baber/WOPTO huggingface dataset:
Patent CA-2971901-A1 (CA)
Title: Improvements in oligodendroglial cell culturing methods and in methods for treating neurodegenerative disorders by using thyroid hormones or analogues
Inventor: PETRATOS STEVEN
IPC: C12N5/095
Filed: 2015-12-24
Abstract: The present invention relates to methods of treating or ameliorating certain neurodegenerative disorders (namely, dysmyelinating and demyelinating disorders) in patients in need of such treatment or amelioration. The invention provides methods of treating or ameliorating a patient in need of such treatment, comprising the administration to the patient of: (a) thyroid hormones or thyroid hormone analogues; (b) cell replacement therapies involving the use of homogenous Oligodendrocyte Precursor Cells derived from embryonic stem cells that have been treated with thyroid hormones or thyroid hormone analogues; (c) gene therapy to correct mutated genes in vivo; or (d) a combination of two or more of (a), (b) and (c). The invention also provides compositions and formulations of thyroid hormones and thyroid hormone analogues for use in treating or ameliorating such disorders.
Patent CA-2972835-A1 (CA)
Inventor: WANG YUQIANG
IPC: C07C241/00
Filed: 2015-08-11
Abstract: Disclosed are a trifluoroacethydrazide compound as well as preparation and application thereof. The compound has a structure represented by general formula (I). The compound has multiple mechanisms of action, comprising inhibition of glutamate excitotoxicity, activation of MEF2 transcriptional activity, and the effect of scavenging free radicals and promoting neural differentiation, and thus has a desirable protective effect on neurocytes and can alleviate memory impairment of a scopolamine-induced mouse model. The compound can be used for preparing a medicament having a cell protective effect, which is used for preventing or treating diseases related to glutamate excitotoxicity, MEF2 imbalance or overproduction of free radicals, e.g., diseases related to neurodegeneration comprising senile dementia, Parkinson's disease, cerebral stroke and the like, and diseases related to free radicals such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.
Patent CA-2973587-A1 (CA)
Inventor: HOSSEINI KHALIL
IPC: B28B7/42
Filed: 2017-07-17
Abstract: In a method and composition for manufacturing the products that made of cement, concrete and clay materials, it is known to freeze the materials before removing them from their molds. The freezing action is providing temporary hardness for the mixture of the materials to be protected against deforming during its removal from the mold. For protecting the properties of the composition in subfreezing temperatures and during the setting time in the freezer, use of additives product such as PolarSet is allowed. PolarSet allows the continuum chemical reaction within the frozen mixture while been kept in the freezer for hours in the early stage of hardening.
Patent CA-2974113-A1 (CA)
Title: Isoergoline compounds and uses thereof
Inventor: ARMER THOMAS
IPC: C07D457/12
Filed: 2016-01-20
Abstract: Provided herein are isoergoline compounds and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1A, 5-HT1Bm and 5-HT1D receptors without agonizing the 5-HT2B receptor using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the 5-HT2B adrenergic alpha2A and/or the alpha2B receptors using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the D2 and D3 receptor using the compounds and pharmaceutical compositions disclosed herein.
Patent CA-2974941-A1 (CA)
Title: Composition for treating inflammatory diseases induced by hyperimmune response
Inventor: CHOI HEONSIK
IPC: A61P37/06
Filed: 2016-02-05
Abstract: The present invention relates to a cell therapeutic agent for treating inflammatory diseases caused by hyper-immune responses and, more specifically, to a composition for treating inflammatory diseases caused by hyper-immune responses, containing: (i) cartilage cells or cells, which can be differentiated into cartilage cells; and (ii) cartilage cells into which a gene encoding TGF-ß is introduced or cells, which can be differentiated into cartilage cells into which a gene encoding TGF-ß is introduced.
Patent CA-2977902-A1 (CA)
Title: Locking device for locking a mechanism for an aircraft
Inventor: ZWIEBLER MARKUS
IPC: B64C25/26
Filed: 2017-08-31
Abstract: The invention relates to a locking device for locking a mechanism for an aircraft, with a lever and a hook, whereby the lever and the hook are pivotably arranged about two axes which are particularly spaced apart of each other, and whereby a spring element is disposed between the lever and the hook, and a lever gate and a roller are disposed on the lever and/or the hook for transmitting a torque between the lever and the hook.
