baber/WOPTO huggingface dataset:
Patent WO-2021113212-A1 (WO)
Title: Therapy for the treatment of cancer
Inventor: BJORKLUND CHAD
IPC: A61K31/573
Filed: 2020-12-01
Abstract: Provided herein are methods of treating and/or managing cancer, which comprise administering to a patient Compound A, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. Additionally, provided herein are methods of treating and/or managing cancer, which comprise administering to a patient Compound A, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, in combination with a second agent selected from the group consisting of an anti-CD20 antibody, an HDAC inhibitor, a proteasome inhibitor, an anti-CD38 antibody, an anti-SLAMF7 antibody, a nuclear export inhibitor, a BCL-2 inhibitor, and an immune checkpoint inhibitor. Also provided herein are combination therapies for treating and/or managing cancer, which further comprise dexamethasone as a third agent.
Patent WO-2022125065-A1 (WO)
Title: Attache de poutre en i
Inventor: MORGAN JUSTIN KANE
IPC: F16B2/06
Filed: 2020-12-08
Abstract: L'invention concerne une attache de poutre en I (10) qui a un premier élément de serrage (26) ayant une première surface de mise en prise de bride (28) conçue pour venir en prise avec une première surface de bride d'une bride d'une poutre en I. Le premier élément de serrage a une première surface de mise en prise d'âme (30) conçue pour venir en prise avec une première surface d'âme d'une âme de la poutre en I. Un deuxième élément de serrage (32) est prévu et conçu pour venir en prise avec la première surface de bride et une seconde surface d'âme de l'âme. Les premier et deuxième éléments de serrage sont conçus pour se déplacer l'un par rapport à l'autre dans une direction (28) perpendiculaire aux première et seconde surfaces d'âme. Un troisième élément de serrage (40) est présent et présente une troisième surface de mise en prise de bride (42) conçue pour venir en prise avec une seconde surface de bride de la bride. Le troisième élément de serrage est conçu pour se déplacer vers la seconde surface de bride de la bride de la poutre en I.
Patent WO-2021127081-A1 (WO)
Title: Method for preparing modified filler, compositions and articles containing same
Inventor: DOS SANTOS FREIRE LUCAS
IPC: C08L9/06
Filed: 2020-12-17
Abstract: Provided is a method for preparing a modified filler. The method includes in sequence providing an acidified aqueous slurry of an untreated inorganic filler which has not been previously dried; an emulsifier material; and a hydrophobating agent having the following structural formula (I): (I) Ra ̱ M-X(4-a) wherein: R is C6 to C22 alkyl, M is silicon, titanium or zirconium, X is OR' or halogen, R' is C1 to C4 alkyl, and a is 1; washing and/or filtering the acidified aqueous slurry to obtain a modified filler; and, optionally, drying the modified filler. Polymeric compositions and articles also are provided.
Patent WO-2021133960-A1 (WO)
Title: Icônes d'utilisateur expressives dans une interface de système de messagerie basée sur une carte
Inventor: GIOVANNINI DONALD
IPC: G06F3/0481
Filed: 2020-12-23
Abstract: L'invention concerne des systèmes, des dispositifs, des procédés et des instructions pour générer et utiliser des icônes expressives avec des indicateurs d'état pour une interface d'utilisateur graphique (GUI) basée sur une carte. Un mode de réalisation consiste à accéder à des informations d'emplacement, à des informations d'icône de données de carte et à des informations d'indicateur d'état associées à un compte d'une plateforme de médias sociaux. Un dispositif provoque ensuite la génération d'une icône expressive combinée générée à l'aide des informations d'icône et de l'indicateur d'état, et provoque l'affichage d'une interface de carte avec les données de carte et l'icône expressive combinée positionnée à un emplacement indiqué par les informations d'emplacement.
Patent WO-2021183210-A1 (WO)
Title: Polyaxial drill guide
Inventor: HALES RICHARD CLAY
IPC: A61B17/88
Filed: 2021-01-12
Abstract: An orthopedic drill guide assembly is disclosed. The assembly can include an elongated shaft having a proximal end and a distal end, and a first guide member that includes a bonecontacting surface and a second surface opposite the bone-contacting surface. The first guide member is provided at the distal end of the elongated shaft. The first guide member includes one or more guide holes that are configured for receiving a drill bit at an angle that can vary from 0 to 30 degrees from orthogonal of the bone-contacting surface.
