baber/WOPTO huggingface dataset:
Patent CA-3172903-A1 (CA)
Title: Process for the preparation of (r)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)-cyclopropyl) benzoic acid or a salt thereof
Inventor: ROVATI LUCIO CLAUDIO
IPC: C07D221/20
Filed: 2021-03-19
Abstract: The present invention provides a process for preparing (R)-6-(tert-butoxycarbonyl)-6- azaspiro[2.5]octane-5-carboxylic acid (SM1), said process comprising the step of: iv) converting a compound of formula (VII) into a compound of formula (VIII) using a Wittig reagent in a suitable solvent; v) reacting through the Makosza reaction the compound of Formula (VIII) using bromoform and a suitable base to obtain cyclopropane compound of Formula (IX); and vi) removing bromine atoms in the presence of a reducing agent and a base in an alcoholic solvent thus obtaining (SM1). The invention relates also to a process for the conversion of the compound (SM1) for preparing (R)- 4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl) benzoic acid (IV) or a salt thereof. The salt is preferably the sodium salt, more preferably the polymorphic form A of sodium (R)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6- azaspiro[2.5]octane-5-carboxamido)-cyclopropyl) benzoate characterized by a powder XRD spectrum with peaks at values of the angle 2? ±0.2° of 4.3, 5.0, 5.8, 6.4, 7.1, 8.3, 8.7, 12.8, 15.3, 15.9.
Patent CA-3174726-A1 (CA)
Title: Connection arrangement for closed system transfer of fluids
Inventor: MCKINNON AUSTIN JASON
IPC: A61J1/14
Filed: 2019-03-19
Abstract: A patient connector comprising a body haying a first end and a second end; a patient connection extending from the second end of the body, the patient connection configured to secure the body to a patient line; and a collet connection extending toward the first end of the body.
Patent CA-3178417-A1 (CA)
Title: Anti-cd200r1 antibodies and methods of use thereof
Inventor: CHEN YU
IPC: C12N15/13
Filed: 2021-05-28
Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD200R1 receptor protein (hu-CD200R1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD200R1. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD200 binding to CD200R1.
Patent CA-3179423-A1 (CA)
Title: Methodes et compositions d'arn circulaire
Inventor: WESSELHOEFT ROBERT ALEXANDER
IPC: C12N15/64
Filed: 2021-05-19
Abstract: L'invention concerne l'ARN circulaire ainsi que des compositions et des méthodes associées. Dans certains modes de réalisation, l'ARN circulaire de l'invention comprend des fragments d'intron du groupe I, des espaceurs, un IRES, des régions de formation de duplex et une séquence d'expression. Dans certains modes de réalisation, la séquence d'expression code pour un antigène. Dans certains modes de réalisation, l'ARN circulaire de l'invention présente une expression améliorée, une stabilité fonctionnelle améliorée, une immunogénicité améliorée, une facilité de préparation améliorée et/ou une demi-vie améliorée lorsqu'il est comparé à un ARN linéaire. Dans certains modes de réalisation, les procédés et les constructions de l'invention entraînent une efficacité de circularisation améliorée, une efficacité d'épissage améliorée et/ou une pureté améliorée par rapport aux approches de circularisation d'ARN existantes.
Patent CA-3179755-A1 (CA)
Title: Implant d'ancrage osseux a expansion optimisee
Inventor: LACAZE GUILLAUME
IPC: A61C8/00
Filed: 2021-04-08
Abstract: La présente invention a pour objet un implant d'ancrage osseux à expansion optimisée, comprenant un corps tubulaire (2) et une tige (1) dont les profils extérieur de la tige (1) et intérieur du corps tubulaire (2) sont complémentaires, l'implant étant expansible entre une configuration de repos dans laquelle un mécanisme de butée verrouille réciproquement ledit corps tubulaire (2) et ladite tige (1) grâce à l'inversion de leurs deux pas de vis respectifs, de sorte qu'ils fournissent dans une configuration expandue radialement : Un point d'appui proximal, Un point d'appui distal, Un point d'appui « central » localisé entre ces deux points d'appuis, formé par la coopération entre le diamètre externe de la tige (1) et le diamètre interne du corps tubulaire (2) qui induisent un diamètre externe du corps tubulaire (2) au niveau « central » supérieur au diamètre externe du corps tubulaire (2) au niveau du point d'appui proximal.
