baber/WOPTO huggingface dataset:
Patent AT-411267-B (AT)
Title: Iron alloy containing carbon, silicon, manganese, chromium and nickel is used as a material for products having a high ballistic protective action
Inventor: SAIGER HORST
IPC: C22C38/24
Filed: 2001-12-19
Granted: 2003-11-25
Abstract: Use of an alloy containing (in wt.%): 0.3-0.6 C, 0.08-0.59 Si, 0.1-0.6 Mn, 0.9-1.5 Cr, 2.4-5.5 Ni and a balance of Fe as a material for products having a high ballistic protective action is new. The alloy contains P and S in a sum of less than 0.025 wt.% and the sum of Mo and W does not exceed 0.38. Mo is less than 0.28, W less than 0.29 and Mo + W/2 less than 0.38. The sum of the impurity elements As, Sb, Bi, Sn, Zn and B is less than 0.011.  Preferred Features: The alloy contains additions of (in wt.%): 0.36-0.54, preferably 0.41-0.49 C, 0.11-0.39 Si, 0.18-0.49, preferably 0.25-0.38 Mn, 1.15-1.4 Cr and 2.9-4.9, preferably 2.56-3.9.
Patent AT-410516-B (AT)
Title: Method and device for fire-fighting in a dust separator
IPC: A62C3/04
Filed: 2000-12-05
Granted: 2003-05-26
Abstract: A method and a device for fire-fighting in a dust separator (1) are described, which has a crude gas shaft (2) with filter elements (5) attached to a pure gas shaft (4), whereby an extinguishing agent is blown into the crude gas shaft (2) by means of a compressed inert gas. To create advantageous conditions it is proposed that an extinguishing fluid in the form of a liquid mist is sprayed into the crude gas shaft (2) with the aid of the inert gas.
Patent CN-1638925-B (CN)
Title: 一种折叠工具
Inventor: STAN MOIZIS
IPC: B26B1/04
Filed: 2002-11-15
Granted: 2010-05-05
Abstract: 一种折叠工具(10)，譬如刀或多用工具，具有一个由相对的侧壁(16和18)限定的柄(12)，侧壁间有一狭槽(36)。将器具譬如刀片(14)枢轴地连接到柄(12)。弹簧譬如衬垫(22)具有切割于其中的纵向狭槽(70)和在邻近器具装配的端限定弹簧臂(80)的开口，衬垫(22)设置在所述器具和一个侧壁之间。所述狭槽包括一个收缩区域，该收缩区域优选地为V形，并具有一个与所述器具的枢轴轴线对齐的顶点。所述器具上的销(53)在狭槽中移动。当所述销处在顶点的后侧时，弹簧臂施加压力到器具，防止它移到打开位置。因此将器具安全地和可靠地锁在所述柄里。当旋转器具以至销移到所述顶点的前侧上，经过极限点时，弹簧臂返回到其静止位置，赋予所述器具销压力和能量，因而帮助打开，将器具移到完全打开位置。提供锁紧装置(50)以将器具可靠地锁在打开位置以待使用。
Patent CN-1674935-B (CN)
Title: 含有CpG或寡/多核苷酸以及毒素或肠毒素的双功能组合物
Inventor: JAN HOLMGREN
IPC: A61P37/02
Filed: 2003-06-05
Granted: 2011-03-02
Abstract: 描述了一种双功能组合物，它包含细胞内有效的免疫调节核酸成分，所述核酸成分含有至少一种免疫刺激，免疫抑制或免疫调节基序，并且是选自具有天然磷酸二酯骨架或被修饰骨架的单核苷酸，二核苷酸，寡核苷酸或多核苷酸，所述核酸成分任选地与特定的抗原组合，与在哺乳动物细胞表面结合于特异性受体的蛋白质结合，所述蛋白质可选自霍乱毒素(CT)，CT亚单位B(CTB)，大肠杆菌热不稳定性肠毒素(LT)，LT亚单位B(LTB)，以及可以与CT或LT的抗血清反应的，结合于GM1神经节苷酯的，ADP-核糖基化受体蛋白的，或者引起靶细胞内环AMP积累的蛋白质或蛋白质衍生物，以及在与特异性细胞表面成分结合之后可被内在化进入细胞的抗体其它蛋白质。这种组合物可用于治疗肿瘤、感染、移植排斥，免疫抑制状态，自身免疫性疾病和过敏症，并且伴有特定抗原时可进一步用于免疫预防，免疫治疗或耐受性诱导，以及用于在体外处理抗原提呈细胞，随后输注进入哺乳动物体内，达到疫苗接种或免疫治疗的目的。
Patent CN-1013039-B (CN)
Inventor: SHIHUA WANG
IPC: C07F7/22
Filed: 1987-07-06
Abstract: 一种制备高纯晶体三苯基氢氧化锡的方法，该方法用聚乙二醇及其衍生物作催化剂及C 1 ～C 6 正构或异构烃的醇作抑制剂，因而不但使反应能在水溶液中顺利进行并能有效地抑制歧化反应：高收率(99%以上)，高纯度(几乎100%)地获得三苯基氢氧化锡产品。与目前所采用技术比，本发明的方法使用的抑制剂和催化剂廉价且用量少，反应后产物易分离同时反应收率和纯度高。
Patent FI-128441-B (FI)
Title: Fatty acid composition
Inventor: LINDQVIST PETRI
IPC: C11C3/12
Filed: 2015-02-09
Granted: 2020-05-15
