baber/WOPTO huggingface dataset:
Patent CZ-53998-A3 (CZ)
Title: Sulfonamide substituted annellated compounds with seven-membered ring, their use and pharmaceutical compositions containing thereof
Inventor: BRENDEL JOACHIM DR
IPC: A61K31/39
Filed: 1998-02-24
Abstract: Benzoxepine and benzocycloheptane derivatives of formula (I), their stereoisomers and salts are new. X1 = O, S, SO, SO2, CR1R2, NR6, CO or CR1R7; R1, R2 = H, CF3, C2F5, C3F7, 1-6C alkyl or phenyl (optionally substituted by 1 or 2 of halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me; or R1+R2 = 2-10C alkylene; R6 = H or CnH2nR8 (with one CH2 group optionally replaced by O, CH=CH, C  IDENTICAL  C, CO, COO, OCO, S, SO, SO2, NR9 or CONR9; R9 = H or 1-4C alkyl; n = 0-8; R8 = H, CF3, C2F5, C3F7, 3-8C cycloalkyl, NMe2, NEt2, piperidino, pyrrolidino, morpholino, 4-methyl-1-piperazinyl or pyridyl, thienyl, imidazolyl or phenyl (all optionally substituted by 1 or 2 halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); X2 = CR1R2 or CR2R10; or X2 = O, S, SO, SO2 or NR6 if X3 and X1 are CR1R2; R10+R7 = bond; X3 = CR1R2; or X3 = O, S, SO, SO2 or NR6 if X2 and X4 are CR1R2; X4 = CR1R2, NR6, NR11, CH(OR30) or CR2R11; R30 = H, 1-3C alkyl or 1-4C acyl; R11+R5 = bond; Y1-Y4 = CR12 or N with no more than two being N; R12 = H, halo, 1-5C alkyl, 3-8C cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2, ZCmH2mR13 or phenyl (optionally substituted by 1 or 2 halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); Z = O, CO, COO, OCO, S, SO, SO2, SO2NR14, NR14 or CONR14; R14 = H or 1-3C alkyl; m = 0-6; R13 = H, CF3, C2F5, C3F7, 3-8C cycloalkyl, NR15R16, CONR15R16, OR30a or phenyl, thienyl or 1-9C N-containing heterocyclyl (all optionally substituted by 1 or 2 halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); R15, R16 = H or 1-3C alkyl; or R15+R16 = 4-5C methylene (with one carbon optionally replaced by O, S, NH, NMe or N(benzyl)); R30a = H, 1-3C alkyl or 1-4C acyl; or Y1+Y2 = S and Y3, Y4 = CR12; R3 = NR18CxH2xR17 or CxH2xR17 (with one CH2 group optionally replaced by O, CO, S, SO, SO2 or NR19); R19 = H, Me or Et; R17 = H, Me, 3-8C cycloalkyl, CF3, C2F5 or C3F7; x = 0-10; R18 = H or 1-8C alkyl; or R18+R17 = bond if x = 3-10; or R3 = phenyl (optionally substituted by 1 or 2 halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); or R3+R4 = 3-8C alkylene (with one CH2 optionally replaced by O, CO, S, SO or SO2); R4 = CrH2rR20 (with one CH2 group optionally replaced by O, CH=CH, C  IDENTICAL  C, CO, COO, OCO, S, SO, SO2, NR21 or CONR21); R21 = H or 1-3C alkyl; r = 0-20; R20 = H, CF3, C2F5, C3F7, 3-8C cycloalkyl, NR22R23 or phenyl, thienyl or 1-9C N-containing heterocyclyl (all optionally substituted by 1 or 2 halo, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); R22, R23 = H or 1-3C alkyl; or R22+R23 = 4-5C methylene (with one carbon optionally replaced by O, S, NH, NMe or N(benzyl)); and R5 = H; or R5+R11 = bond.
