baber/WOPTO huggingface dataset:
Patent DE-69513846-D1 (DE)
Inventor: VAN DAELE GEORGES
IPC: A61P1/06
Filed: 1995-09-19
Granted: 2000-01-13
Abstract: The present invention is concerned with novel benzoate derivatives having formula (I), the N-oxide forms, the salts and the stereochemically isomeric forms thereof, wherein: R<1> is halo or C1-6alkylsulfonylamino; A represents a bivalent radical of formula -CH2-CH2- (a), -CH2-CH2-CH2- (b), -CH=CH- (c), in the radicals (a), (b) and (c) one or two hydrogen atoms may be replaced by a C1-6alkyl; R<2> is hydrogen or C1-6alkyloxy; L is a radical of formula: -Alk-R<4> (d), -Alk-O-R<5> (e), -Alk-NR<6>R<7> (f), Alk is C1-12alkanediyl; R<4> is hydrogen; cyano; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; C3-7cycloalkyl; C1-6alkylsulfinyl; C1-6alkylsulfonyl; phenyl or phenyl substituted with halo, C1-6alkyl or C1-6alkyloxy; tetrahydrofuran; dioxolane; dioxolane substituted with C1-6alkyl; dioxane; dioxane substituted with C1-6alkyl; pyridine; pyridine substituted with halo or C1-6alkyl; pyridazine; pyridazine substituted with one or two substituents selected from halo, C1-6alkyl, hydroxy or an optionally substituted benzimidazolone or an optionally substituted imidazolone; R<5> is hydrogen; C1-6alkyl; hydroxyC1-6alkyl; C1-6alkylcarbonyl; phenyl or phenyl substituted with up to three substituents selected from halo, C1-6alkyl, C1-6alkyloxy; R<6> is hydrogen or C1-6alkyl; R<7> is hydrogen; C1-6alkyl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; pyridazine; pyridazine substituted with one or two substituents selected from halo, C1-6alkyl, hydroxy; pyrazine; pyrazine substituted with one or two substituents selected from halo, C1-6alkyl, hydroxy. Pharmaceutical compositions comprising said compounds, processes for preparing compounds and compositions as well as the use as a medicine, in particular for the treatment of gastrointestinal disorders involving a decreased colon motility are described.
Patent DE-69516811-D1 (DE)
Inventor: BODART VINCENT
IPC: C08F265/04
Filed: 1995-11-15
Granted: 2000-06-15
Abstract: Graft copolymers of vinyl chloride onto a mixt. of lightly crosslinked polybutyl acrylate and ethylene/vinyl acetate copolymer (EVA), in which the graft copolymer contains a total of 3-10 (4-8) wt.% of the mixt. of lightly crosslinked polybutyl acrylate and EVA and the total content of EVA is less than 2 wt.%.
Patent DE-69518726-D1 (DE)
Inventor: ANTONSON IZIDOR
IPC: A61C8/00
Filed: 1995-07-03
Granted: 2000-10-12
Abstract: PCT No. PCT/SE95/00823 Sec. 371 Date Jun. 3, 1996 Sec. 102(e) Date Jun. 3, 1996 PCT Filed Jul. 3, 1995 PCT Pub. No. WO96/01083 PCT Pub. Date Jan. 18, 1996An elongate supporting part in a replacement construction and a method of production thereof, the replacement construction is intended to be secured in the human body in implants with unique longitudinal courses by using at least one working model in which the longitudinal courses and connection surfaces of the implants are represented by representation members. The method comprising the steps of generating an electrical representation of the outer shape of the working model and providing this information to computer equipment. The computer equipment performs calculations in order to establish an outer shape for the supporting part and generates machining information based on this outer shape which represents the shape of the supporting part. This information is provided to a machining device which machines a blank and an electro erosion tool is created by providing electrodes in a working model at positions of the representation members. The electrodes are arranged in the same longitudinal direction as the representation members. The electro erosion tool is used to create a recess in the blank for contact members whereby the blank can be anchored on the implants. The recess and the contact members have a longitudinal axis which coincide with the axis of the implants.
