baber/WOPTO huggingface dataset:
Patent CN-100587983-C (CN)
Inventor: JAE-YUNG LEE
IPC: H01L33/00
Filed: 2006-06-14
Granted: 2010-02-03
Abstract: 提供了一种能够改进亮度不均匀性的发光二极管、其制造方法和具有该发光二极管的背光组件。发光二极管包括用于发出光的发光二极管芯片、以及形成在发光二极管芯片上的用于使光的辐射角扩大的导光元件。因此，最大地扩大了光的辐射角，从而防止了由于亮度不均匀而导致的亮斑现象，这使得提高了图像质量。
Patent CN-100540023-C (CN)
Title: 五妙百灵酊
Inventor: SUOLIANG WANG
IPC: A61K35/62
Filed: 2006-11-12
Granted: 2009-09-16
Abstract: 本发明属于以天然原料制成的医药配制品。一种用于治疗肌肉筋膜性疼痛的五妙百灵酊，选用铁棒锤、生马钱子、蟾皮、川草乌破血活络、祛风、消肿镇痛；秦椒、川椒、川芎、木瓜活血化淤、逐寒祛湿、温筋通络、活络消肿止痛；全蝎、地龙透骨搜络、祛风除湿、活血止痛；冰片、氮酮促进透皮吸收、白酒入药，温通血脉、引药入筋、直达病所，取效最捷。本发明配伍各药相互协同，具有超强渗透作用，外切皮肤，内走经络，善能透骨剔风、散寒化湿、易除络经之瘀。通过临床疗效统计表可以看出，对腰背痛、颈肩痛及风湿性关节炎等具有明显的效果。
Patent CN-100549693-C (CN)
Title: 一种鉴定转基因抗虫植物抗虫性的生物测定方法
Inventor: JIN ZHENG
IPC: G01N33/00
Filed: 2006-11-08
Granted: 2009-10-14
Abstract: 一种鉴定转基因抗虫植物抗虫性的生物测定方法。以离体培养的粉纹夜蛾细胞为试材，通过转基因抗虫植物蛋白质对昆虫细胞的毒性，测定转基因抗虫植物的抗虫性。由于活细胞线粒体内的琥珀酸脱氢酶与MTT反应生成蓝紫色结晶产物甲臜，甲瓒颜色深浅与活细胞数成正比，通过在570nm的波长下测定其OD值，测算出活细胞的数目，而死细胞中琥珀酸脱氢酶消失，不能将MTT还原。利用昆虫细胞测定转基因抗虫植物的抗虫性，便于从分子水平观察分析转基因抗虫植物的杀虫机理。离体培养的昆虫细胞相对于饲养或田间的活体昆虫而言，其均一性好，不易受外界环境和活体昆虫体壁、肠道内蛋白酶活性、体液pH值等因素的影响。此法操作简单、便捷，节省人力、物力。
Patent CN-100463436-C (CN)
Inventor: YUZHU HOU
IPC: H04L45/16
Filed: 2006-08-29
Granted: 2009-02-18
Abstract: 本发明公开了弹性分组环性能测试环境的构建方法，包括步骤：RPR主节点接收要求进入测试环境的命令；主节点广播功能报文，该功能报文携带有关闭中断处理的标识；主节点关闭中断处理；从节点根据标识关闭中断处理；主节点广播功能报文，该功能报文携带有停止发送控制报文和公平报文的标识；主节点停止发送控制报文和公平报文；从节点根据标识停止发送控制报文和公平报文。本发明新增加的RPR设备的工作模式，为实际RPR组网构建了一个准确测试其性能的环境，方便了设备厂商对RPR设备性能的准确说明，同时也方便了运营商对RPR设备进行准确的评估测试。本发明还公开了RPR系统以及主节点、从节点。
Patent CN-100499247-C (CN)
Title: 非水电解质二次电池
Inventor: TAKAYUKI SHIRANE
IPC: H01M10/058
Filed: 2006-03-23
Granted: 2009-06-10
Abstract: 本发明公开了一种非水电解质二次电池，其包含：含有含镍的锂复合氧化物的正极、包含石墨的负极、以及非水电解质。所述非水电解质二次电池的充电截止电压为4.25-4.6V。所述负极包含在高于石墨电位的电位下与锂反应的添加剂。正极容量A与负极材料混合物层的对着正极材料混合物层的部分中包含的所述石墨的重量B的比例A/B为300-340mAh/g，所述正极容量A是以所述含镍的锂复合氧化物的重量和所述充电截止电压为基础的；并且正极的不可逆容量C和所述负极的对着所述正极的部分中的不可逆容量D满足关系C≥D。
Patent CN-100588921-C (CN)
Inventor: CHEN ZHANG
IPC: G01K7/16
Filed: 2007-07-05
Granted: 2010-02-10
