baber/WOPTO huggingface dataset:
Patent AU-773673-B2 (AU)
Title: New vitamin D derivatives with cyclic substructures in the side chains, method and intermediates for their production and their use in the preparation of medicaments
Inventor: STEINMEYER ANDREAS
IPC: C07D333/22
Filed: 2000-07-24
Granted: 2004-06-03
Abstract: Vitamin D derivatives (I), having a cyclic substituent in the side-chain, are new. Also new are perhydroindane derivative intermediates (A) ands (B).  Vitamin D derivatives of formula (I), including all possible epimers, diastereomers and their mixtures, are new. Y1, Y2  =  H or -C(O)R5;  Y3 (in alpha- or beta-configuration)  =  H, OH, halo, OC(O)R5 or OR5;  R5  =  5-12C aromatic residue; or 1-12C optionally unsaturated alkyl (optionally interrupted by 1 or 2 O, 1 or 2 S and/or 1 or 2 NH; and optionally substituted by 1 or 2 OH, 1 or 2 NH2, 1 or 2 SH, 1 or 2 COOH and/or 1 or 2 COOH);  R1, R2  =  H or together form exocyclic =CH2;  R3, R4  =  H, F, Cl, Br or 1-4C alkyl;  or CR3R4  =  -C(=CH2)- or a 3-7 membered saturated or unsaturated carbocyclic ring;  Q  =  1-5C n-alkylene;  X1, X2  =  H, OH, OC(O)R5, F, Cl or Br (but not both OH or both -OC(O)R5);  or CX1X2  =  C=O;  Z'  =  carbocyclic or heterocyclic (including aromatic or heteroaromatic) ring system comprising a 5- or 6-membered ring optionally fused with a 6-membered ring (optionally substituted by one or more of each of halo, OH, COOR6 or 1-5C alkyl (itself optionally substituted by one or more of halo, 1-6C alkoxy and/or COOR6));  R6  =  1-6C alkyl, benzyl or phenyl. Independent claims are included for: (1) new perhydroindane derivative intermediates of formulae (A) and (B); (2) preparation of perhydroindane derivative intermediates of formula (XIIIa) by: (a) reacting a perhydroindane derivative of formula (A; T replaced by L) with protected, deprotonated propargyl alcohol to give (A; T = -CC-CH2OY5), (b) hydrogenating and deprotecting to give (A; T = -(CH2)3OH), (c) oxidizing to give (A; T = -CH2CH2CHO) and (d) reacting with a nucleophile Nu, cleaving Y4 and oxidizing the free OH group; and (3) preparation of vitamin D compounds of formula (IIa) by: (a) reacting a ketone of formula (XIIIb) with a trimethylsilyl acetoacetate ester in presence of a base or with a Wittig reagent in an aprotic solvent to give (B; U = COOR6), (b) reducing to give (B; U = CH2OH), (c) converting into (B; U replaced by L), (d) converting into the Wittig reagent (B; U = CH2P(O)(G)2) and (e) reacting with a ketone of formula (XXXIII) and optionally deprotecting the product.  T  =  -CC-CH2OY5, -(CH2)3OH or -CH2CH2CHO;  Y4  =  trialkylsilyl, mixed aryl-alkyl substituted silyl, tetrahydropyranyl or tetrahydrofuranyl protective group;  Y5  =  tetrahydropyranyl or benzyl;  E  =  side-chain, in which any keto and/or hydroxy groups are protected;  U  =  COOR6, CH2OH or CH2P(O)(G)2;  Y6  =  1-6C alkyl, benzyl or phenyl;  G  =  1-10C alkyl, 1-10C alkoxy, Ph or OPh;  L  =  leaving group;  Nu  =  nucleophile;  R7, R8  =  H or Me; or together form exocyclic =CH2 or a cyclopropane ring;  Y6  =  F, (CH2)nOH or (CH2)nOCOR5;  n  =  0-4;  Y'1  =  hydroxy-protecting group;  Y'3  =  H, halo or as Y'1.
