baber/WOPTO huggingface dataset:
Patent EA-002370-B1 (EA)
Title: Process for the preparation of simvastatin and derivatives thereof
Inventor: ZUPANCIC SILVO
IPC: C07F7/18
Filed: 1999-02-24
Abstract: 1. A process for the preparation of compounds of formula (I)   wherein R is an alkyl group having 1-12 carbon atoms R1 is a protecting group or H which process comprises (a) converting the diol lactone of formula (II)   to the protected diol lactone of formula (IIa) wherein R1 is a protecting group   (b) acylating the protected diol lactone (IIa) to give compound (I) wherein R1 is a protecting group, (c) optionally removing the protecting group R1 to give compound (I) wherein R1 is H; and wherein steps (a) and/or (b) are carried out in the presence of N-methylimidazole. 2. The process according to claim 1, wherein the N-methylimidazole is used in an amount sufficient to dissolve at the reaction temperature the diol lactone (II) and the protected diol lactone (IIa). 3. The process according to claim 1 or 2, wherein the protecting group R1 is a silyl group and in particular a trialkyl silyl group. 4. The process according to claims 1 to 3, wherein tert.-butyldimethylsilyl is used as protecting group R1. 5. The process according to claims 1 to 4, wherein in step (b) the protected diol lactone (IIa) is acylated with an activated form of the acid of formula (III) R--CO-OH                                (III) and R is as defined in claim 1. 6. The process according to claim 5, wherein an acid halogenide of formula (IIIa) R--CO-halogen                          (IIIa) or acid anhydride of formula (IIIb) (R--CO)2 O                                (IIIb) is used as activated form of the acid (III). 7. The process according to claim 6, wherein an acid chloride is used as an acid halogenide. 8. The process according to claim 1, wherein after completion of step (b) an aliphatic alcohol, having 1-8 carbon atoms, is added to the reaction mixture. 9. The process according to claims 1 to 8, wherein methanol is used as the aliphatic alcohol. 10. The process according to claims 1 to 9, wherein steps (a) and (b) are carried out as a one-pot reaction without isolating the protected diol lactone (IIa). 11. The process according to claims 1 to 10, wherein steps (a) and/or (b) are carried out at a temperature of about 0 to about 30 degree C. 12. The process according to claims 1 to 11, wherein R is an alkyl group having 5 carbon atoms, preferably is CH3 -CH2 --C(CH3)2.
Patent EA-009886-B1 (EA)
Title: Pharmaceutical composition for the prophylaxis or treatment of cardiovascular, cardiopulmonary, pulmonary or renal diseases
Inventor: RIEDEL AXEL
IPC: A61K31/401
Filed: 2004-01-14
Abstract: The invention relates to a method for the prophylaxis or treatment of cardiovascular, cardiopulmonary, pulmonary or renal diseases, achieved by the improvement of endothelial function and the protection of organs, tissues and vessels when indications require a blood pressure check and a lipid level check, especially in patients that have been diagnosed with type 2 diabetes mellitus or if prediabetes is suspected. Said method is also used for preventing diabetes and prediabetes and for the treatment of metabolic syndrome and insulin resistance in patients with normal blood pressure. Said method involves the common administration of effective quantities of telmisartan or a polymorph or salt thereof and simvastatin. The invention also relates to suitable pharmaceutical compositions, containing telmisartan or a polymorph or salt thereof and simvastatin, as a combined preparation for simultaneous, separate or sequential use in the prophylaxis or treatment of said diseases.
Patent EA-011585-B1 (EA)
Title: Mixtures of anthranilamide invertebrate pest control agents
Inventor: ANNAN ISAAC BILLY
IPC: A01N43/56
Filed: 2005-07-22
Abstract: Disclosed are mixtures and compositions for controlling invertebrate pests relating to combinations comprising (a) 3-bromo-N-[4-cyano-2-methyl-6[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, an N-oxide, or a salt thereof, Formula (1) and (b) at least one invertebrate pest control agent selected from neonicotinoids, cholinesterase inhibitors, sodium channel modulators, chitin synthesis inhibitors, ecdysone agonists, lipid biosynthesis inhibitors, macrocyclic lactones, GABA-regulated chloride channel blockers, juvenile hormone mimics, ryanodine receptor ligands, octopamine receptor ligands, mitochondrial electron transport inhibitors, nereistoxin analogs, pyridalyl, flonicamid, pymetrozine, dieldrin, metaflumizone, biological agents, and salts of the foregoing. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a mixture or composition of the invention.
