baber/WOPTO huggingface dataset:
Patent JP-2023550415-A (JP)
Title: 組換え安定化ガレクチン９タンパク質を含む、癌の予防または治療用薬学的組成物
IPC: A61K38/17
Filed: 2021-11-11
Abstract: 本発明は、組換え安定化ガレクチン９タンパク質を含む、癌の予防または治療用薬学的組成物に関し、さらに詳しくは、癌細胞を前記組換え安定化ガレクチン９タンパク質で処理したところ、癌細胞の細胞成長を抑制し、細胞死を誘導する効果が示され、前記組換え安定化ガレクチン９タンパク質を癌誘発動物モデルに投与したところ、体重減少などの副作用なしに癌組織のサイズが減少し、生存率を高める効果が示され、抗癌剤と複合、混合または併用して投与すると、相乗的な抗癌活性を示すことが確認された。故に、本発明に係る組換え安定化ガレクチン９タンパク質を有効成分として含む薬学的組成物は、癌の予防または治療の際に有用に用いることができる。【選択図】図５
Patent JP-2023551449-A (JP)
Title: 通気コア、静電放電抑制、または両方を備えたフィルタ装置
IPC: B01D35/30
Filed: 2021-11-16
Abstract: ハウジングと、ハウジング内の内部と、ハウジング内に収容されたカートリッジアセンブリ（あるいは、「フィルタカートリッジ」として知られる）と、ガス状流体をハウジングの内部からハウジングの外部へと放出するのを可能にするか、または静電抑制機構を含む通気孔とを含む、液体フィルタ装置、ならびに関連する方法が記載される。【選択図】図５
Patent JP-2023551292-A (JP)
Title: メチル化されたポリヌクレオチドを富化するための組成物および方法
IPC: C12Q1/6806
Filed: 2021-11-30
Abstract: 第1の部分試料のDNA中の第2のヌクレオベースとは異なるようにDNA中の第1のヌクレオベースに影響を与える手順；試料を少なくとも第1の部分試料および第2の部分試料へと分配するステップであって、第1の部分試料が第2の部分試料とは異なる割合でヌクレオベース改変を有するDNA（例えば無細胞DNA）を含む、ステップを含み；DNAが配列決定されて、第1のヌクレオベースを第2のヌクレオベースから識別する、DNA分析法が、本明細書で提供される。捕捉されたDNAの第1および第2の集団を含む組合せ物であって、第1の集団が第2の集団とは異なる割合でヌクレオベース改変を有するDNAを含むか、またはそれに由来したものであり、第1の集団が変更された塩基対合特異性を有する、DNA中に元々存在する第1のヌクレオベースの形態と変更された塩基対合特異性を有さない第2のヌクレオベースとを含む組合せ物もまた提供される。
Patent JP-2024501971-A (JP)
Title: Ｃａｒ－ｔ活性を調節するための方法及び組成物
IPC: C12N15/12
Filed: 2021-12-23
Abstract: 本明細書では、操作された及び／または低免疫原性幹細胞、それから分化した操作された及び／または低免疫原性細胞、操作された及び／または低免疫原性ＣＡＲ－Ｔ細胞（初代または操作された及び／または低免疫原性幹細胞から分化した）を含む操作された細胞及び／または低免疫原性細胞ならびにそれらの使用及び生成の関連方法が開示される。本明細書では、ＭＨＣクラスＩ及び／またはＭＨＣクラスＩＩヒト白血球抗原及びＴ細胞受容体の低減された発現を示す操作された及び／または低免疫原性細胞が提供される。一部の実施形態では、かかる細胞はまた、１つまたは複数の寛容原性因子、例えば、ＣＤ４７及び１つまたは複数のキメラ抗原受容体（ＣＡＲ）を外因的に発現する。【選択図】図１
Patent JP-2024503387-A (JP)
Title: 様々な種類のがんに対する免疫療法において使用するためのｈｌａによってディスプレイされるペプチド
IPC: C12N15/62
Filed: 2022-01-14
Abstract: 本発明は、（ｉ）配列番号１～配列番号２１６、（ｉｉ）ならびに、ＭＨＣ分子（単数または複数）に結合する、および／またはＴ細胞の前記変異体ペプチドとの交差反応を誘導する性能を維持するその変異体配列からなる群より選択されるアミノ酸配列を含むペプチド、またはその薬学的に許容可能な塩に関する。
Patent JP-2023546540-A (JP)
Title: 不確実システムの確率的モデル予測制御
IPC: G05B13/04
Filed: 2021-08-05
Abstract: 確率的モデル予測コントローラ（ＳＭＰＣ）は、システムの現在の状態と、システムのダイナミクスのパラメータの不確実性の確率分布とを、システムの出力の測定値に基づいて推定し、推定したパラメータの不確実性の確率分布の一次および二次モーメントでパラメータの不確実性をモデル化するシステムのダイナミクスの関数を含むシステムの制御モデルを更新する。ＳＭＰＣは、現在の状態における更新したシステムの制御モデルを予測ホライズンにわたって最適化することにより、システムを制御するための制御入力を求め、システムの状態を変化させるために制御入力に基づいてシステムを制御する。
Patent JP-2023553204-A (JP)
Title: 歯科処置における鎮静のためのクロニジン及びミダゾラムの経口製剤
IPC: A61K31/5517
Filed: 2021-12-06
