Patent SG-11201909442V-A (SG)
Title: Tangential flow filtration device for perfusion applications
Inventor: DUPONT ALISON
IPC: C07K1/34
Filed: 2018-05-25
Abstract: RESIDUEFLOW O N N N O 1-1 N C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 06 December 2018 (06.12.2018) WIP0 I PCT ~~~~~ 11111111011101010VIIIOH olo om om Em ioo lio Elio ow (10) International Publication Number WO 2018/222550 Al (51) International Patent Classification: C12M 1/00 (2006.01) CO7K 1/34 (2006.01) BOLD 63/10 (2006.01) Cl 2M 1/26 (2006.01) (21) International Application Number: PCT/US2018/034709 (22) International Filing Date: 25 May 2018 (25.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/513,793 01 June 2017 (01.06.2017) US (71) Applicant: EMD MILLIPORE CORPORATION [US/US]; 400 Summit Drive, Burlington, MA 01803 (US). (72) Inventor: DUPONT, Alison; 161 Old Temple Road, Lyn- deborough, NH 03082 (US). (74) Agent: BALICKY, Eric, M. et al.; Hamilton, Brook, Smith & Reynolds, P.C., 530 Virginia Rd, P.O. Box 9133, Con- cord, MA 01742-9133 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (54) Title: TANGENTIAL FLOW FILTRATION DEVICE FOR PERFUSION APPLICATIONS FIG. 1 (57) : Filter elements (20, 100) for perfusion systems and methods are provided. A filter element sheet includes a microporous membrane (63, 112) having a mean pore size of at least about 0.651,1m and a feed spacer (25, 120) comprising woven fibers and having an open area of at least about 35%. The filter element sheet can be arranged within a filter element, for example, in a spiral-wound format or in a cassette format. A perfusion system includes at least one filter element and a pump configured to control flow of a liquid feed through the at least one filter element. [Continued on next page] WO 2018/222550 Al MIDEDIM011010EIRDERI0010110111111111101101111111111111111111 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))