baber/WOPTO huggingface dataset:
Patent AT-E239166-T1 (AT)
Inventor: MEISTER KLAUS
IPC: E06C1/38
Filed: 1998-07-17
Granted: 2003-05-15
Abstract: The device for allowing a person to safely step off from and onto a climbing track on a roof edge, a roof slope, a shaft opening or similar, includes a guide rail (10) for guiding a catching device to which a person using the climbing path can be secured, and an extension piece (24) of the guide rail (10). The extension piece (24) of the guide rail (10) can be moved between a first and a second position, the extension piece (24) being so arranged in the first position that it does not project above the guide rail (10), and being aligned in longitudinal direction with the guide rail in the second position. The extension piece (24) can be guided displaceable along the guide rail (10) and at a distance from the latter and can be swivelled by 180° in the final position, which corresponds to the second position, so that it is in alignment with the extension (10).
Patent AT-E287221-T1 (AT)
Inventor: ITO M
IPC: A41G3/00
Filed: 1998-09-29
Granted: 2005-02-15
Abstract: A wig fitting implement which performs the fitting of a wig to the head surely and stably, can be put on and off easily, has no bad influence like eczema and a rash to the head skin and has an excellent workability and a method of the use thereof are provided; said wig fitting implement 1 comprises a net-like base 2 divided into four regions of the surface, the back, the left and the right (A side, B side, C side and D side), and double-sided tapes 3 (A1, B1, C1 and D1) and protective tapes 4 (A2, B2, C2 and D2) are stuck to each region. B1 of the B side is stuck to the surrounding rim part 13 of the flexible planar component 9 of the wig 7, and the natural hair 12 of the head skin 10 passes through the penetration holes 6 and is held between C1 and B1 to fix. The fitting of the natural hair 12 is performed surely by inserting the natural hair 12 up to the root thereof through the penetration holes 6 of the wig fitting implement 1. <IMAGE>
Patent AT-E233429-T1 (AT)
Inventor: LANE STEPHEN ERNEST
IPC: H01H3/28
Filed: 1998-12-15
Granted: 2003-03-15
Abstract: An electromagnetic actuator for a circuit breaker having a pair of relatively moveable contacts is disclosed. The actuator includes primary actuator coupled to at least one of the contacts by a link mechanism operable to provide closing and holding forces to the contacts of the circuit breaker and a secondary, faster acting actuator which, on tripping thereof, provides sufficient force to at least initiate opening of the contacts by the configuration of the link mechanism. The secondary actuator includes a stored energy latch which has a permanent magnet flux circuit for providing a holding force and a coil connected to receive a trigger signal to overcome the permanent magnet flux to trip the latch.
Patent AT-E314323-T1 (AT)
Inventor: SHIMADA ATSUSHI
IPC: C03B19/14
Filed: 1999-09-30
Granted: 2006-01-15
Abstract: An object of the present invention is to provide a simple method for producing a quartz glass preform for optical fibers of large size and high quality capable of minimizing the clearance between the core glass rod and the quartz glass tube for the preform, upon producing a quartz glass preform optical fibers in accordance with a rod-in-tube method, suitable to cost reduction, and free from the presence of bubbles at the welded inter surface. A method for producing a quartz glass preform for optical fibers comprising inserting a core glass rod into a quartz glass tube and then heating and melt welding it to obtain a monolithic body, wherein said quartz glass tube preforms has in its longitudinal direction , a mean difference in outer diameter of up to about 1.0 mm, a mean difference in inner diameter of up to about 0.5 mm, an outer diameter circularity of up to about 0.5 mm, an inner diameter circularity of up to about 0.5 mm , and a deviation of circle center for the mean outer diameter of up to about 1 mm with a deviation of the circle center for the mean inner diameter with respect to the circle center for the mean outer diameter of up to about 1 mm , said quartz glass tube having been obtained by mechanically grinding the inner and outer peripheral surface of a high purity quartz glass ingot using diamond abrasive particles and then mechanically polishing the inner peripheral surface thereof with cerium oxide abrasive particles, said quartz glass tube having an OH group concentration of up to about 1 ppm , a chlorine content of up to about 3000 ppm , a gaseous hydrogen discharge quantity of up to about 1.0 x 10<18> molecule/cm<3>, and a water vapor discharge quantity of up to about 2.0 x 10<17> molecule/cm<3>.
