baber/WOPTO huggingface dataset:
Patent CA-3124243-A1 (CA)
Title: Vaccine compositions and methods for restoring nkg2d pathway function against cancers
Inventor: DRANOFF GLENN
IPC: A61P37/04
Filed: 2015-03-16
Abstract: The present invention provides compositions and methods for treating cancer in a subject by eliciting an immune response against a MIC polypeptide.
Patent CA-3125120-A1 (CA)
Inventor: FENG XIAO
IPC: C07K16/46
Filed: 2019-12-26
Abstract: La présente invention concerne une protéine de fusion d'anticorps, son procédé de préparation et son utilisation. La protéine de fusion d'anticorps présente une quantité d'expression élevée, et une quantité d'expression transitoire dans des cellules de mammifère 293E est de 100 à 150 mg/L ; la protéine de fusion d'anticorps présente un taux d'assemblage élevé, et le taux d'assemblage exact dépasse 95 % ; la protéine de fusion d'anticorps a une affinité élevée, et une valeur KD de liaison anticorps simple face/protéine de fusion et antigène est équivalente à une valeur KD de liaison anticorps monoclonal témoin positif/protéine de fusion et antigène ; la protéine de fusion d'anticorps est pratique à purifier, et la pureté peut atteindre plus de 95 % dans une purification en une étape par utilisation d'une protéine A ou d'une protéine L, et le taux d'inhibition tumoral chez un animal d'expérience pharmacodynamique peut atteindre jusqu'à 92 %.
Patent CA-3125875-A1 (CA)
Title: Expression vector organization, novel production cell generation methods and their use for the recombinant production of polypeptides
Inventor: HUELSMANN PETER MICHAEL
IPC: C12P21/08
Filed: 2012-12-19
Abstract: Herein is reported an expression vector comprising - an antibody light chain expression cassette, - an antibody heavy chain expression cassette, and - a selection marker expression cassette, wherein the expression cassettes are arranged unidirectional, and wherein the expression cassettes are arranged in the 5' to 3' sequence of antibody heavy chain expression cassette, antibody light chain expression cassette and selection marker expression cassette. Further are reported herein methods for the generation of antibody producing cells and the use of these cells for the recombinant production of antibodies.
Patent CA-3127382-A1 (CA)
Title: Methods and systems for underwater gear tracking
Inventor: STEVENSON AARON
IPC: A01K69/08
Filed: 2020-01-22
Abstract: A method for underwater gear tracking includes receiving, by a reporting device on a vessel, from a tag associated with an item, a signal indicating the 6 item is on the vessel. The method includes determining, by the reporting device, that the item is not on the vessel. The method includes recording, by the reporting device, information associated with the environment of the vessel at a time the reporting device determines that the item is not on the vessel, without input from an operator of the vessel. The method includes recording, by the reporting device, information associated with the environment of the vessel at a time the reporting device determines that the item is not on the vessel, without input from an operator of the vessel. The method includes providing, by the reporting device, the recorded information to a computing device.
Patent CA-3127616-A1 (CA)
Title: Improved handmade article of linen and/or bedclothes
Inventor: FRANCESCATTO DANILO
IPC: A47G9/02
Filed: 2019-01-30
Abstract: An improved handmade article of linen and/or bedclothes (1 ) comprising two padded bedclothes items (2, 3) which are facing and opposite each other, are quilted according to modular squares or sectors scheme (4), comprise a plurality of inner spacer tabs (5) which are arranged inside the padded bedclothes items (2, 3) which are firmly connected with and which separate each other the quilted squares (4) of each of the padded bedclothes items (2, 3), the bedclothes items (2, 3) being also connected each other through junction means (6) in such a way as to define between the bedclothes items (2, 3) a hygroscopic interstitial chamber (7) suitable to increase the breathability and thermoregulation of the article (1 ). In particular, the spacer tabs (5) of the bedclothes items (2, 3) presents one or more through holes (8) which place the quilted squares (4) adjacent each other and belonging to the same bedclothes items (2, 3) in mutual communication, so that circulation of air (A) inside the bedclothes items (2, 3) and/or the interstitial chamber (7) is maximized or optimized.
Patent CA-3130469-A1 (CA)
Title: Agents de degradation tricycliques d'ikaros et d'aiolos
Inventor: HENDERSON JAMES A
IPC: C07D209/92
Filed: 2020-04-10
Abstract: Des liants de céréblon tricycliques de formule I sont décrits pour la dégradation d'Ikaros ou d'Aiolos par la voie d'ubiquitine-protéasome à des fins thérapeutiques.
