baber/WOPTO huggingface dataset:
Patent WO-2019118475-A1 (WO)
Title: Lymphocytes car-t immortalisés génétiquement modifiés pour éliminer l'expression du récepteur des lymphocytes t et de la bêta 2-microglobuline
Inventor: LEE JOHN
IPC: A61K35/17
Filed: 2018-12-11
Abstract: La présente invention concerne des lignées de lymphocytes T immortalisés modifiés, un procédé pour leur préparation et leur utilisation comme médicament, en particulier pour une immunothérapie. Les lignées de lymphocytes T immortalisés modifiés selon l'invention sont caractérisées en ce que l'expression de récepteurs de lymphocytes T (TCR) endogènes et de la bêta 2-microglobuline (B2M) est inhibée, par exemple, en utilisant une endonucléase apte à inactiver sélectivement les gènes du TCR et de la B2M afin de rendre les lymphocytes T immortalisés non alloréactifs. De plus, l'expression du polypeptide immunosuppresseur peut être effectuée sur ces lymphocytes T immortalisés modifiés afin de prolonger la survie de ces lymphocytes T dans des organismes hôtes. De tels lymphocytes T immortalisés modifiés sont particulièrement appropriés pour des allogreffes, en particulier du fait qu'ils permettent de réduire à la fois le risque de rejet par le système immunitaire de l'hôte et le risque de développement de la maladie du greffon contre l'hôte. La présente invention ouvre la voie à des stratégies d'immunothérapie adoptive standard et abordables faisant appel à des lymphocytes T pour le traitement du cancer, d'infections et de maladies auto-immunes.
Patent WO-2019118734-A1 (WO)
Title: Compositions et méthodes pour traiter des maladies des motoneurones
Inventor: MONANI UMRAO
IPC: A61K38/06
Filed: 2018-12-13
Abstract: La présente invention concerne des compositions et des méthodes de traitement de maladies des motoneurones, notamment l'amyotrophie spinale (SMA) et la sclérose latérale amyotrophique (SLA). Un modulateur d'une protéine de choc thermique, telle qu'une protéine membre de la famille Hsp70, peut être utilisé dans la présente méthode. En variante, une protéine de choc thermique mutante peut être utilisée.
Patent WO-2019133323-A1 (WO)
Title: Système et procédé d'ajustement de groupes de vente pour des magasins
Inventor: KARMAKAR SOMEDIP
IPC: G06Q10/00
Filed: 2018-12-17
Abstract: D'après les informations de transition pour tous les magasins de détail, un score moyen de rétention de groupe est déterminé. Le score moyen de rétention de groupe est une mesure indiquant le nombre de magasins de détail ayant été déplacés du groupe de vente d'origine vers différents groupes de vente existants au cours de la période de vente actuelle. Lorsque le score moyen de rétention de groupe est inférieur à un seuil prédéterminé, une réorganisation complète des groupes de vente existants est effectuée. Lorsque le score moyen de rétention de groupe est supérieur au seuil prédéterminé, il est déterminé si chaque magasin de vente au détail doit être reclassé.
Patent WO-2020139390-A1 (WO)
Inventor: CHEN QI
IPC: B60W30/08
Filed: 2018-12-28
Abstract: Un serveur en communication avec de multiples véhicules peut recevoir des données de ligne de stop ou de céder le passage virtuelle provenant de tels véhicules. Les données de ligne de stop ou de céder le passage virtuelle peuvent correspondre à différents véhicules qui se sont arrêtés au même croisement au même moment ou à des moments différents. Le serveur peut identifier une ligne de stop ou de céder le passage virtuelle représentative à l'aide des données de ligne de stop ou de céder le passage virtuelle reçues, et valider la ligne de stop ou de céder le passage virtuelle représentative à l'aide de données de carte. Après validation, le serveur peut mettre à jour des données de carte pour qu'elles incorporent la ligne de stop ou de céder le passage virtuelle représentative, et transmettre les données de carte mises à jour à un ou plusieurs véhicules pour leur fournir une assistance à la navigation, à la conduite et/ou à la manœuvre à l'avenir.
