baber/WOPTO huggingface dataset:
Patent AU-729348-B2 (AU)
Title: 6-O-substituted ketolides having antibacterial activity
Inventor: OR YAT SUN
IPC: A61K31/70
Filed: 1997-09-02
Granted: 2001-02-01
Abstract: 6-Substituted ketolides of e.g. formula (II) or (III), and their salts, esters and prodrugs are new: Y + Z = X; X = OH, =NOR1 or =NOC(R5)(R6)OR1; or one of Y and Z = H; and the other = H, OH, protected OH or NR7R8; R1 = 1-12C alkyl (optionally substituted), 3-12C cycloalkyl or SiR2R3R4; R2-R4 = 1-12C alkyl or aryl; R5, R6 = H or 1-12C alkyl (optionally substituted), or R5 + R6 = 3-12C cycloalkyl; R7, R8 = H or 1-6C alkyl; or NR7R8 = 3-7 membered ring which, when the ring is 5-7 membered may optionally contain O, NH, N(1-6C alkyl), N(aryl), N(aryl-1-6C alkyl), N (substituted aryl-1-6C alkyl), N(heteroaryl), N(heteroaryl-1-6C alkyl), N(substituted heteroaryl-1-6C alkyl), S or S(O)n; n = 1 or 2; Ra = H or OH; Rc = H or hydroxy protecting group; R9 = 1-6C alkyl (optionally substituted), 3-7C cycloalkyl or optionally substituted aryl or heteroaryl; M = CONH, NHCO, NH, N=, NMe, NHCOO, NHCONH, OCONHY, OCOO, O, S(O)n, COO, OCO or CO; R = methyl (substituted by CN, F, CO2R10, S(O)nR10, NHCOR10, NHCONR11R12, aryl, substituted aryl, heteroaryl or substituted heteroaryl); 2-10C alkyl (optionally substituted), 3C alkenyl (substituted by halo, CHO, CO2R10, COR9, CONR11R12, CN, optionally substituted aryl or heteroaryl, 3-7C cycloalkyl or 1-12C alkyl substituted by heteroaryl); 4-10C alkenyl (optionally substituted), or 3-10C alkynyl optionally substituted); R10 = 1-3C alkyl (optionally aryl substituted), or heteroaryl substituted 1-3C alkyl; R11, R12 = H or 1-3C alkyl (optionally substituted); A, B, D, E = H, 1-6C alkyl (optionally substituted by optionally substituted), 3-7C cycloalkyl, optionally substituted aryl or heteroaryl, heterocycloalkyl or 1-6C alkyl substituted by MR9; provided that \- 2 of A, B, D and E = H; or any one pair of substituents, consisting of AB, AD, AE, BD, BE or DE taken with the atoms to which they are attached, form a 3- to 7-membered ring optionally containing O, NH, N(1-6C alkyl), N(aryl-1-6C alkyl), N(substituted aryl-1-6C alkyl), N(heteroaryl-1-6C alkyl), N(substituted heteroaryl-1-6C alkyl), S, S(O)n, CONH, CONR12, NHCO, NR12CO or C(=NH)NH.
Patent AU-763269-B2 (AU)
Title: Collecting and reporting monitoring data from remote network probes
Inventor: WOLF JAY B
IPC: H04L12/26
Filed: 2000-04-10
Granted: 2003-07-17
Abstract: A method for collecting and reporting monitored data for network traffic, which has been accumulated by a plurality of remote probes. The method includes making a series of polling requests for lists of monitoring data to each probe and receiving the requested lists. Each list has traffic count values that are identified by at least a sampling time, a source address, a destination address and a probe identifier. The method also includes calculating the traffic observed by each probe between successive sampling times and apportioning the calculated traffic data among a single set of consecutive temporal intervals and selecting best counts to avoid overcounting.
Patent AU-723399-B2 (AU)
Title: Hydraulic system for manoeuvring boats, ships and crafts in general
Inventor: RISI FELICE DE
IPC: B63H25/42
Filed: 1997-11-14
Granted: 2000-08-24
Abstract: PCT No. PCT/IT97/00279 Sec. 371 Date Jul. 2, 1998 Sec. 102(e) Date Jul. 2, 1998 PCT Filed Nov. 14, 1997 PCT Pub. No. WO98/22337 PCT Pub. Date May 28, 1998A hydraulic system for the control of boats, ships and crafts in general that comproses nozzles (1, 2) opposed and the end of the stem, having a Venturi tube throttling (8) or an internal diameter reduced by means of flanges (10), so as to be able to determine, following to the outlet of the fluid under pressure, the movement by reaction of the front part of the boat (N) and therefore to perform immediate leftward or rightward curvings according to the nozzle used, and/or corresponding nozzles (3, 4), placed nearby the stern and with similar background function, while the operating the hydraulic reaction of both nozzles placed on the same side determines the parallel movement on the whole craft, for moming alongside to quays or for performing other maneuvers.
