baber/WOPTO huggingface dataset:
Patent NO-334317-B1 (NO)
Inventor: LUPTON DAVID FRANCIS
IPC: F23L7/00
Filed: 2002-01-10
Abstract: A process and a device for reducing the nitrous oxide which is formed during the catalytic combustion of ammonia and oxygen to form nitrogen oxides. A catalyst system including at least one first catalyst mesh element and at least one second catalyst mesh element is used for the catalytic combustion of ammonia and oxygen to form nitrogen oxides, where the minimum of one first catalyst mesh element is a platinum-rhodium mesh and the minimum of one second, downstream catalyst mesh element is a palladium-rhodium mesh with 2-4 wt. % of rhodium.
Patent NO-333730-B1 (NO)
Title: Metode og apparat for a male akkumulert og instantanrate av materialreduksjon og -okning
Inventor: NIELSEN KAJ VENDELBO
IPC: G01B7/06
Filed: 2002-05-28
Abstract: Oppfinnelsen omhandler en metode og en apparatur for å måle akkumulert og instantanrate til materialtap eller materialøkning til metallelementer for deteksjon av metallavsetting forårsaket f.eks. under avsetting av belegg brukt i platingsprosesser og korrosjon forårsaket f.eks. i rørledninger under transport av farlige media. Dette gjøres ved å innsette en probe i måleomgivelsene som sørger for at proben opplever metallavsetting eller korrosjon. Apparaturen og metoden tilveiebringer anordninger for å måle akkumulert og instantanrate til materialetap eller materialøkning ved å innføre en sonde i måleomgivelser slik at sonden utsettes for metallavsetting eller korrosjon. Ytterligere tilveiebringer apparaturen og metoden anordninger for å utføre en temperaturuavhengig måling av akkumulert og instantanrate til materialtap eller materialøkning utført uten anvendelse av en temperatursensoranordning.
Patent NO-325462-B1 (NO)
Inventor: KOCH ANETTE GRANLY
IPC: A23L13/60
Filed: 2003-07-17
Abstract: The invention relates to a method for production of sliced pieces of food, in which a piece of food (3) is cut into slices (8) in a slicer (1) by repetitive cuttings of the piece of food. During the slicing, a preparation inhibiting pathogens (12,16) is being added onto the cut off slice surfaces that occur during the slicing of the piece of food, using one or more noz-zles (9,13). Sufficient amounts of a preparation inhibiting the development of pathogenic germ cells, e.g. listeria organisms, are automatically added onto the surface of the slices. The product thus becomes safe to use after having been stored for a considerable amount of time at fridge temperature.
Patent NO-326330-B1 (NO)
Inventor: EDLING KENNETH
IPC: A47C/
Filed: 2006-11-24
Abstract: A spring mattress is described, including a plurality of strings interconnected side by side. Each string includes a plurality of continuous casings and, enclosed therein, coil springs. Moreover, between at least some of the springs in at least one of the strings a slot is arranged which opens towards the upper or lower side of the mattress. It is preferred for the springs between which the slot is arranged to be separated with an intermediate separation distance, which separation distance exceeds about 10% of the diameter of the largest turn of the adjoining springs. In addition, it is preferred for the casing portions to be arranged at the ends of the spring to be moved towards each other, through the spring, and connected to each other by at least one connecting device.
Patent NO-327839-B1 (NO)
Title: Fremgangsmate ved fremstilling av trepellets og pellets derav
Inventor: GRONN ARNE JOHANNES
IPC: C10L5/44
Filed: 2008-12-15
Abstract: Det er tilveiebrakt en fremgangsmåte ved fremstilling av trepellets av materiale omfattende trevirke i form av flis eller liknende partikler. Fremgangsmåten omfatter å: føre materialet, dersom det har en relativ fuktighet over 20 masse-%, til et tørketrinn og tørke det til en relativ fuktighet på 0-20 masse-%; føre materialet, eventuelt via et mellomlagringstrinn, til et varmebehandlingstrinn og oppvarme materialet til 180-235 °C ved tilførsel av damp i en reaktor; holde materialet i reaktoren ved den oppnådde temperaturen i en tilstrekkelig tid til å mykne materialet og frigjøre ligning; avlaste trykket i reaktoren i minst ett trinn; og pelletere det behandlede materialet, eventuelt etter at det er blandet med trevirke.
