baber/WOPTO huggingface dataset:
Patent DK-0759934-T3 (DK)
Inventor: MARTIN JEAN-PAUL
IPC: A61P25/18
Filed: 1995-05-17
Granted: 1999-08-02
Abstract: PCT No. PCT/FR95/00643 Sec. 371 Date Nov. 19, 1996 Sec. 102(e) Date Nov. 19, 1996 PCT Filed May 17, 1995 PCT Pub. No. WO95/32218 PCT Pub. Date Nov. 30, 1995The invention is directed to a compound of formula    <IMAGE>  (I)  in which R represents a hydroxyl, alkyloxy, phenylalkyloxy or -NH-CH2-COOH radical, R1 represents a hydrogen atom, an adamantylacetyl, adamantylcarbonyl, norbornylacetyl, norbornylphenoxycarbonyl, benzoyl, nicotinoyl, 4-phenylbenzoyl, 4-tert-butylbenzoyl or 2-pyrrolidinecarbonyl radical or a protective group for an amine functional group, R2 represents an Arg or Lys residue, R3 represents an Arg or Lys residue, R4 represents a Pro residue, m, n and p, which are the identical or different, represent a number equal to 0 or 1, R5 and R6 are identical and represent a hydroxyl or methoxy radical and R7 represents a hydrogen, chlorine, bromine or iodine atom or a nitro radical, or the compound wherein one or a number of peptide bonds between two amino acid residues are replaced by -CH2-NH bonds or the peptide bond between the R2 and R3 amino acid residues is replaced by a CH=CH bond, provided that when R1 is a hydrogen atom, then the sum of m+n+p is at least equal to 1. The invention is also directed to a pharmaceutical composition comprising the compound of formula I and the preparation of the compound.
Patent DK-0737228-T3 (DK)
Inventor: YARNELL LARRY
IPC: C08K3/00
Filed: 1995-10-31
Granted: 2002-09-23
Abstract: Elastomeric compositions for incorporation in articles subject to dynamic loading, comprising an ethylene-alpha-olefin elastomer which is reinforced with a metal salt of an  alpha - beta -unsaturated organic acid. This composition is cured using a free-radical promoting material. The invention includes articles subject to dynamic loading incorporating these elastomeric compositions, and belting, including power transmission and flat belting incorporating as their main belt body portions these elastomeric compositions.
Patent DK-0747481-T3 (DK)
Inventor: MIDDELDORP JAAP MICHIEL
IPC: G01N33/569
Filed: 1996-05-28
Granted: 2002-04-08
Abstract: The invention relates to peptides or fragments thereof which are immunochemically reactive with Epstein-Barr Virus (EBV) antibodies. New antibodies directed to said peptides or fragments thereof are also part of the invention. The invention also relates to a method for the detection of EBV or antibodies directed against EBV in a test fluid and also to an immunochemical reagent comprising a peptide, a fragment or a polypeptide according to the invention and a test kit to be used when applying the said detection methods. Detection of EBV in a test fluid or tissue specimen using antibodies, monoclonal and polyclonal, directed to the said peptide, which have the characteristics of detecting both native and denatured EBV-EA protein is also part of said invention. <IMAGE>
Patent DK-0822934-T3 (DK)
Inventor: DANILEWICZ JOHN CHRISTOPHER
IPC: A61K38/00
Filed: 1996-04-01
Granted: 2000-05-15
Abstract: PCT No. PCT/EP96/01459 Sec. 371 Date Oct. 9, 1997 Sec. 102(e) Date Oct. 9, 1997 PCT Filed Apr. 1, 1996 PCT Pub. No. WO96/33993 PCT Pub. Date Oct. 31, 1996This invention is directed to compounds of formula (I),    <IMAGE>  (I)  pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates of either entity, wherein Y is optionally monounsaturated C3-C5 alkylene optionally substituted with C1-C4 alkyl or methylene; R1 is H; C1-C4 alkyl optionally substituted with C1-C4 alkoxy, OH, NR5R6, CONR5R6, C3-C6 cycloalkyl or aryl; or C3-C6 alkenyl; R2 is H; C1-C4 alkyl optionally substituted with C1-C4 alkoxy, OH, NR5R6, CONR5R6, C3-C6 cycloalkyl or aryl; or CONR5R6; R3 and R4 are each independently selected from H; C1-C4 alkyl optionally substituted with NR5R6; C1-C4 alkoxy; halo; CONR5R6 and aryl; aryl is phenyl optionally substituted with one, two or three substituents independently selected from C1-C4 alkyl, C1-C4 alkoxy, OH, halo and CF3; R5 and R6 are each independently selected from H and C1-C4 alkyl; and m and n are each independently 1, 2 or 3; which are potent and selective thrombin inhibitors useful in the treatment of inter alia, deep vein thrombosis; reocclusion following thrombolytic therapy; chronic arterial obstruction; peripheral vascular disease; acute myocardial infarction; unstable angina; atrial fibrillation; thrombotic stroke; transient ischaemic attacks; restenosis and occlusion following angioplasty; or neurodegenerative disorders.
