baber/WOPTO huggingface dataset:
Patent DE-69027024-T2 (DE)
Inventor: LIOTTA LANCE
IPC: G01N33/573
Filed: 1990-03-01
Granted: 1997-01-09
Abstract: A family of metalloproteinases exist which cleave extracellular matrix molecules. These metalloproteinases are secreted in a latent inactive form and require activation in order to specifically cleave the preferred substrate. A series of peptides have been prepared based on the complete sequence analysis of type IV procollagenase. Peptide inhibitors were synthesized which correspond to cysteine repeat regions and histidine containing regions; the mechanism of action of these peptides involves inhibition of binding of the enzyme to the substrate. Peptide inhibitors were synthesized which correspond to the peptide cleaved off during activation, and constitute a novel class of metalloproteinase inhibitors. These inhibitors are members of a series of peptides which contain the core amino acid sequence RKPRC or analogs thereof. The cysteine residue is required for activity. Affinity purified antibodies directed against specific peptides can be used to a) detect any general metalloproteinase enzyme with the sequence in part VAAHE or PRCGNPD, and distinguish it from other known members of the metalloproteinase family, b) block functional domains resulting in the inhibition of enzyme activity, and c) distinguish latent from activated forms of the enzyme.
Patent DE-69029934-T2 (DE)
Inventor: HYMAN CAROLYN
IPC: C07K16/22
Filed: 1990-08-29
Granted: 1997-07-24
Abstract: The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the means to generate sufficient quantities of substantially pure BDNF for clinical use. In a specific embodiment, BDNF may be used to promote the survival of substantia nigra dopaminergic neurons and basal forebrain cholinergic neurons, thereby providing a method for treating, respectively, Parkinson's disease and Alzheimer's disease. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen. Further, by permitting a comparison of the nucleic acid sequences of BDNF and NGF, the present invention provides for the identification of homologous regions of nucleic acid sequence between BDNF and NGF, thereby defining a BDNF/NGF gene family; the invention provides a method for identifying and isolating additional members of this gene family.
Patent DE-69032899-T2 (DE)
Inventor: LALANDER MAGNUS
IPC: H02M3/315
Filed: 1990-11-02
Granted: 1999-08-26
Abstract: PCT No. PCT/SE90/00710 Sec. 371 Date Apr. 22, 1992 Sec. 102(e) Date Apr. 22, 1992 PCT Filed Nov. 2, 1990 PCT Pub. No. WO91/07807 PCT Pub. Date May 30, 1991.A DC/DC power transformer is provided which is an arrangement for direct transformation of high electric power from one DC voltage level to another DC voltage level without an intermediate AC voltage network. The DC voltage is today basically used for transmission of high electric power at long distances. The DC voltage levels for these transmissions are normally high. The DC/DC power transformer allows several DC voltage levels to be used in one and the same DC voltage network. The principle for this arrangement is that the valve windings (43, 45) from one or several converter transformers (47) are connected to two valve bridges, which generate opposing cyclically variating magnetic flows in the transformer cores (44). One of the valve bridges is operated as an inverter (42) and the other as a rectifier (46) and in this manner the power is transformed from one DC voltage level (Ud1) to another (Ud2). At high voltage levels the leakage inductances in the transformers will be high as a consequence of the insulation levels and therefore special arrangements must be made in order to commutate the magnetic energy from one phase of the transformer to another without creating great losses.
Patent DE-69034000-T2 (DE)
Inventor: DOW ROBERT J
IPC: A61P9/00
Filed: 1990-06-21
Granted: 2003-06-05
Abstract: Piperazine derivatives, particularly ranolazine, are useful for treatment of tissues experiencing a physical or chemical insult, and specifically for treating shock conditions.
Patent DE-69100629-T2 (DE)
Inventor: CARDINAL JOHN
IPC: A61M37/00
Filed: 1991-03-11
Granted: 1994-03-10
Abstract: There is disclosed an insert for the orifice of a ruminal bolus. The insert fits within the exit orifice of the ruminal bolus such that the medicated paste being discharged passes through the insert creating a back pressure within the paste compartment of the bolus which improves the performance of the bolus. The insert also prevents foreign objects from becoming lodged in the orifice. The insert consists of a grid-like series of openings with insert members extending into the orifice for a significant portion of the total length. Integral with the insert is a flange which secures the insert within the orifice and prevents it from being removed from the orifice or from being driven into the orifice.
