baber/WOPTO huggingface dataset:
Patent ES-2305434-T3 (ES)
Title: Composiciones framaceuticas de dispersiones amorfas de farmacos y materiales que forman microfases lipofilas.
Inventor: PERLMAN MICHAEL ELLIS
IPC: A61K9/14
Filed: 2003-01-28
Granted: 2008-11-01
Abstract: Una composición que comprende: (a) una dispersión amorfa sólida que comprende un fármaco de baja solubilidad y un polímero que aumenta la concentración, seleccionándose dicho polímero que aumenta la concentración entre el grupo constituido por acetato succinato de hidroxipropilmetilcelulosa, ftalato de hidroxipropilmetilcelulosa, acetato ftalato de celulosa, acetato trimelitato de celulosa, carboximetiletilcelulosa, hidroxipropilmetilcelulosa, poloxámeros, polivinilpirrolidona, poli (alcoholes vinílicos) que tienen al menos una parte de sus unidades de repetición en forma no hidrolizada, y mezclas de los mismos; (b) un material que forma una microfase lipófila, teniendo dicha composición una proporción en masa de dicho material que forma una microfase lipófila a dicho fármaco de baja solubilidad de 0,1 a 100; (c) dicho material que forma una microfase lipófila está presente en una cantidad suficiente de manera que dicha composición proporciona un aumento de la concentración de dicho fármaco en un entorno de uso de al menos 1,25 veces respecto a ambas primera composición de control y una segunda composición de control; en el que (i) dicha primera composición de control está compuesta esencialmente por una cantidad equivalente de dicha dispersión amorfa sólida sin que esté presente el material que forma una microfase lipófila; (ii) dicha segunda composición de control está compuesta esencialmente por una cantidad equivalente de dicho fármaco de baja solubilidad en forma no dispersada con una cantidad equivalente de dicho material que forma una microfase lipófila pero sin polímero que aumenta la concentración; en el que dicha dispersión amorfa sólida y dicho material que forma una microfase lipófila están presentes ambos en una sola forma de dosificación que es un comprimido oral o cápsula; en el que dicho material que forma una microfase lipófila comprende del 10% en peso al 80% en peso de dicha forma de dosificación; y en el que dicho material que forma una microfase lipófila se selecciona entre el grupo constituido por mezclas de aceites de ricino polietoxilados y gliceril mono-, di-, y/o tri-alquilatos de cadena media; mezclas de ésteres de ácido graso de polioxietilen sorbitano y gliceril mono-, di-, y/o tri-alquilatos de cadena media; mezclas de aceites de ricino polietoxilados y ésteres de sorbitano, mezclas de ácido taurocólico sódico y palmitoil-2-oleil-sn-glicero-3-fosfocolina y otras fosfatidil colinas naturales o sintéticas; y mezclas de glicéricos poliglicolizados y gliceril mono-, di-, y/o tri-alquilatos de cadena media.
