baber/WOPTO huggingface dataset:
Patent BR-112022011725-A2 (BR)
Title: Moduladores de kbtbd4 adaptadora de cullin 3 como compostos anticâncer
Inventor: GUY SAUVAGEAU
IPC: A61P35/00
Filed: 2020-12-18
Abstract: MODULADORES DE KBTBD4 ADAPTADORA DE CULLIN 3 COMO COMPOSTOS ANTICÂNCER. É fornecido o uso de derivados de pirimido[4,5-B]indol como compostos anticâncer, e mais especificamente o uso de UM171 e seus derivados para tratar câncer, por meio da ativação do complexo ubiquitina ligase CULLIN3-RING que degrada RCOR1 que normalmente atua como a proteína de andaime para o complexo RCOR1/LSD1 e HDAC2, sendo ele próprio dissociado na presença de UM171. Assim, UM171 atua como um degradador de cola molecular, inibindo HDACs, RCOR1, CoREST e LSD1 e resultando em uma atividade anticâncer.
Patent BR-112022013080-A2 (BR)
Title: Sistema de supervisão de solenoide
Inventor: TIMOTHY B DECKER
IPC: H01F7/18
Filed: 2020-12-31
Abstract: SISTEMA DE SUPERVISÃO DE SOLENOIDE. A presente invenção refere-se a sistemas e métodos para um sistema de detecção de supervisão de solenoide que pode detectar a presença ou ausência de um êmbolo de solenoide dentro de uma bobina de solenoide. Esses sistemas podem ser usados para verificar a remontagem correta de uma válvula solenoide após ela ter sido desmontada para teste.
Patent BR-112022013575-A2 (BR)
Title: Anticorpos conjugados com moléculas de ácido graxo e usos dos mesmos
Inventor: JACK CHONGYANG LI
IPC: A61K47/00
Filed: 2021-02-25
Abstract: ANTICORPOS CONJUGADOS COM MOLÉCULAS DE ÁCIDO GRAXO E USOS DOS MESMOS. A presente invenção refere-se a anticorpos monoclonais (mAbs) ou anticorpos biespecíficos (bsAbs) ou anticorpos multiespecíficos compreendendo uma molécula de ácido graxo (FA) conjugada com ou próximo ao domínio de ligação ao antígeno. Também são descritos ácidos nucleicos que codificam os anticorpos, composições que compreendem os anticorpos, e métodos para produzir os anticorpos e usar os anticorpos para tratar ou prevenir doenças, como câncer e/ou complicações associadas.
Patent BR-112022016941-A2 (BR)
Title: Compostos heterocíclicos para a modulação de nr2f6
Inventor: ROBERTO PELLICCIARI
IPC: C07D405/14
Filed: 2021-02-24
Abstract: COMPOSTOS HETEROCÍCLICOS PARA A MODULAÇÃO DE NR2F6. A presente invenção refere-se aos compostos capazes de modular a atividade de NR2F6. Os compostos da invenção podem ser usados em métodos para a prevenção e/ou tratamento de doenças e distúrbios associados com a modulação da atividade de NR2F6.
Patent BR-112022019559-A2 (BR)
Title: Sinalização de sintaxe trisoup para compressão de nuvem de pontos baseada em geometria
Inventor: BAPPADITYA RAY
IPC: G06T9/00
Filed: 2021-04-08
Abstract: SINALIZAÇÃO DE SINTAXE TRISOUP PARA COMPRESSÃO DE NUVEM DE PONTOS BASEADA EM GEOMETRIA. Um dispositivo de exemplo para processar dados de nuvem de pontos inclui uma memória configurada para armazenar os dados de nuvem de pontos e um ou mais processadores implementados no conjunto de circuitos e acoplado à memória. O um ou mais processadores são configurados para contar um número de bordas de um cubo de dados de nuvem de pontos compreendendo um vértice. O um ou mais processadores são configurados para definir uma variável com base em um total da contagem. O um ou mais processadores são configurados também para processar os dados de nuvem de pontos com base na variável.
Patent BR-112023001927-A2 (BR)
Title: Nós de rede e métodos nos mesmos para comunicação indireta
Inventor: YUNJIE LU
Filed: 2020-12-07
Abstract: NÓS DE REDE E MÉTODOS NOS MESMOS PARA COMUNICAÇÃO INDIRETA. A presente divulgação provê um método (100) em um nó de rede implementando uma função de Proxy de Comunicação de Serviço, SCP. O método (100) inclui: receber (110), a partir de uma primeira Função de Rede, NF, uma solicitação destinada a uma segunda NF, em que a solicitação compreende informações sobre a segunda NF; redirecionar (120) a solicitação para uma terceira NF, em que a solicitação redirecionada compreende informações sobre a terceira NF; e transmitir (130) uma resposta para a primeira NF, em que a resposta compreende as informações sobre a terceira NF.
