baber/WOPTO huggingface dataset:
Patent UY-33556-A (UY)
Title: "6-Cicloalquil-pirazolopirimidinonas para el tratamiento de trastornos del SNC"
Inventor: GERHARD SCHAENZLE
IPC: A61K31/351
Filed: 2011-08-12
Abstract: La invención se refiere a 6-cicloalquil-pirazolopirimidinonas según la fórmula (I).NNNNOHHDR1[ ]m(R2)n (I), en donde R1 es un grupo heteroarilo aromático de 5 o 6 eslabones,R2 es un sustituyente opcional, D ciclopentilo, ciclohexilo, tetrahidrofuranilo, tetrahidropiranilo o 2-, 3- o 4-piridilo . opcionalmente sustituidos, m = 1 o 2 y n es 0, 1 o 2.  Los nuevos compuestos son para el tratamiento de estados relacionados con déficit de percepción, concentración, aprendizaje o memoria. Tales estados pueden por ejemplo estar asociados con la enfermedad de Alzheimer, esquizofrenia y otras enfermedades.
Patent UY-34356-A (UY)
Inventor: BOTHE DR ULRICH
IPC: A61K31/58
Filed: 2012-09-28
Abstract: Escanear figura (I), página 6/95 SGDD
Patent UY-34784-A (UY)
Inventor: ALVARES ANTONIO CARLOS TEIXEIRA
IPC: B65D1/00
Filed: 2013-05-03
Abstract: Scan Fig 2
Patent UY-38251-A (UY)
Title: Moléculas de unión contra bcma y usos de las mismas
Inventor: ABUJOUB AIDA
IPC: C12P21/08
Filed: 2019-05-30
Abstract: Se proporciona moléculas de unión a BCMA que se unen específicamente a BCMA humano, conjugados que comprenden las moléculas de unión a BCMA y composiciones farmacéuticas que comprenden esas moléculas y los conjugados. Se proporciona además métodos de uso de las moléculas para tratar cánceres que expresan BCMA en la superficie celular. Adicionalmente se proporcionan células huésped recombinantes modificadas por ingeniería genética para expresar las moléculas de unión a BCMA y métodos de producción de las moléculas de unión a BCMA cultivando las células huésped en condiciones en la que las moléculas de unión a BCMA se expresan.
Patent UY-39128-A (UY)
Title: Composiciones y métodos para modular la senda de señalización de wnt
Inventor: ZHANG GUOBAO
IPC: C07D413/14
Filed: 2021-03-12
Abstract: La presente invención se refiere a composiciones y métodos para modular la senda de señalización de Wnt, que tienen la fórmula (1) o (2): en donde R1, R2, R3, A1, A2, X1, X2, X3, X4, Y, y Z son como se definen anteriormente.
Patent UY-39571-A (UY)
Title: Oxadiazoles fungicidas y sus mezclas
Inventor: MCMAHON TRAVIS CHANDLER
IPC: C07D413/14
Filed: 2021-12-16
Abstract: Se divulga una composición fungicida que comprende (a) al menos un compuesto seleccionado de los compuestos de Fórmula 1, incluyendo todos los geométricos y estereoisómeros, tautómeros, N-óxidos y sales de los mismos, y (b) al menos un compuesto fungicida adicional; método para controlar enfermedades de las plantas provocadas por fitopatógenos fúngicos y una composición que comprende: (a) al menos un compuesto seleccionado de los compuestos de Fórmula 1 descritos anteriormente, N-óxidos y sales de los mismos; y al menos un compuesto o agente de control de plagas de invertebrados.
Patent YU-26283-A (YU)
Title: Process for the manufacture of a liquid detergent mixture
Inventor: AKRED B J
IPC: C09K23/00
Filed: 1983-02-07
Abstract: Pourable, fluid, non sedimenting, laundry detergent composition, comprising water, surfactant, builder, a surfactant desolubilizing electrolyte and, optionally, the usual minor ingredients, consist essentially of : at least one predominantly aqueous liquid phase which is separable into a distinct layer by centrifuging the composition at 800 times normal earth gravity at 25 DEG  C. for 17 hours, and which contains at least part of the electrolyte and less than 75% by weight, preferably less than 10% by weight, of the surfactant, and one or more other phases which together contain at least part of the builder as solid particles dispersed in the composition and at least part of the surfactant, preferably either as a network of solid surfactant hydrate, or as a "G" phase liquid crystal which may be associated with an "L" phase, micellar solution.
