Patent SG-11201407372U-A (SG)
Title: Nampt inhibitors
Inventor: CLARK RICHARD F
IPC: A61K31/407
Filed: 2013-05-10
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/170112 A1 (51) International Patent Classification: C07D 471/04 (2006.01) A61P 29/00 (2006.01) A61K31/407 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/645,679 61/718,998 61/779,626 PCT/US2013/040476 10 May 2013 (10.05.2013) English English US US us 11 May 2012 (11.05.2012) 26 October 2012 (26.10.2012) 13 March 2013 (13.03.2013) (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan Road, North Chicago, Illinois 60064 (US). (72) Inventors: CLARK, Richard F.; 2142 Spruce Pointe Ct., Gurnee, Illinois 60031 (US). SORENSEN, Bryan; 524 First St., Antioch, Illinois 60002 (US). OSUMA, Au­ gustine T.; 729 Crosswind Lane, Lindenhurst, Illinois 60046 (US). FREY, Robin; 1037 Shari Lane, Libertyville, Illinois 60048 (US). LONGENECKER, Kenton; 1371 Osage Orange Road, Grayslake, Illinois 60030 (US). DO- HERTY, George; 1605 Bush Ct., Libertyville, Illinois 60048 (US). CURTIN, Michael L.; 8625 113TH Ave., Pleasant Prairie, Wisconsin 53158 (US). MI- CHAELIDES, Michael R.; 4452 W. Gavin Ln, Liber­ tyville, Illinois 60048 (US). SWEIS, Ramzi F.; 1012 Plaister Ave., Lake Bluff, Illinois 60044 (US). PLI- USHCHEV, Marina A.; 337 Albert Dr., Vernon Hills, Illinois 60061 (US). JUDD, Andy; 138 Mainsail Dr, Grayslake, Illinois 60030 (US). HANSEN, Todd M.; 191 Seymour Ave., Grayslake, Illinois 60030 (US). HEYMAN, Howard R.; 827 Woodward Ave., Deerfield, Illinois 60015 (US). (74) Agents: GESICKI, Glen J et al.; 100 Abbott Park Road, Bid AP06A-1/V377, Abbott Park, Illinois 60064 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) < CJ o i> i-H o CJ (54) Title: NAMPT INHIBITORS (57) Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and meth­ ods of treating diseases during which NAMPT expressed. is