baber/WOPTO huggingface dataset:
Patent PT-1049794-E (PT)
Inventor: KLEBER HANS-PETER
IPC: C12P13/00
Filed: 1998-11-09
Abstract: L(-)-carnitine is synthesized from crotonobetaine, crotonobetaine salts or derivatives in an ecologically advantageous manner by immobilizing cells of Escherichia coli 044 K74 on ceramics, glass beads or polyurethane disks in a two stage continuously operating cell recycle reactor containing a reaction medium. The medium preferably contains between 25 mM and 1 M crotonobetaine and at least 50 mM fumarate. Growing or resting cells of E. coli are retained in the reactor by micro or ultrafiltration membranes which are arranged as a flat membrane module or hollow fiber module. A first stage contains a reactor tank and a second stage contains an external recirculation loop connected to the tank for feeding the reaction medium through a filter unit. L-carnitine is synthesized under anaerobic conditions to produce a reaction medium containing L-carnitine and unreacted crotonobetaine. The reaction medium is transferred through the recirculation loop to the filter unit to produce a filtrate containing L-carnitine and a residue containing unreacted crotonobetaine and cells. The residue is recirculated to the reactor tank.
Patent PT-1010960-E (PT)
Inventor: DINGS FRANCISCUS CORNELIS
IPC: F27D3/12
Filed: 1999-12-17
Abstract: A furnace for heating articles is provided with a housing containing heating means (16) as well as a feed and a discharge between which a track (13,23,25) extends for moving the articles through the furnace. The heating means (16) comprise at least one source which emits radiation having a wavelength located in the range of light radiation, such as an infrared source, and the track for moving the articles comprises a material transparent to light radiation. <IMAGE>
Patent PT-1053256-E (PT)
Title: Antibodies to death receptor 4 (dr4) and uses thereof
Inventor: KIM KYUNG JIN
IPC: A61P35/00
Filed: 1999-01-25
Abstract: Death Receptor 4 (DR4) antibodies are provided. The DR4 antibodies may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treatment and diagnosis using the DR4 antibodies are also provided.
Patent IE-36119-L (IE)
Title: Moulded fibre pulp container
IPC: B65D85/32
Filed: 1972-02-24
Abstract: 1347946 Pulp-moulding LEEUWARDER PAPIERWARENFABRIEK NV 24 Feb 1972 [24 Feb 1971] 8602/72 Heading B5A [Also in Division B8] In a suction mould 15 for producing a pulp container having integrally hinged lid and bottom sections (5 and 1, Fig. 1), upstanding ridges 19 are provided in a planar surface of the mould to produce reinforcing ribs or channels on the under surface of a substantially flat part of the lid section. To make the container liquid is drawn off a pulp mass by suction applied through metal gauzes 20, 21 to deposit a layer of pulp. The pulp layer on the ridges 19 is then sucked off by a vacuum applied through ducts 24, 25 of a transfer mould 23 or blown off and the whole container withdrawn from the suction mould 15 into the transfer mould 23 where it is dried. In the embodiment shown the ridges are wholly covered by a layer of pulp so that during the blowing or sucking off operation the pulp around each ridge is formed into a channel having a restricted mouth opening into said flat part of the lid section; alternatively the ridges are not covered with a layer of pulp along their top edges so that upon blowing or sucking off, the pulp deposited on each ridge forms divergent ribs extending from the edges of a slot formed in said flat part of the lid section.
[GB1347946A]
Patent IE-42475-L (IE)
Title: Biphenylyl ethers
IPC: C07D295/08
Filed: 1976-02-06
Abstract: Biphenylyl ethers of the formula <IMAGE> and their physiologically acceptable acid addition salts exhibit pharmaceutically useful serum cholesterol and triglyceride lowering, fibrinolytic, thrombocyte aggregation inhibition, beta -receptor blocking and neuroleptic effects.