Patent CA-3132123-A1 (CA)
Inventor: EISENBACHER EGON
IPC: F16N13/02
Filed: 2020-02-13
Abstract: The invention relates to a lubricant dispenser comprising a storage container (1) filled with lubricant and a pump (2) which is connected to or can be connected to the storage container (1) and by means of which the lubricant can be pumped out of the storage container (1). The pump has a pump housing (3) with an inlet opening (4) and an outlet opening (5), a piston (6) which is movably guided in the pump housing (3) in a linear manner, and a drive (7) which acts on the piston (6). The pump housing (3) of the pump (2) is connected to or can be connected to the storage container (1), and the piston (6) can be raised or lowered cyclically by the drive (7) in order to pump a lubricant from the inlet opening (4) to the outlet opening (5). The lubricant dispenser is characterized in that the piston (6) is designed in a stepped manner with an upper piston surface (10) which delimits an upper displacement chamber (8) and a lower piston surface (11) which delimits a lower displacement chamber (9) and is reduced compared to the upper piston surface (10). The upper displacement chamber (8) adjoins the inlet opening (4) via a first valve (13), and the first valve (13) is loaded or can be loaded into a closed base position. A through-opening (12a, 12b) which connects the upper displacement chamber (8) to the lower displacement chamber (9) with the interposition of a second valve (14) is arranged in or on the piston (6), and the lower displacement chamber (9) transitions into the outlet opening (5) via an outlet channel (16). When the piston (6) is lowered as the result of a negative pressure in the upper displacement chamber (8), the first valve opens (for example against a spring force), and lubricant is suctioned out of the storage container into the upper displacement chamber (8), but the second valve (14) closes and lubricant is pushed out of the lower displacement chamber (9) into the outlet channel (16). When the piston (6) is raised, the first valve (13) closes, but the second valve (14) opens in the piston (6), and lubricant both flows from the upper displacement chamber (8) into the lower displacement chamber (9) and is pushed from the lower displacement chamber (9) into the outlet channel (16).
Patent CA-3133291-A1 (CA)
Title: Centrifugal hydraulic seal
Inventor: SELL ANDREW G
IPC: F16J15/42
Filed: 2021-10-06
Abstract: A centrifugal hydraulic seal between the rotating and non-rotating components of rotating process equipment is provided. The centrifugal hydraulic seal reduces toxic gases inside an operating machine from escaping to the atmosphere or reduces gas from the atmosphere entering into the operating machine by the placement of protruding vanes on the face of the rotating seal wall on the low pressure side of the seal.
Patent CA-3134757-A1 (CA)
Inventor: BROWN GREGORY NELSON
IPC: A61K38/26
Filed: 2020-04-20
Abstract: The present invention provides an improved method for preparing a powder formulation containing a peptide. The present invention further provides an improved method for preparing a powder formulation containing glucagon or a glucagon analog, wherein said powder formulation is suitable for nasal administration.
Patent CA-3137968-A1 (CA)
Inventor: DHAWAN ASHISH
IPC: C09K15/00
Filed: 2020-04-28
Abstract: La présente invention concerne des composés, des compositions, et des procédés qui comprennent des amines aromatiques oxygénées, telles qu'un composé aminophénol, phényl-p-phénylènediamine, et diaminobenzène utiles comme agents antioxydants. L'amine aromatique oxygénée comprend un groupe amine secondaire et/ou tertiaire ayant un azote qui est fixé à un ou deux groupe(s) contenant du carbone, le(s) groupe(s) contenant du carbone ayant un groupe hydroxyle et/ou éther séparé de l'azote par un ou plusieurs atomes de carbone.
Patent CA-3138245-A1 (CA)
Inventor: HOLLER FRANK
IPC: A01D45/02
Filed: 2020-04-25
Abstract: L'invention concerne un rail de support d'un releveur d'épis pour un produit à récolter, ledit rail présentant une direction d'extension principale, une partie conçue sous forme de patin de glissement étant agencée entre une première extrémité et une seconde extrémité du rail de support, la partie conçue sous forme de patin de glissement étant destinée à être guidée par une face extérieure au-dessus d'un sol, et présentant une entretoise s'étendant dans la direction d'extension principale sur un côté intérieur opposé au côté extérieur. L'invention concerne également un releveur d'épis pour une faucheuse de moissonneuse, comportant un releveur de tiges de paille et un rail de support portant ledit releveur de tiges de paille.
