baber/WOPTO huggingface dataset:
Patent CZ-293687-B6 (CZ)
Title: Purification process for the preparation of extremely pure cyclosporin A and the extremely pure cyclosporin A prepared in such a manner
Inventor: KERI VILMOS
IPC: C07K1/16
Filed: 1998-03-23
Abstract: In the present invention, there is disclosed a process for the chromatographic purification of cyclosporin A from a crude product containing cyclosporin mixture by making use of a column filled with silica gel and by the application of multistep chromatography with a column filled with normal phase silica gel and being present in a mixture of solvents containing toluene as the major component. Claimed is also an extremely pure cyclosporin A prepared in the above-described manner.
Patent SK-279539-B6 (SK)
Title: Plastic support for a heart valve prosthesis
Inventor: RELIGA ZBIGNIEW
IPC: A61F2/24
Filed: 1992-05-08
Abstract: A support has, at one of its axial ends, axially projecting support arms (4) which are distributed over the circumference and are rounded at the free end. The support is further provided with axial depressions (6) being opposite to the free end of the arms (4) in between which, projections (5) are arranged. The support has also a covering for fastening biological material of the valve and is made as a single piece, and consists of flat, closed material-which itself has an approximately hollow cylindrical or hollow conical shape and is provided with a strengthened annular region (11). At the annular region (11) and therewith, the wall of the support (1a) is narrowing towards the free ends of the supports (4) and projections (5).
Patent SK-280759-B6 (SK)
Title: Dowel for prestressed concrete sleepers
Inventor: HORN PETER
IPC: F16B13/00
Filed: 1992-05-15
Abstract: A dowel (1) for prestressed concrete sleepers is extended by a frustoconical cap (4) on the end (3) of the internal thread that is provided in cylindrical body (6). The frustoconical cap (4) is provided with a bottom (5).
Patent SK-279306-B6 (SK)
Title: Break double-pedal with mechanical control of break valve
Inventor: URBANEK HENRICH
IPC: B60T11/20
Filed: 1990-03-29
Abstract: A break double-pedal with a mechanical control of the break valve (11), with two independent pedals (7) has a journal (1) of the pedals (7) whereof both its ends are mounted to slidings (2). The slidings (2) are embedded, movably, in oval grooves (3) formed in console (5) arms (4) of the pedals (7). In between the pedal (7) bosses (6), there is a ball bearing (42) with a connecting strut (9) mounted on the journal (1) of the pedals (7). The connecting strut (9) is connected with an operating rod (10) of the break valve (11) by means of a rocker arm (20), two-arm lever (30) and a length-adjustable rod (33).
Patent SK-281825-B6 (SK)
Title: Peptide and method of obtaining it
Inventor: DEIGIN VLADISLAV ISAKOVICH
IPC: A61K38/08
Filed: 1996-05-06
Abstract: The invention pertains to medicine, specifically to methods of obtaining biologically active substances with immunoregulatory properties, and can be used in medicine, veterinary science and experimental biochemistry. The problem addressed by the invention is that of producing a novel synthetic biologically active peptide with immunoregulatory properties of formula X-A-D-Trp-Y, in which A is D-Glu, iD-Glu; X is H or Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp,  gamma -aminobutyric acid,  xi -aminocaproic acid; Y is Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp,  gamma -aminobutyric acid, xi -aminocaproic acid, -OH or substituted amide (C1-C3). The method of producing the peptide involves the synthesis of glutamil-containing peptides in solution by scission of an internal anhydride of tributyloxycarbonyl glutamic (D or L) acid with the appropriate k-salt of D-Trp-Y. This is followed by chromatographic separation of  alpha - and  gamma -isomers. Further synthesis was carried out by building up a peptide chain using activated esters of tributyloxycarbonyl amino acids.
