baber/WOPTO huggingface dataset:
Patent IL-76131-A0 (IL)
Title: Production of asymmetric hydantoins
IPC: C07D491/107
Filed: 1985-08-19
Abstract: An improved process for preparing (4S)-6-fluoro-spiro-[chroman-4,4 min -imidazolidine]-2 min ,5 min -dione (sorbinil) or its (2R)-methyl derivative (2-methylsorbinil) is disclosed herein, starting from p-fluorophenol in each instance. The final products obtained have known pharmaceutical value as agents for the control of certain chronic diabetic complications. Key steps concerned with the process involve converting p-fluorophenol into the appropriate  beta -(4-fluorophenoxy)-alkane halide, followed by amidoalkylation with N-benzoyl or N-(lower alkanoyl)- alpha -hydroxyglycine to form an intermediate 2-amidoalkylated derivative thereof, and then dehydration and spiroalkylation of said intermediate by treatment with a dehydrating agent and a base to yield a spiroalkylated azlactone compound. The latter compound is then subsequently converted to the known 4-amino-6-fluorochroman-4-carboxylic acid or the novel (2R-methyl derivative thereof, both in the form of their hydrohalide acid addition salts, by employing acid hydrolysis and the intermediate spiro-amino acid hydrohalide salt is thereafter converted to the corresponding methyl or ethyl ester and resolved with  alpha -chymotrypsin to afford the desired (S)-methyl or (S)-ethyl ester. Treatment of either of these latter two esters with an alkali metal cyanate in an acid medium then effects conversion of same to the desired spiro-hydantoin ring compound. Alternatively, the spiro-amino acid hydrohalide salt can also be converted to the desired spiro-hydantoin ring compound in a known manner, involving a sequence of three reaction steps. The spiroalkylated azlactone compound of the instant invention, as well as the methyl and ethyl esters mentioned above, are themselves novel compounds and are valuable as synthetic intermediates in the process of this invention.
Patent IL-76245-A0 (IL)
Title: Pharmaceutical composition comprising a 2-hydroxy-n,n,n-trimethyl-ethanaminium salt of 3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione
IPC: A61K47/00
Filed: 1985-08-29
Abstract: An aqueous injection solution contains 1-25% by weight of 2-hydroxy-N,N,N-trimethyl-ethanaminium salt of 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1) and, based on this salt, 5-8% by weight of propionic acid.
Patent IL-78069-A0 (IL)
Title: Wavelength switched passive interferometric sensor system
IPC: G01D21/00
Filed: 1986-03-06
Abstract: @ This invention includes a fiber optic interferometer having a reference arm isolated from a physical parameter being monitored and a sensing arm exposed to the physical parameter being monitored. The sensing arm produces changes in the relative phase of the optical signals propagating in the sensing and reference arms in response to changes in the physical parameter. The sensing and reference signals are combined to produce an interference pattern after the sensing signal has been exposed to the physical parameter being monitored. A frequency shifter changes the frequency of the optical signal input to the interferometer, which produces interference signals for the two frequencies. The optical path difference of the sensing and reference arms for the two frequencies produces phase changes that are in quadrature, which permits the interference signal for one frequency to be expressed as a function of the cosine of the phase change and the interference signal forthe other frequency to be expressed as a function of the sine of the phase change. A demodulation algorithm uses data from the two interference signals to calculate either the tangent or cotangent of the phase angle to determine the phase change in the sensing signal caused by changes in the parameter.
Patent IL-79967-A0 (IL)
Title: Method of producing polymers and copolymers of amido-sulfonic acid containing monomers and salts thereof
IPC: C08F20/52
Filed: 1986-09-08
Abstract: A fluid loss agent comprising homopolymers or copolymers from amido-sulfonic acid or salt containing monomers obtainable in the presence of high energy mechanical mixing utilizing a final stage polymerisation temperature of from about 93 DEG C (200 DEG F) to below the degradation temperature of the monomer.
