baber/WOPTO huggingface dataset:
Patent EA-003064-B1 (EA)
Title: Effervescent laxatives
Inventor: DAGGY BRUCE P
IPC: A61K47/34
Filed: 2000-02-22
Abstract: 1. A pharmaceutical formulation comprising an osmotic amount of polyethylene glycol (PEG) 3350, or PEG 4000, and a pharmaceutically acceptable effervescent coupling system. 2. The formulation according to Claim 1 wherein the effervescent couple comprises about 10 to about 30% of the total weight of the formulation. 3. The formulation according to Claim 1 wherein the effervescent couple comprises an acid component selected from citric acid, tartaric acid, adipic acid, fumaric acid, malic acid, or acid salts thereof, or mixtures thereof. 4. The formulation according to Claim 1 wherein the effervescent couple comprises an alkaline component selected from sodium, potassium or calcium (bi) carbonates or sodium glycine carbonate. 5. The formulation according to any one of Claims 1 to 4 which further comprises one or more flavoring, colouring or sweetening agents. 6. The formulation according to Claim 1 wherein the PEG is present in an amount of 7.5 to 30 grams per unit dose. 7. The formulation according to Claim 1 wherein the PEG is present in an amount of 10 to 20 grams per unit dose. 8. A method of treating constipation in a mammal in need thereof, which method comprises administering to said mammal an effective amount of a formulation according to any of claims 1 to 7. 9. A method of treating fecal impaction in a mammal in need thereof, which method comprises administering to said mammal an effective amount of a formulation according to any of claims 1 to 7. 10. A formulation according to any one of claims 1 to 6 wherein the formulation is in a unit dose sachet.
Patent EA-006842-B1 (EA)
Title: Method of controlling zoological and aquatic plant growth
Inventor: CUTLER HORACE
IPC: A61K31/12
Filed: 2001-02-16
Abstract: A method of controlling target aquatic microorganism pest populations by exposing the target population to an effective amount of an aquacidal compound. The aquacidal compounds are selected from the group consisting of quinones, anthraquinones, naphthalenediones. The method is particularly effective for treating ballast water of ships or other enclosed volumes of water subject to transport between or among geographic areas to control the relocation of plants, toxic bacteria, and animals contained in the water.
Patent EA-004874-B1 (EA)
Title: NOVEL beta CRYSTALLINE FORM OF PERINDOPRIL TERT-BUTYLAMINE SALT, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
Inventor: PFEIFFER BRUNO
IPC: C07K1/30
Filed: 2001-07-06
Abstract: 1. A beta crystalline form of the compound of formula (I): characterised by the following X-ray diffraction pattern on powder measured using a diffractometer (copper anticathode) and expressed in terms: interplanar distance d, angle 2 theta Bragg's, intensity and relative intensity (expressed in % from the most intensive beam): Angle 2 Theta ( degree )	Inter-Planar distance	Intensity	Relative intensity (%) 5.169	17.08	523	16.5 8.379	10.54	1001	31.5 9.350	9.45	3175	100 14.746	6.00	236	7.4 15.411	5.74	753	23.7 15.931	5.56	279	8.8 16.711	5.30	113	3.6 18.161	4.88	122	3.8 20.564	4.32	1198	37.7 21.285	4.17	330	10.4 21.781	4.08	317	10 22.632	3.93	190	6 23.308	3.81	133	4.2 23.797	3.74	427	13.4 24.276	3.66	118	3.7 25.190	3.53	92	2.9 25.924	3.43	251	7.9 26.646	3.34	250	7.9 27.620	3.23	96	3 2. A method for preparing beta crystalline form of the compound of formula (I) according to claim 1, characterized in that perindopril tert-butylamine salt solution is refluxed in dichloromethane, then the solution is cooled to 0 degree C and obtained solid is collected by filtration. 3. The method for preparing beta crystalline form of the compound of formula (I) according to claim 1, characterized in that perindopril tert-butylamine salt solution is refluxed in dichloromethane, then the solution is quickly cooled to 5 degree C and obtained solid is collected by filtration. 4. The method according to any one of claims 2 or 3, characterized in that the compound of formula (I) is obtained as described in Patent EP 0 308 341. 5. The method according to claim 2, characterized in that the concentration of the compound of formula (I) in dichloromethane is between 100 to 200 g/l. 6. The method according to claim 2, characterized in that the concentration of the compound of formula (I) in ethylacetate is between 70 to 90 g/l. 7. A pharmaceutical composition comprising as an active ingredient a compound according to claim 1 in combination with one or more pharmaceutically acceptable, inert, non-toxic vehicles. 8. The pharmaceutical composition according to claim 7 for use in preparing medicaments as conversion enzyme angiotensine I inhibitors. 9. The pharmaceutical composition according to claim 8 for use in preparing medicaments for treating cardiovascular diseases. 10. The pharmaceutical composition according to any one of claims 7-9, characterized in that further comprising diuretic. 11. The pharmaceutical composition according to claim 10, characterized in that the diuretic is indapamide.
