Patent SG-11201408186T-A (SG)
Title: Pyridinone and pyridazinone derivatives
Inventor: HUBBARD ROBERT D
IPC: C07D213/74
Filed: 2013-06-11
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/188381 A1 (51) International Patent Classification: C07D 403/12 C07D 401/14 C07D 213/74 C07D 213/81 C07D 401/02 C07D 401/04 C07D 401/10 C07D 401/12 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) C07D 403/04 C07D 237/14 C07D 403/10 C07D 407/04 C07D 407/12 C07D 409/04 C07D 413/10 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (21) International Application Number: PCT/US2013/045151 11 June 2013 (11.06.2013) (22) International Filing Date: (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2012/076748 12 June 2012 (12.06.2012) CN 13/796,437 12 March 2013 (12.03.2013) US (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan Road, North Chicago, IL 60064 (US). (72) Inventors: HUBBARD, Robert, D.; 7684 Marker Road, San Diego, CA 92130 (US). WANG, Le; 338 East Coloni­ al Drive, Vernon Hills, IL 60061 (US). PARK, Chang, H.; 2871 N. Southern Hills Drive, Wadsworth, IL 60083 (US). SUN, Chaohong; 390 Churchill Lane, Gurnee, IL 60031 (US). MCDANIEL, Keith, F.; 26029 W. Laurel Court, Wauconda, IL 60084 (US). PRATT, John, K.; 8210 61st. Avenue, Kenosha, WI 53142 (US). SOLTWEDEL, Todd, N.; 4808 W. Strong Street, Chicago, IL 60646 (US). WENDT, Michael, D.; 1445 Maidstone Drive, Vernon Hills, IL 60061 (US). HOLMS, John, H.; 1239 Pine Grove Avenue, Gurnee, IL 60031 (US). LIU, Dachun; 1276 Georgetown Way, Vernon Hills, IL 60061 (US). SHEPPARD, George, S.; 807 Locust Road, Wilmette, IL 60091 (US). (74) Agents: BAUDE, Eric, J. et al.; AbbVie Inc., 1 North Waukegan Road, AP34-2/V377, North Chicago, IL 60064 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, [Continued on next page] (54) Title: PYRIDINONE AND PYRIDAZINONE DERIVATIVES 00 m oo oo X 2a (Ha) (Kb) T-H o CJ (57) Abstract: The present invention provides for compounds of formula (I) Wherein J is a group of formula 11a or lib: A', A , 2 A3, A4, J, and X 3 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are use - fill as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula 1. WO 2013/188381 Al I lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll lllll llll llll lllllll llll llll TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Published: KM, ML, MR, NE, SN, TD, TG). — internationa i searc h report (Art. 21(3))