baber/WOPTO huggingface dataset:
Patent IL-81832-A0 (IL)
Title: Hybrid interferons,their preparation,pharmaceutical compositions containing them and their use for preparing monoclonal antibodies
IPC: C12P21/00
Filed: 1987-03-09
Abstract: The invention relates to novel hybrid interferons comprising part of an  alpha -interferon and part of an omega-interferon, the N-terminal Met- or N-formyl-Met derivatives of these interferons and, if the peptide sequence of the hybrid interferon contains a glycosylation site, the N-glycosylated derivatives of these interferons, their use as medicaments and as intermediates for the immunisation of test animals and the preparation of these interferons, novel monoclonal antibodies and their use for the purification of  alpha - and omega-interferons, the hybrid cell lines secreting them, and the preparation of these hybrid cell lines, a novel purification procedure for  alpha - and omega-interferons with the aid of a novel antibody affinity column containing the abovementioned novel monoclonal antibodies, and the preparation of these antibodies, novel hybrid plasmids for improving the expression of the omega-interferons, and novel intermediate plasmids for preparing the novel plasmids, and their preparation.
Patent IL-91459-A0 (IL)
Title: Oligodendrocyte inhibitory factor
IPC: C07K16/00
Filed: 1989-08-28
Abstract: A novel oligodendrocyte cytotoxic factor, salts, precursors, fragments and homologs thereof and functional derivatives of said factor or of its fragments or homologs, are selectively toxic to the oligodendrocyte lineage. Pharmaceutical compositions comprising them are useful for inducing regeneration of injured nerves of the central nervous system in mammals.
Patent IL-92541-A0 (IL)
Title: Doxorubicin aqueous solutions
IPC: A61K9/00
Filed: 1989-12-04
Abstract: Stable ready-to-use aqueous solutions of doxorubicin are provided containing a physiologically acceptable salt of doxorubicin, sodium acetone bisulfite as the antioxidant, water, and, if required, an amount of a physiologically acceptable acid or base sufficient to adjust the solution pH to within the range of about 2.5 to 6.0. The solutions have an acceptable shelf-life of greater than three years at 4 DEG C.
Patent IL-97682-A0 (IL)
Title: Apparatus for providing enhanced tissue fragmentation and/or hemostasis
IPC: A61B17/22
Filed: 1991-03-26
Abstract: An improved device for delivering RF current to the operating tool of an ultrasonic surgical apparatus which comprises a switch module for selecting said RF current, an electrically conducting metal band connected to the switch module and an electrically conductive O-ring in electrical contact with the metal band and located around the acoustic conecting member of the apparatus.
Patent IL-99181-A0 (IL)
Title: Polymeric phenol terminated diester compositions derived from dicarboxylic acids and processes for the preparation thereof
IPC: C09D167/00
Filed: 1991-08-14
Abstract: The present invention is directed towards a mixture of phenol terminated diesters and an amino crosslinking agent. The diesters are characterized by a structure consisting of   <IMAGE>   <IMAGE>   wherein R is an aliphatic divalent hydrocarbon radical containing 2 to 40 carbon atoms or a mixture of such radicals, provided however that R contains at least about 8 carbon atoms when n is 0 and p is 0, R1 is an aliphatic or cycloaliphatic hydrocarbon radical containing 2 to 40 carbon atoms or a mixture of such radicals, R2 is a aliphatic, aromatic or a mixture of aliphatic and aromatic hydrocarbon radicals having from 2 to 40 carbon atoms, A is divalent aromatic radical selected from the group consisting of phenylene, naphthylene or bis phenylene, p is 0 or 1, n is 0 or an integer ranging from 1 to about 40, provided however, that p is 0 when n is 0 and p is 1 when n is an integer and   <IMAGE>   <IMAGE>   wherein q is an integer ranging from 1 to about 40, n is 0 or an integer ranging from 1 to about 40 and A, R1 and R2 are as defined above.
Patent IL-107354-A0 (IL)
Title: Stable extended release oral dosage composition
IPC: A61K31/135
Filed: 1993-10-21
Abstract: A film-coated extended release oral dosage composition containing the nasal decongestant pseudoephedrine sulfate in a unique polymer matrix core and a film-coating on such core containing the non-sedating antihistamine, loratadine, and use of the said composition for treating patients showing the signs and symptoms associated with upper respiratory diseases and nasal congestion are disclosed.
