baber/WOPTO huggingface dataset:
Patent CN-1303429-A (CN)
Title: TNF受体超家族的成员成熟FLINT(mFLINT)多肽或OPG3的药学应用
Inventor: BUMOL T F
IPC: A61K38/00
Filed: 1999-03-30
Abstract: 成熟的FLINT蛋白(mFLINT)结合FasL和LIGHT,并防止FasL－Fas相互作用介导的编程性细胞死亡和促炎活性,可用于治疗与异常的编程性细胞死亡和炎症相关的疾病。本发明提供了FLINT和成熟FLINT的氨基酸序列和核苷酸序列。公开了表达FLINT的转基因动物的制备和鉴定。也提供了利用mFLINT治疗的治疗组合物和方法。
Patent CR-20130577-A (CR)
Title: Producto de proteínas y proceso para la fabricación de un producto de proteínas a partir de exudado de carne cruda
Inventor: KELLEHER STEPHEN D
IPC: A23L13/60
Filed: 2013-11-06
Abstract: Se refiere a una proteina precipitada obtenida a partir de exudado de tejido muscular animal.
Patent CR-20150471-A (CR)
Title: Procesos e intermedios para hacer un inhibidor de jak
Inventor: LIU PINGLI
IPC: C07F5/04
Filed: 2015-09-10
Abstract: Esta invención se refiere a procesos e intermedios para hacer {1-{1-[3-fluoro-2-(trifluorometil)isonicotinoil]piperidin-4-il}-3-[4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il]azetidin-3-il}acetonitrilo, útil en el tratamiento de enfermedades relacionadas con la actividad de cinasas Janus (JAK) incluyendo trastornos inflamatorios, trastornos autoinmunes, cáncer y otras enfermedades.
Patent CR-20150585-A (CR)
Title: Anticuerpos anti-igf-1r con abolición de la unión al fcrn y su utilización en el tratamiento de enfermedades oculares vasculares
Inventor: HARTMANN GUIDO
IPC: C07K16/28
Filed: 2015-10-22
Abstract: La invención proporciona anticuerpos anti-IGF-1R con abolición de la unión al FcRn y métodos de utilización de los mismos para el tratamiento de enfermedades oculares vasculares.
Patent CR-20160176-A (CR)
Title: Sistema de administración intrauterina
Inventor: AHOLA MANJA
IPC: A61P15/18
Filed: 2016-04-15
Abstract: Método anticonceptivo mejorado que aborda los problemas de las hemorragias iniciales y las hemorragias irregulares asociadas al uso de los sistemas de administración intrauterina. Sistema deadministración intrauterina mejorado.
Patent CR-20210474-A (CR)
Title: Neuregulin-4 compounds and methods of use
Inventor: HEUER JOSEF GEORGE
IPC: C07K14/475
Filed: 2020-03-31
Abstract: The present invention relates to neuregulin (NRG) 4 compounds and methods of treatment with NRG4 compounds.
Patent EC-SP066510-A (EC)
Inventor: EASON STEPHEN WILLIAM
IPC: A61M15/00
Filed: 2006-04-17
Abstract: An inhaler (1) comprising a housing (2) to receive a blister (6a) having a puncturable lid (6c) and containing a dose of medicament for inhalation by a user is disclosed. It comprises a mouthpiece (5) through which a dose of medicament is inhaled by a user, a blister piercing member (7) comprising at least two discrete piercing heads (9) operable to pierce a corresponding number of holes in said blister, an actuator (3) comprising an arm pivotally mounted to the housing at one end, and an opening formed in the vicinity of each piercing head. At least one of said openings forms an airflow inlet into said blister and, at least one other of the openings forming an airflow outlet from said blister. The mouthpiece includes a primary chamber (31) having an outside air inlet (34) in communication, via the primary chamber, with the or each airflow inlet opening and, a secondary chamber (32) in communication with the or each airflow outlet opening. When a user inhales through the mouthpiece, air is drawn through the or each airflow inlet opening into the blister via the outside air inlet and the primary chamber to entrain the dose in the airflow, said entrained dose passing through the or each airflow outlet opening into the secondary chamber of the mouthpiece from where it is carried into the user's airway.
Patent EC-SP993156-A (EC)
Title: Dispositivo de liberacion de emergencia
Inventor: KOCHER HANS
IPC: B66B5/00
Filed: 1999-09-28
Abstract: Se refiere a un dispositivo de liberación de emergencia de accionamiento manual para ascensor de edificio, con una cabina llevada por elementos portantes móviles a través de una polea motriz, estando accionada esta polea motriz por un accionamiento con motor de ascensor freno y con o sin engranajes, estando compuesto el dispositivo de liberación de emergencia de un dispositivo para obtener la conexión efectiva con el accionamiento del ascensor, un elemento de accionamiento de operación manual, medios mecánicos y transmisión y elementos de manejo para el mando remoto de la conexión efectiva con el accionamiento del ascensor.