Patent SK-282146-B6 (SK)
Title: Cyclic aminophenylacetic acid derivatives, method and intermediates for their production and pharmaceutical preparations based on them
Inventor: KOHNOI YASUSHI
IPC: C07C317/48
Filed: 1992-04-15
Abstract: A novel cyclic aminophenylacetic acid derivative which has an immune response modulatory activity, represented by general formula (1), an optical isomer thereof and salts thereof, a process for producing the same, and a remedy for autoimmune diseases containing the same as an active ingredient. In Formula (1), R and R<1> represent each independently hydrogen or C<5> to C<7> lower alkyl; R<2> represents trifluoromethyl or phenyl which may be substituted by one to three groups selected among halogen, methoxy and combinations thereof; and X represents hydrogen, C<5> to C<7> lower alkyl, C<5> to C<7> lower alkoxy, cyano, thiocyano, trimethylsilylethynyl, phenyl which may be substituted by one to three groups selected among halogen, methoxy, methyl and combinations thereof, carbamoyl, carboxyl, C<5> to C<7> lower alkoxycarbonyl, acetyl, benzoyl, nitro, amino, C<5> to C<7> lower alkanoylamino, benzoylamino which may be substituted, phenylsulfonylamino which may be substituted, C<5> to C<7> lower alkylthio, C<5> to C<7> lower alkylsulfinyl, C<5> to C<7> lower alkylsulfonyl or halogen. <CHEM>
Patent CZ-301571-B6 (CZ)
Title: Calibration pointer, robotic machine with calibration pointer and method of setting the robotic machine through the mediation of the calibration pointer
Inventor: FUSARO ROBERT ANTHONY
IPC: C23C4/12
Filed: 2001-02-14
Abstract: In the present invention, there is disclosed a calibration pointer (28) for a robotic machine (10) having a machine tool (18) removably supported in a mount (16) for following a programmable path (42) over a workpiece (26), a calibration pointer (28) comprising: a housing (30) configured like said tool (18) for being supported in said mount (16); and a laser (32) affixed in said housing for emitting a laser beam (34) at said workpiece (26) wherein said laser (32) has an adjustable focal length for focusing said laser beam in a focused spot at correspondingly different offsets from said housing (30). There is also disclosed the robotic machine (10) having the above-indicated pointer and including a multi-axis arm (12) supporting at a distal end thereof said machine tool (18) in the form of a plasma spray gun (18), said gun including a plasma spray nozzle (20) mounted therein. Said pointer housing (30) comprises a second plasma spray nozzle having said laser sealingly mounted therein. There is further disclosed method of setting the robotic machine using said calibration pointer (28), said method comprising: mounting said pointer (28) in said robotic machine (10; operating said machine (10) to traverse said pointer (28) along the programmable path; and projecting the laser beam (34) in a focused spot (34a) at said workpiece (26) at an offset therefrom. subsequently sequentially repositioning said arm (12) and pointer (28) mounted thereto to effect a grid path (42) over said workpiece (26) having a plurality of discrete points at which said focused spot is positioned in turn, wherein said arm (12) is repositioned by withdrawing said pointer (28) away from said workpiece (26), moving said pointer (28) laterally, and then extending said pointer (28) toward said workpiece (26) path by: analytically determining coordinates of said pointer (28) relative to said workpiece (26) at each of a grid points to effect corresponding offsets thereat; and recording said analytical coordinates in said machine.
Patent CZ-305005-B6 (CZ)
Title: Benzopiperidinyl imidazolidine derivative, processes for its preparation and pharmaceutical composition containing thereof
Inventor: VAN EMELEN KRISTOF
IPC: C07D491/06
Filed: 2001-06-13
Abstract: In the present invention, there is disclosed a benzopiperidinyl imidazolidine derivative of the general formula I, wherein the radical -ae1=ae2-ae3=ae4- comprises one or two ae1 to ae4 N atoms, -A- denotes -N(Re6)-Alke2- or a heterocycle having 1-2 nitrogen atoms; Re1, Re2 and Re3 each is independently selected from the group consisting of H, , alkyl containing 1 to 6 carbon atoms, OH or a halogen; Alke1 and Alke2 are optionally substituted by alkanediyl having 1 to 6 carbon atoms; Re5 has the formula d-1 to d-5, wherein n is 1 or 2; when pe1 is 0, pe2 is 1 or 2 and vice versa; X denotes oxygen, sulfur or =NRe9; Ye2 represents oxygen or sulfur; Re7 denotes hydrogen, alkyl containing 1 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, phenyl or phenylmethyl; Re8 denotes alkyl containing 1 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, phenyl or phenylmethyl; Re9 represents CN, alkyl containing 1 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, alkyloxycarbonyl containing 1 to 6 carbon atoms or aminocarbonyl; Re10 denotes hydrogen or , alkyl containing 1 to 6 carbon atoms or a stoichiometric isomer thereof, N-oxide, pharmaceutically acceptable acid addition salt or quaternary ammonium salt. Disclosed is also the use of the above-described derivative as a medicament, further processes for its preparation and pharmaceutical composition containing thereof. The derivative of the general formula I can be advantageously used in the treatment of disturbed fundic accommodation.
