baber/WOPTO huggingface dataset:
Patent JP-2000512492-A (JP)
IPC: C12N15/09
Filed: 1997-05-19
Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular ligand-binding domain of a cell-surface receptor that is expressed at high levels in lymphoid tissues, including B-cells and T-cells. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of lymphoid and myeloid cells  in vitro  and  in vivo . Ligand-binding receptor polypeptides can also be used to block ligand activity  in vitro  and  in vivo .
Patent JP-2000511479-A (JP)
Title: タンパー指示多層シート
IPC: B32B7/12
Filed: 1997-05-20
Abstract: (57)【要約】
本発明は、可橈性バッキング（２）と、多層シートを平滑で堅い表面（５）へ付けるための感圧接着剤層（３）とを含む多層シート（１）であって、感圧接着剤は、表面（５）から容易に除去可能で、厚さ３００μｍで７０℃の温度で３日間保持した後のガラスからの９０°剥離接着力が２０から８５N/インチを示すように選択されている多層シート（１）に関する。可橈性バッキング（２）は、少なくとも１層の損傷可能な層（４）を含み、表面（５）から多層シート（１）を剥離するとき、層内破壊を示すのが好ましい。本発明はさらに、ａ）アルキル基が平均４から１４個のＣ原子を有する１種類以上のアルキルアクリレートと極性基を有する少なくとも１個の共重合可能なモノマー２から８ｐｈｒを含むモノマー成分と、ｂ）疎水性シリカ５から１５ｐｈｒと、ｃ）１種類以上の重合開始剤と、ｄ）参照架橋剤化合物としてヘキサンジオールジアクリレートを０．０６から０．１４ｐｈｒの濃度で用いて得られる架橋密度をもたらす濃度の１種類以上の架橋剤化合物とを含む前駆物質を重合することにより得られる感圧接着剤に関する。本発明はさらに、ａ）アルキル基が平均４から１４個のＣ原子を有する１種類以上のアルキルアクリレートと極性基を有する少なくとも１個の共重合可能なモノマー８から２０ｐｈｒを含むモノマー成分と、ｂ）疎水性シリカ５から１５ｐｈｒと、ｃ）１種類以上の重合開始剤と、ｄ）参照架橋剤化合物としてヘキサンジオールジアクリレートを０．０６から０．１１ｐｈｒの濃度で用いて得られる架橋密度をもたらす濃度の１種類以上の架橋剤化合物とを含む前駆物質を重合することにより得られる感圧接着剤に関する。
Patent MX-159295-A (MX)
Inventor: OWENS JOSEPH MICHAEL
IPC: C09G1/16
Filed: 1984-04-12
Abstract: This invention relates to polymer compositions which may be formulated into polishes especially floor polishes without requiring the use of additional leveling agents. These compositions are prepared by using, with polish polymer emulsions, polyalkoxylated linear aliphatic alcohols as leveling agents.
Patent NZ-195846-A (NZ)
Title: Rectally-administered drug compositions containing hydroxy-aryl or hydroxy-aralkyl acid derivatives as adjuvants
Inventor: NISHIHATA T
IPC: A61K9/02
Filed: 1980-12-16
Abstract: A drug form for enhancing the rate of absorption of a rectally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The drug form comprises a therapeutically effective dosage amount of a selected drug of the type which is capable of being absorbed into the blood stream from the rectal compartment and hydroxy aryl or hydroxy aralkyl acids or salts, amides or esters thereof, the hydroxy aryl or hydroxy aralkyl acids or salts, amides or esters thereof being present in the drug form in a sufficient amount to be effective in enhancing the drug absorption rate, when rectally administering the drug form to warm blooded animals.
