Patent GB-566139-A (GB)
Title: The manufacture of materials resistant to or active against micro-organisms
IPC: A01N39/00
Filed: 1942-11-16
Abstract: Materials resistant to microbiological decomposition, and disinfecting or antiseptic preparations are manufactured by incorporating in materials liable to such decomposition or in the solvent, emulsifying agent, substratum or base of such preparations an ether of ethylene glycol in which one hydroxy group is etherified by an aromatic group.  Such ethers have the formula CH2OH.CH2OR, where R is an aryl or aralkyl group, which may contain such substituents as halogen, alkyl aralkyl; aryl, hydroxy or alkoxy.  The mono-phenyl, benzyl, naphthyl, o-, m- and p-chlorphenyl and o-cresyl ethers are specified.  Mixtures of such ethers with one another or with mono-methyl, ethyl, propyl or butyl ether of glycol have an increased bactericidal effect.  In an example, rubber latex is preserved by 0.5 per cent phenyl or 0.2 p-chlorphenyl ether. Specifications 350,379, [Group VI], and 409,971 are referred to.ALSO:Materials resistant to microbiological decomposition, and disinfecting or antiseptic preparations are manufactured by incorporating in materials liable to such decomposition or in the solvent, emulsifying agent, substratum or base of such preparations an ether of ethylene glycol in which one hydroxy group is etherified by an aromatic group.  Such ethers have the formula CH2OH.CH2OR, where R is an aryl or aralkyl group, which may contain such substituents as halogen, alkyl, aralkyl, aryl, hydroxy or alkoxy. The mono-phenyl, benzyl, naphthyl, o-, m- and p-chlorphenyl and o-cresyl ethers are specified.  Mixtures of such ethers with one another or with mono-methyl, ethyl, propyl or butyl ether of glycol have an increased bactericidal effect.  They may be incorporated with inert powders or in the form of ointments and are applicable in the manufacture of food, cosmetics and pharmaceuticals. Development of fungi and bacteria, and fermentation of yeast in carbohydrates is prevented.  Figures showing the effective concentrations are given. In examples: (1) a disinfectant ointment consists of petroleum jelly, glycerol or glycol, and 2.5 per cent ethylene glycol mono-phenyl ether, or mixtures of the phenyl and butyl, propyl or benzyl ethers; (2) face powder consists of talc and/or starch with 2 per cent phenyl ether; (3) albumen solution is preserved with 1 per cent each of phenyl and butyl ethers; (4) glucose-containing gelatine is preserved by 1 per cent phenyl or 0.4 per cent p-chlorphenyl ether; (5) ordinary or serum broth is preserved by 1.2 per cent phenyl or 0.5 p-chlorphenyl ether; (6) starch paste is preserved with 1 per cent phenyl + 4 butyl ether; (7) milk sugar is mixed with 2 per cent b -naphthyl, 0.75 each of a - and b -naphthyl or 0.5 each o- and p-chlorphenyl ethers; (8) a disinfectant comprises 1 per cent phenyl, 0.5 p-chlorphenyl, and 3 butyl ethers in water; (9) rubber latex is preserved by 0.5 per cent phenyl or 0.2 p-chlorphenyl ether; (10) catgut is sterilized with 2 per cent phenyl, 0.2 p-chlorphenyl, and 2 butyl ethers in water; (11) for instruments and apparatus, 2 per cent each phenyl and butyl ethers are used. Specifications 350,379 and 409,971, [Group V], are referred to.