Patent DE-69523007-D1 (DE)
Inventor: GRENSING FRITZ C
IPC: C22C1/04
Filed: 1995-02-22
Granted: 2001-11-08
Abstract: Disclosed is a practical aluminum-based alloy containing 1 to 99 weight percent beryllium and improved methods for the investment casting of net shape aluminum-beryllium alloy parts.
Patent DE-69523741-D1 (DE)
Inventor: BUSH DEAN
IPC: A61K8/30
Filed: 1995-02-27
Granted: 2001-12-13
Abstract: The subject invention relates to pharmaceutical compositions comprising a safe and effective amount of a compound having the structure:   <IMAGE>   wherein n is 3 or 4; each R is independently alkyl or alkoxy; and R' is C1C20 alkyl; and a pharmaceutically-acceptable topical carrier. The subject invention also relates to methods for preventing damage to skin, without markedly sensitizing the skin, by topically applying a safe and effective amount of such compounds to the skin.
Patent DE-69524413-D1 (DE)
Inventor: LUPPINO COSMO
IPC: F16K31/36
Filed: 1995-05-31
Granted: 2002-01-17
Abstract: PCT No. PCT/AU95/00325 Sec. 371 Date Nov. 26, 1996 Sec. 102(e) Date Nov. 26, 1996 PCT Filed May 31, 1995 PCT Pub. No. WO95/33155 PCT Pub. Date Dec. 7, 1995A soft closing liquid valve of the pilot control type including an inlet chamber, an outlet chamber, a third pilot chamber, a first conduit for liquid communication between the inlet chamber and the third chamber and a second conduit for fluid communication between the third chamber and the outlet chamber whereby the liquid flow rate through the first conduit is reduced by the conduit including a tortuous path means so that the flow rate into the third chamber is substantially reduced and when the second conduit is closed causes the third chamber to fill at a slower rate than in conventional pilot controlled valves, the resultant slow rate of change of pressure causing a slow closure of the flow path between the inlet and outlet chambers by a diaphragm thus minimizing water hammer. The first conduit may include a third conduit and a fourth chamber in liquid communication with the tortuous path, the third conduit acting as a filter means for the tortuous path by selecting its cross-sectional size to be smaller than that of the tortuous path. In another embodiment, the first conduit is formed through and using the peripheral bead of the diaphragm.
Patent DE-69534029-D1 (DE)
Inventor: FANG GERARD
IPC: A61K31/00
Filed: 1995-05-02
Granted: 2005-03-31
Abstract: The present invention relates to a method for preparing intermediates useful in the preparation of camptothecin and camptothecin-like compounds and to the intermediates used in this preparation. In particular, the invention provides a process for the preparation of a compound of formula II' <CHEM> wherein X is halogen, which comprises reacting a compound of formula III <CHEM>  with a compound of formula IX' <CHEM>
Patent DE-69534318-D1 (DE)
Inventor: PLATZ ROBERT M
IPC: C07K14/555
Filed: 1995-05-15
Granted: 2005-08-25
Abstract: According to the present invention, methods and compositions are provided for spray-dried, interferon-based dry powder compositions, particularly interferon-beta. The compositions are useful for treating conditions in humans that are responsive to treatment with interferons. In particular, the methods of the present invention rely on spray drying to produce stable, high-potency dry powder formulations of interferons, including but not limited to IFN-beta. Surprisingly, it has been found that IFN can be prepared in high potency, dry powder formulations by spray drying. Such dry powder formulations find particular utility in the pulmonary delivery of IFN.
