baber/WOPTO huggingface dataset:
Patent DK-0635507-T3 (DK)
Inventor: BARKER ANDREW JOHN
IPC: C07D498/04
Filed: 1994-07-15
Granted: 2000-03-27
Abstract: The invention concerns tricyclic derivatives of the formula I <CHEM> wherein R<1> and R<2> together form an optionally substituted group of the formula -N=CH-NH-, -N=CH-O-, -N=CH-S-, -N=N-NH-, -NH-N=CH-, -NH-CH=CH-. -NH-CO-NH-, -NH-CO-O-, -NH-CO-S-, -NH-NH-CO-, -N=CH-CH=N-, -N=N-CH=CH-, -N=CH-N=CH-, -N=CH-CH=N-, -NH-CO-CH=CH- or -N=CH-CO-NH-;  m is 1, 2 or 3 and R<3> includes hydrogen, halogeno and (1-4C)alkyl;  or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.
Patent DK-0679161-T3 (DK)
Inventor: DUBROEUCQ MARIE-CHRISTINE
IPC: A61P43/00
Filed: 1994-01-03
Granted: 1999-02-01
Abstract: PCT No. PCT/FR94/00007 Sec. 371 Date Jun. 6, 1995 Sec. 102(e) Date Jun. 6, 1995 PCT Filed Jan. 3, 1994 PCT Pub. No. WO94/15955 PCT Pub. Date Jul. 21, 1994Derivatives of formula (I), their salts, the preparation of said derivatives and drugs containing same. The compounds of formula (I) have interesting pharmacological properties. Said compounds have a high affinity for cholecystokinin (CCK) and gastrin receptors and are therefore useful in the treatment and prevention of CCK and gastrin-related disorders affecting the nervous system and gastrointestinal tract    <IMAGE>  (I)
Patent DK-0773806-T3 (DK)
Inventor: FREZZA PIERRE
IPC: A61M5/28
Filed: 1994-02-07
Granted: 1999-03-29
Abstract: PCT No. PCT/FR94/00137 Sec. 371 Date Sep. 8, 1995 Sec. 102(e) Date Sep. 8, 1995 PCT Filed Feb. 7, 1994 PCT Pub. No. WO94/17846 PCT Pub. Date Aug. 18, 1994A metering instrument for dispensing several doses of a liquid includes a tubular body designed to be held by the user, a reservoir containing the liquid, a movable tail mounted inside and on the axis of body, and a pusher grippable by the user and mounted translationally in the body. The tail has a rack constituted by successive annular notches, and the body has several axial slots distributed over its periphery. The pusher includes an outwardly projecting pin that is designed to engage one of the axial slots of the body.
Patent DK-0729460-T3 (DK)
Inventor: KOENIG WOLFGANG
IPC: C07D401/12
Filed: 1994-10-24
Granted: 2002-08-19
Abstract: 5-Membered ring heterocycle of the formula I,in which D includes a COOR15, CON(CH3)R15 or CONHR15 radical and R15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparation and use as inhibitors of thrombocyte aggregation, metastasization of carcinoma cells, binding of osteoclasts to bone surfaces and for the treatment of tromboses.
Patent DK-0675575-T3 (DK)
Inventor: BRUCK JOCHEN
IPC: F21V21/34
Filed: 1995-01-27
Granted: 2000-08-28
Abstract: The LV current conductor (1) has an insulator (2), with a rectangular cross-section, provided with metal mesh bands (3,...6) on each of its major surfaces, providing the current paths for respective phases. The insulator is provided by a profiled rail, with profile chambers (7,...10) on both sides for receiving the respective metal mesh bands, defined by profile flanges. Pref. the insulator has a symmetrical profile cross-section, e.g. a double T profile, with a ratio of 5:30 between the greatest profile width and the profile height. <IMAGE>
Patent DK-0760474-T3 (DK)
Inventor: FORSTER MARTIN DR
IPC: G01N21/00
Filed: 1995-09-04
Granted: 2004-09-20
Abstract: The sensor provides uses a cylindrical sensor body (1) containing a cylindrical measuring cell (13) with a permeable membrane, their longitudinal axes positioned at right angles to one another. The length of the measuring cell is determined by the required measuring sensitivity and measuring range, while the size of the sensor body remains constant. The measuring cell is illuminated by an intensity modulated light source (5), monitored via a photodiode, with the acoustic pressure wave generated by the photoacoustic effect detected by a microphone (4), all of which are fitted beneath the cover (14) of the sensor body.
