baber/WOPTO huggingface dataset:
Patent JP-6209566-B2 (JP)
IPC: C12N15/09
Filed: 2015-07-30
Granted: 2017-10-04
Abstract: Sustained transgene expression will be required for the vast majority of genetic diseases being considered for gene therapy. The initially high levels of expression attained with plasmid DNA (pDNA) vectors containing viral promoters, such as that from cytomegalovirus (CMV), decline precipitously to near background levels within 2 to 3 weeks. We have constructed pDNA vectors containing the human cellular ubiquitin B (Ub) promoter and evaluated their expression in the mouse lung. Cationic lipid-pDNA complexes were instilled intranasally (IN) or injected intravenously (IV) into immunodeficient BALB/c mice. Chloramphenicol acetyltransferase (CAT) reporter gene expression from the Ub promoter was initially very low at day 2 post-administration but by day 35 exceeded the level of expression attained from a CMV promoter vector by 4- to 9-fold. Appending a portion of the CMV enhancer 5' of the Ub promoter (CMV-Ub) increased CAT expression to nearly that of the CMV promoter and expression persisted in the lung for at least three months, with 50% of day 2 levels remaining at day 84. In the liver, expression from the CMV-Ub hybrid promoter was sustained for 42 days. Since previous studies have shown that eliminating immunostimulatory CpG motifs in pDNA vectors reduces their toxicity, we constructed a CpG deficient version of the CMV-Ub vector expressing alpha-galactosidase A, the enzyme that is deficient in Fabry disease, a lysosomal storage disorder. After IN or IV administration, levels of alpha-galactosidase A from this vector were not only undiminished but increased 500% to 1500% by day 35. These results suggest that CpG-reduced plasmid vectors containing a CMV-Ub hybrid promoter may provide the long-term expression and efficacy required for a practical gene therapeutic.
Patent FR-3110241-B3 (FR)
Title: Récipient de test pour tester des dispositifs d’inspection
Inventor: SCHOBER STEFAN
IPC: G01N21/90
Filed: 2021-04-16
Granted: 2022-05-13
Abstract: La présente invention concerne un récipient d'essai (10) pour le contrôle de dispositifs d'inspection, comportant un corps de base (4) et un fond de récipient (42) ainsi qu'une embouchure (8) sur laquelle peut être disposée une fermeture (12), le récipient d'essai étant rempli d'un liquide et comportant un corps d'essai (14) qui est disposé à l'intérieur du récipient d'essai (10) et qui peut être détecté parle dispositif d'inspection dans lequel le corps d'essai (14) est disposé sur un corps en forme de tige (16) faisant saillie à l'intérieur du conteneur d'essai (10), le corps en forme de tige (16) étant au moins partiellement transparent aux rayonnements, en particulier aux rayonnements X.
Patent FR-3117062-B3 (FR)
Title: Film mince pour des cassettes d’emballage de déchets
Inventor: GINOSATIS DIMITRIS
IPC: B65F1/14
Filed: 2021-11-30
Granted: 2022-12-02
Abstract: L’invention concerne un film multicouche avec un poids inférieur à 20 g/m² pour une utilisation dans l’emballage d’articles malodorants, dans lequel le film comprend deux couches extérieures comprenant un copolymère d’éthylène/alpha-oléfine
Patent DE-10310745-B3 (DE)
Title: Milling tool for calibrated metal test piece, has one blade set for surface milling, and one blade set for conical chamfering, arranged offset in axial displacement direction
Inventor: HAWICKHORST GUENTHER
IPC: B23C5/00
Filed: 2003-03-10
Granted: 2005-01-13
Abstract: The tool includes one blade set (2) for surface-milling a planar front face (10) of the metal test piece (12) by transverse displacement, and a second blade set (18) for conical chamfering of an edge (11) of the metal test piece by axial displacement, arranged radial within the first blade set. The second blade set is offset from the first blade set in the axial displacement direction. An independent claim is included for a milling machine.
