baber/WOPTO huggingface dataset:
Patent RU-2670128-C2 (RU)
Title: Способ генетической регистрации и коррекции нейрогенеза на основе генетических конструкций для трансфекции нейронов
Inventor: Kasymov Vitalij Anvarovich
IPC: A61P25/00
Filed: 2016-12-16
Granted: 2018-10-18
Abstract: Изобретение относится к области биотехнологии. Предложен способ генетической регистрации и коррекции нейрогенеза на основе генетических конструкций для трансфекции нейронов, при котором осуществляют трансфекцию катехоламинергических нейронов генетической конструкцией SEQ ID NO: 4, обладающей способностью к стимуляции нейрогенеза и (или) ингибированию нейрональной дегенерации. Изобретение позволяет осуществлять клеточно- и фентип-специфическую трансфекцию катехоламинергических нейронов с целью таргетного контроля внутриклеточных каскадов, а также осуществлять визуализацию in vitro трансфецированных клеток за счет встраивания в разрабатываемую генетическую конструкцию генетически кодируемого кальциевого индикатора. Изобретение может быть использовано в области медицины для терапии нейродегенеративных заболеваний. 2 ил..
Patent RU-2701257-C2 (RU)
Title: Skin care composition delivery device
Inventor: PUTNINS MATTHEW ERIC
IPC: A45D40/16
Filed: 2015-05-12
Granted: 2019-09-25
Abstract: FIELD: medicine; hygiene. 
     SUBSTANCE: invention relates to devices for delivery of skin care compositions, in particular active components and cosmetic components. Multilayer system for delivering a skin care composition contains a flexible coating layer, a first adhesive layer and a reservoir. Flexible cover layer forms upper surface of delivery system and is attached to connection layer with possibility of removal, wherein connecting layer has upper surface facing flexible cover layer, opposite lower surface, outer perimeter and forms inner free volume, substantially closed by flexible cover layer. First adhesive layer is placed on the lower surface of the delivery system and protected with a detachable protective coating. Reservoir is attached to lower surface of flexible cover layer and extending from it into inner free volume, wherein the reservoir is arranged in fluid communication with the inner free volume such that the skin care composition enters the internal free volume from the moment of reservoir rupture. 
     EFFECT: invention is aimed at increasing accuracy of ingress of used low-viscosity liquid on processed part of skin. 
     11 cl, 6 dwg
Patent RU-2685845-C2 (RU)
Inventor: LANG GERHARD
IPC: A24B15/22
Filed: 2015-08-19
Granted: 2019-04-23
Abstract: Изобретение относится к способам получения аэрозольобразующих субстратов, содержащих сниженное количество специфичных для табака нитрозаминов. Способ уменьшения количества по меньшей мере одного специфичного для табака нитрозамина в вырабатывающем аэрозоль субстрате, при этом способ включает обеспечение табачной пульпы, содержащей по меньшей мере один специфичный для табака нитрозамин; облучение табачной пульпы ультрафиолетовым светом и высушивание табачной пульпы с получением вырабатывающего аэрозоль субстрата. Техническим результатом изобретения является снижение времени и затрат на производство табачных материалов. 5 з.п. ф-лы, 2 пр., 3 ил.
Patent RU-2699551-C2 (RU)
Title: High-capacity structures and monoliths via paste imprinting
Inventor: FOWLER TRACY A
IPC: B01D53/04
Filed: 2015-10-12
Granted: 2019-09-06
Abstract: FIELD: chemistry. 
     SUBSTANCE: present invention relates to a structure for use in catalysis and adsorption processes, comprising multilayer coated substrates and channels between adjacent multilayer coated substrates, in which each multilayer coated substrate comprises a substrate having a first and a second side, and a composite material on at least a first side of the substrate, wherein said composite material comprises an active material selected from a catalyst or adsorbent, and having distinctive features on the surface of the composite material, selected from grooves, hills, plateaux, columns, cylinders, hillocks, cones or any combination thereof, created by means of printing, forming, drawing or three-dimensional printing; and wherein the channels are formed by contact of the distinctive features in the coating on the first side of the multilayer structure with the side of the adjacent multilayer structure. Also, the invention relates to a method of making such a structure and to a embodiment thereof. 
