baber/WOPTO huggingface dataset:
Patent NZ-245819-A (NZ)
Title: Phosphonooxy and carbonate derivatives of taxol, preparation and pharmaceutical compositions thereof
Inventor: UEDA YASUTSUGU
IPC: C07F9/6558
Filed: 1993-02-01
Abstract: A taxol derivative of formula I <CHEM>  or a pharmaceutically acceptable salt thereof, in which   R<j> is   -COR<z> in which R<z> is t-butyloxy, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, or phenyl, optionally substituted with one to three same or different C1-6 alkyl, C1-6 alkoxy, halogen or -CF3 groups; R<y> is   C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, or a radical of the formula -W-R<x> in which W is a bond, C2-6 alkenediyl, or -(CH2)t-, in which t is one to six; and R<x> is naphthyl, furyl, thienyl or phenyl, and furthermore R<x> can be optionally substituted with one to three same or different C1-6 alkyl, C1-6 alkoxy, halogen or -CF3 groups; R<w> is   hydrogen, hydroxy, acetyloxy, -OC(=O)OY or -OZ; R<1> is   hydrogen, hydroxy, -OC(=O)OY or -OZ; R<2> is hydroxy, -OC(=O)OY, -OC(=O)R or -OZ, with the proviso at least one of R<1>, R<2> or R<w> is -OC(=O)OY or -OZ; R is   C1-6 alkyl; Z is   of the formula <CHEM>  or   <CHEM>  wherein   R<3> and R<4>   are independently hydrogen or C1-6 alkyl, or R<3> and R<4> taken together with the carbon atom to which they are attached form C3-6 cycloalkylidene; R<5> is   -OC(=O)R, -OP=O(OH)2 or -CH2OP=O(OH)2; R<6>, R<7>, R<8> and R<9>   are independently halogen, C1-6 alkyl, C1-6 alkoxy or hydrogen; or one of R<6>, R<7>, R<8> and R<9> is -OC(=O)R, -OP=O(OH)2 or hydroxy, and the others are independently halogen, C1-6 alkyl, C1-6 alkoxy or hydrogen; but when R<5> is -OC(=O)R, one of R<6>, R<7>, R<8> or R<9> must be -OP=O(OH)2; Q is   -(CH2)q-, optionally substituted with one to six same or different C1-6 alkyl or C3-6 cycloalkyl, or a carbon atom of said -(CH2)q- group can also be a part of C3-6 cycloalkylidene; q is   2 to 6; n is 0, and m is 1 or 0 when R<5> is -CH2OP=O(OH)2; n is 1 or 0, and m is 1 when R<5> is -OC(=O)R or -OP=O(OH)2; Y is   C1-6 alkyl (optionally substituted with -OP=O(OH)2 or one to six same or different halogen atoms), C3-6 cycloalkyl, C2-6 alkenyl, or a radical of the formula   <CHEM>  in which D is a bond or -(CH2)t-, optionally substituted with one to six same or different C1-6 alkyl; and R<a>, R<b> and R<c> are independently hydrogen, amino, C1-6alkylamino, di-C1-6alkylamino, halogen, C1-6 alkyl, or C1-6 alkoxy; and with the further proviso that R<2> cannot be -OP=O(OH)2; and Y cannot be -CH2CCl3.