Patent AU-780409-B2 (AU)
Title: High throughput functional genomics
Inventor: HICKMAN JAMES J
IPC: C12M1/34
Filed: 2000-05-22
Granted: 2005-03-17
Abstract: The system of the invention analyzes <i>how</i> the action potential is interrupted by drugs or toxins. Differences in the action potentials are due to individual toxins acting on different biochemical pathways, which in turn affects different ion channels, thereby changing the peak shape of the action potential differently for each toxin. Algorithms to analyze the action potential peak shape differences are used to indicate the pathway(s) affected by the presence of a new drug or compound; from that, aspects of its function in that cell are deduced. This observation can be exploited to determine the functional category of biochemical action of an unknown compound. An important aspect of the invention is surface chemistry that permits establishment of a high impedance seal between cell and a metal microelectrode. This seal recreates the interface that enables functional patch-clamp electrophysiology with glass micropipettes, and allows extracellular electrophysiology on a microelectrode array.
Patent AU-707702-B2 (AU)
Title: System for jointing panels
Inventor: WATSON WILLIAM BLACK
IPC: E04D3/366
Filed: 1996-03-22
Granted: 1999-07-15
Abstract: PCT No. PCT/GB96/00701 Sec. 371 Date Sep. 19, 1997 Sec. 102(e) Date Sep. 19, 1997 PCT Filed Mar. 22, 1996 PCT Pub. No. WO96/29486 PCT Pub. Date Sep. 26, 1996A system for joining a first panel (2) and a second panel (3) overlying a support structure (4) comprising a retaining member (8) fixable to the support structure (4) and having a portion adapted to retain a side (6) of said first panel (2) and a cap member (9) configured substantially to enclose said retaining member (8), wherein said cap member (9) has an inwardly directed projection (14, 15) for retaining the cap member and wherein said cap member (9) is perforated.
Patent AU-589411-B2 (AU)
Title: Two-loop line deflection system
Inventor: WILLIS DONALD HENRY
IPC: H04N5/12
Filed: 1986-03-25
Granted: 1989-10-12
Abstract: In a synchronized digital horizontal deflection system operating at 2xfH, a digital phase-lock-loop circuit generates first fH rate signal that is synchronized to the horizontal sync pulses, and a second fH rate second signal that is delayed from the first signal by one-half of the period H. A digital phase-control-loop circuit receives the first and second signals and generates a horizontal deflection control signal at 2xfH rate that controls the retrace interval timing in a deflection circuit output stage. The synchronization of every other retrace interval occur in accordance with information provided by the first signal.
Patent AU-567635-B2 (AU)
Title: Apparatus to produce croissants
Inventor: UENO SADAO
IPC: A21C3/06
Filed: 1986-05-22
Granted: 1987-11-26
Abstract: @ An apparatus and method for producing croissant dough rolls is provided. Dough pieces (37) are fed between two endless belt devices (5, 7) in which the belts (2, 4) move in opposite directions, and rolled up. Means is provided to adjust the gap(H) between the two belts so as to decrease the gap to roll up the forward end of a dough piece and to increase the gap to permit a smooth rolling up operation. A pair of rollers (39, 41) may be provided adjacent the upstream ends of the endless belt devices to hold the dough pieces, thereby assisting the belt devices in their effective rolling up operation.
Patent AU-641665-B2 (AU)
Title: Novel stereoisomers
Inventor: ALMGREN KNUT OLLE SEVED
IPC: A61K31/275
Filed: 1990-06-19
Granted: 1993-09-30
Abstract: 4-[3-[ethyl[3-((R*)-(propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy] -benzo n itrile, 4-[3-[ethyl[3-((S*)-(propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy] -benz on itrile, 4-[3-[ethyl[3-((R*)-(propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy] -benz on itrile, 4-[3-[ethyl[3-[((S*)-(propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy ]-ben zo nitrile and pharmaceutically acceptable salt thereof, processes for their preparation, as well as the use of said compounds for the preparation of medicaments with action against cardiac arrhythmias.