Patent WO-2021146335-A1 (WO)
Title: Quantitative mapping of mri relaxation parameters
Inventor: QIN QIN
IPC: G16H30/40
Filed: 2021-01-13
Abstract: Magnetic resonance imaging according to the present invention includes T1, T2, or diffusion mapping with improved image resolution. The improved image resolution is achieved by leveraging the delay in the image acquisition to remove the partial volume effect of fluid in and around the tissue being imaged.
Patent WO-2022154795-A1 (WO)
Inventor: HUNG MING CHANG
IPC: G06F9/4401
Filed: 2021-01-15
Abstract: An electronic device may include a first non-volatile storage device having a first storage region, a second non-volatile storage device having a second storage region, and a processor. The processor may detect a modification to a data attribute, generate a first unified extensible firmware interface (UEFI) variable including modified data and previous data associated with the data attribute, and store the first UEFI variable in the first storage region via a first UEFI runtime service. Further, the processor may generate a second UEFI variable to include data indicating the modification to the data attribute and a counter to record boot count. Furthermore, the processor may store the second UEFI variable in the second storage region via the first UEFI runtime service. The processor selectively read, via a second UEFI runtime service, the modified data or previous data from the first storage region based on the second UEFI variable.
Patent WO-2021154608-A1 (WO)
Title: Communication apparatus configured to manage user identification queries and render user identification interfaces within a group-based communication system
Inventor: KLYM JASON
IPC: H04L29/08
Filed: 2021-01-22
Abstract: Various embodiments of the present invention are directed to a communications apparatus and associated methods configured for managing user identification queries. The communication apparatus is configured to receive a user identification query comprising a requesting user identifier and a target user identifier, compare the target user identifier to a user status cache associated with the requesting user identifier to determine a known status, an unknown status, or a pending status, and cause rendering of a known user identification interface or a limited user identification interface. In some embodiments, the communication apparatus is configured to transmit a client device hold instruction in response to determining the pending status for the target user identifier with respective to a given requesting user identifier. Various embodiments discussed herein mediate and resolve voluminous user identification queries through a specially configured group-based caching service and associated system architecture.
Patent WO-2021155131-A1 (WO)
Title: Device based lock via electrical socket
Inventor: AVGANIM MEIR
IPC: H01R13/639
Filed: 2021-01-29
Abstract: An electronically lockable, electrical plug configured to communicate power and data signals to mobile electronic devices (MED) includes a male electrical plug body insertable into a female electrical socket of the MED and plurality of electrical contacts defined in the male electrical plug for communicating the power and data signals to and from the MED, via corresponding electrical contacts associated with an MED electrical socket. The MED electrical socket is shaped and sized to physically receive and support therein said male electrical plug body. Plug locking elements are formed in the male plug body are so formed as to be lockable to or with corresponding, complementary socket locking elements of the MED, so that upon insertion of the male plug body into the MED socket the electrical plug is locked with the MED. An associated, electronically operable locking mechanism is operable to mechanically disengage the plug locking elements from the socket locking elements to thereby enable the electrical plug to be released from the MED and an electrical cable is coupled to the male plug body for electrically conducting the signals.
Patent WO-2021155304-A1 (WO)
Title: Mode multiplexer/demultiplexer using metamaterials for optical fiber communications
Inventor: CAPASSO FEDERICO
IPC: G02B6/122
Filed: 2021-01-29
Abstract: Systems, devices, and techniques for performing wavelength division multiplexing or demultiplexing using one or more metamaterials in an optical communications systems are described. An optical device may be configured to shift one or more phase profiles of an optical signal using one or more stages of metamaterials to multiplex or demultiplex wavelengths of optical signals. The optical device may be an example of a stacked design with two or more stages of metamaterials stacked on top of one another. The optical device may be an example of a folded design that reflects optical signals between different stages of metamaterials.
