baber/WOPTO huggingface dataset:
Patent RU-2729998-C9 (RU)
Title: Method of producing (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide and its purification for use as
Inventor: PLATTSEK IOGANNES
IPC: C07D471/04
Filed: 2015-07-29
Granted: 2020-10-20
Abstract: FIELD: organic chemistry. 
     SUBSTANCE: invention relates to a method of producing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of formula (I), which comprises reacting a compound of formula (XIV) or (XIVa) with dimethyl sulphate to obtain a compound of formula (XV) or (XVa), which without recovery is directed to reduction using 1.21 eqv. REDAL (sodium bis(2-methoxyethoxy)aluminum dihydride) and 1.28 eqv. N-methylpiperazine to obtain an aldehyde of formula (XVI) or (XVIa), which is further added to the reaction without separation to obtain a nitrile of formula (VI), which is dissolved in 3–7-fold amount of isopropanol, 5–10 mol % piperidine and 5–10 mol % glacial acetic acid at 30 °C, is further reacted with a compound of formula (VII) to obtain a compound (VIIIa+b) which then reacts with 4-amino-5-methylpyridone to obtain compound (X), which is added to the reaction while stirring with 2.5–5 eqv. triethyl orthoacetate in dimethylacetamide at 100–120 °C for 1.5–3 hours to obtain a compound of formula (XI), which is saponified in 9-fold amount of a mixture of THF/water, having ratio of 2:1, aqueous sodium hydroxide solution to obtain a compound of formula (XII), which is then, without isolation of intermediate compounds, is first reacted in THF with carbodiimidazole and catalytic amounts of 4-(dimethylamino)pyridine, at the second stage is heated with reflux together with hexamethyldisilazane for 16–24 hours, and at the third stage is hydrolysed in water using THF or water to obtain a compound of formula (XIII), which is used at a step for chiral chromatography to obtain a compound of formula (I) in form of a solution in an inert solvent. Invention also relates to a method of producing a crystalline form of the compound of formula (I) and a method for preparing a medicinal agent based on the compound of formula (I) in crystalline form.  
     
       
       
       
       
       
       
       
       
       
       
     
     EFFECT: disclosed is an improved method of producing, which gives compound of formula (I) in 9 stages with total output of 27_7 % of theoretical without chromatographic purification of intermediate products. 
     3 cl, 10 dwg, 8 ex
Patent RU-2744327-C9 (RU)
Title: Способ флотационного обогащения калийных руд
Inventor: TITKOV STANISLAV NIKOLAEVICH
IPC: B03D1/02
Filed: 2020-03-24
Granted: 2021-04-28
Abstract: Предложенное изобретение относится к технологии переработки полезных ископаемых методом флотации, например, калийных руд. Способ флотационного обогащения калийных руд включает измельчение руды, флотационное обесшламливание руды с обработкой питания флотации шламов полиакриламидным флокулянтом и реагентом-собирателем шламов. В качестве собирателя шламов применяется оксипропилированный карданол с количеством оксипропильных групп от 10 до 70 или смесь оксиэтилированного и оксипропилированного карданола с количеством оксиэтильных и оксипропильных групп от 10 до 70. Технический результат - повышение селективности и эффективности флотируемости шламов из калийных руд, снижение потерь хлористого калия со шламовым продуктом, уменьшение содержания нерастворимых примесей в питании последующей сильвиновой флотации. 1 табл., 3 пр.
Patent DK-30285-D0 (DK)
Inventor: GRUETZNER HANS
IPC: A47H5/032
Filed: 1985-01-23
Abstract: A tensioning device for use with an endless traverse which is longitudinally adjustable in both directions responsive to a rotational drive. The rotational drive includes two driving gears which are each selectively coupled with a drive shaft so that when one of the driving gears is positively driven, the other driving gear is permitted to rotate freely. The traverse changes from one driving gear to the other by passing from between a pair of overlying side walls and over a flange. Elongation resulting from strain of the traverse is continuously led out of the system so that blocking or braking of the traverse is avoided. The tensioning device is especially suitable for the operation of strip curtains or conventional curtains, as well as for curtain systems with large and heavy traverses.
