baber/WOPTO huggingface dataset:
Patent EA-001891-B1 (EA)
Title: Delayed coking process
Inventor: NIELSEN DAVID K
IPC: C10B39/04
Filed: 1998-06-11
Abstract: 1. A delayed coking process in which a pair of coke drums each supported by a skirt section welded to said drum are alternately filled and emptied, and in which the emptying portion of the cycle comprises the steps of: (a) steaming out the filled coke drum to remove residual volatile matter from the drum; (b) quenching the hot coke bed with water; c) draining quench water from the coke drum; (d) opening the top of the coke drum and drilling a pilot hole through the coke bed therein; (e) drilling out the coke from the coke bed between the pilot hole and the coke drum wall by radially directed drill water and removing the coke through an opening in the bottom of the coke drum; (f) closing the top and bottom openings of the coke drum; and (g) prior to introducing feed into the emptied drum, preheating the empty drum by passing hot coke drum vapors through the drum; the improvement wherein the metal stresses at the junction of the coke drum and skirt are reduced by applying cooling fluid to the exterior portion of said coke drum adjacent the junction of the drum shell and the skirt of said drum during the introduction of quench water into said drum, thereby preventing excessive thermal stresses. 2. The process of claim 1 wherein said cooling fluid is applied to the exterior of said drum during the introduction of quench water by utilizing a cooling jacket surrounding said drum near the junction of the shell and the supporting skirt thereof. 3. The process of claim 2 wherein said cooling fluid is a gas. 4. The process of claim 3 wherein said cooling fluid is air. 5. The process of claim 3 wherein said cooling fluid is low pressure steam. 6. The process of claim 2 wherein said cooling fluid is a liquid. 7. The process of claim 6 wherein said cooling fluid is water. 8. A method for reducing metal stresses in a coke drum which occur during the quenching step comprising applying a cooling fluid to the external part of the coke drum adjacent to the area where the coke drum and the coke drum supporting skirt are connected, reducing the temperature differential between the drum interior and the supporting skirt connection thereby reducing metal stressed during the quenching step.
Patent EA-006488-B1 (EA)
Title: Peptide, composition for oral administration, kit (variants), method of ameliorating intensity a symptom of atherosclerosis (variants) and method of mitigating or preventing a coronary complications in a mammal (variants)
Inventor: FOGELMAN ALAN M
IPC: C07K14/00
Filed: 2001-08-23
Abstract: This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides comprises at least one class A amphipathic helix and at least one D-amino acid. The peptides are highly stable and readily administered via an oral route.
Patent EA-007254-B1 (EA)
Title: Compounds specific to adenosine a, aand areceptor and uses thereof
Inventor: CASTELHANO ARLINDO L
IPC: A61P11/06
Filed: 2001-11-30
Abstract: This invention pertains to compounds which specifically inhibit the adenosine A, A, and Areceptors and the use of these compounds to treat a disease associated with A, A, and Aadenosine receptors in a subjects, comprising administering to the subject a therapeutically effective amount of the compounds.
Patent EA-005471-B1 (EA)
Title: Method for combusting natural gas in approach flow
IPC: F23D14/20
Filed: 2002-01-30
Abstract: The invention can be used for industry, public service and other branches of national economy, which use natural gas as the energy vector. The natural gas delivery is carried out through gas-dividing orifices. The ratio between the orifices spacing and the diameter thereof is equal to 2-5. The use of the inventive method for combusting natural gas in an approach flow makes it possible to obtain an effective carburation, ensure an effective cooling of elements of a gas-fired burner with the aid of fuel. The invention also makes it possible to develop an ecological gas-fired burner.
