baber/WOPTO huggingface dataset:
Patent ES-2279849-T3 (ES)
Inventor: CRAMERI RETO PROF DR
IPC: C07K14/38
Filed: 2002-10-11
Granted: 2007-09-01
Abstract: A modular antigen-transporting molecule (MAT) comprising one each of a translocation module (TrM), a targeting module (TaM) and an antigen module (AM), is new.  Modular antigen-transporting molecule (MAT) comprising at least one each of translocation module (TrM), targeting module (TaM) and antigen module (AM) is new. TrM is able to transport MAT from the extracellular space into a cell; TaM directs transport of MAT to organelles involved in processing of antigens (Ag) or loading of MHC (major histocompatibility complex) molecules, and AM determines the specificity of the immune response induced by MAT.  Independent claims are also included for the following: (1) method for preparing MAT;  (2) nucleic acid (I) that encodes MAT;  (3) vector containing (I) and preferably at least one of promoter, antibiotic or antimycotic resistance gene;  (4) primary cells or cell lines containing a vector of (3) or (I);  (5) vesicles, especially exosomes, deoxosomes or liposomes that contain at least one MAT, (I) or the vector of (3);  (6) immunoglobulins (Ig), or their fragments, that recognize MAT, prepared by immunization of a human or animal;  (7) method for identifying substances that inhibit or stimulate presentation of Ag through the MHC;  (8) method for identifying specific epitopes of Ag;  (9) in vitro cultured cells, human or animal, that have been treated with MAT, (I), the vector of (3) or vesicle of (5) and show modulated Ag presentation; and  (10) method for preparing antibodies (Ab), using MAT, (I), vesicles of (5), or cells of (4) or (9), by immunization.
Patent ES-2278869-T3 (ES)
Inventor: CHEN CHII-SHU
IPC: C08F299/04
Filed: 2002-07-29
Granted: 2007-08-16
Abstract: Use of OO-t-amyl-O(2-ethylhexyl)monoperoxycarbonate as a curing catalyst for bulk molding compounds ("BMC"s) and sheet molding compounds ("SMC"s) is provided.
Patent ES-2242848-T3 (ES)
Inventor: D URBINO DONATO
IPC: A47B1/04
Filed: 2002-01-03
Granted: 2005-11-16
Abstract: A table (10) is angularly mobile on an vertical rotation axis (X-X) with respect to a fixed base (1, 3); an articulated rod 16) forming a strut is articulated by means of end ball joints (18, 20) both under the flap (12) and to a support (14) of the base (1,3) at a distance from the axis (X-X) of angular mobility of the table; the flap is raised when the table is turned in one direction and the same flap is lowered when the table is turned in the opposite direction.
Patent ES-2274012-T3 (ES)
IPC: E04G5/06
Filed: 2002-02-19
Granted: 2007-05-16
Abstract: The connecting structure includes sheet steel corner plates (20) at the connecting area between the cross brackets (14) and frame struts (12). The corner plates have corner recesses (22) through which a coupling unit is connected and level with these corner recesses inwardly off-set is a further recess (24). A further coupling unit with coupling elements is provided so that a frame tube can be connected to the first coupling element and the second coupling element is formed so that it can be fixed with keyed and /or force locking engagement in the further recess of the corner plate. Independent claim describes coupling unit having first and second coupling elements.
Patent ES-2309180-T3 (ES)
Inventor: EASON STEPHEN WILLIAM
IPC: A61M1/36
Filed: 2002-05-10
Granted: 2008-12-16
Abstract: An inhaler for producing an inhalable aerosol of a powdered medicament includes an aerosolising device in the form of a vortex chamber 1. The vortex chamber 1 has a curved wall 12, a tangential inlet port 3 and an axial exit port 2. The radius R of the vortex chamber 1 decreases with angular extent   r   from the inlet port 3. The vortex chamber 1 may include a ramp 20 which reduces the height of the chamber with angular extent   r  . The reduction in effective cross-sectional area of the vortex chamber accelerates the gas flow between the inlet 3 and the outlet 2 to reduce deposition of the medicament.
Patent ES-2283580-T3 (ES)
Inventor: MILBRATH DEAN S
IPC: C10N40/22
Filed: 2002-07-26
Granted: 2007-11-01
Abstract: The present invention provides a composition for cutting or abrasive working operations that comprises at least one lubricious additive and at least one hydrofluorocarbons. The present invention also provides a method for cutting or abrasive working.
