baber/WOPTO huggingface dataset:
Patent NZ-272274-A (NZ)
Title: Cytotoxic antibody drug conjugate
Inventor: HAMANN PHILIP ROSS
IPC: A61K47/48
Filed: 1995-06-02
Abstract: This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
Patent NZ-277258-A (NZ)
Title: Autidote organophosphoric cholinesterase inhibitors: at least one parasympathomimetic agent and one parasympatholytic agent
Inventor: HILLE THOMAS
IPC: A61K31/4425
Filed: 1994-12-06
Abstract: PCT No. PCT/EP94/04049 Sec. 371 Date Aug. 23, 1996 Sec. 102(e) Date Aug. 23, 1996 PCT Filed Dec. 6, 1994 PCT Pub. No. WO95/15756 PCT Pub. Date Jun. 15, 1995A pharmaceutical formulation for the prophylaxis and preliminary treatment of a poisoning caused by organophosphorus cholinesterase inhibitors is characterized in that it consists of an active substance combination of at least one parasympathomimetic and at least one parasympatholytic.
Patent NZ-290203-A (NZ)
Title: Stabilising the foam head of a beverage with pectin(s)
Inventor: WUBBEN MARIA ANNA
IPC: C12C11/11
Filed: 1995-08-03
Abstract: The invention provides pectins as new foam stabilizers for (temporary) foam heads in beverages, in particular in beers, especially beers of the pilsner type. These foam stabilizers are preferably obtained from hops, which is a constituent that is inherent in beer and accordingly offers the advantage, among others, that the foam stabilizers need to have no negative effect on the taste of the beer. Preferably, the pectins are obtained from hop cones or bines. It may be advantageous to partially saponify (de-esterify) the pectins, in connection with the number of charged groups on the pectins. In addition, the invention provides methods for obtaining the pectins and beverages stabilized with the pectins according to the invention.
Patent NZ-319495-A (NZ)
Title: Identification of, and uses for, nematicidal bacillous thuringiensis genes, toxins, and isolates
Inventor: FEITELSON JERALD S
IPC: C12Q1/68
Filed: 1996-10-01
Abstract: Disclosed and claimed are nucleotide primers for the identification of genes encoding toxins active against nematodes and coleopterans.  The primers are useful in PCR techniques to produce gene fragments which are characteristic of genes encoding these toxins.  The primers are also useful as nucleotide probes to detect the toxin-encoding genes.  The application also concerns isolates, toxins, and genes useful in the control of plant pests.
Patent NZ-330456-A (NZ)
Title: Indole-2,3-dione-3-oxime derivatives as excitatory amino acid antagonists and pharmaceutical compositions thereof for treating disorders
Inventor: WAETJEN FRANK
IPC: C07D487/04
Filed: 1997-10-01
Abstract: The present invention relates to novel indole-2,3-dione-3-oxime derivatives capable of antagonising the effect of excitatory amino acids, such as glutamate. More specifically the novel indole-2,3-dione-3-oxime derivatives of the invention may be described by general formula (I), wherein R3 represents "Het", or a group of formula (II), wherein "Het" represents a saturated or unsaturated, 4 to 7 membered, monocyclic, heterocyclic ring, at least one of R31, R32, and R33 independendy represents hydrogen, alkyl, or hydroxyalkyl, and at least one of R31, R32, and R33 independently represents (CH2)nR34; wherein R34 represents hydroxy, carboxy, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, cycloalkoxycarbonyl, cycloalkylalkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, CONR35R36, or "Het"; wherein n is 0, 1, 2, or 3; and R5 represents phenyl, naphthyl, thienyl, or pyridyl, all of which may be substituted. "A" represents a ring of five to seven atoms fused with the benzo ring at the positions marked "a" and "b", and formed by the following bivalent radicals: a-NR6-CH2-CH2-b; a-CH2-NR6-CH2-b; a-CH2-CH2-NR6-b; a-NR6-CH2-CH2-H2-b; a-CH2-NR6-CH2-CH2-b; a-CH2-CH2-NR6-CH2-b; a-CH2-CH2-CH2-NR6-b; a-NR6-CH2-CH2-CH2-CH2-b; a-CH2-NR6-CH2-CH2-CH2-b; a-CH2-CH2-NR6-CH2-CH2-b; a-CH2&mdas
Patent NZ-335543-A (NZ)
Title: Use of a collagen derivative as an fibroblast activation protein alpha (FAP-alpha) inhibitor
Inventor: ZIMMERMAN RAINER
IPC: C12N5/00
Filed: 1999-05-03
Abstract: Use of an inhibitor of FAP-alpha activity which interacts with molecules having FAP-alpha activity, said inhibitor being a collagen derivative, in the manufacture of a medicament for treating a subject with a pathological condition characterized by abnormal FAP-alpha activity.
