baber/WOPTO huggingface dataset:
Patent CA-2530668-A1 (CA)
Inventor: PREVOST GREGOIRE
IPC: C07D277/64
Filed: 2004-06-24
Abstract: L'invention a pour objet un produit comprenant au moins un inhibiteur de phosphatase Cdc25 en association avec au moins un autre agent anti-cancéreux pour une utilisation thérapeutique simultanée, séparée ou étalée dans le tem ps dans le traitement du cancer. Selon l'invention, l'autre agent anti-cancéreu x est de préférence choisi parmi : des analogues de bases de l'ADN comme le 5- fluorouracyle ; des inhibiteurs de topoisomérases de type I et/ou II comme p ar exemple la camptothécine et ses analogues, la doxorubicine ou l'amsacrine ; des composés interagissant avec le fuseau cellulaire comme par exemple le paclitaxel (Taxol) ; des composés agissant sur le cytosquelette comme la vinblastine ; des inhibiteurs de la transduction du signal passant par les protéines G hétérotrimériques ; des inhibiteurs de prényltransférases, et en particulier les inhibiteurs de farnésyltransférases ; des inhibiteurs des kinases dépendantes des cyclines (CDKs) ; des agents alkylants comme le cisplatine ; des antagonistes de l'acide folique comme le méthotrexate ; et des inhibiteurs de la synthèse de l'ADN et de la division cellulaire comme l a mitomycine C. L'invention a encore pour objet la (1R)-1-[({(2R)-2-amino-~3- [(8S)-8-(cyclohexylméthyl)-2-phényl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)- yl]~-3-oxopropyl}dithio)méthyl]-2-[(8S)-8-(cyclohexylméthyl)-2-phényl~-5,6- dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-2-oxoéthylamine, ou ses sels pharmaceutiquement acceptables, utiles en tant qu'agents anti-cancéreux.</SD OAB>
Patent CA-2530688-A1 (CA)
Inventor: SUN LEI
IPC: B23K26/38
Filed: 2004-05-05
Abstract: A laser (126) and an AOM (10) are pulsed at substantially regular and substantially similar constant high repetition rates to provide working laser outputs (40) with variable noimpingement intervals (50) without sacrificing laser pulse-to-pulse energy stability. When a working laser output (40) is demanded, an RF pulse (38) is applied to the AOM (10) in coincidence with the laser output pulse (24) to transmit the laser pulse to a target. When no working laser output (40) is demanded, an RF pulse (38) is applied to the AOM  (10) in noncoincidence with the laser output (24), so that the laser pulse is blocked. Thus, the average thermal loading on the AOM (10) remains substantially constant regardless of how randomly the working laser outputs (40) are demanded. The AOM (10) can also be employed to control the energy of the working laser output (40) by controlling the power of the RF pulse (38) applied. When the RF power is changed, the duration (44) of the RF pulse (38) is modified to maintain the constant average RF power.
Patent CA-2532618-A1 (CA)
Inventor: DOWNTON GEOFF
IPC: E21B21/10
Filed: 2006-01-12
Abstract: Methods and apparatuses to direct a drill bit of a directional drilling assembly are disclosed. The methods and apparatuses employ the use of bi-directional actuators that are capable of displacing a hybrid steering sleeve in positive and negative directions. The bi-directional actuators are capable of greater control and precision in their actuations than traditional "engaged-disengaged" unidirectional actuators, thereby allowing for more precise directional drilling operations. The bi-directional actuators are preferably driven by drilling fluids and may optionally be shielded to lessen the erosive effects thereof.
Patent CA-2533351-A1 (CA)
Inventor: LAMPUS DONALD I
IPC: B28B23/00
Filed: 2004-07-26
Abstract: Disclosed is an insert apparatus (10) for a mold (110) for manufacturing structural units (100). The insert apparatus (10) includes a carrier (12) for operatively engaging a portion of the mold (110), and a face (14) having a design portion (16) thereon. The face (14) is in operative communication with the carrier (12), and the design portion (16) extends into or out of an inner cavity (112) of the mold (100). A method of manufacturing such a structural unit (100), a method of retrofitting an existing mold (110) for manufacturing such a unit (100) and a method of installing a wall (18) using the structural units (100) are also disclosed.
