baber/WOPTO huggingface dataset:
Patent EA-000639-B1 (EA)
Title: Novel intermediates and their use to prepare n,n'-bridged bisindolymaleimides
Inventor: FAUL MARGARET M
IPC: A61K31/407
Filed: 1996-11-18
Abstract: 1. A compound of the Formula:   wherein R1 is Br, I, or O-tosyl. 2. A compound of Claim 1 of the formula:   3. A compound of Claim 1 or 2, wherein R1 is Br or I. 4. A pharmaceutical formulation comprising a compound of any one of Claims 1 through 3, and one or more pharmaceutically acceptable carriers, diluents or excipients. 5. A process to prepare an amino substituted N,N'-bridged bisindolylmaleimide of the formula:   wherein R2 is -N(CF3)CH3), -NH(CF3), or -NR3R4 wherein R3 and R4 are independently hydrogen, C1-C4 alkyl, phenyl, benzyl, or combine to the nitrogen to which they are bonded to form a saturated or unsaturated 5 or 6 member ring; which comprises reacting a compound of any one of Claims 1 through 3, with an amine in a non-reactive, polar solvent. 6. A process of Claim 5, wherein the compound is   7. A process of Claim 6, wherein the amine is HN(CH3)2 or H2N(CH3). 8. A process of preparing a N,N'-bridged bisindolylmaleimide of the Formula (V):   which comprises reacting a compound of formula:   with HN(CH3)2 in a non-reactive, polar solvent. 9. The process of preparing a compound of any one of Claims 1 through 3, which comprises converting a compound of the formula:   to a compound of any one of Claims 1 through 3. 10. The process of Claim 9, wherein the process is carried out in the presence of PX3, (phenyl)3PX2or (phenoxy)3PX2 wherein X is bromo or iodo. 11. The process of Claim 10, wherein the process is carried out in the presence of (phenoxy)3PBr2. 12. The process of preparing a compound of the formula (V):   which comprises: (a) Reacting a compound of the formula (IIIa):   with PX3, (phenyl)3PX2, or (phenoxy)3PX2 wherein X is bromo or iodo; to form a compound of the formula (IIa):   wherein R1 is Br or I; and (b) Reacting a compound of formula (IIa) with HN(CH3)2 in a non-reactive, polar solvent. 13. The process of Claim 12, wherein R1 is Br. 14. The process of Claim, 13, which further comprises reacting the compound of formula (V) with CH3S03H. 15. A compound of the formula:   wherein R1 is Br, I, or O-tosyl; whenever prepared by the process of any one of Claims 9 through 11.
Patent EA-006791-B1 (EA)
Title: A valve assembly for opening and closing a fuel line
Inventor: LINDEN SEAN
IPC: F16K17/40
Filed: 2003-06-03
Abstract: The present invention relates to a temperature-sensitive safety valve assembly. The valve assembly comprises a first pressurised fluid region, which region has a first outlet, and a second pressurised fluid region, which region has a heat-sensitive sealing means. A valve between the first and second regions is adapted to be actuated by the pressure of a first pressurised fluid in the first region against biasing means to open the outlet. The heat-sensitive sealing means in the second region fails at high temperature so as to de-pressurise the second region, thereby actuating the valve to move under the biasing means to close the first outlet and seal the first region. The valve assembly comprises a relay unit, which is arranged to sense a parameter, and react to the sensing of the parameter by sealing the first region. The temperature-sensitive safety valve assembly is remotely electronically operable in a wireless manner. Also, the temperature-sensitive safety valve assembly has an electronic device and a solar cell arranged to supply power to the electronic device.
Patent EA-009441-B1 (EA)
Title: Pyrazolopyridines and methods of making and using the same
Inventor: LEE WEN-CHERNG
IPC: A61K31/535
Filed: 2003-09-05
Abstract: Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula (I):
Patent EA-018036-B1 (EA)
Title: Heteroaryl amide derivatives
Inventor: HUTCHISON ALAN J
IPC: A61K31/555
Filed: 2007-11-27
Abstract: The present invention relates to compounds of formulawhere X, Y, W, T, U, V, Z, Zand Zvariables are as described herein. The invention further provides a pharmaceutical composition based on claimed compounds, modulating P2Xreceptor activity and use the compounds for the treatment of a condition responsive to P2Xreceptor modulation.