Patent DK-0754048-T3 (DK)
Inventor: ATTIE KENNETH
IPC: C12N15/09
Filed: 1995-03-24
Granted: 2001-11-05
Abstract: Methods for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome, but not Laron syndrome, are described. One such method comprises administering a dose of greater than 0.3 mg/kg/week of growth hormone, preferably growth hormone with a native human sequence, with or without an N-terminal methionine, to the patient. The patient is characterized as having a height of less than about -2 standard deviations below normal for age and sex, serum levels of high-affinity growth hormone binding protein and IGF-I that are at least 2 standard deviations below normal levels, and a serum level of growth hormone that is at least normal. In another such method, the same patient population is treated with an effective amount of IGF-I alone or in combination with an amount of growth hormone that is effective in combination with IGF-I.
Patent DK-0788537-T3 (DK)
Inventor: HEES UDO
IPC: C11D1/83
Filed: 1995-10-20
Granted: 1999-11-01
Abstract: PCT No. PCT/EP95/04124 Sec. 371 Date Apr. 28, 1997 Sec. 102(e) Date Apr. 28, 1997 PCT Filed Oct. 20, 1995 PCT Pub. No. WO96/13567 PCT Pub. Date May 9, 1996A process for increasing the solubility and surfactant content of a concentrated aqueous manual dishwashing detergent composition by adding to the composition a glycerol sulfate.
Patent DK-0796340-T3 (DK)
Inventor: VALENTINE BRIAN PETER
IPC: C12P17/18
Filed: 1995-12-07
Granted: 2003-05-05
Abstract: Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes, particularly urease, are disclosed.
Patent DK-0755799-T3 (DK)
Inventor: MANTEGAZZA WALTER
IPC: B42D15/00
Filed: 1996-07-17
Granted: 2000-01-03
Abstract: A document with anti-counterfeiting means to prevent reproducibility by photocopying, having a sheet-like element (2) that has, on its face, at least one region whereon an image (3) that is visible or not visible in the visible-light range is printed and has, on the back, in register with the image provided on the face, the same image, printed with an ink that is not visible in the visible-light range. <IMAGE>
Patent DK-0795538-T3 (DK)
Inventor: JACKSON BARRY DR
IPC: B01J31/02
Filed: 1997-03-12
Granted: 1999-12-20
Abstract: Production of pure alkyl alkylacetoacetate of formula CH3COCH((CH2)2R1)COOR2 (I) from a mixture of (I) and an alkyl alkenylacetoacetate (II) of formula CH3COCH(CH=CHR1)COOR2 or CH3COC(=CHCH2R1)COOR2 and optionally additional byproducts comprises reaction with an alkyl acetoacetate of formula CH3COCH2COOR2 (III) in the presence of a strong base and isolation of the intermediate formed between (II) and (III). R1 = 1-10C alkyl; R2 = 1-4C alkyl.
