baber/WOPTO huggingface dataset:
Patent DE-69023335-D1 (DE)
Inventor: KAJIHARA AKIRO - -
IPC: C07D405/14
Filed: 1990-03-08
Granted: 1995-12-07
Abstract: This invention relates to a sulfonamide derivative of general formula (I) and an antiasthmatic having a bronchodilator activity and containing said derivative as the active ingredient (I), wherein X represents a quinoline residue of formula (II) or an isoquinoline residue of formula (III) (wherein R<1> represents a hydrogen or halogen atom, or a lower alkyl or lower alkoxy group, and R<2> represents a hydrogen atom or a hydroxy group); and when X is a quinoline residue (II), n is 0 or 1 provided that when n is 0, R<4> represents an (un)substituted diazacycloalkyl group, while when n is 1, R<3> represents a hydrogen atom or a lower alkyl group and R<4> represents an (un)substituted aralkylamino group or an (un)substituted diazacycloalkyl group; or when X is an isoquinoline residue (III), n is 1, R<3> represents a hydrogen atom or a lower alkyl group, and R<4> represents a 3,4-methylene-dioxyphenethylamino group, a 3,4-methylenedioxy-benzylamino group or an (un)substituted diazacycloalkyl group, provided that when R<4> is an (un)substituted diazacycloalkyl group, said diazacycloalkyl group is bonded to the main chain at the nitrogen atom of said group.
Patent DE-69106189-D1 (DE)
Inventor: BARTON JOHN EDWARD DUNCAN
IPC: C07D401/12
Filed: 1991-02-06
Granted: 1995-02-09
Abstract: A herbicidal compound of formula (I) : <CHEM>  or N-oxide or quaternised derivative thereof; in which the dotted lines indicate the presence of two double bonds arranged so as to form a fused hetero-aromatic ring system;  Ar is an optionally substituted aryl or heterocyclic ring system;  W is O or NR<1>  where R<1> is H or lower alkyl; A, B, D are independently selected from N, NR<2>, N-E, CR<6>, C-E or C(R<6>)E;  wherein E is: <CHEM> provided 2 of A, B and D are N, NR<2> or N-E and at least one of A, B or D carries a group E;  where R<2> is H, OR<7>, CN, COOR<8>, alkyl or haloalkyl; R<3> and R<4> are independently selected from H, optionally substituted alkyl, alkenyl or alkynyl, halogen, NR<9>R<1><0>, or R<3> and R<4> together with the carbon to which they are attached form an optionally substituted alkenyl or cycloalkyl group; R<5> is CO2R<1><1>, CN, COR<1><1>, CH2OR<1><1>, CH(OH)R<1><1>, CH(OR<1><1>)R<1><2>, CSNH2, COSR<1><1>, CSOR<1><1>, CONHSO2R<1><1>, CONR<1><3>R<1><4>, CONHNR<1><3>R<1><4>, CONHN<+>R<1><3>R<1><4>R<1><5> Y<->, CO2<->M<+> or COON=CR<1><3>R<1><4>;  X is (CH2)n, CH=CH, CH(OR<1><6>)CH2 or COCH2;  where n is O, 1 or 2;  M<+> is an agriculturally acceptable cation;  Y<-> is an agriculturally acceptable anion;  R<6> is H, halogen, OR<7>, CN, COOR<8>, alkyl or haloalkyl;  R<7> and R<8> are independently H or lower alkyl; R<1><1>, R<1><2> and R<1><6> are independently selected from H or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; and R<9>, R<1><0>, R<1><3>, R<1><4> and R<1><5> are independently selected from H or an optionally substituted alkyl, alkenyl, alkynyl or aryl group or any two of R<9>, R<1><0>, R<1><3>, R<1><4> and R<1><5> together with the atom to which they are attached form a cycloalkyl or heterocyclic ring providing that the compound is other than 5-(2,4-dichlorophenoxy)indazol-1-ylacetic acid or its methyl ester. Process for the preparation of these compounds and compositions containing them are also described.