Patent DE-10318322-B3 (DE)
Title: Stopping point for a cable protection for a roof comprises a tubular sleeve surrounding a holding rod tensioned between a base plate connected to a roof and a hanging eyelet
Inventor: STEINMETZ JUERGEN
IPC: E04G21/32
Filed: 2003-04-19
Granted: 2004-11-04
Abstract: Stopping point comprises a tubular sleeve surrounding a holding rod (1) tensioned between a base plate (3) connected to a roof and a hanging eyelet. The sleeve is plastically deformed on its lower end. Preferred Features: A lower square or triangular plate (4) having a middle opening (5) is arranged to slide on the holding rod at a small distance above the base plate. The diameter of the peripheral circle of the lower plate is slightly smaller than the inner diameter of the sleeve. The upper end of the sleeve is held by an annular plate which has a middle opening for the protruding holding rod.
Patent DE-10319850-B3 (DE)
Title: Sales stand for foil or material webs stored on rolls has frame supporting parallel rolls pivoted between horizontal and vertical positions
Inventor: EIZENHOEFER GERD
IPC: A47F7/17
Filed: 2003-05-03
Granted: 2004-08-19
Abstract: The sales stand has a frame (12) provided with several support axes for respective foil or material web rolls (16) and a parallel cutting rail (22), having a blade for separation of a required length of one of the foil or material webs. The frame is mounted on a wheeled support frame and pivoted about a horizontal axis between a locked position in which the foil or material web rolls lie horizontally and a locked position in which they extend vertically.
Patent DE-10323094-B3 (DE)
Title: Electrical power switch has switch shaft supported by bearings provided by one housing shell with fixings between housing shells provided by shaft bearing and second housing shell
Inventor: DAHL JOERG-UWE
IPC: H01H71/10
Filed: 2003-05-16
Granted: 2004-08-12
Abstract: The power switch (10) has a switch pole housing (14) for receiving at least one switch pole (22) having switch contacts engaging one another in a given contact plane in the closed switch position, a switch shaft (12) transmitting drive forces to the switch poles. The switch pole housing is assembled from 2 housing shells (16) having a separation joint parallel to the contact plane, the switch shaft supported by at least 2 bearings (20) provided by one of the housing shells, with fixings securing the housing shells together provided by the second housing shell and one of the switch shaft bearings.
Patent DE-10332439-B3 (DE)
Title: Zweilagen-Synthetik Filterelement
IPC: B01D46/00
Filed: 2003-07-16
Granted: 2004-12-30
Abstract: Die vorliegende Erfindung betrifft ein mehrschichtiges, plissierfähiges Filtermaterial zur Filtration von Feststoff-Partikeln aus Fluiden, insbesondere aus Gasen, welches aus mindestens einer schmelzgeblasenen Vliesstoff-Lage und aus mindestens einer kardierten Vliesstoff-Lage besteht, die klebstofffrei miteinander verbunden sind, wobei das kardierte Vlies verdichtete und unverdichtete Bereiche aufweist, und wobei das schmelzgeblasene Vlies mit dem kardierten Vlies vornehmlich in dessen unverdichteten Bereichen mittels Multi-Mikrofilamentsträngen verbunden ist, und wobei das Filtermaterial Mikrotaschen zur Staubspeicherung beinhaltet.
Patent DE-10354207-B3 (DE)
Title: Verfahren zum Nachweis von pathologisch veränderten Prion-Proteinen (PrPSc) und Kit zur Durchführung des Verfahrens
Inventor: ENGEMANN CLAUDIA
IPC: G01N33/68
Filed: 2003-11-20
Granted: 2005-08-18
Abstract: Die vorliegende Erfindung betrifft ein Verfahren zur Aufbereitung von Körperflüssigkeiten als Voraussetzung für den Nachweis von pathologisch veränderten Prion-Proteinen (PrP·Sc·) in lebenden Organismen sowie einen Kit zur Durchführung des Verfahrens.
