baber/WOPTO huggingface dataset:
Patent FI-921925-A0 (FI)
Inventor: BRONSTEIN IRENA
IPC: C07D321/00
Filed: 1992-04-29
Abstract: Enzymatically cleavable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically cleavable labile substituent thereof is intentionally cleaved, are disclosed. These compounds can be represented by formula (I) wherein X and X<1> each represent, individually, hydrogen, a hydroxyl group, a halo substituent, an unsubstituted lower alkyl group, a hydroxy (lower) alkyl group, a halo (lower) alkyl group, a phenyl group, a halophenyl group, an alkoxyphenyl group, a hydroxyalkoxy group, a cyano group, a carboxyl or substituted carboxyl group or an amide group, with at least one of X and X<1> being other than hydrogen; and R1 and R2 individually or together, represent an organic substituent that does not interfere with the production of light when the dioxetane compound is enzymatically cleaved and that satisfies the valence of the dioxetane compound's 4-carbon atom, with the provisos that if R1 and R2 represent individual substituents the R2 substituent is aromatic, heteroaromatic, or an unsaturated substituent in conjugation with an aromatic ring, and that at least one of R1 and R2 is, or R1 and R2 taken together are, an enzymatically cleavable labile group-substituted fluorescent chromophore group that produces a luminescent substance when the enzymatically cleavable labile substituent thereof is removed by an enzyme. The corresponding dioxetanes which, instead of being substituted at the 5' or 7', or at the 5' and 7' positions, instead contain a 4' methylene group, are also disclosed, as are intermediates for all these 3-substituted adamant-2'-ylidenedioxetanes, and their use as reporter molecules in assays.
Patent FI-931073-A0 (FI)
Inventor: MOELLER JENSEN LEIF
IPC: C03B37/10
Filed: 1993-03-10
Abstract: A method and a furnace for preparing a melt for mineral fibre production, the method comprising introducing a starting material in the form of solid minerals at the upper end of a shaft which shaft at its lower end has at least one extension in the lateral direction to form a column of material forming an inclined surface in the extended part of the shaft furnace, and heating the starting material to melting by one or more burners from which a hot gas stream is emitted towards the inclined surface, and discharging melt from the bottom of the shaft furnace, and introducing mineral fibre waste material onto the inclined surface of the column of material.
Patent FI-933641-A0 (FI)
Inventor: HOWARD JR HARRY R
IPC: A61K31/4427
Filed: 1993-08-18
Abstract: The present invention relates to novel substituted benzylamino nitrogen containing nonaromatic heterocycles and, specifically, to compounds of formula (I) wherein W, R<1>, R<2>, R<3> and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula (I) are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders. <CHEM>
Patent FI-940377-A0 (FI)
Inventor: ESCHMANN SYLVESTER
IPC: D21F1/00
Filed: 1994-01-26
Abstract: A dryer screen has a paper side and a machine side. A plurality of machine direction threads extend in the direction of movement of the screen. The machine direction threads are arrayed in first and second groups. The threads of the groups are bound to the screen through different binding pattern repeats. A plurality of cross threads extend generally transverse to the machine direction threads. The threads of the first group are arrayed in first and second subgroups offset with respect to the direction of movement of the screen. Each subgroup comprises at least two abutting contiguous machine direction threads having a binding pattern repeat floating on the paper side over a predetermined plurality of cross threads.
Patent FI-951314-A0 (FI)
Inventor: SCHOTTENBERGER HERWIG
IPC: C07F17/00
Filed: 1995-03-21
Abstract: Metallocenes of formula (I) are new: M = Ti, Zr, Hf, V, Nb, Ta or a lanthanide; X1, X2 = 1-10C alkyl or alkoxy, 6-10C aryl or aryloxy, 2-10C alkenyl, 7-20C arallyl or alkaryl, 8-20C aralkenyl, H or halo; L1, L2 = (a) opt. mono- or poly-substd. mono- or poly-nuclear hydrocarbon residue with at least one cyclopentadienyl (Cp) unit, which can form a sandwich structure with M, where L1 and/or L2 is substd. and/or condensed with one or more ferrocene (Fc) or ruthenocene (Rc) gps. which are opt. substd. with X1/X2 or a Fc or Rc gp.; or (b) L1 = opt. mono- or poly-substd. Cp-contg. residue, opt. substd. and/or condensed with opt. substd. Fc or Rc as in (a), and L2 = amido, phosphido or arsenide gp. of formula E-D less than (with D = N, P or As; E = as for X+1, X2) R1 = C, Si, Ge or Sn, or the whole gp. A(R1)nB = biphenylene gp., opt. substd. with A and/or B; A, B = as for X1 and X2; n = 0.4; if n = 0, the free valencies on L1 and L2 substd. with X1 or X2, with the condition that n is not zero if L2 = amido, phosphido or arsenide gp. Also claimed the prodn. of (I) by reacting a cpd. of formula (II) with a cpd. of formula (III) (see above; with M' = alkali metal; X' = halo). Also claimed is the prodn. of polyolefins by polymerisation of olefins using (I) as catalysts, pref. with aluminoxanes as cocatalysts.
