baber/WOPTO huggingface dataset:
Patent CN-113734680-B (CN)
IPC: B66F9/12
Filed: 2021-09-13
Granted: 2022-03-25
Abstract: 本发明公开了一种基于大数据的智能物料仓储管理系统，涉及智能仓储技术领域，包括仓库、控制中心、带有输送链及驱动机构的货架、AGV智能小车、安装于货架一侧的升降传动机构以及安装于AGV智能小车上的输送平台，本发明变革了传统的货物存取方式，基于大数据技术，利用AGV智能小车作为运输工具能够直接将位于输送平台上的货物送至对应的货架处，再利用输送平台与货架侧面设置的升降传动机构配合将货物直接运送至对应的层处，如此一来，每一个AGV智能小车就是一个小型的堆垛机，货架的布局可以更为灵活，只需对称设置即可，极大地提高了货物的存取效率。
Patent CN-113921210-B (CN)
Title: 一种大功率水冷电阻模块
IPC: H01C1/084
Filed: 2021-09-24
Granted: 2022-05-10
Abstract: 本发明属于水冷电阻领域，具体的说是一种大功率水冷电阻模块，包括电阻，所述电阻外侧套设有套管，套管和电阻之间涂有硅脂，套管外侧固连有若干固定板，固定板均匀布置在套管外侧，固定板上开设有通孔，通孔内贯穿有冷却管，冷却管首尾相接，冷却管的进水口和排水口与外界水冷系统连通；现有技术中，电阻的散热通过风冷或者水冷，对于大功率的电阻模块通常采用水冷，现有的水冷模式冷却水与电阻外壳直接接触，外壳的导热效率较低，致使散热效果较差；本发明中通过设置套管，并在套管和电阻之间填充有硅脂，提高电阻的导热效率，从而提高电阻的散热效率，改善电阻的的工作环境，使得电阻温度适宜。
Patent CN-113567076-B (CN)
IPC: B08B13/00
Filed: 2021-09-27
Granted: 2021-12-10
Abstract: 本发明提供一种用于电子测量仪器振动试验的夹具，涉及电子测量仪器检测技术领域。该一种用于电子测量仪器振动试验的夹具，包括外壳，电子测量仪器，支架，供气装置，固定机构，清理机构，外壳上方设有电子测量仪器，外壳左右两侧固定连接有支架，外壳正侧底端设有供气装置，支架顶端固定连接有固定机构，外壳两侧靠近顶端固定连接有清理机构，通过清理机构防止在振动试验过程中仪器外壳受到碰撞造成外壳损伤，本发明提供了一种用于电子测量仪器振动试验的夹具，解决了夹具不能对不同大小的仪器进行固定影响实验结果以及实验过程中仪器上的的杂物与细小零件脱落与仪器外壳之间发生碰撞导致仪器外壳损伤的问题。
Patent CN-113690002-B (CN)
IPC: H01C1/16
Filed: 2021-10-27
Granted: 2021-12-24
Abstract: 本发明公开了一种便于使用的轴旋式电位器，包括安装板，所述安装板右端等距离开有若干个安装孔，所述安装板左端中部固定连接有固定装置，所述固定装置内穿插连接有连接壳，所述连接壳内右部穿插连接有导电板，所述导电板左端上部等距离固定连接有第一引脚和两个第二引脚，所述第一引脚位于两个第二引脚之间，所述连接壳内前部与后部均固定连接有定位装置，且两个定位装置右部贯穿导电板右端并共同穿插连接有调节装置，所述定位装置右端分别贯穿调节装置的右端前部与右端后部并延伸至其右方。本发明所述的一种便于使用的轴旋式电位器，整个装置便于设备进行安装与拆卸，从而便于装置的更换或者维修，且对装置安装的稳定性高，便于装置的使用。
Patent CN-113686289-B (CN)
IPC: G01B21/08
Filed: 2021-10-27
Granted: 2022-03-22
Abstract: 本发明公开了一种牛仔布料厚度测量装置，包括机壳内设有与外界联通的测量腔，测量腔后端壁内设有控制腔，机壳上设有显示屏，机壳内设有整理机构、摇摆机构和传送机构，整理机构能够整理布料，检测整理好的布料长度，传送机构能够测量布料的厚度以及装卸布料，摇摆机构包括能够控制布料走向的连杆机构，利用设置的伸缩杆，能够随意的调节高度，从而满足各种牛仔布料的厚度测量，使得测量厚度的范围大大增加，减少误差，合理方便，并且可以通过紧压的方式排出布料之间存在的空隙，使得测量结果更加精确，加快整理的速度。
Patent CN-113817876-B (CN)
IPC: C12Q1/70
Filed: 2021-11-22
Granted: 2022-02-11
Abstract: 本发明公开了一种用于检测新型冠状病毒的扩增引物组合物及试剂盒。所述扩增引物组合物包括第一引物组与第二引物组，所述第一引物组包括第一正向引物及第一反向引物，所述第二引物组包括第二正向引物及第二反向引物，并且，所述第一正向引物、第一反向引物、第二正向引物、第二反向引物的每个序列中均有四个碱基是经过锁核酸修饰的，该四个碱基中的一个碱基是3'末端碱基，每相邻两个经锁核酸修饰的碱基之间的间距为3‑6个碱基，经锁核酸修饰的碱基为腺嘌呤和/或胸腺嘧啶。本发明还公开了用于检测新型冠状病毒的试剂盒。本发明的试剂盒具有灵敏度高、特异型强、稳定性好等特点，可用于新型冠状病毒肺炎的快速检测，应用前景广阔。
Patent CN-113886132-B (CN)
IPC: G06F11/07
Filed: 2021-12-07
Granted: 2022-04-08
Abstract: 本发明公开了一种web端错误智能修复方法、设备及计算机可读存储介质。该方法包括：获取web端发生错误时的错误数据；对所述错误数据进行加工处理，将所述错误数据归类以得到当前错误类型；将所述错误数据和当前错误类型放入预设的智能解决方案库，生成适配的目标解决方案；执行所述目标解决方案，修复web端错误。实现了及时发现已发生的错误，获取错误数据及其错误类型信息，智能生成解决方案处理错误的有益效果，提高了解决错误的时效性。