Abstract: クロニジン、ミダゾラム、及びフェンタニルを含む固体薬物マトリックス製剤中の薬物組成。固体薬物マトリックス中に含まれる薬物の量は、臨床処置に備えて鎮静を誘導するのに十分である。経口投与した場合、薬物成分は経粘膜的通過により吸収される。この固体薬物マトリックス製剤は、小児歯科診療において特に有用であると考えられる。また、臨床処置を実施する前に固体薬物マトリックス製剤を患者に投与することによって患者に鎮静を誘導する方法も開示されている。【選択図】 図１
Patent MX-2007000812-A (MX)
Title: Reverse link power control in an orthogonal system.
Inventor: AGRAWAL AVNEESH
IPC: H04W52/20
Filed: 2005-07-19
Abstract: A closed-loop reverse-link power control algorithm for a frequency hoppingorthogonal frequency division multiple access (FH-OFDMA) system is described.The power control algorithm adjusts the user's transmit power based oneffective carrier-to-interference (C/I) and Received-Power-Over-Thermal(RpOT) measurements. The algorithm is inherently stable and is effective forFH-OFDMA systems with retransmissions.
Patent MX-2007000945-A (MX)
Title: Storage system having a disposable vacuum bag.
Inventor: TILMAN PAUL A
IPC: B65B31/00
Filed: 2005-07-22
Abstract: The present invention provides a storage system having a storage device having at least one polymeric sheet (16) sealed along a portion of its' periphery to provide an opening (18) to a storage space (22); a resealable closure structure (20) adapted to seal the opening (18) to the storage space (22), the resealable closure structure (20) comprising selectively engaging male and female profiles (21) and a caulking composition (99) suitable for at least incidental contact to food items contained within the storage space (22); a vacuum valve assembly (30) disposed on the polymeric sheet (16); a stand-off structure (70) disposed adjacent to the vacuum valve assembly (30); a portable vacuum pump assembly (40) structured to engage the vacuum valve assembly (30); and a liquid separator assembly (90) coupled to the portable vacuum pump assembly (40).
Patent MX-2007002999-A (MX)
Title: Telomelysin-gfp gene-containing recombinant virus.
Inventor: FUJIWARA TOSHIYOSHI
IPC: G01N33/58
Filed: 2005-09-28
Abstract: It is intended to provide a regent for detecting cancer cells or diagnosing cancer. Morespecifically speaking, a reagent for detecting cancer cells containing a recombinantvirus in which a replication cassette having a human telomerase promoter, E1Agene, IRES sequence and E1B gene in this order is integrated into the E1 regionof the virus genome while a labeling cassette having a gene encoding a labeledprotein and a promoter capable of regulating the expression of the gene is integratedinto the E3 region of the virus genome.
