baber/WOPTO huggingface dataset:
Patent CA-2584368-A1 (CA)
Title: Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
Inventor: ASHWELL MARK
IPC: C07D519/00
Filed: 2005-10-19
Abstract: An efficient route for the synthesis of formula (I), of imidazooxazole and imidazothiazole inhibitors of the p38 MAP kinase pathway, useful as therapeutics for disease conditions including inflammation and auto-immune responses is described.
Patent CA-2586174-A1 (CA)
Title: Methods of preparing indazole compounds
Inventor: PERRY MICHAEL DAVID
IPC: A61K31/416
Filed: 2005-10-21
Abstract: The present invention relates to methods for preparing indazole compounds of formula I, which are useful as modulators and/or inhibitors of protein kinases. (I).The present invention also relates to intermediate compounds useful in the preparation of compounds of formula I.
Patent CA-2587272-A1 (CA)
Inventor: CHUNG WING YEUNG
IPC: H04N7/18
Filed: 2005-11-03
Abstract: An imaging system (5) for generating landmark correlated images taken from a railroad locomotive includes a camera (142) mounted on the locomotive (22) for imaging an environment in a vicinity of the locomotive and transmitting imaging data indicative of images acquired. The system also includes a location sensor (20) on board~the locomotive generating signals indicative of a geographic location of the locomotive constituting location data. The system also includes a railroad landmark database (68) comprising a plurality of railroad landmarks (76) associated with respective geographic locations constituting landmark tags. The system also includes a processor (e.g., 10) receiving the imaging data and location data and communicating with the railroad landmark database to correlate the landmark tags with the imaging data and the location data for generating landmark correlated image data. The system may also include a computer system (86) for accessing the landmark correlated image data by landmark location.
Patent CA-2589722-A1 (CA)
Title: Measuring the movement characteristics of an object
Inventor: MOONEY BRIAN FRANCIS
IPC: A63B69/36
Filed: 2005-12-06
Abstract: A method of an apparatus for measuring or determining the movement characteristics of an object uses the detection of changes in beams. A set of beams F1 - B1, F2 - B2, F3 - B3 is disposed in the movement path of the object; at relative angles to each other; and at acute angles to the intended direction of the object. The number of changes in the beams or durations between changes in the beams are recorded. The relative times, durations or differences in relative times, at which different beams of the set are changed are measured. The resulting measurements are associated with the relevant movement characteristics of the object.
Patent CA-2589866-A1 (CA)
Title: Infrared radiation absorbing sun protection film
Inventor: DANZEBRINK ANNE
IPC: G02B5/22
Filed: 2005-11-28
Abstract: The invention relates to a coloured sun protection film for transparent or translucent panes, comprising at least one metallised and/or unmetallisied carrier film and at least one functional layer.
Patent CA-2590923-A1 (CA)
Title: Modulation de niveaux d'azote dans des plantes
Inventor: SCHNEEBERGER RICHARD
IPC: A23L33/00
Filed: 2005-12-02
Abstract: L'invention concerne des procédés et des matériaux permettant de moduler (par exemple, augmenter ou diminuer) les niveaux d'azote dans des plantes. L'invention concerne, par exemple, des acides nucléiques codant pour des polypeptides qui modulent l'azote ainsi que des procédés permettant d'utiliser ces acides nucléiques pour transformer des cellules végétales. L'invention concerne également des plantes et des produits végétaux présentant une augmentation des niveaux d'azote.
Patent CA-2594878-A1 (CA)
Title: Indoles useful in the treatment of inflammation
Inventor: OLOFSSON KRISTOFER
IPC: C07D405/12
Filed: 2005-12-22
Abstract: There is provided compounds of formula (I), Wherein X1 , R1 , R2 , R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.
