Patent SG-11201903132Y-A (SG)
Title: Pharmaceutical complex preparation comprising amlodipine, losartan and rosuvastatin
Inventor: CHO HYUK JUN
IPC: A61K9/28
Filed: 2017-11-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 24 May 2018 (24.05.2018) WIPO I PCT omit VIII °nolo ommillionoiliflo (10) International Publication Number WO 2018/093096 A2 W O 20 18/093096 A2 (51) International Patent Classification: A61K 9/24 (2006.01) A61K 31/4422 (2006.01) A61K 9/28 (2006.01) A61K 31/505 (2006.01) A61K 9/20 (2006.01) A61K 31/4178 (2006.01) (21) International Application Number: PCT/KR2017/012703 (22) International Filing Date: 10 November 2017 (10.11.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10-2016-0152077 15 November 2016 (15.11.2016) KR (71) Applicant: HANMI PHARM. CO ., LTD. [KR/KR]; 214, Muha-ro, Paltan-myeon, Hwaseong-si, Gyeonggi-do 18536 (KR). (72) Inventors: CHO, Hyuk Jun; B-301, 46, Deogyeong-daero 38 lbeon-gil, Jangan-gu, Suwon-si, Gyeonggi-do 16358 (KR). LIM, Sol Ee; #905, 17-9, Gwongwang-ro 196beon- gil, Paldal-gu, Suwon-si, Gyeonggi-do 16488 (KR). IM, Ho Taek; 117-1204, 27, Yonggu-daero 2394beon-gil, Gi- heung-gu, Yongin-si, Gyeonggi-do 16909 (KR). KIM, Yong Il; 732-504, 52, Jeongja-ro 42beon-gil, Jangan-gu, Suwon-si, Gyeonggi-do 16325 (KR). PARK, Jae Hyun; 311-404, 460, Yeongtong-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16707 (KR). WOO, Jong Soo; 120-2303, 85, Hwasan-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16420 (KR). (74) Agent: KIM, Sung Ho et al.; (WANNABE Patent & Law Firm), (Hongeun Bldg., Yeoksam-dong), 5F, 8, Teheran-ro 8-gil, Gangnam-gu, Seoul 06233 (KR). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: PHARMACEUTICAL COMPLEX PREPARATION COMPRISING AMLODIPINE, LOSARTAN AND ROSUVAS- = TATIN Amlodipir e, 011.2, 1 5Orpm -4.- Prep. ELI -IR- Exampie.1. --11e- &le Eitithiple -tit Example 4 ; —0— Example:A 20 ELMO! 9 - Comp. Ex. 2 Comp. Ex. (57) : The present invention relates to a pharmaceutical complex preparation including amlodipine, losartan and rosuvastatin as active ingredients. The pharmaceutical complex preparation of the present invention including amlodipine, losartan and rosuvastatin as the active ingredients exhibits excellent dissolution characteristics of all the active ingredients, and also has improved preparation stability. Therefore, the complex preparation of the present invention can be used as a prophylactic or therapeutic agent for cardiovas- cular diseases, which has ensured quality stability even when stored for a long period of time. [Continued on next page] WO 2018/093096 A2 MIMMOMMIONMEHMENNHOMMEMIE Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g))