Patent SG-11201407266P-A (SG)
Title: Polymorph compositions, methods of making, and uses thereof
Inventor: MACDONALD R LOCH
IPC: A61K31/4418
Filed: 2013-05-09
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/169979 A2 (51) International Patent Classification: A61K 9/16 (2006.01) A61K31/4418 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/040265 9 May 2013 (09.05.2013) English English (30) Priority Data: 61/644,523 13/800,480 9 May 2012 (09.05.2012) US 13 March 2013 (13.03.2013) US (72) Inventors; and (71) Applicants : MACDONALD, R., Loch [US/CA]; 20 Whitney Avenue, Toronto, ON M4W2A8 (CA). DAVIS, Cara, R. [—/US]; 106 Colonial Circle, Clanton, AL 35045 (US). BURTON, Kevin [US/US]; 616 Founders Park Drive, West, Hoover, AL 35226 (US). WINCHESTER, Gary [US/US]; 2028 Rising Fawn Drive, Warrior, AL 35180 (US). STELLA, Angela, R. [US/US]; 321 Callo­ way Lane, Pelham, AL 35124 (US). (74) Agent: LUBIT, Beverly, W.; Greenberg Traurig, LLP, 200 Park Avenue, Florham Park, NJ 07932 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) (54) Title: POLYMORPH COMPOSITIONS, METHODS OF MAKING, AND USES THEREOF FIG. 1 CJ o\ i> o\ o\ 72.3- 70- G5- 60- 55- 50- 45- %\ 40- 35- 30- 25- 20- 15- 10- G- o n o & (57) Abstract: The described invention provides a biodegradable, biocompatible delivery system of flowable sustained release mi- croparticulate composition of a substantially pure crystalline form of bioactive a agent such as, for example, nimodipine, a process of preparing therapeutic a form of substantially pure crystalline form a of the bioactive agent and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symp - toms of at least one delayed complication associated with brain injury.