Patent SG-11201901790Y-A (SG)
Title: Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof
Inventor: BOYINGTON JEFFREY
IPC: C07K14/195
Filed: 2017-09-01
Abstract: WO 18/0 45 308 Al ectociorriein FIG. 1B (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 March 2018 (08.03.2018) WIP0 I PCT omit VIII °nolo olommoil nuoiflo oimIE (10) International Publication Number WO 2018/045308 Al (51) International Patent Classification: A61K 39/12 (2006.01) CO7K 14/005 (2006.01) A61K 39/145 (2006.01) CO7K 14/195 (2006.01) (21) International Application Number: PCT/US2017/049894 (22) International Filing Date: 01 September 2017 (01.09.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/383,267 02 September 2016 (02.09.2016) US (71) Applicant: THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES [US/US]; Office Of Technology Transfer, Na- tional Institute, Of Health, 6011 Executive Blvd., Suite 325, Msc 7660, Bethesda, MD 20892-7660 (US). (72) Inventors: BOYINGTON, Jeffrey, C.; 22816 Timber Creek Ln., Clarksburg, MD 20871 (US). GRAHAM, Barney, S.; 301 Pure Spring Crescent, Rockville, MD 20850 (US). MASCOLA, John, R.; 15301 Emory Lane, Rockville, MD 20853 (US). YASSINE, Hadi, M.; Biomed- ical Research Center (brc), Qatar University, Po Box 2713, Doha, Qatar (QA). CORBETT, Kizzmekia, S.; 11101 Georgia Ave., #339, Wheaton, MD 20902 (US). MOIN, Syed, M.; 13806 Clarkwood Lane, Laurel, MD 20707 (US). WANG, Lingshu; 11416 Grey Colt Lane, North Potomac, MD 20878 (US). KANEKIYO, Masaru; 455 Willard Ave., Chevy Chase, MD 20815 (US). (74) Agent: STERN, Richard, J.; Sheridan Ross P.C., 1560 Broadway, Suite 1200, Denver, CO 80202 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: STABILIZED GROUP 2 INFLUENZA HEMAGGLUTININ STEM REGION TRIMERS AND USES THEREOF HA-ferritin nanaparticles 11A idEcarrmil 'emir (57) : Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric sub- unit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies. HA efabillseill stamagt41 TenittnnantiMileles [Continued on next page] WO 2018/045308 Al MIDEDIMOMMIDEFIDIDOVIVI011IMMODEVOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))