baber/WOPTO huggingface dataset:
Patent CA-2597717-A1 (CA)
Title: Antibodies against cxcr4 and methods of use thereof
Inventor: XU CHEN
IPC: A61K39/395
Filed: 2006-02-15
Abstract: The invention provides human monoclonal antibodies, scFv antibodies, scFv-Fc fusions, a dAb (domain antibodies), Fab, Fab' and F(ab')2 fragments, single chain antibodies and/or minibodies that specifically bind to CXCR4. Also provided are methods of treating and/or preventing a CXCR4 disease or disorder such as cancer and X4-tropic HIV-I infection as well as uses of such antibodies and antibody fragments in the manufacture of a medicament for the treatment or prevention of a CXCR4 disorder. The invention also provides methods of preventing diseases or disorders associated with CXCR4 function or expression. The invention further provides for the use of the antibodies (or fragments thereof) of the invention in the manufacture of a medicament for the prevention of diseases or disorders associated with CXCR4 expression. Also provided are methods of treating or preventing cancer metastasis in a patient suffering from a cancer involving tumor cells that express CXCR4. The invention also encompasses the use of such antibodies and antibody fragments in the manufacture of a medicament for the treatment or prevention of cancer metastasis. The invention also includes methods of treating or preventing cancer metastasis in a patient suffering from a hypoxic tumor, such as any solid tumor characterized by HIF- dependent CXCR4 activation. The antibodies and fragments disclosed herein can be used in the manufacture of a medicament for the prevention of cancer metastasis in a patient suffering from a hypoxic tumor. The invention additionally provides methods of mobilizing CD34+ stem cells from the bone marrow as wells methods of blocking chemotaxis of CXCR4-expressing cells in response to SDF-1. Also provided are methods of treating or preventing graft-versus-host disease as well as the use of the antibodies and fragments thereof in the manufacture of a medicament for the prevention or treatment of GVHD. Finally, the invention also provides methods of inhibiting the formation of new tumor blood vessels and/or inhibiting tumor cell angiogenesis.
Patent CA-2601169-A1 (CA)
Inventor: WASON ANDREW
IPC: H04M3/00
Filed: 2006-03-16
Abstract: A third party call control (3PCC) application program interface (API) provides the capability for users to use a web browser or other Internet capable software to place a call. A third party call control application program interface comprises a first uniform resource locator (104) operable over the Internet to effect a call between a first telephonic device (118) and a second telephonic device (122). The first uniform resource locator includes identification of the first telephonic device (118) and identification of the second telephonic device (122).
Patent CA-2603989-A1 (CA)
Inventor: HAWRANEK JERZY
IPC: F28D7/16
Filed: 2006-04-11
Abstract: The present invention offers an improved axial heat exchanger for exchanging heat between a gas medium and a fluid or liquid medium. The axial heat exchanger comprises a longitudinal and substantially axially extended outer channel that is adapted to enclose a flow of a first gas medium. The heat exchanger also comprises a plurality of substantially parallel inner channels that are adapted to enclose a flow of a second liquid medium. The inner channels are arranged inside the outer channel so as to extend substantially axially along the inside of said outer channel for enabling a transfer of heat between said first gas medium and said second liquid medium. The heat transfer is improved to some extent as the number of inner channels increases and it is further improved in that at least one of the inner channels is joined with at least one elongated sheet. The sheet is arranged to extend substantially axially along the inner channel so as to substantially coincide . with the direction of flow of the first gas medium through the outer channel.
Patent CA-2604892-A1 (CA)
Inventor: ANGOLD RUSSDON
IPC: A61F2/74
Filed: 2006-04-13
Abstract: The lower extremity exoskeleton comprises two leg supports connectable to person's lower limbs and configured to rest on the ground during their stance phase. Each leg support comprises a thigh link and a shank link; a knee joint configured to allow flexion and extension between the shank link and the thigh link. The lower extremity exoskeleton further comprises an exoskeleton trunk connectable to the person's upper body. The exoskeleton trunk is connectable to the thigh links of the leg supports allowing for the flexion and extension between the leg supports and the exoskeleton trunk. Two torque generators are coupled to each of the knee joints. A power unit, capable of providing power, is coupled to the torque generators. In operation when a leg support is in a stance phase and climbing a slope or stairs, the power unit injects power into the respective torque generator thereby extending the respective knee angle.  When a leg support is in stance phase and not climbing a slope or stairs, the power unit does not inject any power to the respective torque generator, but without dissipating any stored power in said power unit, it forces the torque generator to resist flexion of the respective knee joint. When a leg support is in a swing phase, the power unit does not inject any power to the respective torque generator, but without dissipating any stored power in said power unit, it forces the torque generator to minimize its resistance to knee flexion and extension.
