Patent EP-4019051-A1 (EP)
Inventor: COMBA PETER
IPC: A61K103/40
Filed: 2020-12-22
Abstract: The invention relates to a compound of general formula Iin whichX is selected from consisting of a first group, a second group or a third group, wherein the first group consists ofthe second group consists ofand the third group consists ofY is a group of general formula II or of general formula IIIif X is selected from the first group, Z is selected from a first group consisting ofif X is selected from the second group, Z is selected from a second group consisting ofif X is selected from the third group, Z is selected from a third group consisting ofR<sup>1</sup> and R<sup>2</sup> independently are selected from the group consisting of a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkyl group, a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> heteroalkyl group, -C(O)-O-R<sup>a</sup>, -C(O)-NR<sup>b</sup>R<sup>c</sup>, -C(O)-C(R<sup>a</sup>)<sub>2</sub>-NR<sup>b</sup>R<sup>c</sup>, and -C(O)-NR<sup>b</sup>-(CH<sub>2</sub>)<sub>n</sub>-C(O)-O-R<sup>a</sup>, wherein R<sup>a</sup>, R<sup>b</sup> and R<sup>c</sup> each independently are selected from the group consisting of hydrogen, a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkyl group, a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> heteroalkyl group, a substituted or unsubstituted aryl group and a group L and n is an integer from 1 to 10;R<sup>3</sup> is selected from the group consisting of oxygen, sulfur, =NR<sup>d</sup>, and =CHR<sup>d</sup>, wherein R<sup>d</sup> is selected from the group consisting of hydrogen, a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkyl group, a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> heteroalkyl group, a substituted or unsubstituted aryl group, -O-R<sup>e</sup>, -C(O)-O-R<sup>e</sup>, -C(O)-NR<sup>f</sup>R<sup>g</sup>, and a group L, R<sup>e</sup> is hydrogen or a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkyl group, and R<sup>f</sup> and R<sup>g</sup> each independently are hydrogen or a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkyl group; andR<sup>4</sup> is selected from the group consisting of -OR<sup>h</sup>, -SR<sup>h</sup>, -NHR<sup>h</sup> and -CH<sub>2</sub>R<sup>h</sup>, wherein R<sup>h</sup> is selected from the group consisting of hydrogen, a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkyl group, a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkenyl group, a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkynyl group, a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> heteroalkyl group, a substituted or unsubstituted aryl group, -C(O)-(CH<sub>2</sub>)<sub>m</sub>-R<sup>k</sup>, -C(O)-(CH<sub>2</sub>)<sub>m</sub>-NR<sup>m</sup>R<sup>n</sup>, a group -A-L and a group L, R<sup>k</sup> is selected from the group consisting of a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkyl group, a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> heteroalkyl group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted carboxy group, R<sup>m</sup> and R<sup>n</sup> each independently are hydrogen or a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkyl group, and m is 0 or an integer from 1 to 10;R<sup>5</sup> and R<sup>6</sup> independently are selected from the group consisting of hydrogen, chloro, bromo, iodo, and O-R<sup>o</sup>, wherein R° is a substituted or unsubstituted C<sub>1</sub>-C<sub>6</sub> alkyl group;A is a linker group andL is an amino acid residue or a peptide.