Patent NO-340637-B1 (NO)
Inventor: PETERSEN LARS BØRTHY
IPC: E04D1/28
Filed: 2009-01-08
Abstract: The invention relates to a method for impregnation of porous objects comprising the following steps i)-v): i) applying an injection layer of a material comprising acrylic, epoxy or polyurethane onto the surface of at least part of the porous object and allowing at least part of said material to enter into the pores of said object utilising subatmospheric or superatmospheric pressure; ii) allowing the porous object to return to an atmosphere of normal pressure; iii) optionally at least partly allowing the injection layer to harden; iv) applying a topcoat of acrylic, epoxy or polyurethane onto the area of the porous object impregnated with the injection layer: v) allowing the topcoat to harden; wherein the injection layer applied in step i) and/or the topcoat applied in step iv) comprises pulverised glass having a particle size of 0 run to 100 mum. The invention also relates to porous objects obtained according to this method. The impregnated objects exhibits great strengths and resistance against wear of mechanical, chemical, thermal and/or biological nature.
Patent NO-329763-B1 (NO)
Title: Fremgangsmate for provetaking og analyse av produksjon fra en undervannsbronn for maling av saltinnhold i produsert vann samt volumforhold mellom vaeskefraksjonene
Inventor: ERIKSEN EGIL
IPC: B01D17/00
Filed: 2009-05-09
Abstract: Oppfinnelsen er et permanent undervanns prøvetakings- og analysesystem (1) som typisk integreres i en utskiftbar utstyrsmodul for en undervanns produksjonsbrønns strupeventil (2). Analysesystemet separerer prøven i væskefraksjoner bestående av råolje, kondensat og produsert vann og måler saltinnholdet i vannet, samt volumforholdet mellom væskefraksjonene. Med dette utstyret blir det mulig med jevne mellomrom å følge med på utviklingen i saltinnholdet i det produserte vannet fra en enkelt brønn uten å forstyrre produksjonen fra brønnen. Informasjonen fra analysesystemet kan brukes til å oppdatere kalibrer!ngsoppsettet for brønnens flerfase- strømningsmåler, avsløre eventuelt vanngjennombrudd fra vanninjeksjon i reservoaret, eller for annen reservoaranalyse. På grunn av at analyseutstyret blir permanent installert på undervanns brønnutstyret, unngås kostnader ved prøvetaking via intervensjonsoperasjoner fra fartøy, eller at man midlertidig må stenge ned produksjon fra andre brønner som produserer til en felles undervannsmanifold for å undersøke hvilken brønn som eventuelt har fått vanngjennombrudd.
Patent NO-333286-B1 (NO)
Title: Anordning ved transportabelt rormagasin
Inventor: LUNDE OLA
IPC: E21B19/08
Filed: 2009-07-29
Abstract: Anordning ved transportabelt rørmagasin (1) for anvendelse i en borerigg (10) hvor rørmagasinet (1) omfatter en ramme-konstruksjon (2) med langsider (4) og endepartier (6, 8), idet rørmagasinet (1) er innrettet til å romme to eller flere rør (14), og hvor rør (14) som er lagret i rørmagasinet (1) har sin lengdeakse (16) i stående retning når rørmagasinet (1) befinner seg i sin bruksstilling i boreriggen (10).