Patent CA-2534844-A1 (CA)
Title: Particle detection
Inventor: TOUTOUNGI DANIELLE EMMA
IPC: G01R29/14
Filed: 2004-09-03
Abstract: Particle detection and characterising apparatus has an insulating tube (50) along which the particles flow. Five electrodes (51, 52, 55, 56) and (57) spaced along the outside of the tube are connected via amplifiers (61) and (62) to a processor (68) arranged to measure the charge on the particles. The apparatus also includes a laser (11) and photomultiplier tube (23) arranged to measure the size of the particles so that the nature of the particles can be characterised from their electrical charge and size.
Patent CA-2534898-A1 (CA)
Inventor: HSING-CHANG CHIEN
IPC: C07K16/46
Filed: 2004-08-09
Abstract: The bispecific antibodies of the present invention are in the form of a heteroconjugate that inhibits growth and induces apoptosis of a diseased cell and that does not require the recruitment of effector cells. The heteroconjugate has at least two binding arms wherein each of the binding arms possesses a different specificity and need not have apoptotic activity when not conjugated to each other. Also provided are methods of treating and diagnosing a diseased cell using the bispecfic antibodies of the present invention.
Patent CA-2535566-A1 (CA)
Title: Microfluidic large scale integration
Inventor: STUDER VINCENT
IPC: F15C5/00
Filed: 2004-08-10
Abstract: Using basic physical arguments, a design and method for the fabrication of microfluidic valves using multilayer soft lithography is presented.  Embodiments of valves in accordance with the present invention feature elastomer membrane portions of substantially constant thickness, allowing the membranes to experience similar resistance to an applied pressure across their entire width. Such on-off valves fabricated with upwardly- or downwardly-deflectable membranes can have extremely low actuation pressures, and can be used to implement active functions such as pumps and mixers in integrated microfluidic chips. Valve performance was characterized by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and comparing them to both finite element simulations and alternative valve geometries.
Patent CA-2537632-A1 (CA)
Inventor: CHOI MYUNG CHAN
IPC: G11C7/02
Filed: 2004-09-03
Abstract: Circuits and methods are described for reducing leakage current and speeding access within dynamic random access memory circuit devices. A number of beneficial aspects are described. A circuit is described for an enhanced sense amplifier utilizing complementary drain transistors coupled to the sense or restore signals and driven by gate voltages which extend outside of the voltage range between Vss and VDD. The drain transistors are self reverse-biased in a standby mode. A method is also described for reducing leaking in non-com plementary sense amplifiers by modifying the sense and restore gate voltages. Another aspect is a new negative word line method utilizing stacked pull-down transistors and a multistep control circuit. In addition a level shifter scheme is described for preventing unwanted current flow between voltage sources while discharging control signal PX.
Patent CA-2538642-A1 (CA)
Inventor: NOVIELLO FLAVIO
IPC: D06F58/20
Filed: 2006-03-06
Abstract: Clothes drying machine comprising a drum holding the clothes to be dried, a first fan adapted to blow a first flow of drying air through said drum, and possibly a condenser adapted to condense the moisture out of the drying air exiting said drum. The machine is provided with a drying programme that includes a step involving an increase in the temperature of the air introduced in said drum, in which said temperature is increased to a value of at least 130°C and held there for a pre-set period of time, and said temperature increase step is provided in the initial portion of the drying programme, when the moisture content of the clothes is not less than 20%.
Patent CA-2538846-A1 (CA)
Inventor: CUTFIELD WAYNE STEPHEN
IPC: A61K38/00
Filed: 2004-09-14
Abstract: The application relates to the treatment of conditions and diseases for which growth hormone is a desirable method of treatment, using free fatty acid regulators in combination with growth hormone. In particular, the present invention discloses an enhanced method of treatment of growth disorders as well as methods to prevent and/or reduce adverse consequences of growth hormone treatment.
Patent CA-2540128-A1 (CA)
Title: Quantification schemes for quantifying nucleic acids
Inventor: PINSL-OBER JUDITH
IPC: G06F19/00
Filed: 2004-09-24
Abstract: Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample.  The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common amplification process; measuring a quantity indicating the amount of amplification product for the target and for the control in relation to a parameter representing the progress of the amplification; determining a characteristic value of the progress parameter for the target based on measurement results related to the amount of target amplification product; possibly determining a characteristic valuc of the progress parameter for the control based on measurement results related to the amount of control amplification product; and quantifying the original amount of target according to a predefined or selected quantification scheme using at least the characteristic value for the target.