Patent DK-0820439-T3 (DK)
Inventor: SCHWARTZ JEAN-CHARLES
IPC: C12P7/62
Filed: 1997-02-04
Granted: 2000-08-07
Abstract: PCT No. PCT/FR97/00218 Sec. 371 Date Nov. 26, 1997 Sec. 102(e) Date Nov. 26, 1997 PCT Filed Feb. 4, 1997 PCT Pub. No. WO97/29086 PCT Pub. Date Aug. 14, 1997Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl-3-phenylpropanoic acid of formula (I): characterized in that it comprises the steps consisting in: a) preparing the diol (VI) by reduction of a malonic ester (V) in the presence of a hydride; b) preparing the monoacetates (VII R) or (VII S) respectively; c) subjecting these monoacetates to an oxidation in order to form the acids (IX S) or (IX R); d) saponifying the compounds (IX S) or (IX R) in order to form the hydroxy acids (X S) or (X R); e) thioacylating the hydroxy acids (X S) or (X R) with a mercapto acid R1SH (XI), according to a Mitsunobu-type reaction, in order to lead to the desired acids (I R) (I S) respectively and application to the synthesis of N-(mercaptoacyl)amino acid derivatives (II).
Patent DK-0892915-T3 (DK)
Inventor: DANG NGUYEN THAI
IPC: G01F11/04
Filed: 1997-04-03
Granted: 2010-06-07
Abstract: A syringe as disclosed having an elongated cylindrical tube open at both a first and second end. The first open end of the tube provides both a filling and dispensing opening for the contents of the tube. A cylindrical piston is slidably mounted within the tube and has a first axial end facing the fill and dispensing opening and a second axial end facing the opposite or second opening. The piston has an outside diameter slightly smaller than the inside diameter of the tube so that an annular clearance space is formed between the tube and the piston. A wiper extends radially outwardly from the second end of the piston and frictionally engages the cylindrical internal surface of the tube. In practice, when the syringe is filled, air is compressed through the annular opening and deflects the wiper such that the air escapes out of the syringe tube. The fill material, however, is sufficiently viscous such that, after air has been expelled from the tube, the viscous material slidably displaces the piston within the interior of the tube. A novel tamper evident cap is also disclosed for closing the second end of the tube.
Patent DK-0908176-T3 (DK)
Inventor: BJOERKMAN SVEN DR
IPC: A61P37/00
Filed: 1998-09-18
Granted: 2003-01-06
Abstract: Stable, aqueous form of (+)-(R)-thalidomide or (-)-(S)-thalidomide contains the enantiomer of thalidomide dissolved in pure form in isotonic glucose solution and has a pH ≤ 5.5. An Independent claim is also included for the production of the aqueous thalidomide solution, comprising: (a) adding (+)-(R) or (-)-S-thalidomide to isotonic glucose at pH 4-5; (b) shaking until dissolution is complete; and (c) treating with ultrasound and filtering under aseptic conditions. Use of pure enantiomers of thalidomide allows water-stable solutions that do not give rise to toxicological effects. The enantiomers have higher solubility in water than the racemate. At pH ≤ 5.5, hydrolysis of thalidomide does not occur. Solutions are suitable for parenteral administration.
Patent ES-2261113-T3 (ES)
Title: Aguja para maquina de coser con bordes del ojo desplazados.
Inventor: VORNHOLT HARRY
IPC: D05B85/00
Filed: 2000-03-30
Granted: 2006-11-16
Abstract: Aguja (1) para máquina de coser, con un vástago (2) configurado esencialmente recto, que se conecta a una parte de sujeción, se extiende a lo largo de un eje (4) central, y termina en una punta (3), con una ranura (21) para el hilo, que presenta un fondo (24) esencialmente plano, que discurre a alguna distancia, paralelo al eje (4) central, y que presenta una profundidad notable para alojar el hilo y minimizar la fricción entre el hilo (38) y el producto a coser, con un ojo (11) que está limitado por dos bordes (12, 14) del ojo distanciados uno de otro en la dirección del eje (4) central, y que están desplazados uno respecto al otro transversalmente (9) al eje (4) central, caracterizada porque cada uno de los bordes (12, 14) del ojo, presenta un espesor medido transversalmente al eje (4) central, que es al menos el 40% del grosor nominal de la aguja, y cada uno de los bordes (12, 14) del ojo, con una zona (15, 16) de acuerdo entre su extremo frontal preferentemente redondeado, y una superficie (16, 17) del fondo del lado del hilo, está situado en el eje (4) central, estando dispuesto el borde (14) del ojo que mira hacia la punta (3) aproximadamente en la prolongación ideal de la ranura (21) para el hilo.
