Patent SG-11201804951S-A (SG)
Title: Use of tryptophan derivatives for protein formulations
Inventor: SHARMA VIKAS
IPC: A61K39/00
Filed: 2016-12-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization M11111 0 HEIN MEM 0 1E3010 11111 001101 1111111101111 III 11 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/117304 Al 6 July 2017 (06.07.2017) WI P0 I P CT (51) International Patent Classification: (US). SALISBURY, Cleo; c/o Genentech, Inc., 1 DNA A61K 9/08 (2006.01) A61K 38/00 (2006.01) Way, South San Francisco, CA 94080 (US). A61K 47/18 (2017.01) A61K 39/00 (2006.01) (74) Agents: AHN, Sejin et al.; Morrison & Foerster LLP, 755 (21) International Application Number: Page Mill Road, Palo Alto, CA 94304-1018 (US). PCT/US2016/069039 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 28 December 2016 (28.12.2016) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/273,273 30 December 2015 (30.12.2015) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 62/321,636 12 April 2016 (12.04.2016) US RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (71) Applicant (for all designated States except AL, AT, BA, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, ZA, ZM, ZW. GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, (84) Designated States (unless otherwise indicated, for every NO, PL, PT, RO, RS, SE, SI, SK, SM, TR): GENENTECH, kind of regional protection available): ARIPO (BW, GH, INC. [US/US]; 1 DNA Way, South San Francisco, CA GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 94080-4990 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Applicant (for AL, AT, BA, BE, BG, CH, CN, CY, CZ, DE, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SK SM, TR only): F. HOFFMANN-LA ROCHE AG SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, , [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). GW, KM, ML, MR, NE, SN, TD, TG). (71) Inventors: SHARMA, Vikas; c/o Genentech, Inc., 1 DNA Published: (72) Way, South San Francisco, CA 94080 (US). LEISKE, — with international search report (Art. 21(3)) Danielle; c/o Genentech, Inc., 1 DNA Way, South San before the expiration of the time limit for amending the Francisco, CA 94080 (US). HAMBURG, Lydia; c/o Gen- claims and to be republished in the event of receipt of entech, Inc., 1 DNA Way, South San Francisco, CA 94080 amendments (Rule 48.2(h)) Il 7r © M IN 11 11 IN 1-1 (54) Title: USE OF TRYPTOPHAN DERIVATIVES FOR PROTEIN FORMULATIONS © ei (57) : The invention provides methods and formulations comprising a protein comprising solvent accessible amino acid en. ) residues susceptible to oxidation wherein N-acetyl tryptophan (NAT) is used to prevent oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. Methods to measure degradation of NAT in protein formulations are also provided.