Patent CA-3179997-A1 (CA)
Title: Detecting tampering in assets and authenticating authorized users
Inventor: VOLKERINK HENDRIK J
IPC: G06K19/077
Filed: 2021-05-25
Abstract: In some implementations, a wireless sensing system may receive sensor data associated with an asset. The sensor data may be associated with a tampering event and the tampering event may include an action performed on the asset. The wireless sensing system may further determine whether the tampering event is performed by an authorized user of the wireless sensing system. The wireless sensing system may further determine whether the tampering event is performed within an authorized location of the wireless sensing system. The wireless sensing system may transmit a notification to a user of the wireless sensing system. The notification may alert the user of the wireless sensing system that the tampering event has occurred.
Patent CA-3180308-A1 (CA)
Title: Connecting arrangement between components of an aircraft engine
Inventor: MENHEERE DAVID
IPC: F02C7/20
Filed: 2022-10-27
Abstract: An aircraft engine comprises a casing extending circumferentially around a central axis.  A support flange is secured to the casing and extends circumferentially around the axis.  The support flange has an inner and an outer flange face. A component is drivingly engaged by a shaft of the engine. The component has a connecting section extending around the central axis. The connecting section has a connecting face. The inner flange face is in abutment against the connecting face. A retaining ring extends circumferentially around the central axis. The retaining ring is in abutment against the outer flange face of the support flange. The retaining ring has a coefficient of thermal expansion, which is less than that of the support flange.
Patent CA-3181012-A1 (CA)
Inventor: GUNNELS ROBERT
Filed: 2022-11-03
Abstract: An antenna system is provided. Such antenna system includes a first Vivaldi antenna element positioned in a first plane and including first and second radiating elements and a first slot disposed between the first and second radiating elements. The antenna system also includes a first signal feed electrically coupled across the first slot at a first location and a first conductive strip positioned in a second plane offset from and parallel to the first plane. The first conductive strip is positioned in the second plane such that a first longitudinal axis of the first conductive strip runs parallel to a first central axis of the first slot.
Patent CA-3181990-A1 (CA)
Inventor: JOHNSTON CODY D
IPC: B60N2/40
Filed: 2022-11-16
Abstract: A vehicle includes a vehicle frame, a saddle-type seat mounted to the frame and having a forward portion and a rearward portion, a cargo area defining a storage compartment positioned at least partially rearward of the saddle-type seat, and a rider support assembly positioned rearward of the forward portion of the saddle-type seat and vertically above at least a portion of the saddle-type seat and the storage compartment.
Patent CA-3182172-A1 (CA)
Title: Detecting utility meter orientation based on a temperature gradient of the utility meter
Inventor: KRAUS MATTHEW E
IPC: G01D4/00
Filed: 2021-07-06
Abstract: Techniques described herein detect a meter orientation based on a temperature gradient measured for a utility meter. A method for detecting a meter orientation includes determining a set of temperature measurements including a respective temperature measurement at two or more temperature sensors of a utility meter. The method further includes comparing the set of temperature measurements to a thermal fingerprint of the utility meter. The thermal fingerprint represents a baseline set of one or more temperature gradients based on the two or more temperature sensors over time. The method further includes detecting a meter orientation based on comparing the set of temperature measurements to the thermal fingerprint of the utility meter.
Patent CA-3182756-A1 (CA)
Title: Immunogenic constructs, compositions, and methods for inducing immune response
Inventor: YANTASEE WASSANA
IPC: A61K49/18
Filed: 2021-07-13
Abstract: Disclosed are immunogenic constructs including: a nanoparticle; a cationic polymer electrostatically bound to an exterior surface of the nanoparticle and a stabilizer bound to the cationic polymer or the exterior surface of the nanoparticle; and an antigen or antigen producing agent. Optionally, the constructs may include adjuvant and/or one or more functional oligonucleotide(s) (e.g., siRNA or pDNA). Also disclosed are methods of using the provided immunogenic constructs for co-delivering an adjuvant, antigen, and optionally siRNA to a cell, inducing immune response in a subject, and treating or preventing an infectious disease in a subject.
Patent CA-3185008-A1 (CA)
Inventor: LEICHNER JOSEPH MORDECHAI
IPC: A61F2/24
Filed: 2021-06-15
Abstract: Des modes de réalisation de la divulgation peuvent concerner des dispositifs, des systèmes et des méthodes pour la manipulation de feuillets à l'intérieur du corps d'un patient, y compris le déplacement de ces feuillets. Les feuillets peuvent faire partie d'une valvule cardiaque native, ou peuvent faire partie d'une valvule cardiaque prothétique qui a été préalablement implantée dans le corps du patient. Les feuillets peuvent être déplacés pour réduire la possibilité de blocage de l'accès, par lesdits feuillets, à des structures à l'intérieur du corps du patient, qui peuvent comprendre des structures cardiaques telles que des orifices coronariens, par exemple. En tant que tel, on peut obtenir un risque réduit de maladies provoquées par un blocage des structures cardiaques.