Patent NO-342889-B1 (NO)
Inventor: VÅGSHOLM ERLEND
IPC: G01V1/38
Filed: 2017-02-24
Abstract: Divisible spacer(10) and method for assembling structure components, such as strength members (110) and conductor bundle (100), of a marine seismic streamerenabling automated assembly of the structure components of the marine seismic streamer.
Patent PL-91850-B1 (PL)
IPC: F16H57/023
Filed: 1974-10-02
Abstract: A horizontal load shaft, projecting from a gear housing, is driven from a hydrostatic motor via a bevel pinion meshing with a bevel gear fixed to the shaft inside the housing. The motor and the bevel pinion form a unit detachably mounted on the gear housing, with the bevel pinion projecting inwardly from above.
Patent PL-157505-B1 (PL)
Title: Method and device for determination of the density dynamics of soil profile
IPC: E02D1/00
Filed: 1988-04-22
Abstract: 1. The method for determination of soil profile density dynamics, consisting in measuring distances between the levels delimiting measurement strata, consisting in that the surface indicator (1) is positioned on the surface of tested soil, and at the distance of not more than the length of the flexible cable (2) of the measuring device the bench-mark (3) is mounted in the protecting tube (4) at the depth larger than the levels delimiting soil measurement strata, with in-ground indicators (5) placed in them, the control stand (6) of the measuring device is placed on the bench-mark (3), and the measuring stand (7) on the successive tips of the surface (1) and in-ground (5) indicators, reading the differences of the indications of the column of liquid, then after the readings in the last measurement cycle soil density is determined by commonly used methods, and after that on the basis of the determined density and changes in the thickness of the measurement strata its is calculated on the basis of the known proportion of soil density at each time of the measurement.<IMAGE>
Patent PL-158784-B1 (PL)
Title: Coal cleaning method
IPC: B03B1/04
Filed: 1988-12-14
Abstract: A process is disclosed for beneficiation of coal by selective caking, in which process a caking mixture is employed consisting of: - one or more solvents selected among the light hydrocarbons having boiling points not higher than 70 DEG C; - one or more non-ionic additives selected among oil-soluble propoxylated or propoxylated-ethoxylated phenolic or alkylphenolic compounds; - possibly one or more heavy co-caking agents selected among coal-derived oils having boiling points between 200 DEG C and 400 DEG C, or the residual products of petroleum refining, or mixtures thereof.
Patent PL-162711-B1 (PL)
Title: Low-zinc agent for phosphate coating of steels
Inventor: KOLANKOWA HANNA
IPC: C23C22/07
Filed: 1990-04-13
Abstract: Low-zinc contents agent for phosphatising steel surfaces, being an aqueous solution based on the phosphate ions PO43-, zinc Zn2+, nickelous Ni2+, nitrate NO3 and sodium Na+, with the proportion of zinc to phosphate ions computed to P2O5 representing less than 0.125 by weight, characterised in that contains the following volumes of ions computed to P2O5: 240-290 g/dm<3> of PO43- ions , 24-28 g/dm<3> Zn2+ ions , 22-30 g/dm <3> Ni2+ ions , 05-21 g/dm<3> Na+ ions , 25-55 g/dm<3> NO3- ions , with the proportion of zinc to phosphate ions computed to P2O5 representing from 0.083 to 0.117 by weight, and additionally contains 14-20 g/dm<3> ions of Mn2+ as well as sulfone derivative with general formula Ar-SO3H, where Ar denotes benzene ring or such ring substituted by the methylene and/or ethylene group, or denotes naphthalene ring or such ring substituted by methylene and/or ethylene group and/or alkaline metals salts derivatives in volumes from 0.02 molar/dm<3> to 0.2 molar/dm <3>.<IMAGE>
Patent PL-165793-B1 (PL)
Inventor: SWIATKOWSKA MARIA
IPC: C12P21/04
Filed: 1990-04-25
Abstract: 1. Sposób wytwarzania polipeptydu,zdolnego do produkcji przeciwciał reagujących
specyficznie z białkiem ludzkiego inhibitora tkankowego aktywatora plazminogenu i tym
polipeptydem i/lub reagującego specyficznie z przeciwciałami dla inhibitora tkankowego
aktywatora plazminogenu, oraz z przeciwciałami dla tego polipeptydu, znamienny tym, ze
DNA kodujące polipeptyd odpowiadający fragmentowi o wzorze (Y)a-A-(Z)b, w którym Y
oznacza sekwencję aminokwasów kodowaną przez fragment polilinkera, korzystnie Glu, Ser;
a = 0 lub 1; Z oznacza sekwencję Glu, Ser i/lub sekwencję kodowaną przez fragment
polilinkera; b = 0,1 lub 2; natomiast A oznacza sekwencję odpowiadającą fragmentowi
Asn,i72-Thr232 ludzkiego inhibitora tkankowego aktywatora plazminogenu, łączy się z wektorem
ekspresyjnym, zrekombinowanym wektorem transformuje się komórki gospodarza
bakteryjnego, które hoduje się i wyodrębnia z nich białko.
