baber/WOPTO huggingface dataset:
Patent DE-60029225-T2 (DE)
Inventor: ASTATKE MEKBIB
IPC: C12Q1/686
Filed: 2000-06-30
Granted: 2007-07-05
Abstract: The present invention relates to nucleic acid inhibitors, compositions and method for enhancing synthesis of nucleic acid molecules. In a preferred aspect, the invention relates to inhibition or control of nucleic acid synthesis, sequencing or amplification. Specifically, the present invention discloses nucleic acids having affinity for polypeptides with polymerase activity for use in such synthesis, amplification or sequencing reactions. The nucleic acid inhibitors are capable of inhibiting nonspecific nucleic acid synthesis under certain conditions (e.g., at ambient temperatures). Thus, in a preferred aspect, the invention relates to "hot start" synthesis of nucleic acid molecules. Accordingly, the invention prevents, reduces or substantially reduces nonspecific nucleic acid synthesis. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the nucleic acid inhibitors or compositions of the invention. The invention also relates to using the inhibitors of the invention to prevent viral replication or treat viral infections in a subject. Thus, the invention relates to therapeutic methods and pharmaceutical compositions using the inhibitors of the invention. The invention thus may be used for    in vivo     and    in vitro     inhibition of nucleic acid synthesis and /or inhibition of polymerase acitivity.
Patent DE-60029314-T2 (DE)
Inventor: KOCHKINE ALEXEI
IPC: C07H15/18
Filed: 2000-03-24
Granted: 2007-07-12
Abstract: A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs.
Patent DE-60037598-T2 (DE)
Inventor: PURDY DESMOND
IPC: A61K47/48
Filed: 2000-11-13
Granted: 2008-12-11
Abstract: Agents are provided which are capable of inhibiting the cell division cycle in a target cell of interest. The agents comprise first and second components, wherein the first component is a targeting moiety which is capable of directing the second component to the target cell of interest. The second component is capable of inhibiting the cell division cycle in the target cell of interest. The agents are preferably provided in the form of conjugates, and the second component is preferably a cytolethal distending toxin. Methods for the preparation of the agents, and the use thereof for treating proliferative cell disorders and intracellular pathogens are also provided.
Patent DE-60100893-T2 (DE)
Inventor: PIKE E
IPC: B62D35/00
Filed: 2001-02-21
Granted: 2004-05-19
Abstract: A system and method for efficiently removing rain water and the like from a rear window (backlite) of a vehicle. A rear spoiler or air deflector is provided for redirecting air toward the backlite and causing the speed of air flow to increase. A hydrophobic coating is provided on the major exterior surface of the backlite. Air directed by the air deflector over and/or across the surface of the backlite functions to remove the rain water and the like from the backlite. In certain embodiments, the hydrophobic coating may include diamond-like carbon (DLC) deposited on the substrate in a manner to increase its hydrophobicity.
Patent DE-60101039-T2 (DE)
Inventor: KRALL P
IPC: A47J43/10
Filed: 2001-06-12
Granted: 2004-07-22
Abstract: A hand-held mixer (1) includes a drive mechanism (36) for driving mixing tools (28, 29, 30, 31, 32, 33, 34, 35), which mixing tools are detachably coupled to the drive mechanism (36) and are disengageable from the drive mechanism (36) with the aid of a movable disengaging device (42), and further includes speed switching circuits within a first module (9), with the aid of which speed switching circuits the speed of the mixing tools can be switched to different speed values. A movable actuating element (19) actuates the speed switching circuits and includes a switching handle (20). The disengaging device (42) and the actuating element (19) including the switching handle (20) are formed as a one-piece second module (44) which is arranged so as to be movable parallel to only one path of movement (43) both for actuation of the speed switching circuits and for disengagement of the mixing tools from the drive mechanism (36).
Patent DE-60104481-T2 (DE)
Inventor: DUBOIS ERIC
IPC: C07C51/02
Filed: 2001-05-22
Granted: 2005-08-18
Abstract: Producing high-purity lactic acid from an aqueous lactate salt solution, comprising treating the solution with a strong acid, evaporating the solution to crystallize salts of the strong acid, and recovering lactic acid in solution, is new.