Patent FI-20000664-A (FI)
Inventor: KIRJAVAINEN KARI
IPC: B29C48/46
Filed: 2000-03-21
Abstract: A method and an apparatus for extruding material, the material being extruded with an apparatus comprising at least one rotatable rotor and at least one stator, the rotor and the stator comprising grooves, whereby the grooves make the material move through the apparatus when the rotor is rotated. The rotor and stator surfaces facing each other have a wavelike cross-section, and the grooves are so arranged that at the ridge of a wave the depth of a groove reaches its maximum, and at the bottom of a wave the depth reaches its minimum. The bottom of the wave in the rotor is at the ridge of the wave in the stator and vice versa. This makes the material move alternately from a rotor groove to a stator groove, and back.
Patent GB-1051257-A (GB)
IPC: G11C11/06
Abstract: 1,051,257. Magnetic storage apparatus. RADIO CORPORATION OF AMERICA. Aug. 28, 1963 [Sept. 28, 1962], No. 34085/63. Heading H3B. Individual cores 10 of a matrix are housed edgewise, as shown, in sockets 22 in a sheet 20 of insulating material and are connected (i) in rows by printed conductors 12, 14, 16 linking their faces and 24 on a surface of the sheet, and (ii) in columns by wires 26. The sockets may be punched or photo-etched. The printed conductors may be formed by, say, vacuum metallization, spraying, painting and firing, or by etching away unwanted parts of a conductive layer. Electrical connection between the cores and the conductors 24 may be established by electroplating (which may be preceded by electroless plating) or by dip soldering. All the conductors 24 may be temporarily connected by a conductive material (e.g. toluene soluble silver paste or a conductive tape) which is removed after plating. The wires 26 bear insulation, or are insulated from the printed conductors by the prior application of an insulating coating to the latter. The cores may be positioned in the sockets by a funnelling member and pressed into place, or may be loaded directly into the sockets by a shaker table and vacuum apparatus in communication with the socket bottoms.
Patent GB-1051507-A (GB)
IPC: H01L21/762
Abstract: 1,051,507. Semi-conductor devices. TELEFUNKEN PATENTWERTUNGS G.m.b.H. Sept. 10, 1965 [Oct. 14, 1964], No. 38655/65. Headings H1K. A method of producing a plurality of monocrystalline regions 4 embedded in a substrate 6 for use in solid-state circuits comprises providing an insulating layer 2 on the face of a monocrystalline semi-conductor wafer 1 and covering this with a support layer 3, Fig. la (not shown), selectively etching recesses in the wafer 1 to produce isolated regions 4, Fig. lb (not shown), covering regions 4 with an insulating layer 5 and a substrate layer 6, Fig. 1c, and then removing support layer 3 by selective etching, Fig. 1d (not shown). The monocrystalline semi-conductor material may be silicon, insulating layer 2 may be silicon oxide produced by thermal oxidation of wafer 1, and support layer 3 may be of polycrystalline silicon precipitated from the gas phase. The thickness of wafer 1 may be reduced from below and is etched as far as insulating layer 2 using a photo-masking technique. Substrate 6 may be of polycrystalline silicon or an insulating material such as quartz, glass, or ceramic. and may also comprise a series of layers, e.g. a passivating layer, a layer with low permittivity, and finally a layer with high thermal conductivity. Substrate 6 may be produced by precipitation from the gas phase, by vapour deposition in vacuo, by sintering, or by alternately precipitating semiconductor material from the vapour phase and converting the grown layer into an oxide. The lower face of substrate 6 may be lapped flat before removing support layer 3 and if it is of insulating material it may be coated with semiconductor material to facilitate soldering. Layer 2 may also comprise a plurality of layers and may be reinforced with one or more insulating layers after removal of layer 3. Semi-conductor wafer 1 may be provided with one or more epitaxial layers. A circuit comprising a planar transistor diffused into a region 4 and connected by a vapour deposited contact 9<SP>1</SP> which extends over insulating layer 2 to a thin film resistor 11 is described, Fig. 2 (not shown).
