baber/WOPTO huggingface dataset:
Patent CA-1314211-C (CA)
Title: Agent for reducing nephrotoxicity caused by cyclosporin administration
Inventor: KAKIMOTO NORIHIRO
IPC: A61P43/00
Filed: 1988-10-20
Granted: 1993-03-09
Abstract: Abstract The present invention provides (1)an agent for reducing the nephrotoxicity caused by ciclosporin administration, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I)                        (I) wherein R1 to R3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O-Y+(Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2)a method for reducing the nephrotoxicity caused by ciclosporin administration, characterized by administering, in need of such treatment, an effective amount of an organogermanium compound represented by the above formula (1).
Patent CA-1338624-C (CA)
Title: N,n'-carbonyl-bis-(4-ethyl-2,3-dioxo)-piperazine, process for the preparation thereof and use thereof
Inventor: CASTELLVI JUAN CABRE
IPC: A61K31/545
Filed: 1988-11-08
Granted: 1996-10-01
Abstract: A new compound called N,N'-carbonyl-bis-(4-ethyl-2,3-dioxo)-piperazine of Formula I                                                    (I) A process for the preparation thereof based on the reaction of 4-ethyl-2,3-dioxo-piperazine or a trimethyl-silyl derivative thereof with carbonyl chloride or a derivative thereof.    The use of the compound of Formula I as an intermediate in the preparation of compounds of Formula II                                     (II) where R is a radical, substituted in alpha position, of a molecule of an acid selected from the group formed by phenylacetic acid, p-hydroxy phenylacetic acid, a 6-(phenylacetamido)-penicillanic acid and a 7-(phenyl-acetamido)-cephalosporanic acid.
Patent CA-1322381-C (CA)
Title: Composite bicycle frames and methods for making same
Inventor: TRIMBLE BRENT J
IPC: A63B49/10
Filed: 1988-11-15
Granted: 1993-09-21
Abstract: Abstract of the Disclosure Disclosed is an improved bicycle frame of composite materials and a method of molding generally hollow components and assemblies for such a bicycle frame.  The entire bicycle frame may be one integrally united piece of molded composite materials, such as unidirectional structural fibers impregnated with a heat curable synthetic resin.  Layers of the composite material may be shaped to form an uncured frame shell.  This shell is compressed against the surfaces of a mold by an internal pressing member, such as an inflatable bladder routed to the outside through a passageway passing through a modified bottom bracket sleeve or a modified head tube sleeve.  The shell is then cured while under compression in the mold.
Patent CA-1341207-C (CA)
Title: Analogues of insulin-like growth factor-1
Inventor: BALLARD FRANCIS JOHN
IPC: A61K38/27
Filed: 1988-11-23
Granted: 2001-03-20
Abstract: A peptide analogue of mammalian insulin-like growth factor-1 wherein form 1 to 5 amino acid residues are absent form the N-terminal. Such peptide analogue is useful in the treatment of protein accumulation deficiencies or protein loss in mammals. Normally such deficiencies are associated with cancer, cystic fibrosis, Duchenne muscular dystrophy, Becker dystrophy, autosomal recessive dystrophy and polymyositis.
Patent CA-1321545-C (CA)
Title: Pharmaceutical compositions having antineoplastic activity
Inventor: MONTI SERGIO
IPC: A61K31/095
Filed: 1989-02-20
Granted: 1993-08-24
Abstract: Abstract PHARMACEUTICAL COMPOSITIONS HAVING ANTINEOPLASTIC ACTIVITY            Compositions containing as antineoplastic active principle only dialkyl diselenides show a very promising activity not withstanding a remarkably lower toxicity in comparison with that of known combinations of the same dial kyldi-selenides with other active principles.
Patent CA-1309121-C (CA)
Title: Gripping device for nappy materials
Inventor: KROGSTRUP JOHAN
IPC: D05B33/00
Filed: 1989-04-18
Granted: 1992-10-20
Abstract: ABSTRACT           A gripping device for gripping nappy work-pieces such as textiles and all sorts of flexible material having hair, nap, fibers or threads protruding from the surface of the material.  The device has a base part, one or more gripping elements, and a slidable member which is slidable relative to the base part and provided with a squeeze element for each of the gripping members.  The gripping members are shaped as elongated bodies which, in an area close to one of their ends, are adapted for contact against work-pieces surrounded by the squeeze elements.  The elon-gated bodies are also slotted along their longitudinal axis and by their other ends are fixed against translatory movements in the longitudinal direction relative to the base part.  The slots in the gripping members may be squeezed by the movement of the slidable part towards the work-piece.