Patent CZ-294867-B6 (CZ)
Title: Bacterial plasmid, DNA sequence and use thereof
Inventor: HACKER JORG
IPC: A23L33/00
Filed: 1998-04-01
Abstract: The present invention relates to a novel bacterial plasmid pMUT2 that is usable as an expression vector, further for analytic and diagnostic purposes in microbiology or for therapeutical purposes. The invention also relates to a DNA sequence comprised in such a plasmid.
Patent CZ-300378-B6 (CZ)
Title: Stable non-aqueous formulation of a peptide compound and method for preparation thereof
Inventor: STEVENSON CYNTHIA L
IPC: A61K38/095
Filed: 1997-07-01
Abstract: The present invention relates to a stable non-aqueous polar formulation of a peptide compound comprising a) an LHRH-related compound; and b) at least one polar aprotic solvent selected from the group consisting of DMSO and DMF, wherein said formulation is stable at 37 degC for a period of at least 3 months. The formulation comprises at least 10 percent by weight of a peptide compound and advantageously at least 30 percent by weight of peptide compound. Named peptide compound is selected from a group comprising leuprolide, LHRH, nafarelin or goserelin. Method of preparing stable non-aqueous formulation comprises dissolving an LHRH-related compound in at least one polar aprotic solvent selected from the group consisting of DMSO and DMF.
Patent CZ-302518-B6 (CZ)
Title: Method of isolation and purification of montelukast
Inventor: HALAMA ALES
IPC: C07D215/18
Filed: 2007-07-09
Abstract: In the present invention, there is disclosed a method of isolation and purification of montelukast of the general formula I from reaction mixtures, said method comprising conversion of the crude substance to well-crystallizing salts with primary amines in the environment of at least one organic solvent and acetonitrile, followed by re-crystallization of these salts with simultaneous removal of chemical impurities and use of the chemically pure salts of Montelukast with primary amines for direct transformation to the pharmaceutically useful amorphous form of montelukast sodium of the general formula II.
Patent CZ-308233-B6 (CZ)
Title: A method of carrying out a compression cycle and a compressor for this
Inventor: ČERNÝ OTAKAR
IPC: F04C29/12
Filed: 2019-03-20
Abstract: In the compression cycle, the first part of compressing the intake gas in the working space (5) is carried out by supplying the compressed gas directly to the working space (5) by a different path (10) than the path (9) for the suppression if the compressed gas from the working space (5) prior to the discharge is performed exclusively polytropically with a compression ratio which varies according to the gas pressure in the discharge space, and over the entire operating range of the compressor. In the compressor, the discharge path (9) for the compressed gas from the working space (5) for this purpose is separated from the working space (5) by at least one discharge valve (16, 16e).
Patent SK-283965-B6 (SK)
Title: Christmas tree decorations consisting of several blown glass objects assembled together
Inventor: MOSTOWSKI ALEKSANDER
IPC: C03C27/10
Filed: 1998-07-16
Abstract: The invention concerns a method for producing Christmas tree decorations consisting of several blown glass objects assembled together consisting in: implanting a seat in the base element body which can freely receive the tenons of the other element. Before they are assembled the seat and the tenon are coated with a quick-setting plastic binder such that the seat-tenon assembly is slightly elastic. The unpolished Christmas tree decoration can therefore be easily subjected to further surface treatment such as being painted, coated with paste or covered with brocade and the like.
Patent CZ-297716-B6 (CZ)
Title: Windowpane unit
Inventor: KIRIAKOU WASSILIOS
IPC: B60J10/70
Filed: 1999-08-18
Abstract: The present invention relates to a windowpane unit comprising a windowpane (11, 31) and a frame (12, 32). The frame (12) consists of two parts, a basic frame (15, 35) and an additional frame (16, 36). The basic frame (15, 35) is made of elastic material as a separated shaped part. The additional frame (16, 36) is made as a separated shaped part. The basic frame (15, 35) is provided with a connecting surface (21, 41) for connecting with the additional frame (16, 36). The additional frame (16, 36) is also provided with a connecting surface ((26, 42) that is adapted to the connecting surface (21, 41) of the basic frame (15, 35). The additional frame (16, 36) is joined via its connecting surface ((26, 42) and said basic frame (15, 35) connecting surface (21, 41) removably or permanently together. The basic frame (15, 35) is provided only on its one side with a bearing surface (17, 37), which contacts the windowpane (11, 31), to which the frame is permanently fixed by means of an adhesive layer (19) deposited on the bearing surface.
