baber/WOPTO huggingface dataset:
Patent CA-3166772-A1 (CA)
Inventor: ANDRIEN BRUCE
IPC: A61P37/02
Filed: 2015-03-06
Abstract: Herein is described an isolated antibody or antigen-binding fragment thereof, comprising CDRH1 comprising of SEQ ID NO:1, CDRH2 comprising of SEQ ID NO:2, CDRH3 comprising SEQ ID NO:3, CDRL1 comprising SEQ ID NO:4, a light chain CDRL2 comprising SEQ ID NO:5, and CDRL3 comprising SEQ ID NO:6, in which at least one amino acid of is substituted with histidine, wherein the substitution is at an amino acid position selected from the group consisting of position 8 of SEQ ID NO:4, position 10 of SEQ ID NO:4, position 3 of SEQ ID NO:6, position 6 of SEQ ID NO:6; position 2 of SEQ ID NO:1, position 9 of SEQ ID NO:1, position 3 of SEQ ID NO:2, and position 8 of SEQ ID NO:2. Applications related to binding complement component human C5 or inhibiting its cleavage are also described, along with therapeutic uses.
Patent CA-3174537-A1 (CA)
Inventor: STEINBERG BARRETT ETHAN
IPC: C12N15/11
Filed: 2021-03-04
Abstract: Methods and compositions for modulating a target genome are disclosed.
Patent CA-3181004-A1 (CA)
Inventor: SHI WEIYANG
IPC: C12Q1/6869
Filed: 2021-06-02
Abstract: The present application relates to a method for analyzing target nucleic acid from a cell, comprising: 1) providing the following discrete partition: target nucleic acid derived from a single cell and added with an oligonucleotide adapter sequence, and a solid support with at least one oligonucleotide tag attached, wherein each oligonucleotide tag comprises a first chain and a second chain, the first chain comprises a barcode sequence and a hybridization sequence located at the 3' end of the barcode sequence, the second chain comprises a first portion complementary to the hybridization sequence of the first chain and a second portion complementary to the oligonucleotide adapter sequence attached to the target nucleic acid, and the first chain and the second chain form a partially double-stranded structure, or the second chain and the target nucleic acid attached form a partially double-stranded structure; and 2) in the discrete partition, the oligonucleotide tag is linked to the target nucleic acid attached, thereby producing barcoded target nucleic acid.
Patent CA-3181765-A1 (CA)
Inventor: EKIZOGLOU SOFIA
IPC: A61K39/00
Filed: 2021-05-10
Abstract: La présente invention concerne des compositions comprenant plus d'environ 100 mg/ml d'un anticorps anti-IL-33, un tensioactif, de l'arginine et un tampon. L'invention concerne également des procédés de fabrication des compositions et des procédés de traitement d'une maladie chez un sujet.
Patent CA-3182128-A1 (CA)
Inventor: JIN XIA
IPC: C12M1/34
Filed: 2022-11-17
Abstract: The present invention provides a test device for nucleic acid, including a sample treatment chamber, a sample reaction chamber and a test chamber which are disposed from top to bottom successively. The functions of sampling, nucleic acid purification, isothermal amplification and testing result reading by immunochromatography are integrated onto a device to prepare a simple and cute test device for nucleic acid; the device can achieve nucleic acid testing only by two rotations and can ensure that each sampling or reagent adding can reach the target area in a free falling way without any extra drainage facility. The present invention has lower costs, more convenient operation, high detection sensitivity, short time required in nucleic acid testing, and can be used for nucleic acid testing of various samples, such as human and animals.
Patent CA-3182278-A1 (CA)
Inventor: MUNION ROBERT
IPC: C08F222/06
Filed: 2021-06-15
Abstract: L'objet divulgué présentement est relatif à des formulations de compositions de stabilisation d'azote contenant un constituant stabilisateur d'azote et un constituant anhydride d'acide organique conjointement avec un solvant aprotique et un stabilisateur d'amine. Les formulations divulguées ici présentent de nombreuses propriétés bénéfiques telles qu'une solubilité accrue des constituants individuels à des concentrations élevées ainsi qu'une stabilité thermique chimique accrue de la formulation.