Patent DK-146790-D0 (DK)
Inventor: WOLFF PER
IPC: A61L29/14
Filed: 1990-06-15
Abstract: A medical instrument comprising an instrument core having alubricious coating when wet, said coating comprising a first layer in direct surface contact with said instrument core and formed from a dried aqueous emulsion of a water-insoluble latex polymer, and a second layer comprising a dried aqueous solution of a water-soluble hydrophilic polymer. <IMAGE>
Patent DK-249585-D0 (DK)
Inventor: SCHULZE ERNST-FRIEDRICH
IPC: A01N43/50
Filed: 1985-06-03
Abstract: Plant growth regulators comprising a compound of the formula I <IMAGE>  (I)  wherein x=0, S or N, R1=hydrogen, phenyl, alkenyl or (substituted) alkyl and, when X=0 or S, also a metal cation or ammonium cation, n=1 when X=0 or S, and 1 or 2 when X=N, R2 and R3=alkyl, R4=alkyl, alkoxy or halogen and m=0, 1, 2 or 3, and, when R1 does not represent a cation, their acid addition salts, complex salts or quaternization products, in combination with a compound of the formula II R-CH2-CH2-N+(CH3)3Cl-(II) wherein R denotes OH or Cl, or in combination with N,N-dimethylpiperidinium chloride.
Patent DK-310884-D0 (DK)
Inventor: MANLOW TERENCE VICTOR
IPC: E21D11/08
Filed: 1984-06-26
Abstract: A method of constructing a lined or relined tunnel utilizes four lining segments, three of which (1, 2, 3) have a longer arcuate length than the fourth (4). The tunnel is constructed within a shield (20) having a tubular member (21) and a curved build plate (22) having a minimum internal dimension at least the same as the outside radius of the lining. The shield also has a circular skirt (25) the upper part of which is extended rearwardly to form a hood (26). In the method a length of tunnel is excavated and the shield positioned therein, a first segment (1) is positioned on the build plate and the segments (2, 3) then located upon the first segment (1). The ends of the second and third segments (2, 3) remote from the segment (1) are pivoted outwardly to locate the fourth segment (4). The shield is provided with a flexible collar (27) extending from the confluence of the member (21) and skirt (25) interiorly of the shield to provide a seal between the lining segments and the collar against filler material (40), the collar having an L-shape for clampingly securing the collar to the tubular member and skirt combination.
Patent DK-587589-D0 (DK)
Inventor: FRANK MARGARET A
IPC: A61F13/00
Filed: 1989-11-22
Abstract: In accordance with the present invention a novel composite compression and support dressing is disclosed. This dressing comprises an extensible bandage having a stretchable hydrocolloid adhesive composition laminated thereto.
Patent DK-603388-D0 (DK)
Inventor: CHAMPESEIX HENRI
IPC: G01N1/00
Filed: 1988-10-28
Abstract: The central valve assembly, which consists of an element sliding between two non-moving guide pieces 2 placed on either side, is held on four of its surfaces by a lower guide 7, an upper guide 8, a metal sheet 10 and an end block 11, which are non-moving members; the assembly is held at its end by means of a manually releasable end clamp 14 and on one side by a rocker 18 pulled by a spring 26 against the lateral surface of a non-moving guidepiece 2. 
<??>Application to blood sampling valves. 
<IMAGE>
Patent HU-913055-D0 (HU)
Title: An improved method for producing 4-methyl-sulfonyl-benzoic acid derivatives and their intermediate products
Inventor: GREGORY JULIAN ANTHONY
IPC: C07C317/44
Filed: 1991-09-25
Abstract: This invention relates to an improved process for preparing an herbicidal intermediate compound having the structural formula:- <CHEM> wherein groups X are independently selected from alkyl, haloalkyl, CN, halo, alkoxy, nitro, or S(O)mR<2> where R<2> is alkyl and m is 0, 1 or 2, n is 0 or an integer of from 1 to 4 and R<5> is hydrogen or C1-6 alkyl and intermediate compounds.
Patent NO-872110-D0 (NO)
Inventor: STARK JOHN HERMAN
IPC: F04F5/44
Filed: 1987-05-20
Abstract: PCT No. PCT/CH86/00132 Sec. 371 Date May 19, 1987 Sec. 102(e) Date May 19, 1987 PCT Filed Sep. 19, 1986 PCT Pub. No. WO87/01770 PCT Pub. Date Mar. 26, 1987.A device for creating a pressure difference in the flow of a fluid which may be a liquid or a gas and a number of technical applications. The fluid medium is fed along the longitudinal axis of a double cone, consisting of two coaxial hollow cones linked by their smallest faces. At the narrowest point of the double cone a depression occurs in the fluid flow which is made accessible to the outside by means of a lateral connection piece. Compared with a conventional venturi the present double cone offers increased efficiency owing to its special shape, which is defined by geometric parameters. The high efficiency of the double cone, which can be further improved by a special embodiment, makes the device suitable for a number of technical applications.