Abstract: 可恢复式缆式线型感温探测器，由感温电缆两端分别与微机调制器和终端电阻R连接形成闭路信号采集电路，其特征在于感温电缆的结构是一根弹性金属导体包覆维卡软化点为40℃～180℃范围内的可熔融NTC特性材料层，另一根是弹性金属导体，两根线芯之间夹一根有孔的带状绝缘阻隔层后一起绞合或缠绕在一起，最后一起挤塑外护套层。微机调制器内存中设置了感温电缆1米长受热的多个报警温度信号启动阻值量，并监测导体间可熔融NTC特性材料层的阻值变化量，当环境温度使可熔融NTC特性材料层软化，弹性金属导体与可熔融NTC特性材料层短路，实现定温报警信号输出；当非火灾因素使两根导体之间发生短路及断路时，通过微机调制器输出短路及断路故障信号。优点是工艺简单，生产效率高，生产成本低。
Patent CN-100450971-C (CN)
Inventor: RONGLIN WANG
IPC: C04B35/65
Filed: 2007-02-12
Granted: 2009-01-14
Abstract: 本发明涉及一种Al-AlN-ZrO 2 陶瓷材料的制备方法，属陶瓷基复相金属陶瓷结构材料领域。该复相材料制备工艺方法主要包括：配合料湿法混合、材料成型、高温烧结、氧化处理等。湿法混合工艺是将Al、部分稳定ZrO 2 、AlN、助烧剂SrCO 3 或TiO 2 经配料及干混后，加入足够量的无水乙醇进行湿法搅拌30分钟；材料采用压力成型，成型压强为20MPa-100MPa；材料采用高温氮化烧结，烧结温度为1400-1600℃，保温时间为2h-6h；对氮化烧结后的材料表面再进行氧化处理，氧化处理的温度为960℃，恒温30分钟。该技术工艺是高抗热震Al-AlN结合ZrO 2 复相材料的制备方法。
Patent CN-100534130-C (CN)
Inventor: JIANCHENG LI
IPC: H04N21/466
Filed: 2007-11-20
Granted: 2009-08-26
Abstract: 本发明涉及通信领域，提供了一种向电视用户推荐节目的方法、系统及设备。所述方法包括以下步骤：A.记录用户的频道切换行为，生成频道切换表；B.根据节目时间表和频道切换表计算电视节目的收视热度，并根据收视热度生成节目推荐表；C.将节目推荐表发送并显示给用户。本发明通过对包含用户行为信息的频道切换表进行分析，精确计算每个节目的收视热度并进行排序，从而将最受欢迎的节目推荐给电视用户，提高了节目推荐的准确性。
Patent CN-100538445-C (CN)
Title: 有透明导电镍酸锂底电极的外延铌酸锶钡薄膜及制备方法
Inventor: PIYI DU
IPC: G02F1/035
Filed: 2007-11-01
Granted: 2009-09-09
Abstract: 本发明公开了一种具有透明导电镍酸锂底电极的外延铌酸锶钡薄膜及制备方法。在MgO基板一面外延沉积LNO镍酸锂透明导电层LNO薄膜，再在LNO薄膜上外延制备SBN薄膜。其制备步骤如下：首先以碳酸锂，氧化镍，氧化铌，碳酸锶，碳酸钡为原料，用固相烧结法分别制备镍酸锂靶材和铌酸锶钡靶材；其次将(001)MgO基板清洗后放入反应室，反应室抽真空，并加热基板，以氧气为保护气体，引入反应室中，脉冲激光溅射靶材，在基板上先后外延沉积镍酸锂导电电极和铌酸锶钡薄膜。本发明制备方法简单，制得的铌酸锶钡薄膜为(001)方向外延生长，薄膜外延性好，质量高，电光系数大(r33可达180～230pm/V)，具有良好的应用前景。
Patent CN-100577272-C (CN)
Inventor: HONGXING YAO
IPC: G05D11/00
Filed: 2007-11-30
Granted: 2010-01-06
Abstract: 本发明公开了一种动态配料数字控制系统，包括：计算机控制系统，用于根据生产计划确定总流量自动生成配料单并进行分配，和进行A/D转换以及获得变频器输出频率；配料圆盘，与所述计算机控制系统通信连接，用于根据所述配料单给出的具体的配料流量；称重传感器，安装在称重皮带与所述计算机控制系统通信，检测所述配料圆盘配给的矿石重量并将检测到的数据反馈给计算机控制系统；变频电机，与计算机控制系统和配料圆盘通信连接，用于按照计算机控制系统根据检测到的数据进行A/D转换获得的变频器输出频率调节速度，进而调节所述配料圆盘的转速。以及还公开了一种动态配料数字控制方法。因此通过本发明控制系统和控制方法减少工程建设成本和使用维护成本，提高配料精度。
Patent CN-100558831-C (CN)
Inventor: FANHUI KONG
IPC: C09D11/50
Filed: 2008-05-13
Granted: 2009-11-11