Patent ES-2239246-T3 (ES)
Inventor: JAKOBSEN BENT KARSTEN
IPC: A61K48/00
Filed: 2002-08-30
Granted: 2005-09-16
Abstract: The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR α chain, except the transmembrane domain thereof, and (ii) all or part of a TCR β chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR.
Patent ES-2325916-T3 (ES)
Title: Actividad antiangiogenica de analogos de talidomida sustituidos con nitrogeno.
Inventor: SHAH JAMSHED H
IPC: A61P9/00
Filed: 2002-08-06
Granted: 2009-09-24
Abstract: Uso de un compuesto en la fabricación de un medicamento para el tratamiento de la angiogénesis no deseada en un ser humano ó animal, en el que el compuesto se selecciona de los compuestos siguientes: ** ver fórmula** o combinaciones de los mismos, en las que: R1 se selecciona independientemente de -H, -OH, -CH3, -CH2OZ, -CH2OCOZ, -CH2=CONZ2, ó -CH2Z, en las que Z se selecciona de H ó -(CH 2) n-H, en la que n es 1-10; R2 se selecciona independientemente de -NH-NH2, -NH-OH, -NH-OR3, -N=N-R3, -NHCOH3, -NHCOCH3, pirazolidina, pirazolina, tetrazol, imidazol, pirazol, piperacina, ó imidazolina; y R 3 se selecciona independientemente de pirazolidina, pirazolina, tetrazol, imidazol, pirazol, piperazina, ó imidazolina.
Patent ES-2300474-T3 (ES)
Inventor: SIEVERDING ALFONS
IPC: A01G9/02
Filed: 2002-08-28
Granted: 2008-06-16
Abstract: A stackable deep-drawn plastic container has an at least slightly conical wall and a bottom connected to the conical wall. The wall has a rim area remote from the bottom. The rim area has a first ledge and a second ledge located below the first ledge. It also has an intermediate support area having a first end connected to the first ledge and a second end connected to the second ledge. A stacking spacing of the deep-drawn plastic container when stacked in a stack is determined by the first and second ledges. The first and second ledges in a plan view onto the rim area overlap at least partially. The intermediate support area has a first width at the first ledge that is smaller than a width at the second ledge. The intermediate support area has a wave shape at least at one of the first and second ends.
Patent ES-2261731-T3 (ES)
Inventor: DAHLMANN UWE
IPC: C23F11/173
Filed: 2002-04-30
Granted: 2006-11-16
Abstract: The present invention relates to compounds of formula (1) and the salts thereof which correspond to formula (2). In the formulae, A is C<SUB>2</SUB>- to C<SUB>4</SUB>-alkylene, x is a number from 1 to 100, y is a number from 1 to 4, and R is a cation. The compound of formula (1) and/or formula (2) forms a persistent film on metal surfaces, particularly on metal surfaces under stress in metal working and in the operation of crude oil and natural gas processing.
Patent ES-2303553-T3 (ES)
Inventor: MERISKO-LIVERSIDGE ELAINE
IPC: A61P31/04
Filed: 2002-09-13
Granted: 2008-08-16
Abstract: Methods for stabilizing active agents, particularly pharmaceutical agents, are described. The method comprises forming active agents into a nanoparticulate composition comprising the active agent and at least one surface stabilizer. The component active agent exhibits chemical stability, even following exposure to, for example, a prolonged storage period, an elevated temperature, light, radiation, radiation causing photolysis, non-physiological pH, enzymes or other catalysts, water or other solvent molecules, oxidizing agents or other free radicals, or freezing.
Patent ES-2362495-T3 (ES)
Inventor: SINGH KRISHNA PAL
IPC: G21F9/36
Filed: 2003-12-12
Granted: 2011-07-06
Abstract: The present invention provides a method and system for ensuring that cavities used to store radioactive elements are adequately dried without intrusive measuring. In one aspect the invention is a method of drying a cavity loaded with radioactive elements, the loaded cavity having a free volume ( V F  ), a starting vapor pressure ( vP s  ), and a cavity pressure ( P C  ), the method comprising: determining a desired degree of dryness in the cavity in terms of a desired vapor pressure ( vP D  ); cooling a non-reactive gas to a temperature ( T C  ) thereby drying the non-reactive gas; introducing the dry non-reactive gas into the cavity so that the free volume  V F   of the cavity turns over  X  times; and removing wet non-reactive gas from the cavity; wherein  T C   and  X  are controlled to achieve the desired vapor pressure ( vP D  ) in the cavity. Alternatively, a flow rate ( R ) can be controlled over time ( t ) instead of controlling  X.