Patent CA-2595112-A1 (CA)
Inventor: SESHASAYEE DHAYA
IPC: C07K16/28
Filed: 2005-12-23
Abstract: The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
Patent CA-2598459-A1 (CA)
Title: Novel heterocyclic substituted pyridine or phenyl compounds with cxcr3 antagonist activity
Inventor: MCGUINNESS BRIAN F
IPC: C07D413/14
Filed: 2006-02-14
Abstract: The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1 or a pharmaceutically acceptable salt, solvate or ester thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, zenograft rejection), infectious diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
Patent CA-2600321-A1 (CA)
Title: Lightweight low permeation piston-in-sleeve accumulator
Inventor: MOSKALIK ANDREW J
IPC: F16L55/04
Filed: 2006-03-06
Abstract: A lightweight, low permeation, piston-in-sleeve high-pressure accumulator is provided. The accumulator includes a cylindrical composite pressure vessel with two integral rounded ends. A piston slidably disposed in a thin nonpermeable internal sleeve in the accumulator separates two chambers, one adapted for containing a working fluid and the other adapted for containing gas under pressure. Working fluid is provided in a volume between the nonpermeable internal sleeve and the composite pressure vessel wall. Further means are provided for withstanding harmful effects of radial flexing of the composite vessel wall under high pressures, and from stresses present in use in mobile applications such as with a hydraulic power system for a hydraulic hybrid motor vehicle. A method for pre-charging the device is also presented.
Patent CA-2600582-A1 (CA)
Title: Fixing system for at least one fluidic component of a chromatography device
Inventor: SCHLODERER RICHARD
IPC: F16B2/06
Filed: 2006-02-17
Abstract: The invention relates to a fixing system for at least one fluidic component (4) of a chromatography device, in particular for fixing said fluidic component(s) (4) in a column oven. According to the invention, the system is equipped with at least one brace (2), on which at least one fixing element (3) is detachably fixed in the desired position within a fixing region (2e) of the brace (2) by means of a friction or positive fit. The brace or braces (2) is or are fixed in a predetermined position by means of one or more support elements (1) and the fixing element or elements (3) is or are configured to receive and fix the fluidic component(s) (4). The invention also relates to a fixing element for a fixing system of this type, in which a first section (31) of the fixing element (3) is connected to a second section (33) of the fixing element (3) in such a way that the fluidic component (4) that is to be held and fixed is retained between two clamping areas of the first (31) and second (33) sections in a friction or positive fit.
Patent CA-2601556-A1 (CA)
Title: Portable railcar step and railcar therewith
Inventor: BARBARA JONATHAN A
IPC: B61D23/00
Filed: 2007-09-12
Abstract: A railcar step mounts to the stirrup of a rail vehicle. The railcar step comprises a support sized to support a rail worker. A coupling is supported in relation to an end of the support. The coupling is sized and configured to hold the support in fixed relation to the stirrup. The support is sized to extend outward beyond the rail vehicle and support a rail worker.
Patent CA-2603462-A1 (CA)
Title: Phospholipid-based pharmaceutical formulations and methods for producing and using same
Inventor: MANSFIELD ROBERT K
IPC: A61K35/00
Filed: 2006-04-07
Abstract: Pharmaceutical formulations and methods of producing and using the same are described and claimed. The formulations are dispersions of phospholipids and one or more pharmacologically active compounds, pharmaceutically acceptable salts thereof, or prodrugs thereof. In specific embodiments, the pharmaceutically active compounds are ansamycins and the overall formulation is substantially devoid of medium and long chain triglycerides.
Patent CA-2607044-A1 (CA)
Inventor: LANGSETMO PAROBOK INGRID
IPC: A61P9/04
Filed: 2006-05-05
Abstract: The present invention relates to methods and agents for treating impaired vascular and cardiac function. Methods and agents for treating various physiological and pathological features associated with vascular dysfunction and cardiac dysfunction are also provided.
Patent CA-2607532-A1 (CA)
Title: Amplification and cloning of single dna molecules using rolling circle amplification
Inventor: HUTCHISON CLYDE A III
IPC: C12Q1/68
Filed: 2006-05-01
Abstract: The present invention relates, e.g., to a method for amplifying a small number of copies (e.g. a single copy) of a single-stranded circular DNA molecule (e.g. having a size of about 5-6 kb) by an isothermal rolling circle mechanism, using random or partially random primers and a .PHI.29-type (.PHI.29-type) DNA polymerase. The method, which can also be used for amplifying DNAs by non-rolling types of multiple displacement amplification, comprises incubating the reaction components in a small volume, e.g.  about 10 µL or less, such as about 0.6 µL or less. The degree of amplification can be about 109-fold, or higher. A method for cell-free cloning of DNA, using the rolling circle amplification method of the invention, is described.
