baber/WOPTO huggingface dataset:
Patent DO-P2000000030-A (DO)
Title: Derivados de eritropoietina
Inventor: BAILON PASCAL SEBASTIAN
IPC: A61K47/48
Filed: 2000-06-28
Abstract: La presente invención s refiere a conjugados de eritropoyetina con poli(etilen G1ico1) comprendiendo una glicoproteína eritropoyetina que presenta al menos un grupo amino libre y que presenta la actividad biológica in vivo que hace que las células de La Médula ósea incrementen la producción de reticulocitos y glóbulos rojos y que es seleccionada del grupo que consiste en eritropoyetina humana y análogos de la misma que tienen la secuencia de la eritropoyetina humana modificada mediante la adición de entre 1 y 6 sitios de glicosilación o mediante una nueva disposición de al menos un sitio de glicosilación; dicha glucopro teína estando covalentemente unida a n grupos de poli (etilenglicol) De la fórmula -CO-(CH2) x-(OCH2CH2) m-OR Con El carbonilo de cada grupo de poli (etilenglicol) formando Un enlace amida con uno de dichos grupos amino; en donde R es alquilo inferior; x es 2 ó 3; m se encuentra entre alre dedor de 450 y alrededor de 900; n se encuentra entre 1 y 3; y n y m son elegidos de forma que el peso molecular del conjugado menos la glucoproteína eritropoyetina se encuen tre entre 20 kilodaltons y 100 kilodaltons.
Patent DO-P2001000250-A (DO)
Inventor: BORA KEENAN MARTIN
IPC: C07D307/91
Filed: 2001-09-20
Abstract: The invention relates to BCAT inhibitor compounds of formula (I) and use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.
Patent DO-P2016000047-A (DO)
Title: Compuestos y composiciones como inhibidores de la mek
Inventor: BOCK MARK GARY
IPC: C07D471/04
Filed: 2016-02-10
Abstract: LA PRESENTE INVENCIÓN SE RELACIONA CON COMPUESTOS DE LA FÓRMULA I: EN LA CUAL N, R1, R2, R3A, R4 Y R5 SE DEFINEN EN EL RESUMEN DE LA INVENCIÓN; CAPAZ DE INHIBIR LA ACTIVIDAD DE MEK. LA INVENCIÓN PROPORCIONA ADEMÁS UN PROCEDIMIENTO PARA LA PREPARACIÓN DE COMPUESTOS DE LA INVENCIÓN, LAS PREPARACIONES FARMACÉUTICAS QUE COMPRENDEN TALES COMPUESTOS Y MÉTODOS DE USO DE TALES COMPUESTOS Y COMPOSICIONES EN EL MANEJO DE ENFERMEDADES HIPERPROLIFERATIVAS SIMILARES AL CÁNCER.
Patent DO-P2018000201-A (DO)
Title: 1,5-dihidro-4h-pirazolo[3,4-d]pirimidin-4-onas y 1,5-dihidro-4h-pirazolo[4,3-c]piridin-4-onas como inhibidores de pde1
Inventor: JAN KEHLER
IPC: C07D487/04
Filed: 2018-09-19
Abstract: La presente invención proporciona 1,5-dihidro-4H-pirazolo[3,4-d]pirimidin-4-onas y 1,5-dihidro-4H-pirazolo[4,3-c]piridin-4-onas de fórmula (I) como inhibidores de PDE1 y su uso como un medicamento, en particular para el tratamiento de trastornos neurodegenerativos y trastornos psiquiátricos.
Patent EC-SP10010607-A (EC)
Title: 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas
Inventor: BAUER SHAWN M
IPC: A61K31/506
Filed: 2010-11-15
Abstract: La presente invención se dirige a compuestos de la Fórmula I-II y tautómeros, sales o estereoisómeros farmacéuticamente aceptables de la misma que son inhibidores de syk y/o JAK quinasas. La presente invención también se dirige a intermediarios usados para realizar dichos compuestos, a la preparación de dicho compuesto, composiciones farmacéuticas que contienen dicho compuesto, métodos de inhibición de syk y/o JAK quinasa, métodos para la inhibición de agregación de plaquetas, y métodos para evitar o tratar una cantidad de enfermedaddes mediadas, al menos en parte, por la actividad syk y/o JAK quinasa, como por ejemplo trombosis y Linfoma no- Hodgkin.
