baber/WOPTO huggingface dataset:
Patent WO-2019210279-A1 (WO)
Title: De novo formation of the biliary system by hepatocyte transdifferentiation
Inventor: WILLENBRING HOLGER
IPC: A61K31/573
Filed: 2019-04-26
Abstract: The disclosure provides materials and methods useful in forming at least one bile duct or treating cholestatic disease or injury by transdifferentiating hepatocytes to cholangiocytes by delivery of an effective amount of an expressible Transforming Growth Factor β Type I Receptor (TGFBR1), Transforming Growth Factor β Type II Receptor (TGFBR2), SMAD3, SMAD1, SMAD2, SMAD5 or SMAD8/9, in either  in vivo  or  in vitro  environments. Another aspect provides a method of forming at least one bile duct or treating a cholestatic disease or injury by delivering an effective amount of JAG1, JAG2, DLL1, DLL3, DLL4, NOTCH1, NOTCH2, NOTCH3, NOTCH4 or the respective NOTCH intracellular domains either  in vivo  or  in vitro . Also provided are methods for correcting mutant alleles of genes in the ΤGFβ and/or Notch pathways,  e.g., JAG1  or  NOTCH2 , using ZFNs, TALENs, CRISPR or any other genome editing technique. Additionally, methods are provided for inducing increased expression of a normal, or wild-type, allele of a ΤGFβ or Notch pathway gene such as  TGFBR1  or  JAG1  using CRISPRa technology. Yet another aspect is drawn to a method of forming at least one bile duct or treating a cholestatic disease or injury by delivering an effective amount of a wild-type hepatocyte or a hepatocyte that has not been engineered to overexpress a gene product.
Patent WO-2019217129-A1 (WO)
Title: Efficient data encoding for deep neural network training
Inventor: PHANISHAYEE AMAR
IPC: G06N3/04
Filed: 2019-04-30
Abstract: Functions are added to a deep neural network ("DNN") computation graph for encoding data structures during a forward training pass of the DNN and decoding previously-encoded data structures during a backward training pass of the DNN. The functions added to the DNN computation graph can be selected based upon on the specific layer pairs specified in the DNN computation graph. Once a modified DNN computation graph has been generated, the DNN can be trained using the modified DNN computation graph. The functions added to the modified DNN computation graph can reduce the utilization of memory during training of the DNN.
Patent WO-2019236386-A1 (WO)
Title: Computing node failure and health prediction for cloud-based data center
Inventor: CHINTALAPATI MURALI M
IPC: G06F9/50
Filed: 2019-05-31
Abstract: A system may include a node historical state data store having historical node state data, including a metric that represents a health status or an attribute of a node during a period of time prior to a node failure. A node failure prediction algorithm creation platform may generate a machine learning trained node failure prediction algorithm. An active node data store may contain information about computing nodes in a cloud computing environment, including, for each node, a metric that represents a health status or an attribute of that node over time. A virtual machine assignment platform may then execute the node failure prediction algorithm to calculate a node failure probability score for each computing node based on the information in the active node data store. As a result, a virtual machine may be assigned to a selected computing node based at least in part on node failure probability scores.
Patent WO-2020091845-A1 (WO)
Inventor: TAN JUN
IPC: A61K31/575
Filed: 2019-06-05
Abstract: In one aspect, the disclosure relates to compositions of lithium cholesterol compositions, including, but not limited to, lithium cholesterol sulfate compositions which are useful as therapeutic agents. The disclosure also relates to methods of making lithium cholesterol compositions and pharmaceutical compositions comprising therapeutically effective amounts of the lithium cholesterol compositions. The present disclosure also includes compositions including lithium cholesterol compounds for use as a medicament and/or for use as in the treatment of one or more neurological conditions, such as, but not limited to Alzheimer's disease, autism spectrum disorder, bipolar disorder, or other neuropsychiatric disorders.
Patent WO-2020027920-A1 (WO)
Title: Dual engine-compressor system
Inventor: GAMBLE CHRISTOPHER L
IPC: F01B7/04
Filed: 2019-06-10
Abstract: The present invention is directed to a dual engine-compressor system having a crankcase enclosing a crankshaft and having engine cylinder housings and compressor cylinder housings linearly disposed on opposite sides of the crankcase. Combustion pistons are reciprocatingly disposed in the engine cylinder housings and defines alternating combustion chambers on opposite sides of the pistons. Compressor pistons are reciprocatingly disposed in the compressor housings and define alternating low and high pressure compressor chambers on opposite sides of the compressor pistons. The compressor pistons underdo a 4-cycle process to drawn in, re-distribute, and then compress fluid. The compressor cylinder and piston has a series of one-way intakes and reed valves to selectively draw or push fluid in response to movement of the compressor piston.