Patent AU-583402-B2 (AU)
Title: Method for the production of a macromolecular carrier loaded with a biologically active substance
Inventor: MASQUELIER MICHELE
IPC: A61K47/44
Filed: 1986-06-17
Granted: 1989-04-27
Abstract: PCT No. PCT/SE86/00291 Sec. 371 Date Feb. 12, 1987 Sec. 102(e) Date Feb. 12, 1987 PCT Filed Jun. 17, 1986 PCT Pub. No. WO86/07539 PCT Pub. Date Dec. 31, 1986.The invention relates to a method for the preparation of a carrier loaded with lipophilic biologically active substance based on reconstituted LDL (Low Density Lipoprotein), wherein (1) LDL is lyophilized in the presence of a protective agent; (2) the lyophilized LDL is extracted with an organic solvent; (3) the biologically active substance solubilized in a solvent is incubated with extracted LDL; the solvent is evaporated and the reconstituted LDL solubilized in an aqueous buffer; the non-incorporated biologically active substance is separated from the LDL-complex, characterized in that in step (1) the protective agent is a monosaccharide, a disaccharide, a water-soluble polysaccharide, a sugar alcohol or a mixture of these and in step (3) optionally the extract obtained during the extraction of the lyophilized LDL is mixed with the lipophilic biologically active substance solubilized in an organic solvent and this mixture is then incubated with the LDL. Preferred protective agents are sucrose, glucose and fructose. The reconstituted LDL obtained by the claimed process have properties similar to native LDL in vitro and in vivo.
Patent AU-541547-B2 (AU)
Title: Method of using motility increasing peptides
Inventor: BICKEL MARTIN
IPC: C07K7/06
Filed: 1980-10-15
Granted: 1985-01-10
Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE The peptide of the formula I A-Tyr-B-C-D-E in which A denotes hydrogen, alkyl, alkenyl, or alkenylcycloalkyl each having up to 7 carbon atoms, an alpha-amino acid or a peptide with 2 or 3 amino acids, preferably of the L-configuration, B denotes an alpha-amino acid or alpha-amino-isobutyric acid, C denotes glycine or azaglycine, D denotes phenylalanine which can be substituted in the benzene nucleus by methyl, methoxy, halogen, nitro or trifluoromethyl, dehydro- or hexahydrophenylalanine, aza- or N-methylphenylalanine, and E denotes (a) -O-R1 R1 denotes a methyl-polyethylene glycol radical having a degree of polymerization of up to about 50, (b) an amino alcohol or an amino acid, which on its part may carry one of the groups defined sub (a). 1. Claims for the Contracting State : AT A process for the preparation of a peptide of the formula I A-Tyr-B-C-D-E in which A denotes hydrogen, alkyl, alkenyl, or alkenylcycloalkyl each having up to 7 carbon atoms, an alpha-amino acid or a peptide with 2 or 3 amino acids, preferably of the L-configuration, B denotes an alpha-amino acid or alpha-amino-isobutyric acid, C denotes glycine or azaglycine, D denotes phenylalanine which can be substituted in the benzene nucleus by methyl, methoxy, halogen, nitro or trifluormethyl, dehydro- or hexahydrophenylalanine, aza- or N-methylphenylalanine, and E denotes a) -O-R1 R1 denotes a methyl-polyethylene glycol radical having a degree of polymerization of up to about 50, b) an amino alcohol or an amino acid, which on its part may carry one of the groups defined sub (a), characterized in that the amino acid sequences of the formula I are prepared by methods of peptide synthesis.
Patent AU-655156-B2 (AU)
Title: Methods for culturing HCV in eukaryotic cells
Inventor: WEINER AMY J
IPC: C12N7/00
Filed: 1990-08-22
Granted: 1994-12-08
Abstract: The present invention is directed to cells that may be used to propagate HCV in culture. The present invention is also directed to viral antigens produced by such cultures, and the use such antigens, for example, in diagnostics.
Patent AU-684503-B2 (AU)
Title: Therapeutic uses of bactericidal/permeability increasing protein products
Inventor: LITTLE ROGER G II
IPC: A61P9/00
Filed: 1994-03-11
Granted: 1997-12-18
Abstract: The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing (BPI) protein products.
