baber/WOPTO huggingface dataset:
Patent CR-20180460-A (CR)
Title: Tratamiento contra el cáncer de útero
Inventor: FRITSCHE JENS;
IPC: G01N33/574
Filed: 2017-03-02
Abstract: La presente invención se refiere a péptidos, proteínas, ácidos nucleicos y células destinados a la utilización en métodos inmunoterapéuticos. En particular, la presente invención se refiere a la inmunoterapia contra el cáncer. La presente invención se refiere asimismo a epítopos peptídicos para linfocitos T asociados a tumores, solos o en combinación con otros péptidos asociados a tumores que, por ejemplo, pueden servir como principios activos farmacéuticos en composiciones vacunales destinadas a estimular respuestas inmunitarias antitumorales, o a estimular ex vivo linfocitos T que después serán transferidos a los pacientes. Los péptidos unidos a moléculas del complejo mayor de histocompatibilidad (MHC), o los péptidos como tales, también pueden ser dianas de anticuerpos, de receptores de linfocitos T solubles, y de otras moléculas de unión.
Patent CR-20220621-A (CR)
Title: Ring closing synthesis of macrocyclic mcl-1 inhibitor intermediates
Inventor: ROOSEN PHILIPP C
IPC: C07D513/08
Filed: 2021-05-05
Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.
Patent EC-SP003409-A (EC)
Title: Procedimiento para unir partes metalicas con materiales plasticos
Inventor: RIGOSI GIAN LUIGI
IPC: B05D7/14
Filed: 2000-03-31
Abstract: La presente invención se relaciona con un procedimiento para efectuar un acoplamiento entre un material plástico y una superficie de metal, que comprende los pasos de aplicar un polvo de una composición de polímero adhesivo a la superficie de metal: luego sobremoldear la superficie de metal con un material plástico, a través de moldeo por inyección; y finalmente aplicar calor a la superficie de metal.
Patent EC-SP003631-A (EC)
Title: Nueva forma cristalina de la sal disodica del acido n-[4-[2-amino-4,7 - dihidro-4-oxo-3h-pirrolo [2,3-d]-pirimidin-5-il)etil] benzoil]-l-glutamico y procedimientos para el mismo
Inventor: CHELIUS ERIK CHRISTOPHER
IPC: C07D487/02
Filed: 2000-08-23
Abstract: La presente inevnción se refiere al campo de la quimica farmacéutica y orgánica y proporciona una nueva forma cristalina antifolato disódico de la sal del ácido n- n-[4-[2-amino-4,7-dihidro-4-oxo-3H-pirrolo[2,3-d]-pirimidin-5-il)etil]benzoil]-L-glutámico de ahora en adelante MTA) utilizado para múltiples propósitos y procedimientos para el mismo.
Patent EC-SP045478-A (EC)
Title: Combinación farmacéutica en una nueva forma farmaceutica útil en la hipertensión arterial y en la insuficiencia coronaria estable.
Inventor: VISCONDE OMILTON JR
IPC: A61P9/10
Filed: 2004-12-08
Abstract: La presente invención propone la asociación farmacéutica estable entre un betabloqueador en la forma de granulado y un antagonista de los canales de calcio que pertenece a la clase de los dihidropiridínicos en la forma de comprimido, los cuales son revestidos por una cápsula de gelatina dura.
Patent EC-SP088078-A (EC)
Title: Derivados de un 1-feniltriazol
Inventor: VON DEYN WOLFGANG
IPC: A01N43/653
Filed: 2008-01-02
Abstract: Compuestos de la fórmula (I) dondeX 	es cloro o bromo;Y	es cloro o trifluorometilo; yA y B significan hidrógeno o metilo, siendo preciso, que uno de los radicales A o B signifique metilo;uso de los compuestos de la fórmula I para combatir insectos o acáridos y para tratar, controlar, prevenir o proteger animales contra la infestación o infección por parásitos, y composiciones que comprenden compuestos de la fórmula I.
Patent EC-SP941140-A (EC)
Inventor: MONAGHAN SANDRA MARINA
IPC: C07F7/18
Filed: 1994-08-04
Abstract: A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein X, O R, R1, R2, R3, and R4 are defined in the specification; compositions containing such compounds; intermediates used in the preparation of such compounds; and methods for treating a disease associated with the altered tone and/or motility of smooth muscle, for example chronic obstructive airways disease, asthma, urinary incontinence, irritable bowel syndrome, diverticular disease, oesophageal achalasia, and hypertension.