Patent DE-69535155-D1 (DE)
Inventor: HORELLOU PHILIPPE
IPC: A61K35/76
Filed: 1995-03-23
Granted: 2006-09-21
Abstract: Recombinant adenoviruses comprising a heterologous DNA sequence coding for glial-derived neurotrophic growth factor (GDNF) are provided. The recombinant adenoviruses are useful in a method of expressing GDNF in a cell, wherein the cell is present in a mammal suffering from Parkinson's disease, comprising infecting said cell with a replication-defective recombinant adenovirus comprising a DNA sequence encoding GDNF operably linked to a promoter by administering the adenovirus into cells of the central nervous system. The recombinant adenoviruses of the invention are also useful in a method of treating Parkinson's disease comprising administering into cells of the central nervous system of a mammal suffering therefrom a replication defective recombinant adenovirus comprising ITRs, an encapsidation sequence and a DNA sequence encoding GDNF operably linked to a promoter, wherein the adenovirus E1 gene is non-functional and GDNF is expressed at a level that provides a therapeutic effect.
Patent DE-69600780-D1 (DE)
Inventor: LEBRETON LUC
IPC: C07C277/00
Filed: 1996-02-07
Granted: 1998-11-19
Abstract: PCT No. PCT/FR96/00203 Sec. 371 Date Oct. 10, 1996 Sec. 102(e) Date Oct. 10, 1996 PCT Filed Feb. 7, 1996 PCT Pub. No. WO96/24579 PCT Pub. Date Aug. 15, 1996The present invention relates to compounds selected from the group consisting of: (i) the compounds of the formula    <IMAGE>  (I)  in which: R is a hydrogen atom, a group OH, a group OCH3 or a group CH2OH, *C, in the case where R is not a hydrogen atom, is an asymmetric carbon atom of (R,S), (R) or (S) configuration, and **C is an asymmetric carbon atom of (R,S) or (R) configuration; and (ii) their addition salts. It further relates to the method of preparing these compounds, to their use in therapeutics and in the field of analysis, and to intermediates.
Patent DE-69605211-D1 (DE)
Title: Palette
Inventor: DIDERICH JOHANNES
IPC: B65D19/00
Filed: 1996-08-23
Granted: 1999-12-23
Abstract: A pallet comprising an upper cover plate (1), a lower cover plate (2) and columns (3) between the upper cover plate and the lower cover plate is described. According to the invention the upper cover plate (1) and the lower cover plate (2) are made of paper material and the columns (3) are made of material which can be rammed in the longitudinal direction of the columns and is formed by rolled up corrugated board, the ends of the columns (3) being arranged in holes in the upper cover plate (1) and the lower cover plate (2). Preferably the upper cover plate (1) and the lower cover plate (2) are made of honeycomb plates.
Patent DE-69607861-D1 (DE)
Inventor: SHARPE ERNEST
IPC: C10J3/30
Filed: 1996-10-25
Granted: 2000-05-25
Abstract: PCT No. PCT/GB96/02169 Sec. 371 Date Apr. 27, 1998 Sec. 102(e) Date Apr. 27, 1998 PCT Filed Oct. 25, 1996 PCT Pub. No. WO97/15641 PCT Pub. Date May 1, 1997A process for the production of heat energy from solid carbonaceous fuels is disclosed which comprises subjecting the carbonaceous fuel to substantially anaerobic pyrolysis in at least one first zone and thereafter transferring the char resulting from the pyrolysis to a second zone which is segregated from the first zone or zones. The char is subjected to gasification in the second zone by introduction of primary combustion air, optionally with steam and/or recycled exhaust gas. The off gases from the second zone and the pyrolysis gases from the first zone or zones are thereafter subjected to secondary combustion and the first zone or zones is heated by heat derived from the secondary combustion. Ash is removed from the bottom of the second zone.
Patent DE-69614146-D1 (DE)
Inventor: MONTE T
IPC: C07C45/60
Filed: 1996-12-10
Granted: 2001-08-30
Abstract: A process of preparing alkyl or aryl aldehydes using Grignard protected aldehydes and alkyl or benzyl halides is provided. The Grignard protected aldehyde is reacted with the halide in the presence of a copper catalyst and the product of that reaction is selectively deprotected by hydrolysis.
