baber/WOPTO huggingface dataset:
Patent IL-125759-A0 (IL)
Title: Sugar-modified gapped oligonucleotides
IPC: C07H21/00
Filed: 1997-02-07
Abstract: Oligonucleotides are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary nucleic acid strand, and subsequences of 2'-deoxy-erythro-pentofuranosyl nucleosides that activate RNase H. Such oligonucleotides are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to ooligonucleotide therapeutics.
Patent IL-130211-A0 (IL)
Title: Device for local administration of solid and semisolid formulations sustained-release formulations for parenteral administration and method of preparation
IPC: A61M25/00
Filed: 1997-12-02
Abstract: The use of a specific device is claimed for implantation or insertion of a solid or semi-solid formulation (F), containing an active ingredient (A), into an organism at a precise receptor site. The device includes a component which is inserted into the body of the patient, can store (F) and can position (F) the precise site where it is required. The injection or insertion of (F) can be controlled externally. The device is withdrawn after (A) has been so placed. Formulations for use in the device are also claimed, specifically containing at least 50% of (A) mixed with a polylactide-glycolide copolymer (PGLA).
Patent IL-130931-A0 (IL)
Title: Small molecules useful in the treatment of inflammatory disease
IPC: A61P29/00
Filed: 1998-03-03
Abstract: A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules. Exemplary of the novel compounds are those of structural formulas (a), (b), (c), (d), (e) and (f).
Patent IL-135146-A0 (IL)
Title: Apparatus for repositioning carton flaps
IPC: B65B61/24
Filed: 1998-09-21
Abstract: An apparatus (10) is arranged to reposition substantially front and rear facing flaps (12 and 14) on a carton (16) which is transported along a feed path (18). The apparatus comprises one or more lugs (22) arranged to move around a predetermined locus and is operable such that the or a lug is periodically positioned in the feed path (18) in front of a carton (16) causing the carton (16) to contact the lug (22) and reposition the front flap (12) on the carton (16). The apparatus (10) is further operable periodically to increase the velocity of the lug or lugs (22) so as to bring the or a lug into contact with the rear of the carton (16) thus repositioning the rear flap (14) thereon.
Patent IL-140655-A0 (IL)
Title: Acoustic device using bending wave modes
IPC: H04R1/02
Filed: 1999-07-26
Abstract: An acoustic device, e.g. a loudspeaker, has a transducer (38) coupled via a highly perforate member (36) to an acoustically active area (39) that may be in the form of a skin over part of the highly perforate member. The highly perforate member (36) may be a mesh. Bending waves may be excited in the highly perforate member (36) by the transducer (38) and sound emitted from the acoustically active area (39).
Patent IL-142247-A0 (IL)
Title: Method of treating sickle cell disease and thalassemia
IPC: A61K38/48
Filed: 1999-11-16
Abstract: The present invention provides a method of treatment of sickle cell disease (SCD) or thalassemia with protein C. The claimed invention provides a needed therapy for potentially serious and debilitating disorders while avoiding complications such as bleeding tendency, toxicity and general side effects of currently available anti-coagulant agents.
Patent IL-143734-A0 (IL)
Title: Transfectacons comprising calcium phosphate and a nucleic acid
IPC: C12N1/00
Filed: 1999-12-20
Abstract: A process is described for preparing transfectacons, or particles, of calcium phosphate and a desired nucleic acid comprising admixing calcium divalent cation, phosphate multivalent anion, and the desired nucleic acid to form a precipitation mixture, wherein the precipitation mixture comprises an initial phosphate anion concentration of about 0.2 to 0.5 mM; and incubating the precipitation mixture for about 10 to 60 minutes to form transfectacons comprising calcium phosphate and the desired nucleic acid. A process is also provided for delivering desired nucleic acid to eukaryotic tissue or cells comprising introducing to the tissue or cells the transfectacons so prepared. Additionally, a process is disclosed for introducing a desired nucleic acid into a eukaryotic host cell comprising the above two steps, followed by diluting the precipitation mixture and admixing it with a eukaryotic host cell lacking a cell wall to form a transfection mixture; and incubating the transfection mixture to allow the eukaryotic host cell to take up the transfectacons to form a transfected cell.
Patent IL-144265-A0 (IL)
Title: Use of antibodies for the vaccination against cancer
IPC: C07K16/28
Filed: 2000-01-12
Abstract: Use of an antibody targeted to a human cellular membrane antigen, to manufacture a medicament to prophylactically and/or therapeutically vaccinate against cancer, is new.
