baber/WOPTO huggingface dataset:
Patent CA-2617964-A1 (CA)
Title: Azole and thiazole derivatives and their uses
Inventor: FINCH HARRY
IPC: C07D277/30
Filed: 2006-08-08
Abstract: Compounds of formula (I) are useful in the treatment of diseases where enhanced M3 receptor activation is implicated, such as respiritory tract diseases: wherein (i) R1 is C1-C6-alkyl or hydrogen; and R2 is hydrogen or a group -R7, -Z-Y-R7, -Z-NR9R10; -Z-CO-NR9R10, -Z-NR9-[AE11]C(O)O-R7, or -Z-C(O)-R7; and R3 is a lone pair, or C1C6-alkyl; or (ii) R1 and R3 together with the nitrogen to which they are attached form a heterocycloalkyl ring, and R2 is a lone pair or a group -R7, -Z-Y-R7, -Z-NR9R10, -Z-CO-NR9R10, -Z-NR9-[AE12]C(O)O-R7; or; -Z-C(O)-R7; or (iii) R1 and R2 together with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring being substituted by a group -Y-R7, -Z-Y-R7, -Z-NR9R10; -Z-CO-NR9R10; -Z-NR9-[AE13]C(O)O-R7; or; -Z-C(O)-R7; and R3 is a lone pair, or C1-C6-aIkyl; R4 and R5 are independently selected from the group consisting of aryl, arytfused-heterocycloalkyl, heteroaryl, C1-C6-alkyl, cycloalkyl; R6 is -OH, C1-C6-alkyl, C1-C6-alkoxy, hydroxy-C1-C6-alkyl, nitrile, a group CONR8 2 or a hydrogen atom; A is an oxygen or a sulfur atom; X is an alkylene, alkenylene or alkynylene group; R7 is an C1-C6-alkyl, aryl, aryl-fused-cycloalkyl, aryl-ffused-heterocycloalkyl, heteroaryl, aryl(C1-C8-alkyl)-, heteroaryl(C1-C8-alkyl)-, cycloalkyl or heterocycloalkyl group; R8 is C1-C6-alkyl or a hydrogen atom; Z is a C1-C16-alkylene, C2-C16-alkenylene or C2-C16-alkynylene group; Y is a bond or oxygen atom; R9 and R10 are independently a hydrogen atom, C1-C6-alkyl, aryl, aryl-fused-heterocycloalkyl, aryl-fused-cycloalkyl, heteroaryl, aryl(C1-C6-alkyl)-, or heteroaryl(C1-C6-alkyl)- group; or R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring of 48 atoms, optionally containing a further nitrogen or oxygen atom.
Patent CA-2619785-A1 (CA)
Title: Sustained release of a cell growth factor from a tissue regeneration substrate comprising collagen and gelatin
Inventor: SUZUKI SHIGEHIKO
IPC: C12N5/071
Filed: 2006-09-05
Abstract: A tissue regeneration substrate that is capable of sustained release of a cell growth factor, such as basic fibroblast growth factor (bFGF), and that ensures easy infiltration of cells therein, being suitable for tissue regeneration. In particular, there is provided a tissue regeneration substrate comprising a bioabsorptive porous substrate containing collagen and gelatin and, contained therein, a cell growth factor, and provided a process for producing the same.
Patent CA-2621457-A1 (CA)
Title: Method and apparatus for continuously preparing crosslinked, solution-cast polymer film
Inventor: VERRALL ANDREW P
IPC: C08J3/24
Filed: 2006-10-11
Abstract: A method and system for continuously preparing a crosslinked, solvent-cast film are disclosed. The method includes continuously providing a pressurized stream of polymer solution, continuously combining a fluid stream including a crosslinking agent with the pressurized stream of polymer solution, mixing the combination of polymer solution and fluid stream in-line, continuously applying the resulting mixture to a continuously moving surface, and then evaporating solvent from the mixture to form a polymeric film. The system includes: (i) a continuous polymer solution casting system, including a first pump in fluid communication with a supply of polymer solution, a casting die for continuously depositing polymer solution disposed in proximity to a moving casting surface, and a first conduit providing a flow path for the polymer solution from the pump to the casting die; (ii) a secondary liquid component injection system, including a second reservoir for holding a supply of a secondary liquid component including a crosslinking agent, a variable-speed second pump in fluid communication with the supply of secondary liquid component, a needle valve, and a second conduit providing a flow path for the secondary liquid component from the reservoir, through the second pump, then through the needle valve, and to an outlet; (iii) a conduit junction connecting the outlet of the secondary liquid component injection system to the first conduit of the continuous polymer solution casting system, the junction disposed downstream of the first pump; and (iv) an in-line mixer disposed between the casting die and the conduit junction.