Patent EA-011001-B1 (EA)
Title: Perforable closure for a container, mould and method for manufacturing said closure
Inventor: CONSOLARO ROBERTO
IPC: B65D47/36
Filed: 2006-07-18
Abstract: A perforable closure for a container, is provided with at least a annular portion (2) fit to joint the container and connected to an end portion (3), perforable by means of a perforator (P) of an outflow or the like. At least the annular (2) and end (3) portions of said closure (1) are integral.
Patent EA-015800-B1 (EA)
Title: Novel enzymes for use in enzymatic bleaching of food products
Inventor: ZORN HOLGER
IPC: A23L5/40
Filed: 2006-07-12
Abstract: The present invention relates to novel polypeptides according to caroase 01-05 or any functional equivalents of any of them, suitable for use in a method for preparing a food products having increased whiteness, the use of the enzyme to increase whiteness of at least part of a food product, a process for preparing a food product wherein the enzyme is used and the food product obtained.
Patent EA-012867-B1 (EA)
Title: Device for securing a furnace provided with a rapid cooling and heating system operating under controlled atmosphere
Inventor: CLUZEL XAVIER
IPC: F27D99/00
Filed: 2007-06-26
Abstract: A device enabling limitation of the risk of formation of an explosive atmosphere in the furnace of a continuous heat treatment line of metal strips the sections of which are under an atmosphere consisting of a mixture of inert gas and hydrogen the hydrogen volume content of which is between 5 and 100%, provided with a rapid induction heating section and a rapid cooling section comprising: a chamber (9) maintained under inert gas at the inlet of the rapid heating section of the furnace and at the outlet of the rapid cooling section, the pressure in the chamber (9) being equal to or greater than the atmospheric pressure when the heating of the furnace operates normally; a device (10) for entering the strip into the chamber (9), from the atmospheric air; a device (11) for atmosphere separation and for entering the strip in the heating section of the furnace from the chamber (9) under inert gas, said device (11) being provided with a gas take-off (4); a device (13) for atmosphere separation and for removing the strip from the rapid cooling section of the furnace, provided with a gas take-off (14), and a device (12) for removing the strip from the chamber (9) towards the atmospheric air.
Patent EA-017012-B1 (EA)
Title: Method for putting down installation for harvesting mollusks to the sea
Inventor: MOGUCHEV VALERIJ PETROVICH
IPC: A01K61/00
Filed: 2010-04-30
Abstract: A method is proposed for putting down an installation for mollusk harvesting comprising a carrying rope with two and anchors (18) and a plurality of growing elements (1) subsequently attached on the carrying rope by their bottom ends and directed by their upper ends upwards after putting installation in the sea. The installation is assembled on the vessel board, wherein the growing elements (1) are suspended on an extended guide (28) by their upper ends and are fixed on the supporting rope by their bottom ends, and when putting the installation down to the sea the suspended growing elements (1) are moved along the extended guide (28) towards vessel stern and are removed from the extended guide (28) behind the vessel stern with subsequent dropping to the sea due to movement of the carrying rope drawn to the sea after dropping the first end anchor (18). The method provides showering suspended growing elements (1) by sea water and allows to avoid tangling installation elements and to reduce death and damage of young mollusks when putting down the installation to the sea.
Patent EA-016979-B1 (EA)
Title: System and method for migrating seismic data
Inventor: WANG YUE
IPC: G01V1/28
Filed: 2009-03-06
Abstract: A system and method that enable the processing of seismic data. In one embodiment, a system comprises a plurality of processing nodes and a server. The plurality of processing nodes are configured to process seismic data for migration. The server is operatively linked to each of the plurality of processing nodes to enable communication between the server and the processing nodes. The server may manage a set of stored beam tables that can be accessed by the processing nodes in order to process seismic data.
Patent EA-020591-B1 (EA)
Title: Rosuvastatin derivatives
Inventor: LINDSAY DEREK
IPC: A61P9/10
Filed: 2010-03-10
Abstract: This invention relates to rosuvastatin analogues of general formula I and pharmaceutically acceptable salts and solvates thereofwherein A isand the rest substituents have meanings described herein in the description. The compounds of the present invention are active in inhibiting the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and can be used for the treatment of disease states modulated by HMG-CoA reductase.