Patent ES-2174791-T3 (ES)
Inventor: ROHM GUNTER HORST
IPC: B23B31/16
Filed: 2000-11-08
Granted: 2002-11-16
Abstract: The tension chuck has a chuck body (3) connected to the chuck flange whilst several clamping jaws (5) are mounted in radial guide grooves (4) of the chuck body. A control bolt (10) and a locking bolt (11) are mounted in the wedge rod (7) adjustable in the axial direction of the chuck body and are mutually adjusted in common in opposite directions by a coupling member (12). The control bolt is adjustable in the direction of the guide groove by a spring and a detent socket (14) in the chuck flange takes up the locking bolt when the control bolt engages in the groove. A resetting member (21) removes the locking bolt from the detent socket when the wedge rod moves into a position for changing the clamping jaw.
Patent ES-2255938-T3 (ES)
Title: Motor de arranque de un motor de combustion interna.
Inventor: SIEMS HANS-DIETER
IPC: F02N11/00
Filed: 2000-11-10
Granted: 2006-07-16
Abstract: Un motor de arranque para un motor de combustión interna, con una carcasa del motor de combustión interna (1) en la que se encuentra un motor de arranque eléctrico (2) y un ensamblaje electrónico (3), que es un componente de un circuito de regulación y/o de control que regula y/o controla el motor de arranque (2) y/o otros componentes del motor de arranque, con al menos un sensor que pertenece al ensamblaje electrónico (3) para el registro de al menos un parámetro de funcionamiento del motor de arranque, caracterizado porque el ensamblaje electrónico (3) se fija en un soporte de la escobilla que mantiene la escobilla de un conmutador (5) del motor de arranque (2), y porque el sensor se conforma como un sensor de temperatura para el registro de la temperatura de la escobilla.
Patent ES-2215610-T3 (ES)
Title: Procedimiento para la obtencion de alcoholes de acetileno y sus productos secundarios.
Inventor: MAAS-BRUNNER MELANIE
IPC: C07C29/17
Filed: 2000-02-22
Granted: 2004-10-16
Abstract: Procedimiento para la obtención de al menos un alcohol insaturado (B), que comprende las siguientes etapas (I) a (III): (I) reacción de al menos un hidróxido alcalino o alcalinotérreo con al menos un alcohol (A) en al menos un disolvente orgánico (L), bajo obtención de una mezcla (G- I), que comprende al menos el alcohol (A), el disolvente (L) y un alcoholato (AL); (II)reacción de al menos un compuesto carbonílico de la estructura general R-CO-R¿ con al menos un alquino de la estructura general R¿¿-CC-H, y la mezcla (G-I), obtenida en la etapa (I), bajo obtención de una mezcla (G-II), que comprende al menos el alcohol (A), el disolvente (L), y un alcohol insaturado (B); (III) destilación de la mezcla (G-II), obtenida en la etapa (II), bajo obtención de al menos un alcohol (B), así como una mezcla (G-III), que comprende el disolvente (L) y el alcohol (A), devolviéndose a la etapa (I) el disolvente (L) obtenido en la etapa (III) y el alcohol (A) obtenido en la etapa (III) como mezcla, caracterizado porque las etapas (I) a (III) se llevan a cabo continuamente.
Patent ES-2204610-T3 (ES)
Inventor: ENSTON ROBERT PETER
IPC: F16K51/00
Filed: 2000-05-22
Granted: 2004-05-01
Abstract: In order to free a seized valve, an inspection port is formed in a wall of the valve body and the areas where the valve is seized are determined. One or more injection ports are formed in the valve body adjacent to the seized portions of the valve, pressurized fluid (preferably an insoluble lubricant having a very high cone penetration) is injected through the or each injection port and the injection ports are then closed.