Patent NZ-248343-A (NZ)
Title: Quinolin-2-yl-methoxyphenylacetic acid derivatives and medicaments
Inventor: MATZKE MICHAEL
IPC: C07D215/14
Filed: 1993-08-06
Abstract: 2-Substituted quinolylmethoxyphenylacetic acid derivatives of the general formula (I) <IMAGE>  in which     A, B, D, E, G and L are identical or different and stand for hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy or for straight-chain or branched alkyl or alkoxy in each case having up to 8 carbon atoms, or for aryl having 6 to 10 carbon atoms, which is optionally substituted by halogen, hydroxyl, nitro or cyano, R<1> stands for halogen, cyano, nitro, azido, hydroxyl, carboxyl, trifluoromethyl, trifluoromethoxy or trifluoromethylthio, or for straight-chain or branched alkenyl or alkynyl in each case having up to 8 carbon atoms, each of which is optionally substituted by phenyl or cycloalkyl having 3 to 8 carbon atoms, or for cycloalkyl having 3 to 8 carbon atoms or phenyl, or for straight-chain or branched alkoxy or alkoxycarbonyl in each case having up to 6 carbon atoms, R<2> stands for hydrogen or for straight-chain or branched alkyl having up to 6 carbon atoms, or  for cycloalkyl having 3 to 12 carbon atoms, R<3> stands for hydroxyl, for straight-chain or branched alkoxy having up to 8 carbon atoms or phenyl, or  for a group of the formula -NR<4>SO2R<5> or -NR<6>R<7>,  in which R<4>, R<6> and R<7> are identical or different and denote hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms, phenyl or benzyl, R<5> denotes trifluoromethyl or phenyl which is optionally substituted by halogen, cyano, hydroxyl, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio or by straight-chain or branched alkyl or alkoxy in each case having up to 6 carbon atoms, or denotes straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by phenyl which, for its part, can be substitued by halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, hydroxyl or by straight-chain or branched alkyl or alkoxy in each case having up to 6 carbon atoms  and their salts. 2-Substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of appropriately substituted phenols with quinolylmethyl halides or by reaction of unsubstituted phenols with quinolylmethyl halides and subsequent alkylation. The 2-substituted quinolylmethoxyphenylacetic acid derivatives can be employed as active compounds in medicaments. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.
Patent NZ-269019-A (NZ)
Title: Method of inducing transduction with retroviral assistance
Inventor: FINER MITCHELL H
IPC: C12N15/87
Filed: 1994-06-10
Abstract: he disclosure provides a retroviral packaging system, in which retroviral packaging constructs, and packaging vector transcripts are produced from high expression plasmids by transfection in human cells. High titers of recombinant retroviruses are produced in infected cells. The methods include the use of the retroviral constructs to transduce primary human cells, including T cells and human hematopoietic stem cells, with foreign genes by cocultivation at high efficiencies. Said method is useful for the rapid production of high titer viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.
Patent NZ-503701-A (NZ)
Title: In-line electric water heater, with PTC element, controller monitors first and second derivatives of resistance vs time
Inventor: THWEATT CARLISLE
IPC: F24H9/20
Filed: 2000-03-31
Abstract: An in-line, continuous flow water heater includes element 22 made from a positive temperature coefficient (PTC) material.  The current passing through the element is monitored by sensor 34.  This information is used by a controller to calculate the resistance of the element.  The controller also calculates the first and second derivatives of the resistance as a function of time.  These derivatives are used to determine whether an unsafe state is developing, for example low water flow, or that there is no water present at all.  If the development of an unsafe state is detected, then the power supply to the element is cut off.
Patent NZ-505580-A (NZ)
Title: Method of treating immunodeficiences using neutrokine alpha
Inventor: YU GUO-LIANG
IPC: C12N5/10
Filed: 1996-10-25
Abstract: Use of an antibody or portion thereof that specifically binds a Neutrokine-alpha protein purified from a cell culture, for the preparation of a medicament for the treatment of rheumatoid arthritis.
Patent NZ-508086-A (NZ)
Title: Animal feed teat valve assembly having a piston shaft and piston head with biasing device
Inventor: MCKEE WILLIAM DOUGLAS
IPC: A01K7/06
Filed: 1999-05-06
Abstract: The invention described is a valve assembly adapted for use in an animal feeding teat and an animal feeding teat in combination with the above valve assembly. The valve assembly comprises: a piston shaft (10) with a piston head (12), a valve head (14) attached to the piston shaft (10) at the end of the shaft opposite the piston head (12), and biasing means (16) co-operable with said piston head (12), so that in use in an animal feeding teat said valve head (14) is seated to cover a first aperture (22) in said teat (17) and pressure on said piston head (12) against said biasing means (16) will unseat said valve head (14) and open said aperture (22). This invention is directed towards the valve and animal feeding teat assembly.