Patent IL-122119-A0 (IL)
Title: Encapsulated cells producing viral particles
IPC: A61K35/76
Filed: 1996-06-24
Abstract: The present invention relates to encapsulated cells producing viral particles, especially retroviral particles containing the genome of a retroviral vector carrying therapeutic genes, to methods for the preparation of such encapsulated cells, as well as to the use of such encapsulated cells for the delivery of genes, especially therapeutic genes, to target organs/cells.
Patent IL-122291-A0 (IL)
Title: Diazepinoindoles their preparation and use
IPC: A61K31/551
Filed: 1997-03-27
Abstract: Diazepino indoles of formula (I), their racemic and isomeric forms, and their salts are new. A = aryl or nitrogen heteroaryl (both optionally substituted by 1-3 of halo, lower alkyl, haloalkyl, lower alkoxy, cycloalkoxy, amino, lower alkoxy- or alkyl-carbonylamino); B = OR1, NR2R3, NR2aR3a, NHR2', or NHR2''; R1 = H or R4; R2' = C(NH)NH2; R2'' = R4; R2a, R3a = H or lower alkyl; NR2R3 = 5-7 membered saturated heterocycle optionally containing O, N, or S not attached directly to the first N; R4 = CH2COOH, CO(CH2)pCOOH, COA, COCH=CHCOOH, CO(CH2)nCH3, CO(CH2OCH2)pCH2OCH3, CO(CH2OCH2)pCOOH or (CH2)pNR5aR6a or (CH2)pNR5R6; NR5R6 = as NR2R3; R5a, R6a = as R2a, R3a; n = 0-18; and p = 2-4. Also claimed are intermediates of formula (II).
Patent IL-123002-A0 (IL)
Title: 1-Phenyl-2- phenylacetoxy- ethanone derivatives
IPC: A61K31/351
Filed: 1998-01-20
Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
Patent IL-129099-A0 (IL)
Title: Aircraft fuel transfer pump with auxiliary fuel line scavenge pump
IPC: F04D13/12
Filed: 1997-09-23
Abstract: An improved fuel transfer pump is provided for relatively high flow transfer of fuel from one aircraft to another during an inflight refueling procedure, wherein the fuel transfer pump includes a jet-type scavenge pump for evacuating residual fuel from a fuel line or manifold. The scavenge pump comprises a venturi element connected along a recirculation conduit through which a small fuel flow is diverted from the high pressure discharge side of the fuel transfer pump for return to the fuel tank. The recirculation fuel flow induces a vacuum in a suction throat of the venturi element, and this vacuum is coupled by a suction line to evacuate residual fuel from the fuel line or manifold to the fuel tank. A flow baffle is mounted along the recirculation conduit downstream from the venturi element to ensure flooding and priming of the scavenge pump.
Patent IL-143666-A0 (IL)
Title: Prodrug compounds and process for preparation thereof
IPC: A61K31/337
Filed: 1999-12-10
Abstract: The compound of the invention is a prodrug form of a therapeutic agent linked directly or indirectly to an oligopeptide, which in turn, is linked to a stabilizing group. More generally, the present invention may be described as a new prodrug compound of a therapeutic agent, especially prodrugs comprising an antitumor therapeutic agent, displaying improved therapeutic properties relative to the products of the prior art, especially improved therapeutic properties in the treatment of cancerous tumors and/or in the treatment of inflammatory reactions such as rheumatic diseases. Improved therapeutic properties include decreased toxicity and increased efficacy. Particularly desired are prodrugs which display a high specificity of action, a reduced toxicity, an improved stability in the serum and blood, and which do not move into target cells until activated by a target cell associated enzyme. Prodrug compounds of a marker enabling tumors to be characterized (diagnosis, progression of the tumor, assay of the factors secreted by tumor cells, etc.) are also contemplated. The present invention also relates to the pharmaceutical composition comprising the compound according to the invention and optionally a pharmaceutically acceptable adjuvant or vehicle. Further, a method of decreasing toxicity by modifying a therapeutic agent to create a prodrug is disclosed. Several processes for creating a prodrug of the invention are described. Compounds of the invention include the prodrugs, Suc-ssAla-Leu-Ala-Leu-Dox, Suc-ssAla-Leu-Ala-Leu-Dnr, and Glutaryl-ssAla-Leu-Ala-Leu-Dox. Additionally intermediate compounds, important to the process of preparation of the prodrugs of the invention are claimed.
Patent IL-151164-A0 (IL)
Title: Azacyclic compounds for use in the treatment of serotonin related diseases
IPC: A61P9/08
Filed: 2001-03-06
Abstract: Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is administered to a patient in need of such treatment.
