baber/WOPTO huggingface dataset:
Patent CA-3074951-A1 (CA)
Inventor: JONES BRYAN
IPC: A61K9/00
Filed: 2018-09-11
Abstract: Disclosed herein are safer formulations of resiniferatoxin (RTX) for intrathecal, intraganglionic intraarticular and pericardial administration. More specifically, there is disclosed alcohol-free formulations of RTX comprising a solubilizing component, a monosaccharide or sugar alcohol, a saline buffer, and RTX, and having narrow ranges for pH range and specific gravity.
Patent CA-3075912-A1 (CA)
Title: Iontophoretic systems, kits and methods for transdermal delivery of cosmetic agents
Inventor: IMRAN MIR A
IPC: A61N1/04
Filed: 2018-09-18
Abstract: Embodiments provide systems for delivering cosmetic agents (CA) into the skin. The system includes a power source and at least two electrode assemblies (EA) which may be attached or otherwise incorporated into a facemask assembly that fits over the users face. Each EA is configured to be held in contact with a facial or other skin layer. Additionally, each EA includes an electrode that is coupled to the power source to receive an output current from the power source. At least one of the EAs in the pair includes a medium that carries a CA, the medium being provided on the at least one electrode assembly to enable the output current to deliver the cosmetic agent into the epidermal dermal or other layer of the skin. Embodiments are particularly useful for delivering CAs into a selected layer of the skin to produce a desired cosmetic effect.
Patent CA-3076919-A1 (CA)
Title: Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer
Inventor: DIZEREGA GERE
IPC: A61K9/10
Filed: 2018-10-03
Abstract: Disclosed are combination therapy methods useful for the therapeutic treatment of cancer by combining local administration of compositions containing antineoplastic particles, such as taxane particles, with systemic administration of compositions containing immunotherapeutic agents. Local administration methods include topical application, pulmonary administration, intratumoral injection, intraperitoneal injection, arid intracystic injection.
Patent CA-3078157-A1 (CA)
Title: Method for generating multispecific antibodies from monospecific antibodies
Inventor: BRINKMANN ULRICH
IPC: A61K39/395
Filed: 2018-10-19
Abstract: Herein is reported a method for the generation of multispecific antibodies by a half- antibody exchange reaction between two 2/3-IgGs destabilized in one half by asymmetric perturbing mutations fostering the generation of correctly assemble full length bispecific antibodies. The method can be performed in the absence of reducing agents and does not require hinge region disulfide bonds in the starting 2/3-IgGs.
Patent CA-3080102-A1 (CA)
Title: Purine based compounds as toll-like receptor 9 antagonist
Inventor: TALUKDAR ARINDAM
IPC: A61P37/02
Filed: 2018-11-05
Abstract: The present invention provides novel purine based compounds of formula 1, method of preparation of purine based compounds and its composition useful for inhibiting signalling through Toll-like receptors. These compounds are useful in inhibiting immune stimulation involving toll -like receptor 9 (TLR9).  These can be used in treatment of autoimmune disease and inflammation where aberrant activation of TLR9 plays role.
Patent CA-3081072-A1 (CA)
Title: Adjuvant and vaccine compositions
Inventor: GERBER JAY D
IPC: A61K47/46
Filed: 2013-03-12
Abstract: Methods are provided for preparing and delivering an adjuvant for vaccines including lecithin, polymer and one or more additives. The polymer is preferably polyacrylic acid-based. The additive is preferably one or more of a glycoside and a sterol. The method of preparation includes hydrating lecithin and a polymer in saline or water and mixing the lecithin and polymer to form the adjuvant. Additives can be included prior to or after hydration of the lecithin and polymer.
Patent CA-3083977-A1 (CA)
Title: Vaccin pour la protection contre le streptococcus suis
Inventor: JACOBS ANTONIUS ARNOLDUS CHRISTIAAN
IPC: A61K39/09
Filed: 2018-12-14
Abstract: La présente invention concerne un vaccin comprenant une quantité immunologiquement efficace d'un antigène de protéase IgM de Streptococcus suis, destiné à être utilisé dans une méthode de protection des porcs contre une infection pathogène par Streptococcus suis par administration du vaccin uniquement une fois, le vaccin comprenant au plus 120 µg par dose de l'antigène.