Patent NZ-509861-A (NZ)
Title: Method of performing transgenesis
Inventor: WAKAYAMA TERUHIKO
IPC: C12R1/91
Filed: 1999-08-11
Abstract: A method of causing oocyte development in mouse oocytes comprising intrcytoplasmically injecting dead sperm heads into metaphase II mouse oocytes.
Patent NZ-510891-A (NZ)
Title: Plastic pipe with three layers and barrier material in intermediate layer to prevent migration of additives from inner and/or intermediate layers
Inventor: ROSENBERG GERHARD
IPC: B29C48/09
Filed: 2001-04-02
Abstract: An extruded, injection-molded or blow-molded plastic member for pipelines used for transporting liquid, pasty, and gaseous media, the plastic member comprising: (a) A tubular body (1) comprised of an outer layer (3), an intermediate layer (4) connected radially inwardly to the outer, and an inner layer (2) connected radially inwardly to the intermediate layer, wherein the inner layer is in contact with a medium to be transported; (b) Wherein the inner layer and the outer layer are comprised of a basic material and the intermediate layer is comprised of a composite material of a basic material and an additional material, wherein the basic material of the inner layer and of the intermediate layer is a polymer material, wherein the polymers material comprises amorphous areas; (c) Addictives against aggressive media embedded in the amorphous areas of the polymer material of at least one of the inner layer and the intermediate layer; (d) Wherein the additional material is a barrier material, selected from the group comprised of fillers and additives, embedded in the amorphous areas of the polymer material of the intermediate layer and the configured to reduce migration of the additives embedded in the amorphous areas of the polymer material of the inner layer.
Patent NZ-514869-A (NZ)
Title: Apparatus and method for detecting far end speech
Inventor: KYRYLENKO MYKOLA
IPC: G10L11/00
Filed: 2000-04-28
Abstract: Method and apparatus for detecting far end speech in a telephone apparatus. A speaker (14) reproduces far end sound from a far end signal, when received by the telephone apparatus. A microphone (12) generates a near end signal from near end sound, for transmission from the telephone apparatus. A hybrid (24) which passes the near and far end signals from an external two wire link (30) to and from the speaker and microphone, on respective first and second paths (1, 2) of a four wire link (28). Muting of the near end signal is effected when signal derived from the first path (1) of the four wire link (28) is detected as being representative of a condition of existence of far end signal. Signal determined as representing sidetone signal deriving from the near end signal from the speaker (14), and appearing in the signal on the first path (1) of the four wire link (28), pursuant to traverse of part of near the end signal through the hybrid, is subtracted from the signal derived from the first path (1) of the four wire link (28). Existence of the condition of existence of far end signal is then determined on the basis of the result of the subtraction.
Patent NZ-514985-A (NZ)
Title: Key and lock each storing secret information enabling unblocking of locking device after exchange of random numbers
Inventor: LIDEN INGE
IPC: G07C9/00
Filed: 2000-05-05
Abstract: A key and lock devices comprises a key (10) having a first electronic circuitry (14) and a lock (20) having a second electronic circuitry (24). The key and the lock store secret information, some of which is unique for each device. The key and the lock exchange a random number through connectors (15, 25) and perform a calculation in the respective circuitry based on the random number and secret information. An electrical blocking mechanism (40) is moved to a non-blocking position if a comparison of the calculations in the circuits gives an expected result.