     EFFECT: technical result is creation of structure for use in catalysis and adsorption processes, having higher density of cells and larger volume fraction of active material. 
     30 cl, 20 dwg, 3 ex
Patent RU-2705013-C2 (RU)
Inventor: LASSERR Sebasten
IPC: H04N5/355
Filed: 2016-01-25
Granted: 2019-11-01
Abstract: Изобретение относится к вычислительной технике. Технический результат – обеспечение обратной совместимости изображений с SDR. Способ кодирования цветного изображения, имеющего цветовые компоненты (Ec), содержит этапы: получения компоненты яркости (L) на основе: значения модуляции (Ba) из яркости (Y) цветного изображения; масштабированной яркости, полученной путем деления яркости (Y) цветного изображения на значение (Ba) модуляции; компоненты (L) яркости путем применения нелинейной функции к масштабированной яркости так, что динамика компонента (L) яркости снижается по сравнению с динамикой масштабированной яркости; получения двух компонент (C1, C2) цветности, на основе: коэффициента (r(L(i)), который зависит от значения пикселя (i) компонента (L(i)) яркости и значения (Y(i)) яркости, имеющего то же местоположение пикселя (i) в цветном изображении; промежуточного цветового компонента (E'c) путем умножения каждого цветового компонента (Ec) на коэффициент (r(L(i)); и двух компонентов цветности (C1, C2), полученных из упомянутого промежуточного цветового компонента (E'c); и кодирование яркости (L) и двух компонент цветности (C1, C2). 8 н. и 15 з.п. ф-лы, 9 ил., 1 табл.
Patent RU-2723047-C2 (RU)
Title: Agent for treating multiple myeloma (mm)
Inventor: LECLAIR St&eacutephane
IPC: A61P35/00
Filed: 2016-05-13
Granted: 2020-06-08
Abstract: FIELD: biotechnology.SUBSTANCE: what is declared is the use of CD38 specific antibody for treating multiple myeloma, wherein said antibody is introduced in dose of 8 mg/kg to 16 mg/kg once a week (q1w) for at least eight weeks.EFFECT: invention provides a significant improvement of the overall frequency and length of the response to the treatment in the patients suffering multiple myeloma.7 cl, 11 dwg, 4 tbl, 6 ex
Patent RU-2694468-C2 (RU)
Title: Device for taking blood or blood preparation
Inventor: ANITUA ALDECOA EDUARDO
IPC: A61B5/154
Filed: 2016-05-23
Granted: 2019-07-15
Abstract: FIELD: medicine. 
     SUBSTANCE: device comprises: test tube (10) extending along longitudinal axis (11) and comprising side wall (12), a closed distal end (13), proximal end (14) opposite distal end (13), and inner cavity (15), communicating with outer space through opening (16) on proximal end (14); piston assembly (50; 250; 350) moved along inner cavity (15) of test tube (10), wherein piston assembly (50; 250; 350) limits space (15a) between piston assembly (50; 250; 350) and distal end (13) of test tube (10); handle assembly (30; 130; 330) comprising gripping portion (32, 132) and end portion (34; 134; 334) and pierceable sealing member (70; 270; 370). Said device (1; 100; 200; 300) is configured to receive a movement position in which handle assembly (30; 130; 230) moves piston assembly (50; 150; 250) to distal end (13) and is not fixed to piston assembly (50; 150; 250) and in which air in space (15a) is forced through piston assembly (50; 150; 250) and/or through space between piston assembly (50; 150; 250) and side wall (12) of test tube (10). Said device (1; 100; 200; 300) is configured to receive an offset position in which end portion (34; 134; 334) of handle assembly (30; 130; 230) is fixed to piston assembly (50; 150; 250) and pulls piston assembly (50; 150; 250) to proximal end (14) and in which piston assembly (50; 150; 250) and pierceable sealing element (70; 270; 370) seal space (15a). 