Patent WO-2021216176-A1 (WO)
Inventor: TABORGA CLAURE MICAELA
IPC: B01J37/18
Filed: 2021-02-19
Abstract: A catalyst for converting C9+ aromatics to lighter aromatics includes a metallic function derived from a metal such as platinum constrained within cages and/or channels of a microporous material, such as chabazite, wherein the cages and/or channels of the microporous material are defined by 8 tetrahedral atoms or fewer; and an acidic function derived from an additional zeolite having cages and/or channels defined by 10 or more tetrahedral atoms, wherein the microporous material providing the metallic function and additional zeolite providing the acidic function are coupled by a binder.
Patent WO-2021173673-A1 (WO)
Title: Émerillon filaire dans un forage de puits de forage
Inventor: LOONI QADIR
IPC: E21B17/05
Filed: 2021-02-24
Abstract: La présente invention concerne un émerillon qui comprend un segment mâle, un segment femelle et une broche de verrouillage. Le segment mâle peut s'accoupler avec le segment femelle et la broche de verrouillage peut passer à travers le segment femelle et venir en prise avec le segment mâle pour empêcher un mouvement axial relatif du segment mâle et du segment femelle tout en permettant un mouvement de rotation relatif du segment mâle et du segment femelle. Le segment mâle comprend une première bague conductrice configurée pour être couplée à un premier fil. Le segment femelle comprend une seconde bague conductrice configurée pour être couplée à un second fil. Le contact entre les première et seconde bagues conductrices établit une connexion électrique entre les premier et second fils.
Patent WO-2021178780-A1 (WO)
Title: Indazoles et azaindazoles en tant qu'inhibiteurs de lrrk2
Inventor: GAROFALO ALBERT W
IPC: C07D401/12
Filed: 2021-03-05
Abstract: La présente invention concerne des composés indazole et azaindazole qui sont des inhibiteurs de LRRK2 et sont utiles dans le traitement de troubles du SNC.
Patent WO-2021178947-A1 (WO)
Inventor: ZHENG SHUNFENG
IPC: E21B47/12
Filed: 2021-03-08
Abstract: Apparatus and methods for automating well construction operations based on detected abnormal events. A method may comprise commencing operation of an equipment controller of a control system for monitoring and controlling a well construction system. The well construction system may comprise well construction equipment operable to perform well construction operations. Commencing operation of the equipment controller may cause the equipment controller to receive sensor data from a sensor, detect an abnormal downhole event based on the sensor data, select an operational sequence to be performed by the well construction equipment based on the abnormal downhole event, and output control data to cause the well construction equipment to perform the operational sequence thereby mitigating the abnormal downhole event.
Patent WO-2021188683-A1 (WO)
Title: Load-assisting glove
Inventor: KISHINEFF MARK
IPC: F16M13/04
Filed: 2021-03-17
Abstract: A load-assisting glove is an apparatus that assists users with the load from a handheld tool such as a shovel. The apparatus may include a work glove and a bracing socket. The work glove maintains the bracing socket at an ergonomic position adjacent to the user's arm. The bracing socket lessens the amount of grip needed to work with the handheld tool. The work glove includes a wrist opening, a palmar portion, and a dorsal portion. The wrist opening enables the user to put on the work glove. The palmar portion protects the palmar area of the hand, while the dorsal portion protects the dorsal area. The bracing socket includes an open socket end and a closed socket end. The open socket end enables the end of the tool handle to be inserted into the bracing socket, while the closed socket end keeps the handle end within the bracing socket.
Patent WO-2021188889-A1 (WO)
Inventor: DHINGRA DALIA
IPC: C12Q1/6806
Filed: 2021-03-19
Abstract: Est divulgué ici un flux de travail d'analyse monocellulaire impliquant une amplification du génome entier pour développer des banques d'ADN de génome entier monocellulaire. Le flux de travail d'analyse monocellulaire Implique l'encapsulation et la lyse de cellules dans des gouttelettes individuelles et la libération d'ADN génomique à partir de la chromatine à l'intérieur de la gouttelette. Les transposases accèdent à l'ADN génomique libéré et à des séquences d'adaptateur d'Insertion dans les fragments d'acide nucléique clivé, générant ainsi des fragments d'ADN génomique marqués couvrant l'ensemble du génome. L'ADN génomique marqué subit une amplification et un séquençage d'acide nucléique pour générer des banques d'ADN de génome entier monocellulaire.
