Patent SG-11201909443Y-A (SG)
Title: Compounds and methods for treating bacterial infections
Inventor: COMITA-PREVOIR JANELLE
IPC: A61P31/04
Filed: 2018-05-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT omit °nolo His mom ono iflo oimIE (10) International Publication Number WO 2018/208769 Al N GC O 00 O 1-1 R4 R5 Y . N—N X 6 R (51) International Patent Classification: A61K 31/439 (2006.01) A61P 31/04 (2006.01) C07D 471/08 (2006.01) (21) International Application Number: PCT/US2018/031593 (22) International Filing Date: 08 May 2018 (08.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/502,867 08 May 2017 (08.05.2017) US (71) Applicant: ENTASIS THERAPEUTICS, INC. [US/US]; 35 Gatehouse Drive, Waltham, MA 02451 (US). (72) Inventors: COMITA-PREVOIR, Janelle; 11 Prospect Street, Northborough, MA 01532 (US). DU- RAND-REVILLE, Thomas, Francois; 34 Birch Hill Road, Belmont, MA 02478 (US). GULER, Satenig; 35 Gatehouse Drive, Waltham, MA 02451 (US). ROMERO, Jan; 8 Langley Road, Arlington, MA 02474 (US). SYLVESTER, Mark; 35 Gatehouse Drive, Waltham, MA 02451 (US). TOMMASI, Ruben; 16 Salamander Lane, Stow, MA 01775 (US). VELEZ-VEGA, Camilo; 35 Gate- house Drive, Waltham, MA 02451 (US). WU, Xiaoyun; 3 Hundreds Road, Westborough, MA 01581 (US). ZHANG, Jing; 11 Run Brook Circle, Sudbury, MA 01776 (US). (74) Agent: DAVIS, Steven, G. et al.; McCarter & English, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) 1; (54) Title: COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS (57) : Provided herein are antibacterial compounds represented by Formula I, or a phar- maceutically acceptable salt thereof, wherein X, Y, R 4 , R 5 , and R 6 are as defined herein. Also provided are pharmaceutical compositions comprising the compounds of Formula I. 0 uok..)3H C