Patent SG-11201903059S-A (SG)
Title: New anthelmintic quinoline-3-carboxamide derivatives
Inventor: Hübsch Walter
IPC: C07D405/12
Filed: 2017-11-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1111111111101110101011111 01111101 0 0111111011110 11111 001 101111110 1111 0111111 International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/087036 Al 17 May 2018 (17.05.2018) WIPO I PCT (51) International Patent Classification: C07D 215/54 (2006.01) C07D 405/14 (2006.01) CO7D 215/56 (2006.01) A61K 31/47 (2006.01) CO7D 405/12 (2006.01) A61P 33/10 (2006.01) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (21) International Application Number: TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. PCT/EP2017/078319 (84) Designated States (unless otherwise indicated, for every (22) International Filing Date: 06 November 2017 (06.11.2017) kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (25) Filing Language: English TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (26) Publication Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (30) Priority Data: 16198550.2 11 November 2016 (11.11.2016) EP TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (71) Applicant: BAYER ANIMAL HEALTH GMBH Declarations under Rule 4.17: [DE/DE]; Kaiser-Wilhelm-Allee 10, 51373 Leverkusen — as to applicant's entitlement to apply for and be granted a (DE). patent (Rule 4.17(ii)) (72) Inventors: HUBSCH, Walter; Wildsteig 22, 42113 Wup- pertal (DE). KOBBERLING, Johannes; Azalienstr. 30, 41466 Neuss (DE). KOHLER, Adeline; Heimchenweg 9, 40764 Langenfeld (DE). SCHWARZ, Hans-Georg; Published: — with international search report (Art. 21(3)) Auf dem Beerenkamp 82b, 46282 Dorsten (DE). KULKE, Daniel; Dillinger Str. 13, 51375 Leverkusen (DE). WELZ, Claudia; An der Ziegelei 14, 40593 Diisseldor (DE). ILG, Thomas; Plotzenseer Strasse 16, 40789 Monheim (DE). BORNGEN, Kirsten; Feldhasenweg 23, 50859 Köln (DE). ZHUANG, Wei; StauffenbergstraBe 13, 40789 Monheim (DE). GRIEBENOW, Nils; Kurfiirstenstr. 39, 41541 Dor- magen (DE). BOHM, Claudia; Im Seefelde 4a, 30457 Hannover (DE). LINDNER, Niels; Bodelschwinghweg 4, 42115 Wuppertal (DE). HINK, Maike; Eugen-Eisele-Weg 6, 71665 Vaihingen/Enz (DE). GORGENS, Ulrich; Fester Str.37, 40882 Ratingen (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, NRW, 40789 Monheim am Rhein (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, ,_ 1 (54) Title: NEW ANTHELMINTIC QUINOLINE-3-CARBOXAMIDE DERIVATIVES tD R 6 R 2 (57) : The present invention covers new quinoline com- pounds of general formula (I) in which A, R 1 , R, R 2 3 , R 4 , R 5 , M A © N' (I) R 6 , and Q are as defined herein, methods of preparing said com- IN 1 1 00 GC 0 ,„ 0 ei ... rl 4 R R pounds, intermediate compounds useful for preparing said cam- pounds, pharmaceutical compositions and combinations compris- ing said compounds and the use of said compounds for manufac- pharmaceutical compositions for the treatment, control and/ or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.