Patent FI-971333-A0 (FI)
Inventor: KNAUS DENNIS A
IPC: B29C48/05
Filed: 1997-04-01
Abstract: A continuous process for making moldable foam beads comprising a non-crosslinked or crosslinked thermoplastic polymer foam are produced by mixing a composition comprising a non-crosslinkable or crosslinkable thermoplastic polymer or a thermoplastic polymer with a crosslinking agent, additives to achieve specific properties, a blowing agent, extruding the admixture under pressure, crosslinking, when applicable, the admixture under pressure, modulating the admixtures temperature to achieve the desired foaming properties, and then expanding the admixture in a zone of lower pressure to form a foam bead that can be molded.
Patent IL-73875-A0 (IL)
Title: 1,3,4,5-tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions containing them
IPC: A61P1/00
Filed: 1984-12-20
Abstract: 1. Tetrahydrobenzindoles of the general formula  see diagramm : EP0148440,P9,F1  in which R1  and R2 denote hydrogen or C1 -C6 -alkyl or, together with the nitrogen atom, form a heterocyclic 5-membered or 6-membered ring which is optionally substituted by 1 or 2 C1 -C6 -alkyl groups, and X represents OR3  or SR3 , wherein R3  denotes hydrogen or C1 -C4 -alkyl, and salts thereof.
Patent IL-84726-A0 (IL)
Title: Pyridinesulfonylureas and their use as herbicides
Inventor: LIANG PAUL HSIAO-TSENG
IPC: C07D491/048
Filed: 1987-12-07
Abstract: Pyridinesulfonylureas of general formula: <CHEM>  wherein J is a substituted pyridyl group;  W is O or S;  R is H or CH3; A is a mono- or bicyclic heterocyclic group, e.g. pyrimidinyl or triazinyl; and their agriculturally suitable salts show high activity as preemergence and postemergence herbicides. some also show a plant growth regulant effect. The novel compounds may be made e.g. by reacting an appropriate pyridine sulfonamide JSO2NH2 with an appropriate heterocyclic phenyl carbamate:- <CHEM> t
Patent AU-PQ641100-A0 (AU)
Title: Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents
IPC: A61K51/02
Filed: 2000-03-23
Abstract: There is provided a method of synthesis of a radiolabelled platinum chemotherapeutic agent comprising the steps of: converting a metal halide to a radiolabelled platinum halide wherein the radiolabel is a radioisotope of Pt; and synthesizing the radiolabelled platinum chemotherapeutic agent from the radiolabelled platinum halide.
Patent FI-20055328-A0 (FI)
Inventor: NIEMINEN ERKKA
IPC: D21C/
Filed: 2005-06-17
Abstract: An injector of a flotation cell, the injector comprising a feed pipe for feeding a fiber suspension flow into the flotation cell, a mixing apparatus for mixing air into the fiber suspension flow and at least one air feed connection arranged before the mixing apparatus for feeding air into the injector. The injector further comprises a nozzle section which is arranged before the mixing apparatus and comprises an aperture plate provided with apertures and nozzles fixed to the aperture plate substantially at the apertures after the aperture plate, there being open spaces between the nozzles. The air to be fed from the air feed connection is arranged to flow into the spaces between the nozzles and further into the mixing apparatus with the partial flows of the fiber suspension flow entering from the nozzles.