Patent ES-2012062-B3 (ES)
Inventor: HAAKE WERNER
IPC: H01H3/14
Filed: 1987-02-20
Granted: 1990-03-01
Abstract: 1. Closing-edge security device with a security strip which comprises an electrical switching arrangement, having a plurality of contact elements (2, 2a) which are arranged in a row one after the other in an elastic flexible tube (1), the contact elements in the condition of rest abutting on one another at contact zones (5) situated at their end faces under the influence of an elastic preload, and being moved away from one another, interrupting contact, when the flexible tube is deformed under the action of an external force, characterised in that a) in the interior of the contact elements (2, 2a) there is arranged an expander cord (12) which urges the individual contact elements (2, 2a) in the axial direction towards one another with their contact zones (5), and b) insulating rings (3, 3a) are arranged between the individual contact elements (2, 2a).
Patent ES-2022240-B3 (ES)
Inventor: REISENWEBER WALTER
IPC: H02K3/38
Filed: 1987-09-07
Granted: 1991-12-01
Abstract: In order to insulate in a simple manner the basically bare rotor shaft region between the one rotor stack end face (21) and the oppositely located commutator end face (51) at its circumference, a sleeve (4) which can be upset (collapsed) axially, is fabricated as a unitized part and is formed preferably integrally at the collar (31) of the insulating end disc (3) covering the rotor stack end face (21), is put on before the commutator (5) is pressed on, and is axially collapsed when the commutator (5) is pressed on.
Patent ES-2025210-B3 (ES)
Inventor: PEDANI GIUSEPPE
IPC: B60S1/24
Filed: 1987-11-24
Granted: 1992-03-16
Abstract: The device is arranged to carry the windscreen-wiper blades into rest positions, beyond their normal end-of-stroke positions, as a result of a rotation of the geared motor unit in the opposite sense. The device comprises two half-cranks (8, 9) articulated together and connected at their opposite ends to the output shaft (20) of the geared motor unit and to a connecting rod (6) for driving the windscreen-wiper, respectively. The two half-cranks (8, 9) consist of two discs defining between them a cavity filled with lubricant.
Patent ES-2019434-B3 (ES)
Inventor: SCHONBORN HANS DIETER
IPC: E01F15/00
Filed: 1988-06-14
Granted: 1991-06-16
Abstract: The separation device consists of a row of interconnected concrete elements which form a separating and/or sliding wall on or between roadways, are designed as horizontal prisms and adjoin one another with front faces which run at an angle of 45 DEG  to the prism length. The concrete elements are in each case directed towards the traffic and the traffic direction, with the end at which the lateral prism surface and front face form an obtuse angle, the front faces and/or base faces are equipped with synthetic elastic, if appropriate knopped, material for the purpose of increasing the mutual connection, and the base faces have at least one transverse, downwardly open groove for drainage and increasing displacement security, whereas there are provided, starting from the front faces, either in the region of the base face and/or the top lateral surface, and symmetrically to the vertical longitudinal mid-plane, slots which are extended conically or at the ends and receive cross-sectionally adapted, at least metal- reinforced connecting bolts, and/or approximately dovetail-shaped recesses for receiving bridging bolts are provided on lateral surfaces facing away from the traffic. <IMAGE>
Patent PL-173546-B3 (PL)
Title: Method of and system for monitoring and controlling absorbed power of an electric load
Inventor: POLOCZEK WINCENTY
IPC: G05F1/14
Filed: 1994-05-09
Abstract: 1. The method of power control and regulation is designed for electric power receivers. It consists of continuous measurement of the receiver power and of noise generated by the operating electric power receiver, as well as of the temperature of selected points of the receiver, that are most exposed to heating. The values of current and/or power consumed by the receiver and of the noise level obtained during the measurements are compared with the pre-set limit values of the power ordered from the electric energy supplier, the allowable current intensity, the allowable temperature of the selected places of the electric receiver and the allowable noise level. The signal increments obtained from such comparison are used to regulate the electric parameters of the follow-up regulation modules with regulating transformers as actuator elements, which supply power to the receiver, as described in patent No. 171 781. Characterized in that: Additionally, the temperatures of the voltage-adjusting transformer and the regulating transformer are constantly measured. The results of these measurements are compared to the pre-defined limit values of the temperatures of both transformers. The signal increments obtained from such comparisons are used to regulate the electric follow-up regulation modules.
