baber/WOPTO huggingface dataset:
Patent JP-2000508328-A (JP)
IPC: A61P43/00
Filed: 1997-04-09
Abstract: PCT No. PCT/EP97/01830 Sec. 371 Date Oct. 6, 1998 Sec. 102(e) Date Oct. 6, 1998 PCT Filed Apr. 9, 1997 PCT Pub. No. WO97/39001 PCT Pub. Date Oct. 23, 1997This invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is zero to 6; p is zero to 3; q is zero to 3; r is zero to 3; R1 and R2 each independently are hydrogen; optionally substituted C1-6alkyl; C1-6alkylcarbonyl; trihalomethylcarbonyl; or R1 and R2 taken together with the nitrogen atom to which they are attached may form a morpholinyl ring or an optionally substituted heterocycle; each R3 and R4 independently are halo, cyano, hydroxy, trihalomethyl, trihalomethoxy, carboxyl, nitro, amino, mono- or di(C1-6alkyl)amino, C1-6alkylcarbonylamino, aminosulfonyl, mono- or di(C1-6alkyl)-aminosulfonyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylcarbonyl or C1-6alkyloxycarbonyl; each R5 independently is C1-6alkyl, cyano or trihalomethyl; X is CR6R7, NR8, O, S, S(=O) or S(=O)2; each independently represents a bivalent aromatic heterocycle wherein the heterocycle may be selected from the group consisting of pyrrole, pyrrazole, imidazole, triazole, furane, thiophene, isoxazole, oxazole, isothiazole, thiazole, pyridine, pyridazine, pyrimidine, pyrazine and triazine; or one of the two bivalent aromatic heterocycles in the compounds of formula (I) may be 1,2-benzenediyl; and aryl is optionally substituted phenyl; it further relates to compositions comprising thesae compounds, as well as their use as therapeutic agents in the treatment or the prevention of CNS disorders, cardiovascular disorders or gastrointestinal disorders.
Patent JP-2001508669-A (JP)
Title: 人工心肺装置における脈動流発生
IPC: A61M60/446
Filed: 1997-03-31
Abstract: (57)【要約】
人工心肺装置の脈動する血液流は、血液をブラダー内に一定の流量で圧送し、ブラダーそれ自体の弾性、又は人間の心拍をシミュレートするようにプログラムできる機械式圧縮機構のいずれかによって人工心肺装置の動脈ライン内にブラダーの内容物を全て周期的に送ることによって行われる。
Patent JP-2000510238-A (JP)
Title: 距離測定器具と物標との距離を測定するための方法および装置
IPC: G01S13/931
Filed: 1997-04-25
Abstract: (57)【要約】
測定器具（１）は、測定器具（１）に対する前述の物標の距離の粗測定値ｄ(ｉ)と相対速度の粗測定値ｖ(ｉ)を同時に提供する。本発明に基づき、前述の速度測定値ｖ(ｉ)を予め定められたずらし時間間隔で積分し、距離の粗測定値ｄ(ｉ)と速度の積分値ｄ'(ｉ)との差を形成し、前述の時間間隔で前述の差の平均値（Ｃ dif ）を計算し、計算された平均値（Ｃ opt ）を速度の積分値ｄ’(ｉ)に加えて、物標と測定器具と間の距離のフィルタリングされた測定値（ｄ filt ）を形成する。
Patent JP-2001516264-A (JP)
Title: 抗生物質含有骨用セメントペースト
IPC: A61L24/00
Filed: 1998-03-17
Abstract: (57)【要約】
本発明は、リン酸カルシウムを含有する生体吸収性ヒドロキシアパタイト類似化合物からなる基礎材料を含有する注入可能であり、また硬化性である骨用セメントペーストに関する。この骨用セメントペーストはまた、塩形態、特に硫酸塩形態のカチオン性抗生物質を含有する。本発明はまた、硬化した生体分解性骨用セメントに関し、この骨用セメントは、貯蔵体形式の効果をもって、生物学的有効濃度で長期間にわたり、抗生物質を放出することができる。本発明による骨用セメントは、骨および骨髄の感染性炎症、特に骨欠損および骨折から生じる感染性炎症の処置に適している。
Patent JP-2001521518-A (JP)
Title: 歯科用プライマー組成物
IPC: A61K6/00
Filed: 1997-11-05
Abstract: (57)【要約】
多部分歯科用接着プライマー組成物は、少なくとも２種の部分Ａおよび部分Ｂで提供される。部分Ａは、酸性重合性化合物と重合性希釈剤とを含む。この部分は、水が存在する場合、部分ＡのｐＨが約２より高くなるように選択される。部分Ｂは、そのｐＨが約２未満になるように酸性材料を含む。基体を接着する方法も記載されている。
Patent JP-2002502578-A (JP)
IPC: H01L41/12
Filed: 1998-05-11