Patent IL-100261-A0 (IL)
Title: Enzymatic preparation of grf(1-44)-nh2
IPC: A61P5/00
Filed: 1991-12-06
Abstract: GRF(1-44)-NH2 is prepared by the trypsin catalyzed enzymatic coupling of Leu-NH2 to GRF(1-43)-OH. The latter compound may be obtained by recombinant DNA synthesis. Thus the present method provides an economical way to obtain the clinically important GRF(1-44)-NH2.
Patent IL-102541-A0 (IL)
Title: Pharmaceutical antihypertensive combination preparations
IPC: A61K31/4184
Filed: 1992-07-17
Abstract: An antihypertensive combination product contains a mixture of a tetrahydronaphthalene derivative of the general formula <IMAGE> in which R<1> is halogen, R<2> is lower alkoxy-lower-alkylcarbonyloxy, X is C2-C8-alkylene and A is benzimidazolyl which is optionally substituted on the N atom by alkyl with 1 to 12 C atoms,  and of a pyridazodiazepine of the general formula <IMAGE> in which R<4> is aralkyl with 1 to 6 C atoms in the alkyl radical and phenyl in the aryl radical, where the phenyl radical is optionally monosubstituted by halogen, alkoxy with 1 to 6 atoms or phenyl, R<5> and R<6> are each, independently of one another, hydrogen or alkyl with 1 to 6 C atoms and R<7> and R<8> are hydrogen or together are an oxo group, in the form of their free bases, their hydrates or their pharmaceutically utilisable salts for concurrent, separate or sequential use.
Patent IL-104773-A0 (IL)
Title: Naphthalene derivatives,their preparation and pharmaceutical compositions containing them
IPC: A61K31/4418
Filed: 1993-02-18
Abstract: Naphthalene derivative of the formula [I]: <CHEM> wherein R<1> and R<2> are the same or different and are hydrogen atom, hydroxy group, cyclo-lower alkyloxy group, substituted or unsubstituted lower alkoxy group, or both combine each other to form lower alkylenedioxy group, R<3> is substituted or unsubstituted nitrogen-containing 6-membered heterocyclic group, and groups of the formulae: -OR<4> and -OR<5> are the same or different and are protected or unprotected hydroxy group, processes for preparing thereof, and synthetic intermediates therefor, these compounds have excellent bronchodilating activity, and are useful in the prophylaxis and treatment of asthma.
Patent IL-119297-A0 (IL)
Title: 2, 3-Dihydroxy propyl 2-(1-oxoalkyl) amino-2-deoxgylucopyranosides a process for their preparation and their uses
IPC: C11D1/66
Filed: 1996-09-25
Abstract: 2,3-dihydroxy propyl 2-amino(1-oxo alkyl) 2-desoxy-glucopyranosides of formula (I) are new. R = 5-21(pref. 7-17)C alkyl.
Patent IL-123521-A0 (IL)
Title: Wall panels and joint structures
IPC: E04C2/26
Filed: 1996-09-04
Abstract: A wall panel and joint structure for erecting structurally sound, thermally efficient and inexpensive structures for human habitat. Each wall panel includes a foam core faced on each side with reinforced cementitious facing panels, the foam edges of the composite panel being grooved peripherally inside the cementitious facing panels. At least one metal tongue member is inserted in opposing side edge grooves of abutting wall panels, and fasteners are mounted through the cementitious facing panels, any intervening foam, and into the tongue members to hold adjacent wall panels together. U-shaped channels are provided to finish an upper edge of the wall panel and to secure a bottom edge thereof to a floor structure. Wall mount clips are provided to secure the wall panels to existing subwall structures. Flanges are provided at an upper end of the tongue members to secure roofing members to the wall panels.
