baber/WOPTO huggingface dataset:
Patent NZ-538583-A (NZ)
Title: Use of isoflavonoid compounds in combination with chemotherapeutic agents
Inventor: KELLY GRAHAM EDMUND
IPC: A61K33/243
Filed: 2003-10-02
Abstract: Disclosed is the use of a compound selected from formulae (V), (VI), (VII) and (IX), wherein the substituents are as defined in the specification, in the manufacture of a medicament for increasing the sensitivity of cancer cells or a tumour to a chemotherapeutic agent. Also disclosed is a pharmaceutical composition comprising a compound of formula (V), (VI), (VII) or (IX) and a chemotherapeutic agent. Also disclosed is a platinum complex of formula (II) and pharmaceutically acceptable salts thereof, wherein at least one of RA, RB, RC and RD is XRE where RE is a compound represented by the general formula (V), (VI), (VII) or (IX), or is derived from or is a radical or ion of the compound of formula (V), (VI), (VII) or (IX), and ligates to the platinum through any one or more of the oxygen heteroatoms, or a radical of the heteroatoms defined as part of RE or alternatively by a double bond on the compound of formula (V), (VI), (VII) or (IX); and the remaining substituents are as defined in the specification.
Patent NZ-540732-A (NZ)
Title: Methods and reagents for the enhancement of virus transduction in the bladder epithelium
Inventor: RAMESH NAGARAJAN
IPC: A61K35/76
Filed: 2003-12-24
Abstract: Disclosed the use of (a) a transduction enhancing agent, wherein the transduction enhancing agent is of formula (I) or (II) as defined in the specification and (b) a composition comprising oncolytic adenovirus CG8840 in the manufacture of a medicament for treating cancer of the bladder, wherein the medicament is formulated for topical administration to a luminal surface of a bladder and wherein the medicament is formulated for separate, sequential or simultaneous administration of (a) and (b). Also disclosed are compositions of the above ingredients.
Patent NZ-543912-A (NZ)
Title: Rotary valve engine with constant volume unthrottled operation
Inventor: MENZIES MURRAY ALEXANDER
Filed: 2007-04-11
Abstract: A rotary valve spark ignition combustion engine is disclosed. The engine has a nominal compression ratio of 16:1 and has constant volume unthrottled operation. Power output is varied by varying the amount of fuel injected. The rotary valve (2) may be conical. The rotary valve design allows the combustion chamber to operate at cool enough temperatures to prevent pre-ignition during compression, and the high compression pressure ensures that fuel is completely vaporised during compression.
Patent NZ-545048-A (NZ)
Title: Chimeric antigens for breaking host tolerance to foreign antigens
Inventor: NOUJAIM ANTOINE
IPC: A61K38/095
Filed: 2004-08-06
Abstract: Provided is chimeric antigen for eliciting an immune response, the chimeric antigen comprising one or more antigen domains and an antigen presenting cell (APC) binding domain, wherein the one more antigen domains comprise at least one antigenic portion of a hepatitis B virus (HBV) surface antigen and wherein the APC binding domain comprises an antibody fragment consisting of an immunoglobulin heavy chain fragment. Further provided are pharmaceutical compositions comprising the antigen and polynucleotides coding for the antigen, methods of producing the antigen using vectors and use of the antigen in the preparation of a medicament for activating an APC, useful for treating parasitic or viral infections, including HBV.
Patent NZ-546446-A (NZ)
Title: Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists
Inventor: PEGLION JEAN-LOUIS
IPC: A61P25/00
Filed: 2006-04-07
Abstract: Piperazine derivatives of formula (I) and their optical isomers, and acid addition salts are disclosed, wherein the variables are as defined in the specification. These piperazine derivatives are suitable for use as serotonin reuptake inhibitors or as neurokinin (NK1) antagonists, and they can be used for the treatment of a condition selected from depressive states, anxiety states, impulsive disorders, aggressive behaviours, drug abuse, obesity and appetite disorders, pain and inflammation, dementias, psychotic states, disturbances of chronobiological rhythms, nausea and gastrointestinal disorders.