Patent YU-30297-A (YU)
Inventor: ANDREA CESURA
IPC: C07D417/12
Filed: 1997-07-11
Abstract: Ovaj pronalazak se odnosi na primenu derivata sulfonamida opšte formule u kojoj R označava niži-alkil, fenil, benzil, naftil, piridil ili tienil, koji su opciono supstituisani sa jednim ili više niži-alkil-, niži-alkoksi-, niži-alkilkarbonilamino-, halogen-, cikloalkil-, nitro-, amino-, metilendioksi-, fenoksi- ili benziloksi-supstituenata, i aromatični prstenovi, sa svoje strane, mogu biti supstituisani nitrogrupom, halogenom ili amino-grupom, R1-R4 označava vodonik, halgoen, hidroksi, niži-alkil, nitro, cijan, amino, niži-alkoksi, benziloksi, trifluorometil ili fenil, koji je opciono supstituisan sa jednim ili više niži-alkil-, trifluormetil-, nitro-, amino-ili hidroksi-supstituenata, i u kojoj R1 i R2 ili R2 i R3 zajedno mogu formirati benzenski prsten koji opciono može biti supstituisan halogenom, trifluormetil-, nitro-, niži-alkil- ili niži-alkoksi-grupom, i njihova farmaceutski prihvatljivih soli kao inhibitora kinurenin-3-hidroksilaze u suzbijanju ili sprečavanju neurodegenerativnih poremećaja, neuroloških poremećaja koji rezultiraju iz aktivacije imunog sistema ili psihijatrijskih oboljenja i, odnosno, za proizvodnju odgovarajućih lekova.
Patent YU-53095-A (YU)
Title: Čeoni sastav pomoću umetka
Inventor: BRANISLAV IVANOVIC
Filed: 1995-08-04
Abstract: Pločasti ili izduženi elementi (1, 2, 3 i 4) svojim čeonim površinama (14, 15, 16 i 17) naležu na površine (18, 19, 20 i 21) umetka (5) i istovremeno zakošenim površinama (6 do 13) svaki od elemenata (1, 2, 3 i 4) naleže na zakošene površine (6 do 13) dva susedna elementa (1, 2, 3 i 4). Umetak (5) može biti pravilna ili nepravilna prizma, cilindrično ili telo konstantnog ovalnog ili nepravilnog, punog ili složenog preseka, telo slično cevi ili telo koje sadrži mehanizam, čija je visina manja, jednaka ili veća od visine pločastih ili izduženih elemenata (1, 2, 3 i 4), s tim da su poprečni preseci čeonih površina (14, 15, 16 i 17) rubova elemenata (1, 2, 3 i 4) podudarni sa poprečnim presecima segmenata (18, 19, 20 i 21) površine umetka (5) na koje naležu i da je zbir uglova (22, 23, 25, 26, 28, 29, 31 i 32), koji zakošene površine (6 do 13) dva susedna elementa-(1, 2, 3 i 4) zaklapaju sa osovinskim ravnima (34 do 37) elementa (1, 2, 3 i 4) kojima pripadaju, jednak uglu (24, 27, 30 i 33) koji zaklapaju osovinske ravni (34 do 37) ta dva susedna elementa (1, 2, 3 i 4). Stabilna konstrukcija se ostvaruje spajanjem čeone površine (14, 15, 16 i 17) svakog od elemenata (1, 2, 3 i 4) sa odgovarajućom površinom (18, 19, 20 i 21) umetka (5) na jedan od poznatih načina, na primer: lepljenjem, stezanjem ili slično.
Patent YU-4400-A (YU)
Inventor: MIROSAVIC BORIVOJE
Filed: 2000-01-28
Abstract: Čaj za lečenje urinarnog trakta je čaj koji se satsoji od smeše lekovitih biljaka iz porodice Epilobium, koji pomaže u lečenju urinarnog trakta, prevashodno bolesti prostate, bešike i bubrega.
