baber/WOPTO huggingface dataset:
Patent CA-2369243-A1 (CA)
Title: Brake shoe proximity sensor
Inventor: BORUGIAN DENNIS A
IPC: F16D66/02
Filed: 2002-01-24
Abstract: A brake system with an integral proximity sensor for providing an indication of a condition of the brake system. The brake system includes a brake drum, a brake shoe, a brake pad, and a position sensor. The brake pad is connected to a pad mounting surface of the brake shoe. The brake pad and brake shoe are movable from a disengaged position, where the brake pad is spaced apart from the brake drum to an engaged position, where the pad is in forcible engagement with the brake drum. The position sensor is coupled to the brake shoe for sensing the position of the brake shoe with respect to the position sensor. The position of the brake shoe with respect to the position sensor provides an indication of one or more conditions of the brake system.
Patent CA-2369464-A1 (CA)
Inventor: HARRIS PAUL
IPC: C09D201/02
Filed: 2000-07-27
Abstract: The present invention provides a curable coating composition that includes a t least three components. The coating composition includes a component (a) having at least one carbamate group or urea group and having a lactone or hydroxy carboxylic acid moiety. The second component (b) of the coating composition is the reaction product of a polyol having at least one branch point, i.e., carbon bonded to at least three other carbons, with a lactone o r hydroxy carboxylic acid. The third component of the coating composition is a  curing agent that is reactive with the first two components. Preparation of coated articles using the compositions of the invention is also disclosed.</ SDOAB>
Patent CA-2373187-A1 (CA)
Title: Controller for a printer module
Inventor: LAPSTUN PAUL
IPC: B41J2/525
Filed: 2000-05-24
Abstract: A controller for a printer module having a printhead that prints an image on printable media including a low speed central processing unit with associated program memory storing program steps for execution by the central processing unit to operate the printer module and associated scratch memory to store program variables. An image to be printed is stored in an image storage memory of approximately 1.3Mbytes. An image access unit accesses the image and transfers the image to a printhead interface on command from the central processing unit. The printhead interface transforms the image to a 1600dpi dithered CMY image for printing by a monolithic printhead. The controller also includes one or more interface units communicating with components of said printer module under control of the central processing unit. A Serial Bus interface communicates with the Serial Bus of a compact printer system to transfer data and power between modules. In one application, a camera module captures an image which is transferred to the image storage memory of the printer module for printing by the printhead.
Patent CA-2373500-A1 (CA)
Title: Hydroxamic acid derivatives as matrix metalloprotease inhibitors
Inventor: BARTA THOMAS E
IPC: C07D309/10
Filed: 2000-05-12
Abstract: A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity. A contemplated compound corresponds in structure to formula (a) wherein W and the R groups are defined elsewhere.
Patent CA-2373618-A1 (CA)
Inventor: GOLDENBERG DAVID M
IPC: A61K39/00
Filed: 2000-05-10
Abstract: Les manifestations malignes de lymphocytes B, telles que le sous-type à lymphocytes B des lymphomes non hodgkiniens et de la leucémie lymphocytaire chronique, contribuent pour une grande part à la mortalité par cancer. La réponse des manifestations malignes de lymphocytes B à plusieurs formes de traitement est mitigée. Des méthodes traditionnelles de traitement des manifestations malignes des lymphocytes B, y compris la chimiothérapie et la radiothérapie, ont une efficacité limitée à cause d'effets secondaires toxiques. L'immunothérapie avec des anticorps anti-CD20 a également connu un succès limité. Cependant, l'utilisation d'anticorps se liant à l'antigène de CD22 ou CD19 représente un moyen efficace de traitement des manifestations malignes de lymphocytes B, telles que des formes indolentes et agressives de lymphomes de cellules B, et des formes aiguës et chroniques de leucémies lymphatiques. En outre, une immunothérapie avec des anticorps anti-CD22 et/ou anti-CD19 requiert des doses relativement faibles de protéines d'anticorps, et peut être utilisée efficacement dans des thérapies multimodales.