Patent CN-113980877-B (CN)
Title: 一种复配微生物菌剂及其制备方法
IPC: C12R1/125
Filed: 2021-12-28
Granted: 2022-07-01
Abstract: 本发明提供了一种复配微生物菌剂，其特征在于，包括伯克氏菌（ Burkholderia sp. M928）、短小芽孢杆菌（ Bacillus pumilus  M101）和枯草芽孢杆菌中的至少两种，其中，伯克氏菌分离自云南省橡胶树的根际土壤。该复配微生物菌剂的主要功能在于能够有效改善农作物生长的土壤环境，广泛应用于防治线虫、立枯菌等常见病虫害，提高作物吸收营养的能力，增强作物的抗病性，促进生长，提高产量和品质。
Patent CN-114066944-B (CN)
IPC: G06T7/73
Filed: 2022-01-17
Granted: 2022-04-12
Abstract: 本发明提供一种基于行人跟踪的光模块生产车间工人岗位行为分析方法，该方法包括：S10：以固定时间间隔获取目标图像，并获取该目标图像中目标的位置信息；S20：根据目标的位置信息对目标进行跟踪匹配，得到目标的运动轨迹；S30：按照目标的运动轨迹，分析目标的行为。本发明通过智能行人检测和轨迹逻辑分析，可以对工人的工作轨迹进行还原分析，如果有人离开工作岗位，进行告知告警，保证产线安全，同时也可以通过在工作时间内对员工的离岗次数进行判别，以方便对员工的考核。
Patent CN-114189599-B (CN)
Title: Dp有源光缆及处理其信号同步的方法、可读存储介质
IPC: H04N7/01
Filed: 2022-02-11
Granted: 2022-06-17
Abstract: 本申请涉及一种用于处理DP有源光缆的信号同步的方法，所述DP有源光缆包括相对设置的源端和目的端，所述源端和目的端均设有对应的低速信号转换模块和高速信号转换模块，所述方法包括：检测本端的低速信号转换模块的信号，或者检测本端的高速信号转换模块的信号；根据检测结果来判断对端是否发生过掉电；响应于判断所述对端发生过掉电，对本端的低速信号转换模块进行复位。本申请的方法能够在不进行人为重新上电操作的情况下实现重新同步，提升了用户体验。
Patent GE-P19950116-B (GE)
Title: The line for Drying, Storage and Grading of Semifinished Baikhovi Black Tea
Inventor: BABUNASHVILI ZURAB
IPC: A23F3/00
Filed: 1992-08-10
Abstract: This invention refers to food industry, in particular to baikhovi tea production.    The line for drying, storage and grading of semifinished baikhovi tea provides the weighing hoppers that are grouped so that each group is connected with the corresponding drying machine. Each weighing hopper has the form of the hollow rectangular prism the bottom of which is discharge bucket elevator. Over all the weighing hoppers there is the loading elevator made from plates interconnected with the guide by means of rolls.    The loading elevator is supplied with the starting mechanism, each whereof being dissposed over the corresponding weighing hopper, provided with lever. The guides are supplied with the groove for turning the plates and returning them into the initial position.    The groove for turning over is closed by the movable link which is fixed on the lever. The groove for returning the plates into the initial position is closed by the hinged link under which the inclined guide is provided.    7 fig.
Patent GE-P19980870-B (GE)
Title: Converter of Reciprocating Motion to Small Rotary Motion
Inventor: DIDEBULIDZE ALEXANDRE
IPC: F16H31/00
Filed: 1993-12-02