Patent DE-69113604-D1 (DE)
Inventor: KONNO FUJIKO
IPC: C07D215/56
Filed: 1991-07-17
Granted: 1995-11-09
Abstract: A quinolonecarboxylic acid derivative represented by general formula (1), its salt and an antibacterial agent containing the same as the active ingredient, wherein R<1> represents hydrogen, alkyl, aralkyl or an ester residue which is hydrolyzable in vivo; R<2> represents hydrogen or amino which may be substituted with one or two lower alkyl groups; X represents hydrogen or halogen; Y represents CH2, O, S, SO, SO2 or NR<3>, wherein R<3> represents hydrogen or lower alkyl; and Z represents an oxygen atom or two hydrogen atoms. This compound develops a potent antibacterial activity particularly against gram-positive bacteria, so that it is useful in preventing and treating various infectious diseases clinically. <CHEM>
Patent DE-69120318-D1 (DE)
Inventor: SHIBATANI TAKEJI
IPC: C12N9/18
Filed: 1991-03-06
Granted: 1996-07-25
Abstract: A novel esterase which is derived from Serratia marcescens is disclosed. Said esterase has the following physico-chemical properties and enzymatic charactaristics: (1) Activity; it (i.e., said esterase) hydrolyzes an ester bond of organic carboxylates, (2) Substrate specificity; it acts on alkyl esters of organic carboxylic acids, triglycerides or thiol esters, (3) Optimum pH; its optimum pH is 7.5 - 9.0 when the hydrolysis is carried out by using olive oil as the substrate, (4) pH stability; it is stable at pH 5.0 - 9.0 when it is stored at 30  DEG C for one hour, (5) Optimum temperature; its optimum temperature is 40 - 50 DEG C when the hydrolysis is carried out by using olive oil as the substrate, (6) Heat stability; it is stable at a temperature of not higher than 50 DEG C when it is stored at pH 8.0 for 30 minutes, (7) Molecular weight; 62, 000 +/- 2,000 (SDS-polyacrylamide gel electrophoresis), (8) Isoelectric point; 4.6 +/- 0.1, (9) Effect of metal ions; it is activated in the presence of 1 mM calcium ion, and inhibited in the presence of 1 mM cobalt ion, nickel ion, iron ion or ethylenediaminetetraacetic acid. Said esterase can widely be applied for organic synthetic reactions.
Patent DE-69122864-D1 (DE)
Title: Beta-zell-antigen
Inventor: ROEP BART
IPC: C12N5/08
Filed: 1991-05-06
Granted: 1996-11-28
Abstract: The invention provides a purified human 38 kD beta cell antigen consisting of an intrinsic transmembrane protein of insulin secretory granules of beta cells lying in pancreatic islets of Langerhans, which protein contains an epitope recognized by T cell clone 1C6 (ECACC No. 1C6 90050301). The antigen may be used to diagnose diabetes in a patient.
Patent DE-69125276-D1 (DE)
Inventor: BRESSLER DAVID
IPC: B41N10/00
Filed: 1991-04-25
Granted: 1997-04-24
Abstract: A printing medium or image carrier for application to a printing apparatus or substrate which comprises a plastic composition which is applied to a printing substrate to form a plastic coating covering the substrate, which plastic coating is engraved to provide a printing medium. Preferred plastic compositions are those including epoxide resins such as cycloaliphatic epoxide resins, reaction products of epichlorohydrin and bisphenol A, bisphenol A epoxy resins modified with cresol novolac(s), epoxy-novolac resins, and epoxy-novolac based vinyl esters. The present invention provides for an effective rotogravure printing medium without the use and/or disposal of hazardous chemicals.
Patent DE-69131422-D1 (DE)
Inventor: ECKER DAVID
IPC: C07H21/04
Filed: 1991-04-22
Granted: 1999-08-12
Abstract: Methods for modulating the expression of the HIV +E,uns tat+EE  gene are disclosed comprising contacting tat RNA with oligonucleotide or oligonucleotide analog which can bind with at least a portions of the RNA. In accordance with the preferred embodiments, oligonucleotides or oligonucleotide analogs are designed to bind to portions of the tat RNA which are of significance to the expression of the gene coding for said RNA. In accordance with a preferred embodiment, methods of treatment of human immunodeficiency virus are disclosed.
