baber/WOPTO huggingface dataset:
Patent JP-3196079-B2 (JP)
IPC: A61K47/48
Filed: 1990-11-30
Granted: 2001-08-06
Abstract: A DNA fragment distinct from the epidermal growth factor receptor (EGFR) and erbB-2 genes was detected by reduced stringency hybridization of v-erbB to normal genomic human DNA. cDNA cloning revealed a predicted 148 kd transmembrane polypeptide with structural features identifying it as a member of the erbB family, prompting designation of the new gene as erbB-3. It was mapped to human chromosome 12q11-13 and was shown to be expressed as a 6.2 kb transcript in a variety of normal tissues of epithelial origin. Markedly elevated erbB-3 mRNA levels were demonstrated in certain human mammary tumor cell lines. These findings indicate that increased erbB-3 expression, as in the case of EGFR and erbB-2, plays a role in some human malignancies. Using erbB-3 specific antibodies (polyclonal or monoclonal), the erbB-3 protein was identified as a 180 kDa glycoprotein, gp180erbB-3. The intrinsic catalytic function of gp180erbB-3 was uncovered by its ability to autophosphorylate in vitro. Ligand-dependent signaling of its cytoplasmic domain was established employing transfectants which express a chimeric EGFR/erbB-3 protein, gp180EGFR/erbB-3. EGF induced tyrosine phosphorylation of the chimera and promoted soft agar colony formation of such transfectants. These findings, combined with the detection of constitutive tyrosine phosphorylation of gp180erbB-3 in 4 out of 12 human mammary tumor cell lines, implicate the activated erbB-3 product in the pathogenesis of some human malignancies. Thus, this invention also relates to procedures for targeting a therapeutic drug to cells having a high level of the receptor protein.
Patent JP-3184218-B2 (JP)
IPC: A61K41/00
Filed: 1992-06-05
Granted: 2001-07-09
Abstract: A porphycene having the structure  <IMAGE>  wherein each R1 is, independently, (a) -(CH2)n-X, where n=1-4, X is OR2 and R2 is C1-6 alkyl, aralkyl or aryl; CN; OH; OSO2R2; NH2; NHR2; NR22; SH; SR2; S(O)1-2R2; COOH; CO2R2; C(O)NH2; C(O)NHR2; C(O)NR22; halogen; or CHO; (b) -(CH2)mCH=CH2 where m is 0-2; or (c) -(CH2)n-O-G where G is a mono- or oligosaccharide; (d) -(CH2)2n-X, where X is an amino acid, oligopeptide covalently bonded by an ether-, ester- or amine-bond or -Y-(CH2)n-porphycene2 (porphycene2 being a compound of the same structure and Y is a direct bond; -O-; or -CH=CH2); or (e) where one, two or three of the substituents R1 are C1-6 alkyl or aryl and the remaining substituents are as above under (a)-(d), and salts and metal complexes thereof. The porphycene compounds and pharmaceutical compositions containing the compounds are useful in photodynamic therapy treatment of tumors and psoriasis.
Patent JP-2843627-B2 (JP)
IPC: C07D207/34
Filed: 1989-02-22
Granted: 1999-01-06
Abstract: An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(+/-)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(te trahy dro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro- alpha -[2-methyl-1-oxopropyl]- gamma -oxo-N, beta -diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrah ydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.
Patent JP-2980688-B2 (JP)
IPC: G01N27/12
Filed: 1995-05-12
Granted: 1999-11-22
Abstract: In a gas sensor for sensing reducing or oxidizing gases which comprises a semiconductive metal oxide film, there are provided stripe-like outer electrodes which define therebetween a continuous surface area and stripe-like inner electrodes which extend between, and parallel to, the outer electrodes so as to divide the continuous surface area into longitudinal segments which have different properties with respect to reducing or oxidizing gases such that different conductivity changes are generated for the different segments upon exposure to oxidizing or reducing gases.
Patent JP-H0789954-B2 (JP)
IPC: C12N5/07
Filed: 1991-01-22
Abstract: For the propagation or maintenance of cells in vitro, a culture medium which does not require CO2 in excess of the concentration found in ambient air is described. The medium contains the free base forms of L-arginine, L-cysteine, L-histidine, L-lysine and L-tyrosine; biotin; fatty acids; pyruvate; asparagine; low levels of sodium bicarbonate and is buffered with  beta -glycerophosphate. Te use of the medium to culture tumor cells to test anti-tumor compounds is also disclosed.