Abstract: This invention refers to mechanical variation speed non-friction transmission of continuous action and can be used for obtaining low-frequency rotations and variation speed adjusting.    Technical result of the invention is to increase reliability of the design and efficiency and also to reduce specific quantity of metal.    The invention comprises a mechanical pulse generator made in the form of electromagnetic vibrator of angular oscillations which consists if stator 2 and rotor 3, with this fixedly mounted on vibrator shaft 4 the driving gear wheel 5 is engaged with intermediate gear wheels mounted on two different shafts 6-1 and 6-2 hubs of which are counter acting overrunning clutches 7-1 and 7-2 and by their means the intermediate gear wheels are connected with driven gear wheels 8-1 and 8-2 engaged one of which is engaged with gear 12 of power take-off shaft 13.    1 fig.
Patent GE-P19981426-B (GE)
Title: Container in the Form of Joint Toy
Inventor: FERRERO PIETRO
IPC: B65D81/36
Filed: 1993-08-16
Abstract: Widening of functional capabilities.            2. Essence Container comprises hollow body 2 and 3 and mounted thereon not less than one additional body 6 and 7 designed for imparting the container the form of a man or an animal. At least one additional body 7 has possibility of movement along the circular path available in the body and circular rotation around the axis radially directed towards the body surface having possibility of changing the disposition of the rotation axis during the movement along the circular path.              3. Field of Application Packages, in particular, pastries.          12 dep. cl., 7 ill.
Patent GE-P20063877-B (GE)
Title: Charge for fiberglass production
Inventor: GABUNIA LAMARA
IPC: C03C13/00
Filed: 2004-09-29
Abstract: A charge comprises andesite, limestone or chalk or marble and silica sand in the following proportion of components, mass %: Andesite 76-83 limesto   ne or chalk or marble 17-24 silica sand 0-5 Tabl  es: 2
Patent GE-P20094780-B (GE)
Title: Prostaglandin nitrooxyderivatives
Inventor: DEL SOLDATO PIERO
IPC: C07C405/00
Filed: 2004-12-27
Abstract: Prostaglandin nitrooxyderivatives having pharmacological compositions and its use for the treatment of glaucoma and ocular hypertension.               Tables: 3
Patent GE-P20166454-B (GE)
Title: Sclerostin binding agents
Inventor: PASZTY CHRISTOPHER
IPC: C07K16/18
Filed: 2006-04-28
Abstract: An invention relates to antibodies binding sclerostin epitopes, which crossly block Ab-C, Ab-D, Ab-13 or Ab-14 binding with sclerostin sequ¬ences SEQ ID NO: 1. Said antibodies are applied at the treatment of diseases related to abnormalities in bone mineral density and of bone mass.