Patent SK-26793-A3 (SK)
Inventor: SECKAR PAVOL
IPC: G01N3/16
Filed: 1993-03-30
Abstract: Z deformácie pružiny (16) spojenej s unášanou upínacou
hlavou (17) sa cez ozubenú tyč (15) a prevodový silomerný
mechanizmus prenáša výchylka sily na zapisovač (11)
a deformácia skúšobnej vzorky (2) spôsobuje cez prevodový
deformačný mechanizmus (5) posuv papiera (8), čím
sa zaznamená pracovný diagram.
Patent SK-31895-A3 (SK)
Title: Method and circuit for charging batteries
Inventor: ETTEL VICTOR ALEXANDER
IPC: H02J7/10
Filed: 1993-07-14
Abstract: A battery charge is provided which automatically controls the charging process independent of individual battery construction or temperature. Control of the charging process is achieved by periodically interrupting the charging current, determining resistance-free voltage of the battery in fixed intervals after interruptions of current, and comparing the resistance-free voltage with a reference voltage. Reference voltage is automatically determined for each recharging subject by analyzing the change in resistance-free voltage with respect to time during an initial, constant current period to locate certain characteristic points indicative of the onset of overcharge. The charging current is reduced as necessary, so that the resistance-free voltage does not exceed the reference voltage and significant overcharge is avoided.
Patent SK-38595-A3 (SK)
Title: Manufacturing process for transdermal therapeutic systems
Inventor: HILLE THOMAS
IPC: B32B37/22
Filed: 1993-09-15
Abstract: PCT No. PCT/EP93/02495 Sec. 371 Date May 9, 1995 Sec. 102(e) Date May 9, 1995 PCT Filed Sep. 15, 1993 PCT Pub. No. WO94/07449 PCT Pub. Date Apr. 14, 1994The invention provides a process for the production of transdermal therapeutic systems. A layer containing active substance is initially present as a tape or web in the form of a laminate, with a carrier layer and, possibly, further auxiliary layers and/or protective layers or the like. The active substance is then transferred from this layer, either by itself or in combination with at least one further layer, in sections, to the center of a second, wider web. The process is characterized by the fact that the tape or web (1) and the second web (2) are moved forward by steps, with different phases of motion and inoperative phases and/or different step lengths and/or differing speeds and that in the same appliance, during each inoperative or stationary phase of the webs (1, 2) the subdivision of the layer containing active substance and, as the case may be, of one or more further layers, with the exception of the carrier layer, takes place in phases and in the same forward direction, at right angles to the direction of web, into sections (7, 8) containing active substance of a size suitable for the user, and their transfer to the second web, the carrier sheet (9) being removed, in preferably equal intervals, using a transfer device which can be moved backwards and forwards in the direction of the web.
Patent SK-64397-A3 (SK)
Title: Method of production of a siliceous refractory mass and a refractory brick made according to this method
Inventor: MEYNCKENS JEAN-PIERRE
IPC: C04B35/65
Filed: 1995-11-23
Abstract: A process is provided producing a crystalline siliceous refractory mass by projecting solid refractory particles, solid silicon particles and gaseous oxygen against a surface in such a way that reaction between the silicon particles and gaseous oxygen occurs against the surface, thereby releasing the heat of reaction against the surface so that a coherent refractory mass comprising cristobalite is formed, wherein the solid refractory particles comprise silica in the form of vitreous silica and in that the surface against which they are projected is at a temperature of a least 1000 DEG C. The process can be used for in situ repair of high temperature furnaces such as glassmaking furnaces or for the manufacture of high quality refractory bricks.
Patent SK-72016-A3 (SK)
Inventor: VIRGALA IVAN
IPC: F16L55/26
Filed: 2016-02-01
Abstract: Kolesový potrubný stroj s automatickým nastavením rozpätia kolies podľa priemeru potrubia je určený na pohyb v potrubí (22). Vynález obsahuje hlavné teleso stroja (1) a upevňovacie teleso (2), medzi ktorými sú vodiace tyče (3) so šmýkadlom s pohybovou maticou (4) a vodiacou skrutkou (5) uloženou medzi vodiacimi tyčami (3). Vodiaca skrutka (5) je pripojená k servopohonu vodiacej skrutky (11), ktorým je vytvorený priamočiary pohyb šmýkadla s pohybovou maticou (4) po vodiacej skrutke (5) a vodiacich tyčiach (3). Na vodiacich tyčiach (3) je pri šmýkadle s pohybovou maticou (4) uložený aj unášač hnacích kolies (7) s pružinou vodiacej skrutky (10). Na pomocných vodiacich tyčiach (8) upevnených k šmýkadlu s pohybovou maticou (4) je uložený unášač voľnobežných kolies (6) s pružinami (9). K unášačom (6) a (7) a hlavnému telesu (1) sú rovnomerne po obvode vynálezu pripevnené tri mechanizmy s hnacími kolesami (16) a voľnobežnými kolesami (17).