Patent AT-E229312-T1 (AT)
Inventor: MADER HELMUT
IPC: A61J3/00
Filed: 1999-10-14
Granted: 2002-12-15
Abstract: The bag (15) is pierced by a spike (13) acting upon an anvil part (14) that contains a second substance (51), separated by a film (16) from a first substance inside the bag. The spike is also used to pierce the film so that when it is used to pierce the bag the two substances are mixed together.
Patent AT-E251418-T1 (AT)
Inventor: MUNCH PAUL-JEAN
IPC: A47K3/34
Filed: 1999-11-23
Granted: 2003-10-15
Abstract: Both the fixed partition wall(s) (1) and sliding door(s) (2) are provided with fittings (3, 7) extending over their top edges (22, 24) to secure them to the support rail (14).
Patent AT-E403611-T1 (AT)
Inventor: SCHMIDT WERNER
IPC: A61F13/15
Filed: 1999-12-13
Granted: 2008-08-15
Abstract: The strip-shaped packaging material (1) for packaging articles (4) provided on one side with an adhesive layer has a surface which faces this adhesive layer and incorporates sections provided with a release coating (2), as well as adjacent sections (3) without a release coating.
Patent AT-E242456-T1 (AT)
Inventor: GRANDVEAU GILLES
IPC: F23D14/06
Filed: 1999-03-15
Granted: 2003-06-15
Abstract: The burner consists of a head (2) made up of a base (20) with a central feed aperture (21) for the air/gas mixture, surrounded by a skirt (22) with radial outlet slits (23). The head is covered by a cap (1) and the upper edge of the skirt has a series of projecting studs (25). The studs are narrower than the distance between adjacent slits and are spaced equidistantly between them; they are located round the inner edge of the skirt.
Patent AT-E255503-T1 (AT)
Inventor: STRINGA LUIGI
IPC: B41J29/46
Filed: 1999-08-23
Granted: 2003-12-15
Abstract: The model for the symbol is captured by an electronic camera from a printed image that is considered acceptable, and the image stored to produce a reference image. The image is then divided into multiple sub-images by superposing a fine grid. During inspection the distance from nodes (K1-K5) of the grid is measured (K'1-K'5), and the reference model adapted to correspond to these measurements.
Patent AT-E339060-T1 (AT)
Inventor: PLUSH CHRISTOPHER
IPC: H04M15/06
Filed: 1999-02-05
Granted: 2006-09-15
Abstract: Subscribers in a mobile communications system are provided with a bundle of call time each billing period, against which standard call types are rated. If, at the end of one billing period, a portion of the bundle for that billing period remains, the rating system associates the remaining portion with a bundle provided for the forthcoming billing period. In one embodiment, rating is interrupted whilst any remaining portions of the previous bundles are added to the newly-created bundles for the next period. In other embodiments, the rating system refers both to the current bundle and to a previous bundle when rating standard call types.
Patent AT-E416674-T1 (AT)
Inventor: CARPENTER CHARLES
IPC: G01N33/68
Filed: 1999-08-06
Granted: 2008-12-15
Abstract: A self-contained signal generating device and methods for using and making the same are provided. The device and methods may detect the presence of a number of different substances, such as proteins, and utilizes a target material binding dye, which may precipitate a target material as well as stain it, and/or undergo a detectable change, e.g., an absorption or emission frequency shift, on binding of the substance to be detected.
Patent AT-E287899-T1 (AT)
Inventor: BORROMEO PETER STANLEY
IPC: A61K9/08
Filed: 1999-08-18
Granted: 2005-02-15
Abstract: A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal ornithine unit, inserting at least one new amino acid or other synthetic unit and closing the ring to produce a new cyclic peptide ring structure. The process allows one to incorporate features such as water-solubility into the cyclic peptide ring nucleus, sites for further modification, increase or decrease the number of amino acid or peptide units within the ring nucleus, and increase or decrease the total number of members within the ring. The invention further provides novel Echinocandin type compounds and their use as antifungal or anti-parasitic agents.
Patent AT-E272434-T1 (AT)
Inventor: MIKKELSEN KAJ S
IPC: A63H33/08
Filed: 1999-10-13
Granted: 2004-08-15
Abstract: A toy building set comprising a plurality of building elements which each are provided with hinge parts, a first type of hinge parts comprising a substantially cylindrical rod-shaped shaft part of a building element, a second type of hinge parts comprising a claw device consisting of two elastic fingers extending outwards from a building element at a distance from each other, so that the two elastic fingers between them form a track which is narrowed at the distal end of the fingers with respect to the building element, so that the rod-shaped shaft part may be pressed into the track through the narrowed part of the track, said hinge parts additionally comprising a third type of hinge parts being provided with a shaft stud which has an external diameter corresponding to the thickness of the rod-shaped shaft part.