Patent EA-025700-B1 (EA)
Title: Apparatus and method for quick pain suppression
Inventor: MARINEO GIUSEPPE
IPC: A61N1/34
Filed: 2007-09-18
Abstract: The present invention refers to an apparatus and a method for quick acute and chronic pain suppression, particularly useful and effective towards high-grade pains and/or pains resistant to other analgesic drugs such as opiates. According to the present invention there are generated synthetic "non-pain" information strings of great clinical effectiveness, allowing high reproducibility of the clinical result. Synthesis occurs by combining novel geometries of complex waveforms in a sequence, perceived as "self" and "non-pain" by the CNS.
Patent EA-016902-B1 (EA)
Title: Process for manufacturing a tea product
Inventor: COLLIVER STEVEN PETER
IPC: A23F3/00
Filed: 2009-02-04
Abstract: Disclosed is a process for manufacturing a tea product. The process comprises the step of combining tea juice expressed from a first supply of fresh tea leaves with leaf tea from a second supply of fresh tea leaves and/or with tea solids extracted from the leaf tea. The invention also relates to a tea product manufactured by said process.
Patent EA-017464-B1 (EA)
Title: An adjustable steam injector
Inventor: INNINGS FREDRIK
IPC: B01F25/30
Filed: 2009-01-13
Abstract: The invention relates to an adjustable steam injector (1) of the type which has an injector housing (2) with an inlet (3) for a product which is to be heated and in inlet (5) for steam. The injector housing (2) also has an outlet (4) for the product mixed with steam. The injector (1) also includes an injector body (6) displaceable in the injector housing (2). About the front end of the injector body (6) there are disposed concentric gaps (13, 14) for product and steam, respectively. The injector body (6) has a recess (9) in its front end. The recess (9) has the same extent as the cross sectional surface of the injector body (6) and has its greatest depth in the centre of the injector body (6).
Patent EA-022974-B1 (EA)
Title: Sulfur-linked compounds for treating opthalmic diseases and disorders
Inventor: SCOTT IAN L
IPC: C07C323/32
Filed: 2009-09-02
Abstract: Provided are sulphur-linked compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
Patent EA-021008-B1 (EA)
Title: Inhibitors of the renal outer medullary potassium channel
Inventor: PASTERNAK ALEXANDER
IPC: C07D493/04
Filed: 2010-04-29
Abstract: This invention relates to compounds having structural Formula I and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
Patent EA-023653-B1 (EA)
Title: Method for diagnosing whether patient suffers from multiple hepatic diseases, and method for determining patient's risk with respect to multiple hepatic diseases
Inventor: FLOCH JEAN-FRANCOIS
IPC: G01N33/74
Filed: 2011-01-07
Abstract: The first object of the disclosed invention is method for diagnosing whether a patient suffers from multiple hepatic diseases, where the first hepatic disease was preliminarily diagnosed in the said patient by determining the level of human progastrin (hPG) in a plasma or serum sample of the said patient, at which if threshold value of progastin is at least 400 pM, the said patient is suffering from at least one additional hepatic disease. In addition, described is method for determining patient's risk with respect to multiple hepatic diseases, which includes determination of hPG levels in patient's serum or plasma by means of biochemical analysis and evaluation of relative patient's risk on the basis of the obtained data for one or more hepatic pathologies, where hPG level lower than 100 pM testifies to the fact that the patient is at the "low risk" level for one or more hepatic pathologies; hPG level from 100 to 400 pM testifies to the fact that the patient is at the "high risk" level with respect to presence of cirrhosis with liver cancer or without it and at the "higher risk" level also for presence of hepatitis C, and hPG level higher than 400 pM testifies to the fact that the patient is at the "higher risk" level for presence of liver cancer, cirrhosis and hepatitis C. The patient is also subjected to additional testing with application of other diagnostic means to confirm the fact that the said patient does not have liver cancer, if the said patient has hPG level lower than 100 pM; as well as to additional testing with application of other diagnostic means for liver cancer and/or hepatitis C, if the patient has hPG level from 100 to 400 pM.
