baber/WOPTO huggingface dataset:
Patent CA-3071939-A1 (CA)
Title: Use of gaboxadol in the treatment of diabetes and related conditions
Inventor: DURING MATTHEW
IPC: A61K45/06
Filed: 2018-08-02
Abstract: Methods and compositions for treating a metabolic disease include administering gaboxadol or a pharmaceutically acceptable salt thereof to a patient diagnosed with a metabolic disease. In embodiments, administering gaboxadol or a pharmaceutically acceptable salt thereof to a patient diagnosed with a metabolic disease is effective to lower one or more of HbA1c level, fasting plasma glucose level, 2-hour oral glucose tolerance test (OGTT) result level, and random plasma glucose level. Gaboxadol or a pharmaceutically acceptable salt thereof may optionally be administered in combination with a hypoglycemic agent.
Patent CA-3072016-A1 (CA)
Inventor: LAKHANI SHAKIR
IPC: A61M35/00
Filed: 2018-03-19
Abstract: Provided herein is a water- and sweat-resistant transdermal drug delivery system for application to the skin of a mammal that comprises a patch having a diameter between 1 and 8 cm in length and a surface area between 4 and 8 cm2. Also provided are methods of producing the transdermal drug delivery system and methods of treatment comprising the use of the transdermal drug delivery system.
Patent CA-3075388-A1 (CA)
Inventor: SMITH JOSHUA J
IPC: E21B17/16
Filed: 2018-09-10
Abstract: A double stage drill string stabilizer adapted to condition the well bore and reduce vibrations in the drill string as the device passes thought the well bore is disclosed. The drill string stabilizer comprises a tubular body and at least two stabilizing elements protruding from the exterior of the tubular body. The at least two stabilizing elements are angularly offset from each other around the circumference of the tubular body.
Patent CA-3075961-A1 (CA)
Inventor: BOREL BERNARD
IPC: B65D83/42
Filed: 2018-09-18
Abstract: The invention concerns a stem (1) for a two-way valve, the stem comprising a main body (10) having an external face that is substantially cylindrical about a main axis and having a first tubular wall (11) that is closed at the bottom end of same by a first bottom wall (13) and open at the top end (111) of same, defining a central channel (113); a second tubular wall (12) concentric with the first tubular wall (11) and partially surrounding it, the second tubular wall (12) being closed at the bottom end (122) of same by a second bottom wall (14) and open at the top end (121) of same, defining an annular channel (123) positioned around the central channel (113), one or more through-holes (124) bringing the inside of the annular channel (123) into contact with the cylindrical external face of the main body (10), means for reinforcing the first tubular wall (11) in order to increase the stability of same when filling a container provided with a two-way valve equipped with the stem. According to the invention, the reinforcing means are constituted by a tubular insert (20) dimensioned so as to be able to be inserted into the annular channel (123) and fill, at least over a portion of the height of same, the space situated between the second bottom wall (14) and the lower portion of the through-hole or holes (124) of the second cylindrical wall (12).
Patent CA-3081265-A1 (CA)
Inventor: MAEGLI JACK WILLIAM
IPC: A23L3/3472
Filed: 2018-10-10
Abstract: An antimicrobial powder, which includes a low molecular weight antimicrobial organic acid and a hygroscopic ingredient, is prepared according to a process wherein the components are combined in a solution to form a liquid slurry composition prior to drying to form a powder, such that drying the liquid slurry composition involves co-drying the components. The low molecular weight antimicrobial organic acid in the antimicrobial powder can be present in a crystal phase of both anhydrous and hydrate forms. The antimicrobial powder exhibits excellent properties, such as shelf stability, without the requirement of encapsulating agents. Methods for preparing the antimicrobial powders as well as applications of the antimicrobial powders in food and beverage products are also disclosed.
