Patent AU-2012304276-B2 (AU)
Title: Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use
Inventor: CONNOLLY TERRENCE JOSEPH
IPC: A61K31/4985
Filed: 2012-11-30
Granted: 2015-01-15
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/082344 Al 6 June 2013 (06.06.2013) WI POI PCT (51) International PatentClassification: 255 Old Fann Road, Flemington, NJ 08822 (US). LE A61K 9/0 (2006.01) A61K 31/4985 (2006.0) ONG, William, Wei..Hwa; 342 Edgewood Avenue, West A61K9/20(2006.01) C07D 487/04 (2006.01) field, NJ 07090 (US). MENON, Anil; 1717 Merriam A61K 9/28 (2006.01) A61P 35/00 (2006.01) Drive, Marlinsville, NJ 08836 (US). MIKLOS, Amanda, (21) International Application Number: Nicole; 1325 Adams Street, Unit 604, Hoboken, NJ 07030 PCT/US2012/067172 (US). (22) International Filing Date: (74) Agents: INSOGNA, Anthony, M. et aL; Jones Day, 222 30 November 2012 (30.11 2012) ast 41s Seet, New York, NY 10017-6702 (US). (2$ Filing Language: English (81) Designated States unlesss otherwise indicated, for ever kind ofnational p-otection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, 1B, BG, BH, BN, BR, BW, BY, BZ, CA, CI, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (30) Priority Data: DO, DZ, EC, IG,E. ES, F, GB, GD, G, Gl, GM, GT, 61/566,109 2 December 2011 (02.12.2011) US HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM. KN, KP, 61/647,288 15 May 2012(l50520:2) US KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 61/653,439 31 May 2012(31.05.2012) US ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 61/670,419 11 July 2012 (11.07.202) US NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (71) Applicant: SIGNAL PHARMACEUTICALS, LLC RW, SC, SD SF, SG, SK, SL, SM, ST, SV, SY, TH, TJ, [US/US]; 4550 Towne Centre Court, San Diego, CA TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, 92121 (US). ZM, ZW. (72) loventors: ASSAF, Mahmoud, S.; 1510 Willever Street, (84) Designated States, (unless otherwise indicated, for ewrr Plainfield, NJ 07063 (US). CONNOLLY. Terrence, kind of regional protection available): ARIPO (BW, GH, Joseph; 104 Wawayanda Road, Wanwick, NY 10990 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, JAMES, Angela, Joubert; 42 F. Huston-Taylor Ct., Mor- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, ris Plains, NJ 07950 (US). KLOPFER, Kevin, Joseph; TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, E, ES, F1, FR. GB, GR, HR, HU, IF, IS, IT, LT. LU, LV, [Continued on nextpage/ (54) Title: PHARMACEUTICAL COMPOSITIONS OF 7(6-(2-HYDROXYPROPAN-2-YL,)PYRIDIN-3-Y)-1-((TRANS)4-METHOXYCYC L OHEXYL)-3.4-DITHYDROPYRAZINO [2.3-R]PYRAZIN-2(l H)-ONF. A SOLID FORM THEREOF AND METHODS OF THEIR USE (57) Abstract: Provided herein ar, compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)- I ((tran),S-4.methoxycyclohexyl)-3,4-di hydropyrazio[2,3-b]pyrazin-2( lh)-one, solid fomns, isotopologues and metabolites thereol and methods of their use for the treatment of a OH disease disera, or condition. H 7r en en W O 2013/082344 Al IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Published: SM, TR), OAPI (BF, BJ, CF, C;, CI, CM, GA, GN, GQ, th international search report (Art. 2(3)) GW, ML, MR, NE, SN, TD, TG).