baber/WOPTO huggingface dataset:
Patent NZ-580116-A (NZ)
Title: Therapy of autoimmune disease in a patient with an inadequate response to a TNF-alpha inhibitor
Inventor: BENYUNES MARK C
IPC: A61K39/395
Filed: 2009-10-01
Abstract: Provided is the use of rituximab in the manufacture of a medicament for treating rheumatoid arthritis by administration of two doses of the medicament comprising 1000 mg of rituximab to a mammal who experiences an inadequate response to a TNF alpha inhibitor, wherein the first dose is for administration on day 1 of treatment and the second dose on day 15. Rituximab may be combined with methotrexate or a corticosteroid. (62) Divided Out of 568415
Patent NZ-585340-A (NZ)
Title: Coated tablet composition comprising a coat for immediate release glucocorticoid and a core for extended release glucocorticoid for glucocorticoid replacement therapy
Inventor: SKRTIC STANKO
IPC: A61K9/20
Filed: 2005-04-21
Abstract: Discloses a coated tablet composition for administration once daily comprising a coating and a tablet core. The coating comprises an immediate release part comprising one or more glucocorticoids and pharmaceutically acceptable release excipients or carriers adapted so that the one or more glucocorticoids are immediately released. The coating contains an amount of 20-40 % of the total hydrocortisone equivalents in the composition. The tablet core comprises an extended release part comprising one or more glucocorticoids in an amount of 60-80% of the total hydrocortisone equivalents in the composition and pharmaceutically acceptable extended release excipients or carriers adapted so that the one or more glucocorticoids are released over an extended period of time of at least about 8 hours. The total daily dose of the glucocorticoids is in the range 1-80 mg. Further disclosed are various embodiments of the composition that detail the amount of total hydrocortisone equivalents released in a given timeframe from either the immediate release part or the extended release part of the composition. Also disclosed is the use the coated tablet composition used in the preparation of a medicament for the treatment of a glucocorticoid deficiency associated disorder.
Patent NZ-590170-A (NZ)
Title: Process for the preparation of substituted pyrimidine derivatives
Inventor: CESCO-CANCIAN SERGIO
IPC: A61K31/497
Filed: 2009-06-29
Abstract: Disclosed herein is a process for the preparation of a compound of formula (I), in particular a compound of formula (I-S), wherein the substituents are as defined within the specification, wherein the process comprises reacting a compound of formula (V) with a compound of formula (VI) in a first organic solvent and in the presence of a coupling agent system to yield the corresponding compound of formula (VII), de-protecting the compound of formula (VII), to yield the corresponding compound of formula (VIII); and followed by reacting the compound of formula (VIII) with a compound of formula (IX) in a second organic solvent to yield the corresponding compound of formula (I).
Patent NZ-591973-A (NZ)
Title: Anti-viral compounds to treat hcv infection
Inventor: DEGOEY DAVID A
IPC: A61K31/4439
Filed: 2010-06-10
Abstract: 591973 Disclosed are pyrolidine compounds of formula (I) where X is pyrolidine, effective in inhibiting replication of Hepatitis C virus ( HCV ) are described. This disclosure also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. Examples of compounds are: dimethyl (2S,2'S)-1, 1'-((2S,2'S)-2,2'-( 4,4'-((2S,5S)-1-(4-fluorophenyl)pyrrolidine-2,5-diyl)bis( 4,1-phenylene))bis(azanediyl)bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane- 2,1-diyl)dicarbamate; dimethyl (2S,2'S)-1, 1'-((2S,2'S)-2,2'-(4,4'-((2S,5S)-1-(4-tert-butylphenyl)pyrrolidine-2,5-diyl)bis( 4,1-phenylene))bis(azanediyl)bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate; and dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(4,4'-((2R,5R)-1-(4-tert-butylphenyl)pyrrolidine-2,5-diyl)bis( 4,1-phenylene))bis(azanediyl)bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane- 2,1-diyl)dicarbamate.