Patent CA-3083196-A1 (CA)
Inventor: ZANARELLA CLAUDIO ERNESTINO
IPC: B65D77/20
Filed: 2018-11-16
Abstract: Élément de fermeture pour un contenant alimentaire comprenant un stratifié multicouche (1) ayant une première couche (2) de matériau au moins partiellement perméable à la lumière, une deuxième couche (3) de matière plastique, une troisième couche (4) de matériau adhésif repositionnable interposé entre la première couche (2) et la deuxième couche (3), au moins une ligne d'affaiblissement intérieure (102) obtenue sur la deuxième couche (3) et s'étendant selon une géométrie prédéfinie définissant, lors de l'utilisation, un espace d'accès au contenant (200), au moins une ligne d'affaiblissement extérieure (103), obtenue sur la deuxième couche (2), à proximité du bord périphérique (100a) par rapport à la ligne d'affaiblissement intérieure (102) au moins au niveau de la partie de préhension de main, la deuxième couche (3) ayant un motif graphique prédéfini (G) imprimé ou réalisé sur au moins l'une de ses faces (3b).
Patent CA-3084810-A1 (CA)
Title: Compositions and methods for treating disorders of genomic imprinting
Inventor: CHAMBERLAIN STORMY
IPC: A61K48/00
Filed: 2018-12-07
Abstract: Disclosed herein are compositions, kits, and methods for treating a disorder of genomic imprinting in a subject. The method may include modifying a zinc-finger protein 274 (ZNF274) binding site on maternal chromosome 15 at position 15q11-q13 of the subject, such that the binding of a ZNF274 protein to the ZNF274 binding site is reduced relative to a control. The ZNF274 binding site comprises a polynucleotide having at least 90% sequence identify to SEQ ID NO: 1 or SEQ ID NO: 42. Further provided are DNA targeting systems that bind to a ZNF274 binding site or to a gene encoding a ZNF274 protein.
Patent CA-3086143-A1 (CA)
Title: Monitoring wear of double roll crusher teeth by digital video processing
Inventor: POLAK MARK
IPC: B02C25/00
Filed: 2020-07-09
Abstract: A method, related system and related computer program product are provided for monitoring wear of teeth of a drum of a double roll crusher. A processor receives a digital video capturing rotation of the drum and the teeth. For each frame of the digital video, the processor segments the frame into groups of contiguous pixels, wherein each group is representative of one of the teeth. The processor determines parameter indicative of a geometry of at least one of the teeth based on segmented groups of contiguous pixels in at least one of the frames of the digital video. The processor generates a human-readable report based on the parameter indicative of the geometry of the at least one of the teeth.
Patent CA-3086259-A1 (CA)
Inventor: SPETH CHRISTIAN HENRIK
IPC: B01J8/04
Filed: 2018-12-19
Abstract: In a cooled axial flow converter, in which process gas passes from an outer annulus via a catalyst bed, wherein the process gas is converted to a product, to an inner centre tube, the catalyst bed comprises at least one module comprising at least one catalyst layer. Feed means are arranged to provide a flow of process gas from the outer annulus to an inlet part of one or more modules, and collector means are arranged to provide a flow of product stream of converted process gas, which has passed axially down the catalyst bed of one or more of the modules to the centre tube. At least one of the one or more modules comprises one or more cooling plates arranged to be cooled by a cooling fluid.
Patent CA-3086404-A1 (CA)
Title: Systeme de reseau electrique
Inventor: BENNETT ROBERT ROSS
IPC: H02J3/14
Filed: 2019-01-03
Abstract: La présente invention concerne un système qui peut comprendre au moins une partie d'un réseau d'alimentation. Le système peut en outre comprendre un dispositif de commande de charge qui commande un flux de courant avec un niveau de courant de I1 dans un réseau de charge qui fournit de l'énergie à une ou plusieurs charges à partir de ladite partie du réseau d'alimentation selon une courbe de charge préprogrammée. Le système peut également comprendre un système de protection qui isole ladite partie du réseau d'alimentation du dispositif de commande de charge en réponse à la détection d'un motif de courant qui est incompatible avec la courbe de charge préprogrammée.
Patent CA-3091374-A1 (CA)
Inventor: WU WENJUN
IPC: B32B15/092
Filed: 2019-02-18
Abstract: Compounds comprising one or more functionalized fatty acid esters, which may be derived from bio-based oils, are used as a low-VOC coalescent agent (i.e., a coalescent agent having a low content of volatile organic compounds) in waterborne coating compositions. The functional group can be epoxide, vicinal diol, hydroxy phosphotriester, hydroxy ester, hydroxyl alkyl ester, hydroxyl benzyl ester, hydroxy ether, hydroxy amino, hydroxy sulfide, hydroxy nitrile, hydroxy amine, terminal alcohol, thiiran, ketone, or cyclic carbonate. The present disclosure also relates to waterborne coating compositions comprising these functionalized fatty acid esters.
