Patent ES-2375673-T3 (ES)
Inventor: GREAVES ANDREW
IPC: A61K8/49
Filed: 2008-09-18
Granted: 2012-03-05
Abstract: Substituted hemicyanine styryl thiol/disulfide compounds (A) and their organic or mineral acid salts, optical and geometrical isomers, solvates or hydrates, useful as fluorescent dye, are new. Substituted hemicyanine styryl thiol/disulfide compounds (A) of formula (I) and (II) and their organic or mineral acid salts, optical and geometrical isomers, solvates or hydrates, useful as fluorescent dye, are new. Either R1a, R1b : H or 1-4C alkyl; and R 1>H, 1-6C alkyl (optionally substituted by halo, 1-4C alkoxy, 1-4C di(alkyl)amino, phenyl, tolyl or methoxyphenyl); or R1aR 1>3-6C alkylene chain or 3-7C alkenylene chain; either R 2>, R 3>H, halo, (1-6C)alkyl (optionally substituted), 1-6C alkoxy or 1-6C alkylthio; or CR 2>R 3>benzocycle (optionally substituted); either R 4>, R 5>, R 6>H, 1-6C alkyl (optionally substituted by one or more radicals comprising OH, 1-2C alkoxy, 2-4C poly-hydroxyalkoxy, acylamino or amino substituted by one or two 1-4C alkyl radical), halo, OH, 1-2C alkoxy, 1-2C alkylthio, amino radical, 5 or 6 membered heterocycloalkyl (substituted by 1-3 groups of OH, amino, (di)alkylamino or 1-4C hydroxyalkyl), amino radical (substituted by two 1-6C alkyl radical and containing OH or amino group optionally substituted by one or two 1-3C alkyl radical, where the alkyl radical forms nitrogen atom to which it is attached, or 5-7 membered heterocycle (optionally saturated, substituted and comprising one or more heteroatom different form N)), NR2g-CO-R1g, carboxylic radical that forms acid or salt, or polyhaloalkyl comprising 1-6C and 1-6 atoms of halo; or CR 4>R 5>, CR 5>R 6>benzocycle or fused heterocycle substituted by phenyl; or R 4>R 5>R 6>together with the phenyl group of (II) : tricyclic julolidine group of formula (Q); R1c, R1d : H or 1-4C alkyl; R2g : H or 1-4C alkyl optionally substituted by OH; R1g : 1-2C alkyl; L : 1-20C bivalent hydrocarbon chain (optionally substituted and interrupted by: one or more divalent groups comprising NR, N +>RR 0>, An ->, O, S, CO and/or SO 2, or cationic heterocycle or cationic heteroaryl (Het +>An ->)); Het +>5-10 membered heterocycle (optionally saturated) or 5-10 membered heteroaryl; R, R 0>H, 1-4C alkyl, OH or aminoalkyl; X : O, S or NRbb; Rbb : H or 1-6C alkyl; Y 1>H, alkaline metal, alkaline-earth metal, ammonium group of formula ((N +>Ralpha Rbeta Rgamma Rdelta )(An ->)), phosphonium group of formula ((P +>Ralpha Rbeta Rgamma Rdelta )(An ->)) or thiol-protection functional group; Ralpha , Rbeta , Rgamma , Rdelta : H or 1-4C alkyl; W 1>O, S or NRaa; Raa : H or 1-4C alkyl; Q ->, An ->anionic counter ion; n : 1 or 2; and m : 0 or 1. Provided that when n is 2 then m is zero, and when n is 1 then m is 1. Independent claims are included for: (1) a dye composition comprising a fluorescent dye compound (A) in a cosmetic medium; (2) a method of coloring of keratin fibers, comprising applying the composition comprising (A) on keratin fibers; and (3) multi-compartment device comprising a first compartment containing a dye composition; and a second compartment containing a reducing agent. [Image] [Image].