Patent IL-130596-A0 (IL)
Title: Method and devices for producing hydrogen by plasma reformer
IPC: C01B3/00
Filed: 1997-12-23
Abstract: One of these devices comprises: a reaction with cold plasma (10b), for producing the reforming of a primary mixture consisting of fuel gas (hydrocarbon or alcohol), as well as oxygen and/or water vapor, thus producing a secondary mixture containing in particular hydrogen, carbon dioxide and carbon monoxide; an intake piece (18) for mixing these constituents, co-operating with a burner (42) and an associated combustion chamber (40) to bring the resulting primary mixture to a high temperature, before it is introduced into the reaction chamber (10a); a ring-shaped chimney (48) enclosing this chamber for maintaining it at a relatively high temperature; a high frequency alternating high voltage source (58), modulated by brief periodical low frequency pulses and electrodes (62-66) for generating silent discharges, in the reaction chamber (10b) thus generating a cold plasma producing a high chemical reactivity to the gas mixture present; a membrane (12) with high selective permeability for extracting the nascent hydrogen, arranged between the chamber (10b) and a chamber for collecting the hydrogen (14); a thermal insulating sheath (50) enclosing the whole set. The invention is applicable to PEM type fuel cells, fitted on electric vehicles or on portable generator set.
Patent IL-133834-A0 (IL)
Title: Persephin and related growth factors
IPC: A61K48/00
Filed: 1998-09-15
Abstract: A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The human, mouse and rat amino acid sequences have been identified. Human, mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.
Patent IL-146647-A0 (IL)
Title: Method and system for distributing documents
IPC: H04L12/24
Filed: 2000-05-24
Abstract: A system for capturing an electronic message is disclosed. The system includes a printer, a sensing device and a computer system. The printer prints on a substrate user information visible to a user and coded tags invisible to the user. Each coded tag encodes an identity unique to the substrate and a location of the coded tag on the substrate. The user information defines a message area on the substrate. The sensing device senses the coded tags on the substrate when the sensing device is moved relative to the substrate. The computer system electronically captures a message composed with the sensing device via movement of the sensing device relative to the message area, the computer system using the identity of the substrate and a sequence of respective locations of coded tags sensed by the sensing device for determining the movement relative to the message area and the message.
Patent IL-147840-A0 (IL)
Title: Device for automatically injecting liquids
IPC: A61M5/315
Filed: 2000-07-27
Abstract: The invention concerns a device for automatically injecting injection liquids, comprising an axially divided housing, whereof the parts can be removably assembled. In a first part of the housing (13) is guided an axially mobile pressure pin (14) which can be driven in against a force accumulator (15), which can be locked once it has been driven in and can come out when the force accumulator (15) is released. In a second part of the housing (1) are arranged, axially mobile, an injection needle (4) maintained in a needle guide (5) and an ampoule (3). Said injection needle (4) maintained in the needle guide (5) can be axially mobile, relative to the ampoule (3), and has, on its side facing the ampoule (3), a perforation part (23) designed to perforate the ampoule (3). The second part of the housing (1) can be closed with a top (11) at its open end facing the first part of the housing (13).
Patent IL-148615-A0 (IL)
Title: Genetic markers of toxicity, preparation and uses thereof
IPC: C12Q1/6837
Filed: 2000-09-12
Abstract: The present invention describes new methods for the determination of the potential toxicity of test compounds, as well as the kits and tools for the implementation of these methods. The invention also describes methods for generating nucleic acid sequences that can be used as genetic markers of toxicity. The invention is based in particular on the creation of differential nucleic acid banks characteristic of situations in which cell viability and/or proliferation are deregulated, and on the demonstration that these banks can be used to evaluate the toxicity profile of compounds with reliability and high sensitivity. The invention is of special utility in the pharmaceutical industry for analysis of the toxicity profile of compounds involved in drug development and/or in pharmaceutical compositions.
Patent IL-154646-A0 (IL)
Title: Intravaginal device for electrically stimulating and/or for sensing electrical activity of muscles and/or nerves defining and surrounding the intravaginal cavity
IPC: A61B5/04
Filed: 2001-08-30
Abstract: A device for stimulating muscles and nerves defining and surrounding an intravaginal cavity of an individual and/or for sensing tonus and/or electrical activity of muscles defining and surrounding an intravaginal cavity is provided. The device includes (a) a body having memory properties such that when the body is contracted and positioned within an intravaginal cavity of the individual the body self expands to conform to a contour of the intravaginal cavity; and (b) at least one pair of electrodes being attached to an exterior surface of the body such that when the body is positioned within the intravaginal cavity, each electrode of the at least one pair of electrodes is biased against a wall of the intravaginal cavity. Thus they maintain electrical contact with the wall.
