Patent SG-11201408460U-A (SG)
Title: Inhibitors of the mir-15 family of micro-rnas
Inventor: VAN ROOIJ EVA
IPC: C07H21/04
Filed: 2013-06-21
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 December 2013 (27.12.2013) WIPOIPCT (10) International Publication Number WO 2013/192486 A1 (51) International Patent Classification: A61K 48/00 (2006.01) C12N15/11 (2006.01) C07H21/04 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/046960 21 June 2013 (21.06.2013) English (30) Priority Data: 61/662,772 61/780,352 21 June 2012 (21.06.2012) 13 March 2013 (13.03.2013) English US US (71) Applicant: MIRAGEN THERAPEUTICS [US/US]; 6200 Lookout Road, Boulder, Colorado 80301 (US). (72) Inventors: VAN ROOIJ, Eva; c/o Miragen Therapeutics, 6200 Lookout Road, Boulder, CO 80301 (US). DALBY, Christina; c/o Miragen Therapeutics, 6200 Lookout Road, Boulder, Colorado 80301 (US). SETO, Anita; c/o Mira­ gen Therapeutics, 6200 Lookout Road, Boulder, Colorado 80301 (US). (74) Agents: MCLEOD, Bonnie Weiss et al.; Cooley LLP, 1299 Pennsylvania Avenue, N.W., Suite 700, Washington, District of Columbia 20004-2400 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: INHIBITORS OF THE MIR-15 FAMILY OF MICRO-RNAS Cdc.ZSunRNA 00 •t CJ 0\ i-H cn i-H o CJ (57) Abstract: The invention provides chemically modified oligonucleotides capable of inhibiting the expression (e.g., abundance) of miR-15 family miRNAs, including miR-15a, miR-15b, miR-16, miR-195, miR-424, and miR-497. The invention provides in some embodiments, oligonucleotides capable of inhibiting, in a specific fashion, the expression or abundance of each of miR-15a, miR-15b, miR-16, miR-195, miR-424, and miR-497. The invention further provides pharmaceutical compositions comprising the oli­ gonucleotides, and methods of treating patients having conditions or dis­ orders relating to or involving a miR-15 family miRNA, such as a cardiovas­ cular condition. In various embodiments, the oligonucleotides provide ad­ vantages in one or more of potency, efficiency of delivery, target specificity, toxicity, and/or stability. WO 2013/192486 A11 lllll llllllll II llllll III lllll lllll lllll III III III lllll lllll lllll lllll llll llll lllllll llll llll Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))