Patent AT-A166489-A (AT)
Inventor: HASLER KURT DIPL ING
IPC: A45C13/16
Filed: 1989-07-10
Abstract: The cover for box-like containers is guided displaceably at the edges in guide grooves which have a curved course in some sections. The cover consists of a multiplicity of laminar strips (11) which rest directly on one another with their longitudinal sides and are produced from transparent, preferably clear, plastic. These strips (11) of equal length are connected to one another at their two outer edges by means of plastic wires (13). For this purpose, the strips (11) have pins (12) on their narrow sides, which pins lie essentially coaxially with the longitudinal mid-axis of the respective strip (11). The plastic wires (13) run through said pins (12). <IMAGE>
Patent BE-821680-A (BE)
Title: Equipment for mixing granular materials - partic. suitable for foundry mould mixts. contg. sand, resin and catalyst
IPC: B22C5/02
Filed: 1974-10-30
Abstract: A mixer for two or pref. three different matls. has a hollow rotating shaft carrying discs, spaced one above the other, on to which the components of the mixt. are fed separately by pipes passing through the hollow shaft. The components are thrown off the discs by centrifugal force on to the wall of a rotating cone shaped drum where they are thoroughly mixed by friction and shearing, thrown in to the body of the mixer and discharged by an outlet at the bottom. The wall of the drum may have a removable plastic lining. The mixer is partic. suitable for mixing sand, resin and catalyst to form a rapidly setting mixt. for foundry moulds. The matls. are kept separate from one another until the mixt. is required when they are thoroughly mixed and charged to the mould immediately.
Patent BE-898770-A (BE)
Title: Ensemble de lampe
IPC: H01K7/00
Filed: 1984-01-27
Abstract: Ensemble de lampe comprenant une enveloppe, avec une ouverture, contenant une ampoule, une lentille de Fresnel, une lentille condenseuse et une lentille extérieure installée dans l'enveloppe, très près de l'ouverture, permettant aux faisceaux émanant de la lentille condenseuse de passer à travers plusieurs parties perméables à la lumière, correspondant à la lentille condenseuse, respectivement, dont les surfaces ont des angles d'inclinaison différents, par lesquelles les faisceaux réfractés sont émis de façon telle que leurs directions de réfraction aient, en tournant, une variation graduelle d'inclinaison.
Patent BE-901857-A (BE)
Title: Pad for cleaning users back - comprises length of washing flannel containing soap pulled to and fro across shoulders
IPC: A47K7/02
Filed: 1985-03-01
Abstract: The back-washing pad comprises a length of washing flannel to suit the size of the user and containing a cake of soap. - The pad is pulled to and fro across the back and shoulders. The pad can be made in different sizes for children and adults, the length and width being varied.
Patent BE-904047-A (BE)
Title: Derives a cycle imidique de 2-(4-butylpiperazine-1-yl) pyridines et leur application antipsychotique.
IPC: C07D213/64
Filed: 1986-01-15
Abstract: Des pipérazines N,N disubstituées de formule I dans lesquelles un substituant est un cycle pyridine-2-yl substitué et le deuxième substituant est une chaine de butylène liée au cycle imidique d'hétérocycles, tels par exemple azaspiro (4,5) décanedione, dialkylglutarimide, thiazolidinedione, spirocyclopentylthiazolidinedione, ou morpholine-2,6-dione. Ces composés présentent des propriétés psychotropes et le 2-(4-(4-(2,4-dioxo-1-thia-3-azaspiro (4,5)nonane-3-yl)butyl)-1-pipérazinyl)-pyridine-3-carboxaldéhyde est un exemple typique d'un composé présentant une activité antisychotique sélective.
Patent BE-904835-A (BE)
Title: Nouveaux derives d'isoquinoleine, leur procede de preparation, leur application en therapeutique et produits intermediaires.
IPC: C07D491/14
Filed: 1986-05-28
Abstract: Composés de la formule générale I dans laquelle R1, R2, R3 et R4 peuvent etre autres représenter chacun un atome d'hydrogène, et R5 et R6 représentent chacun un atome d'hydrogène ou un groupe -OCOCH2NR7R8 (où R7 et R8 peuvent etre autres représenter chacun un atome d'hydrogène, pourvu que si l'un de R7 et R8 est un atome d'hydrogène, l'autre soit un groupe -OCOCH2NR7R8. Ces composés et leurs sels physiologiquement acceptables sont utiles en thérapie anticancéreuse.
