baber/WOPTO huggingface dataset:
Patent NZ-564326-A (NZ)
Title: Prodrugs of A2B adenosine receptor antagonists
Inventor: KOLTUN DMITRY
IPC: A61K31/522
Filed: 2006-06-14
Abstract: The disclosure relates to prodrugs of A2B adenosine receptor antagonists of formula (I), and to their use in treating mammals for various disease states, such as gastrointestinal disorders, immunological disorders, hypersensitivity disorders, neurological disorders, and cardiovascular diseases due to both cellular hyperproliferation and apoptosis. These compounds are particularly suitable for treating atherosclerosis, angiogenesis, diabetic retinopathy, cancer, chronic obstructive pulmonary disease, and asthma. The disclosure also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
Patent NZ-568974-A (NZ)
Title: Enteric-coated glucosinolates and beta-thioglucosidases
Inventor: WEST LESLIE GEORGE
IPC: A23L33/00
Filed: 2008-06-09
Abstract: Disclosed is a non-therapeutic method of converting glucosinolate to isothiocyanate in the small intestine comprising orally administering to a subject an enteric-coated chemoprotectant precursor composition, said method comprising: (1) enteric-coated beta-thioglucosidase particles; and (2) enteric-coated glucosinolate particles, wherein beta-thioglucosidase and glucosinolate are released from the enteric-coated beta-thioglucosidase particles and enteric-coated glucosinolate particles, respectively, in the small intestine where beta-thioglucosidase converts glucosinolate to isothiocyanate. Also disclosed is a non-therapeutic method of converting glucosinolate to isothiocyanate in the small intestine comprising orally administering to a subject an enteric-coated capsule containing a chemoprotectant precursor composition comprising: (1) beta-thioglucosidase particles; and (2) glucosinolate particles, wherein beta-thioglucosidase and glucosinolate are released from the beta-thioglucosidase particles and glucosinolate particles, respectively, in the small intestine where beta-thioglucosidase converts glucosinolate to isothiocyanate. Also disclosed is an enteric-coated chemoprotectant precursor composition comprising: (1) about 0.5 to about 50 weight percent of glucosinolate particles; (2) about 0.5 to about 50 weight percent of beta-thioglucosidase particles; and (3) about 1 to about 99 weight percent of a composition comprising a coating excipient and optionally a diluent, wherein the glucosinolate or beta-thioglucosidase particles is encapsulated with an enteric coating. Also disclosed is an enteric-coated capsule comprising a chemoprotectant precursor mixture, the chemoprotectant mixture comprising uncoated beta-thioglucosidase particles and uncoated glucosinolate particles in a ratio of about 1:100 to about 100:1, wherein the mixture is contained within an enteric-coated capsule.
Patent NZ-572381-A (NZ)
Title: Amine derivative having npy y5 receptor antagonist activity
Inventor: KOUYAMA NAOKI
IPC: A61K31/18
Filed: 2007-04-25
Abstract: Disclosed is an amine derivative of formula (I) where the variable X contains a cyclic group (such as an optionally substituted cycloalkylene) and the other variables are as disclosed in the description. The compounds are useful as NPY Y5 receptor antagonists. Also disclosed is a pharmaceutical composition containing a compound of formula (I) and intermediate compounds used in the preparation of compounds of formula (I). Further disclosed is the use of the compounds in the preparation of a medicament for the treatment of obesity or suppressing food intake.
Patent NZ-572417-A (NZ)
Title: Thiazolyl dihydro-indazoles
Inventor: STEURER STEFFEN
IPC: C07D513/04
Filed: 2007-03-30
Abstract: Disclosed are selected compounds for example N-[4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluorophenyl]-3-chloropropionamide and 2-chloroethyl [4-(7-acetylamino-3-pyridin-3-yl-4,5-dihydro-pyrazolo[4,3-g]benzothiazol-1-yl)-3-fluorophenyl]-carbamidate for treating cancer.
