Patent SG-11201804899Y-A (SG)
Title: Indane derivatives as mglur7 modulators
Inventor: GOLDBY ANNE
IPC: C07D309/08
Filed: 2017-01-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization MD 1111101110101011111 HO 1111101110111011 OH MOH 1111110 IIE III International Bureau .. ..... ..Yi j (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/131221 Al 3 August 2017 (03.08.2017) W I P0 I P CT (51) International Patent Classification: WHITE, Katy; c/o Takeda Cambridge Limited, 418 Cam- C07C 233/23 (2006.01) C07C 317/30 (2006.01) bridge Science Park, Milton Road, Cambridge CB4 OPA C07D 309/08 (2006.01) CO7D 239/42 (2006.01) (GB). CO7D 309/14 (2006.01) CO7D 413/12 (2006.01) C07C 271/24 (2006.01) CO7C 233/41 (2006.01) (74) Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo- CO7D 231/12 (2006.01) CO7D 261/10 (2006.01) hi., Osaka-shi, Osaka, 5410044 (JP). CO7D 231/14 (2006.01) CO7C 235/36 (2006.01) CO7C 311/06 (2006.01) CO7D 205/04 (2006.01) (81) Designated States (unless otherwise indicated, for every CO7D 237/14 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/JP2017/003078 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 24 January 2017 (24.01.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (25) Filing Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (30) Priority Data: ZA, ZM, ZW. 1601301.3 25 January 2016 (25.01.2016) GB (84) Designated States (unless otherwise indicated, for every (71) Applicant: TAKEDA PHARMACEUTICAL COM- kind of regional protection available): ARIPO (BW, GH, PANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Chuo-ku, Osaka-shi, Osaka, 5410045 (JP). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: GOLDBY, Anne; c/o Takeda Cambridge Lim- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, ited, 418 Cambridge Science Park, Milton Road, Cam- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, = bridge CB4 OPA (GB). LIWICKI, Gemma; c/o Takeda LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Cambridge Limited, 418 Cambridge Science Park, Milton SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = Road, Cambridge CB4 OPA (GB). MACK, Stephen; c/o GW, KM, ML, MR, NE, SN, TD, TG). = Takeda Cambridge Limited, 418 Cambridge Science Park, Published: = Milton Road, Cambridge CB4 OPA (GB). TEALL, Mar- - with tin; c/o Takeda Cambridge Limited, 418 Cambridge Sci- international search report (Art. 21(3)) = ence Park, Milton Road, Cambridge CB4 OPA (GB). = (54) Title: INDANE DERIVATIVES AS MGLUR7 MODULATORS R 2 = = = = Rt 1101 R 3 = R4' — N Il R4a .4 11 N N illa Il en (I) Il IN 1-1 (57) : The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, 0 R2, R3, R4a and R4 b are as defined in the specification, processes for their preparation, pharmaceutical compositions containing \" them and their use in therapy. The compounds of formula (I) are mGluR7 modulators.