Patent SG-11201807589R-A (SG)
Title: Delivery of nitric oxide-releasing phospholipids, liposomes, and high density lipoprotein-like nanoparticles (hdl nps) by drug eluting stents and intra-arterial injection
Inventor: THAXTON C
IPC: A61L31/04
Filed: 2017-03-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 September 2017 (14.09.2017) WIPO I PCT omit IIl DID lII 0 °nom im lino 111E1111°111 (10) International Publication Number WO 2017/156078 A3 (51) International Patent Classification: A61L 31/16 (2006.01) A61K 47/24 (2006.01) A61L 31/04 (2006.01) A61K 33/00 (2006.01) A61K 9/51 (2006.01) (21) International Application Number: PCT/US2017/021293 (22) International Filing Date: 08 March 2017 (08.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/305,181 08 March 2016 (08.03.2016) US (71) Applicants: NORTHWESTERN UNIVERSITY [US/US]; 633 Clark Street, Evanston, IL 60208 (US). NANYANG TECHNOLOGICAL UNIVERSITY [SG/SG]; 50 Nanyang Avenue, Singapore 639798 (SG). (72) Inventors: THAXTON, C., Shad; 2431 N. Janssen, Chica- go, IL 60614 (US). RINK, Jonathan; 505 Courtland Av- enue, Park Ridge, IL 60068 (US). VENKATRAMAN, Subbu; N4. 1-02-05, School Of Materials Science And En- gin, Nanyang Technologies University, 50 Nanyang Av- enue, Singapore 639798 (SG). (74) Agent: LOCKHART, Helen, C.; Wolf, Greenfield & Sacks, P.C., 600 ATLANTIC AVENUE, Boston, MA 02210-2206 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, W O 20 17 / 15 607 8 A3 (54) Title: DELIVERY OF NITRIC OXIDE-RELEASING PHOSPHOLIPIDS, LIPOSOMES, AND HIGH DENSITY LIPOPRO- TEIN-LIKE NANOPARTICLES (HDL NPS) BY DRUG ELUTING STENTS AND INTRA-ARTERIAL INJECTION FIG, . Drug. lutinii ants SNO DPPTE NO Liposomes NM_ NPs NO HDL NPs Biodegr; polymet . • COating of bare metal scent [dru g 1 Stilt (57) : Nanostructures having a lipid layer which are useful for delivering nitric oxide are provided herein. Methods of treating disease using the nanostructures are also provided, including methods of treating vascular diseases, angiogenesis, ischemia- reperfusion, etc. Implantable devices coated with the nanostructures are also encompassed within the invention. [Continued on next page] WO 2017/156078 A3 MUNRO DOI 01011MOIDEMOMMONEEHMEfin GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (88) Date of publication of the international search report: 26 July 2018 (26.07.2018)