Patent DE-69614749-D1 (DE)
Inventor: MANNIO AARON
IPC: D06H7/00
Filed: 1996-04-15
Granted: 2001-10-04
Abstract: The invention concerns a web cutting device (10), which includes a cutter blade (11) and an actuator (12), which is fitted to act upon the cutter blade (11) so as to produce the cutting stroke. The actuator (12) consists of a number of cylinders (13) placed inside a container (17) or of a number of cylinders placed each of them in a container of its own, each of which cylinders includes a piston (14) and a piston rod (15), and said piston rods (15) have been attached to the cutter blade (11) with a certain spacing. <IMAGE>
Patent DE-69623532-D1 (DE)
Inventor: KOYANAGI TORU
IPC: C07C229/22
Filed: 1996-05-13
Granted: 2002-10-17
Abstract: A process for producing a 4-alkoxy-1,1,1-trifluoro-3-buten-2-one of the formula (III): CF3CO-CH=CH-OR<1> wherein R<1> is an alkyl group, which comprises reacting a halide of the formula (I): CF3COHal wherein Hal is a halogen atom, with a compound of the formula (II): CH2=CHOR<1> wherein R<1> is as defined above, in the presence of a base.
Patent DE-69633734-D1 (DE)
Inventor: BAKER R
IPC: C07D498/04
Filed: 1996-06-25
Granted: 2004-12-02
Abstract: Methods, compounds and compositions are provided for inhibiting the growth of pathogenic mycobacteria in vitro and of treatment of pathogenic bacterial infections, such as mycobacterial and clostridium infections, in vivo using bicyclic nitroimidazole compounds of the formula (II):    <IMAGE>  (II)  wherein R1 is hydrogen, halogen, loweralkyl, haloloweralkyl, cycloalkyl, heterocycle, substituted heterocycle and heterocyclicalkyl; X is oxygen, sulfur or NK2, where R2 is hydrogen, loweralkyl, aryl, cycloalkyl, heterocycle, substituted heterocycle, heterocyclicalkyl, COR3 or SO2R4CONR4R5, where R4 and R5 are independently selected from hydrogen, loweralkyl, aryl, alkylaryl, alkoxyalkyl, alkoxyaryl, alkoxyalkoxyaryl, alkylheterocycle, and alkoxyheterocycle; n is 1, 2 or 3; Y and Z are independently selected CH2, CO, CR4R5 or NR4, where R4 and R5 are as defined above; provided that when n is 2 or 3, the compounds of formula II can be additionally substituted as follows:    <IMAGE>  (IIa)   <IMAGE>  (IIb)  wherein R6, R7, R8 and R9 are independently selected from hydrogen, loweralkyl, aryl, alkylaryl, alkoxyalkyl, alkoxyaryl, alkoxyalkoxyaryl, alkylheterocycle, and alkoxyheterocycle; and the pharmaceutically acceptable salts thereof. The methods, compounds and compositons are particularly useful for inhibiting the growth of Mycobacterium tuberculosis and Clostridium difficile.
Patent DE-69635050-D1 (DE)
Inventor: JENSEN F
IPC: A61B19/00
Filed: 1996-06-05
Granted: 2005-09-15
Abstract: The invention is directed to manipulator assembly (2) for holding and manipulating a surgical instrument (14) in a telerobotic system. The manipulator assembly includes an instrument holder removably coupled to a drive assembly so that the holder can be sterilized. The assembly further includes a force sensing element (52) mounted distal to the holder and the drive assembly for detecting forces exerted on the surgical instrument and providing feedback to the surgeon. The invention is also directed to a system and method for releasably holding a surgical instrument (14). The system includes an instrument support for automatically locking mounting pins on the instrument within locking slots on the instrument holder to releasably couple the instrument to the holder. With a twist-lock motion, the surgeon can rapidly engage and disengage various instruments from the holder during a surgical procedure, such as open surgery, laparoscopy or thoracoscopy.