Patent AU-544892-B2 (AU)
Title: Hot sprue valve
Inventor: CANE ALBERT
IPC: B29C45/26
Filed: 1981-08-18
Granted: 1985-06-20
Abstract: A hot sprue valve assembly is provided for controlling flow of molten material through a hot sprue bushing of an injection molding machine. The valve assembly is particularly designed for use with an injection molding machine for molding centrally apertured record discs, such as video information discs, and the valve assembly includes means for forming the central aperture in the disc. In one embodiment, the aperture-forming means comprises a sleeve valve for molding the aperture in the disc prior to solidification of the disc-forming melt, whereas in another embodiment the aperture-forming means comprises a punch for punching the aperture subsequent to solidification of the disc-forming melt.
Patent AU-680053-B2 (AU)
Title: Method and apparatus for forming and collecting surgical slush
Inventor: FARIES DURWARD I JR
IPC: F25C1/12
Filed: 1994-09-14
Granted: 1997-07-17
Abstract: Frozen pieces o sterile medium, such as saline, are dislodged from a sterile drape container in a surgical slush producing machine by manipulating the drape relative to the cooled basin to which the drape container conforms. Manipulation of the drape is achieved by pushing, twisting, pulling, lifting, etc. on the drape to displace it from the basin. Such movement of the drape may be effected on a continuous and automatic basis, or by manual means using a member or implement to facilitate drape movement. The system cabinet includes a refrigerated compartment for pre-chilling sterile liquid to be used in forming the surgical slush.
Patent AU-732120-B2 (AU)
Title: Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
Inventor: BORSTEL REID WARREN VON
IPC: C07H19/10
Filed: 1998-08-05
Granted: 2001-04-12
Abstract: Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
Patent AU-550750-B2 (AU)
Title: Optically readable record carrier
Inventor: OHGA NORIO
IPC: B41M5/24
Filed: 1982-03-30
Granted: 1986-04-10
Abstract: A record carrier has a spiral track (2) in which sound and/or video information is stored formed on a transparent substrate (1) and covered by a reflecting layer (8) of metallic material for reflecting a reading beam. The metallic layer (8) does not extend to the inner and/or the outer edge portion (4, 5) of the substrate (1) and is covered by a protective layer (12). The protective layer (12) is extended to the inner and/or the outer edge portion (4, 5) of the substrate (1) so as to seal the metallic layer (8) for preventing oxidation thereof.
Patent AU-735230-B2 (AU)
Title: Polymorphic form of the tachykinin receptor antagonist 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl) phenyl)ethoxy)-3-(S)-(4-fluoro) phenyl-4-(3-5 (-oxo-1H,4H-1,2,4,-triazolo) methylmorpholine
Inventor: CROCKER LOUIS
IPC: A61P43/00
Filed: 1998-07-01
Granted: 2001-07-05
Abstract: This invention is concerned with a novel polymorphic form of the compound 2-(R)-(1-(R) -(3,5-bis(trifluoromethyl) -phenyl)-ethoxy)-3-(S)-(4-fluoro) phenyl-4-(3-5 (-oxo-1H,4H-1,2,4-triazolo) methylmorpholine which is a tachykinin receptor antagonist useful in the treatment or prevention of disorders of the central nervous system, inflammatory diseases, pain or migraine, asthma, and emesis. The instant polymorphic form has advantages over the other known forms of 2-(R)-(1-(R) -(3,5-bis(trifluoromethyl) -phenyl)ethoxy)-3-(S )-(4-fluoro) phenyl-4-(3-5 (-oxo-1H,4H-1,2,4-triazolo) methylmorpholine in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations.