Patent HR-PK20170685-B3 (HR)
Inventor: LEVAČIĆ DEJAN
IPC: C11B9/00
Filed: 2017-05-04
Abstract: Dosadašnje kreacije parfema od koprive spravljaju se na način da glavna esencija biljke koprive jest od sintetičkih pripravaka. Ovim tehničkim rješenjem pripravka dobivanja parfema od koprive Ortica gdje je kopriva glavni esencijalni sastojak dobiven prirodnim putem, sušenjem i drobljenjem lišća koprive, čime se dobiva prirodna zelena boja parfema, koja uvijek ovisi o tome na kojem je mjestu ubrana i u kojem vremenskom periodu. Različite lokacije branja koprive pokazale su da uvijek daju drugačiji tonalitet prilikom proizvodnje parfema od svjetlo zelene do zagasito zelene boje.Perfume creations from nettle Ortica have been prepared in the way that the main essence of nettle is made of synthetic preparations. This technical solution of the preparation helps to obtain perfume from nettle Ortica where nettle is the main essential substance obtained naturally, by drying and crunching nettle leaves, which helps to achieve natural green colour of the perfume, always depending on which place and when it was harvested. Different locations of harvesting nettle have shown to always give different tone in perfume production, from light green to dark green.
Patent DE-102004033741-B3 (DE)
Inventor: STAEHLE KURT
IPC: G01M17/007
Filed: 2004-07-13
Granted: 2006-01-19
Abstract: An arm (20) with an uncoupling device (21) may be fastened to the vehicle bodywork. It is attached to an electric motor (40) and prevents rotation of the motor casing. A housing (30) is rotated by the motor and engages a slotted holder plate (10). Clamping members (11-13) may be fastened in different positions on the slotted plate and engage the vehicle steering wheel (50).
Patent DE-102005019879-B3 (DE)
Title: Transport process for baskets through a multistation throughput goods washer has transport rails and catches with a lifting swiveling movement
Inventor: KUPETZ JOACHIM
IPC: A47L15/24
Filed: 2005-04-28
Granted: 2006-06-22
Abstract: A transport process for baskets through a multi-station throughput goods washer comprises transport rails (5,6) with catches (10) driven in the transporting direction (1.1) by a rotating axle (3). A swiveling movement (11) of catches is caused by a forwards (VH) and back wards (RH) lift of the rail around an axle parallel to the transport direction. An independent claim is also included for a machine for the above process.
Patent DE-102005043397-B3 (DE)
Title: Electronic active sensor with nano-pore array, e.g. for selective detection of magnetic fields, has high impedance conductive layer on surface of dielectric and ferrous fluid in nano-pores
Inventor: FINK DIETMAR
IPC: G01N27/22
Filed: 2005-09-08
Granted: 2007-01-11
Abstract: The sensor has a high impedance conductive layer (HS) on a surface of the dielectric (D) and a ferrous fluid (F) in the nano-pores (NP). A small pore diameter ensures that a resistance of the high impedance conductive layer is measurable at the contacts (O, W, V). A characteristic curve follows a differential negative resistance behavior.
Patent DE-102005052000-B3 (DE)
Title: Halbleiterbauelement mit einer Kontaktstruktur auf der Grundlage von Kupfer und Wolfram
Inventor: FROHBERG KAI
IPC: H01L29/417
Filed: 2005-10-31
Granted: 2007-07-05
Abstract: Durch
Bereitstellen von Kontaktpfropfen mit einem unteren Pfropfenbereich,
der auf der Grundlage gut etablierter wolframbasierter Technologien hergestellt
wird, und einem oberen Pfropfenbereich, der ein äußerst leitfähiges Material, etwa Kupfer
oder eine Kupferlegierung, aufweist, kann eine deutliche Verbesserung
der Leitfähigkeit
der Kontaktstruktur erreicht werden. Zu diesem Zweck wird nach dem
Abscheiden einer ersten dielektrischen Schicht des Zwischenschichtstapels
ein Einebnungsprozess ausgeführt,
um damit die Ausbildung der unteren Kontaktpfropfenbereiche auf
der Grundlage von Wolfram zu ermöglichen,
während
nach dem Abscheiden der zweiten dielektrischen Schicht eine entsprechende
kupferbasierte Technologie eingesetzt werden kann, um die oberen
Pfropfenbereiche mit deutlich verbesserter Leitfähigkeit zu bilden.