[US4070461A]
Patent IE-870633-L (IE)
Title: Pyrimidine carboxylic acid derivatives
IPC: A61P9/08
Filed: 1987-03-11
Abstract: Cardiovascular activity is exhibited by compounds having the formula <CHEM> and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur; R is hydrogen, alkyl, cycloalkyl, aryl, or arylalkyl and R1 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, <CHEM> or halo substituted alkyl, or R and R1 taken together with the nitrogen atom to which they are attached are 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, 4-thiamorpholinyl, 1-piperazinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl, 4-diarylalkyl-1-piperazinyl or 1-pyrrolidinyl, 1-piperidinyl, or 1-azeipinyl substituted with alkyl, alkoxy, alkylthio, halo, trifluoromethyl or hydroxy; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, <CHEM> or halo substituted alkyl; R3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, <CHEM> or halo substituted alkyl; R4 is aryl or heterocyclo; R5 and R6 are each independently hydrogen, alkyl, -(CH2)q-aryl or -(CH2)q-cycloalkyl; Y1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, amino, substituted amino, carbamoyl, (substituted amino)- @-, heterocyclo-(CH2)m- @-, carboxyl, alkoxycarbonyl, alkyl- @-, aryl-(CH2)m- @-, alkyl-@-O- or aryl-(CH2)m- @-O- Y2 is cycloalkyl, aryl, heterocyclo, carbamoyl, (substituted amino)- @-, carboxyl, alkoxycarbonyl, alkyl- @-, aryl-(CH2)m- @- or heterocyclo-(CH2)m- @-; Y3 is hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, alkyl- @-O-, aryl-(CH2)m- @-O-, amino, or substituted amino; q is 0, 1, 2 or 3; m is 0 or an integer of 1 to 6; n is 0 or an integer of 1 to 5; and p is an integer of 1 to 5. 5
[EP0237347A2]
Patent IE-34200-L (IE)
Title: Hydrophilising electrophotographic offset plates.
IPC: B41N3/08
Filed: 1970-05-19
Abstract: 1,259,555. Lithography. GESTETNER Ltd. May 20, 1970 [May 21, 1969], No. 26035/69. Heading G2M. Electro-photographic ZnO materials bearing a fixed image are converted to lithographic printing plates by (1) wetting with an aqueous solution of Al formate or acetate, and (2) drying. The solution preferably also contains ethanol and a polyhydric alcohol (e.g. ethylene glycol or glycerin).
[GB1259555A]
Patent IE-36411-L (IE)
Title: Tobacco aroma substances.
IPC: A24B15/26
Filed: 1972-06-09
Abstract: 1383029 Tobacco extract H F and P H F REEMTSMA 2 June 1972 [9 June 1971] 25837/72 Heading A2C Tobacco aroma substances are obtained by extracting tobacco to isolate only those components of the tobacco which are soluble in a solvent or solvent mixture lying in the mixotropic series of K Macek in Handbuch der Papierchromatographie, vol. I, VEB Gustav Fischer-Verlag, Jena (1958) between trichloroethylene and ethyl acetate inclusive and then, in order to activate precursers of smoke flavour materials, subjecting the residue obtained after removing the solvent(s) from the isolate solution to heat treatment at a temperature between 30C and 260C inclusive. The residue may be fractionated by differential solvent extraction processes with solvents lying outside the above limits to further isolate the natural aroma substances of tobacco from undesired associated substances.
[GB1383029A]
Patent IE-820810-L (IE)
Title: Pharmaceutical preparations for treatment of diabetes
IPC: A61K9/22
Filed: 1982-04-06
Abstract: Pharmaceutical preparations e.g. tablets, dragees or capsules of prolonged effect for the treatment of pathological manifestations connected with diabetes, which contain benfluorex hydrochloride as active ingredient, e.g. the benfluorex hydrochloride may be included in a digestible hydrophobic matrix and then dispersed in compressible excipients forming a hydrophilic network and a pharmaceutical combination which comprises a rapid release component of benfluorex hydrochloride and slow release component of benfluorex hydrochloride, these are usually present together in the same formulation and the slow release component may be composed in the same way as a single-component preparation.