Patent CA-3185319-A1 (CA)
Inventor: FORSELL PETER
IPC: A61M5/168
Filed: 2009-10-09
Abstract: A female external genitalia stimulation system, in particular clitoris erection stimulation system, comprises a fully implantable drug delivery device for delivering a drug in relation to a erectile tissue to achieve erection thereof. The drug delivery device may comprise a catheter adapted to be implanted in the corpora cavernosa of a clitoris or in close proximity thereto in order to deliver drugs through said catheter.  Alternatively, one or more infusion needles may be disposed within and implanted along with one or more housings adjacent the patient's left and right corpora cavernosa. A reservoir and a pump may also be implanted inside the patient's body to supply the infusion needle with infusion liquid. A drive unit also adapted for implantation inside the patient's body is arranged for advancing and retracting the tip end of the infusion needle such that it penetrates the housing at least in two different penetration areas either simultaneously or in immediate time succession, thereby injecting drugs along with the infusion liquid into the patient's body for stimulating erectile tissue, in particular for stimulating clitoris erection.
Patent CA-3187883-A1 (CA)
Title: Topical composition
Inventor: DAVIS ADRIAN
IPC: A61K47/12
Filed: 2021-04-12
Abstract: There is disclosed a composition for topical application of a cannabinoid as active ingredient comprising a solution of the cannabinoid in an excipient formulation comprising a polyhydric alcohol as partition coefficient enhancer, a saturated long-chain fatty acid or alcohol thereof as diffusion coefficient enhancer, and a co-solvent, wherein the saturated long-chain fatty acid or alcohol has a carbon chain length of from C10 to C16. The composition can be used in the treatment of a variety of conditions.
Patent CA-3190566-A1 (CA)
Inventor: KOETTER ROBERT J JR
IPC: B65G1/14
Filed: 2021-08-23
Abstract: La présente invention concerne un rayonnage à fût portatif. Le rayonnage à fût portatif permet de stocker et de transporter de multiples fûts, le poids de chaque fût étant supporté par le rayonnage. Les rayonnages possèdent des cadres rectangulaires inférieur et supérieur de construction différente, dotés de montants entre eux, et de pieds et de contours correspondants de façon à ce que les rayonnages puissent être empilés. Des lattes insérées dans des rainures peuvent retenir des fûts contenus à l'intérieur des rayonnages.
Patent CA-3192120-A1 (CA)
Inventor: WILLIAMS JAMES A
IPC: C12N15/86
Filed: 2021-09-10
Abstract: La présente invention concerne de nouvelles combinaisons d'amplificateurs et de promoteurs spécifiques des muscles utiles pour obtenir une expression élevée et persistante dans des tissus musculaires ou des myocytes. Les éléments promoteurs spécifiques des muscles sont dérivés d'un promoteur desmine. Les éléments activateurs spécifiques des muscles sont dérivés d'un promoteur desmine et d'un activateur de la créatine kinase musculaire.
Patent CA-3193210-A1 (CA)
Inventor: BUATOIS VANESSA
IPC: C07K16/28
Filed: 2021-12-17
Abstract: The present invention relates to bispecific antibodies which bind to human carcinoembryonic antigen CEACAM5 and human CD47. In addition, the present invention relates to polynucleotides encoding such bispecific antibodies and vectors and host cells comprising such polynucleotides. The invention further relates to methods for selecting and producing such antibodies and to methods of using such antibodies in the treatment of diseases. The invention also relates to the therapeutic use of the bispecific antibodies in monotherapy and in combination therapy.
Patent CA-3194081-A1 (CA)
Title: Detection et analyse de variations structurales dans des genomes
Inventor: SHOURA MASSA
IPC: C12Q1/6806
Filed: 2021-10-14
Abstract: L'invention concerne des compositions et des procédés pour la détection de loci dynamiques dans un génome. Les procédés peuvent faire appel à des plateformes microfluidiques et à des matrices polymères fonctionnalisées pour permettre la détermination de mécanismes d'hétérogénéité génomique programmée spécifique à un type de cellule.