Patent WO-2021202269-A1 (WO)
Title: Dense modified silica with silane compounds and methods of making and using same
Inventor: WANG HELI
IPC: C08J3/20
Filed: 2021-03-26
Abstract: A modified silica comprising a virgin silica and a silane coupling agent wherein the silane coupling agent is present in an amount of equal to or greater than about 10 weight percent (wt.%) based on the total weight of the modified silica. The virgin silica has a particle size of from about 1 nm to about 400 nm. The silane coupling agent comprises a silane having a general formula Si(OR 1 ) 3 (CH 2 ) n OOCR 2 , wherein R 1  is an alkyl, n is an integer from about 2 to about 9, and R 2  is a coupling moiety. R 2  is an olefin, a hydroxyl group, or an alkyl with a chain having from 1 to about 20 carbon atoms. The polymer comprises a hydrophilic polymer, a hydrophobic polymer, or combinations thereof. A silica-polymer composite (SPC) comprising the modified silica and a polymer. An SPC-modified polymer comprising the SPC and an additional polymer.
Patent WO-2021207598-A1 (WO)
Title: Combination treatment with an agonist of p53 and a second therapeutic agent
Inventor: ATTAR EYAL
IPC: A61K39/395
Filed: 2021-04-09
Abstract: Provided herein are methods of treating a disease or disorder in a subject using a combination therapy of a p53 agonist such as a p53 reactivator and a second therapeutic agent such as an inhibitor of PD-1 mediated signaling, a Bruton's tyrosine kinase (BTK) inhibitor, an exportin 1 (XPO1) inhibitor, or an inhibitor of Wee1-like protein kinase (WEE1).
Patent WO-2021207606-A1 (WO)
Title: Methods for treatment of coronavirus infections
Inventor: TRIPP RALPH A
IPC: A61K31/195
Filed: 2021-04-09
Abstract: Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can be therapeutic and/or prophylactic. The amount of probenecid, metabolite or analog thereof, or pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a  Severe acute respiratory syndrome-related coronavirus  such as   SARS-CoV-2 or SARS-CoV, a  Middle East respiratory syndrome-related coronavirus  such as MERS-CoV, or a coronavirus that causes the common cold.
Patent WO-2022250681-A1 (WO)
Inventor: RAKULJIC GEORGE
IPC: G02B6/122
Filed: 2021-05-28
Abstract: A photonic integrated circuit is provided having a plurality of light paths each configured to branch light received from at least one light receiving input to a first light path section and a second light path section, to turn the polarization of at least a portion of the light received at the receiving input into light of a first linear polarization and light of a second linear polarization that is orthogonal to the first polarization; wherein the first light path section is configured to emit light of the first linear polarization to the outside; wherein the second light path section is configured to determine an interference signal using the light having the second linear polarization of the first light path and light having the second received from the outside.
Patent WO-2021248068-A1 (WO)
Inventor: PENG DAIYI
IPC: G06N5/00
Filed: 2021-06-04
Abstract: A method for searching for an output machine learning (ML) algorithm to perform an ML task is described. The method comprising: receiving data specifying an input ML algorithm; receiving data specifying a search algorithm that searches for candidate ML algorithms and an evaluation function that evaluates the performance of candidate ML algorithms; generating data representing a symbolic tree from the input ML algorithm; generating data representing a hyper symbolic tree from the symbolic tree; searching an algorithm search space that defines a set of possible concrete symbolic trees from the hyper symbolic tree for candidate ML algorithms and training the candidate ML algorithms to determine a respective performance metric for each candidate ML algorithm; and selecting one or more trained candidate ML algorithms among the trained candidate ML algorithms based on the determined performance metrics.