Patent CA-2373903-A1 (CA)
Title: Increasing plant seed production
Inventor: GORING DAPHNE
IPC: C12N9/12
Filed: 2002-02-28
Abstract: The invention includes PERK (Proline-rich Extensin-like Receptor Kinase) nucleic acid molecules and polypeptides. A receptor-like protein kinase designated PERK1 (Proline-rich Extensin-like Receptor Kinase 1) was isolated from a (-pistil cDNA library of Brassica napus. The deduced PERK1 protein is comprised of a cytoplasmic domain that contains all of the conserved amino acids prevalent among serine/threonine kinases, a transmembrane domain and an extracellular domain with sequence similarity to the extensin family of plant cell wall proteins. Northern blot analysis demonstrated that PERK1 mRNA accumulated rapidly in leaf and stem tissue of B. napus in response to wounding and treatment with salicylic acid. In contrast, no significant accumulation of PERK1 mRNA was detected following treatment with methyl jasmonate. The rapidity of PERK1 mRNA accumulation in response to these treatments shows a role in plant defense signaling:
Patent CA-2374441-A1 (CA)
Inventor: MCLEAN CHRISTOPHER
IPC: B01D53/047
Filed: 2000-06-12
Abstract: La présente invention concerne un module rotatif (10) permettant la mise en oeuvre d'un processus d'adsorption modulée en pression. Ce module comprend un stator (14) pourvu d'une pluralité de compartiments fonctionnels débouchant dans les façades de soupapes du stator, un rotor (11) couplé rotatif au stator et incluant une pluralité d'orifices débouchant dans les façades de soupapes du rotor, et un joint de soupape du type à reprise automatique de jeu monté entre les façades de soupapes du stator et du rotor de façon à réguler le débit de gaz entre le stator et le rotor. Chaque joint de soupape, qui présente une face étanche venant contre la face étanche correspondante des façades de soupape du rotor, est capable de rotation par rapport à la façade considérée de soupapes du rotor de façon à moduler le débit de gaz en fonction du jeu entre la face du joint et la façade de soupapes correspondante du rotor. Chaque joint de soupape comprend également un passage en communication avec l'un des compartiments fonctionnels de façon à faire varier le jeu en fonction d'un différentiel de pression entre le passage et une ouverture se rapprochant. De cette façon, le joint de soupape conserve un profil lisse de transition de pression pendant l'inversion des chemins bas entre compartiments fonctionnels. Il en résulte que l'on ne modifie pas l'équilibre entre le matériau adsorbant et le front de transfert de masse du gaz, et ce, tout en augmentant l'efficacité du processus de séparation des gaz.
Patent CA-2375095-A1 (CA)
Inventor: BUCKLE ASHLEY MAURICE
IPC: A61K48/00
Filed: 2000-05-26
Abstract: A GroEL chaperone polypeptide, or homologue thereof, or fragment thereof having protein refolding activity, comprising one or more amino acid modifications at any one of amino acid residues (207, 212, 217, 223, 233, 26 7, 271, 294, 305, 308 and 326) of the GroEL amino acid sequence shown as SEQ I. D. No. 1 or their equivalent positions in other homologous chaperone polypeptid es is provided.
Patent CA-2380941-A1 (CA)
Title: Therapeutic and prophylactic compositions including catalytic biomimetic solids and methods to prepare and use them
Inventor: COLIC MIROSLAV
IPC: A61K31/695
Filed: 2000-08-16
Abstract: The invention discloses therapeutic and prophylactic compositions based on synthetic solid catalysts such as zeolites, clays, silicates, silicas and double hydroxides. These solids can be used to treat numerous disease conditions such as diabetes, arthritis and other autoimmune diseases, cancer, skin diseases, microbial infections etc. The invention also describes methods to produce such products and use them independently or in combination with other pharmaceutically and biologically active ingredients. Such catalysts are designed so to imitate biological catalytic systems (enzymes, antigen presenting cells, delayed active component release, cell organeles, etc.) and are, therefore, biomimetic.
Patent CA-2383831-A1 (CA)
Title: Method for increasing the yield of recombinant proteins in microbial fermentation processes
Inventor: LIN HONG YING
IPC: C12M1/36
Filed: 2000-09-13
Abstract: The use of prior art methods for producing recombinant proteins in fed-batch  fermentations often results, after the induction of the recombinant product synthesis, in an overgrowth of the culture due to plasmid-free cells and lea ds to a reduction of the specific product yield. The yield of recombinant proteins is thus increased by lowering or increasing, in a constantly brief manner, the concentration of the carbon/energy source in the culture. The oscillations are generated by altering the dosage rate of the feed solutions  containing the carbon/energy source. This method is suited for all microorganisms which are cultivated using carbon-limited fed-batch.