Patent EC-SP13013023-A (EC)
Title: Composiciones y métodos para transferencia de energía mitocondrial de linea germinal autologa
Inventor: TILLY JONATHAN LEE
IPC: H02J3/00
Filed: 2013-11-14
Abstract: Se describen composiciones derivadas de células madre ovogoniales (OSC), tales como mitocondrias con citoplasma libre de núcleo o aisladas, y usos de las composiciones derivadas de OSC en procedimientos que aumentan la fertilidad autóloga.
Patent EE-200100442-A (EE)
Inventor: MOEBUS MAIK
IPC: E04F15/04
Filed: 2000-02-18
Abstract: The panel (1) is connected to a further panel (2) in positive engagement by connecting devices consisting of a lateral groove (3) formed by two rigid flanks, one of which (6) is longer than the other. The longer flank has a recess (7) and the other panel has a lateral tongue (4) with a lug formation (9) on the lower or upper side. The lug formation can secure in the recess. The side of the tongue with the lug formation has an incline (12), so that in the joined state of the two panels there is a space between the incline and the longer rigid flank. The lug formation in the second state reaches to the bottom of the recess.
Patent EE-200200180-A (EE)
Inventor: SELDER MIKKEL
IPC: C11B3/00
Filed: 2000-09-26
Abstract: Processed linseed oil essentially consisting of linolenic, linolic and oleic acids, mainly in the form of triglycerides, its content of free tocoferol being less than about 100 ppm; and a process for the manufacture of linseed oil comprising the following steps: a) heating crude linseed oil to an increased temperature lower than the boiling point of water, b) adding a heated inorganic acid to the oil and mixing the oil, c) separation of precipitated materials, d) adding a heated aqueous solution of alkali to the oil and mixing the oil, e) discharge of the soap formed, and f) rinsing the oil with hot water until a clear rinsing water is obtained.
Patent EE-200300251-A (EE)
Inventor: PIERS PATRICIA ANN
IPC: A61F9/00
Filed: 2001-12-14
Abstract: An intraocular correction lens has at least one aspheric surface which when its aberrations are expressed as a linear combination of polynomial terms, is capable of, in combination with a lens in the capsular bag of an eye, reducing similar such aberration terms obtained in a wavefront having passed the cornea, thereby obtaining an eye sufficiently free from aberrations.
Patent EE-200400108-A (EE)
Inventor: MAGLIONE DOMENICO
IPC: C07K1/20
Filed: 2002-02-05
Abstract: Process for extracting and purifying the recombinant Placental Growth Factor (PLGF) expressed in inducible prokaryotic expression systems comprising the following steps: I) fermentation of the bacterial cells, II) extraction and purification of the inclusion bodies, III) renaturation of the expressed protein, IV) ion-exchange chromatography, V) reverse-phase chromatography.
Patent GB-185902412-A (GB)
IPC: C11B3/00
Filed: 1859-10-21
Abstract: 2412. Maltby, W. Oct. 21. [Provisional protection only.] Purifying oils.-The oil is agitated with liquid ammonia, and the impurities are allowed to deposit. or the oil may be filtered through a salt. A second method consists in boiling the oil with protoxide of lead and allowing to settle. Sulphuric acid, sulphuretted hydrogen, or common salt, may be added to precipitate the lead, or the oil may be washed.
Patent GB-189700427-A (GB)
Title: Improvements in Rotary Pendulum Escapements.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1897-01-06
Granted: 1898-01-06
Abstract: 427. Thompson, W. P., [Bauer, J. C.]. Jan. 6. Escapements for torsion pendulums. Improvements on the invention described in Specification No. 6356, A.D. 1896. The lever h, pivoted at g between the same plates or cocks as the escapewheel a, is connected by a vertical rod h<2> to an arm on the torsion strip of the pendulum. At each oscillation from the position shown in Fig. 4 to that shown in Fig. 3, one escape-wheel tooth a<2> is released by the notched roller b on the pivot pin of the lever, and a pin a' on. the escape-wheel gives an impulse, after which the following tooth stops against the roller. In the return swing, the tooth does not escape but only gets into the notch of the roller ready to escape.