Patent EA-020423-B1 (EA)
Title: Anode current lead of aluminium electrolytic cell
Inventor: POLJAKOV PETR VASILIEVICH
IPC: C25C3/16
Filed: 2011-11-03
Abstract: The invention relates to non-ferrous metallurgy, in particular, to electrolytic production of aluminium, mainly to design of anode current lead of aluminium electrolytic cell. The inventive result provides increased contact area of the carbon anode with the current lead, prevention of formation of cavities in the anode and reduction of the anode electrical resistance. The invention is characterized in that the anode current lead of aluminium electrolytic cell consisting of a vertically incremental rod is made of ceramic open-porous and isotropic-structured elements with a porosity of at least 70% and joined at the junction creating electrical contact and with pore sizes of less than 5 microns, based on aluminium oxide and the components that increase a wetting ability of aluminium, while the pores are filled with aluminium or aluminium alloys.
Patent EA-020931-B1 (EA)
Title: USEFUL PHARMACEUTICAL SALTS OF 7-[(3R,4R)-3-HYDROXY-4-HYDROXYMETHYLPYRROLIDIN-1-YLMETHYL]-3,5-DIHYDROPYRROLO[3,2-d]PYRIMIDIN-4-ONE
Inventor: BARTLEY GARY
IPC: C07D487/04
Filed: 2010-03-24
Abstract: The present disclosure provides novel hemi-salts of 7-[(3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidin-1-ylmethyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one (compound 1) with Corganic diacids. The present invention further provides novel methods for preparing these salts. The novel monohydrates hemi-salts of the Corganic diacids are isostructural and can be prepared with different properties. Multiple acids can be used simultaneously and the proportion of acids can be varied offering the opportunity to select hemi-salts of compound 1 with desired properties.
Patent EA-022661-B1 (EA)
Title: Hydrocarbon gas processing
Inventor: JOHNKE ANDREW F
IPC: F25J3/00
Filed: 2010-05-03
Abstract: A process and an apparatus are disclosed for the recovery of ethane, ethylene, propane, propylene, and heavier hydrocarbon components from a hydrocarbon gas stream in a compact processing assembly. The gas stream is cooled and divided into first and second streams. The first stream is further cooled to condense substantially all of it and is thereafter expanded to lower pressure and heated to form a vapor fraction and a liquid fraction. The liquid fraction is supplied as a first top feed to an absorbing means inside the processing assembly. The second stream is also expanded to lower pressure and supplied as the bottom feed to the absorbing means; a first distillation vapor stream is collected from the upper region of the absorbing means and combined with the vapor fraction to form a combined vapor stream.
Patent EA-023218-B1 (EA)
Title: Replaceable wear part device with a holder provided for attachment to at least a portion of a work tool arranged to be able to move uncompacted material
Inventor: SKJAEVELAND MAGNE
IPC: E02F9/28
Filed: 2010-12-15
Abstract: There is described a replaceable wear part device (22) with a holder (21) provided for attachment to at least a portion of a work tool (1), arraged to be able to move uncompacted material, the wear part (22) is provided with a first sliding surface (222), wherein the wear part holder (21) is provided with a second sliding surface (213), which essentially is arranged as an extension of the first sliding surface (222), and the second sliding surface (213) is provided with a forward sliding edge surface (214) defining the sliding surface (213) against the wear part (22), where on the first sliding surface (222) an eminence (224) is provided arranged to be able to lead a material flow (F) away from at least a portion of the second sliding surface (213) of the wear part holder (21).
Patent EA-020652-B1 (EA)
Title: Diphenyl-pyrazolopyridine derivatives, preparation thereof, and use thereof as nuclear receptor not modulators
Inventor: AUGER FLORIAN
IPC: A61P25/08
Filed: 2010-12-03
Abstract: The invention relates to formula (I)in which R is a hydrogen or halogen atom or a (C-C)alkyl group; X is one or more substituents selected from a hydrogen or halogen atom, a (C-C)alkyl, halo(C-C)alkyl, (C-C)alkoxy, halo(C-C)alkoxy, cyano, hydroxy, or hydroxy(C-C)alkyl group; Y is a hydrogen or halogen atom or a (C-C)alkyl group; R1 is an NR2R3 or OR4 group; R2 and R3 independently are a hydrogen atom, a (C-C)alkyl, hydroxy(C-C)alkyl or oxo(C-C)alkyl group, or R2 and R3, together with the nitrogen atom supporting the same, form a heterocycle optionally substituted by a (C-C)alkyl, hydroxy, or oxo group; R4 is a (C-C)alkyl, hydroxy(C-C)alkyl, or oxo(C-C)alkyl group, in the base or acid addition salt state. Said formula can be used therapeutically for treating or preventing diseases linked to the nuclear receptors Nurr-1, also known as NR4A2, NOT, TINUR, RNR-1, and HZF3.
