Patent DE-19955349-A1 (DE)
Title: Use of novel polypeptide or its variant or nucleic acid encoding the polypeptide for diagnosing and/or preventing and/or treating skin disorders and/or treatment in wound healing or for identifying active substances
Inventor: WOLF ECKARD
IPC: A61K38/17
Filed: 1999-11-17
Abstract: Use of a polypeptide or its variant (I) or nucleic acid encoding (I) or its variant for the diagnosis and/or prevention and/or treatment of skin disorders and/or treatment in wound healing or for the identification of pharmacologically active substances. Use of a polypeptide or its variant (I) or nucleic acid encoding (I) or its variant for the diagnosis and/or prevention and/or treatment of skin disorders and/or treatment in wound healing or for the identification of pharmacologically active substances. (I) has a specific sequence and the sequence listing is not provided in the specification. Independent claims are also included for the following: (1) use of at least one nucleic acid or its variants (II) having a specific sequence, for the diagnosis and/or prevention and/or treatment of skin diseases and/or treatment in wound healing or for the identification of pharmacologically active substances, for the preparation of a vector, preferably in the form of a vector, phagemid, cosmid, expression vector or vector having gene therapy activity, or for the preparation of a knock-out gene construct or an expression cassette. Sequence listing not provided in the specification; (2) host cell (H), transformed using a vector or a knock-out gene construct comprising (II); (3) transgenic embryonic non-human stem cell (III), containing a knock-out gene construct or an expression cassette comprising (II); (4) producing a transgenic non-human mammal, involves regenerating (III) to give a transgenic non-human mammal; (5) transgenic non-human mammal, comprising in its genome, a knock-out gene construct or an expression cassette comprising (II); (6) antibody (IV) for the diagnosis and/or prevention and/or treatment of disorders in particular skin disorders, or treatment in wound healing or for the identification of pharmacologically active substances, which is directed against (I); (7) diagnostic (V) for the diagnosis of disorders in particular skin disorders and/or disorders in wound healing, containing (I), (II), (IV) together with suitable additives and auxiliaries; (8) medicament (VI) for the treatment of disorders in particular skin disorders and/or disorders in wound healing, containing (I), (II), (IV) together with suitable additives and auxiliaries; (9) test for the identification of functional interactors in connection with disorders, in particular skin disorders and/or disorders in wound healing, containing (I), (II), (IV) together with suitable additives and auxiliaries; (10) preparing an array immobilized on a support material for analysis in connection with disorders, in particular skin disorders or disorders in wound healing, involves immobilizing (I), (II), (IV) on a support material; and (11) array immobilized on a support material for analysis in connection with disorders, in particular skin disorders or disorders in wound healing, containing (I), (II) or (IV). ACTIVITY : Vulnerary; dermatalogical. No supporting data is given. MECHANISM OF ACTION : Gene therapy.