     EFFECT: invention refers to medical equipment, namely to devices for blood sampling or blood preparation. 
     21 cl, 30 dwg
Patent RU-2709453-C2 (RU)
Title: Quasi-resonance single-cycle forward-path voltage converter with switching at zero current
Inventor: Goryashin Nikolaj Nikolaevich
IPC: H02M3/155
Filed: 2018-01-09
Granted: 2019-12-18
Abstract: FIELD: electrical engineering.SUBSTANCE: disclosed power supply comprises a quasi-resonance single-cycle forward-path voltage converter with switching at zero current and half-wave resonance cycle, comprising primary single-cycle inverter, inverter control circuit, pulse transformer, resonant circuit, half-wave rectifier, output inductive-capacitive filter. Distinctive feature of the source is that control of the key element of the inverter, which can be built according to the "skew bridge" scheme, containing two switches, or according to the scheme of the single-cycle forward-path converter, containing one transistor key, is implemented so that irrespective of input voltage and load power duration of key control pulse is always equal to duration of half-wave of resonant cycle current. Technical result consists in that the duration of the open state of the primary inverter switches will always be the lowest possible from the point of view of the used resonance mode.EFFECT: amplitude of magnetizing current of primary winding of high-frequency transformer, and hence losses for remagnetization always will be minimum.1 cl, 2 dwg
Patent RU-2734631-C2 (RU)
Title: Lampshade and method of its manufacturing
Inventor: Teplyakov Sergej Nikitovich
IPC: F21V1/06
Filed: 2018-01-19
Granted: 2020-10-21
Abstract: FIELD: furniture production. 
     SUBSTANCE: lampshade contains rings, two internal brace spreaders and separate covers. Inside the jacket there are two spacers of the same and different length and configuration in form of any broken convex and/or concave line. End section of each brace is arranged in the appropriate ring and fixed therein. Spacers located inside different covers are connected by end sections by means of ring. Each cover is stretched without creases along its entire surface. In accordance with selected volumetric shape lampshade individual covers are made of segments. Covers can be made integral in form of a sleeve. Internal jacket brace is brought inside said jacket. Then the inner spreaders of the jacket are fixed in the ring with formation of the shade surface of rupture and, if necessary, identical by configuration adjacent struts of adjacent covers are fixed to each other by means of attachment in places of contact of covers to form corrugated surface of lampshade. 
     EFFECT: lampshade and method of its manufacturing are proposed. 
     4 cl, 8 dwg
Patent RU-2722490-C2 (RU)
Inventor: VENKATASURIYA PAVAN
IPC: C21D9/46
Filed: 2016-12-21
Granted: 2020-06-01
Abstract: Изобретение относится к области металлургии. Способ производства листовой стали, обладающей микроструктурой, состоящей из от 71 до 91% суммарного количества мартенсита и бейнита, от 9 до 13% остаточного аустенита и, самое большее, 20% феррита, включает получение холоднокатаной листовой стали, при этом химический состав стали содержит в мас.%: 0,13% ≤ С ≤ 0,22%, 1,2% ≤ Si ≤ 2,3%, 0,02% ≤ Al ≤ 1,0%, причем 1,25% ≤ Si + Al ≤ 2,35%, 2,4% ≤ Mn ≤ 3%, Ti < 0,05%, Nb < 0,05%, при этом остаток представляет собой Fe и неизбежные примеси, отжиг листовой стали при температуре отжига ТА таким образом, чтобы получить структуру, содержащую от 80 до 100% аустенита и от 0 до 20% феррита, - закалку листа при скорости охлаждения, заключенной в пределах от 20 до 50°С/с, вплоть до температуры закалки QT в диапазоне от 240 до 310°С, - нагревание листа вплоть до температуры распределения РТ в диапазоне от 400 до 465°С и сохранение листа при данной температуре в течение периода времени Pt в диапазоне от 50 до 250 с, - незамедлительное охлаждение листа вплоть до комнатной температуры. 4 н. и 26 з.п. ф-лы, 4 табл.
