baber/WOPTO huggingface dataset:
Patent CA-2318160-A1 (CA)
Title: Asymmetric cyanine dye quenchers
Inventor: HAXO FRANCIS T
IPC: C07D417/06
Filed: 1999-01-19
Abstract: The invention provides an asymmetric cyanine dye compound having structure (1) including substituted forms thereof, wherein, at least one of R1 and R2 is linking group. X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labeled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labeled polynucleotides.
Patent CA-2319137-A1 (CA)
Title: Planar patterns with superimposed diffraction grating
Inventor: STAUB RENE
IPC: G06K19/16
Filed: 1999-01-21
Abstract: A surface pattern (1) is composed of elements (2 to 5) which are arranged in a mosaic-like fashion and of which at least one pattern is formed from a background element (4) and a pixel (2) with microscopically fine relief structures diffracting visible light. The surface elements (3) and the element portions (5) either contain the microscopically fine relief structures diffracting visible light or they comprise reflecting or scattering surfaces. Arranged in the pixel (2) is a first diffraction grating B1 and arranged in the background element (4) is a second diffraction grating B2, wherein the first diffraction grating B1 and the second diffraction grating B2 are a superimposition of at least two different, microscopically fine relief structures F1 and F2 diffracting visible light. The first diffraction grating and the second diffraction grating B2 differ only by virtue of a relative phase shift .DELTA..phi. between the relief structure F1 and the relief structure F2. Upon illumination with polychromatic light the pattern is of a single color which has brightness differences in zones involving different values of the phase shift .DELTA..phi..
Patent CA-2320044-A1 (CA)
Title: Traitement de la sclerose en plaques en utilisant le cop-1 et les cytokines de renforcement des th2
Inventor: SLAVIN ANTHONY
IPC: A61K38/00
Filed: 1999-02-12
Abstract: La présente invention concerne un traitement de la sclérose en plaques. Pour ce faire, on administre par voie muqueuse à des patients souffrants de cette maladie le COP-1 (copolymère-1), un polymère synthétique renfermant un mélange de polypeptides synthétiques aléatoires constitués de L-alanine, L-acide glutamique, L-lysine et L-tyrosine dans un rapport molaire d'environ 6:2:5:1, conjointement avec des cytokines de renforcement des Th2, telles que IL-4 ou IL-10. Le traitement combiné de Il-4 ou de IL-10 (administré de préférence par voie orale) et du COP-1 administré par voie muqueuse, présente un effet inhibiteur sensiblement plus important que le traitement par les cytokines ou le COP-1 seul.
Patent CA-2325578-A1 (CA)
Inventor: OLSON DAVID B
IPC: C08K5/20
Filed: 1998-08-10
Abstract: An ultraviolet light absorbing material that resists blooming and migration is made up of a fluoropolymer and an amide functional ultraviolet light absorbing compound, wherein the polymer and the amide functional ultraviolet light absorbing compound are hydrogen bonded to one another. Polymeric films that contain a polymeric matrix and the ultraviolet light absorbing material are useful as the top layer in multilayer constructions such as retroreflective sheetings and conformable marking sheets.
Patent CA-2327340-A1 (CA)
Inventor: HEIDECK GUNTER
IPC: F24F7/06
Filed: 2000-01-25
Abstract: The invention relates to a mechanical smoke and heat evacuation system for removing smoke from structural works, for example, from buildings and tunnels, among other things, in order to make it possible for people to escape from areas containing smoke and heat and/or harmful gases or aerosols as well as making it possible for rescue workers to enter these structural works or to permit the fire department to carry out a targeted extinguishing offensive. The aim of the invention is to create a mechanical smoke and heat evacuation system which is comprised of a suction pressure generator and of a power supply and whose operation is ensured independent of the amount of smoke and heat produced by the fires. The system should consist of robust components which are insensitive to temperature, smoke and other harmful substances. In addition, the system should offer a higher suction volume per unit of time by order of magnitude. According to the invention, a gas jet or steam jet vacuum pump (7) is provided as a suction pressure generator whose impelling side is connected to a gas or steam supplier. A gas jet propulsion mechanism (8) can be used, for example, as a gas supplier. The system can be operated in both a stationary as well as mobile manner.
