baber/WOPTO huggingface dataset:
Patent CA-2435954-C (CA)
Title: Preparation of non-crystalline atorvastatin calcium
Inventor: SORSAK GORAZD
IPC: A61K31/40
Filed: 2002-01-22
Granted: 2008-06-03
Abstract: Atorvastatin calcium, the substance known by the chemical name [(R-(R*,R*)]- 2- (4-fluorophenyl)-b,ddihydorxy-5-(1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt is kno wn as HMG-CoA reductase inhibitor and is used as an antihypercholesterolemic agent. Atorvastatin is usually prepared as its calcium salt since it enable atorvastatin to be conveniently formulated in the pharmaceutical formulation s, for example, in tablets, capsules, powders and the like for oral administration. Atorvastatin calcium can exist in an amorphous form or in on e of the crystalline forms (Form I, Form II, Form III and Form IV). Atorvastating calcium is the substance which is very slightly water-soluble, and it has been found that the crystalline forms are less readily soluble th an the amorphous form which may cause problems in the bioavailability of atorvastatin in the body. The present invention relates to a novel process f or converting the intermediate in the synthesis of atorvastatin having the following formula (I) or atorvastatin lactose into the non-crystalline atorvastatin calcium: wherein A denotes a common protection group or separat e protection groups for the dihydroxy group and B denotes a carboxylic acid protection group.
Patent CA-2448864-C (CA)
Title: Pharmaceutical compositions containing a solid dispersion of a poorly-soluble drug in a matrix and a solubility-enhancing polymer
Inventor: SHANKER RAVI MYSORE
IPC: A61K9/14
Filed: 2002-05-13
Granted: 2008-04-22
Abstract: A pharmaceutical composition comprises a dispersion comprising a low- solubility drug and a matrix combined with a concentration-enhancing polymer . At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
Patent CA-2454605-C (CA)
Inventor: ZHA XIANGMING
IPC: G01N30/72
Filed: 2002-06-20
Granted: 2006-11-07
Abstract: The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide. Also provided are an immunoaffinity isolation device comprising a modification-specific antibody, and antibodies against novel UFD1 and PTN6 phosphorylation sites.
Patent CA-2456956-C (CA)
Inventor: FUKUSHIMA YOSHIHIKO
IPC: B60R25/31
Filed: 2002-08-02
Granted: 2008-09-02
Abstract: A mobile communication device (3) can be disconnected form a vehicle monitoring apparatus (1) arranged on vehicle for sensing the state of the vehicle as a monitoring object and transmitting sensing data representing the sensing result. The mobile communication device (3) can also be connected via a communication network (4) to a report destination. The mobile communication device (3) includes a judgment unit (41a) for judging the state of the vehicle according to the sensing data, a decision unit (41b) for deciding a report destination to be connected according to the judgment result of the judgment unit (41a), and a communication unit (42) for receiving the sensing data and establishing a connection with the report destination decided by the decision unit (41b). Thus, it is possible to report the abnormal state of the vehicle sensed to an appropriate report destination in a short time.
Patent CA-2467704-C (CA)
Inventor: REDMOND JOHN D
IPC: F16H57/00
Filed: 2002-11-07
Granted: 2009-01-27
Abstract: The invention comprises a belt drive system and toothed idler sprocket havin g an arcuate pitch to significantly reduce noise. The toothed idler sprocket having a pitch sufficient to cause proper engagement between a belt and the sprocket at a minimal belt wrap angle.
Patent CA-2472540-C (CA)
Title: Hydraulic turbine with enhanced dissolved oxygen
Inventor: DESY NORMAND
IPC: F03B11/00
Filed: 2004-06-25
Granted: 2011-08-09
Abstract: A hydraulic turbine is adapted to introduce oxygen into a water flowing through a water passageway of a turbine. The turbine has a circumferential chamber formed between a rotating band and a stationary discharge ring. The chamber has a gas admission aperture for receiving an oxygen containing gas into the chamber. A downstream end portion of the band has a plurality of spaced apart vanes providing chamber outlet passageways between the vanes and through the band. The vanes are configured to rotate with the band and to draw the oxygen containing gas and water from the chamber through the outlet passageways in the band and into the water passageway.