Patent ES-2298472-T3 (ES)
Inventor: IHDE STEFAN DR
IPC: A61C8/00
Filed: 2003-02-10
Granted: 2008-05-16
Abstract: The basic part (2) to be accommodated in the bone cavity is rectangular shaped with one semi-circular end (7) and is designed as a frame with one or two transversal bridges (4,5,6) in order to offer stability but also to facilitate a certain level of motion. The vertical part (3) is screwed to a slightly elevated area (H1) located at the horizontal part (2) and is provided with an axial recess (18) in the center. The anchoring component (2) is preferably made of Delrin(RTM), the vertical part (3) is made of titan, the level of rigidity adjusted to the position of the implant in order to partly give in to or to counteract the forces acting on the artificial tooth.
Patent ES-2271524-T3 (ES)
Title: Activacion termica de peliculas.
Inventor: KREBS MICHAEL
IPC: C08J5/12
Filed: 2003-01-07
Granted: 2007-04-16
Abstract: Procedimiento de revestimiento de películas superficiales mono- o multicapa a base de polímeros con una temperatura de transición vítrea superior a 50°C sobre artículos moldeados de cloruro de polivinilo (FVC), polipropileno, copolímeros acrilonitrilo- butadieno-estirol (ABS), madera o aluminio caracterizado por los siguientes pasos procedimentales esenciales: a) cuando resulte apropiado, pretratamiento de la superficie de la película con un limpiador, b) cuando resulte apropiado, seguido de un tratamiento corona, c) cuando resulte apropiado, seguido de la aplicación de una imprimación sobre la superficie de la película, e) aplicación de un adhesivo reactivo de fusión de poliuretano sobre la superficie de la película, f) cuando resulte apropiado, pretratamiento de las superficies de los artículos moldeados mediante aplicación de imprimación o tratamiento con un limpiador, cuando resulte apropiado, seguido de evaporación de los componentes volátiles cuando resulte apropiado, con suministro de calor, cuando resulte apropiado, seguido de un tratamiento corona o tratamiento a la llama de la superficie del artículo moldeado, g) montaje de la película sobre los artículos moldeados, cuando resulte apropiado, con presionado, llevándose a cabo una activación térmica de la película, o bien como d) activación térmica mediante calentamiento con radiación electromagnética, antes de la aplicación del adhesivo de fusión y/o como h) activación térmica mediante radiación por convección o radiación IR de onda larga o con radiación electromagnética tras el montaje de la película y el artículo moldeado.
Patent ES-2256722-T3 (ES)
Inventor: BECKERT THOMAS
IPC: A61K47/42
Filed: 2003-03-06
Granted: 2006-07-16
Abstract: The invention relates to a pharmaceutical formulation containing essentially a) an inner layer which can optionally be applied to a core, with the active substance budesonide, bound with a binding agent; b) a middle layer with a polymer covering agent which is soluble in intestinal juice or retardant; and c) an outer envelope or outer layer which is resistant to stomach juice, said layers being able to contain in a manner known per se other pharmaceutically usual adjutants. The inventive formulation is characterised in that the binding agent is a polymer or a copolymer with acid groups and the formulation of the inner layer without the middle and outer layer releases the bound active ingredient in a release test according to USP XXIII monography <711> dissolution with apparatus 2 (addle) at a rotational speed of 100/min in a phosphate buffer pH 7.5 after 30 min to a value of more than 80%.
Patent ES-2537171-T3 (ES)
Title: Micro-raspador con características de raspado controladas
Inventor: LASTOVICH ALEXANDER
IPC: A61M37/00
Filed: 2003-08-27
Granted: 2015-06-03
Abstract: Un dispositivo (2) raspador para suministrar una sustancia a la piel mediante un procedimiento de raspado, en el que dicho dispositivo raspador comprende: una base (4) que tiene una superficie superior y una superficie inferior sobre la que está montada una superficie (5) de raspado con micro-protuberancias (14), en el que dichas micro-protuberancias tienen al menos un borde de raspado para formar un surco a lo largo de una longitud de la piel; un asa (6) que sobresale desde la superficie superior de la base; y medios para controlar la cantidad de fuerza o presión aplicada a las micro-protuberancias conforme la superficie del raspador se mueve a través de la piel formando de esta manera un surco de una profundidad sustancialmente coherente a lo largo de su longitud caracterizado por que dichos medios para controlar la cantidad de fuerza o presión son un muelle (46) pre-cargado que se desvía solo si hay presente una cantidad suficiente de presión.
Patent ES-2297204-T3 (ES)
Title: Compuestos pirrolicos recocidos como inhibidores de la bomba de protones para el tratamiento de la ulcera.