Patent ES-2283759-T3 (ES)
Inventor: GOETSCH LILIANE
IPC: C12P21/08
Filed: 2003-01-20
Granted: 2007-11-01
Abstract: An isolated antibody (Ab), and its functional fragments, that bind to human insulin-like growth factor-1 receptor (IGF-1R) and optionally: (i) inhibit natural binding of insulin-like growth factors (IGF)-1 and/or -2; and/or (ii) inhibit specifically tyrosine kinase activity of IGF-1R. An isolated antibody (Ab), and its functional fragments, that bind to human insulin-like growth factor-1 receptor (IGF-1R) and optionally inhibit natural binding of insulin-like growth factors (IGF)-1 and/or -2 and/or inhibit specifically tyrosine kinase activity of IGF-1R, is new. Ab comprises: (a) a light chain containing at least one complementarity-determining region (CDR) of one of 3 fully defined sequences comprising 16, 7 or 9 amino acids as given in the specification; or (b) a heavy chain containing at least one of the CDRs of one of 3 fully defined sequences comprising 6, 16 or 8 amino acids as given in the specification or sequences with 80% identity after optimal alignment. Independent claims are also included for the following: (1) murine hybridomas that secrete Ab; (2) an isolated nucleic acid (I) that: (a) is RNA or DNA and encodes Ab or its fragments; (b) is the complement of (a); or (c) has at least 18 nucleotides that can hybridize under stringent conditions with any of six sequences fully defined in the specification that encode the specified CDR, or with sequences having 80% identity after optimal alignment; (3) a vector containing (I); (4) a host cell containing the vector of (3); (5) a non-human transgenic animal containing at least one cell transfected with the vector of (3); (6) producing Ab or its fragments; (7) in vitro diagnosis of diseases induced by over- or under-expression of IGF-1R and or EGFR (epidermal growth factor receptor) by reaction with optionally labeled Ab; and (8) kit for performing method (7). ACTIVITY : Cytostatic; Antipsoriatic. The murine antibody 7C10, specific for IGF-1R, was tested (at 250 Microgram twice a week, intraperitoneally) against MCF-7 breast cancer cells, implanted in nude mice. After 37 days, the mean tumor volume was about 150 mm 3>; compared to about 800 mm 3> for controls and 300 mm 3> for animals treated with 10 Microgram tamoxifen. MECHANISM OF ACTION : Inhibition of signal transduction pathways mediated by IGF-1R, optionally also by epidermal growth factor (EGF) receptor, thus inhibiting growth and/or proliferation of tumor cells, especially where dependent on IGF, EGF, estrogens and/or HER2/neu.
Patent ES-2270022-T3 (ES)
Inventor: MCVEY IAIN F
IPC: A62D3/115
Filed: 2003-04-24
Granted: 2007-04-01
Abstract: An oxidizing liquid (20), such as hydrogen peroxide, is vaporized (18) and the vapor is used to deactivate nerve gas, blistering gas, or other biologically active substances such as pathogens, biotoxins, and prions. A second chemical compound (42) in vapor, mist, or fog form is used in conjunction with the oxidizing vapor. In one embodiment, the second chemical preconditions the biologically active substances to be deactivated more efficiently by the oxidizing vapor. In another embodiment, the second chemical boosts the reactivity of the oxidizing vapor. In another embodiment, the other chemical reacts with the oxidizing vapor to form an intermediate compound that deactivates at least some of the biologically active substances.
Patent ES-2274259-T3 (ES)
Inventor: THOMSON AXEL ANDREAS
IPC: A61K31/435
Filed: 2003-09-17
Granted: 2007-05-16
Abstract: A method of protecting a patient from possible adverse effects of a treatment involving inhibition of the SHH-signalling pathway in the patient, the method comprising suppressing testosterone or its effect in the patient. A method of treating a proliferative disease such as cancer in a patient the method comprising inhibiting the SHH-signalling pathway and suppressing testosterone or its effect in the patient. Typically, the SHH-signalling pathway is inhibited using cyclopamine or a derivative thereof, and testosterone is suppressed using any one or more of a GnRH antagonist, a GnRH agonist, an androgen antagonist or a Sa-reductase inhibitor.
Patent ES-2297208-T3 (ES)
Title: Metodo para la investigacion de moduladores del funcionamiento mitocondrial.
Inventor: JACOTOT ETIENNE
IPC: C07K14/00
Filed: 2003-10-02
Granted: 2008-05-01
Abstract: Péptido que tiene el potencial de modulación de la Permeabilización de la Membrana Mitocondrial (MMP) teniendo la Secuencia ID Nº 7: RIAIWILRH.