Patent CZ-299227-B6 (CZ)
Title: Enteric coated pharmaceutical dosage form process for preparing and use of such dosage form as well as layered tablet or pellet for such dosage form
Inventor: LUNDBERG PER JOHAN
IPC: A61K31/444
Filed: 1998-12-17
Abstract: In the present invention, there is disclosed an enteric coated pharmaceutical extended release dosage form of an He+, Ke+-ATPase inhibitor, a layered tablet or pellet for such dosage form, process for preparing the enteric coated pharmaceutical dosage form for the preparation of a medicament intended for improving inhibition of gastric acid secretion. The invented dosage form comprises at least two portion of the He+, Ke+-ATPase inhibitor, said two portions being released in two successive pulses, The dosage form of the present invention contains at least one fraction with pulse delayed release and a second fractions of immediate release of the He+, Ke+-ATPase inhibitor. These portions are released within an interval of 0.5 up to 12 hours, preferably within an interval of 0.5 to 8 hours and most preferably within an interval of 0.5 to 4 hours wherein the invented dosage form is intended for administration once per day.
Patent CZ-298941-B6 (CZ)
Title: Pharmaceutical compositions intended for permanent release of peptides
Inventor: PELLET MARC
IPC: A61K38/00
Filed: 1999-03-22
Abstract: The present invention relates to novel solid or semisolid pharmaceutical compositions containing water-soluble and gel-forming peptide salt of great specific surface of at least 4 me2/g. The invented compositions can also include an excipient and/or water. After being injected in a patient body, the composition forms a gel and liberates the peptide salt for a long time interval of at least 15 days.
Patent CZ-294749-B6 (CZ)
Title: Supporting device for several clamping bushes
Inventor: EHMES ULRICH DR
IPC: B24B13/005
Filed: 2001-10-29
Abstract: The present invention relates to a supporting device for several clamping bushes, which device is intended for fine grinding or polishing of optical structural parts. A clamping bush is provided with a vacuum or air inlet and the supporting device has a spindle adapter (1) with a central hole (5) for supply of vacuum or air. On said spindle adapter (1) head, there are fastened in an inclination angle toward the axis (20) of the spindle adapter (1) adjustable arms (14) with inserts (16) for the clamping bush, whereby between the inserts (16) and the spindle adapter (1), there is arranged an elastic vacuum  and air line (18).
Patent CZ-298617-B6 (CZ)
Title: Device for attaching flat symmetrical cable
Inventor: HAPPLE WOLFGANG
IPC: H02G3/30
Filed: 2000-11-18
Abstract: The inventive device serves to place, with an exact angle, ribbon cables (4) on a support plate and to attach the ribbon cables thereto. The device is comprised of a cross-shaped, flat plastic part (1) with a quadrilateral center area (2) from which four projections (3a, 3b, 3c, 3d) extend opposite one another in pairs. This flat part (1) can be folded along a recess (9), which runs diagonally through the center area (2), so that each two adjacent projections (3b, 3c and 3a, 3d) overlap and can be held in this position. Means, which are arranged on the center area (2) and on at least one of the projections (3), are provided for holding a ribbon cable (4), which is inlaid over the projections (3a and 3c) as well as the center area (2). The holding means are comprised of a tab (7) which, at a small distance from the surface of the projection (3a), extends over a portion of the width thereof. The holding means are also comprised of a wedge-shaped plate (12), which rises parallel to said tab (7) over a portion of the center area (2), whereby the wedge surface (13) thereof runs parallel to the bottom edge (10) of the recess (9). After the ribbon cable (4) has been inserted under the tab (7) and the plate (12), and the adjacent projections (3b, 3c and 3a, 3d) have been folded one over the other, the ribbon cable (4) can be bent in the designated direction by means of the wedge surface (13).
