Patent SG-11201809822S-A (SG)
Title: Atropine-containing aqueous composition
Inventor: TAN DONALD
IPC: A61K47/38
Filed: 2017-05-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111011101111111111111111111111111111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\"1 WO 2017/204262 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, A61K 31/46 (2006.01) A61K 47/12 (2006.01) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, A61K 9/08 (2006.01) A61K 47/18 (2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, A61K 47/02 (2006.01) A61K 47/26 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, A61K 47/10 (2006.01) A61K 47/38 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/JP2017/019423 kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 24 May 2017 (24.05.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). 10201604200P 25 May 2016 (25.05.2016) SG Published: (71) Applicants: SINGAPORE HEALTH SERVICES PTE — LTD [SG/SG]; 31 Third Hospital Avenue, #03-03 Bowyer with international search report (Art. 21(3)) Block C, Singapore, 168753 (SG). NANYANG TECH- NOLOGICAL UNIVERSITY [SG/SG]; 50 Nanyang Av- _ enue, Singapore, 639798 (SG). SANTEN PHARMA- CEUTICAL CO., LTD. [JP/JP]; 9-19, Shimoshinjo 3- chome, Higashiyodogawa-ku, Osaka-shi, Osaka, 5338651 — (JP). = Inventors: TAN, Donald; c/o Singapore Eye Research (72) — = Institute, 11 Third Hospital Ave, 168751 (SG). BEUER- MAN, Roger; c/o Singapore Eye Research Institute, 11 _ Third Hospital Ave, 168751 (SG). ASADA, Hiroyuki; c/ = o SANTEN PHARMACEUTICAL CO., LTD., 8916-16, Takayama-cho, Ikoma-shi, Nara, 6300101 (JP). TAKA- HASHI, Kyohei; c/o SANTEN PHARMACEUTICAL = CO., LTD., 8916-16, Takayama-cho, Ikoma-shi, Nara, = 6300101 (JP). SAKANAKA, Koji; c/o SANTEN PHAR- MACEUTICAL CO., LTD., 8916-16, Takayama-cho, Iko- = = ma-shi, Nara, 6300101 (JP). MORIMOTO, Takashi; c/ = o SANTEN PHARMACEUTICAL CO., LTD., 8916-16, = Takayama-cho, Ikoma-shi, Nara, 6300101 (JP). FU- JISAWA, Toyomi; c/o SANTEN PHARMACEUTICAL = CO., LTD., 8916-16, Takayama-cho, Ikoma-shi, Nara, = 6300101 (JP). = Agent: SAMEJIMA, Mutsumi et al.; AOYAMA & (74) = — PARTNERS, Umeda Hankyu Bldg. Office Tower, 8-1, = Kakuda-cho, Kita-ku, Osaka-shi, Osaka, 5300017 (JP). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (81) — 1-1 N ei iv 0 el (54) Title: ATROPINE-CONTAINING AQUEOUS COMPOSITION IN ,-1 (57) : Disclosed herein is an aqueous composition comprising 0.001 - 0.1 % (w/v) atropine or a salt thereof, a water-soluble 0 polymer, and buffer (I), which is at a pH range of 6 or lower, wherein the buffer (I) is at least one selected from the group consisting of \" a phosphate buffer, an aminocarboxylate buffer, a carbonate buffer, an acetate buffer, a tartrate buffer, a borate buffer, and trometamol.