Patent DE-102005053400-B3 (DE)
Title: Ultrasonic welding head for welding chip to substrate has raised adhesive friction element on welding head with plane friction end surface
Inventor: GOEBL CHRISTIAN
IPC: H01R43/02
Filed: 2005-11-09
Granted: 2007-02-08
Abstract: An ultrasonic welding head (10) for welding a chip (22) to a substrate comprises a raised adhesive friction element (16) on the welding head post (14) that has a planar friction end surface (20) relative to the chip. Preferably the friction end is formed from a ceramic plate of roughness 5-15 mu m that is produced by lapping or etching.
Patent DE-102006009443-B3 (DE)
Inventor: PIETSCH WALTER
IPC: E06B7/14
Filed: 2006-03-01
Granted: 2007-10-31
Abstract: The device has draining components mounted diagonal towards outside and in downward direction at the butt joints of the frame on both sides of the frame of the facade element (2).The drainage components are formed, sealed at frame butt joints at the contact area of the drainage components and are mounted adjacent with the same inclination and same height at the butt joints of the frame.
Patent DE-102006012521-B3 (DE)
Title: Verfahren und Vorrichtung zur Herstellung von Formkörpern, insbesondere Platten, aus lignocellulosehaltigen Fasern
Inventor: STAHL WOLFGANG
IPC: B27N1/00
Filed: 2006-03-18
Granted: 2007-10-18
Abstract: Bei der Herstellung von Formkörpern, insbesondere Platten, aus Lignocellulose haltigen Fasern werden die Fasern aus einem Ausgangsmaterial (2) feucht aufgeschlossen und durch ein Blasrohr (8) einem Trockner (11) zugeführt. Vor dem Trockner (11) wird Wasserdampf (16) von den Fasern abgetrennt. Dazu wird ein Teil (16) des Wasserdampfs von den Fasern durch einen porösen Teilbereich einer Wandung des Blasrohrs (8) abgelassen.
Patent DE-102006024147-B3 (DE)
Title: Elektronisches Modul mit Halbleiterbauteilgehäuse und einem Halbleiterchip und Verfahren zur Herstellung desselben
Inventor: BAUER MICHAEL
IPC: H01L23/498
Filed: 2006-05-22
Granted: 2007-11-29
Abstract: Die Erfindung betrifft ein elektronisches Modul (1) mit Halbleiterbauteilgehäuse (2) und mindestens einem Halbleiterchip (7) und ein Verfahren zur Herstellung desselben. In dem Halbleiterbauteilgehäuse (2) ist der Halbleiterchip (7) auf einem Schaltungsträger (8) angeordnet. Der Halbleiterchip (7) ist über Verbindungselemente (9) mit einer Oberseite (11) des Schaltungsträgers (8) verbunden. Dabei sind der Halbleiterchip (7), die Verbindungselemente (9) und teilweise der Schaltungsträger (8) in eine Kunststoffgehäusemasse (12) eingebettet. Auf der Oberseite (17) des Halbleiterbauteilgehäuses (2) ist eine in Flachleiterbahnen (18) und Kontaktanschlussflächen (19) strukturierte Metallplatte (20) vorgesehen.
Patent DE-102006031899-B3 (DE)
Title: Interior component e.g. seat, surface air conditioning system for motor vehicle, has coating layer that is connected with air conditioning layer such that insertion case is formed, and detector device that is inserted into case
Inventor: STOEWE STEFAN
IPC: B60H1/00
Filed: 2006-07-07
Granted: 2007-06-21
Abstract: The system has an air conditioning layer (25) that extends partially along a surface (5) of a vehicle-interior-surface. A coating layer extends partially along the air conditioning layer. The coating layer is connected with the air conditioning layer such that an insertion case is formed. A detector device is inserted into the case, and a detection layer is formed between the air conditioning layer and the coating layer.
