baber/WOPTO huggingface dataset:
Patent SI-2903616-T1 (SI)
Title: Verwendung von masitinib in kombination mit gemcitabin zur behandlung von einer untergruppe der patienten mit bauchspeicheldrusenkrebs
Inventor: MOUSSY ALAIN
IPC: A61P35/00
Filed: 2013-10-04
Abstract: A method for treating patients afflicted with cancer, wherein the patients are treated with a compound including tyrosine kinase inhibitor, mast cell inhibitor or c-Kit inhibitor, in particular masitinib, optionally in combination with at least one antineoplastic agent. The tyrosine kinase inhibitor, mast cell inhibitor or c-Kit inhibitor, and the optional at least one antineoplastic agent, are administered in a dosage regimen that includes a therapeutically effective amount. Also described are methods for predicting therapeutic response to the treatment in a given patient and therefore identification of applicable patient subpopulations based upon these predictor factors; sometimes referred to as biomarkers. One method is based upon the clinical marker of pain intensity. Another method is based upon gene expression predictive biomarkers assessed via RNA expression in peripheral blood cell samples collected prior to treatment with the compound, which is also used for treating patients afflicted with pancreatic cancer.
Patent DE-3782785-T2 (DE)
Inventor: JENSEN LEIF HELTH
IPC: A61K31/445
Filed: 1987-08-07
Granted: 1993-04-01
Abstract: New piperidine compounds having the formula <CHEM>  wherein    at least one of R<3>, R<4>, and R<5> are <CHEM>  and the other independently are H or C1-6-alkyl,   wherein R' is H, C1-8-alkyl, phenyl, thienyl, cyclopropyl, or C1-3-alkoxymethyl; and    R<1> and R<6> independently are H or C1-6-alkyl <CHEM>  and a salt thereof with a pharmaceutically-acceptable acid. The new compounds are useful in improving the cognitive functions of the forebrain and hippocampus of mammals, and are useful in the treatment of Alzheimer's disease.
Patent DE-3850131-T2 (DE)
Inventor: VOJAK BRUCE ARTHUR
IPC: G02B6/122
Filed: 1988-01-28
Granted: 1994-09-22
Abstract: A laser which contains a substantially planar waveguide (61) wherein the waveguide along the direction of light propagation (64) is comprised of varying combinations of high-gain (62) and low-gain regions (63) so that the cumulative gain from one end of the optical cavity to the other varies as a function of position along a line within the plane of said waveguide (61) which is perpendicular to the direction of light propagation (64).
Patent DE-3856478-T2 (DE)
Inventor: KANNO HIDEO
IPC: G09G3/36
Filed: 1988-11-28
Granted: 2001-11-08
Abstract: A display apparatus comprises (a) a display panel having a display picture area formed by scanning electrodes and data electrodes arranged in a matrix; (b) drive means including a first means for driving the scanning electrodes and a second means for driving the data electrodes; and (c) control means for controlling the drive means so as to repeat a partial rewriting scanning drive comprising applying an scanning selection signal to only a part of the scanning electrodes forming the display picture area.
Patent DE-3876566-T2 (DE)
Inventor: ISHIKAWA SHOICHI
IPC: F16H49/00
Filed: 1988-09-20
Granted: 1993-04-22
Abstract: A strain wave gearing 10 comprises two circular splines 11,12 juxtaposed with each other, a flexspline 13 in the circular splines having the same number of teeth as the first circular spline 11, a wave generator 14 for deforming the flexspline into for example an ellipsoid and a motor for rotating the wave generator. In this flat-shaped gearing, each tooth of the flexspline 13 is provided with a convex tooth face and a concave tooth flank. The tooth profile of the first circular spline 11 is given by such a locus curve L that the tooth face of the flexspline plots when the deformed configuration of the flexspline is rotated by the wave generator 14, and the tooth depth GI of the first circular spline 11 is made equal to or larger than the working depth of the flexspline 13. Thus, the teeth of the flexspline engage with those of the first circular spline to give an engagement region of broader extent than hitherto.
Patent SI-0814789-T2 (SI)
Title: Pharmaceutical compositions comprising monoamine oxidase b inhibitors
Inventor: BREWER FRANCESCA MARY
IPC: A61K31/00
Filed: 1996-03-01
Abstract: A fast dispersing solid pharmaceutical composition having a monoamine oxidase B inhibitor as the only active ingredient is disclosed for the treatment of Parkinson's disease. The composition is formulated to promote absorption through the buccal, sublingual, pharyngeal and/or esophageal mucous membranes, such that at least 5% of the active ingredient is absorbed in one minute, as determined by a buccal absorption test.