[GB2099299A]
Patent IE-780857-L (IE)
Title: Dental impression tray
IPC: H02K5/06
Filed: 1978-04-28
Abstract: An apparatus and a method is described for smoothing the acceleration and deceleration of an electric motor. This is accomplished by using a pair of brush springs (strong and weak) for each brush of an electric motor. At low speeds, the strong spring is retracted so that the force with which the brush is applied to the motor commutator is greatly reduced. This reduced frictional force improves the smoothness of the acceleration and deceleration characteristics of the motor at low speeds.
[US4142138A]
Patent IE-44830-L (IE)
Title: Benzodiazepine derivatives.
IPC: C07D243/16
Filed: 1977-05-03
Abstract: The invention relates to benzodiazepine compounds of the formula: <IMAGE> wherein R5 is C1-C4 alkyl, R3 is C1-C4 alkyl, and R4 is selected from Cl and F, and medicaments containing such benzodizepine compounds.
[US4235897A]
Patent IE-33234-L (IE)
Title: Thiazacyclic hydroxy compounds
IPC: C07D499/00
Filed: 1969-07-16
Abstract: 1281548 4-Thia-1-azabicyclo[3,2,0]heptan-7- ones CIBA-GEIGY AG 16 July 1969 [23 July 1968 11 Dec 1968] 35885/69 Heading C2C Novel 4-thia-1-azabicyclo[3,2,0]heptan-7-ones of the Formula I wherein Ac in the acyl radical of an organic acid and 0-esters of such compounds are prepared by treating with chemical reducing agents under neutral or weakly acidic conditions in the presence of water compounds of the Formula II in which R 0 is a 2-halo-C 1-7 alkyl radical and, if desired, in acylating the free hydroxyl group in the 2-position of the resulting compounds and/or, if desired, in resulting compounds having protected functional groups in the acylamino groups, liberating said groups and/or, if desired, resolving resulting isomer mixtures.
[GB1281548A]
Patent FI-851773-L (FI)
Inventor: KOUSEK HEINZ
IPC: F16B13/14
Filed: 1985-05-06
Abstract: In securing an anchor in a borehole in a receiving material, a settable hydraulic dowel compound is introduced into the borehole either before, during or after the placement of the anchor member. The dowel compound includes an expandable component. The diameters of the borehole and the anchor member are selected so that an annular gap extends around the anchor member with the gap having a maximum area of 200 mm2. The expandable component ensures an increase in the volume of the dowel component above the initial volume in a free expansion procedure.
Patent IE-841135-L (IE)
Title: Marine structure
IPC: B63B35/44
Filed: 1984-05-08
Abstract: A flexible structure of controlled yieldability for use as a hydrocarbon drilling and production platform in deep seas, or as a mooring point for oil tankers, constituted by a foundation base assembly, a vertical cylindrical tubular element placed under tension by a buoyancy chamber disposed at its top in proximity to the water surface, and an overlying lattice which at its top supports the plant platform. The tubular element is connected at its lower end to the base and at its upper end to the buoyancy chamber by means of suitable profiled tapered terminal elements able to withstand the bending loads which are generated at said connections. The entire structure is constituted by four separate pieces, namely the foundation base assembly with the lower terminal element, the lower half of the cylindrical tubular element, the upper half thereof, and the upper buoyancy chamber which is connected at one end to the upper terminal connection element and at the other end to the top lattice. For transportation purposes, these four pieces are assembled telescopically in pairs. On final on-site installation, the telescopic tubular parts are connected together and to the respective profiled terminal elements by mechanical clamps which restore complete structural continuity along the entire axis of the structure.
