baber/WOPTO huggingface dataset:
Patent IL-111036-A0 (IL)
Title: Beta_alanine derivatives, processes for the preparon thereof and pharmaceutical compositions containing the same
IPC: C07D211/56
Filed: 1994-09-22
Abstract: This invention relates to  beta -alanine derivatives represented by the following formula : <CHEM> wherein each symbol is as defined in the specification and pharmaceutically acceptable salt thereof which is glycoprotein IIb/IIIa antagonist, inhibitor of blood platelets aggregation and inhibitor of the binding of fibrinogen to blood platelets, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.
Patent IL-124725-A0 (IL)
Title: A centrifuge apparatus
IPC: B01D21/26
Filed: 1996-12-06
Abstract: An apparatus for centrifuging and furthermore automatically handling a container (10) for separating a component, such as fibrin monomer, from plasma, where the container (10) comprises a cylindrical member (11) with a lower rim as well as a piston member (12) with a tubular piston rod (12) projecting upwardly from the upper end of the cylindrical member (11). The apparatus comprises a supporting turntable (1) with a first gripping member (27) releasably gripping the lower rim of the cylindrical member (11) when the container is placed thereon, the supporting turntable being connected to a first activator (5) for rotating the turntable (1) with the container (10) about the central axis thereof. Furthermore, the apparatus comprises a rotatably journalled piston activating mechanism adapted to activate the piston (12) by way of a second activator (21) and provided with a second gripping member (13) for releasably gripping the piston rod (12). The first gripping member (27) is adapted to automatically enter a locking engagement with the inner side of the cylindrical member (11) independent of the rotating position of the container (10) relative to the supporting turntable (1) and upon activation of a third activator (8) when the container (10) is placed on the supporting turntable (1). The second gripping member (13) is adapted to succeedingly and automatically enter a locking engagement with the piston rod (12) upon activation of a fourth activator (15).
Patent IL-127154-A0 (IL)
Title: Pharmaceutical compositions containing cyclosporine and a carrier comprising at least an ester of alpha-glycerophoshoric acid
IPC: A61P37/00
Filed: 1997-05-20
Abstract: A description is given of new pharmaceutical compositions containing cyclosporine, combined with a carrier comprising at least a derivative of alpha-glycerophosphoric acid, such as alpha-glycerophosphorylcholine, alpha-glycerophosphorylserine, alpha-glycerophosphorylethanolamine and alpha-glycerophosphoryl-myo-inositol, which allow cyclosporine bioavailability to significantly increase.
Patent IL-133131-A0 (IL)
Title: Apparatus for binding thread running through button sewed on garment
IPC: A41H37/00
Filed: 1998-05-30
Abstract: An apparatus for binding a button-fixing thread running through a button sewed on a garment or other fabric, which is capable of winding a binding thread around the button-fixing thread by several turns in a safe, simple, easy and convenient manner while forming a twist with the binding thread at every turn, thereby not only preventing the button from being separated due to a loosening of the button-fixing thread during a strong washing operation or an operation of passing the button through a button slit formed in the garment, but also achieving an improvement in the binding operation and an improvement in the reliability in use. The apparatus includes a thread hooking plate adapted to hook a binding thread to be wound around a button-fixing thread, a twisting member adapted to twist the binding thread hooked by the thread hooking plate and to separate the twisted binding thread from the thread hooking plate after the thread hooking plate rotates by a predetermined angle, and a twist forming member fixedly mounted to an end of the second actuating shaft disposed in the vicinity of the twisting member, the twist forming member adapted to hook the binding thread twisted by the twisting member after the twisting member rotates by a predetermined angle, thereby forming a complete twist with the binding thread.
Patent IL-138271-A0 (IL)
Title: Superabrasive wire saw and method for making the saw
IPC: B24D3/00
Filed: 1999-03-02
Abstract: A wire saw in which the blade is a metal wire having superabrasive grains bonded to the wire by metal braze or solder. An independent claim is also included for a process for making a wire saw in which a wire is coated with metal braze or solder and heated to bond the abrasive to the wire.
Patent IL-143243-A0 (IL)
Title: A cultured tissue construct containing fibroblast cells and methods for the production thereof
IPC: A61K35/22
Filed: 1999-11-19
Abstract: Cultured tissue constructs comprising cultured cells and endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. Some tissue constructs of the invention are comprised of multiple cell layers or more than one cell type. The tissue constructs of the invention have morphological features and functions similar to tissues and their strength makes them easily handleable. Preferred cultured tissue constructs of the invention are prepared in defined media, that is, without the addition of chemically undefined components.