Patent CA-3085962-A1 (CA)
Title: Ensemble de chauffage par induction destine a un dispositif de generation de vapeur
Inventor: VANKO DANIEL
IPC: A24F40/465
Filed: 2018-12-20
Abstract: La présente invention concerne un ensemble de chauffage par induction (22) destiné à un dispositif de génération de vapeur (10), comprenant une bobine d'induction (32) et un compartiment de chauffage (24) disposé de façon à recevoir une cartouche pouvant être chauffée par induction (26). Une première couche de blindage électromagnétique (36) est disposée à l'extérieur de la bobine d'induction (32) et une seconde couche de blindage électromagnétique (46) est disposée à l'extérieur de la première couche de blindage électromagnétique (36). Les première et seconde couches de blindage électromagnétique (36, 46) diffèrent en termes de conductivité électrique et/ou de perméabilité magnétique.
Patent CA-3087103-A1 (CA)
Title: Systeme et procede de traitement de liquide hemorragique pour de l'autotransfusion
Inventor: GADRAT FRANCIS
IPC: A61M1/02
Filed: 2018-12-21
Abstract: Un système de traitement d'un liquide hémorragique préalablement prélevé d'un patient pour une autotransfusion, incluant une unité de traitement du liquide hémorragique comprenant : un dispositif de filtration pour filtration tangentielle comprenant une membrane de filtration ; une poche de traitement permettant une circulation du liquide hémorragique dans la ligne de recirculation dans un sens allant de la sortie vers l'entrée de la poche de traitement à travers la chambre d'admission du dispositif de filtration; une ligne de nettoyage pour amener un liquide de nettoyage dans ladite chambre d'évacuation; et un premier organe de régulation de flux agencé  pour une régulation de flux dans la ligne de nettoyage et un deuxième organe de régulation de flux agencé pour une régulation de flux dans une ligne d'évacuation reliée fluidiquement à la sortie de la chambre d'évacuation afin de pouvoir contrôler la pression de liquide de nettoyage dans la chambre d'évacuation.
Patent CA-3089037-A1 (CA)
Inventor: CARVALHO VITOR R
IPC: G06F16/2452
Filed: 2019-07-26
Abstract: Selon la présente invention, détecter des questions dupliquées à l'aide d'une adaptation de domaine contradictoire de gradient inverse consiste : à appliquer un réseau général à de multiples paires de questions générales pour obtenir un premier ensemble de pertes, un réseau de domaine cible est appliqué à de multiples paires de réseaux spécifiques de domaine pour obtenir un deuxième ensemble de pertes. En outre, un réseau de distinction de domaine est appliqué à un ensemble de questions spécifiques à un domaine et à un ensemble de questions générales pour obtenir un troisième ensemble de pertes. Un ensemble de gradients accumulés est calculé à partir du premier ensemble de pertes, du deuxième ensemble de pertes, et du troisième ensemble de pertes. De multiples caractéristiques sont mises à jour conformément à l'ensemble de gradients accumulés pour entraîner le réseau de domaine cible.
Patent CA-3090761-A1 (CA)
Inventor: MATSON WAYNE
IPC: A61K9/48
Filed: 2013-03-26
Abstract: lndole-3-propionic acid as a marker and for treatment for Huntington Disease.  An exemplary pharmaceutical composition for treating or preventing neurodegenerative 3 disease, hypertension, stroke, ischemic heart disease or head injury in an animal, or for delaying or ameliorating the effects of said disease or injury in an animal suffering from same may comprise indole-3-propionic acid or a salt or ester or protein 6 complex or inorganically bound preparation thereof and a pharmaceutically acceptable carrier therefor.
Patent CA-3093752-A1 (CA)
Title: Targeted treatment with a topical cream of cannabinoids, terpenes, and essential oils
Inventor: WEBB YVETTE ROSE
IPC: A61K31/05
Filed: 2020-09-21
Abstract: Prior art describes methods for making whole-plant extracts from the cannabis plant.  Terpenes and cannabinoids are classes of compounds found inherently in those extracts. But, because those extracts contain hundreds of different, and sometimes counteracting, compounds, they are not the most effective treatments for common health issues. Specific terpenes and cannabinoids may be isolated and chosen for their use for specific conditions.  Examples of the present invention differ from the prior art by selecting isolated compounds (Like the cannabinoid THC and the terpene Myrcene) and specifically combining them essential oils (which are known to increase mood and relieve pain) and topical agents to produce targeted treatments.
