOIE, Edmond J. [US/US]; Old Queens Building, Somerset and George Streets, New Brunswick, New Jersey 08903 (US). PARHI, Ajit [US/US]; Old Queens Building, Somerset and George Streets, New Brunswick, New Jersey 08903 (US). YUAN, Yi [CN/US]; 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852 (US). ZHANG, Yongzheng [US/US]; 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852 (US). SUN, Yangsheng [US/US]; 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852 (US). (74) Agent: MICKELSON, John W. et al.; 7851 Metro Park- way, Suite 325, Bloomington, Minnesota 55425 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) = (54) Title: INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS (57) : Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of for- mula I for use in treating or preventing bacterial infections. (I) W O 20 18/ 165 6 11 Al