Patent SK-76296-A3 (SK)
Title: Open steel cord structure, method of manufacture thereof and device for carrying out this method
Inventor: VAN GIEL FRANS
IPC: D07B1/06
Filed: 1994-12-09
Abstract: A steel cord (114) comprises strength elements (100, 132) and having a length, a longitudinal central axis (112) and a cord pitch. At least one of the elements (100) has a projection on a plane YZ perpendicular to the longitudinal central axis (112). This projection takes the form of a curve with a radius of curvature which alternates between a maximum and a minimum. The curve further has a center of curvature. The radius of curvature and the center of curvature lie inside the curve so that a convex curve is obtained. The cord (114) is further characterized by one or both of following features: (i) the distance between two minimum radii of curvature of said curve measured along the longitudinal central axis (112) is different from half the cord pitch; or (ii) if all of said elements (100) provide a convex curve, at least one of said convex curves substantially differs from another convex curve.
Patent SK-96398-A3 (SK)
Title: Exodus chemokine materials and methods
Inventor: HROMAS ROBERT
IPC: C07K16/24
Filed: 1997-11-14
Abstract: The present invention provides purified and isolated polynucleotide sequences encoding a human macrophage-derived C-C chemokine designated Exodus. Also provided are purified and isolated chemokine protein, fragments and polypeptide analogs thereof, antibodies thereto, and materials and methods for the recombinant production thereof. These products are useful in therapeutic, diagnostic and medical imaging applications.
Patent CH-649433G-A3 (CH)
IPC: G04B19/253
Filed: 1983-08-30
Abstract: The perpetual calendar mechanism of the invention comprises in addition to the months indicator a four year cycle indicator which displays successively the normal years and the leap-year. The four year cycle indicator is controlled directly or indirectly by a rotatable assembly journalled on the month star such assembly including a year cam and a Maltese cross enabling it to effect one revolution every four years. In one variant illustrated the mechanism includes a first ring bearing the year indications and a second ring concentric to the first ring bearing an index marker. At each year change the index marker is shifted a quarter turn relative to the indications borne by the first ring.
Patent CZ-208292-A3 (CZ)
Title: Composition from vinyl monomer with accelerated surface cure
Inventor: HINZ FREDERICK PAUL
IPC: C08F279/00
Filed: 1992-07-02
Abstract: Vinyl monomer compositions having accelerated surface cure characteristics are described. These compositions are prepared from a vinyl monomer or monomer mixtures such as blend of isobornyl methacrylate and hydroxypropyl methacrylate, a bulk phase polymerization catalyst system, a polyvalent metal oxidative surface phase catalyst, and a diolefin rubber dispersed in the vinyl monomer as a surface cure accelerator. These compositions are useful as sealers, healers and for polymer concrete.
Patent CZ-224992-A3 (CZ)
Inventor: PESIK LUBOMIR DOC ING CSC
IPC: B62B5/06
Filed: 1992-07-20
Abstract: K držadlu (15), spojenému s rámem stroje, je připojena
dvojramenná vidlice (3), jejíž konce jsou spojeny vodící
tyčí (6), na níž je suvné uložena objímka (4). Objímka (4)je
opatřena alespoň jednou pružící jednotkou (5). K držadlu
(15) je otočně připojen jedním koncem nosník (1), který je
zároveň otočně připojen k objímce (4). Druhý konec nosníku
(1) je připojen k rukojeti (16), opatřené uchopovacími
madly (10).