Abstract: 一种紫口珠光光变防伪油墨，包括防伪颜料、连结料、填料、流平剂、润湿剂、消泡剂、溶剂，其特征在于，各种组份的重量比例如下：颜料为绿变紫防伪颜料5～30g，连结料为丙烯酸树脂20～40g，填料为珠光粉5～20g，流平剂0.3～3g，润湿剂0.3～3g，消泡剂0.5～3g，溶剂为正丙酯40～60g。本发明具有以下特点：1、本发明的光变油墨不易仿制、保真性强，提升了实际的防伪价值。2、紫口珠光变色油墨，通过添加紫口珠光粉，补充了传统变色油墨无法实现的“蓝变紫”的色变色系。3、紫口珠光变色油墨，通过添加紫口珠光粉使得变色油墨颗粒变得粗大，油墨固含量增大，在同等油墨用量的基础上，可较多的获得印刷品数量、提高产出率、提升印刷质感。
Patent CN-100588929-C (CN)
Inventor: YANFU LI
IPC: G01L27/00
Filed: 2008-12-23
Granted: 2010-02-10
Abstract: 一种高效高压传感器试验机，它包括一带脚轮的底板，技术要点是：底板上连接机柜和压力发生系统；该系统包括固定设置在底板上的油箱，油箱上部依次设置有电机和变量泵，其压力出口通过电磁调压阀、伺服溢流阀与管路连接，管路并联成三路后，通向保持封闭的试验区；在试验区内设置有通过卡套式接头的转换连接至安装夹具，每路安装夹具上有二至八个安装工位，该安装工位装有一只标准压力传感器和若干被试压力传感器，在安装夹具中的压力入口端串连加压阀，在安装夹具的压力出口端串连截止阀，三路压力管路通过截止阀后，再并联到一路，连接到试验区下部的漏液排放口；在机柜的上部镶嵌有一平板电脑及电气操作区。
Patent MX-3361-E (MX)
Title: Sistema de control de los vapores de los hornos de arco
Inventor: OVERNYER ROBERT C
IPC: F27D17/00
Filed: 1976-06-25
Abstract: La presente invención se refiere a un sistema de control de los vapores de los hornos de arco, caracterizado porque comprende un crisol que ofrece un embocadero dirigido hacia arriba, un techo que cubre ese embocadero y que es susceptible de moverse hacia una posición de abertura apartada del embocadero, una pluralidad de electrodos de arco que se extiende hacia abajo através del techo, teniendo el crisol por lo menos una boca de vaciado que se abre en su interior y siendo del crisol susceptible de inclinación con fines de sangría y para eliminar la escoria, comprendiendo el sistema de control medios de escape, un primer medio de capuchón para recoger en el techo los vapores generados durantae  las operaciones del horno, un primer medio de conducto para conectar el primer medio de capuchón con el medio de escape, siendo susceptible de moverse el primer medio de capuchón juntamente con el techo para dejar expuesto en el embocadero y haciendo posible el primer medio de conducto del movimiento del primer medio de capuchón, y medios de capuchón de carga, para cubrir el embocadero cuando el primer medio de capuchón y el techo se apartan del embocadero.