Patent SK-288907-B6 (SK)
Title: Drum for winding and moulding components for production of raw tire-casings
Inventor: BAKOŠ ŠTEFAN
IPC: B29D30/32
Filed: 2017-12-13
Abstract: It comprises two basic symmetrical parts placed on a supporting hollow shaft (1), in the middle between these basic symmetrical parts there is a symmetrical central cylinder (21) forming the central part of the drum, which in the axis A1 is equipped with air supply under pressure p2 into the inner space of the central cylinder (21), for shaping the inner parts of a car tyre. Each said symmetrical part comprises a mechanism for clamping the wire beads, a mechanism (2) for the inner support of the wire beads (24.3) and a support basket (8) slidably mounted on a supporting hollow shaft (1), which comprises a pneumatic cylinder (8.2) equipped with a piston and a winding segments (10) equipped with a spring system (9) for holding in the correct position. A locking lock (8.1) in the form of a ring for blocking the movement of the wrapping levers (7) in the basic position and in the working positions of the individual stages of production of raw tyres is firmly attached to the body (8.4) of the support basket (8) by resting the ring on the outside of the wrapping levers ( 7) by supplying a suitable ratio of air pressures p2 and p3 in the pneumatic cylinder (8.2).
Patent AT-501145-B8 (AT)
Inventor: BRAUNBOECK ANDREAS
IPC: A47C4/54
Filed: 2005-01-13
Granted: 2007-02-15
Abstract: The inflatable furniture (1) has a rigid base plate (2) and a rigid cover plate (3). A hollow body (4), loaded with high pressure, is arranged between the base plate and the cover plate. The hollow body supports the cover plate at the base plate. A lateral surface (9) has a polygonal cross section with two running edges between the base plate and the cover plate. The reinforcement elements are provided in the area of the edges.
Patent EP-1528084-B8 (EP)
Inventor: SCHMIDT MARTIN U DR
IPC: C09D5/03
Filed: 2001-06-21
Granted: 2008-08-27
Abstract: Phase transformation of C.I. Pigment Yellow 191 involves the effect on it, its tautomers, cis-trans isomers or cis-trans isomer tautomers of diethylene glycol dimethyl ether. Phase transformation of C.I. Pigment Yellow 191 of formula (I) involves the effect on it, its tautomers, cis-trans isomers or cis-trans isomer tautomers of diethylene glycol dimethyl ether. [Image] An independent claim is produced for the gamma modification of (I) or its isomers or tautomers, this modification optionally containing sodium or chloride ions or water molecules in its crystal lattice and having an X-ray powder diffractogram with characteristic lines. Gamma-modification is given by 2theta d/d/relative intensity values of 4.77/18.49/100; 10.08/8.67/27; 11.79/7.50/29; 13.39/6.60/20; 14.34/6.17/21; 16.71/5.30/22; 18.23/4.86/30; 21.22/4.18/29; 22.67/3.91/21;23.10/3.84/20 and 25.79/3.45/36 respectively.
Patent EP-1995986-B8 (EP)
Inventor: CORMIER JEAN-PHILIPPE
IPC: H04W28/04
Filed: 2007-06-18
Granted: 2010-05-19
Abstract: Wireless devices and methods are provided for performing mobile discovery of an active data subscription. This involves a wireless device attempting to register using an APN that is one of a CDMA-centric APN and a GSM-centric APN. If that attempt fails, then the wireless device attempts to register using an APN that is the other of the CDMA-centric APN and the GSM-centric APN. In some cases the first APN attempted is always the CDMA-centric APN; in some cases the first APN attempted is a previously successfully used APN. For wireless devices with a data roaming enable/disable mechanism, the method can be executed while data roaming is disabled such that when data roaming is enabled, the proper APN to use will have been previously identified.
Patent EP-2261759-B8 (EP)
Inventor: YASUI YUJI
IPC: F02D41/14
Filed: 2002-04-19
Granted: 2012-12-05
Abstract: A control system for a plant is provided. This control system can control the plant more stably, when the model parameters of the controlled object model which are obtained by modeling the plant, which, is a controlled object, are identified and the sliding mode control is performed using the identified model parameters. The model parameter identifier (22) calculates a model parameter vector (¸) by adding an updating vector (d¸) to a reference vector (¸ base) of the model parameter. The updating vector (d ¸) is corrected by multiplying a past value of at least one element of the updating vector by a predetermined value which is greater than "0" and less than "I". The model parameter vector (¸) is calculated by adding the corrected updating vector (d¸) to the reference vector (¸base).
Patent AU-2002352090-B8 (AU)
Title: Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors
Inventor: FOWST CAMILLA
IPC: C07D403/14
Filed: 2002-12-18
Granted: 2008-06-19
Abstract: The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-bromo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and a protein kinase (serine/threonine and tyrosine kinases) inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.