Patent CA-1285377-C (CA)
Title: Compact casket enclosure system and method
Inventor: YEARSLEY DAVID A
IPC: E04H13/00
Filed: 1989-05-16
Granted: 1991-07-02
Abstract: ABSTRACT OF THE DISCLOSURE         To overcome problems concerning compact, inexpensive and long-term storage of entombment caskets in mausoleum crypts their is provided a extremely lightweight, yet durable enclosure for hermetically sealing caskets.  The invention includes a foldable casket tray which receives a casket.  A durable cover of wrapping material is placed over the casket and is attached and hermetically sealed to the tray.  The cover is formed with a pressure relief valve for periodic self-ventilation of gases produced by decomposition of the casket and its contents enclosed within the hermetically sealed enclosure.  When in folded condition, the tray serves as a compact shipping and storage container for the cover, a tray liner, and materials for attaching and hermetically sealing the cover to the tray.  By virtue of the hermetic seal and extreme light weight of the enclosure, the enclosure is particularly adaptable for use in more compact, lightweight and inexpensive casket storage rack systems than are presently required for above ground mausoleum crypts.
Patent CA-1289926-C (CA)
Title: Vav valve with pwm hot water coil
Inventor: NURCZYK MARK E
IPC: F24F11/06
Filed: 1989-05-16
Granted: 1991-10-01
Abstract: PATENT     Title VAV VALVE WITH PWM HOT WATER COIL                Inventor Mark E. Nurczyk Abstract A refrigeration system for temperature conditioning several comfort zones includes several VAV (variable air volume) valves each having a hot water coil conveying water whose flow rate is regulated by a PWM (pulse-width modulated) solenoid valve.  Each VAV valve is connected to a supply air duct conveying cool supply air.  When a zone's temperature is above a set point temperature, the opening of the VAV valve is modulated to meet the cooling demand, and the water coil is shut off.  When a zone's temperature is below the set point, the VAV valve is opened to provide a predetermined constant airflow rate and the hot water coil's solenoid valve is cycled open and closed in a pulse-width modulated manner to meet the heating demand.
Patent CA-1336783-C (CA)
Title: Override circuit for medical table
Inventor: ZELINA FRANCIS J
IPC: G05B19/4063
Filed: 1989-05-17
Granted: 1995-08-22
Abstract: A medical table having an override circuit includes control circuits for generating control signals in response to user input.  Switches are provided for generating control signals in response to user input.  Mechanical actuators, responsive to the control signals, move the medical table.  An override circuit electrically isolates the control circuits from the mechanical actuators in response to the generation of control signals by the switches.
Patent CA-1328871-C (CA)
Title: Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
Inventor: FLIRI ANTON F J
IPC: C07D417/12
Filed: 1989-05-23
Granted: 1994-04-26
Abstract: ABSTRACT OF THE DISCLOSURE             Acyl derivatives of 2-aminobenzothiazole and alkylated analogs of the formula:                                  ---I                                             ---II                                               ---III     or   ---IV            (wherein X is alkyl, hydrogen, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, nitro, trifluoromethyl, carbamyl, N,N-dialkylcarbamyl, phenyl, fluorophenyl, methoxy-phenyl, hydroxyphenyl, cyano, cyclohexyl or hydroxy-alkyl;     Y is  hydrogen, alkyl, alkoxy, F or C1;          W is  hydrogen, alkoxy, cyano, F, C1 or Br;          X and Y together may form a benzo or tetrahydro-benzo ring;          Z is  hydrogen, F, C1, Br or alkyl;          R is  a substituent of the formula:                   -(Q)-(CH2)pNR4R5 [where n is an integer of 0 to 2; m is an integer of 0 to 1;               R3, R4 and R5 are each hydrgoen alkyl;               Q is CH2, O, NR4 or S; p is an integer of 2 to 3;      R4 and R5     together with the nitrogen may form a saturated heterocyclic]      R1 is hydrogen or methyl;      R2 is hydrogen, alkyl, nitro, cyano, trifluoromethyl, F, C1 or Br; and R6 is alkyl, alkoxycarbonylmethyl, with the proviso that in formula I, R is at the m- or p-position to the carbonyl and p is 2 or 3 when Q is O, NR4 or S) are use-ful as antitumor agents and anti-plasmin agents.