Patent CA-2473968-C (CA)
Title: Target tire pressure learning method
Inventor: CLAUSSEN STEPHEN P
IPC: B60C23/00
Filed: 2002-11-26
Granted: 2011-01-25
Abstract: A target tire pressure learning method wherein tire pressure is ascertained via a central pressure sensor. The method of learning a target tire pressure for a tire maintained by a tire pressure maintenance system, having conduit assemblies for conducting fluid to and/or from the tire and a pressure sensor for ascertaining fluid pressure in the conduit assemblies, according to the invention includes ascertaining a current tire pressure with the pressure sensor and designating the current tire pressure as a target tire pressure.
Patent CA-2479745-C (CA)
Title: Roller hub with cover and loading device
Inventor: MARTIN FLOYD E
IPC: A47L13/56
Filed: 2003-03-03
Granted: 2011-04-26
Abstract: A roller hub (250) that is designed to fit standard roller frames (102) and a grid (400) that matches the shape of the hub (250). The paint loading surface of the hub (250) has two surfaces (210, 220) that are oriented on a generally 90-degree angle. The intersection of the surfaces is adapted to allow a channel for excess paint to flow when the roller is loaded and pressed into operation in a corner. A removable, reusable cover (300) that slips over the hub (250) is held in place by material with a high degree of elasticity. The length or thickness of the nap (330) on the edges of the cover (300) can be shorter than the length or thickness of the nap (350) in the middle, thereby allowing more paint to be loaded in the area of the roller where it is most needed.
Patent CA-2482448-C (CA)
Title: Preservation of bioactive materials by freeze dried foam
Inventor: TRUONG-LE VU
IPC: A61K39/00
Filed: 2003-04-10
Granted: 2014-07-08
Abstract: This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at temperatures near the phase transition temperature of the membranes.
Patent CA-2486119-C (CA)
Title: Method of isolating an endothelial cell and method of donor specific crossmatching
Inventor: SUMITRAN-HOLGERSSON SUCHITRA
IPC: C12N5/08
Filed: 2003-05-16
Granted: 2011-01-04
Abstract: Method of isolating an endothelial cell from a biological sample using detection reagent specific against an endothelial cell surface receptor (e.g.  Tie-2). This isolated endothelial cell can be used in the detection of endothelial cell antibodies, this has been proven clinically important for successful organ transplantation. Disclosed are therefore also methods of isolating endothelial cell antibodies for donor-specific crossmatching.
Patent CA-2489123-C (CA)
Title: Urilisation d'un modificateur de chlathrate pour favoriser le passage de proteines pendant la nanofiltration
Inventor: ROSENBLATT BARRY P
IPC: B01D61/04
Filed: 2003-06-04
Granted: 2011-03-15
Abstract: La présente invention concerne le domaine de la purification des protéines et la récupération de gros matériaux protéiniques au travers de filtres d'exclusion à petits pores nanométriques, de façon à retirer des contaminants tels que des virus pathogènes.
Patent CA-2490936-C (CA)
Title: Procede et appareil de determination de l'isotropie transversale d'ondes equivolumiques d'une formation terrestre a partir de mesures d'ondes de stoneley d'un puits de forage
Inventor: TANG XIAO MING
IPC: G01V1/50
Filed: 2003-06-26
Granted: 2009-09-15
Abstract: La présente invention se rapporte à un procédé de détermination de la vitesse des ondes équivolumiques horizontales d'une formation, de l'isotropie transversale de la formation et d'un module efficace d'un appareil de diagraphie. Ledit procédé consiste à déterminer un module efficace d'un appareil de diagraphie en modélisant ledit appareil de diagraphie en tant que coque cylindrique remplie de fluide. Des valeurs de lenteur d'ondes de Stoneley mesurées sont acquises pour une formation. Une vitesse des ondes équivolumiques d'une formation horizontale, <i>V<sb>sh</sb></i><sb> </sb>, est calculée en fonction de la lenteur des ondes de Stoneley mesurée et d'une lenteur estimée des longueurs de Stoneley, ladite lenteur estimée des ondes de Stoneley moyennes est calculée au moyen du module efficace de l'appareil. Une différence entre la lenteur des ondes de Stoneley mesurée et la lenteur des ondes de Stoneley estimée est minimisée et la valeur de vitesse des ondes équivolumiques horizontales associée à la différence minimisée est délivrée en sortie. L'isotropie transversale peut ensuite être calculée en fonction de la valeur <i>V<sb>sh</sb></i> déterminée et de la vitesse des ondes équivolumiques verticales <i>V<sb>sh </sb></i>déterminée au moyen de techniques de diagraphie normalisées.