Patent AU-553689-B2 (AU)
Title: 7-bromo-5-(2-halophenyl)-1h-2,3-dihydro-1,4-benzodiazepine compounds
Inventor: ZEUGNER HORST
IPC: C07D243/16
Filed: 1982-09-29
Granted: 1986-07-24
Abstract: Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I    <IMAGE>  I  in which R1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R2 is a halogen atom. The compounds possess psychopharmacological, and especially anti-aggressive properties. To manufacture compounds of formula I, corresponding 2-halomethyl-7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines are cyclized to corresponding 7-bromo-1,2-methylene-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines and in these the aziridine ring is opened through treatment with a lower alcohol or a lower carboxylic acid in the presence of a Lewis acid.
Patent AU-655952-B2 (AU)
Title: A method and an arrangement for producing spunlace material, and material produced thereby
Inventor: BILLGREN TOMAS
IPC: D04H1/44
Filed: 1991-11-18
Granted: 1995-01-19
Abstract: PCT No. PCT/SE91/00779 Sec. 371 Date May 11, 1993 Sec. 102(e) Date May 11, 1993 PCT Filed Nov. 18, 1991 PCT Pub. No. WO92/08832 PCT Pub. Date May 29, 1992.The present invention relates to a method for producing spunlace material in which there is formed a fibrous web by air-laying a layer of fibres of staple length on a forming wire and air-laying a layer of short fibres on top of the layer of staple fibres. According to the invention, the fibrous web is passed to an entangling wire 18 on which there is arranged at least one elongated element 17 whose diameter is much greater than the diameter of the wires 16 in the entangling wire 18, whereafter the fibrous web is entangled. The invention also relates to an arrangement for carrying out the method, and to a spunlace material produced in accordance with the method.
Patent AU-554706-B2 (AU)
Title: Suitcase with frame element, lateral elements and various accessory elements
Inventor: SCHAUB M M ZINTZMEYER J
IPC: A45C5/02
Filed: 1982-11-03
Granted: 1986-08-28
Abstract: The novel case contains at least one rigid, obstacle-free basic frame element with a U-shaped profile and laterally fittable, interchangeable lateral elements. The latter can be in the form of e.g. plates, case shells or lateral covers provided with roller shutters. The case can be opened between the basic frame element and one of the lateral elements. The volume within the profile makes it possible to receive different additional elements. Examples of the latter are locking elements, carrying handles, name plates, identification elements, accessories, roller elements and carrying straps. The basic frame element can be in the form of a rectangle, square, polygon or circle.
Patent BG-61895-B2 (BG)
Title: Homogenous human interleukin 2
Inventor: STERN ALVIN S
IPC: C07K14/55
Filed: 1992-07-16
Abstract: The invention relates to human interleukin 2 (IL-2) producedfrom induced human malignant cells and purified to homogeneity bymaking use of a multistage highly productive liquid chromatography(HPLC). The purified IL-2 shows great activity by increasing thelong-lasting cultivation in vitro of antigen specific effectiveT-lymphocytes and stimulates the lymphocytic reactivity.2 claims
Patent BG-63182-B2 (BG)
Title: Vaccination by specific t-cell populations against diseases caused by pathogenic responses
Inventor: HOWELL MARK D
IPC: C07K14/725
Filed: 1993-04-26
Abstract: The invention relates to vaccines and vaccination means of a host with the intention of prevention or controlling specific T-cell determined proliferation diseases. The vaccine is made of pharmaceutically acceptable medium and a segment of T-cell receptor (TCR) found on the surface of the T-cells, determining the disease. The vaccine is applied on the host in a manner which induces an immune response, directed to the TCR of pathogenic T-cells. This immune response regulates or deletes the pathogenic T-cells, and in this way stops of the pathogenesis of the disease. The invention also relates to means for the determination of suitable amino acid sequence for such a vaccine. 6 claims
Patent DE-1961015-B2 (DE)
Title: Circuit preventing shared telephone being engaged by two calls - applies blocking potential to all switching circuits not involved so that only one can be active at any time
IPC: H04Q3/00
Filed: 1969-12-05
Abstract: The circuit prevents a shared telephone being engaged by two or more calls simultaneously by applying a blocking potential to all switching circuits not involved, ie only one switching circuit an be active at any time. This is achieved by inter-connecting all switching circuits and blocking gates so that they are interdependent. The advantage lies in requiring the same circuitry per terminal (coupled to the shared device being protected) irrespective of the number of terminals coupled to the device. The common transistor (T3) is controlled via the diode (D11) and resistor (R8). The common transistor (T3) controls the transistors (T12, T22... Tn2) via the resistors (R17, R27... Rn7).
