baber/WOPTO huggingface dataset:
Patent NZ-511629-A (NZ)
Title: A method for determining a mimotope sequence
Inventor: SLOOTSTRA JELLE WOUTER
IPC: C12Q1/68
Filed: 1999-11-15
Abstract: The specification relates to a method for determining a mimotope sequence for a receptor, including the following steps; *Providing a solid support with a random library of test sequences composed of building blocks chosen from the group of amino acids, monosaccarides and nucleotides, *Determining the activity of each test sequence of the library towards the receptor *Identifying the test sequence comprising at a certain position a building block which according to the results of step b) is favored at this position *Providing the next library of test sequences to be used based on the test sequence identified in step c) by replacing a building block at selected positions of the identified test sequence with selected building blocks *Determining the activity of each test sequence of the library provided in step d) towards the receptor *Identifying a test sequence comprising at certain positions a building block which according to the results of step e) is favored at the said position *Repeating steps d-f) for the library of test sequences provided in step d) for a number of cycles sufficient for finding in step f) a mimotope sequence that gives sufficient activity towards the receptor where each test sequence is located on a minicard or flat support system
Patent NZ-513254-A (NZ)
Title: Thioamide derivatives
Inventor: HULL KENNETH GREGORY
IPC: C07D233/84
Filed: 2000-02-10
Abstract: A thioamide derivative or pharmaceutically acceptable salts and esters thereof has the formula (I) wherein: X is a group of the formula (X-1), (X-2) or (X-3); Y is a group of formula (Y-1), (Y-2), (Y-3); R15 is halogen, nitro, alkyl sulphonyl, cyano, alkyl, alkoxy, alkoxycarbonyl, carboxy, alkyl aminosulphonyl, perfluoroalkyl, alkylthio, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, alkylsulphinyl, alkanoyl, aroyl, aryl or aryloxy; R16 is hydrogen, halogen, nitro, cyano, alkyl, OH, perfluoro alkyl, or alkylthio; Het is a 5-or 6-membered heteroaromatic ring containing 1, 2 or 3 heteroatoms selected from N, O, and S or a 9-or 10- membered bicyclic heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms selected from O, S, and N; R30 is hydrogen or alkyl; p is 0 or 1; R18 is aryl, heteroaryl, arylalkyl, or heteroarylalkyl R19 is optionally substituted alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl; R20 is optionally substituted alkanoyl or aroyl; R22 and R23 are independently hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, nitro, cyano, alkylthio, alkylsulphinyl, alkylsulphonyl, alkanoyl, halogen, or perfluoroalkyl provided that at least one of R22 and R23 is other than hydrogen; R24 is hydrogen, alkyl, alkoxy, aryl, nitro, cyano, alkylsulphonyl, or halogen; or Y-2 is a group of the formula: Het' is a five or six membered heteroaromatic ring bonded via a carbon atom containing one, two or three heteroatoms selected from the group consisting of, O and S; R30' and R31 are independently hydrogen, alkyl, cycloalkyl, halogen, cyano, perfluoroalkyl, or aryl provided at least one of R30' and R31 is adjacent to the point of attachment; R25 is alkyl, alkenyl, fluoroalkenyl, or a group of formula R26-(CH2)e-, Q is -(CH2)fO-, -(CH2)fS-, -(CH2)fN(R27)-, -(CH2)f or a bond; R26 and R27 are as defined in the specification; e is 0 to 4, f is 1 to 3, and the dotted bond is optionally hydrogenated. The compounds are useful for the treatment or prophylaxis of rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease and asthma.
Patent NZ-517559-A (NZ)
Title: Sustained release pharmaceutical composition containing tramadol saccharinate
Inventor: BARTHOLOMAUS JOHANNES
IPC: A61P25/14
Filed: 2000-08-03
Abstract: An administration form of tramadol is provided with at least one sustained-release coating, which contains the active substance tramadol as tramadol saccharinate, optionally together with other auxiliary substances.
Patent NZ-519034-A (NZ)
Title: Bovine immunodeficiency virus (BIV) based vectors
Inventor: LUO TIANCI
IPC: A61K35/76
Filed: 2000-12-13
Abstract: A BIV vector construct comprising: (a) a functionally active DNA segment from a Sly genome; (b) a packaging sequence to package RNA into virions; (c) a first promoter operably linked to the DNA segment; and (d) a transgene operably linked to a second promoter. Also disclosed are two and three vector systems comprising such a construct.
