baber/WOPTO huggingface dataset:
Patent GB-2579253-A (GB)
Title: Antibacterial antisense agents
Inventor: MARTIN QUIBELL
IPC: C12N15/113
Filed: 2018-11-28
Abstract: Improved antisense oligonucleotide agents of formula (I) are disclosed for the treatment of pathogenic gram-negative bacterial infections. The said agents utilise an antibiotic-assisted translocation (AAT) platform to improve influx into bacterial cells through enhanced permeability, providing improved intracellular exposure of the antisense agent and superior treatment of the infection. The said agent takes the form of an acyl fragment of an N-acylmuramic acid or 1,6-anhydro-N-acylmuramic acid (SUGAR) which is conjugated to said oligonucleotide (ANTISENSE) via a linker as defined therein and L2, R1, R2, R3, R4, R5, R6 are each as defined therein and m is 0 or 1, n is 0-4, p is 0 or 1 and q is 0 or 1 or any pharmaceutically acceptable salt thereof.
Patent GB-2585020-A (GB)
Title: Apparatus and method
Inventor: PETER THOMPSON
IPC: B61L25/06
Filed: 2019-06-25
Abstract: A signalling device 100 is adapted to be fitted to a rail system. The device comprises a housing 102, and a switching member 122, which is to be acted on by a moving part of a points system and give a resulting signal. An indicator receives the signal and indicates to workers the state of the points. The housing may be adapted to be fitted between the stock rail and the moving rail. The switching member may be a biased lever. The housing 102 may be secured in place magnetically, and include a cam track with associated sliding plate to allow a user to remove the magnetic attachment. The device may be of particular use during maintenance of rail tracks, to provide workers an indication of the state of the points and avoid rail vehicles being moved the wrong way over the points risking derailment.
Patent GB-2588576-A (GB)
Title: Use of cannabinoids in the treatment of dyskinesia associated with Parkinson's disease
Inventor: BENJAMIN WHALLEY
IPC: A61P25/16
Filed: 2019-08-27
Abstract: Tetrahydrocannabivarin (THCV) for use in the treatment of dyskinesia associated with Parkinson’s disease is provided. Preferably the dose of THCV is between 0.1 and 1000mg/kg day. The THCV may be botanically derived highly purified THCV or may be synthetic THCV.
Patent GB-2574561-A (GB)
Title: Engineering CRISPR CAS9 immune stealth
Inventor: PRASHANT MALI
IPC: C12N15/09
Filed: 2018-03-13
Abstract: Described herein are methods of avoiding an immune response in a subject being administered a regimen requiring Cas9 in order to optimize and broaden the application of CRIPSR based therapeutics comprising administering immune orthogonal Cas9. Also described herein are methods to modify a Cas9 protein by swapping highly immunogenic peptides or amino acids with less immunogenic counterparts. These methods are particularly useful to enable the application of Cas9 arsenal for repeat treatments. Further provided are Cas9 proteins modified to reduce immunogenicity.
Patent GB-2588942-A (GB)
Title: Sputter deposition
Inventor: MICHAEL EDWARD RENDALL
IPC: C23C14/56
Filed: 2019-11-15
Abstract: A sputter deposition apparatus comprising a plasma generation arrangement to provide plasma for sputter deposition of target material 102 within a sputter deposition zone 112, a conveyor system 114, 118 for conveying a substrate through the sputter deposition zone in a conveyance direction D, and one or more target support assemblies 108 to support one or more targets in the sputter deposition zone so as to provide for sputter deposition of the target material on the substrate utilising the plasma such that as the substrate is conveyed through the sputter deposition zone in use there is deposited a first stripe on the substrate and a second stripe on the substrate wherein the first stripe comprises at least one of a different density of the target material or a different composition of the target material than the second stripe. Ideally, the conveyor system comprises rollers. Ideally, the apparatus comprises a first target support assembly supporting a first target 102a and a second target support assembly supporting a second target 102b wherein the assemblies are positioned such that a gap 128 exists between them. The apparatus may further comprise confining magnets 124, an antenna 122 and target magnets (126; fig 3)
Patent GB-2581727-A (GB)
Title: Fast locate using imitation reads on tape drives
Inventor: ATSUSHI ABE
IPC: G06F12/00
Filed: 2018-11-06
Abstract: A computer-implemented method, according to one embodiment, includes: receiving a read request for data stored on a magnetic tape, determining whether a copy of a portion of the requested data is located in a cache, instructing a tape drive to access portions of the requested data determined to not be located in the cache, for each of the portions of the requested data that are not located in the cache, determine whether performing a locate command or performing a read command a plurality of times will retrieve the portions of the requested data in a shorter amount of time, issuing the command determined to retrieve the portions of the requested data in the shorter amount of time, combining the portions of the requested data that are not located in the cache with the portion of the requested data located in the cache, and satisfying the read request.
