baber/WOPTO huggingface dataset:
Patent WO-2018195593-A1 (WO)
Title: Procédé de culture de cellules de fibrose kystique et procédé de criblage basé sur ce dernier et traitement de la fibrose kystique
Inventor: GARRATT LUKE WISELY
IPC: C12N5/10
Filed: 2018-04-24
Abstract: La présente invention concerne des procédés de criblage de cellules de patient atteint de fibrose kystique pour identifier des agents thérapeutiques convenant au traitement de la fibrose kystique et/ou des infections bactériennes associées à la fibrose kystique. En particulier, la présente invention concerne un procédé de culture de cellules provenant d'un patient atteint de fibrose kystique comprenant : (i) la préparation de cellules épithéliales des voies aériennes primaires (pAEC) provenant dudit patient atteint de fibrose kystique ; et (ii) la co-culture desdites pAEC avec une cellule nourricière de fibroblaste exposée à un rayonnement en présence d'un milieu de culture tissulaire et d'au moins un inhibiteur de kinase associé à Rho (ROCK) pour accroître le nombre de pAEC dans la culture. De plus, l'invention concerne une construction d'expression comprenant une séquence nucléique codant pour un polypeptide rapporteur fonctionnellement lié à une séquence d'acides nucléiques codant pour CFTR ou son mutant, qui facilite l'expression de 150 000 copies du CFTR ou du polypeptide CFTR mutant sur la membrane cytoplasmique d'une cellule.
Patent WO-2020014728-A1 (WO)
Title: A detection system for detecting matter and distinguishing specific matter from other matter
Inventor: ALAMEH KAMAL
IPC: G01N21/31
Filed: 2018-11-23
Abstract: The present disclosure provides a detection system for detecting matter and distinguishing specific matter from other matter. The detection system comprises at least one light source arranged to emit one or more light beams having a known wavelength or wavelength range. Further, the detection system comprises at least one optical element configured to direct the one or more light beams onto a plurality of locations within an area of interest including the matter. The detection system also comprises a detector for detecting intensities of the one or more light beams reflected at the plurality of locations within the area of interest including the matter. In addition, the detection system comprises an outcome determination system. The system is arranged to obtain information indicative of at least a portion of a shape of at least some of the matter based on detected light intensities of the one or more light beams reflected at the plurality of locations. The system is also arranged to obtain information indicative of a spectral intensity distribution based on detected light intensities of the one or more light beams reflected at the plurality of locations. The outcome determination system is arranged determine whether the matter is specific matter based on the information indicative of at least a portion of a shape of at least some of the matter and based on the information indicative of a spectral intensity distribution.
Patent AU-2018200047-A1 (AU)
Title: Internal combustion engine system and control method for internal combustion engine
Inventor: HOTTA SHINTARO
IPC: F02M26/00
Filed: 2018-01-03
Abstract: INTERNAL COMBUSTION ENGINE SYSTEM AND CONTROL METHOD FOR INTERNAL COMBUSTION ENGINE An electronic control unit (50) is configured to select a first cam as a driving cam of an intake valve in a first operation range where a target value of an EGR rate is set to a specified EGR rate, and is configured to select a second cam as the driving cam in a second operation range smaller in valve duration and lift amount than the first cam. Accordingly, in most of the operation regions, the first cam is selected, and the second cam is selected only in a high-torque and high speed region. When the second cam is selected in the high-torque and high-speed region, the state where an actual compression ratio is high can be eliminated, and suction efficiency can be decreased. Therefore, decrease in a knocking limit can be suppressed. IZT co 00 I CD 0 < LU ct) LU cf) !e [LIU 0 < Q- F E U) or CD 0 C/) C/) C/) C14 C/) U) LU c- LU LU LU < F- LU C) LU 0 Co < -::t Co F- [If (D = F- < (D CD - U) LU U) ---------------- co 00 CY) CY) U) C/) C/) C/) LU C14 - ---- --- -- - C/) 0 < LU Cl- LU u) LU C-) =) CD = F- U) !e Cy-LUO (DC)f =LUF < LIU 0 < o M= OU-) Lu 0- F- I F- < [If E U) CD 0 LU = p --------------- IZT co 00 C14 C14 C14 C/) C/) C/) zt 0 < - f u) LU C) U) !e [If [If < w bi LU 0 zt 0- FOf U) Of 0 0 LUC C) I ----------------(=) C14 IZT CY) CY) CY) 0 C/) C14 C14 C/) U) LU < LU C-- LU Co LU (n CD >- I . . e Co LU LU < 0 -t Co I F- F- [If zt -t (D Of F-- < Of U) U) I ---- ---- --- ------* co 00 U) C14 co 0 LU C/) C/) cf) 0 < I LU clF- Co Cl. LU 2 U) LU I-) [If zt otf CD >- . =) LD q I . . cf) < CD F- LU o=LUO LU zt LU - F- 0 < F- CD or f; C-> [If Cl (D LU FI O'f (D Lu 0 U) LU F- LU U) LU in CD F- < U) Orf Of 0 C-D 0 C-) - - - - - - - - - - - C)f F- 0 > fl- F C)f C) < LU >