Patent NZ-577805-A (NZ)
Title: Genetic markers for risk management of cardiac arrhythmia
Inventor: HELGADOTTIR ANNA
IPC: G16B20/40
Filed: 2007-12-05
Abstract: Provided is a method of determining a susceptibility to cardiac arrhythmia or stroke in a human individual, the method comprising determining the presence or absence of at least one allele of at least one polymorphic marker in a nucleic acid sample from the individual, wherein the at least one polymorphic marker is selected from rs2200733 and rs10033464, and markers in linkage disequilibrium therewith, wherein linkage disequilibrium is characterized by values of r2 of greater than 0.1, and wherein determination of the presence or absence of the at least one allele is indicative of a susceptibility to cardiac arrhythmia or stroke in the individual.
Patent NZ-578582-A (NZ)
Title: Electrochemical process for the preparation of halo amines such as monochloroamine
Inventor: CHENG HUAI N
IPC: C25B9/19
Filed: 2008-01-24
Abstract: 578582 Disclosed is a process for preparing haloamine biocides (such as monochloroamine, monobromoamine and N-chloroethylenediamine) in an integrated apparatus comprising an undivided electrochemical cell and a mixing chamber, wherein the cell comprises an anode and a cathode located in the cell at a distance from each other sufficient to minimise degradation of the active halogen donor species, wherein a first conduit that acts as the mixing chamber is connected to the cell at a point proximate the anode, and wherein a second conduit having a first and second end is connected to the cell at the first end at a point proximate the cathode and to the first conduit at the second end; the process comprising the steps of: (a) charging the electrochemical cell with a solution comprising a halide salt; (b) electrochemically generating at least one active halogen donor species in the electrochemical cell at the anode, and electrochemically generating hydroxide in the electrochemical cell at the cathode at a temperature in the range of from about 0oC to about 25oC; (c) transferring a solution of the electrochemically generated hydroxide from the cathode through the second conduit to mix with a solution of the at least one active halogen donor species in the first conduit prior to mixing with an at least one amine-containing composition, where upon mixing with the solution of the hydroxide the pH of the solution of the at least one active halogen donor species is increased; and (d) combining the at least one active halogen donor species with at least one amine-containing composition in said mixing chamber; wherein the combining is achieved by: (i) transferring the at least one active halogen donor species as a stream via the first conduit after the transferring of step (c): and (ii) merging the stream of (i) with a stream of the at least one amine-containing composition; wherein at least a portion of the at least one active halogen donor species reacts with at least a portion of the at least one amine-containing composition to form the halo amine biocide; and wherein the yield of the resulting halo amine biocide is at least 80%; and wherein the at least one active halogen donor species comprises hypochlorite, hypochlorous acid, or any combination thereof.
Patent NZ-596498-A (NZ)
Title: Transdermal methods and systems for the delivery of anti-migraine compounds
Inventor: ANDERSON CARTER R
IPC: A61N1/30
Filed: 2007-04-12
Abstract: 596498 An integrated iontophoretic transdermal patch adapted for the delivery of therapeutic anti-migraine agents to a subject in need thereof, the iontophoretic transdermal patch comprising:(a) an iontophoretic transdermal patch containing an amount of an active anti-migraine agent in the form of a triptan compound or a salt thereof; integrated with (b) electronic components configured to provide two-stage patterned delivery sequence which includes an initial first stage delivery at a relatively high rate followed by a second stage delivery at a lower rate, said patch being further characterized by a power/area ratio wherein the average current density is less than 250 ?A/cm2.
Patent NZ-597542-A (NZ)
Title: Topical composition containing ibuprofen
Inventor: FOSSEL ERIC THOR
IPC: A61K9/06
Filed: 2009-06-24
Abstract: Patent No. 597542 Disclosed is a composition for topical delivery to the skin of a subject, the composition comprising: a nitric oxide donor selected from L-arginine or a derivative thereof; a hostile biophysical environment comprising an ionic salt; a stabilization polymer comprising xanthan gum; propylene glycol; a polysorbate surfactant comprising polysorbate 20; and ibuprofen and/or an ibuprofen salt.
Patent NZ-598325-A (NZ)
Title: Distributed computing with meters
Inventor: SHORT ZACHARY MERIWETHER
IPC: G01F15/00
Filed: 2012-02-21
Abstract: Disclosed is a utility meter (101) for performing distributed computing tasks. The utility meter (101) includes a processor operative to receive a data processing task and data. The processor can then determine whether the utility meter (101) is available to process the data in response to receiving the data processing task and the data. The data is processed in the utility meter (101) if it is determined that the utility meter (101) is available to process the data. The results of the data processing are then sent from the utility meter (101) to a server (102).