Patent DE-69105041-T2 (DE)
Inventor: KAMINSKI CHRISTOPHER ANTHONY
IPC: H02K3/24
Filed: 1991-05-24
Granted: 1995-04-13
Abstract: Rotor slot insulation (12, 13) for dynamoelectric machines having rotors with subslots includes two slot armors (12, 13). Each extends (12a, 13a) in an offset manner to the transition between the rotor slot and subslot (10) and into the subslot a distance sufficient to eliminate the need for a subslot cover and for providing a creepage path of sufficient length as to prevent creepage between slot windings and rotor iron. <IMAGE>
Patent DE-69108363-T2 (DE)
Inventor: PORTER JOHN ROBERT
IPC: C07D209/20
Filed: 1991-12-03
Granted: 1995-08-31
Abstract: Compounds of formula (I): <CHEM> are described wherein R represents a -CONHOH, carboxyl (-CO2H) or esterified carboxyl group; R<1> represents an optionally substituted alkyl, alkenyl, aryl, aralkyl, heteroaralkyl or heteroarylthioalkyl group;R<2> represents an optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkoxy, or aralkylthio group, or an amino (-NH2), substituted amino, carboxyl (-CO2H) or esterified carboxyl group; R<3> represents a hydrogen atom or an alkyl group;R<4> represents a hydrogen atom or an alkyl group; R<5> represents a group -[Alk]nR<6> where Alk is an alkyl or alkenyl group optionally interrupted by one or more -O- or -S- atoms or -N(R<7>)- groups [where R<7> is a hydrogen atom or a C1-6alkyl group], n is zero or an integer 1, and R<6> is an optionally substituted cycloalkyl or cycloalkenyl group; X represents an amino (-NH2), or substituted amino, hydroxyl or substituted hydroxyl group; and the salts, solvates and hydrates thereof. The compounds are metalloproteinase inhibitors and in particular have a selective gelatinase action, and may be of use in the treatment of cancer to control the development of tumour metastasises.
Patent DE-69110916-T2 (DE)
Inventor: DUHON EDWARD W
IPC: H01H1/14
Filed: 1991-01-21
Granted: 1995-11-16
Abstract: A normally-closed electrical switch having a plurality of electrically conductive contacts normally arranged in overlapping electrical communication. A preferred embodiment of the present invention also comprises a pressure directing mechanism for directing and actuating pressure to specific portions of the electrically conductive elements. The normally-closed electrical switch of the present invention interrupts an electrical circuit in response to an applied pressure. <IMAGE>
Patent DE-69112851-T2 (DE)
Inventor: TREBOT ALAIN
IPC: B29C49/06
Filed: 1991-01-03
Granted: 1996-02-22
Abstract: The invention relates to a mandrel (2) for injection blow-moulding of a hollow article made from plastic, having a hollow cylindrical body (8) comprising a portion (A) for connecting to a blow-moulding injection machine axially extended by a portion (B) for positioning in the wall of a mould associated with the machine which is itself axially extended by a blowing portion (C) intended to be housed in the cavity of the mould. The mandrel comprises first means for intermittent blowing via a first orifice (4) for blowing a previously injected parison around the blowing portion (C). The first means are arranged in the hollow article (8). The mandrel comprises, arranged in the hollow article (8), second means for intermittent blowing via a second blowing orifice (6), the first and second orifices (4, 6) being separate and axially spaced with respect to each other. 
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Patent DE-69114307-T2 (DE)
Inventor: INSTANCE DAVID JOHN
IPC: G09F3/02
Filed: 1991-08-30
Granted: 1996-05-02
Abstract: A self-adhesive label comprising a multilaminar label portion (64), a self-adhesive laminar material (72) extending over, and adhered by its self-adhesive surface to, the multilaminar label portion thereby to form two self-adhesive edge portions (72,74) thereof on opposed sides of the multilaminar label portion, and a backing (66) of release material to which the two edge portions are releasably adhered by a self-adhesive rear surface thereof and to which the multilaminar label portion is releasably adhered by a layer of pressure-sensitive adhesive (68). There is also provided a method for producing such a label.