Patent CA-2330796-A1 (CA)
Title: Derives d'indole agissant comme des ligands de 5-ht2a et comme des inhibiteurs de reabsorption de la serotonine
Inventor: GALLAGHER PETER THADDEUS
IPC: A61K31/4439
Filed: 1999-05-11
Abstract: L'invention concerne des composés pharmaceutiques ayant la formule (I) dans laquelle n est compris entre 1 et 6, m est 1 ou 2 et p est 1 ou 2. R?1¿ et R?2¿ sont chacun hydrogène, alkyle C¿1-4?, alcoxy C¿1-4?, alkyle HO-C¿1-4?, alkyle C¿1-4? - alcoxy C¿1-4?, alkylthio C¿1-4?, halo, phényle éventuellement substitué, phényle - alkyle C¿1-4? éventuellement substitué, ou R?1¿ et R?2¿ sont pris conjointement avec l'atome de carbone auquel ils sont attachés pour former un groupe cycloalkyle C¿3-6?, ?C=O, C=NOR', où R' est hydrogène ou alkyle C¿1-4? ; R?3¿, R?4¿ et R?5¿ sont chacun hydrogène, halo, nitro, alkyle C¿1-4?, alcoxy C¿1-4?, -CO- alkyle C¿1-4?, où m est 0, 1 ou 2, R'R''N-SO¿2?-, -COOR', -CONR'R'', -NR'R'', -N(OR')COOR'', -COR', -NHSO¿2?R', où R' et R'' sont chacun hydrogène ou alkyle C¿1-4? ; R?6¿ et R?7¿ sont chacun hydrogène ou alkyle C¿1-4?, x est oxygène ou soufre, la ligne en pointillé représente une éventuelle liaison double dans les positions 6- et 7-. L'invention concerne également les sels de ces compositions.
Patent CA-2331564-A1 (CA)
Title: Magnetron sputter source for mbe apparatus
Inventor: WEBB JAMES
IPC: C30B23/02
Filed: 2001-01-18
Abstract: A magnetron sputter source is adapted to fit into a K-cell port in a molecular beam epitaxy apparatus. The MSE source has a protruding cylindrical body for insertion into the K-cell port. The cylindrical body is attached at its proximal end to a flange and has its distal end open. An array of permanent magnets is arranged at the distal end of the cylindrical body. A magnet return piece is mounted behind the permanent magnets. A sputter target is mounted in front of the permanent magnets, and cooling ducts within the cylindrical body carry a cooling medium to the sputter target.
Patent CA-2332248-A1 (CA)
Inventor: LI KENNETH K
IPC: G02B6/38
Filed: 1999-06-04
Abstract: A proximal connector includes a stainless steel, cone-shaped ferrule enclosing a proximal end of the optic fiber element. The ferrule is inserted within a matching aperture of a receiving block, which is also made of stainless steel.  The matching shapes of the ferrule and the aperture of the receiving block ensure effective heat transfer from the ferrule into the receiving block. The receiving block may be provided with cooling vanes, and air may be circulated over the cooling vanes, to dissipate heat transferred to the receiving block from the connector. Both ferrule and the aperture are axially symmetric such that any rotation of the proximal connector while inserted into the receiving block does not change the location of the entrance aperture of the optic fiber element. The proximal connector also includes a case having an indented ring.  A ball plunger biasing mechanism is mounted within the aperture of the receiving block and is positioned to engage the indented ring only while the proximal connector is fully and securely inserted within the aperture. The plunger prevents accidental removal of the proximal connector while also providing a biasing force for ensuring solid contact between the cone-shaped ferrule and the corresponding portions of the receiving block to further facilitate heat conduction. The concept may be extended to provided adaptor connectors which couple such proximal connectors to an appropriately configured receiving block.
Patent CA-2341818-A1 (CA)
Title: Energy conversion apparatus
Inventor: NANDA AMAR KANT
IPC: H02J7/02
Filed: 2001-03-22
Abstract: An energy conversion apparatus comprising a heat conductive base, a heat insulating cover operable to mate with the base so as to form a sealed space bounded by the cover and the base to prevent ingress of moisture, and a mount inside the space, for securing an energy conversion circuit to at least one of the cover and the base.
