baber/WOPTO huggingface dataset:
Patent SG-11201805993U-A (SG)
Title: Genetically modified non-human mammals by multi-cycle electroporation of cas9 protein
Inventor: WANG HAOYI
IPC: C12N15/873
Filed: 2017-01-17
Abstract: FIGA A biffereot timOs.ofER profOn hiccia ?rf+tsortlt,rt;...,- . -001‘ W O 20 17 / 124086 Al Different times of EP, Czsc protein WT 4 5 8 TP WhOl9 Ecc brain Ettibryo 49— (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/124086 Al 20 July 2017 (20.07.2017) WIPO I PCT 1111111111111101110111111111110101111101110111010111111111111011111111111111110111111 (51) International Patent Classification: AO1K 67/027 (2006.01) C12N 15/873 (2010.01) C12N 15/87 (2006.01) (21) International Application Number: PCT/US2017/013754 (22) International Filing Date: 17 January 2017 (17.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/279,023 15 January 2016 (15.01.2016) US (71) Applicant: THE JACKSON LABORATORY [US/US]; 600 Main Street, Bar Harbor, ME 04609 (US). (72) Inventors: WANG, Haoyi; Building 956, Unit 1, Room 202, Zhong guan can nan san Street, Beijing (CN). WANG, Wen-Bo; 600 Main Street, Bar Harbor, ME 04609 (US). (74) Agents: LU, Yu et al.; McCarter & English, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: GENETICALLY MODIFIED NON-HUMAN MAMMALS BY MULTI-CYCLE ELECTROPORATION OF CAS9 PROTEIN (57) : The invention described herein provides high throughput methods and reagents for generating transgenic an- imals (e.g., non-human mammals) through introducing a CRISPR/Cas9 system com- prising a Cas9 protein into gametes or preimplantation stage embryos (e.g., one- cell embryos or zygotes) via multiple cycles (e.g., 4- 10 cycles) of electropora- tion, leading to genetically inheritable modification to the genome of the animal.
Patent SG-11201806099W-A (SG)
Title: Method and apparatus for accessing flash memory device
Inventor: SHI LIANG
IPC: G06F12/02
Filed: 2016-02-19
Abstract: METHOD AND APPARATUS FOR ACCESSING FLASH MEMORY DEVICE Embodiments of the present invention provide a method and an apparatus for accessing a flash memory device, so as to optimize access efficiency of a flash memory device. The method includes: receiving, by a storage controller, an access request; obtaining, by the storage controller, historical access information of a to-be-accessed storage area, where the historical access information includes a historical access type of the to-be-accessed storage area, and an access type of access to a flash memory device includes a write operation and a read operation; and performing, by the storage controller, an access operation on the to-be-accessed storage area according to the historical access information and an access type of the access request. Data is classified into three types: read-only data, write-only data, and cross-access data, and the three types of data are distinguished from one another by using historical access information and an access type of a current access request, thereby increasing a read speed of read-only data, increasing a write speed of write-only data, and improving overall access efficiency of a flash memory device. Fig. 6
Patent SG-11201808753W-A (SG)
Title: Botulinum toxin prefilled syringe system
Inventor: VOGT MARKUS
IPC: A61M5/178
Filed: 2017-06-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/220553 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, A61M 5/315 (2006.01) A61M 5/1 78 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (21) International Application Number: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, PCT/EP2017/065050 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (22) International Filing Date: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 20 June 2017 (20.06.2017) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (30) Priority Data: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 16001404.9 22 June 2016 (22.06.2016) EP TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (71) Applicant: MERZ PHARMA GMBH & CO. KGAA MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, [DE/DE]; Eckenheimer Landstrasse 100, 60318 Frankfurt TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, am Main (DE). KM, ML, MR, NE, SN, TD, TG). (72) Inventor: VOGT, Markus; Bertha-Bagge-Strasse 64, 60438 Frankfurt am Main (DE). Published: — with international search report (Art. 21(3)) (74) Agent: WALLINGER RICKER SCHLOTTER TOST- _ MANN PATENT- UND RECHTSANWALTE PART- - NERSCHAFT MBB et al.; ZweibriickenstraBe 5-7, 80331 = Munich (DE). