Patent SG-11201804589T-A (SG)
Title: Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
Inventor: WURTZ NICHOLAS R
IPC: C07D211/76
Filed: 2016-12-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau res., 00) (43) International Publication Date ..... ..sr ,„,„.1 15 June 2017(15.06.2017) WIPO I PCT ID Hit (10) WO 111111111111111111IIIIIIII International II III 2017/100390 IIIIIIIIIIIIIII Publication IIIIIIIIIIIIIIIMIIIIIII Number Al IIIIIIII (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07D 211/76 (2006.01) A61P 9/10 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 31/45 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/US2016/065504 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 8 December 2016 (08.12.2016) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/265,885 10 December 2015 (10.12.2015) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, [US/US]; Route 206 and Province Line Road, Princeton, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, New Jersey 08543 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: WURTZ, Nicholas R.; c/o Bristol-Myers SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Squibb Company, 311 Pennington-Rocky Hill Road, Pen- nington, New Jersey 08534 (US). SHIRUDE, Pravin Sud- Declarations under Rule 4.17: haker; c/o Syngene International Limited, Biocon Special as to applicant's entitlement to apply for and be granted a Economic Zone, Biocon Park, Plot No. 2&3, Bommas- patent (Rule 4.170) Industrial Area IV Phase, Jigani Link Road, Bom- andra masandra, Karnataka, Bangalore 560 099 (IN). — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) (74) Agents: EPPERSON, James et al.; Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, — of inventorship (Rule 4.17(iv)) New Jersey 08543 (US). Published: (81) Designated States (unless otherwise indicated, for every _ with international search report (Art 21(3)) kind of national protection available): AE, AG, AL, AM, (54) Title: PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS Il H .4t 1 - Ar N en O O 1-1 It-- 1-1 (57) : The disclosure relates to compounds of foiinula O peptide 1 (FPR1) receptor agonists. The disclosure also provides for the treatment of atherosclerosis, heart failure, chronic obstructive 0 I, ,,Ar3 NAr 2 \ -j ,„, ( I ) x which are formyl peptide 2 (FPR2) receptor agonists and/or foiinyl compositions and methods of using the compounds, for example, pulmonary disease (COPD), and related diseases.