Patent DK-0882718-T3 (DK)
Inventor: OKU TERUO
IPC: A61P17/00
Filed: 1996-12-27
Granted: 2005-12-12
Abstract: Novel benzimidazole derivatives represented by the formula (I): <CHEM> wherein R3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceutically acceptable salts. Because of their blood sugar-depressing effect or PDE5 inhibitory effect, these compounds or salts thereof are useful as medicines for treating impaired glucose tolerance, diabetes, diabetic complications, syndrome of insulin resistance, hyperlipidemia, atherosclerosis, cardiovascular disorders, hyperglycemia, or hypertension; or stenocardia, hypertension, pulmonary hypertension, congestive heart failure, glomerulopathy, tubulointerstitial disorders, renal failure, atherosclerosis, angiostenosis, distal angiopathy, cerebral apoplexy, chronic reversible obstructions, allergic rhinitis, urticaria, glaucoma, diseases characterized by enteromotility disorders, impotence, diabetic complications, nephritis, cancerous cachexia, or restenosis after PTCA.
Patent DK-0932780-T3 (DK)
Inventor: MARX NORBERT
IPC: F16K3/20
Filed: 1997-02-28
Granted: 2001-11-19
Abstract: Single-plate slide, especially single-plate pipe bridge slide (10) with a slide-plate (16) and if necessary a pipe bridge (20), which is or are movable by means of an actuating device (18, 19) within this casing (11) in order to close or open a fluid passage (17) formed in a casing (11), the slide plate (16) or pipe bridge (20) having lateral seal surfaces which correspond with seal surfaces located on the casing side, especially annular seal surfaces (14, 15). At least one of the seal surfaces (14, 15) on the casing side forms part of a seal ring (23) located in the casing (11), which abuts with resilient pre-stressing on the facing seal surface of the slide plate (16) or pipe bridge (20).