Patent BR-112023002689-A2 (BR)
Title: Formulação de poliuretano, método para produzir um material de poliuretano, e, material de poliuretano
Inventor: PIETRO BUONO
IPC: C08G18/30
Filed: 2021-08-11
Abstract: FORMULAÇÃO DE POLIURETANO, MÉTODO PARA PRODUZIR UM MATERIAL DE POLIURETANO, E, MATERIAL DE POLIURETANO. A presente descrição refere-se aos ésteres de ácido sulfônico para uso como aditivos em uma formulação de poliuretano. A formulação de poliuretano inclui adicionalmente um composto contendo um grupo funcional isocianato, um composto contendo hidrogênio ativo e um catalisador de amina reativo.
Patent BR-112023003868-A2 (BR)
Title: Método para prevenir ou reduzir o crescimento de um tumor, agente de ligação para uso em prevenir ou reduzir o crescimento de tumor, composição imunogênica compreendendo pelo menos um antígeno de vacina para uso, usos de um agente de ligação e de uma composição imunogênica, e, kit de partes compreendendo um agente de ligação
Inventor: HREINN BENONISSON
IPC: A61P35/02
Filed: 2021-09-02
Abstract: MÉTODO PARA PREVENIR OU REDUZIR O CRESCIMENTO DE UM TUMOR, AGENTE DE LIGAÇÃO PARA USO EM PREVENIR OU REDUZIR O CRESCIMENTO DE TUMOR, COMPOSIÇÃO IMUNOGÊNICA COMPREENDENDO PELO MENOS UM ANTÍGENO DE VACINA PARA USO, USOS DE UM AGENTE DE LIGAÇÃO E DE UMA COMPOSIÇÃO IMUNOGÊNICA, E, KIT DE PARTES COMPREENDENDO UM AGENTE DE LIGAÇÃO. A presente invenção refere-se a terapia de combinação dentro do campo da oncologia; em particular, a terapia de combinação com vacinas e agentes de ligação que se ligam à CD3 e a um antígeno alvo em células tumorais.
Patent BR-112023004713-A2 (BR)
Title: Formas sólidas de um inibidor de cdk4
Inventor: WESLEY DEWITT CLARK
IPC: A61P35/00
Filed: 2021-09-13
Abstract: FORMAS SÓLIDAS DE UM INIBIDOR DE CDK4. A presente invenção refere-se a formas cristalinas e amorfas de 1,5-anidro-3-({5-cloro-4-[4-fluoro-2-(2-hidroxipropan-2-il)-1-(propan-2-il)-1H-benzimidazol-6-il]pirimidin-2-il}amino)-2,3-dideóxi-D-treo-pentitol, a composições farmacêuticas que compreendem tais formas sólidas, e ao uso de tais formas sólidas e composições farmacêuticas para o tratamento de câncer.
Patent BR-112023006178-A2 (BR)
Title: Método e analisador para a análise óptica de um líquido contendo um gás dissolvido
Inventor: HANS VILLEMOES ANDERSEN
IPC: G01N33/14
Filed: 2021-09-30
Abstract: MÉTODO E ANALISADOR PARA A ANÁLISE ÓPTICA DE UM LÍQUIDO CONTENDO UM GÁS DISSOLVIDO. Método para realizar uma análise óptica de um líquido contendo gás dissolvido compreendendo as etapas de A: transferir uma quantidade do líquido de um reservatório para uma bomba de pistão; B: manter a quantidade transferida à ou próxima à pressão ambiente para possibilitar a desgaseificação parcial; C: transferir uma amostra de líquido da bomba e para uma célula de medição sob uma pressão maior que a ambiente; e D: realizar uma análise óptica da amostra de líquido pressurizada parcialmente desgaseificada.