Patent CA-2977905-A1 (CA)
Title: Derivatives of 2-aminopyridine as adenosine a2b receptor antagonists and ligands of the melatonin mt3 receptors
Inventor: CASTRO- PALOMINO LARIA JULIO CESAR
IPC: A61P11/08
Filed: 2016-02-19
Abstract: The present invention relates to pyridine derivatives of formula (I): (see formula I) as A2B adenosine receptor antagonists and ligands of MT3 melatonin receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by antagonizing the adenosine A2B  receptor and by inhibition of MT3 melatonin receptor, such as respiratory disease, metabolic disorders, neurological disorders and cancer.
Patent CA-2979162-A1 (CA)
Title: Foldable power strip
Inventor: IRBE TRISHA
IPC: H01R25/16
Filed: 2017-09-14
Abstract: A foldable power strip having a pair of housing members having one or more outlets thereon and being rotationally connected together about a hinge or vertical axis. A power cord housing is also connected about the hinge or vertical axis to permit the housing members and power cord to be independently rotated relative to one another. The inside walls of the housing members may include side members that define a recess for receiving and protecting the power cord when the housing members are in the closed position.
Patent CA-2979509-A1 (CA)
Title: Expansion anchor
Inventor: GSTACH PETER
IPC: F16B13/06
Filed: 2016-03-22
Abstract: The invention relates to an expansion anchor which can be fixed in a borehole, said anchor comprising an expansion sleeve for anchoring to a wall of the borehole and comprising an anchor bolt which is guided through the expansion sleeve and which has an expansion region to expand the expansion sleeve, wherein the expansion sleeve has a first annular groove on the outer face thereof, which groove extends to the front end face of the expansion sleeve that faces the expansion region. According to the invention, the expansion sleeve has a second annular groove on the outer face thereof, and an annular connection piece is arranged between the first annular groove and the second annual groove.
Patent CA-2979602-A1 (CA)
Inventor: BAKKER TALITHA
IPC: C07K14/765
Filed: 2016-04-01
Abstract: New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with binding specificity for hepatocyte growth factor (HGF), at least one designed ankyrin repeat domain with binding specificity for vascular endothelial growth factor (VEGF-A), and at least two designed ankyrin repeat domain with binding specificity for serum albumin are described, as well as nucleic acids encoding such designed ankyrin repeat domains and recombinant binding proteins, pharmaceutical compositions comprising such designed ankyrin repeat domains, recombinant binding proteins or nucleic acids and the use of such designed ankyrin repeat domains, recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.
Patent CA-2980800-A1 (CA)
Inventor: KELLEY RYAN
IPC: C07D417/04
Filed: 2016-04-22
Abstract: Disclosed embodiments of the formula below concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
Patent CA-2981611-A1 (CA)
Title: Process for upgrading asbestos tailings
Inventor: GUERARD MARC-AURELE
IPC: A62D3/40
Filed: 2015-04-13
Abstract: A process for upgrading a serpentine-containing material is provided. The process includes feeding the serpentine-containing material into a first reactor. The serpentine-containing material is pre-treated in the first reactor to obtain a pre-treated material. The pre-treating includes drying the serpentine-containing material, and removing dust particles from the serpentine-containing material. The process also includes feeding the pre-treated material into a second reactor; and dehydrating and calcining the pre-treated material in the second reactor to obtain a calcined material.
Patent CA-2981978-A1 (CA)
Title: Enhanced multi-layer cargo screening system, computer program product, and method of using the same
Inventor: Baldassari Tony
IPC: G06Q10/08
Filed: 2016-04-15
Abstract: Computer program products, methods, systems, apparatus, and computing entities for enhanced cargo screening capabilities are provided. In one embodiment, the method comprises: automatically and electronically executing a first screening procedure for capturing and storing first screening data comprising (a) an x-ray image and (b) first screening decontrol data; automatically and electronically determining whether at least a second screening procedure is required, the determination involving identifying at least one discrepancy between at least a portion of the first screening data and at least one predefined parameter; responsive to determining that the second screening is required, generating and transmitting one or more notifications configured to initiate the second screening procedure within a predetermined period of time; and responsive to determining that the at least second screening is not required, generating and transmitting a decontrol message configured to release the packages from further automated screening procedures.