Patent IL-154169-A0 (IL)
Title: Packaging of positive-strand rna virus replicon particles
IPC: C12N15/09
Filed: 2001-08-28
Abstract: The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the expression of helper functions by coinfecting re-combinant poxvirus vectors comprising recombinant polynucleotides. Methods for obtaining psRNAV replicon particles using these packaging systems are disclosed. Immunogenic compositions and pharmaceutical formulations are provided that comprise replicon particles of the invention. Methods for generating an immune response or producing a pharmaceutical effect are also provided.
Patent IL-157937-A0 (IL)
Title: D-hydantoinase, nucleic acid encoding the same, expression vectors including said nucleic acid and host cells expressing the same
IPC: C12N1/15
Filed: 2002-04-03
Abstract: The present invention relates to a novel D-hydantoinase from Ochrobactrum anthropi that enantio-selectively hydrolyzes D-hydantoins to their corresponding D-N-carbamoyl-amino acids; nucleic acids that encode for the enzyme; expression vectors including the nucleic acids; and host cells capable of expressing the enzyme.
Patent IL-179950-A0 (IL)
Title: Electroacoustic underwater antenna
IPC: B63G8/39
Filed: 2006-12-10
Abstract: An electroacoustic underwater antenna, particularly a lateral antenna which can be fixed to the outer hull of an underwater craft, comprising a series of hydrophones (13) successively arranged in at least one elongate, closed, oil-filled cavity at a distance from each other. The aim of the invention is to achieve a high degree of reception sensitivity in the low frequency range with a sufficiently small, vertical aperture angle. The inventive device is easy to produce and mount and is characterized by several cavities (14) which are fitted with hydrophones (13) at a parallel distance from each other, arranged in front of a rigid plate (12) at a distance therefrom. The plate (12) and the cavities (14) are formed in a panel-type, acoustically transparent plastic element (11). Several of said plastic elements (11) are arranged close to each other or behind each other.
Patent IL-188437-A0 (IL)
Title: Automatic mobile luminous device
IPC: F21Y101/00
Filed: 2007-12-26
Abstract: An automatic luminous device whose use does not require an external manual switch, which is substituted by another internal automatic switch, which activates the device only when it is placed on a sufficiently dense metal surface, nor does it require a connecting cable to an external power source, which is replaced by a preferably rechargeable battery. It was designed as an emergency light for police vehicles, and as a back-up light and is fitted with a base or casing (1) and a translucent shade (2), which, when coupled together, form a single body. Externally, the base of the casing (1) is fitted with two or more permanent magnets (3) in order to block the said casing (1), when it is placed on a sufficiently dense metal platform (4). Internally, the said casing (1) is fitted with an automatic trigger switch (5), which is solidly connected to a connector (6) by means of a flange (16) which is in turn solidly attached to a pin (7); the said connector (6) is in turn solidly attached by means of conventional wiring to a rechargeable battery (8), an external back-up connector (9), and the charge (10), perfectly insulated from the rest of the elements making up the device by means of any kind of separating element.
Patent IL-222755-A0 (IL)
Title: Methods of dna purification and purified dna
IPC: C12N15/10
Filed: 2012-10-29
Abstract: The present invention provides methods for the purification of plasmid DNA that includes removal of host cell impurities, such as endotoxins, RNA, proteins, and chromosomal DNA, from an aqueous solution containing plasmid DNA and methods for separation and purification of supercoiled plasmid DNA from an aqueous solution containing a mixture of supercoiled and nicked or relaxed plasmid DNA using hydrophobic interaction chromatography supports.
Patent RO-126662-A0 (RO)
Title: Photo-fenton process modified by in-situ generation of fe2catalyst for advanced oxidation of the organic compounds in waste water
Inventor: ORBECI CRISTINA
IPC: C02F1/72
Filed: 2011-01-07
Abstract: The invention relates to a process for the oxidation of hardly-biodegradable organic compounds in waste water. According to the invention, the process consists in generating in situ the catalytic component, in which the Fe2source consists of a cylindrical metallic mesh/sieve made of steel wherefrom, during the process of oxidation with HO, under the action of the UV radiation generated by a mercury lamp, Fe2is released into the reaction medium by the continuous and controlled surface oxidation of the metallic mesh, at a pH value of 2.5...4, leading to an increased organic compound degradation efficiency of more than 80%, in reduced operation time.