Patent DE-2002777-B2 (DE)
Title: Earth-short detecting circuit for AC generator neutral line - has single- and three-phase transformers coupled via divider to third-harmonic detector
IPC: H02H3/52
Filed: 1970-01-19
Abstract: The earth-short detecting circuit is included in the neutral line of a three phase generator in its star windings, and and has a single-phase transformer (FV') connected by its primary between earth and the generator's neutral, and a three-phase transformer (FV") connected by its primary between earth and the generator's terminals and its secondaries are connected to form an open delta winding. A voltage divider (Z', Z") is connected to the terminals of the series-coupled secondaries of both transformers. The divider's tapping is connected via a voltage detector (1, 2), which detects the system's third harmonic, to the secondary windings common point.
Patent DE-2138597-B2 (DE)
Title: Large excavator bucket wheel electrical drive - has sliding stator on shaft and rotor on bucket wheel
IPC: E02F3/24
Filed: 1971-08-02
Abstract: The electrical drive for bucket wheels of large excavators and loaders has a stator which is connected to the fixed shaft of the bucket wheel. The rotor rotates with its pole pieces about this shaft. No mechanical drive is used with associated complicated systems and energy losses. Power is more efficiently transmitted to bucket wheels which can have relatively large dimensions. The wheel (38) with pole pieces of the rotor is fastened on the bucket wheel (44). The stator together with its support is held on the bucket wheel shaft (10) so that it can be axially displaced. The wheel (38) is held by radial arms on the hub (42) on the shaft.
Patent DE-2144563-B2 (DE)
Title: Metal console shelf bracket with angled arms - fits into hollow angled plastics over member attached to shelf
IPC: A47B96/06
Filed: 1971-09-06
Abstract: The console shelf bracket comprises a metal angle member wherein one arm (17) is to be fastened vertically against the wall whilst the other arm (12) which is to support the shelf (14) and extends away from the wall engages in a sliding seat in the hollow arm (13) of an angled plastics component (15) which covers the metal parts. The other arm (16) of the plastics component (15) is a cap to fit on the wall arm (17) of the metal angle so that it lies flush with the face of the metal arm (17) facing the wall (11). In this way any suitable fastening means can be used to fix the metal angle to the wall since the plastics cover is not fitted on until afterwards. The metal arm extending away from the wall is preferably shorter than its encasing plastics arm.
Patent DE-2214002-B2 (DE)
Title: Scanning system for charge-storage TV camera - suppresses storage noise by starting scan in unmodulated region of signal plate
IPC: H04N5/32
Filed: 1972-03-22
Abstract: The scanning system suppresses noise caused by charge storage and reduces the modulated region contg. the wanted information w.r.t. the signal plate's overall area so that scanning starts in an unmodulated region that contains only the noise component and passes over into the modulated region. A switch connects the video channel to a hold circuit comprising a capacitor and a comparator. The difference signal is applied to a control device that alters the potential between cathode and signal plate during the time for which the unmodulated region is scanned such that the two compared values tend to become the same.