Patent SK-6898-A3 (SK)
Title: Soluble lymphotoxin-'beta' receptors and anti-lymphotoxin receptor and ligand antibodies, as therapeutic agents for the treatment of immunological disease
Inventor: BROWNING JEFFREY
IPC: A61P21/00
Filed: 1996-07-19
Abstract: This disclosure relates to compositions and methods comprising "lymphotoxin-² receptor blocking agents" which block lymphotoxin-² receptor signalling. Lymphotoxin-² receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, and more particularly, for inhibiting Th1 cell-mediated immune responses. This disclosure relates to soluble forms of the lymphotoxin-² receptor extracellular domain that act as lymphotoxin-² receptor blocking agents. This disclosure also relates to the use of antibodies directed against either the lymphotoxin-² receptor or its ligand, surface lymphotoxin, that act as lymphotoxin-² receptor blocking agents. A screening method for selecting soluble receptors, antibodies and other agents that block LT-² receptor signalling is provided.
Patent CH-684916G-A3 (CH)
Title: Timepiece with a world time display
Inventor: HOTZ BRUNO
IPC: G04B19/23
Filed: 1993-02-24
Abstract: Timepiece with a world time display, suitable in particular for embodiment as a pocket watch or wristwatch, which in addition to an annular dial (11) with a scale for hours and minutes has the associated hands for hours (3), minutes (4) and seconds (5). In the centre of the timepiece is a circular dial which is provided with a representation of a map of the world in a polar projection and rotates in the anticlockwise direction within 24 hours. Time zones (9) represented on the map of the world correspond to the time marks applied to the inner rim of the circular dial (2) in a reverse fashion. In order to read off the local time, use is made of a hand which is fitted above the circular dial, is coupled to the dial by means of a slipping clutch (friction clutch) and rotates with the latter. This hand can be adjusted by means of a mechanism actuated by the watch crown (case crown), and serves to read off the local time on the scale (2) for a desired location on the map of the world. The circumferential representation of the map of the world is divided into a light day half (6) and a dark night half (7) by means of a semicircular shaded disc which is permanently connected to the housing. <IMAGE>
Patent CZ-42995-A3 (CZ)
Title: Process for preparing polyakyl-1-oxa-diazaspirodecane compounds
Inventor: GAA KARL DR
IPC: C07D498/22
Filed: 1995-02-17
Abstract: The prodn. of polyalkyl-1-oxa-diazaspirodecane cpds. of formula (I) comprises reacting a cpd. of formula (IV) with an epihalohydrin of formula (V) in the mole ratio of (1:1)-(1:10) in inert solvent and in the presence of alkali hydroxide (AOH) as the sole catalyst and then (for n > 1) heating the resulting epoxide (VI) at 100-240 degrees C; after the reaction, sufficient water is added to form two phases. The AOH consists of 1-20 moles solid alkali metal hydroxide or a mixt. with water in the wt. ratio of (1:9)-(9:1). n = 1-50; Y = a gp. of formula (indices 3 and 4 indicate ring positions in I, with the N atom attached to a CH2 gp. in the propylene-2-oxy gp.); R<1> = H, O, NO gp., 1-12 C alkyl or alkoxy, allyl, 1-22 C acyl, benzyl or 3-12 C cycloalkoxy; R<2> = H or 1-5 C alkyl; R<3> + R<4> + attached C atoms = 5-6 C cycloalkyl gp. or a gp. of formula; R<5>, R<6> = H, 1-30 C alkyl or 7-12 C phenylalkyl (opt. substd. with Cl or 1-4 C alkyl); or R<5> + R<6> + attached C atom = 5-18 C cycloalkyl (opt. substd. with up to four 1-4 C alkyl gps.) or a gp. of formula; if n = 1, R<7> is absent, i.e. the O and the terminal CH2 gp. form an oxirane ring; if n = m > 1, R<7> = H or 1-22 C acyl; or R<7> may be absent in the terminal monomer unit with an oxirane ring present as above; HX = acid residue or a salt thereof with a protic acid; Hal = Cl, Br or I.
Patent CZ-84993-A3 (CZ)
Title: Process of working silicon lamellae of chips for achieving controlled sections of precipitation density
Inventor: FALSTER ROBERT
IPC: H01L21/322
Filed: 1991-11-11
Abstract: The object of the invention is a process for the treatment of silicon wafers to achieve therein controlled precipitation profiles for the manufacture of electronic components, comprising the following fundamental operations: a) subjecting the wafers to a preliminary thermal treatment, at a temperature between 950  DEG C and 1150  DEG C, in particular at about 1100  DEG C, for a duration of about 15 minutes; b) after a standard chemical corrosion (etching) treatment, subjecting pairs of coupled wafers in a close reciprocal thermal contact to a rapid thermal annealing treatment, at a temperature between 1200  DEG C and 1275  DEG C for a duration of some tens of seconds; c) subjecting the wafers to a further extended thermal treatment at a temperature between 900  DEG C and 1000  DEG C, and, finally, d) extracting the wafers from the furnace and subjecting the surfaces that were in a close reciprocal contact during the rapid annealing treatment to a surface polishing. The resulting wafers have a profile of the density of the precipitates that presents a concentration peak in proximity to a surface (trapping zone) and a very low concentration plateau in proximity to the other surface (active zone).