Patent EC-SP951440-A (EC)
Title: Compuestos utiles para tratar infecciones por retrovirus
Inventor: ROMINES KAREN RENE
IPC: C07D309/20
Filed: 1995-05-05
Abstract: Se relaciona con compuestos de la fórmula I y II que son piran-2-onas, 5,6-dihidro-piran-2-onas, 4 hidroxi-benzopiran-2-onas, 4-hidroxi-cicloalquil [b] piran-2-onas, y derivados de los mismos, los cuales son útiles como inhibidores de un retrovirus en una célula de mamífero que esté infectado con dicho retrovirus donde R10 y R20 en conjunto son.
Patent EC-SP992960-A (EC)
Title: Un metodo y un sistema para expandir la capacidad de datos de un canal de control de red celular
Inventor: SANDIDGE JERE T
Filed: 1999-05-21
Abstract: Se trata de expandir la capacidad de transmisión de datos de un canal de control de avance de un sistema de radiotelefonía celular móvil (CMR), al utilizar campos de datos que permanecerían inutilizados en un sistema de mensaje de datos convencional, es posible enviar un identificador de operación a un dispositivo de reporte de datos. El canal de control de avance transmite mensajes de control que pueden hacer que los dispositivos celulares realicen ciertas funciones de comunicación. Un cvampo de datos del código de orden dentro del mensaje de control define la funcionalidad del mensaje. Al utilizar el campo de datos del código de orden para recurrir a la funcionalidad del mensaje en espera del mensaje de control, y al reemplazar los datos de mensaje en espera con un identificador de operación, aumenta la capacidad de transmisión de datos del canal de control de avance. Es posible hacer que un dispositivo de reporte de datos realice una operación definida por el identificador de operación. El identificador de operación piuede definir una operación especificada en una lista de operaciones disponibles. En el caso de
Patent FI-20012144-A (FI)
Inventor: ISOLA ANTTI SAKARI HERMAN
IPC: D21C7/14
Filed: 2001-11-06
Abstract: The present invention relates to an arrangement for mounting a screen (20) in a continuous reactor used for making chemical pulp or paper pulp. Such a reactor comprises a substantially cylindrical vessel arranged in an upright position, the vessel having a smaller diameter at the top end of the reactor than at the bottom end of the reactor, the diameter of the reactor being changed at regionally defined areas by means of one or more conical sections (4). Said screens are mounted at these conical sections to remove liquid from chips or pulp in the reactor. In the present arrangement an upper edge (21) of the screen (20), which, in the operating position, is located higher, is arranged in the region of the conical section (4). In particular, the screen extends substantially to the section of the conical section, which has the smallest diameter.
Patent GB-1050154-A (GB)
IPC: G10D3/14
Abstract: 1,050,154. Stringed musical instruments. ORMSTON BURNS Ltd. Dec. 5, 1962 [Dec. 6. 1961], No. 43736/61. Heading G5J. A bridge of a stringed musical instrument is mounted on rollers or on ball races so that it moves freely in the longitudinal direction of the strings as tension varies. In a guitar, the bridgeassembly 309 comprises an individual bridge 310 to 315 for each string and is combined with a tremolo device. A framework comprising side members 329, 330 is secured to the body of the instrument and carries four ball races on which the bridge assembly runs. Only two of the races 335, 336 are shown in Fig. 4. The strings run from the bridges under a rod 321 and are anchored to a spindle 308 which is turned by handle 353 to control the tension. Springs:346, 347 attached to a bar 348 normally balance the torque exerted on the spindle 308 by the strings. An adjustment screw 349 links the bar 348 to a crosspiece 331 on the framework. Each individual bridge can be adjusted in the direction of the strings by a screw 327 and perpendicular to the strings by screws 328.
Patent GB-1052700-A (GB)
IPC: C08F12/32
Abstract: 1,052,700. Lubricants. SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ N.V. Dec. 7, 1964 [Dec. 9, 1963], No. 49748/64. Heading C5F. [Also in Division C3] A lubricant comprises a major proportion of a lubricating oil and a minor proportion of a copolymer of ethylene and stilbene obtained using an organic lithium catalyst. Specified oils are transformer, turbine, mineral and industrial oils and hydraulic fluids, e.g. paraffinic, naphthenic or asphaltic base oils having a viscosity of from SAE 5W to SAE 140. The composition may include phenols, amines, sulphides, phospho-sulphurized terpenes, esters of phosphorus acids and their thio-derivatives.