Patent NZ-592484-A (NZ)
Title: Cleaning method
Inventor: BELL DUNCAN
IPC: B08B3/08
Filed: 2009-10-23
Abstract: Disclosed is an in place cleaning method, the method comprising the steps of (a) treating the foulant with an acidic solution to remove metal ions from the foulant; and (b) basifying the acidic solution thereby contacting the treated foulant with a basic solution to remove at least some of the treated foulant wherein the acidic solution and/or the basic solution comprise at least one chelant in an amount sufficient to stabilise metal ions in the basic solution.
Patent NZ-598601-A (NZ)
Title: Dosage regimen for administering an epcamxcd3 bispecific antibody
Inventor: ZUGMEIER GERHARD
IPC: A61K39/395
Filed: 2010-09-20
Abstract: Disclosed is the use of an EpCAMxCD3 bispecific single-chain antibody for the preparation of a pharmaceutical composition for ameliorating and/or preventing a medical condition, mediated by the continued (therapeutic) administration of an EpCAMxCD3 bispecific antibody to a human patient, wherein: (a) a first dose of said antibody is formulated for continuous administration for a first period of time; and (b) a second dose of said antibody is formulated for continuous administration for a second consecutive period of time; wherein said second dose exceeds said first dose, and wherein said medical condition is characterised by an increase of the serum level of at least one liver enzyme. Also disclosed is a pharmaceutical package or kit comprising a first dose of an EpCAMxCD3 bispecific single-chain antibody formulated for continuous administration for a first period of time, and a second dose of an EpCAMxCD3 bispecific single-chain antibody formulated for continuous administration for a second consecutive period of time, wherein said second dose exceeds said first dose, and wherein said antibody comprises the six CDR sequences of MT110.
Patent NZ-604915-A (NZ)
Title: Recombinant production of steviol glycosides
Inventor: KISHORE GANESH M
IPC: A23L27/30
Filed: 2011-06-02
Abstract: Disclosed is a non-human recombinant host comprising: (a) a gene encoding a UGT91D2 polypeptide having at least 90% sequence identity to the amino acid sequence set forth in SEQ ID NO:5; and one or more of (b) a gene encoding a UGT85C polypeptide, comprising a UGT85C polypeptide having at least 90% sequence identity to the amino acid sequence set forth in SEQ ID NO:3; and/or (c) a gene encoding a UGT76G1 polypeptide, comprising a UGT76G1 polypeptide having at least 90% sequence identity to the amino acid sequence set forth in SEQ ID NO:7; and/or (d) a gene encoding a UGT74G1 polypeptide, comprising a UGT74G1 polypeptide having at least 90% sequence identity to the amino acid sequence set forth in SEQ ID NO:1; wherein at least one of said genes is a recombinant gene; and, wherein the recombinant host produces a steviol or steviol glycoside. The sequences are as disclosed in the specification.
Patent NZ-609952-A (NZ)
Title: Adjuvant fragments from leishmania species
Inventor: ALONSO-BEDATE CARLOS
IPC: G01N33/569
Filed: 2011-11-10
Abstract: Disclosed is a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of: i. nucleotide sequences encoding a polypeptide comprising an amino acid sequence that has at least 50 % sequence identity with the amino acid sequence of SEQ ID NO:1 over its entire length, ii. nucleotide sequences comprising a nucleotide sequence that has at least 50 % sequence identity with the nucleotide sequence of SEQ ID NO:2 over its entire length, iii. nucleotide sequences the complementary strand of which hybridises to a nucleic acid molecule of sequence of (i) or (ii) and iv. nucleotide sequences which differ from the sequence of a nucleic acid molecule of (iii) due to the degeneracy of the genetic code, operably linked to a nucleotide sequence encoding an antigen, wherein the nucleic acid molecule encodes a polypeptide which is able to elicit an antigen-specific immune response in a subject, wherein the nucleic acid molecule is free of a sequence encoding for a polypeptide which is identical to SEQ ID NO: 3 over its entire length; wherein the sequences are as disclosed in the specification.