Patent DE-60106023-T2 (DE)
Inventor: FRY JOHN
IPC: D06M23/02
Filed: 2001-07-23
Granted: 2005-02-03
Abstract: This invention relates to an ironing aid composition which is suitable for pouring directly into the water reservoir chamber of a steam iron.
Patent DE-60115220-T2 (DE)
Inventor: MAGNUSSEN BJOERN
IPC: H01L41/09
Filed: 2001-03-21
Granted: 2006-08-17
Abstract: A single piezoelectric (22) is excited at a first frequency to cause two vibration modes in a resonator (24) producing a first elliptical motion (100a) in a first direction at a selected contacting portion of the resonator that is placed in frictional engagement with a driven element (42) to move the driven element in a first direction. A second frequency excites the same piezoelectric to cause two vibration modes of the resonator producing a second preferably elliptical motion (100b) in a second direction at the selected contacting portion to move the driven element in a second direction. The piezoelectric is preloaded in compression by the resonator. Walls of the resonator are stressed past their yield point to maintain the preload. Specially shaped ends on the piezoelectric help preloading. The piezoelectric can send or receive vibratory signals through the driven element to or from sensors to determine the position of the driven element relative to the piezoelectric element or resonator. Conversely, the piezoelectric element can receive vibration or electrical signals passed through the driven element to determine the position of the driven element. The resonator is resiliently urged against the driven element, or vice versa. Plural resonators can drive common driven elements.
Patent DE-60115964-T2 (DE)
Inventor: PACCHIANA PAOLO
IPC: B29C43/08
Filed: 2001-07-27
Granted: 2006-08-24
Abstract: A mould for moulding braking bands with ventilation ducts with the use of composite material and, in particular, of C/SiC ceramic material, comprises two half-moulds with respective impression surfaces which face one another and lie perpendicular to an axis of symmetry and which, together with outer and inner cylindrical walls, define a moulding cavity in the shape of the braking band to be moulded. The mould also has pin elements which have the shape of the ventilation ducts and which can be transferred by secondary actuating means from a rest position to a working position and vice versa, the pin elements being outside the moulding cavity in the rest position and the pin elements being inserted in the moulding cavity in the working position.
Patent DE-60116708-T2 (DE)
Inventor: ARIESEN PEL
IPC: B65F1/14
Filed: 2001-06-26
Granted: 2006-08-17
Abstract: The present invention relates to a device (1) for storing waste material, comprising:   a container (2) in which waste material can be stored having on the upper side an insertion unit (3) for depositing the waste into the container; an outer casing of a pit (6) for arranging in the ground in which the container (2) can be placed in fitting manner; hoist engaging means to enable upward movement of the container (2) out of the pit (6) for the purpose of emptying thereof and to enable downward movement of the container (2) into the pit (6); a cover element (5) for covering the pit (6) in the downwardly moved situation, wherein the cover element (5) can be placed lying substantially flush with the ground or the pavement provided thereon.     <IMAGE>
Patent DE-60120475-T2 (DE)
Inventor: CURUTCHARRY JEAN
IPC: A61J1/05
Filed: 2001-12-06
Granted: 2007-01-04
Abstract: A re-forming device in particular for mixing substances in the medical field, includes a hollow needle pointed at its two tips and fixed on a support defining two coaxial sleeves enclosing each end of the needle and designed to receive, one, the plug opening of a vial, the other, the hub of an injection tube of a flexible bag, so as to communicate, by perforating the plug and hub, the vial and the flexible bag via the needle. The sleeve, on the side of the flexible bag, is dimensioned and designed to be engaged on the hub in a first stable position wherein the device is secured to the bag without the needle being in contact with the hub and the sleeve is mounted sliding on the hub so as to pass, through simple depression of the device on the hub, from the first position into a second position, corresponding to the perforation of the hub by the needle.