Patent CA-2494061-C (CA)
Inventor: DANTER WAYNE R
IPC: A61K31/506
Filed: 2003-07-31
Granted: 2011-06-14
Abstract: L'invention concerne des composés de formule (I), des sels et des stéréosisomères de ces composés, acceptables sur le plan pharmaceutique, qui inhibent, régulent et/ou modulent la transduction du signal de tyrosine kinase, des compositions contenant ces composés ainsi que des procédés d'utilisation afin de traiter des maladies et des troubles, chez un mammifère, dépendant de la tyrosine kinase. Dans cette formule, N représente un entier, de préférence égal à 1, R¿1? et R¿2? représentent, de manière indépendante, un groupe sélectionné parmi l'ensemble comprenant: dans lequel R¿3? représente un groupe sélectionné dans l'ensemble comprenant H, alkyle, alcényle, alkynyle, halogène, aryle, hétéroaryle contenant N, O ou S, l groupe aryle ou hétéroaryle pouvant être éventuellement substitué avec un groupe halogène, alkyle, alcényle, et alkynyle, NZ¿1?Z¿2?, dans lequel Z¿1? et Z¿2? représentent, de manière indépendante, un groupe sélectionné dans l'ensemble comprenant H et alkyle, et (CO)Y dans lequel Y représente un groupe sélectionné dans l'ensemble comprenant H, alkyle, alcényle, alkynyle, aryle, hétéroaryle contenant N, O ou S, les groupes aryle et hétéroaryle pouvant être éventuellement substitués par un groupe halogène, alkyle, alcényle et alkynyle, et dans laquelle R¿4? représente un groupe sélectionné dans l'ensemble comprenant H et alkyle.
Patent CA-2500954-C (CA)
Inventor: SCHULZE-BECKINGHAUSEN JOERG E
IPC: E21B19/06
Filed: 2005-03-16
Granted: 2010-12-14
Abstract: In one embodiment, a gripping system for a tong for making up and breaking out tubulars is provided. The gripping system is coupled to the rotary of the tong. The gripping system includes an active jaw and two passive jaws disposed interior to the rotary. Preferably, the two passive jaws are separately by less than 120 degrees from each other and are pivotally connected to rotary. The gripping system is adapted and arranged to allow each passive jaw to react the same amount of force as the gripping force applied by the active jaw. In another embodiment, a rotary locking apparatus is provided to lock or unlock the rotary of the tong.
Patent CA-2501271-C (CA)
Inventor: SHUEY KENNETH C
IPC: G01R21/133
Filed: 2005-03-17
Granted: 2014-01-14
Abstract: The invention contemplates an electrical power meter and method of operating the electrical power meter. The inventive power meter includes a power supply for converting alternating current (AC) voltage to a direct current (DC) voltage for powering the electronic components, and an optical diode in series with the power supply. The meter may also include an optical communications port in communication with the optical diode and/or a switch (e.g., a transistor) in communication with the optical diode. The switch may be in parallel with the optical diode, and allow DC current to bypass the optical diode when a request for communication is received by the meter. The DC current provided to the optical diode represents communication of data with an optical communications port. The switch may be controlled by a microprocessor device.
Patent CA-2501389-C (CA)
Inventor: IZUMIMOTO NAOKI
IPC: A61P13/00
Filed: 2003-10-08
Granted: 2013-01-08
Abstract: The invention provides a morphinan derivative of the Formula (I): (see formula I) [wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y and Z are valence bonds, -C(=O)- or the like; X is C2-C5 carbon chain (one of the carbon atoms may be substituted by oxygen, sulfur or nitrogen) constituting a part of the ring structure, or the like; (R4)k is substituted or non-substituted benzene fused ring, carbonyl group or the like; R9 is hydrogen or the like; R10 and R11 are bound to represent -O-, or the like, and R6 is hydrogen or the like] or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a therapeutic or prophylactic agent for frequent urination or urinary incontinence, comprising as an effective ingredient the morphinan derivative or the pharmaceutically acceptable acid addition salt thereof; a method for therapy or prophylaxis of the diseases, and use for the diseases. The compounds of the invention are useful as a new therapeutic or prophylactic agent for frequent urination or urinary incontinence, free from side effects, and useful for the method for therapy or prophylaxis of the diseases and for use for the diseases.