Patent GB-1053548-A (GB)
IPC: C14B5/00
Abstract: 1,053,548. Cutting-out presses. BRITISH UNITED SHOE MACHINERY CO., and M. SALWAY-WALLER. Oct. 1, 1963 [Oct. 2, 1962], No. 37261/62. Heading B4B. In a cutting-out press similar to those disclosed in Specifications 764,634 and 794,979, the relative movement of separation between the bed and presser member is automatically terminated after a predetermined, but adjustable, period of time thereby to adjust the separation between the bed and presser member. As shown in Fig. 1, fluid-pressure operated means is provided for reciprocating a beam 16 towards and away from a bed 10, a valve V of the fluid-pressure operated means being controlled by solenoids SOL 1 and SOL 2. The beam and bed are provided with electricallyconductive portions 70, 72 respectively. The solenoids are included in an electric circuit, Fig. 2, comprising R1, R2, manually-operable switches SW1, SW2, thyratrons 66, 68 associated with an adjustable timer TD and an adjustable time-delay device comprising thyratrons 90, 92, a capacitor C7 and an adjustable resistor POT 1. When both switches SW1, SW2 are operated, relay R1 is energized in addition to relay R2 so that both solenoids SOL 1 and SOL 2 are energized to initiate movement of the beam towards the bed. As disclosed in Specification 794,979, when the cutting edge portion of die 14 penetrates sheet material 20 on the bed, thyratron 66 fires and after a time-delay determined by timer TD, thyratron 68 fires and relay R2 is de-energized to de-energize solenoid SOL 2. Valve V is thereby operated to initiate return movement of the beam. The thyratron 68 is in parallel with a normally-open switch PS which if closed during the movement of the beam towards the bed will de-energize relay R2. Operation of the thyratron 68 or of the switch PS acts to trigger the time-delay device. Thyratron 90 fires and after a time interval determined by resistor POT 1 and capacitor C7, thyratron 92 fires to de-energize relay R1 and hence solenoid SOL 1 to terminate the return movement of the beam.
Patent GB-1053681-A (GB)
IPC: B32B27/00
Abstract: 1,053,681. Laminates. UNITED STATES RUBBER CO. March 2, 1965 [April 6, 1964], No. 8776/65. Heading B5N. [Also in Division C3] Cellulose acetate sheeting is adhered to sheets of an elastomer by the inclusion in the latter of (a) a vulcanizing agent and (b) a combination of chemicals, one from each of a group (i) and (ii), and heating the contacted sheets to effect vulcanization and bonding. Elastomers usable include natural rubber; synthetic rubbers such as polybutadiene, polyisoprene and their copolymers with styrene and acrylonitrile; isobutylene-isoprene copolymers; terpolymers of ethylene and propylene with dicyclopentadiene, 1,4-hexadiene, cyclooctadiene, and dicyclooctadiene; ethylene-propylene elastomeric copolymers; and fluorocarbon elastomers such as copolymers of vinylidene fluoride or nitrosotrifluoromethane with hexafluoroprene or chlorotrifluoroethylene. Vulcanizing agents include sulphur-containing materials and peroxides. Group (i) chemicals include resorcinol, m-aminophenol, m-phenylenediamine, resorcinol acetates, 1,5-naphthalenediol, partially reacted resorcinol-formaldehyde resin, and other resorcinol-aldehyde condensation products. Group (ii) chemicals comprise trimeric methylaminoacetonitrile or the nitrogen-containing compounds the subject of Specifications 959,529, 962,050, 966,943 and of other prior applications (an extensive list is given). In examples compositions (1)-(3), see below, were sheeted out and cured against sheets of cellulose acetate for 30 minutes at 320‹ F. (1) SBR, silica, zinc oxide, coumarone-indene resin, vulcanizing ingredients, Group (i) chemical (4,41-isopropylidenediresorcinol), Group (ii) chemical (3,7 - Dioxa - 1 - aza - 5 - methylolbicyclo[3,3,0]octane. (2) Vinylidene fluoridehexafluoropropene copolymer, Groups (i) and (ii) chemicals as in (1), dicumyl peroxide. (3) SBR and compounding ingredients as in (1), methyleneaminoacetonitrile trimer, resorcinol-formaldehyde resin.
