Patent SG-11201901684X-A (SG)
Title: Anti-dengue virus antibodies, polypeptides containing variant fc regions, and methods of use
Inventor: SAMPEI ZENJIRO
IPC: C07K16/10
Filed: 2017-09-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 011111111111111 001111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/052375 Al 22 March 2018 (22.03.2018) WIP0 I PCT (51) International Patent Classification: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, C07K 16/10 (2006.01) A61P 31/12 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, A61K 39/42 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (21) International Application Number: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, PCT/SG2017/050465 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: 15 September 2017 (15.09.2017) Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) (25) Filing Language: English (26) Publication Language: English Published: — with international search report (Art. 21(3)) (30) Priority Data: — before the expiration of the time limit for amending the 10201607778X 16 September 2016 (16.09.2016) SG claims and to be republished in the event of receipt of (71) Applicants: CHUGAI SEIYAKU KABUSHIKI amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) KAISHA [JP/JP]; 5-1, Ukima 5-chome, Kita-ku, Tokyo 115-8543 (JP). AGENCY FOR SCIENCE, TECHNOL- OGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventors: SAMPEI, Zenjiro; c/o Chugai Pharmabody Research Pte. Ltd., 3 Biopolis Drive, #07-11 to 16 Sy- napse, Singapore 138623 (SG). KOO, Xing'er Christine; c/o Chugai Pharmabody Research Pte Ltd, 3, Biopolis Dri- ve, #07- 11 to 16 Synapse, Singapore 138623 (SG). FINK, Katja; 8A Biomedical Grove, Immunos #04-01, Singapore 138648 (SG). ZUEST, Roland; 8A Biomedical Grove, Im- munos #04-01, Singapore 138648 (SG). Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; (74) P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (84) 1-1 in (54) Title: ANTI-DENGUE VIRUS ANTIBODIES, POLYPEPTIDES CONTAINING VARIANT FC REGIONS, AND METHODS N OF USE M N (57) : The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding in anti- DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include 0 ---. treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making the same. c)1: 1-1 Nucleic acids encoding polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that © include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in N a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially 0 decreased Cl q-binding activity when compared to the parent Fc region.