Patent PL-163694-B1 (PL)
Inventor: ARCISZEWSKI JANUSZ
IPC: B25D1/04
Filed: 1990-09-24
Abstract: Narzędzie do wbijania gwoździ zawierające
końcówkę wbijającą i uchwyt z magazynkiem łączone
rozłącznie, znamienne tym, że cylindrycznakońcówka
wbijająca (1) zakończona jest z jednej strony
uchwytem cylindrycznym (2) z dwoma występami (3)
odpowiadającym; wgłębieniom (4) w gnieździe
uchwytu (5), z drugiej strony roboczej ma otwór nieprzelotowy
(6) skierowany prostopadle do osi końcówki
wbijającej (1) o średnicy większej od średnicy
łba gwoździa wbijanego, oraz w osi końcówki wbijającej
(1) ma cylindryczne gniazdo (7) o takiej samej
średnicy łączące się z otworem nieprzelotowym (6), a
ponadto z drugiej strony między otworem nieprzelotowym
(6) i czołową płaszczyzną (8) w płaszczyźnie
osi otworu nieprzelotowego (6) i osi końcówki wbijającej
(1) jest szczelina (9) o szerokości większej od
średnicy szpilki gwoździa, której dno stanowi półcylinder
(10) otworu o tej samej średnicy co szerokość
szczeliny (9) znajdujący się w osi końcówki wbijającej
(1).
Patent PL-164397-B1 (PL)
Inventor: CHELMICKA GENOWEFA GRAZYNA
IPC: A61K39/04
Filed: 1991-05-24
Abstract: Sposób wytwarzania szczepionki przeciwgronkowcowej i uodporniającej z hodowanych
szczepów bakteryjnych gronkowców, paciorkowców, pałeczek Gram(+) i Gram (-) z zastosowaniem
formalinyjako konserwanta, znamienny tym, że hoduje się wyselekcjonowane szczepy
bakteryjne zawierające 35 - 55 części wagowych bakterii Staphylococcus Aureus, 0-5 części
wagowych bakterii Staphylococcus Saprophiticus, 10 - 50 części wagowych bakterii Streptococcus
Speciens, 10 - 40 części wagowych bakterii Branhamella Catarrhalis, 8-40 części wagowych
bakterii Corynebacterium Pseudodiphteriae, 10-50 części wagowych bakterii Haemophilus
Influenzae oraz 2-10 części wagowych drożdżakówCandida Speciens, następnie zawiesza się je
w roztworze soli fizjologicznej o stężeniu 0,85 - 0,9% NaCl i dodaje 3 - 4% formaliny, po czym tak
przygotowany roztwór poddaje się inkubacji w czasie 48 - 72 godzin, następnie odwirowuje się,
przemywa osad i ewentualnie powtarza się etap konserwacji, odwirowania i przemycia osadu, a
po kontrolijałowości i toksyczności preparatu przygotowuje się szczepionkę przez zawieszenie w
wodzie dejonizowanej.