Abstract: This invention relates to the field of renewable oil compositions and especially to the use of renewable oil compositions for production of hydrocarbon compositions, which can be used for traffic fuels and other solutions. Especially, the current invention relates to a composition comprising free fatty acids and triglycerides, in a concentration of free fatty acids from 15 wt-% to 35 wt-% and the rest being predominantly triglycerides. The invention relates also to a method for producing hydrocarbons from a renewable oil feedstock, in which the feedstock comprising free fatty acids from about 15 wt-% to about 35 wt-%, and the rest being predominantly triglycerides is subjected to a pre-treatment process followed by a hydrotreatment process for obtaining hydrocarbons.
Patent FI-129545-B (FI)
Title: Modelling a vessel and its vicinity in real-time
Inventor: ELORANTA SAULI
IPC: G06K9/00
Filed: 2017-01-25
Granted: 2022-04-14
Abstract: According to an aspect, there is provided a method and an apparatus for modelling a vessel and its vicinity real-time. The method comprises obtaining (102) static data (200) comprising three-dimensional model data of the vessel, map data relating to the location of the vessel and data relating to the surroundings of the vessel, obtaining (104) non-sensed dynamic data (202) relating to the surroundings of the vessel, obtaining (106) dynamic sensor data (204) comprising data from at least one onboard sensor of the vessel and/or data from at least one external entity providing dynamic sensor data for the vessel, and combining (108) based on the static data (200), non-sensed dynamic data (202) and dynamic sensor data (204) a real-time three-dimensional navigation model (206) providing a three-dimensional view of the vessel and its vicinity.
Patent FI-129948-B (FI)
Title: Substrate processing apparatus and method
Inventor: KILPI VÄINÖ
IPC: H05B3/00
Filed: 2021-05-10
Granted: 2022-11-15
Abstract: Substraatin käsittelylaitteisto (10), joka käsittää: reaktiokammion (11), ulomman kammion (15) joka ainakin osittain ympäröi reaktiokammiota (11) ja missä reaktiokammion (11) ja ulomman kammion (15) väliin on muodostunut välitila (40), ainakin yhden lämmityselementin (30), ainakin yhden välitilassa (40) olevan lämmönjakajan (20), ja ainakin yhden ulomassa kammiossa (15) olevan lämmityselementin läpiviennin (37) joka sallii ainakin yhden lämmityselementin (30) läpikulun välitilaan (40) ainakin osittain ja yhteenkytkeytymisen ainakin yhden lämmönjakajan (20) kanssa.
Patent HK-1056179-B (HK)
Title: Oxidation process for preparing the intermediate 6.alpha., 9.alpha.-difluoro-11.beta., 17.alpha.-dihydroxy-16.alpha.-methyl-androst-1,4-dien-3-one 17.beta.-carboxylic acid
Inventor: ALBINSON FREDERICK DAVID
IPC: C07J31/00
Filed: 2003-09-17
Abstract: The present invention relates to a process for the preparation of a compound of formula (I) which comprises the following step: wherein step (a) comprises oxidation of a solution containing the compound of formula (II) wherein the solution is formed in a mixture of water and tetrahydrofuran.