Patent CA-2983195-A1 (CA)
Inventor: KARALL GERHARD
IPC: A41D13/015
Filed: 2016-04-22
Abstract: The present invention relates to a structure for absorbing and/or dissipating mechanical impacts, comprising: connectors forming a ventilated base having a base surface; and projections, each comprising a central axis along which the projection extends from the ventilated base, the central axis being normal to the base surface, two adjacent projections being connected to one another by a connector. The invention also relates to a body protector at least partially manufactured using the structure and a protective garment comprising at least one such protector.
Patent CA-2985072-A1 (CA)
Title: Electric vehicle charging circuit breaker
Inventor: ZHONG KEVIN
IPC: B60L50/16
Filed: 2017-11-09
Abstract: An electric vehicle charging circuit breaker for charging an electric vehicle with power from a power source. The electric vehicle charging circuit breaker includes a circuit protection unit structured to provide circuit protection between the power source and the electric vehicle, an electric vehicle charging unit structured to control charging of the electric vehicle, a metering unit structured to meter power flowing between the power source and the electric vehicle, and a display unit structured to display information including at least one of metering information and a status of electric vehicle charging.
Patent CA-2987334-A1 (CA)
Title: Method for determining a lifting angle and method for positioning a grinding mill
Inventor: PISCHTSCHAN MARTIN
IPC: B02C17/18
Filed: 2016-05-27
Abstract: The purpose of the invention to provide a method for determining a lifting angle of a charge inside a grinding mill at a specific point in time and a method for positioning a grinding mill which is more accurate. Method for determining a lifting angle (a) of a charge (2) inside a mill body (1) of a grinding mill being rotatable through a drive train, the method comprises the following steps of rotating the mill body (1); determining a reference lifting angle (aar) and a corresponding reference driving torque (Mr) of the drive train at a reference point in time; calculating a fill factor (K) for the reference point in time based on the reference lifting angle (ar) and the reference driving torque (Mr); determining a driving torque (M) of the drive train; and calculating the lifting angle (a) based on the driving torque (M) and the fill factor (K).
Patent CA-2988413-A1 (CA)
Inventor: REFSELL DAWN E
IPC: A01N43/58
Filed: 2016-05-26
Abstract: The present invention is directed to compositions containing a pigment synthesis inhibitor herbicide selected from the group consisting of a pyridazinone, isoxazolidinone, triketone, and isoxazole, and pyroxasulfone in a ratio of pigment synthesis inhibitor herbicide to pyroxasulfone of from about 1:0.3 to about 1:150. The present invention is further directed to methods of increasing the activity of a pigment synthesis inhibitor herbicide with the compositions of the present invention.
Patent CA-2989304-A1 (CA)
Title: Real-time control of diverters
Inventor: SUN ZHIJIE
IPC: E21B43/26
Filed: 2015-09-21
Abstract: In some aspects, the present disclosure includes systems and methods for determining and delivering diverting material to dominant fractures in a stage of a subterranean formation. The method includes creating or extending a plurality of fractures in a stage of a subterranean formation; pumping fracturing fluid to the plurality of fractures; identifying dominant fractures among the plurality of fractures; determining a desired amount of diverters to deliver to the dominant fractures; and pumping the determined amount of diverters to the dominant fractures so as to redistribute the flow of fracturing fluid between the plurality of fractures.
Patent CA-2992358-A1 (CA)
Title: Aircraft fire safety with oil pump deprime valve
Inventor: MANOUKIAN PATRICK
IPC: F16N29/02
Filed: 2018-01-18
Abstract: Herein provided are methods and systems for controlling operation of a deprime valve of an engine of an aircraft. A windmilling condition for an engine, indicative of at least one rotatable component of the engine being driven while the engine is inoperative, is detected. A fire event condition, indicative of a fire in proximity to the engine, is detected. When the windmilling and fire event conditions are detected concurrently, a command is sent to the deprime valve to cause the deprime valve to be open for a predetermined period of time.