Patent CA-2540229-A1 (CA)
Inventor: LEPAGE GAETAN
IPC: B27B9/04
Filed: 2006-03-15
Abstract: A guide device for circular saw, which includes a longitudinally extending elongated flat plate which is provided for mounting a square and a guide rail, of which a guide roller secured to the base plate of the circular saw slides thereon for longitudinal movement therealong.
Patent CA-2541630-A1 (CA)
Title: A method and a device for reconfiguration in a wireless system
Inventor: SEBIRE BENOIST
IPC: H04L1/00
Filed: 2003-10-06
Abstract: A method and a device for reconfiguration in a wireless system utilizing flexible layer one (FLO). In proposed solution one TFC (Transport Format Combination) is selected and reserved (504) exclusively for signalling use.  The TFC may contain only one active transport channel and always utilize the same CRC and transport block size in order to unambiguously define the proper settings for signalling. Considering uplink transmission in a wireless system and special case of TFCI (Transport Format Combination Identifier) size change due to the TFCS (Transport Format Combination Set) reconfiguration that also generates a need to switch to a new dedicated basic physical subchannel (DBPSCH); whenever the network notices that the mobile station does not switch to the new DBPSCH (518), it concludes that the TFCS reconfiguration message sent was lost and stays with the existing configuration (520). Otherwise the new configuration is taken into use (514).
Patent CA-2542779-A1 (CA)
Inventor: FIELDER NICHOLAS ALBERT WILLIA
IPC: B60G21/067
Filed: 2004-10-15
Abstract: A vehicle suspension control for a vehicle having each wheel (11) supported from the chassis of the vehicle trough a fluid operated extension element (13, 19), the control comprising a controller (27), a plurality of sensors (21, 23, 25, 27, 30, 32), a fluid flow controller (29), a first sensor (2 1) adapted to sense the relative position between the wheel (11) and the chassis and provide a first output to the controller, a second sensor (23) adapted to sense the pressure of the fluid in each extension element (13, 19) and provide a second output to the controller (27) adapted to receive the output from each of the sensors (21, 23) at each wheel, process the outputs and provide a wheel output to the fluid flow controller (29) for each wheel, the force applied by the extension elements (13, 19) between the chassis and wheels will maintain the attitude of the chassis substantially constant relative to a plane.
Patent CA-2543281-A1 (CA)
Title: Hydrogenolysis of sugar feedstock
Inventor: TYERS DEREK VINCENT
IPC: C07C29/141
Filed: 2004-10-15
Abstract: A process for the hydrogenolysis of a sugar feedstock in the presence of a catalyst comprising: (a) ruthenium or osmium; and (b) an organic phosphine;  and wherein the hydrogenolysis is carried out in the presence of water and at a temperature of greater than 150 ~C.
Patent CA-2546870-A1 (CA)
Inventor: BASQUE ROLAND
IPC: B23K26/42
Filed: 2004-11-24
Abstract: The invention is specially directed towards intermittent motion packaging machines where the packages are momentarily immobilized at a forming station for the time duration of the package sealing and cutting. The polymeric sheets or films (24) are sealed and cut after being exposed to a laser beam (20) in a controlled and optimized manner. The laser beam (20) is shaped with appropriate optical elements (56) to provide a desired intensity profile in the section of the films to be sealed or sealed and cut. With this method, a package (15) can be sealed and cut simultaneously in one exposure step. An optical clamp (30, 31) holds the films (40, 41) together while they are being sealed by the laser (20). The optical clamp (30, 31) can reflect back to the films, partially or totally, the laser beam intensity that has not been previously absorbed. The optical clamp (30, 31) further allows to monitor the sealing and cutting process while the process is being performed.