Patent GB-1054134-A (GB)
IPC: H03F3/21
Abstract: 1,054,134. Transistor amplifiers. GENERAL ELECTRIC CO. Ltd. March 1, 1965 [Feb. 28, 1964], No. 8409/64. Headings H3T and H4R. A transistor amplifier circuit comprises a plurality of networks including at least one transistor the networks being connected in series as far as the supply of direct current to operate the transistors is concerned and connected in parallel as far as the transmission of an alternating current signal through the arrangement is concerned. As shown (Fig. 1) three transistors 1, 2, 3 are arranged in series across the supply lines 4, 6 and biased such that each transistor has a similar collectoremitter potential. A signal is applied equally to all three bases and the output signal from the transistor applied to the primary of transformer 28. The emitter signal paths for the transistors formed by capacitors 7, 12, 16 in series with resistors 8, 13, 17 respectively also apply negative feedback to the transistors. Inductors 9 and capacitors 11, form a power separating low-pass filter as do inductor 14 and capacitor 15. Fig. 2 (not shown) illustrates the amplifier in use in a line communication system (Division H4) wherein the input signal is applied by a transformer 41 the primary of which serves to carry current from a constant current source provided in terminal apparatus to which the amplifier is connected. The current is taken from a tap on the primary, through an inductor 46, a Zener diode 47 and a further coil to a tap on the secondary of the transformer fed by the amplifier.
Patent GB-1084186-A (GB)
IPC: C01B25/22
Abstract: 1,084,186. Filters for liquids. MONTECATINI SOCIETA GENERALE PER L'INDUSTRIA MINERARIA E OHIMICA. June 29, 1965 [June 30, 1964], No. 27549/65. Heading B1D. In apparatus for obtaining a solid from a slurry and washing the solid one or more times, there are provided filters exceeding in number the number of washings by two, the filters being fixed during filtration and washing, means for feeding with slurry, means for feeding with wash liquid, and means for effecting discharge of the solid in continuous cyclic succession at each filter in such a way that the filters, while in operation simultaneously, are at any one time each at a different stage of the cycle. As shown, unfiltered slurry A, fresh wash solvent B, solvent which has passed once through filter cake W 1 , and solvent which has passed twice through filter cake, W 2 , are received in separate compartments in a rotary vessel D of a feeder-distributor 1, items W 1  and W 2  having been returned from a collector-separator 3. Filtrate Y is discharged, while "third washings" Z are discarded from the collector separator 3. The feeder distributor 1 includes five fixed vessels with valved outlets, fed via annular channels from D in a five-part cycle so that each vessel receives four feeds sequentially - slurry, "second washings" W 2  "first washings" W 1 , fresh wash solvent - and then no feed, the vessels being in different phases at any one time. These feeds are passed on to four of the five filters F1 - 5, filter F5, for example, receiving no feed and being tilted to discharge its cake and liquids V 1  - V 4  being extracted by vacuum from the remaining four filters and passed on to the collector-separator 3. The collector-separator 3 may similarly consist of a rotary compartmented vessel, annular channels, and four fixed vessels, each receiving one liquid only. In an alternative form of the feeder-distributor 1, four fixed vessels, each fed by one of the influent liquids, supply the five filters distributively through an assemblage of 20 valved pipes. In an alternative form of collector-separator 3, five filter outlet pipes, (one empty at any one time), supply, through an assembly of 20 valved pipes, four fixed vessels, each receiving one liquid only whatever form the apparatus parts 1 and 3 may take, all vessel rotations, valve changes and tilting of the filters are under the control of a timer 4. Preferably each filter element consists of an open tray with a filtering cloth supported on a grating, and vacuum-and liquidcollecting connections (Fig. 6, not shown). The filter element is pivoted to an inverted position to discharge cake jets of water then washing their upstream surfaces, the tray pivoting only half way. Thus, in the complete apparatus, means are provided for recycling the wash liquid a number of times which is less by one than the number of washings, in such a way that solid about to be discharged receives fresh wash solvent, while solid just filtered from slurry receives wash liquid about to be discarded.
Patent GB-1228607-A (GB)
IPC: A21C11/16
Filed: 1968-11-18
Abstract: 1,228,607. Extruding potato-dough. L. J. ILINES. 18 Nov., 1968 [26 Dec., 1967], No. 54538/68. Heading B5A. A potato-dough mixing and extrusion machine is similar to that described in Specification 1,152,747, but is of generally simplified form, the cutting mechanism being rotary and comprising a wheel 33, Fig. 3, having spokes 36 which cut dough extruded through orifices 31 in die plate 30 when the wheel is rotated by means of handle 38. Wheel 33 is supported on flanges 42 within a retaining ring 39 and rotation of the wheel is limited by a slot 44 through which handle 38 extends. Retaining ring 39 also accommodates die 30, recess 49 thereon engaging a rib 48, and the ring press-fits on to extrusion cylinder 25. The latter is optionally provided with an inwardly extending flange 26, Fig. 2. The extrusion piston 27 has sealing means comprising a skirt 28 which flares outwardly in the extrusion direction. The mixing of the dough is performed using piston 27 as a seal for one end of cylinder 25, see Fig. 4a (not reproduced), the cylinder being fitted with the die and cutter and then inverted after mixing, see Fig. 4b (not reproduced). Preferably the cylinder, piston, die and cutter are made by injection moulding using as a preferred material acrylonitrile - butadiene - styrene.