Patent EA-021078-B1 (EA)
Title: Electric switching apparatus
Inventor: ALETTI TIZIANO
IPC: H02G3/08
Filed: 2011-02-24
Abstract: The invention relates to an automatic knob-controlled switch (21) comprising a generally box-shaped supporting structure (22) delimiting an inner space (3), and having at least one opening (23) communicating with the inner space and an (Z-Z) opening axis, wherein the opening is defined by an inner edge (23a); a drive mechanism (24) comprising a control knob (25) and means (26) of mechanical connection for connecting the control knob (25) to a supporting structure (22), wherein the means (26) of mechanical connection comprise guide means (26) allowing the control knob to move relative to the supporting structure (22) in the direction substantially parallel to the (Z-Z) opening axis; a key (31) fixed to the control knob manual operation thereof; a protective device comprises a plug(33) arranged between the key and the control knob, the protective device can be used in the supporting structure (22) for interacting with the inner edge (23a) for protecting guide means (26) against the intrusion of dust and similar.
Patent EA-020485-B1 (EA)
Title: Fgf receptor-activating n-acyl octasaccharides, preparation thereof, and therapeutic use thereof
Inventor: DRIGUEZ PIERRE ALEXANDRE
IPC: C08B37/00
Filed: 2010-08-12
Abstract: The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein Ris an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups; Ris an OSO- or hydroxyl group; Ris an alkyl, cycloalkyl, or alky-cycloalkyl group, Ris a disaccharide having Formula (II), Ris a disaccharide having Formula (III); Ris a disaccharide having Formula (IV), where R, R, and Rhave OSOor hydroxyl groups. The invention further relates to the preparation of said octasaccharides and to the therapeutic use thereof.
Patent EA-024800-B1 (EA)
Title: Security device
Inventor: HOLMES BRIAN WILLIAM
IPC: G02B30/27
Filed: 2010-10-27
Abstract: A security device has a lenticular device comprising an array of lenticular focusing elements (2) located over a corresponding array of pairs of image strips (A, B) such that, in a first viewing direction, a first image strip (A) from each pair is viewed by respective ones of the lenticular focusing elements (2) and, in a second viewing direction, different from the first, a second image strip (B) from each pair is viewed by respective ones of the lenticular focusing elements (2). One (A) of each pair of image strips has portions defining a first image in a first colour and a second image in a second colour respectively, and the other (B) of each pair of image strips has portions defining the first image in the second colour and the second image in the first colour respectively, whereby on tilting the device, a colour switch is observed between the first and second images.
Patent EA-025028-B1 (EA)
Title: Process for production of sparkling wines
Inventor: BOTNAR VANDA IVANOVNA
IPC: C12G1/06
Filed: 2013-05-20
Abstract: The invention relates to wine-making industry, in particular to production of sparkling wines made of grape must. According to the disclosed method, provided are grape harvesting and processing; separation of self-flowing must; settling with clarification; preparation of fermenting mixture; open controlled fermenting; additional fermenting under isobaric conditions for grade; stop of fermenting by cooling; soaking at cold; rough and fine filtration; isobaric dispensing. The result is the possibility to preserve organoleptic properties of fresh grapes and surfactants, united properties of foaming and sparkling (bubbling) of high quality in finished product, production of sparkling wine without secondary fermenting.
Patent EA-024758-B1 (EA)
Title: Tricyclic derivatives of n,n'-substituted 3,7-diazabicyclo[3.3.1]nonanes and medicaments based thereon
Inventor: ZAPOLSKY MAXIM EDUARDOVICH
IPC: C07D487/18
Filed: 2012-04-02
Abstract: The invention relates to new tricyclic derivatives of N,N'-substituted 3,7-diazabicyclo[3.3.1]nonanes of formula (1)wherein X is a carbonyl group or methylene group; Ris a fragment (1.1a), (1.2a), (1.3a) or (1.4a), which have the meanings defined herein; R, R'are H, C-Calkyl or C-Calkoxy; R, R', R, R', R, R', R, R', R, R', R, R', Rand R'are H or C-Calkyl. The compounds are capable of allosteric modulation of AMPA receptors, in particular they have nootropic effect, and may be used to treat neurodegenerative pathologies.
Patent EA-027869-B1 (EA)
Title: Stabilized tacrolimus composition
Inventor: SKAK NIKOLAJ
IPC: A61K9/14
Filed: 2011-02-17
Abstract: The invention relates to a stable pharmaceutical composition comprising a solid dispersion of tacrolimus in a vehicle further comprising a stabilizing agent capable of providing a pH below 7 in the composition, as measured after re-dispersion in water, and preventing or reducing the formation upon storage of major degradation products of tacrolimus, in particular the 8-epitacrolimus.