Patent DK-1021413-T3 (DK)
Inventor: LEVIN JEREMY IAN
IPC: C07D401/12
Filed: 1998-04-14
Granted: 2003-10-06
Abstract: This invention provides, low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF- alpha  converting enzyme (TACE, tumor necrosis factor- alpha  converting enzyme) of formula (B) wherein (B) is (1), (2), or (3); P and Q are (4) or (5), provided that when P is (4), Q is (5), and vice versa; T, U, W, and X are each, independently, carbon or nitrogen, provided that when T or U is carbon, either may be optionally substituted with R<1>; Y is carbon, nitrogen, oxygen or sulfur, provided that at least one of T, U, W, X, and Y is not carbon, and further provided that no more than 2 of T, U, W, and X are nitrogen; (6) is a phenyl ring or is a heteroaryl ring of ring 5-6 atoms which may contain 0-2 heteroatoms selected from nitrogen, oxygen, and sulfur, in addition to any heteroatoms defined by W or X; wherein the phenyl or heteroaryl ring may be optionally mono-, di-, or tri- substituted with R<1>; Z is a phenyl, naphthyl, heteroaryl, or heteroaryl fused to phenyl, wherein the heteroaryl moiety contains of 5-6 ring atoms and 1-3 heteroatoms selected from nitrogen, oxygen, or sulfur; wherein the phenyl, naphthyl, heteroaryl, or phenyl fused heteroaryl moieties may be optionally mono-, di-, or tri-substituted with R<1>; R<1> is hydrogen, halogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cyclocalkyl of 3-6 carbon atoms, -(CH2)nZ, -OR<2>, -CN, -COR<2>, perfluoroalkyl of 1-4 carbon atoms, -CONR<2>R<3>, -S(O)xR<2>-OPO(OR<2>)OR<3>, -PO(OR<2>)R<3>, -OC(O)NR<2>R3, -COOR<2>, -CONR<2>R<3>, -SO3H, -NR<2>R<3>, -NR<2>COR<3>, -NR<2>COOR<3>, -SO2NR<2>R<3>, -NR<2>CONR<2>R<3>, -NR<2>C(=NR<3>)NR<2>R<3>, -SO2NHCOR<4>, -CONHSO2R<4>, -tetrazol-5-yl, -SO2NHCN, -SO2NHCONR<2>R<3>, or Z; V is a saturated or partially unsaturated heterocycloalkyl ring of 5-7 ring atoms having 1-3 heteroatoms selected from N, O, or S, which may be optionally mono-, or di-substituted with R<2>; R<2> and R<3> are each, independently, hydrogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms; perfluoroalkyl of 1-4 carbon atoms, Z or V; R<4> is alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms; perfluoroalkyl of 1-4 carbon atoms, Z or V; R<5> is hydrogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, Z, or V; n = 1-6; x = 0-2 or a pharmaceutically acceptable salt thereof.
Patent DK-1015586-T3 (DK)
Inventor: FONG SHERMAN
IPC: C12N5/10
Filed: 1998-09-14
Granted: 2006-07-03
Abstract: The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligand homologues NL2, NL3 and NL6 (FLS139), the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
Patent DK-1095275-T3 (DK)
Inventor: CHALMERS DEREK T
IPC: G01N33/566
Filed: 1999-07-30
Granted: 2009-09-28
Abstract: Disclosed herein are techniques for directly identifying candidate compounds as agonists, partial agonists and/or, most preferably, inverse agonists, to endogenous, constitutively activated orphan G protein-coupled receptors. Such directly identified compounds can be utilized, most preferably, in pharmaceutical compositions.
Patent DK-1140156-T3 (DK)
Inventor: MCMASTER RONALD P
IPC: A61K39/09
Filed: 1999-12-16
Granted: 2007-03-26
Abstract: The present invention relates to the removal of unbound polysaccharides from conjugated polysaccharide-protein vaccines using the method of ultrafiltration whereby the diafiltration solution contains saturating levels of ammonium sulfate.
Patent ES-2180478-T3 (ES)
Title: Instalacion con un tablero de mesa de operaciones colocado de forma desmontable sobre un pedestal.
Inventor: KREUZER FRIEDHELM
IPC: A61G13/00
Filed: 2000-02-10
Granted: 2003-02-16
Abstract: Instalación con un tablero de mesa de operaciones (2) colocado de forma desmontable sobre un pedestal (1) y una estación de anestesia (3) y una estación de examen (7) dispuesta a cierta distancia de la mesa de operaciones y que presenta un pedestal (8) para recoger la placa de mesa de operaciones (2), caracterizada porque comprende un carril de techo (10) que se extiende sobre la mesa de operaciones y la mesa de examen (7), un dispositivo de transporte (14) sujeto por el carril (10) y desplazable sobre el mismo, y un soporte de techo (5) que porta la estación de anestesia (3), está sujeto por el carril (10) y es desplazable sobre el mismo, presentando el dispositivo de transporte (14) y el soporte de techo (5) elementos de acoplamiento (19, 21) respectivos que actúan entre sí y que se pueden acoplar cuando el dispositivo de transporte (14) llega a una primera posición para recoger el tablero de mesa de operaciones (2).