Patent DE-69116169-T2 (DE)
Inventor: ANDREWS JOSEPH
IPC: B65G15/02
Filed: 1991-02-20
Granted: 1996-05-15
Abstract: A sanitary conveyor system is disclosed in which a conveyor bed, with or without curves, is mounted on a frame for movement of food trays between a plurality of work stations or movement of soiled trays from the cafeteria to the ware-washing area. A central box channel is mounted remote from the work stations and is provided juxtaposed to and below the pair of conveyor beds. The conveyor system includes a first set of pulleys being disposed adjacent to the tail end of the conveyor beds which are horizontally aligned and angled upwardly from the box channel to the conveyor beds such that each belt in the lower return flight path of the box channel are moved upwardly to the corresponding upper flight path of the conveyor bed. A second set of pulleys is disposed adjacent to the drive end of the conveyor bed and operatively connected to a belt drive unit such that belts are moved from the upper flight path of the conveyor bed to the lower return flight path of the box channel. Accordingly, in the lower return flight path, the belts are constrained within the box channel during their lower return flight path remote from the work stations.
Patent DE-69116383-T2 (DE)
Inventor: MALABARBA ADRIANO
IPC: C07K7/64
Filed: 1991-11-21
Granted: 1996-05-30
Abstract: Hexapeptides of formula (I) deriving from aglucoteicoplanin and their salts with acids and bases as well as their inner salts, wherein R is hydrogen or a protecting group of the amino moiety. The products of formula (I), wherein R is hydrogen, possess antimicrobial activity in particular against coagulase-negative strains and some S. aureus and S. epidermidis strains which have low sensitivity toward teicoplanin. The hexapeptides are produced by reductive cleavage of aglucoteicoplanin with alkali metal borohydrides in the presence of a hydroalcoholic mixture as solvent.
Patent DE-69118565-T2 (DE)
Inventor: YOSHIOKA TAKAO
IPC: C07D277/34
Filed: 1991-02-06
Granted: 1997-01-09
Abstract: Compounds of formula (I): <CHEM>   [in which: A is a group of formula (II) or (III): <CHEM> W is methylene, carbonyl or >C=N-OV, where V is hydrogen, sulpho, acyl or alkyl; U is methylene, or W is absent and U is a carbon-carbon double bond between A and -CR<1>(OH)-; R<1>, R<2>, R<3> and R<4> are each hydrogen or alkyl; Y<1> and Y<1> are each hydrogen or a hydroxy-protecting group; and n is 1, 2 or 3] and salts thereof have anti-diabetic activity in mammals. Methods of preparing them are also provided.
Patent DE-69201033-T2 (DE)
Inventor: SCHAFER WOLFGANG
IPC: A23L17/00
Filed: 1992-08-26
Granted: 1995-05-11
Abstract: Deep frozen food product comprising a portion of raw or an underdone food material and a coating, said coating comprising an adhesive material, such as a batter, and unfried, deep frozen, moist particulate seed- root- or tuberous vegetable.
Patent DE-69207827-T2 (DE)
Inventor: HERRENSCHMIDT PATRICE
IPC: C10G35/10
Filed: 1992-06-19
Granted: 1996-06-20
Abstract: Process for replacing with a second catalyst a first catalyst in the solid state circulating in a device for processing hydrocarbons comprising at least one processing reactor (1) in which the catalyst is present as a moving bed. According to the invention:   - the first catalyst is drawn off downstream of the or each reactor (1) in the direction of circulation of the catalyst; - the second catalyst is simultaneously injected upstream of the or each reactor; - the packing density of the material drawn off downstream of the or each reactor is measured continuously; - and the drawing-off of the first catalyst and the injection of the second catalyst into the reactor in question are stopped when the packing density thus measured is equal to that of the second catalyst.   <IMAGE>
Patent DE-69212042-T2 (DE)
Inventor: KAWASAKI HIDEJI
IPC: H01L33/40
Filed: 1992-04-14
Granted: 1997-01-02
Abstract: A light emitting device includes a syepped non-nucleation layer (102). Compound semiconductor islands, each consisting of n-type and p-type semiconductor regions (104,105), are formed along a wall surface (109) constituting the boundary of the step, and outer (106) and inner electrodes (107) are formed thereon, with the wiring section for the outer electrodes being formed on the surface of the thickest portion of the non-nucleation layer. The electrodes and the electrode wiring section are positioned substantially at the same level, thus attaining a reduction in resistance value and an increase in strength. <IMAGE>
