baber/WOPTO huggingface dataset:
Patent SG-11201906807V-A (SG)
Title: Compositions and methods for promoting hair growth with mpc1 inhibitors
Inventor: LOWRY WILLIAM
IPC: A61K8/49
Filed: 2017-08-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) WIPO I PCT omit °nolo oui mom° oimIE (10) International Publication Number WO 2018/039612 Al (51) International Patent Classification: A61K 31/405 (2006.01) A61K 8/49 (2006.01) A61K 31/404 (2006.01) A61P 17/14 (2006.01) (21) International Application Number: PCT/US2017/048701 (22) International Filing Date: 25 August 2017 (25.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/380,205 26 August 2016 (26.08.2016) US 62/463,232 24 February 2017 (24.02.2017) US (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor, Oakland, CA 94607-5200 (US). (72) Inventors: LOWRY, William, E.; University Of Califor- nia Los Angeles, Department Of Molecular Cell And De- velopmental Biology, 621 Charles Young Drive, Los An- geles, CA 90095 (US). CHRISTOFK, Heather; Univer- sity Of California Los Angeles, Department of Biological Chemistry, 615 Charles Young Drive South, Los Angeles, CA 90095 (US). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) W O 20 18/0396 12 Al (74) Agent: HALSTEAD, David, P. et al.; Foley Hoag Llp, 155 Seaport Boulevard, Boston, MA 02210-2600 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: COMPOSITIONS AND METHODS FOR PROMOTING HAIR GROWTH WITH MPC1 INHIBITORS (57) : Provided herein are methods of accelerating, promoting, or restoring hair growth, comprising administering to a subject in need thereof an effective amount of a compound of formula (I). Also provided are compositions comprising the compound of formula (I).
Patent HU-187005-B (HU)
Inventor: ARATO EMILIA
IPC: F28F7/00
Filed: 1983-01-05
Abstract: A találmány tárgya hőhasznosító berendezés,
amely önhordó lemezszerkezetből vagy térhatároló
elemekkel ellátott keretszerkezetből, valamint kerresztáramú
hőátadó felületekből van kialakítva és
tömítőanyaggal, valamint rögzítőelemekkel van ellátva.
A találmány lényege abban van, hogy a hőátadó
felületeket önhordó kivitelű megközelítően tégla·,
test alakú hó'átadó blokkok felületei alkotják, amelyek
oldható kötéssel csatlakoznak a vázhoz.
A találmány előnyös kiviteli alakja szerint az önhordó
keresztáramú hőátadó blokkok és a váz közötti
méreteltéréseket egy a hőátadő blokkokat és rögzítőelemeket
is magábafoglaló kompenzációs elem veszi
fel. Kompenzációs elemnek a méreteltéiések felvétele
után szabadon maradó terében részben vagy egészben
tol deformálható tömítőanyag van elhelyezve. További
előnyös kiviteli alak szerinti a hőátadó blokkok és
a váz közötti rögzítő szerv villamos szigetelőt tartalmaz
vagy anyagában villamos szigetelő.
Patent HU-188410-B (HU)
Inventor: ROCHHAUSEN DIETER
IPC: F04B39/00
Filed: 1983-01-07
Abstract: Die Erfindung betrifft eine Einrichtung zur Geraeuschsenkung bei hermetischen Kaeltemittelverdichtern, die vorzugsweise in Haushaltkaeltegeraeten eingesetzt werden. Ziel und Aufgabe der Erfindung ist es, die Geraeuschkennwerte der hermetischen Kaeltemittelverdichter durch deren diesbezuegliche Optimierung im 500Hz- Terzband zu senken. Die Merkmale der Erfindung liegen darin, dass der hermetische Kaeltemittelverdichter innerhalb der Kapsel so gestaltet ist, dass Hohlraumresonanzen verhindert werden. Die Besonderheit der Erfindung liegt darin, dass die rotierenden und oszillierenden Teile einen Stroemungswiderstandsbeiwert c<0,5 haben. Die Anwendungsgebiete der Erfindung liegen im Bereich der hermetischen Kaeltemittelverdichter.