Patent EA-005304-B1 (EA)
Title: Engine generator
IPC: F02B57/08
Filed: 2001-03-28
Abstract: 1. A unitary engine generator, comprising: an internal combustion engine incorporating a rotatably driven central rotor supporting plural radially extending, arcuately spaced cylinders rotatable with said rotor about a central longitudinal axis; a piston moveable coaxially within each of said cylinders; a stationary unitary housing encasing said engine coaxially of said axis; a pair of registeringly aligned, like, axially spaced endless cam tracks formed integrally with opposing interior walls of said housing; a pair of cam followers associated with each said piston; each cam follower operationally engaging an adjacent one of said cam tracks; means in bearing relation with the exterior of each of said cylinders for interjoining a related pair of said cam followers and a respectively associated piston whereby combustion actuation of each piston serves to drive said cam followers along said cam tracks; a stationary field winding fastened to the interior periphery of said housing, concentrically surrounding said rotor and cylinders; and at least one magnetic mass mounted for movement with said rotor to generate electrical energy in response to orbital movement of said mass past said field winding. 2. The engine/generator of Claim 1, wherein said engine is a two cycle, multiple cylinder, rotary piston engine operable to fire each cylinder multiple times during each revolution, characterized by only two directional reversals of each piston per combustion sequence. 3. The engine/generator of Claim 1, wherein said engine is a two-cycle type, comprising a single poppet-type valve per cylinder which controls exhaust, purge and cooling cycles while preventing the escape of unconsumed fuel from each cylinder into the atmosphere. 4. The engine/generator of Claim 1, wherein said cam tracks are disposed in registering diametrically opposed relationship on opposite sides of said cylinders for controlling operational movements of said pistons. 5. The engine/generator of Claim 4, wherein each cam track is formed as part of a single endless cam defining a 360 rotational rotor orbit; each said cam defining plural symmetrical sections of said orbit with respect to said axis and each of said sections defining plural asymmetrical portions of said orbit with respect to said axis. 6. The engine/generator of Claim 1, wherein said cam tracks are configured to provide variable piston combustion strokes to optimize combustion of selected fuels. 7. The engine/generator of Claim 2, wherein said cam tracks of said engine are designed to provide a prolonged dwell period at the top and bottom of each piston's stroke, whereby each said piston is substantially stationary relative to its associated cylinder during both dwell periods.
Patent EA-007224-B1 (EA)
Title: 3-substituted-4-pyrimidone derivatives
Inventor: UEHARA FUMIAKI
IPC: A61P35/00
Filed: 2002-09-20
Abstract: A pyrimidone derivative represented by formula I or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1:wherein Rrepresents a C-Calkyl group which may be substituted; R represents, for example, a group represented by the following formula II: wherein Rand Rindependently represent a hydrogen atom or a C-Calkyl group; Rrepresents a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, and having 5 to 10 ring-constituting atoms in total.
Patent EA-007655-B1 (EA)
Title: Aminoindane derivatives as serotonin reuptake and norepinephrine uptake inhibitors
Inventor: BOGESO KLAUS PETER
IPC: A61K31/135
Filed: 2002-12-18
Abstract: The present invention relates to aminoindane derivatives having the formula I wherein X, Y, U, R, Rand R are as defined in the claims, or acid addition salts thereof. The compounds of the invention posses the combined effect of serotonin reuptake inhibition and norepinephrine uptake inhibition.
Patent EA-009952-B1 (EA)
Title: Game management system
Inventor: FUJIMOTO JUN
IPC: A63F5/04
Filed: 2006-03-10
Abstract: When an insurant of the game insurance attempts to play a game on another gaming machine after having played a game on one gaming machine, the member inputs and transmits information to the effect of playing a game being covered by the game insurance on another gaming machine, on condition that the insurant of the game insurance has been identified, thereby halting making of a determination as to whether or not insurance coverage of the game insurance has been paid. Subsequently, the insurant of insurance who has played a game on another gaming machine inputs and transmits information to the effect of not playing a game being covered by the game insurance on another gaming machine, thereby canceling a halt of making a determination as to whether or not insurance coverage of the game insurance is paid.