Patent CA-2621716-A1 (CA)
Title: Methods and compositions to improve mouth feel
Inventor: LIAO SHYHYUAN
IPC: A23L29/238
Filed: 2006-09-12
Abstract: Free-flowing powdered or granular low calorie sweetener compositions containing a high intensity sweetener and a food-grade gum are provided. These compositions, when added to a solid food or beverage provide improved mouth feel without significant caloric impact. Methods of producing these sweetener compositions and kits that incorporate such compositions are also provided.
Patent CA-2623745-A1 (CA)
Title: Hexahydro-cycloheptapyrazole cannabinoid modulators
Inventor: LIOTTA FINA
IPC: C07D401/12
Filed: 2006-09-18
Abstract: This invention is directed to a hexahydro-cycloheptapyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
Patent CA-2623779-A1 (CA)
Title: Solid ink stick with reversible keying and interlocking features
Inventor: FAIRCHILD MICHAEL A
IPC: B41F7/02
Filed: 2008-03-03
Abstract: An ink stick for use in an ink delivery system of a phase change ink imaging device comprises an ink stick body having first and second opposed end surfaces and first and second opposed lateral side surfaces. The ink stick body is rotationally symmetric about a vertical central axis of the ink stick body. The ink stick body includes an interlocking face on the first end surface and a complementarily shaped interlocking face on the second end surface. A key is on each of the first and second side surfaces. The keys of the first and second side surfaces are similarly shaped. The key on the first side surface and the key on the second side surface are rotationally symmetrically positioned with respect to each other about the vertical central axis.
Patent CA-2624132-A1 (CA)
Title: Enhancing enzyme production
Inventor: PATANE MICHAEL
IPC: A01H5/10
Filed: 2006-08-25
Abstract: The invention relates to a process for increasing the amount of enzymes in a grain by germinating the grain in conditions in which the grain is wounded.  The invention also relates to hydrolases obtainable from grains for use in food processing and manufacturing industries, to the germination of grains such as barley and to isolation of enzymes from grains.
Patent CA-2625104-A1 (CA)
Inventor: JONES BRADEN L
IPC: B02C18/24
Filed: 2008-03-10
Abstract: A hand-held shredding device is provided including a housing sized and configured to be hand-held. The housing may include a first opening configured to receive an object to be shredded and a second opening configured to allow the object to exit the housing upon being shredded. A shredding assembly may be disposed within the housing. The shredding assembly may include a first plurality of blades disposed on a first rotatable shaft and a second plurality of blades disposed on a second rotatable shaft.  The first and second rotatable shafts may be coupled to one another through a geared connection. The first and second pluralities of blades may be arranged to cooperate with one another to shred the object. A hand-operable crank may be connected to an end of one of the first or second rotatable shafts of the shredding assembly. The hand-operable crank may be configured to be operable by a user's hand to rotate one of the first or second rotatable shafts and thereby provide power to the shredding assembly to contemporaneously shred the object while moving the object towards the second opening.
Patent CA-2625841-A1 (CA)
Title: Centrifugal separator of heavier particulate materials from light particulate materials in a slurry using a stepped lead-in surface
Inventor: SIMPSON PETE
IPC: B04B7/08
Filed: 2008-03-27
Abstract: A centrifuge bowl for separating heavier particles from lighter particles and water comprises a conical lead-in wall leading of the bowl to a single recess or a pair of annular recesses at axially spaced positions. Each recess is generally V-shaped with an upper side wall, a lower side wall and a base. The base contains a plurality of angularly spaced valve controlled discharge ducts each having a mouth projecting through the base into the interior of the bowl for discharging the heavier particles in a continuous operation. The lead-in surface is stepped to cause tumbling of the flowing feed materials. The recess or recesses contain a concentrator ring which projects into the recess toward the base to reduce the amount of concentrate in the recess.