Patent NZ-520632-A (NZ)
Title: Acylated protein hydrogel in which the crosslinked protein matrix is treated witha polar organic solvent
Inventor: DAMODARAN SRINIVASAN
IPC: B01J20/26
Filed: 2001-01-26
Abstract: A protein hydrogel comprises an acylated protein matrix. The acylated protein matrix is crosslinked with a bifunctional cross linking reagent to yield a cross linked protein matrix. The cross linked protein matrix is then treated with a polar organic solvent. A protein hydrogel can also comprise a (a) fish protein isolate, the fish protein isolate being acylated by treatment with ethylenediaminetetraacetic acid dianhydride to yield an acylated protein; (b) the acylated protein being cross linked with glutaraldehyde to yield a cross linked protein matrix and (c) the crosslinked protein matrix being treated with a polar organic solvent. Also described is method of making a protein hydrogel.
Patent NZ-522234-A (NZ)
Title: Use of alpha-halogenoacryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione
Inventor: GERONI MARIA CRISTINA ROSA
IPC: A61K31/4025
Filed: 2001-04-19
Abstract: a-halogenoacryloyl distamycin derivatives of formula (I) and their pharmaceutically acceptable salts that are cytotoxic agents particularly effective in the treatment of tumors that over express GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies are disclosed, wherein R1 is a bromine or chlorine atom; R2 is a distamycin-like framework as defined in the specification.
Patent NZ-525188-A (NZ)
Title: Improvements in detection
Inventor: FERGUSON DREW MERCER
IPC: C12Q1/04
Filed: 2001-10-15
Abstract: An indicator suitable for detecting the presence of a substance or a microbe at a location which indicator comprises: (a) a layer, such as a biopolymer, which is susceptible to degradation by the substance or microbe or a first substance associated with the microbe; (b) a signaling layer which is adapted to produce a detectable signal which indicates the presence of the substance or microbe or a second substance associated with the microbe or a further substance which is located at substantially the same location as the substance or microbe; wherein, in use, the signaling layer (b) is at least initially protected from contact with the substance or microbe or the second substance associated with the microbe or the further substance which is located at substantially the same location as the substance or microbe by the layer (a); a dressing for a wound or a suture comprising the indicator; packaging for foodstuffs comprising the indicator; and a process for the production of the indicator.
Patent NZ-530302-A (NZ)
Title: Thermal barrier for air handling unit (AHU) cabinet
Inventor: ADAMS JOHN C
IPC: F24F13/20
Filed: 2002-07-11
Abstract: A panel (12) is disclosed for use in air conditioning duct for carrying air along an enclosed path of travel. The panel includes a rectangular shaped frame made of a material having a relatively high R value. The frame is closed by a top cover and a bottom cover so that a cavity is established within the panel. The cavity is filled with a curable material that sets inside the panel to bond the walls of the frame together and to bond the covers to the frame. A bulb seal (not shown) having high insulation characteristics extending along the length of one edge of adjoining panels so that energy transmission is further inhibited.
Patent NZ-532130-A (NZ)
Title: Use of irbesartan for the preparation of medicaments that are used to prevent or treat pulmonary hypertension
Inventor: COSNIER-PUCHEU SYLVIE
IPC: C07D401/10
Filed: 2002-10-09
Abstract: Disclosed is a use of irbesartan, a pharmaceutically acceptable salt thereof or a solvate thereof, in the preparation of a medicament for preventing or treating pulmonary arterial hypertension in which said pulmonary hypertension corresponds to an increase in the pulmonary arterial network to above 35 mm Hg.
Patent NZ-532990-A (NZ)
Title: Nuclear protein "Shoca" - a component of the Wnt signalling pathway
Inventor: HOLLANDER GEORG ANDREAS
IPC: A61K45/00
Filed: 2002-12-03
Abstract: Described is an isolated polypeptide that comprises: (i) an amino acid sequence of SEQ ID NO: 2 and SEQ ID NO: 4; or (ii) a variant thereof having at least 70% identity of the amino acid sequence of SEQ ID NO: 2 and SEQ ID NO: 4 which is capable of interacting with a polypeptide of the wnt signalling pathway; or (iii) a fragment of (i) or (ii) that is at least 20 amino acids in length and capable of interacting with a polypeptide of the wnt signalling pathway selected from beta-catenin, T-cell factor (TCF) and leukocyte enhancer factor (LEF). Also described are host cells, polypeptide specific antibodies, a method of identifying an agent capable of modulating the wnt signalling pathway and a method of diagnosing cancer.