Patent AU-2018201016-A1 (AU)
Title: Raw Sensor Input Encryption For Passcode Entry Security
Inventor: MCCAULEY NATHAN P
IPC: G06F21/30
Filed: 2018-02-12
Abstract: Abstract A method of encrypting sensor input entries for passcode entry security is disclosed. The method in one embodiment includes presenting a passcode entry interface on an electronic device for a user to input a passcode entry. The electronic device then receives an input event, which is indicative of at least part of the passcode entry by the user, from a sensor of the electronic device. The electronic device then encrypts a sensor value of the input event and transmits the encrypted sensor value to an external system over a network to cause the external system to decipher the passcode entry from the encrypted sensor value. CD 0N a .2 -- D LL >C < C) l0 C)) C)C C4'
Patent AU-2018201470-A1 (AU)
Title: Patient-specific instrumentation and method for articular joint repair
Inventor: COUTURE PIERRE
IPC: A61F2/46
Filed: 2018-02-28
Abstract: Patient-specific instrumentation for use when performing articular joint repair is provided. A patient-specific jig is adapted to be positioned over a bone at an articular surface thereof for assisting in preparing the bone surface for reception of a prosthesis. The jig comprises a bone contacting portion adapted to matingly contact a portion of the articular surface of the bone and a cutting slot adapted to receive therein a saw blade for resecting the articular surface of the bone. The cutting slot may be press-fitted into the opening of a cut guide. A patient-specific plate and a patient-specific rotational guide are also provided for guiding a positioning of the prosthesis over the resected surface of the bone. A method for manufacturing the patient-specific jig is further provided.
Patent AU-2018203990-A1 (AU)
Title: A game controller, system and method of gaming
Inventor: BARNES PAUL
IPC: A63F13/00
Filed: 2018-06-06
Abstract: A gaming system is arranged to implement a game which is based on credit received. A portion of the credit 5 received is allocated to a credit accumulator. The gaming system is arranged to play one or more feature games for the portion of credit accumulated.
Patent AU-2018204247-A1 (AU)
Title: Architecture of networks with middleboxes
Inventor: KOPONEN TEEMU
IPC: G06F15/177
Filed: 2018-06-14
Abstract: Some embodiments provide a system for implementing a logical network that includes a set of end machines, a first logical middlebox, and a second logical middlebox connected by a set of logical forwarding elements. The system includes a set of nodes. Each of several nodes includes (i) a virtual machine for implementing an end machine of the logical network, (ii) a managed switching element for implementing the set of logical forwarding elements of the logical network, and (iii) a middlebox element for implementing the first logical middlebox of the logical network. The system includes a physical middlebox appliance for implementing the second logical middlebox.
Patent AU-2018204263-A1 (AU)
Title: Side by side all terrain vehicle
Inventor: KINSMAN ANTHONY J
IPC: B60N2/10
Filed: 2018-06-14
Abstract: A side by side vehicle is disclosed having a vehicle frame having frame tubes extending from a front to a rear. A vehicle seat frame is positioned in a mid portion of the frame, and positions a seat frame at a raised position relative to the frame tubes. A powertrain comprising an engine, transmission and rear wheel suspension is positioned rearward of the vehicle seat frame and is coupled to the vehicle frame. Side by side seats are supported by the seat frame; and one or more storage units are positioned under the side by side seats. The side by side vehicle also has a utility tray carried by the frame above the rear suspension. -17- -CI C> /oa 0) %4 coN (N Lit
Patent AU-2018204313-A1 (AU)
Title: Therapeutic Proteins with Increased Half-Life and Methods of Preparing Same
Inventor: SIEKMANN JUERGEN
IPC: A61K38/55
Filed: 2018-06-15
Abstract: The present disclosure relates to materials and methods of conjugating a water soluble polymer to a therapeutic protein.
