Patent SG-11201805611R-A (SG)
Title: Porcine reproductive and respiratory syndrome vaccine virus
Inventor: FANG YING
IPC: C12N7/00
Filed: 2017-02-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization MD IIIII0110111 11111 010111110 III 0101111101011111111110111111111110111111 International Bureau ... .... ..Yjd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/142798 Al 24 August 2017 (24.08.2017) WI P0 I P CT (51) International Patent Classification: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, A61K 39/12 (2006.01) C12N 7/00 (2006.01) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (21) International Application Number: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, PCT/US2017/017290 RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (22) International Filing Date: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 10 February 2017 (10.02.2017) ZA, ZM, ZW. (25) Filing Language: English (8 4 ) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (30) Priority Data: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 62/296,658 18 February 2016 (18.02.2016) US TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (71) Applicant: ELI LILLY AND COMPANY [US/US]; LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Lilly Corporate Center, Indianapolis, Indiana 46285 (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: FANG, Ying; c/o Eli Lilly and Company, P.O. GW, KM, ML, MR, NE, SN, TD, TG). Box 6288, Indianapolis, Indiana 46206-6288 (US). WU, Declarations under Rule 4.17: Stephen; c/o Eli Lilly and Company, P.O. Box 6288, Indi- - as to applicant's entitlement to apply for and be granted a anapolis, Indiana 46206-6288 (US). patent (Rule 4.17(ii)) (74) Agents: PFLUGH, David L. et al.; Eli Lilly and Com- as to the applicant's entitlement to claim the priority of the pany, P.O. Box 6288, Indianapolis, Indiana 46206-6288 earlier application (Rule 4.17(iii)) (US). Published: Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, — with international search report (Art. 21(3)) (81) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, _ with sequence listing part of description (Rule 5.2(a)) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, Il GC C:r IN N 71' 11 IN 1-1 (54) Title: PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VACCINE VIRUS 0 N (57) : The present invention relates to modified, live Porcine Reproductive and Respiratory Syndrome viruses. Viruses ea.. ) were genetically analyzed and selected based on phylogenetic grouping for modification by repeated passage in tissue culture. The Z 1 .1 ° modified, live viruses were assessed for the ability to provide protective immunity to heterologous viruses. The modified, live vir - uses are useful in vaccines, particularly in vaccines which can treat infection of swine by multiple heterologous viruses.