Patent NZ-537779-A (NZ)
Title: Increase in the yield of secreted protein by the introduction of an amino acid sequence motif, preferably by modification of leader sequences
Inventor: SLEEP DARRELL
IPC: C12N15/62
Filed: 2003-07-23
Abstract: Described is a polypeptide comprising (i) a leader sequence, the leader sequence comprising a (a) secretion pre sequence, and (b) the following motif: -X1-X2-X3-X4-X5- where X1 is phenylalanine, tryptophan, or tyrosine, X2 is isoleucine, leucine, valine, alanine or methionine, X3 is leucine, valine, alanine or methionine, X4 is serine or threonine and X5 is isoleucine, valine, alanine or methionine; and (ii) a desired protein heterologous to the leader sequence. The polypeptide may additionally comprise, as part of the leader sequence, a secretion pro sequence.
Patent NZ-544116-A (NZ)
Title: A probiotic composition comprising at least two lactic acid bacterial strains which are able to colonise the gastrointestinal tracts in combination with having intestinal survival property, intestinal binding property, an infection protection property and a fiber fermenting property
Inventor: LJUNGH-WADSTROM ASA
IPC: A61K35/74
Filed: 2004-05-18
Abstract: Disclosed is a probiotic composition comprising at least two specific lactic acid bacterial strains, the strains are able to colonize the gastrointestinal tract of humans and animals and have in combination at least two beneficial properties. The properties include an intestinal survival property, an intestinal binding property, an infection protecting property, and a fibre fermenting property. The two lactic acid bacterial strains are selected from Lactobacillus plantarum F5 (LMG P-20604), Lactobacillus plantarum F26 (LMG P-20605), Lactobacillus plantarum F2592 (LMG P-20606), Pediococcus penosaceus 16:1 (LMG P-20608), and Leuconostoc mesentorides 77:1 (LMG P-20607), Lactobacillus plantarum 50:1 (P-20609), and Lactobacillus paracasei (paracasei) F19 (LMG P-17806).
Patent NZ-545501-A (NZ)
Title: Packaging cells for recombinant adenovirus
Inventor: VOGELS RONALD
IPC: C12N5/10
Filed: 2004-10-04
Abstract: Provided is a method of preparing a cell having adenovirus ElA and ElB-19K and ElB-55K coding sequences integrated into its genome, the method comprising the steps of introducing into a precursor cell: a single nucleic acid molecule comprising the ElA and ElB-19K and ElB-55K coding sequences, wherein said ElA and at least one of the EIB coding sequences are separated by at least 8 kb; or two or more nucleic acid molecules comprising the ElA and ElB-19K and ElB-55K coding sequences wherein said ElA and at least one of the ElB coding sequences are separated by at least 8 kb when said two or more nucleic acid molecules would form a single molecule by end-to-end joining. The cells are useful for the generation of batches of recombinant adenoviruses.
Patent NZ-552238-A (NZ)
Title: An extract
Inventor: WILLIAMS CHARLES EDWARD
IPC: A23L33/00
Filed: 2006-12-20
Abstract: Disclosed are compositions that include an oil extract rich in fatty acid amide compounds including N-acylethanolamine (NAE) compounds such as N-palmitoylethanolamide (PEA) and N-arachidonoylethanolamide (AEA). The compositions may be derived from marine materials including bivalve molluscs such as mussels. The compositions include at least 0.10 micrograms/gram of PEA as measured in the wet weight of the bivalve mollusc flesh prior to concentration.