Patent AU-2018205058-A1 (AU)
Title: An Improved Power Transmission System and Method using a Conducting Tube
Inventor: WILSON KENNETH B
IPC: G01V3/00
Filed: 2018-07-09
Abstract: AN IMPROVED POWER TRANSMISSION SYSTEM AND METHOD USING A CONDUCTING TUBE Fig. 2 A system and method for improving power transmission is disclosed. Specifically, a system for improving power transmission can comprise a transmission pipe, a first transceiver, and a second transceiver. The transmission pipe can comprise a fluidic pipe anid have a first length. Thbe first transceiver can be connected to a proximal end of the transmission pipe. The second transceiver can be connected to a di stal end of the transmission pipe, and each of said transceiv ers can be configured to commnunicate. by a signal having a wavelength -equal to two times the length of the transmission pipe, divided by an integer greater than or equal to one,
Patent AU-2018232886-A1 (AU)
Title: Pharmaceutical combinations comprising an anti-LY75 antibody
Inventor: BINASCHI MONICA
IPC: C07K16/28
Filed: 2018-03-09
Abstract: The present disclosure relates generally to the fields of immunology and molecular biology. More specifically, provided herein are pharmaceutical combinations comprising (A) antibodies, or antigen-binding portions thereof, directed against LY75, and (B) a second anti-cancer entity; nucleic acids encoding antibody combinations; methods for preparing antibody combinations; and methods for the treatment of diseases, such as cancers mediated by LY75 expression or activity.
Patent AU-2018250464-A1 (AU)
Title: Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers
Inventor: MAHR ANDREA
IPC: C07K14/47
Filed: 2018-10-18
Abstract: Abstract The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immu notherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine composi tions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
Patent AU-2018261890-A1 (AU)
Title: IGF-1R monoclonal antibodies and uses thereof
Inventor: BURAK ERIC STEVEN
IPC: A61P29/00
Filed: 2018-05-04
Abstract: The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof. The present invention is directed to monoclonal antibodies that target the insulin-like growth factor-1 receptor and the radioimmunoconjugates thereof that demonstrate increased potency and enhance the excretion of a chelating moiety, or a metal complex thereof, when conjugated to a therapeutic moiety, a targeting moiety, or a cross-linking group. In another aspect, the invention features a pharmaceutical composition comprising a compound of the invention; and a pharmaceutically acceptable excipient. In another aspect, the invention features a method of radiation treatment planning and/or radiation treatment, the method comprising administering to a subject in need thereof a compound or pharmaceutical composition of the invention.
Patent AU-2018264440-A1 (AU)
Title: Identity authentication method, device and system
Inventor: CHEN LI
IPC: G06Q20/40
Filed: 2018-05-10
Abstract: The present application provides an identity authentication method, device and system, and the identity authentication method may comprise: an interaction end receiving an interaction instruction initiated with respect to a user and acquiring identity information of the user; and the interaction end sending an identity identification request to a service end, wherein the identity identification request comprises the identity information, and the identity identification request is used to instruct the service end to match the identity information with standard identity information of a candidate user corresponding to the interaction end, so as to determine a user account corresponding to the user, in which the user account is used to respond to an interaction operation corresponding to the interaction instruction, and a user in the vicinity of the interaction end is marked as a corresponding candidate user by the service end. The technical solution of the present application can be used to increase the efficiency of user identity identification and identification accuracy and is beneficial in improving interaction efficiency and security.