Patent CA-3140422-A1 (CA)
Inventor: DUCKETT JEANNE
IPC: G06Q10/08
Filed: 2020-05-14
Abstract: L'invention concerne des procédés de suivi des aliments, qui améliorent l'hygiène alimentaire. Dans un mode de réalisation, l'invention concerne des procédés permettant de suivre un profil de température d'un produit alimentaire depuis son origine à sa disposition finale. Dans un autre mode de réalisation, l'invention concerne des procédés permettant d'identifier un rappel d'un article alimentaire depuis son origine à sa disposition finale. Dans encore d'autres modes de réalisation, l'invention concerne des procédés permettant de suivre un article alimentaire depuis un emplacement de service alimentaire à un consommateur.
Patent CA-3141911-A1 (CA)
Title: Tri-angled liner with jet shaper
Inventor: WILSON SHANE MATTHEW
IPC: F42B1/02
Filed: 2020-06-12
Abstract: A shaped charge having a liner with three frustoconical segments and a bottom portion configured to provide consistent perforating holes over a range of distances from the shaped charge.
Patent CA-3146555-A1 (CA)
Title: Mixed nal unit picture constraints in video coding
Inventor: WANG YE-KUI
IPC: H04N7/12
Filed: 2020-07-07
Abstract: A video coding mechanism is disclosed. The mechanism includes receiving a bitstream comprising a current picture including a plurality of video coding layer (VCL) network abstraction layer (NAL) units that do not have a same NAL unit type. Active entries of reference picture lists are obtained for slices positioned in a sub-picture A (subpicA) in subsequent pictures following the current picture in decoding order. The active entries do not refer to any reference picture preceding the current picture in decoding order when the subpicA at the current picture is associated with an intra-random access point (IRAP) NAL unit type. The subsequent pictures are decoded based on the reference picture list active entries. The subsequent pictures are forwarded for display as part of a decoded video sequence.
Patent CA-3151477-A1 (CA)
Title: Polypropylene - polyethylene blends with improved properties
Inventor: KAHLEN SUSANNE MARGARETE
IPC: C08J3/20
Filed: 2020-08-04
Abstract: The present invention refers to a polymer composition comprising at least the following components A) 20 to 75 wt.-% based on the overall weight of the polymer composition of a polymer blend, comprising a1) polypropylene; a2) polyethylene; wherein the weight ratio of a1) to a2) is from 3:7 to 12:1; and wherein the polymer blend A) is a recycled material; B) 25 to 80 wt.-% based on the overall weight of the polymer composition of a virgin heterophasic polypropylene block copolymer; whereby said virgin heterophasic polypropylene block copolymer has a xylene soluble content (XCS) determined according to ISO 16152 based on the overall weight of component B) in the range of 8 to 30 wt.-%; a C2-content in the range of 2.0 to 12.0 wt.-%; and a MFR2 (230°C, 2.16 kg) determined according to ISO 1133 in the range of 30 to 55 g/10 min; with the proviso that the weight proportions of components A) and B) add up to 100 wt.-%. In addition, the present invention relates to a process for manufacturing the polymer composition to the use of component B) for improving mechanical properties of polymer blends A) and to articles comprising the polymer composition according to the invention.
Patent CA-3155349-A1 (CA)
Title: Systeme d'evaluation de l'etat de la surface d'un pneumatique
Inventor: MOUROUGAYA FRANCOIS
IPC: G01M17/02
Filed: 2020-11-23
Abstract: L'invention concerne un système d'évaluation de la surface d'un pneumatique (10), comportant : - Une zone d'entrée (21) du pneumatique dans le système, une zone de capture, et une zone de sortie (22), distincte de la zone d'entrée, - Des moyens de mise en mouvement (23) et de maintien en position d'un pneumatique, - Des moyens d'éclairage du pneumatique permettant l'éclairage d'un flanc du pneumatique et du sommet d'un pneumatique dans la zone de capture, - Des moyens d'acquisition d'une image visuelle du pneumatique dans la zone de capture, - Des moyens de traitement de l'image acquise, au moins un moyen d'acquisition étant installé sur un axe mobile par rapport au pneumatique installé dans la zone de capture.
Patent CA-3157437-A1 (CA)
Inventor: LEE SO JIN
IPC: A61K39/00
Filed: 2020-11-05
Abstract: Disclosed are a composition for inducing immunity against an active ingredient and a method for preparing same, the composition comprising: a nucleic acid, a polypeptide, or a combination thereof as the active ingredient; a cationic compound; an amphiphilic block copolymer; and a polylactate, wherein the active ingredient is encapsulated in a nanoparticle structure formed by the amphiphilic block copolymer and the polylactate.