Patent DE-69132119-D1 (DE)
Inventor: VAN DAELE GEORGES HENRI PAUL
IPC: C07D405/12
Filed: 1991-02-22
Granted: 2000-05-25
Abstract: Benzamide piperidinyl cpds. of formula (I) and their salts N-oxides and isomers are new. A = CH2-CH2-, -CH2-CH2-CH2- or -(CH2)4- where 1 or 2 H of these radicals may be replaced by 1-6C alkyl. R1 = H or halo. R2 = H, NH2, mono- or di(1-6C alkyl)amino or 1-6C alkylcarbonylamino. R3 = H or 1-6C alkyl. L = 3-6C cycloalkyl; 5-6C cycloalkanone, 3-6C alkenyl (opt. substd. with aryl), -Alk-R4, -Alk-X-R5, -Alk-Y-COOR7 or -Alk-Y-CONR9R10. Alk = 1-6C alkanediyl. R4 = H, CN, 1-6C alkylsulphonylamino, 3-6C cycloalkyl, 5-6C cycloalkanone, aryl, di(aryl)methyl or Het. R5 = H, 1-6Calkyl, hydroxy-1-6C alkyl, 3-6C cycloalkyl, aryl or Het. X = O, S, SO2 or NR6. R6 = H, 1-6C alkyl or aryl. R7 = H, 1-6C alkyl, 3-6C cycloalkyl, aryl aryl-(1-6C alkyl) di(aryl)methyl, 1-6C alkyloxy or OH. Y = NR8 or a direct bond. R8 = H, 1-6C alkyl or aryl. R9, R10 = independently H, 1-6C alkyl, 3-6C cycloalkyl, aryl or aryl-1-6C alkyl, or R9 and R10 together form an opt. substd. pyrrolidinyl piperidinyl, piperazinyl or 4-morpholinyl radical. Aryl = opt. substd. phenyl. Het = a five or six-membered heterocyclic with 1,2,3 or 4, of S, S or N. (I) are new when L = H. 3 cpds. are specifically claimed e.g. 5-amino-6-chloro-3,4-dihydro-N- (1-tetrahydro-2-furanyl)- methyl)-4-piperidinyl)-2H-1 -benzopyran-8-carboxamide.
Patent DE-69203863-D1 (DE)
Inventor: BERGLUND KURT
IPC: B29L22/00
Filed: 1992-05-22
Granted: 1995-09-07
Abstract: Glass-fibre reinforced plastic tank, for example for liquid petroleum gas under high pressure, compressed air for air brakes or for storage of acetylene. The tank is composed of two halves (10, 12), the open ends of which are conically bevelled to form a male end (20) and a female end (22), which are joined to each other by an adhesive. The reinforcement in the outer and inner layers of the halves contains essentially longitudinal glass-fibre strands and the intermediate layer contains essentially transverse glass-fibre strands. In the half with the male end (20), the longitudinal glass-fibre strands in the inner layer (35) are densely located adjacent to each other, while the longitudinal glass-fibre strands in the outer layer lie in separate groups (30) of densely arranged glass-fibre strands with the predetermined spacing between the groups to form channel-shaped spaces (31). In the half with the female end (22), the order is reverse. In order to store acetylene, a pre-fabricated absorbent body of porous material is enclosed in the tank when the tank halves are glued together.
Patent DE-69226646-D1 (DE)
Inventor: EPENETOS AGAMEMNON ANTONIOU IC
IPC: A61K51/00
Filed: 1992-11-10
Granted: 1998-09-17
Abstract: A compound comprising a means to direct the compound to a nucleic acid within a cell and a radioactive moiety capable of destroying adjacent biological matter. It is preferred that the means to direct the compound comprise an antisense oligonucleotide. The antisense oligonucleotide may be complementary to DNA or RNA specifically forming part of a gene for the mutant ras protein, the mutant p53 protein, the bcr ab1 protein or an HIV (human immunodeficiency virus) protein, for example the HIV gag, pol, env or sor gene products. The compound may additionally comprise a targeting portion to target the compound to a desired cell type, for example it may comprise an MAb or part thereof specific for a tumour-specific or virus-specific antigen.