Abstract: A high power ultrasonic motor (21). The motor includes a housing (23) having a predetermined geometry and a transducer (41). The transducer has an active element (42) made from a magnetostrictive material and a coil (51) for producing an electromagnetic filed which extends through at least a portion of the active element. The active element is changeable between a first shape when in the absence of the electromagnetic field and a second shape when in the presence of the electromagnetic field. An electrical signal is provided to the coil for producing the electromagnetic field. An acoustic element (96) is connected to the transducer for providing ultrasonic energy to perform work.
Patent MX-154196-A (MX)
Inventor: HERB ARMIN
IPC: F16B13/04
Filed: 1981-05-13
Abstract: An axially elongated fastening element is made up of an anchor bolt and a spreader wedge each having a wedge surface. Initially the two parts are inserted in the unspread condition into a borehole. By providing relative movement in the axial direction between the wedge surfaces, the fastening element is anchored in the borehole. The wedge surfaces are divided into at least two portions each disposed at a different angle relative to the axis of the fastening element. The initial spreading action is effected when the portion of the wedge surfaces having smaller angles slide relative to one another.
Patent NZ-207277-A (NZ)
Title: A storage paste for preparing porcelain dental prostheses
Inventor: PANZERA C
IPC: A61K6/06
Filed: 1984-02-24
Abstract: A storable paste-like material for use in preparing porcelain dental prostheses comprises porcelain powder, water, and a small amount of a finely divided ceramic material that overcomes the dilatance of the mixture of porcelain powder and water.
Patent NZ-212166-A (NZ)
Title: Stamping die with air passages
Inventor: KOPPA D A
IPC: A21C11/10
Filed: 1985-05-22
Abstract: A die (2) is used having a predetermined shape with indentations therein to press the extrudate rope (10) against a support at predetermined locations to form individual elements of predetermined size and shape. A conveyor belt (62) is used to carry the extrudate rope (10) in one direction, and the die is supported such that during the pressing operation the die forward speed matches the extrudate rope forward speed. A supporting table (96) underlies the conveyor belt. The die formed of a non-stick material has a pair of generally spherical indentations (7) for shaping pieces from the extrudate rope. Bore connects fluid chambers to respective indentations, the fluid pressure in each indentation assists seperation of a shaped piece of the extrudate rope from respective indentation.
Patent NZ-236892-A (NZ)
Title: Preparation of n-phosphonomethylglycine using a tungsten or tungsten/molybdenum catalyst
Inventor: FIELDS DONALD LEE
IPC: C07B61/00
Filed: 1991-01-24
Abstract: A process is provided to produce N-phosphonomethylglycine by the oxidation of N-phosphonomethyliminodiacetic acid to form an intermediate N-phosphonomethyliminodiacetic acid-N-oxide with a peroxide in the presence of an effective amount of a catalyst selected from the group consisting of water-soluble tungsten compounds and a mixture of water-soluble tungsten compounds and a water-soluble molybdenum compound to form the intermediate, and thereafter converting the intermediate N-phosphonomethyliminodiacetic acid-N-oxide to N-phosphonomethylglycine.