Patent CA-2608198-A1 (CA)
Inventor: GITLER AARON D
IPC: A61K38/00
Filed: 2006-05-12
Abstract: Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha- synuclein mediated toxicity.
Patent CA-2611479-A1 (CA)
Inventor: VAN DIJK LISELOTTE
IPC: F16L11/20
Filed: 2006-05-31
Abstract: The invention relates to a flexible cryogenic transfer hose (7) for connecting two cryogenic facilities, the hose in use extending in a marine environment and having a length of at least 20 m, preferably at least 100 m. The hose comprises: an inner hose (10) with at least two segments (12,13), the inner hose segments being interconnected via at least two inner connecting members (16,17; 30a,30b;72,73) extending in a transverse direction, the inner hose being flexible and comprising a flexible reinforced wall having an internal diameter of at least 10 cm, - an outer hose (11) surrounding the inner hose and comprising a watertight elastomeric or composite material, the outer hose comprising at least two segments (20,21) which are mutually connected via two outer connecting members (24,25), the outer hose having a wall thickness of at least 2 cm, a bend radius of at least 2 m, and an internal diameter of at least 20 cm, - the inner hose being kept at a distance from the outer hose via a number of spacer elements (28,29) bridging a distance hi between the outer wall of the inner hose and an inner wall of the outer hose, which distance is between 0.1 and 0.8 times the internal diameter d10 of the inner hose (10), wherein a longitudinal position of a pair of inner connecting members (16,17;  30a,30b;72,73) is situated at or near a longitudinal position of a pair of outer connecting members (24,25). The inner connecting members (16,17;  30a,30b;72,73) bridge the distance hi between the inner and outer hose walls and comprise a flange section (16,17,72,73) of the inner hose wall, two transverse abutment surfaces (34,35) on the outer hose wall, the flange sections (16,17,72,73) being releasably engaged between the abutment surfaces (34,35) for preventing relative axial movement between the inner and outer segments (12,13; 20,21) at or near the longitudinal position of the pair of outer and inner connecting members, wherein the flange sections (72,73) are releasable from the inner hose wall and/or wherein the abutment surfaces (34,35) are releasable from the outer hose wall such that upon removal of the flange sections (72,73) and/or the abutment surfaces () from the gap between the inner hose (10) and outer hose (11) all wall parts of the inner hose (10) are at a distance from the wall of the outer hose (11).
Patent CA-2618617-A1 (CA)
Inventor: HONMA TOSHIHIKO
IPC: G02B6/25
Filed: 2008-01-21
Abstract: An optical fiber cutting device is configured so that a disk-like blade member is moved in a state, in which the blade member is pushed against a glass fiber part of an optical fiber, to form a flaw on a surface of the glass fiber part. The blade member is turned by a feed roller in synchronization with a movement operation of the blade member that rotates by a contact friction force generated when the blade member is put into contact with a contact member fixedly provided halfway a movement path of the blade member.
Patent CA-2619888-A1 (CA)
Title: Holder device for dental x-ray digital sensor
Inventor: BROWN KIMBERLY C
IPC: A61B6/14
Filed: 2006-11-16
Abstract: A sensor holder includes a frame member that bounds a void area and which is configured to receive a sensor. A retaining means is provided to hold the sensor to the frame such that a connecting cable affixed to the sensor is secured and positioned by the void area for a subsequent imaging procedure .