Patent RU-2737819-C2 (RU)
Inventor: LYU Sin
IPC: F16C33/36
Filed: 2017-05-27
Granted: 2020-12-03
Abstract: FIELD: machine building. 
     SUBSTANCE: invention relates to the field of seals, and more specifically to the cassette sealing structure, which is mainly used for seals of bearings in the field of railway transport, and a tapered roller bearing, in which a cartridge sealing structure is used. Sealing structure (1) of box-like type is mainly ring-shaped and contains oil-reflecting ring (11) and sealing ring, wherein sealing ring comprises frame (12) and sealing section (13) attached to frame (12), oil-reflecting ring (11) is equipped with axial part, which extends along axial direction, oil-reflecting ring (11) is additionally equipped with first centrifugal structure, which is located closer to inner side along axis in comparison with axial part of oil-reflecting ring (11), first centrifugal structure is equipped with first bent section (11a1), which extends towards the axially inner side and, simultaneously, extends towards the radially outer side, sealing section (13) comprises the first sealing closing section (131), which is located on the radially outer side of the first bent section (11a1) and which is located at a distance from first bent section (11a1), and the first sealing closing section (131) at least partially extends towards the axially inner side in the axial direction to a position, which is located at same level with first bent section (11a1). Further, a tapered roller bearing comprising a box-type sealing structure (1) is provided. Sealing structure (1) of box-type type and conical roller bearing improve sealing action for oil medium. 
     EFFECT: disclosed are a cassette sealing structure and a tapered roller bearing. 
     8 cl, 4 dwg
Patent RU-2758256-C2 (RU)
Title: Azaindazole compounds for use in injuries of tendons and/or ligaments
Inventor: BURSULAYA BADRY
IPC: A61P19/02
Filed: 2017-09-21
Granted: 2021-10-27
Abstract: FIELD: medicine. 
     SUBSTANCE: invention relates to a compound of the formula (I) in free form having activity as inducers of scleraxis, a tenomodulin gene and/or type I collagen (Col1a2), a pharmaceutical composition based on them and their use in the preparation of a drug for the treatment of tendon and/or ligament injury that are susceptible to the induction of scleraxis, the tenomodulin gene and/or type I collagen (Col1a2). In the general formula (I), R 1  is selected from C 1 -C 3 alkyl and halogen; R 2  is selected from NHSO 2 (CH 2 ) n R 3  or SO 2 NR 5 R 6 ; n is 0 or 1; R 3  is selected from phenyl optionally substituted once or twice with R 4 ; C 3 -C 6 cycloalkyl optionally substituted with hydroxyl; a condensed 12-element bicyclic aromatic ring system; R 4  is independently selected from halogen, C 1 -C 3 alkoxy, cyano, C 1 -C 3 alkyl, hydroxyl, halogenC 1 -C 3 alkyl, NHC(O)CH 3 , halogenC 1 -C 3 alkoxy, SO 2 NH(CH 3 ); and/or two R 4  with adjacent carbon atoms form 5- or 6-element heterocyclic non-aromatic ring containing one or two heteroatoms selected from N and O, while the specified heterocyclic ring is condensed with phenyl ring and is optionally substituted with C(O)CH 3 ; R 5  is selected from H, C 1 -C 3 alkyl; R 6  is selected from C 3 -C 6 cycloalkyl optionally substituted once or twice with R 7 ; phenyl optionally substituted once or twice with halogen; C 1 -C 6 alkyl optionally substituted with hydroxyl; 4-6-element heterocyclic non-aromatic ring containing one heteroatom, which is S, optionally substituted twice with oxo; benzyl; R 7  is independently selected from hydroxyl, halogenC 1 -C 3 alkyl, halogen, C 1 -C 3 alkyl, hydroxyC 1 -C 3 alkyl; or R 5  and R 6  together with N atom, to which they are attached, form 5- or 6-element heterocyclic non-aromatic ring optionally containing one additional heteroatom, which is N, while the specified ring is optionally substituted once, twice or thrice with R 8 ; 6-8-element saturated bicyclic ring system; R 8  is independently selected from halogen; hydroxyC 1 -C 3 alkyl; C(O)NH 2 ; hydroxyl; halogenC 1 -C 3 alkyl optionally substituted with hydroxyl; phenoxy; SO 2 C 1 -C 3 alkyl.  
