Patent GB-1391802-A (GB)
Title: Derivatives or homologues of cysteamine
IPC: C07C323/25
Filed: 1972-04-21
Abstract: 1391802 Sulphur- and nitrogen-containing compounds L'OREAL 21 April 1972 [23 April 1971] 40043/73 Divided out of 1391801 Heading C2C The following compounds, useful in compositions for counteracting greasy hair and altering the appearance of skin, are claimed as novel, and are prepared by reacting a suitable thiol with an organic halide, an ester of methanesulphonic acid or p-toluenesulphonic acid, a compound with a reactive double bond, an oxirane, an alcohol, ,or ethyleneimine or its acylation or sulphonation derivatives: 1,4- bis - (2 - acetamido - ethylthio) - 2,3 - butanediol, 2 - methylthio - ethylurea, 2 - (2,2 - dimethoxyethylthio) - ethylamine undecylenate, 2- (2,2 - dimethoxy - ethylthio) - ethylamine oxalate, 2- (2,2-dimethoxy-ethylthio)-ethylamine hydrochloride, 2 - (2,2 - diethoxy - ethylthio)- ethylamine acetate, 2-# -ureidoethylthio-ethylamine hydrochloride, 2,2<SP>1</SP>-thio-di(ethylurea), 2 - (dimethylamino - carbonylthio) - ethylamine sulphate, 2 - (butoxycarbonyl - methylthio)- ethylurea, S - # - ureidoethyl thiocarbamate, 2 - p - t - butylphenylthio - ethylamine trichloroacetate, bis - (2 - p - methoxyphenylthioethylamine)tartrate, 2 - tolylthio - ethylamine hydrobromide, 2-(1-biphenylthio)-ethylamine hydrochloride, N - (2 - benzylthio) - ethyl - 6,8- dihydroxy - 7,7 - dimethyl - 5 - oxo - 4 - azaoctanamide, N - (2 - benzylthio - ethyl) - undec- 10 -enamide, N-(2-benzylthio-ethyl)-formamide, N - [2 - (2,6 - dimethyl - phenylthio) - ethyl]- hexanamide, 2-o-aminophenylthio-ethylamine succinate, 4 - (2<SP>1</SP>- benzylthio - ethyl)aminocarbonyl - 2 - amino - butyric acid, 2 - (2- naphthyl - methylthio) - ethylamine hydrochloride, bis - [2 - (2 - naphthyl - thio) - ethylamine]succinate, 2 - o - chlorobenzylthio - ethylamine hydrochloride, 2-y-chlorobenzylthioethylamine glycollate, 2-furfurylthio-ethylamine hydrochloride, 2 - tetrahydrofurfurylthioethylamine p - amino - benzoate, 2 - # - phenylethylthio - ethylamine glutamate, 3 - (2,2- dimethoxy - ethylthio) - propylamine sulphate, 2 - (o - methoxy - benzylthio) - ethylamine hydrochloride, 2 - p - ethoxybenzylthioethylamine hydrochloride, N - [2 - m - fluorobenzylthio - ethyl] - chloroacetamide, 2 - pbromobenzylthio - ethylamine succinate, 2 - (3,4 - dimethoxy - benzylthio) - ethylamine, 2 - (3,4 - methylenedioxy - benzylthio) - ethylamine hydrochloride, 2 - (3,4,5 - trimethoxybenzylthio) - ethylamine hydrocinnamate, 2 - (p - methoxy - benzylthio) - ethylamine salicylate, 2 - o - methylbenzylthio-ethylamine phenylacetate, N - [2 - p - dimethylaminobenzylthio - ethyl] - methanesulphonamide, 2-p-phenoxybenzylthio-ethylamine hydrochloride, 2-#-aminoethylthio-pyridine dihydrochloride, N-[2-benzylthio-ethyl]-2,4- dihydroxy- 3,3-dimethylbutyramide, N-[2-(2- pyridyl - thio) - ethyl] - propionamide, 2- (2 - pyridyl - methylthio) - ethylamine dihydrochloride, #-morpholinoethyl S-(#- acetamidoethyl) - mercaptoacetate, 2-(N- methyl - piperazino) - ethyl S - (# - phenylacetamidoethyl) - mercaptoacetate, #-pyrrolidinoethyl S - (# - ureidoethyl) - mercaptoacetate, # - dimethylaminoethyl S - (# - trifluoroacetamidoethyl) - # - mercaptopropionate, 2 - pnitrobenzylthio - ethylamine crotonate, 2- (# - morpholinocarbonyl - ethylthio)-ethylamine hydrochloride, N,N - di(hydroxyethyl) - S - (#- benzamidoethyl) - mercapto - acetamide, N - [2 - (N<SP>1</SP> - methyl - piperazino - carbonylthio)- ethyl]-acetamide, 2- (1 -naphthyl-thio) -ethylamine hydrochloride, 2 - (2 - p - methoxyphenyl - 2 - propyl - thio) - ethylamine hydrochloride, S - # - ureidoethyl - mercaptoacetic acid, N - (3 - # - ureidoethylthio - propyi)- succinamic acid, 3-allylthio-propyl-ammonium malate, N - (2 - dodecylthio - ethyl) - phenylacetamide, N - (2 - decylthio - ethyl) ptoluenesulphonamide, N - (2 - octadecylthioethyl) - methanesulphonamide, butyl S- (2-amino-ethyl)-mercaptoacetate hydrochloride, N - (2 - benzylthio - ethyl) - picolinamide hydrochloride, N - (2 - benzylthio - ethyl)- isonicotinamide hydrochloride, N - (2 - benzylthio - ethyl) - 2 - methyl - 2 - p - chlorophenoxypropionamide, 2 - benzylthio - ethylurea, and 2-octylthio-etbylamine hydrochloride. The compound NH 2 CONHCH 2 CH 2 SC(NH 2 ) = NH 2  + Bris prepared from thiourea and 2-bromoethylurea.