Patent CA-1323466-C (CA)
Inventor: EHMIG GERHARD
IPC: B25C1/18
Filed: 1989-06-09
Granted: 1993-10-26
Abstract: ABSTRACT         An explosive powder actuated setting device having a driving piston which is displaceable between a ready-to-fire position and a fired position within a barrel formed by a piston guide.  When the piston is driven from the ready-to-fire position into the fired position, it is held by braking halls supported in recesses in the piston guide.  As it moves into the fired position, the piston moves the braking balls into the range of a spring which biases the balls inwardly against the shank of the piston.  When the piston is returned into the ready-to-fire position, the balls move out of the range of the spring releasing the biasing force acting on the piston shank via the balls.
Patent CA-1338483-C (CA)
Inventor: MONTAGUE PETER GRAHAM
IPC: C08F226/02
Filed: 1989-06-12
Granted: 1996-07-23
Abstract: A process for the polymerization of polymers containing at least one hydrophilic monomeric component and at least one hydrophobic monomeric component comprising the step of polymerizing the monomers in the presence of free radical polymerization initiators in an aqueous medium consisting of water and a cosolvent, wherein the amount of cosolvent is monitored so as to maintain the ratio of water to cosolvent equal or greater than unity during the reaction, thereby keeping the polymer as it forms in a sufficiently mobile condition and preventing homopolymerization and precipitation of the polymer from the hydrophobic monomer, thereby producing a polymer as a relatively high solids, low viscosity,opaque or semi-opaque product which is suitable and slightly cloudy, opaque or semi-opaque, which exhibits no gelling, coagulation or product separation on standing and which, upon dilution to 0.25% solids content W/W, has a turbidity of at least 10 Nephelometric Turbidity units.
Patent CA-1324162-C (CA)
Inventor: POLLICH GERHARD
IPC: B65H9/06
Filed: 1989-07-20
Granted: 1993-11-09
Abstract: Device for adjusting front lays ABSTRACT            Especially with fast running printing machines torsional vibra-tions and bending vibrations of great amplitudes of the front lay shaft carrying the front lays may cause alignment errors and damage to the leading sheet edge. The invention counteracts these phenomenons by providing an additional supporting bearing for the front lay shaft which follows the changing positions of the ad-justably arranged front lay shaft and by locating the working point of a swivel device for swivelling the front lay shaft about its longitudinal axis in the immediate proximity to the additional supporting bearing. (Fig. 1)
Patent CA-1319679-C (CA)
Title: Mixing device and method for its manufacture
Inventor: KENNEDY RICHARD B
IPC: B01F7/16
Filed: 1989-08-03
Granted: 1993-06-29
Abstract: ABSTRACT OF THE DISCLOSURE         An improved mixing device for mixing at least two of a plurality of pressurized liquids, the device consisting of hollow tubular member defined as having a longitudinal axis, one or two open ends and an interior wall member, one of the open ends having at least two cut-out portions generally symmetrically disposed about the axis, a segmental slot member generally radially disposed in the hollow tubular member between each of the cut-out portions for receiving a supporting projection in locking engagement therewith, and an envelope mounted on and extending about each of the cut-out portions for receiving and encompassing a conduit member terminating at and within each of the cut-out portions, each envelope being disposed, constructed and arranged for directing one of the plurality of pressurized liquids onto a proximate area of the interior wall means thereof.  The wall is cleaned by turning off the fluid flow but the blades continue to be rotationally driven whereby the wall is wiped clean by the blades which push the residue out the tubular members.
Patent CA-1323534-C (CA)
Inventor: HOLSCHUH MARK T
IPC: F02B61/04
Filed: 1989-09-08
Granted: 1993-10-26
Abstract: ABSTRACT    A compression release mechanism for an internal combustion engine wherein a rotatable pin positioned axially parallel to the camshaft is rotatably received in the camshaft lobes, and has an auxiliary cam surface mounted at an axial end thereof.  The auxiliary cam surface is adapted to extend above the outboard camshaft lobe to engage one of the valve lifters to thereby activate a compression release valve when the rotatable pin is rotated to a first position in response to low engine speed.  The pin is rotated to a second position in response to high engine speed whereby the auxiliary cam surface is adapted so as not to engage the valve lifter.  The pin is rotated by means of a centrifugally activated flyweight in response to engine speed.
Patent CA-1331632-C (CA)
Title: Cement composition
Inventor: BEALE JAMES
IPC: C04B28/06
Filed: 1989-09-18
Granted: 1994-08-23
Abstract: ABSTRACT OF THE DISCLOSURE:          In a composition to form a hardened cement (the composition comprising two slurries to be mixed together) selection of a specific phase for the  first slurry leads to certain advantages in terms of cost and efficiency.  To achieve this, the first slurry in chosen to comprise water and a cement component comprising ferrite and C12A7 or C11A7CX2 (where X is a halogen atom) and a reactive source of silica, while the second slurry comprises water, beta anhydrite, calcium oxide and/or calcium hydroxide.