Patent AU-2018271990-A1 (AU)
Title: Covalent inhibitors of KRAS
Inventor: LI LIANSHENG
IPC: A61P35/00
Filed: 2018-05-24
Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R
Patent AU-2018290634-A1 (AU)
Title: Stem cell-derived skin precursor cell culture medium and preparation method therefor
Inventor: YU JI MIN
IPC: C12N5/071
Filed: 2018-07-02
Abstract: Provided are a method for preparing a stem cell-derived skin precursor cell culture medium, comprising the steps of: culturing stem cells in a differentiation medium containing ascorbic acid and hydrocortisone to differentiate the stem cells into stem cell-derived skin precursor cells; culturing the differentiated, stem cell-derived skin precursor cells in a medium to produce a culture of stem cell-derived skin precursor cells; and recovering the stem cell-derived skin precursor cell culture medium from the a culture of the stem cell-derived skin precursor cells, a stem cell-derived skin precursor cell culture medium prepared by the method, and a method for producing a protein from stem cell-derived skin precursor cells, comprising the preparing method.
Patent AU-2018293446-A1 (AU)
Title: Seal apparatus and methods of use
Inventor: BROWN GARETH EDWARD GEORGE
IPC: F16J15/3292
Filed: 2018-06-28
Abstract: A seal apparatus and method of use is described. The seal apparatus comprises a seal assembly comprising a plurality of elements assembled together to form a ring structure around a longitudinal axis. The ring structure is operable to be moved between an expanded condition and a collapsed condition by movement of the plurality of elements.; The plurality of elements is operable to be moved between the expanded and collapsed conditions by sliding with respect to one another along respective contact surfaces. Each ofthe plurality of elements is a compound element comprising a substrate and at least one seal member disposed on a part ofa surface of the element.
Patent AU-2018309027-A1 (AU)
Title: Systems and methods for real time preparation of a polypeptide sample for analysis with mass spectrometry
Inventor: WU CHAO-HSIANG
IPC: G01N1/34
Filed: 2018-08-01
Abstract: Systems, and methods that facilitate the performance of an assay of a sample substantially in real-time. Thus, the assay can be performed, and the desired result obtained, much more quickly than allowed by conventional systems and methods.
Patent AU-2018348092-A1 (AU)
Title: Single molecule sequencing and unique molecular identifiers to characterize nucleic acid sequences
Inventor: APTE ZACHARY
IPC: C12Q1/6806
Filed: 2018-10-09
Abstract: Embodiments of a method and/or system (e.g., for improved single molecule sequencing, etc.) can include preparing a set of unique molecular identifier (UMI)-based molecules associated with a set of target nucleic acid sequences; facilitating generation of (e.g., generating, etc.) a set of tagged nucleic acid molecules based on the set of UMI-based molecules and a set of nucleic acid molecules corresponding to (e.g., including, etc.) the set of target nucleic acid sequences; and/or facilitating (e.g., performing, etc.) single molecule sequencing with the set of tagged nucleic acid molecules.
Patent AU-2018353549-A1 (AU)
Title: Method and apparatus for loading and implanting a shape memory implant
Inventor: RITZ JOSEPH P
IPC: A61B17/068
Filed: 2018-10-18
Abstract: An implant insertion device is designed for use with a shape memory implant movable between an unconstrained shape and an insertion shape. The implant insertion device maintains the shape memory implant in its insertion shape until the delivery of the shape memory implant into tissue or bone. Upon the release of the shape memory implant from the implant insertion device, the shape memory implant attempts to move from its insertion shape to its unconstrained shape, thereby releasing mechanical energy into the tissue or bone.
Patent AU-2018358904-A1 (AU)
Title: TriFab-contorsbody
Inventor: BRINKMANN ULRICH
IPC: C07K16/00
Filed: 2018-10-30
Abstract: Herein is reported a multispecific antibody comprising two circular fusion polypeptides each of them comprising a VH/VL-pair and thereby a first and a second binding site, whereby a third VH/VL-pair and thereby a third binding site is formed by the associated of the two circular fusion polypeptides.
Patent AU-2018361642-A1 (AU)
Title: Connector for a water system
Inventor: ARMSTRONG RUSSELL WINSTON
IPC: F16K37/00
Filed: 2018-10-24
Abstract: The present invention relates to a connector (100) for a water system. The connector comprises an inlet connector (105), a connector body and an outlet connector (120) arranged in sequence. The connector body is open-sided so as to form a tundish having an open air gap between the inlet and outlet connectors (105, 120), through which water can fall in use. The connector (100) further comprises a sensor for detecting the presence of water within the connector body.