Inventor: SMOLKA ADAMS J
IPC: C07D/
Filed: 2003-05-16
Granted: 2008-05-01
Abstract: Utilización de ácido [6-(4-clorofenil)-2, 2-dimetil-7-fenil-2, 3-dihidro-1H-pirrolizin-5-il]acético de fórmula (Ia): (Ia) de una sal fisiológicamente aceptable del mismo o de un éster fisiológicamente hidrolizable del mismo para preparar una composición farmacéutica para tratar una lesión de la mucosa gástrica.
Patent ES-2388918-T3 (ES)
Title: Procedimientos que utilizan membranas de permeabilidad selectiva de sólidos en múltiples grupos para la recuperación simultánea de productos específicos a partir de una mezcla de fluidos
Inventor: COLLING CRAIG
IPC: C01B3/50
Filed: 2003-06-26
Granted: 2012-10-19
Abstract: Procedimiento que utiliza membranas selectivamente permeables en múltiples grupos para la recuperaciónsimultánea de un producto filtrado y un producto no filtrado deseado a partir de una mezcla fluida de compuestos,cuyo procedimiento comprende:(a) proporcionar una corriente de alimentación que comprende una mezcla de un compuesto alcano quetiene de 2 a 4 átomos de carbono y un compuesto alqueno que tiene el mismo número de átomos de carbonocomo componente predominante de la corriente de alimentación,(b) proporcionar un equipo que comprende una pluralidad de módulos de membrana incluyendo cada unouna primera y una segunda zona separadas por una membrana sólida de permeabilidad selectiva que bajo undiferencial determinado de fuerza motriz, que es predominantemente una diferencia de presión parcial entre lasdos caras de la membrana, muestra una permeabilidad de por lo menos 0,1 Barrer para uno de dichoscompuestos alcano y alqueno de la materia prima, teniendo cada primera zona por lo menos una entrada y unasalida para el flujo del fluido en contacto con la membrana y, contiguo con el lado opuesto de la misma, unasegunda zona que tiene por lo menos una salida para el flujo del filtrado y los módulos de membrana del equipoestán dispuestos en un primer grupo de productos, un segundo grupo de productos y por lo menos un grupointermedio, cuyo grupo intermedio tiene membranas con una selectividad superior para dichos compuestosalcano y alqueno de la materia prima que la de las membranas en por lo menos uno de los otros grupos,(c) introducir la corriente de alimentación en la primera zona de uno o más de los módulos intermedios bajocondiciones adecuadas para la filtración y así obtener efluentes filtrados y corrientes no filtradas de los módulosintermedios,(d) distribuir las corrientes no filtradas de los módulos intermedios en la primera zona de uno o más de losmódulos del segundo producto bajo condiciones adecuadas para la filtración,(e) recoger los efluentes filtrados de las segundas zonas del grupo intermedio de los módulos y distribuir losfiltrados en las primeras zonas de los módulos del primer grupo de producto bajo condiciones adecuadas para lafiltración, de manera que se obtienen corrientes de no filtrado y corrientes de producto filtrado final de losmódulos del primer producto, y(f) distribuir las corrientes de no filtrado de los módulos del primer producto a la primera zona de uno o másde los módulos intermedios bajo condiciones adecuadas para la filtración, y(g) recoger los efluentes filtrados de las segundas zonas de los módulos del segundo producto y distribuir elfiltrado en las primeras zonas de los módulos del primer grupo de producto.
Patent ES-2298582-T3 (ES)
Inventor: FRANKS NICHOLAS P
IPC: A61K9/08
Filed: 2003-08-05
Granted: 2008-05-16
Abstract: In a first aspect, the present invention relates to the use of xenon in the preparation of a medicament for providing analgesia in a newborn subject and/or a fetal subject. In a second aspect, the invention relates to a method of providing analgesia in a newborn subject, the method comprising administering to the subject a therapeutically effective amount of xenon. In a third aspect, the invention relates to a method of providing analgesia in a fetal subject, the method comprising administering to the mother of the fetal subject a therapeutically effective amount of xenon for both the mother and fetal subject.
Patent ES-2290509-T3 (ES)
Inventor: KREYE PAUL
IPC: C07C213/00
Filed: 2003-10-18
Granted: 2008-02-16
Abstract: Method for producing levo-salbutamol (I; alpha-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedimethanol) or its salts by asymmetric hydrogenation of prochiral salbutamone (II) in presence of rhodium and a chiral, bidentate phosphine ligand (III), optionally followed by treatment with acid to form a salt.  An Independent claim is also included for preparation of (I) by:  (1) bromination of 4-acetoxy-3-acetoxymethylacetophenone;  (2) reaction of the product with N-tert-butyl-N-benzylamine;  (3) hydrogenation of palladium catalyst (debenzylation);  (4) hydrogenation of the resulting (II) by the new method and  (5) optionally treatment with acid.
