Patent SG-11201900343P-A (SG)
Title: Sulfonamides as gpr40- and gpr120-agonists
Inventor: DE PIZZOL MARIA
IPC: C07D285/135
Filed: 2017-08-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111 0111011110111111111111111010111H1111011011110111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/029150 Al 15 February 2018 (15.02.2018) WIP0 I PCT (51) International Patent Classification: Chiara Rossana Maria; viale Caprilli, 23,1-20148 Milano C07D 231/42 (2006.01) C07D 285/04 (2006.01) (IT). C07C 311/16 (2006.01) C07D 285/135 (2006.01) C07C 311/21 (2006.01) C07D 263/50 (2006.01) (74) Agent: VIGANO, Elena et al.; Via Nino Bixio, 7, 0129 Milano MI (IT). C07C 311/51 (2006.01) A61P 3/00 (2006.01) C07D 235/30 (2006.01) A61K 31/18 (2006.01) (81) Designated States (unless otherwise indicated, for every C07D 249/04 (2006.01) A61K 31/415 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 249/08 (2006.01) A61K 31/42 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CO7D 249/14 (2006.01) A61K 31/425 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, CO7D 257/06 (2006.01) A61K 31/433 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, CO7D 261/16 (2006.01) A61K 31/41 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, CO7D 263/30 (2006.01) A61K 31/4184 (2006.01) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, CO7D 275/03 (2006.01) A61K 31/4192 (2006.01) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, CO7D 277/52 (2006.01) A61K 31/4196 (2006.01) OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (21) International Application Number: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, PCT/EP2017/069958 TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 07 August 2017 (07.08.2017) kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (25) Filing Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (26) Publication Language: English = EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (30) Priority Data: = 16183294.4 09 August 2016 EP TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (09.08.2016) — KM, ML, MR, NE, SN, TD, TG). (71) Applicant: DOMPE' FARMACEUTICI S.P.A. [IT/IT]; = = Via S. Martino della Battaglia, 12, 1-20122 Milano (MI) = Declarations under Rule 4.17: — (IT). inventorship (Rule 4.17(iv)) — of Inventors: DE PIZZOL, Maria; Dompe Farmaceuti- (72) c/o Published: ci S.p.A., Via Santa Lucia, 6, 1-20122 Milano (IT). SIRI- — — Anna; Dompe Farmaceutici Pietro with international search report (Art. 21(3)) CO, c/o S.p.A., Via = Castellino, 111, 1-80131 Napoli (IT). ZIPPOLI, Mara; c/ = o Dompe Farmaceutici S.p.A., Via Pietro Castellino, 111, = 1-80131 Napoli (IT). BIANCHINI, Gianluca; c/o Dom- _ Farmaceutici di Pile 1-67100 = pe S.p.A., Via Campo s.n.c., L'Aquila BECCARI, Andrea; Dompe Farmaceu- (IT). c/o tici S.p.A., Via Campo di Pile, s.n.c., 1-67100 L'Aquila (IT). ARAMINI, Andrea; c/o Dompe Farmaceutici S.p.A., Via = Campo di Pile s.n.c., 1-67100 L'Aquila (IT). LIBERATI, = = = = (54) Title: SULFONAMIDES AS GPR40- AND GPR120-AGONISTS R1 Ra 1-1 ____ A (X) n NH—s(o) 2 0 kin ,—, tz. 2 R N(I) © .-- - 6, t) (57) : The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), Il and having formula (I). Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GPR40 such as diabetes (particularly type 2 diabetes), impaired oral glucose tolerance, insulin resistance, obesity, obesity related disorders, ei metabolic syndrome, dyslipidemia, elevated LDL, elevated triglycerides, obesity induced inflammation, osteoporosis and obesity related O cardiovascular disorders.