Patent CZ-94993-A3 (CZ)
Title: Swivel inside-threading tool
Inventor: KADERA RADOVAN
IPC: B23B27/06
Filed: 1993-05-19
Abstract: This swivel inner threading tool consists of a blade holder (1), a bearing part (2) and a fixing part (3). The blade holder (1) in its working position is equipped with a cross terminal groove (5) and a circular supporting surface (6), which fits to the bearing part (2) by its lateral circular projection (7) and the other circular supporting surface (11) with the threaded blade plate (9). The bearing part (2) is also equipped with an outer circular supporting surface (8), which is in contact with the fixing part (3) of the other inner circular surface (12).<IMAGE>
Patent CZ-246692-A3 (CZ)
Title: Strain of micro-organism candida lambica ccy 29-97-11
Inventor: PAULIKOVA HANA RNDR
IPC: C12N1/16
Filed: 1992-08-10
Abstract: A strain of micro-organism Candida lambica, which is advantageously useful in industry as a biomass producer. The strain is recorded in the Yeast Culture Register at the SAV Institute of Chemistry, Dubravska cesta 9, Bratislava, Slovakia, under demarcation CCY 29-97-11. In continual and discontinuous aerobic cultivation it quickly utilises xylose, glucose, mannose, glycerol, ethanol and malic acid, acetic acid and lactic acid during creation of biomasses. It is resistant to high concentrations of sulphur dioxide and furaldehyde.
Patent CZ-270592-A3 (CZ)
Title: Composite armour plate
Inventor: BRUININK PETER ING
IPC: F41H5/04
Filed: 1992-08-31
Abstract: Composite armour plate, comprising a metal layer and a composite layer, the composite layer comprising fibres and a polymer matrix, and the metal of the metal layer having a maximum hardness of 70 HB. The armour plate is low weight and affords good protection against ballistic impact. The preferred metals are aluminium or an aluminium alloy.
Patent CZ-282191-A3 (CZ)
Title: CIS-2,8-DIMETHYL-2,3,4,4a,5,9a-HEXAHYDRO-5-(3-PYRIDINECARBONYL) -1H-PYRIDO(4,3-b)INDOLE AND PROCESS FOR PREPARING THEREOF
Inventor: BENES LUDEK DOC RNDR DRSC
IPC: C07D209/08
Filed: 1991-09-16
Abstract: Cis-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-5-(3- -pyridinecarbonyl)-1H-pyrido (4,3-b) indole with formula I and also its salts can be prepared by reaction of pyridoindole with hydrochloride of nicotinic acid in medium of internal solvent with additive of equivalent mass of tertiary amine a.e. triethylamine by temperature 0 to 120 degrees of Celsius. This compound catchs the free oxygene radicals and can be used in pharmacy or medicine.
Patent CS-322590-A3 (CS)
Title: Process of splitting fat-containing matters for soap producing
Inventor: ASBECK LUTZ SIGHARD
IPC: C11B13/02
Filed: 1990-06-28
Abstract: The invention relates to a process for splitting soapstock, comprising the steps of mixing the soapstock with a soap splitting acid, and of separating the acid water phase formed from the oil phase, characterized in that the mixture of the soapstock and the soap splitting agent are subjected to a high temperature treatment at or above 100 DEG C during a residence time equal to or more than 2 minutes.