Patent EA-021531-B1 (EA)
Title: Animal tag applicator
Inventor: BLADEN ROY VICTOR
IPC: A01K11/00
Filed: 2011-01-26
Abstract: Provided applicator (1) for applying a tag on an animal's ear has handles (2, 4) which on closing together will engage an animal tag with the animal's ear but at which time a control member (28) will engage with a linkage (6) to trip the linkage (6) into a jaw-open position. Once the handles (2, 4) have been released the linkage (6) will again be returned to its normal position primarily under the bias of a spring (25).
Patent EA-026887-B1 (EA)
Title: Transparent pane with electrically conductive coating and method for producing said pane
Inventor: SCHMITZ CHRISTOPH
IPC: H05B3/86
Filed: 2012-10-04
Abstract: The present invention relates to a transparent pane with an electrically conductive coating and to a method for producing said pane. The transparent pane comprises at least one transparent substrate (1) and at least one electrically conductive coating (2) on at least one surface of the transparent substrate (1), wherein the electrically conductive coating (2) comprises at least two functional layers (3) which are arranged one above the other, and each functional layer (3) comprises at least one optically highly refractive material layer (4) which has a refractive index greater than or equal to 2.1, a smoothing layer (5) which is above the optically highly refractive material layer (4), said smoothing layer containing at least one non-crystalline oxide, a first matching layer (6) which is above the smoothing layer (5), an electrically conductive layer (7) which is above the first matching layer (6), and a second matching layer (8) which is above the electrically conductive layer (7); the total thickness of all the electrically conductive layers (7) is between 40 to 7 nm; and the electrically conductive coating (2) has a low ohm/square sheet resistance, and the optically highly refractive material layer (4) contains at least one mixed silicon/metal nitride.
Patent EA-037180-B1 (EA)
Title: Container blank
Inventor: SKINNER LESLIE JOHN
IPC: B65D5/36
Filed: 2014-10-24
Abstract: A container (10) consists of a substantially planar blank having a plurality of regions, the regions including a base (18), side walls (14), end walls (16) and a lid (12). Each of the regions is connectable to at least one of the other regions by a hinge (20) formed within the blank. The blank is able to be converted into a first unassembled configuration in which regions of the blank are pivoted around the hinges (20) connecting the regions in relation to other regions, to form a rectangular slab in which compact mode blanks are able to be stacked, and a second configuration in which the blank is erected to form the container (10), which has a cuboidal structure of substantially uniform cross-section, for the storage of articles. The hinge (20) comprises a recess (32) the recess (32) defining a point (30) of minimum cross section, said point (30) forming the pivot point (30) about which pivotal movement of adjacent regions occurs, wherein opposing side walls (33, 35) of the recess (32) are configured to interengage when one of the regions is pivotally moved through a 90° arc relative to an adjacent region, said interengagement comprising meshing of at least one stepped region (34) of a side wall (35) with a surface of the opposing side wall (33). The base (58) of a container (50) may also include ledge portions (60) at each of the corners of the base (58), which ledge portions (60) provide support for hinges (70) when the container is in the cuboidal configuration.
Patent EA-034017-B1 (EA)
Title: Methods based on cultivating bacillus coagulans mtcc 5856 in the presence of natural plant fibers
Inventor: MAJEED MUHAMMED
IPC: A61K35/742
Filed: 2015-08-29
Abstract: The present invention relates to a method of increasing the viable colony count of Bacillus coagulans MTCC 5856, said method comprising the step of cultivating Bacillus coagulans MTCC 5856 in the presence of natural plant fibers selected from Trigonella foenum-graecum (fenugreek) seed fibers, Lycium barbaram seed fibers, Linum usitatissimum (Flax) seed fibers, Cocos nucifera (Coconut) fibers, Zingiber officinale (Ginger) rhizome fibers, Emblica officinalis (Amla) fruit fibers, Plantago ovata (Psyllium) fibers and Vaccinium oxycoccos (Cranberry) seed fibers. The method provides an effective growth stimulation of probiotic bacteria Bacillus coagulans MTCC 5856. Furthermore, provided are a method of inhibiting E. coli and a method of producing short chain fatty acids, wherein the above mentiond combination of natural plant fibers and Bacillus coagulans MTCC 5856 is used.