Patent GB-2594958-A (GB)
Title: Zone ventilation arrangement
Inventor: EMANUELE CACCIAGLIA
IPC: F02C7/25
Filed: 2020-05-13
Abstract: A gas turbine engine comprising an interior zone 104 defined between a fairing 50 and a casing 52, wherein the gas turbine engine further comprises a zone ventilation arrangement comprising an inlet 102 through the fairing providing fluid communication between an area outside the fairing and the interior zone. There is an outlet 108 in fluid communication with the interior zone. There is an air amplifier 106 disposed within the interior zone. The air amplifier may be a coanda effect air amplifier or a fan type air amplifier. The air amplifier may be positioned or oriented to direct an air flow over a component of control hardware within the zone; the control hardware may be a valve, an actuator, or a component of an electric, fuel or oil system of an aircraft. The air amplifier may be powered by an air flow from the bypass duct (22, fig 1) or by a compressed air flow from a source of compressed air. The source of compressed air may be from a compressor (14, fig 1). There may be a valve 116 to control the flow of compressed air into the air amplifier.
Patent GB-2583223-A (GB)
Title: Device for supplying heating and hot water
Inventor: SU DAE PARK
IPC: F24D19/10
Filed: 2018-12-24
Abstract: The purpose of the present invention is to provide a device for supplying heating and hot water, which is capable of preventing discharge of high-temperature warm water during the initial stage of warm-water usage, and which is capable of quickly adjusting the temperature of discharged warm water to a target warm-water temperature set by the user. A device for supplying heating and hot water, for the purpose of implementing the same, comprises: a first heat exchanger connected in parallel to a heating consumer so as to generate warm water through heat exchange with a heat medium supplied from a heat source; a second heat exchanger connected in series to the first heat exchanger (110) such that directly-supplied water is preheated by using the heat medium that has passed through the first heat exchanger, and the same then flows to the first heat exchanger; a mixing valve for mixing warm water discharged from the first heat exchanger with the directly-supplied water; and a controller for adjusting the amount of opening of the mixing valve.
Patent GB-2597055-A (GB)
Title: Dynamic context-specific input device and method
Inventor: ERIAND JOCA
IPC: G06F3/0489
Filed: 2020-07-02
Abstract: Manual input device 100, e.g. virtual keyboard, switches inputs to remote processing devices dynamically and context-specifically. A processor of manual‑input‑device 100: detects, from a remote processing device, a first context, and generates a first behaviour mapping based on the first context; detects, from a remote processing device, a second context, and generates a second behaviour mapping based on the second context; the first and second mappings comprise respective mappings of behaviours to corresponding grid locations, the behaviours having behaviour indicators 114, 130. Input-device 100 comprises a touch-screen displaying the behaviour indicators according to grid locations of corresponding behaviours; the touchscreen display receives inputs from a user at physical locations on the touchscreen display, said inputs comprising interactions with indicators 114, 130. A first behaviour mapping can have indicators 114 providing convenient virtual keyboard shortcuts in the first context of an operating system and immutable indicators 130 for crucial operability of the first context. It also comprises vacant grid locations 132 for customisable behaviours. Navigational behaviours 134 allow selection of mappings for a different context, e.g. photo editing or video editing software.