Patent NZ-244645-A (NZ)
Title: Benzonaphthyridine derivatives and their preparation
Inventor: DAUBIE CHRISTOPHE
IPC: C07D471/04
Filed: 1992-10-07
Abstract: Process for the preparation of benzo[b]naphthyridines of general formula: <IMAGE> in which R is a carboxyl, alkyloxycarbonyl, cyano, carbamoyl, alkylcarbamoyl, benzylcarbamoyl, hydroxyethylcarbamoyl or dialkylaminoethylcarbamoyl radical or a dialkylcarbamoyl radical in which the alkyl parts may optionally form, with the nitrogen atom to which they are attached, a 5- or 6-membered heterocycle optionally containing another heteroatom chosen from oxygen, sulphur or nitrogen and optionally substituted on the nitrogen by an alkyl radical, R' is H, alkyl, fluoroalkyl, carboxyalkyl, (3 to 6 C)cycloalkyl, fluorophenyl, difluorophenyl, alkyloxy or alkylamino, and Hal is halogen, and their salts, where such exist, characterised in that:   1) an amine of general formula: R'-NH-CH2-CH2-R'' in which R'' is alkyloxycarbonyl, cyano, carbamoyl, alkylcarbamoyl, benzylcarbamoyl, hydroxyethylcarbamoyl, dialkylaminoethylcarbamoyl or dialkylcarbamoyl in which the alkyl parts may optionally form, with the nitrogen atom to which they are attached, a 5- or 6-membered heterocycle optionally containing another hetero atom chosen from oxygen, sulphur or nitrogen and optionally substituted on the nitrogen by an alkyl radical, is condensed with a chlorofluoroquinoline of general formula: <IMAGE> in which R1 is an alkyl radical, the alkyl radicals mentioned above have 1 to 4 C and are straight or branched,   2) the fluoroquinoline of general formula: <IMAGE>  in which R1 is defined as above in 1), is cyclised, 3) the 1,2,3,4-tetrahydrobenzo[b][1,8]naphthyridine of general formula: <IMAGE> is oxidised and the ester obtained is then optionally converted to an acid and optionally converted to a salt.
Patent NZ-260104-A (NZ)
Title: Continuous sterilization of a liquid milk based product wherein the product is sterilized by direct injection of steam and then indirectly cooled prior to flash-cooling
Inventor: ARPH OLLE
IPC: A23C3/037
Filed: 1994-03-16
Abstract: A method of sterilizing a liquid milk based product comprises indirect preheating of the product and final heating to a sterilization temperature 140-150 DEG C by direct steam injection. The product is cooled by so called flash-cooling at which steam corresponding to the added amount of steam is evaporated and the product is further cooled by indirect cooling. It is now proposed that the product prior to the flash-cooling is cooled from the sterilization temperature of 140-150 DEG C to a temperature in the range 90-120 DEG C in an indirect, first cooling step after which the product is cooled by flash-cooling to a temperature of 70-85 DEG C. The arrangement for sterilization comprises a balance vessel (1) connected to an indirectly working first heat exchanger (4) for heating of the milk based product. A steam injection nozzle (6) is arranged in a pipeline leading from the heat exchanger (4). After the steam injection nozzle (6) there is a holding section (8) and a vacuum vessel (10) in which the product is cooled by flash-cooling. A further indirectly working heat exchanger (9) for cooling of the product is connected between the holding section (8) and the vacuum vessel (10).
Patent NZ-260441-A (NZ)
Title: Apparatus and method for capturing and retaining a sample of expired breath from an exhaled breath stream
Inventor: MURNICK JANET GEORGE
IPC: A61B5/097
Filed: 1994-05-03
Abstract: A unit to take and retain a sample of exhaled breath comprises a body (22) with an openable closure (50,52) at each end. Exhaled breath is passed through the body with both ends open, then both closures are closed and latched in the closed position. The closures may be mounted on opposite side of the body and be moved towards each other to the closed position. Alternatively, the closures may be rotatably mounted to the body so that rotation of one w.r.t. the other causes rotation and closures of both.