[US4695193A]
Patent IE-881277-L (IE)
Title: Process and intermediates for preparing 4-substituted¹prolines
IPC: C07D207/22
Filed: 1988-04-29
Abstract: A compound (for preparing an ACE inhibitor), namely, triphenyl cerium and a process for preparing same by reacting cerium trichloride (CeCl3) with phenyllithium, are provided.
[US4851514A]
Patent IE-34576-L (IE)
Title: Die-casting metals
IPC: B22D17/20
Filed: 1970-10-14
Abstract: Die-casting apparatus, primarily for casting ferrous metals, including a shot duct formed from two or more longitudinally successive structurally separate components which may be made of respective different materials or of the same material, in either case selected to suit the operating conditions to which they are exposed. The components are supported partly by one of the dies and partly by a casing such that the degree of tightness of interference between the casing and the components supported therein is selected to provide a controlled degree of radially outward conduction of heat thereby to control the operating environment of the components.
[US3685572A]
Patent IE-34717-L (IE)
Title: Textile treatment for shrink resistance
IPC: D06M101/00
Filed: 1970-11-11
Abstract: 1327395 Textile shrink-resistance IWS NOMINEE CO Ltd and CIBA-GEIGY AG 11 Nov 1970 [18 Nov 1969] 56474/69 Heading D1P A process for milling a textile fabric consisting wholly or partially of keratinous fibres and simultaneously treating it with a resin imparting shrink-resistance, comprises: (a) agitating the fabric in a milling liquor which is an organic solvent containing (i) a resin which imparts shrink-resistance dissolved therein (ii) water emulsified therein, (b) separating excess liquor from the fabric and (c) curing the resin constituent of the liquor remaining on the fabric. Water concentrations of 2 to 30% of the dry weight of the fabrics (a ratio of 1:50 to 1:3) are required and generally the mulling liquor contains a surface active emulsifying agent in an amount from 1 to 30 and preferably 2 to 20 grams per litre. Ideally suited for carrying out the process is a dry-cleaning machine where the fabric is tumbled in a rotating drum, the emulsion being formed in the drum either before or after the fabric is inserted and subjected to the tumbling action. The ratio (W/V) of fabric to solvent is usually 1:70 to 1:6 and preferably 1:10. The organic solvent is preferably a halogenated hydrocarbon. The resin should be insoluble in water and so is capable of being cross-linked with itself and/or with reactive centres on the keratinuous fibres. Examples of suitable resins are solvent-soluble acrylics, polybutadienes, carboxylated polybutadienes, silicones, melamine formaldehydes, poly (aminoamides) polyepoxides and polythiols. Preferred polythiols are those containing at least two -SH groups directly attached to aliphatic carbon atoms, especially the class of polythiol resins having at least two thiol groups per molecule and containing:-(a) a radical of a polyhydric alcohol, (b) bound to this radical at least two poly (oxyalkylene) chains, and (c) bound through oxygen atoms to carbon in the said poly (oxyalkylene) chains, at least two residues selected from the group consisting of an acyl radical of a thiol-containing aliphatic carboxylic acid or a residue, after removal of a hydroxyl group, of a thiol-containing aliphatic alcohol. Preferably the amount of resin applied to the fabric is 0.5 to 15% by weight of dry fabric and preferably 1 to 5%. A catalyst may be dissolved in the aqueous organic phase of the milling liquor in an amount from 0.001 to 10% by weight of the fabric. After separation of excess liquor the fabric is heated to 25 to 150C. The keratinous fibres may be blended with polyamides, polyesters, polyacrylonitriles, silk, cotton and regenerated cellulose.