Patent WO-2020005535-A1 (WO)
Title: A highly conformable wound dressing
Inventor: SEDDON JAMES
IPC: A61F13/00
Filed: 2019-06-11
Abstract: In some examples, a dressing filler for treating a tissue site may include a plurality of filler elements and a tissue interface layer. Each of the filler elements may include a first surface and a second surface opposite the first surface and separated from the first surface by a thickness. The tissue interface layer may include a first side configured to be positioned facing the tissue site and a second side positioned opposite the first side. The first surface of each of the filler elements may be coupled to the second side of the tissue interface layer.
Patent WO-2020060622-A1 (WO)
Inventor: DIACONU CRISTIAN
IPC: H04L29/08
Filed: 2019-06-26
Abstract: Assembly of a state of user data as of a particular point in time in the context of the data being spread across multiple storage segment servers. Furthermore, the assembly occurs despite the storage segment servers not needing to coordinate a timing of any snapshots. Rather, the storage segment servers perform a snapshot of the portion of the data that it individually stores without having to coordinate with any other storage segment server. The particular point of time may be any arbitrary time, such as a time selected by a user.
Patent WO-2020023272-A1 (WO)
Inventor: MUSCARIELLO LUCA
IPC: H04L29/08
Filed: 2019-07-18
Abstract: Selon l'invention, un dispositif réseau dans un bord de réseau reçoit un contenu dirigé vers un dispositif mobile fixé au bord de réseau à partir d'un dispositif réseau en amont et transfère le contenu vers le dispositif mobile.
Le dispositif réseau prend une décision pour savoir s'il faut mettre en cache le contenu sur la base, au moins en partie, d'une popularité du contenu dans une région couverte par le dispositif de réseau et d'une erreur de prédiction pour une probabilité estimée que le dispositif mobile va passer de la région à une autre région.
La popularité est directement corrélée à un premier biais pour mettre en cache le contenu.
L'erreur de prédiction est mise en corrélation inverse avec une seconde polarisation pour mettre en cache le contenu.
La décision est mise en œuvre : le dispositif de réseau met en cache le contenu ou abandonne la mise en cache du contenu, conformément à la décision.
Patent WO-2020033736-A1 (WO)
Title: Apparatus and methods to adjust ocular blood flow
Inventor: BERDAHL JOHN
IPC: A61F9/00
Filed: 2019-08-08
Abstract: An apparatus to treat, inhibit, or prevent an eye condition in a patient can include a cover, sized and shaped to fit over an eye of a patient to define a cavity between the cover and an anterior surface of the eye when the cover is located over the patient eye. The apparatus can include a pressure source, in communication with the cavity, capable of applying non-ambient pressure in the cavity. The apparatus can include control circuitry, in communication with the pressure source, configured to vary non-ambient pressure applied to the cavity to affect a targeted pressure relationship between an indication of a first physiological pressure level and a second physiological pressure level associated with the eye of the patient.
Patent WO-2020060864-A1 (WO)
Inventor: NASER KARAM
IPC: H04N19/61
Filed: 2019-09-13
Abstract: At least a method and an apparatus are presented for efficiently encoding or decoding video using multiple transforms, such as, e.g., enhanced multiple transform (EMT), or multiple transform selection (MTS). For example, a horizontal transform and a vertical transform are selected from a set of transforms to transform prediction residuals of a current block of a video picture being encoded, wherein the set of transforms includes only pairs of: {DCT2, DCT2}, {DST7, DST7}, {DCT8, DST7}, {DST7, DCT8}. A syntax element is provided to indicate the selected horizontal transform and the selected vertical transform selected from the set of transforms. The prediction residuals of the current block are transformed using the selected horizontal transform and the selected vertical transform to obtain transformed coefficients for the current block. The syntax element and the transformed coefficients of the current block are encoded accordingly.
Patent WO-2020214199-A1 (WO)
Inventor: GOODWIN JUSTIN
IPC: F22G5/12
Filed: 2019-09-17
Abstract: A spray nozzle assembly has a housing with a body and cap flange secure to the body to define a bore within the housing. A first aperture is formed through the body and intersects the bore and a second aperture is formed through the cap flange and intersects the bore. A nozzle sleeve is disposed within the bore and has a solid, unitary sleeve body. First and second fluid passages are formed through the sleeve body. The first fluid passage is in fluid communication with the first aperture and a first exit aperture in an end of the sleeve body. The second fluid passage is in fluid communication with the second aperture and second and third exit apertures in the end of the sleeve body, which are positioned on opposite sides of the first exit aperture. A portion of the second fluid passage surrounds the first fluid passage.