Patent IL-147535-A0 (IL)
Title: Method for preparing highly stabilised hydroxylamine solutions
IPC: B01J41/04
Filed: 2000-08-03
Abstract: The present invention relates to a process for the preparation of high-purity, stabilized hydroxylamine solutions in which an aqueous hydroxylamine starting solution is treated with an anion exchanger which has been pre-loaded with a hydroxylamine stabilizer in order to remove anions.
Patent IL-157057-A0 (IL)
IPC: B25F5/02
Filed: 2002-01-22
Abstract: A multi-speed transmission assembly for a rotary power tool. The transmission assembly includes a plurality of transmission stages, with at least two of the transmission stages employing a movable reduction element that permits the transmission stage to be operated in an active mode and an inactive mode. The movable reduction elements are coupled to a switching mechanism that switches the reduction elements in a predetermined manner to provide at least three-gear reduction or speed ratios.
Patent IL-157816-A0 (IL)
Title: Steroids as agonists for fxr
IPC: C07J9/00
Filed: 2002-02-21
Abstract: The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
Patent IL-161654-A0 (IL)
Title: Method of fabricating micro-electromechanical switches on cmos compatible substrates
IPC: H01H59/00
Filed: 2002-11-07
Abstract: A method of fabricating micro-electromechanical switches (MEMS) integrated with conventional semiconductor interconnect levels, using compatible processes and materials is described. The method is based upon fabricating a capacitive switch that is easily modified to produce various configurations for contact switching and any number of metal-dielectric-metal switches. The process starts with a copper damascene interconnect layer, made of metal conductors inlaid in a dielectric. All or portions of the copper interconnects are recessed to a degree sufficient to provide a capacitive air gap when the switch is in the closed state, as well as provide space for a protective layer of, e.g., Ta/TaN. The metal structures defined within the area specified for the switch act as actuator electrodes to pull down the movable beam and provide one or more paths for the switched signal to traverse. The advantage of an air gap is that air is not subject to charge storage or trapping that can cause reliability and voltage drift problems. Instead of recessing the electrodes to provide a gap, one may just add dielectric on or around the electrode. The next layer is another dielectric layer which is deposited to the desired thickness of the gap formed between the lower electrodes and the moveable beam that forms the switching device. Vias are fabricated through this dielectric to provide connections between the metal interconnect layer and the next metal layer which will also contain the switchable beam. The via layer is then patterned and etched to provide a cavity area which contains the lower activation electrodes as well as the signal paths. The cavity is then back-filled with a sacrificial release material. This release material is then planarized with the top of the dielectric, thereby providing a planar surface upon which the beam layer is constructed.
Patent IL-185266-A0 (IL)
Title: Anti-cancer and anti-microbial oxazolidinones and analogues
Filed: 2007-08-14
Abstract: Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.
Patent IL-188457-A0 (IL)
Title: The use of anti-histaminics for acute reduction of elevated intracranial pressure
IPC: A61K31/55
Filed: 2007-12-27
Abstract: The invention concerns the use of an H1- and/or H2-histamine receptor antagonist for the reduction of intracranial pressure (ICP), in particular for the prevention and treatment of elevated intracranial pressure and/or secondary ischaemia, in particular caused by brain injury, more in particular caused by traumatic (TBI) and non-traumatic brain injury. In particular, the histamine antagonist is selected from the group of acrivastine, alimemazine, antazoline, astemizole, azatadine, azelastine, brompheniramine, buclizine, carbinoxamine, carebastine, cetirizine, chlorcyclizine, chlorpheniramine, cinnarizine, clemastine, clemizole, clocinizine, clonidine, cyclizine, cyproheptadine, descarboethoxyloratidine, dexchlorpheniramine, dimenhydrinate, dimethindene, dimethothiazine, diphenhydramine, diphenylpyraline, doxylamine, ebastine, efletirizine, epinastine, fexofenadine, hydroxyzine, ketotifen, levocabastine, loratidine, meclizine, mequitazine, methdilazine, mianserin, mizolastine, niaprazine, noberastine, norastemizole, oxatomide, oxomemazine, phenbenzamine, pheniramine, picumast, promethazine, pyrilamine, temelastine, terfenadine, trimeprazine, tripelennamine, triprolidine, ranitidine, cimetidine, famotidine, nizatidine, tiotidine, zolantidine, ritanserine, and derivatives thereof and mixtures of any two or more of the foregoing.
