Patent SG-11201810757Y-A (SG)
Title: Non-human animals expressing exogenous terminal deoxynucleotidyltransferase
Inventor: MACDONALD LYNN
IPC: A01K67/027
Filed: 2017-06-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 December 2017 (07.12.2017) WiP0 I PCT 1111111111111111111011111111111111111131111 11M 101110111110# (10) International Publication Number WO 2017/210586 A8 (51) International Patent Classification: A01K 67/027(2006.01) C07K 16/46 C12N 9/12 (2006.01) C12N 15/90 C07K 16/00 (2006.01) C12N 15/85 (2006.01) (2006.01) (2006.01) (21) International Application Number: PCT/US2017/035731 (22) International Filing Date: 02 June 2017 (02.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/345,524 03 June 2016 (03.06.2016) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, NY 10591-6706 (US). (72) Inventors: MACDONALD, Lynn; c/o Regeneron Phar- maceuticals, Inc., 777 Old Saw Mill River Road, Tarry- town, NY 10591 (US). MURPHY, Andrew, J.; c/o Regen- eron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). GUO, Chunguang; c/o Re- generon Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). LEVENKOVA, Natasha; c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). TU, Naxin; c/o Regen- eron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). MCWHIRTER, John; c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). VORONINA, Vera; c/ o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill Riv- er Road, Tarrytown, NY 10591 (US). HARRIS, Faith; c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (48) Date of publication of this corrected version: 03 May 2018 (03.05.2018) (15) Information about Correction: see Notice of 03 May 2018 (03.05.2018) (74) Agent: JONES, Brendan, T. et al.; Foley, Hoag LLP, 155 Seaport Boulevard, Boston, MA 02210-2600 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 11 TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 1-1 N 1-1 (54) Title: NON-HUMAN ANIMALS EXPRESSING EXOGENOUS TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE O ei (57) : Provided herein are methods and compositions related to non-human animals that express exogenous Terminal De- C oxynucleotidyltransferase (TdT).