Patent NZ-336304-A (NZ)
Title: Process for preparing particles covered with a layer of water glass and articles comprising such covered particles
Inventor: HUUSMANN OLE
IPC: B22C1/00
Filed: 1997-12-17
Abstract: A process for preparing particles covered with a layer of water glass, characterised by the steps of a) providing a mixture containing particles to be covered, water and 0.1-5% by weight water glass, calculated on the basis of the weight of the particles, the water glass having a weight module between 1.8 and 3.5, and being dissolved in the mixture; b) stirring the mixture mechanically, optionally supplying heat and permitting water to evaporate from the mixture until at least so much water is evaporated so that the mixture isn't sticky.
Patent NZ-500945-A (NZ)
Title: Fungicidal mixtures comprising a carbamate and 2-phenyl-pyrrole derivatives
Inventor: SCHELBERGER KLAUS
IPC: A01N47/24
Filed: 1998-05-15
Abstract: The fungicidal mixtures comprise:  a) a carbamate of the formula I, where: T is CH or N n is 0, 1 or 2 R is halogen, alkyl or haloalkyl, it being possible for the radicals R to be different if n is 2; and b) at least one active ingredient of the formula II or III in a synergistically effective amount. Also described is a method for controlling phytopathogenic fungi, which comprises treating the harmful fungi, their habitat or the plants, seeds, soils, areas, materials or spaces to be kept free from them with a compound of the formula I and at least one compound of the formula II or III in synergistically effective amounts.
Patent NZ-501194-A (NZ)
Title: Trousers with means to attach the inside to the outside of each trouser leg in the vicinity of the crutch
Inventor: DE BOOS ALLAN GIBSON
IPC: D06F35/00
Filed: 1998-05-19
Abstract: A method for improving the stability of the shape of trousers 10, particularly creases 15, when subjected to treatment with a fluid. During the treatment, the inside 12b and outside 12a of each leg 12 of the trousers are attached, at locations 18 on the respective legs which are on or adjacent the crutch 16 of the trousers. Attachment may be by means of a mechanical device such as a pin or staple.
Patent NZ-502144-A (NZ)
Title: Multi-subtype FIV vaccines
Inventor: YAMAMOTO JANET K
IPC: C12N7/01
Filed: 1996-08-23
Abstract: A vaccine composition comprising feline immunodeficiency virus (FIV) immunogens that are capable of eliciting and immune response against a plurality of FIV subtypes.  Also described is the use of the vaccine composition in the manufacture of a medicament, a method for determining the quantity of FIV neutralization antibodies in a sample and a method for inducing an immune response against FIV in a non-human host.
Patent NZ-506596-A (NZ)
Title: Compositions comprising an alpha1-adrenergic antagonist, sucralfate and a local anaesthetic and further comprising nitroglycerin
Inventor: FOGEL BARRY S
IPC: A61K31/445
Filed: 1999-02-25
Abstract: Described is the manufacture of medicaments for treating painful conditions of the anorectal region. The compositions include a combination of an alpha -adrenergic blocker and sucralfate, a combination of alpha -adrenergic blocker and lidocaine, and a combination of an alpha - adrenergic blocker, lidocaine, and sucralfate. Alternatively, the composition may contain only an alpha - adrenergic blocker. Additional active ingredients for reduction of anal pain may be added to the composition, particularly capsaicin. The compositions may be included in a petrolatum base along with a water-soluble lubricant. These compositions have been found effective in treating painful conditions in the anal region, such as anal fissures, inflamed or recently thrombosed haemorrhoids, and chronic anal pain.
Patent NZ-509409-A (NZ)
Title: A process for abrasive surface cleaning by fluidising organic particulate with dry gas
Inventor: UPTON ROSS
IPC: B24C1/00
Filed: 2001-01-17
Abstract: A process for the abrasive cleaning of a surface includes the steps of: dry fluidizing organic particulate media using a gas; and directing  the fluidized particulate/gas mixture to the surface.
Patent NZ-511523-A (NZ)
Title: Zinc finger binding domains for GNN
Inventor: BARBAS CARLOS F
IPC: C12Q1/6897
Filed: 1999-10-14
Abstract: Zinc finger-nucleotide binding polypeptides having binding specificity for target nucleotides containing one or more GNA triplets are provided. Compositions containing such polypeptides and the use of such polypeptides and compositions for regulating nucleotide function are also provided.