Patent DK-162118-C (DK)
Inventor: BACHMANN LUDWIG
IPC: F16K1/22
Filed: 1990-03-12
Granted: 1992-02-17
Abstract: 1. Shutoff flap, comprising one one-piece metallic housing (1), the entire interior area of which is provided with an elastomer coating (13), a centrally supported metallic flap disc (5), which is within a plastic coating (6), a one-piece actuation shaft (7), which is inserted through the flap disc (5), is connected to the flap disc (5) by means of a drive type fastening (11) and is partly surrounded by the elastomer coating (15) of the housing, an upper and a lower shaft bearing (14, 15) which are located in the housing and serve to accomodate the actuation shaft (7) ; identified by the fact that the flap disc (5) is designed in one piece, that the central metallic piece (8) of the flap disc (5) is cut out in the area of the actuation shaft (7), thus leaving two opposite bearing points (9, 10) in the circumference area of the flap disc (5) for accomodation of the actuation shaft ; that, during the coating process of the flap disc (5), the cutout (8) is completely filled with the plastic (6), and that in the area of the two shaft bearings (14, 15) passage ports are (17) provided in the housing for fluid elastomer ; these ports running in the direction of the axis of the acutation shaft (7) so that the fluid elastomer flows around the shaft bearings (14, 15) during the coating process of the housing (1) and covers the shaft bearings.
Patent CA-1254227-C (CA)
IPC: C07C51/58
Filed: 1978-07-04
Granted: 1989-05-16
Abstract: ABSTRACT OF THE DISCLOSURE     The present invention provides, as new compounds, the substituted phenoxybenzyloxycarbonyl derivatives of the general formula   in which R, R1 and R2, which need not be identical, each represent hydrogen or halogen, but R and R1 cannot both be hydrogen, R3 represents phenyl or phenylthio, and in either case the phenyl ring may optionally carry one or more substituents selected independently from alkyl groups and halogen atoms, Y represents hydrogen or nitrile, n represents 1, 2, 3, 4 or 5 and m represents 1, 2, 3 or 4 They are produced by reacting a phenoxybenzyl alcohol with y cyclopropane-carboxylic acid derivative by reacting a phenoxybenzyl halide with a cyclo-propane carboxylic acid derivative.  The compounds of this invention are useful as pesticides, particularly as insecticides and acaricides, are well-tolerated by plants and have a favourable level of toxicity to warm-blooded animals.
Patent CA-1340326-C (CA)
Inventor: SUZUKI FUMIO
IPC: A01N47/36
Filed: 1983-02-24
Granted: 1999-01-19
Abstract: Disclosed is a novel pyrazolesulfonylurea derivative represented by the formula (I), preparation thereof, a herbicide containing said derivative as an active ingredient and a herbicidal method by use thereof.               (wherein A, B, C, D, X, Y and Z are as defined in the specification)
Patent CA-1277689-C (CA)
Title: Segmented seal for rotary equipment
Inventor: NIXON ROBERT J JR
IPC: F16J15/26
Filed: 1985-04-30
Granted: 1990-12-11
Abstract: ABSTRACT OF THE DISCLOSURE            SEGMENTED SEAL FOR ROTARY EQUIPMENT            A seal assembly for effecting a seal between a stationary housing and a rotatable cylinder includes a plurality of arcuate segments radially disposed about the outer circumference of the cylinder.  Each segment has an axial sealing surface defining a radius approximately equal to that of the rotatable cylinder and additionally has an end section for overlapping adjacent segments thus creating a gap and radial interface between the adjacent circumferentially disposed segments.  The sealing assembly additionally comprises means for sealing the gaps formed by the adjacent overlaping segments, apparatus for tensioning the segments radially about the outside circumference of the cylinder and studs for removably attaching each segment to the housing while concurrently permitting radial displacement of each segment independently from its adjacent segments.