Patent NZ-519925-A (NZ)
Title: Amides, useful in the inhibition of IL-8-induced chemotaxis of neutrophils
Inventor: ALLEGRETTI MARCELLO
IPC: C07D209/46
Filed: 2001-02-06
Abstract: Disclosed are (R)-enantiomers of 2-aryl-propionic amide compounds of formula (Ia), wherein: Aryl is a phenyl group substituted with a group selected from isopropyl, acetyl, (2", 6"-dichlorophenyl)amino, á-hydroxyisopropyl, (R,S) á-hydroxyethyl and its single R and S isomers, (R,S)-á-hydroxybenzyl and its single R and S isomers, (R,S)-á-methylbenzyl and its single R and S isomers, and (R,S)-á-hydroxy-á-methylbenzyl and its single R and S isomers, R is H, alkyl, allyl, propargyl, CH2-CO2H or (CH2)2-CO2H, and the remaining substituents are defined herein. Also disclosed is the use of (R)-enantiomers of 2-aryl-propionic amide compounds of formula (I) in the manufacture of medicaments for the treatment of pathologies related to inhibition of the chemotaxis of neutrophils induced by interleukin-8 (IL-8), such as psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, rheumatoid arthritis, ischemia and reperfusion, wherein: Aryl is a phenyl group substituted by one or more groups independently selected from halogen, alkyl, alkoxy, hydroxy, acyloxy, cyano, nitro, amino, acylamino, halo-alkyl, hydroxy-alkyl, halo-alkoxy, hydroxy-arylalkyl, benzoyl or the known moiety of known anti-inflammatory 2-arylpropionic acids, R is H, alkyl, allyl, propargyl, CH2-CO2H or (CH2)2-CO2H, and the remaining substituents are defined herein.
Patent NZ-524746-A (NZ)
Title: A device and a method for filtering a fluid
Inventor: BOYE BO
IPC: B01D39/04
Filed: 2001-09-17
Abstract: A device for filtering a fluid is provided, wherein said filtering device comprises a fibre housing (1) having an inlet end (5) with at least one inlet and an outlet end (3) with at least one outlet. The fibre housing surrounds and defines an outer bound for a plurality of fibres (2) extending longitudinally in the fibre housing between the inlet end and the outlet end, whereby longitudinally extending interspaces is provided between the fibres, with said interspaces defining a plurality of flow passages for the fluid. At least part of the fibre housing is formed of a flexible membrane surrounding the fibres, and compressing means (7a,7b) is provided for creating a pressure on an outer surface of the flexible membrane thereby compressing the fibres in a radial direction at least one location along the length of the fibres.
Patent NZ-527879-A (NZ)
Title: Pharmaceutical composition made of cannabis extracts
Inventor: WERNER MICHAEL
IPC: A61K47/26
Filed: 2002-02-15
Abstract: Disclosed is a pharmacologically active composition which is suitable for use in palliative cancer therapy and as remedy with a muscle-relaxing and/or pain relieving effect in neurological disorders, the composition comprising at least 80% by weight of tetrahydrocannabinol (THC) and cannabidiol (CBD), calculated from the total weight of the cannabinoids present in the composition, with the THC:CBD ratio by weight being 75:25 to 20:80. Further disclosed is a process for producing the composition and administration forms comprising it.
Patent NZ-531047-A (NZ)
Title: Device and method for simulation of the presence of one or more sound sources in virtual positions in three-dimensional acoustic space
Inventor: AGOSTINI LUIGI
IPC: H04S1/00
Filed: 2002-07-09
Abstract: A method for simulating the presence of one or more sound sources in virtual positions (8) in acoustic space (7) using a system that comprises:- (a) A plurality of loudspeakers (2) located in an environment (1) in which the listener is situated; and (b) A means designed to drive the loudspeakers independently of one another, characterised in that the behaviour of the direct sound and reflected sounds is reconstructed separately in a virtual environment which lies outside the area in which the listener is situated, wherein: (i) The distance between the position of the virtual source and the listener's position is calculated; (ii) The direction of the line which joins the source to the listener is calculated; (iii) A subset of loudspeakers is selected which will be used to transmit the direct sound and a set of reflected sounds using the direction of a line that joins the listener to the sound source or the area of the virtual wall at which the reflection takes place; (iv) The amplitude components relating to the emissions of the selected loudspeakers (12) are calculated in such a way that the vector sum of the sound emitted by the loudspeakers is equivalent to the direct sound emitted by the virtual source (10) and/or the reflected sound emitted by the virtual source.