Patent ES-2357507-T3 (ES)
Inventor: AMMERMANN EBERHARD
IPC: A01N43/32
Filed: 2003-06-30
Granted: 2011-04-27
Abstract: The invention relates to fungicidal mixtures containing, in a synergistically effective amount: A) the compound of formula (I), and; B) at least one imidazole derivative of formula (II), in which R<1> and R<2> represent halogen and phenyl, which can be substituted by halogen or alkyl, or R<1> and R<2>, together with the bridging C=C double bond, form a 3,4-difluoromethylene dioxyphenyl group; R<3> represents cyano or halogen, and; R<4> represents dialkylamino or isoxazol-4-yl that can carry two alkyl radicals. The invention also relates to methods for controlling harmful fungi by using mixtures of compounds (I) and (II), and to the use of compounds (I) and (II) for producing mixtures of this type.
Patent ES-2311739-T3 (ES)
Inventor: VAN DER LEEST ADRIANUS JOHANNES WILHELMUS
IPC: F16H61/662
Filed: 2003-12-10
Granted: 2009-02-16
Abstract: Continuously variable transmission provided with a primary pulley and a secondary pulley, around which a drive belt is arranged, clamped between two conical pulley discs of the respective pulley, a running surface of at least one pulley disc of the primary pulley and the secondary pulley, via which running surface this pulley disc contacts the drive belt, being provided, as seen in a cross section oriented perpendicular to a tangential direction, with a curvature, so that a pulley angle between a tangent on the running surface and a radial direction varies between a lowest value at the location of a radially innermost position on the running surface and a highest value at the location of a radially outermost position on the running surface. The curvature of the running surface of the primary pulley and that of the running surface of the secondary pulley differ from one another.
Patent ES-2383296-T3 (ES)
Inventor: XUE CHU-BIAO
IPC: C07D405/08
Filed: 2003-11-26
Granted: 2012-06-20
Abstract: The present invention relates to 3-aminopyrrolidine derivatives of the formula I:   
(wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
Patent ES-2371003-T3 (ES)
Inventor: KOSAKA MASAHISA
IPC: G02C7/02
Filed: 2004-09-09
Granted: 2011-12-26
Abstract: The invention provides a process of producing a plastic lens having a high refractive index, a high Abbe's number and a further good mechanical strength and a plastic lens obtainable by that process.
Patent ES-2349689-T3 (ES)
Title: Procedimiento para convertir aceites crudos pesados y coque de petróleo en gas de síntesis usando una fuente de radiación externa.
Inventor: MORALES ALFREDO
IPC: C10G32/00
Filed: 2004-10-01
Granted: 2011-01-10
Abstract: Un procedimiento para conversión termoquímica de aceite pesado y coque de petróleo en combustibles fluidos, que comprende las etapas de: proporcionar un combustible fósil seleccionado del grupo que consiste en aceite pesado, coque de petróleo y mezclas de los mismos y exponer el combustible fósil a una fuente externa de radiación concentrada en presencia de un oxidante a fin de aumentar la temperatura del combustible fósil a una temperatura de al menos aproximadamente 1.000ºC y convertir el combustible fósil en un producto que consiste esencialmente en hidrógeno y monóxido de carbono.
Patent ES-2290601-T3 (ES)
Inventor: HEITMANN THOMAS
IPC: F42B10/66
Filed: 2004-10-05
Granted: 2008-02-16
Abstract: A control unit for the flight path of a projectile, comprises a control block (3) with holders (5) for a propellant (4). Each holder has an ignition element (7) for the propellant, with at least one contact element (10,11) connected to an electronic control unit via a cable (17,18). The control block has a central cut out which contains a tubular carrier for the cable. The carrier consists of an electrically insulating material.