Patent GB-1052730-A (GB)
IPC: F04B43/12
Abstract: 1,052,730. Rotary pumps. CREED & CO. Ltd. Oct.22, 1965 [Oct. 24, 1964], No.44755/65. Heading F1F. To lengthen the life of the hose of a flexiblehose pump comprising a rotatable carrier 10, Fig. 2, (not shown) carrying a plurality of rollers 11, which on rotation of the carrier by means of a pinion 13, deforms the hose, a layer 3 of resilient abrasive - resistant material is arranged between the rollers and a non-circular hose 1 having a flattened surface adjacent the layer 3 to minimise cracking of the hose walls. Preferably an insert 2 of kidney-shape crosssection extends inside the hose over an arc of about 120 degrees with its concave surface uppermost.
Patent GB-1084226-A (GB)
IPC: F27D11/02
Abstract: 1,084,226. Automatic temperature control systems. PERMAGLASS Inc. Sept. 23, 1964 [Feb. 17, 1964], No. 38808/64. Heading G3R. To equalize the temperature in different parts of an electric furnace, it is divided into a plurality of zones one of which is selected as a master, normally the one having the greatest heat load, the temperature of which is sensed and compared with the temperature of the other zones, the difference controlling the energy supplied to each zone in a determined relationship. Zone 2 is selected as a master having one thermocouple 125 controlling the heating elements in that zone through contactors 120, and a master thermocouple 126 in series opposition to each of the thermocouples 126 in the other zones 1 and 3-6 which switch off the heating elements in these zones when the thermocouple outputs are higher, or outside a determined relationship. The arrangement is described with reference to a sheet glass tempering furnace.
Patent GB-1095306-A (GB)
IPC: A46B15/00
Abstract: 1,095,306. Brushes. CAMPBELL BRUSHES Ltd. Sept. 28, 1966 [Oct. 26, 1965], No. 45174/65. Heading A4K. In a method of making a paint brush, in which the butt ends of the bristles are set in liquid heat-curable resin in a ferrule, the brush handle 2 is first joined to the empty ferrule 1, in any known way, to form a receptacle for the resin. The receptacle may be completely filled with resin or it may initially be lined with a plastic mass of pitch and saw dust, pressed out into a layer 4 having a flat or ridged top, and the resin 6 then poured in. The bristles (7), in a funnel (8), are helped by vibration to penetrate the resin 6 and rest on the top of layer 4. The funnel is removed by lateral separation into two halves (8<SP>1</SP>, Fig. 5, not shown) and the resin 6 finally cured.
Patent GB-1143538-A (GB)
IPC: E21B47/00
Abstract: 1,143,538. Dynamometers. F.LEUTERT. Feb.23, 1966 [March 20, 1965], No.7915/66. Heading G1W. A recording device is connected to but is remote from a dynamometer adapted for temporary attachment to a pump rod 1 to take the load between the rod 1 and the pump cross-head in order to sense cyclic variations in load and to transmit corresponding variations to the recording device. As shown, the load is sensed by a hydraulic dynamometer which in one embodiment, Fig. 3, uses a potentiometer 4 to produce a corresponding electrical variable for transmission by an electric cable 6 to an electrical recording device 5. In the embodiment, Fig.4 (not shown) pressure is transmitted hydraulically from the dynamometer to a fluid-pressure recording device (9) and in a final embodiment, Fig. 5 (not shown) a pressure transducer in the form of a wire strain gauge transducer serves to transmit electronic signals to the recorder (12). The record sheets may be driven continuously in accordance with time or distance travelled and limit switches may be used to superimpose distance or time marks respectively, preferably in dead-centre positions.
Patent GB-1230112-A (GB)
IPC: B60Q1/42
Filed: 1968-08-12
Abstract: 1,230,112. Inert switches; retractive switches. ESSEX INTERNATIONAL Inc. 12 Aug., 1968, No. 38362/68. Heading H1N. Pivotal movement of member 40 in a horizontal plane about pivots 37, 10 actuates a direction signalling switch; rotational movement of member 40 about its longitudinal axis actuates a switch controlling windscreen wipers; and depression of member 40 actuates a windscreen washer switch. The direction signalling switch comprises an arcuate member 13 mounted on the square section end 12 of pivot member 10 for rotation between a pair of stops 21. Bridging contacts 17, 18 movable with member 13 close signalling circuits in the extreme positions. Flexible arms 15 of the arcuate member 13 are deflected by a cam 4 carried by steering shaft 1 without the body 14 of member 13 rotating, when the shaft is moved from its central position, but when the shaft is returned to its central position the arm 15 is deflected into engagement with a rigid projection 16 of member 13 so that member 13 is rotated to its central position. Stops 16<SP>1</SP>, carried by arms 16, co-operate with detent surfaces 8<SP>1</SP> to hold member 13 in one of its three positions. Member 40 is slidably and rotatably mounted in a pivoted frame 25 which carries a nylon housing 50. Rotatable with member 40 is a spring biased rotor 74 which carries a self-aligning contact bridge 78, 79, 80 which co-operates with arcuately spaced fixed contacts to control the windscreen wipers. Rotatable with rotor 74 is an operating member 86, this member being rotated by the member 40 and being keyed to rotor 74 by a key 96. Projections 88 of member 86 cooperate with recesses 89 in a snap-fitting cover 81 to locate bridging contact 78, 79, 80 in one of its three angular operating positions. Depression of member 40 causes member 86 to slide inwardly so that a projection 88a thereon engages a spring contact blade 71 and forces it into engagement with a fixed contact to close the windscreen washer circuit. The arrangement of the blade 71 in relation to projection 88a may be such that the blade is only closed on depression of member 86 if member 86 has first been rotated to a given angular position.
Patent GB-1231272-A (GB)
IPC: C07C1/00
Filed: 1968-04-02
Abstract: 1,231,272. Olefin catalysts. PHILLIPS PETROLEUM CO. 2 April, 1968 [3 April, 1967 (2) 26 Oct., 1967], No. 15847/68. Heading B1E. [Also in Division C5] The olefine reaction is carried out in the presence of a disproportionation catalyst comprising silica or thoria promoted by an oxide or sulphide of molybdenum or tungsten or an oxide of rhenium or tellurium OR alumina promoted by an oxide or sulphide or hexacarbonyl of molybdenum or tungsten or rhenium oxide or an alkali or alkaline earth metal, ammonium or bismuth phosphomolybdate OR aluminium, calcium, zirconium, magnesium or titanium phosphate promoted by an oxide or sulphide or hexacarbonyl of molybdenum or tungsten or rhenium oxide or magnesium tungstate or beryllium phospho tungstate OR silica promoted by molybdenum or tungsten hexacarbonyl and an isomerisation catalyst comprising magnesium oxide, phosphoric acid, bauxite or cobalt, iron or manganese oxides on alumina.
Patent GB-1232489-A (GB)
IPC: F16B7/02
Filed: 1968-11-02
Abstract: 1,232,489. Tube connectors. R. A. G. SMITH. 3 Nov., 1969 [2 Nov., 1968], No. 52055/68. Heading F2G. [Also in Division A4] A tube connector 1 comprises a cylindrical skirt portion 2 to fit within the end of a first tube A, a head portion 3 with an end face receiving a second tube B perpendicular to the first tube, the skirt being longitudinally slit and internally profiled to taper away from its free end and to locate non rotatably a hexagonal nut 5, and a screw 8 passing through holes 7 in the tube B and a central hole 4 in the end face to screw into the nut, thereby expanding the skirt portion while simultaneously tightening the second tube B on to the end face. Preferably the skirt portion is slit at every other vertex.
Patent GB-1232687-A (GB)
IPC: B63B1/12
Filed: 1968-07-12
Abstract: 1,232,687. Ships. LITTON INDUSTRIES Inc. 12 July, 1968 [14 July, 1967], No. 33444/68. Heading B7A. A marine vessel comprises two buoyant underwater hull portions 18 connected by two buoyant intermediate hull portions 14 to an above water hull portion 10. The underwater portions 18 are of elliptical cross-section with tapered ends and carry propellers (26) and rudders (24). Portions 14 have concave side walls of parabolic cross-section. The underwater portions may be of hydrofoil longitudinal cross-section.
Patent GB-1233798-A (GB)
IPC: C07C309/41
Filed: 1968-10-29
Abstract: 1,233,798. Lithium hydroquinone sulphonate. LABORATOIRES OM S.A. 29 Oct., 1968 [9 Nov., 1967 (2)], No. 51323/68. Heading C2C. Novel lithium hydroquinone sulphonate is prepared (a) by reaction of p-benzoquinone and lithium bisulphite in a solvent; or (b) by reaction of potassium hydroquinone sulphonate with a lithium salt of an organic or inorganic acid, e.g. lithium perchlorate or bitartrate, in a solvent in which the desired product is solublebut in which the potassium salt formed as a by product is not soluble or only slightly soluble. Pharmaceutical compositions having antihemorrhagic activity comprise, as active ingredient, lithium hydroquinone sulphonate, together with a pharmaceutically acceptable carrier, and may be administered orally, rectally or parenterally.