Patent CA-2605086-A1 (CA)
Inventor: CHIVERS ROBIN
IPC: A61B8/14
Filed: 2006-04-13
Abstract: A solid coupling material for conducting ultrasound from an ultrasound source to a surface, wherein the material maximises contact with the surface and the ultrasound source such that there are minimal or no air gaps in the interface between the surface and the material and in the interface between the ultrasound source and the material.
Patent CA-2605698-A1 (CA)
Title: Cover device for covering floors
Inventor: NEUHOFER FRANZ JUN
IPC: E04F19/06
Filed: 2006-04-20
Abstract: The invention relates to a covering device for covering floors, which comprises a cover profile (1) which is provided with a foot area (2) which is used to secure the cover profile (1) to a maintaining element (5) and a cover flange (4) which protrudes on both sides from said foot area (2), and a compensation profile (7) which can be used when desired. Said compensation profile can be connected in a positive fit to the cover flange (4) by means of a groove-spring connection. In order to use the traditional cover profiles (1), the compensation profile (7) forms a receiving groove (9) for one of the free longitudinal edges (8) of the cover flange (4) for the groove-spring connection.
Patent CA-2605870-A1 (CA)
Title: Blow molded universal lid
Inventor: TAYLOR CRAIG V
IPC: B65D51/04
Filed: 2006-05-02
Abstract: A lid for industrial or commercial large size solid waste containers has a ribbed single layer central portion and a peripheral edge having a hollow double wall boxed configuration. The lids have substantial symmetry so that the lids may be stacked and nested with alternate lids oriented in opposite front-to-back directions.
Patent CA-2606035-A1 (CA)
Inventor: KOWALCHUK DAN
IPC: B65G47/84
Filed: 2007-10-03
Abstract: A gate reader assembly for positioning and identifying articles carried by conveyor systems. The gate reader assembly including a main housing for attachment to said conveyor adjacent a conveyor line of the conveyor; a sprocket rotatably mounted on said housing and having a plurality of gullets formed thereon, each gullet configured for receiving one of said articles. In addition, said sprocket is configured to rotate about an axis normal to said conveyor line via a horizontal force from said articles such that said rotating sprocket is configured to receive and move said articles along said conveyor line. The gate reader assembly additionally includes a detent mechanism disposed on the housing and slidably coupled to the sprocket for releasably restraining said sprocket from rotation thereby inhibiting said article against further movement along said conveyor line. The gate reader assembly further includes a reader subassembly for mounting on said housing and for identifyi ng said articles when restrained by said detent mechanism.
Patent CA-2606649-A1 (CA)
Inventor: MAKELA MIKKO
IPC: H04L67/75
Filed: 2006-04-19
Abstract: A system and method for handling absolute positioning of content in an optimized layout on a display of an electronic device. Content in an original layout is provided, with the content including a primary element. A background element is identified, and a model of the content is calculated, the calculation includes the determination of the position of the primary element relative to the position of the background element. The primary element is positioned in the optimized layout in the same position relative to the background element as in the original layout.
Patent CA-2606887-A1 (CA)
Title: Pharmaceutical composition
Inventor: REMMAL ADNANE
IPC: A61K31/045
Filed: 2006-05-15
Abstract: The invention relates to a pharmaceutical composition comprising at least one first active therapeutic substance selected among carveol, thymol, eugenol, borneol, carvacrol, alpha-ionone, beta-ionone, as well as isomers, derivatives and mixtures thereof, and comprising at least one second active therapeutic substance that is an antiparasitic agent, in particular, an antimalarial agent . The invention is for use in the field of pharmaceutics.