Patent ES-2474720-T3 (ES)
Title: Aparato y método para obtención de imágenes de pecho por tomografía computarizada volumétrica con haz c�nico
Inventor: NING RUOLA
IPC: A61N/
Filed: 2003-11-07
Granted: 2014-07-09
Abstract: Un dispositivo para producir una imagen de una mama (B) de un paciente (P), el dispositivo (200) comprende: - un bastidor (206) de pórtico; - por lo menos un motor (212) para mover el bastidor (206) de pórtico para formar una geometría de adquisición de datos en la que se toman datos de imágenes; - una fuente (210) de un haz de radiación (C) conectada al bastidor (206) de pórtico para moverse con el bastidor (206) de pórtico; - un detector digital bidimensional, en lo sucesivo denominado detector digital 2D (208), conectado al bastidor (206) de pórtico para moverse con el bastidor (206) de pórtico, - el detector digital 2D (208) se dispone en un recorrido del haz de radiación (C); y - una mesa (202) en la que descansa el paciente (P) mientras se toman los datos de imágenes, - la mesa (202) se configura para soportar el paciente (P) de tal manera que, durante el uso, la mama (B) se dispone entre la fuente (210) de radiación de haz cónico (C) y el detector digital 2D (208), - la mesa (202) tiene un agujero (204) por el que durante el uso se extiende la mama (B) y que se configura de tal manera que la totalidad de la mama (B) que se extiende a través del agujero (204) está en el recorrido del haz de radiación (C); en donde - el por lo menos un motor (212) se configura para mover el bastidor (206) de pórtico de modo que el detector digital 2D (208) haga un escáner volumétrico de la mama (B), caracterizado porque la mesa (202) tiene un segundo agujero (204) para permitir que un brazo del paciente (P) caiga a través del segundo agujero (204) mientras se hace el escáner volumétrico en donde la mesa (202) tiene dos agujeros (204) de mama y dos agujeros de brazo.
Patent ES-2371636-T3 (ES)
Inventor: NAITO SHINYA
IPC: H02K11/04
Filed: 2003-08-15
Granted: 2012-01-05
Abstract: The invention relates to an axial gap dynamo-electric machine comprising a rotor having a revolving shaft supported by a bearing and a magnet for generating a magnetic field, a stator yoke disposed so as to oppose the rotor, and a plurality of teeth being disposed on the magnet-opposed surface of the stator yoke substantially in the shape of a partly removed circle, wherein a removed portion is free of teeth, the partially removed circle having a midpoint at a predetermined point in relation to a center axis of the bearing and opposing the magnet at a predetermined gap.  The invention aims to provide an improved axial gap dynamo-electric machine having a structure in which some of the teeth in the stator are missing, to limit inclination of a rotor caused by such missing of the teeth.  Therefore, the invention provides that circumferential pitches among the plurality of teeth are set to differ from each other, in particular, so that an attractive force of the magnet is set to increase towards the removed portion.
Patent ES-2299752-T3 (ES)
Inventor: LINDROOS JARMON
IPC: C08F10/00
Filed: 2003-09-04
Granted: 2008-06-01
Abstract: A process for the preparation of an olefin polymerisation catalyst comprising: a) reacting an aluminoxane and a Lewis base in an optionally halogenated hydrocarbon solvent to form a particulate suspension; b) reacting said suspension with a metallocene complex in an optionally halogenated hydrocarbon solvent; and optionally c) isolating the olefin polymerisation catalyst.
Patent ES-2312852-T3 (ES)
Inventor: VINTON MARK STUART
IPC: G10L19/02
Filed: 2003-12-16
Granted: 2009-03-01
Abstract: A perceptual encoder divides an audio signal into successive time blocks, each time block is divided into frequency bands, and a scale factor is assigned to each of ones of the frequency bands. Bits per block increase with scale factor values and band-to-band variations in scale factor values. A preliminary scale factor for each of ones of the frequency bands is determined, and the scale factors for the each of ones of the frequency bands is optimized, the optimizing including increasing the scale factor to a value greater than the preliminary scale factor value for one or more of the frequency bands such that the increase in bit cost of the increasing is the same or less than the reduction in bit cost resulting from the decrease in band-to-band variations in scale factor values resulting from increasing the scale factor for one or more of the frequency bands.