Patent NZ-511601-A (NZ)
Title: Multi-part electrical fitting having moulded compartments and an electrical connector
Inventor: SWIATEK THOMASZ
IPC: F16D1/10
Filed: 2001-05-09
Abstract: A multi-part electrical fitting (10) comprises first and second moulded components (11,14) having confronting wall portions (22, 23) and a connector element (24) arranged to engage with the confronting wall portions.  The moulded compartments include at least one groove (25,28) having an engagement portion (27,30).  The connector element has at least two limbs (32,33) and each limb is arranged to locate behind the respective wall portions of one of the moulded compartments to hold the wall portions in a confronting relationship.  The connector element has at least two fingers (34,35) located between the limbs and each finger is positioned on the connector element and is arranged to slide into a respective groove.  Each finger is provided with a lug (36) arranged to resiliently engage with the engagement portion in a respective groove to hold the connector element captive relative to the confronting wall portions of the moulded compartments.
Patent NZ-512475-A (NZ)
Title: Sheet metal bipolar plate design for polymer electrolyte membrane fuel cells
Inventor: MARIANOWSKI LEONARD G
IPC: H01M8/02
Filed: 1999-11-17
Abstract: Each fuel cell unit of a polymer electrolyte membrane fuel cell stack includes a membrane electrode assembly 20 with an anode electrode film on one face and a cathode electrode film on an opposite face, and anode current collector 26 and a cathode current collector 27 on the respective anode and cathode sides of the membrane electrode assemblies, and a separator plate 40 disposed between the anode electrode film side of one cell unit and the cathode electrode film side of an adjacent cell unit. The separator plate has guides, such as corrugations 60a, 60b for distributing fuel and oxidant gases to the anode electrode film side and the cathode electrode film side, respectively. The separator plate is constructed of at least two coextensive sheet metal elements (30, 31) having substantially identically shaped guides to promote the distribution of reactant gases to the electrodes of the fuel cell units of the fuel cell stack. The coextensive sheet metal elements are nestled together and form a coolant flow space (32) there-between.
Patent NZ-513461-A (NZ)
Title: Single stile ladder with rungs running continously from side to side for use against curved surfaces eg. tree trunks
Inventor: ORMSBY HANO
IPC: E06C7/08
Filed: 2001-10-09
Abstract: A portable ladder (10,20) assembly for use in climbing trees  or  poles  comprises at least of a first  and  second ladder.  Each  of  the ladders has a central  elongate  main member  (2) having first and second ends. Also, there  is  a plurality of transverse rungs (3) mounted on opposing  sides of  the main member between the first of second ends,  where each  of  the rung is hook-shaped. The ladder has a pair  of generally  parallel longitudinally extending spikes  at  the first  end of the main member (6). These spikes are  adapted to  be  inserted  into  spaced apart apertures  (5)  in  the second ladder's platform.
Patent NZ-516238-A (NZ)
Title: Article with tamper evident thermochromic ink layer and second ink layer
Inventor: KANNABIRAN RENGAN
IPC: B65D33/34
Filed: 2000-06-26
Abstract: An article, such as a tamper evident container, includes an indicator having a first layer including a thermochromic ink composition, and a second layer, disposed on the first layer, having a composition different from the ink composition of the first layer. The article exhibits better evidence of tampering. The first and/or second layer can be in the form of a message.
Patent NZ-521592-A (NZ)
Title: Reactor for treating a solid material such as wool fibers with a noxious gas or gaseous mixture, process and plant thereof
Inventor: LEMAN BERNARD
IPC: B01J15/00
Filed: 2001-03-28
Abstract: A reactor that operates in accordance with countercurrent and multiple effect principles, that comprises means for inputting gas, means for extracting gases derived from the treatment, means for introducing the material to be treated and means for removing the treated material, and means for transporting the material between its introduction and its removal, the means for introducing the gas and the means for removing the treated material being designed and arranged so that the gas is introduced into the reactor at the outlet for the treated material, and the means for extracting gases derived from the treatment and means for introducing the material to be treated being designed and arranged so that the gas mixture derived from the treatment is at the intake for the material to be treated. The Figure shows the reaction chamber (1) comprising sealed cells (2) where the multiple effect occurs, the tightness of which is ensured by the means of rollers (3) and the two porous conveyor belts captures the material travel on the porous support (4) creating a pressure drop which facilitates homogenous diffusion of the reactive gas through this material.