Patent CA-3091793-A1 (CA)
Inventor: ECKMAN JEFFREY M
IPC: G06Q10/00
Filed: 2019-02-21
Abstract: A system for providing a visual display of a visitor's journey pathways through various digital touchpoints and quantitative measurements of the visitor's interaction with each digital touchpoint includes an online visitor meta-data database, an online images database, a visitor journey analytics code, a visitor journey analytics engine, a computing system, and a user interface. The visitor journey analytics code is embedded in each digital touchpoint and the visitor journey analytics code extracts visitor meta-data associated with each digital touchpoint that a visitor visits and uploads them to the online visitor meta-data database. The visitor journey analytics engine includes a customer journey analytics processing software product that receives visitor meta-data and specific online images for each digital touchpoint a visitor visits, calculates a visitor experience performance index for each digital touchpoint, and records visitor's journey pathways through various digital touchpoints. The user interface displays the visitor's journey pathways through the various digital touchpoints and the calculated visitor experience performance indexes for each digital touchpoint.
Patent CA-3092325-A1 (CA)
Title: Vehicle safety systems and methods
Inventor: OHANA AVRAHAM
IPC: H04W4/40
Filed: 2019-02-14
Abstract: Vehicle safety systems may include a tag reader, a control unit, and an application executable on a mobile communication device. The tag reader attaches to a mounting mechanism deployed within a vehicle, and reads a tag attached to the mobile communication device in response to mounting the mobile communication device to the mounting mechanism. The control unit receives a verification signal from the tag reader in response to reading of the tag by the tag reader, and sends an activation signal to the mobile communication device in response receipt of the verification signal. The application switches operation of the mobile communication device from a first operational mode to a second operational mode by disabling touchscreen operation and enabling voice command operation in response to receipt of the activation signal by the mobile communication device.
Patent CA-3092778-A1 (CA)
Inventor: MACKAY ALEXANDER CRAIG
IPC: E21B17/10
Filed: 2019-04-15
Abstract: A centraliser for use in a wellbore includes: first and second collars, at least one resilient device extending between the first and second collars, and a locking ring for receiving a tubular in a position radially inside the resilient device and axially between the first and second collars; the resilient device being resiliently biased in a radial direction away from the locking ring; the locking ring having at least one catch device adapted to engage with the at least one resilient device in a radially restricted configuration and the catch device is adapted to resist radial movement of the resilient device away from the locking ring when the catch device is engaged with the resilient device; and at least one fixing between the at least one catch device and the locking ring and made from a sacrificial material adapted to degrade in wellbore conditions.
Patent CA-3094512-A1 (CA)
Inventor: LONG LIONEL C
IPC: E01H10/00
Filed: 2020-09-25
Abstract: A motor shaft seal assembly configured to prevent external elements from entering internal portions of a motor housing of a motor through a motor shaft seal is provided. The motor shaft seal assembly includes a seal plate configured to mount to a motor. The seal plate has a seal aperture configured to encircle a motor shaft of the motor. An inlet port is mounted to the seal plate. An internal passage extends from the inlet port, through the seal plate, to a plurality of annular cavities positioned proximate the motor shaft. A supply of a flexible sealing compound is provided to the plurality of annular cavities in a manner such as to contact the motor shaft, thereby forming an additional barrier to prevent external elements from entering internal portions of the motor through the motor shaft seal.