Patent WO-2019136401-A1 (WO)
Inventor: BANDYOPADHYAY SAIBAL
IPC: A61M39/06
Filed: 2019-01-07
Abstract: The present disclosure provides extracorporeal membrane oxygenation (ECMO) apparatuses treated to comprise lubricating liquid surfaces, hydrophobic or omniphobic surfaces, and/or fluid and solid repellant slippery surfaces that do not stimulate clotting and thrombus formation to the same degree as do the untreated surfaces. The apparatuses permit ECMO procedures to be conducted using less anticoagulant and/or antiplatelet medications than is possible with untreated apparatuses. Also described are methods of using the treated apparatuses to accomplish ECMO procedures on subjects (e.g., human patients) and upon perfused organs.
Patent WO-2020060580-A1 (WO)
Title: Stylet pour dispositifs électroniques
Inventor: RUSCHER JOEL N
IPC: H02J7/02
Filed: 2019-01-08
Abstract: L'invention concerne des dispositifs d'entrée tactile, comme un stylet, pouvant recevoir une entrée tactile d'un utilisateur. Les fonctions d'entrée tactile peuvent être mises en œuvre par un capteur tactile, tel qu'un dispositif de détection capacitif. Un capteur tactile peut être intégré dans un stylet sous une forme compacte. L'invention facilite également une charge sans fil et un couplage magnétique avec un dispositif hôte. Le stylet peut être doté des caractéristiques susmentionnées avec de petites dimensions qui améliorent l'expérience de l'utilisateur du stylet.
Patent WO-2019147899-A1 (WO)
Title: Imaging-directed nanoscale photo-crosslinking
Inventor: CHEN LIN
IPC: C07D249/04
Filed: 2019-01-25
Abstract: A method to induce photo-chemical reactions in a nanoscale space is provided. The method includes fixing cells and incubating the cells with a probe containing a tag for a click reaction. The probe is a psoralen probe that includes an alkyne tag. The method further includes illuminating the cells with UV light on a cell nucleus in a selected region, incubating the cells with a click reaction mix that includes rhodamine-azide, clicking the azide to the psoralen probe through its terminal alkyne, removing excess rhodamine, and viewing the cells with a fluorescence microscope.
Patent WO-2019148092-A1 (WO)
Title: Devices and methods for heating molten material
Inventor: FRALEY RAYMOND EUGENE
IPC: H05B3/03
Filed: 2019-01-28
Abstract: Heating devices can comprise an electrode, a bracket clamped to a rear end portion of the electrode, and a conductive panel comprising an inner face forced toward a rear face of the electrode by the bracket. In further embodiments, methods of assembling the heating device can comprise clamping the bracket to the rear end portion of the electrode and forcing the inner face of the conductive panel toward the rear face of the electrode with the bracket. In further embodiments, apparatus comprising the heating device can comprise a vessel with at least a portion of the electrode received within an opening of at least one wall. In further embodiments, methods can comprise heating molten material within a containment area of the vessel with the electrode and adjusting the position of the electrode relative to the opening of the wall.
Patent WO-2019169154-A1 (WO)
Inventor: GREGORY WILLIAM DAVID
IPC: A61B5/053
Filed: 2019-02-28
Abstract: One embodiment of the present application sets forth a method for predicting recurrence of cancerous cells in a patient that includes measuring, by a first subset of electrodes included in an electrode array operating at a first frequency, a first impedance of a first section of a first sample of tissue excised from the patient, computing a first Cole relaxation frequency for the first section of the first sample based on the first impedance, and generating a first prediction relating to cancerous cells in the patient based at least in part on the first Cole relaxation frequency.
Patent WO-2019173157-A1 (WO)
Title: Conductively-cooled slab laser
Inventor: MUELLER ERIC R
IPC: H01S3/03
Filed: 2019-03-01
Abstract: A carbon dioxide gas-discharge slab-laser is assembled in a laser-housing. The laser-housing is formed from a hollow extrusion. An interior surface of the extrusion provides a ground electrode of the laser. Another live electrode is located within the extrusion, electrically insulated from and parallel to the ground electrode, forming a discharge-gap of the slab-laser. The electrodes are spaced apart by parallel ceramic strips. Neither the extrusion, nor the live electrode, include any direct fluid-cooling means. The laser-housing is cooled by fluid-cooled plates attached to the outside thereof.
Patent WO-2019183010-A1 (WO)
Inventor: BOSWELL EMILY
IPC: A61Q19/08
Filed: 2019-03-19
Abstract: A method of producing a multi-layer beauty care product for applying a skin active agent to the skin. The method involves applying a water-soluble fluid to a transfer substrate. The water-soluble fluid contains a skin active agent and is applied to the transfer substrate through an image carrier having a mesh size of 40 to 500. The water-soluble fluid is dried to form a water-soluble film, which is then transferred to a backing layer coated with a pressure sensitive adhesive. The resulting multi-layer beauty care product provides a suitable a means of delivering the skin care active agent to a target portion of skin.