Patent GB-189702747-A (GB)
Title: Screw-propeller with Moveable Blades.
Inventor: TEXIER EMILE
Filed: 1897-02-02
Granted: 1898-02-02
Abstract: 2747. Texier, E. Feb. 2. Screw propellers are furnished with blades a bolted or otherwise secured to projections b upon the boss c. The joint may be plane as shown in Fig. 4, or dovetailed as shown in Fig. 5.
Patent GB-189704399-A (GB)
Title: Improvements in Brick, Tile, Pipe, ans similar Kilns.
Inventor: PITT GEORGE
Filed: 1897-02-18
Granted: 1897-08-21
Abstract: 4399. Pitt, G. Feb. 18. Kilns for burning bricks, tiles, and the like. By means of flues and convenient dampers the heat is taken to, and exhausted from, the respective chambers as required. Fig. 2 shows the kiln in sectional plan, and Fig. 4 the same in transverse sectional elevation on the line a a, Fig. 2. The chambers are fired from the sides, as shown at A, A. The gases pass in a downward direction to the flues B, which they ascend if permitted by the bell valves E with which, in the smoke flue D, each flue is provided. From the smoke flue the gases are directed as desired.
Patent GB-189706516-A (GB)
Title: An Improved Hair Waver.
Inventor: DONALD ALEXANDER
Filed: 1897-03-12
Granted: 1897-04-24
Abstract: 6516. Donald, A. March 12. Hair-curling appliances.-A hair waver or pin with or without knobs on the ends b, which are bent so as to interlock.
Patent GB-189707284-A (GB)
Title: Improvements in Vessels for Containing Liquids.
Inventor: GOLBY FREDERICK WILLIAM
Filed: 1897-03-20
Granted: 1897-05-08
Abstract: 7284. Golby, F. W., [Lochmann, P.]. March 20. Lids and covers. -Vessels for containing liquids such as beer, wine, &c. which are liable to become stale are provided with a hollow dished cover b joined to the vessel a by rubber c. The cover b can be pushed into the vessel a to discharge the contents.
Patent GB-189709718-A (GB)
Title: Improvements in the Manufacture of Heels for Boots and Shoes
Inventor: RICHARDSON HENRY DELANE
Filed: 1897-04-15
Granted: 1898-02-19
Abstract: 9718. Richardson, H. D. April 15. Heels.-To facilitate the cupping of a heel to fit the shoe, a split lift, rand, or welt b is sewn to the first whole lift a, either above as shown in Fig. 3, or below as shown in Fig. 4.
Patent GB-189721107-A (GB)
Title: Improvement in Automatic Car Couplings.
Inventor: YARNELL LEON JOSEPH
Filed: 1897-09-14
Granted: 1897-10-30
Abstract: 21,107. Yarnell, L. J., and Schmidt, J. H. Sept. 14. Couplings, automatic.-The coupling-pin 7 is supported in the draw-head 1 by a ball 12. This ball is pushed back by the entering coupling- link 3, and runs down the inclines 10 to its forward portion as soon as the link 3 is withdrawn.
Patent GB-189721366-A (GB)
Title: An Improved Electric Arc-light Reflector.
Inventor: BOLLES CHARLES MORRIS
Filed: 1897-09-17
Granted: 1898-07-23
Abstract: 21,366. Bolles, C. M. Sept. 17. Lamp shades and reflectors.-An electric arc lamp is provided with a reflecting-shade 1, carried by an annular band 6 and two hinged semicircular plates 7, which fit upon the lower edge of a conical casing 9, and are secured by clasps. A circular opening and slots 4 in the reflector permit it to be passed overthe lamp.
Patent GB-189725706-A (GB)
Title: Improvements in Tyres for Cycle and other Vehicle Wheels.