[GB1327395A]
Patent IE-861495-L (IE)
Title: Measuring free ligand in biological fluids
IPC: G01N33/78
Filed: 1986-06-05
Abstract: The invention provides a method for measuring the concentration of free testosterone ligand in a biological fluid in the presence of bound ligand and endogenous binding proteins, without disturbing the equilibrium between free ligand and protein-bound ligand, which method comprises   (a) incubating, in the absence of salicylate, 2,4-dinitrophenol and 8-anilino-1-naphthalenesulfonic acid, a sample of the biological fluid with (i) a ligand analog tracer which, due to its chemical structure, does not bind to some of the endogenous binding proteins but does bind to at least one other endogenous binding protein, (ii) a concentration of a specific ligand binder having an affinity constant and selectivity for the free ligand such that the equilibrium between free ligand and protein-bound ligand is not disturbed and (iii) a concentration of sulfobromophthalein (SBP) that inhibits the binding of the ligand analog tracer to said at least one other endogenous binding protein sufficient to block reaction between the ligand analog tracer and said at least one other endogenous binding protein without displacing ligand from protein-bound ligand; (b) separating the ligand analog tracer bound to the specific ligand binder from unbound tracer; and (c) determining the concentration of free ligand in said biological fluid.
Patent IE-821851-L (IE)
Title: Spirothiazolidinyl piperazine derivatives
IPC: C07D277/60
Filed: 1982-07-30
Abstract: Piperazinyl derivatives containing a spiro-2,4-thiazolidinedione heterocyclic component with relatively selective psychotropic properties are disclosed. The compound 2-[4-[4-(7,9-dioxo-6-thia-8-azaspiro[4.4]nonan-8-yl)butyl]-1-piperazin yl]pyridine-3-carbonitrile which has selective anti-psychotic activity constitutes a typical embodiment of the invention.
[US4456756A]
Patent IE-881863-L (IE)
Title: A method and a plant for transport of hydrocarbons over a¹long distance from an offshore source of hydrocarbons
IPC: F17D1/00
Filed: 1988-06-20
Abstract: A method is disclosed for transport of hydrocarbons in a pipeline flow across large distances, from a first location at an offshore hydrocarbon reservoir to a second location. At said first location a liquid absorbent is provided in the form of a gas-poor hydrocarbon liquid flow. A flow of gas saturated hydrocarbon liquid and released associated hydrocarbon gas is supplied to the gas-poor liquid flow at said first location, the volume of gas-poor hydrocarbon liquid being selected so as to be sufficient for all released associated hydrocarbon gas to be absorbed by the gas-poor hydrocarbon liquid. Then the hydrocarbon liquid with absorbed hydrocarbon gas is transported to said second location. A plant for transport of hydrocarbons in a pipeline flow is also disclosed. The plant comprises an absorption chamber (6) at a first location. Absorption chamber (6) is connected to a well pipe (3). At a second location a separator plant (9) is provided. A first pipeline extends from the liquid portion of separator plant (9) to absorption chamber (6). A second pipeline (7) connects absorption chamber (6) with separator plant (9). In said first pipeline (10) the flowing medium can be pressurized by the aid of a high pressure pump (11).
[WO8810397A1]
Patent IE-801867-L (IE)
Title: Ultrafiltration and reverse osmosis device
IPC: B01D63/06
Filed: 1980-09-05
Abstract: An improved multi-tubular module is provided for use in ultrafiltration and reverse osmosis devices. Improved mechanical strength is achieved in the module by bonding the individual tubes (10) to each other at spaced intervals along their total length whereby lateral and axial movement of individual tubes (10) with respect to one another is elimin ated, resulting in a coherent monolith of tubes. Additionally, improved resistance to thermal cycling is imparted to the module by connecting the tube sheet or header (26) to the module shell (28) in a manner which allows for slight movement of the tube sheet (26) with respect to the module shell (28) and yet provides a device which can be easily sanitized or sterilized when used for food or drug applications.