Patent CZ-389092-A3 (CZ)
Inventor: MIERTUS ROMAN ING
IPC: G02B6/032
Filed: 1992-12-28
Abstract: Kontinuálny výrobny postup přenosového optického prvku,
v ktorom sa súčasne s vytvarovávaním ochrannej kovověj
rúrky do nej společné jedným prívodom zavádzajú optické
vlákna a hydrotepelné médium. Po pretiahnutí optických
vlákien komorou plniacej hlavy (1) a ich upevnění v kovověj
ochrannej rúrke sa následné do komory plniacej hlavy
(1), pod ktorou sa súčasne vedie a formuje kovová páska,
privádza na teplotu 120 -180 0 C vyhriate hydrotepelné médium
pod tlakom minimálně 0,1 MPa, ktoré postupuje
rýchlosfou minimálně 0,5 m.min’1 synchronně s kontinuálnou
rýchlosfou odťahovými optickými vláknami do
ochrannej kovověj rúrky, kde sa vyvadzajú za miestom jej
zvaru. Zariadenie na vykonávanie tohto spósobu pozostáva
z plniacej hlavy (1), osadenej na nosnom ráme (2), v ktorej
je vytvořený prietokový kanálik (12), s vyúsfujúcim otvorom
(15). V plniacej hlavě (1) sú osadené dve priechodné
skrutky (4, 5), Do prvej priechodnej skrutky (4) je zavedená
vstupná rúrka (6), vyústěná v komoře (14) za vyúsfujúcim
otvorom (15). Do druhej priechodnej skrutky (5) je
upevněná odvádzacia rúrka (7), vůačšieho priemeru ako
vstupná rúrka (6), vyústěná do ochrannej kovověj rúrky za
miestom jej zvaru.
Patent CZ-174498-A3 (CZ)
Title: Process for preparing optically active cyanohydrin
Inventor: MIYAZAWA YOSHINOBU
IPC: C07C255/43
Filed: 1997-02-07
Abstract: An optically active cyanohydrin represented by the following general formula (1): <CHEM> wherein each of R1 and R2 is a hydrogen atom or an amino-protecting group, and the configurations relating to the carbon atoms at the *2-position and *3-position are as follows: in the case of the carbon atom at the *2-position being in R-configuration, the carbon atom at the *3-position is in S-configuration, and in the case of the carbon atom at the *2-position being in S-configuration, the carbon atom at the *3-position is in R-configuration, can be efficiently produced by crystallizing one of the optically active cyanohydrins while treating a mixture of cyanohydrin diastereomers in the presence of an amine and an organic solvent to change the configuration relating to the carbon atom at the 2-position and thereby cause isomerization.
Patent CZ-201955-A3 (CZ)
Inventor: VIERERBL LADISLAV
IPC: G01T3/00
Filed: 2019-02-04
Abstract: Nehomogenní transmutační detektor (ITMD) je nový typ detektoru neutronů, jehož konstrukce je založena na oddělení procesu přípravy ultra čistého substrátu (matrice, podložky) a procesu přípravy výchozího (terčového) nuklidu. Výchozí nuklid je vložen do čistého substrátu v monoizotopické formě pomocí vhodné fyzikální nebo chemické metody, např. pomocí metody iontové implantace anebo je nanensen na čistý substrát ve formě spojité tenké vrstvy nebo nespojité mikrostruktury či nanostruktury. Po ozáření ITMD v proměřovaném poli záření je detektor vyhodnocen pomocí analytické metody, která je schopna měřit hloubkové koncentrační profily s vysokou citlivostí (lepší než ppm). Ze změřených koncentračních profilů se stanoví fluence a případně spektrum neutronů. ITMD mohou dosáhnout vyšší citlivosti než doposud popsané transmutační detektory a navíc mají menší indukovanou aktivitu po ozáření.
Patent CZ-206397-A3 (CZ)
Inventor: HANULIAK ALOJZ ING
IPC: B65D41/32
Filed: 1997-06-30
Abstract: Pro nápoje všeho druhu je určena plechovka,
která má u hrdla na straně uzávěru (6) náústek
(10), který vodotěsně obepíná okraj
hrdla (4) a je opatřený víkem (11).
Patent CZ-209595-A3 (CZ)
Title: Heating chamber with fire tubes for solid material
Inventor: TRATZ HERBERT DR
IPC: F24H9/18
Filed: 1995-08-16
Abstract: The solids-heating rotary kiln is very suitable for waste (A) pyrolysis. Within (13) the drum (8), parallel tubes (12) are heated by an internal flow of hot gases (h). At the colder end of the tubes, in the last-thirds of their length, turbulators (4), i.e. turbulence inducing rings, are located on the inner tube surfaces. The rings are pref. of stainless steel, rectangular or round in cross section, and offset from each other by given distance; fastened to a pair of locating wires (42) running through, either inside or outside the rings.