Patent EA-014165-B1 (EA)
Title: Pneumococcal polysaccharide conjugate vaccine
Inventor: BIEMANS RALPH LEON
IPC: A61K39/09
Filed: 2006-12-20
Abstract: The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided with various conjugated capsular saccharides from different S. pneumoniae serotypes conjugated to 2 or more different carrier proteins, where the composition comprises serotype 19F capsular saccharide conjugated to diphtheria toxoid (DT) or CRM197, optionally wherein 19F is the only saccharide in the composition conjugated to diphtheria toxoid (DT) or CRM197.
Patent EA-017915-B1 (EA)
Title: Kcnq-openers of potassium channels used for treating or reducing the symptoms of schizophrenia
Inventor: HUSUM BAK-JENSEN HENRIETTE
IPC: A61K31/136
Filed: 2007-02-02
Abstract: The present invention relates to the use of a selective KCNQ potassium channel opener for the preparation of a pharmaceutical composition for treating or reducing the symtoms of schizophrenia and related symptoms, disorders and diseases. Furthermore the invention relates to the use of a compound for the preparation of a pharmaceutical composition for treating or reducing the symtoms of schizophrenia, where the compound is selected from the group consisting of N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester; 2-cyclopentyl-N-(2,6-dimethyl-4-morpholin-4-ylphenyl)acetamide; N-(2,6-dimethyl-4-morpholin-4-ylphenyl)-3,3-dimethylbutyramide; N-(4,6-dimethyl-2-morpholin-4-ylpyrimidin-5-yl)-2-(4-fluorophenyl)acetamide; hexanoic acid (2,6-difiuoro-4-morpholin-4-ylphenyl)amide; 2-cyclopentyl-N-(4,6-dimethyl-2-morpholin-4-ylpyrimidin-5-yl)acetamide; N-(2-bromo-4-morpholin-4-yl-6-trifluoromethylphenyl)propionamide; N-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-3,3-dimethylbutyramide; [2-amino-4-(2,4,6-trimethylbenzylamino)phenyl]carbamic acid ethyl ester; and 2-cyclopentyl-N-(2-methoxy-6-methyl-4-morpholin-4-ylphenyl)acetamide or a pharmaceutically acceptable salt thereof.
Patent EA-014848-B1 (EA)
Title: Method for controlling injection rate of high pressure fuel pump and device therefor
Inventor: KERIMOV ZIJAFAT HEIRULLA OGLY
IPC: F02M41/14
Filed: 2008-11-07
Abstract: The invention relates to machinery engineering, in particular, to engine engineering. The invention is aimed at enhancing power density and efficiency of a diesel engine operation, reducing smokiness and toxicity of exhaust gases by improving characteristics of fuel injection and also making simpler a method of controlling fuel injection rate and a device therefor. The inventive task is characterized in that controlling fuel injection rate is carried out by decreasing partly space of injection cavity emptied by a metering plunger at an injection stroke of an injecting plunger, wherein the space is partially emptied by the metering plunger effected by fuel pressure in the injection cavity and the value of emptied space is measured by displacement of the metering plunger stroke limiter. Besides, a device for controlling injection rate of a high-pressure fuel pump is provided with a metering plunger capable to reciprocating motion in a cylindrical seat pressed by a spring arranged in the cylindrical seat to one of its ends, wherein at the other end of the cylindrical seat the metering plunger stroke limiter is arranged therein capable for displacement along the axis of the metering plunger, wherein the space of the cylindrical seat and the stroke limiter thereof is connected via a channel to a low-pressure system, and the opposite end of the cylindrical seat space to which the metering plunger is pressed by a spring is connected to an injection pump space.
Patent EA-016317-B1 (EA)
Title: Device and method for water removal in distillation columns
Inventor: MAK JOHN
IPC: C02F1/24
Filed: 2008-08-28
Abstract: Water is removed from oily water produced during operation of a separation column by withdrawing the oily water from the column during separation into an external separator where the oily water is separated into a water phase and an oily phase. The oily phase is then heated to a temperature effective to produce a density differential that drives the oily phase back into the operating column.