Patent NZ-604987-A (NZ)
Title: Closure for a container
Inventor: FRASER ANTHONY HENRY JOSEPH
IPC: B65D53/02
Filed: 2011-06-03
Abstract: Disclosed is a closure for a container ( 1 ) having a circular opening defining an axis (A), the closure being securable to the container so as to close said opening, the closure having an o-ring sealing member (5) mounted thereon so as to provide a seal with a sealing surface (IB) of the container, when the closure is secured to the container, the sealing surface extending around an upper surface or an internal surface of the container. The closure may comprise a bore feature (4) which, in use, extends through the opening into the interior of the container and the o-ring seal (5) may be provided on the bore feature. Various forms of closure are described, eg for closing a bottle neck and a wide-mouth closure. The closure may comprise an inner component (3) and an outer component (2), eg cap - on - collar closure, and the container preferably has no thread features on the exterior thereof so it is comfortable to drink from.
Patent NZ-612423-A (NZ)
Title: Absorbent article including containment flaps
Inventor: ROBERT LEE POPP
IPC: A61F13/47
Filed: 2013-06-24
Abstract: Sanitary towels, incontinence pads or napkins (diapers) 10 are provided with flanged upstanding leakage guards 44, 46 extending on either side of the crotch region and from the front of the pad to the rear of the pad. Longitudinal folds 310a, 312a in the pad for packaging are disclosed, the fold lines extending from the front of the pad to the back of the pad and being situated on the outside of the outermost leakage guard flanges 81,83 when the pad is in the unfolded and stretched condition.
Patent NZ-613705-A (NZ)
Title: Igniting an underground coal seam in an underground coal gasification process
Inventor: SHAIKH FAZAL UDDIN
IPC: E21B43/295
Filed: 2012-02-20
Abstract: An ignition apparatus (150) configured to ignite an underground coal seam (151) in situ is disclosed. One of the major challenges for UCG is to ignite the coal underground, particularly in a safe and cost effective manner. Several methods have been proposed and used. One such method involves dropping hot coal or lowering an electrical heat resistance device into a vertically extending ignition well directly into an intended combustion zone and then injecting oxygen into the combustion zone via the injection well so that combustion is autogenous. The ignition apparatus disclosed attempts to overcome some of these issues of cost and safety by supplying an ignition device in the fuel/oxidiser injection tool (155). The ignition apparatus (150) comprising an ignition system, a positioning system, a sensor (170) and a controller (165). The ignition system comprises ignition means and an ignition tool (155) for igniting the underground coal seam (151) from within the well channel (154) or well liner encasing the well channel (154). The positioning system comprises coiled tubing (156) connected to the ignition tool (155) and extendible through a well head (153) within the well channel (154) to position the ignition tool (155) at a desired location within the well channel (154). The positioning system further comprises a spool (157) for transporting and dispensing the coiled tubing (156).
Patent NZ-616786-A (NZ)
Title: Top-loadable freight vehicle
Inventor: BROWN GREGORY ALAN
IPC: B60P1/00
Filed: 2013-10-17
Abstract: Disclosed is a top loadable freight vehicle or truck that includes a chassis having ground or track engaging wheels, a floor over the chassis for supporting freight, front and rear end wall structures and opposed side wall structures. The wall structures, with the floor, define an enclosure for the freight. The vehicle further includes at least one location intermediate of the end walls at which there is a crossbeam member adjustably secured at a first end to the top of a first one of the side wall structures and movable between an engaged position in which its second end is releasably engaged with the top of a second one of the side wall structures, and a disengaged position enabling top loading of the vehicle.