Patent NZ-550747-A (NZ)
Title: Shredder for the shredding of recyclable industrial waste
Inventor: LOPEZ AGUAYO ADOLFO
IPC: B02C18/12
Filed: 2004-04-29
Abstract: The invention relates to a shredder comprising a hopper (1) in which industrial waste is deposited. The base of the hopper is equipped with a waste-shredding rotor (6), while one of the longitudinal edge thereof, which are parallel to the axis (6) of the hopper outlet, is equipped with a longitudinal row of fixed blades (13) which are distributed uniformly along said edge. The spaces are provided between the fixed blades to enable the passage of moving blades (17) which are mounted to the rotor (6) by means of supports (18). In addition, half of the fixed blades (13) are disposed at a greater height than the other half, using an alternating arrangement, such that the moving blades (17) act first on one half of the blades and immediately thereafter on the other half, thereby producing a scissors-type effect which facilitates cutting and extends the useful life of such blades.
Patent NZ-555005-A (NZ)
Title: Imidazo[4,5-B]pyridin-2-one and oxazolo[4,5-B]pyridin-2-one compounds and analogs thereof as therapeutic compounds
Inventor: NICULESCU-DUVAZ DAN
IPC: A61K31/4353
Filed: 2005-10-21
Abstract: Disclosed are imidazo[4,5-B]pyridine-2-one and oxazolo[4,5-B]pyridine-2-one compounds of the formula as depicted, pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions thereof and their use in treating cell proliferation, cancer and disease of conditions that are ameliorated by the inhibition of RAF.
Patent NZ-567738-A (NZ)
Title: Pharmaceutical combination comprising atorvastatin derivatives
Inventor: SATTIGERI JITENDRA A
IPC: A61K31/40
Filed: 2006-11-08
Abstract: Disclosed herein is a combination product or medicament comprising at leaset one-substituted pyrrole derivative of the given formula, with one or more dyslipidemic agents selected from the group of etofibrate, fenofibrate, clofibrate, gemfibrozil, bezafibrate, ciprofibrate, clinofibrate or theofibrate. Said combination product is used in the treatment of cardiovascular diseases, Alzheimer's disease, obesity, diabetes or inflammatory diseases.
Patent NZ-569076-A (NZ)
Title: Vaccine comprising capsular polysaccharides conjugates from Streptococcus pneumoniae serotypes 19A and 19F
Inventor: BIEMANS RALPH LEON
IPC: A61K39/385
Filed: 2006-12-20
Abstract: An immunogenic composition that comprises Streptococcus pneumoniae capsular saccharides from serotypes 19A and 19F conjugated to bacterial toxoids. The composition further comprises conjugates of the S. pneumoniae capsular saccharides 4, 6B, 9V, 14, 18C, 22F and 23F. The bacterial toxoids can be from pneumolysin and diphtheria toxin. The composition can be used as a vaccine to treat or prevent S. pneumoniae infection or diseases.
Patent NZ-569162-A (NZ)
Title: Heterocyclic janus kinase 3 inhibitors
Inventor: INOUE TAKAYUKI
IPC: A61K31/437
Filed: 2006-12-25
Abstract: Disclosed are pyrrolo [2,3b]pyridine and imidzo [4,5-b] condensed pyridine compounds represented by the following formula (I) wherein, X is N or CR3, M is (CH2)m, m is 0 or 1, R1 is hydrogen or optionally substituted alkyl, R2 is hydrogen or alkyl, R3 is hydrogen or optionally substituted alkyl, R41 us hydrogen or a heteroaryl substituted with cyano, R42 is an optionally substituted polycyclic bridged hydrocarbon or aza-bridged cyclic hydrocarbon moiety, the further substituents are defined as in the specification. Also disclosed is a medicament containing the compound and the use of the compound in the manufacture of a medicament to treat diseases like cancer.
Patent NZ-569656-A (NZ)
Title: Fishing rod with rod mounted grip having an elliptical inner surface, and lever mounted grip
Inventor: SELFORS ROBERT
Filed: 2008-07-08
Abstract: A fishing rod is disclosed. The fishing rod 10 comprises an oblong, thin, and elastic blank 11 (blank). A reel 16 for a fishing line is seated on the rod at the rear part of the rod. A gripping device 12 comprising a fore handle 13 and a butt handle 14 is arranged on the rear part of the rod. The fore handle comprises a stable tubular body which is attached to the rear part of the rod. The fore handle is configured to allow a relative lateral movement of the rear part of the oblong, thin elastic blank in relation to the fore handle. The butt handle comprises a grip which is offset from the centre axis of the blank. The butt handle is attached to a lever 15 which forms an angle in relation to the longitudinal axis of the rod, and has a near elliptical cylindrical form with a longitudinal axis which is transverse in relation to the lever. The butt handle is intended to lie naturally in the palm of the hand. The fore handle is provided with at least one longitudinal opening or slot at least on a side of the handle where the reel is seated, so that the blank may oscillate freely upwards and downwards relative to the handle.