Patent GB-2588519-A (GB)
Title: Hydrostatic pressure turbines and turbine runners therefor
Inventor: ON HOTER-ISHAY
IPC: F03B17/06
Filed: 2020-09-28
Abstract: A water turbine blade 400 has an angle of attack below 35 degrees, and has a short length relative to its span, such that the ratio of the blade axial length projected onto a plane parallel to the axial direction 404, defined as LEE, divided by the blade span A is greater than 0.75. It is said that this produces hydrostatic pressure turbine runners which exploit the hydrostatic pressure of a flowing fluid, rather than kinetic energy from the flow. It is claimed that such a design allows the Betz’ law limit to be exceeded, allowing a conversion efficiency in excess of 66 percent.
Patent GB-2588557-A (GB)
Title: MEMS transducer system and associated methods
Inventor: JEAN PIERRE LASSEUGUETTE
IPC: H04R29/00
Filed: 2017-10-11
Abstract: A system comprises: a MEMS capacitive transducer 112 with a first capacitive plate coupled to a first node and a second capacitive plate coupled to a second node; biasing circuitry 116 coupled to the first node to provide a biasing voltage to the first capacitive plate; output circuitry 124, 128 coupled to the second node; and capacitive circuitry coupled to the first node comprising a charge amplifier 140 arranged in a feedback loop, the feedback loop comprising a first capacitor 142 coupled to an output of the charge amplifier, such that an effective capacitance of the first capacitor is increased based on a gain of the charge amplifier. The first capacitor and the inverting input of the amplifier are coupled to the first node. The non-inverting input is connected to ground. Bypass circuitry with first and second switches 148, 150 is arranged around the charge amplifier. The system may be in a device such as a mobile telephone or portable device.
Patent GB-2605608-A (GB)
Title: Vehicle control apparatus and method
Inventor: JAMES STEPHEN CRAWLEY
IPC: B60W50/14
Filed: 2021-04-06
Abstract: A suspension adjustment apparatus 11 for controlling the suspension height of a vehicle and a method of operating a suspension adjustment apparatus 11. The suspension adjustment apparatus 11 includes a levelling valve 12 and at least one suspension actuator 14. An output value associated with the levelling valve 12 is used to determine whether the suspension height of the vehicle exceeds a threshold height. If the suspension height of the vehicle exceeds the threshold height, a response is triggered, wherein the response includes operating an indicator 22 to provide a warning indication to a user. Optionally, the vehicle comprises a brake system wherein the response includes controlling the brake system to apply one or more of the brakes.
Patent GB-2594174-A (GB)
Title: Fluid substitution method for T2 distributions of reservoir rocks
Inventor: BAOYAN LI
IPC: G01V3/32
Filed: 2019-11-06
Abstract: A method for transforming an earth formation and/or production equipment based on correcting nuclear magnetic resonance (NMR) data to account for partially water-saturated rock includes: receiving NMR logging data having echo-trains for an earth formation; inverting the echo-trains to provide transverse relaxation time constant (T2) distributions for various components of fluid in the earth formation; substituting a T2 distribution for mobile water of fully water-saturated rock for a T2 distribution for mobile water of partially water-saturated rock based on values of the mobile water T2 distribution of partially water-saturated rock and a total porosity constraint; summing the T2 distribution for mobile water of fully water-saturated rock and a T2 distribution for an immobile water component of the fluid to provide a T2 distribution for fully water-saturated rock; and transforming the earth formation and/or the production equipment based on a parameter derived from the T2 distribution for fully water-saturated rock.
Patent GB-2597035-A (GB)
Title: Determination of temperature and temperature profile in pipeline or a wellbore
Inventor: MORTEN KVERNVOLD
IPC: G01K11/24
Filed: 2020-05-08
Abstract: The temperature in a containment region of a structure, e.g. a well, which comprises at least one tubular, e.g. casing and/or tubing, the containment region containing gas, can be determined in various methods, apparatus, and computer device. In various embodiments, an acoustic pulse is produced and at least one acoustic wave travels in the containment region between reference locations in response to the generated pulse; at least one sensor is used to detect the acoustic wave; at least one travel time of the acoustic wave between the reference locations is determined; at least one acoustic velocity for an interval based on the travel time taken between the reference locations is obtained; and the acoustic velocity and an equation of state model is used to determine the temperature.