Patent CZ-230890-A3 (CZ)
Title: Process for preparing vanadium arenes
Inventor: CALDERAZZO FAUSTO
IPC: C08F10/00
Filed: 1990-05-10
Abstract: Vanadium-arenes [V(arene)2] (arene = benzene or mono-, di-, or poly-alkyl-substituted benzene) are obtained, with a high yield, by means of the reduction of a vanadium-arene iodide with zinc, manganese or iron in metal form, or with cobalt di-(cyclopentadienyl). Vanadium-arenes are useful in the preparation of catalyst components active in ethylene polymerization, or in the copolymerization of ethylene in an alpha-olefin.
Patent CZ-251892-A3 (CZ)
Title: Methanoanthracene derivatives, process of their preparation and pharmaceutical compositions in which said derivatives are comprised
Inventor: JACOBS ROBERT TOMS
IPC: C07D211/32
Filed: 1992-08-14
Abstract: Compounds of formula I, and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychisatric disoders such as psychoses; pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable diluent or carrier; and methods of treating neuropschiatric disorders comprising administering to a mammal (including man) in need of such treatment an effective amount of a compound of formula I, or a pharmaceutically acceptable salts thereof. <IMAGE>
Patent CS-9002857-A3 (CS)
Title: Process for preparing purified albumin from human or animal physiological salt solution
Inventor: DERNIS DOMINIQUE
IPC: A61K38/38
Filed: 1990-06-08
Abstract: The invention relates to a process for the preparation of purified albumin from a human or animal physiological solution such as a plasma or plasma fraction. The process comprises a treatment of delipidation with an anionic detergent and two steps of separation by chromatography on ion exchange resin. Implementation of the process of the invention enables a stable, highly pure albumin solution for therapeutic application to be obtained.
Patent CS-395391-A3 (CS)
Title: Homogeneous human interleukin 2, process of its preparation and apharmaceutical composition based thereon
Inventor: STERN ALVIN S
IPC: A61K35/12
Filed: 1991-12-20
Abstract: Human interleukin 2 (IL-2) derived from induced human malignant cells has been purified to homogeneity using multiple high performance liquid chromatography (HPLC) steps. The purified IL-2 exhibits potent activity promoting the long-term in vitro culture of antigen-specific effector T-lymphocytes and in modulating lymphocyte reactivity.
Patent CZ-102995-A3 (CZ)
Title: Upper section of elevator well
Inventor: HITZ PETER
IPC: B66B11/00
Filed: 1995-04-21
Abstract: The shaft head has roller equipment (15) arranged on the shaft head that comprises a roller beam (14) and a roller bearer (16) with at least one rope roller (17). The roller beam is connected with the shaft head. The shaft head has a shaft head member (3) which has components (6, 11, 12, 13) for suspension of the roller equipment via a cover plate (5) which closes the lift shaft upwards. The shaft head component has a t least one load island (6) comprising anchors (7, 8) and a reinforcement basket for load accommodation. The reinforcement basket has reinforcement members which conduct the force exerted on the anchors into the pressure zone of the cover plate of the shaft head member. <IMAGE>
Patent CZ-107097-A3 (CZ)
Title: Adapter for exhaust conduit of a heating equipment and a building-block system for leading thereof through a roof
Inventor: BORN MARCEL MARTINE LEONARDUS
IPC: F23J13/02
Filed: 1997-04-08
Abstract: The attachment (12,28,60) collects water that has condensed on its lid (26) or sides (34) in a condensate trap (32), which is electrically heated or thermally coupled to the exhaust flue outlet (22). The attachment base (46) is thermally conductive, e.g. made of aluminium. It is fastened (88,90) to the flue outlet, and has a heating element (30), a temperature sensor, and a heat transfer surface (44). The condensate trap is inclined to drain either outwards or inwards into the exhaust flue. The lid (26) is conical so that condensate (64) drips either from its centre into the flue, or from its outer edge into the condensate trap. Several alternative flue arrangements are described.
