Patent SG-11201900955V-A (SG)
Title: T cell receptors and immune therapy using the same
Inventor: ALTEN LEONIE
IPC: C07K14/78
Filed: 2017-07-04
Abstract: International Patent Classification: C07K 14/725 (2006.01) C07K 14/78 (2006.01) (21) International Application Number: PCT/EP2017/066630 (22) International Filing Date: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: (26) Publication Language: (30) Priority Data: 10 2016 115 246.3 04 July 2017 (04.07.2017) English English 17 August 2016 (17.08.2016) DE 62/376,059 17 August 2016 (17.08.2016) US 62/376,632 18 August 2016 (18.08.2016) US (71) Applicant: IMMATICS BIOTECHNOLOGIES GMBH [DE/DE]; Paul-Ehrlich-StraBe 15, 72076 Tilbingen (DE). (72) Inventors: ALTEN, Leonie; WeiBdornweg 14, App. 161, 72076 Tilbingen (DE). MAURER, Dominik; Fleinerweg 7, 72116 Moessingen (DE). WALTER, Steffen; 2901 Wrox- ton Road, Houston, Texas 77005 (US). BUNK, Sebastian; Gertrud-Baeumer-Str. 19/1, 72074 Tilbingen (DE). (74) Agent: KRAUSS, Jan B.; BOEHMERT & BOEHMERT, Pettenkoferstrasse 22, 80336 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, O co O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 February 2018 (22.02.2018) WIPO I PCT oimiolollm °nolo olimin °Hula Hum oimIE (10) International Publication Number WO 2018/033291 Al (54) Title: T CELL RECEPTORS AND IMMUNE THERAPY USING THE SAME (57) : The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel T cell receptor (TCR) based molecules which are selective and specific for the tumor expressed antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.