Inventor: BAYLY JOHN PITT
Filed: 1897-11-05
Granted: 1898-04-09
Abstract: 25,706. Bayly, J. P., [Leitch, A. K.]. Nov. 5. Tyres, elastic other than pneumatic; felloes or rims.-Tyres consist of split tubes of thin steel, aluminium, or other elastic materials, covered with india-rubber, cloth, or the like. Fig. 1 shows a cross-section of a tyre consisting of a pair of tubes g, h having inwardly-bent edges i, i. Fig. 2 shows a tyre in which a single tube is used. The rim is made as described in Specification No. 2424, A.D. 1897
Patent GB-189814699-A (GB)
Title: Improved Locking Apparatus for Cycles.
Inventor: SCHAEFER ERNST
Filed: 1898-07-04
Granted: 1898-08-06
Abstract: 14,699. Schaefer, E., and Klose, P. July 4. Locking-apparatus to prevent theft.-A clip b, secured by a bolt d to one of the fork members, has pivoted to it a tube i containing a bolt l, which is pressed inwards by a spring as shown. A spring k normally presses the tube i downwards so as to lie against the side of the fork. A similar clip a, secured to the other fork member, carries a suitable lock e, having a spring-pressed bolt g, which can be withdrawn by means of a suitable key h. To lock the cycle, the tube i is turned across the wheel and the bolt l is pulled out till its head o springs past the bolt g. A disc n secured to the bolt l closes the opening in the lock case.
Patent GB-189818722-A (GB)
Title: Improvements in Clips for Attaching to Telephone or other Cables when Drawing the same into Pipes or Conduits.
Inventor: BRIEN JOHN GEORGE
Filed: 1898-09-01
Granted: 1899-07-15
Abstract: 18,722. Brien, J. G. Sept. 1. Couplings for cables to be drawn into pipes or conduits. Fig. 3 shows a section of the clip, in which A is a frame, slightly conical on its inner surface, and having extension arms B joined by a crosspiece C. A screw D works through the cross-piece C, and presses by means of a plate E on the ends of the toothed wedges F for gripping the cable. The outer end of the screw D has an eye. The screw may be omitted, and the wedges otherwise caused to grip the cable.
Patent GB-189820213-A (GB)
Title: Improvements in the Construction of Brackets or Supports for Shelves and the like.
Inventor: HENTSCHEL EMIL
Filed: 1898-09-24
Granted: 1899-09-16
Abstract: 20,213. Kentschel, E. Sept. 24. Brackets.-A sheet-metal blank a is slit at b, b<1>, b<2>, and is then bent to form the shelf bracket as shown in Fig. 2, and the tongue C is bent round at e and riveted at d. The outer strips may, however, be bent round and riveted as shown in Fig. 3. Fig. 7 shows a modification in which only one long slit is made in the blank, and Figs. 5 and 6 modifications in which the tongues C are not slit completely off at one end but simply bent to take up the superfluous length.
Patent GB-189824075-A (GB)
Title: Improvements in Pneumatic Tyres.
Inventor: KEMPSHALL ELEAZER
Filed: 1898-11-15
Granted: 1899-10-14
Abstract: 24,075. Kempshall, E. Nov. 15. Tyres, pneumatic &c.-Relates to pneumatic tyres which have spongy-rubber tread-pieces, Specification No. 25,028, A.D. 1898, being referred to. The air tube A of the single-tube tyre, shown in section in Fig. 1, is enclosed in airproof material a<1> such as manilla paper or glazed muslin, and the cover C is similarly lined. The two layers a', b are cemented together, except at the tread, where a layer B of spongy-rubber is interposed. The part a of the inner layer a may be of ordinary fabric. The invention is applicable to tubeless tyres or, as shown in Fig. 4, to double-tube tyres, and the spongy-rubber may act as a rubber tyre in case of puncture of the air tube.
Patent GB-189906145-A (GB)
Title: Improvements in Trees for Boots and Shoes.
Inventor: WHEATLEY WILLIAM HUMPHREY
Filed: 1899-03-21
Granted: 1899-06-10
Abstract: 6145. Wheatley, W. H., [Leadam, L. H.]. March 21. Trees and stretchers.-The toe section A and heel portion B are connected by an adjustable bar C pivoted to the former and having a slot e with inclined notches f, in one of which the pin d, bridging the forked heel portion B, engages. In a modification, the bar C has notches in one of its edges and the part B is attached to this bar by a pivoted strap which straddles it. In a further modification, Fig. 6, the bar C has a slot e<1> for the pin d<1>, and a number of apertures for the reception of a locking-pin g<1>.