Patent JP-2918895-B2 (JP)
IPC: C12N15/31
Filed: 1988-08-26
Granted: 1999-07-12
Abstract: The development of subunits and subunit analogs of the Bordetella exotoxin by recombinant DNA techniques provides vaccine products that retain their biological activity, are highly immunogenic, and can confer protection against disease challenge. Genetically-engineered modifications of the subunits can result in products that retain immunogenicity, yet are free of enzymatic activity associated with toxin of reactogenicity.
Patent JP-3015100-B2 (JP)
IPC: B23H1/02
Filed: 1990-06-06
Granted: 2000-02-28
Abstract: PCT No. PCT/CH90/00142 Sec. 371 Date Dec. 10, 1990 Sec. 102(e) Date Dec. 10, 1990 PCT Filed Jun. 6, 1990 PCT Pub. No. WO90/14917 PCT Pub. Date Dec. 13, 1990.An impulse generator for the spark erosive cutting of workpieces by electrodes of a liquid or solid medium, consists of a control circuit and a principal circuit. The control circuit contains: the control circuit contains an oscillator, reduction stages for the generation of elements which belong to the impulse signal, a counter for the addressing of impulse signal, a memory of a feedback circuit which detects the electrical conditions in the working gap, and a ROM with programmed memory locations, which are addressed by the counter according to the addresses of the impulse elements and by memory according to the addresses of the electrical conditions in the working gap, whereby the contents of the memory locations generate an output signal or no output signal. The principal circuit contains two electronic switches for the generation of a working impulse in the working gap when an output signal is present, and a control circuit which inhibits only one of two electronic counters.
Patent JP-3435694-B2 (JP)
IPC: F17C13/02
Filed: 1993-09-02
Granted: 2003-08-11
Abstract: In the method of the invention, an unknown mass fraction (F) of solid cryogen in a stored cryogenic refrigeration system is determined. The method includes the steps of adding mass (T) of a trace substance which is soluble in the liquid phase of the system. The total mass amount (M) of the cryogen in the system is determined at the time of charging the system. The initial mass concentration (CI) of the trace substance is determined by dividing (T) by (M). During operation of the stored cryogenic refrigeration system, a small sample of the liquid phase cryogen is extracted from the system. The sample is analyzed to determine the new concentration (CN) of the trace substance in the sample. The new concentration (CN) of the sample is dependent on the amount of solid cryogen which has been produced in the system. Thereafter, the mass fraction (F) of solid cryogen in the system is determined by solving the equation: F=1-(CI/CN)
Patent JP-4246796-B2 (JP)
IPC: F16B2/06
Filed: 1996-09-20
Granted: 2009-04-02
Abstract: PCT No. PCT/GB96/02328 Sec. 371 Date Mar. 11, 1998 Sec. 102(e) Date Mar. 11, 1998 PCT Filed Sep. 20, 1996 PCT Pub. No. WO97/11279 PCT Pub. Date Mar. 27, 1997A pipe or tube clamp is disclosed. The clamp has two U-shaped elements fixed to a plate. A screw interposed between the plate and a clamping member supplies pressure to a pair of tubes to urge them together against reaction in the U-shaped members. The tubes may be either parallel or orthogonally arranged.
Patent JP-2883735-B2 (JP)
IPC: G11B27/32
Filed: 1994-10-13
Granted: 1999-04-19
Abstract: A system for playing a selected one of multiple subtitle tracks recorded in a synchronized fashion with a motion picture on an optical disk (23). Individual subtitle tracks in numerous languages may be provided for the same motion picture, with or without multiple soundtracks. The user may select a soundtrack in his/her language if it is available. If not, subtitles can be displayed in a selected language.
