Patent AU-2007308749-B2 (AU)
Title: Retinal regeneration
Inventor: MARSHALL JOHN
IPC: A61F9/008
Filed: 2007-10-25
Granted: 2013-02-14
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date (10) International Publication Number 2 May 2008 (02.05.2008) WO 2008/049164 Al (51) International Patent Classification: (74) Agent: FISHER ADAMS KELLY; Level 29 Comalco A61F 9/008 (2006.01) Place, 12 Creek Street, Brisbane, Queensland 4000 (AU). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/AU2007/001622 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: 25 October 2007 (25.10.2007) AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CI, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, (25) Filing Language: English ES, FI, GB, GD, GE, GI, GM, GT, HN, HR, HU, ID, IL, (26) Publication Language: English IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, (30) Priority Data: LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, (3 090590) Pt Datr 2MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, 2006905904 25 October 2006 (25.10.2006) AU PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, (71) Applicant (for all designated States except US): ELLEX TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, MEDICAL PTY LTD [AU/AU]; 82 Gilbert Street, Ade- ZM, ZW. laide, South Australia 5000 (AU). (84) Designated States (unless otherwise indicated, for every (72) Inventors; and kind of regional protection available): ARIPO (BW, GI, (75) Inventors/Applicants (for US only): PLUNKETT, Mal- GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, colm [AU/AU]; 36 Lesley Crescent, Crafers, South Aus- ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), tralia 5152 (AU). HUSSAIN, Aly [GB/GB]; 101 Fern- European (AT, BE, BG, CI, CY, CZ, DE, DK, EE, ES, FI, dale Road, London SW4 7RL (GB). MARSHALL, John FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, [GB/GB]; Wildacre, 27 Cedar Road, Farnborough GU14 PT, RO, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, 7AU (GB). GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: RETINAL REGENERATION (57) Abstract: A method of retinal regeneration teration or death of RPE cells which improves retinal function by reversal of the Select retinal area for treatment n treatment zone degradation of the transport properties of Bruch's which does not have serious membrane. The method involves irradiation through damage Ithe cornea of the eye to the retinal pigmented othe prpher eof the treatment epithelium by a laser pulse or sequence of laser pulses Perform an intervention to alter zone are triggered into a migration having a pulse duration in the range of 10ps to 20ps or kill RPE cells by the applicatio response and at a wavelength in the range of about 500nm of short pulse radiation, without collateral damage to 900nm. The method applies a radiant exposure Production of enzymes, cytokines which results in the damaging or altering of the retinal and growth factors by the RPE pigmented epithelium cells in such a manner as to ove h ranse to cells to facilitate miration trigger cellular responses which improve the hydraulic Imprve Bruch's membrane transport function conductivity of Bruch's membrane without causing Extensive relocation of cells and irreversible damage to adjacent retinal structures and cascade release of enzymes, cytokines and growth factors. layers. Partial regeneration of Retinal function Increased levels of enzymes, cytokines and growth factors improves transport across Bruch's membrane Cell division completes the repair of the RPE cell layer Newly divided RPE cells contain Less waste and have improved function Retinal regeneration W O 2008/049164 A1l ||||||||||||||||||||||||||||||||||||||||||||||| Published: - with international search report