Patent AT-400070-B (AT)
Title: Water-tube boiler
Inventor: BERTSCH OTMAR DIPL ING
IPC: F23J15/02
Filed: 1991-03-01
Granted: 1995-09-25
Abstract: The water-tube boiler possesses a flue-gas duct 2 connected to the furnace space and a DeNOx system, arranged therein, in the form of a catalyst 10 and also an NH3-injection device 9 for reducing the NOx fractions in the flue gas. A portion of the flue-gas duct 2, which is located upstream of the catalyst 10, as seen in the direction of flow of the flue gas, is subdivided into two flue-gas chambers 14, 15 parallel to one another in terms of flow. A heat exchanger 4, 5 is provided in each of the two flue-gas chambers 14, 15 used for operating the boiler. The passage cross section of each flue-gas chamber 14, 15 is variable. The throttle flaps 6, 7 assigned to the flue-gas chambers 14, 15 for this purpose are controlled by the temperature of the heat-transfer medium. The heat exchangers 4, 5 provided in the two flue- gas chambers 14, 15 have surfaces of different size and/or the cross sections of the two flue-gas chambers 14, 15 are of different size. <IMAGE>
Patent HU-188766-B (HU)
Inventor: HEGYI FERENC
IPC: E21B43/00
Filed: 1982-01-22
Abstract: A találmány olyan eljárásra vonatkozik, melynek segítségével a folyadéköblítéssel működő fúrások öblítőfolyadék-veszteségeinek megelőzése, csökkentése, illetve megszüntetése érhető el. Alkalmas az eljárás a tárolóterek védelmének biztosítására is. Az eljárás lényege az, hogy a fúrólyukba olyan fúróiszapot, vagy kezelőfolyadékot juttatunk, mely legalább 100 mPas feletti dinamikus viszkozitással rendelkező természetes, vagy szintetikus polimergélt tartalmaz. A polimergélt az iszapveszteséges formáció résméreteinek megfelelően 1—100 mm szemcseméretűre aprítva alkalmazhatjuk. -1-
Patent HU-191773-B (HU)
Inventor: PERLENYI OTTO
IPC: G08B13/00
Filed: 1985-02-05
Abstract: Belsőterek védelmére szolgáló elektronikus riasztóberendezés
a nyílászárók belső oldalán elhelyezett modulált
aktív infravörös fénysorompókat és hamis fénysorompókat
tartalmaz érzékelőként, melyek ajtó esetében
késleltetőfokozaton (4) át, ablak esetében közvetlenül
a védett téren belül elhelyezett, védett téren
belüli és kívüli hangszóróval (Hl, H2) összekapcsolt
vészjelzőegységek (6, 13) működési idejét meghatározó
időzítőfokozatokra (5, 12) csatlakoznak. A késleltető
fokozat (4) kimenetére riasztást hatástalanító rejtett
szenzoros kapcsoló (7), míg a védett téren kívüli
hangszóró (H2) vészjelzőegységének (13) időzítőfokozatára
(12) védett téren belül elhelyezett rejtett
riasztókapcsoló (10) van rákötve. A külső hangszóró
(H2) melegpontjára szakadás illetve zárlat jelzőegység
(14) csatlakozik. Ennek kimenetei az időzítőfokozatokra
(5, 12) vannak vezetve. Az érzékelőegységek
(II-1V), a kapcsolófokozatok és a késleltetőfokozat
(4) kimenetére önzáró bistabil billenőkor (16-19,21,
42) tagjaiként kialakított állapotjelző világítódiódák
(LD1-LD6, LD9) vannak rákötve. A stabilizált hálózati
tápegységben a riasztóberendezés szünetmentes
tápellátást lehetővé tevő akkumulátortelep (30) van
elhelyezve.