Patent CA-1281552-C (CA)
Title: Further improvements in tungsten recovery
Inventor: ANDERSON DIANA M
IPC: C22B34/36
Filed: 1986-03-25
Granted: 1991-03-19
Abstract: ABSTRACT     Further Improvements in Tungsten Recovery The scarcity of high grade tungsten ores obliges users to seek to recover it from scrap materials, but drill bits in particular pose especial problems.  Existing proposals to use acidic hydrogen peroxide to oxidise and solubilise tungsten is extremely inefficient in reagent consumption per unit tungsten recovered.      According to the present invention, hydrogen peroxide can be used considerably more efficiently in the extraction of tungsten into an aqueous acidic solution by employing certain promoters which are solid at 50°C in the form of fused blocks.  These blocks release the promoter slowly into the reaction solution and achieve similar efficiency of use of hydrogen peroxide and acid but at markedly reduced consumption of promoter in comparison with the same promoter added in powder or granular form.  Examples of such promoter are hydroxy or amino substituted aromatic carboxylic acids e.g. 2-hydroxybenzoic acid.  The promoter can most conveniently be used in a multi-stage tungsten extraction process.
Patent CA-1298730-C (CA)
Title: Agglomeration method and apparatus
Inventor: NOREILLE PHILIPPE
IPC: A23F5/38
Filed: 1986-06-02
Granted: 1992-04-14
Abstract: Abstract Agglomeration method and apparatus A particulate comestible material is agglomerated by forming a flowable phase on the particle surfaces, consolidating the particles by passing them through a nip and resolidifying the flowable phase. The color, texture and density may be adjusted by controlling the degree of consolidation and the conditions of flowable phase formation.
Patent CA-1276596-C (CA)
Title: Container for measuring antibodies or antigens to a biological liquid
Inventor: RINGROSE ANTHONY
IPC: G01N33/553
Filed: 1986-07-07
Granted: 1990-11-20
Abstract: ABSTRACT OF THE DISCLOSURE A  container  for determining antibodies or antigens in  a  biological liquid  by the formation of specific antibody-antigen complexes,  in  which one partner element is initially associated with suspended magnetic  parti-cles  that are subsequently regrouped against a certain area of one wall of the container when the container is positioned within a magnetic field that extends through that area of the wall.  To prevent the particles from  sli-ding  down  when  the magnetic field is eliminated and to  allow  effective pipetting,  the lower part of said area of the wall is adjacent to a  plane surface  that  is at an obtuse angle to said wall and tangent to a  concave surface  that is itself tangent to a wall of the container opposite to  the wall that is at an obtuse angle.
Patent CA-1278581-C (CA)
Inventor: AKAHANE SHOJI
IPC: A61K6/083
Filed: 1986-08-25
Granted: 1991-01-02
Abstract: ABSTRACT OF THE DISCLOSURE        A  fluoroaluminosilicate  glass  powder  for dental glass  ionomer  cement, a surface of which is treated with a fluoride  in  an  amount  of  from 0.01 to 5 parts by weight based  on  100  parts  by  weight  of  the  glass powder, is disclosed.   The  fluoroaluminosilicate  glass Powder of the invention  is  improved in not only physical properties such as  crushing  strength but also  mixing  workability without impairing  the inherent characteristics thereof for the den-tal use.