Patent NZ-268668-A (NZ)
Title: Material for medical use comprising a polymer having a polar group and the anticoagulent (antiplatelet) agent cilostazol
Inventor: IGUCHI SEIICHIRO
IPC: A61L33/00
Filed: 1994-07-13
Abstract: A medical material comprising a polymer or copolymer of a polar vinyl derivative and containing an antithrombocytic agent. Since it can release the antithrombocytic agent in an effective concentration for long, it has a high anticoagulant effect and the effect of preventing platelet loss by activating the same.
Patent NZ-272951-A (NZ)
Title: Aqueous polyol and amine composition; two component coating composition comprising a polyisocyanate and the aqueous polyol and amine composition
Inventor: HART RICHARD E
IPC: C08G18/40
Filed: 1995-09-07
Abstract: A substantially solvent free aqueous two-component coating composition dispersion which, when applied to a substrate, cures to a film having properties of adhesion and bonding which are equal to or superior to films obtained from conventional solvent-based two-component polyurethane or epoxy systems. The first component is a combined aqueous polyol phase and an amine phase. The polyol phase a member consisting of an acid containing polyol or a blend of polyols containing an acid containing polyol such that the average hydroxyl functionality of the polyol phase is at least 1.5 and has an acid number of between about 15 and 200. The amine phase is an amine or blend of amines containing active hydrogens reactive with NCO groups such that the average active hydrogen functionality is at least 1.5. The amine phase is present in a quantity sufficient to substantially neutralize the acid containing polyols. The second component is a member selected from the group consisting of an aliphatic polyisocyanate, a cycloaliphatic polyisocyanate and an aromatic polyisocyanate and adducts and mixtures thereof. The ratio between the isocyanate equivalents and the sum of the active hydrogen equivalents of the polyols and amines is at least 0.5:1 and is preferably at least 1.1:1. The preferential reaction of the isocyanate groups with the active hydrogen moieties from the polyols and amines results in both linear and crosslinking polymerization.
Patent NZ-285910-A (NZ)
Title: Thiadiazole derivatives and antipicornaviral medicaments
Inventor: ALDOUS DAVID J
IPC: A61K31/44
Filed: 1995-05-10
Abstract: Compounds of the formula;    <IMAGE>  Formula I  wherein: Thi is thiadiazolyl or substituted thiadiazolyl alkoxy, fluoromethyl, difluoromethyl, trifluoromethyl, 1,1-difluoroethyl, halo, alkyl, cycloalkyl, hydroxyalkyl, or Y is alkylene bridge of 3-9 carbon atoms; R1 and R2 are each independently chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinyl alkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl, or cyano; R3 is a heterocyclyl chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, oxazolyl, thiazolyl, oxadiazolyl, isoxazolyl, isothiazolyl, or substituted heterocyclyl wherein the substitution is with alkyl, alkoxyalkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, furyl, thienyl, or fluoroalkyl; or a pharmaceutically acceptable salt thereof are effective antipicornaviral agents.
Patent NZ-292756-A (NZ)
Title: Cell separation apparatus and method using centrifugation and density mediums
Inventor: VAN VLASSELAER PETER
IPC: C12N5/0789
Filed: 1995-08-31
Abstract: Disclosed are methods for enriching specific cell types from cell mixtures. Included in the methods are the use of precisely defined cell separation media, a cell separation apparatus that includes a constriction defining a lower region and a defined cell separation medium. The constriction prevents mixing between the upper and lower portions of the tube. Also disclosed is a density adjusted cell separation technique used to augment the above methods. In addition, the invention includes specific methods for isolating CD34<+> hematopoietic progenitor cells, nucleated fetal cells, and breast tumor cells. The isolation methods are useful in various diagnostic and therapeutic regimens.