Patent CA-2501554-C (CA)
Inventor: BRIGHTON CARL T
IPC: C12N5/077
Filed: 2003-10-07
Granted: 2014-08-05
Abstract: Methods and devices for the regulation of type II collagen gene expression in cartilage cells via the application of specific and selective fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate specific and selective fields optimized for type II collagen gene expression and exposing cartilage tissue to the specific and selective fields generated by specific and selective signals so as to regulate type II collagen gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, and cartilage defects.
Patent CA-2504306-C (CA)
Inventor: DAVIES OLIVER WILLIAM HARDWICKE
IPC: H05K1/00
Filed: 2003-10-30
Granted: 2012-07-31
Abstract: La présente invention concerne un procédé et un appareil destinés à la fabrication d'une sonde électrochimique. A cet effet, on fait passer une bande de substrat par un ou plusieurs postes d'impression, on imprime une ou plusieurs électrodes sur le substrat au niveau d'un ou de plusieurs postes d'impression, puis on raccorde à l'extrémité du premier rouleau un deuxième rouleau de matériau de substrat, et on fait passer par les postes d'impression considérés le substrat ainsi raccordé.
Patent CA-2505896-C (CA)
Inventor: RAVI KRISHNA M
IPC: E21B33/138
Filed: 2003-10-24
Granted: 2008-06-03
Abstract: The current invention provides a method for enhancing the formation stability of water sensitive, reactive formations penetrated by a wellbore. The method of the current invention provides an accurate evaluation of the impact of cementing fluids on water sensitive, reactive formations and provides the ability to accurately formulate cementing fluids in order to enhance the stability of such formations. When necessary, the method of the current invention additionally provides for the application of an osmotic semi-permeable membrane to the face of the formation.
Patent CA-2507549-C (CA)
Inventor: KAGAN MICHAEL
IPC: B01L3/00
Filed: 2003-11-20
Granted: 2011-07-12
Abstract: An improved cartridge (21) has a test chamber and an overflow vestibule. The handle portion has flared grips (37, 38) and a trough to prevent adhesive form entering the analysis region. A stopper made from a single elastomer seals the test chamber and vestibule, and has a locking mechanism that mates with keepers in the handle. An improved method for filling the cartridge provides even distribution of magnetic particles.
Patent CA-2508553-C (CA)
Title: Particulate suspensions
Inventor: HEMING ALEXANDER MARK
IPC: A01N25/00
Filed: 2003-12-05
Granted: 2012-02-07
Abstract: The stability of a particulate suspension comprising an aqueous phase containing substantially no miscible organic solvent having suspended therein an agrochemical solid substantially insoluble in said aqueous phase is enhanced by (i) forming a polymeric stabiliser having a hydrophilic moiety and a hydrophobic moiety by polymerising a plurality of vinylic monomers, not being exclusively vinylic esters or their hydrolysed products, at least some of which contain functional groups capable of undergoing cross-linking reactions and (ii) reacting said polymeric stabiliser with one or more substances contained (dissolved or suspended) in the aqueous phase capable of undergoing a cross-linking reaction with said functional groups, wherein the ratio by weight of (a) the polymeric stabiliser prior to cross-linking to (b) the suspended agrochemical is less than 1 part of polymeric stabiliser per 5 parts of suspended agrochemical.