Patent DE-102007017616-B3 (DE)
Title: Gas- und Kühlmitteldüse
Inventor: MEYER DETLEF
IPC: B23K9/16
Filed: 2007-04-12
Granted: 2008-09-25
Abstract: Vorrichtung (1) zum Zuführen von Gas und Kühlmittel in die Prozesszone während des Schweißens, insbesondere während des Laserschweißens, mit mindestens einer Gasdüse (2) mit einem Gasführungskanal (3) und mindestens einer unterhalb der Gasdüse angeordneten Kühlmitteldüse (4) mit einem Kühlmittelführungskanal (5), wobei der Gasführungskanal (3) der Gasdüse (2) so angeordnet ist, dass das Gas stechend der Prozesszone (S) zugeführt wird und die Kühlmitteldüse (4) so angeordnet ist, dass diese in Wärmekontakt mit der Gasdüse (2) steht und eine Kühlung der Gasdüse (2) erfolgt. Die Aufgabe, eine gattungsgemäße Vorrichtung zur Verfügung zu stellen, welche bei hoher Prozesssicherheit ein Schweißen bzw. ein Laserschweißen von kritischen Werkstoffen mit hoher Geschwindigkeit zulässt, wird dadurch gelöst, dass die Kühlmitteldüse (4) eine mit dem Kühlmittelführungskanal (5) verbundene Kühlmittelaustrittsbohrung (7) aufweist, wobei die Kühlmittelaustrittsbohrung in Kühlmittelaustrittsrichtung entgegengesetzt zur Schweißrichtung (A) verläuft und in einer äußeren Nut (8) der Kühlmitteldüse (4) endet.
Patent DE-102009061774-B3 (DE)
Title: Antriebsanordnung mit einem Elektroantrieb mit einer Parksperrenanordnung
Inventor: SCHWEKUTSCH MICHAEL DIPL -ING
IPC: F16H63/38
Filed: 2009-06-02
Granted: 2023-05-11
Abstract: Antriebsanordnung zum Antreiben einer Antriebsachse eines Kraftfahrzeugs, umfassend:einen Elektroantrieb (3) mit einer Längsachse,ein Stirnradgetriebe (28) mit einer Zwischenwelle (5), die vom Elektroantrieb (3) drehend antreibbar ist,ein Differentialgetriebe (30) mit einem Differentialkorb (32) mit einer Drehachse, wobei die Zwischenwelle (5) des Stirnradgetriebes (28) mit dem Differentialkorb (32) zur Übertragung eines Drehmoments antriebsverbunden ist,wobei die Längsachse des Elektroantriebs (3), die Zwischenwelle (5) des Stirnradgetriebes (28) und die Drehachse des Differentialkorbs (32) parallel zueinander angeordnet sind,eine Parksperrenanordnung (2) mit einem elektrisch steuerbaren Aktuator (7) undeinem Sperrmechanismus (6) zum Hemmen oder Freigeben der Zwischenwelle (5), wobei der Sperrmechanismus (6) ein Sperrenrad (20) aufweist, das drehfest mit der Zwischenwelle (5) verbunden ist, sowie ein mit dem Sperrenrad (20) zusammenwirkendes Sperrglied (14), wobei das Sperrglied (14) in eine Sperrstellung überführbar ist, in der das Sperrglied (14) mit dem Sperrenrad (20) formschlüssig verbunden ist, so dass das Sperrenrad (20) an einer Drehbewegung gehindert wird, und in eine Entriegelungsstellung, in der das Sperrenrad (20) gegenüber dem Sperrglied (14) frei drehen kann, wobei der Sperrmechanismus (6) ein vom Aktuator (7) bewegbares Druckelement (10) aufweist, das mit dem Sperrglied (14) zusammenwirkt, um dieses in Richtung zum Sperrenrad (20) zu beaufschlagen oder freizugeben, undeine Führungshülse (24) zur Führung des bewegbaren Druckelements (10) quer zu einer Längsachse der Zwischenwelle (5), wobei das Druckelement (10) gegen die Führungshülse (24) in Bezug auf die Drehachse der Zwischenwelle (5) radial abgestützt ist.