Patent IL-161308-A0 (IL)
Title: Alkyl ether derivatives or their salts
IPC: A61P25/02
Filed: 2002-10-18
Abstract: Alkyl ether derivatives (I) are new. Alkyl ether derivatives of formula (I) and their salts are new. [Image] R 1, R 2 : H, halo, optionally substituted alkyl, aryl, aralkyl, alkoxy, aryloxy, alkylthio, arylthio, alkenyl, alkenyloxy, alkylsulfonyl, arylsulfonyl, carbamoyl, heterocyclyl, NO 2, oxo or optionally protected hydroxy, amino or carboxyl; R 3 : optionally substituted alkylamino or optionally protected amino or hydroxy; A : 5 or 6 membered heteroaryl or benzene; m, n : 1-6; and p : 1-3. ACTIVITY : Calcium-Antagonist. MECHANISM OF ACTION : Neuroprotective; CNS-Gen. In nerve regeneration models in SD rats 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol (Ia) hydrochloric acid salt administered at 1 mg/kg/day orally for 13 days increased regeneration by 186% compared to a control.
Patent IL-177946-A0 (IL)
Title: Sns-595 and methods of using the same
IPC: A61K31/44
Filed: 2006-09-07
Abstract: The invention provides a compound for use in a method for treating a solid tumor in a patient, wherein the compound is (+)-1,4- dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid and the method comprises administering the compound to the patient in a dose of 10 mg/m 2  to 100 mg/m 2 .
Patent IL-185805-A0 (IL)
Title: Substituted, bicyclic 8-pyrrolidino-benzimidazoles, method for their production and their use as medicaments
Filed: 2007-09-06
Abstract: The present invention relates to carboxamide derivative compounds of formula I in which R1-R6 and R12 are hereinafter defined and together comprise carboximide derivatives for the therapeutic treatment of diabetes, hyperglycemia, lipid and carbohydrate metabolism disorders, arteriosclerotic manifestations and disorders and other blood sugar related disorders through a metabolic blood sugar-lowering action.
Patent IL-190398-A0 (IL)
Title: Imidazo benzodiazepine derivatives
Filed: 2008-03-24
Abstract: The present invention is concerned with substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives of the following formula wherein the definition of substituents is described in the claims. This class of compounds shows high affinity and selectivity for GABA A alpha5 receptor binding sites and might be useful as a cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
Patent IL-190796-A0 (IL)
Title: Compositions and their uses for gene therapy of bone conditions
Filed: 2008-04-10
Abstract: In certain preferred embodiments, the present invention provides compositions and methods for the treatment of bone conditions associated with low bone density. In preferred embodiments, the present invention provides compositions and methods for the treatment of osteoprotegerin-responsive conditions.
Patent IL-205388-A0 (IL)
Title: Capture compounds for assessing interactions of a molecule with targets and non - targets
IPC: C07C69/96
Filed: 2010-04-28
Abstract: A capture compound and a method of identifying drug target non-target proteins in a mixture of proteins is provided, comprising the steps of interacting the mixture with a capture compound of the formula Q-Z-( Xm)-Yn, wherein Z is a trivalent moiety for presenting X, Y and Q; moiety X is selected to covalently bind to proteins; moiety Y is a pharmaceutical drug, drug fragment, drug metabolite, prodrug, enzyme substrate, enzyme inhibitor, transition-state analogue or a ligand to a receptor; Q is a sorting function selected to permit physical arraying or other addressable separation method suitable for analysis, Q comprises a biotin moiety, a (His) 6  moiety, a BODIPY moiety (4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene), an oligonucleotide or PNA (peptide nucleic acid), an antibody, an immunotoxin conjugate, an adhesive peptide, a lectin, an activated dextran or a peptide; and analyzing the captured proteins to identify drug target or drug non-target.
Patent RO-131174-A0 (RO)
Title: Autonomous thermo-vibro-insulating modular system for critical equipments and products
Inventor: SAS VIOREL NICOLAE
IPC: H05K5/00
Filed: 2015-10-28
Abstract: The invention relates to an autonomous modular system for protecting critical computerized systems and providing the optimal operating conditions thereto. According to the invention, the system comprises a box having a body (1) provided with a removable front cover (2) and a removable back cover (3) and having mounted inside, by means of some shock absorbers (5), a shielded rack (4) which accommodates electronic equipment (EE), where the rack (4) consists of a bearing structure (16) provided with some supports (17) for the shock absorbers and achieves the electromagnetic tightness by closing with some lateral panels (18), a front panel (25) and a back panel (19), closed with some latches (6, 7, 8), on the mentioned panels there being mounted some wave filters (20, 21, 26), some power supply filters (22), some filters (23) for data connections and some waveguides (24).