     EFFECT: preparation of a drug for the treatment of tendon and/or ligament injury. 
       (I) 
     16 cl, 3 tbl, 1 dwg, 97 ex
Patent RU-2749521-C2 (RU)
Title: Aerosol generating device and aerosol generating system
Inventor: REEVELL TONY
IPC: A24F40/53
Filed: 2017-12-21
Granted: 2021-06-11
Abstract: FIELD: aerosol generators. 
     SUBSTANCE: invention relates to aerosol generating devices and aerosol generating systems containing such a device. The aerosol generating device (1) comprises a device housing (2) containing a receiving chamber (3) adapted to accommodate any of consumable component of the first type (41) and consumable component of the second type (42). The receiving chamber contains the first element (31) to accommodate consumable component of the first type and contains the second element (32) to accommodate consumable component of the second type, or contains an element switch to select between the first element and the second element. The first and second elements differ in at least one of the shape, size, or position in the receiving chamber. The device further comprises an aerosol generation system connected to at least part of the receiving chamber, and a detection system designed to detect the presence of a first-type consumable component or a second-type consumable component inserted into the receiving chamber. The aerosol generation system is designed to interact with any of the consumable components of the first type or the second type after it is inserted into the receiving chamber to generate the aerosol.  
     EFFECT: invention makes it possible to provide the user with more options for choice associated with the use of different consumable components.  
     14 cl, 37 dwg
Patent RU-2770300-C2 (RU)
Title: Новые полиморфные формы тримебутина малеата, способ получения и применения
Inventor: SYROV KIRILL KONSTANTINOVICH
IPC: A61K31/194
Filed: 2019-10-17
Granted: 2022-04-15
Abstract: Изобретение относится к применению полиморфной формы тримебутина малеата для изготовления лекарственного средства в твердой форме для лечения заболеваний желудочно-кишечного тракта, где упомянутая полиморфная форма имеет на порошковой рентгеновской дифрактограмме характеристические пики при следующих углах 2θ, ° (± 0,1°): 8,7; 11,6; 13,2; 15,3, 21,5; 23,4; 27;9; 30,8. Также изобретение относится к применению  фармацевтической композиции, обладающей спазмолитической активностью, для изготовления лекарственного средства в твердой форме для лечения заболеваний желудочно-кишечного тракта, где упомянутая композиция содержит в терапевтически эффективном количестве полиморфную форму тримебутина малеата, имеющую характеристические пики на порошковой рентгеновской дифрактограмме при следующих углах 2θ, ° (± 0,1°): 8,7; 11,6; 13,2; 15,3, 21,5; 23,4; 27;9; 30,8, и по меньшей мере один фармацевтически приемлемый носитель. Технический результат – стабильная при хранении, негигроскопичная, хорошо растворимая полиморфная форма тримебутина малеата, предназначенная для изготовления лекарственного средства. 2 н. и 1 з.п. ф-лы, 1 ил., 4 табл., 8 пр.
Patent RU-2754876-C2 (RU)
Inventor: EUN SO-YOUNG
IPC: A61K39/395
Filed: 2018-03-23
Granted: 2021-09-08
Abstract: Изобретение относится к области биохимии, в частности к анти–CEACAM1 антителу или его фрагменту. Способ лечения рака, способ ингибирования пролиферации CEACAM1–экспрессирующих опухолевых клеток, с помощью указанного антитела; и применение указанного антитела для предупреждения или лечения рака Изобретение позволяет эффективно лечить рак, ассоциированный с сверхэкспрессией CEACAM1. 10 н. и 18 з.п. ф-лы, 29 ил., 3 табл., 6 пр.