Patent CA-2627659-A1 (CA)
Title: Internal combustion engine with breather system
Inventor: TSUBAKINO YUKIHIRO
IPC: F01M13/04
Filed: 2008-03-25
Abstract: An object of the present invention is, in a breather system in which gas-liquid separation is performed by utilizing the rotation of a camshaft, to improve the gas-liquid separating function in a breather chamber, and also to reduce the number of components of the breather system and further the size of the internal combustion engine in the axial direction of the camshaft. Provided is an internal combustion engine including a valve system and a breather system. The valve system includes a camshaft provided with intake cams as well as exhaust cams. The intake cams open and close intake valves, respectively, while the exhaust cams open and close exhaust valves. The breather system is provided with an upstream-side breather chamber and a downstream-side breather chamber. Blow-by gas flows into the upstream-side breather chamber through a chain chamber. The breather chamber is provided in the camshaft, and also formed of a through hole constituted of a plurality of hole portions. The hole portions have different sizes and are aligned in the axial direction. The through hole opens to the chain chamber at a first shaft end portion of the camshaft, and also opens to the breather chamber at a second shaft end portion of the camshaft. The breather chamber is formed of a cam holder.
Patent CA-2628105-A1 (CA)
Inventor: AUKERMAN SHARON LEA
IPC: A61K39/395
Filed: 2006-11-01
Abstract: Methods for treating a human patient for a cancer or pre-malignant condition that is associated with CD40-expressing cells are provided, where the human patient is heterozygous or homozygous for Fc.gamma.RIIIa-158F (genotype V/F or F/F). Also provided are methods of inhibiting antibody production by B cells in a human patient who is heterozygous or homozygous for Fc.gamma.RIIIa-158F  (genotype V/F or F/F). The methods comprise administering to the human patient a therapeutically or prophylactically effective amount of an anti-CD40 antibody. Methods and kits for identifying a human patient with a cancer or pre-malignant condition that is treatable with an anti-CD40 antibody and which is refractory to treatment with rituximab (Rituxan~), as well as methods and kits for selecting an antibody therapy for treatment of a human patient having a cancer or pre-malignant condition that is refractory to treatment with rituximab (Rituxan~), are also provided. The methods of the present invention find use in treatment of cancers and pre-malignant conditions that are associated with CD40-expressing cells. These methods are particularly advantageous with respect to cancers and pre-malignant conditions that are associated with cells expressing both CD40 and CD20, as the methods enable the treatment of patients having a cancer or pre-malignant condition that is refractory to therapy with other oncotherapeutic agents such as anti-CD20 antibodies.
Patent CA-2630201-A1 (CA)
Inventor: RADKE EDWARD F
IPC: F22B37/24
Filed: 2008-05-01
Abstract: A link-type seismic tie is provided between a steel structural support and a buckstay, and includes two horizontally arranged, parallel, and spaced apart link members, which are connected at their ends to large vertical pins. Each of the link members includes two horizontally arranged and parallel longitudinal outboard stringers and a horizontally arranged and parallel longitudinal center stringer centered between the two outboard stringers. Each link member further includes finger plates standing upright and spaced apart from each other relatively perpendicular to the longitudinal stringers. The finger plates are held between each of the outboard stringers and the longitudinal center stringer. A gusset plate connects the outboard stringers to a pin plate, which is connected to a large pin at the buckstay. The other end of the link members is connected to a large pin at the steel structural support via the ends of the outboard stringers.
Patent CA-2631853-A1 (CA)
Inventor: NESI MARCELLA
IPC: A61K31/5355
Filed: 2006-12-06
Abstract: Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.
Patent CA-2634324-A1 (CA)
Title: A process for preparing a rejuvenated epoxidation catalyst
Inventor: EVANS WAYNE ERROL
IPC: B01J23/66
Filed: 2006-12-20
Abstract: A process for preparing a rejuvenated epoxidation catalyst, for the epoxidation of one or more olefins using the rejuvenated epoxidation catalyst to produce olefin oxide, and for the production of a 1,2-diol, a 1,2-diol ether, or an alkanol amine from the olefin oxide, the process comprising: providing a quantity of spent epoxidation catalyst having a cumulative alkylene oxide production of 0.16 kT/m3 of the spent epoxidation catalyst or more; and, depositing additional silver on the spent epoxidation catalyst in an amount of 0.2 %w or more, based on the weight of the spent epoxidation catalyst.