Patent HU-186042-B (HU)
Title: Process for producing benzamide derivatives
Inventor: FLORVALL GOESTA L
IPC: C07D207/09
Filed: 1982-03-10
Abstract: Novel therapeutically active compounds of the formula   <IMAGE> I wherein R1 and R2 are the same or different and each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group or an acyl group, R3 is a lower alkyl group; an alkenyl group; or a benzyl group optionally substituted with fluorine, chlorine, bromine, trifluoromethyl, lower alkyl or lower alkoxy, A1 and A2 are the same or different and each represents a hydrogen atom, a lower alkyl group, an acyl group, an alkoxycarbonyl group or a dialkylcarbamyl group, provided that when A1 and A2 are the same lower alkyl group and R3 is ethyl, R1 or R2 or both are selected among cyano, lower alkyl and acyl; or a physiologically acceptable salt or optical isomers thereof, methods for their preparation, pharmaceutical preparations containing the compounds and methods for their therapeutical use.
Patent YU-49380-B (YU)
Inventor: DORDE KRSTIC
Filed: 1998-07-15
Abstract: Najlakši tavanični element, za izradu sitnorebrastih polumontažnih armiranobetonskih horizontalnih i kosih tavanica, naznačeno time, se sastoji iz troslojne kombi ploče (1), i na njoj sitnozrnim betonom (5) ugradjene dvostruke armirane rešetke (2), dodatne odgovarajuće armature (3), i tela punioca od samogasivog stiropora (4), što je izgradjen tako, da je na odgovarajućoj horizontalnoj podlozi, na kombi troslojnu ploču (1), dužine prema odgovarajućem rasponu, u osi elementa, ugradjena pomoću sitnozrnog betona (maltera) (5), dvostruka armaturna rešetka (2), dodatna odgovarajuća armatura (3), i tela ispune od samogasivog stiropora (4), dimenzija prema statičkoj visini, a zatim pod minimalnim pritiskom ostvarenim tegovima, ili na drugi način, odležava 21 dan radi očvršćavanja, a potom se na mestu ugradnje, postavljanjem najlakših tavaničnih elemenata, jedan pored drugog, na odgovarajućem rasponu, na poduprtim gredicama, formira ploha, koja ugradnjom odgovarajuće marke betona (6), po očvršćavanju formira Prijava sadrži još 1 zavisan patentni zahtev.
Patent YU-48689-B (YU)
Inventor: TOMISLAV TODOROVIC
Filed: 1992-07-16
Abstract: Dvostepena radijalna akciono-reakciona turbina kod koje je koncentrično oko sprovodnog aparata 2, a radijalno na glavnu osu turbine, postavljeno radno kolo 6 turbine za pogon kompresora koja poseduje lopatice 8 i kanale 9 i radno kolo 7 pogonske turbine koja poseduje lopatice 8' i kanale 9', naznačen time, što je na disku (3) izveden sprovodni aparat (26) sa protočnim kanalima (27) koji je ugradjen izmedju radnih kola (6, 7).
Patent AT-410218-B (AT)
IPC: C12N15/09
Filed: 1999-08-20
Granted: 2003-03-25
Abstract: A method for producing a pool of biological samples that is quality assured with respect to the load with microorganisms, using a nucleic acid amplification method, in which a screening pool is tested with a high sensitivity nucleic acid amplification method and can be divided into screening subpools, which are tested with a less sensitive nucleic acid amplification method, where individual samples can be picked out and eliminated, is described.
Patent CH-611766-B (CH)
Inventor: ITO TERUO
IPC: G04C13/11
Filed: 1975-06-24
Abstract: 1463223 Stepping motors DAINI SEIKOSHA KK 19 May 1975 [25 June 1974] 21286/75 Heading H2A In a stepping motor comprising a permanently magnetized rotor 5 and a wound stator having a pair of pole pieces 3, 4 with part-cylindrical pole faces 3a, 4a, a recess 12a or 12b is provided in at least one of the pole faces 3a, 4a, and a bush 24 is used to locate the pole pieces 3, 4 on a mounting plate 22 so that the pole faces 3a, 4a are coaxial with the rotor 5. In the motor shown, the bush 24 is fixed in an aperture 23 in the plate 22, and supports one of two rotor bearings 20, 21, and as a consequence of the recesses 12a, 12b the rotor 5 can only rotate in one direction if a pulse train such as in Fig. 6 (not shown), is delivered to a stator winding 1. The recesses need not be opposite one another, and may have various other shapes, e.g. as in Figs. 7A-7F (not shown). The motor may be used in electric watches (no details).