Patent PT-1093633-E (PT)
Title: Iris identification system and method of identifying a person through iris recognition
Inventor: KIM DAE-HOON
IPC: G06K9/00
Filed: 2000-04-07
Abstract: An iris identification system and method of identifying the identity of an animate being through iris scanning are disclosed. The system features an iris system pick-up unit including a camera for capturing iris images to create input image signals. The iris image pick-up unit is operated with a control unit that is interfaced with a data processing unit for preprocessing the input image signals into processed data. The processed data is representative of one of a plurality of parameters for iris identification selected from the group consisting of (1) the density and texture form of the iris fiber structure using a frequency transformation method, (2) pupilliary reaction, (3) the shape of the pupil, (4) autonomous nervous wreath reaction, (5) shape of the autonomous nervous wreath, (6) the existence of lacuna, (7) the location of the lacuna, and (8) the shape of the lacuna. The control unit is operable to compare processed data with parameters pre-stored in a data base that correspond to the processed data parameters to determine a match indicative of a confirmation of identity.
Patent PT-1194500-E (PT)
Inventor: VERMEIREN WALTER
IPC: B01J29/40
Filed: 2000-06-08
Abstract: A process for the catalytic cracking of an olefin-rich feedstock which is selective towards light olefins in the effluent, the process comprising contacting a hydrocarbon feedstock containing one or more olefins, with an MEL-type crystalline silicate catalyst, which has been subjected to a steaming step and has a silicon/aluminium atomic ratio of from 150 to 800, at an inlet temperature of from 500 to 600 DEG C, at an olefin partial pressure of from 0.1 to 2 bars and the feedstock being passed over the catalyst at an LHSV of from 5 to 30h<-1>, to produce an effluent with an olefin content of lower molecular weight than that of the feedstock.
Patent PT-1129960-E (PT)
Inventor: GOGLIO FRANCO
IPC: B65D75/56
Filed: 2001-01-04
Abstract: A container of flexible material, obtained by successive folding and sealing of a sheet material (2) comprising at least two layers (3, 4) coupled to one another by means of adhesive (20), said container being provided with an upright top edge (8), in which a handle (11) is made by punching, an uncoupled area (23; 123) being provided around said handle (11), in order to increase resistance to tearing when stress is applied by gripping the handle. <IMAGE>
Patent PT-1265614-E (PT)
Inventor: JOZSEF-MICHEL GECZY
IPC: A61K47/38
Filed: 2001-02-22
Abstract: The present invention relates to a novel sustained-release oral galenical form of molsidomine for the treatment of all forms of angina attack (angina of effort, spastic angina, mixed angina). According to the invention, this novel galenical form contains a therapeutically effective amount of molsidomine or one of its active metabolites and has an in vitro dissolution rate [measured spectrophotometrically at 286 or 311 nm by the method described in the European Pharmacopoeia, 3rd edition (or USP XXIV), at 50 rpm, in 500 ml of a 0.1 N HCl medium, at 37° C.] of: 15 to 25% of molsidomine released after 1 hour, 20 to 35% of molsidomine released after 2 hours, 50 to 65% of molsidomine released after 6 hours, 75 to 95% of molsidomine released after 12 hours, >85% of molsidomine released after 18 hours and >90% of molsidomine released after 24 hours, the plasma peak of molsidomine obtained in vivo occurring 2.5 to 5 hours, preferably 3 to 4 hours, following the administration of said form, and having a value of between 25 and 40 ng/ml of plasma. Application: therapeutics industry.