Patent PL-167771-B1 (PL)
Title: Cigarette
Inventor: MOLLOY PETER J
IPC: A24D1/00
Filed: 1991-10-25
Abstract: A smoking article comprising a rod of smoking material (1) and a filter portion, said filter portion including means (6) for collecting particulate matter in the smoke from the rod of smoking material in a collection zone (7), and means (3) for heating said collection zone to release the semivolatile compounds whilst allowing the involatiles to be retained in the filter. <IMAGE>
Patent PL-171156-B1 (PL)
Inventor: AOKI YUHKO
IPC: C07D521/00
Filed: 1992-07-23
Abstract: 1 . Sposób wytwarzania nowych pochodnych cykloheksanu i tetrahy- dropirajiu o wzorze 1, w którym X oznacza grupe -O- lub -CH 2-, R oznacza grupe -Y-alkilowa, -Y-aryloalkilowa lub -Y-arylowa, gdzie Y oznacza grupe -O-, NHCO-, -(CH=CH)n-, przy czym n równe jest O lub 1, -CH 2O- lub CH 2S, a alkil w grupie -Y-alkilowej oznacza grupe alkilowa o prostym lub rozgalezionym lancuchu, zawierajaca 1-15 atomów wegla, alkilen miedzy Y 1 grupa arylowa w ugrupowaniu Y-aryloalkil oznacza grupe alkilenowa zawierajaca 1 - 5 atomów wegla, aryl w ugrupowaniu -Y-ary 1 oraz Y-aryloalkil oznacza grupe fenylowa, naftylowa, pirydylowa, chinolilowalub chmoksalinylowa, przy czym grupy te moga byc podstawione jednym lub wiecej atomami chlorowca, grupami hydroksylowymi, grupami alkilowymi, chloro- wcoalkilowymi, alkoksylowymi, aminowymi lub dialkiloaminowymi, w których grupy alkilowe stanowia nizsze grupy alkilowe oznacza atom wodoru lub grupe hydroksylowa, R oznacza grupe 1H-imidazol-1-ilometylowa lub 1H-1,2,4-tnazol-l- ilometylowa,4 kazdy z R4 i R5 oznacza niezaleznie atom wodoru, nizsza grupe alkilowa, alkoksylowa lub alkilotio, R oznacza atom wodoru, nizsza grupe alkilowa, alkoksylowa lub alkilo- tio, aminowa, nizsza grupe alkiloaminowa lub dialkiloaminowa, R oznacza atom wodoru, grupe hydroksylowa, nizsza grupe alkilowa, alkoksylowa lub alkilotio, która moze byc ewentualnie podstawiona grupa hydroksylowa, alifatyczna grupa acylowa o 1 - 4 atomach wegla lub arylowa, R 1 R4 wziete moga tworzyc wiazanie pojedyncze, oraz ich farmaceutycznie dopuszczalnych soli, znamienny tym, ze poddaje sie reakcji zwiazek o wzorze ogólnym 2, w którym R 2 oznacza atom wodoru albo R2 i R tworza razem wiazanie pojedyncze, a R1 ,R 4 ,R 5 ,R 6 ,R 7 oraz X maja znaczenie podane wyzej, a chlorkiem metanosulfonylu, chlorkiem p-toluenosulfonylu lub bezwodnikiem tnfluorometanosulfono- wym, po czym na uzyskany metanosulfonian, p-toluenosulfonian lub tri- fluorometanosulfonian dziala sie sola metalu alkalicznego imidazolu lub 1H -1,2,4-tnazolu W zór 1 W zór 2 PL PL PL PL PL
Patent PL-173037-B1 (PL)
Inventor: IMWINKELRIED RENE
IPC: C07C205/12
Filed: 1993-05-12