Patent GB-189906741-A (GB)
Title: A New or Improved Machine for Cutting or "Clipping" Rags, Waste, and the like.
Inventor: QUARMBY JOHN SYKES
Filed: 1899-03-29
Granted: 1900-02-10
Abstract: 6741. Quarmby, J. S. March 29. Cutting - machines f or rags &c.-The rags, waste, &c. to be cut are fed by a hopper or placed by hand on a travelling apron consisting of blocks m, mounted on endless bands and carrying spikes n. The apron carries the rags under the pressure rollers x to the disc cutters f, of w h i c h a suitable number are mounted side by side. After the cutting operation, the rags are removed from the apron by the clearing-roller o carrying beaters o<1>. Means are provided for applying tension to the apron and for driving the apron, the clearing-roller, and the cutters at suitable speeds.
Patent GB-189906803-A (GB)
Title: Improvements in Winch Gear for Hoists.
Filed: 1899-03-29
Granted: 1900-03-29
Abstract: 6803. Armstrong, Whitworth, & Co., Sir W. G., and Newitt, L. March 29. Winches. -Relates to improvements on the invention described in Specification No. 3314, A.D. 1898. Fig. 1 shows a plan. Free to move longitudinally upon the shaft a<1> of the motor, but turning with it, is an externally-screwed sleeve d with friction bevelwheels b at its ends. By a hand-lever g the sleeve may be moved to bring either of the wheels b into gear with a bevelwheel c, from which the hoist is driven. A nut h upon the sleeve has a projection which slides in a guide in the frame. When this projection strikes an adjusted end stop, the nut is stopped and the sleeve then is screwed endways to put the wheel b automatically out of gear. The shaft of the wheel c may be driven by hand-gear through spur bevelwheels D, B, and A. For belt-driven hoists, a nut on a screwed shaft has a projection which operates the belt shifter.
Patent GB-189908342-A (GB)
Title: A Light Motor Engine to be Worked either by Steam, Petroleum Vapour or other Motor Fluid.
Inventor: CHARDONNET HILAIRE DE
Filed: 1899-04-20
Granted: 1900-03-17
Abstract: 8342. Chardonnet, Count H. de. April 20. Joint-making packing for rotary engines is used in the way indicated in Fig. 10. Segmental bars l are pressed against the shaft c by sinuous springs m. A spring-pressed wedge n secures the contact at the ends of the bars.
Patent GB-189912521-A (GB)
Title: Improved Apparatus for Branding Sheep and Packages.
Inventor: RENNER GEORGE
Filed: 1899-06-15
Granted: 1899-08-05
Abstract: 12,521. Renner, G., and Boyens, W. H. June 15. Marking animals and the like.-A hand appliance for branding sheep and packages such as wool bales &c. consists of a perforated plate n shaped to give the desired mark and supplied with fluid from a reservoir a, which can be filled by the piston b. A slight blow is struck with the appliance to make the mark. Flow of the liquid is controlled by the holes k, m between the reservoir and plate n, and a guard f protects the piston handle.
Patent GB-189918607-A (GB)
Title: Improvements in and relating to Dental Appliance for Taking Impressions of the Gums in the Production of Artificial Teeth.
Inventor: HAY WALTER DICK
Filed: 1899-09-15
Granted: 1900-04-14
Abstract: 18,607. Hay, E., [Executrix of Hay, W. D.]. Sept 15. Moulding artificial teeth. -Mould plates for taking impressions of gums are provided with means for cooling the plastic material. The mould-plate A is formed hollow, as shown, and is adapted to be secured by a suitable spring device C with the openings G, I over tubes D, E connected with a reservoir J containing a cooling- liquid, which is caused to circulate by means of a ball F. A hook on the reservoir enables it to be attached to the dental chair.
Patent GB-189919179-A (GB)
Title: Improvements in or relating to Friction Discs or Wheels.