Patent DE-60012114-T2 (DE)
Inventor: MENTINK LAURENTIUS ANDREAS GER
IPC: B60J7/12
Filed: 2000-11-27
Granted: 2005-09-08
Abstract: A drive assembly for driving a moveable component (2,63,64) of a vehicle (1,60). The component can adopt one or more positions in which the component prevents access to the vehicle or a part of the vehicle. The drive assembly comprises an actuator (30) which is coupled to the component and provides the force for moving the component, and a control unit (45) for actuating the actuator. The drive assembly has an emergency operating mode, in which the actuator can move freely in at least one direction, in such a manner that the actuator allows movement of the component caused by an external force being exerted on the component other than by means of the actuator, preferably by hand. The drive assembly is also provided with theft detection means (34,50) for detecting theft and/or attempted theft of the vehicle and/or of goods which are present in the vehicle. The theft detection means are coupled to the control unit. The drive assembly is designed in such a manner that, if this assembly is in the emergency operating mode and the moveable component is in a position in which the component prevents access to the vehicle or a part of the vehicle, and then the theft detection means detect theft or attempted theft, the emergency operating mode of the drive assembly is cancelled, and that the drive assembly is then moved into a blocking mode, in which the free mobility of the actuator is cancelled and the actuator blocks movement of the component caused by an external force being exerted on the component.   <IMAGE>
Patent DE-60013513-T2 (DE)
Inventor: GIERSCH KLAUS
IPC: A61Q13/00
Filed: 2000-06-21
Granted: 2005-09-15
Abstract: Use of an optical isomer compound(s) as a perfume for the preparation of perfume compositions or perfumed articles giving a natural scent. Use of an optical isomer compound(s) of formula (I) as a perfume for the preparation of perfume compositions or perfumed articles: R1 = (m)ethyl; R2 = ethyl or propyl; and the undulating line indicates an asymmetric carbon at position 2 and can be R or S. Independent claims are included for: (1) a perfume composition of a perfumed article containing compound (I); and (2) compound (I) per se excluding ethyl (S)-2-tert. butoxypropanoate.
Patent DE-60013769-T2 (DE)
Inventor: THARALSON DOUGLAS
IPC: A47D7/04
Filed: 2000-10-26
Granted: 2005-09-29
Abstract: A co-sleeper convertibly adapted for use as a bassinet or changing table comprising: a frame comprising left and right side rails (58,62) and a rear rail (54), said rails being substantially horizontal and supported by a plurality of vertical supports, said left and right side rails forming a top plane, said frame further comprising a plurality of support rails (90,94), said support rails being substantially horizontal and located on a plane lower than said top plane; an upper front rail (50), said front rail being engagable at a height below said top plane or at a height wherein said upper front rail is substantially coplanar with said top plane; an enclosure (14), said enclosure being sized to fit substantially within the frame and comprising an open top (18) and a bottom panel (22), said open top having a perimeter substantially coextensive with said left and right side rails and said rear rail, said enclosure further comprising left, right and rear walls (34,38,30) extending from said perimeter to said bottom panel, said left and right walls each having a first edge joined to said rear wall, and a second edge opposite from said first edges, said enclosure further comprising a front portion (26), said front portion comprising a flap of sufficient length to allow said flap to be engaged to said upper front rail when said upper front rail is engaged to said frame at a height wherein said upper front rail is substantially coplanar with said top plane, said flap further comprising left and right edges having means for selectively joining said left and right edges to said left and right side walls, respectively, along said second edges to allow a front wall of varying height to be formed; wherein said bottom panel of said enclosure rests on said support rails when said enclosure is disposed within said frame, and further wherein said front portion is selectively joined to said left and right walls and to said upper front rail when said upper front rail is engaged to said frame; and a securing strap assembly for securing the co-sleeper to a parental bed. <IMAGE>
Patent DE-60019559-T2 (DE)
Inventor: SUNDHOLM GOERAN
IPC: A62C37/00
Filed: 2000-10-06
Granted: 2006-02-23
Abstract: The invention relates to a sprinkler comprising a holder body (3), at least one nozzle (2), a heat-activated release means (18) and a cover (13) which in a protective position is arranged in front of said nozzle when the sprinkler is in an inactive mode, the sprinkler comprising means (6, 10) for providing a displacement of the cover from the protective position to a free position in which the cover keeps clear of the nozzle so that it can spray extinguishing medium when the sprinkler is in an active mode, the holder body comprising an inlet (5) for incoming extinguishing medium. In order for the sprinkler to be usable in surroundings where it may be heavily exposed to dirt and impurities and in order for it not to start spraying extinguishing medium when being exposed to heat and with the cover (13) is in a protective position, the cover (13) is arranged, in the protective position, to protect the release means (18) but, when displaced, it is arranged to expose the release means and place the sprinkler in a standby mode in which the release means is intact so as to be able to react to heat and achieve a release of the sprinkler and place it in the active mode, and the means for achieving the displacement of the cover (13) comprises a device (6) which is displaceable with respect to the holder body (3) and which is arranged under fluid pressure to exert a force on a locking means (14, 17) in the cover (13) to make the locking means open and consequently displace the cover to said free position.