Patent CA-2341822-A1 (CA)
Title: Solid state liquid level sensor and pump controller
Inventor: WYATT ARNOLD G
IPC: F04B49/025
Filed: 2001-03-22
Abstract: A liquid level controller for a device having a liquid reservoir includes a control board and a reservoir assembly. The reservoir assembly is disposed within the reservoir and includes a liquid level sensor, which is electrically connected to the control circuit.  The control board includes a control circuit and a pump. The control circuit has a control circuit and a resistive power supply to power the control circuit. The control circuit controls the pump in response to signals from the level sensor and includes a CMOS logic gate and a MOSFET  transistor to switch the pump. The control circuit further includes a second resistive power supply connected to a relay which controls an alarm. The second power supply is activated by a transistor responsive to an alarm signal from the level sensor, and powers the relay only when the alarm signal is present.
Patent CA-2341893-A1 (CA)
Title: Support pour timbres auto-encreurs
Inventor: BERTONI ROBERTO
IPC: B41K1/58
Filed: 2000-04-18
Abstract: L'invention concerne un support pour timbres auto-encreurs, ces timbres comprenant une enveloppe ou une gaine en forme de boîte avec au moins deux côtés opposés sur lesquels sont ménagées des ouvertures, et un curseur contenant un élément de timbrage renversé et un tampon encreur, qui coulissent de manière élastique à l'intérieur de ladite enveloppe ou gaine, entre les ouvertures. Ce support est constitué d'un montant (1) et d'une pluralité d'extensions principales (3) qui s'ouvrent de manière oblique, afin d'être parallèles à au moins une surface dudit montant, chacune de ces extensions étant par ailleurs capable de porter un timbre. Un organe de retenue (4) est en outre associé à chaque extension principale (3) de manière à reposer contre l'enveloppe ou la gaine une fois soutenu respectivement par une extension principale du côté opposé, ce qui permet d'appuyer solidement le timbre sur celle-ci.
Patent CA-2344089-A1 (CA)
Title: Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues
Inventor: FOSSA ANTHONY ANDREA
IPC: A61K38/27
Filed: 2001-04-12
Abstract: This invention is directed to pharmaceutical compositions comprising corticotropin releasing factor antagonist and growth hormone or growth hormone secretagogues, prodrugs thereof, or pharmaceutically acceptable salts of said compounds or said prodrugs. The invention is also directed to methods of treating heart related diseases (including congestive heart failure) in mammals, and particularly in humans.
Patent CA-2344986-A1 (CA)
Title: Disposable centrifuge cartridge backed up by reusable cartridge casing in a centrifugal filter for removing soot from engine oil
Inventor: BROWN GENE W
IPC: B04B1/04
Filed: 2001-04-25
Abstract: A centrifuge filter for removing soot from engine oil. The centrifuge filter includes a rotor adapted to be rotated inside a centrifuge housing by an electric motor or other means. The rotor preferably includes a reusable aluminum support casing and a disposable plastic cartridge. The plastic cartridge includes a trap with partition walls to prevent wave formation in the rotating liquid contained in the trap. The cartridge includes an annular inlet through its top end, a winding flow path through the cartridge and an outlet at the bottom enc. The centrifuge housing includes an isolated sealed rotor chamber. Using the venturi effect, air is evacuated from the rotor chamber to provide a partial vacuum to reduce air drag on the rotor. Resilient rubber vibration isolators are used to reduce vibrations and engine induced shock loads from reaching the rotating element. A side oil inlet is provided in the cartridge to receive unfiltered oil at a location offset from the axis of rotation. Oil is feed in through the top of the centrifuge cartridge and discharged out the bottom. The rotor is carried by bearings on a stationary central support shaft. Maintenance is performed through a removable lid on the top end of the rotor. A restriction plug is used to control flow into the rotor.
Patent CA-2345169-A1 (CA)
Title: Distributed channel assignment method
Inventor: AVIDOR DAN
IPC: H04W4/00
Filed: 2001-04-25
Abstract: Without intercell coordination on a per communication request basis, channel assignment can be efficiently performed by developing for each cell, or a sector thereof when the cells are sectorized using directional antennas, a priority list of groups of channels, and selecting a channel to be assigned in response to a request for service from the highest priority group which has available channels at the time of the service request. The priority lists are developed based on various interference measurements that are made. The priority lists tend to remain the same for relatively long periods of time. However, periodically, the priority lists should be redetermined to insure that the best lists are being employed. For example the lists may need to be changed due to new construction or to seasonal vegetation changes, which may affect the interference experienced in the system. Advantageously, system capacity under peak concentrated load conditions may increase. This advantage is further magnified under field conditions for which the cell shapes are not ideal.