Patent NZ-570505-A (NZ)
Title: Improved preparation of molecular imprinted polymers
Inventor: KRISTENSEN JESPER SVENNING
IPC: C08J9/00
Filed: 2007-02-21
Abstract: Provided is a method of preparing a composition comprising molecular imprinted polymers (MIPs) having high binding capacity and specificity for a target molecule, said method comprising a) obtaining a suspension of insoluble MIPs, which bind the target molecule, and which have been prepared using the target molecule or a mimic thereof as template molecule, b) subjecting the suspended MIPs to an affinity purification procedure, wherein the template molecule or a fragment thereof or a mimic thereof is used as capture agent, c) recovering the MIPs that bind the capture agent in the affinity purification procedure while substantially excluding the capture agent and MIPs that do not bind the capture agent from the recovered product, and d) combining the MIPs recovered and optionally a carrier, vehicle or diluent to obtain said composition. Further provided is are compositions obtained by the method.
Patent NZ-571706-A (NZ)
Title: Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof
Inventor: BROWN BRIAN S
IPC: A61K31/352
Filed: 2007-04-12
Abstract: The disclosure relates to spiro-chroman compounds of formula (I), wherein the variables X1, X2, Y, R1a, R1, R2a, R2b, A1, A2, A3, and A4 are as defined in the specification. These compounds have vanilloid receptor subtype I (VR1) inhibiting activity and are suitable for use in treating pain, neuropathic pain, allodynia, pain associated with inflammation or an inflammatory disease, inflammatory hyperalgesia, bladder overactivity, and urinary incontinence.
Patent NZ-576518-A (NZ)
Title: Herbicide composition comprising isoxazoline derivatives
Inventor: YAMAJI YOSHIHIRO
IPC: A01N43/80
Filed: 2007-12-20
Abstract: Disclosed is a herbicidal composition comprising the following Component A, and the following Component B as active ingredients wherein Component A is 3-[(5-difluoromethoxy-1-methyl-3-trifluoromethylpyrazol-4-yl)methylsulfonyl]-4,5-dihydro-5,5-dimethylisoxazole (pyroxasulfone) or a salt thereof and Component B is at least one compound selected from the group consisting of: prosulfocarb, thiobencarb, and triallate.
Patent NZ-578598-A (NZ)
Title: A textured pinch-off for a mould
Inventor: MCFADYEN ROBERT CECIL
IPC: B29C49/48
Filed: 2009-07-22
Abstract: A first mould block 8.085 used in a blow moulding process which includes a flash region that has a number of projections 8.086 8.087 8.088. When used with a second mould block with complementary projections 8.081 8.082 8.083 8.084 flash material is forced into the interstices between the projections. The projections also present a first contact area intersecting the shrinkage direction of the flash material during cooling.
Patent NZ-581600-A (NZ)
Title: Fastener driving tool employing magazines feeding fasteners to a nosepiece which receives a driving force
Inventor: MOELLER LARRY M
IPC: B25C5/16
Filed: 2008-05-21
Abstract: Disclosed is a fastener driving tool. The tool includes a power source including a reciprocating driver blade, a tool nose associated with the power source for receiving the driver blade for driving fasteners (26) fed into the nose, and a magazine constructed and arranged to house a supply of the fasteners. A magazine feeder mechanism (50) associated with the magazine sequentially feeds fasteners into the nose, the feeder mechanism includes a reciprocating feed piston (58). An electromechanical retention device (110) is operationally associated with the feeder mechanism and configured for retaining the feed piston in a retracted position until the driver blade is positioned to allow fastener advancement into the nose.
Patent NZ-590843-A (NZ)
Title: Beverage forming apparatus with centrifugal pump, metering tank and brew chamber
Inventor: JACOBS WILLIAM T
IPC: A47J31/36
Filed: 2009-07-28
Abstract: A beverage forming apparatus (100) includes a storage tank (10), and a centrifugal pump (12) having an inlet connected to the storage tank by a supply conduit (11). The centrifugal pump includes a priming vent (13) located below a full level of the storage tank, permitting air to vent as liquid primes the pump. A metering tank (18) has an inlet connected to the centrifugal pump by a pump conduit, and an outlet connected to a brew chamber (20) that forms a beverage using liquid received from the metering tank. In one embodiment, a flow control valve (14), such as a check valve, may be provided in the pump conduit to allow flow from the pump to the metering tank, but resist flow in reverse. In another embodiment, a vent valve (16) in the pump conduit may be arranged to vent at least a portion of the pump conduit, e.g., to ambient air pressure.