Patent WO-2019191667-A1 (WO)
Title: Inhibiteurs d'imidazopipérazine de protéines d'activation de la transcription
Inventor: LE KANG
IPC: C07D471/04
Filed: 2019-03-29
Abstract: La présente invention concerne des composés hétérocycliques et des procédés qui peuvent être utiles en tant qu'inhibiteurs de protéines d'activation de la transcription telles que CBP et P300 pour le traitement ou la prévention de maladies telles que des maladies prolifératives, des troubles inflammatoires, des maladies auto-immunes et des maladies fibrotiques.
Patent WO-2019204027-A1 (WO)
Title: Telepresence devices operation methods
Inventor: CUTLER ROSS GARRETT
IPC: H04N7/14
Filed: 2019-04-02
Abstract: A method of operating a telepresence device is disclosed, which includes capturing images of a local subject using a plurality of cameras to generate a plurality of local captured images. Remote subject point of view (POV) data is received from a remote device. A plurality of tiles is selected from the plurality of local captured images based on the remote subject POV data. Local image data is sent to the remote device. The local image data includes the plurality of selected tiles.
Patent WO-2019195786-A1 (WO)
Title: Local metallization for semiconductor substrates using a laser beam
Inventor: LU PEI
IPC: H01L31/0224
Filed: 2019-04-05
Abstract: Local metallization of semiconductor substrates using a laser beam, and the resulting structures, e.g., micro-electronic devices, semiconductor substrates and/or solar cells, are described. For example, a solar cell includes a substrate and a plurality of semiconductor regions disposed in or above the substrate. A plurality of conductive contact structures is electrically connected to the plurality of semiconductor regions. Each conductive contact structure includes a locally deposited metal portion disposed in contact with a corresponding a semiconductor region.
Patent WO-2019199765-A1 (WO)
Title: Optical distribution frames
Inventor: ANKAMAFIO-ADDO DAVID
IPC: H04Q1/14
Filed: 2019-04-09
Abstract: An optical distribution frame defining a coordinate system having a mutually orthogonal longitudinal axis, transverse axis, and lateral axis includes a body extending along the longitudinal axis between a top and a bottom, the body including a front and a rear separated from each other along the transverse axis. The front includes a central portion, a first outer portion, and a second outer portion, the first and second outer portions bordering the central portion and angled inwardly relative to the lateral axis towards each other. The optical distribution frame further includes a first connectivity body disposed on the body, the first connectivity body including a plurality of adapters, and a second connectivity body disposed on the body, the second connectivity body including a plurality of adapters.
Patent WO-2019245635-A1 (WO)
Inventor: GOBAUD DAVID
IPC: G06Q20/00
Filed: 2019-04-12
Abstract: A method includes registering a user account with a digital asset transfer system, receiving from a user of the user account an indication of an amount of digital assets to be purchased by the user, receiving from the user payment for the digital assets to be purchased by the user, and after receiving payment for the digital assets to be purchased by the user, transferring to a digital wallet ledger address associated with the user at least one cryptocurrency corresponding to the digital assets to be purchased by the user.
Patent WO-2019204158-A1 (WO)
Title: System and method for real-time secure multimedia streaming over a decentralized network
Inventor: ALLEN CHRIS
IPC: G06Q20/38
Filed: 2019-04-12
Abstract: The present invention relates to systems and methods suitable for real-time streaming over a decentralized or centralized network. In the decentralized network, the present invention relates to a system and method that utilizes a block-chain distributed network to securely and reliably stream multimedia in real-time. In the centralized network, the present invention utilizes a centralized stream manager to manage nodes within the distributed network to securely and reliably stream multimedia in real-time.
Patent WO-2019210136-A1 (WO)
Title: System and method for abrading surface of plant
Inventor: HENDRIX BILL
IPC: A01N25/12
Filed: 2019-04-26
Abstract: An abrasion device for abrading a surface of a plant includes a sprayer configured to spray abrasive particles toward the surface of the plant so that the abrasive particles abrade the surface of the plant. A track assembly supports the sprayer thereon. The track assembly defines a path along which the sprayer moves as the sprayer sprays abrasive particles toward the surface of the plant.