Patent CA-3094859-A1 (CA)
Inventor: LEWIS JOHN DAVID
IPC: C12N15/10
Filed: 2020-10-01
Abstract: Lipid nanoparticle (LNP) delivery platforms have undergone incremental improvements, but still suffer from cellular toxicity and a biodistribution profile limited to hepatic cells.  We developed an all-encompassing proteolipid nucleic acid delivery vehicle formulated with a chimeric FAST protein, called Fusogenix. Using this approach, we demonstrate that ionizable lipids can be utilized at a minimal molar ratio for the sole purpose of neutralizing the anionic charge of nucleic acids, rather than facilitating endosomal escape. Incorporation of this chimeric FAST protein into a PLV  platform enhances intracellular delivery and expression of mRNA and pDNA both in vitro and in vivo. These PLVs also display a favorable immune profile and are significantly less toxic than conventional LNPs. Gene therapy holds great promise to treat a wide array of diseases but has struggled to gain widespread regulatory approval primarily due to the lack of a safe and effective nucleic acid delivery platform that is non-immunogenic, easy to manufacture, and able to achieve systemic biodistribution. To overcome the limitations surrounding viral and non-viral vectors we combined the positive aspects of both platforms to develop a proteolipid vehicle (PLV) that can achieve efficient nucleic acid gene expression with high tolerability. We developed a library of chimeric fusion-associated small transmembrane (FAST) proteins and identified the FAST protein with a superior ability to facilitate plasma membrane fusion. Inclusion of the chimeric FAST protein into the PLV platform enables a minimal molar ratio of ionizable lipids to be utilized for the sole purpose of neutralizing the anionic charge of nucleic acids. Expression of both messenger RNA (mRNA) and plasmid DNA (pDNA) is improved following FAST  incorporation.  Systemically administered FAST-PLVs displayed an extensive biodistribution to all organs tested, with pDNA and mRNA inducing robust gene expression in the lungs, liver, spleen, and kidney. FAST-PLVs display a favorable immune profile and can be repeatedly dosed without losing activity. The increased safety of FAST-PLVs, even at high doses allows for comparable nucleic acid expression to conventional lipid nanoparticles with substantially less toxicity, making them an excellent clinical candidate for gene therapy approaches.
Patent CA-3095122-A1 (CA)
Inventor: GURTNER GEOFFREY C
IPC: A61P35/00
Filed: 2019-03-27
Abstract: L'invention concerne un timbre transdermique pour le traitement d'ulcères de la drépanocytose. Le timbre peut faciliter l'administration d'un chélateur du fer, tel que la DFO. La DFO peut être encapsulée dans une micelle inverse pour améliorer la pénétration et l'absorption par le derme. Le timbre peut être utilisé pour accélérer la cicatrisation et réduire la douleur associée aux ulcères de la drépanocytose.
Patent CA-3096855-A1 (CA)
Title: Control of evaporation in digital microfluidics
Inventor: JEBRAIL MAIS JEHAN
IPC: B01L3/00
Filed: 2019-05-23
Abstract: Air-matrix digital microfluidics (DMF) apparatuses and methods of using them. These methods and apparatuses may include the use of a liquid wax coating material and/or pinning the encapsulated reaction droplet within the air gap using pinning features. Any of these methods may also include separating the liquid wax from an encapsulated aqueous droplet, e.g., using an oil absorbent wick to selectively separate the liquid oil or wax from the aqueous droplet by adsorbing and/or absorbing the liquid wax into the absorbent wick while leaving the aqueous droplet behind.
Patent CA-3098842-A1 (CA)
Title: Centralized parking guidance system
Inventor: SEBASTIAN MANOJ
IPC: G08G1/14
Filed: 2020-11-12
Abstract: Centralized parking guidance system for monitoring multitude of parking facilities which are distributed in different geographical locations. Plurality of Imaging devices(cameras) are placed at different locations within the parking facilities. These imaging devices(cameras) are constantly transferring images to central image processing service. Central Image processing service will process incoming images & detect vacant parking spaces in parking facilities. The availability of underlying parking spaces is communicated to customers through various communication mediums as visual display as well as voice notifications.
Patent CA-3100255-A1 (CA)
Title: Procede et dispositif de conversion d'une image bidimensionnelle en image tridimensionnelle, et systeme d'imagerie tridimensionnelle
Inventor: ZHANG YI
IPC: H04N5/265
Filed: 2019-05-06
Abstract: L'invention concerne un procédé et un dispositif de conversion d'une image bidimensionnelle en une image tridimensionnelle, et un système d'imagerie tridimensionnelle. Le procédé consiste à : obtenir une image bidimensionnelle à traiter; effectuer une transformation en perspective sur l'image bidimensionnelle, de façon à obtenir respectivement une image d'oeil gauche et une image d'oeil droit; en fonction du résultat de la transformation en perspective, ajuster une distance entre l'image d'oeil gauche et l'image d'oeil droit; et combiner les images d'oeil gauche et d'oeil droit dont la distance a été ajustée. Dans des modes de réalisation de l'invention, une transformation de perspective est réalisée sur une image bidimensionnelle à traiter, de façon à créer des images de parallaxe binoculaire, et effectuer un ajustement de distance sur les images d'oeil gauche et d'oeil droit transformées en perspective, de façon à former un angle de convergence de création de parallaxe binoculaire, de sorte que des images observées par l'oeil nu présentent des profondeurs différentes qui permettent une visualisation de effets différents 3D. La transformation d'une image sur une image bidimensionnelle, qui n'est pas liée à la résolution et à la clarté de l'image, peut rendre la qualité d'images prises en 3D identique à celle de l'image bidimensionnelle originale, sans inconvénient pour un effet d'imagerie 3D.