Patent DE-60026492-T2 (DE)
Inventor: FITZGERALD FERGUS RUPERT
IPC: C09D7/80
Filed: 2000-02-14
Granted: 2006-10-26
Abstract: A coating system for in-situ coating of a surface formed by a plurality of plasterboard sections comprises a dry powder composition which is dispersible in an aqueous applicator medium and provides a very high quality surface finish to which gloss or matt paint may be applied directly without joint photographing or show-through of fasteners. The coating composition may be applied by a spray coating technique or a roller technique. The dry powder composition comprises calcium carbonate and, by weight, relative to calcium carbonate, from 4% to 11% of a polymeric binder, from 0.60% to 1.5% of a thickening agent and from 0.10% to 0.35% of a surfactant.
Patent DE-60029802-T2 (DE)
Inventor: RAMIREZ-VICK E
IPC: C12Q1/68
Filed: 2000-05-15
Granted: 2007-01-18
Abstract: This invention is related to methods for the immobilization of labeled ligands on solid surfaces using soft metal-soft base bonding. The ligand-binding solid surface comprises a soft metal solid support and a heterobifunctional spacer chemi- or physisorbed to said soft metal solid support via soft metal-soft base bonding.
Patent DE-60035985-T2 (DE)
Inventor: CANE MICHAEL ROGER
IPC: G01N21/35
Filed: 2000-06-01
Granted: 2007-12-06
Abstract: Apparatus for monitoring the presence of one or more chromophores in a tissue sample, apparatus comprises a light source for projecting light to illuminate an area of such tissue sample, a photo-receptor for receiving light re-emitted by the illuminated area of tissue, and spectroscopic analyser means for monitoring the remitted light, a comparator having means for comparing variations in the intensity and spectral characteristics of the remitted light with respect to the intensity and spectral characteristics of the projected light at different wavelengths and with a record of the intensity and spectral characteristics of light remitted by a reference sample of such tissue and means for emitting a control signal in response to any such variations.
Patent DE-60106483-T2 (DE)
Inventor: ABROL NISCHAL
IPC: H04L12/28
Filed: 2001-12-04
Granted: 2005-10-20
Abstract: A novel method and apparatus is disclosed for performing seamless handoff of a mobile station (MS) between Radio Access Networks (RANs) that use different types of wireless interfaces. The described embodiments enable an MS to handoff between different RANs without causing routing ambiguity, and without substantial loss of network data. Upon moving from the coverage area of a first RAN using a first wireless interface to the coverage area of a second RAN using a second wireless interface, an MS determines whether routing ambiguity may result from the change of RAN and, based on the determination, triggers a re-registration of its network address. A foreign agent (FA) within a packet data serving node (PDSN) monitors network address re-registrations in order to determine whether multiple RAN-PDSN (R-P) connections are being created for the same MS. Based on this determination, the PDSN terminates redundant R-P network connections resulting from movement of the MS between different RANs.
Patent DE-60106747-T2 (DE)
Inventor: NIYOGI G
IPC: C08L51/06
Filed: 2001-06-08
Granted: 2005-12-22
Abstract: A nanocomposite material comprises a smectite clay having exhangeable cations that has been treated with at least one organic swelling agent, uniformly dispersed in a graft copolymer having a backbone of a porous propylene polymer material, to which is graft polymerized at least one grafting monomer capable of being polymerized by free radicals, wherein the total inorganic content of the composite material is about 0.5% to about 10%, based on the total weight of the composite. The nanocomposite material is made by graft polymerizing at least one liquid monomer capable of being polymerized by free radicals onto a porous propylene polymer material in a non-oxidizing environment in the presence of a smectite clay and an organic free radical polymerization initiator, whereby the chains of polymerized monomer that are formed intercalate the clay and produce a uniform dispersion of clay particles within the particulate propylene polymer material.