Patent DE-60124775-T2 (DE)
Inventor: ELEY ANN MAGARET
IPC: F04C2/00
Filed: 2001-07-09
Granted: 2007-09-13
Abstract: A stator (1) has a circular cylindrical internal surface (3) delimiting an operating chamber. A rotor (4) is mounted so as to be rotatable about the axis (8) of the internal surface (3) and has a cylindrical external surface (11), with one generatrix (13) adjacent to the internal surface (3), a diametrically opposite generatrix being spaced from the internal surface. A sealing member (17), projecting through a slot in the stator (1) into the operating chamber and being movable substantially radially, has an axial length substantially equal to that of the rotor (4). The sealing member (17) is connected to the rotor (4) by a linkage which causes the radially inner end of the sealing member to closely follow the external surface (3). A shutter disc (6) at one end of the rotor (4) covers a port (14), in particular an inlet port, in the stator (1). The disc (6) has a through-hole with a first end remote from the operating chamber and a second end opening into the operating chamber, the first end periodically overlapping the port (14) as the rotor (4) rotates.
Patent DE-60126096-T2 (DE)
Inventor: YUAN XINHONG
IPC: G06Q20/04
Filed: 2001-07-19
Granted: 2007-10-18
Abstract: A first user (110) requests a service provider (130) to create (200,400) a record of a transaction. The service provider (130) creates (230,430) a digital receipt (300,700,900), which includes a description (310,710,720,910,1020) of the transaction understandable by humans, tamper-proof evidence (320) of the transaction, and a verification prompt (330,740,940,1030). A second user (120) who desires to verify the transaction displays (265,465) the digital receipt (300,700,900) and activates (270,470) the verification prompt (330,740,940,1030). Upon activation, the tamper-proof evidence (320) is verified without requiring further human interaction to identify the tamper-proof evidence.
Patent DE-60128732-T2 (DE)
Inventor: BILLMAN TIMOTHY B
IPC: H01R13/04
Filed: 2001-03-27
Granted: 2008-01-24
Abstract: The present invention relates to an electrical connector (10') comprising paired signal and ground contacts (32, 34); additional ground contacts (34a) located between at least some of the paired contacts (32, 34); and a housing (12) having first contact receiving areas with the paired contacts (32, 34) located therein and second contact receiving areas (B1) with the additional ground contacts (34a) located therein. At least one (A) of the second contact receiving areas (B1) does not contain an additional ground contact (34a) such that two of the paired contacts (32, 34) on opposite sides of the at least one second contact receiving area form a differential pair of contacts (32D) for high speed differential pair signal transmission. <IMAGE>
Patent DE-60130780-T2 (DE)
Inventor: BENNETT SIDNEY M
IPC: G01C19/72
Filed: 2001-06-14
Granted: 2008-04-30
Abstract: A fiber optic sensor with a digital signal processing system and a method of using a digital signal processing system with a fiber optic sensor is disclosed. The system digitally samples the output signal of the fiber optic sensor at a frequency which is an integer multiple of the modulator drive frequency and multiplies the sampled output signal with predetermined sine and cosine coefficients corresponding to the (fundamental) modulator drive frequency and at most the second, third and fourth harmonic thereof. This simple system can maintain a constant modulation depth and modulator phase shift and provide sensor output data over a wide operating range of the fiber optic sensor. The fiber optic sensor can be employed, for example, for rotation rate and magnetic field measurements.
Patent DE-60133287-T2 (DE)
Inventor: ITOH KYOGO
IPC: A61K35/56
Filed: 2001-07-30
Granted: 2009-03-26
Abstract: Tumor antigen inducing and/or activating HLA-A2-restricted tumor-specific cytotoxic T lymphocytes that is activated by recognizing HLA-A2 and a tumor antigen peptide, and a peptide or polypeptide derived from the tumor antigen, a polynucleotide encoding the peptide or a complementary strand polynucleotide thereof, a transformant comprising a recombinant vector which comprises the polynucleotide are provided.