Patent AU-775857-B2 (AU)
Title: Absorbent article employing surface layer with continuous filament and manufacturing process thereof
Inventor: MIZUTANI SATOSHI
IPC: A61F13/15
Filed: 2001-08-31
Granted: 2004-08-19
Abstract: Disclosed is an absorbent article having a liquid permeable surface layer, a backing sheet, and an absorbent layer interposed between the surface layer and the backing sheet. The surface layer includes a liquid permeable base and a layer of continuous filaments extending substantially in one direction and disposed on the surface of the base. The continuous filament layer is fixed to the base at a plurality of fixing portions which are spaced apart in the filament extending direction by a given pitch, to thereby form loop portions of the continuous filaments between adjacent fixing portions. The loop portions are raised toward the surface side. <IMAGE>
Patent AU-669070-B2 (AU)
Title: Traction sheave elevator
Inventor: AULANKO ESKO
IPC: B66B11/04
Filed: 1994-06-24
Granted: 1996-05-23
Abstract: The traction sheave elevator comprises an elevator car (1) moving along elevator guide rails (10), a counterweight (2) moving along counterweight guide rails (11), a set of hoisting ropes (3) on which the elevator car and the counterweight are suspended, and a drive machine unit (6) comprising a traction sheave (7) driven by the drive machine and engaging the hoisting ropes (3). The drive machine unit (6) of the elevator is placed in the top part of the elevator shaft (15) and in the horizontal cross-section of the shaft between the vertical projection of the cabin and the shaft wall, whereby the drive machine unit is fixed to a wall or the ceiling of the elevator shaft.
Patent AU-715643-B2 (AU)
Title: Method and device for operating a continuous casting plant
Inventor: PLESCHIUTSCHNIGG FRITZ-PETER
IPC: B21B37/74
Filed: 1996-07-26
Granted: 2000-02-10
Abstract: PCT No. PCT/DE96/01441 Sec. 371 Date Apr. 2, 1998 Sec. 102(e) Date Apr. 2, 1998 PCT Filed Jul. 26, 1996 PCT Pub. No. WO97/04891 PCT Pub. Date Feb. 13, 1997A process for operating a continuous casting plant with a continuous casting machine that has a stationary mold and is connected via a roller table to an equalizing furnace. After establishment of the slab format at the mold outlet, at least the casting parameter of casting speed is set so that the slab, upon entry into the equalizing furnace, has the desired roll temperature of the hot strip to be produced, and the lowest point of the liquid pool is always located in the mouth region of the continuous casting machine. Measures are taken to influence the heat energy content of the slab after it leaves the continuous casting machine.
Patent AU-686157-B2 (AU)
Title: Method and apparatus for controlling sleep disorder breathing
Inventor: AXE JOHN R
IPC: A61M16/00
Filed: 1994-04-14
Granted: 1998-02-05
Abstract: A method and device for controlling sleep disorder breathing utilizes variable multiple level pressures. A pressure source supplies compressed breathable gas at a relatively low pressure to the user's airway. Pressure transducers monitor pressures and convert them into electrical signals. The electrical signals are filtered and processed to extract specific features such as duration and energy levels. If these features exceed selected threshold values for duration and energy level over a minimum period of time, then the microprocessor declares the presence of sleep disorder breathing. If a selected number of these events occur within a selected time period, then the microprocessor adjusts the pressure delivered by the pressure source. If sleep disorder breathing is not detected within a certain time period, then the microprocessor lowers the pressure level gradually. The device and method disclosed in this patent is capable of detecting apnea, hypopnea, and pharyngeal wall vibration. Further, it is able to distinguish between obstructive, central and mixed apnea and hypopnea.
Patent AU-742270-B2 (AU)
Title: Direct expression of peptides into culture media
Inventor: MEHTA NOZAR M
IPC: C12P21/02
Filed: 1998-04-15
Granted: 2001-12-20
Abstract: The present invention relates to a method of producing an amidated peptide product by producing a precursor having a C-terminal glycine using genetically engineered host cells and thereafter converting said glycine to an amino group to produce a peptide amide. A method for direct expression of a peptide product into a culture medium is also provided.
Patent AU-636022-B2 (AU)
Title: New yeast strains with enhanced trehalose content, process to obtain such yeasts and the use of these yeasts
IPC: C12N15/56
Filed: 1991-03-26
Granted: 1993-04-08
Abstract: A transformed yeast is disclosed, comprising at least one gene encoding neutral trehalase or trehalose-6-phosphate synthase which gene has been modified such that it differs from a corresponding wild-type gene encoding neutral trehalase or trehalose-6-phosphate synthase, the yeast having as a result a different trehalose content from the untransformed parent yeast. The sugar resistance and drying resistance of the yeast compared to those of the untransformed strain are thereby improved.