Patent DE-60108362-T2 (DE)
Inventor: GREENHILL SILVIU
IPC: B05C17/01
Filed: 2001-02-15
Granted: 2005-06-02
Abstract: A cartridge dispensing gun comprises a pusher mechanism for incrementally displacing a dispensing piston of the cartridge, said pusher mechanism comprising a pusher rod (4) incrementally advanced by actuation of a trigger to tilt and displace a gripper associated with the rod. The gripper is formed by two or more gripper plates (16) mounted in parallel, and each having a passage through which the rod passes. The passage in the gripper plate is bounded at one side of the gripper plate by an arc of part-circular shape to define a part-circular edge which grips the rod when the gripper plate is tilted upon actuation of the trigger and also by a surface which is inclined to the axis of the passage and which contacts the surface of the rod when the gripper plate is tilted to thereby restrict the extent to which the edge can penetrate into the rod and cause damaging scoring of the rod.
Patent DE-60108770-T2 (DE)
Inventor: BOYD M
IPC: A61F2/46
Filed: 2001-09-18
Granted: 2006-01-12
Abstract: This invention relates to arthodesis for stabilizing the spine. More specifically, the present invention is directed to an intervertebral spacer formed of a bone material and to methods of treating patients having spinal deformities. The invention provides a spinal implant assembly comprising bone-derived components. The bone-derived components can be formed into modular units that can be assembled to provide a wide variety of implant configurations. In addition, the bone-derived components can form scaffold that can withstand the shear and impact forces necessary to insert the assembled implant into a disc space between adjacent vertebrae. In preferred forms the implants define an open spacer that serves as a depot for receipt of an osteoconductive material. The ostoegenic material is preferably a moldable filler that can form a molded reinforced implant.
Patent DE-60111861-T2 (DE)
Inventor: FIRTION ERIC
IPC: B60K15/077
Filed: 2001-11-20
Granted: 2006-05-24
Abstract: The invention concerns a motor vehicle fuel tank ( 1 ) comprising a fuel reserve chamber ( 4 ) further comprising a suction device supplied with fuel coming directly from a fuel filter and adapted to suck up fuel in at least a low suction point outside the chamber ( 4 ), and in delivering it into the chamber ( 4 ) at least in a high delivery point, located above the desired minimum level of fuel in the tank ( 4 ) and higher than the low suction point.
Patent DE-60112325-T2 (DE)
Inventor: MUNDLA REDDY
IPC: C07D491/04
Filed: 2001-12-07
Granted: 2006-05-24
Abstract: Process for making a compound having a structure according to Formula (I), the process comprising reacting an organosilicon reagent with a compound having a structure according to Formula (A).
Patent DE-60112969-T2 (DE)
Inventor: KOBAYASHI SUSUMU
IPC: A61L9/20
Filed: 2001-05-16
Granted: 2006-04-27
Abstract: When an ultraviolet pasteurizer is used in a room free of a person, left and right light shield doors are opened to expose ultraviolet lamps outwardly. When an operation switch on a control panel is then turned on, an operation start timer is actuated, and the ultraviolet lamps are then energized to sterilize surrounding surfaces after elapse of 5 minutes. When the ultraviolet pasteurizer is used in a room occupied by a person, the left and right light shield doors are closed to direct the ultraviolet lamps inwardly until all light shield doors are brought into a substantially triangular prism. When the operation switch on the control panel is then turned on, the ultraviolet lamps and a fan are energized to draw external air from an air inlet. The drawn air passes through an inner radiation chamber defined inwardly of the light shield doors that have been combined into the substantially triangular prism. The air is sterilized by ultraviolet radiation emitted from the ultraviolet lamps and discharged from an air outlet. <IMAGE>
Patent DE-60116799-T2 (DE)
Inventor: COTE SIMON
IPC: C08F216/12
Filed: 2001-11-20
Granted: 2006-09-28
Abstract: The present invention fulfils desired specifications generally rarely encountered with existing solid supports such as highly amphiphile behaviour. The solid support described herein is a poly(ethylene or propylene)glycol based polymer that can be useful in solid and liquid phase synthesis, chromatography, scavenging purposes and immobilisation of proteins and reagents. More specifically, the solid support is a cross-linked polyether derived from a cross-linked polyester which is obtained by copolymerization of at least one monomer comprising (a) one-ended polymerizable vinyl or allyl ketone, ester, ether or mixtures thereof with at least one cross-linker having at least two polymerizable terminal end groups, with the exception of epoxy and oxetane end groups, or (b) divinyl benzene. The method for the preparation of the cross-linked polyether is also disclosed.