Patent DE-60203099-T2 (DE)
Inventor: VAN ACKERE MICHEL
IPC: H04L29/06
Filed: 2002-06-04
Granted: 2006-05-04
Abstract: The invention relates to providing network access to separate virtual private network. It relates to a method for proxying user authentication-authorization-and-accounting messages via a network access server (NAS) and at least two separated virtual private networks (VPNs), wherein a first VPN has it's own first authentication-authorization-and-accounting server (AAA server), and a second VPN has it's own second AAA server, comprising the steps of:  said NAS D2 invokes (2) said first AAA server D7 for a user authentication-authorization-and-accounting and when said first AAA server D7 is not responsible for the user authentication-authorization-and-accounting, said first AAA server D7 partly steers the NAS D2 operation and identifying a configuration for a responsible second AAA server D8, if this information is available and if no information is available, forcing said NAS D2 to select or identify a configuration for the responsible second AAA server D8 and said NAS D2 invokes said second AAA server D8, based on the said configuration, and this second AAA server D8 performs a real user authentication-authorization-and-accounting and a decisive steering of the NAS operation (5).  <??>Further it relates to a network access server, an authentication-authorization-and-accounting server, and computer software products for proxying user authentication-authorization-and-accounting messages via a network access server. <IMAGE>
Patent DE-60213365-T2 (DE)
Inventor: GASPARINI FABRIZIO
IPC: A61P43/00
Filed: 2002-02-06
Granted: 2007-08-09
Abstract: The invention relates to the use of mGluR5 antagonists for treating pruritic conditions.
Patent DE-60215387-T2 (DE)
Inventor: ACCHIONE JOE
IPC: H05B33/26
Filed: 2002-12-16
Granted: 2007-08-30
Abstract: The invention relates to improving the stability of the lower electrodes in an electroluminescent display employing a thick film dielectric. The invention is an encapsulated electrode comprising an electrode of an electrically conductive metallic film. A layer of encapsulating material is provided on an upper and/or lower surface of the electrode layer. The encapsulating material reduces the risk of the electrode from becoming discontinuous and losing its electrical conductivity.
Patent DE-60219270-T2 (DE)
Inventor: BONNEFOUS JEAN
IPC: F16H55/14
Filed: 2002-11-15
Granted: 2007-12-27
Abstract: The flywheel (1), comprising a support (3) mounted axially on the engine output shaft and a toothed ring (4) fixed to the support by an inner peripheral edge (6) on the ring and an outer peripheral edge (5) on the support, has a viscoelastic element (14) between radial surfaces (8, 10) of the support and ring which is compressed in radial and axial directions. The viscoelastic element is in the form of a seal held in an annular groove (15) in one of the radial surfaces surfaces, the volume of the groove being some 5 per cent less than that of the seal. The flywheel has a supplementary viscoelastic element (16) between a radial thrust surface (12) on the support and a component (2) fitted to the engine shaft.
Patent DE-60219796-T2 (DE)
Inventor: RAY RANJAN
IPC: C22C19/05
Filed: 2002-06-07
Granted: 2008-01-17
Abstract: Methods for making various nickel based superalloys into engineering components such as rings, tubes and pipes by melting of the alloys in a vacuum or under a low partial pressure of inert gas and subsequent centrifugal casting of the melt in the graphite molds rotating along its own axis under vacuum or low partial pressure of inert gas are provided. The molds have been fabricated by machining high density, high strength ultrafine grained isotropic graphite, wherein the graphite has been made by isostatic pressing or vibrational molding.
Patent DE-60221969-T2 (DE)
Inventor: DAVIES DAVID THOMAS
IPC: A61K31/4545
Filed: 2002-01-22
Granted: 2008-04-30
Abstract: Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
Patent DE-60300512-T2 (DE)
Inventor: LACROIX LOUIS
IPC: B60H1/00
Filed: 2003-02-25
Granted: 2006-02-23
Abstract: The control board has three concentric control buttons which operate electrical contacts and valves. An internal button (20) is directly connected to a disk bearing electrical contacts and an intermediate button (9) operates an air valve through a pinion (34), a worm (36) and toothed sector (37). An external button (7) also operates an air or mixer valve through a pinion (41), a worm (43) and toothed sector (44).