Patent MX-2007006312-A (MX)
Title: Arrangements for providing peer-to-peer communications in a public land mobile network.
Inventor: OLSSON ULF
IPC: H04W40/00
Filed: 2005-10-21
Abstract: A node (200) for routing Peer-to-Peer, P2P, communication between subscribers in a public land mobile network, PLMN, adapted to be located as a gateway between the packet switched domain of the PLMN and an external Packet Data Network, PDN, comprising a routing functionality for routing messages between the packet switched domain of the PLMN and the external PDN, connectable to at least a second node, the node(200) wherein it further comprises a terminating functionality (202) for terminating a protocol carrying a request from a sending subscriber for an IP address given a MSISDN identity of a receiving subscriber, and a database (201) comprising the mapping between the IP address and the MSISDN identity of the receiving subscriber.
Patent MX-2007007288-A (MX)
Title: Deacylation of lps in gram negative bacteria.
Inventor: LEY PETER ANDRE VAN DER
IPC: A61K39/00
Filed: 2005-12-16
Abstract: The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysaccharides (LPS) and compositions comprising LPS, which are provided with or treated with a 3-O-deacylase activity according to the invention and which may be used for pharmaceutical and/or veterinary purposes, in particular for the preparation of whole cell or acellular vaccines against pathogenic Gram negatives such as Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
Patent MX-2007007782-A (MX)
Title: Dental illumination device with single or multiple total internal reflectors (tir).
Inventor: WEST JOHN
IPC: A61C3/00
Filed: 2005-12-21
Abstract: The present invention relates generally to a device that attaches to one or more Light Emitting Diode (LED) light source(s) to transmit and distribute light energy simultaneously across the arches of upper and lower teeth for dental tooth whitening and photo initiation of light curing resins while at the same time retaining the benefits of the light source(s) to be used for individual tooth whitening and curing.
Patent MX-2007009431-A (MX)
Title: Seat for public transportation vehicles.
Inventor: CASASAYAS JUAN SINGLA
IPC: B60N2/75
Filed: 2007-08-03
Abstract: It comprises a seat portion (1) where the user seats, a backrest (2), and at least one armrest (3) foldable between a substantially horizontal position and a substantially vertical position by hinge means (4), said at least one armrest (3) describing a curved path directed downwardly in its rotating movement from its substantially horizontal position to its substantially vertical position. It is characterised in that said at least one armrest (3) comprises guiding means (5, 6) of its foldable movement, and locking means (5a, 6a, 9, 10) to prevent its movement in the axial direction (X) of the hinge means (4). It is obtained a good operation of said at least one armrest during its folding movement, and it is also prevented any undesired movement in the rotating axial direction, and therefore it is very comfortable and safe of use.
Patent MX-2007009778-A (MX)
Title: Method and apparatus for providing harmonic inductive power.
Inventor: KAGAN VALERY
IPC: H05B6/06
Filed: 2006-10-31
Abstract: Method and apparatus for providing harmonic inductive power, and more particularly for delivering current pulses providing a desired amount of pulse energy in high frequency harmonics to a load circuit for inductive heating of an article. By controlling the shape and/or frequency of such current pulses, the apparatus and method can be used to enhance the rate, intensity and/or power of inductive heating delivered by the heater coil and/or to enhance the lifetime or reduce the cost and complexity of an inductive heating power supply. Of particular significance, the apparatus and method may be used to significantly increase the power inductively delivered to a ferromagnetic or other inductively heated load, without requiring an increase of current in the heater coil. This enables new heating applications, and in some known applications, decreases the energy consumption or cooling requirements and/or increase the lifetime of the heater coil.
Patent MX-2007009914-A (MX)
Title: Use of estrogen receptor-b selective agonists for radiation-or chemotherapy-induced mucosistis and radiation cystitis.
Inventor: HARRIS HEATHER A
IPC: A61P17/16
Filed: 2006-02-14
Abstract: The present invention provides a method of treating or inhibiting mucositis or radiation cystitis using an ER?? selective ligand. The present invention also provides compositions, including pharmaceutical compositions, containing the ER?? selective ligand and a traditional medicament for mucositis or radiation cystitis.
