Patent SG-11201908396P-A (SG)
Title: Methods of treating tumor
Inventor: BHAGAVATHEESWARAN PRABHU SESHAIYER
IPC: C12Q1/68
Filed: 2018-03-30
Abstract: co00 O O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT (51) International Patent Classification: CO7K 16/28 (2006.01) A61K 39/395 (2006.01) C12Q 1/68 (2018.01) A61P 35/00 (2006.01) C12Q 1/6886 (2018.01) (21) International Application Number: PCT/US2018/025518 (22) International Filing Date: 30 March 2018 (30.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/479,817 31 March 2017 (31.03.2017) US 62/582,146 06 November 2017 (06.11.2017) US (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). (72) Inventors: BHAGAVATHEESWARAN, Prabhu Se- shaiyer; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). BOTWOOD, Nicholas Allan John; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). CHANG, Han; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). FU, Yali; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). GEESE, William J.; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). GREEN, George A., IV; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). HEALEY, Diane; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). MAIER, Sabine; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). NATHAN, Faith E.; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). OUKESSOU, Abderrahim; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). SELVAGGI, Giovanni; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). SZUSTAKOWSKI, Joseph Daniel; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). (74) Agent: KIM, Ji-Eun et al.; Sterne, Kessler, Goldstein & Fox P.L.L.C., 1100 New York Avenue, NW, Washington, District of Columbia 20005 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: METHODS OF TREATING TUMOR (57) : The disclosure provides a method for treating a subject afflicted with a tumor, lung cancer, having a high tumor e.g., mutation burden (TMB) status comprising administering to the subject an immunotherapy, an anti- PD-1 antibody or antigen-bind- e.g., ing portion thereof. The present disclosure also provides a method for identifying a subject suitable for an immunotherapy, e.g., a treatment with an anti-PD-1 antibody or antigen-binding portion thereof, comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids. ill~~~~~~~~ 011101010VIIIOH olo HE mil moi ono iflo oimIE (10) International Publication Number WO 2018/183928 Al