Patent CA-2384267-A1 (CA)
Title: Formation of oligomeric or organophosphorus compositions with improved color
Inventor: STOWELL JEFFREY KENT
IPC: C07F9/09
Filed: 2000-07-04
Abstract: An aryl group containing phosphite, such as triphenyl phosphite, can be adde d to a reaction mixture comprising an organophosphorus compound, phosphorus pentoxide and an alkylene oxide, optionally in the presence of a reagent for  the incorporation of hydroxy functionality in the final product. The aryl group containing phosphite is employed to improve the color characteristics of the resulting oligomeric organophosphorus composition.
Patent CA-2386009-A1 (CA)
Inventor: ANGELIDIS JEAN
IPC: A61L9/01
Filed: 2001-07-31
Abstract: The invention concerns a method for bactericidal, fungicidal, virucidal and insecticidal treatment of ambient air. Said method consists in circulating air (1) through a permeable container wherein is placed at least a treating agent. The invention is characterised in that the treating agent (2) is used as bactericide, fungicide, virucide and insecticide additionally to mechanical air filtering, and is distributed uniformly inside the container (4) so as to prevent micro-organisms from developing on the container itself. The invention is applicable to calorie-exchanging and air-recycling installations and appliances, and to coating elements of building surfaces.
Patent CA-2387392-A1 (CA)
Inventor: HAZELL STUART LLOYD
IPC: A61K48/00
Filed: 2000-10-13
Abstract: An isolated polypeptide and immunogenic fragments thereof are described together with their variants and derivatives as novel immunogenic agents for  treating or preventing Helicobacter infection in a mammalian host. The polypeptide comprises a C-terminal portion of a Helicobacter catalase, which  portion lacks significant amino acid sequence identity with human catalase, wherein the polypeptide is other than full-length Helicobacter catalase.</SD OAB>
Patent CA-2387410-A1 (CA)
Inventor: RANFORD ALAN
IPC: A61M5/178
Filed: 2000-04-12
Abstract: L'invention concerne un dispositif de thoracentèse (10) pourvu d'un mécanisme d'indication hypersensible (16, 18) à double ressort servant à avertir l'utilisateur que l'extrémité distale à tête arrondie (32) du dispositif de thoracentèse (10) est entrée d'une manière ou d'une autre en contact avec des organes internes du corps une fois que le dispositif (10) a été inséré dans le corps du patient. Le dispositif de thoracentèse (10) selon l'invention comprend une poignée et une aiguille externe (30) présentant un conduit longitudinal (34) en communication fluidique avec une cavité (50) définie à l'intérieur de la poignée (11). Une aiguille interne à ressort (28) est logée coulissante à l'intérieur du conduit (34), la partie proximale de l'aiguille interne (28) coopérant de manière fonctionnelle avec un grand ressort (22) qui imprime une force de rappel distale suffisante pour étendre complètement l'extrémité à tête arrondie (32) de l'aiguille interne (28) au-delà de l'extrémité distale pointue (54) de l'aiguille externe (30).
Patent CA-2387864-A1 (CA)
Inventor: GETZENBERG ROBERT H
IPC: A61K48/00
Filed: 2000-10-16
Abstract: L'invention concerne des protéines de matrice nucléaire (PMN) qui sont caractérisées par une expression définie dans le tissu, en particulier dans le tissu de la prostate. Ces PMN sont des marqueurs utiles pour le diagnostic et la surveillance du degré de malignité d'une cellule, et pour le traitement des maladies à prolifération cellulaire associées aux PMN. L'invention concerne également des polypeptides sensiblement purifiés et des séquences nucléotidiques codant pour ces PMN.
Patent CA-2387998-A1 (CA)
Title: Highly time resolved impedance spectroscopy
Inventor: SACKMANN ERICH
IPC: G01N27/416
Filed: 2000-09-29
Abstract: A highly time resolved impedance spectroscopy that enhances the measurement of the dynamics of non-stationary systems with enhanced time resolution. The highly time resolved impedance spectroscopy includes an optimized, frequency  rich a.c., or transient, voltage signal is used as the perturbation signal, non-stationary time to frequency transformation algorithms are used when processing the measured time signals of the voltage and current to determine  impedance spectra which are localized in time; and the system-charachterizin g quantities are determined from the impedance spectra using equivalent circui t fitting in a time-resolution-optimized form.