Patent CA-3194197-A1 (CA)
Title: Polymer composite comprising oilseed meal
Inventor: LYNCH DANIEL ERIC
IPC: C08L67/04
Filed: 2021-09-29
Abstract: The invention concerns a polymer composite comprising: a. polymer in an amount of 5 - 94.5% by weight of the overall weight; b. milled oilseed meal in an amount of at least 5% by weight of the overall weight; c. plasticizer in an amount from 5 ? 50% w/w of component b); d. optional filler, and e. optional additive, wherein c) is a solid plasticizer with a melting temperature in the range of 70 to 210°. The invention also concerns a process for its preparation, an intermediate, and a solid article comprising the polymer composite.
Patent CA-3198652-A1 (CA)
Title: Leghemoglobine dans du soja
Inventor: CHO HYEON-JE
IPC: A01H6/54
Filed: 2021-10-22
Abstract: Selon l'invention, des plants de soja produisant des graines de soja comprenant de la léghémoglobine sont produits par modification du génome du plant de soja. L'invention concerne donc des plants de soja, des graines de soja et des compositions de protéines de soja comprenant de la léghémoglobine. L'invention concerne également des plants de soja, des graines de soja et des compositions de protéines de soja comprenant de la léghémoglobine et de plus un ou plusieurs parmi de l'acide oléique en une teneur élevée, de l'acide linolénique en une faible teneur, des protéines en une teneur élevée, du stachyose en une faible teneur, du raffinose en une faible teneur et/ou des inhibiteurs de protéases en une faible teneur. Des compositions de protéines comprenant de la léghémoglobine, telles que des isolats et concentrés de soja, peuvent être formées à partir des graines de soja. De plus, l'invention concerne des procédés de production et d'utilisation de plants, de graines et de compositions de protéines comprenant de la léghémoglobine.
Patent CA-3200189-A1 (CA)
Inventor: WEI JEFF
Filed: 2023-05-23
Abstract: The present disclosure generally relates to multi-stage digital converters, including multi-stage digital down-converters (DDCs) and multi-stage digital up-converters (DUCs). In at least one example, the multi-stage digital down converter (DDC) comprises a plurality of stages, each stage comprising a frequency mixer and a decimation filter, and at least one controller coupled to one or more of the plurality of stages and operable to control one of the frequency mixer and decimation filter. In another example, the multi-stage digital up converter (DUC) comprises a plurality of stages, each stage comprising a frequency mixer and interpolation filter; at least one controller coupled to one or more of the plurality of stages and operable to control one of the frequency mixer and the interpolation filter.
Patent CA-3201857-A1 (CA)
Title: Plantes ayant une resistance a la rouille noire
Inventor: MAGO ROHIT
IPC: C12Q1/6895
Filed: 2021-12-08
Abstract: La présente invention concerne une plante génétiquement modifiée qui a une résistance améliorée à un ou plusieurs pathogènes fongiques.
Patent CA-3204255-A1 (CA)
Inventor: XU LIANHONG
IPC: A61K31/7076
Filed: 2022-01-25
Abstract: La présente divulgation concerne des méthodes de traitement ou de prévention d'infections par des virus à ARN et de maladies rétrovirales, comme le VIH et le SIDA, comprenant l'administration à un sujet en ayant besoin d'une dose efficace (a) d'un inhibiteur de capside et (b) d'un dérivé d'adénosine selon la divulgation. Des compositions comprenant une dose efficace d'un dérivé d'adénosine et une dose efficace d'un inhibiteur de capside (CA) sont également décrites.
Patent CA-3204301-A1 (CA)
Inventor: HIRVI HANNU
IPC: H04L1/16
Filed: 2021-12-21
Abstract: L'invention concerne un système de communication sans fil (100) comprenant une pluralité de dispositifs radio (102, 202, 204). Chaque dispositif radio de la pluralité de dispositifs radio (102 202, 204) peut transmettre et recevoir des paquets de données (220). Au moins un dispositif radio (102, 202, 204) est configuré pour : observer des paquets ACK (240) reçus en provenance d'un ou de plusieurs dispositifs radio (102, 202, 204) voisins en réponse à des paquets de données transmis (220); déterminer des longueurs de périodes d'intervalle ACK (230) du ou des dispositifs radio (102, 202, 204) voisins sur la base des paquets ACK (240) observés; et ajuster sa durée d'écoute ACK (250) sur la base des longueurs déterminées des périodes d'intervalle ACK (230). L'invention concerne également un procédé pour un système de communication sans fil (100), un dispositif radio (102, 202, 204) pour un système de communication sans fil (100), un procédé pour le dispositif radio (102, 202, 204), un programme informatique (505) et un support tangible non volatil lisible par ordinateur.