Patent CZ-110996-A3 (CZ)
Title: Screened connector system
Inventor: GREEN MARTIN
IPC: H01R13/506
Filed: 1995-04-27
Abstract: A shielded connector assembly having a snap locking mounting scheme. The assembly includes a panel yoke (2) with snap locking elements (21) for snap lockingly, removably securing the panel yoke in a panel or cover plate. The panel yoke is also constructed to snap lockingly engage a shielding device (30) which in turn is constructed to snap lockingly engage a connector assembly comprising an interconnecting device (61) which may be a printed circuit board (59) including integrally defined reactive elements (85) designed to compensate for reactive imbalance of electrical components connected thereto. A pair of wire termination blocks (70) mounted to a first side of the circuit board are connected by circuitry on the circuit board to a corresponding modular jack (60) mounted on a second side of the circuit board. The reactive elements produce an impedance between selected leads of the modular jack and the wire termination blocks by the circuitry. A snap locking combination of the shield device and a shielding cover (90) completely shield the connector assembly.
Patent CZ-157499-A3 (CZ)
Title: (4s, 5s, 6s, 7r)-hexahydro-1-[5-(3-aminoindazole)methyl]-3-butyl-5,6-dihydroxy-4,7-bis [phenylmethyl]-2h-1,3-diazepin-2-one, process of its preparation and its use as hiv proteinase inhibitor
Inventor: RODGERS JAMES DAVID
IPC: C07D403/06
Filed: 1997-11-04
Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salt forms or prodrugs thereof, which are useful as inhibitors of HIV protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
Patent CZ-175797-A3 (CZ)
Title: Breath refreshing eatable compositions containing menthol and n-substituted p-menthanecarboxamide and process for preparing such compositions
Inventor: LUO SHIUH JOHNSON
IPC: A23G4/06
Filed: 1995-11-09
Abstract: The present invention is directed at chewing gum compositions having long-lasting breath freshening perception without bitterness comprising (a) a gum base; (b) a bulking agent; and (c) a cooling composition; wherein the cooling composition comprises menthol and an N-substituted-p-menthane carboxamide, wherein the carboxamide may be represented by formula (1), wherein R1 and R2 may be independently selected from the group consisting of hydrogen and an alkyl group containing from 1 to 25 carbon atoms, with the proviso that when R1 is hydrogen, R2 may be an aryl group containing from 6 to 10 carbon atoms and, R1 and R2 when taken together, may be a cyclic or heterocyclic group containing up to 25 carbon atoms; and wherein the N-substituted-p-menthane carboxamide is present in the cooling composition in an amount from about 0.001 % to about 6 %, and menthol is present in the cooling composition in an amount from about 94 % to about 99.999 %. The present invention is also directed at confectionery compositions containing the novel cooling composition and methods for preparing the novel chewing gum and confectionery compositions.
Patent CZ-182998-A3 (CZ)
Title: Catalytic converter
Inventor: NILSSON SVEN MELKER
IPC: B01J35/04
Filed: 1995-12-13
Abstract: The invention concerns improvements in catalytic converters for optimising the ratio of pressure drop to mass transfer of gases flowing through the catalytic converter. For this purpose, the latter is provided with channels (1) formed with turbulence generators (3, 4) extending transversely in the path of flow of the gases. In order to obtain this object, the structure of the catalytic converter should satisfy certain distinct conditions. These conditions refer to the distance from the catalytic converter inlet (1) to the center of the turbulence generator (3) positioned closest to said inlet, the angle defining the inclination of the trailing edge face (5) of the turbulent generators (3, 4) relatively to a vertical plane through the bottom (8) of the catalytic converter channel (2), the ratio of the height of the upper face (6) above the bottom (8) to the hydraulic diameter of the channel (2), the ratio of the distance between the centers of the first (3) and the second turbulence generators (4), as seen from the inlet (1), to said height, and the ratio of the length of the upper face (6) of each turbulence generator (3, 4) to the height of said face above the catalytic converter bottom (8).