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = (54) Title: BOTULINUM = = - = ii:',1 TOXIN PREFILLED SYRINGE SYSTEM (57) : The present invention relates a botulinum toxin prefilled syringe sys- 16 tem with desirable injection force characteristics, in particular low gliding force and low break loose force, comprising a syringe barrel of glass containing a liquid botulinum = timminffingas toxin a and a device as a tip a needle composition, plunger stopper closure such cap or _ = = 42 = = = 22 _ 3 2 Il 18 en ir) ir) 0 ei 3q ei IN 1-1 0 FIG. ei '-'a = A . r l , , ,‘ q 0 t . ' , = :‘• \A .er:4 1 I 1 1 ,1 l i t e0 4 7. shield. In addition, the present invention relates to a kit comprising the botulinum toxin _ l • 14 prefilled syringe system, and optionally instructions for use, and to the use of the botu- 1 linum toxin prefilled syringe system in therapeutic and cosmetic applications. 2.,:) 12- p 3 0.:!• 22 32 C
Patent HU-190217-B (HU)
Inventor: TOEROEK TIVADAR
IPC: F24H1/18
Filed: 1984-01-02
Abstract: A találmány olyan folyadékmelegítő, amelynek sugárzásnak kitett összefüggő belsőterű kollektorában a hőhatás folytán munkafolyadék (13) párolog el, a gőz a melegítendő folyadék tárolótartályába, (9) nyúló fűtőcsöben (12) kondenzálva leadja latens hőjét, amellyel a folyadékot melegíti, majd a kondenzátum ugyanazon vezetéken visszafolyik a kollektorba, amelyen a gőz a fűtőcsőbe (12) került. A célszerűen csőjáratos kollektor csőjáratai (2) legmélyebb pontjukon összenyílnak (3) belső felületeiket legalább részben kapilláris rendszer (7) borítja, és a teljes belső tér a legmélyebb ponttól a fűtőcső (12) legtávolabbi pontjáig folyamatosan emelkedő elhelyezésű. (1. ábra) Ily módon a kollektor csőjáratainak (2) és a fűtőcsőnek (12) összekötött belső tere gravitáció segítette hőcsőnek van kialakítva. Előnyös kivitelnél a fűtőcső (12) legtávolabbi pontja a tárolótartályon (9) túl nyúlik, belső terében pedig indifferens gázt is tartalmaz, miáltal a melegítendő folyadék túlfűtése elkerülhető. További előnyös kivitelnél a kollektorjáratok (2) felfelé tágulóak; összehengerelt lemezek előre kijelölt helyen nyomással történő felfújásával készültek; a kondenzátum gyüjtőéren jut vissza a gőzvezetéken belül; a gőzt belül egy gőzcsö a fütöcső (12) legmagasabb pontjáig vezeti és a melegítendő folyadék tárolótartályát (9) osztólemezek tagolják. 9   12  1.ABRA -1-
Patent IS-1521-B (IS)
Inventor: GARAT MICHEL
IPC: B22C9/04
Filed: 1987-11-16
Abstract: 1. A lost foam casting process for the casting of metal objects, in particular of aluminium and its alloys, in which a pattern of the product to be obtained which is produced from a foam of organic material is immersed into a mould constituted by a bath of dry sand containing no binder, characterised in that an isostatic gas pressure is applied by a gradual increase to the selected value to the mould after ? the mould has been filled with the molten metal and before the solidified fraction of metal exceeds 40 percent by weight.
Patent YU-47600-B (YU)
Title: Utikač - utičnica produžnog razvodnog kabla za telefon
Inventor: MIRILO S
IPC: H01R29/00
Filed: 1986-01-08
Abstract: UTIKAČ - UTIČNICA PRODUŽNOG RAZVODNOG KABLA ZA TELEFON, naznačen time, što je unutrašnji otvor (7), s jedne strane tela (1) utikača - utičnica, umetnuta podloška (12) i na nju oslonjen nosač (2) sa kontaktnim šiljcima (11), a sa druge strane tela (1) utikača - utičnice umetnut je otvor (7) drugi nosač (5), na kome su sa vijcima (4) pričvršćene kontaktne čaure (8), pri čemu su nosači (2,5) vijcima (3) pritegnuti za telo (1) utikača - utičnice. Prijava sadrži još 1 zavisan zahtev.