Patent NZ-531192-A (NZ)
Title: Process for producing 1,4-dihydroxy-2-naphthoic acid and compositions made therefrom for regulating intestinal function
Inventor: SATO YOSHIO
IPC: A23L1/30
Filed: 2002-08-06
Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving enteric flora, alleviating abdominal ailments in association with the intake of milk and preventing metabolic bone diseases.
Patent NZ-531479-A (NZ)
Title: Charging System
Inventor: SARUHASHI NOZOMU
IPC: H04N21/2543
Filed: 2002-08-06
Abstract: A billing system to charge for a service when a user receives a service which is chosen from contents provided by at least one content provider comprises at least one user's device, at least one content provider's device, and a payment server. The user's device comprises: a videophone whose screen presents icons for choosing one of the contents; a bill collector which receives transaction information transmitted from the payment server via a communication line, which outputs the transaction information so as to prompt the user to make a payment, and which in turn transmits payment amount information to the payment server via the communication line and a terminal booth which houses the videophone and the bill collector and has a space which permits the user to operate inside. The content provider's device comprises: a videophone which is arranged to be bidirectionally connected to the videophone of the user's device via a telephone line and a computer having a display unit and an input unit, wherein when the videophone is connected via the line, the computer performs a process in which a location of the user's device is retrieved according to caller's telephone number information and shown on the display unit, a process in which transaction information entered by the input unit is transmitted to the payment server via a communication line, and a process in which payment amount information is received from the payment server via the communication line and shown on the display unit. The system is arranged such that the user inside the terminal booth of the user's device receives a service from the content provider by operating the videophone and that the user pays for the service by means of the bill collector housed in the terminal booth.
Patent NZ-531556-A (NZ)
Title: Phenyl-piperazine derivatives as serotonin reuptake inhibitors
Inventor: RUHLAND THOMAS
IPC: C07D211/70
Filed: 2002-10-02
Abstract: Disclosed is a compound of formula (I); wherein Y is N, C or CH; X is S; m is 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; q is 0, 1, 2, 3 or 4; s is I or 2; the dotted line represents an optional bond; each R1 is independently selected from the group consisting C1-6-alkyl, or two R1 attached to the same carbon atom may form a 3-6-membered spiro-attached cyclo-alkyl; each R2 is independently selected from the group consisting of C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl, hydroxy, hydroxy-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, acyl, C1-6-alk(en/yn)yloxycarbonyl, C1-6-alk(en/yn)ylsulfonyl, -NRxRy, and -NRxCO-C1-6-alk(en/yn)yl; each R3 is independently selected from the group consisting of C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl, hydroxy, hydroxy-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)ylsulfonyl, aryl, C1-6-alk(en/yn)yloxycarbonyl, acyl, -NRxRy, CONRxRy, and -NRxCO-C1-6-alk(en/yn)yl; or two adjacent R3 substituents together form a heterocycle fused to the phenyl ring selected from the group consisting of formula (II) to (VI). Further disclosed are pharmaceutical compositions comprising a compound of formula (I), and the use of compounds of formula (I) in the preparation of a medicament for the treatment of affective disorders, anxiety disorders or an obsessive compulsive disorder.
Patent NZ-532448-A (NZ)
Title: Cast composite sail and method
Inventor: CONRAD PETER G
IPC: B63H9/06
Filed: 2002-09-20
Abstract: A sail with a seamless body is produced by transporting a flexible carrier over a segmented support through a series of stations in which a coating of liquid synthetic resin is deposited on the carrier in a predetermined pattern conforming substantially to the desired configuration for the sail and the segments of the support are moved to the carrier and coating into the predetermined contour for the transverse portion of the sail disposed thereon concurrently with passage of said carrier thereover. Structural yarns are deposited in the coating in a predetermined pattern, and additional liquid synthetic resin to a desired depth for the coating corresponding substantially to the desired thickness for the sail and to encapsulate the structural yarns. The resin on said carrier is cured to produce a composite sail structure having the desired configuration and contours with structural yarns being embedded in the cured resin. The composite sail structure is removed from the carrier and trimmed, following which finishing operations are performed thereon.