Patent CA-3208078-A1 (CA)
Title: Data comparison method and apparatus, device and storage medium
Inventor: ZHOU JUCHENG
IPC: G06Q40/04
Filed: 2022-04-28
Abstract: Disclosed in the present application are a data comparison method and apparatus, a device and a storage medium. The method comprises: in response to a first operation of a user, receiving a stock comparison instruction; and displaying a stock comparison page, wherein the stock comparison page comprises a menu view and a row view corresponding to the menu view, the menu view comprises a stock name column and a data index selection list column, the data index selection list column comprises at least two data indexes, and each data index comprises at least one index; the row view corresponding to the stock name column comprises at least two first grid views, each first grid view is used for displaying a button for adding a stock to be compared or displaying a name and a deletion button of said stock, the row view corresponding to each index comprises at least two second grid views, and each second grid view is used for displaying data of each index of each stock to be compared. Therefore, data of a plurality of different indexes of a plurality of stocks can be displayed, and the stocks can be compared more comprehensively.
Patent CA-3210485-A1 (CA)
Title: Dynamic vehicle wheel balance apparatus, vehicle wheel, powered vehicle, and method for manufacture thereof
Inventor: MASON DOUGLAS P
IPC: B60B7/08
Filed: 2021-03-25
Abstract: A dynamic vehicle wheel balance apparatus, a vehicle wheel, a powered vehicle, and a related method for manufacture are provided. The dynamic vehicle wheel balance apparatus comprises a vehicle wheel cover and a dynamic vehicle wheel balance ring. The vehicle wheel cover comprises a first surface, a second surface, and a perimeter surface connecting the first surface to the second surface. The vehicle wheel cover is configured to removably attach to a flange of a vehicle wheel with the second surface opposing the vehicle wheel. The dynamic vehicle wheel balance ring is attached to the second surface of the vehicle wheel cover. The dynamic vehicle wheel balance apparatus dynamically balances the vehicle wheel during rotation of the vehicle wheel and reduces aerodynamic drag.
Patent CA-3211142-A1 (CA)
Title: Anti-muc1-c antibodies and car-t structures
Inventor: HARRIS KATHERINE
IPC: C07K16/30
Filed: 2022-02-28
Abstract: Anti-MUC1-C antibodies (e.g., UniAbsTM) and CAR-T structures are disclosed, along with methods of making such antibodies and CAR-T structures, compositions, including pharmaceutical compositions, comprising such antibodies and CAR-T structures, and their use to treat disorders that are characterized by the expression of MUC1-C.
Patent CA-3212214-A1 (CA)
Inventor: BLOMBERG FREDRIK GARDSTEIG
IPC: A61G5/14
Filed: 2022-03-22
Abstract: The present invention relates to the field of medical devices. In particular, the present invention relates to an apparatus (10) for assisting the movement of a subject, such as a patient or disabled person, to train and strengthen the muscles of their body, said apparatus (10).
Patent CA-3214657-A1 (CA)
Inventor: CURTIS DANIEL
IPC: A61K31/7084
Filed: 2022-03-24
Abstract: La microglie est une partie essentielle du système immunitaire dans le système nerveux central, ainsi que des sources potentielles de maladie. Le silençage génique utilise un petit ARN interférent (pARNi) pour cibler sélectivement des gènes qui sont la source de telles maladies. En utilisant un pARNi ramifié, la distribution du pARNi dans l'ensemble du SNC, y compris aux cellules microgliales résidentes, peut être améliorée par rapport à un pARNi non ramifié. L'invention concerne en outre des procédés et des compositions pour l'utilisation de pARNi ramifié dans une thérapie.
Patent CA-3215088-A1 (CA)
Inventor: HIDDESSEN AMY L
IPC: G01N35/00
Filed: 2011-11-01
Abstract: System, including methods, apparatus, and kits, for forming emulsions. The system may include an instrument and a microfluidic chip received by the instrument. The instrument may apply pressure to prospective emulsion phases held by the chip, to drive formation and collection of emulsions in the chip. In some embodiments, the instrument may stop applying pressure to the chip when a change in pressure meeting a predefined condition is detected by the instrument. The change may indicate that an endpoint of droplet generation has been reached.
Patent CA-3215114-A1 (CA)
Title: Agents ignifuges pour electrolytes de batterie
Inventor: VARNADO CHARLES DANIEL
IPC: H01M10/0525
Filed: 2022-03-31
Abstract: La présente invention concerne des solutions électrolytiques non aqueuses pour des batteries au lithium. Les solutions électrolytiques non aqueuses comprennent un milieu électrolytique liquide ; un sel contenant du lithium ; et au moins un ignifugeant bromé.