Patent NO-883044-D0 (NO)
Inventor: BOWMAN ROBERT M
IPC: C07D471/04
Filed: 1988-07-07
Abstract: Disclosed are 1,2-benzisoxazole and 1,2-benzisothiazole derivatives represented by formula I    <IMAGE>  (I)  wherein X represents oxygen or sulfur; Z rep;esents carbon (CH) so as to complete the imidazol-1-yl ring radical or Z represents nitrogen (N) so as to complete the 1,2,4-triazol-1-yl ring radical; R1 represents hydrogen, lower alkenyl, lower alkynyl, aryl-lower alkyl or lower alkyl; R2 represents hydrogen, lower alkenyl, lower alkynyl, aryl-lower alkyl or lower alkyl; or R1 and R2 combined represent lower alkylene; or R1 combined with R5 located on the Z-carbon atom of the imidazolyl radical represents C2-C4-alkylene; R3 and R4 independently represent hydrogen, lower alkyl, cycloalkyl, halogen, trifluoromethyl, cyano, nitro, amino, hydroxy, lower alkanoyloxy, carbocyclic aroyloxy, lower alkoxy, or carbocyclic aryl; or R3 and R4, together when located on adjacent carbon atoms, represent lower alkylenedioxy; or R3 and R4, together when located on the carbon atoms to which attached a benzo-fused or C5-C7-cycloalka-fused ring, respectively; R5 located on carbon represents hydrogen, lower alkyl or hydroxy-lower alkyl; R6 located on carbon represents hydrogen or lower alkyl; or when Z represents carbon, R5 located on the Z-carbon atom combined with R6 located on the adjacent carbon atom represents C3-C5-alkylene; and pharmaceutically acceptable salts thereof; which are active in mammals as anticonvulsant agents.
Patent NO-901176-D0 (NO)
Inventor: OHNO KIYOTAKA
IPC: A61P33/10
Filed: 1990-03-13
Abstract: Compounds of the following formula <CHEM> are stable and potent analogues of prostacyclin. e
Patent NO-911848-D0 (NO)
Inventor: BARBI GIAMPAOLO
IPC: C08L23/00
Filed: 1991-05-13
Abstract: Nonextruded concentrates in particle form, each particle comprising:     A) a matrix consisting of a nonextruded particle of an olefin polymer or copolymer, having a porosity, expressed in percentage of voids on the volume of the particle, higher than or equal to 15%; B) one or more additives, pigments or fillers, or combinations thereof, deposited on the surface of the matrix (A) and/or inside its pores. The concentrates are used in the processing of polyolefins. n
Patent NO-922211-D0 (NO)
Inventor: SMITH JAMES W
IPC: B01D53/34
Filed: 1992-06-04
Abstract: Hydrogen sulfide or other gaseous component is removed from a gas stream containing the same by distribution of the gas stream in the form of fine bubbles by a rotary impeller and stationary shroud arrangement at a submerged location in an aqueous iron or other transition metal chelate solution, or other suitable catalyst, contained in an enclosed reaction vessel. Sulfur particles, or other insoluble phase product, of narrow particle size range formed in the reaction are floated off from the iron chelate solution. An oxygen-containing gas stream also is distributed in the form of fine bubbles by a separate rotary impeller and stationary shroud arrangement at a separate submerged location in the iron chelate solution. The second submerged location is separated from the first by a bafle extending downwardly in the reaction vessel from a top closure towards a bottom closure.
Patent NO-924136-D0 (NO)
Inventor: MARTIN BARRY JOHN
IPC: H04R17/00
Filed: 1992-10-26
Abstract: Ultrasonic piezoelectric transducer comprising a piezoelectric material (10) having a profile whereby the transducer transmits and/or receives ultrasonic vibrations in a dilational (quasilongitudinal) mode. The profile is curved and includes a point of inflection. Possesses a vibrational peak in the frequency range 10 KHz - 200 KHz. Construction is performed via profiling and tensioning the piezoelectric material.
Patent NO-931085-D0 (NO)
Inventor: MOLIN GJOERAN
IPC: A61K35/74
Filed: 1993-03-24
Abstract: A process for isolation of a strain of Lactobacillus having the ability of being established on human intestinal mucosa in vivo and being able to remain therein after oral administration for at least 10 days after the completion of the administration. By the process the new strains L. plantarum 299 (DSM 6595) and L. casei ssp. rhamnosus 271 (DSM 6594) have been isolated, which are useful for the prophylaxis or treatment of bacterial infections, especially in the form of a fermented nutrient composition.