Patent CA-2636606-A1 (CA)
Inventor: HENION GEORGE
IPC: G06T13/80
Filed: 2007-01-20
Abstract: A system and method for confirming touch input with a touch-sensitive display that includes detecting contact with a touch-sensitive display at coordinates corresponding with a control, An animated rendering on the touch-sensitive display is displayed, and an action is performed at a conclusion of the animated rendering if contact with the touch-sensitive display at the coordinates corresponding with the control is detected throughout a time period extending from initiation to the conclusion of the animated rendering.
Patent CA-2637563-A1 (CA)
Title: A method and apparatus for creating contextualized auction feeds
Inventor: PITKOW JAMES EDWARD
IPC: G06Q40/00
Filed: 2007-02-16
Abstract: A method and apparatus is disclosed herein for generating contextualized live auction feeds. The method of generating contextualized live auction feeds comprises receiving context data from a user. The method further comprises utilizing the context data received from the user to search auctions. The method, in one embodiment, includes generating contextualized live auction feeds for an auction based on the context data.
Patent CA-2638201-A1 (CA)
Title: Syringe and method for dosed dispensing of materials
Inventor: PLAUMANN MANFRED THOMAS
IPC: A61C5/62
Filed: 2008-07-18
Abstract: The invention relates to a syringe (1) for dosed dispensing of material, i n particular of free-flowing and/or pasty dental material, comprising a sleeve (10) for accommodating material and a piston (15) which can be inserted into the sleeve (10) and which comprises a piston member (15'), a frictional engageme nt element (25) which abuts an inner wall (35) of the sleeve (10), and an elast ic element (30) coupling the frictional engagement element (25) and the piston member (15'), wherein the sleeve (10) and the piston (15) inserted into the sleeve (10) define an inner sleeve chamber (70) for accommodating the material, wherein the elastic element (30) can be tensioned, on insertion of the pisto n (15) and/or of the piston member (15') into the sleeve (10), by means of a relati ve lag of the frictional engagement element (25) in relation to the piston member (15'), wherein by relaxing the elastic element (30) it is possible for the piston member (15') to be expelled at least partially from the sleeve (10) while the frictional engagement element (25) remains motionless, in order to increase the volume of the inner sleeve chamber (70). The invention also relates to a corresponding method, a piston (15) and a frictionally engaging elastic element (20).</SDO AB>
Patent CA-2638452-A1 (CA)
Title: High quality ultra-thin gate dielectric
Inventor: MORADI MARYAM
IPC: H01L29/24
Filed: 2008-08-19
Abstract: Disclosed is an ultra-thin (-50nm) silicon nitride (SiN x) dielectric demonstrating low leakage current density (e.g. 0.1 nm/cm2 ) and high breakdown voltage (e.g. 5.6 MV/cm), highly suitable as a gate dielectric in a broad variety of thin film transistor technologies. The gate dielectric thickness can be scaled to even thinner values without compromising on gate leakage.
Patent CA-2638842-A1 (CA)
Inventor: LAIR JEAN-PIERRE
IPC: F02K1/56
Filed: 2008-08-18
Abstract: A pivot arrangement for a thrust reverser door of a gas turbine engine, the pivot fitting having a base and a shaft projecting from a main side of the base.  The shaft receives a preferably curved pivot arm of the door to provide a low profile arrangement which improves performance when the doors are stowed.
Patent CA-2640171-A1 (CA)
Title: 6-modified bicyclic nucleic acid analogs
Inventor: SETH PUNIT P
IPC: C07H19/04
Filed: 2007-01-27
Abstract: The present invention provides 6-Modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclic-nucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.
