baber/WOPTO huggingface dataset:
Patent NZ-723313-A (NZ)
Title: Benzimidazole derivatives and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Inventor: BLANC JAVIER
IPC: C07D405/12
Filed: 2015-01-19
Abstract: The present invention discloses compounds according to Formula (I) wherein Cy, R1, L1 R3, R4, R5, La, and Ra are as defined herein. Novel benzimidazoles according to Formula (I), able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic diseases, inflammatory diseases, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or hypersecretion of interferons.
Patent NZ-729046-A (NZ)
Title: Car-t lymphocytes engineered to home to lymph node b cell zone, skin, or gastrointestinal tract
Inventor: LIANG BITAO
IPC: C12N5/0783
Filed: 2015-08-11
Abstract: In one embodiment, provided herein are cells, e.g., T cells expressing receptors that that cause a cell expressing the receptors to home to specific anatomical regions, e.g., the B cell zone of lymph nodes, the gastrointestinal tract, or the skin. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.
Patent NZ-737610-A (NZ)
Title: Anthelmintic depsipeptide compounds
Inventor: LEE HYOUNG
IPC: C07K11/02
Filed: 2016-05-20
Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
Patent NZ-742788-A (NZ)
Title: Night-light and alert system
Inventor: Brar Dev
IPC: G08B5/36
Filed: 2016-10-20
Abstract: Among other things, a system for lighting a light for an individual rising from a bed is provided. In particular embodiments, the system can include a mat and a light unit wirelessly connected, so that when an individual steps on the mat as he or she rises from the bed a signal is sent to the light unit, activating the light. A weight sensor in the mat can measure the weight placed on the mat, so that unintentional lighting can be avoided and so that weight information can be recorded. Embodiments can also include a signal transmitter to send weight and activation information to a remote receiver.
Patent NZ-745069-A (NZ)
Title: Pyrrolobenzodiazepines and conjugates thereof
Inventor: HOWARD PHILIP WILSON
IPC: C07D519/00
Filed: 2013-10-11
Abstract: The present invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepines having a labile C2 protecting group, in the form of a linker to a cell binding agent such as an antibody. Antibody therapy has been established for the targeted treatment of patients with cancer, immunological and angiogenic disorders. The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer, targets delivery of the drug moiety to tumors, and intracellular accumulation therein, whereas systemic administration of these unconjugated drug agents may result in unacceptable levels of toxicity to normal cells. Provided are PBD dimers with linking groups for the formation of PBD conjugates with cell binding agents, and in particular PBD antibody conjugates. In one aspect, the present invention provides a compound which is A, and salts and solvates thereof. It also provides a conjugate of formula ConjA where CBA represents an antibody or an active fragment thereof. Also provided are pharmaceutical compositions comprising a drug conjugate of the invention, use of the conjugate in the treatment of proliferative diseases and a method for preparing a conjugate of the invention.
Patent NZ-754381-A (NZ)
Title: A foam-based interfacing structure method and apparatus
Inventor: VELISS LEE JAMES
IPC: A62B9/04
Filed: 2009-09-03
Abstract: A respiratory mask to provide a supply of pressurized air to the entrance of the airways of a patient for treatment of sleep disordered breathing including a frame, and an interfacing structure comprising a connection portion (3234) and a cushioning component (3232). The connection portion is of reduced hardness or increased flexibility compared to the frame. The cushioning component is at least partially constructed from a foam material and is configured to directly engage and form a seal with a region of the patient’s face in the vicinity of an entrance to the patient’s airways. An interior of the interfacing structure at least partially forms a cavity to receive at least a portion of the patient’s nose in use. A connection portion attachment surface (3500) of the connection portion is joined to a cushioning component attachment surface of the cushioning component. At least one of the following parameters of the interfacing structure varies around a perimeter of the interfacing structure and at least contributes to a roll-in effect of the cushioning component: 1) an amount of offset between an inner edge of the connection portion attachment surface and an inner edge of the cushioning component attachment surface; 2) a cross-sectional profile of the connection portion; 3) an offset of an apex (3600) of a cross-sectional profile of the cushioning component; and 4) an angle of the connection portion attachment surface in a radial direction of the interfacing structure.