Patent CA-2553930-A1 (CA)
Inventor: BRANDSTADTER STEPHAN M
IPC: C09K23/52
Filed: 2005-01-28
Abstract: Production processes and systems are provided that include reacting halogenated compounds, dehalogenating compounds, reacting alcohols, reacting olefins and a saturated compounds, reacting reactants having at least two -CF3 groups with reactants having cyclic groups. RF~ compositions such as RF-intermediates, RF-surfactants, RF-monomers, RF-~monomer units, RF-metal complexes, RF-phosphate esters, RF-glycols, RF~ urethanes, and/or RF-foam stabilizers. The RF portion can include at least two -CF3 groups, at least three -CF3 groups, and/or at least two -CF3 groups and at least two -CH2-groups. Detergents, emulsifiers, paints, adhesives, inks, wetting agents, foamers, and defoamers including the RF-surfactant composition are provided.  Acrylics, resins, and polymers are provided that include a RF-monomer unit.  Compositions are provided that include a substrate having a RF-composition thereover. Aqueous Film Forming Foam ("AFFF") formulations are provided that can include RF-surfactants and/or RF-foam stabilizers are provided.
Patent CA-2558924-A1 (CA)
Inventor: HAASL ANDREW L
IPC: B65H5/22
Filed: 2006-09-07
Abstract: A sheet supply system, for use in supplying overlapped sheets to an interfolder, includes a bed roll on which a web is cut into successive sheets. The sheets are supplied to a sheet supply passage leading to retard rolls, which overlap the sheets within the supply passage. The trailing portion of each downstream sheet bulges outwardly as the sheet is supplied to the supply passage. An air tube directs pressurized air into a volume within which the bulge in the downstream sheet is formed. The pressurized air prevents the leading portion of the upstream sheet from being drawn outwardly along with the trailing area of the downstream sheet, by counteracting a vacuum that results from outward movement of the trailing portion of the downstream sheet after it is released from the bed roll. The pressurized air also maintains the upstream sheet in engagement with stripper fingers that guide the sheets through the sheet supply passage, and ensures separation between the trailing end of the downstream sheet and the leading end of the upstream sheet.
Patent CA-2560827-A1 (CA)
Title: Preventing arrhythmias associated with cell transplantation
Inventor: MARBAN EDUARDO
IPC: A61K48/00
Filed: 2005-03-22
Abstract: Skeletal myoblasts are an attractive cell type for transplantation since they are autologous and resistant to ischemia. However, clinical trials of myoblasts transplantation in heart failure have been plagued by ventricular tachy-arrhythmias and sudden cardiac death. The pathogenesis of these arrhythmias is poorly understood, but may be related to the fact that skeletal muscle cells, unlike heart cells, are electrically isolated by the absence of gap junctions. An in vitro model of myoblasts transplantation into cardiomyocyte monolayers can be used to investigate the mechanisms of transplant-associated arrhythmias. Co-cultures of human skeletal myoblasts and rat cardiomyocytes result in reentrant arrhythmias (spiral waves) that reproduce the features of ventricular tachycardia seen in patients receiving myoblasts transplants. These arrhythmias can be terminated by nitrendipine, an L-type calcium channel Mocker, but not by the Na channel blocker lidocaine.  Genetic modification of myoblasts to stably express the gap junction protein connexin 43 decreases arrhythmogenicity in co-cultures. It similarly can be used to increase the safety of myoblasts transplantation in patients.
Patent CA-2569022-A1 (CA)
Title: Apparatus and method for encoding or decoding interlace or progressive scanned picture
Inventor: TAKAHASHI KUNIAKI
IPC: H04N19/59
Filed: 2005-06-03
Abstract: A picture of sequential scanning is displayed in such a manner that its vertical resolution is not deteriorated. In a picture encoder apparatus (101), a result of determining whether the picture is of interlaced scanning or sequential scanning is set in a scan flag, and information indicative of a picture display system is set in display system indicating information. The picture encoder apparatus (101) then outputs encoded data in which they have been multiplexed. In a picture decoder apparatus (102), the picture is recognized based on the scan flag and display system indicating information of the encoded data. If the picture is of interlaced scanning, it is field interpolated, thereby generating and outputting a frame picture. If the picture is of sequential scanning, it is repetitively outputted, as a frame picture, a number of times corresponding to the display system indicating information. The present invention is applicable to a case of encoding/decoding pictures, for example, in accordance with H.264/AVC.