Patent AT-E325082-T1 (AT)
Inventor: GAENSICKE FRANK
IPC: G02B6/00
Filed: 1999-12-06
Granted: 2006-06-15
Abstract: In a known method for the manufacture of a tube made of a vitreous material, especially of quartz glass, a hollow cylindrical semifinished product made of a vitreous material is carried essentially vertically to a heating zone, wherein it is heated and drawn off downwards-without the use of tools-to the tube by forming a transitional area from semifinished product to tube, while diameter and wall thickness of the tube are continuously measured, and the tube's measured geometrical data being used to generate a control signal with the aid of which a pressure difference is regulated between pressure P1 in the interior space of the semifinished product, the transitional area and the tube, as well as pressure P2 in the heating chamber which is regulated in the heating zone at least in the transitional area from semifinished product to tube and its adjacent tube area. This method is to be developed further so as to enable the processing of a broader spectrum of hollow cylindrical semifinished products to tubes with the desired inside and outside dimensions. This task is solved according to the invention such that for the manufacture of tubes with the ratio of their outside diameter (DRa) to their inside diameter (DRi) being greater than the ratio of the outside diameter (DHa) to the inside diameter (DHi) of the semifinished product-pressure P1 in the inside space of the semifinished product, the transitional area and the tube being kept at a value which is smaller than the value of pressure P2 in the heating chamber, with pressure P1 being maintained by means of a suction (vacuum) pump.
Patent DE-479709-T1 (DE)
IPC: A23L13/00
Filed: 1991-10-02
Abstract: Casings for food such as sausage are prepared from connective tissue that has been removed from animal tissue in accordance with the process comprising the steps of 1) mechanically separating connective tissue and impurities from animal tissue; 2) treating the connective tissue to remove the fat; 3) reducing the residual bone content of the connective tissue by exposure to acidic materials; 4) separation of the non-collagenous protein and elastin by treating the connective tissue with a first enzyme; and 5) separation of the muscle tissue from the connective tissue by treating with a second enzyme. The step of removing the fat from the connective tissue can be accomplished by one or more of the following steps; A) hydrocarbon extraction of the fat from the connective tissue; B) extraction of the connective tissue with a critical fluid; C) dissolution of the fat with a third enzyme; D) treatment of the fat with a suitable treating agent; E) heat treatment; and/or F) pressure treatment e.g., squeezing by application of force.
Patent DE-694000-T1 (DE)
Inventor: ROBERTS JOHN
IPC: F21V9/00
Filed: 1994-03-24
Abstract: A mirror assembly including an enclosure having an aperture, and defining a cavity, an instrument for receiving electromagnetic radiation having predetermined characteristics, borne by the enclosure and positioned in the cavity; and a dichroic mirror borne by the enclosure and disposed in substantially occluding relation relative to the aperture, the dichroic mirror reflecting ambient visible light and being substantially transparent to the light received by the instrument.
Patent ES-2404205-T1 (ES)
Title: Ésteres procedentes de polioles sólidos y ácidos carboxílicos insaturados
Inventor: DAUTE PETER
IPC: C07C67/08
Filed: 2010-12-30
Abstract: Un procedimiento para la preparación de un éster, al menos basado en a. al menos un componente alcohol, b. al menos un componente ácido carboxílico, c. opcionalmente, aditivos adicionales y d. al menos un catalizador en calidad de componentes del procedimiento, que comprende, en un reactor, las etapas de procedimiento: i. provisión de los componentes del procedimiento, ii. reacción de los componentes del procedimiento para dar un éster A, iii. tratamiento posterior del éster A, en donde - el componente alcohol comprende al menos un poliol que es sólido a 25ºC y - el componente ácido carboxílico comprende al menos 50% en peso de al menos un ácido carboxílico alifático, mono- o poli-insaturado, basado en el peso total de los componentes ácido carboxílico, y en el que al reactor se aplica, al menos durante una parte de la reacción, una presión en un intervalo de 2 - 600 mbar.
