Patent SG-11201804127S-A (SG)
Title: Ctla4 binders
Inventor: PUNNONEN JUHA
IPC: C07K16/28
Filed: 2016-11-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau III111111111111111111111111111111111111111111111111111111111H111111111R111111111111111 (10) International Publication Number WO 2017/087588 Al WIPOI PCT (43) International Publication Date 26 May 2017 (26.05.2017) BOUTTON, Carlo [BE/BE]; Technologiepark 21, 9052 Zwijnaarde (BE). (72) Inventors; and (71) Applicants NZ, US only): DOMBRECHT, Bruno [BE/BE]; Technologiepark 21, 9052 Zwijnaaarde (BE). VICTOR, Bjorn [BE/BE]; Technologiepark 21, 9052 Zwijnaarde (BE). (74) Common Representative: MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (51) International Patent Classification: C07K 16/18 (2006.01) 961% 3 9 / 3 95 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2016/062393 (22) International Filing Date: 17 November 2016 (17.11.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/257,001 18 November 2015 (18.11.2015) US (71) Applicant (for all designated States except US): MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US). (72) Inventors; and (71) Applicants NZ, US only): PUNNONEN, Juha [US/US]; 901 S. California Avenue, Palo Alto, California 94304 (US). BEAUMONT, Maribel [FR/US]; 901 S. California Avenue, Palo Alto, California 94304 (US). (72) Inventors; and (71) Applicants US only): BUYSE, Marie-Ange [BE/BE]; Technologiepark 21, 9052 Zwijnaarde (BE). [Continued on next page] (54) Title: CTLA4 BINDERS 500 96 non—biased healthy human subjects 400 • 300 leve l a t 360 secon ds ( RU) • .• ••• •• 200 100 . % ••••.•• :Is • :::t OOOOO ,„,1„, OOOOO 01.?\"9 4.1.••• 4, 1013700112 F023700912 F023700925 W O 20 17 /0875 88 Al FIG.10A (57) : The present invention provides molecules, such as ISVDs and Nanobodies, that bind to CTLA4 or human serum al - bumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided. WO 2017/087588 Al MIONIM011EMIMOIDE11111111111111111111111111111111111111111111111111111 TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art 21(3)) with sequence listing part of description (Rule 5.2(a)) Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii))