baber/WOPTO huggingface dataset:
Patent AT-E247100-T1 (AT)
Inventor: BRYANT HENRY UHLMAN
IPC: A61K31/00
Filed: 1996-03-06
Granted: 2003-08-15
Abstract: The present invention provides a compound of formula I <CHEM> wherein R1 is H, OH, halo, OCO(C1-C6 alkyl), OCO(aryl), OSO2(C4-C6 alkyl), OCOO(C1-C6 alkyl), OCOO(aryl), OCONH(C1-C6 alkyl), or OCON(C1-C6 alkyl)2;     R2 is aryl, C1-C6 alkyl, C3-C6 cycloalkyl, or 4-cyclohexanol;     R3 is O(CH2)2 or O(CH2)3; R4 and R5 are optionally CO(CH2)2CH3, CO(CH2)3CH3, C1-C6 alkyl, or R4 and R5 combine to form, with the nitrogen to which they are attached, piperidine, morpholine, pyrrolidine, 3-methylpyrrolidine, 3,3-dimethylpyrrolidine, 3,4-dimethylpyrrolidine, azepine, or pipecoline;     R6 is  &rdurule&  C=CH2 , &rdurule& CH(C1-C5 alkyl),  &rdurule& CH(C2-C5 alkenyl),  &rdurule& C=CH(C1-C5 alkyl), &rdurule& CH(aryl),  &rdurule& C(OH)(C1-C5 alkyl),  &rdurule& C(OH) (C2-C5 alkenyl),  &rdurule& C(OH)aryl;  and pharmaceutically acceptable salts thereof. The present invention further provides pharmaceutical compositions containing compounds of formula I, optionally containing estrogen or progestin, and the use of such compounds alone, or in combination with estrogen or progestin, for alleviating the symptoms of post-menopausal syndrome, particularly osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer. As used herein, the term "progestin" includes compounds having progestational activity such as, for example, progesterone, norethylnodrel, nongestrel, megestrol acetate, norethindrone, and the like. The compounds of the present invention also are useful for inhibiting uterine fibroid disease and endometriosis in women and aortal smooth muscle cell proliferation, particularly restenosis, in humans.
Patent AT-E263149-T1 (AT)
Inventor: MURAOKA HIDEO
IPC: C07D207/12
Filed: 1999-09-07
Granted: 2004-04-15
Abstract: A method for producing pyrrolidine derivatives such as 3,4-epoxypyrrolodines and 3-pyrrolidols comprises oxidizing 3-pyrrolines with at least one peroxide in the presence of at least one acid. The 3-pyrrolines are obtainable by deriving cis-2-butene compounds from cis-2-butene-1,4-diols and performing a cyclization between the cis-2-butene derivatives and at least one primary amine. The method may be performed as a one-pot synthesis and may be performed as a continuous reaction.
Patent AT-E282711-T1 (AT)
Inventor: DONNELLY DAN
IPC: C12Q1/06
Filed: 1999-09-14
Granted: 2004-12-15
Abstract: In a method of calculating amounts of yeast for use in a process in order to ensure that the number of yeast cells used in the process is consistent, the sizes of the yeast cells to be used are measured and the average size calculated and this calculated average cell size is used together with viability data to calculate the amount of yeast to be used. <IMAGE>
Patent AT-E258715-T1 (AT)
Inventor: LAZARETH MICHEL
IPC: H01H71/16
Filed: 1999-05-31
Granted: 2004-02-15
Abstract: The differential release mechanism (9) may be actuated by a relay (16) and displacing a rod (19) between rest and activation positions. The starting point of the rod is arranged outside of the electromagnetic relay (7) and acts directly on the starting point tripping device (20) at the time of the occurrence of a differential defect. This same rod assures the resetting of the relay (16) after opening of the contacts.
Patent AT-E241062-T1 (AT)
Inventor: HANSEN BIRGITTE
IPC: E06B3/40
Filed: 1999-03-25
Granted: 2003-06-15
Abstract: The roof window has main frame and pivot sash which are covered by a flat U-shaped cover unit. The top portions (1,5) of the main frame and pivot sash are covered by a hood-like upper cover (32). An interior glazing profile (15) covers the upper edges (7,8) of each pivot sash facing the light admitting area. An exterior cover unit (11) covers the protruding portions (3,4) of each main frame. The upper and lower portions of cover unit overlapping with the glazing profile and exterior frame cover (11) are screwed to the lower portions of pivot sash unit and upper portion of main frame respectively. The lower cover (21) has a joggled connection portion (22) which is inserted into the upper cover (20) such that, when the window is opened, the lower cover swings unimpedently outwards with respect to the upper cover.
Patent AT-E253284-T1 (AT)
Inventor: VERKRUIJSSEN BARTEL JOHANNES
IPC: H04W84/02
Filed: 1999-03-10
Granted: 2003-11-15
Abstract: Communication system comprising one or more exchanges and a number of terminals (telephone sets, facsimile apparatuses, etc.) which each through one of the mentioned exchanges is able to communicate with at least one of the other terminals whereby a) the user of a calling terminal calls the number of its own exchange, transmits signals indicating that the terminal has to be called back by the exchange after which the connection is cut off, b) thereafter the exchange establishes a connection with the calling terminal, c) the user of the terminal transmits the number of a desired other terminal to the exchange, d) the exchange thereafter establishes the connection with the desired terminal, whereby at least the calling terminals can be connected partly through wireless communication paths with their own exchange and to comprise a buffer in which the number of the desired other terminal can be stored, and comprise a circuit which, after said number is keyed in by the user and is stored in the said buffer, performs the above-mentioned steps a) instead of the user, waits until the exchange reports again, retrieves the number from said buffer and transmits this number instead of the user to the exchange which will perform thereafter step d).
Patent AT-E473022-T1 (AT)
Inventor: ZIA MAJID
IPC: A61M1/02
Filed: 1999-03-19
Granted: 2010-07-15
Abstract: A biological fluid processing or fluid filtration system is provided having novel open and closed loop processing systems wherein the gases transferred into and out of the system during processing pass through a porous medium in upstream and/or downstream gas inlet or outlet housings or vents in a manner which precludes the fluid being processed or filtered from ever contacting the housings or vents. Each housing or vent is separated from the fluid by a column of gas in its respective transfer line. The upstream gas inlet housing or vent is in communication with the unfiltered biological fluid, and the downstream gas inlet housing or vent is in communication with the filtered biological fluid.
Patent AT-E246339-T1 (AT)
Inventor: DEVAULT GREEN JOHN-BRUCE
IPC: G01B21/30
Filed: 1999-05-05
Granted: 2003-08-15
Abstract: A sample support member for atomic force microscopy of intermolecular interactions includes a sample support base having a plurality of protrusions, each protrusion having an apical substrate region or tip that has been chemically modified by the immobilization thereon of a sample compound or of a linking compound that is capable of binding a sample compound. A reference compound support member has a surface region having at least one reference compound immobilized thereon. The relative position and orientation of the reference compound support member and the substrate support member are controlled to select a particular protrusion and to cause an interaction between a reference compound immobilized on the surface region of the free end of the cantilever and the sample compound immobilized on the apical substrate area of the selected protrusion. A physical parameter associated with the interaction between the reference compound and the sample compound can be measured.
Patent AT-E207697-T1 (AT)
Inventor: SALA ANDRE
IPC: A21C5/00
Filed: 1999-03-02
Granted: 2001-11-15
Abstract: The invention concerns an apparatus comprising a container (1) closed with a lid (6) storing the product to be dispensed, a cylinder communicating with the container (1) and whereof the bottom is provided with an outlet, a piston (12) traversed by at least one orifice (13), sliding in the cylinder, a check valve (25) mobile between positions opening and closing the orifice (13), said check valve (25) being urged by a spring towards its opening position, a dispensing nozzle communicating with the outlet and provided with a normally closed plug which opens by the effect of the pressure of the product contained in the cylinder, and means for actuating the piston from outside the container (1). The invention is useful for making pancakes.
Patent AT-E310269-T1 (AT)
Inventor: LEBKUCHNER BENNO
IPC: G05D23/13
Filed: 1999-09-03
Granted: 2005-12-15
Abstract: A mixing valve receives fluid from a first source and fluid from a second source and outputs a mixture of the fluids. The mixing valve includes a valve body including a first fluid inlet, a first fluid chamber, a second fluid inlet, a second fluid chamber, and a fluid outlet. The mixing valve further comprises a fluid flow regulator mounted within the housing, wherein a lower surface of the fluid flow regulator is disposed within the first fluid chamber and an upper surface of the fluid flow regulator is disposed within the second fluid chamber. The fluid flow regulator is mounted within the valve body in such a way as to permit movement of the fluid flow regulator along a longitudinal axis of the valve body. The fluid flow regulator includes a central hub which extends below the lower surface into the mixing chambr. A temperature-sensing device is mounted to the central hub of the fluid flow regulator and is constructed and arranged for sensing a temperature of fluid which flows from the mixing chamber to the outlet.
Patent AT-E269651-T1 (AT)
Inventor: SCHON GISELA
IPC: A47C9/00
Filed: 1999-10-19
Granted: 2004-07-15
Abstract: The seat incorporates devices which force at least one point of the seat surface (1) to move continuously and cyclically periodically in at least two movement directions, whereby the one period is greater, preferably twice as great, as the other period. The seat surface is movable around a variable rotary point (3). The seat surface in its angle of inclination is movable both in the seat direction and also laterally. Leg supports are movable with the seat surface and incorporate at least one lower leg support, preferably with a lateral support surface.
Patent AT-E304223-T1 (AT)
Inventor: HEINEMANN BERND
IPC: H01L21/331
Filed: 1999-12-08
Granted: 2005-09-15
Abstract: The aim of the invention is to provide for a bipolar transistor and a method for producing the same. Said bipolar transistor should have minimal base-emitter capacities and very good high frequency characteristics. The static characteristics, especially the base current ideality and the low frequency noise, of a bipolar transistor with weakly doped cap layer (116) should not significantly deteriorate and process complexity should not increase. According to the invention, the problem is solved by inserting a special doping profile in a cap layer (116) (cap doping) which has been produced epitaxially. A minimal base emitter capacity and very good high frequency characteristics can be obtained by means of said doping profile. At the same time, the efficiency of the generation/recombination active boundary surface between the cap layer (116) and the isolator (117) in the polysilicon overlapping area in the relevant working area of the transistor is reduced and the base current ideality is improved. The section at the base side in the cap layer (116) has a preferred thickness of between 20 nm and 70 nm and is only doped weakly, preferably less than 5.10<16 >cm<-3>. Said section is crucial for the good high frequency characteristics.
Patent DE-05744161-T1 (DE)
Title: Zusammensetzungen mit fluorsubstituierten olefinen
Inventor: SINGH RAJIV R
IPC: C09K5/04
Filed: 2005-04-29
Abstract: Wärmeübertragungszusammensetzung,
umfassend:  (a) mindestens ein Fluoralken der Formel I:  XCF z R 3-z  (I) wobei X
für einen
ungesättigten,
substituierten oder unsubstituierten C 2 -
oder C 3 -Alkylrest steht, R unabhängig voneinander
für Cl,
F, Br, I oder H steht und z für
1 bis 3 steht, mit einem Treibhauspotential (GWP) von höchstens
etwa 1000.
Patent DE-06709687-T1 (DE)
Title: Transportsystem
Inventor: HODGSON IAN
IPC: G01G19/03
Filed: 2006-02-09
Abstract: Transportsystem
zum Transportieren von Gegenständen
entlang eines Transportpfads, wobei das System viele Schieberelemente,
die an einem Steuermechanismus zum Bewegen der Schieberelemente
entlang des Transportpfads gekoppelt sind; eine Stützvorrichtung,
die sich entlang des Transportpfads zum Stützen der Gegenstände erstreckt,
die durch die Schieberelemente gedrückt werden; und ein Wiegesystem
aufweist, das ein Wiegelement umfasst, das auf einer Gewichtserfassungsvorrichtung
gestützt
ist, wobei das Wiegeelement dazu geeignet ist, einen Gegenstand
von der Stützvorrichtung
zu dem Wiegeelement und außer
Kontakt von den Schieberelementen zu transferieren.
Patent DE-33579-T1 (DE)
IPC: C12P1/00
Filed: 1981-01-07
Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
Patent DE-916741-T1 (DE)
Inventor: JODET GERARD
IPC: C21D9/573
Filed: 1998-10-06
Abstract: In an apparatus that rapidly cools heat treated metal strips with a recirculating nitrogen-hydrogen cooling gas mixture having a hydrogen content which ranges between 15%-50%, and a recirculation circuit for the gas mixture having a fan for creating a flow though recirculation ducts connected, through expandable compensator corrugations, upstream to at least one gas/water exchanger, a safety system operates with the exchanger. The safety system includes a housing having a main flow area upstream of the exchanger and into which recirculating cooling gas flows. A first register is interposed across the main flow area for selectively switching between open and closed states thereby passing or blocking flow through a major portion of the main flow area. At least one bypass flow area is defined within the housing and located adjacent the main flow area. A second register is interposed across the bypass flow area for selectively switching between open and closed states thereby passing or blocking flow through the bypass area. Respective sensors react to a break in the strip or the corrugation, or an interruption of power, and actuators rapidly respond to a plurality of dangerous conditions for activating the sensing means and for switching the first and second registers in accordance with the particular dangerous conditions.
Patent ES-2136045-T1 (ES)
Title: Dispositivo relacionado con herramientas de alta velocidad.
Inventor: LIND BJORN
IPC: B23Q1/76
Filed: 1997-08-28
Abstract: UNA HERRAMIENTA FRESADORA O TALADRADORA DE ALTA VELOCIDAD INCLUYE UNA PIEZA CORTANTE EN FORMA DE CABEZA CORTANTE (24) Y UN MEDIO DE FIJACION (27) DISPUESTO EN EL EXTREMO DE LA HERRAMIENTA ALEJADO DE LA CABEZA CORTANTE (24). AL MENOS PARTE DE LA HERRAMIENTA FORMA UNA SUPERFICIE DE APOYO (26) PARA UN COJINETE QUE ABSORBE LAS FUERZAS DE CORTE QUE ACTUAN RADIALMENTE.
Patent CY-1110903-T1 (CY)
Inventor: BANULS BOLTA ROSA
IPC: A47L13/20
Filed: 2010-09-01
Abstract: The mop for cleaning utensils has a bundle of cords formed from synthetic micro fibres. The cords are held together by a band or headpieces. The micro fibres can form threads joined by tangling or welding. Each cord can be formed by two or more twisted threads, or braided threads.
Patent CY-1117092-T1 (CY)
Title: Μοτιβα της οικογενειας παγκρεατικων πολυπεπτιδιων, πολυπεπτιδια και μεθοδοι που τα περιλαμβανουν
Inventor: LEVY ODILE ESTHER
IPC: A61K38/17
Filed: 2015-10-27
Abstract: Η παρούσα εφεύρεση προσφέρει νέα πολυπεπτίδια της Οικογένειας των Παγκρεατικών Πολυπεπτιδίων ("PPF") και μεθόδους για τη χρήση τους.
Patent CY-1117521-T1 (CY)
Inventor: VAN OMMEN GARRIT-JAN BOUDEWIJN
IPC: A61K48/00
Filed: 2016-03-10
Abstract: The present invention provides a method for at least in part decreasing the production of an aberrant protein in a cell, said cell comprising pre-mRNA comprising exons coding for said protein, by inducing so-called exon skipping in said cell. Exon-skipping results in mature mRNA that does not contain the skipped exon which leads to an altered product if said exon codes for amino acids. Exon skipping is performed by providing a cell with an agent capable of specifically inhibiting an exon inclusion signal, for instance an exon recognition sequence, of said exon. Said exon inclusion signal can be interfered with by a nucleic acid comprising complementarity to a part of said exon. Said nucleic acid, which is also herewith provided, can be used for the preparation of a medicament, for instance for the treatment of an inherited disease.
Patent CY-1119409-T1 (CY)
Title: Κουτι συνδεσης καλωδιων το οποιο παρεχει πολλαπλους τροπους για την υδατοστεγανωση κυριων καλωδιων
Inventor: HSING CHIH KUANG
IPC: H02G15/06
Filed: 2017-02-16
Abstract: Ένα περίβλημα σύνδεσης καλωδίων (406), το οποίο παρέχει πολλαπλές μεθόδους υδατοστεγάνωσης κυρίως καλωδίων περιλαμβάνει ένα προστατευτικό κάλυμμα (402) και τουλάχιστον μία επιφάνεια (403) εισόδου -εξόδου καλωδίου η οποία έχει τουλάχιστον τρείς κοίλες σωληνοειδείς στήλες, όπου μία στήλη (404) επιτρέπει να υδατοστεγανώνονται δύο κυρίως καλώδια μέσω ενός θερμοσυρρικνούμενου μανικιού ώστε να εισέρχονται και να εξέρχονται από το εν λόγω περίβλημα (401), ενώ εκάστη από τις άλλες δύο στήλες (405Α, 405Β) επιτρέπει σε ένα κυρίως καλώδιο να υδατοστεγανώνεται μέσω ελαστικού υλικού ώστε να εισέρχεται και να εξέρχεται από το εν λόγω περίβλημα σύνδεσης καλωδίων (401).
Patent CY-1120898-T1 (CY)
Title: Μεθοδος αποκωδικοποιησης βιντεο με τη χρηση μοναδας μετασχηματισμου δομης δενδρου μεταβλητης
Inventor: LEE TAMMY
IPC: H04N19/119
Filed: 2018-11-26
Abstract: Παρέχεται μία μέθοδος κωδικοποίησης βίντεο, ώστε να κωδικοποιηθεί μία τρέχουσα περιοχή ενός βίντεο, με την πραγματοποίηση μετασχηματισμού στην τρέχουσα περιοχή με τη χρήση μονάδων μετασχηματισμού σε μία δομή δένδρου μεταβλητής, οι οποίες καθορίζονται από μεταξύ μονάδων μετασχηματισμού που διαμερίζονται ιεραρχικά από μία βασική μονάδα μετασχηματισμού σε σχέση με την τρέχουσα περιοχή και οι οποίες δημιουργούνται βάσει ενός μέγιστου επιπέδου διαμερισμού μίας μονάδας μετασχηματισμού˙ και εξάγοντας κωδικοποιημένα δεδομένα της τρέχουσας περιοχής, πληροφορίες για έναν τρόπο κωδικοποίησης και πληροφορίες ιεραρχικής δομής μονάδας μετασχηματισμού που περιλαμβάνουν πληροφορίες μέγιστου μεγέθους και πληροφορίες ελάχιστου μεγέθους της μονάδας μετασχηματισμού σε σχέση με το βίντεο.
Patent CY-1125068-T1 (CY)
Title: Ενωσεις τετραϋποκατεστημενου αλκενιου και χρηση αυτων
Inventor: BOCK MARK
IPC: A61K31/4439
Filed: 2021-11-08
Abstract: Στο παρόν έγγραφο γνωστοποιούνται ενώσεις ή φαρμακευτικώς αποδεκτά άλατα αυτών και μέθοδοι χρήσης των ενώσεων για τη θεραπευτική αντιμετώπιση του καρκίνου του μαστού με τη χορήγηση σε ένα υποκείμενο που χρήζει αυτής, μιας θεραπευτικώς δραστικής ποσότητας των ενώσεων ή των φαρμακευτικώς αποδεκτών αλάτων αυτών. Ο καρκίνος του μαστού δύναται να είναι καρκίνος του μαστού θετικός σε ER και/ή το υποκείμενο που χρήζει θεραπευτικής αντιμετώπισης δύναται να εκφράζει μια μεταλλακτή πρωτεΐνη ER-α.
Patent HR-P20100007-T1 (HR)
Inventor: SMITH-SWINTOSKY VIRGINIA L
IPC: A61K31/353
Filed: 2010-01-07
Abstract: Spoj formule (I) ili njegova farmaceutski prihvatljiva sol za upotrebu kod liječenja boli, naznačen time, da su: R1 i R2 svaki neovisno izabrani iz skupine koja se sastoji od vodika i nižeg alkila; R4 je izabran iz skupine koja se sastoji od vodika i nižeg alkila; a je cijeli broj od 1 do 2; je izabran iz skupine koja se sastoji odigdje je b cijeli broj od 0 do 4; i gdje je c cijeli broj od 0 do 2; svaki R5 je neovisno izabran iz skupine koja se sastoji od halogena, nižeg alkila i nitro; pri čemu je osigurano kada jeilitada je a 1, gdje se termin niži alkil upućuje na ugljikovodični lanac sastavljen od 1-4 ugljikova atoma. Patent sadrži još 10 patentnih zahtjeva.