Patent ES-2262543-T3 (ES)
Inventor: ABE TOSHIHIRO
IPC: F03G7/04
Filed: 2000-10-27
Granted: 2006-12-01
Abstract: A method for improving the efficiency of power generation in a method for power generation comprising forcefully forming an ascending gas flow channel and a descending gas flow channel within a closed zone with a gas sealed therein, generating a whirling flow by the synergistic interaction of both and rotating a turbine by the whirling flow to generate electric power as well as a device for realizing the same. A whirling flow to rotate fans (3,4) is generated by installing a cylindrical rotor (2) between the ascending gas flow channel and the descending gas flow channel. Optionally, a second cylindrical rotor (12) is further installed between the ascending gas flow channel and the partition wall isolating the closed zone from outside so as to reduce the friction between the ascending gas flow and the descending gas flow. And, the present invention is suitable as a method for power generation by utilizing, for example, a temperature difference occurring in nature. <IMAGE>
Patent ES-2239053-T3 (ES)
Inventor: CORMIER MICHEL J N
IPC: A61B17/20
Filed: 2000-12-11
Granted: 2005-09-16
Abstract: A transdermal agent sampling device is provided. The sampling device is comprised of a microblade array and a device for applying a partial vacuum. The microblade array comprises a sheet having a plurality of microblades for piercing the skin to a very shallow depth (i.e., 25 mum to 400 mum) to create microslits in the outermost stratum corneum layer of the skin. The partial vacuum applying device applies a partial vacuum in the range of about 0.1 to about 0.8 atm, and preferably about 0.3 to about 0.7 atm, for sampling a body analyte such as glucose in interstitial fluid. The partial vacuum is applied for a period of about 2 to about 30 seconds, and preferably about 5 to about 15 seconds. The interstial fluid is analyzed for body analyte (e.g., glucose) content or concentration.
Patent ES-2255521-T3 (ES)
Title: Revestimiento.
Inventor: ENTNER REINHARD
IPC: A61K31/5513
Filed: 2000-11-21
Granted: 2006-07-01
Abstract: Un procedimiento para el revestimiento de núcleos de tableta, comprendiendo dicho núcleo de tableta una cantidad eficaz de al menos un compuesto farmacéuticamente activo seleccionado del grupo que consiste en cefuroxima-axetil, cefpodoxima-proxetil, amoxicilina, sumatriptano y olanzapina, que comprende pulverizar una solución o suspensión de revestimiento de una mezcla de revestimiento que consiste en un azúcar, incluyendo alcoholes sacáricos, o un almidón, incluyendo almidones modificados, almidones solubles e hidrolizados de almidón, o una mezcla de un azúcar y un almidón, y opcionalmente en agentes de partición y/o pigmentos y/o agentes colorantes y/o edulcorantes y/o agentes saboreantes y/o agentes humectantes y/o conservantes y/o lubricantes (deslizantes) y/o agentes antiespumantes, sobre las tabletas o los núcleos de tableta, con la condición de que se excluyan los agentes peliculígenos en la solución o suspensión de revestimiento, para obtener tabletas revestidas.
Patent ES-2231349-T3 (ES)
Title: Bomba de vacio.