Patent MX-2007011097-A (MX)
Title: Systems and methods for beamforming and rate control in a multi-input multi-output communication systems.
Inventor: KADOUS TAMER
IPC: H04J99/00
Filed: 2006-03-09
Abstract: Methods and apparatuses are disclosed that determine a type of channel information based upon whether a wireless device is scheduled to receive symbols. In addition, a determination may be as to a number of hop periods to determine the type of channel information. Further, a distance between hop regions may be utilized to determine a type of channel information.
Patent MX-2007011720-A (MX)
Title: New class of ???? t cells activators and use thereof.
Inventor: BELMANT CHRISTIAN
IPC: A61P35/00
Filed: 2006-03-21
Abstract: The present invention relates to a new class of compounds having ???? T cells activating properties referred to herein as angelyl or tiglyl phosphoesters, compositions comprising any of these compounds and methods for regulating an immune response in a subject comprising the step of administering these compounds.
Patent MX-2007015514-A (MX)
Title: Modular closure latch mechanism.
Inventor: GOMEZ GONZALEZ FERMIN
IPC: E05B65/10
Filed: 2006-06-05
Abstract: The invention relates to a modular closure latch mechanism. The inventive mechanism consists of: a mechanism case (1), a latch (2) comprising a bevelled face (8) and a longitudinal face (9) which is parallel to the plane of the door (47), a latch support (3), a latch pivot pin (4), a bolt (5) for preventing the rotation of the latch (2), a rotary lever (6) bearing the anti-rotation bolt (5), a traveller (7) which can slide longitudinally parallel to the plane of the door (47), and traveller-actuation means. According to the invention, the latch (2) is installed in the support (3) using the pivot pin (4). In addition, the latch is equipped with a housing (11) having a semi-circular cross-section, the ends of which extend tangentially, which is parallel to the pivot pin (4) and which is disposed on the rear face (10) thereof at a distance from the plane of the door (47) which is suitably greater than that from the pivot pin (4) and opposite said pin (4).
Patent MX-2008010415-A (MX)
Title: Dry sprinkler assembly.
Inventor: FEENSTRA SHAWN J
IPC: A62C35/00
Filed: 2007-02-14
Abstract: A dry pipe sprinkler assembly is provided including a sprinkler body having a thermally responsive trigger mounted thereto. A housing, including an inlet end and an outlet end is provided with the outlet end being connected to the sprinkler body. A seal member is disposed at the inlet end of the housing, and a load mechanism extends between the thermally responsive element and the seal member. The load mechanism may include a support portion, a passage tube portion, and an outlet orifice portion slidably received within the housing and movable within the housing upon activation of the thermally responsive trigger to allow the seal member to be dislodged from the inlet end of the housing to allow suppressant fluid to flow therethrough. The dry pipe sprinkler assembly allows the use of different outlet orifice members to provide dry pipe sprinkler assemblies having different K factors while utilizing common components for the remaining dry pipe sprinkler assembly.
Patent MX-2008013625-A (MX)
Title: Absorbent articles with refastenable side seams and intuitive disposal feature.
Inventor: POPP ROBERT L
IPC: A61F13/551
Filed: 2007-03-12
Abstract: A disposable absorbent article including a pair of first fasteners, at least a portion of each first fastener being situated inboard from each longitudinal side edge in the first waist region, each first fastener being adapted to engage at least a portion of the inner surface of the second waist region, each first fastener comprising a resilient material. The disposable absorbent article also includes a disposal fastener, at least a portion of the disposal fastener being situated inboard from the longitudinal side edge in the second waist region, the disposal fastener adapted to engage at least a portion of the outer surface, the disposal fastener comprising a resilient material.
Patent MX-2008015954-A (MX)
Title: Substituted 8-[6-amino-3-pyridyl]xanthines.