Patent NZ-769423-A (NZ)
Title: System and method for return end-to-end beamforming
Inventor: MILLER MARK
IPC: H04B7/204
Filed: 2016-04-08
Abstract: A method for end-to-end beamforming using an end-to-end relay comprises receiving a respective return uplink signal at each of a plurality of transponders of the end-to-end relay. A plurality of return downlink signals are transmitted by the plurality of transponders, each return downlink signal corresponding to a respective one of the return uplink signals. A corresponding superposition of the plurality of return downlink signals are received at each of a plurality of access nodes, to form a composite return signal. A return user beam is formed by applying return beam weights to the plurality of composite return signals, each of the return beam weights computed for one of a plurality of end-to-end return multipath channels that couples a reference location within the user coverage area with the plurality of access nodes, each channel having multipath generated by paths through the plurality of transponders, wherein applying the return beam weights comprises applying, to each composite return signal, the return beam weight associated with the access node that received that composite return signal.
Patent PT-100072-A (PT)
Inventor: MATTHEWS IAN RICHARD
IPC: C07C251/60
Filed: 1992-01-30
Abstract: Fungicidal compounds having the formula (I):    <IMAGE>  (I)  and stereoisomers thereof, wherein A is hydrogen, halo, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, phenoxy, nitro or cyano; R1 and R2, which may be the same or different, are hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclylalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl, optionally substituted aryloxyalkyl, optionally substituted heterocyclyloxyalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted aryloxy, optionally substituted heterocyclyloxy, nitro halo cyano, -NR3R4, -CO2R3, -CONR3R4, -COR3, -S(O)nR3 wherein is 0, 1 or 2, (CH2)mPO(OR3)2 wherein m is 0 or 1, or R1 and R2 join to form a carbocyclic or heterocyclic ring system; R3 and R4, which are the same or different, are hydrogen, optionally substituted alkyl, optionally substituted aralkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl or optionally substituted heteroaryl, or R3 and R4 join to form an optionally substituted heterocyclic ring; and R5 and R6 are independently hydrogen or C1-4 alkyl.
Patent PT-103680-A (PT)
Title: Sistema de indentificação automática de matrículas de veículos a partir de imagens vídeo
Inventor: GIRAO PEDRO SILVA
IPC: G06K9/20
Filed: 2007-03-09
Abstract: ESTE INVENTO, DESENVOLVIDO NA ÁREA DA ENGENHARIA ELECTROTÉCNICA, CONSISTE NA IDENTIFICAÇÃO AUTOMÁTICA DE MATRÍCULAS DE VEÍCULOS A PARTIR DE IMAGENS RECOLHIDAS POR UMA CÂMARA DE VIDEO. A SOLUÇÃO PARA A IDENTIFICAÇÃO AUTOMÁTICA DE MATRÍCULAS DE VEÍCULOS, QUE INCLUI A RECOLHA DE IMAGENS VÍDEO PASSA PELOS SEGUINTES PROCEDIMENTOS:
Patent RU-94009845-A (RU)
Inventor: KHELLER MART
IPC: B60T15/34
Filed: 1994-03-22
Abstract: FIELD: railway transport. SUBSTANCE: purpose of invention is provision of compatibility of operating member with two pressure steps and air distributor with three pressure steps and provision of second operating duty at which member with two pressure steps does not operate, and air distributor with three pressure steps meets requirements of International Railway Association. Problem is solved by installing additional member with valves and compressed air directing connections. EFFECT: enhanced reliability of braking. 10 cl, 5 dwg
Patent RU-94010381-A (RU)
Inventor: GUNAR T A
IPC: A01B79/02
Filed: 1994-03-24
Abstract: FIELD: recultivation of ash dumping grounds of heat-and-electric and hydroelectric power stations. SUBSTANCE: method involves development of contaminated lands in two stages: at the first stage, layer of fertile soil is applied onto leveled disturbed land, with layer being composed of sand, clay, peat, sand sublayers; mellowing layers, leveling and applying fertilizer; at the second stage, growing of auxiliary agricultural plant, such as topinambour, is carried out. This plant has roots and tubers facilitating formation of humus layer in soil. Tubers of the first year yield are left in soil and the layer obtained is deepened from year to year till thickness of layer reaches the value required to grow main agricultural crops, such as fodder or cereal crops. EFFECT: reduced cost by usage of common agricultural tools and machines, simplified method, quick repay of expenses, effective reprocessing of green mass and tubers of topinambour, improved quality of lands and ecology.