Patent CA-1320289-C (CA)
Title: Framing algorithm for bit interleaved time division multiplexer
Inventor: BAINS KULDIP S
IPC: H04J3/16
Filed: 1989-09-21
Granted: 1993-07-13
Abstract: ABSTRACT OF THE DISCLOSURE       Methods are provided for multiplexing a plurality of channels onto a sub-aggregate of and aggregate line so as to substantially minimize total frame length.  In a preferred method, channel data rates are expressed as a sum of a plurality of predetermined subchannel data rates, and the number of times each predetermined subchannel data rate is used to express a channel data rate of a channel to be multiplexed is accumulated.  Given a predetermined primary frame rate (P) such as 8Khz for a DACS compatible multiplexer, and a tertiary frame rate (T) chosen as the greatest common denominator of the subchannel data rates, an optimal secondary frame rate (S) may be found by minimizing for a plurality of different secondary frame rates the sum of (P/S)F1 plus (S/T)F2, where F1 represents the number of calls of the primary frame to the secondary frame, and F2 represents the number of calls of the secondary frame to the tertiary frame.          Where different primary frame rates may be used, the sum of (A/P) plus (P/S)F1 plus (S/T)F2 is minimized to find primary and secondary frame rates which will permit an optimally small total frame length, given the sub-aggregate rate A.
Patent DK-162922-C (DK)
Inventor: TRIPP EDWARD S
IPC: B65D23/00
Filed: 1985-03-07
Granted: 1992-05-25
Abstract: A stoppered drug vial forms part of a drug delivery system which maintains the sterility of the drug in storage, dilution and use. A removable, pierceable diaphragram is placed over the stopper which seals the vial. The removable, pierceable diaphragm is held in place by attachment to a skirt member which encloses and is in frictional contact with the upper portion of the vial wall. Access to the drug in the vial may be obtained by either removing the diaphragm and the stopper or piercing the diaphragm and the stopper with a cannula.
Patent FI-75147-C (FI)
Inventor: GRIES HEINZ
IPC: C07C237/32
Filed: 1981-01-07
Granted: 1988-05-09
Abstract: 1. Compounds of the general formula I   see diagramm : EP0032387,P17,F5   in which X represents the radical -CO.N.R1 R2 , -CCOR3 , -CH2 .NH.R7 or -CH2 OH, Y represents the radical -N.R1 R2 or -OR3 , Z represents the radical -N.R1 R2 , -NH.R7 , -NH.(sugar radical) or -OR3 , -N.R1 R2 in X, Y and Z being the same or different, R1 and R2 are the same or different and represent a hydrogen atom or a straight-chain or branched-chain alkyl radical having from 1 to 6 carbon atoms or a mono- or polyhydroxylated straight-chain or branched-chain alkyl radical having from 2 to 8 carbon atoms and from 1 to 5 hydroxy groups, R3 represents an alkyl radical having from 1 to 4 carbon atoms or a hydroxylated alkyl radical having from 2 to 4 carbon atoms and from 1 to 3 hydroxy groups, and R7 represents the acyl radical of an aliphatic carboxylic acid having from 2 to 5 carbon atoms which may optionally be substituted by from 1 to 5 hydroxy groups, it being possible for the hydroxy groups also to be functionally modified.
Patent FI-74735-C (FI)
Inventor: SCHLEIMER FRANCOIS
IPC: C21C5/46
Filed: 1984-03-02
Granted: 1988-03-10
Abstract: A method and apparatus for accelerating solid particles entrained in a carrier gas so as to maximize the velocity of the particles at the output end of a duct is presented. This maximized or optimal acceleration is achieved by varying the cross section of the duct over at least the last 5 meters upstream from the opening thereof. Preferrably, the cross section of the duct should continuously increase i.e. diverge, towards the opening. This diverging cross section is preferrably in accordance with a nonlinear function of the length.