Patent NZ-532944-A (NZ)
Title: Stable, topical formulation for treating viral and inflammatory conditions comprising 10% n-docosanol, 5% of a stearate, 8% mineral oil, 5% propylene glycol, 2.7% benzyl alcohol and water
Inventor: KATZ DAVID H
IPC: A61K47/44
Filed: 2002-10-15
Abstract: Described are topical therapeutic preparations and methods for treating viral and inflammatory diseases and for reducing the pain of topical inflammation of skin and mucous membranes. The preparations include creams containing n-docosanol. The figure depicts data showing the dose-response relationship of Formulation III for the inhibition of HSV-2 induced cutaneous lesions in hairless guinea pigs.
Patent NZ-533515-A (NZ)
Title: Shopping trolley
Inventor: FRASER MARK ANDREW
IPC: B62B3/14
Filed: 2002-11-20
Abstract: A shopping trolley (10) has a basket (11), handle (12) and front and rear wheels (13, 14). The basket, tapered in plan view, has side walls (15, 16) interconnected by a front wall (17). The rear wall (19) is hingedly connected to the side walls and engages the rearward end of the floor (22), which is hingedly connected to the side walls or front wall. The floor is downwardly inclined from the rearward end to the forward end. When the trolley is nested with a similar trolley, the rear wall is swung inwardly and upwardly, causing the floor to be swung upwardly to be behind the front wall. Alternatively, the floor may be folded, e.g. in a concertina-like fashion, to be behind the front wall.
Patent NZ-534658-A (NZ)
Title: Trip lever assembly
Inventor: RISCHE DAVID K
IPC: E03D1/30
Filed: 2003-02-13
Abstract: A toilet trip lever assembly (10) provides a lever arm (28) that extends in the tank perpendicular to the tank wall. As an outer handle (20) is rotated, it drives a stem (42), which in turn drives an arm (90) inside the tank that extends parallel to the tank wall, which pushes down an end of a lever (28). A support (26) holds the lever such that downward movement of that end of the lever drives the opposite end of the lever up. The opposite end of the lever is connected to a linkage (18) to a flush valve.
Patent NZ-535782-A (NZ)
Title: Silica based fertiliser
Inventor: CAMPBELL EWAN MALCOLM
IPC: C05D9/00
Filed: 2003-03-04
Abstract: A fertiliser composition, which includes a sea based silica source and an iron source is disclosed, the composition may further includes a calcium source and a paramagnetic source. In preferred embodiments, the silica source is sea mud of a fine powder form, the calcium source is lime, the paramagnetic source is rock dust and the iron source is iron sand. The fertiliser composition has a synergistic effect which facilitates the formation of electric flux lines, and therefore the production of an energy field in the soil. Once the components for the energy field and the electrical flow are established, the ionised elements from the sea based compounds are able to move in the electrical current and, through electrolysis, attract the 'bound up' elements from the soil, thus placing nutrition from the soil into plant available form.
Patent NZ-538111-A (NZ)
Title: Turbine apparatus with pairs of clamshell type blades being opened and closed during rotation
Inventor: NOBLE JAMES D
IPC: F03D11/00
Filed: 2003-08-13
Abstract: A turbine system (10) for capturing energy from a fluid stream includes a torque arm (12). At least a pair of, preferably symmetrical clam shell, turbine blades (14) with the upper (16) and lower (18) halves are oppositely connected to the torque arm (12). A coordinating system (46) is connected to the symmetrical clam shell turbine blades (14). The coordinating system (46) further comprises a first system (48) and second system (52). The first system (48) is connected to control and regulate opening and closing of the upper (16) and lower (18) halves of each individual clam shell turbine blade (14). The second system (52) is connected between each pair of the symmetrical clam shell turbine blades (14) so that as one clam shell turbine blade (14) closes the opposite clam shell turbine blade (14) is forced open.