Patent NZ-552745-A (NZ)
Title: Expression-enhanced polypeptides
Inventor: HOFFMANN PATRICK
Filed: 2005-07-15
Abstract: A composite polypeptide, said composite polypeptide comprising a desired polypeptide and an expression enhancing domain ('EED'), said EED comprising first and second cysteine amino acid residues Cys1 and Cys2, respectively, Cys1 being located closer to the N-terminus of the composite polypeptide molecule than Cys2, wherein Cys1 and Cys2 are separated by a polypeptide linker, said linker - being free of cysteine and proline; - defining a length sufficient to allow Cys1 and Cys2 to engage in an intramolecular disulfide bond with one another; and - having a flexible polypeptide conformation essentially free of secondary polypeptide structure in aqueous solution, wherein at least one of Cys1 and Cys2 is derivatized with a derivatization moiety wherein the desired polypeptide is an antibody.
Patent NZ-553153-A (NZ)
Title: Self-deployable tent comprising an internal chamber
Inventor: METTAVANT BENJAMIN
Filed: 2004-12-14
Abstract: The disclosed self-deployable tent comprises an arched structure consisting of a base loop (2), at least one top loop (3) and a roof skin (5) connected to said base (2) and top (3) loops. Said tent also comprises an internal chamber (6) which is disposed under the roof skin (5) and provided with a top part (6a) connected to the top loop (3) by flexible spreader means (8) and a bottom part (6b) connected to the base loop (2). In a unfolded position of the tent, the tension of the roof skin (5) and the internal chamber (6) is selected such that they are remote from each other by said spreader means (8).
Patent NZ-556694-A (NZ)
Title: Self-sealing male connector device wherein a slit valve opens when attached to the matching female connector
Inventor: RAYBUCK JOHN
IPC: F16L29/02
Filed: 2005-12-16
Abstract: A self-sealing male connector device (30) for connection with a female Luer connector is disclosed. The device (30) has an elongated male body (52) configured with lengthwise relatively rigid and flexible wall segments (44) cooperating to allow the body (52) to be radially compressed from an expanded configuration to a contracted configuration. A closure cap (38) formed with a resealable aperture (54) is disposed on the distal end of the male body (52) so as to be responsive to the compression of the male body (52). The relatively flexible wall segments (44) may be installed within notches (50) in the male body or be formed integral with the relatively rigid wall segments.
Patent NZ-562766-A (NZ)
Title: Piperidine derivatives as histamine-H3 receptor antagonists
Inventor: ISHIKAWA SHIHO
IPC: A61K31/438
Filed: 2006-05-29
Abstract: Disclosed is a compound of formula (I), or a salt thereof, where R1 and R2 form a spirocyclic ring attached to the piperidine, and where the spirocyclic ring and the other substituents are as defined in the specification. Also disclosed is the use of the compound to treat metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout and fatty liver; circulatory system diseases, for example, stenocardia, acute/congestive cardiac insufficiency, cardiac infarction, coronary arteriosclerosis, hypertension, nephropathy and electrolyte disorder; sleep disorder and various diseases accompanied by sleep disorder, for example, idiopathic hypersomnia, repetitive hypersomnia, true hypersomnia, narcolepsy, sleep periodic acromotion disorder, sleep apnea syndrome, circadian rhythm disorder, chronic fatigue syndrome, REM sleep disorder, senile insomnia, night workers' sleep insanitation, idiopathic insomnia, repetitive insomnia and true insomnia; central and peripheral nervous system diseases, for example, bulimia, emotional disorder, depression, anxiety, delirium, dementia, schizophrenia, attention deficit/hyperactivity disorder, memory disorder, Alzheimer's disease, Parkinson's disease, sleep disorder, cognition disorder, motion disorder, paresthesia, dysosmia, epilepsy, morphine resistance, drug dependency and alcoholism.