Patent DE-2218643-B2 (DE)
Title: Static inverter with astable multivibrator - is arranged to feed pushpull transistor and transformer circuit via variable resistor
IPC: H02M7/538
Filed: 1972-04-18
Abstract: The static inverter has an oscillator supplied from a stabilised dc source and feeding a transistor push-pull circuit coupled to an output transformer. The output voltage amplitude of the inverter is controlled by comparing with a reference. The oscillator is constructed as an astable multivibrator (T1, T2) and has its freq. set by a variable resistor (RV3). The two oppositely-phased outputs of the multivibrator are passed via voltage dividers--consisting of two fixed resistors (R17, R18) and a variable resistor (T3)--to the push-pull circuit where they are used as control signals. The advantage lies in giving a variable frequency output with high frequency whilst retaining a simple configuration.
Patent ES-2168912-B2 (ES)
Title: Cuadro soporte compacto para actividades artisticas.
Inventor: BLANCO PIQUERO FRANCISCO
IPC: B44D3/18
Filed: 1999-09-08
Granted: 2003-06-16
Abstract: Cuadro soporte compacto para actividades artísticas, del tipo de cuadros utilizados por artistas pintores, que se constituyen por un lienzo o tela tensada para efectuar sobre ella la pintura, presentando el cuadro soporte compacto (1) por su cara frontal la tela o lienzo (2) susceptible de ser imprimada y preparada, y recubierta por su cara dorsal por polímeros orgánicos o resinas sintéticas (3), armadas y reforzadas, que al polimerizar le otorgan una total rigidez y planitud y una durabilidad ilimitada, definiéndose un conjunto solidario y compacto, que puede incorporar también un marco embellecedor.
Patent IE-S79242-B2 (IE)
Title: Apparatus and method for processing bivalves
Inventor: KEOHANE MICHAEL
IPC: A22C29/04
Filed: 1997-11-28
Abstract: An apparatus for processing bivalves, such as mussels, comprises a container (1) having an open top closed by a lid (11). The lid (11) includes a circular plate (16) which is biassed down into the open top of the container by springs (12) to place the mussels in the container under pressure while they are cooked. Means are provided for adjustng the pressure applied by the springs (12) to the plate (16).
Patent JP-3310039-B2 (JP)
IPC: A01N43/80
Filed: 1993-02-04
Granted: 2002-07-29
Abstract: 4-Benzoyl isoxazole derivatives of general formula (I): <CHEM>     wherein     R represents a hydrogen atom or a group -CO2R<5>; R<1> represents methyl, isopropyl, cyclopropyl or 1-methylcyclopropyl;     R<2> represents -S(O)nR<5><1>; R<3> represents a chlorine, bromine or fluorine atom, a straight- or branched- chain alkyl, alkoxy, haloalkyl or haloalkoxy group, an alkenyl group or a methyl or ethyl ester group; R<4> represents a chlorine, bromine or fluorine atom; an alkyl, alkoxy haloalkyl, haloalkoxy, -S(O)pR<5><3> or cyano group;     R<5> represents an alkyl or haloalkyl group;     R<5><1> and R<5><3> independently represent an alkyl group, and     n and p independently represent zero, one or two, and their use as herbicides is described.
Patent JP-H0579337-B2 (JP)
Inventor: GUNTAA RENCHURAA
IPC: A61B17/22
Filed: 1991-02-20
Abstract: A lithotripsy installation with a shock wave generator (4) is described, which has a coupling cushion (34) which can be shaped to the body of the patient and can be filled with water as acoustic coupling medium between the body of the patient and the shock wave generator (4). The water is degassed in order to ensure an efficient shockwave therapy and is continuously conditioned in order to prevent slime formation, for example as a result of algae growth, and the risk of transmission of germs, this conditioning being effected by a disinfection arrangement (1) (Figure). 