Patent HU-177424-B (HU)
Title: Process for preparing carbazole derivatives with antidepressive activity
Inventor: FLIENDER LEONARD J
IPC: A61P25/24
Filed: 1979-03-16
Abstract: 2-Amino- and 2-(substituted amino)-tetrahydro- and -cis-hexahydro-carbazoles, useful for alleviating depression in mammals and intermediate compounds thereto.
Patent HU-177426-B (HU)
Title: Nonskid shoe for vehicle wheels
Inventor: HYGGEN EGIL
IPC: B60C27/00
Filed: 1977-03-31
Abstract: An improved gripping member for gripping shoes used on vehicle wheels is disclosed. The cross sectional shape of the gripping member is formed as a U throughout its length whereby substantially improved traction and a substantially stronger gripping member are obtained. In a preferred embodiment, the side legs of the U-shaped gripping member are made wavy in the area which contacts the ground.
Patent IT-1274813-B (IT)
Title: Axial piston pump in open circuit with a double delivery
Inventor: PARESCHI SANZIO
IPC: F01C/
Filed: 1994-06-30
Granted: 1997-07-25
Abstract: Axial piston pump in open circuit with a double delivery of the type comprising a rotating drum in which are provided a plurality of axial cylinders corresponding with corresponding slots made in one of the ends of the drum and located about a circumference which can slide against the surface of a fixed plate having aspiration and delivery openings consistent with the fact that the said plate has one aspiration opening and two delivery openings which are distributed along a single circumference, with the aspiration opening affecting a half circumference and the delivery openings affecting the other half circumference, the lengths of the said openings being such as to determine the ratio between the flows of the two deliveries. <IMAGE>
Patent IT-1259427-B (IT)
Title: Orthopaedic shoe
Inventor: GIONTELLA MASSIMO
IPC: A61F/
Filed: 1992-01-24
Granted: 1996-03-18
Abstract: Orthopaedic shoe with a flat sole 2 and a plantar insole 3 provided with a silicone insert 1 fixed between sole 2 and plantar insole 3 which extends from heel 7 towards the toe of the shoe over the entire plantar arch of the foot, this insert comprising in the vicinity of heel 7 a sector 8 inset in the heel and with a flat upper base in which an annular cavity 4 is provided and is open at the top to produce an inner yielding body 5 supporting the heel bone 9 and comprising in the median part of the sole two longitudinal projections 6, 60 located along the inner and outer sides of the shoe respectively to support the plantar arch. <IMAGE>
Patent IT-1247506-B (IT)
Title: Pharmaceutical composition containing a combination of 3,4-di-O-isobutyryl-epinine and isosorbide-5-mononitrate
Inventor: POZZI FRANCO
IPC: A61K/
Filed: 1991-04-19
Granted: 1994-12-17
Abstract: A pharmaceutical composition containing 3,4-di-O isobutyryl-epinine, isosorbide-5-mononitrate and β cyclodextrin in the following proportions by weight: 3,4- di-O-isobutyryl-epinine:isosorbide-5-mononitrate = from 10:1 to 5:1, β-cyclodextrin:3,4-di-O-isobutyryl epinine = from 1.6:1 to 0.8:1 is described.
Patent IT-1251163-B (IT)
Title: Dispositivo per la pulitura o la deumidificazione di materiale in nastro
Inventor: SCHWEIGER ERNST
IPC: G03C1/74
Filed: 1991-08-08
Granted: 1995-05-04
Abstract: L'invenzione concerne un dispositivo per la pulitura o la deumidificazione di materiale in nastro, in particolare per l'essiccamento di carta fotografica esposta, in cui il materiale in nastro viene fatto passare davanti ad un ugello di soffiatura da parte di un organo di guida. L'ugello di soffiatura e l'organo di guida di questo dispositivo sono installati con possibilità di spostamento l'uno rispetto all'altro.(Figura 2).
