Patent SG-11201804037X-A (SG)
Title: Injection solution comprising a non-nucleoside reverse-transcriptase inhibitor and poly(lactide-co-glycolide)
Inventor: WINDHAB NORBERT
IPC: A61K47/34
Filed: 2016-11-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau res., 00) ..... ..s,„,„.1 (43) International Publication Date r 26 May 2017(26.05.2017) WIPO I PCT ID Hit (10) WO International 2017/084973 1111111111111111111111111111111111111111111111111111111111111t111111111111111 Publication Number Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 9/00 (2006.01) A61K 47/34 (2017.01) kind of national protection available): AE, AG, AL, AM, A61K 47/22 (2006.01) A61K 31/505 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP2016/077402 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 11 November 2016 (11.11.2016) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/255,866 16 November 2015 (16.11.2015) US (84) Designated States (unless otherwise indicated, for every 15197777.4 3 December 2015 (03.12.2015) EP kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: EVONIK ROHM GMBH [DE/DE]; TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Kirschenallee, 64293 Darmstadt (DE). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: WINDHAB, Norbert; UbierstraBe 20, 65719 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Hofheim (DE). JABER, Rima; Rudolfstr. 4, 60327 Frank- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, fort (DE). SCHRODER, Axel; Geschwister-Scholl-Str. 4, 64354 Reinheim (DE). BURTON, Kevin; 616 Founders GW, KM, ML, MR, NE, SN, TD, TG). Park Drive West, Hoover, Alabama 35226 (US). TICE, Published: Tom; 5317 Mountain Park Indian Circle, Springs, 21(3)) with international search report (Art Alabama 35124 (US). (74) Agent: GOTTSCHALK, Michael; Evonik Industries AG, CI-IPM-PAT, Postcode 84/339, Rodenbacher Chaussee 4, 63457 Hanau (DE). (54) Title: INJECTION SOLUTION COMPRISING A NON-NUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITOR AND POLY(LACTIDE-CO-GLYCOLIDE) Fig 1 2 1,8 1,6 1,4 E 1,2 11 13 r i i 1 .4t 0 u , -3 , 0 8 en 0,6 IN • R 752 - 5 0,4 Cr\ /a it 0,2 Ge 0 I - • R 752-15 O 0 1000 2000 3000 4000 5000 IN time [min] 11 C (57) : The invention is concerned with an injection solution, comprising an organic solvent, a copolymer, which is a ei poly(lactide-co-glycolide) dissolved in the organic solvent and a pharmaceutical active ingredient which is non-nucleoside inhibitor 0 of the HIV reverse transcriptase or of the HIV integrase, which contains aromatic and heterocyclic aromatic or aromatic and hetero - cyclic aromatic and aliphatic heterocyclic groups, wherein the content of the pharmaceutical active ingredient is from about 8 to about 25% by weight of the copolymer solution.