Patent HR-P20100149-T1 (HR)
Inventor: BANHOLZER ROLF
IPC: C07D451/10
Filed: 2010-03-16
Abstract: Postupak priprave novih tiotropijevih soli formule 1 gdje X- označava anion, naznačen time, da tiotropijeva sol formule 2gdjeY- označava anion različit od X- izabran iz skupine koju čine halid, C1-C10-alkilsulfonat, C1-C10-alkilsulfat, C6-C10-arilsulfonat, reagira u prikladnom otapalu s izvorom iona Kat-X gdje Kat označava kation i X može imati gore navedena značenja. Patent sadrži još 6 patentnih zahtjeva.
Patent SI-1390022-T1 (SI)
Title: USE OF 4-(2-FLUOROPHENYL)-6-METHYL-2-(1-PIPERAZINYL)THIENO 2,3-D?æPYRIMIDINE FOR THE TREATMENT OF PAIN
Inventor: BARDSLEY HAZEL JUDITH
IPC: A61P25/00
Filed: 2002-05-21
Abstract: 4-(2-Fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine or a salt thereof is useful for the treatment of pain.
Patent SI-1516626-T1 (SI)
Title: A Teicoplanin composition with improved antibiotic activity
Inventor: SUHR-JESSEN TRINE
IPC: A61K38/14
Filed: 2003-09-17
Abstract: A Teicoplanin composition with improved antibiotic activity. <IMAGE>
Patent SI-1613453-T1 (SI)
Title: Method and apparatus for producing a shaft bottom and a set of moulding elements
Inventor: SCHLUSSELBAUER JOHANN
IPC: B28B7/16
Filed: 2004-03-26
Abstract: A method for producing a concrete shaft bottom which comprises a drain having a defined shape. Concrete is introduced into a bottom mold that comprises a mold jacket and a mold bottom. On the mold bottom, a molded body forming the negative shape of the drain is disposed to configure the drain. The invention allows for the inexpensive and mechanized production of a shaft bottom having an individual drain. For this purpose, the molded body is configured from at least one molded piece that is fixed on the bottom mold, especially on the mold bottom. The molded piece is adapted to the dimensions of the defined shape of the drain and is removed from the shaft bottom once or while the formwork is dismantled from the shaft bottom.
Patent SI-1916176-T1 (SI)
Title: Car steering wheel electromechanical booster
Inventor: SHEVCHENKO ALEKSANDR FEDOROVICH
IPC: B62D5/04
Filed: 2006-08-14
Abstract: The invention relates to car control means. The stator of an electric motor is provided with a magnet core comprising pronounced poles and a rotor comprising n-2 poles embodied in the form of permanent magnets. The stator three-phase winding is provided with coils placed in the six equal alternating phase areas in such a way that one area is assigned to one pole and with several coils belonging to one phase in each phase area. The winding coils in the areas belonging to one phase are connected in a parallel aiding configuration. The steering wheel booster body is provided with input and output shafts which are interconnected with the aid of a torsion bar embodied in the form of a torque sensor sensing element and are linked with the sheering wheel and sheering mechanism by the other ends thereof. The electric motor rotor is mounted on the output shaft. The inventive device also comprises a controllable source for supplying the stator winding, a rotor position sensor and a control unit which is connected to the outputs of the torque and rotor position sensors by the inputs thereof and to the control input of the supply source by the output thereof. Said invention excludes the transmission of an outside disturbance torque to the steering wheel and makes it possible to improve the producibility of the electric motor and the steering wheel buster and to increase the useful properties thereof.
Patent SI-2168585-T1 (SI)
Title: Pharmaceutical compositions of a neuroactive steroid and uses thereof
Inventor: WOODWARD RICHARD M
IPC: A61K9/00
Filed: 2006-06-09
Abstract: The present invention relates to a pharmaceutical composition, comprising 3±-hydroxy-3²-methoxymethyl-21-(1'-imidazolyl)-5a-pregnan-20-one or a pharmaceutically-acceptable salt or solvate thereof, and one or more pharmaceutically-acceptable excipients, wherein the composition provides steady state plasma levels of 3±-hydroxy-3²-methoxymethyl-21-(1'-imidazolyl)-5±-pregnan-20-one in a range of from 5 ng/mL to 500 ng/mL for a duration of from 6 h to 24 h following administration.