Patent EA-027205-B1 (EA)
Title: Device for dosing an additive solution
Inventor: BAKKENES HENDRIKUS WILHELMUS
IPC: B05D1/30
Filed: 2012-12-03
Abstract: The claimed invention relates to a device (1) for dosing an aqueous solution (2) of an additive into an amount of a particulate material. The device comprises a conveyor (4) for transporting the particulate material and one or more dispensers (5) arranged above the conveyor. The dispensers are connected to a supply for the aqueous solution of the additive, wherein the dispenser comprises at least one pouring outlet (10) extending over the width of the conveyor section transporting the particulate material. The claimed invention also relates to a method for dosing an aqueous solution (2) of an additive into a particulate material (3) by means of a device for dosing an aqueous solution, the method comprising pouring the aqueous solution under the influence of gravity with a controlled flow velocity over the width of a conveyor (4) transporting the particulate material.
Patent EA-027990-B1 (EA)
Title: Substituted (2r,3r,5r)-3-hydroxy-(5-pyrimidin-1-yl)tetrahydrofuran-2-ylmethyl aryl phosphoramidates
Inventor: IVASHCHENKO ANDREY ALEXANDROVICH
IPC: C07F9/6596
Filed: 2014-10-06
Abstract: The present invention relates to novel substituted esters of amido-phosphoric acid - (2R,3R,5R)-3-hydroxy-(5-pyrimidin-1-yl)tetrahydrofuran-2-ylmethyl aryl phosphoramidate of general formula 1, or a stereoisomer, or a pharmaceutically acceptable salt thereof:where Rrepresents hydrogen, (CH)[(CH)C]Si, C-Cacyl, optionally substituted by an NRRgroup, in which Rand Rrepresent, independently, hydrogen or a C-Calkyl; 1-pyrrol-2-ylcarbonyl, piperidin-3-ylcarbonyl or piperidin-4-ylcarbonyl; Rand Rrepresent F; or Rrepresents F or OH, and Rrepresents CH; Rrepresents hydrogen or methyl; Ar represents phenyl, pyridyl or naphthyl, where phenyl, pyridyl or naphthyl are optionally substituted by at least one of the following: Calkyl, Calkenyl, Calkynyl, Calkoxy, F, Cl, Br, I, nitro, cyano, -N(Calkyl); Pm represents 2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl or 4-amino-2-oxo-2H-pyrimidin-1-yl, in which the amino group is optionally substituted by the radical C(O)R, where Rrepresents (1) C-Calkyl, optionally substituted by an NRRgroup, where Rand Rrepresent, independently, hydrogen or C-Calkyl; Calkoxy, optionally substituted by phenyl; (2) 1-pyrrol-2-ylcarbonyl, piperidin-3-ylcarbonyl, piperidin-4-ylcarbonyl; X represents O or N-R, where Rrepresents C-Calkyl, optionally substituted by OH or OCH; n=1, 2 or 3. The novel compound can be used as a hepatitis C virus NS5B polymerase inhibitor, and for treating a disease caused by the hepatitis C virus.
Patent EA-031785-B1 (EA)
Title: Mould for a clippable bottle
Inventor: BOU-MEZRAG MOHAMMED SEIFFEDDINE
IPC: B29C49/54
Filed: 2015-05-18
Abstract: The present invention relates to a base (200) for a mould, for a clippable bottle, comprising, on the upper face (201) thereof, a wall (202) for moulding the bottom of the container to be produced, from which a head (204) extends along a longitudinal axis A2, said head (204) comprising a peripheral surface (205) comprising at least one blind opening (207), characterised in that the portion (208) of said peripheral surface (205) in line with said blind opening (207) can move between a forward position, wherein said portion is aligned with the rest of said peripheral surface (205), and a rear position, wherein said portion (207) is set back from the axis parallel to the axis A2 and passing through the bottom of said blind opening (207).
Patent EA-035786-B1 (EA)
Title: Method of preparing a ferment based on symbiotic culture of rice fungus
Inventor: SHINGAREVA TATYANA IVANOVNA
IPC: A23C9/12
Filed: 2017-07-20
Abstract: The invention relates to dairy industry and can be used to produce fermented dairy products. The ferment is produced by introducing Oryzamyces indici rice fungus culture in proportion of 1:30 by weight into skimmed milk prepared for souring, which has been pasteurized in advance at 93-95C during 20-30 min, then the milk is agitated and soured to form a curd with an initial ferment being produced; the produced initial ferment is introduced into slimmed milk prepared for souring in a proportion of 1:5 to 1:10 and soured to form a curd with a primary ferment being produced, then the produced primary ferment is introduced into skimmed milk prepared for souring in an amount of 105% and soured to form a curd with a final product being produced, wherein said phases of milk souring are performed at a temperature of 25-28C. The proposed method allows producing a rice fungus ferment with a dense, homogenous curd and pronounced sour milk taste and smell, reducing the period of souring, and increasing the mass of the rice fungus culture.