Patent EA-007502-B1 (EA)
Title: Nicotin-or isonicotin benzothiazole derivatives
Inventor: FLOHR ALEXANDER
IPC: A61P9/04
Filed: 2002-11-11
Abstract: The present invention relates to compounds of the general formula(I) wherein Ris phenyl, piperidin-1-yl or morpholinyl; A is-O-and R is-(CH)-N(R")-C(O)-lower alkyl, - CH)-O-lower alkyl, - CH)-O- CH)-O-lower alkyl, lower alkyl, - CH)-morpholinyl, - CH)-phenyl,- CH)-N(R"), CH)-pyridinyl, - CH)-CF, CH)-2-oxo-pyrrolidinyl or C-cycloalkyl; R" is independently from each other hydrogen or lower alkyl and n is 1 or 2; or A is-N(R')-and R is lower alkyl, C-cycloalkyl, - CH)-O-lower alkyl, - CH)-pyridinyl, - CH)-piperidinyl, - CH)phenyl, CH)-N(R")-C(O)-lower alkyl, -(CH2)n-morpholinyl, or CH)-N(R"); R' and R" are independently from each other hydrogen or lower alkyl and n is 1 or 2; or A is CH- and R is-N(R")- CH)-O-lower alkyl, -N(R")S-lower alkyl, or is acetidinyl, pyrrolidinyl or piperidinyl, which optionally substituted by hydroxy or lower alkoxy or is morpholinyl, -N(R")- CH)-C-cycloalkyl, -N(R")- CH)-C(O)O-lower alkyl, -N(R")- CH)-C(O)OH, -2-oxo pyrrolidinyl, -N(R")-C(O)O-lower alkyl, -O CH)-O-lower alkyl or alkoxy; R" is independently from each other hydrogen or lower alkyl and m is 1, 2 or 3; A is S- and R is lower alkyl; or A-R are together piperazinyl, substituted by lower alkyl, -C(O)-lower alkyl or a oxo group, or is piperidinyl, substituted by lower alkoxy or hydroxy, or is morpholinyl, substituted by lower alkyl, or is C-cycloalkyl, -azetidin-1-yl, optionally substituted by hydroxy or lower alkoxy, thiomorpholine-1,1-dioxo, -tetrahydopyran or 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl; and to pharmaceutically acceptable acid addition salts thereof. It has been found that the compounds of general formula I are adenosine receptor ligands. Specifically, the compounds of the present invention have a good affinity to the A-receptor and they are therefore useful in the treatment of diseases related to this receptor.
Patent EA-008740-B1 (EA)
Title: Process for the selective oxidation of hydrogen sulphide
Inventor: GEUS JOHN WILHELM
IPC: C01B17/04
Filed: 2004-09-28
Abstract: A process for the selective oxidation of hydrogen sulphide in a hydrogen sulphide containing feed gas to elemental sulphur, wherein the hydrogen sulphide containing feed gas (3), an inert liquid medium (5), and a molecular-oxygen containing gas (4) are supplied to a reaction zone (1) comprising at least one catalytic zone (2) comprising an oxidation catalyst to form elemental sulphur and a gaseous stream depleted in hydrogen sulphide (8), in which process the oxidation catalyst of each catalytic zone (2) is contacted with hydrogen sulphide and/or molecular-oxygen in the presence of inert liquid medium at a temperature in the range of from 120 to 160°C, under such conditions that the elemental sulphur formed is essentially in liquid form and is removed from the reaction zone with the inert liquid medium.
Patent EA-012280-B1 (EA)
Title: Novel tetrahydropyridothiophenes derivatives
Inventor: PEKARI KLAUS
IPC: A61K31/4365
Filed: 2005-05-25
Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
Patent EA-012607-B1 (EA)
Title: NOVEL HETEROCYCLIC NF-kB INHIBITORS
Inventor: LEBAN JOHANN
IPC: C07D401/14
Filed: 2005-07-29
Abstract: The present invention relates to a compound of the general formula (III) and salts and physiologically functional derivatives thereof, or a stereoisomer thereof,wherein R-R, A, Z, r and X are as defined in the invention claims.
Patent EA-017831-B1 (EA)
Title: Food composition for binding acetaldehyde and method for the preparation thereof
Inventor: SUOVANIEMI OSMO
IPC: A23L33/00
Filed: 2006-04-03
Abstract: The invention relates to food compositions, comprising one or more acetaldehyde-binding compounds, wherein said acetaldehyde-binding compound is comprised in a food composition in an amount of at least 0.2 mkM compound/1 mkM acetaldehyde, wherein the acetaldehyde-binding compound is selected from a derivative or salt of cysteine. The purpose of the compositions is to reduce the amount of detrimental acetaldehyde in the area of the mouth, the pharynx, the oesophagus, the stomach, and the small and large intestines, and through this, to reduce the risk of developing cancers in these areas. The invention also provides a method for preparing a food composition characterised in that at least one acetaldehyde-binding compound selected from a derivative or salt of cysteine is added to a selected food product or a beverage in an amount of at least 0.2 mkM compound/1 mkM acetaldehyde.