Patent JP-4011119-B2 (JP)
IPC: B63H1/10
Filed: 1997-05-14
Granted: 2007-11-21
Abstract: A vertical axis and transversal flow nautical propulsor continuously self-orients the blades. The propulsor includes a plurality of blades rotatable about a vertical axis; a blade supporting plate for supporting the blades, wherein the blade supporting plate is rotatable about a vertical axis independent of rotation of the blades; a motor for rotating the blade supporting plate; a motor for each blade, for rotating the blade about its own vertical axis; and a rotatable shaft. The rotatable shaft is supported by a rotor body coupled with the blade supporting plate. A plurality of spindles are provided on the rotatable shaft, wherein the spindles are coaxial with one another and with the rotatable shaft. The number of spindles corresponds to the number of blades, and the spindles are rotatable independent of one another in such a way to allow independent rotation of the relevant blade. The rotatable shaft and the spindles each have an inner end within the rotor body and an outer end outside the rotor body. The inner and outer ends of each of the spindles includes first motion transfer equipment for transferring motion from the relevant electric motor to the relevant rotating blade, and the blade axis and the axis of the relevant electric motor include corresponding second motion transfer equipment for transferring motion to the first motion transfer equipment. An interface unit is provided between an operator and a propulsor electronic control unit, wherein the motors are controllable by the electronic control unit in such a way to adjust a position and an orientation of the relevant blade in order to obtain, for any operative situation, an optimal performance over an entire operative range of the propulsor.
Patent JP-4318753-B2 (JP)
IPC: C07C229/44
Filed: 1997-09-19
Granted: 2009-08-26
Abstract: The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon multiple bonds, nitrile groups, imino groups or carbonyl groups. The preparation is carried out by catalytic hydrogenation of the corresponding aromatic nitro compounds in the presence of a phosphorus-modified noble metal catalyst. The invention relates also to the use of modified noble metal catalysts for the hydrogenation of aromatic nitro compounds containing carbon multiple bonds and/or substituted by nitrile, imino or carbonyl groups.
Patent JP-4571712-B2 (JP)
IPC: H04L29/08
Filed: 1997-11-13
Granted: 2010-10-27
Abstract: A system and method for conducting commerce over a distributed network manage merchant and product information in an electronic shopping basket, payment source information in an electronic wallet, and shipping address information in an electronic address book, all of such information being stored on a consumer computer. A commerce client running on the consumer computer is configured as a MIME handler and extends the functionality of a standard Web browser to support computer-based shopping. A merchant site Web server provides HTML-coded Web documents which describe merchant products and which host computer-based shopping options. The HTML-coded Web documents contain function-calling information by which consumer-selected options invoke shopping-related functions on either the merchant (server) computer or the consumer (client) computer. A consumer selects the options from within the Web browser to initiate shopping-related operations such as: retrieve product information from merchants on the World Wide Web, selectively store product information locally on the consumer computer, locally compare product information from different merchants, locally store payment source and shipping address information and selectively forward such information to merchant sites, order products from Web-based merchants, track the status of purchase orders, and receive instructional information on application usage.
Patent JP-4055959-B2 (JP)
IPC: A61M16/00
Filed: 1998-10-26
Granted: 2008-03-05
Abstract: The tubular respiratory assistance apparatus comprises a main channel linked by its distal end to the airway of a patient It also has at least one auxiliary channel associated with a deflector used for injecting a jet of respiratory gas into the main channel and then to ventilate the patient. On its distal side the tubular component is surrounded by an annular chamber which is connected to the patient's respiratory system via an orifice and has a branch linking the chamber's proximal end to the outside atmosphere. An Independent claim is also included for an assisted respiratory mask for application to the face of a patient comprising a nozzle for the inlet and outlet of the respiratory gas, and the apparatus is as above.
Patent JP-3226283-B2 (JP)
IPC: G02B6/024
Filed: 1997-01-21
Granted: 2001-11-05
Abstract: The invention provides improved methods for reducing polarization mode dispersion (PMD) in single mode fiber by spinning the fiber during the drawing process in accordance with a spin function having sufficient harmonic content to achieve low levels of PMD for commercial fibers for which the beat lengths of the fibers, including the beat lengths of different portions of the fibers, are variable and thus not readily known in advance. The spin functions of the invention take advantage of certain resonances in energy transfer between polarization modes to achieve substantial reductions in PMD for a wide range of beat lengths. Examples of suitable spin functions include frequency-modulated and amplitude-modulated sine waves.
Patent JP-4025926-B2 (JP)
IPC: A61B5/0476
Filed: 1997-12-19
Granted: 2007-12-26
Abstract: The disclosed filter removes cardiac artifacts from signals representative of a patient's cerebral activity. The filter preferably replaces portions of the signal including artifacts with temporally adjacent artifact free portions.