Patent CA-3185294-A1 (CA)
Title: System and methods for user interface orchestration and presentation
Inventor: ORTIZ EDISON U
Filed: 2022-12-15
Abstract: There is provided a computer system and method for orchestrating user interface, the method include: obtaining a first data set representative of intercepted data communication messages between a user interface of a user and a merchant hosting server; obtaining a second data set representing an instruction set for loading visual elements on the user interface provided from the merchant hosting server; analyzing the first data set to obtain one or more user-specific characteristics; determining if the user-specific characteristics associated with the user satisfy a trigger condition associated with a current resource offering;  and responsive to a positive determination: injecting, into the instruction set for loading the visual elements on the user interface provided from the merchant hosting server, code corresponding to an interactive visual element corresponding to the current resource offering.
Patent CA-3186737-A1 (CA)
Title: Return of items from security checkpoints
Inventor: CACCIATO RICHARD
IPC: G06Q10/08
Filed: 2021-07-22
Abstract: When a security screen at a security checkpoint identifies a forbidden item carried by a passenger, the passenger may be directed to a checkin station for a retrieval service. At the checkin station, passenger puts item into an envelope, and takes a physical receipt without delaying to enter delivery data. The physical receipt may be preprinted with an accessor code to a database that will give the passenger a tracking code and access to a database record to enter delivery and payment information. The accessor code may be a QR code, bar or machine vision code, an RFID tag that can be scanned by a sensor in a phone, a URL with a unique code to be typed, etc. Retrieval service may permit passenger to enter delivery data once the time constraint is relieved. Retrieval service may use a commercial delivery service such as UPS, FedEx, DHL, or a government Postal Service.
Patent CA-3186826-A1 (CA)
Title: Compositions and methods for the treatment of eye diseases
Inventor: SHI ZHONGDONG
IPC: A61K38/17
Filed: 2021-07-20
Abstract: Provided are compositions for treating or preventing Retinitis Pigmentosa. The compositions comprise a first polynucleotide and a second polynucleotide. The compositions may further comprise a third sequence and a fourth sequence. Also provided are the recombinant adeno-associated virus particles, systems, methods, and kits for practicing or using the same.
Patent CA-3189182-A1 (CA)
Inventor: CORBETT MICHAEL J
IPC: G05D1/00
Filed: 2021-08-09
Abstract: Testing operational characteristics of a remote control device (32) associated with a materials handling vehicle can include waiting for receipt of a first input indicative that a first button of the remote control device (32) has been pressed, wherein the first button comprises a travel button (197A) of the remote control device (32). The testing may further comprise waiting for receipt, subsequent to receiving the first input, of a second input indicative that at least a second button (197B-C) of the remote control device (32) has been pressed, wherein the second button (197B-C) relates to a first auxiliary vehicle function. The testing still further comprises determining whether or not a predetermined button pressing sequence is successful based at least in part on receiving or not receiving the first and second inputs; and optionally driving a display on the vehicle to provide a visual indication that the button pressing sequence is successful or not successful based on the determination.
Patent CA-3190755-A1 (CA)
Title: Molecules multifonctionnelles se liant a la calreticuline et utilisations associees
Inventor: LOEW ANDREAS
IPC: A61P35/00
Filed: 2021-08-25
Abstract: L'invention concerne des molécules multifonctionnelles qui comprennent i) un domaine de liaison à l'antigène qui se lie à une protéine calréticuline ; et un, deux ou tous les éléments suivants : ii) un anticorps "immune cell engager" (par ex., choisi parmi un anticorps "NK cell engager", un anticorps "T cell engager, un anticorps "B cell engager", un anticorps "macrophage cell engager") ; iii) une molécule cytokinique ; et/ou (iv) une fraction de modification stromale. L'invention concerne également des acides nucléiques codant pour ceux-ci, des procédés de production des molécules précitées et des méthodes de traitement d'un cancer à l'aide desdites molécules.
Patent CA-3192154-A1 (CA)
Title: Systeme de protection de reservoir d'eau
Inventor: PETRICH CHRISTIAN
IPC: E02B1/00
Filed: 2021-10-25
Abstract: La présente invention concerne un système passif de protection (10) de réservoir d'eau pour la protection d'une structure (2) de réservoir d'eau contre des forces statiques générées et/ou transférées par de la glace (4) flottant sur un corps d'eau (3) d'un réservoir d'eau (1). Le système passif de protection (10) de réservoir d'eau comprend un élément de jupe (21), un élément flottant (11) fixé à l'élément de jupe (21) ou intégré à ce dernier, ainsi qu'un système d'ancrage (50) destiné à fixer l'élément de jupe (21) à une distance (D) de la structure (2) de réservoir d'eau.
