Patent SG-11201907611W-A (SG)
Title: Influenza vaccines based on aav vectors
Inventor: LIMBERIS MARIA P
IPC: C12N15/86
Filed: 2018-02-27
Abstract: Chickenp CAN actin intron enhancer Rabbit p-globin poly A signal JAba ORF FIG 15 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIP0 I PCT omit VIII °nolo omioollm loon! ono oimIE (10) International Publication Number WO 2018/160573 Al (51) International Patent Classification: C07K 16/10 (2006.01) Cl 2N 15/86 (2006.01) C12N 7/00 (2006.01) (21) International Application Number: PCT/US2018/019974 (22) International Filing Date: 27 February 2018 (27.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/464,753 28 February 2017 (28.02.2017) US 62/504,293 10 May 2017 (10.05.2017) US 62/560,834 20 September 2017 (20.09.2017) US 62/618,443 17 January 2018 (17.01.2018) US (71) Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104 (US). JANSSEN BIOTECH, INC. [US/US]; 800/850 Ridgeview Drive, Horsham, PA 19044 (US). (72) Inventors: LIMBERIS, Maria P.; The Murano, 2101 Market Street, Unit 3805, Philadelphia, PA 19103 (US). TREIAKOVA, Anna P.; 28 Central Street, Woburn, MA 01801 (US). WILSON, James M.; 1831 Delancey Street, Philadelphia, PA 19103 (US). NASO, Michael; 544 Bryn Mawr Ave., Swarthmore, PA 19081 (US). KOLKMAN, Joost; Berkenlaan 7, Maarn 3951 XW (NL). FRIESEN, Robert; Acacialaan 1, Wassenaar 2243 BW (NL). WANG, Qiang; 228 West Winona Street, 1st Floor, Philadelphia, PA 19144 (US). (74) Agent: KODROFF, Cathy A. et al.; Howson & Howson LLP, 350 Sentry Parkway, Building 620, Suite 210, Blue Bell, PA 19422 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: INFLUENZA VACCINES BASED ON AAV VECTORS 1-1 kr) O 1-1 00 1-1 O N O 5' 3' AAV - ITR AAV ITR Chicken beta actin promoter (57) : A non-replicating recombinant adeno-associated associated virus (rAAV) having an AAV capsid having packaged therein a vector genome which comprises AAV inverted terminal repeat sequences and at least one nucleic acid sequence encoding four different immunoglobulin regions (a), (b), (c) and (d) is provided. The rAAV-expressed immunoglobulins are useful for providing passive immunization against influenza A and influenza B. Also described herein are compositions containing the rAAV. Methods of vaccinating patients against influenza are provided.