Patent SG-11201907524U-A (SG)
Title: Peptide vaccines
Inventor: LISZIEWICZ JULIANNA
IPC: G01N33/569
Filed: 2018-03-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIPO I PCT 0111111010 0111 °nolo III OH Emmo IH Imio oimIE (10) International Publication Number WO 2018/158455 Al (51) International Patent Classification: G01N 33/569 (2006.01) A61K 38/00 (2006.01) (21) International Application Number: PCT/EP2018/055230 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 17159243.9 17159242.1 1703809.2 02 March 2018 (02.03.2018) English English 03 March 2017 (03.03.2017) EP 03 March 2017 (03.03.2017) EP 09 March 2017 (09.03.2017) GB (71) Applicant: TREOS BIO ZRT. [HU/HU]; Viola utca 2, 8200 Veszprem (HU). (72) Inventors: LISZIEWICZ, Julianna; Szorosi ut 13, 8220 Balatonalmadi (HU). MOLNAR, Levente; Kossuth Lajos u. 20., 2363 Felsopakony (HU). TOKE, Eniko; Kossuth Lajos u. 20., 2363 Felsopakony (HU). TOTH, Jozsef; Ujkut u. 72, 9012 Gyor (HU). LORINCZ, Orsolya; Attila u. 27, fszt/13, 1047 Budapest (HU). CSISZOVSZKI, Zsolt; Bik- szadi u. 12/A, 4/9, 1119 Budapest (HU). SOMOGYI, Es- zter; Borgazda u. 3, 8220 Balatonalmadi (HU). PANTYA, Katalin; Ulloi ut 16/b 2.em. 9/b, 1085 Budapest (HU). MEGYESI, Monika; Tancsics Mihaly u. 63, 3441 Mezok- eresztes (HU). (74) Agent: KIMBLIN, Nicola; 14 South Square, Gray's Jim, London Greater London WC1R 5JJ (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: PEPTIDE VACCINES (57) : The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that fmd use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.