Patent CZ-200022-A3 (CZ)
Inventor: BACHLE DIETER
IPC: B60H1/22
Filed: 2000-01-05
Abstract: U ovládacího zařízení pro ovládání topidlamotorového
vozidla v podobě přitápěcího nebo parkovacího topidla se
navrhuje komponenty topidla, které májak přitápěcí, tak také
parkovací topidlo, ovládatspolečnou základní elektronickou
(2), zatímco pro parkovací topidlo typické komponenty
vozidla, které nemá přitápěcí topidlo, zejména vodní čerpadlo
(WP) a vozidlové dmýchadlo (GB),jsou ovládány oddělenou
přídavnou elektronikou (1), kteráje uspořádána na externím
místě, s výhodou v obslužnémústrojí topidla, účelně ve
spínacích hodinách nebo radiovémpřijímači. Přídavná
elektronika (1)je se základní elektronikou (2) spojena přes
dvousměrový spoj. Prostřednictvímpřídavné elektroniky (1)
lze přeměnit přitápěcí topidlo snadno na parkovací topidlo a
opačně.
Patent CZ-200891-A3 (CZ)
Inventor: BAK TOMASZ
IPC: A01N59/20
Filed: 2008-02-20
Abstract: Prípravek k hubení mechu a lišejníku, sestává z 1 až 5 % hmotn. mednaté nebo medné ve vode nerozpustné slouceniny a 95 až 99 % hmotn. vody. Prípravek k hubení mechu a lišejníku obsahuje látku zabranující sedimentaci behem aplikace prípravku. Prípravek k hubení mechu a lišejníku dále obsahuje látku zvyšující prilnavost k podkladu. Zpusob výroby prípravku k hubení mechu a lišejníku spocívá v tom, že roztok síranu mednatého se primíchává do vodného roztoku boraxu nebo látky tvorící se síranem mednatým ve vode nerozpustnou sraženinu v takovém množství až smes vykazuje neutrální reakci, tedy hodnota pH = 7.
Patent CZ-9702013-A3 (CZ)
Title: Method for controlling access to recording disk and apparatus for making the same
Inventor: TOTSUKA TAKASHI
IPC: G06F3/06
Filed: 1996-10-24
Abstract: A method and apparatus for controlling access to a recording disk which determines a skew so that a rotational delay time at an average distance of movement when a head accesses the recording disk is minimized. The methods and apparatus determine the position of a data block on the recording disk based on at least the determined skew, schedules an order of a plurality of input disk access requests so that an amount of movement of the head becomes small at the time of access with respect to the recording disk by the head, and the head accesses the recording disk based on the result of the scheduling.
Patent CZ-210996-A3 (CZ)
Inventor: PERSIN JAN ING
IPC: C07D201/04
Filed: 1996-07-17
Abstract: Řešení se týká způsobu zapojení stanice rektifikace
kaprolaktamu, přičemž oddělování
hlavní frakce je řešeno dvojstupňové. Mezi
stupně produkující hlavní frakci je vložena separace
těžkých podílů, která se provádí na
filmové rotorové odparce.
Patent CZ-226099-A3 (CZ)
Inventor: LI YAO-EN
IPC: B01D53/22
Filed: 1997-12-16
Abstract: Způsob spočívá v a/ odstranění anorganických fluoridů z odplynu
elektrolyzéru pro výrobu hliníku, obsahujícího anorganické
fluoridy a alespoňjeden z CF4 a Cy6, přičemž se získá vyčištěný
odplyn, ab/ uvedení vyčištěného odplynu do styku s membránou
při teplotě 10 až 80 °C, tlakovém spádu 0,02 až 1,4 MPa a
průtoku mezi 10"4 až 10 Nrrř/hm2, čímž se získá zadržený proud
plynu bohatý na alespoňjeden zCF4 a QFg a prošlý proud plynu,
zbavený alespoňjednoho zCF4 aC2F6.
Patent CZ-228399-A3 (CZ)
Title: Pesticidal 1-arylpyrazole compounds, method of their application and preparations in which they are comprised
Inventor: CHENE ALAIN
IPC: A01N43/56
Filed: 1997-12-18
Abstract: The invention relates to novel 1-arylpyrazole oxime derivatives, of general formula (I) or (I bis). These compounds are found to be generally safe systemic insecticides for control of arthropod, nematode, helminth or protozoan pests including compositions and derivatives thereof.