Patent WO-2020131184-A1 (WO)
Title: Diagnostic d'ascenseurs à gaz par ondes de pression acoustique
Inventor: ROMER MICHAEL
IPC: E21B43/12
Filed: 2019-09-25
Abstract: L'invention porte sur un procédé d'identification et de diagnostic des vannes de levage de gaz ouvertes dans un puits de production par levage de gaz, le puits de production par levage de gaz comprenant un tubage de production comportant une pluralité de vannes de levage de gaz mécaniques, et un tubage entourant une partie du tubage pour former un anneau. Le procédé consiste : réduire la pression d'injection en-dessous de la pression d'ouverture nominale minimale de chaque vanne de la pluralité de vannes de levage de gaz mécanique pour fermer chacune de la pluralité de vannes de levage de gaz mécaniques ; augmenter de manière incrémentielle la pression d'injection jusqu'à la pression d'injection de fonctionnement ou nominale pour ouvrir de manière séquentielle une ou plusieurs de la pluralité de vannes de levage de gaz mécanique ; la mesure de la pression, de l'amplitude, de la fréquence et/ou des motifs d'onde produits par l'ouverture séquentielle de l'ou des vannes de levage de gaz mécaniques; et déterminer l'emplacement du ou des emplacements de vanne de levage de gaz mécaniques.
Patent WO-2020097488-A1 (WO)
Title: Parallel electrodes sensor
Inventor: SARIOGLU ALI FATIH
IPC: C12M3/00
Filed: 2019-11-08
Abstract: Systems and methods to integrate electrical sensors comprising parallel electrodes into microfluidic devices that are manufactured using soft lithography are disclosed herein. With minimal fabrication complexity, more uniform electric fields than conventional coplanar electrodes are produced. The methods disclosed are also more suitable for the construction of complex electrical sensor networks in microfluidic devices due to greater layout flexibility and provide improved sensitivity over conventional coplanar electrodes.
Patent WO-2020097535-A1 (WO)
Inventor: LUCAS SCOTT ANDREW
IPC: G06Q40/04
Filed: 2019-11-08
Abstract: Systems and methods for distributed ledger-based intraday trading are disclosed. In one embodiment, a method may include: receiving a digital representation of an amount of collateral for a cash borrower; receiving a digital representation of an amount of cash for a cash provider; receiving agreement from the cash borrower and the cash provider to terms of an intraday trade comprising a duration of the intraday trade, a collateral trade amount of the collateral, and a cash trade amount of cash; a smart contract executing the intraday trade by providing the trade amount of the digital collateral to the cash provider and the cash trade amount of the digital cash to the cash borrower; and the smart contract returning the trade amount of the digital collateral to the cash borrower and the cash trade amount of the digital cash to the cash provider at the completion of the intraday trade.
Patent WO-2020131770-A1 (WO)
Inventor: WANG RUOYA
IPC: A61B18/14
Filed: 2019-12-17
Abstract: Sonde d'ablation radiofréquence refroidie comprenant un ensemble électrocapuchon comprenant un élément allongé ayant un corps, une extrémité proximale conçue pour faire l'interface avec une poignée de sonde, et une extrémité distale thermo- et électroconductrice conçue pour délivrer de l'énergie électrique ou radiofréquence au tissu d'un patient. L'élément allongé loge au moins un tube de fluide de refroidissement sur la longueur du corps et un hypotube de thermocouple sur longueur de l'élément allongé. Le corps et l'extrémité proximale de l'élément allongé sont droits, et l'extrémité distale de l'élément allongé est incurvée. L'invention concerne également un kit d'administration d'ablation radiofréquence refroidie comprenant une sonde radiofréquence, un introducteur et un stylet.
Patent WO-2020132137-A1 (WO)
Inventor: JEYAKUMAR SANJAY
IPC: G06F21/55
Filed: 2019-12-18
Abstract: Les services de filtrage de courriers électroniques classiques ne sont pas appropriés pour reconnaître des courriers électroniques malveillants sophistiqués, et peuvent par conséquent permettre à des courriers électroniques malveillants sophistiqués d'atteindre des boîtes de réception par erreur. L'invention concerne des plates-formes de détection de menaces conçues pour suivre une approche globale pour détecter des menaces de sécurité. Par exemple, après la réception d'une entrée indiquant une approbation en provenance d'un individu pour accéder à un courrier électronique passé reçu par des employés d'une entreprise, une plateforme de détection de menaces peut télécharger des courriers électroniques passés pour construire un modèle d'apprentissage machine (ML) qui comprend les normes de communication avec des contacts internes (par exemple, d'autres employés) et/ou des contacts externes (par exemple, des vendeurs). En appliquant le modèle de ML au courrier électronique entrant, la plate-forme de détection de menaces peut identifier des menaces de sécurité en temps réel de manière ciblée.