Patent DK-153332-B (DK)
Inventor: STRAW ALAN
IPC: C11D1/83
Filed: 1978-05-10
Abstract: A liquid hard surface cleaner is disclosed that is impalpable, self-opacifying, enjoys low temperature stability and has satisfactory viscosity and detergency, these being achieved by a particular combination of ingredients and proportions; namely, the composition comprising, by weight, a water-soluble, synthetic, anionic, sulphated or sulphonated detergent salt containing an alkyl radical of 8 to 22 carbon atoms in the molecule, a water-soluble alkylene oxylated nonionic detergent, a water-soluble detergent builder salt and the balance water, the weight ratio of anionic detergent to nonionic detergent being from 0:5 to 6:1 and the weight ratio of builder salt to total detergent being in the range of 1:5 to 5:1.
Patent DK-165452-B (DK)
Inventor: UMEZAWA HAMAO
IPC: C07H15/252
Filed: 1987-12-04
Abstract: The present invention relates to anthracycline derivatives of the general formula I <CHEM> where R represents the group -(CH2)mH in which m denotes 0 or an integer of 1 to 6, or the group -(CH2)nCOOH in which n denotes 0 or an integer of 1 to 10, and a process for their preparation. The compounds of the invention exhibit high antitumor activity and good water solubility and can, therefore, be used as medicaments.
Patent FI-64202-B (FI)
Inventor: KOSKI ERKKI
IPC: D21G9/00
Filed: 1981-10-27
Granted: 1983-06-30
Abstract: PCT No. PCT/FI82/00049 Sec. 371 Date May 26, 1983 Sec. 102(e) Date May 26, 1983 PCT Filed Oct. 25, 1982 PCT Pub. No. WO83/01636 PCT Pub. Date May 11, 1983.A size press, which comprises three coating rolls (11, 12, 13). These rolls (11, 12, 13) form two press nips (N1, N2) as pairs with each other, the paper web (W) to be treated being passed through the said press nips. Both sides of the web (W) are treated in the said nips (N1, N2). Out of the said coating rolls, regarding the position of altitude, the uppermost roll (12) has been arranged as the center roll of the size press, in connection with which center roll the two coating nips (N1, N2) are formed so that the first coating nip (N1) is placed at a short angular distance ( alpha 1) underneath the horizontal plane (H-H) placed through the axis of the said center roll (12). The second coating nip (N2) is formed by the third coating roll (13), which is placed substantially in the vertical plane (V-V) placed through the center point of the center roll (12) or at a small angle ( alpha 2) after the said plane. As preceding the first nip (N1), size-feed devices (24, 25) have been provided at the center-roll (12) side of the run of the web (W), which size-feed devices (24, 25) feed a first size pool (L1) or layer into the substantially vertical pit between the center roll (12) and the web (W). Preceding the second nip (N2), a second set of size-feed devices (26, 27) has been provided in the substantially horizontal pit formed by the center roll (12) and by the third coating roll (13), the said second size-feed devices (26, 27) forming the second size pool (L2) or layer at the opposite side of the web (W), as compared with the said first size pool (L1) or layer. The said devices are jointly operative so that, while the sizing is performed, the web (W) is supported by a roll face.
Patent FI-77775-B (FI)
Inventor: TRANBERG POUL
IPC: F16L37/28
Filed: 1982-11-23
Granted: 1989-01-31
Abstract: A self-sealing, sterile connector assembly for use in a surgical drainage system includes releasably cooperable plug and socket parts (3, 4), the plug part (3) incorporating a slidable sleeve valve (3d), and the socket (4) incorporating a normally closed disc valve (5). Both valves are actuated, i.e. opened and closed respectively, by the relative plugging and unplugging movement between the plung and socket parts. The plug and socket parts (3, 4), and the valves (3d, 5), are so configured that, during unplugging movement between the parts (3, 4), the valves (3d, 5) close in a manner which avoids the formation of any voids therebetween capable of accommodating sufficient liquid to form drips.