Patent ES-2288242-T3 (ES)
Inventor: KLASSEN GERHARD D
IPC: G06Q10/00
Filed: 2004-06-03
Granted: 2008-01-01
Abstract: A method implemented at a communication device of displaying a message to a user. The device comprises a plurality of messaging modules, each messaging module being associated with one of a plurality of message transports. The method comprises the steps of: receiving a message via a first message transport; passing the received message to a first messaging module corresponding to the first message transport; determining, by the first messaging module, the message type of the received message. If the received message is a message type normally associated with the first message transport, the method comprises processing the received message using the first messaging module and presenting the received message to the user using the first messaging module. If the received message is not a message type normally associated with the first message transport: the method comprises processing, by the first messaging module, the transport-dependent portions of the received message; passing the processed message to a second messaging module normally associated with the message type of the received message; further processing, by the second messaging module, the processed message; and presenting the received message to the user using the second messaging module.
Patent ES-2312928-T3 (ES)
Inventor: HOLLOWAY WYNN PETER
IPC: E04B7/20
Filed: 2004-03-25
Granted: 2009-03-01
Abstract: A roofing panel 110 for a pitched roof comprises a rectangular frame 111 having both faces covered in board material 116 ,117, the frame 111 comprising top and bottom rails 112,113 joined together by a plurality of composite "I" beams 10 & 41. The panel 110 is provided with elongate attachment means 101,102 at its upper and lower ends for attachment to, for example, a roof beam 65 and guttering respectively. The attachment means 101,102 have a right angle triangular portion with an apex angle  alpha , beta  substantially equal to the pitch angle of the roof, a base side 51,61 for securing to the top or bottom of the panel 110 and a hypotenuse 53,63 which in use is substantially vertical. <IMAGE>
Patent ES-2267004-T3 (ES)
Title: Alquildienamidas como potencadoras del gusto y de efectos organolepticos en composiones de aroma.
Inventor: DEWIS MARK L
IPC: A23L27/00
Filed: 2004-04-08
Granted: 2007-03-01
Abstract: Un proceso para aumentar, potenciar o impartir un gusto o un efecto somatosensorial a un producto comestible, chicle, producto medicinal, pasta dentífrica, bebida alcohólica, bebida acuosa o sopa que comprende la etapa de añadir al producto comestible, chicle, producto medicinal, pasta dentífrica, bebida alcohólica, bebida acuosa o sopa una cantidad y concentración que aumenta, potencia o imparte sabor o una sensación, de al menos una alquil amida alifática insaturada sustituida en N definida según la estructura: en la que: R es metilo, etilo, n-propilo, isopropilo, ciclopropilo, n- butilo, sec-butilo, isobutilo, ciclobutilo, CH2CH(CH3)CH2CH3, CH2CH(OH)CH3, CH(CH3)CH2OH, CH2C(CH3)2OH, CH2CH2OH, ciclopentilo o alilo; y R¿ es metilo, etilo, n-propilo, n-butilo, n-pentilo o n- hexilo.
Patent ES-2306986-T3 (ES)
Title: Masa autoadhesiva electricamente calentable.
Inventor: HUSEMANN MARC
IPC: C09J7/10
Filed: 2004-02-18
Granted: 2008-11-16
Abstract: Masa autoadhesiva eléctricamente calentable, que incluye (a) al menos un componente adhesivo y (b) al menos una carga eléctricamente conductora, caracterizada porque la carga usada como mínimo es un negro de humo eléctricamente conductor.
Patent ES-2392829-T3 (ES)
Inventor: FLETCHER TREVOR LEE
IPC: F01N3/28
Filed: 2004-03-01
Granted: 2012-12-14
Abstract: An exhaust system (10) for an engine system, the exhaust system (10) comprising a pipe system (12) having at least one input port (15, 16) for receiving exhaust gases from the engine (14) system and at least one output port (18) for venting exhaust gases from the exhaust system (10) wherein the pipe system (12) includes at least two exhaust routes for flow of gases from the one or more input ports (15, 16) to the one or more output ports (18), and further includes a diverter valve (28) operable in response to a control input to control the flow of exhaust gases through the pipe system (12) through one or more of the exhaust routes, the diverter valve (28) comprising at least two butterfly valve members (36), each butterfly valve member (36) controlling the flow of exhaust gases via one of said exhaust routes, each member having an input face (21) and an output face (23), at least one input face (21) comprising input disrupting means (50) for disrupting the flow of exhaust gases emitted from the engine (14) system.