Patent ES-2534026-T1 (ES)
Title: Dispositivo y procedimiento de remodelación vaginal
Inventor: GALEN DONALD I
IPC: A61B18/02
Filed: 2013-03-15
Abstract: Un dispositivo para remodelar el tejido genital femenino, que comprende una punta de tratamiento y un mango, en el que la punta de tratamiento está conectada al extremo distal del mango a través de un medio de conexión, en el que el extremo distal de la punta de tratamiento es de forma rectangular, cónica, esférica, semiesférica, oval o circular, y tiene una superficie que comprende uno o más elementos de descarga de energía, en el que dichos elementos tienen una superficie interna y una superficie de contacto con el epitelio, y en el que el dispositivo comprende además uno o más de lo siguiente: (a) uno o más sensores de temperatura para medir la temperatura en o por debajo del epitelio; (b) uno o más sensores direccionales; y (c) uno o más marcadores de profundidad que muestran la profundidad de penetración de la punta de tratamiento dentro de la vagina.
Patent ES-2072232-T1 (ES)
Title: Dispositivo para la fijacion de un cartucho generador de gas generalmente cilindrico en una unidad de accionamiento de tensor de cinturon.
Inventor: SCHMID JOHANNES
IPC: B60R22/46
Filed: 1994-08-05
Abstract: PARA LA FIJACION DE UN CARTUCHO (14) GENERADOR CILINDRICO EN UN BLOQUE (10) DE CARCASA DE UNA UNIDAD DE ACCIONAMIENTO TENSADOR DE CINTURON, SE HA PREVISTO EL BLOQUE (10) DE CARCASA CON UN TALADRO (12), EN DONDE SE ENCAJA EL CARTUCHO (14) GENERADOR DE GAS. SOBRE EL EXTREMO (14A) DEL CARTUCHO GENERADOR EXTERIOR PROVISTO CON UN ENCENDIDO ELECTRICO SE DISPONE DE UN CASQUILLO (18), QUE MUESTRA EN SU EXTREMO SUPERIOR UNA BRIDA (20) DIRIGIDA DE FORMA RADIAL HACIA EL INTERIOR, QUE SE SOLAPA CON LA SUPERFICIE FRONTAL DEL CARTUCHO (14) GENERADOR DE GAS. EN SU EXTREMO AXIAL OPUESTO EL CASQUILLO (20) ESTA PROVISTO CON LISTONES (22) DIRIGIDOS DE FORMA RADIAL HACIA AFUERA, QUE PUEDEN SER APLICADOS MEDIANTE CANALES (12A, 12B) DE GUIA AXIAL EN EL TALADRO (12) Y MEDIANTE EL GIRO DEL CASQUILLO (18) EN UN SENTIDO DE GIRO PREVIAMENTE DETERMINADO ENGRANAN EN UNA RANURA (20) QUE DISCURRE EN LA DIRECCION PERIMETRICA DEL TALADRO, EN DONDE DESEMBOCAN LOS TALADROS (12A, 12B) DE GUIA.
Patent ES-2172494-T1 (ES)
Inventor: BERNDT DIETER
IPC: B65D77/20
Filed: 1999-12-09
Abstract: The invention relates to a resealable plastic packaging container (1) consisting of a tray (2) and a lid film (3) which in the sealing area (4) is sealed to the tray (2) such that it can be at least partly peeled back. The plastic packaging container comprises at least one hook and loop closure (9, 10, 11) whose two complementary parts (9', 10', 11') are arranged opposite each other on the tray (2) and lid film (3), respectively, and by means of which the plastic packaging container can be resealed after the peel-back seal has been opened.
Patent CY-1107473-T1 (CY)
Inventor: UEROEGDI LASZLO
IPC: C07D213/89
Filed: 2006-07-21
Abstract: The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine and its optically active enantiomers. (R)-(-)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine and (S)-(+)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine. Furthermore, the invention relates to the preparation of N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxyimidoyl chloride, which may be used as an active ingredient of medicaments, and the preparation of the optically active enantiomers of this compound using the compounds of the invention as intermediate substances.
Patent CY-1108226-T1 (CY)
Inventor: ALBERICIO PALOMERA FERNANDO
IPC: C07K7/64
Filed: 2008-07-30
Abstract: New analogues of kahalalide F are provided.