Patent RO-126840-A0 (RO)
Title: Frustoconical inertial separator and filtering assembly containing the same
Inventor: BADEA GHEORGHE
IPC: B01D27/00
Filed: 2011-05-02
Abstract: The invention relates to a separator for purifying natural fuel gases and to an assembly containing the same used in the natural gas industry. According to the invention, the separator consists of a conical construction (7) comprising some frustoconical rings (1) which end with a nozzle (5) mounted in a channel (3) concentrical with the construction (7) and a dust accumulator (2). According to the invention, the assembly comprises the frustoconical inertial separator (10) mounted on a conduit (6), in horizontal position, in series with some filters (11 and 12) with filtering cartridges and a meter (13).
Patent RO-131852-A0 (RO)
Title: Calcium-enriched active yeast biomass-based product and process for preparing the same
Inventor: BĂRBULESCU IULIANA DIANA
IPC: C12N1/16
Filed: 2017-01-12
Abstract: The invention relates to a calcium-enriched active yeast biomass-based product used as a food supplement for regulating calcium deficiency and as a bio-ingredient in bakery products, for its sensorial qualities and to a process for preparing the same. According to the invention, the product is based on active yeast biomass with the strain of Candida sp. with the collection number IDA DVPG37P, having an assimilated calcium concentration of 8200...18000 mg/kg and an active yeast dry cellular concentration of 1% by mass. As claimed by the invention, the process consists in isolating the strain from white wine, preparing the maintenance culture, the pre-inoculum culture, inoculum culture of generation 1 and/or 2, followed by inseminating the fermentation medium with inoculum of generation 1 and/or 2, separating the fermented medium, resulting in the wet yeast biomass which is then purified and dried.
Patent RO-137394-A0 (RO)
Title: Roll-over protection system for electric scooters
Inventor: FLORESCU VIRGIL
IPC: B62H1/12
Filed: 2022-12-09
Abstract: The invention relates to a roll-over protection system for electric scooters. According to the invention, the system consists of two longitudinal expandable bars (7) which are integral with a support plate (1) of a scooter, each of the two longitudinal bars (7) fixed under the support plate (1) making a sharp angle with the travel direction, they having inside a shaft (9) which is normally in withdrawn position, the shaft (9) having, at the front end, a support roller (10) which is normally placed above the ground, but which gets into contact with the ground when the shaft (9) reaches the extended position, and at a rear end, the shaft (9) has a triggering system which enables its forward release upon emergency braking, the actuation being performed by a coil spring or an electromechanical actuator, in which case automatic triggering is also possible in impact situations when the user is taken by surprise and does not have time to brake.
Patent RO-137556-A0 (RO)
Title: Assistive system for motorcycles
Inventor: CIŞMAŞ IOANA
IPC: B60R21/0132
Filed: 2023-03-09
Abstract: The invention relates to an assistive system for motorcycles. According to the invention, the system consists of a sensing and communication device (DSC), which is mounted on a motorcycle (1) driven by a motorcyclist (2), of a motorcyclist's body position monitoring device (DMPC), the sensing and communication device (DSC) communicating with a mobile device (3) running a mobile application (4) as well as a server (5) running a server application (6), the communication being established via a communications relay (7), which belongs to a mobile communications network.
Patent AP-2002002569-A0 (AP)
Title: Needle protecting arrangement.
Inventor: OLOVSON GUDMAR
IPC: A61M5/158
Filed: 2000-12-11
Abstract: The invention relates to a needle protection arrangement (2) for a hypodermic syringe (1), with a needle protector (2'). The hypodermic syringe (1) includes a container (10) and plunger (12), inside the container, to which a rod (11) imparts reciprocal motion and a needle (14) affixed to, or fastenable to, one end-part of the container. The needle protector (2) has a sealing membrane (2b) across its tubular cross-section at the opposite end form the container. The needle protector (2') has a first disnct position (100) prior to use and a second distinct and locked position (200) after use.
Patent MA-26988-A1 (MA)
Title: Nouveau sel de la thiazolidinedione et ses varietes polymorphiques en tant qu'agents antidiabetiques et methode pour les obtenir.
Inventor: DEL CASTILLO NIETO JUAN CARLOS
IPC: A61P5/00
Filed: 2003-07-31
Abstract: La présente invention se rapporte à un nouveau sel de la thiazolidinedione et ses variétés polymorphiques qui ont une grande activité hypoglycémiante et qui peuvent par conséquent s'avérer utiles dans le traitement et/ou la prophylaxie du diabète et/ou autres altérations ou complications inhérentes au diabète, tel que l'hyperglycémie ou lhyperlipidémie. La présente invention se rapporte également à une méthode pour leur production.
