Patent SG-11201901220X-A (SG)
Title: Methods of processing a fluid including a recombinant therapeutic protein and use thereof
Inventor: VETTER TARL
IPC: C07K1/34
Filed: 2017-08-15
Abstract: RetentateFeed FIG. (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 February 2018 (22.02.2018) WIPO I PCT omit IIl °nolo III ll Oil IIII iflo oimIE (10) International Publication Number WO 2018/035116 Al (51) International Patent Classification: CO7K 1/34 (2006.01) (21) International Application Number: PCT/US2017/046930 (22) International Filing Date: 15 August 2017 (15.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/375,689 16 August 2016 (16.08.2016) US (71) Applicant: GENZYME CORPORATION [US/US]; 500 Kendall Street, Cambridge, Massachusetts 02142 (US). (72) Inventors: VETTER, Tarl; c/o Sanofi, 55 Corporate Dri- ve, Mail Code: 55A-505A, Bridgewater, New Jersey 08807 (US). COOLBAUGH, Michael; c/o Sanofi, 55 Corpo- rate Drive, Mail Code: 55A-505A, Bridgewater, New Jer- sey 08807 (US). WARIKOO, Veena; 6 Hawthorne Ave, Westford, Massachusetts 01886 (US). KONSTANTINOV, Konstantin; 521 Chestnut Street, Waban, Massachusetts 02468 (US). (74) Agent: REITER, Tiffany; Fish & Richardson P.C., P.O. Box 1022, Minneapolis, Minnesota 55440-1022 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) (54) Title: METHODS OF PROCESSING A FLUID INCLUDING A RECOMBINANT THERAPEUTIC PROTEIN AND USE THEREOF 1-1 (57) : Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a © tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Also provided are i ntegrated and continuous processes for manufacturing a therapeutic protein drug substance that include a step of processing a fluid including the recombinant therapeutic protein using any of the methods provided herein.