Patent SG-11201900349V-A (SG)
Title: Somatostatin modulators and uses thereof
Inventor: ZHAO JIAN
IPC: C07D401/04
Filed: 2017-07-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#1110111101110101011111 vu 1101 0 0111111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/013676 Al 18 January 2018 (18.01.2018) W I P0 I P C T (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7D 401/04 (2006.01) A61K 9/20 (2006.01) KM, ML, MR, NE, SN, TD, TG). A61K 31/502 (2006.01) A61K 9/48 (2006.01) A61K 31/4725 (2006.01) Declarations under Rule 4.17: (21) International Application Number: — as to applicant's entitlement to apply for and be granted a PCT/US2017/041694 patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the (22) International Filing Date: earlier application (Rule 4.17(iii)) 12 July 2017 (12.07.2017) Published: (25) Filing Language: English — with international search report (Art. 21(3)) (26) Publication Language: English — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of (30) Priority Data: amendments (Rule 48.2(h)) 62/362,493 14 July 2016 (14.07.2016) US 62/411,338 21 October 2016 (21.10.2016) US (71) Applicant: CRINETICS PHARMACEUTICALS, INC. [US/US]; 6197 Cornerstone Court, Suite 111, San Diego, California 92121 (US). (72) Inventors: ZHAO, Jian; 6197 Cornerstone Court, Suite _ 111, San Diego, California 92121 (US). HAN, Sangdon; 6197 Cornerstone Court, Suite 111, San Diego, California = 92121 (US). KIM, Sun Hee; 6197 Cornerstone Court, Suite 111, San Diego, California 92121 (US). WANG, Shimiao; =_ 6197 Cornerstone Court, Suite 111, San Diego, California 92121 (US). ZHU, Yunfei; 6197 Cornerstone Court, Suite 111, San Diego, California 92121 (US). Agent: ZUNIC, Valentin B.; Wilson Sonsini Goodrich & (74) = = Rosati, 650 Page Mill Road, Palo Alto, California 94304 (US). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, — DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = = OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = — SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — 1-1 IN UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, M 1-1 O_ 0 (54) Title: SOMATOSTATIN MODULATORS AND USES THEREOF 1-1 0 (57) : Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical ei compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, 0 diseases, or disorders that would benefit from modulation of somatostatin activity.