Patent DE-69301327-D1 (DE)
Inventor: CROSSDALE GARRY WILLIAM
IPC: B67C3/28
Filed: 1993-04-02
Granted: 1996-02-29
Abstract: The application describes a container which is adapted for suspension by its upper region below a filling head (3) of a dispenser, the container being characterized by register means (348) on a side wall thereof for interengaging with complementary register means (34) on a container support of the dispenser, registration of the register means allowing for alignment of the container below the filling head for filling of the container. The register means can comprise a number of pins or recesses in the side wall of the container for registration with complementary recesses or pins on the container support of the dispenser. <IMAGE>
Patent DE-69306835-D1 (DE)
Inventor: JOHANSSON LENNART
IPC: B65G1/04
Filed: 1993-03-10
Granted: 1997-02-06
Abstract: A materials handling system includes a railbound storage crane for transporting goods in storage corridors, and a transfer carriage (30) for moving the crane transversely between two storage corridors. The system also includes a transfer carriage drive means and the transfer carriage includes a carrier frame (32) for supporting and stabilizing the crane during its movement between the storage corridors. The drive means (17, 50) is mounted on the crane and includes a motor-driven wheel (51) which abuts a carriage support pad (39) for forward driving of the transport carriage. The crane conveniently includes means (53, 54) for moving the drive wheel (51) vertically between a raised, first position and a lowered, second position, wherein the drive wheel occupies the first position when the crane is driven in the storage corridors and to and from the transfer carriage, and occupies the second position when driving the transfer carriage forwards. <IMAGE>
Patent DE-69315827-D1 (DE)
Inventor: PIDGEON CHARLES
IPC: C07F9/117
Filed: 1993-04-16
Granted: 1998-01-29
Abstract: This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the formula:   <IMAGE>   or pharmaceutically acceptable salts thereof wherein one of R1 and R2 is hydrogen and the other is hydrogen, a hydrocarbyl fatty acid acyl group having 4-26 carbon atoms or a hydrocarbyl heteroatom fatty acid acyl group having 3-25 carbon atoms, or   <IMAGE>   and R is a naturally occurring polar head group characteristic of a glycerophospholipid isolated from endogenous sources; R3 is hydrogen or lower alkyl and R4 is hydrogen, hydrocarbyl containing from 1-18 carbon atoms in a principal chain and up to a total of 23 carbon atoms, said principal chain may contain 1-5 double bonds or 1-2 triple bonds; phenyl which may be unsubstituted or substituted with lower alkyl; naphthyl which may be unsubstituted or substituted with lower alkoxy; or R5ZR6; Z is O or S; R5 and R6 are independently a hydrocarbyl chain containing from 1-18 carbon atoms in the principal chain and up to a total of 23 carbon atoms, said chain may be completely saturated or may contain 1-5 double bonds or 1-2 triple bonds; and the sum of the carbon atoms in R3 and R4 does not exceed 23. This invention also relates to the compounds prepared therefrom as well as the use of the compounds to treat diseases in animals.
Patent DE-69318632-D1 (DE)
Inventor: JONES ROBERT
IPC: G01N15/02
Filed: 1993-02-11
Granted: 1998-06-25
Abstract: The invention concerns a method of and apparatus for measuring particles in a fluid medium in which the particles are moved relative to a structured light field preferably produced by a multi-facet laser light source. Light scattered by the particles is detected to generate an output signal which is analysed to give an indication either of particle size or particle velocity.