Patent GB-2605503-A (GB)
Title: Apparatus for charging a robotic load handling device
Inventor: CHRISTOPHER STAREY
IPC: B65G1/137
Filed: 2022-02-11
Abstract: A charge station for a load handling device on a grid structure comprising a plurality of grid members arranged in a grid pattern. The charge station comprises a support structure comprising a base 150 and at least one carriage 135. The charge station further comprises at least one charge head assembly 152 for coupling to a charge receiving head of the robotic load handling device, the at least one charge head assembly 152 being resiliently mounted to the at least one carriage 135 such that the at least one charge head assembly 152 extends outwardly from the base 150 and is moveable in a vertical direction relative to the at least one carriage 135. The at least one carriage 135 is rotatably mounted to the base 150 about a vertical axis extending through the base such that the at least one charge head assembly 152 is rotatable about the vertical axis from a first position to a second position. There may be first and second carriages comprising first and second charge head assemblies. The charge head units may comprise a plurality of profiled sections. A storage system comprising a grid including a charge station is disclosed.
Patent GB-2600073-A (GB)
Title: Image generation using one or more neural networks
Inventor: MING-YU LIU
IPC: G06T11/00
Filed: 2020-09-25
Abstract: Apparatuses, systems, and techniques are presented to generate or manipulate digital images. In at least one embodiment, a network is trained to generate modified images including user-selected features.
Patent GB-2607155-A (GB)
Title: Photonic device with fiducial marks for alignment of an optical component
Inventor: ANDREW MCKEE
IPC: G02B6/42
Filed: 2022-03-04
Abstract: A photonic device 600 formed by: a waveguide 104 defined by its etch, an etched facet (108, 110) defined by its etch, an optical coupling region 114, and a fiducial mark 640. The fiducial mark has a first portion (642, 644) defined by at least a part of the waveguide etch and a second portion 646 defined by at least a part of the facet etch. The waveguide and first portion of the mark may be formed with a first etch depth. The second portion of the mark and the optical coupling region of a structure may be formed with a second etch depth. The first portion may comprise an elongate shape that extends parallel to the waveguide’s propagation direction. The second portion may comprise an elongate shape that extends orthogonally to the etch depth and with respect to the waveguide’s propagation direction. The waveguide may be a ridge or buried heterostructure waveguide. First and second portions of the fiducial mark may be an L or plus pattern. First and second photonic devices may be aligned by their marks and comprise photonic integrated circuits. First and second fiducial protective masks may intercept first and second parts of the waveguide etch.
Patent GB-2603407-A (GB)
Title: Battery charging device for charging a deeply discharged battery, and battery charging system and method
Inventor: JAMES P MCBRIDE
IPC: H02J7/00
Filed: 2020-10-07
Abstract: Provided is a method of charging a deeply discharged battery using a battery charging device, the method including measuring the output voltage of the deeply discharged battery using the battery charging device, and if the output voltage is at or near zero (0) volts, charging the deeply discharged battery using the battery charging device in a forced mode.
Patent GB-2618326-A (GB)
Title: Electronic device for use with an audio device
Inventor: RICHARD SYKES
IPC: G10L19/008
Filed: 2022-05-02
Abstract: An audio device 160 receives an analogue audio signal 165 from a microphone and generates a digital location signal based on information from a sensor 130 and combines the two into a single analogue output signal 155. The digital location signal (eg.orientation or geographic position) is modulated 140 into a high frequency analogue signal. The embedded location signal is used in virtual reality 3D audio or spatial convolution reverberation.