Patent ZM-6086-A1 (ZM)
Title: Interconnecting of low energy fuses
IPC: F42D1/06
Filed: 1986-06-23
Abstract: A connector 100 for interconnecting two lengths of low energy fuse 108, 110 includes connecting means 101 having a needle-like portion 102. The needle-like portion 102 is pointed at both ends 104, 106 to facilitate the penetration of the ends 104, 106 into the lengths of fuse 108 and 110 respectively. The connector 100 further includes a body 112 which defines seats 114 on which regions of the lengths of fuse 108, 110 can seat to be retained in position relative to the connecting means 101. End caps 116 are provided to clip into the body 112 to retain the lengths of fuse 108, 110 on the seats 114.
Patent IE-900761-A1 (IE)
Title: Installation gauge for weather seals
Inventor: ALLPORT BRIAN CHRISTOPHER
IPC: B25H7/00
Filed: 1990-03-02
Abstract: An installation gauge for door weather seals comprises a flat plate 10 having a straight edge 11 and a plurality of holes 12, 13 in the plate each at a different predetermined distance from the straight edge. The plate 10 has a further edge 16 at right angles to the straight edge, and the further edge has a plurality of grooves 17, 18 therein each associated with a respective hole, each groove and the respective hole lying on a line parallel to the straight edge.
Patent LU-88021-A1 (LU)
Inventor: VELZEN DANIEL VAN
IPC: C01B21/14
Filed: 1991-10-21
Abstract: PCT No. PCT/EP92/02381 Sec. 371 Date Apr. 21, 1994 Sec. 102(e) Date Apr. 21, 1994 PCT Filed Oct. 15, 1992 PCT Pub. No. WO93/08121 PCT Pub. Date Apr. 29, 1993.A process and device are disclosed for preparing hydroxylamine from NOx-containing flue gases. Nitrogen removal from the NOx-containing flue gases by absorption in an aqueous solution of FeII-EDTA and by desorption through vapor stripping of the NA from the thus obtained FeII(NO)-EDTA solution, with admixture of hydrogen, leading to the recovery of an NO/H2 gaseous mixture, is combined with hydroxylamine synthesis by catalytic reduction of NO with hydrogen.
Patent MA-38011-A1 (MA)
Title: Dérivés d'éthynyle comme modulateurs de l'activité du récepteur mglur5
Inventor: STADLER HEINZ
IPC: C07D213/81
Filed: 2013-10-15
Abstract: La présente invention concerne des dérivés d'éthynyle de formule (i) ou leur sel d'addition aux acides pharmaceutiquement acceptables, leur mélange racémique, ou leur énantiomère et/ou isomère optique et/ou stéréoisomère correspondant. Il a été découvert avec surprise que les composés de formule générale (i) sont des antagonistes des récepteurs métabotropes au glutamate (modulateurs allostériques négatifs) destinés à être utilisés dans le traitement de l'anxiété et de la douleur, de la dépression, du syndrome de l'x fragile, des troubles du spectre autistique, de la maladie de parkinson et de la maladie du reflux gastroœsophagien.
Patent MA-38213-A1 (MA)
Title: Dispositif pour la fabrication du miel en section
Inventor: BEN TOUNSI MOSTAFA
IPC: A01K47/04
Filed: 2015-06-18
Abstract: La présente invention concerne un dispositif pour la production du miel en section comprenant un cadres fabriqués en plastique transparent à usage alimentaire. Ce cadre étant sous forme d'un cercle à l’intérieur d'un carré ayant les angles chanfreinés. Pour produire du miel, une feuille épaisse de la cire de fondation est disposée entre deux cadres, ensuite l'ensemble est fermé par des éléments d'assemblage au niveau des angles des cadres. Une pluralité de ces cadres sont placés dans une caisse de ruche pour que les abeilles commencent à garnir la cire de fondation et la remplir du miel. Après avoir sceller le rayon du miel, les deux cadres sont emballés par des couvercles en plastique transparent pour que l'ensemble soit présentable et prêt à être commercialisé.