Inventor: NUMOTO HIRONAO
IPC: F04B33/00
Filed: 2001-07-04
Granted: 2005-05-16
Abstract: Una bomba de vacío incluyendo: un cilindro (14) provisto de una chapa de extremo superior que cubre un extremo superior de dicho cilindro (14) y una chapa de extremo inferior que cubre un extremo inferior de dicho cilindro (14); un pistón (15) para alternar entre una posición superior y una posición inferior en dicho cilindro (14), teniendo dicho pistón (15) una superficie superior y una superficie inferior, y dividiendo un interior de dicho cilindro en dos cámaras (14A, 14B); un eje de pistón (16) conectado a la superficie superior de dicho pistón (15), sobresaliendo dicho eje de pistón (16) hacia fuera de dicho cilindro a través de la chapa de extremo superior de dicho cilindro; una válvula de retención de aspiración (18a, 25a) dispuesta en la chapa de extremo superior de dicho cilindro (14), para permitir que a su través pase aire de aspiración a dicho cilindro, pero que no permite que el aire descargado de dicho cilindro pase a su través; una válvula de retención de descarga (20a, 23a)dispuesta en la chapa de extremo superior de dicho cilindro (14), para permitir que el aire descargado de dicho cilindro pase a su través, pero que no permite que el aire de aspiración a dicho cilindro pase a su través; una válvula de retención de aspiración (18b, 25b) dispuesta en la chapa de extremo inferior de dicho cilindro (14), para permitir que a su través pase aire de aspiración a dicho cilindro, pero que no permite que el aire descargado de dicho cilindro (14) pase a su través; y una válvula de retención de descarga (20b, 23b) dispuesta en la chapa de extremo inferior de dicho cilindro (14), para permitir que el aire descargado de dicho cilindro pase a su través, pero que no permite que el aire de aspiración a dicho cilindro pase a su través.
Patent ES-2248207-T3 (ES)
Inventor: PHAM HOANH NANG
IPC: C01B3/38
Filed: 2001-09-13
Granted: 2006-03-16
Abstract: The present invention is an apparatus arranged to maximize heat utilization for a hydrocarbon steam reforming process to produce synthesis gas. The apparatus comprises a refractory lined vessel with partition walls that divide the inside of the vessel into (1) a combustion chamber(s) containing one or more burners, and (2) convection chambers used as a means to remove combustion products from the combustion chamber through one or more openings at the opposite end of the burner end. The combustion chamber contains one or more reformer tubes in which a mixed-feed of hydrocarbon and steam flow co-current with combustion products and receive direct radiant heat from the combustion flame through the tube wall. The convection chambers contain a tube-in-tube device filled with catalyst in the annuli. The mixed-feed in the annuli flows counter-current with combustion products and the hot product synthesis gas, and thereby substantially lowers the temperature of the combustion and product gases before the gases exit the furnace. High emissivity materials or walls are used inside the convection chambers to enhance the heat transfer from the flue gas to the reformer tubes. <IMAGE>
Patent ES-2250286-T3 (ES)
Inventor: DLUGAS WOLFGANG
IPC: H01B3/30
Filed: 2001-11-07
Granted: 2006-04-16
Abstract: An electric cable comprises one or more layers of a wound polyimide strip (2) which is located between the conductor (1) and the insulating layer (3), with its top and bottom layers bonded to one another by means of a PTFE based material.
Patent ES-2275618-T3 (ES)
Inventor: OGLESBY ALFRED PETER
IPC: F16K31/64
Filed: 2001-12-13
Granted: 2007-06-16
Abstract: A thermally responsive valve (1) for controlling the flow of fuel gas to a gas powered appliance for in turn maintaining the temperature of the gas powered appliance at a substantially constant predetermined temperature within a relatively narrow predetermined temperature range comprises a valve housing (2) defining a valving chamber (5). Fuel gas is delivered through an inlet port (13) to the valving chamber (5) and from the valving chamber (5) through an outlet port (17). A concave bi-metal valving disc (23) in the valving chamber (5) co-operates with a valving element (21) for modulating the flow of fuel gas through the inlet port (13) into the valving chamber (5) in response to the temperature of the valving disc (23). The valving disc (23) is constrained within the valving chamber (5) to prevent the valving disc (25) transitioning between a first configuration and a second configuration at an upper transition temperature of the valving disc (23), thereby causing the valving disc (23) to modulate the flow of fuel gas through the valving chamber (5) with an analog action in response to temperature, rather than a digital action, which would otherwise occur if the valving element (25) were not so constrained.