Patent EA-025160-B1 (EA)
Title: Antimicrobial composition
Inventor: CORNMELL ROBERT JOSEPH
IPC: A61K31/05
Filed: 2012-12-05
Abstract: The present invention relates to an antimicrobial composition and a method for disinfection involving the antimicrobial composition. It particularly relates to an antimicrobial composition for personal cleaning, oral care or hard surface cleaning applications. It was found that compositions comprising thymol, p-menthene alcohols and a carrier provide synergistic antimicrobial action. In a preferred aspect the composition also comprises 1 to 80 wt.% of one or more surfactants.
Patent EA-027934-B1 (EA)
Title: N-vinylpyrrolidone and 2-methyl-5-vinylpyridine partially n-oxidized copolymer
Inventor: KEDIK STANISLAV ANATOLIEVICH
IPC: C08F226/10
Filed: 2015-07-20
Abstract: The invention relates to chemistry of heterocyclic compounds and polymers, and also to pharmaceutics and provides an N-vinylpyrrolidone and 2-methyl-5-vinylpyridine partially N-oxidized copolymer of the general formula (I):where a monomeric unit M1 represents a fragment of 2-methyl-5-vinylpyridine (MVP) and a monomeric unit M2 represents a fragment of N-oxidized 2-methyl-5-vinylpyridine (OMVP):the content of monomeric units M1 and M2 (m+k) is 25-90 mol.%, wherein the fraction of monomeric units M2 (k) is 0.05∙(m+k)-0.95∙(m+k), and a medium viscous molecular mass of Mμ copolymer is Mμ=15-250 kDa, expressing immunomodulating activity, having good solubility in water and stability in aqueous solution, and also sufficiently high level of bioactivity.
Patent EA-029194-B1 (EA)
Title: Process for the preparation of comestibles with a chocolate core
Inventor: DOERR TILLMANN
IPC: A23G3/54
Filed: 2013-08-27
Abstract: The present invention relates to improved methods to prepare isomaltulose-containing comestibles with a chocolate core, in particular to prepare coated comestibles with a chocolate core, and to the products obtained thereby.
Patent EA-032141-B1 (EA)
Title: Iodization method and iodine-containing product for use in feeding animals and birds
Inventor: VORONIN SERGEY PETROVICH
IPC: A23K10/40
Filed: 2013-10-11
Abstract: A method for the iodization of an organically-sourced product for use in feeding animals and birds, including a stage for iodization using elemental iodine in an aqueous medium, wherein the iodization can take place in a heterogeneous medium without first converting the organically-sourced product into a soluble state, and wherein the organically-sourced product can be in the form of baker's yeast. The iodization can take place using elemental iodine in an activated state, produced at the moment when iodide ions are oxidized using a specific oxidizing agent, wherein said specific oxidizing agent can be hydrogen peroxide, with at least a threefold molar excess of same. The iodization can take place in an aqueous medium having a pH of between 3.0 and 5.5, and the ratio of parts by weight of aqueous medium and baker's yeast comprises between 1:0.3 and 1:1. The method is carried out in the form of an iodine-containing product which includes iodized baker's yeast containing bound iodine in the quantity of between 0.1 and 2.5 wt.%.
Patent EA-032569-B1 (EA)
Title: USE OF DEXTRAN SULFATE HAVING AN AVERAGE MOLECULAR WEIGHT MFROM 4500 TO 7500 Da FOR INDUCING ANGIOGENISIS IN A SUBJECT
Inventor: WAAS ANDERS
IPC: A61K31/721
Filed: 2015-06-11
Abstract: The present embodiments relate to inducing angiogenesis, in particular to the use of dextran sulfate or a pharmaceutically acceptable salt thereof, having an average molecular weight Mfrom 4500 to 7500 Da for inducing angiogenesis in a subject suffering from a disease, disorder or medical condition causing ischemia in the body of said subject and for increasing blood flow or for vascularizing ischemic tissue in a subject suffering from ischemia and also to corresponding methods. The use of dextran sulfate within the stated range of average molecular weights provides an effective impact on angiogenesis without causing side effects.