Patent IL-195320-A0 (IL)
Title: A simple inhaler and method to inhale
Filed: 2008-11-16
Abstract: A dry powder inhaler for pulmonary or nasal use, comprising at least an inhaler body and a cartridge with one or more compartments each containing one dose of a drug. The compartment has holes to admit air and holes to deliver powder, which, in use, communicate with an inhalation channel in the inhaler body. To prevent the powder from leaking through the compartment holes before use, the air admission holes are of reduced dimension, thereby blocking or hindering powder exit under the force of gravity. When the cartridge is inserted inside the inhaler body, all its holes can be blocked. By sliding the cartridge in relation to the body until the inhalation position is reached, the holes come into in fluid communication with one another and with the inhalation channel, thereby allowing a flow of air to disperse and entrain the dose through the mouthpiece. Five embodiments are disclosed.
Patent IL-195572-A0 (IL)
Title: Controlled release formulations
Filed: 2008-11-27
Abstract: The invention relates to a controlled release formulation for an oral cytokine inhibitor of interleukin-1 beta converting enzyme.
Patent IL-196696-A0 (IL)
Title: Capillary membrane filtration module
Filed: 2009-01-25
Abstract: The present invention is related to a filtration device for removing particles from a liquid and its method of production, said filtration device comprising: 
¢ A collector header arranged to collect and remove permeate, 
¢ A plurality of planar membrane assemblies having an upper side and a lower side, said lower side being operatively linked to said collector header, 
¢ Said planar membrane assemblies each comprising a plurality of outside-in micro- or ultrafiltration capillary membranes, each capillary membrane extending from said lower side to said upper side of said planar membrane assembly, said plurality of capillary membranes forming a plane, 
¢ Wherein the capillary membranes of each planar membrane assembly are operatively linked to an individual upper header, and wherein the upper headers of each planar membrane assembly and the disposition of the planar membrane assemblies at the lower side are arranged to allow a flow of air bubbles, crude water and particles to pass from said lower side to said upper side and to reduce particle build-up at said upper side.
Patent RO-132081-A0 (RO)
Title: System for thermally treating, in microwave field, hazardous emissions resulted after electronic-waste pyrolysis
Inventor: FITI ALEXANDRU
IPC: B01D53/32
Filed: 2016-11-22
Abstract: The invention relates to a system for thermally treating polluting emissions resulted after electronic-waste pyrolysis. According to the invention, the system consists of a thermal filter consisting of a cylindrical filter body (1) made of refractory steel, wherein some rectangular openings (6) are made for mounting a microwave irradiation system consisting of an adapting flange (11), the wave guide (12), in assembly with a magnetron (13) with the frequency of 2.45 GHz, the body (1) being provided, at the lower side, with a flange (2), a profiled seat (3) and at the upper side, with a cover (4) and a cone (5) for taking over gases, inside the body (1) there being a quartz tube (7), inside which there is a zirconia-based granular material (9) which is irradiated with power densities of 100...2500 W/kg of granular material, the system being also provided with a Venturi tube (20) mounted after the thermal filter and connected to a computer-programmed thermostatic system.
Patent RO-135973-A0 (RO)
Title: 3d printed structures based on nanostructured hydroxyapatite from rapana thomassiana and collagen
Inventor: ISTRATE SÎNZIANA LUMINIŢA
IPC: A61L27/32
Filed: 2022-05-23
Abstract: The invention relates to a process for manufacturing 3D printed structures based on nanostructured hydroxyapatite and collagen used in bio-engineering for manufacturing ocular implants or prostheses. According to the invention, the process consists of the in-situ hydrothermal synthesis starting from nanostructured hybrid powders based on natural hydroxyapatite from the Rapana Thomasianna shell and collagen, at pressures of 1000 bars and temperatures of 100°C, followed by drying, mixing the powder with commercial grade binders, for the formation of a paste for printing by extrusion, resulting in biocompatible three-dimensional structures with full control of the geometrical parameters, in the form of a cube with a side of 2 cm.
Patent AP-2001002259-A0 (AP)
Title: Oxamic acids and derivatives as thyroid receptor ligands.
Inventor: CHIANG YUAN-CHING PHOEBE
IPC: C07D295/192
Filed: 2000-02-21
Abstract: The present invention provides novel compounds of formula ((i)and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein r1-r8 and w are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts threof, and methods, pharmaceutical compositions and kits for treating obesity, hyperlipidemia, glaucoma, cardiac arrythmia, skin disorders, thyroid disease, hypothyroidism and related disorders and disease such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesterremia, depression and osteoporosis are also provided.