Patent CA-3159078-A1 (CA)
Title: Method and mobile capture apparatus for capturing elements of infrastructure of an underground line network
Inventor: PUTZ MICHAEL
IPC: G01C7/06
Filed: 2020-10-27
Abstract: The invention relates to a method and a device for detecting exposed elements of infrastructure of an underground line network, in particular in an open cut, by means of a mobile detection unit (1).
Patent CA-3159805-A1 (CA)
Title: Molecules d'acides nucleiques regulatrices pour ameliorer l'expression genique dans des plantes
Inventor: MEULEWAETER FRANK
IPC: C12N15/82
Filed: 2020-11-30
Abstract: La présente invention concerne le domaine de la biologie moléculaire des plantes et concerne des procédés de production de promoteurs à expression élevée et de production de plantes avec une expression améliorée d'acides nucléiques, les acides nucléiques améliorant l'expression d'acides nucléiques (NEENA) étant liés de manière fonctionnelle auxdits promoteurs et/ou introduits dans des plantes.
Patent CA-3161245-A1 (CA)
Title: Compositions of bile acids and phenylbutyrate compounds
Inventor: MA DAVID WAI FUNG
IPC: A61K31/192
Filed: 2020-12-15
Abstract: The present disclosure relates to compositions including a phenylbutyrate compound and a bile acid, and methods of processing such compositions.
Patent CA-3161585-A1 (CA)
Title: Novel lactobacillus having various functions and use thereof for prevention or treatment of liver injury, intestinal damage, allergy, inflammation or obesity
Inventor: KIM DONG HYUN
IPC: A61P37/08
Filed: 2016-09-07
Abstract: The present invention provides novel Lactobacillus sp.  strains, novel Bifidobacterium sp. strains, or lactic acid bacteria mixtures thereof, which are isolated from kimchi or human feces.    A certain Lactobacillus sp. strain or certain Bifidobacterium sp. strain according to the present invention is isolated from kimchi or human feces, and thus is highly safe, and has various physiological activities such as antioxidant activity,      P-glucuronidase       inhibitory                activity, lipopolysaccharide (LPS) production inhibitory activity or tight junction protein expression-inducing activity.  Accordingly, a certain Lactobacillus sp. strain, certain Bifidobacterium sp. strain or mixture thereof according to the present invention may be used as a functional food or medicinal material useful for the prevention, alleviation or treatment of intestinal damage, liver injury, allergic disease, inflammatory disease, ox obesity.
Patent CA-3161791-A1 (CA)
Title: Systeme de verrouillage mecanique pour panneaux
Inventor: BRUNO JIMMIE
IPC: A47B47/04
Filed: 2020-12-11
Abstract: L'invention concerne un ensemble de panneaux comprenant un premier panneau (1) présentant un premier plan principal et un second panneau (2) présentant un second plan principal. Le premier panneau (1) et le second panneau (2) sont munis d'un dispositif de verrouillage mécanique pour verrouiller un premier bord (11) du premier panneau (1) à un second bord (21) du second panneau (2) dans un plan de jonction (J), le premier plan principal étant essentiellement perpendiculaire au second plan principal, et le plan de jonction (J) s'étendant selon un angle par rapport au premier plan principal et au second plan principal, entre le premier plan principal et le second plan principal. L'ensemble de panneaux est caractérisé en ce que le second bord (21) comprend une première languette de bord (23), une première surface de panneau (16) du premier panneau (1) comprend une rainure de bord (12), la première languette de bord (23) étant configurée pour interagir avec la rainure de bord (12) afin de verrouiller ensemble le premier panneau (1) et le second panneau (2) dans une première direction (D1) qui est perpendiculaire au second plan principal, le second bord (21) comprend une seconde languette de bord (24), la seconde languette de bord (24) comprend une rainure de languette (22), le premier bord (11) comprend un élément de verrouillage (60). L'élément de verrouillage (60) est configuré pour interagir avec la rainure de languette (22) pour verrouiller ensemble le premier bord (11) et le second bord (21) dans une seconde direction (D2) qui est perpendiculaire au premier plan principal.