Patent NZ-592215-A (NZ)
Title: c-MET ANTIBODIES
Inventor: DAVIES JULIAN
IPC: A61K35/00
Filed: 2009-11-18
Abstract: A monoclonal antibody that binds within the Sema domain of the alpha-chain of human c-Met. The antibody comprises the light chain CDRs defined by SEQ ID NOs 53, 54 and 56 and the heavy chain CDRs defined by SEQ ID NOs 65, 68 and 69. The antibody inhibits the activity of c-Met and can be used in the treatment of cancer.
Patent NZ-595958-A (NZ)
Title: Module case and hollow fiber membrane module using the same
Inventor: LEE KWANG-JIN
IPC: B01D61/00
Filed: 2010-06-03
Abstract: 595958 Disclosed is a hollow fiber membrane module with a module case that includes a first inner surface; a second inner surface upwardly extending from one end of the first inner surface. The second inner surface includes a separation-preventing groove to prevent the bundle of hollow fiber membranes from being separated from the module case. The module case also has a third inner surface downwardly extending from the other end of the first inner surface and a fourth inner surface connected to the third inner surface. The membrane module includes a bundle of hollow fiber membranes held together by a first potting agent formed of urethane-based resin or epoxy-based resin. The first potting agent is placed on the first inner surface of the module case. The membrane module includes a second potting agent for fixing the first potting agent which holds the bundle of hollow fiber membranes into the module case. The second potting agent is formed of urethane-based resin or epoxy-based resin. The separation-preventing groove of the module case is formed from one end of the second inner surface to the other end of the second inner surface along a longitudinal direction of the hollow fiber membranes and is filled with the second potting agent. The one end of the second inner surface is in contact with the first inner surface and the other end of the second inner surface is longitudinally opposite to the one end. The module case has an inner space for collecting filtrate produced by the hollow fiber membranes.
Patent NZ-597129-A (NZ)
Title: Hmo synthesis
Inventor: JENNEWEIN STEFAN
IPC: C12N1/00
Filed: 2009-06-08
Abstract: Disclosed is a cell able to be stably cultured in a medium, which cell is adjusted for the production of oligosaccharides, the cell being transformed to comprise at least one nucleic acid sequence coding for an enzyme involved in oligosaccharide synthesis and at least one nucleic acid sequence coding for a protein of the Sugar Efflux Transporter (SET) family, a functional homolog of the protein or functional derivative of the protein.
Patent NZ-598427-A (NZ)
Title: Stabilized amorphous forms of imatinib mesylate with cyclodextrin complex
Inventor: GONCALVES ELISABETE
IPC: A61K9/16
Filed: 2008-06-05
Abstract: Disclosed is a pharmaceutical composition comprising a formulation principle that stabilizes the amorphous form of Imatinib mesylate and amorphous Imatinib mesylate, optionally together with at least one pharmaceutically acceptable carrier, wherein the formulation principle is a cyclodextrin complex.
Patent NZ-599640-A (NZ)
Title: Pvc-free seals for twist crowns
Inventor: MANGEL DANY
IPC: C08L23/16
Filed: 2009-11-20
Abstract: This disclosure relates to a twist crown cap with a PVC-free sealing insert comprising a polymer composition comprising a combination of thermoplastic elastomers (TPE), polyolefin and white oil. The TPE is based on styrene-ethylene- butylene styrene (SEBS) and is present at 10% to 40%. The polyolefin comprises 10% to 30% linear low-density polyethylene (LLDPE), 5% to 25% low-density polyethylene (LDPE), and/or 2% to 20% copolymer consisting of polypropylene (PP) and polyethylene (PE) provided that the copolymer consisting of PP and PE comprises greater than 5% w/w to 25% w/w polyethylene of the total polyolefin. The Shore A hardness of the polymer composition is in the range of 50 to 90 and the polymer composition exhibits a compression set of 30 - 90% in the compressive deformation test analogous to ASTM D395-97 Method B at 70 °C. The disclosure also relates to the sealing insert and the use of the above polymer composition to form the twist crown cap.