Patent NZ-524557-A (NZ)
Title: HIV regulatory and auxiliary peptides, antigens, vaccine compositions, immunoassay kit and a method of detecting antibodies induced by HIV
Inventor: SORENSEN BIRGER
IPC: G01N33/569
Filed: 2001-09-03
Abstract: A peptide derived from HIV-1 regulatory protein comprising at least one amino acid sequence which contains modifications compared with the native sequence; an antigen comprising at least on of the peptides; a vaccine comprising the antigen; antibodies capable of selectively reacting with the antigen; and a method for detecting the antibodies.
Patent NZ-529549-A (NZ)
Title: Antisense oligonucleotide against human acetylcholinesterase (ACHE) capable of crossing the blood brain barrier
Inventor: SOREQ HERMONA
IPC: A61P25/00
Filed: 2002-05-23
Abstract: Disclosed is a synthetic antisense oligodeoxynucleotide targeted against human acetylcholinesterase (AChE) mRNA having the nucleotide sequence: 5' CTGCCACGTTCTCCTGCACC 3' (SEQ ID NO:1. The antisense oligodeoxynucleotide can be used in the treatment and/prevention of neuromuscular disorders and in particular myasthenia gravis. In addition, it can penetrate the blood-brain barrier (BBB) and destroy AChE-R within the central nervous system neurons, while also serving as a carrier to transport molecules across the BBB.
Patent NZ-529876-A (NZ)
Title: Digital sounder module and method for detecting
Inventor: SOGAARD STEN
IPC: G01S7/526
Filed: 2003-12-01
Abstract: A digital sounder module (150) comprises: a sonar transducer (103) for transmitting an acoustic sonar wave at a selected frequency and pulse rate and for receiving echos of the transmitted acoustic sonar wave reflected from objects and for converting the received acoustic sonar wave into a first electrical signal; a band-pass filter (106) for providing a first wide bandpass filtration on the first signal to produce a second signal; an amplifier (110) for controlled amplification of the second signal to produce a third signal; the third signal being amplified carrier wave; an analog to digital converter (114) for receiving the amplified carrier wave , a rate at which the amplified carrier wave is converted to a digital signal by the analog to digital converter provides a harmonic sub-sampling , and the analog to digital converter transforms the amplified carrier wave into a digital intermediate frequency; a programmable logic device (118) for providing : (i) a variable gain control signal to the amplifier for normalization of the amplitude of reflected echos within the second signal by increasing gain in proportion to the distance of the echo reflection source from the sonar transducer; and (ii) the programmable logic device sets the harmonic sub-sampling rate cos Ô of the analog to digital converter such that the reflected transmitted acoustic sonar wave is above the Nyquist frequency; and a microprocessor (122) that provides an output for display (124) of the reflected echos.
Patent NZ-530599-A (NZ)
Title: Needle electrode for image-generating procedures with platinum-coated titanium body
Inventor: GRONEMEYER DIETRICH H W
IPC: A61N1/20
Filed: 2002-06-10
Abstract: Disclosed is a needle electrode for therapy, in particular for the percutaneous galvanotherapy of tumours, said electrode being suitable for representation in imaging methods. Said electrode has a coating consisting of platinum and/or an insulation material. The invention also relates to a method for producing the inventive needle electrode.
Patent NZ-531853-A (NZ)
Title: Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors)
Inventor: FREYEN EDDY JEAN EDGARD
IPC: A61K31/5377
Filed: 2002-10-29
Abstract: Disclosed are compounds of formula (I), wherein: R1 is H, R2 is a H, or optionally substituted monocyclic, bicyclic or tricyclic aromatic carbocycle, R3 is H, halo, alkyl, polyhalo-alkyl, or cyano, R4 is an optionally substituted monocyclic, bicyclic or tricyclic saturated heterocycle; a monocyclic, bicyclic or tricyclic partially saturated heterocycle or a monocyclic, bicyclic or tricyclic aromatic heterocycle, and the remaining substituents are defined herein. The compounds are used in the manufacture of medicaments for the treatment of diseases mediated through glycogen synthase kinase 3.