Patent DE-69300673-T2 (DE)
Inventor: DEVEAU JACQUES
IPC: C14C15/00
Filed: 1993-11-25
Granted: 1996-05-02
Abstract: Device for distributing a pulverulent product, comprising:     - a carrying structure (1); - two parallel rails (5) capable of being moved vertically in relation to this structure; - means for moving these rails (5) vertically in concordance in relation to the structure (1) from a low position to a high position and vice versa; - a hopper (10) capable of being filled with the pulverulent product (11) to be distributed, this hopper resting on a trolley (9) with wheels (8) on the rails (5) and having at least one distribution orifice in its lower part; - means (15) for imparting to the trolley (9) carrying the hopper (10) a movement on the rails (5) in either direction.   Use for spreading salt on animal hides. <IMAGE>
Patent DE-69304480-T2 (DE)
Inventor: PELLEGRINI ALFRED
IPC: A63C17/14
Filed: 1993-10-15
Granted: 1997-01-02
Abstract: A braking device, particularly usable for skates (2) including a shoe (3) composed of a quarter (4) articulated to a shell (5) in turn associated with a supporting frame (6) for one or more wheels (7). The device comprises at least one rod-like element (8) which is rotatably associated with the quarter and is slidingly associated with a guide (15) formed on a wing (16) which is associated with the frame (6). The rod-like element is kinematically connected to a braking element (19) articulated to the frame. When the quarter is rotated backwards, the rod-like element causes the braking element to rotate so that it interacts with the ground. <IMAGE>
Patent DE-69310369-T2 (DE)
Inventor: CURTZE JUERGEN
IPC: C07D295/18
Filed: 1993-07-08
Granted: 1997-08-28
Abstract: PCT No. PCT/EP93/01803 Sec. 371 Date Mar. 16, 1995 Sec. 102(e) Date Mar. 16, 1995 PCT Filed Jul. 8, 1993 PCT Pub. No. WO94/14241 PCT Pub. Date Jan. 20, 1994.The invention provides a process for the preparation of 3,3-diaryl acrylic acid amides of the general formula    <IMAGE>  (I)  in which A, B and Q are as defined in the specification, by condensing a compound of formula    <IMAGE>  (II)  with a compound of formula CH3-CO-Q (III) in which Q has the meaning given above, in a solvent in the presence of an alkali metal hydroxide, characterised in that the solvent is selected from alkanes, cycloalkanes or mixtures thereof.
Patent DE-69315719-T2 (DE)
Inventor: COUDERC BERNARD
IPC: A63C5/075
Filed: 1993-01-28
Granted: 1998-04-30
Abstract: The invention relates to a device aimed at modifying the pressure distribution of a ski, such as, in particular, an alpine ski, over its sliding surface (surface-sole). The device is characterised in that it comprises a sensor member (60) capable of sensing the vertical stresses of the boot and, moreover, linking means (43, 44) for transmitting at least towards one of the ends of the ski in the form of a bending moment a part at least of the vertical thrust of the boot downwards sensed by the sensor (60). The linking means (43, 44) comprise calibrating means (43, 44, 55) for inducing a prestress. The linking means have, furthermore, a sensor (60) sensitive to the presence or the absence of the boot in order automatically to control the calibrating means in accordance with the presence or the absence of the boot. The invention also relates to a ski brake. The brake arms are carried by one of the levers (44) constituting the linking and calibrating means.
Patent DE-69323751-T2 (DE)
Inventor: COLLETTE WAYNE
IPC: B32B7/027
Filed: 1993-07-02
Granted: 1999-07-01
Abstract: A method of forming a multi-layer polyester preform and container, particularly suitable for refillable PET carbonated beverage bottles, having an interior layer of high copolymer polyester material which resists hazing in the preform injection stage, and at least one exterior layer of a polyester to achieve enhanced strain-induced crystallization in the exterior layer during blow molding. The container can withstand higher caustic wash temperatures and exhibits reduced flavor carryover from one product to another.