Patent CA-2392078-A1 (CA)
Title: Hand held induction tool
Inventor: KUECKER CHARLES A
IPC: H05B6/02
Filed: 2000-11-02
Abstract: An apparatus and system for using magnetic fields to heat magnetically susceptible materials within and/or adjacent to adhesives, resins, or composites so as to reversibly or irreversibly bond, bind, or fasten opaque or non-opaque solid materials to one another. The system makes use of the effect that alternating magnetic fields induce eddy currents and generate heat within susceptors, and the effect that alternating magnetic fields additionally induce magnetic hysteresis that occurs in magnetic materials and thereby generate heat. An induction heating tool is used to emit the magnetic field at its work coil, and an electronic controller measures the energy being used by a power converter that generates the alternating current driving the work coil which creates the magnetic field. The distance between the susceptor and work coil is repeatedly analyzed based upon the power converter's input energy, and the work coil is driven at a repeatedly corrected power level during the heating cycle. Once a sufficient accumulated energy has been delivered to the susceptor, the magnetic field is turned off automatically by the tool, thus preventing overheating of the susceptor.
Patent CA-2392740-A1 (CA)
Inventor: RUBEN STEVEN M
IPC: A61K48/00
Filed: 2000-12-07
Abstract: L'invention concerne de nouveaux polypeptides humains de type IL-6 et des acides nucléiques isolés contenant les régions codantes des gènes codant pour ces polypeptides. L'invention concerne également des vecteurs, des cellules hôtes et des procédés recombinants permettant de produire des polypeptides humains de type IL-6.
Patent CA-2393260-A1 (CA)
Title: Asymmetric alternating prism arrays
Inventor: FUTHEY JOHN A
IPC: F21V8/00
Filed: 2000-11-29
Abstract: A luminaire (8) is provided which includes a light source (14), a light guide (10) that receives light radiating from the light source (14), and a plurality of prisms (12) adjacent the light guide (10) that redirect the light guide (10) substantially perpendicular to a longitudinal axis of the light guide (10). The prism angles, in one embodiment, are 25~-90~-65~. The fine pitch prism arrays preferably alternate or flip-flop every few millimeters, for example, one to two millimeters to create the visual appearance of bright and dark bands which cause the structure to appear like macro prisms.
Patent CA-2393358-A1 (CA)
Inventor: SUZUKI TOSHIYUKI
IPC: C07D213/42
Filed: 2000-12-13
Abstract: L'invention concerne des dérivés hétérocycliques représentés par la formule générale (1) ou des sels desdits dérivés, lesquels sont utilisés comme médicaments. Dans ladite formule, A représente un hétéroaryle ou un oxyde dudit hétéroaryle; B désigne éthylène; D représente un phénylène éventuellement substitué; et E désigne un groupe représenté par la formule générale (2) [où G représente un phényle éventuellement substitué; et R désigne un hétéroaryle, un hétéroarylméthyle ou un groupe représenté par la formule générale (3): (dans laquelle n désigne un entier compris entre 1 et 5; et R?5¿ et R?6¿ représentent chacun indépendamment hydrogène, C¿1-6?alkyle, hydroxyalkyle ou aminoalkyle, ou alors R?5¿ et R?6¿ peuvent représenter, avec l'atome d'azote qui leur est adjacent (-NR?5¿R?6¿), un groupe cycloamino à 5-7 éléments)].
Patent CA-2397347-A1 (CA)
Title: Factor vii or viia-like molecules
Inventor: PEDERSEN ANDERS HJELHOLT
IPC: A61K47/48
Filed: 2001-02-12
Abstract: The present invention relates to novel factor VII (FVII) or Factor VIIa (FVIIa) polypeptide conjugates, to their preparation and use in therapy, in particular for the treatment of a variety of coagulation-related disorders. These novel polypeptide conjugates comprise at least one non-polypeptide moiety covalently attached to a polypeptide, wherein the amino acid sequence  of the polypeptide differs from that of wild-type FVII or FVIIa in that at least one amino acid residue comprising an attachment group for said non- polypeptide moiety has been introduced or removed. The conjugates of the present invention have one or more improved properties as compared to commercially available rFVIIa, including increased functional in vivo half- life and/or increased plasma half-life, and/or increased bioavailability and/or reduced sensitivity to proteolytic degradation.