Patent CA-3192485-A1 (CA)
Title: Systems and methods for automated vehicle fleet management according to dynamic pedagogical behavior reinforcement
Inventor: KUEHNLE ANDREAS U
IPC: G06Q10/06
Filed: 2023-03-09
Abstract: Vehicle fleet management includes processing event-based data corresponding to detected events to generate event data sets that include: at least video corresponding to the event and data identifying an event-type for the event. One or more pedagogical event pairs are identified, each of which includes a first event data set reflecting a "good" response to an event-type and a second event data set reflecting a "bad" response to the event-type. At least one cluster of drivers having similar occurrence rates for the event-type is identified. One or more training lessons are generated for the cluster based on the event type, which training lessons include at least the video of the first event data set and the video of the second event data set. The training lessons are administered to a driver of the cluster via a computing device. The autonomous control of one or more vehicle systems is instituted based on the administered training lessons.
Patent CA-3193139-A1 (CA)
Inventor: SACHS ADAM
IPC: H04N13/239
Filed: 2015-05-05
Abstract: A system for use in surgery includes a central body, a visualization system operably connected to the central body, a video rendering system, a head-mounted display for displaying images from the video rendering system, a sensor system, and a robotic device operably connected to the central body. The visualization system includes at least one camera and a pan system and/or a tilt system. The sensor system tracks the position and/or orientation in space of the head-mounted display relative to a reference point. The pan system and/or the tilt system are configured to adjust the field of view of the camera in response to information from the sensor system about changes in at least one of position and orientation in space of the head-mounted display relative to the reference point.
Patent CA-3194322-A1 (CA)
Title: Identification d'utilisateur avec reponse melangee a partir d'un service d'identification a double couche
Inventor: CHAN SIK SUEN
IPC: G06F21/32
Filed: 2021-09-30
Abstract: Identification d'utilisateur avec une réponse mélangée à partir d'un service d'identification à double couche. Dans un mode de réalisation, un serveur comprend un processeur électronique configuré pour détecter une demande d'accès par un utilisateur d'un dispositif d'interface utilisateur, récupérer une pluralité d'enregistrements de profils d'entrée à partir d'un référentiel d'enregistrements de profils d'entrée, réaliser une identification de l'utilisateur avec un ou plusieurs modèles biométriques passifs et la pluralité d'enregistrements de profils d'entrée qui sont récupérés, générer une réponse d'identification et une demande d'identification supplémentaire sur la base d'un résultat de l'identification de l'utilisateur, commander l'interface de communication pour transmettre la demande d'identification supplémentaire au second serveur par l'intermédiaire du réseau, recevoir une seconde réponse d'identification provenant du second serveur, et générer une réponse mélangée en modifiant une ou plusieurs caractéristiques de la réponse d'identification avec la seconde réponse d'identification, la réponse mélangée indiquant l'identification de l'utilisateur.
Patent CA-3194411-A1 (CA)
Title: Monitoring and control of thermal sanitization in automated cleaning machines
Inventor: HAN ELIZABETH MINHEE
IPC: A47L15/42
Filed: 2021-03-05
Abstract: Systems and/or methods for the monitoring and/or control of thermal sanitization in automated cleaning machines are described. A cleaning machine controller may predict a number of heat unit equivalents that will be delivered during a cleaning process based on a sump temperature difference (i.e., a change in the temperature of the cleaning solution in the sump) experienced at or near the beginning of the cleaning process. One or more cleaning process parameters may be adjusted and/or controlled based on the sump temperature difference in order to ensure that a target number of heat unit equivalents are delivered in order to achieve thermal sanitization of the wares subjected to the cleaning process.
Patent CA-3195380-A1 (CA)
Inventor: WELSH FRASER
IPC: C07K16/22
Filed: 2021-09-27
Abstract: L'invention concerne de nouveaux procédés et schémas posologiques destinés à être utilisés dans le traitement ou la prévention de la douleur, la molécule de liaison comprenant un domaine antagoniste de NGF et un domaine antagoniste de TNF?, le domaine antagoniste de NGF étant un anticorps anti-NGF ou un fragment de liaison à l'antigène de celui-ci et le domaine antagoniste de TNFa comprenant un fragment de liaison à TNF? soluble de TNFR.
Patent CA-3195537-A1 (CA)
Title: Porous assemblies and related methods of fabrication and use
Inventor: MOHANRAM ARAVIND
IPC: B01J20/32
Filed: 2021-10-14
Abstract: The present disclosure provides advantageous porous assemblies, and improved systems and methods for utilizing and/or fabricating the porous assemblies. More particularly, the present disclosure provides porous assemblies fabricated at least in part by additive manufacturing (e.g., via a 3D printing process, such as, for example, via an electron beam additive manufacturing process, via a laser additive manufacturing technology, via an inkjet or a binder jet additive manufacturing process, etc.), the porous assemblies including a porous monolith support structure or substrate for a sensitive or active layer of a multi-layer application (e.g., for sensitive/active layers in fuel cell/electrolyzer/battery and other multi- layer applications).