Patent CY-1110323-T1 (CY)
Inventor: SUNDARAM MALLIKARJUM
IPC: C12Q1/48
Filed: 2009-06-02
Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
Patent CY-1110276-T1 (CY)
Inventor: RAMAKRISHNA VENKATA SATYA NIROGI
IPC: C07D401/12
Filed: 2010-02-04
Abstract: The present invention provides aminoaryl sulphonamide derivatives of formula (I), useful in the treatment of a CNS disorder related to or affected by the 5-HT6 receptor. Pharmacological profiles of these components include high affinity binding with 5-HT6 receptors along with good selectivity towards the receptor. The present invention also includes stereoisomers, the salts, methods of preparation and medicine containing the aminoaryl sulphonamide derivatives.
Patent CY-1111091-T1 (CY)
Title: Παραγωγα πυριμιδινης που χρησιμοποιουνται ως αναστολεις της ρι-3 κινασης
Inventor: BURGER MATTHEW
IPC: C07D417/12
Filed: 2010-11-12
Abstract: Ενώσεις (I) που αναστέλλουν την 3-κινάση της φωσφατιδυλοϊνοσιτόλης (ΡΙ), τα φαρμακευτικώς αποδεκτά άλατα τους, και πρόδρομα φάρμακα αυτών, σκευάσματα των καινούριων ενώσεων, είτε μόνων τους ή σε συνδυασμό με τουλάχιστον ένα επιπλέον θεραπευτικό παράγοντα, με έναν φαρμακευτικώς αποδεκτό φορέα, και χρήσεις των καινούριων ενώσεων, στην πρόληψη ή στην αντιμετώπιση νεοπλασματικών νοσημάτων που χαρακτηρίζονται από την ανώμαλη δραστηριότητα των αυξητικών παραγόντων, των κινασών σερίνης/ θρεονίνης, και κινασών των φωσφολιπιδίων.
Patent CY-1120550-T1 (CY)
Title: Νεα θεραπεια
Inventor: ABBOTT-BANNER KATHARINE
IPC: A61P11/06
Filed: 2018-08-09
Abstract: Η εφεύρεση παρέχει μια ένωση για χρήση στη θεραπεία ή την πρόληψη μιας νόσου ή πάθησης που επιλέγεται από κυστική ίνωση, χρόνια αποφρακτική πνευμονοπάθεια (ΧΑΠ), άσθμα, ήπια πνευμονοπάθεια, βρογχίτιδα, βρογχιεκτασία, ιδιοπαθή βρογχιεκτασία, αλλεργική βρογχοπνευμονική ασπεργίλλωση, ιγμορίτιδα, ρινική ιγμορίτιδα, μεταβολικό σύνδρομο σχετιζόμενο με τη CFTR (CRMS), παγκρεατίτιδα, ιδιοπαθή χρόνια παγκρεατίτιδα και σύνδρομο Sjorgren, ή για χρήση στην πρόληψη της ανδρικής στειρότητας που προκαλείται από συγγενή απουσία του σπερματικού πόρου, σε έναν ασθενή μέσω της ρύθμισης της δράσης της CFTR, η οποία ένωση είναι η 9,10-διμεθοξυ-2-(2,4,6-τριμεθυλοφαινυλιμινο)-3-(Ν-καρβαμοϋλ-2-αμινοαιθυλ)-3,4,6,7-τετραϋδρο-2Η-πυριμιδο[6,1-a]ισοκινολιν-4-όνη ή ένα φαρμακευτικώς αποδεκτό άλας προσθήκης οξέος αυτής. Η εφεύρεση παρέχει επίσης μια σύνθεση η οποία περιλαμβάνει (i) 9,10-διμεθοξυ-2-(2,4,6-τριμεθυλοφαινυλιμινο)-3-(Ν-καρβαμοϋλ-2-αμινοαιθυλ)-3,4,6,7-τετραϋδρο-2Η-πυριμιδο[6,1-a]ισοκινολιν-4-όνη ή ένα φαρμακευτικώς αποδεκτό άλας προσθήκης οξέος αυτής και (ii) έναν ανταγωνιστή υποδοχέων λευκοτριενίων. Η εφεύρεση παρέχει επίσης μια σύνθεση η οποία περιλαμβάνει (i) 9,10-διμεθοξυ-2-(2,4,6-τριμεθυλοφαινυλιμινο)-3-(Ν-καρβαμοϋλ-2-αμινοαιθυλ)-3,4,6,7-τετραϋδρο-2Η-πυριμιδο[6,1-a]ισοκινολιν-4-όνη ή ένα φαρμακευτικώς αποδεκτό άλας προσθήκης οξέος αυτής και (ii) ένα ενισχυτικό της CFTR ή ένα διορθωτικό της CFTR.