Patent YU-46779-B (YU)
Inventor: BROADHURST J M
IPC: C07F9/36
Filed: 1988-01-18
Abstract: POSTUPAK ZA PROIZVODNJU DERIVATA FOSFINSKE KISELINE formule u kojoj R1 predstavlja atom vodonika ili grupe C1-C6-alkil ili aril-(C1-C6-alkil), R2 predstavlja C2-C5-alkil grupu, R3 predstavlja bočni niz prirodne alfa-amino kiseline u kojoj svaka funkcionalna grupa koja postoji je po izboru zaštićena ili je svaka prisutna amino grupa po izboru acilirana ili sulfonirana, ili je bilo koja prisutna karbonil grupa po izboru amidovana pod uslovom da R3 nije atom vodonika niti metil grupa, R4 predstavlja atom vodonika ili metil grupu, ili R3 i R4 istovremeno predstavljaju grupu formule -(CH2)n- u kojoj je n broj od 4 do 11, R5 predstavlja atom vodonika ili C1-C6-alkil, karboksil, C1-C6-alkilaminokarbonil grupu, X predstavlja bilo koju cikličnu imido grupu izvedenu iz alifatične ili aromatične dikarboksilne kiseline, iz neke N-karboksiamino kiseline, iz neke azadikarboksilne kiseline ili iz neke O-karboksihidroksi kiseline ili grupe sa formulom kod koje je Ra bočni niz prirodne alfa -amino kiseline u kojoj je svaka prisutna funkcionalna grupa po želji zaštićena ili je bilo koja prisutna amino grupa po želji acilovana ili sulfonovana ili je svaka prisutna karbonil grupa po želji amidovana, Rb predstavlja atom vodonika ili i Ra i Rb zajedno predstavljaju trimetilensku grupu, Rc predstavlja bočni niz prirodne alfa-amino kiseline kod koje je bilo koja funkcionalna grupa po želji zaštićena ili je bilo koja prisutna amino grupa po želji acilovana ili sulfonovana ili je bilo koja prisutna karboksilna grupa po želji amidovana, Rd predstavlja atom vodonika ili i Rc i Rd zajedno predstavljaju trimetilensku grupu i Re predstavlja zaštitnu grupu ili neki acil, C1-C6-alkilsulfonil ili arilsulfonilsku grupu i njihovih farmaceutski pogodnih soli, naznačen time, što se tretira jedinjenje opšte formule gde R1, R2, R3, R4, R5 i X imaju značenje definisana u zahtevu 1, a R6 predstavlja C1-C6-alkil grupu, sa vodonik bromidom u sirćetnoj kiselini na sobnoj temperaturi ili sa trifluorosirćetnom kiselinom ili sa halotrialkilsilanom u internom organskom rastvaraču na sobnoj temperatiri i što se ukoliko se želi vrši funkcionalno modifikovanje prisutnog reaktivnog substituenta na cikličnoj imidnoj grupi označenoj sa X u dobijenom jedinjenju formule I, tj. redukovanje nitro grupe u amino grupu i/ili konvertovanje aril-(C1-C8-alkoksi) grupe u hidroksi grupu pomoću katalitičke hidrogenizacije i/ili zamenom aktiviranog aromatičnog atoma vodonika sa atomom halogena pomoću halogenizacije, i time što se po želji vrši konverzija jedinjenja formule I u farmaceutski prihvatljivu so. Prijava sadrži još 6 zavisnih zahteva.
Patent AT-385367-B (AT)
Title: Warning device for high-voltage lines, cable railways (aerial ropeways) and the like, comprising a row of warning balls
IPC: H02G7/00
Filed: 1986-03-13
Granted: 1988-03-25
Abstract: The device consists of a row of warning balls 1. The propulsion gear (drive) 6 via which the warning balls are displaceably suspended on a bearer cable (catennary wire) 2 is accommodated in the interior of the ball and comprises two guiding rollers (roller idlers, castors) 7 which are arranged in the vicinity of the through slots 12 for bearer cable and holding cable (traction cable) 10 which are mounted on a common base plate 8 on which the holding cable is clamped in place. Carrier and holding cables are symmetrically arranged with reference to the axis of gravity (centroid axis) of the warning ball. <IMAGE>
Patent AT-403113-B (AT)
Title: Bottom part for shoes, in particular shoe sole
IPC: A43B13/14
Filed: 1995-04-27
Granted: 1997-11-25