Patent DE-69319500-D1 (DE)
Inventor: ROBB JOHN
IPC: C08F292/00
Filed: 1993-05-06
Granted: 1998-08-13
Abstract: A novel inorganic particulate powder coated with an organic polymer is claimed. The product is obtainable by dispersing in water inorganic particles at a pH higher than their isoelectric point in the presence of a polymeric polybasic acid as a dispersing agent to produce particles having a modified isoelectric point. The pH of the dispersion is then adjusted to a value below 9 but above the modified isoelectric point and an ethylenically unsaturated monomer is polymerised in the presence of the dispersion so as to coat the inorganic particles with polymerised monomer. A method for forming the particles is also claimed. The particles prepared by the method have been shown to be uniformly and discretely coated with an organic polymeric coating and can be used in many applications where it is desired to disperse inorganic particles in organic media such as paints, inks and plastics compositions.
Patent DE-69325654-D1 (DE)
Inventor: POEYHOENEN PETRI
IPC: H04B1/69
Filed: 1993-05-06
Granted: 1999-08-19
Abstract: The invention relates to a method of increasing interference diversity in an FDMA/TDMA-based cellular system, in which system a transmission channel of the system between a mobile station (12) and a base station (11) is realized as a burst in a time slot of a TDMA frame (30) of a carrier of the base station. According to the invention, frequency hopping is used in a first part of the base stations (11) of the system, and interference diversity is increased further in such a way that additionally, in a second part of the base stations (11) of the system, at least one transmission channel uses at least two different time slots of a TDMA frame in sequential TDMA frames (30) in accordance with a predetermined repeated sequence, and that the sequences used by the separate base stations (11) are mutually coordinated in such a manner that at least the sequences used by the cells situated within the range of influence of each other are mutually sufficiently uncorrelated. The invention relates further to a cellular system according to the method.
Patent DE-69328910-D1 (DE)
Inventor: BOLLAG WERNER
IPC: A61K31/203
Filed: 1993-01-11
Granted: 2000-08-03
Abstract: 9-cis retinoic acid, its salts and esters can be used in the treatment of malignant and premalignant epithelial lesions, skin photodamage, disorders caused by increased sebum production, and psoriasis.
Patent DE-69332445-D1 (DE)
Inventor: REILLY DAVID M
IPC: A61M5/145
Filed: 1993-07-21
Granted: 2002-11-28
Abstract: A front-loading syringe which comprises a movable plunger for injecting liquid contrast media, is rotatably mountable on a front wall of an injector housing with an interference fit and in sealed relationship with respect thereto, with or without a pressure jacket, by a first-quick release mechanism. At the same time, the plunger is connected to an injector drive mechanism by a second readily releasable mechanism. During the mounting operation, a sensor reads injection information from an indicator device on the syringe and feeds it to an injector control. An audible-and-tactile indicating mechanism also is activated when the syringe is essentially in the desired mounted position. The syringe may include reinforcing ribs which also function as volumetric gradations, and liquid media presence-or-absence indicating dots which appear circular against a liquid media background and oval-shaped against an air background. An injection end of the syringe comprises an injector portion of reduced diameter inside a screw-threaded attachment portion of larger diameter, and may include loop-shaped reinforcing handle portions.
Patent DE-69334028-D1 (DE)
Inventor: OHNO TSUNEYA
IPC: C12Q1/68
Filed: 1993-07-07
Granted: 2006-07-06
Abstract: A probe for diagnosing infectious diseases in which the probe comprises the base sequence set out in SEQ. ID. No. 7 and specifically reacts with DNA of Staphylococcus epidermidis.