Patent EA-037327-B1 (EA)
Title: Compounds and compositions for the treatment of ocular disorders
Inventor: CLELAND JEFFREY L
IPC: A61K47/34
Filed: 2016-09-22
Abstract: Described are compounds characterized by structural formulas (XIV) and (XV), as well as pharmaceutical compositions comprising such compounds and the use of the compounds in treating ocular disorders treatable with a tyrosine kinase inhibitor.
Patent EA-039639-B1 (EA)
Title: Process for the extraction and purification of hyaluronic acid
Inventor: CORSA VINCENZA
Filed: 2018-07-17
Abstract: The invention therefore relates to the field concerning processes for the extraction and purification of hyaluronic acid from fermentation broth, the processes providing the following steps: a. dilution of the filtered fermentation broth with purified water; b. forced recirculation of the broth coming from step a. formed by the joining of retentate and permeate inside tangential flow filter (TFF) cassettes containing ultrafiltration membranes, wherein the forced recirculation is repeated for a time ranging from 1 to 6 h, said recirculation being conducted with a unidirectional flow and in a closed system, at a constant volume without introducing liquids from the outside. Using said steps makes the overall processes industrially more convenient, thus leading to a net saving both in terms of processing times, the use of materials and waste to be disposed of. The processes of the invention surprisingly increase the process yield in its entirety, allowing a much greater improvement in their efficiency.
Patent ES-2264285-B1 (ES)
Title: Metodo de fabricacion de sandalias y molde para aplicacion del mismo.
Inventor: MARTINEZ GIMENEZ ALBERTO
IPC: A43B3/12
Filed: 2001-10-24
Granted: 2007-12-01
Abstract: El molde está constituido a partir de un cuerpo base (1) dotado de un rehundido (6) formal y dimensionalmente coincidente con el piso propiamente dicho (7) de la sandalia, de caucho o similar, destinado a acoplarse en su seno, piso (7) al que se adapta superiormente y en posición adecuada la tira (11) constitutiva del corte de la sandalia, que queda a su vez perfectamente encajada en rebajes (10-10'') de la cara inferior del anillo intermedio (2) del molde, en situación de cierre para este último, de manera que en el seno de dicho anillo intermedio se establece una cámara (8) cerrada inferiormente por la tira (11) y por el piso propiamente dicho (7) y cerrada superiormente por la tapa o contramolde (3), a la que previamente se habrá adaptado el melope (14), que queda fijado entre la tapa (3) y el anillo intermedio (2), rellenándose la citada cámara en fase de moldeo con el material constitutivo de la planta, como por ejemplo corcho o similar, de manera que en el propio moldeo de dicha planta, ésta actúa como nexo de unión para el resto de los componentes de la sandalia.
Patent ES-2197791-B1 (ES)
Title: Procedimiento y dispositivo de mando para el control de un vehiculo equipado con una caja de cambios manual.
Inventor: VORNEHM MARTIN
IPC: B60W10/10
Filed: 1999-11-12
Granted: 2005-03-01
Abstract: Procedimiento y dispositivo para el control de un vehículo equipado con una caja de cambios manual el cual dispone de un embrague, una caja de cambios manual y un motor. Con este procedimiento se comprueba la aceleración (1) del vehículo por medio de un dispositivo de mando y, antes de una maniobra de cambio de marcha, se reduce a un primer valor de aceleración (3). Después de transcurrido un tiempo prefijado, el valor de aceleración se reduce a un segundo valor, que es más bajo que el primer valor.
Patent ES-2190765-B1 (ES)
Title: Procedimiento y aparato para la clasificacion de tapones de corcho.
Inventor: BARTROLI FERRARONS JORDI
IPC: G01B11/30
Filed: 2002-01-22
Granted: 2004-06-01
Abstract: Procedimiento y aparato para clasificación de tapones de corcho. El procedimiento se caracteriza por proceder a la iluminación de la superficie lateral del tapón de corcho mediante una fuente de luz que se combina con la formación de una línea de sombra sobre una parte de la superficie lateral del tapón de corcho, procediendo simultáneamente a la toma de imágenes mediante una cámara matricial dispuesta según un ángulo predeterminado con respecto a la fuente de luz, determinando en la superficie lateral del tapón una primera zona que contiene la línea de sombra y una segunda zona inmediata de saturación de luz, permitiendo la primera la detección de los orificios y la valoración de su profundidad, y la segunda, debido a la saturación de iluminación, permite la detección de los orificios con supresión o notable reducción de la imagen de las manchas.