Patent CA-3196142-A1 (CA)
Title: Systeme intelligent pour adapter et appliquer des procedes
Inventor: KERWIN KEVIN RICHARD
IPC: G06Q10/10
Filed: 2021-08-25
Abstract: Un procédé d'optimisation d'un processus comprend la sélection d'un processus nominal et la fourniture d'instructions pour une étape du processus nominal à un utilisateur, l'analyse d'au moins une alimentation de caméra à l'aide d'un réseau neuronal et la détermination d'une action effectuée par l'utilisateur et/ou d'une action prévue pour être effectuée par l'utilisateur, l'adaptation du processus nominal en réponse à l'action effectuée par l'utilisateur variant à partir des instructions fournies, et la fourniture d'instructions pour une étape suivante du processus nominal adapté. Les instructions pour une étape suivante s'écartent du processus nominal sur la base de l'action déterminée effectuée par l'utilisateur. Réitérer les étapes d'analyse de la ou des alimentations de caméra, d'adaptation du processus nominal, et de fourniture d'instructions pour une étape suivante du procédé adapté jusqu'à ce que le processus soit achevé.
Patent CA-3196340-A1 (CA)
Title: Rotor de debroussailleuse
Inventor: D'AMOURS LUC
IPC: A01G3/08
Filed: 2021-11-04
Abstract: La présente invention concerne un rotor de débroussailleuse qui comprend des ensembles dent coupante agencés de manière séquentielle le long d'un axe longitudinal du rotor de débroussailleuse, et décalés de manière azimutale pour former des spirales entrelacées d'ensembles dent coupante. Les ensembles dent coupante de pistes immédiatement adjacentes sont agencés pour ménager un intervalle longitudinal entre eux, et des lames de séparation sont disposées à l'intérieur dudit intervalle longitudinal de chaque côté de chaque piste comprenant l'un des ensembles dent coupante. Elles forment un peigne pour séparer du matériau entrant vers un centre de la dent correspondante des dents coupantes et à l'opposé de bords latéraux de celle-ci. L'espace avant avant la partie centrale des dents coupantes est ainsi libre, exempt d'un dispositif protecteur. Une plaque d'usure peut être utilisée dans la base de maintien des ensembles dent coupante sous chaque dent coupante.
Patent CA-3197245-A1 (CA)
Title: Compositions and methods of identifying tumor specific neoantigens
Inventor: HACOHEN NIR
IPC: C12Q1/6886
Filed: 2011-05-16
Abstract: The present invention related to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. Specifically, the invention provides a method of identifying tumor specific neoantigens that alone or in combination with other tumor-associated peptides serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor responses.
Patent CA-3197769-A1 (CA)
Inventor: HUH DONGUEN
IPC: C12M1/04
Filed: 2021-12-06
Abstract: The disclosed subject matter provides techniques for culturing organoids or cells. A device for culturing organoids can include an access port configured to receive a solution, a loading chamber, wherein the access port is located in the loading chamber, and a plurality of culture chambers, wherein the culture chambers are radiated from the loading chamber so that the solution injected into the loading chamber through the access port is distributed into the plurality of culture chambers, wherein the plurality of culture chambers are open to an external environment and comprises a protruding edge at an opening of the plurality of culture chambers.
Patent CA-3197796-A1 (CA)
Inventor: BISSET STEPHEN
IPC: E21B23/03
Filed: 2021-11-11
Abstract: La présente invention concerne un mandrin à poches latérales, destiné à être utilisé dans un système d'ascension par poussée de gaz, qui est conçu pour permettre l'échange des poches de soupape. Le mandrin à poches latérales possède un corps central, un récepteur qui est décalé latéralement par rapport au corps central, et une poche de soupape qui est fixée amovible au récepteur. La poche de soupape peut être conçue pour un raccordement fileté avec le récepteur pour permettre l'échange facilité de poches de soupape modulaires au niveau du récepteur. Le gaz émanant de la poche de soupape peut être transporté vers le corps central du mandrin à poches latérales à travers une ou plusieurs conduites de gaz externes ou un ou plusieurs passages d'injection de gaz internes.