Patent IT-1258842-B (IT)
Title: Vibratory equipment for inducing muscular/tendon vibration for biomedical use
Inventor: ROVETTA ALBERTO
IPC: A61H/
Filed: 1992-01-31
Granted: 1996-02-29
Abstract: This invention relates to an innovative system for inducing muscular/tendon vibration for biomedical and rehabilitative use. The subject matter of this invention comprises a portable vibrating device which can be applied to a portion of the body for long periods. This can be applied to patients having neuromotor diseases in which facilitation of the nervous activation of some muscles and/or inhibition of the activity of other muscles in the context of dynamic and functional activities is required. The main feature of the invention is that of permitting facilitative and/or inhibitory effects on muscular activity which are more intense and longer lasting than those possible with conventional vibromassagers. Power supply Excitation Keyboard Screen <IMAGE>
Patent IT-1254868-B (IT)
Title: Dispositivo per l'interruzione selettiva temporizzata di utenze a gas e/o elettriche di un apparecchio di cottura
Inventor: DE MARTIN MATTIO ARRIGO
IPC: F24C15/10
Filed: 1992-04-15
Granted: 1995-10-11
Abstract: Un dispositivo per l'interruzione selettiva temporizzata di una pluralità d'utenze a gas o elettriche (A, B, C, D) di un apparecchio di cottura, utenze comandabili mediante rispettive manopole (1a, 1b, 1c, 1d) tramite corrispondenti alberi (2a, 2b, 2c, 2d), comprendente un temporizzatore (18), selettivamente collegabile meccanicamente, per mezzo di un commutatore (19), ad un dispositivo di scatto (5) associato a ciascun'utenza (A, B, C, D).
Patent IT-1255312-B (IT)
Title: Dispositivo per il molleggio di assali rigidi di autoveicoli.
IPC: B60G11/113
Filed: 1992-05-06
Granted: 1995-10-31
Abstract: Per realizzare un dispositivo per il molleggio di assali rigidi di roulotte, costituito da un pacchetto di molle e balestra, una staffa per molla, che circonda il pacchetto di molle a balestra nel centro della sua estensione longitudinale nonchè l'assale del veicolo, e da una piastra del giogo fissata su di esso nonchè da un perno che penetra centralmente attraverso il pacco di molle a balestra e che con una sua estremità è fissata alla piastra del giogo, mentre l'altra estremità presenta una testa del perno che appoggia sulla molla più in basso del pacco di molle a balestra ed è accoppiato in una cavità a foro cieco di un supporto di cuscinetto dell'assale rispettivamente dello chassis del veicolo, per mezzo del quale dispositivo sia possibile effettuare in maniera semplice un successivo rinforzo del pacchetto di molle a balestra, si propone che tra il supporto di cuscinetto (8) e la molla (6), che è la più corta del pacchetto (1) di molle a balestra ed è vicino a questo sia inserita un'altra molla a balestra, che è poco più corta della molla a balestra (11) più lunga munita di occhi di molla (10), che alle estremità dell'altra molla a balestra (9) siano disposti dei blocchetti distanziatori (12) sporgenti verso le altre molle, la cui altezza è almeno quasi uguale allo spessore degli strati di molle, che sono più corti dell'altra molla a balestra (9) misurata tra i blocchi distanziatori (12).
Patent IT-1255190-B (IT)
Title: Dispositivo di interfaccia di comando per un motore elettrico
Inventor: MARCHISI GIUSEPPE
IPC: H02K23/66
Filed: 1992-06-30
Granted: 1995-10-20
Abstract: Il dispositivo di interfaccia di comando per un motore elettrico, particolarmente un motore elettrico per l'azionamento di servomeccanismi a bordo di un veicolo, comprende un telaietto conduttore, un componente attivo integrato montato sul telaietto conduttore, ed una pluralità di connettori elettrici. Un unico corpoinvolucro isolante monolitico racchiude il telaietto conduttore con il componente attivo integrato ed i connettori elettrici, compresi nel telaietto conduttore.In questo modo tutti gli elementi necessari per l'alimentazione ed il controllo del motore sono racchiusi in un unico corpo-involucro, che può essere manipolato e collegato facilmente.
Patent IT-1255853-B (IT)
Inventor: CHIODINI GRAZIELLA
IPC: C08K5/3462
Filed: 1992-10-12
Granted: 1995-11-17
Abstract: Ionically curing of VDF-containing fluoroelastomers selected from the ones containing less than 60 moles % of VDF and from the ones containing hydrogenated olefins is improved by using, as accelerators, triazinic compounds of formula: <CHEM> (R = H, C1-C4 alkyl; R' = R or benzyl, arylalkyl; X = Cl, Br, I, a bisphenoxy radical or O-CH2Rf-CH2R2; Rf = a perfluorooxyalkylene chain; R2 = -OH, -O<->). What is claimed are the fluoroelastomeric compositions containing said accelerators.