Patent CA-2607182-A1 (CA)
Title: Therapeutic micro-vibration device
Inventor: SPAWR WALTER J
IPC: A61H1/00
Filed: 2005-11-10
Abstract: A therapeutic micro-vibration massaging device that also generates both a dynamic induction magnetic force field and an electromagnetic photonic optical light beam field, accompanied by audible acoustic sound, that penetrates the human body, induces an increase in cellular energy and thereby promotes a curative healing effect that reduces or eliminates pain.
Patent CA-2608283-A1 (CA)
Inventor: GILIYAR CHANDRASHEKAR
IPC: A61K47/22
Filed: 2006-05-04
Abstract: Cette invention concerne des compositions pharmaceutiques à libération synchronisée de l'agent solubilisant ainsi que diverses méthodes connexes. Plus précisément, la solubilité aqueuse d'un médicament est accentuée par la libération synchronsisée d'un agent solubilisant.
Patent CA-2609151-A1 (CA)
Inventor: WEN HUAFENG
IPC: A61C3/00
Filed: 2006-03-03
Abstract: Dental appliances for producing corrective movement in a subject's teeth include dental aligners which may be worn on a subject's teeth, gingiva or other region of the oral cavity. Described herein are dental appliances that include features that enhance the performance and comfort of the appliance, including features for preventing damage or wear on the appliance. Described herein are fluid-permeable aligners, wrinkled aligners, modular aligners, aligners of varying thickness, aligners of varying stiffness, snap-on aligners, textured aligners, aligners having multiple layers, and lateral correction aligners. Methods of making and using such aligners are also described.
Patent CA-2609734-A1 (CA)
Title: Method, system and wireless router apparatus supporting multiple subnets for layer 3 roaming in wireless local area networks (wlans)
Inventor: BAJIC ZELJKO
IPC: H04L29/06
Filed: 2006-05-26
Abstract: A wireless router is provided which is configured to support a first subnet and a second subnet. The wireless router comprises a plurality of virtual wireless switches. Each virtual wireless switch comprises a plurality of access ports. The first subnet comprises a group of the access ports belonging to the first virtual wireless switch, and the second subnet comprises a second group of the access ports belonging to the second virtual wireless switch. The wireless router is configured to support layer 3 mobility when a client, having a client IP address from within the first subnet, roams from the first subnet to the second subnet, from the first to the second virtual wireless switch. The wireless router stores registration information associated with the client to allow a client to roam between the first subnet and the second subnet while keeping the client IP address. The wireless router uses the registration information to send packets to the client when the client has roamed to the second subnet.
Patent CA-2610491-A1 (CA)
Title: Bicyclic derivatives for the treatment of abnormal cell growth
Inventor: PRAKASH CHANDRA AGGARWAL
IPC: A61P35/00
Filed: 2006-05-22
Abstract: The invention relates to substantially pure compounds of the formula (1): and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R5, and X are as defined herein, and wherein the compound of formula (1) optionally further comprises a hydroxy substituent, an O-glucuronic acid, or an N->O (N-oxide) moiety. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders that contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).
Patent CA-2610828-A1 (CA)
Inventor: SHAO YUEFEI
IPC: C07D487/04
Filed: 2006-06-12
Abstract: Disclosed are compounds of the formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein Q, T, U, Y, Z, ring A and R, R1, R2, R3, R4, R5, R6, R6, R7 and R7' are as defined in the specification; pharmaceutical compositions comprising the compounds of formula I and the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases.
Patent CA-2610889-A1 (CA)
Title: Active fraction of a polar solvent extract from the latex of euphorbiaceae plants
Inventor: CALIXTO JOAO B
IPC: A61K36/47
Filed: 2005-06-28
Abstract: The present invention generally refers to an active fraction of an extract of the latex of plants from the family Euphorbiaceae in a polar solvent, as well as of one or more compounds contained therein, as well as the use of said fraction and/or said compounds, particularly in the treatment of cancer. The invention also refers to compositions comprising said active fraction and/or said compounds, as well as their use for the treatment of diseases concerning cell proliferation/angiogenesis, particularly cancer.