[EP0025349A1]
Patent IE-832109-L (IE)
Title: 1-arylcyclobutylalkylamine compounds
IPC: C07D207/12
Filed: 1983-09-08
Abstract: Compounds of formula I <CHEM> in which n = 0 or 1; in which, when n = 0, R1 is H, an alkyl, a cycloalkyl, a cycloalkylmethyl, an alkenyl or, an alkynyl group a heterocyclic ring or an optionally substituted phenyl rig or when n = 1, R1, is H or an alkyl group; in which R2 and R3 and H or an alkyl group; in which A is a group of formula III -(CH2)x-W-(CH2)y- III in which W is an oxygen atom or a group of formula -S(O)m-, a group of formula -CR12R13-, a cycloalkylidene group or a cycloalkylene group, x is 0 or an integer from 1 to 5; y is 0 or an integer from 1 to 5. in which R4 is a carbocyclic ring, a heterocyclic ring, a cyano group, a carbamoyl group, an alkoxylcarbonyl group, an amido group, an acyloxy group, a hydroxy group, a thiol group, or a group of formula -OR20, -SR20, -SOR20 or SO2R20. in which R5, R6 and R7 and H, halo, trifluoromethyl, hydroxy, an alkyl group, an alkoxy or alkylthio group, phenyl or R5 and R6, together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring; in which R8 and R9 and H or an alkyl group containing 1 to 3 carbon atoms; and pharmaceutically acceptable salts thereof have utility in the treatment of depression. Processes for their preparation and compositions containing them are disclosed. 
[EP0111994A1]
Patent IE-832439-L (IE)
Title: Bursting disc pressure relief device
IPC: F16K17/16
Filed: 1983-10-17
Abstract: A bursting disc assembly comprises a generally tubular body provided with an external screw thread and, at one end of the body, a counterbore which forms an annular seat within the body to accommodate at least the peripheral regions of a preferably flat bursting disc; a bursting disc located on the seat and a plug with a longitudinal bore pushed into and a tight fit within the counterbore so as to hold the bursting disc in place, the plug being prevented from rotating with respect to the body by knurls which bite into the walls of the counterbore. In use, the assembly is screwed into the housing of a pressure relief device so that the free end of the plug bears against and forms a fluid-tight seal with an opening in the base of the housing and at the same time, the other end of the plug compresses the bursting disc against the seat so as to form fluid-tight seals between plug, bursting disc and seat.
[US4590957A]
Patent IE-852491-L (IE)
Title: Transdermal drug enhancement
IPC: A61L15/16
Filed: 1985-10-10
Abstract: A method of enhancing transdermal delivery of a pharmaceutically active drug from a transdermal delivery system as well as a transdermal delivery system capable of providing a desirable flow interface between the delivery system and the skin surface. The method involves pre-treating an area of skin with an anticholinergic agent in an amount sufficient to have a local antisecretory effect on the area treated, such amount being insufficient to cause systemic effects; and applying the transdermal delivery system to the pretreated area. The delivery system of the present invention is comprised of a carrier means, a pharmaceutically active drug and an anticholinergic agent. With both the method and the delivery system, the anticholinergic agent is preferably a quaternary ammonium salt which is itself transdermally delivered to the area beneath the delivery system in an amount sufficient to suppress perspiration in that area. The suppression of perspiration prevents the formation of an aqueous interface between the skin and delivery system which might prevent drug delivery.
[WO8602272A1]
Patent IE-802552-L (IE)
Title: Cephalosporins.
IPC: A61K31/546
Filed: 1980-12-05
Abstract: Derivatives of N-substituted thiazolyl oxy-imino-substituted cephalosporins, such as, for instance, the compound 7 beta -[2-(2-imino-3-hydroxy-4-thiazolinyl)-2-methoxy-imino-acetamino]-3-[(t etrazolo[1,5-b]pyridazin-6-yl)-thiomethyl]-3-cephem-4-carboxylic acid, are disclosed. The disclosed compounds have high anti-bacterial activity against Gram-positive and Gram-negative bacteria normally susceptible to cephalosporins.
[US4358448A]