Patent CZ-212599-A3 (CZ)
Inventor: BOETTCHER KARSTEN
IPC: G01R31/08
Filed: 1999-06-14
Abstract: Uzpůsobu pro rozeznávání přerušení vedení azkrácení vedení pro
zjišťování polohy pedálu vmotorovémvozidle se v krokuZA2/
vyhodnocuje značkav kroku /Al/ pro zkrácení vedení tehdy,
jestliže bylo zjištěno, že naměřené hodnoty obou snímačů hodnot
pedálu leží pod předemzadanýmpásmemhodnot Jestliže se
stanoví značka a zjistí se uvedení vozidlado pohybu z klidového
stavu, ačkoliv naměřenáhodnotaje i nadálemimo předemzadané
pásmo hodnot, pak se v kroku/A8/ konstatuje přerušení vedení v důsledku například přetržení kabelu. Jestliže se značkanestanoví,
pakse vpozdějšímčasovémokamžiku sejme naměřená hodnota
uvnitř předemzadaného pásma hodnot arozpozná se zkrácení
lO vedení na základě vysoké hodnoty ohmického odporu vzniklé v
CM důsledku usazeniny nadráze vodičů.
Patent CZ-222099-A3 (CZ)
Title: Method of restricting interference effects and interference automatic regulator, central terminal unit and wireless telecommunication system
Inventor: LYSEJKO MARTIN
IPC: H04W72/08
Filed: 1997-12-18
Abstract: The present invention provides an interference controller and method for limiting in one cell the effect of interference generated by other cells of a wireless telecommunications system, each cell of the wireless telecommunications system having a central terminal and a plurality of subscriber terminals, communication between a central terminal and a subscriber terminal being arranged to occur over a wireless link, and a plurality of code division multiplexed channels being provided within a single frequency channel to enable data items pertaining to a plurality of wireless links to be transmitted simultaneously within different code division multiplexed channels of said single frequency channel. The interference controller comprises an analyser for comparing with predetermined criteria parameters within the cell indicative of whether the code division multiplexed channels are subject to interference from signals generated by said other cells; and a channel controller, responsive to the analyser, to selectively prevent code division multiplexed channels from being used in order to reduce the effect of the interference from said other cells. In preferred embodiments, the interference controller is provided within a central terminal of at least one cell of the wireless telecommunications system.
Patent CZ-278996-A3 (CZ)
Title: Device for tilting and closing opening and tilting leaf of windows and doors
Inventor: ZIMMERMANN MICHAEL
IPC: E05D15/523
Filed: 1996-09-23
Abstract: The locking and closure mechanism (13) comprises a plate (14) possessing bolt-inlets (16,17) and positioned on the upright frame-strut in the bottom frame corner on the closure side. A tilting and locking bolt component (15) is positioned on the upright casement or leaf frame on the closure side on the bottom corner. The component has a bolt (21) resting on the bottom end of a swivel bar (23) movable parallel to a locking rail (18) and joined to a driving rod (19) by its top end via a bearing pin (24). The swivel bar with bearing pin goes through an elongated slot (25) in the locking rail. The bolt has a profiled attachment (22) on the bottom end of the swivel bar and fitting into a bolt-inlet (17). A closure cam (20) is positioned on the tilting and closure component. The closure cam and the top bolt inlets on the tilting and closure plate grip behind locking flanks pointing parallel to and crosswise to the casement's or leaf's closure plane.
Patent CZ-290599-A3 (CZ)
Inventor: SCHULTE KLAUS
IPC: B01F5/04
Filed: 1998-02-04
Abstract: Při způsobu výroby reaktivní směsi isokyanátu a polyolu se
nejprve vysokoviskózní podíl polyolu s viskozitou nejméně 3000
mPa.s vnáší zanízkého tlaku kolmo do směšovací zóny. Napříč se
za vysokého tlaku vstřikuje do tohoto nejménějednoho proudu
vysokoviskozního polyolu nízkoviskozní podíl /isokyanátu a
nízkoviskózního polyolu/. Kprovedení způsobuje vhodná
směšovací hlavice bez míchadla, se směšovací komorou,
opatřenoujednímvpouštěcímotvorempro vysokoviskózní podíl a
nejméně dvěma vypouštěcími otvory pro nízkoviskozní podíly.
Patent CZ-316594-A3 (CZ)
Title: Stomach protecting stable omeprazole preparations having the form of micro-capsules and process for preparing thereof
Inventor: DEBREGEAS PATRICE
IPC: A61K47/36
Filed: 1993-06-16
Abstract: The present invention relates to a stable formulation of omeprazole microgranules containing a neutral core consisting of sugar and starch, characterized in that it contains an active layer consisting of a dilution of omeprazole in mannitol in substantially equal amounts. It also relates to a process for producing such formulations.