Patent CA-2613751-A1 (CA)
Inventor: BRUDEVOLD FINN
IPC: A47J31/40
Filed: 2006-06-26
Abstract: A method and apparatus for Controlling a pump adapted to cause liquid to flow from a first location to a second location. The pump may be operated in a calibration period, and based on Performance characteristics for the pump, an Operation index may be assigned to the pump. The Operation index may be used to control subsequent Operation of the pump. For example, the Operation index may be used to identify an Operation time for the pump to deliver a predetermined volume of liquid. Performance characteristics used to determine the Operation index may include a voltage supplied to the pump and/or a volume flow rate of the pump.
Patent CA-2614102-A1 (CA)
Inventor: CHIBBER RAKESH
IPC: A23L33/00
Filed: 2006-07-06
Abstract: A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GIcNAc-T is provided, comprising administration of a therapeutically effective amount of an inhibitor of core 2 GIcNAc-T of formula (I) to a patient in need thereof wherein: R1 is H, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6- alkoxy or C1-6 -alkoxy- C1-6-alkyl; R2 is H, -OH or C1-6 alkoxy; S1 and S2 are independently selected saccharide moieties;  and Z is a steroid moiety; or a pharmaceutically acceptable salt, ether or ester thereof.
Patent CA-2615062-A1 (CA)
Inventor: HUANG YAN C
IPC: D21H19/00
Filed: 2006-07-11
Abstract: The invention relates to the papermaking art and, in particular, to the manufacture of paper or paperboard substrates, paper-containing articles such as multilayered paper or paperboard or corrugated-based packaging having a functional layer, as well as methods of making and using the same.
Patent CA-2615731-A1 (CA)
Title: Formulations that inhibit protein aggregation
Inventor: MATSUMURA MASAZUMI
IPC: A61K47/02
Filed: 2006-07-31
Abstract: Disclosed is a stable pharmaceutically acceptable formulation containing a pharmaceutically acceptable amount of a protein. Also disclosed are methods for preparing such formulations and methods for inhibiting protein aggregate formation induced by physical stresses associated with processing, manufacture, shipping, and storing protein formulations, particularly freeze/thaw stress.
Patent CA-2618132-A1 (CA)
Title: Led strobe for hazard protection systems
Inventor: SHUSTER JAMES
IPC: G08B5/38
Filed: 2006-07-10
Abstract: A light-emitting diode ("LED") based strobe may be used in automated system to provide a visual alert to occupants and/or building personnel if an emergency condition exists. A LED based strobe provides an even distribution of light having a sharp, bright pulse of light desired for emergency evacuation using lower power consumption.
Patent CA-2620428-A1 (CA)
Inventor: CHAVDA KAVITA
IPC: H04L12/26
Filed: 2006-09-04
Abstract: A solution for evaluating a performance of a network-based application is provided. A transaction performed by the application is decomposed into multiple components. One or more resources for each component are identified and performance data for each identified resource is obtained while the application processes the transaction. Based on the performance data, the performance of the application is evaluated. In this manner, the performance of the application can be comprehensively evaluated.
Patent CA-2621225-A1 (CA)
Title: Laser marking system for gemstones and method of authenticating marking
Inventor: SHACHRAI AVIGDOR
IPC: B42D25/435
Filed: 1996-11-14
Abstract: A laser microinscribing system includes a Q-switched Nd:YLF laser (1) with a harmonic converter producing an output of about 530 nm, an optical system including a focusing lens, a gemstone mounting holder (144) that is displaceable along three axes for moving a workpiece (11) such as a gemstone with respect to the optical system so that laser energy is presented to desired positions, an imaging system for viewing the gemstone from a plurality of viewpoints including a top CCD (28) and a side CCD (32), a processor controlling the position of the holder (144) based on marking instructions and a predetermined program, and a storage system (156) for storing information relating to images of a plurality of workpieces. A rigid frame supports the laser (1), the optical system and the holder (144) to increase immunity to vibrational misalignments. A secure certificate of authenticity of a marked workpiece (11) is preferably provided having an image of the marking as well as the outline of a girdle of the gemstone.