Patent IT-1256259-B (IT)
Title: Composti mettallocenici aventi leganti di tipo fluorenilico
Inventor: RESCONI LUIGI
IPC: C08F4/642
Filed: 1992-12-30
Granted: 1995-11-29
Abstract: META I LO CERI Di FORMU I A (I):METALLOCENI DI FORMULA (I): (FORMULA I) IN CUI I SOSTITUENTI R1 SONO, AD ESEMPIO, ATOMI DI IDROGENO O GRUPPI ALCHILICI, M E' Ti, Zr O Hf, I SOSTITUENTI R2 SONO, AD ESEMPIO, ALOGENI O GRUPPI ALCHILICI, IL GRUPPO R3 E', AD ESEMPIO, UN RADICALE DIALCHILSILANDILICO, SONO UTILI QUALI COMPONENTI CATALITICI PER LA POLIMERIZZAZIONE DI OLEFINE.
Patent IT-1273439-B (IT)
Title: Prosthesis comprising two parts for producing terminal anastomoses in vessels and ducts present in living organisms without sutures and without eversion of the vessel wall
Inventor: TOZZI PIERGIORGIO
IPC: A61F/
Filed: 1995-01-23
Granted: 1997-07-08
Abstract: This relates to a prosthesis which makes it possible to produce a terminal anastomosis in a vessel or duct without resorting to eversion of the vessel wall and without the need for stitches, which can also be applied to pathological vessels of any diameter. The prosthesis comprises two complementary separate parts (hemi prostheses) each of which are fixed to one of the two ends of the duct or vessel using an appropriate tool. The two hemi prostheses fixed in this way to two stubs of vessels are joined together by means of a nesting mechanism restoring the continuity of the vessel. The technical innovation introduced by this device is represented by the possibility of making terminal anastomoses in vessels and ducts in the course of video surgery which cannot otherwise be made. In addition to this, because of its easy applicability, this method makes it possible to reduce the time for the making of anastomoses, with particular advantage in emergencies, in the course of organ transplants and in the implantation of vascular prostheses currently in use. <IMAGE>
Patent IT-1261636-B (IT)
Title: Equipment for producing the hangers normally used to support false ceilings in buildings, laboratories, offices and various spaces
IPC: B21F/
Filed: 1992-06-22
Granted: 1996-05-23
Abstract: The equipment rationalises and speeds up the construction of the "hangers" normally used to support false ceilings in buildings, laboratories, offices, hospital, meeting or conference rooms, produced in old buildings or industrial sheds or areas with other originally intended uses. These hangers, which are no more than a steel wire of a certain length with one end bent into an eyelet and folded at 90 degrees, are made every day by hand on site or purchased ready made in standard lengths that can be adapted. The invention, designed in two versions, one with manual operation and the other motorised, both types portable although with different capabilities, ensures the finished product is of consistent quality, eliminating small but costly problems with installation which are almost always carried out under difficult conditions. <IMAGE>
Patent IT-1250468-B (IT)
Title: Giocattolo mobile a forma di autoveicolo.
Inventor: OZAWA AKIO
IPC: A63H31/08
Filed: 1991-08-23
Granted: 1995-04-07
Abstract: Viene messo a disposizione un giocattolo mobile a forma di autoveicolo.Un telaio 10 interno contiene un meccanismo di vibrazione e vibra verso destra e verso sinistra tramite il movimento dell'ingranaggio cilindrico 70 disposto tra due parti cilindriche 71 che ricevono la forza e che sono fissate al corpo esterno 2 del giocattolo mobile a forma di autoveicolo. Un meccanismo di cambiamento della direzione della potenza dirige la potenza trasmessa da un motore 20 al meccanismo di vibrazione per un tempo prefissato così da simulare il riscaldamento del motore dell'autoveicolo. Quindi, la potenza viene trasmessa al meccanismo di spostamento per consentire lo spostamento in avanti del giocattolo mobile a forma di autoveicolo.(FIG. 3)
Patent IT-1258408-B (IT)
Title: Dispositivo portatile per l'esecuzione di bordi su lastre di marmo, granito, travertino e simili.
IPC: B24B47/14
Filed: 1992-07-02
Granted: 1996-02-26
Abstract: Il dispositivo comprende un sistema di azionamento idraulico 1, con variazione dei giri 2, e conseguente assenza di corrente elettrica in fase operativa e un sistema di copiatura che consente di seguire il profilo del pezzo M comunque esso sia tagliato, regolabile poiché è necessario allontanare l'utensile U per un migliore utilizzo dello stesso.