Patent CY-1121561-T1 (CY)
Title: Προοιμιο τηλεμετριας παλμων λασπης για ανιχνευση ακολουθιας και εκτιμηση καναλιου
Inventor: BARAK EHUD
IPC: E21B47/12
Filed: 2019-04-17
Abstract: Μία μέθοδος και ένα σύστημα τηλεμετρίας παλμών λάσπης χρησιμοποιεί ένα προοίμιο που έχει έναν αριθμό περιόδων μιας ακολουθίας συγχρονισμού που ακολουθείται από μία μόνον περίοδο μιας ακολουθίας εκτίμησης καναλιού. Ο συγχρονισμός μπορεί να χαρακτηρίζεται από ένα γενικά επίπεδο φάσμα συχνοτήτων, και η ακολουθία εκτίμησης καναλιού μπορεί να χαρακτηρίζεται από μία χαμηλή διασταυρούμενη συσχέτιση με την εν λόγω ακολουθία συγχρονισμού. Οι ακολουθίες είναι δυνατόν να παράγονται από ένα σύνολο μη επαναλαμβανόμενων διακριτών ακολουθιών. Το προοίμιο μπορεί να είναι κατάλληλο για αμφότερα ανίχνευση ακολουθίας και εκτίμηση καναλιού, να ικανοποιεί το σύνολο των φυσικών και/ή ηλεκτρονικών περιορισμών του συστήματος και να επιτρέπει μία ταχεία σύγκλιση μιας προσαρμοστικής ιχνηλάτησης καναλιού ή συστήματος ισοστάθμισης.
Patent CY-1122352-T1 (CY)
Title: Φαρμακευτικη συνθεση περιεχοντας μιραβεγρονη
Inventor: TAKAE SEIJI
IPC: A61K47/12
Filed: 2019-12-04
Abstract: Να παρασχεθεί: (1) ένα υγρό τροποποιημένης αποδέσμευσης (εναιώρημα) περιέχοντας μιραβεγρόνη, (2) μια έτοιμη-προς-εναιώρηση φαρμακευτική σύνθεση περιέχοντας μιραβεγρόνη, και (3) μια περιέχουσα μιραβεγρόνη φαρμακευτική σύνθεση που δεν παράγει μη-διαλελυμένους σβόλους, ακόμη και όταν εναιωρείται κατά τον χρόνο χρήσης. Η παρούσα εφεύρεση σχετίζεται με μια φαρμακευτική σύνθεση περιέχοντας ένα σύμπλοκο μιραβεγρόνης ή ενός φαρμακευτικώς αποδεκτού άλατος εξ αυτής με νατριούχο σουλφονικό πολυστυρένιο.
Patent CY-1123747-T1 (CY)
Title: Χιμαιρικα μορια τελεστες με σημανση και υποδοχεις αυτων
Inventor: RIDDELL STANLEY R
IPC: C07K14/705
Filed: 2020-12-23
Abstract: Η αίτηση αναφέρεται σε χιμαιρικά μόρια τελεστές με σήμανση και μόρια υποδοχείς αυτών για τη γενετική τροποποίηση ενός κυττάρου ξενιστή, όπου το ανασυνδυασμένο κύτταρο ξενιστής μπορεί να ταυτοποιηθεί, απομονωθεί, διαχωρισθεί, επαχθεί να πολλαπλασιασθεί, ιχνηλατηθεί ή εξαλειφθεί δια της χρήσεως της σήμανσης. Συγκεκριμένα, η αίτηση αναφέρεται σε χιμαιρικούς αντιγονικούς υποδοχείς (CAR) που έχουν ένα εξωκυτταρικό πεδίο που περιλαμβάνει ένα πεδίο δέσμευσης για έναν στόχο, μία περιοχή άρθρωσης και μία κασέτα σήμανσης, ένα υδρόφοβο μέρος ως διαμεμβρανικό πεδίο και ένα ενδοκυτταρικό μέρος με ένα πεδίο τελεστή. Ο προτιμώμενος στόχος είναι το CD19 και η προτιμώμενη σήμανση είναι μία σήμανση Step. Τ κύτταρα που έχουν τροποποιηθεί ανασυνδυασμένα για την έκφραση αυτών των μορίων μπορεί να χρησιμοποιηθούν σε θετή ανοσοθεραπεία.