Patent DE-69329645-T2 (DE)
Inventor: CASTRO PINEIRO JOSE LUIS
IPC: A61P25/04
Filed: 1993-03-29
Granted: 2001-05-10
Abstract: PCT No. PCT/GB93/00652 Sec. 371 Date Sep. 29, 1994 Sec. 102(e) Date Sep. 29, 1994 PCT Filed Mar. 29, 1993 PCT Pub. No. WO93/20066 PCT Pub. Date Oct. 14, 1993A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT1-like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.
Patent DE-69333716-T2 (DE)
Inventor: SUFFIS ROBERT
IPC: A61K/
Filed: 1993-09-22
Granted: 2005-11-24
Abstract: Described is a fragrancing composition having fragrancing components that are not activated until, e.g., application to the skin of a human. The composition is alkaline or (if anhydrous) capable of producing an alkaline pH when in contact with water, prior to application, and includes (1) a vehicle such that when the composition is in contact with water, prior to application, the composition is at an alkaline pH; and (2) at least one potential fragrance that is at least one compound having little or no odor in the alkaline composition but which, e.g., is hydrolyzed in a lower pH environment to produce compounds having a relatively strong aroma. Upon application of the alkaline composition to the skin surface, the strong buffering capacity of the skin (the surface of which has a normal pH of 5.5-7.0) neutralizes alkalinity of the composition (lowers pH) so as to restore normal skin surface pH; the potential fragrance is then hydrolyzed at the lower pH to release the compound having relatively strong aroma. The potential fragrance can be incorporated as a component of a transparent (clear) deodorant stick composition for application to human axillary regions, the fragrance being released after application to the body.
Patent DE-69401965-T2 (DE)
Inventor: COHEN ISSAC
IPC: H02M3/335
Filed: 1994-01-21
Granted: 1997-10-09
Abstract: A switch mode power converter having an overload protection system is disclosed. The system includes an input stage having an input voltage source. A switching circuit for coupling said input source to an output stage is provided. The output stage further includes a first filter circuit providing an output current to a load circuit. A second filter circuit is coupled to the output stage providing a voltage proportional to the output current and to internal temperature of the switch mode converter. An error amplifier responsive to the voltage derived by a second filter and a reference voltage, generates an error signal proportional to the difference of the voltage applied to the error amplifier. The error signal adjusts the operating parameters of the switching circuit. <IMAGE>
Patent DE-69409395-T2 (DE)
Inventor: DEGROOT ROY
IPC: G06V10/145
Filed: 1994-10-21
Granted: 1998-10-15
Abstract: A method for identifying characters (1) written on substrates (2), comprising at least the steps of illuminating, observing and identifying the characters. According to the method, the characters are illuminated slantwise by a light source (S1) relative to a minimal planar surface (3) containing all the characters, and also observed slantwise relative to said surface (3), advantageously by an electronic camera (8), and they are identified by means of a CPU comprising neural network recognition software. A device for identifying characters (1) written on substrates (2) and thereby implementing said identification method is also disclosed. The method and device are useful for producing integrated circuits.
Patent DE-69430069-T2 (DE)
Inventor: DOWD MICHAEL
IPC: A61F2/30
Filed: 1994-12-08
Granted: 2002-10-10
Abstract: Surgically implantable shaped materials, e.g., sheets, are fabricated from elongate bone particles, advantageously those that have been demineralized. The materials when applied to a bone repair site enhance or accelerate new bone ingrowth by any one of a variety of biological and/or mechanical mechanisms.
Patent DE-69433167-T2 (DE)
Inventor: KEARNEY MICHAEL M
IPC: C13B20/14
Filed: 1994-12-05
Granted: 2004-07-08
Abstract: A process for purifying the raw juice (diffusion juice) obtained from sugar beets replaces the traditional liming and carbonation purification methods with ion exchange softening and chromatographic separation operations.
Patent DE-69508248-T2 (DE)
Inventor: PRICE JEFFREY H
IPC: G02B21/26
Filed: 1995-06-30
Granted: 1999-11-04
Abstract: An apparatus for generating a volume image, for incorporation in an autofocus system for scanning microscopy is provided, including a plurality of imaging devices (436,481) which are coupled to an image forming apparatus (437, 440, 481) and used to form a plurality of electronic image representations. The storage (443) and processing (442)of successive pluralities of electronic image representations, wherein the plurality of electronic image representations represent images at respective image planes of the plurality of image planes, allows one to acquire a volume image. <IMAGE>