Patent MA-28059-A1 (MA)
Title: Telephone mobile permettant de communiquer avec la voix et les images video
Inventor: EL BOUAZZAOUI MAJID
IPC: H04W28/06
Filed: 2005-01-26
Abstract: Téléphone mobile permettant de communiquer avec la voix et les images vidéo Abrégé du contenu technique de l'invention Téléphone mobile permettant la communication avec la voix et les images vidéo en simultané et en temps réel à travers toutes les infrastructures de réseaux téléphoniques mobiles.
Patent MA-28099-A1 (MA)
Inventor: DARGAZANLI GIHAD
IPC: C07D471/08
Filed: 2006-04-17
Abstract: N-heterocyclylmethyl benzamide derivatives (I) and their acid addition salts, solvates and hydrates are new. N-heterocyclylmethyl benzamide derivatives of formula (I) and their acid addition salts, solvates and hydrates are new. [Image] R : H or vinyl; n : 0 or 1; X : CH or N; R 1 : phenyl or naphthyl optionally substituted by halo, 1-6C alkyl, 1-6C alkoxy or CF 3; or thienyl, pyridyl, oxazolyl, furyl, thiazolyl, quinolinyl or isoquinolinyl; R 2 : H, halo, CF 3, A, OA, thienyl, OAr, SH, SA, SO 2NR 4R 5, SO 2A, SO 2Ar, CN, CONR 4R 5, COOR 7, COA, COAr, NHCOR 8, NHSO 2A, NHSO 2Ar or NHSO 2NR 4R 5; A : 1-6C alkyl optionally substituted by R 3; Ar : phenyl optionally substituted by R 6; R 3 : halo, phenyl, 1-6C alkoxy or NR 4R 5; R 4, R 5 : H or 1-6C alkyl; or NR 4R 5 : pyrrolidino, piperidino or morpholino; R 6 : H, OH, SH, 1-6C alkyl or 1-6C alkoxy; R 7 : H, A or Ar; R 8 : A, 1-6C alkoxy or Ar; and provided that when R is vinyl, then n is 1 and X is CH. ACTIVITY : Nootropic; Neuroleptic; Tranquilizer; Antidepressant; Antialcoholic; Antimigraine; Relaxant; Analgesic; Antiparkinsonian; Anticonvulsant; Neuroprotective. MECHANISM OF ACTION : Glycine transporter inhibitor. The most active compounds (unspecified) have IC50 values of 0.01-10 MicroM against glycine uptake by SK-N-MC cells expressing native human glycine transporter glyt1.
Patent MA-28339-A1 (MA)
Inventor: DEFOSSA ELISABETH
IPC: C07D471/04
Filed: 2006-07-28
Abstract: The invention relates to heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives as well as their physiologically compatible salts and physiologically functional derivatives. The invention concerns compounds of formula (I), wherein the radicals have the cited meanings, and the physiologically compatible salts thereof. The compounds are suited for use, e.g. as medicaments for preventing and treating type 2 diabetes.
Patent MA-20150398-A1 (MA)
Title: Entrepôt modulaire
Inventor: BISELLI GIANLUCA
IPC: F41A9/78
Filed: 2013-12-18
Abstract: La présente invention concerne un entrepôt (1) qui comprend une pluralité de modules d'apport (m), qui délimitent une pluralité de rangées, agencées l'une près de l'autre, chaque rangée ayant un nombre prédéfini de palettes (c) ; au moins une structure (2) de plancher, qui soutient les modules d'apport (m) et définit une surface de marche ; un système mobile destiné à un automate programmable de ces palettes (c), qui comprend une palette (3) se déplaçant en suspension, agencé dans la partie supérieure des modules d'apport (m) et apte à déplacer l'automate programmable dans un plan de référence (xy), de manière à atteindre les palettes (c) uniques. La palette (3) se déplaçant en suspension comprend un treillis (30) horizontal qui, à son tour, comprend un tablier (32), auquel est fixé l'automate programmable. Le treillis (30) horizontal est apte à coulisser le long d'au moins deux guides (31) longitudinaux. Les guides (31) longitudinaux sont fixés rigides aux modules d'apport (m) des rangées externes, qui délimitent l'extension horizontale de l'entrepôt. Chaque module (m) est fixé rigide à la structure (2) de plancher.
Patent MA-38398-A1 (MA)
Title: Composés biaryle amides en tant qu'inhibiteurs de kinase
Inventor: LOU YAN
IPC: C07D413/14
Filed: 2014-03-13
Abstract: La présente invention concerne des composés de formule (i) tels que décrits ici, et leurs sels, et des utilisations thérapeutiques de ces composés pour le traitement de troubles associés à l'activité raf kinase. L'invention concerne en outre des compositions pharmaceutiques comprenant ces composés, et des compositions comprenant ces composés et un co-agent thérapeutique.