Patent DE-69638078-D1 (DE)
Inventor: ASHIKARI TOSHIHIKO
IPC: C07H21/04
Filed: 1996-02-16
Granted: 2009-12-31
Abstract: Proteins having an aromatic-acyltransferase activity; a gene system coding for the same; a process for producing the proteins using the gene system; and uses of the genes and the proteins. The genes and the proteins acylate plant pigments such as anthocyanin to thereby cause color tone changes, thus providing plants, particularly flowers, having colors that have not been inherent therein.
Patent DE-69705083-D1 (DE)
Inventor: OELTJEN SUSAN T
IPC: C09J177/00
Filed: 1997-03-14
Granted: 2001-07-12
Abstract: A method of bookbinding comprising the steps of a) applying a film comprising at least one hot melt polyamide at an application temperature of between about 175 DEG C and about 190 DEG C to the backbone of a book block said film having a tensile strength greater than about 400 psi and a Young's modulus of less than about 12,000 psi and b) covering said book block having said film of polyamide with a book cover having a portion thereof in substantially parallel relation to said film.
Patent DE-69705429-D1 (DE)
Inventor: BARONI MARCO
IPC: A61K31/445
Filed: 1997-12-12
Granted: 2001-08-02
Abstract: PCT No. PCT/FR97/02286 Sec. 371 Date Jul. 27, 1999 Sec. 102(e) Date Jul. 27, 1999 PCT Filed Dec. 12, 1997 PCT Pub. No. WO98/25903 PCT Pub. Date Jun. 18, 1998The invention relates to compounds of the formula in which: Y is -CH- or -N-; R1 is hydrogen, a halogen or a CF3, (C1-C4)alkyl or (C1-C4)alkoxy group; R2 is a methyl or ethyl group; R3 and R4 are each hydrogen or a (C1-C3)alkyl; and X is: (a) a (C1-C6)alkyl, a (C1-C6)alkoxy, a (C3-C7)carboxyalkyl, a (C1-C4)alkoxy-carbonyl(C1-C6)alkyl, a (C3-C7)carboxyalkoxy or a (C1-C4)alkoxycarbonyl-(C1-C6)alkoxy; (b) a radical selected from (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C3-C7)-cycloalkylmethyl, (C3-C7)cycloalkylamino and cyclohexenyl, it being possible for said radical to be substituted by a halogen, hydroxyl, (C1-C4)-alkoxy, carboxyl, (C1-C4)alkoxycarbonyl, amino or mono- or di-(C1-C4)-alkylamino; or (c) a group selected from a phenyl, phenoxy, phenylamino, N-(C1-C3)alkyl-phenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulfonyl, phenylsulfinyl and styryl, it being possible for said group to be monosubstituted or polysubstituted on the phenyl group by a halogen, CF3, (C1-C4)alkyl, (C1-C4)alkoxy, cyano, amino, mono- or di-(C1-C4)alkyl-amino, (C1-C4)acylamino, carboxyl, (C1-C4)alkoxycarbonyl, aminocarbonyl, mono- or di-(C1-C4)alkylaminocarbonyl, amino(C1-C4)alkyl, hydroxy(C1-C4)alkyl or halogeno(C1-C4)alkyl; to a method of preparing them and to the pharmaceutical compositions containing them. These compounds have neurotrophic and neuroprotective activity.
Patent DE-69709320-D1 (DE)
Inventor: HILTUNEN ELINA
IPC: C08K5/103
Filed: 1997-03-04
Granted: 2002-01-31
Abstract: PCT No. PCT/FI97/00143 Sec. 371 Date Feb. 1, 1999 Sec. 102(e) Date Feb. 1, 1999 PCT Filed Mar. 4, 1997 PCT Pub. No. WO97/32929 PCT Pub. Date Sep. 12, 1997The invention relates to polylactide films the mechanical properties of which, in particular bursting strength, elongation and tearing strength, have been improved by adding to the polymer certain plasticizers. These plasticizers are preferably glycerol esters.