Patent CA-2993659-A1 (CA)
Inventor: BEARSS DAVID J
IPC: A61K31/519
Filed: 2016-08-03
Abstract: L'invention concerne des thérapies combinatoires pour le traitement du cancer. Les méthodes selon l'invention comprennent l'administration d'un inhibiteur des kinases cycline-dépendantes et d'un inhibiteur des ADN méthyltransférases à un mammifère qui en a besoin.
Patent CA-2993710-A1 (CA)
Inventor: DAIS BRIAN C
IPC: B65D33/25
Filed: 2013-09-26
Abstract: A storage bag has first and second closure profiles adjacent to an opening to the interior of the bag. The first and second closure profiles are provided with dimples that are aligned opposite to each other. The dimples of the first closure profile are formed as a concave surface on the side of the first closure profile facing the interior of the bag and a convex surface on the side of the first closure profile facing the outside of the bag. The dimples of the second closure profile are formed as a convex surface on the side of the second closure profile facing the interior of the bag and a concave surface on the side of the second closure profile facing the outside of the bag. The dimples of the first closure profile are at least partially within the dimples of the second closure profile when the bag is being sealed.
Patent CA-3000585-A1 (CA)
Title: Carreau ceramique eclaire et procede de fabrication
Inventor: HAIDER ALEXANDER
IPC: F21V33/00
Filed: 2016-09-26
Abstract: Carreau céramique (1) comprenant une glaçure (11) recouvrant au moins la face d'aspect (10), une lumière générée par au moins une source lumineuse (6, 14) étant visible sur la face d'aspect (10); le corps du carreau céramique (1) est traversé par au moins un orifice (2) et/ou un évidement (22); la glaçure (11) est de conception photoconductrice et remplit de manière étanche au moins partiellement l'orifice (2) et/ou l'évidement (22); et ladite au moins une source lumineuse (6, 14) est disposée au dos du carreau céramique (1) et est en liaison photoconductrice avec l'orifice (2) et/ou l'évidement (22).
Patent CA-3000595-A1 (CA)
Title: Procede et systeme pour la presentation d'un etat de fonctionnement d'un moteur d'aeronef
Inventor: DANIELSON MICHAEL DWIGHT
IPC: G01D7/08
Filed: 2016-09-22
Abstract: L'invention concerne un procédé et un système pour présenter un état de fonctionnement d'un moteur d'aéronef. Le procédé comprend l'accès à une première indication qui indique une position d'un commutateur de démarrage de moteur d'aéronef et l'accès à une deuxième indication qui indique un mode de fonctionnement de démarrage du moteur d'aéronef, la deuxième indication ayant été générée en se basant sur une analyse d'un paramètre associé à une condition de fonctionnement du moteur d'aéronef. S'il est déterminé que la position du commutateur de démarrage de moteur d'aéronef est une position « marche » et que le mode de fonctionnement de démarrage du moteur d'aéronef est un démarrage conforme, le procédé provoque l'affichage d'une indication visuelle qui indique le démarrage conforme. S'il est déterminé que la position du commutateur de démarrage de moteur d'aéronef est une position « marche » et que le mode de fonctionnement de démarrage du moteur d'aéronef est un démarrage anormal, le procédé provoque l'affichage d'une indication visuelle qui indique le démarrage anormal.
Patent CA-3002920-A1 (CA)
Inventor: KADOTA KOHEI
IPC: C07D213/76
Filed: 2016-11-04
Abstract: In a method for producing a dedimethoxybenzylation compound that removes a dimethoxybenzyl group, in the presence of an acid, from a compound, in which the dimethoxybenzyl group is bonded to a nitrogen atom, a dedimethoxybenzylation compound is obtained by removing a dimethoxybenzyl group without producing a poorly soluble product from the removed dimethoxybenzyl group. The dedimethoxybenzylation reaction is carried out in the presence of triphenylphosphine or diethyl thiourea.