Patent CA-1288007-C (CA)
Title: Propeller tunnel baffle and method
Inventor: SMALL MARK S
IPC: F01N13/12
Filed: 1986-08-26
Granted: 1991-08-27
Abstract: Abstract of the Disclosure:            A marine  craft  having a propeller tunnel  in which the sidewalls  of  the  tunnel  are  essentially  parallel  and vertical and mate with a descending upper surface of the tunnel  which  optionally  can be  divided  into a  transom plate  portion,  engine plate  portion,  and bottom plate portion.  The bottom plate portion mates with the bottom of  the  boat  hull  in  a  sharp  line  intersection.   A surfacing propeller and associated drive shaft is mounted in  the  tunnel  with  a  rudder  positioned  aft  of  the surfacing propeller.  Baffles are provided on the lateral sides of the tunnel and terminate in a forward portion aft of the bottom plate portion of the tunnel.  Optionally the exhaust can be vented onto the bottom plate portion of the tunnel  to augment  the  flow of  air.   The method of  the invention is directed to forcing the flow of air inside a surfacing propeller  tunnel  on  a boat  to  the  end  that baffles provided on the lateral side are fed by air from the  transom portion  of  the  baffle  and  induced by  the forward motion of the boat as well as the pneumatic effect of  the surfacing propeller portion which is not in the water to force the air to go into the tunnel portion and thereby minimize  any  negative  pressure  build-up  which would otherwise occur absent of venting.  In addition the method  contemplates  augmenting  the pressure within  the tunnel by directing the exhaust to a forward portion of the tunnel.
Patent CA-1281572-C (CA)
Title: Method of making a wound container
Inventor: GILLARD DAVID F
IPC: B29C53/58
Filed: 1986-09-03
Granted: 1991-03-19
Abstract: METHOD OF MAKING A WOUND CONTAINER          ABSTRACT OF DISCLOSURE           Method  of  improving  the  effectiveness  of  the adhesive joining a first layer forming an inner lining of a wound container to the next  adjacent  layer comprising laterally  spreading  the  web  material  forming  the  first layer  while winding same  under tension to substantially eliminate  relative  lateral  movement  between  the  liner layer and the next adjacent layer as the adhesive is being set and thereby improve the bonding.
Patent CA-1284089-C (CA)
Title: Glass fiber-reinforced electrical laminates and a continuous production method therefor
Inventor: FUSHIKI YASUO
IPC: C08G59/22
Filed: 1986-09-26
Granted: 1991-05-14
Abstract: Abstract of the Disclosure There is provided an electrical laminate comprising a cured assemblage of a plurality of glass fiber type substrates impregnated with a curable resin composition containing (a) a halogenated bisphenol type unsaturated polyester resin and (b) an epoxy acrylate resin which may optionally be halogen-containing.  This laminate features high dimensional stability, improved through-hole reliability, and excellent mechanical strength.  A continuous production method for laminates is also described.
Patent CA-1289962-C (CA)
Title: 5-heterocyclic-2,4-dialkyl-3h-1,2,4-triazole-3- thiones and their use as antidepressants
Inventor: KANE JOHN M
IPC: A61P25/26
Filed: 1986-10-24
Granted: 1991-10-01
Abstract: ABSTRACT This invention relates to novel 5-Rn?Het?2,4-dialkyl-3H-1,2,4-triazole-3-thiones of the formula: or a tautomer thereof, or a pharmaceutically acceptable salt thereof, wherein R is halogeno, C1-6 lower alkyl, C1-6 lower alkoxy, hydroxy or trifluoromethyl; n is 0, 1 or 2; R2 and R4 each independently represents C1-6 lower alkyl or hydrogen; and Het represents a heterocyclic moiety; and to intermediates therefor and to processes for their preparation, and to their use as antidepressants.
Patent CA-1279261-C (CA)
Title: Orally administerable sustained release pharmaceutical formulations
Inventor: THAKKAR ARVIND L
IPC: A61K9/48
Filed: 1986-11-10
Granted: 1991-01-22
Abstract: Abstract of the Disclosure This invention provides orally administerable pharmaceutical formulations having a semi-solid matrix containing a hydrophilic substance capable of creating channels in a hydrophobic carrier matrix thereby provid-ing a sustained rate of release of an active agent from the formulation.