<IMAGE>
Patent JP-3940455-B2 (JP)
IPC: A61M5/31
Filed: 1997-01-30
Granted: 2007-07-04
Abstract: A two-compartment type prefilled syringe (K1) including a first rubber stopper (6) fitted into a front sleeve (7), a second rubber stopper (9) fitted into a rear end portion of a cartridge (1), a third rubber stopper (12) for hermetically dividing interior of the cartridge (1) into front and rear compartments (14, 16) and a bypass (18) formed by radially outwardly bulging a portion of a peripheral wall of the cartridge (1), wherein in an axial direction of the cartridge (1), a length (20) of the third rubber stopper (12) is slightly smaller than an inner length (19) of the bypass (18), wherein when the third rubber stopper (12) has been displaced into the bypass (18), sealing property of the rear compartment (16) against the front compartment (14) is cancelled such that dissolving agent (15), suspension or the like in the rear compartment (16) is carried, via the bypass (18), into the front compartment (14) containing dry medicament (13) or the like, wherein a ratio (R) of a maximum width (b) of one end of the bypass (18) adjacent to the front sleeve (7) to a maximum width (a) of the other end of the bypass (18) adjacent to the rear end portion of the cartridge (1) is set to range from 1.2 to 5.0. <IMAGE>
Patent JP-H0755851-B2 (JP)
IPC: C04B28/02
Filed: 1987-02-20
Abstract: A cured cement article containing therein an organic polymer treated with an isocyanate compound has a high flexural strength and high water resistance. The article can be prepared by impregnating a cured cement article containing therein a water-soluble polymer or a water-dispersible polymer with an isocyanate compound, or by starting from a cement composition containing the polymer and the isocyanate compounds.
Patent JP-H0824714-B2 (JP)
IPC: B05B5/08
Filed: 1987-02-20
Abstract: A process for the production of solid particles, characterised by the solidification in flight of an electrically charged spray of fluid droplets of narrow particle size distribution, and an apparatus for that process comprisinga sprayhead (1) with a channel (17) for the fluid communicating with an outlet;means for subjecting the fluid to an electrical field such that the fluid will move from the sprayhead (1) under the influence of the field to produce a spray of the fluid, the means including means for applying a first potential to the fluid;an electrode (11) mounted spaced from but adjacent to the sprayhead (1) with means to apply a second potential to that electrode; anda spray chamber (14), so positioned that in use the sprayhead (1) delivers the spray to the chamber interior, and provided with means to apply a third potential to the chamber, and so dimensioned and arranged that in use the majority of the spray droplets solidify before impinging on any surface of or within the chamber.
Patent JP-H0468433-B2 (JP)
IPC: E05C9/22
Filed: 1982-03-10
Abstract: Push bar fittings which extend in longitudinal grooves of the frames of windows, doors, or the like, are provided with holding means by which ribs projecting from the side walls of the groove are engaged from below, with the push bar being mounted for displacement above the ribs. To provide as wide a range as possible for cutting the push bar to length, and, on the other hand, to obtain a good guidance of the push bar ends in spite of that, the push bar is provided at the level of the ribs with a portion correspondingly sloping toward the groove bottom. Consequently, the free end of the push bar then extends in the groove portion below the ribs and is thus prevented from moving out of the longitudinal groove.
Patent EP-1254144-B2 (EP)
Inventor: DAVIS KEITH PHILIP
IPC: C02F5/14
Filed: 2001-01-31
Granted: 2008-12-17
Abstract: Compounds of formula (I), wherein each of R and R' are independently selected from hydrogen, a hydroxyl group, a carboxyl group, an alkyl, aryl or alkaryl group or a hydroxy or carboxy substituted alkyl, aryl or alkaryl group, provided that R R', together have a total of less than 23 carbon atoms, R'' may either be hydrogen or a CHR=CR1 group or be selected from the same categories as R'''; R''' is a group, or polymeric chain comprising from 1 to 100,000 groups, said group or groups being derived form at least one ethylenically unsaturated compound wherein the double bond is activated by an adjacent electron withdrawing group, and n is greater than 1 are novel, are useful corrosion inhibitors and are valuable intermediates in preparing telomers for use in water treatment.