Patent WO-2019241691-A1 (WO)
Title: Two-factor authentication through ultrasonic audio transmissions
Inventor: THAKKAR NISARG MAHESH
IPC: G06F21/31
Filed: 2019-06-14
Abstract: There is provided systems and methods for two-factor authentication through ultrasonic audio transmissions. A user may utilize a first device request to process a transaction electronically by providing an electronic payment using an online service provider. When utilizing the service provider, authentication for the user's payment instrument and/or the user's account with service provider may require two-factor authentication using a one-time password that is unknown to the user and generated for the specific authentication request. The password may be generated and sent to a second device registered for the user and/or their account. The second device may process an ultrasonic handshake request with the first device, and may respond to the first device with an ultrasonic communication including the password. The first device may then automatically enter the password to the two-factor authentication process.
Patent WO-2020046501-A1 (WO)
Inventor: ROUSSEL ANAÏS
IPC: A61F5/01
Filed: 2019-07-25
Abstract: A thumb brace for at least partially immobilizing a thumb of a user is provided. The thumb brace includes a first curved support element configured to be disposed on a heel of a hand along an intercarp al articulation of the thumb and in a palmar gutter of the hand. The thumb brace includes a second curved support element coupled to the first curved support element and configured to be disposed on a palm of the hand along a metacarpophalangeal joint of the thumb. The thumb brace includes a third curved support element configured to be disposed on a backside of the hand along the intercarpal articulation of the thumb. The thumb brace includes a fourth curved support element coupled to the third curved support element and configured to be disposed on the backside of the hand along the metacarpophalangeal joint of the thumb. Related methods are also provided.
Patent WO-2021021116-A1 (WO)
Title: Barre d'équilibrage de masse variable
Inventor: SCOTT KEVIN M
IPC: G01F1/84
Filed: 2019-07-30
Abstract: L'invention concerne une barre d'équilibrage de masse variable (120-320, 520-820). La barre d'équilibrage de masse variable (120-320, 520-820) comprend un corps d'équilibrage (122-322b, 522-822) contenant un fluide d'équilibrage (124-324b, 524-824), une masse du fluide d'équilibrage (124-324b, 524-824) étant sélectionnée pour équilibrer un conduit de mesure (110-310, 510-810) contenant un matériau de traitement.
Patent WO-2020033462-A1 (WO)
Inventor: WANG HAO
IPC: B32B27/08
Filed: 2019-08-07
Abstract: L'invention concerne un procédé de préparation d'une membrane de toiture thermoplastique, le procédé consistant à (i) extruder une composition comprenant un polymère thermoplastique et une charge minérale pour former un extrudat; (ii) former l'extrudat en une feuille ayant des première et seconde surfaces planes; (iii) laisser la feuille refroidir au moins partiellement; et (iv) traiter mécaniquement la première surface plane de la feuille pour ainsi exposer la charge minérale.
Patent WO-2020076418-A1 (WO)
Inventor: WHITMAN ERIC
IPC: B25J11/00
Filed: 2019-08-15
Abstract: A method for terrain and constraint planning a step plan includes receiving, at data processing hardware (36) of a robot (10), image data (17) of an environment (8) about the robot from at least one image sensor (31). The robot includes a body (11) and legs (12). The method also includes generating, by the data processing hardware, a body-obstacle map (112), a ground height map (116), and a step-obstacle map (114) based on the image data and generating, by the data processing hardware, a body path (510) for movement of the body of the robot while maneuvering in the environment based on the body-obstacle map. The method also includes generating, by the data processing hardware, a step path (350) for the legs of the robot while maneuvering in the environment based on the body path, the body-obstacle map, the ground height map, and the step-obstacle map.
Patent WO-2020046646-A1 (WO)
Inventor: SHAW L
IPC: H01S3/109
Filed: 2019-10-07
Abstract: Fiber optic amplification includes a photonic crystal fiber coupled to a pump laser through a first coupler. The pump laser emits a first electromagnetic radiation wave into the photonic crystal fiber at a first oscillation frequency and a second electromagnetic radiation wave into the photonic crystal fiber at a second oscillation frequency equaling the first oscillation frequency. The first and second electromagnetic radiation waves interact to generate a signal comprising an electromagnetic radiation wave at a third oscillation frequency and an idler comprising a fourth electromagnetic radiation wave at a fourth oscillation frequency to be generated and amplified through parametric amplification. Parametric amplification is achieved by four wave mixing. The photonic crystal fiber emits a parametric output signal based on the four wave mixing. A nonlinear crystal frequency doubles the parametric output signal through second-harmonic generation.