Patent CA-2621279-A1 (CA)
Inventor: BROWN TRACEY
IPC: A61K31/728
Filed: 2006-09-04
Abstract: The present invention relates generally to treatment and prophylactic protocols for cellular diseases or disorders, such as diseases and disorders associated with abnormal cellular proliferation. More particularly, the present invention provides compositions comprising therapeutic antibodies and hyaluronan and their use in the treatment or prophylaxis of cellular diseases and disorders.
Patent CA-2625343-A1 (CA)
Inventor: MOCHIZUKI KATSUHIKO
IPC: D01F8/14
Filed: 2006-10-18
Abstract: Disclosed are: a crimped yarn which comprises a synthetic fiber comprising an aliphatic polyester resin (A) and a thermoplastic polyamide resin (B) and in which the ratio of the exposed surface area of the aliphatic polyester resin (A) to the surface area of the fiber is 5% or less, wherein a multifilament composed of a plurality of the synthetic fibers is crimpled; a fiber structure comprising the crimped yarn as at least a part of the fiber structure. More specifically, disclosed are: a crimped yarn which comprises a polymer alloy synthetic fiber comprising an aliphatic polyester resin (A) and a thermoplastic polyamide resin (B); a crimped yarn which comprises a core-sheath-type composite fiber, wherein the core component comprises an aliphatic polyester resin (A) or a polymer alloy composed of the aliphatic polyester resin (A) and a thermoplastic polyamide resin (B) and the sheath component comprises the thermoplastic polyamide resin (B); and a fiber structure comprising the crimped yarn as at least a part of the fiber structure.
Patent CA-2625434-A1 (CA)
Title: Mobile wireless communications device including a ground patch providing specific absorption rate (sar) reduction and related methods
Inventor: QI YIHONG
IPC: H01Q1/22
Filed: 2008-04-09
Abstract: A mobile wireless communications device may include a portable housing, a dielectric substrate carried by the portable housing having a front side facing toward a user and a back side opposite the front side, and a ground plane carried by the dielectric substrate. The device may further include at least one circuit carried by the dielectric substrate, and an antenna carried by the dielectric substrate adjacent an end thereof and electrically connected to the at least one circuit. A ground patch may be adjacent the front side of the dielectric substrate that is electrically connected to the ground plane and spaced apart from and at least partially overlapping the antenna.
Patent CA-2628230-A1 (CA)
Inventor: OSHIGE WAKAKO
IPC: G03G15/08
Filed: 2007-09-13
Abstract: A black developer is conveyed in a first conveyance chamber in a rotation axis direction while agitating with rotation of a first screw member. A black-toner-concentration detecting sensor detects a toner concentration of the black developer by having contact with the black developer conveyed inside the first conveyance chamber. An average of peak amounts of a pressing force on the black developer, which is conveyed inside the first conveyance chamber by the first screw member, with respect to the black toner-concentration detecting sensor is set within a range of 9.8 15 [N/m2] to 9.8 100 [N/m2].
Patent CA-2634321-A1 (CA)
Inventor: FOO ONN FAH
IPC: H05B41/282
Filed: 2008-06-06
Abstract: A toroid-free ballast comprising a filter and rectifier circuit (10) coupled with an AC power, a switch and resonant circuit (20) coupled with the filter and rectifier circuit (10), characterized in that, the switch and rectifier circuit (20) comprises a half bridge oscillating circuit composed of two transistors. The present invention has the benefits of being toroid-free, as well as being relatively compact in configuration, low in cost and favourable for the miniaturization of the electronic ballast.
Patent CA-2635898-A1 (CA)
Inventor: SULLIVAN GARY J
IPC: H04N7/24
Filed: 2007-01-08
Abstract: Techniques and tools for high accuracy position calculation for picture resizing in applications such as spatially-scalable video coding and decoding are described. In one aspect, resampling of a video picture is performed according to a resampling scale factor. The resampling comprises computation of a sample value at a position i, j in a resampled array. The computation includes computing a derived horizontal or vertical sub-sample position x or y in a manner that involves approximating a value in part by multiplying a 2n value byan inverse (approximate or exact) of the upsampling scale factor. The approximating can be a rounding or some other kind of approximating, such as a ceiling or floor function that approximates to a nearby integer. The sample value is interpolated using a filter.