Patent MA-45955-A1 (MA)
Title: Systèmes pour fournir une capsule de culture de ligne d’assemblage
Inventor: MILLAR GARY BRET
IPC: A01G31/04
Filed: 2018-06-04
Abstract: La présente invention concerne des systèmes et des procédés pour fournir une capsule de culture de ligne d’assemblage. Un mode de réalisation d’une capsule de culture selon la présente invention comprend une enceinte extérieure qui définit un volume confiné de façon environnementale, une piste qui est formée en une pluralité de structures hélicoïdales définissant un trajet, et un chariot qui reçoit une plante et traverse la piste. Certains modes de réalisation comprennent un capteur pour déterminer la sortie de la plante, une pluralité d’affecteurs environnementaux qui modifient un environnement du volume confiné de façon environnementale pour modifier la sortie de la plante, et un dispositif informatique de capsule qui stocke une recette de culture qui, lorsqu’elle est exécutée par un processeur du dispositif informatique de capsule, actionne au moins l’un de la pluralité d’affecteurs environnementaux. Dans certains modes de réalisation, la recette de culture modifie un actionnement planifié de l’au moins un de la pluralité d’affecteurs environnementaux en réponse à des données provenant du capteur indiquant une sortie actuelle de la plante.
Patent MA-53199-A1 (MA)
Title: Protection durable contre l'encrassement biologique
Inventor: MCMURRAY BRIAN
IPC: G01N31/22
Filed: 2019-11-01
Abstract: L'invention concerne des dispositifs, des procédés et/ou des systèmes destinés à être utilisés dans la protection d'éléments et/ou de structures qui sont exposés à des environnements aquatique, submergés et/ou partiellement submergés dans ceux-ci contre la contamination et/ou l'encrassement dus à l'incursion et/ou la colonisation par des types et/ou des genres spécifiques d'organismes et/ou de plantes biologiques, y compris la protection contre les micro- et/ou macro-salissures pendant des périodes prolongées d'exposition à des environnements aquatiques.
Patent UY-23684-A1 (UY)
Title: Procedimiento para la preparacion de nueva sulfamida
Inventor: BREU VOLKER
IPC: A61K31/535
Filed: 1993-12-09
Abstract: Procedimiento para la preparación de compuestos de fórmula general (I), nuevas sulfonamidas y sus sales, representadas en la figura 1, donde: R1 representa hidrógeno, alquilo inferior, alcoxilo inferior, alquiltio inferior, halógeno o trifluorometilo; R2 representa hidrógeno, alquilo inferior, halógeno, alcoxilo inferiro, trifluorometilo, u -OCH2COOR9; R3 representa hidrógeno, alquilo inferior, halógeno, alquiltio inferiro, triifluorometilo, alcoxilo inferiro o trifluorometoxilo, o; R2 Y R3 juntos representan butadienilo, metilendioxilo, etilendioxilo o isopropilidendioxilo; X representa -O- o -S-; R5 a R8 representan hidrógeno, halógeno, trifluorometilo, alcoxilo inferiro, alquiltio inferiro o ciano; y R5 o R7 juntos representan butadienilo, metilendioxilo, etilendioxilo o isopropilidendioxilo. El procedimiento consta de: a-	hacer reaccionar un compuesto de fórmula (II) representado en la figura 2, con un compuesto de fórmula general R12AM, donde A es oxígeno o azufre y M es un metal alcalino, para dar un compuesto de fórmula (I) donde Y es un radical OR12 o SR12; o b-	hacer reaccionar un compuesto de fórmula (IV) representado en la figura 3, con un compuesto de fórmula (V) representado en la figura 4, para dar un compuesto de fórmula (I) donde Y es un radical R10 y R1-R8; o c-	hacer reaccionar un compuesto de fórmula (VI) representado en la figura 5, con un compuesto de fórmula (VII) representado 6, y si se desea convertir el compuesto de fórmula (I) obtenido en una sal. Ejemplo no limitante de un compuesto de fórmula (I): 4-tercibutil-N-[6-etoxi-5-(2-metoxifenoxi)-2,2'-bipirimidin-4-il]bencensulfonamida. Estos compuestos descritos son inhibidores de receptores de endotelin, por tanto son útiles en el tratamiento y trastornos asociados a los mismos, como la hipertensión, isquemia, vasoespasmos y angina de pecho.