Patent CA-2622944-A1 (CA)
Inventor: VON HIRSCHHEYDT THOMAS
IPC: A61K31/506
Filed: 2006-09-28
Abstract: Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
Patent CA-2624407-A1 (CA)
Title: Submerged arc narrow gap welding with oscillating electrode
Inventor: GUNZELMANN KARL-HEINZ
IPC: B23K9/095
Filed: 2006-06-22
Abstract: The present invention discloses a method for submerged-arc narrow-gap welding, in which the wire electrode (30) is set in oscillating motion in the gap (10) in order to produce a first bead (50), the arc (40) moving backwards and forwards between one of the workpiece edges (20a, 20b) and a middle section (12) of the gap (10) so that the first bead (50) does not extend from the first (20a) to the second workpiece edge (20b).
Patent CA-2625264-A1 (CA)
Inventor: FULMER MARK THOMAS
IPC: A61N1/30
Filed: 2006-10-12
Abstract: A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material, hi one embodiment, the sleeve may be made in least in part from caprolactone to add stretchability to the sleeve.
Patent CA-2625369-A1 (CA)
Title: Accelerating device
Inventor: HOSAKA SHIRO
IPC: B64F1/10
Filed: 2006-10-06
Abstract: [PROBLEMS] An acceleration device capable of safely and efficiently accelerating an aircraft even it is a high-speed and heavy-weight one. [MEANS  FOR SOLVING PROBLEMS] The acceleration device has a support base for supporting an aircraft so that it does not go back, does not lift up, and does not perform pitching; a guide way placed along a predetermined route; a guide means for guiding the support base along the guide way; and a drive means for driving the support base along the guide way.
Patent CA-2625377-A1 (CA)
Inventor: JIN WU
IPC: B65D83/16
Filed: 2006-10-13
Abstract: A spraying device for spraying fragrance, pest control composition and/or a sanitising composition held within a pressurised container, the spraying device comprising a container receiving section (13) and a switching section (10) wherein the switching section (10) incorporates a solenoid switch.
Patent CA-2627621-A1 (CA)
Inventor: EL GEDAILY AHMED
IPC: C12P21/02
Filed: 2006-10-25
Abstract: The present invention relates to a method for concentrating and/or purifying prion PrPSc proteins by contacting prion PrPSc proteins with sepharose under conditions that allow for the specific and high affinity binding of the sepharose to the prion PrPSc proteins and removing the unbound non-prion proteins from the sepharose, as well as the same method for removing prion PrPSc proteins from body fluids by contacting body fluids with sepharose under conditions that allow for the specific and high affinity binding of the sepharose to the prion PrPSc proteins and removing the body fluid from said sepharose. In addition, the present invention is directed to a method for separating and/or enriching prion PrPSc proteins from PrPC proteins by contacting prion PrPSc proteins and PrPC proteins with a ligand-modified sepharose under conditions that allow for the specific and high affinity binding of the sepharose part to the prion PrPSc proteins and the binding of the ligand part of the sepharose to PrPC proteins, adding a selective release agent to the sepharose-bound proteins under conditions that allow for the release of non-prion proteins and PrPC proteins from the ligand part of the sepharose but not for the release of the prion PrPSc proteins, and removing the non-prion proteins and PrPC from the sepharose. Another aspect of the present invention concerns the use of the before-mentioned methods for concentrating, purifying and/or removing prion PrPSc proteins.
Patent CA-2631039-A1 (CA)
Title: Complexes multimeres d'antigenes et adjuvant
Inventor: HILL FERGAL
IPC: C07K14/445
Filed: 2006-11-29
Abstract: L'invention concerne un produit comprenant un domaine C4bp d'origine non mammifère, et notamment SEQ ID NO:1, SEQ ID NO:23 ou SEQ ID NO:37, ou un variant correspondant, et un antigène. Le produit se présente de préférence sous la forme d'une protéine hybride. L'invention concerne également le domaine C4bp aviaire de SEQ ID NO:1 et SEQ ID NO:23. Les antigènes comprennent des antigènes monomères tels que des antigènes paludéens et grippaux. Le domaine C4bp permet l'assemblage de complexes multimères de l'antigène, ou de mélanges correspondants. Ces complexes sont utiles comme vaccins.