Patent PT-1231268-E (PT)
Inventor: SHARON JACQUELINE
IPC: C12P21/04
Filed: 1995-01-27
Abstract: The invention is directed to methods for the creation and use of libraries of proteins which comprise polyclonal antibodies to a common antigen or group of antigens, receptor proteins with related variable regions, or other immune related proteins with variable regions. These polyclonal antibody libraries can be used to treat or prevent diseases and disorders including neoplasia such as cancer and other malignancies, parasitic infections, bacterial infections, viral infections and disorders such as genetic defects and deficiencies. Protein libraries may be patient-specific, disease-specific or both patient- and disease-specific. Libraries can also be used to detect a disease or disorder in a patient either by direct imaging or through the use of a diagnostic kit. The invention further includes novel cloning methods for the creation and transfer of nucleic acid sequences encoding protein variable regions and novel cloning vectors.
Patent PT-1525155-E (PT)
Title: Waste-heat boiler for a claus plant
Inventor: THIELERT HOLGER
IPC: C01B17/04
Filed: 2003-05-09
Abstract: The boiler for a Claus reactor has a steam generating zone within a pressure-tight mantle (14). A longitudinal tube bundle (18) acts as the heat exchanger through the steam zone, with both ends at tube bases (19) defining the steam zone. At least a further bundle (20) of shorter tubes has their outflow ends at the tube base and their inflow ends opening into a flow chamber (21) within the steam zone. A head piece (22), divided into sections, is at the tube base. A hot process gas from the combustion chamber (2) flows through the long tube bundle. A cooler gas from a catalyst stage (4) flows through the shorter tube bundle. The sections of each head piece are each linked to a tube bundle, to lead off condensed sulfur.
Patent PT-1563157-E (PT)
Title: Method for making a movable window pane for a vehicle and vertically movable window pane mobile for vehicle
Inventor: KOTTE ROLF
IPC: E05F11/38
Filed: 2003-08-13
Abstract: A method for fabrication of a vehicle drop glass, with a transparent, in particular curved, pane, on the extremity of which a support part is to be attached, which cooperates with a drive and/or guide device for heightwise movement of the pane. In the method the pane is oriented and attached at plural predetermined points of its surface in a device adapted to its shape, a curable plastic material is deposited on the pane with aid of at least one tool in the region of the assembly with the support part and is fashioned, in a fixed position in the space inside the device, into a fashioned part which, after its assembly with the pane, defines the position of the support part in relation to the predetermined points. The plastic material is then cured. A window pane can be produced according to the method.
Patent PT-1601677-E (PT)
Title: Spiro-substituted pyrrolopyrimidines
Inventor: IRIE OSAMU
IPC: C07D519/00
Filed: 2004-02-27
Abstract: The invention provides compounds of formula I or a pharmaceutically acceptable salt or ester thereof formula I wherein the symbols have the meaning as defined in the description. Said compounds are inhibitors of cathepsin K and/or cathepsin S and are useful for the treatment of diseases and medical conditions in which cathepsin K and or cathepsin S is implicated, e.g. various disorders including neuropathic pain, inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, multiple sclerosis and tumours.
Patent PT-1648494-E (PT)
Title: Anti-angiogenetic agent and its use in cancer treatment
Inventor: PLOUET JEAN
IPC: A61P9/00
Filed: 2004-07-30
Abstract: The present invention relates to the use of a protein characterized in that it comprises or is constituted by the NOV protein, represented by the sequence SEQ ID NO: 2, or a fragment of this protein, providing that this fragment exhibits an angiogenesis-inhibiting activity, or any sequence derived from the sequence SEQ ID NO: 2 or from a fragment defined above, providing that this derived sequence exhibits an angiogenesis-inhibiting activity, or any sequence homologous to the sequence SEQ ID NO: 2 or to a fragment defined above, providing that this homologous sequence exhibits an angiogenesis-inhibiting activity, for the preparation of a medicament intended for the treatment of pathologies requiring the inhibition of endothelial proliferation or of pathologies requiring the inhibition of endothelial activation.
Patent PT-1595836-E (PT)
Title: Device for processing stacks of electrostatic rechargeable flat parts
Inventor: HAGEMANN GUENTHER
IPC: B65H35/04
Filed: 2004-09-17
Abstract: The apparatus advances a web lengthwise in a predetermined direction along a predetermined path. The web has a subdividing arrangement at a portion of the path, so that the web yields a succession of discrete stacks. The advancement device has a first unit at a second portion of the path upstream of the first portion, as seen in the direction, and a second unit at a third portion of the path downstream of the first portion, as seen in the direction. An electrostatic charging device is provided for the web. The device is located in the region of one of the units adjacent to a cutting device. The charging device is located between the subdividing arrangement and one the units. An endless band conveyor having an upper reach is arranged to support a portion of the multi-layer web.
