Patent SG-11201902988U-A (SG)
Title: Novel hpv16 non hla-restricted t-cell vaccines, compositions and methods of use thereof
Inventor: BEDU-ADDO FRANK
IPC: A61K39/00
Filed: 2017-10-04
Abstract: International Patent Classification: A61K 38/00 (2006.01) C07K 14/00 (2006.01) A61K 39/12 (2006.01) A61K 9/127 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: (22) International Filing Date: PCT/US2017/055119 1218k9 OStim # # I _r_71111M 11 s-7 ,• (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 April 2018 (12.04.2018) WIPO I PCT ill~~~~~~~~ 011101010VIIIOH olo omoiloo Em Eno iflo oimIE (10) International Publication Number WO 2018/067689 Al 04 October 2017 (04.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/404,458 05 October 2016 (05.10.2016) US (71) Applicant: PDS BIOTECHNOLOGY CORPO- RATION [US/US]; 675 US Highway 1, North Brunswick, NJ 08902 (US). (72) Inventors: BEDU-ADDO, Frank; 24 Tamar Lane, Stam- ford, CT 06905 (US). CONN, Greg; Orense 17, Esc. Dcha. 4 Dcha., 28020 Madrid (ES). WARD, Martin; 4513 Dothan Drive, Lexington, KY 40515 (US). WOOD- WARD, Jerold; 611 Ballard Street, Lexington, KY 40508 (US). (74) Agent: KULKARNI, Sima, Singadia; DLA Piper LLP (US), 1650 Market Street, Suite 4900, Philadelphia, PA 19103 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: NOVEL HPV16 NON HLA-RESTRICTED T-CELL VACCINES, COMPOSITIONS AND METHODS OF USE THERE- OF FIGURE 1 2 3 5 7 9 2 3 5 79 2 3 5 7 9 2 3 5 7'9 2 5 7 2 3 5 7 9 C Subject 2-1 2-2 2-3 5-1 5-2 5-1 00 N O (57) : Novel human papillomovirus immunogenic compositions and methods of use thereof are provided. The compositions comprise unique combinations of multi-epitope peptide sequences specifically selected and designed to be effectively processed and 0 cross-presented to T-cells. The peptides utilized in the compositions display high levels of binding with HLA-supertypes. The immuno- \" genic compositions are broadly applicable to large proportions of target populations. The compositions comprise adjuvants such as C cationic lipids. [Continued on next page] fT X Ci) 800.00 700.00 600.00 500.00 400.00 300.00 200.00 100.00 1-1 13.00 Visit WO 2018/067689 Al MIDE111111111101111111111111111111111111111111 11111 11111 H11111110 111110111111111111 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))