Patent CA-3201268-A1 (CA)
Title: Processes to improve catalytic metal accountability in hydroformylation processes
Inventor: BRAMMER MICHAEL A
IPC: C07C45/50
Filed: 2021-11-18
Abstract: Embodiments of the present invention are directed to processes to improve rhodium accountability in continuous liquid recycle hydroformylation processes. In some embodiments, a process comprises contacting in a reaction zone reactants comprising C7-C20 olefins, hydrogen, and carbon monoxide in the presence of a catalyst comprising rhodium and an organomonophosphite ligand to form a reaction fluid, wherein the feed rate of olefins to the reaction zone is greater than 100 kilograms/hour; providing the reaction fluid to a strip gas vaporizer to produce a product stream and a vaporizer tails stream; measuring the C7-C20 olefin content in the vaporizer tails stream; and adding a C7-C20 olefins stream comprising at least 50 weight percent C7-C20 olefins to the vaporizer tails stream to maintain the C7-C20 content in vaporizer tails stream above 2 percent by weight.
Patent CA-3204237-A1 (CA)
Inventor: ZHANG SHUMING
IPC: F24F1/42
Filed: 2021-12-30
Abstract: Provided is a water level control method for an air conditioner. The air conditioner comprises a first fan, a condenser, a compressor, a water tank, a water agitation wheel and a water agitation electric motor, wherein the first fan is configured to perform heat dissipation on the condenser and the compressor, and the water agitation electric motor is configured to drive the water agitation wheel to rotate, so as to spray condensed water in the water tank to the condenser. The water level control method for an air conditioner comprises: determining whether the water level of condensed water reaches a first preset water level; and if the water level of the condensed water reaches the first preset water level, controlling a first fan to run at the lowest rotation speed and controlling a water agitation electric motor to run at the highest rotation speed, detecting the temperature of a condenser, and controlling the running frequency of a compressor according to the temperature of the condenser.
Patent CA-3205595-A1 (CA)
Inventor: OH JEONG WOO
IPC: H01M10/0567
Filed: 2022-09-08
Abstract: La présente invention concerne une batterie secondaire au lithium. Spécifiquement, la batterie secondaire au lithium comprend : une cathode comprenant un matériau actif de cathode ; une anode comprenant un matériau actif d'anode ; un séparateur interposé entre la cathode et l'anode ; et un électrolyte non aqueux pour une batterie secondaire au lithium, l'électrolyte non aqueux pour une batterie secondaire au lithium comprenant un sel de lithium, un solvant organique non aqueux et un composé représenté par la formule chimique 1. Par conséquent, les performances globales de la batterie peuvent être améliorées.
Patent CA-3206228-A1 (CA)
Inventor: SEN GUPTA ANIRBAN
IPC: A61K47/69
Filed: 2022-02-09
Abstract: A nanoparticle and/or microparticle construct for therapeutic applications includes a plurality of targeting moieties that bind to target molecules of a cell, tissue, and/or disease site in a subject, phosphatidylserine phospholipids, and releasable cloaking agents configured to mask the phosphatidylserine phospholipids prior to binding of the target moieties to the target molecules and be released from the construct to expose the phosphatidylserine phospholipids upon binding of the target moieties to the target molecules.
Patent CA-3207282-A1 (CA)
Inventor: SHARP MATTHEW J
IPC: A61K47/10
Filed: 2022-02-14
Abstract: L'invention concerne des formulations de promédicaments d'abiratérone à libération prolongée, des procédés, et des kits pour une administration parentérale à un sujet ayant un trouble bénin ou malin dépendant de l'hormone sexuelle tel que le cancer de la prostate, un cancer entraîné par un récepteur d'androgène, un syndrome dû à un excès d'androgènes et/ou un syndrome dû à un excès de glucocorticoïdes tel que l'hypercortisolémie.
Patent CA-3207398-A1 (CA)
Title: Pressurized soap dispenser and method
Inventor: MAHAFFEY CLEARY E
IPC: A47K5/12
Filed: 2021-02-08
Abstract: A dispenser for dispensing a metered dose of foam or liquid from a reservoir includes means for applying gas pressure either directly or indirectly to a liquid contained in the reservoir for dispensing a liquid or foam through a nozzle. Instead of using a direct pump, the dispenser uses gas pressure inside the dispenser that pushes the liquid out of the reservoir without coming into contact with the reservoir. The dispenser can include a battery operated gas pressure pump and a sensor that senses pressure within the dispenser. In one aspect, an actuator can open a valve for dispensing metered doses of a liquid or foam.