Patent PT-1707181-E (PT)
Title: Dye composition with a reduced content of starting materials, and process for dyeing keratin fibres using the same
Inventor: LEGRAND FREDERIC
IPC: A61K8/73
Filed: 2006-03-28
Abstract: Coloring composition for dyeing the keratinous fibers comprises an oxidation dye precursor and/or a direct dye, nonionic and/or anionic surface-active agents, hydroxyethylcellulose, a cation associated polymer and a fatty substance, where the weight ratio of the surface-active agents to the fatty substance is >=1.75 and the water is present at at least 40 wt.%. Independent claims are included for: (1) a process of coloring keratinous fibers comprising, applying dry or wet coloring composition to the fibers; and (2) a device with several compartments for coloring the keratinous fibers, comprising a first compartment containing the coloring composition and a second compartment containing an oxidizing composition.
Patent PT-1968756-E (PT)
Title: Method for obtaining a bio-stabilised woodland substrate from the integral cycle of urban solid waste treatment
Inventor: CERRONI MANLIO
IPC: B09B3/00
Filed: 2006-12-08
Abstract: A method for obtaining a woodland substrate from the complete recycling of the materials recovered from treatment of urban solid waste is disclosed. The woodland substrate obtained by the process is also described.
Patent PT-2014304-E (PT)
Title: Colon cleansing compositions
Inventor: UNGAR ALEX
IPC: A61K33/04
Filed: 2003-10-24
Abstract: The present invention relates to orthostatic lavage solutions, colon evacuants or colon cleansing compositions, also known as lavage compositions for cleansing the gastrointestinal tract, and methods of use of such compositions.
Patent PT-659073-E (PT)
Inventor: LANGER ROBERT S
IPC: A61K9/52
Filed: 1993-09-10
Abstract: An improved biodegradable controlled release system consisting of a polymeric matrix incorporating a local anesthetic for the prolonged administration of the local anesthetic agent, and a method for the manufacture thereof, are disclosed. The polymers and method of manufacture used to form the PLAMs are selected on the basis of their degradation profiles: release of the topical anesthetic in a linear, controlled manner over a period of preferably two weeks and degradation in vivo with a half-life of less than six months, more preferably two weeks, to avoid localized inflammation. Alternatively, a non-inflammatory can be incorporated into the polymer with the local anesthetic to prevent inflammation. <IMAGE>   <IMAGE>
Patent PT-680327-E (PT)
Inventor: LABRIE FERNAND
IPC: A61K31/57
Filed: 1994-01-19
Abstract: Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment and/or prevention of vaginal atrophy, hypogonadism, diminished libido, osteoporosis, urinary incontinence, ovarian cancer, uterine cancer, skin atrophy, for contraception, and, in combination with an estrogen and/or progestin, for the treatment of menopause. The precursors may be formulated for percutaneous or transmucosal administration. Gels, solutions, lotions, creams, ointments and transdermal patches for the administration of these precursors are provided, as are certain pharmaceutical compositions and kits which can be used for the prevention and treatment of a wide variety of conditions related to decreased secretion of sex steroid precursors by the adrenals.
Patent PT-684806-E (PT)
Inventor: HEIBER SONIA J
IPC: A61K9/00
Filed: 1994-02-03
Abstract: A method and system for mucosally administering a macromolecular drug to mucosa of the oral cavity is shown. The system comprises an inner drug/enhancer/polymer layer having one surface adapted to contact and adhere to the mucosal tissue of the oral cavity and an opposing surface in contact with and adhering to an overlying inert layer. The inner layer contains from about two to sixty percent by weight of a bile salt enhancer, five to sixty five percent by weight of a hydrophilic polymer which is water soluble or swellable and an effective amount of a macromolecular drug having a molecular weight of at least 500 daltons. Polysaccharides, polypeptides and proteins are preferred forms of macromolecular drugs. The bile salt enhancer facilitates the delivery of macromolecules such as low molecular weight heparin and calcitonin. The polymer serves as a plasticizer to prevent the crystallization and/or aggregation of such macromolecular drugs. Hydroxypropyl cellulose is a particularly suitable polymer.
