Patent SG-11201407175R-A (SG)
Title: Enhanced affinity t cell receptors and methods for making the same
Inventor: SCHMITT THOMAS M
IPC: A61K39/00
Filed: 2013-05-02
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 7 November 2013 (07.11.2013) WIPOIPCT (10) International Publication Number WO 2013/166321 A1 (51) International Patent Classification: C12N 5/0783 (2010.01) C07K19/00 (2006.01) C12NS/10 (2006.01) A61K35/12 (2006.01) C12N15/867 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/039316 2 May 2013 (02.05.2013) English (30) Priority Data: 61/642,358 3 May 2012 (03.05.2012) English US (71) Applicant: FRED HUTCHINSON CANCER RE­ SEARCH CENTER [US/US]; 1100 Fairview Avenue North, Seattle, Washington 98109 (US). (72) Inventors: SCHMITT, Thomas M.; 4426 1st Avenue Northwest, Seattle, Washington 98107 (US). GREEN- BERG, Philip D.; 6510 82nd Avenue Southeast, Mercer Island, Washington 98040 (US). (74) Agents: SUN, Eileen, S. et al.; Seed Intellectual Property Law Group PLLC, Suite 5400, 701 Fifth Avenue, Seattle, Washington 98104-7064 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) [Continued on next page] (54) Title: ENHANCED AFFINITY T CELL RECEPTORS AND METHODS FOR MAKING THE SAME CJ No Peptide O.OOOluM O.OluM EISSTTIDSSS! luM Day 5 Day 16 o.m u 0,0605 Day 20 6.898 mw 1 ' Q.0837 1.2b. M U.U672 P : '^\"0.21$ V.1ti 0.072 i 0.211 i-H (57) Abstract: The present disclosure provides methods for generating enhanced affinity T cell receptors by agonist selection of O hematopoietic progenitor cells expressing an antigen specific TCRa cultured with stromal cells expressing Delta-like-1 or Delta-like- ^ 4, compositions prepared from such methods, and uses of thereof. r*) WO 2013/166321 A11 lllll llllllll II llllll III lllll lllll lllll III III III lllll lllll lllll llll llll lllll lllllll llll llll Published. — with sequence listing part of description (Rule 5.2(a)) — with international search report (Art. 21(3))