Patent EA-010962-B1 (EA)
Title: Power unit of nuclear power plant and method of operation thereof
Inventor: TREVGODA MARK MIKHAILOVICH
IPC: G21D5/08
Filed: 2007-11-28
Abstract: A power unit of a nuclear power plant a method for operating thereof is proposed. The claimed power unit is characterized in that a gas-turbine power converter is used with a closed loop and a complex thermodynamic cycle , comprising, at least, two series-connected turbo-blower stations providing relatively high efficiency (36%). A fast neutron spectrum is ensured permitting to provide greater energy release in unit of a core zone volume, and, consequently, with lesser core zone volume greater power unit capacity can be achieved. A sodium coolant is used in the primary coolant circuit, which, thanks to the complex its thermal-physic properties provides the highest heat take-ff among the most distributed coolants in use in reactors with the fast neutron spectrum, moreover, the sodium coolant is less aggressive to materials of the primary coolant circuit compared to said liquid-metal coolants permitting to use more thermal-resistant materials in fuel element claddings and at the base thereof to achieve higher sodium temperature (500°C) at the reactor outlet. The higher coolant temperatures at the reactor outlet provides higher efficiency of the gas-turbine power converter.
Patent EA-014757-B1 (EA)
Title: Chimeric adenoviral vector, immunogen composition based thereon, a method for eliciting an immune response using the vector and isolated nucleic acid
Inventor: TUCKER SEAN N
IPC: C12N15/63
Filed: 2007-02-28
Abstract: The present invention provides chimeric adenoviral vectors and methods for using the vectors to elicit an immune response to an antigen of interest.
Patent EA-014547-B1 (EA)
Title: Fire-resistant glazing
Inventor: GOELFF PIERRE
IPC: C03C27/12
Filed: 2007-03-19
Abstract: The present invention relates to fire-resistant glazing. According to the invention, the transparent fire-resistant glazing comprises at least one intumescent layer of a hydrated alkali metal silicate between two glass sheets, the composition resulting in this layer, obtained without drying, comprising the use of an aqueous suspension of colloidal silica in an amount such that the silica introduced with this suspension is not less than 25% of the total silica in the intumescent layer and the silica/alkali metal oxide molar ratio is less than 4.
Patent EA-018257-B1 (EA)
Title: Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for treating female genital disorders
Inventor: DE LUIGI BRUSCHI STEFANO
IPC: A61K9/00
Filed: 2007-06-21
Abstract: A hydrophilic matrix is disclosed which comprises: a) at least one polyacrylic acid derivative in preferred amounts of 0.5-40%, b) at least one cellulose ether in preferred amounts of 30-90% and c) at least one disintegrant in preferred amounts of 2-50%, with respect to the weight of the matrix. This matrix is used in combination with at least one pharmaceutically acceptable active principle for manufacturing solid bioadhesive controlled release formulations for the treatment of vaginal disorders, such as vulvovaginal candidiasis, bacterial vaginosis or trichomoniasis. The matrix is used in solid formulations in amounts of about 5-60%, preferably 20-40%, and the active principle in amounts of about 2-70%, preferably 5-50% with respect to the weight of the formulation.
Patent EA-022588-B1 (EA)
Title: Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
Inventor: ANDERSON ERIC
IPC: C07J63/00
Filed: 2009-04-20
Abstract: The present invention relates to oleanolic acid derivatives, in particular to a compound of formula (I) and variables thereof, which have strong antioxidant and anti-inflammatory effect. Furthermore, the present invention relates to pharmaceutical compositions based on the provided compounds and to the use of the compounds for treating diseases.
Patent EA-016475-B1 (EA)
Title: Azol compounds for use as fxr modulators
Inventor: GENIN MICHAEL JAMES
IPC: A61K31/42
Filed: 2008-07-11
Abstract: Compounds of formula (I): formula (I)wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and diseases related to dyslipidemia.