Patent AU-705711-B2 (AU)
Title: Biodegradable, grain protein-based solid articles and forming methods
Inventor: BASSI SUKH
IPC: B29C45/00
Filed: 1996-11-11
Granted: 1999-05-27
Abstract: A method of forming solid, non-edible biodegradable, grain protein-based articles is provided wherein a grain protein formulation is heated to a maximum temperature of up to about 80 DEG  C. to create a substantially homogeneous and flowable mixture which can be formed into biodegradable articles. The formulation includes from about 20-85% by weight of grain protein, from about 5-75% by weight starch, up to about 14% by weight water, from about 10-40% by weight plasticizer, and at least about 0.01 by weight of a reducing agent such as sodium bisulfite for cleaving disulfide bonds present in the grain protein. Optional ingredients such as fillers, fiber, lubricant/mold release agents and colorants can also be used. The formulations can be processed in extrusion or injection molding equipment to create solid articles.
Patent AU-644878-B2 (AU)
Title: Enterically transmitted non-A/non-B hepatitis viral agent and characteristic epitopes thereof
Inventor: REYES GREGORY R
IPC: A61K38/00
Filed: 1991-04-05
Granted: 1993-12-23
Abstract: Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.
Patent AU-775223-B2 (AU)
Title: Converting diploidy to haploidy for genetic diagnosis
Inventor: VOGELSTEIN BERT
IPC: C12Q1/68
Filed: 2000-10-06
Granted: 2004-07-22
Abstract: Detection of mutations associated with hereditary diseases is complicated by the diploid nature of mammalian cells. Mutations present in one allele are often masked by the wild-type sequence of the other allele. Individual alleles can be isolated from every chromosome within somatic cell hybrids generated from a single fusion. Nucleic acids from the hybrids can be analyzed for mutations in an unambiguous manner. This approach was used to detect two cancer-causing mutations that had previously defied genetic diagnosis. One of the families studied, Warthin Family G, was the first kindred with a hereditary colon cancer syndrome described in the biomedical literature.
Patent AU-692191-B2 (AU)
Title: Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
Inventor: HUMES DAVID H
IPC: A61K35/12
Filed: 1994-10-11
Granted: 1998-06-04
Abstract: A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Renal cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure as well as studying renal tubululogenesis in vitro.
Patent AU-562279-B2 (AU)
Title: Antigen drug
Inventor: KOKUBU TADAO
IPC: A61K38/02
Filed: 1982-03-04
Granted: 1987-06-04
Abstract: An antigen drug or a process of producing it available for the oral, percutaneous and the permucous membrane immunotherapies with autoimmunization equilibrium induced in feeling of cold, what is called "HIESHO" in Japanese, contracting nonspecific allergic diseases caused from auto-antigen-antibody reaction by a typical antibody. The antigen drug is available in the liquid type and the ointment type which are effective to the percutaneous and the permucous membrane immune therapies of non-specific allergic diseases. The antigen drug is made from urea of normal and healthy person.
Patent DE-1800434-B2 (DE)
Title: Yarn making machines installation - broken yarns indicator system electrically signals location of excess breaks
IPC: D01H13/32
Filed: 1968-10-01
Abstract: Spindles of multiple spinning or twisting machines in a textile mill have yarn break detectors which signal the presence on the machine side of broken yarns, the signals being fed to a discriminator which distinguishes the signalling of a predetermined number of broken yarns at a machine side location, and which is connected to a warning at signalling device at or near the machine side location so as to energise the device when the number of broken yarns exceeds the predetermined number, the latter being selected as that number which causes inefficient operating conditions to be in existence so that attention by an operator is needed.
Patent DE-2005249-B2 (DE)
Title: Points control and monitoring system for electrified railways - has series of intermediate repeaters to reduce induced interference
IPC: B61L7/08
Filed: 1970-02-05
Abstract: The railway track switch-points control and monitoring system reduces the risk of faulty operation due to induced, interference voltages by dividing the signalling conductor path lengths into a series of short stretches. Induced voltages then have the minimum effect. Each set of points (W1-5) and its associated drive mechanism (A1-3) is connected to a local switching unit (T2)(T3/2) via main and supervisory circuit (a3/3)(b3/3). The supervisory circuit monitors the correct operation of the points mechanism and returns a signal to the main control (WG1-3) in the central signal-box (S). Only the set of points (W1) in the immediate vicinity of the control centre is operated by direct link (a1-b1). Each group switching unit is fed with power via separate isolating transformers (TS1-3) connected to the high voltage supply feeder.