Patent NZ-617198-A (NZ)
Title: Sustained release paracetamol formulations
Inventor: BUAN CARLA VALENTI
IPC: A61K31/167
Filed: 2012-05-04
Abstract: The present disclosure is directed to twice daily sustained release pharmaceutical composition of paracetamol having an immediate release phase of paracetamol and a sustained release phase of paracetamol, said composition having unique and advantageous pharmacokinetic properties and a pharmaceutical composition comprising only a sustained release phase of paracetamol having unique and advantageous pharmacokinetic properties. The formulations are useful for the treatment of analgesia or pain. The formulation preferably contains 2000mg paracetamol administered in two tablets, each tablet having 1000mg of paracetamol present in a sustained release phase and an immediate release phase, in which the ratio of the paracetamol in the sustained release phase to the immediate release phase is about 80-90% to 10-20%, and wherein the sustained release phase comprises from 0.5% to 3% w/w of a pre-gelatinized starch and a matrix forming polymer of hydroxypropylmethyl cellulose, wherein the hydroxypropylmethyl cellulose contains a high viscosity hydroxypropylmethyl cellulose having a viscosity between 3500 and 6000 centipoise, and a low viscosity hydroxypropylmethyl cellulose having a viscosity between 10 and 30 centipoise, wherein, said high viscosity hydroxypropylmethyl cellulose and said low viscosity hydroxypropylmethyl cellulose are respectively present in an amount from 4% to 6% by weight, and from 1% to 2% by weight of the sustained release phase.
Patent NZ-714390-A (NZ)
Title: A rotor blade of an aerodynamic rotor of a wind turbine
Inventor: ALTMIKUS ANDREE
IPC: F03D1/06
Filed: 2014-06-11
Abstract: The present invention seeks to improve the aerodynamic properties of a rotor blade of a wind turbine for weak wind sites. To improve the aerodynamic properties, the present invention provides a rotor blade of an aerodynamic rotor of a wind turbine, comprising: at least a first and a second wing fence (810, 820), wherein the first wing fence (810) is arranged at the rotor blade in radial direction in relation to an axis of rotation of the rotor, in a range of 25% to 40% of radial length, and the second wing fence (820) is arranged at the rotor blade in radial direction in relation to the axis of rotation of the rotor, in a range of 45% to 60% of radial length; characterized in that the rotor blade has a blade nose (803) and a rear edge (804) facing away from the blade nose (803) and that each wing fence (810, 820) or fence section (811, 812, 821, 822), respectively, increases in terms of its height (h) starting from the blade nose (803) all the way to the rear edge (804), in particular, that it starts at a height (h) of 0 to 5 mm close to the blade nose (803) to then continuously increase up to a height (h) of more than 15 mm all the way to the rear edge (804).
Patent NZ-717925-A (NZ)
Title: Fastener driving tool with an automatic nose chamber guide member
Inventor: SEGURA RICARDO
IPC: B25C5/16
Filed: 2014-08-21
Abstract: A fastener driving tool (12) with an improved nose chamber guide member (12) is provided for driving fasteners (14) of at least two different lengths. Multiple fasteners in a magazine are guided toward a driving bore (20) to be driven by a driver blade (22). A nosepiece (24) defines a passageway of the fasteners (14). The guide member (12) is operatively connected to the nosepiece (24) and is configured for transitioning between a first position and a second position relative to the nosepiece (24) in a direction (40) transverse to an operational flow direction of the fasteners (14). In the first position, the guide member (12) is disposed to align with the driving bore (20) for allowing driving of the fasteners (14) having a first length. In the second position, the guide member (12) is disposed out of alignment with respect to the driving bore (20) for allowing driving of the fasteners (14) having a second length, which is longer than the first length.
Patent NZ-727493-A (NZ)
Title: Methylated markers for colorectal cancer
Inventor: PEDERSEN SUSANNE
IPC: C12Q1/68
Filed: 2015-06-03
Abstract: Disclosed herein is a combination of genomic sequences whose methylation patterns have utility for the improved detection and differentiation between colorectal neoplasms. The method involves detecting the methylation state of the Septin 9 gene and at least one of IKZF1 and BCAT1. Further disclosed herein are methods, nucleic acids and kits for detecting or differentiating between colorectal neoplasms.
Patent NZ-728320-A (NZ)
Title: Automatic dispensing device for wallboard joint taping
Inventor: NEGRI ROBERT H
IPC: E04F21/165
Filed: 2015-06-19
Abstract: An automatic dispensing device (10) for wallboard joint taping is provided, including a body (12) for holding a supply of viscous material and having a rear end (16) and an opposite front end (18), a spool assembly disposed on the body and configured for supporting a spool (20) of tape; at least one drive roller (34) positioned at the front end and receiving an end of the spool of tape. There is an adhesive application assembly connected to the drive roller and mounted in operational relationship to the front end for dispensing a measured amount of adhesive upon an upper surface of the tape upon rotation of the at least one drive roll, and an an idler gear disposed at the front end of the body and separated from the driver roller and the adhesive application assembly. The driver roller and the cable drum each being independently connected to the idler gear. The device reduces the use of adhesive.