Inventor: RIEGER JAYSON M
IPC: A61K31/497
Filed: 2007-06-13
Abstract: The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines and pharmaceutical compositions that are selective antagonists of A2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
Patent MX-2008016097-A (MX)
Title: Security wrapper.
Inventor: NILSSON THOMAS
IPC: E05B73/00
Filed: 2007-06-18
Abstract: A security device comprising a retaining member forming an adjustable loop, including a cable; a ratchet member connected to the cable, operable to narrow the loop and to prevent widening of the loop, including a first main part comprising a gear ring extending in a first plane with a saw tooth profile raised from the plane, a second main part, rotatable relative to the first main part, including a latch member biased towards the first plane to engage the gear ring, and a drum for winding up of the cable.
Patent MX-2009001108-A (MX)
Title: Polymeric viscosity modifiers.
Inventor: SCHECHTMAN LEE ARNOLD
IPC: C08F246/00
Filed: 2007-08-02
Abstract: Cross-linked ampholytic polymers that may be used as rheological modifiers, and/or absorbent gelling materials are disclosed. The polymers may be storage stable in aqueous compositions comprising soluble salt, and/or an oxidizer, such as hydrogen peroxide.
Patent MX-2009003583-A (MX)
Title: Compositions and multiplex assays for measuring biological mediators of physiological health.
Inventor: SATYARAJ EBENEZER
IPC: C12Q1/68
Filed: 2007-10-04
Abstract: Multiplex assays are provided including panels of probes for development of multiplex assays capable of simultaneously measuring multiple biologically-relevant proteins using very small quantities of biological samples to rapidly assess the health status of animals, especially companion animals, as well as to formulate nutritional regimens for improving the health status of animals The probes are provided as are methods for using them to assess the health status of animals, as well as their responses to therapeutic or nutritional interventions therein.
Patent MX-2009005361-A (MX)
Title: Neutralizing monoclonal antibodies against the nogo-66 receptor (ngr) and uses thereof.
Inventor: MEZLER MARIO
IPC: A61K39/395
Filed: 2007-11-21
Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
Patent MX-2009005896-A (MX)
Title: Process and apparatus for preparing alkyl esters of methacrylic acid.
Inventor: GROPP UDO
IPC: C07C69/54
Filed: 2007-08-31
Abstract: The subject-matter of the present invention relates to a process for preparing alkyl esters of methacrylic acid and its conversion products, which can be used in a multitude of chemical synthesis processes which can lead to a wide variety of different further-processing products, and to an apparatus for performing this process.
Patent MX-2009006514-A (MX)
Title: Functionalized amine-based corrosion inhibitors for galvanized metal surfaces and method of using same.
Inventor: KIDAMBI SRIKANTH S
IPC: C23C22/00
Filed: 2007-12-14
Abstract: A composition and method for inhibiting white rust formation on galvanized surfaces. The composition includes hydroxyl-substituted monoamines and polyamines, imino derivatives, and hydroxyamine derivatives. The composition may be introduced onto the galvanized surface, especially in an industrial water system, using a variety of different methods or programs including integrating with current programs or developing a new program.
Patent MX-2009006871-A (MX)
Title: Heterocyclic compounds with cxcr3 antagonist activity.
Inventor: SHIH NENG-YANG
IPC: C07D401/14
Filed: 2007-12-20
Abstract: The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1 or Formula 5: [Chemical formulas should be inserted here as they appear on abstract in paper form.] or a pharmaceutically acceptable salt, solvate or ester thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non limiting example(s) include, psoriasis), autoimmune diseases (non limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non limiting example(s) include, allograft rejection, zenograft rejection), infectious diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
Patent MX-2009007579-A (MX)
Title: Double-cone sphincter introducer assembly and integrated valve assembly.
Inventor: BLANCO ERNESTO E
IPC: A61M5/00
Filed: 2007-11-08
Abstract: A seal assembly includes a first seal, a second seal, and a positioning element. The first seal includes at least one longitudinal slot therein. The second seal includes at least one longitudinal slot therein and is positioned coaxially with the first seal. The positioning element is positioned coaxially with the first seal. The at least one longitudinal slot of the first seal is offset from the at least one longitudinal slot of the second seal in a radial direction from a longitudinal axis of the seal assembly. The seal assembly can be integrated with a closing valve. The seal assembly can also be integrated with a capsule.