Patent CA-1280437-C (CA)
Title: Process for the co-production of aromatic carboxylates and alkyl iodides
Inventor: RULE MARK
IPC: C07B61/00
Filed: 1986-11-18
Granted: 1991-02-19
Abstract: Abstract Process for the Co-Production of Aromatic Carboxylates and Alkyl lodides Disclosed is a process for the co-production of aromatic carboxylates and alkyl iodides by the carbonylation of aromatic iodides in the presence of an alkanol and a nickel catalyst.
Patent CA-1291338-C (CA)
Title: Condensate disposal system
Inventor: O'MARA RAYMOND D
IPC: F24F13/22
Filed: 1987-04-22
Granted: 1991-10-29
Abstract: CONDENSATE DISPOSAL SYSTEM                           ABSTRACT            In an air conditioning system having a condensate tube interconnecting a condensate pan and a trap, a vent is provided in the condensate tube for relieving any internal pressure which would otherwise cause a restriction of condensate flow within the condensate tube.
Patent CA-1298734-C (CA)
Title: Spin-damped training round with selectable safety trace
Inventor: BUCKLAND WILLIAM R
IPC: F42B10/54
Filed: 1987-04-28
Granted: 1992-04-14
Abstract: Abstract High velocity projectiles are able to continue in flight for considerable distances beyond the normal target range.  The present invention is a projectile for use in practice firing which becomes unstable after the normal target range has been exceeded and comprises a training round (1) having a body portion (3) engageable with a sabot (4) for projection from a rifled gun barrel, and a tapered nose portion (2) protrusive beyond the sabot, which is provided with a nose tip portion (6) having spin fins (9) extending in planes radial to the longitudinal axis.  The fins increase the rate of spin decay and cause instability of the round and the fin geometry is chosen such that the instability occurs when the target range has been exceeded.  The finned nose tip portion is separable from the round so as to permit selective attachment of a nose tip portion having fins specifically dimensioned for terminating the trajectory at a chosen safety range.
Patent CA-1275750-C (CA)
Title: Dense star polymers for calibrating/characterizing sub-micron apertures
Inventor: TOMALIA DONALD A
IPC: C08G69/44
Filed: 1987-05-29
Granted: 1990-10-30
Abstract: ABSTRACT         The present invention relates to processes for calibrating and characterizing substances having apertures ranging between 0.008 to 10 µm.  These substances include discrete biological particles such as viruses, enzymes and proteins and other diverse subcellular components such as biological channels made of membrane proteins which allow nutrients, ions and other essential materials into plants or animal cells. This invention also relates to the novel covalently bridged dense star polymers or dendrimers that are exposed in the process.       Present techniques for calibrating or measuring the apertures of such channels have met with only limited success because of the difficulty of designing a spherical structure as small as, for example, a cell channel (0.0015 to 0.002 µm).  Such known techniques employ structures which are randomly coiled and tend to reptate or unravel when contacted with an aperture of a size smaller than the measuring structures.  This unraveling of these measuring structures, in turn, 33,886-F     induces tremendous variations in measurements, requiring weeks and even months to perform.  Such known measuring structures include nonspherical, low molecular weight compounds and proteins.  The use of these reptating or unraveling structures as probes leads to serious doubt as to the validity of the measured molecular diameters. The process of the subject invention, employing the novel covalently bridged dense star polymers, provides a precise, accurate and reliable method for calibrating and characterizing substances having submicron apertures.  The process comprises contacting said substances with a plurality of the novel dense star polymers, passing through the aperture of said substances at least one dense star polymer having a molecular diameter which is equal to or less than the diameter of said aperture and calculating the diameter of said aperture from measurements of either those dense star polymers passing through or into said aperture, of those polymers not passing through, or of the combined measurements of those dense star polymers pa sing through or into said aperture and those not passing through or into.   33,886-F