Patent CA-2346200-A1 (CA)
Inventor: KONKIN DOUGLAS
IPC: H04Q11/06
Filed: 2001-05-02
Abstract: A time:space:time switch fabric incorporating an odd integer number of spatially distributed data switches and a plurality of spatially distributed data serializers. Each data switch has a first plurality of ingress ports, an equal plurality of egress ports, and a space switch for selectably interconnecting any one of the ingress ports to any one of the egress ports. Each data serializes has an input bus for receiving signals to be routed through the switch fabric, an output bus for outputting signals routed through the switch fabric, a plurality of egress ports select-ably connectable to any one of the data switch ingress ports, and an equal plurality of ingress ports selectably connectable to any one of the data switch egress ports. The ingress/egress ports are characterized by: (A) p planes, where p is a power-of-two integer less than or equal to the number of data serializer ingress and egress ports; (B) s stages, where s is an odd integer number; and, (C) a depth d, where d is a power-of-two integer less than or equal to the number of data switch ingress and egress ports.
Patent CA-2348837-A1 (CA)
Title: Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
Inventor: FRIEND STEPHEN H
IPC: C12Q1/68
Filed: 1999-10-27
Abstract: The present invention provides methods for enhanced detection of biological response patterns. In one embodiment of the invention, genes are grouped into basis genesets according to the co-regulation of their expression. Expression of individual genes within a geneset is indicated with a single gene expression value for the geneset by a projection process. The expression values of genesets, rather than the expression of individual genes, are then used as the basis for comparison and detection of biological response with greatly enhanced sensitivity. In another embodiment of the invention, biological responses are grouped according to the similarity of their biological profile. The methods of the invention have many useful applications, particularly in the fields of drug development and discovery.  For example, the methods of the invention may be used to compare biological responses with greatly enhanced sensitivity. The biological responses that may be compared according to these methods include responses to single perturbations, such as a biological response to a mutation or temperature change, as well as graded perturbations such as titration with a particular drug. The methods are also useful to identify cellular constituents, particularly genes, associated with a particular type of biological response.  Further, the methods may also be used to identify perturbations, such as novel drugs or mutations, which effect one or more particular genesets. The methods may still further be used to remove experimental artifacts in biological response data.
Patent CA-2353059-A1 (CA)
Title: Hammer
Inventor: LIN WU LI-TU
IPC: B25G1/01
Filed: 2001-07-13
Abstract: A hammer includes a composite material handle having a connecting portion formed on one end of the composite material handle. A head is encircled in the connecting portion of the handle and has a flat working face formed on one end. An annular groove is defined in a middle portion of the head to receive the connection portion of the handle. A through hole is transversely defined in the middle portion of the head and communicates with the annular groove. A cushion core is securely inserted in the through hole in the head to absorb the shock generated when the hammer is used.
Patent CA-2353643-A1 (CA)
Inventor: VAN GIJLSWIJK ROBERTUS PETRUS
IPC: C12Q1/6816
Filed: 1999-12-03
Abstract: The invention provides methods and means for generating interstrand cross-links in nucleic acid at certain specific locations in said nucleic acid. Said certain specific locations in said nucleic acid can be selected from other locations through hybridising nucleic acid present in said selected location with complementary nucleic. In one aspect the invention provides a method for providing at least one selected sequence in a nucleic acid with interstrand cross-links comprising hybridising at least one selected single strand sequence with a complementary single strand nucleic acid wherein said selected sequence or said complementary nucleic acid or both comprise a cross-linking agent. The means and methods of the invention may be used in and beneficial for a wide variety of applications, such as the generation of nucleic acid probes and the treatment of diseases such as cancer.
Patent CA-2353984-A1 (CA)
Inventor: VAUGHN GLEN A
IPC: C22C38/14
Filed: 1999-12-16
Abstract: Acier peu allié, soudable et extrêmement résistant présentant une résistance excellente aux températures cryogéniques dans la plaque de base et dans la zone touchée par la chaleur (HAZ) quand il est soudé et possédant une résistance à la traction supérieure à 830 MPa (120 ksi), ainsi qu'une microstructure composée essentiellement (i) d'austénite inférieure à grains fins, de martensite à grains fins stratifiée, de bainite à grains fins (FGB) ou de leurs mélanges et (ii) de jusqu'à 10 % en volume d'austénite retenue. Sa préparation consiste à réchauffer un lingot d'acier contenant du fer et des pourcentages en poids spécifiques de quelques uns ou de la totalité des additifs, tels que carbone, manganèse, nickel, azote, cuivre, chrome, molybdène, silicium, niobium, vanadium, titane, aluminium et bore; à réduire le lingot, de manière à obtenir une plaque dans une ou plusieurs passes dans une plage de température de recristallisation de l'austénite; à effectuer le laminage final de la plaque dans une ou plusieurs passes dans une plage de température inférieure à la température de recristallisation de l'austénite et supérieure à la température de transformation d'Ar 3; à effectuer la trempe de la plaque laminée finie à une température d'arrêt de trempe (QST) appropriée; à arrêter la trempe et soit, pendant une certaine durée, à maintenir la plaque en isothermie à la température d'arrêt de trempe (QST), soit à la refroidir lentement avant son refroidissement à l'air, ou simplement à la refroidir à l'air à température ambiante.