Patent NZ-539452-A (NZ)
Title: Coating compositions comprising alkyl ketene dimers and alkenyl succinic anhydrides for use in paper making
Inventor: PROPST CHARLES
IPC: D21H/
Filed: 2003-10-24
Abstract: Additives for paper making are disclosed herein. Specifically, the additives are wax-free alternatives to conventional coatings, including ASA, AKD and optionally an acrylic containing composition. Other additives may be included in the coating, such as cationic particles or compositions. The coatings may be used at a variety of points during the paper making process, including on the calender stack and in the wet end. The described process for making paper comprises the following steps: (A) applying a furnish to a wire; (B) dewatering the furnish and obtaining a water containing paper; (C) pressing the water containing paper to reduce the water content; (D) calendering the pressed paper; (E) recovering a finished paper; and (F) adding a coating, comprising an effective amount of at least one member selected from the group consisting of alkyl ketene dimer (AKD) and alkyl succinic anhydride (ASA) and optionally an acrylic acid containing composition. Particularly disclosed is a process for making paper wherein a furnish is deposited on a wire and dewatered, wherein the process comprises: adding to the furnish the following components: alkyl ketene dimer (AKD) in an amount of 1-20 dry lbs/ton of stock; an acrylic acid containing material in an amount of at least 35 dry lbs/ton of stock; and a cross-linking agent in an amount sufficient to cross-link the acrylic acid containing material, the cross-linking agent selected from the group consisting of ammonium oxide, calcium oxide, magnesium stearate, isostearate, calcium stearate, stannous oxide, tungsten oxide, titanium oxide, zinc octoate, aluminium oxide, aluminium stearate, zinc salts of fatty acids, zirconium oxide, calcium isostearate, calcium salts of fatty acids, magnesium salts of fatty acids, and aluminium salts of fatty acids; and wherein the acrylic acid containing material is cationic.
Patent NZ-548317-A (NZ)
Title: Spirocyclic cyclohexane derivatives with affinity for the ORL1-receptor
Inventor: HINZE CLAUDIA
IPC: A61K31/407
Filed: 2004-12-21
Abstract: The disclosure relates to spirocyclic cyclohexane derivatives of formula (I), wherein the substituents are as defined in the specification. Also disclosed is a method for the production thereof, to medicaments containing said derivatives and to the use of spirocyclic cyclohexane derivatives for the production of medicaments.
Patent NZ-554629-A (NZ)
Title: Nutritional composition comprising omega 3 fatty acids, for feeding infants whose mother suffered from diabetes or obesity
Inventor: STAHL BERND
IPC: A23L33/00
Filed: 2005-11-11
Abstract: Disclosed is the use of a liquid nutritional composition for feeding infants of a mother who suffered from one or more of diabetes type I, diabetes type II, obesity or overweight during pregnancy, said composition comprising an n-3 polyunsaturated fatty acid fraction containing at least 0.1 wt % docosahexaenoic acid (DHA) based on total weight of the lipid in the composition, at least 0.01 wt % n-3 docosapentaenoic acid (DPAn-3) based on total weight of the lipid in the composition, and at least 0.01 wt.% eicosapentaenoic acid (EPA) based on total weight of the lipid in the composition; wherein the sum of DHA, DPAn-3 and EPA is below 1 wt.% of total lipid in the composition and the following weight ratios are met: - EPA/DHA ratio is between 0.05 and 1; - (DPAn-3 + EPA)/DHA is between 0.25 and 1; - DPAn-3/EPA is between 0.25 and 5; and - DHA/DPAn-3 is between 2 and 25. Also disclosed is a nutritional composition wherein a carbohydrate provides 40 to 75 % of the total calories, a lipid provides 20 to 50 % of the total calories and a protein provides 5 to 12.5 % of the total calories, wherein the lipid contains at least one vegetable lipid source and a n-3 docosapentaenoic acid (DPAn-3) containing lipid source, said lipid contains a n-3 polyunsaturated fatty acid fraction and a n-6 polyunsaturated fatty acid fraction, wherein: a. the n-3 polyunsaturated fatty acid fraction contains - at least 0.1 wt % docosahexaenoic acid (DHA) based on total weight of the lipid in the composition; at least 0.01 wt % DPAn-3 based on total weight of the lipid in the composition; at least 0.01 wt% eicosapentaenoic acid (EPA) based on total weight of the lipid in the compostion; wherein the sum DHA, DPAn-3 and EPA is below 1 wt.% of total lipid in the composition; and - between 1.9 and 3 wt.% alpha linoleic acid (ALA) based on total weight of the lipid in the composition; and - the weight ratio: - EPA/DHA ratio between 0.05 and 1; - (DPAn-3 + EPA)/DHA between 0.25 and 1; - DPAn-3/EPA between 0.25 and 5; - DHA/DPAn-3 between 2 and 25; and - ALA/DHA between 5 and 25; and b. the n-6 polyunsaturated fatty acid fraction contains: - between 0.2 and 1 wt.% arachidonic acid (AA) based on total weight of the lipid in the composition; and - between 10 and 15 wt.% linoleic acid (LA) based on total weight of the lipid in the composition; c. a weight ratio LA/ALA between 5 and 10.