Patent CA-2509544-C (CA)
Inventor: PEARCE GRAHAM N
IPC: H04W4/02
Filed: 2003-02-07
Granted: 2010-09-28
Abstract: Procédés et appareils permettant l'application de restrictions sur des appels longue distance émis à partir de dispositifs de communication sans fil et fonctionnant dans un réseau de communication sans fil. Les appareils sans fil sont de préférence des dispositifs de communication combinés voix et données. Dans un exemple illustratif, chaque dispositif sans fil reçoit et met en mémoire des informations de restriction sur des appels longue distance qui sont introduites à partir d'un réseau informatique privé via le réseau sans fil. Lors d'un fonctionnement typique, un dispositif sans fil détermine si des essais d'appel à partir du dispositif sans fil sont soumis à restriction selon les informations de restriction sur les appels longue distance. Si un essai d'appel est soumis à restriction selon les informations de restriction sur les appels longue distance, le dispositif sans fil applique la restriction à l'essai d'appel à partir dudit dispositif sans fil et fournit un avertissement de restriction d'appel (par ex. avertissement sonore ou texte visuel). Si un essai d'appel n'est pas soumis à restriction selon les informations de restriction sur appels longue distance, le dispositif sans fil permet l'essai d'appel à partir dudit dispositif sans fil. Avantageusement, le contrôle sur les appels longue distance peut être établi sur la base des utilisateurs individuels dans le réseau informatique privé domestique.
Patent CA-2509679-C (CA)
Inventor: SIGGELKOW BETTINA
IPC: C10L1/14
Filed: 2005-06-10
Granted: 2013-07-16
Abstract: The invention provides a composition comprising A) Solvent Naphtha having a naphthalene content of less than 1% by weight, B) a middle distillate cold flow improver and C) a solubilizing additive selected from aliphatic or alicyclic C1- to C22- alcohols, cycloaliphatic hydrocarbons and monocyclic aromatic hydrocarbons.
Patent CA-2513251-C (CA)
Title: Sensibilisant d'une therapie de cancer
Inventor: TAI ISABELLA T
IPC: C12Q1/68
Filed: 2004-01-14
Granted: 2013-03-19
Abstract: La présente invention concerne des compositions et des méthodes permettant de rendre sensible une thérapie de cancer. Cette invention a trait à ces compositions contenant un polypeptide ou un polynucléotide de la famille SPARC, ainsi qu'à des cellules recombinantes renfermant un polypeptide ou un polynucléotide de la famille SPARC. Lesdites compositions et méthodes sont utilisées dans une étude in vitro de résistance d'une thérapie de cancer, ainsi que dans une thérapie de cancer ex vivo et in vivo.
Patent CA-2513868-C (CA)
Inventor: HODGES ALASTAIR MCINDOE
IPC: G01N27/26
Filed: 2004-01-16
Granted: 2015-09-29
Abstract: There is disclosed a method of measuring formation of a barrier to restrict or reduce movement of an electroactive species. The method comprises providing an electrochemical cell (1, 2, 3)having a working electrode (23, 24) and a counter electrode (23, 24) spaced from the working electrode, providing a subject component, a testing component and at least one electroactive species within the cell, the subject and testing components being intended to cause the formation of a barrier to restrict or reduce movement of an electroactive species, applying a potential between the working electrode and the counter electrode sufficient to produce a current proportional to the concentration of the electroactive species being measured, and measuring the current at the working electrode to obtain a measure of the formation of the barrier to restrict or reduce movement of the electroactive species. The electrochemical cell may be in the form of a multi-cell strip (10) with cells (1, 2, 3) formed in cut-outs in an insulating spacer layer (20) interposed between upper and lower layers (21, 22).
Patent CA-2513899-C (CA)
Inventor: LEAMON JOHN H
IPC: B01L3/00
Filed: 2004-01-28
Granted: 2013-03-26
Abstract: An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing, amplifying the prepared DNA in a representative manner, and performing multiple sequencing reaction on the amplified DNA with only one primer hybridization step.
Patent CA-2520149-C (CA)
Title: Borehole telemetry system
Inventor: HUANG SONGMING
IPC: H04H60/31
Filed: 2004-03-24
Granted: 2012-01-03
Abstract: An acoustic telemetry apparatus and method for communicating encoded digital data from a down-hole location through a borehole to the surface is described including an acoustic channel terminated at a down-hole end by a reflecting terminal (133, 134), an acoustic wave generator (140) located at the surface and providing an acoustic wave carrier signal through said acoustic, channel, a modulator (162, 163) located down-hole to modulate amplitude and/or phase of said carrier wave in response to an encoded digital signal and one or more sensors (150) located at the surface adapted to detect amplitude and/or phase related information of acoustic waves traveling within said acoustic channel to determine the encoded digital data.