Patent DE-60315897-T2 (DE)
Inventor: GRADEL THOMAS
IPC: A61F2/00
Filed: 2003-12-16
Granted: 2008-05-15
Abstract: The implant consists of a body (1) of solid biocompatible material, basically tubular in shape with convex upper and lower walls and side walls, all diverging slightly towards front, rear wall(6) with threaded hole and inner cavity. The upper and lower walls have apertures, and threaded hole is designed to receive interchangeable titanium compression plug(19) for bone graft placed in inner cavity. The implant consists of a body (1) of a solid biocompatible material, basically tubular in shape with convex upper and lower walls and side walls, all diverging slightly towards the front, a rear wall (6) with a threaded hole and an inner cavity. The upper and lower walls have apertures, and the threaded hole is designed to receive an interchangeable titanium compression plug (19) for a bone graft placed in the inner cavity. The length of the plug is such that its inner end (20) penetrates by up to a quarter of its length into the cavity.
Patent DE-60319004-T2 (DE)
Inventor: DEVRIES ROBERT B
IPC: A61B1/00
Filed: 2003-08-21
Granted: 2009-01-29
Abstract: Endoscopic devices and methods used for fastening multiple tissue layers, such as, for example, an endoscopic fundoplication procedure, are disclosed. The device may include, for example, an elongated tubular member having a proximal end for extending outside of the body and a distal end for positioning proximate the multiple tissue layers, a grasper configured for positioning proximate the distal end of the tubular member and for grasping at least one of the multiple tissue layers, a device coupled to the distal end of the tubular member for folding the multiple tissue layers together, a tissue fastener configured to be inserted into the tissue layers to hold the tissue layers together, and a fastener head for inserting the tissue fastener into the tissue layers.
Patent DE-60320388-T2 (DE)
Inventor: HEMMILAE ILKKA
IPC: C12Q1/68
Filed: 2003-02-28
Granted: 2009-05-28
Abstract: The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a beta-diketone of formula I wherein R<SUB>1 </SUB>is an aryl, optionally mono- or multi-substituted, and R<SUB>2 </SUB>is a straight or branched alkyl chain with 2 to 9 carbon atoms substituted with four or more fluorine atoms. The invention further relates to a bioaffinity assay using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection comprising the use of said enhancement solution.
Patent DE-68902539-T2 (DE)
Inventor: GASTOLDI PAOLINO
IPC: B65H19/28
Filed: 1989-12-20
Granted: 1992-12-24
Abstract: It is provided a device including: two winding cylinders (2, 3) establishing an operating zone (4) between one another for the formation of a roll (6) of fabric, external to said operating zone (4) developping an initial fabric edge (11), feeding members (7a) suitable for locating a tubolar element (7) into a first feeding position (7b) external to said operating zone (4) and in contact to said initial edge (11), lifting means (12) suitable for turning said initial edge (11) onto said tubolar element (7) in said first position (7b) and thrust means (17) suitable for rolling said tubolar element (7) from said first position (7b) until said operating zone (4). The process includes a first partial pre-winding of the fabric by the turning of said initial edge (11) onto said tubolar element (7) in static position, and a following second pre-winding by means of the rotation/ traverse of said tubolar element (7) from said first position (7b) to said operating zone (4).
Patent DE-68907687-T2 (DE)
Inventor: LOVRECICH MARA LUCIA
IPC: A61K9/18
Filed: 1989-10-17
Granted: 1993-10-28
Abstract: A poorly soluble medicament is incorporated into particles of a crosslinked polymer which is swellable in water but insoluble in water, and the product obtained is brought into contact with a solvent able to swell the polymer. The product obtained by this treatment, and after being dried under vacuum, has a medicament dissolving rate which is considerably higher than that of the pure medicament.