Patent NZ-328799-A (NZ)
Title: Soil erosion control device comprising dried, chopped, fluffed recycled newspaper
Inventor: BAIRD DAVID MARK
IPC: E02D3/12
Filed: 1998-12-18
Abstract: A filter device, to limit soil erosion, includes an inner component 3 of water absorbent, fibrous material consisting of dried, chopped and fluffed recycled newspaper contained within an outer layer 2 of permeable material.  The inner component may further consist of grass seed and fertilizer.  The permeable material of the outer layer may be hessian or sacking.  The upper and lower surfaces of the outer layer may be interconnected at spaced-apart intervals.
Patent NZ-329538-A (NZ)
Title: Modular circuit breaker, trip and switch apparatus in separate housings
Inventor: LEE SANG DON
IPC: H01H73/06
Filed: 1998-01-05
Abstract: A modular circuit breaker has separate housings for the trip apparatus and the switching apparatus.  The trip apparatus casing 50 includes a trip apparatus housing 100, and has an open top.  The open top is covered by cover 200.  The switching apparatus casing 150 includes switch housing 300, and an open top closed by cover 400.  A trip crossbar 302 is mounted in switch housing 300, and can be tripped by bimetal element 103 which protrudes from trip housing 100.  The two housings 100, 300 are assembled within the circuit breaker housing.  This modular construction allows the rating of the circuit breaker to be altered without replacing the entire assembly, by replacing the appropriate module.
Patent NZ-333768-A (NZ)
Title: Substituted triazolo-pyridazine derivatives as ligands for GABA receptors
Inventor: BROUGHTON HOWARD BARFF
IPC: A61P25/22
Filed: 1997-07-17
Abstract: A compound of formula I, or a salt or prodrug thereof: wherein Y represents hydrogen or alkyl; and Z represents alkyl, cycloalkyl, cycloalkenyl, aryl, heterocycloalkyl, heteroaryl or di(Cl 6)alkylamino, any of which groups may be optionally substituted; or Y and Z are taken together with the two intervening carbon atoms to form a ring selected from cycloalkenyl,  bicycloalkenyl, tetrahydropyridinyl, pyridinyl and phenyl, any of which rings may be optionally benzo-fused and/or substituted; R represents cycloalkyl, phenyl, furyl, thienyl or pyridinyl, any of which groups may be optionally substituted; and R represents cyanoalkyl, hydroxyalkyl, cycloalkylalkyl, propargyl, heterocycloalkylcarbonylalkyl, arylalkyl or heteroarylalkyl, any of which groups may be optionally substituted; provided that, when Y and Z are taken together with the two intervening carbon atoms to form an optionally substituted phenyl ring, then R2 is other than hydroxyalkyl. Compounds of formula (I) are useful for the treatment and/or prevention of anxiety and convulsions, with substantially no sedation. A method of screening for non-sedating anxiolytic compounds, which comprises: (1) contacting a panel of test compounds with (a) a stably transfected recombinant cell line expressing the a3 subunit of the human GABAA receptor; and (b) a stably transfected recombinant cell line expressing the al subunit of the human GABAA receptor; (2) measuring the potentiation of the GABA EC20 response elicited by each test compound in each of the stably transfected cell lines (a) and (b), and (3) selecting out those test compounds which elicit at least a 40% potentiation of the GABA EC20 response in the cell line expressing the a3 subunit, and at most a 30% potentiation of the GABA EC2o response in the cell line expressing the a1 subunit.
Patent NZ-334070-A (NZ)
Title: Compact disc housing including an insert sheet having upright portions extending adjacent front and side walls of the housing
Inventor: DOODSON PETER JOHN
IPC: B65D85/57
Filed: 1998-04-16
Abstract: The invention relates to a housing for holding a disc-shaped information carrier. The housing comprises a bottom section (1) having a holding device (7) and further comprises a cover section (3) which is hingeably connected to the bottom sections. The bottom section is box-shaped and has four transparent walls (1a, 1b, 1c). The bottom section contains an insert sheet (11) having four portions (11a, 11b, 11c) which extend adjacent the transparent walls and which may be provided with readable data relating to the information stored in the information carrier.