Patent CA-2356188-A1 (CA)
Inventor: PETERSEN HANS
IPC: C07D307/88
Filed: 1999-12-22
Abstract: A method for the preparation of 5-cyanophthalide in which 5-carboxyphthalide  is converted to the corresponding amide of Formula (IV) in which R is hydrog en or C1-6 alkyl, which is then reacted with a dehydrating agent thereby obtaining 5-cyanophthalide. The conversion of 5-carboxyphthalide to the corresponding amide of Formula (IV) may be carried out via the corresponding  C1-6 alkyl or phenyl ester or the acid chloride, which is converted to the amide of Formula (IV) by amidation with ammonia or a C1-6 alkylamine. By the  process 5-Cyanophtalide, an important intermediate used in the preparation o f the antidepressant drug citalopram, is prepared in high yields by a convenient, cost effective procedure.
Patent CA-2358655-A1 (CA)
Title: Lighten cement slurries
Inventor: NOIK CHRISTINE
IPC: C09K8/46
Filed: 2001-10-05
Abstract: Cement emulsion contains cement, at least one mineral filler, water and resin particles (VASA) obtained by polymerisation of vinyl aromatic, alkyl acrylate or acrylic monomers, which are optionally crosslinked.
Patent CA-2359345-A1 (CA)
Inventor: DOHERTY DANIEL H
IPC: A61K47/48
Filed: 2000-01-14
Abstract: L'invention concerne des techniques qui permettent de produire des protéines solubles contenant des cystéines libres. Selon lesdites techniques, on expose une cellule hôte à un agent bloquant la cystéine, puis on modifie éventuellement les protéines solubles obtenues afin d'accroître leur efficacité. Ces modifications peuvent consister à fixer un groupe PEG afin de former des protéines pégylées.
Patent CA-2362943-A1 (CA)
Inventor: ANDREEV JULIAN
IPC: A61P29/00
Filed: 2000-02-18
Abstract: The present invention relates to novel Pyk2 binding proteins Pap alpha and Pap beta, nucleotide sequences encoding the novel Pyk2 binding proteins, as well as various products and methods useful for the diagnosis and treatment of various Pyk2 binding protein-related and protein kinase-related diseases and conditions. Through the use of a bioinformatics strategy, two mammalian members of the Pyk2 binding protein family have been identified and their protein structure predicted.
Patent CA-2365190-A1 (CA)
Title: Novel polypeptide
Inventor: FIDOCK MARK DAVID
IPC: A61K48/00
Filed: 2001-12-14
Abstract: Polynucleotide and polypeptide sequences are described. The polypeptide sequences comprise one or more of: (a) a polypeptide having the deduced amino acid sequence translated from the polynucleotide sequence in SEQ ID NO: 1 and variants, fragments, homologues, analogues and derivatives thereof; (b) a polypeptide of SEQ ID NO:  2 and variants, fragments, homologues, analogues and derivatives thereof.
Patent CA-2366356-A1 (CA)
Inventor: LEE SUNG-WON
IPC: H04W16/02
Filed: 2001-01-15
Abstract: There is provided a supplemental channel assigning apparatus and method in a mobile communication system. In the supplemental channel assigning method, a mobile station receives a plurality of supplemental channel assignment messages successively from a base station on an existing traffic channel and stores the received channel assignment messages in a memory according to the duration and sequence numbers of the channel assignment messages. The mobile station then conducts data communication on a channel corresponding to the channel identifier of a first read channel assignment message for a period between the start time and the end of the duration set in the read channel assignment message and then on a channel corresponding to the channel identifier of a next read channel assignment message for a period between the start time and the end of the duration set in the next channel assignment message.