Patent NZ-539425-A (NZ)
Title: Methods of treating cancer and related methods
Inventor: MACHAJEWSKI TIMOTHY D
IPC: A61K47/26
Filed: 2003-11-12
Abstract: Methods of treating cancer using 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one are provided. In particular, the methods are effective for the treatment of solid tumors or leukemias, including prostate, colorectal, breast, multiple myeloma, pancreatic, small cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, or myelo-proliferative disease. Further provided are methods of measuring the amount of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one and determining a metabolic profile therefore.
Patent NZ-540586-A (NZ)
Title: Product supply and return processing method and system
Inventor: CARTWRIGHT GARRY STEPHEN
IPC: G06Q10/00
Filed: 2005-06-03
Abstract: Computer executable instructions configured to resolve a transaction dispute between a supplier and a buyer are disclosed. The supplier has previously received an order originating from the buyer. The instructions are adapted to execute the steps of: i) presenting the buyer with at least one problem identifier capable of selection; ii) receiving a problem indicator from the buyer on selection of a problem identifier by said buyer; iii) presenting the supplier with at least one resolution action identifier capable of selection; iv) receiving a resolution action indicator from the supplier on selection of a resolution action identifier by said supplier; v) presenting the buyer with a resolution confirmation identifier capable of selection and vi) receiving a resolution confirmation indicator from the buyer. The receipt of a resolution confirmation indicator confirms the resolution of said transaction dispute, and authorises the release of funds.
Patent NZ-542354-A (NZ)
Title: Multilayer structures, packages, and methods of making multilayer structures
Inventor: BLEMBERG ROBERT J
IPC: A23L13/50
Filed: 2004-03-05
Abstract: Multilayer structures, methods of making the same and packages made therefrom are provided. The multilayer structures are useful for packaging bone-in meat or other like products. More specifically, the multilayer structures have sufficient rigidity and strength to contain bone-in meat or other like products. In addition, multilayer structures can easily seal to themselves or to other structures. Moreover, the multilayer structures are biaxially oriented and heat-shrinkable.
Patent NZ-544159-A (NZ)
Title: Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics
Inventor: THOMPSON JOHN E
IPC: A61K38/00
Filed: 2004-06-07
Abstract: Disclosed is an siRNA of apoptosis specific eukaryotic initiation factor 5A (eIF-5A) wherein said siRNA suppresses endogenous expression of apoptosis-specific eIF-5A in a cell and wherein the apoptosis specific eIF-5A is encoded by the nucleotide sequence of SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32 or SEQ ID NO:33. The disclosed siRNA can be mixed with water and administered intranasally as a medicament.
Patent NZ-544367-A (NZ)
Title: Combination therapy involving methotrexate for treating rheumatoid arthritis
Inventor: YEDNOCK THEODORE A
IPC: A61K31/44
Filed: 2004-06-25
Abstract: Disclosed is the use of a combination therapy in the preparation of a medicament for the treatment of rheumatoid arthritis, wherein the combination therapy comprises therapeutically effective amounts of methotrexate and a small molecule alpha-4 integrin antagonist. The small molecule alpha-4 integrin antagonist can be, for example, of formula IA, wherein the substituents are as defined in the specification. Further combinations are claimed in which the compounds can be PEGylated.
Patent NZ-545063-A (NZ)
Title: Use of (-)-5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthol for the treatment of depression
Inventor: SCHELLER DIETER
IPC: A61K31/135
Filed: 2004-07-22
Abstract: Disclosed is the use of rotigotine, also known as (-)-5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino-1-naphthol, a rotigotine prodrug, or a physiologically acceptable salt thereof for treating depression.
Patent NZ-551080-A (NZ)
Title: Compositions isolated from the grasses lolium perenne and festuca arundinacea
Inventor: DEMMER JEROEN
IPC: C12N15/29
Filed: 2006-11-06
Abstract: Provided are isolated polynucleotides from the grass species Festuca arundinacea encoding polypeptides active in the fructan biosynthetic pathway. Further disclosed are expression vectors and host cells comprising such isolated polynucleotides. Methods for the use of such polynucleotides and polypeptides are also provided.