Patent SG-11201810763T-A (SG)
Title: Anti-coagulation factor xi antibodies
Inventor: CHEN ZHU
IPC: C07K16/36
Filed: 2017-06-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111113311111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/218371 Al 21 December 2017 (21.12.2017) WIP0 I PCT (51) International Patent Classification: FERT, Dietmar [US/US]; 12 Village Ct., Lawrence Town- C07K16/36 (2006.01) A61K 39/00 (2006.01) ship, New Jersey 08648 (US). (21) International Application Number: (72) Inventors; and PCT/US2017/036940 (71) Applicants (for NZ, US only): GANTI, Vaishnavi (22) International Filing Date: [IN/US]; 901 S. California Avenue, Palo Alto, California 12 June 2017 (12.06.2017) 94304 (US). TABRIZIFARD, Mohammad [US/US]; 901 S. California Avenue, Palo Alto, California 94304 (US). (25) Filing Language: English (74) Common Representative: MERCK SHARP & DOHME (26) Publication Language: English CORP.; 126 East Lincoln Avenue, Rahway, New Jersey (30) Priority Data: 07065-0907 (US). 62/349,888 14 June 2016 (14.06.2016) US (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (71) Applicant (for all designated States except US): MERCK AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, SHARP & DOHME CORP. [US/US]; 126 East Lincoln CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, Avenue, Rahway, New Jersey 07065-0907 (US). DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (72) Inventors; and HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, — (71) Applicants (for US only): CHEN, Zhu [US/US]; 5 Nor- KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, mandy Ct., Warren, New Jersey 07059 (US). ELLS- MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, WORTH, Kenneth, P. [US/US]; 2000 Galloping Hill OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, Road, Kenilworth, New Jersey 07033 (US). MILLIGAN, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, James [US/US]; 30 Lauren Lane, New Egypt, New Jersey TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = 08533 (US). OLDHAM, Elizabeth [US/US]; 901 S. Cal- (84) Designated States (unless otherwise indicated, for every ifornia Avenue, Palo Alto, California 94304 (US). SEIF- kind of regional protection available): ARIPO (BW, GH, = Title: ANTI-COAGULATION FACTOR XI ANTIBODIES (54) Intrinsic pathway = contact mAb -- activation = = .1 = FXII FX1la = Extrinsic pathway = Da FXIa Z` . 1F—FV1la = = = FIX FIXa = = r .° FV111 FXa 1-1 .4 Rivaroxaban FVa 1-1 IN apixaban Prothrombin Thrombin edoxaban en Go ,-, el Dabigatran FIG. 1A Clot IN 11 0 (57) : Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation N factor XIIa as well as activation of FIX by FXIa are described. C [Continued on next page] WO 2017/218371 Al MIDEDIMOMOIDEIRMEM00111fillifiliNEVOIMIE GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(U)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))