Patent IT-1261826-B (IT)
Title: Composizioni di cera contenenti tensioattivi anfoteri, loro produzioneed impiego
Inventor: SCHLEUSENER ECKART
IPC: C09K23/00
Filed: 1993-07-14
Granted: 1996-06-03
Abstract: Composizioni cerose (P) contenenti tensioattivi anfoteri diluibili in acqua comprendenti in qualità di cera (W) una cera idrocarburica ossidata e facoltativamente parzialmente saponificata oppure un miscuglio di tali cere e, in qualità di tensioattivo (A1) almeno un tensioattivo anfotero che contiene una catena di etere del glicol polietilenico e facoltativamente ulteriori tensioattivi ed aggiunte, le quali composizioni sono eccellentemente convenienti in qualità di ammorbidenti con elevata idrofilità, e sono altamente compatibili con i brillantanti ottici e con le composizioni di finitura a base di resine sintetiche.
Patent IT-1245404-B (IT)
Title: Device for detection and warning of contact
Inventor: CADOSSI RUGGERO
IPC: G08B/
Filed: 1991-02-05
Granted: 1994-09-20
Abstract: The device 1 comprises a portable generator 7 of pre established signals provided with an output connected to a first transducer 8 which transmits such signals to the body of a first operator 3 (for example, a doctor, nurse, etc.) and means of processing 4 that analyze a signal from the second transducer 11 carried by a second operator 5 (for example, a patient, etc.) and which detect a significant presence of said pre-established signal, as a result, for example, of contact (direct or indirect) of the first operator 3 with the second operator 5. Figure 1 <IMAGE>
Patent IT-1259594-B (IT)
Title: Dispositivo di visualizzazione munito di un tubo a raggi catodici.
IPC: H01J29/76
Filed: 1992-06-22
Granted: 1996-03-20
Abstract: Dispositivo di visualizzazione con tubo a raggi catodici in cui un materiale a resistenza, per esempio grafite, è disposto su ciascuna di una parte a pannello, una parte a cono e una parte a collo di un tubo e raggi catodici, e un gruppo ad avvolgimenti di deflessione è montato sulla parte a collo attraverso un isolatore, per schermare il campo elettrico alternato generato dal gruppo di avvolgimento di deflessione.
Patent IT-1259831-B (IT)
Title: Device for automatically inserting corner pieces into the frame sections of glass cabinets
Inventor: BERTONCELLO ORIANO
IPC: E06B/
Filed: 1992-09-11
Granted: 1996-03-28
Abstract: The device to which the invention relates can be used to insert corner pieces 2 at the ends of sections 1 used to manufacture frames for glass cabinets. This device has means for continuously advancing the corner pieces in a position in which they are mutually alongside each other to bring them up against the hollow tubular section 1 into which the said corner pieces are inserted. Means of advance, immobilising and cutting the section in a transverse direction are provided, and a clamp 11 which is capable of lifting at least one corner piece at a time in order to fit it into the end of the tubular section is provided, the latter then being caused to advance by an amount equal to the length which it is to have, in order to be then cut by means of circular blade 5 (fig. 1). <IMAGE>
Patent MX-163101-B (MX)
Inventor: PLAQUIN BERNARD
IPC: E21B17/042
Filed: 1985-03-22
Abstract: The present invention concerns a new threaded joint for steel tubes, usable in particular in the petroleum industry, which contains a female element equipped with conical threads having an internal screw stop mating and a male element correspondingly threaded with a screw stop having a form corresponding to the female element. The male element stop and the female element stop are each manufactured by cold working using a tool capable of engaging in or on the threads of the corresponding element.
Patent PT-100011-B (PT)
Inventor: SCHEA HENRY E III
IPC: G01N1/42
Filed: 1992-01-14
Abstract: Disclosed are shipping and/or storage units for containers of liquid compositions, such as solutions of biologically active proteins, which are susceptible to physicochemical change upon freezing. Preferred container holders have double sidewalls and a freeze indicator adjacent a container-accommodating cavity. A phase change material such as a carboxymethylcellulose gel is disposed in the enclosed space between sidewalls and freezes at a temperature higher than the nucleation temperature of the composition. A freeze indicator provides an irreversible visual signal upon reaching a temperature intermediate the nucleation temperature of the liquid composition and the freezing temperature of the phase change material.