Patent AU-2012327167-B2 (AU)
Title: Use of growth hormone fragments
Inventor: KENLEY DAVID
IPC: A61K38/18
Filed: 2012-12-07
Granted: 2015-04-23
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/082667 A1 13 June 2013 (13.06.2013) W I P0 I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K38/18 (2006.01) A61P 19/04 (2006.01) kind of national protection available): AE, AG, AL, AM, A61P 19/02 (2006.01) A61P 21/06 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, ) .a BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, PCT/AU2012/001497 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 7 December 2012 (07.12.2012) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (25) Filing Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (26) Publication Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 2011905132 9 December 2011 (09.12.2011) AU (84) Designated States (unless otherwise indicated, for every 2011905133 9 December 2011 (09.12.2011) AU kind of regional protection available): ARIPO (BW, GH, 2012901398 10 April 2012 (10.04.2012) AU GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, 2012901400 10 April 2012 (10.04.2012) AU UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant: METABOLIC PHARMACEUTICALS PTY EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, LTD [AU/AU]; Unit 2, 320 Lorimer Street, Port Mel- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, bourne, Victoria 3207 (AU). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (72) Inventor: KENLEY, David; 21 Halstead Street, Caulfield ML, MR, NE, SN, TD, TG). North, Victoria 3161 (AU). Published: (74) Agent: GRIFFITH HACK; GPO Box 1285, Melbourne, - with international search report (Art. 21(3)) Victoria 3001 (AU). - with amended claims (Art. 19(1)) (54) Title: USE OF GROWTH HORMONE FRAGMENTS AOD TREATMENT ENHANCES CARTILAGE TISSUE FORMATION IN VITRO Collagen CONTROL 0 ugml 10 ug/ml 100 ug/ml *3 ksi, itro-fo d cartlge. m n tSD, p<0.05 Figure 3 (57) Abstract: The invention provides a method for treating a condition in which growth hormone administration is beneficial, for treating osteoarthritis, for increasing chondrocyte, proteoglycan or collagen production or quality or repair or promoting cartilage tis sue formation or repair, for promoting or improving muscle, ligament or tendon mass, repair, form or function, or for treating inflam matory, traumatic or genetic diseases of muscle or connective tissue, comprising administering to a subject an effective amount of a f4 peptide comprising a carboxyl-terminal sequence from a growth hormone and not the IGF-l domain of growth hormone. It also provides a method of treating a condition involving insufficient functional chondrocytes or insufficient functional cartilage tissue, the method comprising administering to a subject in need thereof a peptide comprising a carboxyl-terminal sequence from a growth hormone and not the domain of growth hormone responsible for IGF- 1 production.