Patent NZ-610765-A (NZ)
Title: Method for the preparation of high-purity pharmaceutical intermediates
Inventor: KOVÁNYINÉ LAX GYÖRGYI
IPC: C07D239/42
Filed: 2011-11-29
Abstract: The disclosure relates to a method for the preparation of rosuvastatin tert-tertbutylammonium (TBA) salt of the formula (III) which is an intermediate useful in the manufacture of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid, wherein the method comprises reacting a rosuvastatin ester of the formula (II) having solid crystalline form where in the formula (II) R represents methyl, ethyl or tert-butyl using a polar solvent, with 1.5 to 5 molar equivalents, of tert-butylamine in aqueous solution at a temperature between 10 °C and the boiling point of the solvent. Polymorphs of said intermediate, methods for preparation thereof and use thereof are also disclosed.
Patent NZ-614401-A (NZ)
Title: Automated control for detection of flow limitation
Inventor: ARMITSTEAD PETER JEFFREY
IPC: A61M16/00
Filed: 2008-05-09
Abstract: Disclosed is a method for determining a change in treatment, to be performed by a device for treating sleep-disordered breathing. The method includes determining a first measure of a degree of partial obstruction from a measure of respiratory flow and determining a second measure of a respiratory parameter from the measure of respiratory flow. The second measure of partial obstruction is either a breath duty cycle measure or a ventilation measure based on a tidal volume calculation. The method also includes adjusting the first measure with the second measure to qualify the degree of partial obstruction by the respiratory parameter and determinng a change in treatment based on the qualified degree of partial obstruction.
Patent NZ-701297-A (NZ)
Title: Bulk storage container and bulk material handling assembly therewith
Inventor: GALLAGHER PHIL
IPC: B65G69/18
Filed: 2013-04-24
Abstract: An intermediate bulk storage container (1) for the storage or transport of particulate catalyst material comprises a vessel (2) having an inner wall defining a containment volume for particulate catalyst material. The vessel (20) comprises a cylindrical wall section (22), a top panel (28) closing the upper end of the cylindrical wall section (22) and a conical base section (24) connected to and tapering inwardly away from the lower end of the cylindrical wall section (22). An opening (30) is provided in the top panel (28) of the container (20) for receiving the catalyst material and a closure member (32) is provided for closing the opening (30). An air tight seal is provided when the opening (30) is closed by the closure member (32). A gas duct (38) is in fluid connection with the vessel (20) for supplying an inert gas to the sealed container (20) or removing gas from the vessel (20) to place the container (20) under a vacuum to mitigate the risk of combustion. The gas duct is closed by a valve (40) for transit or storage.
Patent NZ-704736-A (NZ)
Title: Rotor having freewheel
Inventor: RIEDE HANS-JÜRGEN
IPC: A47J43/10
Filed: 2013-07-17
Abstract: A need exists for an operative insert for processing foodstuffs that can be used with a variety of drive mechanisms and/or increases the variability of processing options. The present disclosure relates to an operative insert (10) for a device for processing foodstuffs comprising such an operative insert, which has a receptacle for the operative insert which is driven in rotation about an axis of rotation (R) and to which the operative insert (10) can be releasably fastened in a torque-locking manner with a drive interface (20), wherein the operative insert (10) bears at least one working means (31, 32), which can be driven rotatably in a working direction by the drive interface (20) and can be uncoupled therefrom in relation to the rotational movement by a freewheel (40) upon reversal of the direction of rotation of the drive interface (20). A support spindle (60) bears the at least one working means (31, 32). The support spindle (60) can be driven rotatably in a working direction by the drive interface (20) and can be uncoupled therefrom in relation to the rotational movement by the freewheel upon reversal of the direction of rotation of the drive interface (20).
Patent NZ-707683-A (NZ)
Title: Flexible package and method of making the same
Inventor: SANFILIPPO JAMES J
IPC: B31B70/04
Filed: 2013-10-25
Abstract: An apparatus and method for manufacting aflexible, stackable, recloseable container (12) that provides reliable sealing when exposed to contamination. The flexible, stackable, recloseable container (12) for storing a quantity of products may comprise a plurality of walls (16) defined by a first sheet (14) and a second sheet (24) attached to at least a portion of the first sheet. The second sheet extends over at least three of the walls. The opposing container walls each have a sealed portion and one or more tucks (650), the tucks comprising a portion of the first sheet tucked toward the interior volume. A portion of the second sheet defines a recloseable feature (623) located over an opening for reclosing the container. The second sheet includes a line of reduced strength (658) at or adjacent at least a boundary adjacent the tucks and disposed between the opposing container walls each having the sealed portion and an adjacent container wall. The second sheet can include a hinge about which the recloseable feature pivots from closed position to open position.
