Patent SG-11201810872U-A (SG)
Title: Composition and method for reducing neutropenia
Inventor: HUANG LAN
IPC: A61P35/00
Filed: 2017-06-05
Abstract: ANC3 ce lls /µ L) 5.0 - 4.5 - 4.0 - 3.5 - 3.0 - 2.5 - 2.0 - 1.5- 1.0- 0.5 - 0.0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 December 2017 (14.12.2017) WIP0 I PCT oimitia inn DID E aIIIII0II111111 0IIIIII (10) International Publication Number WO 2017/214052 Al cP' tc` Q r AO x oS Qr C (51) International Patent Classification: A61K 31/40 (2006.01) A61K 31/496 (2006.01) A61K 31/04 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2017/035991 (22) International Filing Date: 05 June 2017 (05.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/346,426 06 June 2016 (06.06.2016) US 62/454,628 03 February 2017 (03.02.2017) US (71) Applicant: BEYONDSPRING PHARMACEUTICALS, INC. [US/US]; 28 Liberty Street, 39th Floor, New York, NY 10005 (US). (72) Inventors: HUANG, Lan; 28 Liberty Street, 39th Floor, New York, NY 10005 (US). LLOYD, George, Kenneth; 28 Liberty Street, 39th Floor, New York, NY 10005 (US). MOHANLAL, Ramon; 28 Liberty Street, 39th Floor, New York, NY 10005 (US). (74) Agent: MALLON, Joseph, J.; Knobbe, Martens, Olson & Bear, LLP, 2040 Main Street, 14th Floor, Irvine, CA 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: COMPOSITION AND METHOD FOR REDUCING NEUTROPENIA p=0.0584; n=5 per group / / z *sc2 •Q e e cc' cc' 0 4 D <1,* A • Il .c , • AS <2\" N \‘') ,,e 11) og 0 .R 71' 1-1 N FIG. 1 N ,-, © (57) : Disclosed herein are methods of reducing neutropenia that is caused by chemotherapy or radiation therapy by admin- istering plinabulin to a subject. [Continued on next page] WO 2017/214052 Al MIDEDIMOMMIMMEM0011010HOIREIHINVOIMIE Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))