Patent IL-94361-A0 (IL)
Title: Polypeptides,recombinant dna molecules and method of producing a human hemoglobin like protein
IPC: G01N33/53
Filed: 1990-05-10
Abstract: A method of producing a hemoglobin-like protein wherein an alpha globin-like polypeptide and a beta globin-like polypeptide are each expressed in transformed non-erythrocyte cells such as bacterial or yeast cells, the method comprising expressing the alpha and beta globin-like polypeptide in the same cell in such manner that the alpha and beta globin-like polypeptides are assembled and combined with heme so as to intracellularly produce a biologically functional hemoglobin-like protein in soluble, recoverable form. <IMAGE>
Patent IL-99828-A0 (IL)
Title: Plasmids for the production of transgenic plants,plant cells and plants produced thereby
IPC: C12N15/55
Filed: 1991-10-23
Abstract: Plasmids that comprise a DNA sequence coding for a protein that modifies the metabolism of soluble sugars, for example, an inorganic pyrophosphatase agent and plant cells comprising those plasmids, for the production of transgenic plants that are modified in habit and yield are described, the plants being modified in habit by the transfer and the expression of genes that intervene in sugar metabolism or sugar distribution inside a plant.
Patent IL-99934-A0 (IL)
Title: Detachable chair back
IPC: A47C7/42
Filed: 1991-11-01
Abstract: An improved locking mechanism for detachably securing a seat back (18) to a chair frame is disclosed. The improved locking mechanism includes a pair of slide brackets (54) secured to opposite sides of the seat back (18). Linkages (20) supported from the chair frame are provided for receiving the slide brackets (54) thereon for supporting the seat back (18) on the chair frame in a predetermined orientation relative to the seat member. A moveable locking arm (72) is supported from the slide brackets (54) and includes an offset arcuate cam surface (75) which is adapted to engage an arcuate notch (76) formed on the linkage (20) when the locking arm (72) is moved to a locked position. The mating engagement of the arcuate offset cam surface (75) within the arcuate notch (76) generates a line-of-contact therebetween which inhibits relative movement between the slide brackets (54) and the upstanding links (20) for rigidly securing seat member to the chair frame. An alternative embodiment discloses a modified link member which is adapted to create an interference engagement with the slide bracket (54) to augment the locking action of the arcuate cam surface (75) within the arcuate notch (76). <IMAGE>
Patent AU-PQ744500-A0 (AU)
Title: Biomass burner
IPC: F23G5/16
Filed: 2000-05-11
Abstract: A burner comprising a fuel reservoir, a primary combustion zone located at the lower end of the fuel reservoir, a secondary combustion zone located underneath the primary combustion zone, a passage providing communication between the primary and secondary combustion zones, a flue for discharging products of combustion from the secondary combustion zone, the primary combustion zone having a peripheral wall incorporating air hole means to provide combustion air to the primary combustion zone, wherein the cross-sectional area of the air hole means is substantially equal to the combined minimum cross-sectional area of the passage and the minimum cross?sectional flow area of the flue.
Patent FI-20045102-A0 (FI)
Inventor: KARTTUNEN HEIKKI
IPC: D21F3/10
Filed: 2004-03-25
Abstract: The invention relates to a grooved forming roll, which includes a rotably supported shell (20) comprising circular openings (21) arranged to be opened at least on the outer surface of the shell (20). In connection with each opening (21), formed on the outer surface there is a circular groove (22), which is arranged concentrically relative to the corresponding opening (21). In addition, on the outer surface a portion of the formed circular openings (22) extends to each opening (21) from each adjacent opening (21). The outer radius (r) of the circular groove (22) is arranged such that the number of necks (24), delimited by the adjacent openings (21) and their circular grooves (22) on the shell outer surface within the area of one circular groove (22), is greater than the number of the adjacent openings (21) of the corresponding opening (21). <IMAGE>
Patent FI-20075258-A0 (FI)
Inventor: MARJAMAEKI ANNE
IPC: C12N/
Filed: 2007-04-17
Abstract: The present invention relates to a method for identifying responders to a blockade of integrin receptors, as well as to a method for determining responsiveness to a treatment involving with said blockade in a patient in need of such treatment. Furthermore, the present invention relates to a kit for use in said methods.