Patent BE-762260-A (BE)
Title: Anti-caries compn contng hexafluoro antimonates
IPC: A61K8/21
Filed: 1971-01-29
Abstract: Anti-caries compn. contng. hexafluoro antimonates. Title compn. comprises 0.01-30.0% HSbF6, NaSbF6, or KSbF6 and 0.001-10.0% In (OH)3, InCl3 or InBr3, the cation of antimino fluoride to indium compd. being 1:1 to 10:1 and an aq. soln. of the compn. having a pH of 2.5-3.5. Compns. may be in the form of collutoria, dentifrices, chewing gums, pastes or solns. for local application. Demineralisation of the teeth is reduced.
Patent CA-1042899-A (CA)
Inventor: SAHM WILFRIED
IPC: D06L3/12
Filed: 1973-12-17
Granted: 1978-11-21
Abstract: PROCESS FOR THE PREPARATION OF FURAN COMPOUNDS Abstract of the Disclosure Novel azomethines are obtained when reacting a tertiary amine with an aromatic aldehyde or ketone having in ortho-position an activated methoxy group. These azomethines are capable of ring closure to yield a benzofurane and said tertiary amine. The benzofuranes are optical brighteners tranquilizers or intermediates for optical brighteners, fluorescent dyestuffs, scintiallators, sensibilizers for electrophotographic coatings.
Patent CA-1038627-A (CA)
Inventor: MCMAHON JOSEPH F
IPC: C01B3/22
Filed: 1974-07-16
Granted: 1978-09-19
Abstract: GASIFICATION PROCESS                ABSTRACT OF THE DISCLOSURE         A process for the gasification of carbonaceous mat-erials to produce a high B.T.U. gaseous product is disclosed.          The process includes the partial oxidation of a fluid hydro-carbon to produce a gaseous mixture of carbon monoxide and hydrogen, followed by contacting the gaseous mixture with a relatively cool, finely-divided carbonaceous solid material.          The resulting gas-solid mixture is then passed along with a carbonaceous feed into a high velocity transfer line reactor furnace, and the solid material is removed from the gas solid mixture which emerges from the reactor furnace.  The present invention is particularly well-suited for the hydrogasifica-tion of high boiling, carbon-rich feedstocks such as reduced crude oils.
Patent CA-1058756-A (CA)
Inventor: KILBY JACK S
IPC: B41J13/00
Filed: 1974-08-08
Granted: 1979-07-17
Abstract: ELECTRONIC CHECK WRITER            Abstract of the Disclosure A personal check accounting unit includes an alphanumeric keyboard for entry of transaction data including an alphabetic portion and a numeric portion.          The transaction data is stored and a calculator unit responds to the numeric portions to operate thereon to compute balance data.  A memory receives and stores the output from the calculator, and print means is actuated in response to entry of the alphanumeric data for printing a verification thereof along with the contents of the memory.          In one aspect, a check pack holder is attached to the printer, and an electrical storage unit in the pack powers the print means to print the quantity of checks in the pack.
Patent CA-1042897-A (CA)
Inventor: PATTON TAD L
IPC: C07D207/44
Filed: 1974-10-07
Granted: 1978-11-21
Abstract: ABSTRACT An improved process for preparing those imides which result from the reaction of an anhydride with one or more isocyanate groups which comprises effecting reaction in the presence of cyanide ion as a catalyst.
Patent CA-1057439-A (CA)
Inventor: CAMELON MELVILLE J
IPC: C09D133/06
Filed: 1974-11-12
Granted: 1979-06-26
Abstract: ABSTRACT           Improved powder paint compositions providing greater depth variation of metal pigment particles comprise (1) aluminum flakes individually encapsulated in a thin, continuous, thermoplastic, organic film-former containing an ammonium salt selected from tetraalkyl ammonium halides and substituted tetraalkylammonium halides wherein at least one alkyl radical is replaced with an aryl, phenoxy, or alkoxy radical and (2) a particulate, organic film-former. The encapsulated aluminum flakes are prepared by intimately dispersing the aluminum flakes in a solution of the thermo-plastic, organic filmformer and the ammonium salt in a volatile solvent and spray drying the resultant dispersion. In the preferred embodiment, the particulate, organic film-former is also s thermoplastic material and, in the most preferred embodiment, it is of the same composition as the coating on the aluminum flakes.