Patent FI-80374-B (FI)
Inventor: BERZ HANS-PETER
IPC: A47J31/057
Filed: 1984-05-11
Granted: 1990-02-28
Abstract: An electric coffee percolator is provided with a fresh water container located above a water heating chamber sized to receive and retain about 30-60% of the volumetric amount of fresh water required for a complete coffee infusion. The heating chamber is separated by a common wall from the water container and receives fresh water therefrom through a non-return value located in the common wall. A ventilating pipe in the water container is slidably amounted in the common wall to project a selected distance into the heating chamber so that the water level in the heating chamber can be adjusted. A check valve in the ventilating tube prevents expulsion of water from the heating chamber into the water container. The bottom wall of the heating chamber is provided with an electric heating element surrounding a well from which a riser pipe through which the hot water is expelled extends upwardly to a water outlet chamber having a cross-sectional area which increase in size from its inlet end to its outlet end. The end of the riser disposed in the well is shaped to release steam pressure prior to the expulsion of the last bit of water remaining in the heating chamber to prevent the remainder of the water from being expelled at an excessive speed.
Patent FI-87349-B (FI)
Inventor: WILHELM DIDIER
IPC: C07D233/32
Filed: 1988-03-31
Granted: 1992-09-15
Abstract: They have the formula:    <IMAGE>  (I)  where either R1 and R2 are identical and represent -CH2R where R=H or a C1 to C4 alkyl group or R1 and R2 together form the -CH2(CR4R4)n-CH2 group where n=0 or 1, R4 =H or -CH3, R3=H or -CH2R5 where R5=H or a C1 to C4 alkyl group. A and A1 are either identical and represent H or A and A1 together form an ethylene, trimethylene or -CH(OCH2R6)-CH(OCH2R6)- radical where R6=H or a C1 to C4 alkyl group or, when R3=H, a 1,2 dihydroxy-ethylene group. They are obtained by reacting a disubstituted ethanal    <IMAGE> (II)  with a urea ANH-CO-NHA, followed if required by etherification with an alcohol R5CH2OH.
Patent FI-82404-B (FI)
Title: Device for reception and lateral displacement of planks or equivalent
Inventor: VOUTILAINEN HANNU
IPC: B27B/
Filed: 1989-07-17
Granted: 1990-11-30
Abstract: A device for the reception and lateral displacement of planks 3 which are fed out from an edge saw 1, which device comprises a movable chain 6, which supports the planks and advances them in the direction of the saw, and pressure rollers 9, which press the planks against the chain. In order to halt the movement of the planks, the device is provided with raisable and lowerable members 10, which are arranged to lift the planks up out of the reach of the said chain. The device also comprises members 18 which remove the planks from the lifting members and feed them to a cross conveyor 16. <IMAGE>
Patent FI-94245-B (FI)
Inventor: NISHIMOTO SHIGERU
IPC: C07D281/10
Filed: 1990-04-23
Granted: 1995-04-28
Abstract: There is disclosed a process for preparing 1,5-benzothiazepine derivatives represented by the formula: <CHEM> wherein one of R<1> and R<2> is a lower alkyl group or halogen atom, and the other is hydrogen atom, R<3> is a lower alkyl group or a lower alkoxy group, which comprises subjecting a propionic acid compound represented by the formula (II): <CHEM> wherein R<1>, R<2> and R<3> have the same meanings as defined above,  to intramolecular ring closing reaction in the presence of a sulfonic acid compound represented by the formula (III):    R<5>SO3H   (III> wherein R<5> represents a lower alkyl group or a substituted or unsubstituted phenyl group.