Patent NZ-750145-A (NZ)
Title: Separating polymer from composite structures
Inventor: COLLINS DENNIS MARTIN
IPC: C08J11/08
Filed: 2017-08-24
Abstract: The present invention provides a method of promoting separation of polymer bonded to a substrate of different material, which collectively form at least part of a polymer composite structure, the method comprising: (1) contacting the polymer composite structure with a composition comprising organic solvent which is absorbed within one or both of the polymer and substrate, wherein the composition comprising organic solvent does not dissolve either the polymer or the substrate, and (2) contacting the polymer composite structure provided in step (1) with liquid (i) having a temperature higher than the boiling point of the composition comprising organic solvent used in step (1), and (ii) that does not dissolve either the polymer or the substrate, the action of which promotes separation between the polymer and the substrate.
Patent NZ-753051-A (NZ)
Title: Liver organoid compositions and methods of making and using same
Inventor: TAKEBE TAKANORI
IPC: C12N5/00
Filed: 2017-11-03
Abstract: Disclosed are methods of inducing formation of a liver organoid from precursor cells, such as iPSC cells. The disclosed liver organoids may be used for screening for a serious adverse event (SAE), such as liver failure and/or drug induced liver injury (DILI), and/or drug toxicity. The disclosed liver organoids may also be used to treat an individual having liver damage, or for identifying a preferred therapeutic agent. A particular embodiment of the invention is a method of inducing formation of a liver organoid, comprising the steps of a) contacting definitive endoderm (DE) with an FGF pathway activator and a GSK3 inhibitor for a first period of time sufficient to form posterior foregut spheroids, wherein the first period of time is from about 1 day to about 3 days; b) incubating said posterior foregut spheroids of step a) in the presence of retinoic acid (RA) for a second period of time sufficient to form said liver organoid, wherein the second period of time is from about 1 day to about 5 days; and c) incubating said liver organoid of step b) with hepatocyte culture medium (HCM) comprising hepatocyte growth factor, dexamethasone and Oncostatin M for a third period of time sufficient to mature said liver organoid, wherein the third period of time is about 10 days to about 15 days, and wherein the liver organoid is characterized by albumin secretion and comprises a luminal structure comprising internalized microvilli comprising mesenchymal cells, wherein said luminal structure is surrounded by polarized hepatocytes and basement membrane.
Patent NZ-787969-A (NZ)
Title: Blast cell cooling with guided airflow
Inventor: ZHANG ALEXANDER MING
IPC: F25D17/08
Filed: 2020-06-26
Abstract: An apparatus for cooling items, the apparatus comprising: a housing (102) defining a bay space (112) and including a plurality of rows (114 A-C) in the bay space, each of the plurality of rows configured to hold one or more pallets (92) of items to be cooled; at least one fan (130) arranged away from the bay space and configured to circulate air through the bay space in the housing, the at least one fan operable to pull the air from a rearward region (140) of the bay space and discharge the air toward an opposite forward region of the bay space; a plurality of channels (141) arranged between the rearward region of the bay space and the at least one fan, each defining a fluid pathway from a corresponding row of the plurality of rows to the at least one fan and configured to direct air flow between the rearward region of the bay space and the at least one fan through the fluid pathway; and a controller (170) configured to selectively operate the at least one fan in a plurality of modes including a first operational mode and a second operational mode, wherein the at least one fan is configured to create air flow in a first direction in the first operational mode and in a second direction, which is opposite to the first direction, in the second operational mode, the controller configured to perform operations comprising: receiving a schedule for a cooling cycle; receiving operational factors; determining a first trigger condition based on at least one of the schedule and the operational factors; and switching, based on the first trigger condition, the at least one fan from the first operational mode to the second operational mode. The invention provides a means for regulating the temperature of goods in a blast freezer or cold storage facility through the controlled operation of a reversible flow circulating fan based on trigger conditions derived from an operational schedule and/or environmental parameters.