Patent NZ-600260-A (NZ)
Title: Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors
Inventor: LANGGARD MORTEN
IPC: A61K31/4174
Filed: 2010-12-15
Abstract: 600260 Disclosed are 2-[(E)-2-(1-methyl-4-heteroaryl-1H-imidazol-2-yl)-vinyl]-imidazo[1,2-a]pyrimidine derivatives as represented by the general formula (I), wherein HET1 is a heteroaromatic group of formula II containing from 2 to 4 nitrogen atoms, Y is N or CH, Z is N or C, and wherein HET1 may optionally be substituted with up to three substituents R2-R4 individually selected from hydrogen, alkyl, halogen, cyano, haloalkyl, aryl, alkoxy and hydroxyalkyl, and wherein * denotes the attachment point; HET2 is a heteroaromatic group of formula III or IV: wherein Y is N, S, O or CH, X is N or CH, and wherein HET2 may optionally be substituted with up to three substituents, R5, R6 and R7 individually selected from hydrogen, alkyl, halogen, cyano, haloalkyl, aryl, alkoxy and hydroxyalkyl, and wherein * denotes the attachment point, provided that at least one of Y is other than CH and at least one of X is other than CH; L is a linker selected from -S-CH2- , -CH2-S- , -CH2-CH2-, -CH=CH-, and acetylenyl; R1 is selected from H, alkyl, alkylcycloalkyl, hydroxyalkyl, CH2CN, CH2C(O)NH2, arylalkyl, and alkyl-heterocycloalkyl; and tautomers and pharmaceutically acceptable acid addition salts thereof, and polymorphic forms thereof. Also disclosed herein are compounds such as 5,7-dimethyl-2-[2-(1-methyl-4-thiophen-3-yl-1H-imidazol-2-yl)-ethyl]-imidazo[1,2-a]pyrimidine, 5,7-dimethyl-2-{ 2-[1-(2-morpholin-4-yI-ethyl)-4-thiophen-2-yI-1H-imidazoI-2-y]-ethyl} -imidazo[1,2-a]pyrimidine, 1-(4-chloro-phenyI)-2-{ 2-[2-(5,7-dimethyI-imidazo[1,2-a]pyrimidin-2-yI)-ethyl]-4-thiazol-5-yI-imidazol-1-yI} -ethanol, 8-methoxy-2-[2-(1 -methyl-4-thiazol-5-yI-1H-imidazol-2-yl)-ethyl]-[1,2,4ltriazolo[1,5-a]pyridine, 8-fluoro-2-{ 2-[1-methyl-4-(5-methyl-furan-2-yl)-1H-imidazol-2-yI]-ethyl} -[1,2,4]triazolo[1,5-a]pyridine. Further disclosed is a medicament which comprises a compound as defined above for the treatment of a neurodegenerative or psychiatric disorder.
Patent NZ-601105-A (NZ)
Title: Insecticidal protein combination comprising cry1ab and cry2aa for controlling european corn borer, and methods for insect resistance management
Inventor: STORER NICHOLAS P
IPC: A61K36/899
Filed: 2010-12-16
Abstract: Disclosed is a transgenic plant having transgenes encoding insecticidal proteins, wherein the insecticidal proteins are a Cry1Ab insecticidal protein and a Cry2Aa insecticidal protein. Also disclosed is a method of controlling a European cornborer insect by providing said insect with said plant.
Patent NZ-603161-A (NZ)
Title: Superior efficacy of cd37 antibodies in cll blood samples
Inventor: HEIDER KARL-HEINZ
IPC: C07K16/28
Filed: 2011-07-15
Abstract: A method of depleting CD37 expressing B cells from a population of TP53 deficient cells comprising administering to said population of cells a CD37 antibody or a pharmaceutical composition comprising a CD37 antibody and a pharmaceutically acceptable excipient or carrier, wherein said method is carried out in vitro, wherein said antibody has a heavy chain comprising the amino acid sequence of SEQ ID NO:5 and a light chain comprising the amino acid sequence of SEQ ID NO:6, and wherein said population of cells is from a high risk patient suffering from a B cell malignancy, wherein said high risk patient is a patient with 17p 13 deletion.
Patent NZ-609283-A (NZ)
Title: Compounds as c-met kinase inhibitors
Inventor: CHEN GUOQING PAUL
IPC: C07D405/12
Filed: 2011-09-09
Abstract: Disclosed herein is a compound of formula I, wherein the variables are defined in the specification, and the use thereof in the treatment of a neoplastic or proliferative or inflammatory disease, or a transplantation disorder, especially those caused by excess or inappropriate tyrosine kinases. Examples of the compound include 4-methoxybenzyl-1-((4-(2-fluoro-4-(1-(4-fluorophenylcarbamoyl)cyclopropane-carboxamido)phenoxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropylcarbamate, and N-(3-fluoro-4-(6-methoxy-7-((1-(tetrahydro-2H-pyran-4-ylamino)cyclopropyl)methoxy) quinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide.