Patent SG-11201906139V-A (SG)
Title: Compositions and methods related to engineered fc constructs
Inventor: BOSQUES CARLOS J
IPC: A61K39/00
Filed: 2018-01-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 July 2018 (12.07.2018) WIP0 1 PCT ill mu °million °nolo omomiolol oimIE (10) International Publication Number WO 2018/129255 Al (51) International Patent Classification: A61K 39/00 (2006.01) C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) (21) International Application Number: PCT/US2018/012488 (22) International Filing Date: 05 January 2018 (05.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/443,495 06 January 2017 (06.01.2017) US 62/510,228 23 May 2017 (23.05.2017) US 62/589,473 21 November 2017 (21.11.2017) US (71) Applicant: MOMENTA PHARMACEUTICALS, INC. [US/US]; 301 Binney Street, Cambridge, MA 02142 (US). (72) Inventors; and (71) Applicants: BOSQUES, Carlos J. [US/US]; 40 Brat- tle Street, Apt. 7, Arlington, Massachusetts 02476 (US). LANSING, Jonathan C. [US/US]; 220 Woburn Street, Reading, Massachusetts 01867 (US). LING, Leona E. [US/US]; 45 Fells Road, Winchester, Massachusetts 01890 (US). MEADOR, III, James [US/US]; 38 Gryzboska Circle, Framington, Massachusetts 01702 (US). ORTIZ, Daniel [US/US]; 15 High Street, Stoneham, Massachusetts 02180 (US). RUTITZKY, Laura [US/US]; 70 Claren- don Avenue, Somerville, 02144 (US). SCHULTES, Brig- it [US/US]; 12 Monadnock Road, Arlington, Massachusetts 02476 (US). HUSTON, James S. [US/US]; 270 Pleasant Street, #A206, Watertown, Massachusetts 02472 (US). (74) Agent: ALPHA-COBB, Cambria et al.; Fish & Richard- son P.C., P. 0. Box 1022, Minneapolis, Minnesota 55440-1022 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: COMPOSITIONS AND METHODS RELATED TO ENGINEERED FC CONSTRUCTS FIG. 40 100 200 300 004 501 640 740 808 400 4000 1104 1202 7114 4 (Hoots) Post Doss 1-1 © (57) : The present disclosure relates to engineered IgG Fc constructs and uses thereof. C [Continued on next page] WO 2018/129255 Al MIDEDIM11110111101111101111111111111111111111111111111111101111111111111111111 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))