Patent CA-2632457-A1 (CA)
Inventor: BOSC DENIS
IPC: C12M1/36
Filed: 2006-11-07
Abstract: The present invention relates to methods and processes for controlling fermentation. Two proportional feedback control loops are implemented in a cascade. One control loop is used to maintain the pH by adjusting the dissolved oxygen-stat setpoint. The other control loop is used to maintain the dissolved oxygen by regulating the nutrient feed rate using the newly adjusted dissolved oxygen-set point.
Patent CA-2638210-A1 (CA)
Title: Protection system
Inventor: LIST HANS-JOERG
IPC: B64D25/115
Filed: 2008-07-22
Abstract: The protection system is used especially for the protection against a fatal effect of verti-cal accelerations triggered by a landmine on the passengers of an armoured vehicle. For this, the sitting unit consisting of a seat body (7) and a backrest (8) is held movable in vertical direction and is coupled with an end area (15) of a longitudinally variable damp-ing device (11), whose other end (13) is connected to the roof (4) of the vehicle (2) through a carrying equipment (6). In addition, the sitting unit is carried with vertical dis-tance from the vertical guide (18) in a lower guide path (19) transversally directed so that the sitting unit executes both a downward as well as a tilting movement relative to the vehicle together with a passenger (3) during loading through vertical acceleration. In this way, an improved usage of the constructively limited effective length of the damping de-vice (11) occurs so that the effect of the protection system is essentially improved. It is sensible to apply the same principle for the protection of all objects, which must be pro-tected against the reaching or exceeding of a maximum load due to a too large accelera-tion or deceleration.
Patent CA-2640768-A1 (CA)
Inventor: TUERLER ANDREAS
IPC: G21G4/08
Filed: 2007-02-19
Abstract: A method for purifying 225>Ac (I) from irradiated 226>Ra (II) targets involves eluting all the (I) and (II) with acid, separating (I) from (II) and other radium isotopes by extraction chromatography using a solid support coated with N,N-dialkylamidomethyl-diorganophosphine oxide in a trialkyl phosphate, and then separating (I) from 210>Po and 210>Pb by extraction chromatography on a solid support coated with optionally substituted bis-cyclohexano-18-crown-6 in a 4-12C alkanol.. A method (M1) for purifying 225>Ac from irradiated 226>Ra targets (made on a support) involves (a) eluting the target with nitric or hydrochloric acid under reflux to remove all the 225>Ac and 226>Ra, (b) removing the HCl (if used) and redissolving the material in nitric acid, (c) concentrating the extract, (d) separating the 225>Ac from 226>Ra and other radium isotopes by extraction chromatography using a solid support coated with an extraction system comprising compound(s) of formula (I) in compound(s) of formula (II), (e) eluting the retained 225>Ac from the stationary phase with dilute nitric or hydrochloric acid ( 226>Ra is eluted in stage (d)), (f) separating the 225>Ac from 210>Po and 210>Pb by extraction chromatography using a solid support coated with an extraction system comprising compound(s) of formula (III) in compound(s) of formula R 10>-OH (IV), (g) using 2M-HCl as mobile phase and (h) recovering 225>Ac from the eluate, the 210>Po and 210>Pb being retained on the solid support. R1, R2 : octyl, n-octyl, phenyl or (1-3C alkyl)-substituted phenyl; R3, R4 : n- or iso-propyl, or n- or iso-butyl; R5-R7 : 2-5C alkyl, preferably n- or iso-butyl; R8, R9 : H, 1-5C alkyl or tert.-butyl; R10 : 4-12C alkyl. Independent claims are included for (1) a method (M2) for purifying 225>Ac as above, in which the solid support in stage (d) is coated with compound(s) of formula (IA) and stage (e) involves elution with 0.3-0.01M nitric acid or 1-0.05M hydrochloric acid (2) a method (M3) as above in which the support in (d) is coated with compound(s) of formula (IB) and stage (e) involves elution with 0.02-0.1M nitric acid (3) pharmaceutically-acceptable radionuclide compositions containing 225>Ac and obtained by the above methods. R1a-R4a : octyl or 2-ethylhexyl. ACTIVITY : Cytostatic. No biological data given. MECHANISM OF ACTION : None given.