Patent ES-2223370-T3 (ES)
Inventor: GRIMM RAINER DIPL-ING
IPC: B62D65/00
Filed: 2000-11-10
Granted: 2005-03-01
Abstract: An inner shell (4) is molded out of plastics foam to form an interior roof lining, is manufactured separately from a vehicle body, and has outer edges that are supported on the framework (6) of a vehicle body having a front cross rail and side rails (9). The upper layer (7) of an inner shell is fixed securely to a bodywork frame using the fixing screws (19) for the sun visors and the handholds (3). The inner shell is divided into two layers in the vicinity of the outer edges intended to be supported on the framework. The upper layer of the inner shell is supported on the framework while the lower layer (8) of the inner shell is bent down to line the framework. The lower layer is furnished with preassembled sun visors in the vicinity of the front cross rail and the preassembled handholds in the vicinity of the side rails. The sun visors and the handholds are pivoted on the bearing components (18) to be caught in the front cross rail and the side rails.
Patent ES-2216819-T3 (ES)
Title: Procedimiento para incorporar proteina de suero en queso.
Inventor: KENT CLINTON
IPC: A23C19/076
Filed: 2000-01-14
Granted: 2004-11-01
Abstract: Un proceso para fabricar un producto de queso estable, enriquecido con proteína de suero funcionalmente mejorada, que comprende las etapas de: (i) preparar una cuajada de queso característica de una variedad particular de queso; (ii)combinar la cuajada de queso con una composición de proteína de suero para formar una mezcla de proteína de suero-queso, seleccionándose la composición de proteína de suero a partir de concentrado de proteína de suero seco, concentrado de proteína de suero líquido, proteína de suero aislada, suero dulce líquido o seco, suero ácido líquido o seco, y sus mezclas, y añadiéndose en una proporción tal que los sólidos de proteína de suero contenidos están presentes en una proporción de al menos 2 por ciento en peso del peso total de la mezcla a como máximo 12 por ciento en peso del peso total de la mezcla; y (iii) homogeneizar la mezcla a una presión de 6.894, 76 KPa a 55.158, 08 KPa (1.000 a 8.000 libras por pulgada cuadrada) y tratar la mezcla a una temperatura de 79, 44 a 101, 67ºC (175 a 215ºF) durante 2 a 60 minutos para mejorar la funcionalidad de la proteína de suero y formar un producto de queso estable; en el que el producto de queso incorpora establemente la proteína de suero funcionalmente mejorada y es característica de una variedad particular de queso.
Patent ES-2203408-T3 (ES)
Title: Procedimiento e instalacion para la produccion de hidrogeno puro a partir de un gas que contiene helio.
Inventor: FUENTES FRANCOIS
IPC: C01B3/36
Filed: 2000-10-31
Granted: 2004-04-16
Abstract: Procedimiento para la producción de hidrógeno (30) de alta pureza, sensiblemente libre de helio, a partir de un gas de alimentación (10) que contiene esencialmente hidrocarburos, especialmente metano, e impurezas tales como helio, del tipo que comprende la conversión de los hidrocarburos, especialmente metano, en hidrógeno y en dióxido de carbono, en una unidad de conversión (2), y la purificación en una unidad de adsorción a presión modulada, o PSA (3), del hidrógeno contenido en la mezcla gaseosa resultante, caracterizado porque, antes de la conversión de los hidrocarburos, especialmente metano, el gas de alimentación (10) se trata en una unidad de separación por permeación (1) que produce un gas retenido (11) empobrecido en helio, que contiene esencialmente hidrocarburos, especialmente metano, y un gas permeado (12) enriquecido en helio, siendo entonces dicho gas retenido (11) tratado en dicha unidad (2) de conversión de los hidrocarburos, especialmente metano, produciendo una mezcla gaseosa (20), prácticamente libre de helio, que contiene hidrógeno.