Abstract: The bottom part for shoes consists of a resistant hard material, for example of wood, hard plastic, hard leather or ceramic. This bottom part 1 consists of a plurality of individual parts 2, 3, 4, 5, 6, 24. These individual parts 2, 3, 4, 5, 6, 24 are connected to one another in a hinge-like manner along seams 7, 8, 9, 10, 25. The seams 7, 8, 9, 10, 25 delimited by the successive individual parts 2, 3, 4, 5, 6, 24 lie transversely to the longitudinal direction of the bottom part 1 and in the region of lines 11, 12, 13, 14, 28 which connect the foot skeleton joints provided transversely over the foot. Five seams running transversely to the longitudinal direction of the bottom part 1 are provided. The first three seams 7, 8, 9, as seen from the front side or toe side of the bottom part 1, run arcuately and, if appropriate, the penultimate seam 10 runs in a wave-like manner. The centres of curvature of the three seams 7, 8, 9 running arcuately are all located on the same side of these seams 7, 8, 9. The individual parts 2, 3, 4 serving for supporting the front of the foot are additionally subdivided by seams 17, 18, 19, 20 running essentially longitudinally. The longitudinal zones delimited by these seams 17, 18, 19, 20 running longitudinally correspond to the number of middle foot bones of a human foot. <IMAGE>
Patent AT-408820-B (AT)
Title: Data transmission outlet kit
IPC: H01R13/58
Filed: 1998-05-07
Granted: 2002-03-25
Abstract: Data transmission outlet kit for an electrical connection between a transmission cable 64 and an external plug connector, having a connection module with strain relief means 20 for clamping the cable, having a small housing box 16 and having a cover 18 which can be fixed firmly to the small housing box, with the cover having bearing means 42, which interact with bearing means 34 for the strain relief means, in order to hold the strain relief means provisionally in a correct position in the vicinity of the cable, such that the strain relief means can then be applied to this cable in order in this way to firmly clamp the cable between the strain relief means and a wall of the small housing box, for which purpose the provisional bearing means have pins 42 which project from the cover such that they can be inserted into pin bearing holes 34 in the strain relief means. <IMAGE>
Patent DK-162349-B (DK)
Inventor: HVARRE JOHN NIKOLAJ
IPC: C02F1/48
Filed: 1989-02-16
Abstract: A coffee and/or tea machine (1) has an upper water container (2) which serves to receive the amount of fresh water necessary for the brewing, and downwardly has at least one outlet opening (5) leading to a lower water container (3) where, in operation, the water is heated by means of e.g. an electric heating member (8). With a view to softening the water a ring (13) of a magnetizable ceramic material is placed on the bottom (4) of the upper water container (2) in axial alignment with an outlet opening (5) in said bottom. During the passage to the lower water container (3) the water is then subjected to the action from the highly concentrated magnetic field of the central opening of the ring so that the water is softened and already formed lime deposits are loosened.
Patent HU-195680-B (HU)
Inventor: EVERETT PETER K
IPC: C25C7/08
Filed: 1983-12-09
Abstract: Die Erfindung betrifft eine Elektrolytzelle zur Gewinnung eines Metalls aus einem Erz oder Konzentrat, die billig und lange haltbar ist, und einen hohen Wirkungsgrad besitzt. Die Anoden und Kathoden sind radial zueinander angeordnet und es sind Organe zum Erhitzen des Schlammes und/oder des Elektrolyten, zum Entfernen des Metalls von den Kathoden und zum Erzeugen eines Turbulenzflusses des Schlammes an der Oberflaeche wenigstens einer Anode vorgesehen.
Patent HU-200129-B (HU)
Title: Fibre-reinforced material structure with thermoplastic fibres
Inventor: PEDERSEN KURT B
IPC: D01F8/06
Filed: 1984-02-13
Abstract: For reinforcing of forming materials of the cold setting type such as concrete or various cross linking plastic materials, solid or foamed, is provided a thermoplastic fibre material, the fibres of which have a surface layer of mineral particles which are partly and only partly embedded in the thermoplastic fibre material, to which the particles are firmly weld bonded, such that the exposed outer particle surfaces are firmly bondable to the forming material. Hereby the mineral particles will form a rigid connection between the forming material and a central fibre core or layer of high tensile strength, whereby the thermoplastic fibres are effectively surface bonded to the forming material so as to show a high reinforcing effect.