Patent MA-27686-A1 (MA)
Title: Collecteur de courant elastique
Inventor: OLDANI DARIO
IPC: H01M8/02
Filed: 2004-05-04
Abstract: L'invention décrit un collecteur de courant pour cellules électrochimiques, se composant d'une juxtaposition de couches compressibles et résilientes de fils métalliques, qui impartit une charge mécanique prédéterminée dans une grande plage de compression.
Patent MA-38112-A1 (MA)
Title: Dérivés d'imidazopyridazine en tant que modulateurs d'un récepteur gabaa
Inventor: OMOTO KIYOYUKI
IPC: C07D487/04
Filed: 2013-12-04
Abstract: La présente invention se rapporte au domaine des composés chimiques et concerne des dérivés d'imidazopyridazine. Plus particulièrement, l'invention concerne des dérivés de 4-(biphényl-3-yl)-7h-imidazo[4,5-c]pyridazine de formule (i) et les sels pharmaceutiquement acceptables de ceux-ci, où r
Patent MA-38399-A1 (MA)
Title: Formulation sous forme de comprimé, utile pour traiter l'insuffisance cardiaque aiguë et l'insuffisance cardiaque chronique
Inventor: BI MINGDA
IPC: C07D213/75
Filed: 2015-09-09
Abstract: L'invention concerne certaines formulations pharmaceutiques d'omécamtiv mécarbil et leurs procédés de préparation et d'utilisation.
Patent UY-25606-A1 (UY)
Title: Un metodo para formar un bloque de alimentacion animal y el bloque asi preparado
Inventor: STANSBY MARK RICHARD
Filed: 1999-07-12
Abstract: Esta invención presenta un método para formar un bloque de alimentación animal que comprende los pasos de mezclar al menos un componete de alimentación animal con sulfato de magnesio y óxido de magnesio reactivo para formar una composición, regulando el nivel de agua de la composición a un nivel tal para permitir verter la composición dentro de un molde, permitiendo que la composición se solidifique al menos parcialmente en el molde. La cantidad de sulfato de magnesio y óxido de magnesio en el bloque puede variar para favorecer los otros aditivos en el bloque, la resistencia a la intemperie deseada, dureza del bloque y similares. La composición de alimentación puede contener una variedad de aditivos que pueden incluir aditivos orgánicos e inorgánicos. Los aditivos inorgánicos se seleciona del grupo que consiste en: sal, urea, compuestos de calcio tales como carbonato de calcio, bicarbonato de calcio, fosfato de calcio, sulfato de calcio; aditivos de fosfato tales como polifosfato amónico y fosfato tetra-sódico y la composición comprende entre aproximadamente 5 hasta 80% por peso del componente. Otros aditivos pueden incluir alimentos tales como semilla de algodón, grano molido, soja molida, afrecho, lupinos, melaza, borra del jugo de cana, otros subproductos de melaza (secos); granos, cereales, legumbres, paja, heno, escamas de soja, alfalfa seca, harina de soja, afrecho de trigo, maíz; grasas tales como grasas animales y vegetales comestibles y aceites, por ejemplo aceite de soja, aceite de semilla de algodón, aceite de pescado, grasa, sebo, grasa vacuna y similares; harina de cebada, harina de sangre, suero de lecho seco, harina de linaza, carne y harina de huesos, harina de maní, harina de arroz y harina de girasol. Si estos aditivos se encuentran presentes, se pueden encontrar preentes en una cantidad de hasta aproximadamente 50% por peso o más. La composición puede incluir diversas vitaminas, elementos trace y minerales, y de encontrarse presentes lo están en una cantidad de hasta aproximadamente 10% por peso o más. Estos ingredientes incluyen sulfato de cobre, sulfato de cobalto, sulfato de zinc, sulfato de magnesio, azufre, óxido de zinc, sulfato ferroso, óxido ferroso, yodos, yodato de potasio, selenio y sus compuestos tales como selenito sódico y similares. Las vitaminas agregadas pueden incluir las vitaminas A, E y las vitaminas del grupo B, D y K. Puede incluir también aditivos tales como medicamentos, antimicróbicos, probióticos, enzimas, insecticidas y antihelmínticos en una cantida aproximadamente de 25% por peso.