Patent IL-159971-A0 (IL)
Title: Electric shaver
Inventor: SHALEV PINCHAS
IPC: A45D26/00
Filed: 2002-07-21
Abstract: A hair cutting apparatus comprising a structure (1260), a portion (1216) of which being adapted for placement against a skin surface where hair is to be cut, a heat generator comprising one or more heat elements (1214) heated to a temperature sufficient to cut hair, at least one of said heat elements being juxtaposed with said portion and positioned to touch said skin and a controller that controls said heat generator to prevent heat from being applied continuously in a single area for sufficient time to cause skin damage.
Patent IL-165711-A0 (IL)
Title: Heat transfer tube and method of and tool for manufacturing the same
IPC: F28F1/42
Filed: 2004-12-12
Abstract: A method of manufacturing a heat transfer tube comprises cutting through at least one ridge (1) formed along the surface of the tube at an angle relative to the tube longitudinal axis (s). The ridge is cut to a cutting depth (t) to form ridge layers (4) and the ridge layers are lifted to form a plurality of protrusions projecting from the surface in a direction that is not perpendicular to the tube longitudinal axis. Some or all of the protrusions may have an at least partially twisted configuration.
Patent IL-173027-A0 (IL)
Title: Composition for protecting or treating plants and fruit from fungal and bacterial infections
IPC: A01N63/50
Filed: 2006-01-09
Abstract: The present invention relates to a novel antibiotic-producing and metabolite-producing Bacillus subtilis strain that exhibits insecticidal, antifungal and antibacterial activity. The supernatant of this novel strain contains effective insecticidal, antifungal and antibacterial agents. Also included in the invention is a solvent extractable, small molecular weight (<10,000 daltons) corn rootworm-active metabolite produced in the supernatant. Also included in the invention are methods of protecting or treating plants from fungal and bacterial infections and corn rootworm infestations comprising the step of applying to the plant an effective amount of the antibiotic/metabolite-producing novel Bacillus subtilis strain, the antibiotic/metabolite produced by the novel Bacillus subtilis strain or a combination thereof, optionally further comprising another antibiotic-producing bacterial strain and/or a chemical pesticide. The invention also includes methods of preventing or treating fungal and bacterial infections using whole broth cultures or supernatants obtained from cultures of the novel Bacillus subtilis strain alone or in combination with chemical pesticides and/or other biocontrol agents. The invention also includes novel antifungal and antibacterial compounds designated agrastatins and a novel combination comprising an A-type iturin, a plipastatin, a surfactin and an agrastatin. Methods of treating or protecting plants from fungal and bacterial infections and corn rootworm infestations comprising administering the novel agrastatins and the novel combination comprising an A-type iturin, a plipastatin, a surfactin and an agrastatin are provided.
Patent IL-177854-A0 (IL)
Title: 9-substituted minocycline compounds
IPC: C07C275/42
Filed: 2006-09-03
Abstract: The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
Patent IL-183054-A0 (IL)
Title: Lna oligonucleotides and pharmaceutical compositions containing the same
IPC: C12N15/113
Filed: 2007-05-08
Abstract: The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5′-(Tx)GxGxcsasasgscsastscscsTxGxT-3′ and 5′-(Gx)TxTxascstsgscscststscsTxTxA-3′, wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide, subscript s designates a phosphorothioate link between neighboring nucleotides/LNA nucleotide analogues, and subscript x designates either a phosphorothioate link or a phosphorodiester link between neighboring nucleotides/LNA nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g. diabetic retinopathy, macular degeneration (ARMD), psoriasis, rheumatoid arthritis and other inflammatory diseases.
Patent IL-189136-A0 (IL)
Title: Glucagon-like insulinotropic peptide analogs, compositions comprising them and uses thereof
IPC: A61P5/50
Filed: 2008-01-30
Abstract: Derivatives of GLP-1 and analogues thereof having a lipophilic substituent have interesting pharmacological properties, in particular they have a more protracted profile of action than GLP-1(7-37).
Patent IL-191173-A0 (IL)
Title: Powder dispensing and sensing apparatus and methods
IPC: B67D7/30
Filed: 2008-04-30
Abstract: A powder dispensing and sensing apparatus having the capability to fill inhaler cartridges and characterized by an array of weight sensor assemblies (110); and a sensor housing (100) mounting the weight sensor assemblies of the array in fixed relative positions to sense weights of cartridges (20) in a matching array (22) of said cartridges.