Patent CA-2403376-A1 (CA)
Inventor: HIRANO HIROYUKI
IPC: B29C45/18
Filed: 2002-01-09
Abstract: Cette invention se rapporte à un dispositif de formation capable de produire une opération d'imprégnation au gaz, tout en maintenant la longueur totale d'une vis à une dimension telle que le cylindre d'une machine de formage existante peut être utilisée pour la vis sans aucune modification. A cet effet, ce dispositif comprend la vis (3) utilisée dans l'opération d'imprégnation au gaz, cette vis comprenant une partie en résine moulée (C) placée sur son côté amont et servant à amener la résine à l'état fondu, une partie non remplie de résine moulée (E) se prolongeant jusqu'au côté aval de la partie en résine moulée (C) et servant à réduire la pression de la résine jusqu'à un niveau inférieur à la pression du gaz inerte au niveau d'un orifice d'amenée de gaz (5), et une partie d'imprégnation au gaz (D) se prolongeant jusqu'au côté aval de la partie non remplie de résine moulée (E) et servant à imprégner la résine moulée du gaz inerte amené jusqu'à elle.
Patent CA-2406672-A1 (CA)
Inventor: GILAD SHLOMIT
IPC: C12Q1/68
Filed: 2001-03-16
Abstract: According to the present invention, there is provided a method of testing a subject to determine if the subject has a predisposition for developing primary or bilateral breast cancer which includes the steps of detecting a mutation in the open reading frame of the ATM gene (SEQ.ID.NO: 1) in a cDNA  sample from the subject, in a genomic DNA sample from the subject, which mutation is selected from the group consisting of the mutations set forth in Table 4 and Table 5; or detecting a mutation in the mRNA corresponding to the open reading frame of the ATM gene (SEG.ID.NO: 1) in a mRNA sample from the subject, which mutation is selected from the group consisting essentially of RNA complementary to the mutations set forth in Table 4 and Table 5, wherein the presence of such a mutation indicates that the subject has a predisposition for developing primary or bilateral breast cancer. Also provided is an isolated cDNA having a nucleotide sequence which differs from the sequence set forth in SEQ.ID.NO: 1 by including a mutation selected from the group consisting essentially of mutations in position 378 T->A, position 3383 A->G, position 1636 C->G, position 2614 C->T, position 6437 G->C, position 2932 T->C, position 2289 T->A, position 6096 A->T, position 6176 C->T, position 6919 C->T, position 3925 G->A, position 6067 G->A, position 2119 T->C, position 1810 C->T, and position 4388 T->G. A marker for determining a predisposition for breast cancer is also provided.
Patent CA-2407138-A1 (CA)
Inventor: LEE AARON
IPC: B62B3/00
Filed: 2001-05-14
Abstract: Cette invention concerne un véhicule avec une roulette (12) comportant un système de direction débrayage permettant de changer rapidement de mode de direction : par l'occupant ou par une personne extérieure au véhicule. Le véhicule comprend un châssis (caisse) (20), la roulette et un mécanisme de direction (22, 24, 34) monté sur le châssis. Un dispositif de débrayage (32) est implanté entre le mécanisme de direction et la roulette. Lorsque ce dispositif rend le mécanisme de direction solidaire de la poulie, le véhicule peut être conduit par son occupant du fait que le mécanisme de direction et la roulette tournent d'un bloc. Par contre, lorsque le dispositif de débrayage désolidarise le mécanisme de direction de la roulette, cette dernière peut pivoter librement (360·) sur son axe vertical de telle sorte que le véhicule peut être poussé ou tiré dans n'importe quelle direction par une personne extérieure. Le véhicule peut être une poussette, un véhicule jouet, un scooter, une chaise roulante, un chariot, une servante, etc. et peut comporter plusieurs roulettes.
Patent CA-2407660-A1 (CA)
Inventor: VAN DER WEIJDE DAMMES HANS
IPC: C25D5/08
Filed: 2001-04-26
Abstract: Method for the elctrolytic coating of a metal strip, in which the strip forms a cathode and is moved in its longitudinal direction relative to an anode, an electrolyte flowing at least between the strip and the anode, characterized in that the flow of the electrolyte is influenced by holding a body between the strip and the anode.
Patent CA-2411183-A1 (CA)
Inventor: AUBEE NORMAN DORIEN JOSEPH
IPC: C08L23/06
Filed: 2002-11-05
Abstract: Novel polyethylene copolymer compositions prepared with a homogeneous catalyst system are characterized by having a unique high molecular weight, low comonomer (high density) fraction. These heterogeneous/homogeneous compositions may be prepared using a solution polymerization process in which the polymerization reactor contains a gradient in temperature, catalyst concentration or monomer concentration. The heterogeneous/homogeneous compositions of this invention are easily processed into films having excellent tear strengths and low hexane extractables.