Patent WO-2021252683-A1 (WO)
Title: Systems and methods for controlling automated systems using integer programming and column generation techniques
Inventor: HAGHANI NAVEED
IPC: G06Q10/00
Filed: 2021-06-09
Abstract: Systems and methods for controlling automated systems, such as robots and other devices/resources, using integer programming and column generation techniques, are provided. The system retrieves location and movement data corresponding to at least one automated system, and processes the location and movement data using an integer linear programming algorithm. The system also optimizes the integer linear programming algorithm using a column generation algorithm, and solves a pricing problem associated with generating routes for the at least one automated system. Then, the system generates a route based on outputs of the integer linear programming algorithm, the column generation algorithm, and solving of the pricing problem, and transmits the route to the at least one automated system, the at least one automated system executing the route to control a location or a movement of the at least one automated system.
Patent WO-2021263171-A1 (WO)
Inventor: KOZIKOWSKI ALAN
IPC: A61K39/00
Filed: 2021-06-25
Abstract: The present disclosure provides methods, pharmaceutical compositions, and kits comprising histone deacetylase (HD AC) inhibitors of formula I, or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , L 1 , L 2 , m, n, p, X, Y, and Z are as defined in the specification, including methods of increasing the sensitivity of cancer cells to the cytotoxic effects of radiotherapy and/or chemotherapy in a subject.
Patent WO-2022026104-A1 (WO)
Inventor: SCHULER FRANCESCA
IPC: H04W4/06
Filed: 2021-06-29
Abstract: Systems and methods for transmitting near real-time geographic mass messaging requests. One example method (300) includes receiving a geographic mass messaging request via a transceiver (230), the geographic mass messaging request including a message, a geographic reference, and a requesting agency identifier, and having at least one request characteristic. The method (300) includes assigning, with an electronic processor (210), a priority to the geographic mass messaging request based on an electronically stored alerting authority (102) policy (405) and at least one selected from the group consisting of the requesting agency identifier, the geographic reference, and the at least one request characteristic. The method (300) includes, responsive to determining that the priority does not meet a priority threshold, transmitting one of a request denied message and a request modification proposal via the transceiver (230) to the requesting agency.
Patent WO-2022066259-A1 (WO)
Title: Modèle auxiliaire de prédiction de nouveaux paramètres de modèle
Inventor: ZHANG CHENG
IPC: G06N3/04
Filed: 2021-06-30
Abstract: Procédé mis en œuvre par ordinateur d'apprentissage d'un modèle d'apprentissage machine auxiliaire permettant de prédire un ensemble de nouveaux paramètres d'un modèle d'apprentissage machine principal, le modèle principal étant configuré pour se transformer à partir d'un sous-ensemble observé d'un ensemble de caractéristiques du monde réel en une version prédite de l'ensemble de caractéristiques du monde réel.
Patent WO-2022020396-A1 (WO)
Title: Vacuum health detection for imaging systems and methods
Inventor: SIMOLON BRIAN B
IPC: H04N5/33
Filed: 2021-07-20
Abstract: Techniques for facilitating vacuum health detection for imaging systems and methods are provided. In one example, an imaging device includes a detector configured to generate a first reference signal. The imaging device further includes a buffer circuit configured to store a value of the first reference signal. The imaging device further includes a processing circuit coupled to the buffer circuit. The processing circuit is configured to determine a first predetermined value based on a first temperature associated with the detector. The processing circuit is further configured to determine vacuum integrity associated with the detector based at least on the value of the first reference signal and the first predetermined value. Related methods and systems are also provided.
Patent WO-2022035599-A1 (WO)
Inventor: VAN ROSSUM GIJSBERTUS JOHANNES
IPC: C11B3/12
Filed: 2021-07-28
Abstract: Present invention relates to a process for reducing the MOSH and/or MOAH content from vegetable oil selected from the group consisting of palm-based oil, cocoa butter-based oil and any mixtures thereof, and comprising steps of: a) subjecting the vegetable oil to a short-path evaporation, wherein the short-path evaporation is performed at a pressure of below 1 mbar, at an evaporation temperature in a range of from 235 and 290°C, and with a feed rate per unit area of evaporator surface of the shorth-path evaporation equipment in a range of from 35 to 102 kg/h.m 2 , and thus obtaining a retentate vegetable oil and a distillate, b) Contacting the retentate vegetable oil with an adsorbent, and c) Subjecting the bleached retentate vegetable oil to a further refining step.