Abstract: 1. Sposób wytwarzania 5-chloroksindolu o wzorze 1, znamienny tym, ze w pierwszym etapie chloronitrobenzen o wzorze 2 za po- moca estru alkilowego kwasu chlorooctowe- go o ogólnym wzorze 3, w którym R oznacza grupe C -C 7 -alkilowa, rozgaleziona albo nierozgaleziona, w obecnosci zasady prze- prowadza sie w ester alkilowy kwasu chloro- nitrobenzenooctowego o ogólnym wzorze 4, w którym R ma podane znaczenie, który w drugim etapie poddaje sie uwodornieniu katalitycznie za pomoca wodoru do odpo- wiedniej aminy o ogólnym wzorze 5, w któ- rym R ma podane znaczenie, i te nastepnie w trzecim etapie w obecnosci kwasu cyklizuje sie do produktu koncowego o wzorze 1. PL PL PL
Patent PL-170708-B1 (PL)
Title: Method of decomposing hydrocarbons
Inventor: LYNUM STEINAR
IPC: C09C1/52
Filed: 1992-12-11
Abstract: In a method for decomposition of hydrocarbons for the production of hydrogen and carbon black, the feed stock is passed through a plasma torch, which causes a pyrolytic decomposition of the feed stock. The feed stock is transported through the plasma torch (A) in a cooled lead-in tube (1) and undergoes a first heating in an area in the immediate vicinity of the plasma flame. The material thereby produced is passed on to one or more subsequent stages where the final and complete decomposition of the hydrocarbons to carbon black and hydrogen occurs. In this area further raw material may be added which causes quenching and reacts with the already produced carbon black. An increase is thereby caused in particle size, density and amount produced without further energy supply, whereafter the products produced are expelled and separated and hot gas may be transported in a return pipe to the torch, in order to further increase the energy yield.
Patent PL-180683-B1 (PL)
Inventor: POLTARZEWSKI ZBIGNIEW
IPC: H01M8/10
Filed: 1995-06-23
Abstract: Sposób wytwarzania membrany protonowo przewodzącej, w którym polimery zawierające
heteroatomy miesza się ze środkiem żelującym i rozpuszczalnikiem, wylewa się na
płaskąpowierzchnię i usuwa się rozpuszczalnik, znamienny tym, że akryloamid i N,N'-metyleno-bis-akryloamid
w ilości 0,001 -0,1 g na 1g akryloamidumiesza się ze środkiem żelującym,
którymjest agar-agar w ilości 0,05-0,5 g na 1 g akryloamidu, dodaje się wody destylowanej w
ilości 10-15 g na 1g akryloamidu i 30% wody utlenionejjako katalizatoraw ilości 0,002-0,005 g
na 1 g akryloamidu, po czym mieszaninę polimeryzuje się w temperaturze 70-80°C przez
0,5-1,5 h, a następnie dodaje się 0,1-5 g na 1 g akryloamidu stężonego kwasu siarkowego,
mieszaninę wylewa się na płaską powierzchnię 1 polimeryzuje się w temperaturze 70-80°C
przez 20-60 minut, a następnie mieszaninę żeluje się w temperaturze pokojowej, po czym odparowuje
się nadmiar rozpuszczalnika.
Patent PL-173913-B1 (PL)
Title: Dispenser for solid therapeutic agents
Inventor: ESSIG DIETER
IPC: B65D83/04
Filed: 1994-06-03
Abstract: PCT No. PCT/EP94/01796 Sec. 371 Date May 28, 1996 Sec. 102(e) Date May 28, 1996 PCT Filed Jun. 3, 1994 PCT Pub. No. WO94/29191 PCT Pub. Date Dec. 22, 1994A new dispenser for solid pharmaceutical preparations consists of a flat container with a removal well 3 which can be closed or opened by the flipping round of a closure member 5 with a convexity 6 engaging in the removal well 3.