Patent CA-1051433-A (CA)
Inventor: NISHIMURA HARUKI
IPC: C07D295/096
Filed: 1975-01-21
Granted: 1979-03-27
Abstract: 1-SUBSTITUTED-4-(1,2-DIPHENYLETHYL)-PIPERAZINE DERIVATIVES AND THEIR SALTS AND THE PREPARATION THEREOF          Abstract of the Disclosure: 1-Substituted-4-(1,2-diphenylethyl)piperazine deriv-atives of the formula:                              [I]   wherein X is hydroxy, methoxy, methyl or trifluoromethyl; and R is an unsubstituted monocycloalkyl group having 6 to 8 carbon atoms or 2-methoxyphenyl; provided that when X is hydroxy, R is cyclohexyl, and when X is trifluoromethyl, R is 2-methoxyphenyl, and their pharmaceutically acceptable salts, which have ex-cellent analgesic, anti-tussive and anti-inflammatory activi-ties, without undesirable side effect such as narcotic activ-ity, and a process for the preparation thereof.
Patent CA-1062276-A (CA)
Title: N,n-dialkylamino diphenylamines utilisables pour la teinture des fibres keratiniques, en particulier des cheveux humains_______________________
Inventor: KALOPISSIS GREGOIRE
IPC: C07C275/40
Filed: 1975-02-21
Granted: 1979-09-11
Abstract: La présente invention concerne de nouvelles diphénylamines qui répondent à la formule générale: (I) dans laquelle: R1 et R4 désignent un atome d'hydrogène, d'halogène, un groupement alkyle inférieur, alcoxy inférieur, amino, alkyle inférieur amino, acylamino, carbamylalkyl inférieur amino, hydroxyalkyl inférieur amino, carbalcoxy inférieur amino, uréido; R2 et R3 désignent un atome d'hydrogène, d'halogène, un groupement alkyle inférieur, alcoxy inférieur, acylamino ou uréido; R5 et R8 désignent un atome d'hydrogène ou d'halogène, un groupement alkyle inférieur ou alcoxy inférieur; R6 et R7 désignent un groupement alkyle inférieur, avec la condition que lorsque R6 et R7 désignent tous deux méthyle, R1 ou R4 représentent obligatoirement un groupement amino, alkylamino, carbamylalkylamino, hydroxyalkylamino ou uréido, ou bien R1 ou R4 représentent acylamino et R2 et R3 ne représentent pas tous deux hydrogène et lorsque R6 et R7 désignent tous deux éthyle, R2 et R3 ne représentent pas tertiobutyle.  On entend par groupement alkyle inférieur ou alcoxy inférieur, un groupement contenant de 1 à 6 et de préférence de 1 à 4 atomes de carbone.  Les diphénylamines de formule (I) sont préparées par réduction des leucodérivés des indoanilines de formule générale (II): (II) dans laquelle R1 à R8 ont les significations ci-dessus indiquées. Composition tinctoriale pour fibre kératinique renfermant des composés de formule (I).  Les teintures ainsi obtenues présentent des qualités de solidité et d'intensité de coloration supérieures à celles des teintures réalisées par application directe des indoanilines, en raison de la meilleure solubilité des leucodérivés de ces composés et une meilleure pénétration de la fibre kératinique.  Procédé de teinture des fibres kératiniques et de coloration des cheveux humains utilisant ces compositions.
Patent CA-1037028-A (CA)
Inventor: JOLLES PIERRE
IPC: C12P13/08
Filed: 1975-05-05
Granted: 1978-08-22
Abstract: ABSTRACT OF DISCLOSURE           Watersoluble extracts of corynebacteria cells are obtained by a process which comprises the steps of subjecting bacterial residues of corynebacteria  containing diaminopimelic acid, e.g. Corynebacterium parvum cells, to a mild extraction and of isolating the watersoluble extracts so obtained by physico-chemical methods.  Said extracts are useful as immunological adjuvants.