Patent DE-69400361-D1 (DE)
Inventor: INOUE MASATSUGU
IPC: H01J29/07
Filed: 1994-02-10
Granted: 1996-09-19
Abstract: A color cathode-ray tube includes a curved shadow mask (25) formed having a number of apertures and a substantially rectangular effective surface facing the inner surface of a panel (22). The effective surface of the shadow mask has a center through which the tube axis passes, a horizontal axis passing through the center and at right angles to the tube axis, and a vertical axis extending and at right angles to the tube axis and the horizontal axis. The effective surface of the shadow mask is formed so that, in the region located on the horizontal axis, the radius of curvature in the direction of the horizontal axis of the surface is larger than the radius of curvature in the direction of the vertical axis of the surface in a region substantially halfway between the center of the surface and a horizontal end of the surface, and so that, in the region located on the horizontal axis, the horizontal radius of curvature is smaller than the vertical radius of curvature in a region near the horizontal end portion. <IMAGE>
Patent DE-69407892-D1 (DE)
Inventor: SOUKUP VACLAV DIPL ING
IPC: E06B7/00
Filed: 1994-07-27
Granted: 1998-02-19
Abstract: A device for preventing from insect penetration through a window with swinging or pivoted window leaf (2) comprises insect net being arranged in a peripheral frame (6) which is disposed before a window frame (1) and fastened to an outer lamella member of a group (8) of lamella members surrounding a periphery of the window frame (1). Said group (8) of the tipping lamella members comprises an outer covering lamella (12), at least one distance lamella (11) and a fastening lamella (9) which are made as rectangular frames from planar lamellic strips and which are attached on two corners thereof to pivots (10), wherein fan-like spreading of the lamella members is restricted by folded seams (13) formed on edges of the lamella strips. <IMAGE>
Patent DE-69408111-D1 (DE)
Inventor: SMATI ABDELLATIF
IPC: B01D21/00
Filed: 1994-11-18
Granted: 1998-02-26
Abstract: Clarifier especially for liquid-treatment plants, consisting of a clarification tank fed with liquid from a feed channel and of a spillway, characterised in that it comprises a liquid-distribution system consisting of a plurality of calibrated openings (16, 16') made respectively in partitions (18) of liquid-entry chambers (20) fed from the said spillway (14) so that each opening receives a determined fraction of the liquid throughput, the said openings being arranged quincuncially in at least two horizontal rows. <IMAGE>
Patent DE-69408479-D1 (DE)
Inventor: LOGAN ERNEST FERGUS
IPC: G09F3/02
Filed: 1994-11-16
Granted: 1998-03-12
Abstract: A label, for identifying a cow whose milk should not be sold, comprising a strap having at its ends fastening means for securing the ends together with the strap tightly encircling the tail or leg of a cow, the strap having attached to its edge(s) a plurality of tear off tabs (16).
Patent DE-69414108-D1 (DE)
Inventor: EISENBERG ALAN
IPC: G16H50/30
Filed: 1994-04-29
Granted: 1998-11-26
Abstract: A system and method for assessing the medical risk of a given outcome for a patient comprises obtaining test data from a given patient corresponding to at least one test marker for predicting the medical risk of a given outcome and obtaining at least one variable relating to the given patient and transforming the test data with the variable to produce transformed data for each test markers. A database of transformed data from previously assessed patients is provided and mean and standard deviation values are determined from the database in accordance with the actual occurrence of the given outcome for previously assessed patients. The transformed data is compared with the mean and standard deviation values to assess the likelihood of the given outcome for the given patient and the database is updated with the actual occurrence for the given patient, whereby the determined mean and standard deviation will be adjusted.
Patent DE-69427098-D1 (DE)
Inventor: HOSHIZAKI BLAINE
IPC: A43B5/04
Filed: 1994-11-29
Granted: 2001-05-17
Abstract: The skate boot has a one-piece plastic ankle and heel counter insert (4), positioned between the various layers which make up the skate boot. In sequence from outside to inside, the boot includes a conventional outer (2), the one-piece plastic insert, suitable cushioning (6, 8), and a lining (10). The insert has a heel counter portion which is generally U-shaped and which cups around the heel area from along the lateral side, across the heel, and along the medial side, and an integral ankle portion which extends upwardly from the heel area of the heel counter portion and which includes forwardly projecting wing portions which cup around the ankle area from over the area of the lateral malleolus, across the rear and over the area of the medial malleolus. Preferably, the plastic insert extends up most of the height of the back of the boot, and includes lateral and medial cuff portions which extend partially forward along the sides of the skater's upper ankle. The one-piece plastic insert provides improved performance and rigidity over conventional separate inserts, while avoiding the tendency of the ankle portion of the skate boot to slump down onto the heel portion with time.