Patent NZ-335092-A (NZ)
Title: Heterocyclylmethyl-substituted or benzyl-substituted pyrazole derivatives, pharmaceuticals thereof and their use as inhibitors of the breakdown of cyclic guanosine monophosphate (cGMP)
Inventor: STRAUB ALEXANDER
IPC: A61K31/416
Filed: 1997-10-02
Abstract: The 1-heterocyclylmethyl-substituted pyrazole of the formula (I-I) is described, wherein: R1 is an optionally substituted 5-membered aromatic heterocyclic ring having one heteroatom selected from S, N and O; R2 and R3, including the double bond, form a 5-membered aromatic heterocyclic ring having one heteroatom selected from S, N and O, or a phenyl ring, which are optionally substituted; A1 is an optionally substituted 5- or 6- membered aromatic or saturated heterocyclic ring having up to three heteroatoms selected from S, N and O. The 1-heterocyclylmethyl-substituted pyrazole or 1-benzyl-substituted pyrazole of formula (II-I) is also described, wherein: R20 is an optionally substituted 6-membered aromatic heterocyclic ring having up to three nitrogen atoms; R21 and R22, including the double bond, form a 5-membered aromatic heterocyclic ring having one heteroatom selected from S, N and O, or a phenyl ring, which are optionally substituted; A2 represents optionally substituted phenyl or optionally substituted 5- or 6-membered aromatic or saturated heterocyclic ring having up to three heteroatoms selected from S, N and O. The 3-Heterocyclyl-substituted pyrazole derivative of the general formula (III-I) (as well as isomers thereof) is also described, wherein: R42 is an optionally substituted saturated 6-membered heterocyclic ring having up to 2 heteroatoms selected from S, N and O or an optionally substituted 5-membered aromatic or saturated heterocyclic ring having 2-3 heteroatoms selected from S, N and O, which can also be bonded via a nitrogen atom and which are optionally substituted; R43 and R44, including the double bond, form a 5-membered aromatic heterocyclic ring having one heteroatom selected from S, N and O, or a phenyl ring, which are optionally substituted; A3 is a 5- to 6-membered aromatic or saturated heterocyclic ring having up to three heteroatoms selected from S, N and O, or phenyl, which are optionally substituted; with the proviso that R42 is not pyrrolidinyl or piperidinyl. 1-Benzyl-3-(substituted phenyl or heteroaryl)-fused pyrazole derivatives of the formula (IV-I) (as well as isomers thereof) is also described, wherein: R69 is optionally substituted pyrrole, furan, thienyl or phenyl. R70 and R71 form together an optionally substituted pyrrole, furan, thienyl or phenyl ring; A4 is optionally substituted phenyl. The compounds of formulae (I-I), (II-I), (III-I) and (IV-I) are useful for inhibiting the breakdown of cyclic guanosine monophosphate (cGMP).
Patent NZ-501567-A (NZ)
Title: Electro-mechanical electricity consumption meter which enable external attachment of an optical monitoring assembly
Inventor: WADE PAUL
IPC: G01R11/04
Filed: 1998-06-10
Abstract: An electro-mechanical electricity consumption meter (1) of a type having a sealed housing (2) to prevent tamper therewith is described. The meter (1) is adapted to include a rotatable component (11) which is visible through a portion (23) of the sealed housing (2) and whose rate of rotation is related to the rate of consumption of electricity. The component (11) has at least one marking (15) on a surface thereof such that the rate of rotation of the component can be determined using a monitoring assembly (24) located outside the sealed housing (2) without the need to access the interior of the meter (1). The, or each, marking (15) comprises a visually distinctive boundary between two surface areas (15, 16) of the rotatable component in which the boundary is transverse to the direction of movement of the component. In an alternative arrangement, an existing component (11) is adapted to have markings (15) on its surface. In a particularly preferred arrangement the rotating component comprises a part (11) of the magnet suspension arrangement of the rotor assembly (6).