Patent RU-94010422-A (RU)
Inventor: NEJMAN A JA
IPC: H01S3/16
Filed: 1994-03-27
Abstract: FIELD: quantum electronics; solid-state rods of lasers operating both in continuous and pulsed modes. SUBSTANCE: according to invention, monocrystalline laser rod is made of high-temperature composite oxide material that has metal ions in surface layer and is characterized in that metal ions are those of indium or bismuth. Its manufacturing process involves mechanical and thermochemical treatment of rod in metal oxide powder; after mechanical treatment and before thermochemical treatment in metal oxide it is subjected to additional thermochemical treatment in two stages; during first stage, laser rod is dipped in powder mixture of indium molybdate with aluminium oxide in the following proportion, mass percent: In(MoO)-30-90; AlO- 10-70, followed by its heating to 900-1200 C; during second stage, rod is immersed in saturated alkali solution and boiled for 15-25 min, then subjected to thermochemical treatment in metal oxide powder where indium or bismuth oxide is used at temperature of 700-800 C for bismuth oxide and 1400-1450 C for indium oxide. EFFECT: improved stability to ultraviolet radiation of pump lamp and improved efficiency. 3 cl, 3 dwg
Patent RU-94015787-A (RU)
Inventor: VOROB EVA E V
IPC: C12G3/06
Filed: 1994-04-26
Abstract: FIELD: alcoholic beverage industry. SUBSTANCE: vodka comprises the following ingredients for kg/1000 dal: sugar, 28-32; for l/1000 dal: aqueous-alcohol oat infusion, 3.0-3.6; aqueous-alcohol liquid, the balance. EFFECT: higher tastiness.
Patent RU-94025344-A (RU)
Inventor: MAJER A A
IPC: G02F1/35
Filed: 1994-07-05
Abstract: FIELD: nonlinear integral and fibrous optics for development of optical transistors, modulators and logic elements. SUBSTANCE: method is based on phenomenon of self-transfer of unidirectional distributively coupled waves in cubic-nonlinear medium. EFFECT: provision for amplification of signal and creation of favorable conditions for realization of optical transistor and device of its base. 14 cl, 1 dwg
Patent RU-94027259-A (RU)
Inventor: SVETLICHNYJ A M
IPC: A61L2/10
Filed: 1994-07-18
Abstract: FIELD: medicine, can be used for sterilization of medical instruments. SUBSTANCE: the device for sterilization of medical instruments uses: 1 - working chamber; 2 - ceramic heat insulation; 3 - infrared sources; 4 - ultraviolet sources; 5 - bath; 6 - instrument to be sterilized; 7 - temperature-sensitive element with appliance for protection against lateral radiation; 8 - amplifier; 9 - infrared sources operating conditions setter; 10 - selector switch; 11 - power source of infrared sources; 11 - ultraviolet sources operating conditions setter; 12 - power source of ultraviolet sources. EFFECT: reduced time and enhanced efficiency of sterilization.
Patent RU-94029279-A (RU)
Inventor: BUGROV N V
IPC: B01J3/08
Filed: 1994-08-03
Abstract: FIELD: superhard materials dynamic synthesis, graphite diamond phases synthesis in particular; method is used for achievement of high degree compression of materials without their following destruction. SUBSTANCE: aim is realized due to the fact, that required for realization of graphite-diamond phase transition pressure and temperature are produced during electrical explosion of metal foil applied on dielectric interlayer on outer surface of carbon-bearing sample, that has form of hollow inside cylinder. Cylindrical form of sample provides the most full running of reaction and maximum dimension of synthesis zone under condition, that wall thickness is at least by 4 times exceeds inner radius. Presence of inner cavity allows to avoid sample collapse and destruction as a result of effect of cumulation during convergence of shock waves to axis of symmetry. To avoid inner breaking-away the cavity is filled with damping viscous material, squeezed out through butt surfaces during compression. Thickening layer of plastic dielectric is applied on outer surface of sample over explosive foil. Thickness and density of plastic dielectric layer is taken so, that its mass is no less than mass of carbon-bearing sample. This allows to prevent beginning of premature unloading and provide required duration of keeping pressures and temperatures at given level. EFFECT: method allows to achieve high degree of materials compression without their following destruction.