Patent PL-191920-B1 (PL)
Title: Stell for making forgings of bainitic structure, method of making such forging and forging obtained thereby
Inventor: PICHARD CLAUDE
IPC: C22C38/58
Filed: 1996-11-27
Abstract: Steel for forging comprises by weight 0.05-0.12 (0.05-0.08)%, carbon, 0.1-0.45 (0.15-0.35)% Si, 1.01-1.8 (1.01-1.35)% Mn, 0.15-1.15 (0.8-1.15)% Cr, 0.06-0.12 (0.08-0.11)% Mo, up to 0.30% each of copper and nickel, 0.01-0.04% titanium, 0.005-0.04% aluminium, 0.006-0.013% nitrogen, 0.0005-0.004% boron, up to 0.025 % phosphorous, 0.02-0.1% sulphur, up to 0.1% lead and up to 0.07% tellurium, optionally 0.002-0.002% calcium and the remainder iron and incidental impurities. The sum of Ni, Mo and Cu falls in the range 0.2-0.07%, and there is at least 0.005% of non-combined B at above 950 degrees C. Also claimed are a forging method and a forged piece of the steel exhibiting certain mechanical characteristics.
Patent PL-186443-B1 (PL)
Title: Method of continuously purifing crude caprolaktam obtained from 6-aminocapronitrile
Inventor: RITZ JOSEF
IPC: C07D201/16
Filed: 1995-12-22
Abstract: Cleaning raw caprolactam by hydration, subsequent treatment in an acid medium and final distillation in an alkaline medium, in which (a) 6-amino capronitrile is converted into raw caprolactam by reaction with water; (b) difficultly and easily boiling components are removed from the raw caprolactam from step (a); (c) the raw caprolactam from step (b) is treated with hydrogen at a temperature in the 50 to 150  DEG C range and a pressure in the 1.5 to 250 bar range in the presence of a hydration catalyst and, if desired, a solvent, to give a mixture A;(d1) mixture A is taken at a temperature in the 30 to 80  DEG C range and a pressure in the 1 to 5 bar range over an ion exchanger containing acid terminal groups to give a mixture B1 or (d2) mixture A is distilled in the presence of sulphuric acid, in which any solvent is removed before the addition of the sulphuric acid to give a mixture B2; and (e) mixture B1 or B2 is distilled in the presence of a base to yield pure caprolactam.
Patent PL-185592-B1 (PL)
Title: Derivatives of hydroxylamine and pharmaceutic agents against ischaemia
Inventor: UROGDI LASZLO
IPC: C07C275/64
Filed: 1996-06-14
Abstract: PCT No. PCT/HU96/00033 Sec. 371 Date May 13, 1998 Sec. 102(e) Date May 13, 1998 PCT Filed Jun. 14, 1996 PCT Pub. No. WO97/00251 PCT Pub. Date Jan. 3, 1997The present invention provides novel hydroxylamine derivatives represented by the general formula: wherein: X is O, -NH, or a group of formula NR', wherein R and R' are independently selected from alkyl, cycloalkyl, phenylalkyl, phenyl optionally substituted with halo, haloalkyl, alkyl, alkoxy or nitro; and a N-containing heterocyclic ring; R1 is H or alkanoyl, R2 is H or hydroxy optionally acylated with alkanoyl, and R3 is a group of the formula -NR4R5 wherein R4 and R5 are independently selected from H, alkyl, and a group of the formula -CO-NH-R wherein R is as defined above, or wherein R4 and R5 when taken together form a 5- to 7-membered heterocyclic ring which may optionally contain one additional hetero atom selected from nitrogen, oxygen and sulfur and which is optionally substituted with alkyl or phenylalkyl. Also provided are pharmaceutically acceptable acid addition salts of the compounds defined above, as well as pharmaceutical compositions containing the compounds or their acid addition salts as active ingredients. The compounds of the invention have been shown to have anti-ischemic effects.