Patent CA-3100349-A1 (CA)
Inventor: GARCIA KENAN CHRISTOPHER
IPC: C07K16/28
Filed: 2019-05-16
Abstract: Disclosed herein are compositions and methods for modulating cell surface receptor signaling by specifically recruiting membrane phosphatases to a proximity of receptors of interest. This novel methodology, termed Receptor Inhibition by Phosphatase Recruitment (RIPR), represents a new approach to reducing and suppressing signal by receptors that signal through phosphorylation mechanisms. More particularly, the disclosure provides novel multivalent protein-binding molecules that specifically bind a cell surface receptor and antagonize the receptor signaling through recruitment of a phosphatase activity. Also provided are compositions and methods useful for producing such molecules, as well as methods for the treatment of diseases associated with the inhibition of signal transduction mediated by cell surface receptor.
Patent CA-3102291-A1 (CA)
Title: Systeme de filtration d'air pour moteur a combustion et moteur a combustion le comprenant
Inventor: DUMAIS DENIS
IPC: B01D46/42
Filed: 2019-06-07
Abstract: La présente invention concerne un système de filtration d'air comprenant un boîtier de filtre définissant une chambre de collecte et comprenant une entrée d'air, une sortie d'air et une ouverture d'ensemble de nettoyage en communication fluidique avec la chambre de collecte. Le système comprend également un support de filtre monté sur le boîtier de filtre, chaque entrée d'air et la sortie d'air étant situées sur un côté respectif du support de filtre; et un ensemble de nettoyage de filtre monté sur le boîtier de filtre et comprenant un système d'actionnement; et un ensemble diaphragme recouvrant au moins partiellement l'ouverture de nettoyage de filtre. L'ensemble diaphragme vibre lors de l'actionnement du système d'actionnement de façon à déplacer l'air dans la chambre de collecte pour éliminer la matière particulaire d'un filtre en prise avec le support de filtre. La présente invention concerne également un moteur à combustion comprenant un système de filtration d'air et un procédé de nettoyage d'un système de filtration d'air.
Patent CA-3103554-A1 (CA)
Inventor: VITNER OFER
IPC: G08C19/00
Filed: 2019-06-11
Abstract: Systems and methods for testing a test sample obtain a first image of the test sample via a first input device. The first input device is a primary camera configured to capture the first image while a plurality of light sources illuminate the test sample. The first image is sent from the first input device to a control panel. The control panel is used to label a plurality of layers on the first image. A water cut of the test sample is determined based on labeling of plurality of layers of the first image.
Patent CA-3107473-A1 (CA)
Title: Ultrasound image acquisition optimization according to different respiration modes
Inventor: CANNON MICHAEL G
IPC: A61B5/08
Filed: 2021-01-29
Abstract: Embodiments of the present invention provide a method, system and computer program product for ultrasound image acquisition optimization according to different respiration modes. A method for ultrasound image acquisition optimization according to different respiration modes includes acquiring by an ultrasound imaging device, an ultrasound image of a target organ. The method further includes comparing attributes of the acquired ultrasound image to association data in a data store of associations associating attributes of previously acquired ultrasound imagery of different images of the target organ with different modes of respiration. Finally, the method includes determining from the comparison, a mode of respiration evident from the acquired ultrasound image and presenting the determined mode in the ultrasound imaging device.
Patent CA-3109109-A1 (CA)
Inventor: YU JIANHUA
IPC: A61K35/76
Filed: 2018-08-09
Abstract: The disclosure provides oncolytic herpes virus comprising a heterologous gene encoding E-cadherin. The disclosure further provides pharmaceutical compositions that comprise such oncolytic herpes virus, and methods of treatment using such oncolytic herpes virus.