Patent ES-2379689-T3 (ES)
Inventor: WINKLER DAVID G
IPC: A61K/
Filed: 2004-03-12
Granted: 2012-04-30
Abstract: Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta binding protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.
Patent ES-2307019-T3 (ES)
Title: Disposicion de apoyo para un vehiculo automovil.
Inventor: KRONER GREGOR
IPC: B60N2/68
Filed: 2004-06-14
Granted: 2008-11-16
Abstract: Disposición de apoyo para un dispositivo de ajuste en un vehículo automóvil, con - un punto de apoyo en forma de una abertura de apoyo en una pieza base y - un elemento de apoyo que pasa por la abertura de apoyo, caracterizada porque la pieza base (S, T) presenta en el borde (10) de la abertura de apoyo (1) por lo menos una zona de deformación (11, 12, 13, 14, 14a, 14b, 14c) que debido a una deformación plástica sobresale del borde (10) radialmente hacia dentro y actúa como soporte radial para el elemento de apoyo (2).
Patent ES-2324668-T3 (ES)
Title: Metodo y dispositivo para la fabricacion de productos de acero recubiertos de metal.
Inventor: DE MEYER MARIJKE
IPC: C23C2/26
Filed: 2004-09-23
Granted: 2009-08-12
Abstract: Un método para la fabricación de productos de acero recubiertos de metal, comprendiendo los pasos de: - proveer un producto de acero con un recubrimiento metálico, - añadir un elemento metálico adicional a dicho recubrimiento, seguido de un paso de - someter dicho producto a un tratamiento térmico, caracterizado porque: - antes del añadido de dicho elemento adicional, dicho producto es sometido a un tratamiento con plasma, para limpiar y activar la superficie de dicho recubrimiento, - dicho elemento adicional es añadido mediante una técnica de deposición física de vapor, - dicho tratamiento térmico es aplicado por radiación infrarroja de alta energía dirigida hacia la superficie externa de dicho recubrimiento, donde la densidad de energía de dicha radiación infrarroja es de al menos 400 Kw/m 2 .
Patent ES-2379356-T3 (ES)
Title: Procedimiento y dispositivo para el revestimiento del área de conexión entre al menos dos elementos alargados, en particular entre cables eléctricos
Inventor: VALLAURI UBALDO
IPC: H02G15/18
Filed: 2004-10-27
Granted: 2012-04-25
Abstract: Un procedimiento para el revestimiento del área de conexión (60) entre al menos dos elementos alargados (61, 62), comprendiendo dicho procedimiento las etapas de: - la disposición de un soporte tubular rígido (10) que tiene dos mitades tubulares (11, 12) separables en sentido axial; - la disposición de un elemento de estanqueidad anular circunferencialmente continuo entre dichas mitades (11, 12); - el montaje de un manguito tubular elástico (20) en un estado expandido radialmente de forma elástica, sobre una superficie externa (10a) de dicho soporte (10); - la interposición de un material lubricante (30) entre dicho soporte (10) y el manguito (20); - la colocación de dicho soporte (10) provisto de dicho manguito (20) alrededor de dicha área de conexión (60); y - la separación mutua de dichas mitades (11, 12) para posibilitar que dicho manguito tubular elástico (20) se aplaste sobre dicha área de conexión (60) .
Patent ES-2339025-T3 (ES)
Inventor: TILBROOK MATTHEW
IPC: A01N61/00
Filed: 2004-11-05
Granted: 2010-05-14
Abstract: A method of manufacture of soluble, microbiologically active and stable acrolein polymer comprising: (a) polymerising acrolein in the presence of base to form a polymer of acrolein; (b) dissolving the polymer of acrolein in an alcohol selected from monoalcohols and polyols optionally with addition of water to form an alcohol solution of the polymer of acrolein; (c) heating the alcohol solution of the polymer of acrolein; and (d) mixing base with the polymer of acrolein.
