Patent SG-11201810366W-A (SG)
Title: 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides
Inventor: SCHMEES NORBERT
IPC: C07D403/12
Filed: 2017-05-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0 DOI 010111110101111 0 01010 1101 OH HI 111110 lil OE lil Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\"\") WO 2017/202816 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, CO7D 237/16 (2006.01) CO7D 405/12 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, CO7D 237/20 (2006.01) A61P 35/00 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. C07D 403/12 (2006.01) A61K 31/501 (2006.01) (84) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of regional protection available): ARIPO (BW, GH, PCT/EP2017/062355 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (22) International Filing Date: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 23 May 2017 (23.05.2017) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (25) Filing Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (26) Publication Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (30) Priority Data: PCT/CN2016/083308 Declarations under Rule 4.17: 25 May 2016 (25.05.2016) CN — as to applicant's entitlement to apply for and be granted a PCT/CN2017/074408 patent (Rule 4.17(0 22 February 2017 (22.02.2017) CN Published: (71) Applicants: BAYER PHARMA AKTIENGESEL- — with international search report (Art. 21(3)) LSCHAFT [DE/DE]; MilllerstraBe 178, 13353 Berlin (DE). DEUTSCHES KREBSFORSCHUNGSZEN- TRUM (DKFZ) [DE/DE]; Im Neuenheimer Feld 280, 69120 Heidelberg (DE). (72) Inventors: SCHMEES, Norbert; Bondickstr.61, 13469 Berlin (DE). GUTCHER, Ilona; Paul-Robeson-Str. 28, 10439 Berlin (DE). IRLBACHER, Horst; Winsstrasse 47, 10405 Berlin (DE). BADER, Benjamin; Hillmannstr. 14, 13467 Berlin (DE). ZHAO, Na; Nanhai Community, Shan- haizi east Road, BDA, Beijng, 100076 (CN). PLATTEN, Michael; Cambridgestr. 7, 69115 Heidelberg (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein (DE). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = (81) (54) Title: 3-OXO-2,6-DIPHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES (57) : The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carbox- RS compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined here- R 4 R 6 pounds, pharmaceutical compositions and combinations comprising said compounds and the use of go in, methods of preparing said compounds, intermediate compounds useful for preparing said com- said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis 1-1 GC of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other N N' disorders associated with aberrant AHR signaling, as a sole agent or in combination with other ac- 0 ei /0 tive ingredients. IN Il 14111 H N. R 1 0 ei (I) O