Patent MA-42870-A1 (MA)
Title: Formulation à base des dérivés de chromones pour tuer les bactéries résistantes aux antibiotiques
Inventor: KERBAL ABDELALI
IPC: C07D311/00
Filed: 2018-07-13
Abstract: Différentes chromones substituées sont utilisées individuellement ou en combinaison comme formulation antimicrobienne pour combattre les bactéries - résistantes et non résistantes aux antibiotiques - provoquant des infections chez les humains et chez les animaux. Plus particulièrement, les systèmes décrits dans ce brevet incluent des méthodes de traitement d'un sujet infecté par une bactérie antibiorésistante.
Patent MA-50310-A1 (MA)
Title: Système automatique de désinfection des claviers à usage collectif
Inventor: BEKRAOUI NASR
IPC: B08B3/00
Filed: 2020-07-15
Abstract: Le produit s'installe sur les claviers à usage collectifs (tel que les claviers de guichets automatiques, les boutons d'appel et de cabine d'ascenseurs, les interphones...) il a pour objet de réduire le risque de contamination au coronavirus par touché. Une fois installé, les doigts du client lors de l'utilisation du clavier sont en contact avec un film en polyéthylène transparent désinfecté qui se trouve à quelque millimètre au-dessus du clavier. La désinfection est effectuée par le passage du film plastique dans un bain de gel hydroalcoolique et un frottement contre des brosses..
Patent MA-53689-A1 (MA)
Title: Anticorps humanisés contre un fragment bêta d'une chaîne de la famille 9 du récepteur cellulaire trbv-9 de l'humain et méthodes de leur application
Inventor: NEMANKIN TIMOFEY ALEKSANDROVICH
IPC: C12N5/10
Filed: 2020-02-20
Abstract: L'invention concerne un anticorps monoclonal humanisé ou son fragment de liaison d'antigène qui se lient spécifiquement à la famille trbv-9 des récepteurs cellulaires t de l'humain. L'invention concerne également un acide nucléique codant pour cet anticorps ou un fragment de liaison à un antigène de celui-ci, un vecteur d'expression, un procédé de production d'un anticorps et l'utilisation d'un anticorps pour traiter des maladies ou des troubles associés à la famille des récepteurs des lymphocytes t humains. L'invention vise notamment la création d'anticorps qui peuvent être utilisés pour la thérapie, notamment lors d'une spondylarthrite ankylosante (sa ou maladie de bechterew), de la la maladie cœliaque et des maladies sanguines malignes dont la pathogenèse est liée à l'implication du récepteur des cellules t trbv9.
Patent UY-23905-A1 (UY)
Title: Circuito híbrido universal de línea
Inventor: JOSÉ ANTONIO POZAS ALVAREZ
IPC: H04M7/12
Filed: 1995-02-10
Abstract: El circuito híbirdo universal de línea consiste en un circuito formado por un puente de alimentación encargado de dotar a la línea de la tensión adecuada y un codificador/descodificador que realiza la conversión de señales y la programación de las unidades que componen el circuito, realizando el proceso de señalización para una línea de abonado o de enlace, pudiendo configurarse como un circuito terminal de línea descolgando la línea para iniciar determinados procesos de señalización.
Patent ES-263632-A1 (ES)
Title: Process for the production of new steroid compounds
IPC: C07J61/00
Filed: 1960-12-28
Abstract: The invention comprises 13b -alkyl homologues of pharmacologically active 18-nor estradiol compounds of the natural series, the alkyl group containing at least two carbon atoms, particularly 3, 17b -dihydroxy-13b -n-propyl-18-norestra-1, 3, 5(10)-triene and its 17-benzoate, together with a synthesis of these compounds from a 4, 5-secogon-9-ene-3, 5-dione of the formula:- <FORM:0979891/C1/1> by cyclization in alkaline media, isomerization by heating of the resulting 17b -acyloxy-13b -alkyl-gona-4, 9-dien-3-one to the corresponding 17b -acyloxy-13b -alkyl-3-hydroxy-18-nor estra- 1, 3, 5(10)-triene, saponification and, if desired, subsequent esterification or etherification. The intermediate 4, 5-secogon-9-ene-3, 5-dione is in turn prepared from 6-methoxy-3, 4-dihydronaphthyl-[2, 1-d]-isoxazole by reaction with an alkyl halide, condensation of the resulting 2-alkyl-2-cyano-6-methoxy-tetralone-1 with dimethyl succinate to form the corresponding 13b -alkyl-5-methoxy- 15 - methoxycarbonyl - des: A-gona-5, 7, 9, 14-tetraene-17-one, reaction of the latter with an alkali metal mixed hydride to effect simultaneous reduction and saponification to form a racemate of 13b -alkyl-5-methoxy-17b -hydroxy-des: A-gona-5, 7, 9, 14-tetraen-15-carboxylic acid, resolution of the racemate and removal of the carbonyl substituent from the separated laevo-rotatory enanteomorph by means of mineral acid to form the corresponding 13b -alkyl-17b -hydroxy-5-methoxy-des: A-gona-5, 7, 9, 14-tetraene, reduction of the 14-double bond by catalytic hydrogenation followed by reaction with an alkali metal in liquid ammonia to form a 13b -alkyl-17b -hydroxy-des: A-gon-9-en-5-one, esterification of the latter at C17 and reaction with pyrrolidine to form 5-pyrrolidyl-17b -acyloxy-des: A-gona-5(10), 9(11)-diene, followed by condensation with a 1, 3-dihalogeno-2-butene to form the corresponding 17b -acyloxy-13b -alkyl-3-halogeno-4, 5-secogona-2, 9-dien-5-one, which upon acid hydrolysis yields the desired intermediate. The complete synthesis is illustrated by a detailed example. The novel compounds exhibit a powerfyl estrogenic action. Specifications 914,732, 979,892, 979,895, 979,896, 979,897 and 979,898 are referred to.