Patent WO-2020146451-A1 (WO)
Title: Réseaux de bragg volumiques pour écran à guide d'ondes près de l'œil
Inventor: LEE HEE
IPC: G02B5/18
Filed: 2020-01-08
Abstract: La présente invention concerne un écran à guide d'ondes comprenant un substrat transparent à la lumière visible, un coupleur configuré afin de coupler une lumière d'affichage dans le substrat de telle sorte que la lumière d'affichage se propage à l'intérieur du substrat par réflexion interne totale, un premier réseau de Bragg volumique (VBG) multiplexé sur le substrat, et un second VBG multiplexé sur le substrat. Le second VBG multiplexé chevauche le premier VBG multiplexé dans au moins une région transparente de l'écran à guide d'ondes. Le premier VBG multiplexé est configuré afin de diffracter la lumière d'affichage vers au moins deux régions du second VBG multiplexé, et le second VBG multiplexé est configuré afin de diffracter la lumière d'affichage vers au moins deux régions d'un boîtier oculaire de l'écran à guide d'ondes.
Patent WO-2020150457-A1 (WO)
Inventor: THOMPSON SAMUEL
IPC: C02F1/28
Filed: 2020-01-16
Abstract: The present disclosure provides novel solid sorbents synthesized by the reaction of polyamines with polyaldehyde phosphorus dendrimer (P-dendrimer) compounds for metal sequestration. The sorbents are highly stable and exhibit desirable thermodynamics and reaction kinetics with a wide variety of metals including heavy metals and rare earth elements. The sorbents can be easily regenerated for repeated use to extract metals from an aqueous solution. The materials are stable to aqueous and organic media, as well as strong acid and bases. The sorbents maintain full capacity over many cycles of use.
Patent WO-2020159963-A1 (WO)
Inventor: WARD ANTHONY
IPC: A61K39/00
Filed: 2020-01-28
Abstract: La présente invention concerne des procédés améliorés de préparation de cellules et de compositions à des fins thérapeutiques.
Patent WO-2020163132-A1 (WO)
Inventor: SRINIVASAN SATISH
IPC: H01J37/32
Filed: 2020-01-29
Abstract: L'invention concerne un composant destiné à être utilisé dans une chambre de traitement, le composant étant exposé à un plasma dans la chambre de traitement. Le composant comprend une couche de carbure de silicium et une couche de revêtement sur la couche de carbure de silicium, la couche de revêtement comprenant au moins un élément choisi parmi le tungstène, le tantale ou le bore.
Patent WO-2020163655-A1 (WO)
Title: Bactéries productrices de minicercle conçues pour produire de manière différentielle des molécules d'acide nucléique à l'intérieur de celles-ci
Inventor: JOHNSTON CHRISTOPHER
IPC: C12N15/63
Filed: 2020-02-06
Abstract: Des modes de réalisation comprennent une bactérie productrice de minicercle génétiquement modifiée ayant une capacité de méthylation différentielle, ainsi que des kits et des compositions comprenant la bactérie. L'invention concerne en outre des procédés d'utilisation de la bactérie pour produire de l'ADN minicercle méthylé de manière différentielle et pour améliorer l'efficacité de transformation d'ADN exogène dans des bactéries réfractaires.
Patent WO-2020167899-A1 (WO)
Inventor: GUMBO TAWANDA
IPC: G01N33/48
Filed: 2020-02-12
Abstract: The present disclosure relates to methods, devices, and systems for treating a patient with tuberculosis. In an aspect of the present disclosure, a method includes receiving patient data corresponding to a TB patient. The patient data is associated with sputum time-to-positivity (TTP) data associated with a time period. The method further includes identifying, based on the patient data, a kill rate of semidormant/persistent (Y s ) Mycobacterium tuberculosis. The method also includes determining a treatment response prediction result based on the kill rate and generating an output based on the treatment response prediction result.