Patent GB-2610936-A (GB)
Title: Experimental device and method for marine liquid level measurement and ship balance control
Inventor: LEI ZHANG
IPC: G09B9/06
Filed: 2021-03-05
Abstract: Disclosed are an experimental device and method for marine liquid level measurement and ship balance control. The experimental device comprises a water inlet pump (1), a liquid level sensor (2), a left-side transverse compartment (3), a water pipe (4), an electromagnetic valve (5), a ballast compartment body (6), a right-side transverse compartment (7), a water outlet pump (8), a simulation water tank (9), and ballast compartments (10), wherein twelve ballast compartments (10) are provided and include a first to a twelfth ballast compartment (10); the ballast compartments (10) are symmetrically distributed on two sides on the whole; the first and second ballast compartments (10) are device heeling adjustment main compartments, and are designed to be 600 mm in length and 450 mm in width; the third and fourth ballast compartments (10) are device trim adjustment main compartments, and are 600 mm in length and 300 mm in width; and the other eight ballast compartments (10) are fine adjustment compartments, and are designed to be equal in area, with the area of the main compartment being greater than that of the fine adjustment compartment. The present invention provides an experimental device which can simulate actual ship ballast compartments, and a valve control method therefor, thereby achieving the external allocation of ballast water and reducing the balance adjustment time.
Patent GB-2608756-A (GB)
Title: Intrusion detection algorithm with reduced tuning requirement
Inventor: CARY R MURPHY
IPC: G08B13/12
Filed: 2022-10-10
Abstract: An optical fibre 1 is monitored for an intrusion event where reflected optical signals are divided into streams S1-SN each associated with a respective location of the optical fibre 1 along a fence 2. Blocks of the streams 14 are selected, each containing a plurality of streams, and these streams are collated, for example by averaging 15, to create a single stream to which an algorithm 10 is applied to create coefficients which are compared with a threshold value 11 to generate an output 12 indicative of disturbance of the fibre by an intrusion event. Each block representative of a length of the fibre 1 is thus treated as a zone, and the detection algorithm is applied to each. This creates a Distributed Acoustic Sensor (DAS) system that does not require unique calibration or tuning as each zone is independently monitored. Applying the above zone principles and algorithms to a DAS system also provides a high level of nuisance alarm and false alarm rejection.
Patent GB-2615912-A (GB)
Title: Transliteration based data augmentation for training multilingual ASR acoustic models in low resource settings
Inventor: SAMUEL THOMAS
IPC: G10L15/00
Filed: 2021-10-15
Abstract: A computer-implemented method of building a multilingual acoustic model for automatic speech recognition in a low resource setting includes training a multilingual network on a set of training languages with an original transcribed training data to create a baseline multilingual acoustic model. Transliteration of transcribed training data is performed by processing through the multilingual network a plurality of multilingual data types from the set of languages, and outputting a pool of transliterated data. A filtering metric is applied to the pool of transliterated data output to select one or more portions of the transliterated data for retraining of the acoustic model. Data augmentation is performed by adding one or more selected portions of the output transliterated data back to the original transcribed training data to update training data. The training of a new multilingual acoustic model through the multilingual network is performed using the updated training data.
Patent GB-2615260-A (GB)
Title: Antimicrobial and/or antiviral nanoparticles
Inventor: Reza Saberi Moghaddam
IPC: C23C14/08
Filed: 2021-10-21
Abstract: A substrate having an antimicrobial and/or antiviral, ferroelectric nanoparticle covalently bonded thereto, wherein the nanoparticle comprises a metal and a dopant.
Patent GB-2616539-A (GB)
Title: A non-toxic cas9 enzyme and application thereof
Inventor: Christopher Hackley
IPC: C12N15/90
Filed: 2020-01-06
Abstract: A polypeptide comprising a first functional fragment, a linker peptide and a second functional fragment comprising a Cas nuclease. Optionally the first functional fragment comprises an exonuclease selected from MRE11, EXOI, EXOIII, EXOVII, EXOT, DNA2, CtIP, TREX1, TREX2, Apollo, RecE, RecJ, T5, Lexo, RecBCD or Mungbean, preferably human Exo1. Optionally the second functional fragment comprises a Cas9 enzyme with a C-terminal nuclear localizing sequence (NLS) and the linker comprises 5 to 200 amino acids and is selected from FL2X, SLA2X, AP5X, FL1X, SLA1X, preferably SLA2X. Also disclosed is a polynucleotide encoding said polypeptide and a vector comprising the polynucleotide.