Patent NZ-730247-A (NZ)
Title: Antibodies to ticagrelor and methods of use
Inventor: BUCHANAN ANDREW
IPC: C07D487/04
Filed: 2015-09-30
Abstract: The disclosure generally provides antibodies and antigen binding fragments of antibodies that bind ticagrelor and metabolites of ticagrelor. The disclosure also provides compositions comprising the antibodies, nucleic acid molecules encoding the antibodies, methods of treating a patient comprising administering the antibodies, and methods of making and using the antibodies.
Patent NZ-732537-A (NZ)
Title: Starch-based clouding agent for powdered beverages
Inventor: HIRT STACEY
IPC: A23L2/39
Filed: 2015-12-15
Abstract: Disclosed are maltodextrin-based powdered clouding agents for dry beverage mixes and beverage mixes including such powdered clouding agents. The maltodextrin-based powdered clouding agent consists of only retrograded dent corn maltodextrin having a dextrose equivalent (DE) value of 5-10, and is free of titanium dioxide (TiO2). Methods of preparing the powdered clouding agent that is free of titanium dioxide and other starch-based clouding ingredients are disclosed. The powdered clouding agents is added at 0.1-4 w% to a dry beverage mix that may form a beverage having an opacity substantially the same as a comparable natural beverage when reconstituted with water.
Patent NZ-738362-A (NZ)
Title: Display system with optical elements for in-coupling multiplexed light streams
Inventor: KLUG MICHAEL
IPC: G02B30/60
Filed: 2016-06-14
Abstract: A display system, such as, for example, a wearable virtual reality or augmented reality display system, may include a waveguide which in-couples light with image information and outputs the light to a viewer to form images in the eye of the viewer. Architectures are provided for selectively in-coupling one or more streams of light from a multiplexed light stream into a the waveguide. The multiplexed light stream can have light with different characteristics (e.g., different wavelengths and/or different polarizations). The waveguide can comprise in-coupling elements that can selectively couple one or more streams of light from the multiplexed light stream into the waveguide while transmitting one or more other streams of light from the multiplexed light stream. Advantageously, different light streams with different image information may effectively be routed to the viewer.
Patent NZ-740981-A (NZ)
Title: Battery system
Inventor: MUENZEL JAN VALENTIN
IPC: H02H7/18
Filed: 2016-09-29
Abstract: The present invention is directed to a circuit module for coupling a plurality of battery cell units. The circuit module includes a first set of terminals having a positive terminal and a negative terminal for coupling to a first battery cell unit, and a second set of terminals having a positive terminal and a negative terminal for coupling to a second battery cell unit. The positive terminal of the first set of terminals is coupled to the negative terminal of the second set of terminals either directly or via one or more passive components, and the negative terminal of the first set of terminals and the positive terminal of the second set of terminals each is coupled to a switching assembly. The switching assembly is operatively configured to selectively connect or disconnect each one of the battery cell units. The invention is also directed to a battery system including the circuit module and a plurality of battery cell units.
Patent NZ-758881-A (NZ)
Title: Patient interface and method for making same
Inventor: SMART GREGORY SCOTT
IPC: A61M16/06
Filed: 2014-11-14
Abstract: A patient interface to provide breathable gas to a patient at a therapeutic pressure of between 4cmH2O and 30cmH20, the patient interface comprising: a seal-forming structure and a plenum chamber formed in one piece, the seal-forming structure being configured to seal against an inferior periphery of the patient’s nose; an upper retaining structure and a lower retaining structure that are discontinuous structures attached to the plenum chamber separately from one another to form a gap between the upper retaining structure and the lower retaining structure on each lateral side of the plenum chamber such that the plenum chamber is more compressible at each gap; a frame comprising a connection port configured to connect to a gas delivery tube, the frame being configured to releasably connect to the upper retaining structure and to the lower retaining structure, and the frame comprising a gas washout vent configured to allow patient exhaled carbon dioxide to flow to atmosphere to minimise rebreathing of carbon dioxide by the patient; and a positioning and stabilising structure connected to the frame and configured to maintain the seal-forming structure in sealing contact with the patient; wherein the plenum chamber includes a plenum chamber hole and a sealing lip that extends into the plenum chamber hole to seal against the frame when the frame is releasably connected to the upper retaining structure and to the lower retaining structure.