Patent NO-950733-D0 (NO)
Inventor: FISCHER BERNHARD
IPC: C07K1/18
Filed: 1995-02-27
Abstract: A process for the sepn. of vitamin=K dependent proteins from non-vitamin=K dependent proteins by the addn. of Ca<2+> to a protein-contg. soln., and contacting the soln. with an anion exchanger so that all proteins except the vitamin=K-dependent ones are adsorbed is claimed.
Patent NO-951688-D0 (NO)
Inventor: GERMOND JACQUES-EDOUARD
IPC: A61K8/00
Filed: 1995-05-02
Abstract: The invention relates to two new Streptococcus thermophilus bacteriocins having the amino acid sequences SEQ ID NO:1 and SEQ ID NO:2, the signal peptides for these two bacteriocins, the nucleotide sequences encoding these bacteriocins especially an operon encoding the said bacteriocins having the sequence SEQ ID NO:3, the strains producing at least one of these bacteriocins, especially the strain CNCM 1-1351, a method for producing a supernatant extract comprising at least one of these two bacteriocins, and a use of these bacteriocins in the preparation of food products especially cheeses and acidified milks, and of cosmetic products as active agent against pathogens.
Patent NO-964059-D0 (NO)
Inventor: ALOUP JEAN-CLAUDE
IPC: A61P9/10
Filed: 1996-09-26
Abstract: PCT No. PCT/FR95/00359 Sec. 371 Date Sep. 27, 1996 Sec. 102(e) Date Sep. 27, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26342 PCT Pub. Date Oct. 5, 1995Compounds of formula (I): wherein R represents a CR4R5, CHR6, or C=R7 radical and R3 represents an oxygen atom, salts thereof, the preparation thereof and drugs containing same. The compounds of formula (I) have valuable pharmacological properties and are alpha-amino-3-hydroxy-5-methyl-4-osoxaziepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and particularly NMDA receptor glycine modulation site ligands.
Patent NO-970601-D0 (NO)
Inventor: FLEISCH THEODORE H
IPC: C10L1/02
Filed: 1997-02-10
Abstract: A diesel fuel composition comprising from about 70 to about 95 weight percent of dimethyl ether, up to about 20 weight percent of methanol, and from about 0.1 to about 20 weight percent of water is disclosed.
Patent NO-971316-D0 (NO)
Inventor: SMITH ADRIAN E
IPC: A61M15/00
Filed: 1997-03-20
Abstract: A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.
Patent NO-973596-D0 (NO)
Inventor: LUND GERRIT
IPC: D21C9/00
Filed: 1997-08-05
Abstract: In a process for making paper pulp containing fibres from annual plants or secondary products, the fibres are shortened before the bleaching stage to a length which enables a homogeneous, pumpable suspension of them to be prepared. Also claimed is a process in which the fibres and the water are simultaneously introduced into a mixing device, briefly centrifuged, and fed to a refiner. Further claimed is a similar process in which the fibres are shortened to a length which enables a suspension of them to be processed in conventional pumps.
Patent NO-981189-D0 (NO)
Inventor: LOWELL GEORGE H
IPC: A61P31/04
Filed: 1998-03-17
Abstract: A method for preparing multivalent proteosomeamphiphilic determinant vaccines suitable for parenteral or mucosal administration using diafiltration or ultrafiltration technology. The amphiplilic determinants include lipopolysaccharides from gram negative bacteria, e.g. S. flexneri, P. shigelloides and S. sonnei. Proteosomes are obtained from group B type 2b meningococci. The active proteosomeamphiphilic determinant complexes (noncovalently complexes) of the vaccine are formed using defiltration or ultrafiltration to remove the detergent. The use of diafiltration or ultrafiltration decreases processing time and the opportunity for contamination and further permits the use of ambient temperature and efficient scaleup. In addition, the process permits the reliable and continuous monitoring of the dialysate which enhances the efficiency of the entire process. The time of dialysis for production of a lot of vaccine is reduced from 710 days to less than 72 hours and usually less than 48 or 4 hours. The use of the process optimizes the presence of each antigenic component in the preparation of multivalent vaccines.
Patent NO-992709-D0 (NO)
Inventor: MONTESSORO EZIO
IPC: C07C409/16
Filed: 1999-06-03
Abstract: A process for the di-ter-peroxide synthesis, wherein the condensation reaction between a tertiary hydroperoxide and a tertiary alcohol is carried out in the presence of an acid catalyst, constituted by a compound having a mono-sulphonated aromatic ring selected from the following formulae: <CHEM> wherein: R is an alkyl group having from 2 to 9 carbon atoms, preferably from 2 to 6; R'and R'' are alkyl groups having a number of from 1 to 9 carbon atoms, preferably from 1 to 6.