Patent FI-20105480-A0 (FI)
Inventor: LOKKINEN MIKA
IPC: F16L/
Filed: 2010-05-04
Abstract: A method for preparing a resizing sleeve for lining a joining point in a pipe assembly having pipes of thicker and thinner diameter. The method includes stretching the resizing sleeve in diameter to the size of the thicker pipe in diameter of the pipe assembly, installing an installation hat according to the thicker pipe in diameter of the pipe assembly by airtightly gluing it onto the stretched resizing sleeve, and returning the resizing sleeve to the size of the thinner pipe in diameter of the pipe assembly to be lined. A suitable tool for implementing the method is also disclosed.
Patent FI-20115218-A0 (FI)
Inventor: IMMONEN KIRSI
IPC: C08L/
Filed: 2011-03-03
Abstract: The present invention concerns a process for manufacturing a thermoformable plasticized composite containing cellulose fiber and polylactide by blending the dry cellulose fiber and a compatibilizer in a compactor into pellets, and subsequently reacting the reactive compatibilizer and the mixture of cellulose fiber and polylactide by compounding. The invention also concerns a composite manufactured using said process, as well as further processed products.
Patent IL-100098-A0 (IL)
Title: 1,2,3,6-tetrahydropyridine derivatives,their preparation and pharmaceutical compositions containing them
IPC: C07D211/70
Filed: 1991-11-20
Abstract: The present invention relates to novel 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) <CHEM>  - wherein  R stands for hydrogen or an alkyl group, X stands for an unsubstituted phenyl or benzyl group or for a phenyl or benzyl group substituted with a halogen atom,  Y stands for hydrogen or halogen or a trifluoro-methyl group -  as well as enantiomers acid addition salts thereof. The invention further extends to pharmaceutical compositions containing said compounds as active ingredient mainly for improving cerebral blood circulation and antihypoxic activity. The 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) are prepared by treating an oxo derivative of the general formula (II) <CHEM> wherein R, X and Y are as given above in an organic solvent by a reducing agent and reacting the obtained 1,2,3,6-tetrahydropyridine derivative of the general formula (I), wherein R, X and Y are as given above, with a mineral or organic acid and converting the same, if desired, to an acid addition salt.
Patent IL-104765-A0 (IL)
Title: Production of cyclic esters from hydroxy carboxylic acids and derivatives thereof
IPC: C08L67/04
Filed: 1993-02-17
Abstract: Disclosed is a method for producing cyclic esters by the conversion of hydroxy carboxylic acids and their derivatives to their respective cyclic esters. Such cyclic esters, including lactide or glycolide, are particularly useful for producing polymers which can be used to make biodegradable materials, such as biodegradable packaging material. Various methods of cyclic ester production are disclosed, including liquid phase and vapor phase reactions. Also disclosed are various methods for recovering cyclic esters from product-containing streams.