Patent FI-105300-B (FI)
Inventor: HERTER EBERHARD
IPC: H02J13/00
Filed: 1991-09-25
Granted: 2000-07-14
Abstract: The invention relates to a circuit for receiving information carried by a two-wire power line and having a frequency which is orders of magnitude higher than the frequency of the low-frequency AC voltage on the power line. The AC voltage on the power line, which interferes with information transmission, is eliminated by coupling the evaluation circuit via a high-resistance resistor bridge into which either a compensation voltage of the same frequency but in antiphase is injected or which bridge is changed in its balance in a frequency-dependent manner by a capacitor. <IMAGE>
Patent FI-97310-B (FI)
Inventor: STRAESSLE MARCEL
IPC: E04B1/58
Filed: 1991-10-15
Granted: 1996-08-15
Abstract: PCT No. PCT/CH91/00039 Sec. 371 Date Sep. 23, 1991 Sec. 102(e) Date Sep. 23, 1991 PCT Filed Feb. 13, 1991 PCT Pub. No. WO91/12383 PCT Pub. Date Aug. 22, 1991.A connection element for a three-dimensional framework includes a bolt (6, 7, 8, 9) which by means of a sleeve insert (3) can be fastened rotatably to one end of a rod (11), as well as a sleeve (12) into the axial through-bore of which the bolt is partly inserted, to transmit, sliding axially, a rotary movement of the sleeve (12) to the bolt. The through-bore is only in the front part of the sleeve (12) so that it can transmit a rotary movement of the sleeve (12) to the bolt. At the rear part of the sleeve (12) the through-bore has a circumference which is larger than the circumference of the form-locking front part of the through-bore. The bolt is urged out of the sleeve (12) by a spring (13). The front end part (9) of the connection element can be fastened to a junction part (10) of the three-dimensional framework.
Patent FI-109171-B (FI)
Inventor: TAHON BERNARD
IPC: H05B7/14
Filed: 1993-06-17
Granted: 2002-05-31
Abstract: Coupling for the rigid and stationary end-connection of graphite or carbon electrodes whose ends contain a sleeve tube with an internal threading into which is screwed a double-threaded connector or nipple pierced with holes acting as reservoirs containing a solid and electrically conductive cement, characterised in that at least one of the said reservoirs is filled with a synthetic cement consisting of a thermosetting resin, which, in the presence of a catalyst, melts at a temperature greater than 60 DEG C in order to form a liquid phase with a viscosity below 2500 centipoises between 90 DEG C and 120 DEG C and to polymerise at a temperature greater than or equal to 120 DEG C. <IMAGE>
Patent FI-114285-B (FI)
Inventor: HEAFIELD JOANNE
IPC: A61K47/44
Filed: 1994-06-30
Granted: 2004-09-30
Abstract: In order to provide a sustained release pharmaceutical formulation containing morphine which is suitable for administration on a once daily basis, in a first aspect, an orally administrable sustained release dosage unit form contains morphine, or a pharmaceutically acceptable salt thereof, as active ingredient, which formulation gives a peak plasma level at 1.0 to 6 hours after administration. In a second aspect, the formulation contains an effective amount of morphine or a pharmaceutically acceptable salt thereof, characterised by a W50 for the M-6-G metabolite or for morphine of between 4 and 12 hours. In a third aspect, the pharmaceutical dosage unit form is obtainable by compressing multiparticulates comprising a pharmaceutically active substance in a matrix of hydrophobic fusible material having a melting point of from 35 to 150 DEG C, the dosage form optionally containing conventional tabletting excipients. In a further aspect of the invention, sustained release multiparticulates containing morphine or a pharmaceutically acceptable salt thereof are produced by mechanically working in a high-speed mixer a mixture of particulate morphine or a pharmaceutically acceptable salt thereof and a particulate, hydrophobic fusible carrier or diluent having a melting point from 35 to 150 DEG C and optionally a release control component comprising a water soluble fusible material or a particulate soluble or insoluble organic or inorganic material at a speed and energy input which allows the carrier or diluent to melt or soften whereby it agglomerates, and breaking down the agglomerates to give controlled release particles.