Patent FI-86302-C (FI)
Inventor: ROBIN JACQUES
IPC: A61K31/44
Filed: 1987-03-25
Granted: 1992-08-10
Abstract: The present invention relates to novel asymmetrical esters derived from 1,4-dihydrophyridine-3,5-dicarboxylic acid, of the formula: <IMAGE>  (I)  in which: R1 represents a C1-C4 alkyl group, R2 represents a C1-C4 alkyl group, a benzyl group, a benzoyl group or a phenyl group optionally substituted by one or more C1-C4 alkoxy, C1-C4 alkyl, cyano, nitro, hydroxyl or trifluoromethyl groups or by one or more halogen atoms, and R3 and R4, which are identical or different, each represent the hydrogen atom, a nitro group or a chlorine atom, their optical isomers and diastereoisomers and also the corresponding addition salts. These novel esters are useful in therapy, especially as antihypertensives.
Patent FI-85976-C (FI)
Inventor: INOUE HIROZUMI
IPC: C07D281/12
Filed: 1988-07-26
Granted: 1992-06-25
Abstract: A novel naphthpthiazepine derivative of the formula: <CHEM> wherein R<1> is a lower alkoxy group, R<2> is hydrogen atom or a lower alkanoyl group, and R<3> and R<4> are the same or different and hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable acid addition salt thereof, are disclosed. Said derivative (I) and a salt thereof are useful as hypotensive agents and/or coronary or cerebral vasodilators.
Patent FI-91610-C (FI)
Inventor: AGHAJANIAN MICHAEL KEVORK
IPC: C04B41/88
Filed: 1989-10-17
Granted: 1994-07-25
Abstract: The present invention relates to a novel process for forming metal matrix composite bodies. Particularly, an infiltration enhancer and/or an infiltration enhancer precursor and/or an infiltrating atmosphere are in communication with a filler material (2) or a preform, at least at some point during the process, which permits molten matrix metal (3) to spontaneously infiltrate the filler material (2) or preform. Such spontaneous infiltration occurs without the requirement for the application of any pressure or vacuum.
Patent FI-90852-C (FI)
Inventor: STANELLE AMBROS
IPC: B65G69/18
Filed: 1990-01-03
Granted: 1994-04-11
Abstract: PCT No. PCT/EP88/00731 Sec. 371 Date Mar. 15, 1990 Sec. 102(e) Date Mar. 15, 1990 PCT Filed Aug. 17, 1988 PCT Pub. No. WO89/01453 PCT Pub. Date Feb. 23, 1989.The system has a closure element at the lower end of a set-down cone to close the lower end of a gravity chute and a device with at least a first traction element at various distances from the lower edge of the gravity chute. The system possesses a high loading capacity and high abrasion resistance, because at least the lowest hopper has an approximately rectangular cross-section in the plane normal to the longitudinal direction of the gravity chute. The first traction element is located along a straight line in the delivery channel and is attached to the closure element in such a way that it can be guided in the open space delimited by the set-down cone and the lowest hopper.
Patent FI-92561-C (FI)
Inventor: BECKER MARK H
IPC: B23Q11/10
Filed: 1990-04-23
Granted: 1994-12-12
Abstract: A tapping attachment (1) for threading a relatively large number of holes through a sheet metal part at a relatively low cost per hole. The tapping attachment includes a thrust bearing assembly (6) which is aligned with a turret-type punch press or the like and movable in response to an axially directed force generated by the punch press. The axially directed force applied from the press to the thrust bearing assembly is transferred to a spline shaft (26). The spline shaft is rotated within and moved linearly relative to a screw threaded roller nut (74), whereby the axially directed force is converted into a rotating force for advancing and turning a tap (80) at high speeds of rotation. A nitrogen reservoir (14) is provided so that a supply of gas is available for returning the thrust bearing assembly (6) and the spline shaft (26) to their initial positions in order that a new hole can be tapped in response to another axially directed force. Also provided is an oil reservoir (12) so that a supply of oil is available for lubricating and cooling the tap (80) via an oil spout (78).
Patent FI-99226-C (FI)
Inventor: DAIRE ERICK
IPC: C08F4/60
Filed: 1991-04-10
Granted: 1997-11-10
Abstract: The present invention relates to an alpha-olefin prepolymer catalytically active in an alpha-olefin (co-)polymerization comprising a transition metal, an organometallic compound and an antistatic agent. The prepolymer can be prepared by contacting the antistatic agent with a catalyst comprising the transition metal and the organometallic compound before or during an alpha-olefin prepolymerization. It can also be prepared by contacting the antistatic agent with an alpha-olefin prepolymer after a prepolymerization. It can also be prepared by a combination of the two methods. The prepolymer can be introduced into a gas phase (co-)polymerization medium for preparing polyolefin directly in a dry powder form, with a reduced amount of sheeting and agglomerates.