Patent SG-11201900400Q-A (SG)
Title: Bispecific antibody-like binding proteins specifically binding to cd3 and cd123
Inventor: ALBRECHT JANA
IPC: C07K16/28
Filed: 2017-07-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1#11101111 0 11101 HOE 3E1 0 01111113 10111001110110111011011# International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/015340 Al 25 January 2018 (25.01.2018) WIP0 I PCT (51) International Patent Classification: C07K 16/28 (2006.01) A61K 39/00 (2006.01) FRANKFURT AM MAIN (DE). KROLL, Katja; c/ o sanofi-aventis Deutschland GmbH, 65926 FRANK- A61K 39/395 (2006.01) FURT AM MAIN (DE). LANGE, Christian; c/o sanofi- (21) International Application Number: aventis Deutschland GmbH, 65926 FRANKFURT AM MAIN (DE). LEUSCHNER, Wulf Dirk; c/o sanofi-aven- PCT/EP2017/068020 tis Deutschland GmbH, 65926 FRANKFURT AM MAIN (22) International Filing Date: (DE). RAO, Ercole; c/o sanofi-aventis Deutschland GmbH, 17 July 2017 (17.07.2017) 65926 FRANKFURT AM MAIN (DE). SCHNEIDER, Marion; c/o sanofi-aventis Deutschland GmbH, 65926 (25) Filing Language: English FRANKFURT AM MAIN (DE). WONEROW, Peter; c/ (26) Publication Language: English o sanofi-aventis Deutschland GmbH, 65926 FRANKFURT (30) Priority Data: AM MAIN (DE). GUERIF, Stephane; c/o Sanofi, Patent 16305923.1 18 July 2016 (18.07.2016) EP Department, 54 me la Boetie, 75008 Paris (FR). (74) Agent: TINEL, Marie-Line; c/o Sanofi, Patent Depart- (71) Applicant: SANOFI [FR/FR]; 54 me La Boetie, 75008 PARIS (FR). ment, 54 me La Boetie, 75008 PARIS (FR). (81) Designated States (unless otherwise indicated, for every (72) Inventors: ALBRECHT, Jana; c/o sanofi-aventis kind of national protection available): AE, AG, AL, AM, Deutschland GmbH, 65926 FRANKFURT AM MAIN AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (DE). BEIL, Christian; c/o sanofi-aventis Deutschland CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, — GmbH, 65926 FRANKFURT AM MAIN (DE). BENIN- DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, GA, Jochen; c/o sanofi-aventis Deutschland GmbH, 65926 HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = Title: BISPECIFIC ANTIBODY-LIKE BINDING PROTEINS SPECIFICALLY BINDING TO CD3 AND CD123 (54) = = A B = r1 I g2 , 3i = KD .azr IVO = _ 245 i = 190 kl 135 100 ,„,, w 1 = 80 *ft Mil — = '4' = 58 2,1,0 1 46 ,.„„ . 32 . at I i wen = = _ = 25 lis i . Ate toT 22 ..., 17 .... R iu 11 .-44 — ,—, FIG.2 © 7r M 11 in (57) : The present invention concerns antibody-like binding protein specifically binding to CD3 and CD123. The invention also C ,—, - --- GC relates to pharmaceutical compositions comprising said antibody-like binding protein and the use of said pharmaceutical compositions , 1 and antibody-like binding protein to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising 0 a sequence encoding said antibody-like binding protein. ei C [Continued on next page] WO 2018/015340 Al MIDEDIMOMOIDEIREIDIONIM11011100H0110EVOIS KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))