Patent CA-3095710-A1 (CA)
Title: Hydrocarbon / lipid - carotenoid complexes
Inventor: PETYAEV IVAN
IPC: A23L33/115
Filed: 2019-02-07
Abstract: The invention relates to uses of hydrocarbon / lipid complexes with carotenoids for improvement properties of hydrocarbon-based products as well as related methods and uses.
Patent CA-3095720-A1 (CA)
Inventor: NAVRATIL ZORAN
IPC: G07C5/00
Filed: 2019-03-29
Abstract: Aspects of the disclosure relate to enhanced telematics processing systems with improved third party source data integration features and enhanced customized driving output determinations. A computing platform may receive telematics data and third party source data. The computing platform may enrich the telematics data using the third party source data. After generating the enriched telematics data, the computing platform may use machine learning algorithms and datasets to validate the enriched telematics data. The computing platform may ingest, via a batch ingestion process, the enriched telematics data. For example, the computing platform may store the enriched telematics data and generate additional enriched telematics data until expiration of a predetermined period of time. The computing platform may ingest the enriched telematics data associated with each trip. Once the enriched telematics data has been ingested, the computing platform may generate a standardized common trip format output for each trip.
Patent CA-3102779-A1 (CA)
Inventor: NELLES DAVID A
IPC: C12N15/113
Filed: 2019-06-07
Abstract: Disclosed are compositions comprising: (a) a sequence comprising a guide RNA (gRNA) that specifically binds a target sequence within an RNA molecule and (b) a sequence encoding a fusion protein, the sequence comprising a sequence encoding a first RNA-binding polypeptide and a sequence encoding a second RNA-binding polypeptide, wherein neither the first RNA-binding polypeptide nor the second RNA-binding polypeptide comprises a significant DNA-nuclease activity, wherein the first RNA-binding polypeptide and the second RNA-binding polypeptide are not identical, and wherein the second RNA-binding polypeptide comprises an RNA-nuclease activity. Methods of making and methods of using compositions of the disclosure are also provided. For example, compositions of the disclosure may be used in the treatment of a disease or disorder in a subject. Exemplary disease or disorders of the disclosure include genetic and epigenetic diseases or disorders.
Patent CA-3104624-A1 (CA)
Title: Dialysate bag heater tray for peritoneal dialysis systems
Inventor: ORTEGA ANTHONY THOMAS
IPC: A61M1/16
Filed: 2019-06-05
Abstract: In one aspect, a peritoneal dialysis system (100) includes a tray (116) for supporting a bag (124) that can receive dialysate from a source (122) of dialysate, multiple force sensors (218) disposed adjacent a portion (202) of the tray (116) that is in contact with the bag (124) when the bag (124) is supported by the tray (116), and one or more processors configured to receive data from the multiple force sensors (218) and to determine, based on the data, an amount of dialysate contained in the bag (124).
Patent CA-3105426-A1 (CA)
Inventor: MUTCHNIK MICHAEL
IPC: A41D13/11
Filed: 2021-01-08
Abstract: A face protector designed to reduce the risk of airdrop penetration into the respiratory system, set forth by way of example and not limitation. The face protector comprises a face mask and a light indicator, adjusted to and designated for the face mask protective potential identifying. The light indicator is being fashioned with at least one of green, yellow and red flashing to indicate mask readiness for use, mask useable but still possible to be used some period of time, and mask cannot be used accordingly. The light indicator's potential operational durability is suitable to a protective potential durability of the face mask.
Patent CA-3105671-A1 (CA)
Inventor: KULAZYNSKI MAREK
IPC: C07K7/06
Filed: 2019-05-30
Abstract: L'invention concerne un procédé d'élimination de lipopeptides présents dans des solutions et de modification de leur structure de cyclique à linéaire, caractérisé en ce que la capture et la séquestration des lipopeptides ont lieu à partir de solutions contenant de l'eau par sorption, et dans le cas de lipopeptides cycliques, dans lesquels l'anneau peptidique est fermé par une liaison lactone, la sorption est en outre associée à des réactions d'hydrolyse se produisant sur la surface du carbone actif, conduisant à la linéarisation suite à la rupture de la liaison lactone.
