Patent SG-11202000055P-A (SG)
Title: Antibodies that modulate a biological activity expressed by a cell
Inventor: GEUIJEN CECILIA ANNA WILHELMINA
IPC: C07K16/12
Filed: 2018-07-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau vitivio VIII oviolo OH itio oimIE (43) International Publication Date 10 January 2019 (10.01.2019) W I PO I (10) International Publication Number WO 2019/009728 Al PCT (51) International Patent Classification: C07K 16/28 (2006.01) C07K 16/46 (2006.01) CO7K 16/12 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/NL2018/050451 (22) International Filing Date: Published: with international search report (Art 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) Filing Language: Publication Language: Priority Data: 17180070.9 06 July 2017 (06.07.2017) EP Applicant: MERUS N.V. [NL/NL]; Yalelaan 62, 3584 CM Utrecht (NL). Inventors: GEUIJEN, Cecilia Ana Wilhelmina; c/o Yale- laan 62, 3584 CM Utrecht (NL). KLOOSTER, Rinse; c/ o Yalelaan 62, 3584 CM Utrecht (NL). DE KRUIF, Cor- nelis Adriaan; c/o Yalelaan 62, 3584 CM Utrecht (NL). TACKEN, Paulus Johannes; c/o Yalelaan 62, 3584 CM Utrecht (NL). THROSBY, Mark; c/o Yalelaan 62, 3584 CM Utrecht (NL). LOGTENBERG, Ton; c/o Yalelaan 62, 3584 CM Utrecht (NL). 06 July 2018 (06.07.2018) English English Agent: JANSEN, C.M.; V.O., Carnegieplein 5, 2517 KJ Den Haag (NL). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (25) (26) (30) (71) (72) (74) (81) (84) 1-1 GC N cr\ O O cr\ O 1-1 O (54) Title: ANTIBODIES THAT MODULATE A BIOLOGICAL ACTIVITY EXPRESSED BY A CELL (57) : The invention provides means and methods for interfering with Programmed Cell Death 1 protein (PD-1) and Lympho- cyte activation 3 (LAG 3) mediated inhibition in a PD- 1 and/or LAG3 positive cell. A method may comprise contacting said cell with an antibody or a functional part, derivative and/or analogue thereof that comprises a variable domain that can bind to an extracellular part of PD- 1 and a variable domain that can bind to an extracellular part of LAG3, thereby inhibiting PD-1 and/or LAG3 mediated activity in said cell. The invention also provides antibodies or variants thereof that comprises a variable domain that can bind to an extracellular part of PD- 1 and a variable domain that can bind to an extracellular part of LAG3.