Patent ES-2335080-T3 (ES)
Inventor: RAO GALLA CHANDRA
IPC: G01N33/566
Filed: 2000-01-27
Granted: 2010-03-22
Abstract: Disclosed is a method that improves the efficiency of reactions between specific binding pairs. By translating one member of the pair through a suspension of the second member, or across a surface to which the second member is immobilized, collision and binding frequencies are greatly increased. The resulting increased binding frequency allows for reduced incubation times and lower incubation temperatures. The enhanced collisions are advantageous for both molecular reactions, in which mixing is not always effective, and cellular reactions, in which the cells may be damaged by mixing.
Patent ES-2230065-T3 (ES)
Title: Mecanismo estable de impulsion/retraccion.
Inventor: BOUIX HERVE F
IPC: A45D40/00
Filed: 2000-02-02
Granted: 2005-05-01
Abstract: Una funda para un producto en barra (21) que comprende: una camisa interior (5) que tiene una pared (6) y dos guías longitudinales (7, 7¿) dentro de la pared (6), estando cada guía longitudinal (7, 7¿) dispuesta aproximadamente en forma circunferencial opuestas una a otra; una camisa exterior (10) ajustada alrededor de la camisa interior (5), de forma que pueda girar con respecto a la camisa interior (5), teniendo dicha camisa exterior (10) una pared interior (11), una pared exterior (12), y ranuras helicoidales (13, 14, 15, 16) a lo largo de la pared interior (11); y una copa soporte (20) ajustada en la camisa interior (5), comprendiendo dicha copa soporte (20): un armazón (22) que tiene una superficie interior (23) y una superficie exterior (24); un primer grupo de orejas (25, 25¿) y un segundo grupo de orejas (26, 26¿) situados en la superficie exterior (24); caracterizada porque están dispuestas cuatro ranuras helicoidales (13, 14, 15, 16) y desde cada grupo se extiende una oreja a través de la misma guía longitudinal para aplicarse en una de las cuatro ranuras helicoidales (13, 14, 15, 16) y en la que al menos una oreja (25) es pivotable y capaz de ocupar una primera posición abierta y una segunda posición cerrada, en la que la oreja (25) penetra en el producto en barra (21).
Patent ES-2255492-T3 (ES)
Title: Combinacion de una camara y un piston.
Inventor: VAN DER BLOM NICOLAAS
IPC: F04B33/00
Filed: 2000-04-25
Granted: 2006-07-01
Abstract: Una combinación de cámara y pistón que comprende una cámara alargada (70) que está delimitada por una pared interior de cámara (71, 73, 75) y que comprende un medio de pistón (76, 76¿, 163) en dicha cámara para que se pueda mover de manera estanca respecto a dicha cámara al menos entre una primera y segunda posiciones longitudinales de dicha cámara, teniendo dicha cámara secciones transversales de diferentes áreas transversales en la primera y segunda posiciones longitudinales de dicha cámara y diferentes áreas transversales al menos de manera sustancialmente continua en posiciones longitudinales intermedias entre la primera y segunda posiciones longitudinales de la misma, siendo el área transversal en la primera posición longitudinal superior al área transversal en la segunda posición longitudinal, estando diseñado dicho medio de pistón para adaptarse y para adaptar dicho medio de estanqueidad a dichas áreas transversales diferentes de dicha cámara durante los movimientos relativos de dicho medio de pistón de la primera posición longitudinal, a través de dichas posiciones longitudinales intermedias, a la segunda posición longitudinal de dicha cámara, en la que el medio de pistón (76, 76¿, 163) comprende: - una pluralidad de elementos de sujeción al menos sustancialmente rígidos (81, 82, 184) fijados de manera giratoria a un elemento común (6, 23, 45, 180), - dichos elementos de sujeción integrados en un medio deformable elásticamente (79), sujeto por dichos elementos de sujeción, para cerrar herméticamente contra la pared interior (71, 73, 75, 155, 156, 157, 158) de la cámara (70) pudiendo girar dichos elementos de sujeción entre 10º y 40º respecto al eje longitudinal (19) de la cámara (70).