Patent CA-3003383-A1 (CA)
Title: Systeme de generation d'aerosol comprenant une entree d'air variable
Inventor: SILVESTRINI PATRICK CHARLES
IPC: A24F40/485
Filed: 2016-12-19
Abstract: L'invention concerne un système de génération d'aérosol comprenant une cartouche (2), la cartouche (2) comportant un premier compartiment (6) contenant une source de nicotine et un second compartiment (8) contenant une source d'acide. Le premier compartiment (6) comporte a une première entrée d'air (10) et une première sortie d'air (12), et le second compartiment (8) comporte une deuxième entrée d'air (14) et une deuxième sortie d'air (16). Le système de génération d'aérosol comprend en outre un embout (4) conçu pour s'enclencher avec la cartouche (2) afin de définir une chambre (26) en communication fluidique avec la première sortie d'air (12) et la deuxième sortie d'air (16).L'embout (4) comprend une troisième entrée d'air (32) en communication fluidique avec la chambre (26) et une troisième sortie d'air (27) en communication fluidique avec la chambre (26), le troisième entrée d'air (32) définissant une zone d'écoulement, et l'embout (2) étant conçu de sorte que la zone d'écoulement à travers la troisième entrée d'air (32) soit variable.
Patent CA-3004925-A1 (CA)
Inventor: HERNANDEZ CAMILO HENRIQUE LA ROTTA
IPC: C10L3/10
Filed: 2016-11-10
Abstract: The invention discloses a scavenger composition for use in eliminating and/or reducing hydrogen sulphide and/or mercaptans in a fluid, particularly for reducing or eliminating hydrogen sulphide from gases and liquids, including gaseous and liquid hydrocarbons, and sewer gases, and more especially from natural gas and liquid hydrocarbon streams. The composition makes use of a primary scavenging agent and a scavenging accelerator additive, which also acts as a precipitation inhibitor. The composition involves the use of a 1,3-dioxolane alkyl, alkenyl and/or hydroxyl derivative as primary scavenging agent, and accelerator additives based on ketones, including a-diketones, cyclic ketones, saturated ketones and/or a-unsaturated ketones.
Patent CA-3006663-A1 (CA)
Title: Propulsion system for an aircraft
Inventor: WAGNER NICHOLAS ADAM
IPC: B64D31/00
Filed: 2018-05-30
Abstract: A hybrid electric propulsion system includes a gas turbine engine and an electric machine coupled to the gas turbine engine. A method for operating the propulsion system includes determining, by one or more computing devices, a baseline power output for the gas turbine engine; operating, by the one or more computing devices, the gas turbine engine to provide the baseline power output; determining, by the one or more computing devices, a desired power output greater than or less than the baseline power output; and providing, by the one or more computing devices, power to, or extracting, by the one or more computing devices, power from, the gas turbine engine using the electric machine such that an effective power output of the gas turbine engine matches the determined desired power output.
Patent CA-3007811-A1 (CA)
Inventor: ENGEN SIGLEIF
IPC: B08B9/20
Filed: 2016-12-15
Abstract: A system for cleaning a tank includes four tanks. The first tank stores a processed liquid. The second tank is in fluid communication with the first tank. The second tank includes a separator that separates particles from a dirty liquid to produce the processed liquid. The processed liquid is transferred from the second tank into the first tank. The third tank is in fluid communication with the second tank. The particles are transferred from the second tank to the third tank. The fourth tank stores a clean liquid. The clean liquid has fewer particles per unit volume than the processed liquid. The first tank, the second tank, the third tank, and the fourth tank are positioned on a mobile unit.
Patent CA-3008039-A1 (CA)
Inventor: Saadeh Dennis Elias
IPC: A61K9/20
Filed: 2016-12-07
Abstract: Pharmaceutical compositions for treating, mitigation or prevention inflammatory skin diseases, disorders and/or pathologies are described, the compositions comprising a tetracycline-class antibiotic(s), omega fatty acid(s), and/or nicotinic acid or derivatives thereof. Methods for fabricating the compositions and using them are also described.
Patent CA-3010735-A1 (CA)
Title: Use of n-benzoyl-2-phenyl-3-phenylcarbamoyl-piperidin derivative for treating complement 3 glomerulopathy
Inventor: BEKKER PETRUS
IPC: A61K31/551
Filed: 2017-01-12
Abstract: Methods of treating a human suffering from or susceptible to C3 glomerulopathy comprising administering to the human an effective amount of a C5aR antagonist having the formula (Ie) are provided (see formula Ie)