Patent ES-2640746-T3 (ES)
Title: Sistema catalizador para la (co)polimerización de etileno
Inventor: KONG GAPGOUNG
IPC: B01J31/02
Filed: 2004-11-16
Granted: 2017-11-06
Abstract: Un sistema catalizador eficaz para catalizar la (co)polimerización de α-olefina, comprendiendo el sistema catalizador un componente catalizador preparado: (a) haciendo reaccionar un compuesto que tiene la fórmula R3M con una amina que tiene un enlace nitrógeno-hidrógeno terminal y que contiene cuatro o más átomos de carbono, en la que R es un hidrocarburo C1-13 y M se selecciona del grupo que consiste en aluminio, boro, galio e indio; (b) haciendo reaccionar el producto de (a) con un compuesto de dialquilmagnesio; (c) haciendo reaccionar un compuesto que contiene un grupo dieno cíclico con un compuesto de metal de transición temprana, en el que el compuesto de metal de transición temprana tiene la fórmula M'OpR1qXr, en la que R1 es alquilo, X es halógeno, y p, q y r son números de 0 a 4, y M' es Ti; y (d) haciendo reaccionar el producto de (b) con el producto de (c); en el que dicho sistema catalizador comprende además un soporte de haluro de magnesio sólido y un cocatalizador de alquilaluminio, y en el que las reacciones (a) y (b) se llevan a cabo en un disolvente no polar.
Patent ES-2399050-T3 (ES)
Title: Anticuerpos contra interferón alfa y sus usos
Inventor: WITTE ALISON
IPC: C12N/
Filed: 2004-12-10
Granted: 2013-03-25
Abstract: Un anticuerpo monoclonal anti-interferón alfa aislado, o parte de unión a antígeno del mismo, que comprende: (a) una CDR1 de región variable de cadena pesada que comprende la SEC ID Nº 1; (b) una CDR2 de región variable de cadena pesada que comprende la SEC ID Nº 4; (c) una CDR3 de de región variable de cadena pesada que comprende la SEC ID Nº 7; (d) una CDR1 de región variable de cadena ligera que comprende la SEC ID Nº 10; (e) una CDR2 de región variable de cadena ligera que comprende la SEC ID Nº 13; y (f) una CDR3 de región variable de cadena ligera que comprende la SEC ID Nº 16.
Patent ES-2302085-T3 (ES)
Inventor: LUSCHER THOMAS
IPC: B23Q3/155
Filed: 2005-03-08
Granted: 2008-07-01
Abstract: The magazine (1) is of a cubic shape and comprises several stories (12), each containing five storage modules (13) arranged along a circle. A gripping arm (16) can be vertically moved along a central column (15) and radial towards the tool or work-piece exchange unit (6). The exchange unit (6) is fitted with a holding arm (7) moved by a computer controlled servo drive (9) joining the items to the spindle (2) connected to a vertically moving carriage (5).
Patent ES-2297580-T3 (ES)
Inventor: SAMAIN MAXIME
IPC: A47C7/46
Filed: 2005-09-12
Granted: 2008-05-01
Abstract: A support assembly having a first support region with adjustable degree of support and a second support region with adjustable degree of support for use in a seat structure is provided. The support assembly comprises a support member (3) for incorporation into a seat frame, a first Bowden cable arrangement (10a) for adjusting the degree of support in the first support region, and a second Bowden cable arrangement (10b) for adjusting the degree of support in the second support region. The support assembly further comprises an actuator (20) coupled to the first Bowden cable arrangement (10a) and to the second Bowden cable arrangement (10b), the actuator (20) being configured to simultaneously act on the first Bowden cable arrangement (10a) and on the second Bowden cable arrangement (10b) in opposite directions.