Patent CA-3108863-A1 (CA)
Title: Therapeutic agent for humoral immunity-related diseases in materno-fetal relationship
Inventor: YAMAGUCHI KOUSHI
IPC: A61K31/407
Filed: 2019-08-09
Abstract: Provided is a medicine for treating or alleviating humoral immunity-related diseases in the materno-fetal relationship, for example, sterility and infertility, blood type incompatible pregnancy, or fetal hemochromatosis which is caused by humoral immunity in the materno-fetal relationship, the medicine comprising, as an active ingredient, a compound selected from the group consisting of: (i) a compound represented by formula (I) (where each symbol is the same as that in the specification) or a pharmaceutically acceptable salt thereof; (ii) cyclosporine; and (iii) a rapamycin derivative.
Patent CA-3108979-A1 (CA)
Inventor: COLLOCA STEFANO
IPC: C12N7/01
Filed: 2010-02-02
Abstract: Abstract The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease. Date Recue/Date Received 2021-02-16
Patent CA-3109557-A1 (CA)
Inventor: LAWTON GRAHAM
IPC: A61P1/12
Filed: 2019-08-19
Abstract: The present invention relates to novel crystalline Forms D, E and F of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[l-(4- phenyl-lH-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid, methods of preparing the same and their pharmaceutical compositions for use in treating opioid receptor mediated diseases.
Patent CA-3110659-A1 (CA)
Inventor: BEAUDOIN NORMAND
IPC: F02C3/045
Filed: 2021-03-01
Abstract: Cette invention est dédiée à mon frère Robert, qui a dédié sa vie à l'ingénierie et qui nous a quitté trop tôt , à l'âge de 62 ans , des suites d'un cancer lymphatique eu'il a combattu pendant huit longues ans , avec sa femme Linda. Cette invention est donc aussi dédié à leur courage, et à leur amour commun de la vie ... ... et à Chantal, pour son dévouement à me laisser travailler
Patent CA-3111189-A1 (CA)
Inventor: MALAPELLE PAOLO
IPC: H02M7/00
Filed: 2018-08-29
Abstract: A drive system (300) includes a plurality of power cells (312) supplying power to one or more output phases (A, B, C), each power cell (312) having multiple switching devices (315a-d) incorporating semiconductor switches, 5 and a control system (400) in communication with the plurality of power cells (312) and controlling operation of the plurality of power cells (312), wherein the control system (400) includes a system on chip (410) with one or more central processing units (412, 414) and a field programmable gate array (416) in communication with the one or more central processing units (412, 414).
Patent CA-3112608-A1 (CA)
Title: High efficiency compact slotted antenna with a ground plane
Inventor: FLEMMING JEB H
IPC: H01P3/12
Filed: 2019-09-11
Abstract: The present invention includes a method of making a slotted waveguide antenna structure with a matched ground plane comprising: forming in a photosensitive glass substrate a coaxial-to-coplanar waveguide (CPW) section connected to a power divider, an emission cavity area for the slotted antenna and one or more vias; depositing a metal ground plane to a first surface of the photosensitive glass substrate; depositing a copper layer on the photosensitive glass substrate with a pattern of slots that form a slot antenna above the emission cavity; forming one or more glass pillars in the emission cavity under the slot antenna; etching away the photosensitive glass in the emission cavity while retaining the one or more glass pillars; connecting a micro coaxial connector to the coaxial-to-coplanar waveguide (CPW) section; and one or more solder bumps at the vias that connect to the ground plane, to form a slotted antenna.
Patent CA-3112620-A1 (CA)
Title: Systems and methods for managing information about building resources
Inventor: DHANDAPANI CHANDRA
IPC: G06F16/23
Filed: 2019-09-24
Abstract: In accordance with some embodiments, a method managing information about building resources is disclosed. In accordance with some embodiments, a method for providing data to an end user application is disclosed. A method may include identifying a data model representing information about building resources for tenants and investors in various locations, updating information in the data model, and providing the updated information to a client device for use in an application that provides information about building resources.
Patent CA-3112963-A1 (CA)
Title: Baseball base
Inventor: GARLAND TYLOR
IPC: A63B69/00
Filed: 2019-09-26
Abstract: A base for use in athletic base running games includes a ground anchor assembly that includes: a post for insertion into a ground playing surface, and a base portion disposed along a top of the post. The base also includes a reinforcement plate, such as an X-plate, coupled to a top surface of the base portion. The X-plate has four arms arranged in an X orientation for providing increased stiffness in the four comers of the base. The arms extend radially outward from the base portion. A cover is disposed over and is coupled to the X-plate and can be formed as part of an overmold process.