Patent CA-3162952-A1 (CA)
Title: Traitement de symptomes comportementaux et psychologiques chez des patients atteints de demence
Inventor: NIROGI RAMAKRISHNA
IPC: A61K31/496
Filed: 2020-12-02
Abstract: La présente invention concerne une méthode de traitement de symptômes comportementaux et psychologiques chez un patient atteint de démence, consistant à administrer une dose efficace d'un antagoniste pur des récepteurs 5-HT6, la masupirdine, ou d'un de ses sels pharmaceutiquement acceptables, soit seul soit en combinaison avec un inhibiteur de l'acétylcholinestérase tel que le donépézil et un antagoniste des récepteurs NMDA (N-méthyl-D-aspartate), la mémantine. La présente invention concerne en outre l'utilisation dudit composé dans la fabrication d'un médicament et de compositions pharmaceutiques comprenant lesdits composés destinés au traitement des troubles décrits ici.
Patent CA-3164665-A1 (CA)
Inventor: KRAUTHAMER AKIVA MEIR
IPC: A63J5/02
Filed: 2021-01-21
Abstract: An augmented reality system includes a first scene and a second scene. Further, the augmented reality system includes a partially reflective surface positioned relative to the first scene, the second scene, and an audience to facilitate viewing of one of the first scene or the second scene through the partially reflective surface and to facilitate reflection of the other of the first scene or the second scene toward the audience as augmented reality imagery. A sensor of the augmented reality system is designed to detect and generate data indicative of a characteristic of the first scene, and a correlative effect system is operable to receive the data and adjust the second scene based thereon.
Patent CA-3164780-A1 (CA)
Title: Travel size deodorant dispenser with improved cap
Inventor: MORROW RICHARD P
IPC: A45D33/00
Filed: 2020-12-17
Abstract: A device for the application of a gel or solid substance to a human body surface is disclosed. The apparatus is comprised of an applicator portion to which gel or solid deodorant is secured and which is coupled to a handle portion. The applicator portion is sized to accommodate a single application of deodorant in a compact format while the handle portion is sized to be grasped between the fingers and thumb of the human hand. The handle portion comprises a moveable connecting point allowing the handle portion to traverse between a storage position and a gripping position during use. The applicator portion is integrally formed with said handle portion.
Patent CA-3165967-A1 (CA)
Title: Proximity detection for a surgical light
Inventor: WESTENFELDER II DAVID A
IPC: A61B90/30
Filed: 2021-01-20
Abstract: A surgical light head and proximity detection method includes a housing, a plurality of light emitting elements arranged in the housing and configured to direct light at a target region of interest, and a plurality of distance sensors arranged in the housing. At least two of the distance sensors have field of views that overlap to define a common detection region of interest and the common detection region of interest at least partially overlaps with the target region of interest. The light head may have a plurality of integrally formed tilted seats that position the distance sensors relative to a center line of focus of the surgical light head. The distance sensors may be integrated in the housing via an optical component that is sealed relative to the housing and covers the distance sensor while enabling transmission and receipt of distance sensing signals therethrough.
Patent CA-3166104-A1 (CA)
Inventor: STAECKER HINRICH
IPC: A61K35/761
Filed: 2021-02-04
Abstract: The present disclosure describes gene therapy systems, and related methods, useful for treating and/or preventing deafness caused by genetic mutation of the TMPRSS3 gene or the LOXHD1 gene. The compositions and methods disclosed herein use adeno-associated viral (AAV) vector gene delivery of TRMPSS3 or LOXHD1 into the inner ear to restore activity of the TMPRSS3 gene or the LOXHD1 gene, respectively, promote hair cell survival and restore hearing in patients suffering from hearing loss. As disclosed herein, the systems and methods may utilize a combination of gene therapy (e.g., molecular therapeutics) for hearing loss caused by a genetic mutation together with implantation of a cochlear implant.
Patent CA-3166960-A1 (CA)
Title: An adaptor for a medical container and a medical container comprising said adaptor
Inventor: EUVRARD NICOLAS
IPC: A61M39/10
Filed: 2021-02-16
Abstract: An adaptor for a medical container and a medical container comprising said adaptor The present invention relates to an adaptor (1) for connecting a medical container to a connector, the adaptor (1) comprising longitudinal projections (5) comprising a distal portion (6) configured to exert a progressively increasing radial pressure on connecting means of the connector when said connector is moved axially proximally within the adaptor (1) and a proximal portion (7) configured to authorize the partial release of said pressure as the connector is moved further proximally, said proximal portion (7) being further configured to be contacted by said connecting means upon said partial release of said pressure and to emit a sound when contacted by said connecting means, thereby providing an end user with a tactile and audible indication that the connection between the connector and the adaptor (1) is secured. The invention also relates to a medical container having such an adaptor mounted onto its distal tip.