Patent SG-11201809793U-A (SG)
Title: Tl1a antibodies and uses thereof
Inventor: PASHINE ACHAL
IPC: C07K16/28
Filed: 2017-05-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111 011101011M 0101111 1 0 I 011111011101110110110011110111 OEN Organization (10) International Publication Number International Bureau (43) International Publication Date .....0 WO 2017/196663 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: (74) Agent: PARLET, Nickki L. et al.; Bristol-Myers Squibb CO7K 16/28 (2006.01) A61K 39/00 (2006.01) Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). International Application Number: PCT/US2017/031281 (81) Designated States (unless otherwise indicated, for every International Filing Date: kind of national protection available): AE, AG, AL, AM, 05 May 2017 (05.05.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, Publication Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, Priority Data: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 62/333,470 09 May 2016 (09.05.2016) US PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, Applicant: BRISTOL-MYERS SQUIBB COMPANY TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. [US/US]; Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, Inventors: PASHINE, Achal; c/o Bristol-Myers Squibb GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Company, Route 206 and Province Line Road, Princeton, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, New Jersey 08543 (US). CHEN, Guodong; c/o Bristol-My- ers Squibb Company, Route 206 and Province Line Road, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Princeton, New Jersey 08543 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = = Title: TL1A ANTIBODIES AND Antibody 1500- 1000- LL — 500- 0 (54) USES THEREOF 10A4.F7 Inhibits TL1A binding to hDR3 CHO cells -M- 10A4.F --A- IgG = = = = = = = = -3 : Disclosed are antibodies Methods of making and using the anti-TL1A antibodies are also described. 1 I I 1 -1 0 1 2 Log nM — 1-1 Cr) V; V; cr, ,—, IN N (57) ... TL1A. IC50 0.5254 FIG. 2 that bind specifically to the receptor TNF superfamily member 15 (TNFSF15), also known as [Continued on next page] WO 2017/196663 Al MIDEDIMOMMIDIRMEMOMMEIHRIEHOMOVOIMIE Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of earlier application (Rule 4.17(iii)) the — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))