Patent GB-1229398-A (GB)
IPC: E04G17/04
Filed: 1969-08-26
Abstract: 1,229,398. Wall shuttering. FORM-SCAFF (PTY) Ltd. 26 Aug., 1969 [29 Aug., 1968], No. 42538/69. Heading E1S. Shuttering panels are each framed with outwardly-directed channel sectioned members 4 to which the facing sheet 2 is attached via one flange of each member, and a series of spirallyshaped holes 10 are formed along the free edges of each member, in alignment in each pair of flanges. The holes 10, when two such panels are placed in edge-to-edge relationship, form a hole with a round central portion which can receive a round tie bar with co-linear slots extending on oposite sides to receive a rectangular tie bar. Rectangular perforations 9 are provided in the webs for locking members (Figs. 5, 6, not shown) to be passed therethrough and through the rectangular tie rods. Shutter ferrules (12), (Fig 7, not shown) may be used to locate the panels relative to a round tie rod, and additional securing members for adjacent panels may be used, in the form of U-shaped members 15 and wedges 17.
Patent GB-1230471-A (GB)
IPC: B22D27/06
Filed: 1968-03-07
Abstract: 1,230,471. Casting processes. FOSECO TRADING A.G. 26 Feb., 1969 [7 March, 1968] No. 11134/68. Heading B3F. [Also in Division C3] Horizontal exposed molten metal surfaces are thermally insulated by applying thereto a mat comprising 10 to 20% by weight of a bonded refractory fibrous material. The preferred slab composition is refractory fibrous material .... 10-15% organic fibrous material ...0-20% binder ..... 1-20% particulate refractory filler .. balance. The slabs are manufactured by vacuum dewatering of a slurry composition followed by stoving to drive off remaining water. The slabs can be used to cover molten metal in ingot moulds after a layer of anti-piping compound has been spread on the metal surface. If desired a layer of exothermic compound can be coated on one side of the slab. The slabs can also be used for heat insulating molten metal in the tundishes of continuous casting machines.
Patent GB-1230475-A (GB)
IPC: F01C1/344
Filed: 1968-11-13
Abstract: 1,230,475. Rotary motors. GAS COUNCIL. Nov.12, 1969 [Nov.13, 1968], No.53771/68. Heading F1F. A reversible gas-driven motor of the sliding vane kind having a cylindrical chamber 11, provided with a pair of inlet ports 20, 21 and an eccentric rotor 12 provided with a plurality of radicallysliding vanes, 13 includes a double-wallet easing 10 sub-divided into an inlet manifold 14 and an outlet manifold 15 and having in its inner wall a pair of radical ports 25 co-operable with the inlet ports 20, 21 and a plurality of radical ports 24 co-operable with a corresponding member circumferentially spaced vent apertures 17 through the chamber 11. A handle 23 fixed to the casing 10 permit rotation of the casing relative to the chamber to reverse the motor, vary its speed and control the opening and closing of the vent apertures 17. In the position shown, inlet ports 20 is open and inlet port 21 closed so that rotor rotates anti-clockwise. Vents 17 on the driving side of the chamber 11 are closed whilst the remainder remain open to prevent any re-comporession of the exhausting gas. On movement of the handle 23 clockwise port 20 is closed and port 21 opened with the rotor then rotating clockwise and the previously open vents 17, now on the driving side of the chamber, closed and the other vents open. An annular seal 22 of P. T. F, E, fixed either to the casing or chamber is interposed between the casing and chamber.
Patent GB-1232907-A (GB)
IPC: G04C13/11
Filed: 1969-11-04
Abstract: 1,232,907. Electric timepieces. SUWA SEIKOSHA K.K. Nov.4, 1969 [Nov.5, 1968], No.54038/69. Heading G3T. An electronic timepiece comprises a driving device including a pulse generator 34 controlled by a time standard oscillator 35, a stepping motor rotated unidirectionally by the pulse generator 34 and having a rotor 24 including at least two pairs of magnetic poles of opposite polarity, stators 21, 32 each having at least one pair of poles, and a gear train for driving the second hand 29 and comprising a pinion 28 meshing with a gear-wheel 30 provided with an indexing mechanism, e.g. comprising an indexing wheel 31 having teeth engageable by a spring pawl 32, whereby the gear train absorbs by backlash the vibrations produced by each step of the rotor.