Patent EA-021909-B1 (EA)
Title: Pharmaceutical composition for treatment of joint diseases
Inventor: DOROVSKIJ ALEXANDER VIKTOROVICH
IPC: A61P19/02
Filed: 2011-09-05
Abstract: The invention relates to the field of medicine and chemical-pharmaceutical industry, in particular to a pharmaceutical composition for treatment of joint diseases. The developed pharmaceutical composition contains glucosamine hydrochloride, the substance from the group of non-steroid anti-inflammatory drugs, transdermal product, ointment base characterised by the fact that it additionally contains allantoin, with the following ingredient ratio, wt.%: glucosamine hydrochloride - 0.5-10.0; allantoin - 0.05-20.0; non-steroid anti-inflammatory drug - 0.1-10.0; transdermal product - 0.5-20.0; ointment - the remainder. The claimed pharmaceutical composition has the wide spectrum and high level of specific pharmacological activity and demonstrates prolonged therapeutic effect, which is achieved due to ensuring the appropriate quantitative and quantitative formulation of the composition.
Patent EA-024120-B1 (EA)
Title: Invert emulsion drilling fluids and methods of drilling boreholes
Inventor: WAGLE VIKRANT BHAVANISHANKAR
IPC: C09K8/36
Filed: 2011-03-25
Abstract: An invert emulsion drilling fluid, and a method for the use thereof in drilling wellbores, with good rheological properties at high temperatures and pressures. In one embodiment, the drilling fluids are free of organophilic clays and lignites, free of calcium chloride, and comprise an alcohol in the internal phase, a quaternary ammonium emulsifier, and argillaceous solids. In one embodiment, the alcohol is a glycerol, a polyglycerol, or a mixture thereof. In one embodiment, the base oil for the emulsion is a paraffin and/or mineral oil. The drilling fluids provide good lubricity and high rates of penetration.
Patent EA-024159-B1 (EA)
Title: Glass substrate with interference colouration for a facing panel
Inventor: MOENS VINCENT
IPC: C03C17/36
Filed: 2011-07-29
Abstract: The invention relates to a glass substrate with interference colouration for a facing panel, comprising a glass sheet covered on one of the faces thereof by a stack of coatings including successively at least: a first transparent coating made from a dielectric material having an optical thickness at least greater than or equal to 5 nm and at most less than or equal to 258 nm; a semi-transparent functional coating having a geometric thickness at least greater than or equal to 0.1 nm and at most less than or equal to 50 nm; a second transparent coating made from a dielectric material and having an optical thickness at least greater than or equal to 20 nm and at most less than or equal to 300 nm; and a coating providing opacity or quasi-opacity and having a geometric thickness at least greater than or equal to 30 nm.
Patent EA-039246-B1 (EA)
Title: Method of treating cognitive impairments associated with hunter syndrome
Inventor: BARBIER ANN
IPC: A61K38/46
Filed: 2012-12-21
Abstract: The invention provides a method of treating cognitive impairments associated with Hunter syndrome, comprising administering intrathecally to a subject with Hunter syndrome a recombinant iduronate-2-sulfatase (I2S) enzyme at a therapeutically effective dose of 10 to 30 mg and an administration interval once a month for a treatment period of more than 6 months, and administrating intravenously the recombinant I2S enzyme at a therapeutically effective dose of 0.1 to 1 mg/kg body weight.
Patent EA-027370-B1 (EA)
Title: Dosing regimen of sedative
Inventor: KONDO MAKI
IPC: A61P25/20
Filed: 2013-08-30
Abstract: By intravenously administering a sedative comprising methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate or a salt thereof to a patient by a dosing regimen including a two-step process disclosed in the present invention, general anesthesia can be safely and promptly induced and maintained.
Patent EA-036448-B1 (EA)
Title: Bipyrazole derivatives as jak inhibitors
Inventor: LI YUN-LONG
IPC: C07D403/14
Filed: 2014-05-16
Abstract: The invention provides compounds of Formula Ior pharmaceutically acceptable salts thereof, where the meanings of radicals are defined in the claims. The invention also relates to compositions comprising compounds of Formula I and methods of use thereof in inhibiting the activity of Janus kinase (JAK) and in the treatment of diseases related to the activity of JAK including inflammatory disorders, autoimmune disorders, cancer, and other diseases.
