Patent SG-11201910206Q-A (SG)
Title: Methods and compositions for treating inflammatory gastrointestinal disorders
Inventor: BEBBINGTON CHRISTOPHER ROBERT
IPC: A61K39/395
Filed: 2018-05-04
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT omit VIII °nolo III VIII VIII IID No oimIE (10) International Publication Number WO 2018/204871 Al (51) International Patent Classification: A61K 39/395 (2006.01) A61P 37/00 (2006.01) A61P 1/00 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/031231 (22) International Filing Date: 04 May 2018 (04.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/502,480 05 May 2017 (05.05.2017) US 62/572,337 13 October 2017 (13.10.2017) US (71) Applicant: ALLAKOS INC. [US/US]; 75 Shoreway Road, Suite A, San Carlos, California 94070 (US). (72) Inventors: BEBBINGTON, Christopher Robert; c/o Al- lakos Inc., 75 Shoreway Road, Suite A, San Carlos, Cali- fornia 94070 (US). YOUNGBLOOD, Bradford Andrew; c/o Allakos Inc., 75 Shoreway Road, Suite A, San Car- los, California 94070 (US). TOMASEVIC, Nenad; c/o Al- lakos Inc., 75 Shoreway Road, Suite A, San Carlos, Cali- fornia 94070 (US). BROCK, Emily C.; c/o Allakos Inc., 75 Shoreway Road, Suite A, San Carlos, California 94070 (US). (74) Agent: JONES, Kevin; Morrison & Foerster LLP, 755 Page Mill Road, Palo Alto, California 94304-1018 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY GASTROINTESTINAL DISORDERS Blood Eosinophils me PBS + No OVA izotypo + ovA ssm Anti-Siglec-8 Ats + OVA N cc O 00 O C Tissue Eosinophils Tissue Mast Cells Small intasttna Bolan Intestine (57) : The present disclosure provides methods for the treatment of inflammatory bowel disease (IBD) or an eosinophilic gas- trointestinal disorder (EGID), such as eosinophilic esophagitis (EOE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC). In particular, the present disclosure provides methods for the treatment of IBD or an EGID through ad- ministration of antibodies that bind to human Siglec-8 or compositions comprising said antibodies. The present disclosure also provides articles of manufacture or kits comprising antibodies that bind to human Siglec-8 for the treatment of IBD or an EGID. [Continued on next page] WO 2018/204871 Al MIDEDIMOMOIDEIRDERI0010101111NOMHIMEMOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to non prejudicial disclosures or exceptions to lack of novelty (Rule 4.17(v)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))