Patent GB-1237964-A (GB)
IPC: H01M12/08
Filed: 1969-07-25
Abstract: 1,237,964. Secondary zinc-halogen cells. CONSIGLIO NAZIONALE DELLE RICERCHE. 25 July, 1969 [23 April, 1969], No. 37595/69. Heading H1B. A zinc-halogen secondary cell has an aqueous electrolyte and a cathode comprising a conductor partly contacting the electrolyte and partly contacting a mixture of an alkylammonium perchlorate and an inert conductive powder. The preferred salts are NMe 4 ClO 4  and NBu 4 ClO 4 . As shown in Fig. 5 a plurality of rod cathodes 20 are in contact with electrolyte flowing through the cell and with a mixture 14 of NMe 4 ClO 4  and a conductive powder, e.g. graphite, supported in insulating cradles 17. The cathode rods 20 are connected in parallel by side walls of conductive material with an insulating coating on their inside surfaces whilst zinc anodes 3 are also connected in parallel. A number of cells can be connected in series with electrolyte being circulated from a storage tank (Figs. 7, 8, not shown). In other embodiments the cathode mixture is supported in grooves in the surface of the cathode conductor.
Patent GB-1238538-A (GB)
IPC: H02M5/257
Filed: 1968-10-02
Abstract: 1,238,538. Automatic voltage stabilizers. ELECTRONIC CONTROL CORP. Oct.2, 1968 [Oct.4, 1967], No.46693/68. Heading G3X. A gated semi-conductor switch which supplies power to a load from an A.C . supply, is provided with a firing circuit to automatically vary the firing angle of the switch with variations of the supply voltage about a normal value and so maintain constant load power. Fig.4 shows the firing circuit which is similar to a known circuit, Fig.3 (not shown) but replaces the capacitor (C1) of that circuit by a conventional trigger diode Z N  which provides the automatic variation of firing angle in a manner dependent on its V/I characteristic and the alteration thereof produced by supply voltage variation. Basically this variation alters the slope of the negative resistance portion of the characteristic following breakdown, so that an increased supply voltage increases the slope and vice versa, Fig.5 (not shown). Thus the increased supply voltage delays charging of the capacitor C2 and firing of the semi-conductor switch, whilst decreased supply voltage retards these functions, it being stated that the action of the non- compensating positive resistance portion of the characteristic is outweighed by the action of the compensating negative resistance portion. A discussion is given of the compensating effect of the diode Z N  in relation to the circuit components C2, D1, for variations of supply voltage above and below the normal value. Fig.7 shows the application of the invention to a dimmer circuit for a lamp load L controlled by a bidirectional semi-conductor switch Q1, whose firing angle is set to a predetermined value by a potentiometer R5 and is automatically varied about this value by the compensating action of the firing circuit R3, R4, C2, D1, Z N . The arrangement is such that maximum compensation for supply voltage variation occurs at a setting of the potentiometer R5 corresponding to a low intensity of the lamp L.
Patent GB-1250649-A (GB)
IPC: B06B1/18
Filed: 1968-12-17
Abstract: 1,250,649. Article gripping. INTERNATIONAL BUSINESS MACHINES CORP. 17 Dec., 1968 [2 Jan., 1968], No. 59926/68. Heading B8H. [Also in Division F1] An article handling device comprises a gripper unit 45 which is simultaneously oscillatable longitudinally and transversely to facilitate coincidence of the article and a part to be engaged thereby. The gripper unit 45 comprises two jaws 406 mounted on parallel links 414 which are pivotable about pins 411 to grip an article when the remote ends of two of the links are opened against spring bias by a fluid pressure operated wedge cam 409. The unit 45 is detachably mounted on a shaft 412 including a detent device 413 which is locked in the attached position by pressure fluid supplied to the jaw operating cam 409. The shaft 412 is mounted in a manipulator 38 which is driven by a digital drive, and incorporates a pulley 415 rotatable by a drive cable 69, the pulley rotating the shaft through bevel gears 415, 416, a bellows coupling 419 and a pin 900. The shaft 412 is longitudinally oscillatable by an hydraulically oscillatable piston 436, coupled to the shaft 412 through a flexible tube 420, the coupling 419 facilitating this motion relative to the manipulator 38. Transverse oscillation of the shaft 412 is effected by hydraulically oscillatable pistons 429, 430 engaging opposed sides of the shaft 412, suitable transverse clearance being provided between the shaft and manipulator 38.