Patent CA-2571236-A1 (CA)
Title: Heat exchanger with header tubes
Inventor: COSTEN MICHAEL K
IPC: F02C7/10
Filed: 2005-06-20
Abstract: A heat exchange cell for use in a recuperator includes top and bottom plates spaced apart to define therebetween an internal space. Within the internal space are inlet and outlet header tubes communicating with a plurality of internal matrix fins. The header tubes are rigidly affixed to at least one adjacent header tube and to the top and bottom plates. The header tubes may have a rectangular cross-section and may, for example, be metallurgically bonded to the top and bottom plates and to each other through brazing. Rigidly affixing the header tubes to each other reduces the stress on the fillets that bond the tubes to the top and bottom plates. This in turn permits less structural material to be used in the header portions of the cell and reduces pressure drop across the headers.
Patent CA-2572603-A1 (CA)
Inventor: GOUPIL DENNIS W
IPC: A61L27/52
Filed: 2005-06-29
Abstract: A prosthetic spinal disc nucleus pulposus formed from a hydrogel formed by crosslinking a macromer having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups and an amphiphilic comonomer.
Patent CA-2580785-A1 (CA)
Title: Methode a base d'en-tete de groupe permettant d'organiser un groupe d'homologues locaux de vehicules pour communication inter-vehicules
Inventor: CHEN WAI
IPC: H04L12/28
Filed: 2006-10-27
Abstract: L'invention concerne un procédé destiné à établir et à maintenir le réseau et un dispositif mobile ad-hoc correspondant vis-à-vis d'un réseau à dispositif mobile ayant une pluralité de dispositifs mobiles groupés en un groupe d'homologues local (LPG). Un noeud d'en-tête de groupe (GH) est sélectionné à partir d'une pluralité de dispositifs sans fil mobiles dans le LPG. Le GH commande et gère le LPG par diffusion d'une pluralité de messages de commande, y compris un message de rythme cardiaque à intervalle fixe. Le LPG comprend également au moins un noeud de groupe (GN). Au moins un GN peut communiquer avec le GH via une liaison réseau créée entre au moins un GN et le GH. Les GN relient le LPG via le GH. S'il y a plus de un GH dans un LPG, la résolution d'en-tête a lieu pour ne sélectionner qu'un GH.
Patent CA-2581244-A1 (CA)
Inventor: ALGUEERA JOSE
IPC: B60D1/64
Filed: 2005-09-03
Abstract: A method for the transmission of electrical, pneumatic, or hydraulic energy between a first vehicle and a second vehicle, coupled thereto, for example a tractor vehicle and a trailer and an energy transmission system. The aim of the invention is development of a method and an energy transmission system permitting an operationally-secure driving condition over a long period even with a partly or completely damaged plug coupling system. Said aim is achieved by means of, amongst other things, a method whereby the energy in the energy distribution line is introduced from the energy supply line in a controlled manner.
Patent CA-2581252-A1 (CA)
Title: Tsa process
Inventor: MULLER RALF
IPC: B01D53/04
Filed: 2007-03-07
Abstract: In a TSA process of an at least two-component raw gas, to adjust for fluctuation in load, the cycle time of at least one method step is extended in the event of falling below the design load value.
Patent CA-2581861-A1 (CA)
Title: System for automatically moving access barriers and methods for adjusting system sensitivity
Inventor: MAMALOUKAS JASON L
IPC: G07C9/00
Filed: 2005-10-06
Abstract: An operator system and related methods for automatically controlling access barriers including a controller associated with at least one access barrier and a transceiver associated with the controller for transmitting and receiving operational signals. The system also includes at least one proximity device capable of communicating operational signals with the transceiver based upon a position of the proximity device with respect to the barrier and/or the operational status of a vehicle carrying the proximity device, wherein the controller monitors the operational signals and controls the position of the access barrier based upon the operation signals. Such a system allows for hands-free operation of the access barrier.
Patent CA-2585723-A1 (CA)
Title: Method and device for content information sharing
Inventor: MA LEI
IPC: G06F17/30
Filed: 2005-12-22
Abstract: A method and device for content information sharing is provided. The method comprises a first device receiving a content information request from at least a second device via a network, said content information request comprises the capability information of the second device; said first device retrieving the information of the content that the first device could provide; said first device filtering the content information of the content that the first device could provide according to the capability information of the second device; and said first device sending the filtered content information of the content that the first device could provide to the second device. According to the present invention, every device could select to obtain the content information or the content that the device could process or display.