Patent JP-3782463-B2 (JP)
IPC: A47L15/00
Filed: 1998-01-30
Granted: 2006-06-07
Abstract: A washing appliance comprising a cabinet, a wash system slidably mounted within said cabinet in such a manner that it may be withdrawn horizontally out of said cabinet for access thereto, said wash system including an open top wash chamber adapted to accommodate items to be washed and within which wash liquid is circulated, said wash chamber having a top peripheral rim, means for introducing and circulating wash liquid within said chamber, means for evacuating wash liquid from said chamber, a wash chamber closure mounted in the top of said cabinet, which closure covers the open top of said wash chamber on retraction of the wash chamber into said cabinet, said closure having peripheral means which co-operate with the top of said chamber in the vicinity of said rim to prevent egress of wash liquid from the wash chamber when it is retracted into said cabinet, and said closure being retained in a substantially fixed vertical position in the top of said cabinet.
Patent JP-3786711-B2 (JP)
IPC: G02B21/26
Filed: 1998-02-05
Granted: 2006-06-14
Abstract: Systems and methods for laser capture microdissection are disclosed. One method incorporates the step of changing the beam diameter of the laser to adjust the size of the activated area of the transfer film and as a result, the size of the at least one microdissected portion of the sample adhered to the transfer film. Changing the beam diameter while operating the laser in idle mode permits the user to visualize the spot on the desired portion of the tissue sample and simultaneously increase or decrease the beam spot to optimally match the beam spot size with the portion of the tissue to be extracted. This method advantageously provides increased accuracy in microdissection and reduced heating of the tissue sample.
Patent ES-2303757-B2 (ES)
Title: Transmision para tractor.
Inventor: TSUJI KENICHIRO
IPC: F16H63/32
Filed: 2006-02-16
Granted: 2009-09-11
Abstract: Transmisión para tractor. 
     Una transmisión para un tractor que comprende
una caja de transmisión  con una abertura que desemboca en el
exterior de esta última y un dispositivo de  cambio de velocidad que
está alojado en dicha caja de la transmisión. La  transmisión
incluye también una tapa sujeta de modo desmontable a su caja para 
cerrar la abertura de la transmisión, una horquilla variadora de
cambio de  velocidad principal soportada por la tapa y capaz de
acoplarse con un variador de  cambio de velocidad principal y de
moverlo, y una horquilla variadora de cambio  de velocidad
secundaria soportada por la tapa y capaz de acoplarse con un 
variador de cambio de velocidad secundaria y de moverlo. La tapa
puede llevar  montado un dispositivo de cambio de velocidad lenta
dotado de una posición de  velocidad lenta.
Patent ES-2345600-B2 (ES)
Title: Panel flexible de hormigon reforzado con fibras de vidrio y aislamiento.
Inventor: NUNEZ JARAMILLO ANTONIO
IPC: D04H13/00
Filed: 2010-02-17
Granted: 2011-02-14
Abstract: Panel flexible de hormigón reforzado con fibras
de vidrio y aislamiento. 
     La invención se refiere a un material compuesto
por telas plásticas, cemento, áridos, fibras de vidrio y material
aislante. Este material, una vez fabricado, en contacto con el agua
endurece y adquiere las características mecánicas del hormigón
reforzado con las fibras de vidrio. 
     Compuesto en sus caras exteriores por dos telas
de material plástico cosido para evitar la salida del cemento, pero
que a su vez permite el paso del agua para hidratar el cemento. En
los laterales de ésta unos topes de material plástico
termoendurecible. Interiormente dos capas (superior e inferior) de
hormigón en seco adecuadamente dosificado (con áridos, y otros
compuestos químicos) y las fibras. 
     En la parte central se coloca una capa de
esferas de porexpan o algún otro material aislante similar, con el
espesor necesario para el fin al que se destine. 
     Todo el conjunto es prensado y cosido.