Patent PT-100169-A (PT)
Inventor: ZDEPSKI JOEL WALTER
IPC: H04N21/63
Filed: 1992-02-26
Abstract: Apparatus for encoding/decoding a HDTV signal for e.g., terrestrial transmission includes a compression circuit responsive to high definition video source signals for providing ierarchically layered codewords CW representing compressed video data and associated codewords T, defining the types of data represented by the codewords CW. A priority selection circuit, responsive to the codewords CW and T, parses the codewords CW into high and low priority codeword sequences wherein the high and low priority codeword sequences correspond to compressed video data of relatively greater and lesser importance to image reproduction respectively. A transport processor, responsive to the high and low priority codeword sequences, forms high and low priority transport blocks of high and low priority codewords respectively. Each transport block includes a header, codewords CW and error detection check bits. The respective transport blocks are applied to an forward error check circuit for applying additional error check data. Thereafter the high and low priority data are applied to a modem wherein they quadrature amplitude modulate respective carriers for transmission.
Patent RU-94015060-A (RU)
Inventor: ROLDUGIN G N
IPC: B22D41/02
Filed: 1994-04-25
Abstract: FIELD: production of refractory lining of cake-cemented blocks used in metallurgical industry for steel casting ladles. SUBSTANCE: method involves subjecting cake-cemented blocks placed in refractory lining to firing by high-temperature flame torch with simultaneous blowing the lining with carbon-containing gas and subsequent blowing it with inert gas after termination of firing process. EFFECT: enhanced operating properties of lining.
Patent RU-94020922-A (RU)
Inventor: SAVIN A V
IPC: G08B3/00
Filed: 1994-06-03
Abstract: FIELD: security devices. SUBSTANCE: method involves playback of voice message to visitor in response to signal that visitor is located at entrance of monitored area. Said voice message contains information request for example about its identity or goal of its visit. Method is implemented by means of device for information exchange. It has device for playback of voice message to visitor in response to signal that visitor is located at entrance of monitored area. Said device is connected to or has information carrier which stores voice message which contains information request to visitor. EFFECT: increased security, increased functional capabilities.
Patent RU-94021991-A (RU)
Inventor: BIJUSHKIN N P
IPC: G09B23/18
Filed: 1994-06-09
Abstract: FIELD: testing equipment; may be used for experimental evaluation of lightning resistance of various objects (aircraft, motor vehicles, high-voltage power lines, various structures, etc). SUBSTANCE: method lies in generation of pulse of current from electric discharge plant and in its successive passing over tested object. Pulse of current is generated by blast-magnetic cumulation. After this peaking of pulse of current is conducted at moment of its maximum by electric blast of conductors which is transformed into fast-growing pulse of current of lightning which is then passed over tested object. EFFECT: possibility of modelling of lightning discharge in autonomous field conditions.
Patent RU-94033103-A (RU)
Inventor: LI VON-CHION
IPC: H04B7/26
Filed: 1994-09-12
Abstract: FIELD: radio communications. SUBSTANCE: system has local subsystems with movable users, base stations, and switchboards, and also ordered territorial group radio communication system incorporating controller for a number of local systems that functions to control level of transmitted radio signals and to provide communication when movable users change their position that determines scope of services provided for movable users. EFFECT: improved design.
Patent RU-94035246-A (RU)
Inventor: RJABCHIKOV A A
IPC: C01B21/26
Filed: 1994-09-21
Abstract: FIELD: chemical engineering. SUBSTANCE: platinoid catalyst used in production of nitric and hydrocyanic acids to oxidize component of original gas consists of a screen packet provided that those screens are installed the first in direction of gas passage which have braid size less than 1024 and their number is more than 6 pieces per 1 sq.cm, gas temperature being up to 973 K. EFFECT: improved catalyst structure. 1 dwg, 1 tbl