Patent ES-264826-A1 (ES)
Title: Pivaloyl and undecanoyl esters of griseofulvol
IPC: C07D307/94
Filed: 1961-02-11
Abstract: The invention comprises compounds of the general formula:- <FORM:0914502/IV (b)/1> wherein R1, R2 and R3 represent alkoxy groups containing up to four carbon atoms, and esters thereof, particularly alkanoyl, aralkanoyl, aryloxyalkanoyl, alkenoyl or aroyl esters, and a process for their preparation by reducing a spirocyclic diketone of the general formula:- <FORM:0914502/IV (b)/2> with an alkali metal hydride and, if desired converting the spirocyclic keto - alcohol obtained into an ester, e.g. by reaction with the appropriate acid halide or anhydride. Specified esters include acetate, propionate, butyrate, pivalate, oxalate, acrylate, undecenoate, crotonate, benzoate, p-hydroxybenzoate, phenylacetate, and phenoxyacetate. Specification 879,789 is referred to.
Patent ES-294018-A1 (ES)
Title: Flexible clad nuclear fuel element
IPC: G21C3/06
Filed: 1963-11-29
Abstract: The fuel rod 90 is formed of fuel pellets 100 encased in tube 98 which is provided with fins, or folds, 114. The tube 98 is sealed by plugs 102, 104 and includes the space 110 which permits expansion of the fuel and retains the fission gases. The spring 112 supports tube 98 against external pressure. Rods 90 are arranged as an assembly in channel 80 through which coolant may flow from openings 88 to outlet 86. The fuel surface may be corrugated and the tube shaped to fit.
Patent ES-334217-A1 (ES)
Title: A method of and apparatus for converting nuclear energy into mechanical energy
IPC: G21C15/02
Filed: 1966-12-06
Abstract: Apparatus for converting nuclear energy into mechanical energy comprises a reactor through channels in which steam or gas is caused to flow, at least a part of which channels is rotatably arranged, and a number of these rotatably arranged channels or parts of channels are made totally or partly of nuclear fuel. The stationary parts of the channels may also be made totally or partly of nuclear fuel. Such a reactor is shown in Fig. 3 and comprises a radial flow turbine of double-rotation type, the rotor 19 and the stator 20 both being rotatable and being supported respectively by shafts 21, 22 passing through the reactor housing 23. Both the rotor 19 and the stator 20 are provided with a number of vanes 28, 29 which mesh together in such a way that each constitutes guide vanes for the other. The vanes and possibly also other parts of the rotor and stator and of the housing 23 are made to a greater or smaller extent of nuclear fuel which may be provided with a shell of a material, e.g. titanium or beryllium. The steam or gas, e.g. D 2 O steam, is supplied through feed-channels in the shafts 21, 22, flows radially outwards through the channels formed by the vanes 28, 29 and is discharged through an outlet 30 in the housing 23. The rotor 19 on the shaft 21 is axially displaceable by means of a motor 31 and motion transmitting means 32 in such a way that the vanes 28, 29 can be brought, either totally or partially, out of mesh with each other to provide reactor control. The stator 20 may be axially displaceable in a similar manner. Besides the fuel contained in the turbine, the reactor may also include fuel elements arranged in the usual manner. The shafts 21, 22 are each mechanically coupled with a compressor and an electric generator. Fluid from the outlet 30 is fed via a heat exchanger to the two compressors before being returned to the feed-channels in the shafts 21, 22.