Patent IL-106584-A0 (IL)
Title: A process for brominating methyl 2-(2-methylphenyl)-3-methoxypropenoate
IPC: C07C67/307
Filed: 1993-08-04
Abstract: PCT No. PCT/GB93/01592 Sec. 371 Date Feb. 9, 1995 Sec. 102(e) Date Feb. 9, 1995 PCT Filed Jul. 28, 1993 PCT Pub. No. WO94/05620 PCT Pub. Date Mar. 17, 1994.Process for preparing the (E)-isomer of a compound (II) by contacting the (E) or (Z) isomer of the 2-methylphenyl precursor, or a mixture of both, with bromine in an organic solvent, in the presence of a polymeric base and light.    <IMAGE>  (II)
Patent IL-108272-A0 (IL)
Title: A process for production of zealites
IPC: C01B39/40
Filed: 1994-01-05
Abstract: Zeolites having a SiO2 to Al2O3 ratio of more than 10, particularly ZSM-5 zeolites, are produced by:   (a) forming a reaction mixture (1) comprising a silica source, an aluminium source an inorganic base and templating agent and adjusting the pH to 10.7-11.7; (b) heating the reaction mixture whereby zeolite crystals (2) are formed; (c) separating the crystallized zeolite (2) from the reaction mixture leaving behind a residual mixture (3) and calcinating the zeolite to decompose the organic component; (d) adding to the residual mixture a templating agent at an amount so as to form a reaction mixture (4) wherein the level of the templating agent is as in the reaction mixture of step (a); and (e) repeating steps (a)-(d), with the reaction mixture (4) obtained in step (d) serving as the source for the templating agent of step (a) and every one or more cycles, treating the residual mixture of step (c) to remove salts therefrom.   <IMAGE>
Patent IL-126489-A0 (IL)
Title: Method for the prevention and treatment of mastitis
IPC: A23C9/123
Filed: 1997-06-19
Abstract: A method for treating or preventing mastitis in mammals is disclosed. The method contemplates the intramammary injection or dipping the teat with micrococcin antibiotics, preferably micrococcin P1 or P2, which do not interfere with the production of cheese and yoghurt using milk from treated animals. Hydrophobic antibiotics such as micrococcin P1 or P2 can be administered prior to infection to effectively suppress the rate, severity, and duration of subsequent bacterial infection, or can be administered subsequent to infection to effectively treat mastitis.
Patent IL-127497-A0 (IL)
Title: Method of treating psychiatric conditions
IPC: A61K31/517
Filed: 1998-12-10
Abstract: Use of a compound of formula 1 in the preparation of a medicament for treating a pshcyhiatic condition or disorder selected from dementia, dementia of the Alzheimer's type, anxiety disorders, psychotic episodes of anxiety, anxiety associated with psychosis, mood disorders associated with psychotic disorder, psychotic mood disorders, mood disorders associated with schizophrenia, dyskinesias and behavioral manifestations of mental retardation, conduct disorder and autistic disorder. <CHEM> or a pharmaceutically acceptable acid addition salt thereof, wherein     Ar is benzoisothiazolyl or an oxide or dioxide thereof each optionally substituted by one fluoro, chloro, trifluoromethyl, methoxy, cyano, nitro or napthyl optionally substituted by fluoro, chloro, trifluoromethyl, methoxy, cyano or nitro; quinolyl; 6-hydroxy-8-quinolyl; isoquinolyl; quinazolyl; benzothiazolyl; benzothiadiazolyl; benzoxazolyl; benzotriazolyl; benzoxazolyl; benzoxazolonyl; indolyl; indanyl optionally substituted by one or two fluoro, 3-indazolyl optionally substituted by 1-trifluoromethylphenyl; or phthalazinyl;   n is 1 or 2; and X and Y together with the phenyl to which they are attached form quinolyl; 2-hydroxyquinolyl; benzothiazolyl; 2-aminobenzothiazolyl; benzoisothiazolyl; indazolyl; 2-hydroxyindazolyl, indolyl; spiro; oxindolyl optionally substituted by one to three of (C1-C3)alkyl, or one of chloro, fluoro or phenyl, said phenyl optionally substituted by one chloro or fluoro; benzoxazolyl; 2-aminobenzoxazolyl; benzoxazolonyl; 2-aminobenzoxazolinyl; benzothiazolonyl; benzoimidazolonyl; or benzotriazolyl.
Patent IL-136379-A0 (IL)
Title: Processing chamber
IPC: G01N27/447
Filed: 2000-05-25
Abstract: A device having a processing chamber, for electroelution and/or dialysis of a substance carried in a sample with respect to an external liquid medium. The chamber has a closed end and an opening at the other end, sufficiently large to permit a sample, particularly a gel contained sample, to be inserted thereto. The chamber has two portals, each laterally disposed with respect to the opening. A tubular membrane covers the portals, and is sealingly fixed onto an outside surface of the housing. The device provides high yield recovery, saves time and allows for easy handling, especially regarding loading an unloading of small volume samples for dialysis, or inserting the gel slice containing the macromolecule sample. The device may be partially immersed in the liquid medium, with the opening above the liquid surface. Optionally, the device may be hermetically sealed via a cap, and fully immersed in the liquid medium.