Patent DE-69715173-D1 (DE)
Title: Bisarylcyclobutenderivate als cyclooxygenasehemmer
Inventor: DUBE DANIEL
IPC: C07D333/22
Filed: 1997-03-25
Granted: 2002-10-10
Abstract: The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
Patent DE-69721516-D1 (DE)
Inventor: RAGHOENATH DILIPKOEMAR
IPC: C12P19/62
Filed: 1997-02-07
Granted: 2003-06-05
Abstract: A process for the recovery of natamycin from a fermentation broth containing biomass and natamycin, which comprises: (a) disintegrating the biomass; and (b) separating the natamycin from the thus treated fermentation broth.
Patent DE-69721606-D1 (DE)
Inventor: MIMENZA LARRACOECHEA RAMON
IPC: E04B5/29
Filed: 1997-02-14
Granted: 2003-06-12
Abstract: The unidirectional flat concrete flooring construction system according to the improvement uses special structures for forming the mixed flat girders on-site, said special structures being based on an inverted "T" metal profile (1) to which are welded, through one of its ends, connectors (4) arranged in a slanting position in respect to the horizontal, being complemented by an upper horizontal hanger made of a corrugated round rod (7) to which are welded the other ends of the connectors (4), so that said structure complemented by the planking (10), the supporting pillars (9), the semi-resistant joists (11), the hollow bricks (14) and other structural elements is able to provide, by on-site laying of concrete, mixed flat girders with a stem and a concrete compression layer which allows for continuity of the girders. <IMAGE>
Patent DE-69723970-D1 (DE)
Inventor: FEISSEL SOPHIE
IPC: H04N1/32
Filed: 1997-04-25
Granted: 2003-09-11
Abstract: Telephone comprising a radio unit (2) which can receive and provide on two sides analog signals and digital data, a corrector unit (3), a data processing unit (100) comprising a rate adaptor (8) and a fax adaptor (9), input means (14), a control unit (7), the data processing unit (100) and additionally a fax data memory (1,1, 16), the control unit (7) being arranged to control at least one of the two emission and reception functions of said fax data.
Patent DE-69732228-D1 (DE)
Inventor: CHANTRY H
IPC: C12N15/54
Filed: 1997-11-25
Granted: 2005-02-17
Abstract: The present invention generally relates to a novel catalytic subunit of a lipid kinase designated p110 delta . Polynucleotides encoding p110 delta  and recombinant p110 delta  polypeptides are provided along with antibodies 2 p110 delta , assays for identifying inhibitors of p110 delta , and the like.
Patent DE-69733424-D1 (DE)
Inventor: VAUDENAY SERGE
IPC: G09C1/00
Filed: 1997-11-04
Granted: 2005-07-07
Abstract: Method for the cryptography of data recorded on a medium usable by a computing unit in which the computing unit processes an input information x using a key for supplying an information F(x) encoded by a function F. The function uses a decorrelation module Mk such that F(x)=[F'(Mk)](x), in which K is a random key and F' a cryptographic function. This Abstract is neither intended to define the invention disclosed in this specification nor intended to limit, in any manner, the scope of the invention.
Patent DE-69735767-D1 (DE)
Title: Cellulasevarianten
Inventor: ANDERSEN Vilbour
IPC: D06L4/40
Filed: 1997-09-17
Granted: 2006-06-01
Abstract: A method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of: 
a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from  Humicola insolens  known from Protein Data Bank entry 4ENG; 
b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; 
c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5Å; 
d. identifying surface-exposed amino acid residues of the enzyme; 
e. identifying all charged or potentially charged amino acid residue positions of the enzyme; 
f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; 
g. carrying out the substition, deletion or insertion by using conventional protein engineering techniques; and cellulase variants obtained by the method.
Patent DE-69736249-D1 (DE)
Inventor: HORROBIN DAVID FREDERICK
IPC: A61K31/714
Filed: 1997-08-27
Granted: 2006-08-10
Abstract: A method of treating pain by the co-administration of an antidepressant together with one or more precursors or inducers of neurotransmitters, particularly amino acids selected from L-phenylalanine, L-tyrosine, L-tryptophan and L-DOPA.