Inventor: SCHEIBLER FRITZ
Filed: 1899-09-23
Granted: 1900-07-14
Abstract: 19,179. Scheibler, F. Sept. 23. Friction gearing.-Relates to a covering for friction-wheels, which consists of a number of strips or bands of material arranged side by side on the rim, which is slotted to allow the ends of the bands to be passed through and secured on the inside ; the slots are so arranged that the bands break joint. In the Figures, an angle piece is shown for securing the ends of each band ; one end of the band is fixed by screws passing through the long arm of the angle piece into the wheel rim ; the other end of the band is secured to the short arm by a clamping-plate and screws.
Patent GB-189922221-A (GB)
Title: Improvements in Artificial Tooth Crowns.
Inventor: SEELEY LEWIS SWEETMAN
Filed: 1899-11-07
Granted: 1899-12-09
Abstract: 22,221. Seeley, L. S. Nov. 7. Teeth, crowning.-A doubled metal shank B, preferably an angular strip or wire of platinum or platino-iridium, is placed with its ends a in the plastic material of a tooth crown A, and baked therein. The bend b of the shank may be tapered, leaving a space c, and an expansion d may be formed, or the end may be cut to form two prongs, so that the shank conforms to a single or double cavity C in a natural root, and is secured by cement or filling.
Patent GB-189922975-A (GB)
Title: Improved Arrangement for Fixing Wooden Belt-pulleys.
Inventor: BIRKE ERNST
Filed: 1899-11-17
Granted: 1900-01-20
Abstract: 22,975. Birke, E., and Posern, A. Nov. 17. Mounting and securing pulleys on shafls.-A wooden pulley is fixed by means of a pin e fitted in a hole in one of the spokes b and pressed against a flat on the shaft by a plate f, secured by the bolts g.
Patent GB-189923228-A (GB)
Title: Improvements in Photographic Film Roll Holders.
Inventor: BEUTLER WILLY
Filed: 1899-11-21
Granted: 1899-12-30
Abstract: 23,228. Beutler, W. Nov. 21. Roller slides.-Relates to a simplified construction of roller slide, in which the rollers are not detachable from the frame. In the form shown in section in Fig. 3, the covers g and fare curved to fit round the rollers or spools e and d, and are hinged at h and i to give access to the rollers. The shutter c is made of slats. In other forms, the containing-box is square, and sliding doors may be fitted to give access to the rollers.
Patent GB-189923474-A (GB)
Title: Improvements in Apparatus for Preventing or Removing the Deposit of Moisture on Shop Windows and other Cold Surfaces.
Filed: 1899-11-24
Granted: 1900-10-06
Abstract: 23,474. Statter, J. G., and Vapour Preventer (Limited). Nov. 24. Window fittings.-Relates to apparatus for preventing, or removing, the deposit of moisture on shop windows and other cold surfaces. In the arrangement shown in Figs. 1 and 3, air enters a casing through openings c under the window sill B, is heated by a steam pipe F, and passes through apertures d in the floor C, in close proximity to the window panes A. The steam pipe F is surrounded by a tubular casing D, which communicates with the steam pipe by means of siphon tubes F<2>, G, and is fitted with a tube K for carrying off water of condensation. Tubes I, surrounding the dome-shaped siphon tubes G, are perforated at e to allow air to pass into the spaces between the tubes. Lengths of the tubes D, F may be connected in line by right and left handed screw couplings. In a modification shown in Figs. 2 and 9, parallel tubes F are connected by hollow blocks g and screwed bolts M to form a steam coil. The bolts are made with central or external longitudinal steam passages m. In the arrangement shown in Fig. 8, steam is admitted to an elliptical tube D, and air passes through the open vertical tubes I. The elliptical tubes may be stayed by tie-bolts f, and the ends may be made with elliptical flanges, or circular flanges may be formed on cylindrical ends of the tubes. The outer end of the pipe F is contracted, and connected by a siphon bend with an escape pipe for carrying off water of condensation. The pipe K may be formed with a siphon bend, and may lead to a steam trap. The apparatus may be enclosed in a casing of wood or metal coated with asbestos paper &c.