Patent EA-036724-B1 (EA)
Title: Mixture of fatty acids and use thereof in the treatment of inflammatory pathologies
Inventor: BURATTIN LODOVICO
IPC: A61K31/20
Filed: 2014-03-04
Abstract: The claimed invention relates to a composition comprising a mixture of at least three fatty acids selected from palmitic acid, oleic acid, stearic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), azelaic acid and myristic acid and at least one physiologically acceptable excipient, preferably N-2-hydroxyethyl palmitamide. The invention also relates to the use of the aforesaid composition in the treatment of inflammatory pathologies.
Patent EA-033652-B1 (EA)
Title: Process for the extraction of silica
Inventor: BENJELLOUN MLAYAH BOUCHRA
IPC: C01B33/00
Filed: 2016-08-18
Abstract: The invention relates to a process for the extraction of silica from lignocellulosic plant matter, comprising the steps of: a) fractionating the lignocellulosic plant matter in the presence of an acid solution, so as to obtain a solid fraction comprising cellulose, b) extracting the silica from the solid fraction obtained in step a) with a basic solution, at a pH between 10 and 13 and at a temperature between 70 and 90°C, so as to obtain a liquid phase comprising silica and a solid phase, c) separating the liquid phase and of the solid phase which are obtained in step b), d) precipitating the silica which is comprised in the liquid phase, at a pH between 5 and 6.
Patent EA-039636-B1 (EA)
Title: Degradable sheet material
Inventor: WALLIS CHRISTOPHER
Filed: 2018-01-08
Abstract: The invention provides a sheet material formed of a degradeable composition, the composition comprising: 30 to 80 wt.% calcium carbonate by weight of the composition; an additive; and the balance a polymer selected from polyethylene, polypropylene and copolymers and blends thereof; wherein the additive comprises, by combined weight of the additive and the polymer: (a) two or more transition metal compounds in a total amount of from 0.15 to 0.6 wt.%, wherein the transition metal compounds comprise a stearate moiety; (b) a mono- or poly-unsaturated C14-C24 carboxylic acid in an amount of from 0.04 to 0.08 wt.%; (c) a synthetic rubber in an amount of from 0.04 to 0.2 wt.%; wherein the two or more transition metal compounds are selected from iron, manganese, copper compounds and wherein the transition metals in the two or more transition metal compounds are different; wherein the transition metals in the two or more transition metal compounds comprise: i) iron, manganese and copper; or (ii) manganese and copper; or (iii) iron and manganese. Furthermore, the invention provides packaging, a container and a disposable coffee cup formed of said sheet material and a method of forming a container, a method of initiating the chemical degradation of said packaging, container and disposable coffee cup and the use of an additive to initiate degradation of a sheet material.
Patent EA-038756-B1 (EA)
Title: PHARMACOLOGICALLY ACTIVE ALICYCLIC-SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES
Inventor: BORZA ISTVAN
Filed: 2018-03-12
Abstract: The invention relates to new pyrazolo[1,5-a]pyrimidine derivatives of formula (I) or pharmaceutically acceptable salts, enantiomers, diastereomers, thereof that serve as GABAB receptor positive allosteric modulators. The invention also relates to a process for producing such compounds. The invention further relates to pharmaceutical compositions comprising such compounds optionally in combination with one or more different therapeutically active auxiliary agents and the use of such compounds in methods for treating disorders associated with the activity of the GABAB receptor positive allosteric modulators. The invention also provides a method for the manufacture of medicaments useful in the treatment of such disorders.
Patent EA-037934-B1 (EA)
Title: Threaded connection for steel pipes
Inventor: MARUTA SATOSHI
IPC: F16L15/04
Filed: 2018-04-11
Abstract: A threaded connection includes a pin (10) and a box (20). The pin (10) includes, in the order from a free end side of the pin (10) toward a tubular body side thereof, an inner sealing surface (11), an inner male threaded portion (12), a shoulder portion (13), an outer male threaded portion (14), and an outer sealing surface (15). The box (20) includes, in the order from a tubular body side of the box (20) toward a free end side thereof, an inner sealing surface (21), an inner female threaded portion (22), a shoulder portion (23), an outer female threaded portion (24), and an outer sealing surface (25). Between the inner sealing surface (21) and the inner female threaded portion (22) of the box (20), an inner groove (16) along a circumferential direction is provided, and some threads of the inner male threaded portion (12) of the pin (10) are contained in the inner groove (16). As a result, sealing performance against internal pressure, external pressure, tensile load, and compressive load can be stably ensured.