Patent CA-2641089-A1 (CA)
Title: Multiple height fluid mixer and method of use
Inventor: BROGDON JAMES W
IPC: B01F23/10
Filed: 2008-10-15
Abstract: A mixer assembly (204, 603) for mixing intake air from an intake system (124) with exhaust gas from an exhaust gas recirculation system (134) to yield a mixture stream includes an intake air conduit (202, 700) having an inlet (206, 706) fluidly connected to the intake system. The mixer assembly (204, 603) also includes a mixer (200, 600) having an inlet (208, 702) fluidly connected to the exhaust gas recirculation system (134).  The mixer (200, 600) is at least partially disposed in the intake air conduit (202, 700) and includes an outer pipe (203, 604) and a dividing portion (217, 602) disposed within the outer pipe. The dividing portion (217, 602) divides a first passage (216, 612) from at least one second passage (218, 608), the first passage having an outlet (216', 612') that is at a first height, and the second passage having an outlet ( 218', 608') that is at a second height.
Patent CA-2642207-A1 (CA)
Inventor: OTTENS TIMOTHY
IPC: A01M7/00
Filed: 2007-02-08
Abstract: The present disclosure generally relates to a high throughput system, apparatus, and methods useful for efficiently analyzing experimental liquid formulations applied to plants. In various embodiments, the high throughput system includes a liquid formulation dispensing subsystem (LFDS). The LFDS  includes an automated moveable sample plate platform for holding at least one sample plate. Each sample plate includes a plurality of wells containing plant specimens. The LFDS is operable to sequentially position select ones of the wells at a well target location. Once a selected well is positioned at the target location, a micro-sprayer assembly, including at least one liquid formulation applicator, applies discrete amounts of a liquid formulation to the plant specimens within each selected well.
Patent CA-2644981-A1 (CA)
Inventor: HEEP IRIS
IPC: A61K9/00
Filed: 2007-02-23
Abstract: The invention relates to medicament formulations in liquid form, comprising fluoroquinolones and antioxidant sulphur compounds. The formulations are suitable especially for parenteral applications and feature, inter alia, good compatibility.
Patent CA-2645017-A1 (CA)
Title: Connector to cassette interface system
Inventor: FOSTER JAMES J
IPC: F16L39/00
Filed: 2007-05-24
Abstract: The disclosed connector to cassette interface system includes a set of individual keyed connectors having a shroud on the lower portion. The perimeter of each shroud includes an array of tabs or protrusions keyed to one of a corresponding array of skirted portals in the cassette cover. The tabs or protrusions on the shroud portion of each individual keyed connector may further serve to prevent rotation of each connector beyond about 60°.
Patent CA-2645671-A1 (CA)
Title: Endoscopic apparatus having an improved catheter
Inventor: SURTI VIHAR C
IPC: A61B1/018
Filed: 2007-03-05
Abstract: A delivery apparatus cooperable with a grasping slot of an elevator of endoscope for enhanced delivery to a target location in a patient is disclosed. The apparatus comprises a catheter including an inner lumen and an outer surface. The outer surface has a projection formed thereon. The projection radially extends from the outer surface. The projection is configured to receive the elevator for enhanced delivery in the patient.
Patent CA-2645770-A1 (CA)
Inventor: ALLEN MARK G
IPC: A61B5/00
Filed: 2007-03-14
Abstract: Aspects of the present invention determine the resonant frequency of a sensor by obtain sensor signals in response to three energizing signals, measure the phase of each sensor signal, and using a group phase delay to determine the resonant frequency. The phase difference between the first and second signal is determined as a first group phase delay. The phase difference between the second and third signal is determined as a second group phase delay. The first group phase delay and second group phase delay are compared. Based on the comparison, the system may lock on the resonant frequency of the sensor or adjust a subsequent set of three energizing signals.
Patent CA-2645856-A1 (CA)
Title: Pyrazoles as 11-beta-hsd-1
Inventor: MYERS MICHAEL PAUL
IPC: C07D401/04
Filed: 2007-03-12
Abstract: Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
Patent CA-2647322-A1 (CA)
Title: Two-wire adapter
Inventor: CITTA JAMES W
IPC: H02H9/00
Filed: 2007-04-17
Abstract: A two-wire adapter circuit comprises a current shunt monitor and a circuit for sensing an abrupt change in the output of the current shunt monitor, a power supply, and a two-wire electrical conduit connecting the power supply to a load via the current shunt monitor, the circuit for sensing the abrupt change in the output of the current shunt monitor configured to output a defined digital signal on a third wire upon sensing the abrupt change.