Patent RU-2763300-C2 (RU)
Title: Device for stabilizing firearms
Inventor: PASPALIARIS VASILIS
IPC: F41A21/36
Filed: 2018-08-13
Granted: 2021-12-28
Abstract: FIELD: armament. 
     SUBSTANCE: device for stabilizing firearms contains an electric engine made with the possibility of rotating a flywheel around the axis of rotation, a power source feeding the electric engine and a control button. The electric engine, the flywheel and the power source are located inside a casing. The device for stabilizing firearms contains mounting elements located on the outer surface of the casing for attaching (with or without the possibility of disconnecting) the device to the firearm and a mounting bracket for attaching accessories.  
     EFFECT: improvement of the stability and accuracy of firearms. 
     24 cl, 17 dwg
Patent UA-42196-C2 (UA)
Title: Method for assessment of stress-restricting system
Inventor: BABOV KOSTIANTYN DMYTROVYCH
IPC: G01N33/50
Filed: 2000-10-24
Abstract: The invention relates to the medicine, namely to the methods for diagnosing and monitoring the state of the patients in dynamics upon the surgery, the injuries, the myocardial infarction, etc. The method for the assessment of stress-restricting body system comprises the estimation of the overall state of the antioxidant activity. The mediator component of the neurohumoral system is assessed by the blood serotonin content. The energy metabolism isassessed by the ratio between the activities of succinate dehydrogenase and transaminase of gamma-aminobutyric acid.
Patent UA-73947-C2 (UA)
Title: Alkoxysubstituted benzimidazoles, pharmaceutical compositions containing them, and a method for application thereof
IPC: A61K9/00
Filed: 2000-08-25
Abstract: Compounds represented by formula (Ia) are disclosed by the invention, along with compositions and complexes thereof, optionally in combination with compounds of formula (Ib). Pharmaceutical formulations and methods of making and using such compounds are also disclosed.
Patent UA-73587-C2 (UA)
Title: A method for the preparation of quinoline derivatives
IPC: C07D215/26
Filed: 2001-06-26
Abstract: Compounds of formula (I), wherein r| is hydrogen or chlorine and R; is hydrogen, C1-C8alkyl, or C1-C8alkyl substituted by C1-C6alkoxy or by C3-C6alkenyloxy, can be prepared by: a) introducing the major portion of the amount to be reacted of a compound of formula (II) into a solvent mixture comprising at least one organic solvent capable of forming an azeotrope with water, and at least one aprotic-dipolar solvent; b) metering in an aqueous strong base in an amount equivalent to that major portion of the total amount of the compound of formula (II); c) adding the remaining portion of the amount to be reacted of the compound of formula (II); d) adding a weak base in an amount that is at least equivalent to that remaining portion; e) removing the water from the reaction mixture by azeotropic distillation; f) adding a compound of formula (III), wherein R; is as defined for formula (I); and g)isolating the resulting compound of formula (I) from the reaction mixture.
Patent UA-79183-C2 (UA)
Title: Method for fuel supply to two-zone combustion chamber of two-cascade gas-turbine engine
Inventor: VANTSOVSKYI VOLODYMYR GRYGOROV
IPC: F02C9/26
Filed: 2005-07-11
Abstract: A method for fuel supply to two-zone combustion chamber of two-cascade gas-turbine engine includes control of fuel flow rate to basic and supplementary burning zones. Beginning from mode of engine heating and to range of relative frequency of rotation of rotor of turbo-compressor of high pressure = 88 - 92 %, relative flow rate of fuel to auxiliary burning zone of combustion chamber is supplied permanently at amount of = 14 - 18% of total nominal fuel flow rate to both burning zones. Then flow rate or fuel to auxiliary burning zone is continuously decreased by 2 - 3 % and within the range of =95 - 100% it is maintained constant. To the main combustion zone one supplies fuel flow rate that is equal to difference between total fuel flow rate to both burning zones and fuel flow rate to auxiliary zone.