Patent IL-138079-A0 (IL)
Title: 5-aminoindeno (1,2-c) pyrazol-4-ones as anti-cancer and anti-proliferative agents
IPC: A61K31/422
Filed: 1999-04-20
Abstract: The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
Patent IL-138423-A0 (IL)
Title: A process for the preparation of 2-benzo (b) thiophenecarboxylic acid derivatives
IPC: C07D333/70
Filed: 1999-03-01
Abstract: A process for the preparation of a substituted 2-benzo[b]thiophenecarboxylic acid compound or an alkali metal salt thereof, which comprises reacting a halobenzoyl derivative with mercaptoacetic acid in the presence of an alkali metal hydroxide and water. Substituted 2-benzo[b]thiophenecarboxylic acid compounds and alkali metal salts thereof are useful as intermediates for pharmaceuticals, agricultural chemicals, material preservatives, and the like.
Patent IL-138799-A0 (IL)
Title: Benzamide and sulfonamide substituted aminoguanidine and alkoxyguanidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
IPC: C07D211/62
Filed: 1999-04-05
Abstract: The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I:wherein X is O or NH, L is -O- or -SO2-, and R1-R4, R9-R19, Ra, Rb, Rc, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing the compounds of Formula I. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage.
Patent IL-147423-A0 (IL)
Title: Method and system for extracting application protocol characteristics
IPC: G06F13/00
Filed: 2000-06-29
Abstract: A method and computer program for automatically and continually extracting application protocols (i.e., defining a set of allowable or authorized actions) for any application. The method involves receiving a message from a server before it is sent or in parallel with sending to a client. The message may be in response to a specific request for it from the client. The program then extracts the application protocol data from the server message. Working with a copy of the message, the program strips off the communications protocol(s) from the message and parses the remaining message to identify user-selectable options contained in the message such as commands, fields, etc. These items represent the set of allowable or authorized user actions for the particular “stage” of the current version of the application as set forth in the message. The set of allowable user actions is then stored by the extraction program in a protocol database accessible to a gateway or filter module.
Patent IL-147577-A0 (IL)
Title: METHOD AND APPARATUS FOR AVOIDING DATA LOSS DURING A PPP RENEGOTIATION ON A Um INTERFACE
IPC: H04W88/02
Filed: 2000-07-14
Abstract: A method and a wireless communication device capable of flow controlling data to be sent from a TE2 device over a Rm interface when PPP renegotiation occurs over a Um interface. Flow control is asserted by the MT2 device by means of manipulating electrical signaling of a physical interface between the MT2 device and the TE2 device. A second embodiment provides a method and a wireless communication device for buffering data on the MT2 device when the PPP renegotiation of the Um interface occurs. In a third embodiment, data is buffered when the PPP renegotiation of the Um interface occurs. When an amount of free buffer space is less that a predetermined threshold, flow control is asserted to the TE2 device.
Patent IL-148748-A0 (IL)
Title: Method and apparatus for the production of mechanical power from hydraulic energy
IPC: B65H75/44
Filed: 2002-03-18
Abstract: The subject of the invention is an engine that is actuated by a fluid under pressure, preferably water, and comprises one or more oscillating, connecting-rod assemblies ( 13 ), including a cylinder ( 14 ) and a piston ( 15 ), and at least one or more cranks ( 16 ) driven by the connecting-rod assemblies ( 13 ). For each connecting-rod assembly ( 13 ), a preferably stationary valve ( 20 ) controls the feed and the discharge of the pressure fluid to and from it, synchronically with the angular position of the corresponding crank ( 10 ), and acts as the pivot about which connecting-rod assembly ( 13 ) oscillates. The engine can be applied for producing mechanical work in any apparatus, for example in sprinklers, concrete mixers, apparatus for winding cables or garden hose reels, and so on, or for the production of electrical energy. The actuating fluid can be used, after its discharge from the engine, for purposes for which high pressure is not required.