Patent WO-2020046896-A1 (WO)
Inventor: FRY PAUL
IPC: B25F5/02
Filed: 2019-08-27
Abstract: A power tool includes a power tool housing including a fluid inlet and a discharge outlet. A motor is supported by the power tool housing. A tool is configured to be moved relative to the housing by the motor. A fan is configured to be rotated by the motor, such that a fluid flow with debris generated by movement of the tool is drawn into the fluid inlet and through the discharge outlet. A filter is removably attached to the power tool housing. The filter includes a filter media configured to separate the debris from the flow of fluid. The filter media includes a collection container configured to store the debris. The filter also includes an opening in the filter media through which the flow of fluid with the debris enters the collection container, and a valve that is moveable between a closed position and an open position.
Patent WO-2020055976-A1 (WO)
Title: Tert-butyl (s)-2-(4-(phenyl)-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain brd4 inhibitors for treating cancer
Inventor: BLAKE ROBERT ANTHONY
IPC: C07D471/16
Filed: 2019-09-11
Abstract: The present disclosure relates to te rt-butyl (S)-2-(4-(phenyl)-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [l,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain BRD4 inhibitors for treating cancer. Exemplary compounds are e.g. tert-butyl (S)-2-(4-(4-(3-aminoprop-l-yn-l-yl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)acetate (example 1, compound la), tert-butyl(S,E)-2-(4-(4-(3-aminoprop-l-en-l-yl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)acetate (example 6, compound 6a) or tert-butyl(S)-2-(4-(4-(3-(hydroxyamino)prop-l-yn-l-yl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [l,4]diazepin-6-yl)acetate (example 8, compound 8a).Results of biological assays, such as e.g. BRD4 BD1 and BD2 binding (table 2), cell proliferation assays (table 6) and inhibition of MYC expression in MV-4-11 cells (table 7) are disclosed.
Patent WO-2020231459-A1 (WO)
Inventor: ZHANG NING
IPC: H04W48/16
Filed: 2019-09-11
Abstract: Techniques are described for using a dedicated-scan radio to improve scanning and other radio operations performed during wireless communications. The techniques include configuring a dedicated-scan radio to collect and cache scan results without interfering with ongoing wireless communication tasks performed using primary radios. Based on the scan results cached by the dedicated-scan radio, the computing device improves other radio operations in furtherance of wireless communications. Cached scan results enable a primary radio to avoid, or to focus on, scanning certain channels or frequencies during discovering, positioning, or roaming operations. By using the dedicated-scan results as a starting point or seed for functions performed by a primary radio, the computing device may more quickly and more efficiently perform radio functions, minimizing latency to ongoing wireless communications.
Patent WO-2020086207-A1 (WO)
Inventor: PERREAULT JOHN D
IPC: G02B27/00
Filed: 2019-09-25
Abstract: A near-eye display system (100) includes a display panel (102) to emit display light (103) and a lens assembly (106) disposed along an optical axis (108). The lens assembly includes a first phase mask plate (112) having a first major surface (116) facing the display and a second major surface (118) opposite the first major surface, the second major surface implementing a first freeform Fresnel lens structure (124), and further includes a second phase mask plate (114) adjacent and parallel to the first phase mask plate and having a third major surface (122) facing the second major surface and an opposing fourth majors surface (120), the third major surface implementing a second freeform Fresnel lens structure (126). A pose of at least one of the first and second phase mask plates relative to the other is configured to be adjusted to adjust an optical power.
Patent WO-2020069266-A1 (WO)
Title: System and method for visualizing laser energy distributions provided by different near field scanning patterns
Inventor: MARKUSHOV IURII V
IPC: B23K26/00
Filed: 2019-09-27
Abstract: A system and method may be used to visualize laser energy distributions within one or more laser movements generated by a scanning laser processing head. The system and method determine laser energy distributions at a plurality of locations within the laser movement(s) based at least in part on received laser processing parameters and laser movement parameters. A visual representation of the laser energy distributions may then be displayed to allow the user to visualize and select or define the appropriate pattern and parameters for a laser processing operation. The visualization system and method may be used to predict actual laser energy distributions in a laser processing operation by visualizing the laser energy distributions before the laser processing operation and/or to troubleshoot a laser processing operation by visualizing the laser energy distributions after the laser processing operation.