Patent MX-2009008873-A (MX)
Title: Composition useful for the treatment of type 2 diabetes.
Inventor: GAETANI FRANCO
IPC: A61P3/10
Filed: 2007-11-20
Abstract: It is described the use of L-camitine and/or an alkanoyl L-camitine, or a pharmaceutically acceptable salt thereof, in combination with a statin, for the preparation of a medicament for the treatment of type 2 diabetes.
Patent MX-2009010975-A (MX)
Title: Method for obtaining synthetic turf.
Inventor: NUSCA ROBERTO
IPC: E01C13/08
Filed: 2007-04-12
Abstract: Method for making a synthetic turf comprising laying a turf (1) consisting of a mat (2) on which a plurality of blades (3, 3a, 3b, 3c) of synthetic material is woven. An infill material (18) is obtained using the granular and fibrous part (17) of a loose product based on ground coconut, alone or with addition of other material such as rubber in granules or sand or other loose vegetable material such as cork. The raw material based on coconut, having a heterogeneous granulometry set between about 500 micron and several mm, is obtained loading a loose product based on ground coconut by a hopper on a conveyor belt for being fed in a sieve, for example a rotating screen that separates the powder part from the granular and fibrous part. In particular, the powder part of the raw material, is gathered on a conveyor belt and from here sent to a storage reservoir. The granular and fibrous part of the raw material, which represents the main product of the process, is, instead, sent by a conveyor belt to a storage, reservoir from where it is taken for the process to provide infill material for a synthetic turf.
Patent MX-2009011603-A (MX)
Title: Flotation apparatus with plate containing holes.
Inventor: MENKE LUCAS
IPC: B03D1/24
Filed: 2008-04-02
Abstract: A flotation apparatus (10) for the separation of solid particles from a suspension with formation of a fraction lacking in solid particles and a fraction rich in solid particles comprises a tank with an inlet (14) for the suspension, with an outlet (16) for the fraction lacking in solid particles, with an outlet (18) for the fraction rich in solid particles, and with at least one block of slats (20) composed of multiple overlapping slats (22), wherein the at least one block of slats (20) has a rear side oriented toward the tank wall and a front side arranged on the opposite side of the block of slats (20). On the rear side of the at least one block of slats, a plate (26) is arranged which extends over at least a part of the rear side of the block of slats, wherein the plate has a plurality of openings which facilitate the penetration of liquid through the plate. The sum of the areas of the individual openings (38) in the upper region, relative to the vertical axis, of the plate, per square centimeter of the plate, is greater than the sum of the areas of the individual openings in the lower region of the plate, per square centimeter of the plate.
Patent MX-2009012360-A (MX)
Title: Flow straightening apparatus.
Inventor: PINKERTON ROBERT N
IPC: F03B11/00
Filed: 2008-05-09
Abstract: An apparatus for straightening fluid flow in a conduit or pipeline, such as an irrigation pipeline, resides in an integral assembly of a conical fluid flow displacement member effective to substantially lineralize the velocity profile of fluid flowing through the pipeline and a plurality of circumferentially spaced vanes extending longitudinally and radially of the conical member and effective to mitigate swirl and eccentric velocity profiles in the flowing fluid. The conical member consists simply of a single cone that is centered in the pipeline by the vanes. A bolt extending through the wall of the pipe and threaded into a nut on a vane secures the straightener in the line.
Patent MX-2009012464-A (MX)
Title: Lng regasification and power generation.
Inventor: MAK JOHN
IPC: F01K27/00
Filed: 2008-05-30
Abstract: LNG is regasified with concurrent power production in systems and methods where the refrigeration content of the LNG condenses a low pressure working fluid vapor and in which the combined refrigeration content of the warmed LNG and low pressure working fluid condensate condenses an intermediate pressure working fluid vapor.