Patent SG-11201407600U-A (SG)
Title: Novel process for preparation of antibody conjugates and novel antibody conjugates
Inventor: BURT JOHN
IPC: C07K16/32
Filed: 2013-06-19
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 December 2013 (27.12.2013) WIPOIPCT (10) International Publication Number WO 2013/190292 A3 (51) International Patent Classification: A61K 47/48 (2006.01) C07K16/32 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/GB2013/051593 (22) International Filing Date: 19 June 2013 (19.06.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1210838.7 19 June 2012 (19.06.2012) GB 1306706.1 12 April 2013 (12.04.2013) GB (71) Applicant: POLYTHERICS LIMITED [GB/GB]; The London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH (GB). (72) Inventors: BURT, John; Polytherics Limited, The London Bioscience Innovation Centre, 2 Royal College Street, __ London NW1 0NH (GB). GODWIN, Antony; Polytherics Limited, The London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH (GB). BADES- CU, George; Polytherics Limited, The London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH (GB). __ (74) Agents: SCOTT, Susan Margaret et al.; Abel and Imray, 20 Red Lion Street, London WC1R 4PQ (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date publication of of the international search report: 20 March 2014 CJ o\ CJ o 0\ i-H o CJ (54) Title: NOVEL PROCESS FOR PREPARATION OF ANTIBODY CONJUGATES AND NOVEL ANTIBODY CONJUG- O ATES (57) Abstract: The present invention concerns process a for the preparation of an antibody conjugate comprising the step of reacting an engineered antibody having single inter-heavy chain a disulfide bond with conjugating a reagent that forms bridge between a the two cysteine residues derived from the disulfide bond.