Patent WO-2020168271-A1 (WO)
Title: Méthodes et compositions pour le traitement de la gastrite à mastocytes, de l'œsophagite à mastocytes, de l'entérite à mastocytes, de la duodénte à mastocytes et/ou de la gastroentérite à mastocytes
Inventor: YOUNGBLOOD BRADFORD ANDREW
IPC: A61K39/395
Filed: 2020-02-14
Abstract: La présente invention concerne des méthodes pour le traitement de la gastrite à mastocytes, de l'œsophagite à mastocytes, de la colite à mastocytes, de l'entérite à mastocytes, de la duodénite à mastocytes et/ou de la gastroentérite à mastocytes. En particulier, la présente invention concerne des méthodes pour le traitement de la gastrite à mastocytes, de l'œsophagite à mastocytes, de la colite à mastocytes, de l'entérite à mastocytes, de la duodénite à mastocytes et/ou de la gastroentérite à mastocytes par l'administration d'anticorps qui se lient au gène Siglec-8 humain ou de compositions comprenant lesdits anticorps. La présente invention concerne également des articles manufacturés ou des kits comprenant des anticorps qui se lient au gène Siglec-8 humain pour le traitement de la gastrite à mastocytes, de l'œsophagite à mastocytes, de la colite à mastocytes, de l'entérite à mastocytes, de la duodénite à mastocytes et/ou de la gastroentérite à mastocytes.
Patent WO-2020176509-A1 (WO)
Title: Apparatuses, systems and methods for doors of an autonomous delivery vehicle
Inventor: PRINCIPE CHIRSTOPHER
IPC: E05B47/02
Filed: 2020-02-25
Abstract: A retention assembly may comprise a motor assembly and a self-locking worm drive coupled thereto. A cam may be fixed to a worm gear of the worm drive. The retention assembly may further comprise an actuation shaft including a follower. The actuation shaft may be displaceable over a displacement range via rotation of the cam. The retention assembly may further comprise a securement member with a securement member follower, the securement member coupled to a portion of the actuator shaft. The retention assembly may further comprise a housing cam included as part of the retention assembly housing and against which the securement member follower may be biased. The securement member may be in an open state when the actuation shaft is in a first position. The securement member may swing outward to a retaining position as the actuation shaft is moved to a second position.
Patent WO-2020176745-A1 (WO)
Title: Sorting cell-type specific extracellular vesicles
Inventor: VUNJAK-NOVAKOVIC GORDANA
IPC: C12Q1/68
Filed: 2020-02-27
Abstract: Disclosed is a method for identifying cell-type specific EV markers comprising culturing induced pluripotent stem cells (iPSCs) to provide a culture of a first differentiated cell type; isolating extracellular vesicles (EV)s from the culture of the differentiated cell type; generating a microscopic RNA (miRNA) expression profile for the differentiated cell type by next-generation sequencing; and identifying specific miRNA markers associated with the differentiated cells. Also dislcosed are methods for in vitro testing for a disease condition comprising providing a biological sample; isolating extracellular vesicles from said sample by labeling the extracellular vesicles using fluorescence in situ hybridization, and sorting the labeled extracellular vesicles by high resolution flow cytometry; and determining the status of exosomes and/or an exosome-associated marker in the sample, wherein an abnormal status of exosomes and/or the exosome-associated marker in the sample indicates the presence of a disease condition.
Patent WO-2020176761-A1 (WO)
Title: Imidazolopyrazine compounds for ire1 inhibition
Inventor: KEENAN RICHARD
IPC: A61K31/4184
Filed: 2020-02-27
Abstract: The present invention provides novel imidazolopyridine compounds compounds, compositions and methods for treating or preventing an IRE1 α-related disease or disorder. In certain embodiments, the disease or disorder is selected from the group consisting of a neurodegenerative disease, a demyelinating disease, cancer, an eye disease, a fibrotic disease, and diabetes.
Patent WO-2020185499-A1 (WO)
Title: Food coating compositions and methods of making food coating compositions
Inventor: HAVERKOS STEPHEN M
IPC: A23L5/10
Filed: 2020-03-05
Abstract: Food coating compositions and their methods of making are disclosed herein. One method includes mixing a porous coating composition with at least one flavor composition, wherein at least a portion of the at least one flavor composition is absorbed into pores of the porous coating composition; heating an oil feedstock to a temperature greater than the melting point of the oil feedstock to form a liquid oil; mixing the liquid oil with the at least one flavor composition prior to, contemporaneous with, or after the at least one flavor composition is mixed with the porous coating composition to provide an oil-flavor-porous coating mixture; and cooling the oil-flavor-porous coating mixture to 25C or less to form a food coating composition, wherein the liquid oil solidifies as an exterior coating for the porous coating composition and the flavor composition absorbed within the pores of the porous coating composition.