Patent CA-3114404-A1 (CA)
Title: Composition pour la diffusion de substances volatiles
Inventor: LLORENTE ALONSO JOAQUIM
IPC: A01M1/20
Filed: 2019-09-26
Abstract: L'invention concerne une composition pour la diffusion de substances volatiles, comprenant de la cire, qui comprend en outre un matériau solide qui comprend des substances volatiles, ledit matériau solide se présentant sous la forme de particules, et qui présente une capacité d'absorption de substances volatiles supérieure à la capacité d'absorption de substances volatiles de la cire. L'invention permet d'obtenir une composition pour la diffusion de substances volatiles qui permet d'augmenter le pourcentage de substances volatiles, c'est-à-dire le pourcentage de parfum, et d'allonger le temps de libération.
Patent CA-3115169-A1 (CA)
Inventor: LUSCHER ANDRE
IPC: G07C9/00
Filed: 2019-10-17
Abstract: An access control terminal (1), comprising an electronic circuit (11) and an ultra-wide-band transceiver (10) connected to the electronic circuit (11) wherein the electronic circuit (11) exchanges messages with a mobile device (2) to determine a distance (d) of the mobile device (2) from the access control terminal (1), and to transmit to the mobile device (2) one or more update messages configured to update access rights data in the mobile device (2), if the mobile device (2) is within the pre-determined proximity range (P).
Patent CA-3117924-A1 (CA)
Inventor: FINER MITCHELL H
IPC: C12N15/86
Filed: 2019-11-13
Abstract: The present disclosure relates to polynucleotides comprising a nucleic acid sequence encoding a replication competent viral genome, wherein the polynucleotide is capable of producing a replication competent virus when introduced into a cell by a non-viral delivery vehicle. The present disclosure further relates to the encapsulation of the polynucleotides and the use of the polynucleotides and/or particles for the treatment and prevention of cancer.
Patent CA-3118616-A1 (CA)
Title: Selection de lymphocytes t reactifs a une tumeur ameliores
Inventor: SIMPSON-ABELSON MICHELLE
IPC: A61K35/17
Filed: 2019-11-04
Abstract: La présente invention concerne des procédés de présélection de TIL (lymphocytes infiltrant les tumeurs) sur la base de l'expression de PD-1, ainsi que des procédés d'expansion de ces TIL positifs à PD-1 présélectionnés afin de produire des populations thérapeutiques de TIL présentant une capacité de destruction spécifique à une tumeur améliorée (par exemple, une cytotoxicité améliorée)<i />.
Patent CA-3119038-A1 (CA)
Title: Semi-autonomous system for carrying and placing elongate objects
Inventor: CHABALA JOSEPH E
IPC: E04G21/00
Filed: 2019-12-19
Abstract: An improvement to a semi-autonomous apparatus (10) is described herein. In an apparatus having a gantry subassembly (100), a tram subassembly (200) movably mounted on the gantry subassembly (100), and an actuation subassembly (300) mounted on the tram subassembly (200), the improvement includes a gripper subassembly (400) operatively connected to the actuation subassembly (300). The movement of the subassemblies is controlled in part by a control system that controls drive systems associated with one or more of the subassemblies. The gantry subassembly (100) includes a bridge member (102) for laterally spanning a selected section of a work site. The tram subassembly (200) includes a tram (202) that travels laterally along to the bridge member (102). The actuation subassembly (300) includes at least one motion actuator for controlling the movement of the gripper subassembly (400) in a generally vertical direction and may include an additional motion actuator for movement in a generally horizontal direction. The gripper subassembly (400) includes passively actuated grippers (402) for lifting, transporting and placing objects (52, 54), and particularly, elongate objects such as reinforcing bars used in road and other cementitious surface construction.
Patent CA-3119238-A1 (CA)
Inventor: VONARBURG CEDRIC PIERRE
IPC: A61P31/00
Filed: 2019-12-02
Abstract: This invention is in the field of preventing or treating acute exacerbations in chronic lung diseases, such as chronic obstructive pulmonary disease and non-cystic fibrosis bronchiectasis, by administration of polyclonal immunoglobulin to the respiratory tract, in particular by direct application of an aerosolized composition comprising polyclonal immunoglobulin.