Patent EA-032788-B1 (EA)
Title: Scanning drive circuit
Inventor: XIAO JUNCHENG
IPC: G02F1/13
Filed: 2014-12-09
Abstract: A scanning drive circuit (20) is provided. The scanning drive circuit (20) comprises a pull-up control module (21), a pull-up module (22), a pull-down module (23), a pull-down maintaining module (24), a bootstrap capacitor and a constant-voltage low level source; and wherein the pull-up control module (21) is respectively connected with the pull-up module (22), the pull-down module (23), the pull-down maintaining module (24) and the bootstrap capacitor, and wherein the constant-voltage low level source is respectively connected with the pull-down maintaining module (24) and the pull-down module (23). The scanning drive circuit (20) is provided with the pull-up control module (21), so that the phenomenon of power leakage can be neatly avoided, and the reliability of the scanning drive circuit (20) is improved.
Patent EA-037174-B1 (EA)
Title: Method for preparation of flux based on secondary aluminum-containing slag
Inventor: NEMENENOK BOLESLAV MECHESLAVOVICH
IPC: C22B9/10
Filed: 2018-07-24
Abstract: The invention relates to the field of iron and steel industry, to processing of secondary aluminum-containing slag, and can be used for production of various steel grades. The technical result is achieved when using the invention as involving the newly formed waste of salt aluminum-containing slag into production processes for flux preparation in iron and steel industry, at the expense of slag dumps removal. The essence of this invention is expressed as a new set of features in the method of flux preparation for ladle DE oxidation of steelmaking slag based on secondary aluminum-containing slag, including metallic acid-soluble aluminum, aluminum oxide, potassium and sodium oxides, silicon and ferric oxides. According to the invention, the above-listed components for flux are preliminarily hydrated to obtain water-soluble aluminates and water-soluble alkalis; water-soluble chlorides and alkalis are leached out by washing with water; high-temperature drying is carried out at 400-500°C to remove crystallization water associated in oxides to reach a humidity of 1.5% as maximum; then cooling, crushing and grading into grain size are carried out; magnesium oxide and lime (CaO) as a calcinated dolomite are further added to the dried and graded flux product; prior to packing, barium-strontium carbonate BSK-2 is added according to the grain size, to the dried and graded flux product in the amount of 1.0 to 15 wt.%.
Patent EA-035462-B1 (EA)
Title: Cellulose ethers with temporary cross-links, a process to make them, and their use
Inventor: KARLSSON HANS JONAS
IPC: C08L1/26
Filed: 2016-10-13
Abstract: The invention relates to temporary cross-linked cellulose ethers, a process to make them, as well as their use to influence the rheological profile of an aqueous medium in which they are dissolved. The temporary cross-linked cellulose ethers are characterized in that they are cellulose ethers that are cross-linked with at least one or more compounds of the formula (Calkyl)-OC(O)CHOHO-(Calkyl).
Patent EA-036402-B1 (EA)
Title: Threaded connection including an intermediate shoulder
Inventor: DALY DALY
IPC: E21B17/042
Filed: 2016-12-05
Abstract: A threaded tubular connection comprises a first tubular component and a second tubular component. The first tubular component includes a female portion defined on an interior surface of the first tubular component. The female portion includes an inner threaded portion and an outer threaded portion which are offset radially with respect to a longitudinal axis of the first tubular component by a first shoulder. The second tubular component includes a male portion defined on an exterior surface of the second tubular component. The male portion is to be inserted into the female portion, and includes an inner threaded portion and an outer threaded portion which are offset radially with respect to a longitudinal axis of the second tubular component by a second shoulder. The second shoulder is to abut the first shoulder once the male portion is connected to the female portion.
Patent EA-038288-B1 (EA)
Title: Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
Inventor: FALKNER FALKO-GUENTER
IPC: C12N15/86
Filed: 2016-11-11
Abstract: The invention provides, among other aspects, codon-altered polynucleotides encoding Factor VIII variants for expression in mammalian cells. In some embodiments, the invention also provides mammalian gene therapy vectors and methods for treating hemophilia A.