Patent ES-2233377-T3 (ES)
Inventor: IVERSEN GERT
IPC: F16J15/32
Filed: 2000-06-07
Granted: 2005-06-16
Abstract: A sealing arrangement is defined between a first apparatus part (10) and a cylindrical surface (13) of a second apparatus part. The sealing arrangement includes an annular sealing member (14) having a radially outer peripheral surface and a radially inner peripheral surface for providing a sealing engagement with the cylindrical surface (13) and for defining with the cylindrical surface a first space (20) widening or diverging from the contact area (19) toward the low pressure area (L). A compression ring (15) surrounds the annular sealing member (14). The axial sectional view of at least part of the outer peripheral surface (22) of the annular sealing member (14) defines a convex contour in an axial direction toward the low pressure area (L), with the radius or radii of curvature being at least 0.4 times the length or width of the annular sealing member (14).
Patent ES-2310524-T3 (ES)
Inventor: SPICER DOUGLAS A
IPC: C12N15/09
Filed: 2000-10-06
Granted: 2009-01-16
Abstract: This invention provides methods for removing unincorporated dye-labeled molecules from a mixture that includes dye-labeled polynucleotides or other polymers and the unincorporated dye-labeled molecules. The methods involve adsorbing the unincorporated dye-labeled molecules into a plurality of particles that are made up of one or more porous hydrophobic materials that are encapsulated in a hydrophilic matrix.
Patent ES-2199907-T3 (ES)
Inventor: MEYER ERICH
IPC: B65B51/30
Filed: 2001-03-27
Granted: 2004-03-01
Abstract: A packaging foil is folded in longitudinal direction, the products (2) are placed in the foil hose at relative distances, the foil is welded in longitudinal direction, perforated in transverse direction between the products and folded in the areas between the products, the air is extracted or escapes through the perforations, the hose is welded in transverse direction, and cut. The appliance has a folding unit, a perforator, a transverse welding module (4) with two pairs of welding jaws (6) and a suction device, and a cutter device with two knives (8).
Patent ES-2246968-T3 (ES)
Inventor: ANDERSON JOHN ERLING
IPC: F27D99/00
Filed: 2001-08-01
Granted: 2006-03-01
Abstract: A lance which may be used to generate a longer coherent gas jet having inflowing and outflowing coolant fluid passages which are in flow communication and which straddle the flame envelope fluid passages, all of which are coaxial with the main passageway. <IMAGE>
Patent ES-2292538-T3 (ES)
Title: Casete para soportes.
Inventor: WALKER NEIL
IPC: E05G1/00
Filed: 2001-06-22
Granted: 2008-03-16
Abstract: Un casete de soportes (10) que incluye un sistema de pulverización de fluido para pulverizar los soportes localizados dentro del casete (10), incluyendo el casete una parte absorbente (40), caracterizado porque la parte absorbente (40) se localiza en el fondo del casete (10) por debajo de cualquier soporte (42) almacenado en el casete para absorber cualquier fluido no absorbido por los soportes (42).
Patent ES-2311007-T3 (ES)
Title: Particulas de textura enmascarada que contienen un ingrediente activo.
Inventor: PARIKH NARENDRA
IPC: A61K9/20
Filed: 2001-12-21
Granted: 2009-02-01
Abstract: Una partícula de textura enmascarada que comprende: a) un núcleo que contiene un ingrediente activo; b) una primera capa compuesta por un agente enmascarador del sabor que sustancialmente cubre el núcleo; y c) una segunda capa sobre la superficie de la primera capa, estando compuesta la segunda capa por: i) un polímero formador de película; y ii) un segundo agente anti-granulado seleccionado entre polietilenglicol, óxido de polietileno y mezclas de los mismos; en la que la proporción en peso del polímero formador de película a agente anti-granulado en la segunda capa está en el intervalo de 20:80 a 80:20.
Patent ES-2299468-T3 (ES)
Inventor: GALAND DAMIEN
IPC: H04L12/721
Filed: 2001-10-11
Granted: 2008-06-01
Abstract: Method to advise on the capacity of a node to process messages in a specific way. The node in question sends routing messages periodically to neighbouring nodes. There is a stage in which information relating to the process is inserted in the routing messages.