Patent IE-S86497-B2 (IE)
Title: Debit and credit card payment pin processing using http and ussd service
Inventor: FOLEY ANA MARIE CHAN
IPC: H04M1/00
Filed: 2013-09-10
Abstract: The present invention relates to the debit and credit card payment processing by collecting the Personal Identification Number of the cardholder through his/her own mobile phone. The only requirement for the mobile phone is a GSM signal whereby the telco sends the request to enter the PIN number using USSD session. This session is securely transmitted using GSM encryption or 3DES encryption process. Once received, the payment processing server sends the information through SSL encryption for validation of the information from the bank network and card issuer. The process will allow for a quick and mass market usage of PIN based card whether its debit or credit card without compromising security process. It is specific to the processing of Personal Identification Number transmission to and from the issuing bank without comprising the security and integrity of the cardholders’ information and bank network. <Figure 1>
Patent AU-2001286093-B2 (AU)
Title: Method of magnetic resonance investigation of a sample using a nuclear spin polarised MR imaging agent
Inventor: PETERSSON STEFAN
IPC: G01R33/483
Filed: 2001-09-11
Granted: 2006-03-16
Abstract: The present invention provides a method of contrast enhanced magnetic resonance imaging of a sample, said method comprising: a) administering a hyperpolarised MR contrast agent comprising non-zero nuclear spin nuclei into said sample for fluid dynamic investigations of the vasculature, b) exposing said sample or part of the sample to radiation of a frequency selected to excite nuclear spin transitions in said non-zero nuclear spin nuclei, c) detecting MR signals from said sample using any suitable manipulation method including pulse sequences. The invention also provides novel compounds.
Patent AU-2002334258-B2 (AU)
Title: Modified peptides and their use for the treatment of autoimmune diseases
Inventor: ZIMMER ROBERT H
IPC: A61K38/00
Filed: 2002-09-06
Granted: 2008-08-21
Abstract: A modified peptide in which at least one of the amino acid residues constituting the peptide has been chemically modified, by phosphorylation, acetylation or methylation, in particular peptide of sequence RIHMVYSKRSGKPRGYAFIEY [SEQ ID NO: 1].
Patent AU-2003205910-B2 (AU)
Title: Oxa- and thiadiazoles and their use as metalloproteinase inhibitors
Inventor: DAVIES STEPHEN JOHN
IPC: A61P9/10
Filed: 2003-02-20
Granted: 2008-12-04
Abstract: Compounds formula (IA) or (IB), wherein W represents HO(C═O)—, HONH(C═O)— or H(C═O)N(OH)—; X represents —O— or —S—; and R1, R2, and R3 are as defined in the description and claims, are inhibitors of matrix metal oproteinases, in particular MMP9 and/or MMP12.
Patent AU-2003219922-B2 (AU)
Title: Compositions for delivery of therapeutics and other materials, and methods of making and using the same
Inventor: BOLOTIN ELIJAH M
IPC: A61K47/30
Filed: 2003-02-27
Granted: 2009-09-10
Abstract: In part, the present invention is directed to biocompatible compositions comprising a carrier with a first metal binding domain, a metal ion, an active agent with second metal binding domain and optionally a protective chain covalently attached to the polymeric carrier.
Patent AU-2003232608-B2 (AU)
Title: Carriage
Inventor: FRICKER SIEGFRIED
IPC: A63B55/60
Filed: 2003-04-15
Granted: 2008-09-11
Abstract: A carriage for transporting a container has a chassis and at least three wheels connected to the chassis for supporting the chassis, wherein the at least three wheels include two rear wheels. A handlebar is connected to the chassis for guiding the carriage in a state of use, wherein the carriage can be converted from the state of use into a transport state. A handle is connected to the handle bar. The rear wheels are provided with halfshafts that are fastened detachably on the chassis. The chassis has securing elements for securing the rear wheels on the chassis in the transport state.
Patent AU-2003249556-B2 (AU)
Title: Getter support assembly for a solar energy collector system
Inventor: KLAPWALD SHMUEL
IPC: F24S10/40
Filed: 2003-08-07
Granted: 2008-11-06
Abstract: A getter support assembly for supporting getters in a focusing collector type solar collector system comprising a tube radiation absorber (TRA) and a glass enclosure tube, defining therebetween an annular space, and a solar radiation focusing reflector. The getter support assembly comprises a bridge formed with an elongated trough having a getter support portion. The bridge further comprising feet fixedly attached to the TRA supporting the trough so that the trough is spaced apart from the TRA. The trough further comprises a radiation reflecting surface facing the TRA for blocking radiation emitted from the TRA and missed solar radiation reflected from the reflector.