Patent DE-60206386-T2 (DE)
Inventor: GLASTRA HENDRIK
IPC: C08F2/50
Filed: 2002-07-19
Granted: 2006-06-22
Abstract: Method for the manufacture of a plastic film material suitable for implantation, by providing a pharmaceutically acceptable, flexible plastic carrier material with a layer of a photopolymerizable synthetic resin composition containing a photo-initiator, which is given a tack-reducing component. This component is chosen from polyurethane, an initiator or a mixture thereof. The initiator preferably generates a curing accelerator after activation. The invention also relates to an expandable intravascular stent obtained using this material.
Patent DE-60208003-T2 (DE)
Inventor: GAO XIAOLIANG
IPC: C08F4/642
Filed: 2002-02-11
Granted: 2006-07-27
Abstract: A supported catalyst for olefin polymerization comprises a combination of a sulfated metal oxide support, an aluminoxane and an organometallic complex of a group 4 metal. The sulfated metal oxide may be quickly and conveniently prepared by, for example, contacting the precursor metal oxide with a sulfuric acid. The supported catalyst of this invention is highly active for olefin polymerization in comparison to conventional catalysts which are prepared with non-sulfated supports.
Patent DE-60213758-T2 (DE)
Inventor: BOULIGNY J
IPC: E21B19/06
Filed: 2002-01-24
Granted: 2007-08-09
Abstract: A wellbore tubular handling system and method is provided for operation in holding and lowering tubulars, such as tubing strings, casing strings, pipe strings, and the various components thereof, at a rig site. The handling system utilizes a shock table with a compressible support surface that compressively moves with a selected compression rate in response to the weight of the wellbore tubular string. The shock table preferably has a shock table body mounted below the rig floor and may conveniently replace the rotary table master bushing except for a flange which supports the shock table on the rig floor. A split-sectioned landing spear can be split open to an open position to thereby allow large items such as collars or other string components to pass through the shock table. In a closed position, the landing spear supports, preferably indirectly, an upper collar of the wellbore tubular string to thereby support the weight of the wellbore tubular string and apply the weight to the compressible support surface of the shock table.
Patent DE-60219190-T2 (DE)
Inventor: DE LUCA ENRICO
IPC: H04W4/02
Filed: 2002-11-15
Granted: 2008-01-03
Abstract: The invention relates to a method for distinguishing between LOCATION_REPORT messages to avoid ambiguities. Therefore, a value of an information element of request type is returned by a radio network controller, depending on an intended receiver of the location information. A control node receiving the information element value analyses said value and determines the receiver depending on the result of said analysis. <IMAGE>
Patent DE-60221898-T2 (DE)
Inventor: QUEVEAU GERARD
IPC: E05F15/00
Filed: 2002-12-31
Granted: 2008-05-08
Abstract: A trunk hood designed to be automatically closed in controlled manner and to cover the trunk in closed position, comprises an inner surface. The hood comprises an inner mat integral with the inner surface, at least one deformable linking means for linking the inner mat to the inner surface mobile between a spaced apart position and a close-up position, and at least one contact switch designed to detect a close-up position of the inner mat relative to the inner surface and to interrupt the movement closing the hood.
Patent DE-60222244-T2 (DE)
Inventor: KOCH GUIDO
IPC: C07D319/06
Filed: 2002-01-21
Granted: 2008-05-29
Abstract: The invention relates to a process for the preparation of a substituted alkene of formula (I) wherein R<SUB>1</SUB>, R<SUB>2 </SUB>and R<SUB>3 </SUB>are independently of each other a protecting group for a hydroxy group or hydrogen and R<SUB>4 </SUB>is phenyl which is unsubstituted or mono- or disubstituted by alkoxy, which alkene constitutes an intermediate for the preparation of discodermolide and discodermolide analogues.