Patent HU-186657-B (HU)
Title: Electrode holder for electric arc furnaces
Inventor: ELTNER GUENTER
IPC: H05B7/103
Filed: 1983-02-18
Abstract: The invention relates to an electrode mount for electric arc furnaces for receiving and holding the electrodes and for transmitting the electric energy from the electrode mount to the electrode. It is the object of the invention to provide an electrode mount which combines in an optimum way the advantages of the material steel with respect to its mechanical properties and those of the material copper with respect to its electrical conductivity. According to the invention, this has been achieved by making the electrode bearing surface and the current terminal face on a conventionally cooled basic steel body from a combination of explosion-plated steel and copper materials. The thickness of the copper layer is up to 10 mm. The electrical resistivities of the copper layer relative to the copper/steel transition zone are as 2:1. An unalloyed mild steel is used in the copper/steel material combination. A partition which positively guides the coolant flow is arranged in the interior of the basic steel body for the purpose of intensive heat dissipation. <IMAGE>
Patent HU-196868-B (HU)
Inventor: POHARNOK PAL
IPC: A01B15/04
Filed: 1987-02-26
Abstract: A találmány szántóvas gyorsszántó ekékhez amelynek éllel rendelkező szelvénye és orr-része van. A találmány lényege, hogy a szelvény munkafclülcténck elméleti egyenes síkja (4) hátoldallal (5) 4—9’-os szöget (a) zár be és a valós munkafelület (5) az elméleti egyenes síkhoz (4) képest befelé dőlően mintegy 0—5°-os szögben (β) van kialakítva és ezek a szögek elméleti 2—5 mm élszalag vastagsághoz (7) vannak rendelve, az él azonban 10—20'-os élszöggel 0,5—1 mm szélességűre van lemunkálva.  -1-
Patent SE-306100-B (SE)
Inventor: DERSCH W
IPC: H03K3/315
Filed: 1963-01-14
Abstract: 1,025,441. Semi-conductor circuits. INTERNATIONAL BUSINESS MACHINES CORPORATION. Jan. 2, 1963 [Jan. 15, 1962], No. 246/63. Heading H3T. [Also in Division G4] A switching circuit, e.g. for producing sharp pulses comprises two tunnel diodes X 10 , X 2o . Fig. 2, having series load resistors R 1 , R 2  respectively, connected in parallel across a supply: resistor R 1  is smaller than R 2 , so that more current flows through diode X 10  than diode X 20 . Increasing the current supplied causes diode X 10  to trigger to its high resistance state increasing the current through diode X 20 , and producing the leading edge of the output pulse E out , Fig. 3, after the inherant delay time of a tunnel diode, diode X 20  switches its state producing the trailing edge of the pulse E out . A backward diode B.D. may be connected in the output circuit to present positive overshoot at the end of the pulse. In a second embodiment, Fig. 4, a number of tunnel diodes Xa ... Xe are connected to form a sequential register resistor Ra1 is of lower value than the others, so that its first triggering pulse switches diode Xa to its high resistance condition, but leaves the others unchanged. The change in resistance of diode Xa increases the standing bias on diodes Xb so that the next triggering pulse will switch this diode and increase the bias on Xc ready for the third pulse, and so on until all diodes are switched. The " sequencing " property may be employed in a word recognition circuit, Fig. 6. Detectors of strong frictioning Fs voicing V and weak frictioning Fw are connected to word recognition blocks each of which comprise tunnel diode registers of the type described above. The circuit of Fig. 4 may be modified to form a counter, Fig. 7 (not shown) by connecting all the trigger inputs to a common pulse source so that each pulse to be counted changes the state of one diode. The circuit of Fig. 2 may be used as the source of pulses for such a counter.
Patent RS-50273-B (RS)
Inventor: NADEL A JAY
IPC: A61K48/00
Filed: 1999-08-17
Abstract: Upotreba antagonista receptora epidermalnog faktora rasta (EFG-R) za proizvodnju leka za lečenje hronične opstruktivne bolesti pluća (COPD), pri čemu je dati agonist EGF-R , inhibitor tirozin kinaze selektivan za EGF-R, antitelo koje specifično vezuje EGF-R, ili antisens molekul specifičan za kodirajuću sekvencu za EGF ili EGF-R.Prijava sadrži još 9 zavisnih patentnih zahteva.
Patent YU-45710-B (YU)
Inventor: SCHER H B
IPC: A01N25/28
Filed: 1985-03-29
Abstract: Novel microcapsules are disclosed in which a liquid material which is substantially insoluble in water is enclosed within a solid permeable shell of etherified urea-formaldehyde polymer, prepared by a process which comprises: (a) providing an organic solution comprising said material and a urea-formaldehyde prepolymer in which from about 50% to about 98% of the methylol groups of said prepolymer have been etherified with a C4-C10 alcohol; (b) creating an emulsion of said organic solution in an aqueous solution comprising water and a surface-active agent, wherein said emulsion comprises discrete droplets of said organic solution dispersed in said aqueous solution; (c) causing in situ self-condensation of said urea-formaldehyde prepolymers by adding to said emulsion an acidifying agent and maintaining said emulsion at a pH of between about 0 and about 4 for a sufficient period of time to allow substantial completion of in sttu condensation of said resin prepolymers to convert the liquid droplets of said organic solution to capsules consisting of solid permeable polymer shells enclosing said liquid material; and (d) heating said emulsion to a temperature between about 20 DEG C and about 100 DEG C to cause curing of said in situ formed polymers.