Patent PT-678337-E (PT)
Inventor: ROWE RAYMOND CHARLES
IPC: A61M11/00
Filed: 1995-03-22
Abstract: A method of administering to the eye a liquid ophthalmic formulation, comprising an ophthalmologically acceptable liquid and optionally containing an ophthalmologically-active substance, characterized in that the formulation has a viscosity in the range 10<-><3> to 1.0Pa.s and a resistivity lower than 10<4>ohm.cm, and that a jet of the formulation is ejected towards the eye, from a spray nozzle (12) situated adjacent to a piezoelectric or electromagnetic transducer (7), to form a stream of uniformly-sized, equally spaced, uncharged droplets, the stream of uncharged droplets is subsequently directed past a charging electrode (13) to induce an electric charge on each droplet in the stream, and the charged droplets discharge their electric charge by earthing on contact with the eye; and spraying apparatus suitable for use in that method. <IMAGE>
Patent PT-835447-E (PT)
Title: Novel peptides and compositions which modulate apoptosis
Inventor: CHITTENDEN THOMAS D
IPC: A61K38/00
Filed: 1996-05-06
Abstract: The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the "GD domain," which is essential both to Bak's interaction with Bcl-xL, and to Bak's cell killing function. Methods of identifying agonists or antagonists of GD domain function are provided. The GD domain is responsible for mediating key protein/protein interactions of significance to the actions of multiple cell death regulatory molecules.
Patent PT-841913-E (PT)
Inventor: KRAUSE BRIAN ROBERT
IPC: A61K31/00
Filed: 1996-07-08
Abstract: PCT No. PCT/US96/11366 Sec. 371 Date Jan. 26, 1998 Sec. 102(e) Date Jan. 26, 1998 PCT Filed Jul. 8, 1996 PCT Pub. No. WO97/05868 PCT Pub. Date Feb. 20, 1997The present invention is directed to new therapeutic uses of compounds of formula: wherein X and Y are oxygen, sulfur, or (CR'R'')n wherein n is 1 to 4; R is hydrogen, alkyl, or benzyl; R1 and R2 are phenyl, substituted phenyl, naphthyl, substituted naphthyl, an aralkyl group, an alkyl chain, adamantyl, or a cycloalkyl group. The uses are cerebrovascular disease such as stroke, peripheral vascular diseases, and restenosis.
Patent PT-852497-E (PT)
Inventor: SCHOLZ PETER
IPC: A61K47/40
Filed: 1996-08-06
Abstract: PCT No. PCT/EP96/03481 Sec. 371 Date Apr. 23, 1998 Sec. 102(e) Date Apr. 23, 1998 PCT Filed Aug. 6, 1996 PCT Pub. No. WO97/06806 PCT Pub. Date Feb. 27, 1997A method is described for treating bacterially induced meningitis, comprising administering a prostane derivative of formula I or Ia wherein X1, X2, X3, X4, X5, R1, R2, R3 and R4 are as described below, and the -O-R3- group is in the  alpha - or  beta -configuration. The prostane derivative can optionally comprise or serve as an adjuvant, and it can be administered in combination with an antiobiotic.
Patent PT-862646-E (PT)
Inventor: RIGBY STUART RICHARD
IPC: C12P41/00
Filed: 1996-11-19
Abstract: PCT No. PCT/GB96/02838 Sec. 371 Date May 26, 1998 Sec. 102(e) Date May 26, 1998 PCT Filed Nov. 19, 1996 PCT Pub. No. WO97/19185 PCT Pub. Date May 29, 1997Optically active 2-substituted tetrahydropyran-4-ols or esters thereof may be prepared using esterases or hydrolases from the corresponding racemic mixtures of esters or alcohols. This provides a route to the corresponding optically active ketones. The racemic mixtures are preferably in the cis-form. such mixtures may be produced by reacting but-3-ene-1-ol with an aldehyde in the presence of an acid.