Patent RU-94030125-A (RU)
Inventor: VDOVENKO I F
IPC: G09B15/00
Filed: 1994-08-10
Abstract: FIELD: devices for education. SUBSTANCE: device has tone oscillator, amplifier, which input is connected to tone oscillator, and which output is connected to loudspeaker. In addition device has rhythm oscillator and first decoder, which is connected to first commutator, which outputs are connected to input of tone oscillator through tone setting resistors. In addition device has time-setting resistors of additional rhythm, which are connected to first and second inputs of TEMPO switch and to first input of rhythm oscillator. Output of TEMPO switch is connected to second input of rhythm oscillator, which output is connected to counting input of first binary counter for rhythm setting. Second to sixth bits of first binary counter are connected to five lines of second commutator, which columns are connected to distributed input of first eight multiplexers having eight channels. Outputs of multiplexers are joined and connected to counting input of second binary counter and to first input of pulse generator. Pair of terminals of two time-setting capacitors of pulse generator is connected to "common" line, their another pair is connected to first and second inputs of STROKE switch respectively. Output of STROKE switch is connected to second input of pulse generator, which output is connected to prohibition input of primary decoder. Three control inputs of primary decoder are connected to inputs of three high bits of second binary counter, outputs of three lower bits of second binary counter are connected to control inputs of first eight, second eight and third eight multiplexers, respectively. Prohibition inputs of multiplexers are connected to outputs of first decoder. Joined outputs of second and third eight multiplexers are connected to power supply line. Distributed outputs of said multiplexers are connected to inputs of second decoder, which output is connected to control inputs of duplex gates. Said inputs are connected to power supply line and outputs are connected to tone oscillator through tone setting resistors. Output of tone oscillator is connected to first of frequency divider, which second inputs are connected to first two lines, third inputs are connected to ten to sixteenth lines, fourth inputs are connected to seventeenth to nineteenth lines of first commutator, fifth inputs are connected to lines of third commutator and output is connected to input of amplifier, which output is connected to input of loudspeaker, which output is connected to common line through clipping resistor. Terminals of two additional clipping resistors are connected in parallel to primary one. Outputs of clipping resistors are connected to inputs of VOLUME switch, which output is connected to common line. Device may be used for teaching notes in musical schools. EFFECT: increased number of tones with respect to their frequency and duration.
Patent RU-94042610-A (RU)
Inventor: SKRIPNIK JU A
IPC: G01N27/22
Filed: 1994-11-30
Abstract: FIELD: may be used to measure humidity of various materials and substances of organic and inorganic origin. SUBSTANCE: method includes operations of action of high-frequency alternating voltage on exemplary capacitor and capacitive humidity converter connected in series, determination of phase shift between high-frequency voltages across capacitive humidity converter and exemplary capacitor, measurement of ratio of amplitudes of high-frequency voltages across capacitive humidity converter and exemplary capacitor and frequency of high-frequency voltage and computation of humidity of examined material by formula. Device for humidity measurement has high-frequency generator connected to capacitive humidity converter and exemplary capacitor connected in series, digital frequency meter, balanced-to-unbalanced transformer, digital ratio meter, digital phasemeter, interface, microcomputer with control panel and digital indicator. Primary winding of balanced-to-unbalanced transformer is connected to output of high-frequency generator, its secondary winding is linked to capacitive humidity converter and exemplary capacitor whose midpoint is grounded. Inputs of digital phasemeter and digital ratio meter are couped to potential terminals of exemplary capacitor and capacitive humidity converter. Digital outputs of phasemeter and ratio meter are connected through interface to inputs of microcomputer coupled to output of digital indicator. Digital frequency meter is connected with input to high-frequency generator and with digital output through interface to input of microcomputer. Four address outputs of microcomputer are connected correspondingly to high-frequency generator, digital frequency meter, digital phasemeter and digital ratio meter. EFFECT: higher efficiency.
