Patent SG-11201408238W-A (SG)
Title: Substituted tricyclic compounds as fgfr inhibitors
Inventor: WU LIANGXING
IPC: A61K31/4375
Filed: 2013-06-12
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 9 January 2014 (09.01.2014) WIPOIPCT (10) International Publication Number WO 2014/007951 A2 (51) International Patent Classification: C07D 471/14 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/659,245 13 June 2012 (13.06.2012) 61/691,463 21 August 2012 (21.08.2012) 61/740,012 20 December 2012 (20.12.2012) 61/774,841 8 March 2013 (08.03.2013) (74) Agent: GODDARD, Christine A.; Fish & Richardson P.C., P. O. Box 1022, Minneapolis, Minnesota 55440- 1022 (US). PCT/US2013/045309 (81) Designated States (unless otherwise indicated , for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 12 June 2013 (12.06.2013) English English US US us us (71) Applicant: INCYTE CORPORATION [US/US]; Experi­ mental Station, Route 141 & Henry Clay Road, Building E336/207, Wilmington, Delaware 19880 (US). (72) Inventors: WU, Liangxing; 3708 Eastview Lane, Wilm­ ington, Delaware 19082 (US). ZHANG, Colin; 309 Daniel Drive, Ambler, Pennsylvania 19002 (US). HE, Chunhong; 40 Magnolia Way, Chadds Ford, Pennsylvania 19317 (US). SUN, Yaping; 610 Sunflower Circle, Hockessin, Delaware 19707 (US). LU, Liang; 605 Sunflower Circle, Hockessin, Delaware 19707 (US). QIAN, Ding-Quan; 10 Donald Preston Drive, Newark, Delaware 19702 (US). XU, Meizhong; 8 Fritze Court, Hockessin, Delaware 19707 (US). ZHUO, Jincong; 17 Forwood Drive, Garnet Valley, Pennsylvania 19060 (US). YAO, Wenqing; 45 Magnolia Way, Chadds Ford, Pennsylvania 19317 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) — with sequence listing part of description (Rule 5.2(a)) CJ i-H o\ i> o o o CJ (54) Title: SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS (57) Abstract: The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibit­ ors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.