Patent AU-2018373919-A1 (AU)
Title: Frozen confection composition
Inventor: FREEMAN JENNIFER ELIZABETH
IPC: A23G9/44
Filed: 2018-11-26
Abstract: Frozen confection composition comprising from 0 wt% to 5 wt% fat, from 0 wt% to 10 wt% protein, a fat to protein ratio of less than 1:1 and an emulsifier; wherein the fat droplets of the homogenised pre-mix of the frozen confection have an average droplet size d (3,2) of below 0.6 micron, and significantly reduced shrinkage of the product is observed on heat shock testing of the frozen confection product.
Patent AU-2018379801-A1 (AU)
Title: Double poloidal field coils
Inventor: BUXTON PETER
IPC: H01L39/14
Filed: 2018-12-07
Abstract: A poloidal field coil assembly for use in a tokamak. The poloidal field coil assembly comprises inner and outer poloidal field coils and a controller. The inner poloidal field coil is configured for installation inside a toroidal field coil of the tokamak. The outer poloidal field coil is configured for installation outside the toroidal field coil. The controller is configured to cause current to be supplied to the inner and outer poloidal field coils such that the combined magnetic field produced by the inner and outer poloidal field coils has a null at the toroidal field coil.
Patent AU-2018391657-A1 (AU)
Title: Enantiomeric separation of racemic nicotine by addition of an O,O'-disubstituted tartaric acid enantiomer
Inventor: WEBER BEAT
IPC: A61K31/465
Filed: 2018-12-18
Abstract: The present invention relates to a method of separating racemic nicotine of Formula (l-a) as a mixture of the (R)- and (S)-enantiomers into the enantiomerically pure (S)- and (R)-nicotine represented by Formula (l-b) and (l-c), by adding a mixture of the L- and the D-enantiomer of a O,O'-disubstituted tartaric acid, wherein the molar ratio of the L- to the D-enantiomer is from 80:20 to 95:5, and obtaining the (S)-nicotine of formula (l-b), or by adding O,O'-dibenzoyl-D-tartaric acid and obtaining the (R)-nicotine of formula (l-c).
Patent WO-2019153035-A1 (WO)
Title: Sampling device, method and system
Inventor: DELAERE IAN MERVIN
IPC: B01L9/00
Filed: 2019-02-11
Abstract: Disclosed is a sampling device comprising a support and a sampling sheet, for sampling a surface. The sampling device is able to be folded closed to reduce subsequent contamination. The sampling device is associated with a unique identifier which can be uploaded to a website to allow test results conducted by a testing facility on the sampling device to be associated with and sent to a test result recipient. Also disclosed is a system which allows multiple sampling devices to be transported between a user and a testing facility while minimising the likelihood of compromising the samples in transit. The sampling device, method and system disclosed allows for easy and robust sampling of an environment to determine the likelihood that the environment has been exposed to substances such as illicit drugs, chemicals or biological substances that can be harmful to a person living in that environment.
Patent AU-2019200013-A1 (AU)
Title: Multisubstituted aromatic compounds as inhibitors of thrombin
Inventor: SHORT KEVIN MICHAEL
IPC: C07D405/14
Filed: 2019-01-03
Abstract: There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.
Patent AU-2019200381-A1 (AU)
Title: Method and systems for egr control
Inventor: HENRY LUKE MICHAEL
IPC: F02D41/00
Filed: 2019-01-21
Abstract: METHOD AND SYSTEMS FOR EGR CONTROL Various methods and systems are provided for estimating fresh intake air flow. In one example, a system comprises an engine (104) having an intake manifold (115) to receive fresh intake air and an exhaust gas recirculation (EGR) system (160) to supply EGR to the intake manifold (115), where flow of EGR through the EGR system (160) is controlled by one or more exhaust valves (170). The system further includes a controller (180) configured to adjust a position of the one or more exhaust valves (170) based on an estimated fresh intake air flow rate, where during a first set of operating conditions, the fresh intake air flow rate is estimated based on a total gas flow rate into the engine (104) and further based on a current position of the one or more exhaust valves (170), intake manifold pressure, air-fuel ratio, and fuel flow to one or more cylinders of the engine (104).