Patent RU-94046117-A (RU)
Inventor: SJUZN MEHRI KAAS
IPC: C07F9/6506
Filed: 1993-05-26
Abstract: FIELD: organic chemistry. SUBSTANCE: products: compounds of the formulas (I), (II)and (III). Invention relates to the new sulfur-containing phosphonate compounds and new thio-substituted compounds involving biphosphonates, phosphonoalkylphosphonates, phosphonocarboxylates and phosphonosulfonates, and their pharmaceutically acceptable salts and esters. Then, invention relates to the pharmaceutical compositions containing safety and effective amount of proposed compounds and pharmaceutically acceptable carriers. Then, invention relates to the methods of treatment and prophylaxis of pathological states exhibiting anomal calcium and phosphate metabolism in human and other mammalian involving treatment and prophylaxis of osteoporosis and arthritis. Method involves administration of safety and effective amount of compound or composition of this invention to human or other mammalian. New sulfur-containing compounds have the general formula (I)at condition that at least one of R, R, Ror Ris SRor RSR. Then, this invention relates to the treatment of arthritis in human or other mammalian that involves administration of safety and effective amount of thio-substituted compound of the formula (III)at condition that at least one of R, R, Ror Rmust be SRor RSR.. EFFECT: improved method of synthesis, enhanced effectiveness of treatment.
Patent RU-95101570-A (RU)
Inventor: BOBROV-EGOROV N N
IPC: A61K36/185
Filed: 1995-02-01
Abstract: FIELD: medicine. SUBSTANCE: balsamic bioactive composition has an aqueous extracts of plants - cudweed, milfoil, celandine, thyme, marjoram and Saint-John's-wort herb, mint leaves, pine buds, pot-marigold and matricary flowers, horse dock fruits and/or leaves, and licorice root; essential oils of the order: mint, coriander, anise, fir and camphor as aromatic component; ammonium hydroxide as preserving agent; glycerol, oleic acid as cosmetic agent; distilled water as extract. Aromatic component is used with tonic additions at amount 0.2% of base weight, not above. Composition can contain these components at different combinations and contents. Invention proposes method of agent preparing also. Composition is used in surgery, urology, dermatology, stomatology and other branches of medicine. EFFECT: enhanced effectiveness of composition. 3 cl
Patent RU-95101824-A (RU)
Inventor: VYSHENSKIJ M V
IPC: E21B43/00
Filed: 1995-02-07
Abstract: FIELD: oil deposit development, particular, methods of oil production from a group of marginal producer operating for overflow. SUBSTANCE: the offered method includes mechanical withdrawal of oil from pipe space and gas from drill string-borehole annulus of one of wells. Novelty consists in that this group of wells is combined into single airtight system and connected with drill string-borehole annulus of the well from which the indicated above withdrawal of oil and gas is effected. EFFECT: reduced expenditures for oil production due to 5-fold reduction of applicable equipment, 5-fold reduction of starting and adjustment operations and 2-3-fold reduction of the total metal content of equipment.
Patent RU-95101827-A (RU)
Inventor: MAJNRAD MEJER
IPC: F16H21/00
Filed: 1995-02-07
Abstract: FIELD: materials handling. SUBSTANCE: device has transportation cam which gets into flow of transported articles, catches an article and, pushing it from the rear, transfers to taking in transportation arrangement. To transfer each article cam should return in initial position out of the limits of article flow. According to invention device has hinged four-member mechanism with drive crank a, rocker b, driven crank c and fixed lever d. Transportation cam is mounted on rocker c in point of coupling C. Hinged four-member mechanism is made in form of crank-and-rocker gear which meets other requirements. EFFECT: enlarged operating capabilities. 12 cl, 4 dwg