Patent GB-0007412-D0 (GB)
Title: Information processing system
IPC: G06F11/00
Filed: 1996-07-08
Abstract: A TMR unit connects a plurality of processors by a bus and simultaneously executes the same processing operation. Among the plurality of processors, one of them is a master and the remaining processors are slaves. Information formed by only the master processor is outputted to the bus. Each processor has a multiplex control circuit. The multiplex control circuit compares output information formed by itself with bus information outputted to the bus, thereby detecting a failure and allowing an internal circuit to execute necessary processes.
Patent GB-0011451-D0 (GB)
Title: Fluorometric method for monitoring and detecting nucleic acid amplification
IPC: C12Q1/68
Filed: 1998-11-27
Abstract: A method for monitoring a reaction within a sample, said method comprising supplying or forming a double stranded polynucleotide having a fluorescence donor and a fluorescence acceptor molecule spaced along the length at a distance at which fluorescence from the donor is reduced by the acceptor, applying to said molecule a restriction enzyme which cuts said polynucleotide at a site intermediate said donor and said acceptor molecule, and monitoring fluorescence of said sample.  The method is particularly suitable for detecting polynucleotide amplification, in particular in sequence detection but may also be used in enzyme quality control.
Patent GB-0020331-D0 (GB)
Title: Enzyme
IPC: C12N15/56
Filed: 2000-08-17
Abstract: Amino acid sequences and nucleotide sequences relating to aphid myrosinase are described. In a preferred aspect, the amino acid sequence comprises the sequence presented as SEQ ID No. 1.
Patent GB-0116620-D0 (GB)
Title: Formulation
IPC: A61K47/10
Filed: 2001-07-07
Abstract: The invention relates to a pharmaceutical formulation, preferably adapted for administration by injection, containing the compound 7a-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17beta-diol and an antioxidant, more particularly to a formulation adapted for administration by injection containing the compound 7a-[9-(4,4,5,5,5-pentafluoropentyl-sulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17beta-diol in solution in a ricinoleate vehicle which comprises an antioxidant.
Patent GB-0207533-D0 (GB)
Title: Protein
IPC: A61K48/00
Filed: 2002-04-02
Abstract: The present invention relates to new uses of Solute Carrier 6 (SC6), a taurine transporter, in the diagnosis, screening, treatment and prophylaxis of hypoxia related conditions e.g. cancer. Compositions comprising the protein, such as vaccines and agents that modulate the protein expression or activity, including antibodies that are immunospecific for the protein, are also provided.
Patent GB-0211980-D0 (GB)
Title: Safety barrier apparatus
IPC: E04G21/32
Filed: 2002-05-23
Abstract: Safety barrier apparatus especially for provision of a safety barrier around the edges of a partially-completed stairwell in a building under construction or renovation comprises rail members (25,26,27,28) and means (16,17,18,19) to support the rail members (25,26,27,28) spaced from the floor, the rail members (25,26,27,28) being length-adjustable and pivotably attachable to the support means (16,17,18,19). The support means (16,17,18,19) comprise an optionally height-adjustable leg member attached or attachable to a foot member (20,21) for temporary engagement with the floor or adapted for mounting on or attachment to a newel post or for attachment to a wall. <IMAGE>
Patent GB-0306227-D0 (GB)
Title: Positioning device for use in radiography
IPC: G03B42/02
Filed: 2003-03-19
Abstract: An X-ray cassette or a radiographic grid and X-ray cassette is (are) mounted within a device for positioning the cassette or grid and cassette beneath a patient lying upon a bed or other support to enable an X-ray image of a portion of the patient to be taken. The device has a plastics envelope formed of a material that is both substantially radiotranslucent and impervious to water or other biological fluids. This envelope defines first and second envelope sections separated from each other by a common edge. The first envelope section is generally rectangular in configuration and defines an openable pouch in which the X-ray cassette or radiographic grid and X-ray cassette are received. The second envelope section has a stiffening member therein. The second envelope section has its greatest width along the common edge and narrows to a minimum width at its edge furthest from the common edge. The stiffening member within the second envelope section is generally wedge shape in section, whereby the second envelope section has a thickness that tapers from a maximum thickness approximating the thickness of the radiographic grid and X-ray cassette at its greatest width adjacent the common edge to a minimum thickness at the furthest edge.