Patent EA-035025-B1 (EA)
Title: Anti-c5 antibodies having improved pharmacokinetics
Inventor: ANDRIEN BRUCE A JR
IPC: A61P29/00
Filed: 2015-03-06
Abstract: The invention provides isolated antibodies or antigen-binding fragments thereof that bind to complement component human C5 and inhibit the cleavage of C5 into fragments C5a and C5b. Also provided are a nucleic acid encoding both a heavy chain polypeptide and a light chain polypeptide of said antibody or antigen-binding fragment thereof, an expression vector comprising the nucleic acid, a cell comprising the expression vector, a method for producing an antibody or antigen-binding fragment thereof, a pharmaceutical composition comprising the antibody or antigen-binding fragment thereof, a therapeutic kit comprising the antibody or antigen-binding fragment thereof, an article of manufacture. Furthermore, provided are methods for treating a patient suffering from paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome (aHUS) based on administering an antibody or antigen-binding fragment thereof or a pharmaceutical composition.
Patent EA-032097-B1 (EA)
Title: HETEROARYL Syk INHIBITORS
Inventor: DAHMANN GEORG
IPC: A61P11/06
Filed: 2015-03-12
Abstract: The invention relates to new substituted heteroaryls of formula 1wherein A is selected from the group consisting of N and CH, and Ris defined according to claim 1, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.
Patent EA-032800-B1 (EA)
Title: Method for manufacturing a recess plate
Inventor: BOEHNKE BERND
IPC: B01D25/00
Filed: 2014-12-22
Abstract: The present invention suggests a recess plate (1) designed for use in a filter device for filtering a suspension, the filter device having a stationary head piece and a movable end piece, a pack including copies of the recess plate (1), a filter chamber inside the pack, adjoining the recess plate (1), a first pipe for filling the suspension into the filter chamber, a filter cloth for collecting a solid content out of the suspension, and a second pipe for discharging a liquid fraction of the suspension out of the filter chamber as a filtrate, wherein the filter device may be closed before filtering by forcing the end piece in direction of the head piece, and opened after filtering by releasing the end piece, and moving the end piece away from the head piece for removing the filter cake from the filter cloth, wherein the recess plate (1) has a first surface (9) at the filter chamber and a second surface (10) vis-a-vis the first surface, wherein the first surface (9) and the second surface (10) are formed by sheets (2, 3), and the recess plate (1) has a rigid body (15) between the sheets (2, 3). The present invention further suggests a method for manufacturing the recess plate (1).
Patent EA-034606-B1 (EA)
Title: Method and device for separating composite materials and mixtures, in particular solid-material mixtures and slags
Inventor: GRAF DENIZ
IPC: B02C13/28
Filed: 2015-09-03
Abstract: The invention relates to a method for separating composite materials and mixtures, in particular solid-material mixtures and slags, and to a device for carrying out said method. The method for separating composite materials and mixtures comprises transporting the composite material or the mixture through a separating device. In this case, the composite material to be separated or the mixture to be separated is excited by mechanical pulses as it passes through the separating device and is thereby separated. The device (1) for carrying out the method comprises a drive unit (21) for driving a rotor element (32), which is connected to a bearing/shaft unit (22) and is part of a rotor unit (31). The rotor element itself has at least one rotor tool (33) and each rotor tool has at least one rotor tool component (34) and is surrounded by a stator element (42), which is part of a stator unit (41). The stator element itself has at least one stator tool (43) and each stator tool has at least one stator tool component (44). The rotor element and the stator element are substantially cylindrically formed.
Patent EA-035216-B1 (EA)
Title: Method for connecting piezoceramic substances with various materials
Inventor: KVASHENKINA OLGA EVGENIEVNA
IPC: B23K1/19
Filed: 2019-03-26
Abstract: The invention relates to the field of piezoelectronics, in particular to methods for connecting piezoceramic materials using reactive multilayer foils, and can find application in the manufacture of piezoceramic composite materials and multilayer ceramics, wiring of microwave devices, printed circuit boards and electronic components. The method of connecting piezoceramic materials involves the use of a reactive foil, 40-150 m thick, its layers made of 2-20 nm thick metals and/or non-metals selected from the group including nickel, aluminium, copper, niobium, cobalt, titanium, molybdenum, tantalum, carbon, silicon, boron; before applying the solder, an adhesive coating of 30 to 120 nm thickness is applied to the foil, after which a 2-15 m thick solder is applied, and the surfaces are pressed together at a pressure of 0.7-2.2 kg/cm(Fig. 1). In individual embodiments of the invention, before pressing surfaces together, the surfaces to be joined are preliminarily heated, in particular to a temperature not higher than the Curie temperature of the piezoceramic material and the melting temperature of the solder; the solder is applied galvanically, chemically or by spraying.