Patent CA-1040198-A (CA)
Inventor: SAKAI KIYOSHI
IPC: C07C405/00
Filed: 1975-05-22
Granted: 1978-10-10
Abstract: ABSTRACT OF THE DISCLOSURE          Prostenoic acid derivatives, having anti-ulcer activity of formula                 (I) wherein:-A represents a hexamethylene group; R1 represents an n-propyl group; R2 and R3 may be the same or different and each represents an alkyl group having from 1 to 4 carbon atoms; and R4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms; and pharmaceutically acceptable salts thereof are prepared by reducing a compound of formula                 (II) (wherein A, R1, R2, R3 and R4 have the meaning previously given; and * suitably by means of a metal hydride complex reducing agent, removing the carbonyl-protecting group from the reduction product, and optionally salifying the resulting compound of formula (I) to obtain a pharmaceutically acceptable salt.          *Z represents a carbonyl-protecting group)
Patent CA-1052118-A (CA)
Inventor: CONNOR STEPHEN R
IPC: A01N47/22
Filed: 1975-09-02
Granted: 1979-04-10
Abstract: SYNERGISTIC HERBICIDAL      COMPOSITIONS             Abstract of the Disclosure This invention relates to herbicidal compositions comprised of a diphenyl ether herbicide and a paraquat or diquat salt, the weight of the diphenyl  ether herbicide to the paraquat or diquat salt ranging from about 1:10 to about 10:1.  These compositions exhibit synergistic activity in the control of weeds, and particularly in the control of weeds of the Compositae family, such as the Lactuca and Cirsium species.  Preferably the diphenyl ether herbicide is one which has the formula        I   wherein X is a hydrogen atom, a halogen atom, a trihalomethyl group, an alkyl group, or a cyano group, Y is a hydrogen atom, a halogen atom, or a trihalomethyl group, and Z is a hydrogen atom, a hydroxy group, an alkoxy group, an alkyl group? a halogen atom, an amino group, an alkylthio group, a cyano group, a carboxy group, a carbalkoxy group, a carboxyalkyl group, a carbalkoxy-alkyl group, an alkanoyloxy group, an alkanoyloxy group, or a carbamoyloxy group.
Patent CA-1052656-A (CA)
Inventor: BARRADAS GEORGE
IPC: A45D1/04
Filed: 1975-11-18
Granted: 1979-04-17
Abstract: ABSTRACT OF THE DISCLOSURE           A steam curling iron is provided with a set of inter-changeable tubular curling mandrels, each of which is adapted to be slid onto the curling arm of the iron.  The curling arm has an operative section constituted by a tubular barrel with a row of perforations in a lower region of the barrel to permit the escape of steam therefrom.  The perforations are normally closed by a valve plate which is spring-biased to the closed position and which is displaced to the open position when a mandrel is slid onto the curling arm.
Patent CA-1066186-A (CA)
Inventor: ATASOY KAYA
IPC: A61K33/18
Filed: 1975-11-28
Granted: 1979-11-13
Abstract: Abstract of the Disclosure Preparation of iodophor granules of practically uniform composition and particle size consisting of poly-N-vinyl-pyrrolidone, iodine and substance releasing iodide ions by combining with uniform thorough mixing a)   a solution and/or colloidal suspension of elementary iodine and a substance releasing iodide ions in a first solvent or solvent mixture, as well as b)   a solution and/or colloidal solution and/or suspension of PVP in a second solvent or solvent mixture which has a surface tension different from that of the first solvent or solvent mixture, and in which PVP is at least partially soluble or wettable, and in which the substances dissolved or suspended in the first solvent or solvent mixture are insoluble or only slightly soluble, and separating and drying the granules formed.
Patent CA-1054570-A (CA)
Inventor: YAREMCHUK GEORGE
IPC: A47B65/00
Filed: 1976-01-08
Granted: 1979-05-15
Abstract: ABSTRACT OF THE DISCLOSURE           An elongated strip of magnetic material in combina-tion with bookends, having magnetic members secured to the bottoms thereof whereby the magnetic bookends may be more efficiently utilized on wooden desks or the like in conjunction with the metallic strip.
Patent CA-1061735-A (CA)
Inventor: KUBACKI EDWARD F
IPC: B23Q7/04
Filed: 1976-03-09
Granted: 1979-09-04
Abstract: ABSTRACT OF THE DISCLOSURE         Work pieces, particularly open top, closed bottom thin-walled shells of can dimension, are transferred from a magazine at a supply station to another station by a reciprocal shuttle having a pocket for receiving the shells in ready position at the supply station; at the other station, a reciprocal loader transfers the shell laterally from the shuttle to a work station where the work product is produced,  e.g. the shells are located on a mandrel and the free edge trimmed by a cutting knife mounted on a rotary cylindrically operable disc which cooperates with an opposed cutting edge which is part of the mandrel.  The shuttle incorporates a second pocket to receive the work product and includes a surface for gating the supply magazine as an incident to shuttle travel.  By locating the path of the shuttle above the path of the loader, it is possible to coordinate shuttle and loader movement for maximum utilization of time.  Shells fed to the magazine are constantly aligned inside the magazine to assure effective bottom feed from the magazine to the shuttle.