Patent NZ-214892-A (NZ)
Title: Shelf-stable, paste-filled, shredded wheat biscuits
Inventor: LEIBFRED K J
IPC: A21D13/00
Filed: 1986-01-21
Abstract: The present invention provides a process for the continuous production of microbially shelf-stable paste-filled shredded cereal biscuits having an extended shelf-stable plurality of textures. A first plurality of net-like sheets of cereal dough are continuously laminated, followed by continuous depositing of at least one extrudate rope filling upon the first plurality of net-like sheets. A second plurality of net-like sheets is continuously laminated upon the at least one extrudate rope to obtain a filled laminate. Each of the net-like sheets has plurality of generally parallel longitudinal strands and a plurality of crosshatchings which are generally perpendicular to the longitudinal strands. The filled laminate is cut to enrobe the filling and the product is baked. The number of crosshatchings of the net-like sheets adjacent to the filling is greater than the number of crosshatchings of the net-like sheets which are further removed from the filling. The use of fewer crosshatchings provides a region of light texture which enhances the impression of a soft or chewy filling. The use of a greater number of crosshatchings in the net-like sheets which are adjacent to the filling: 1) prevents substantial penetration of the filling through the adjacent sheets during deposition of the extrudate rope and during baking, 2) enhances the chewiness of the filling, and 3)  reduces lateral movement of the longitudinal strands so as to facilitate consistent deposition of the filling rope in an at least substantially straight line. The region of light texture is preferably limited to the interior layers of the biscuit.
Patent NZ-221691-A (NZ)
Title: Milbemycin (ll-f28249) derivatives and parasiticidal compositions
Inventor: ASATO GORO
IPC: A01N43/90
Filed: 1987-09-07
Abstract: The present invention relates to novel derivatives of LL-F28249 compounds. These LL-F28249 compounds preferably are derived via a controlled microbiological fermentation of Streptomyces cyaneogriseus subsp. noncyanogenus having deposit accession number NRRL 15773. The 23-deoxy derivatives have the 23-hydroxy group replaced by hydrogen. The novel derivatives of the present invention possess activity as anthelmintic, ectoparasitic, insecticidal, acaricidal and nematicidal agents. They also are useful in areas of human and animal health and in agricultural crops.
Patent NZ-222639-A (NZ)
Title: Pyrrole-substituted acrylic acid derivatives and pesticidal, fungicidal and plant growth regulating compositions
Inventor: CLOUGH JOHN MARTIN
IPC: C07D207/337
Filed: 1987-11-20
Abstract: Compounds of formula: <CHEM> and stereoisomers and salts thereof, wherein R<1> and R<2>, which are the same or different, are optionally substituted alkyl; V is oxygen or sulphur; Y is hydrogen, optionally substituted alkyl, cyano, nitro or halogen; X is <CHEM>  CH2NR<1><0>R<1><1> or @- R<1><2>   Z is NOR<5> or @-B; A is CO2R<6>, COR<7>, cyano, nitro or acylamino; Bis hydrogen, optionally substituted alkyl, optionally substituted aryl, CO2R<8>, COR<9>, cyano, nitro or acylamino, or A and B together form a ring containing one or more heteroatoms; R<4> is CO2R<3> or R<1><7>; R<1><2> is OR<1><3>, SR<1><4>, NR<1><5>R<1><6> or R<1><8>; R<3> is optionally substituted alkyl; and R<5> to R<1><1> and R<1><3> to R<1><8>, which are the same or different, are hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aralkyl, optionally substituted aryl or optionally substituted heteroaryl, or R<1><0> and R<1><1> or R<1><5> and R<1><6> together with their adjacent nitrogen atom join to form a saturated ring (except that R<1><0> and R<1><1>, together with their adjacent nitrogen atom, do not form an unsubstituted piperidine ring when R<1> and R<2> are both methyl, Y is hydrogen and V is oxygen) optionally containing one or more heteroatoms in addition to the nitrogen atom. The compounds are useful as fungicides and also as plant growth regulators, insecticides, nematocides and miticides.
Patent NZ-226521-A (NZ)
Title: Method for increasing protein production in a cell culture by adding an inducer compound to the culture
Inventor: STECHER-SCHILLING ANDREA
IPC: C12N5/16
Filed: 1988-10-11
Abstract: A method for increasing the production of protein, especially t-PA, in cultures of cells producing this protein, where a substance which induces the production of the protein is added to the cell culture, is characterised in that thioglycolic acid, thiodiglycolic acid, L-cysteine, glutathione, butyrylcholine bromide, butyrylcholine chloride, nonactic acid, furan fatty acid, ascorbic acid, aphidicolin, 6-hydroxy-4,6-dimethyl-3-hepten-2-one, fusaric acid, mevalonic acid, trans-anhydromevalonic acid, anhydromevalonolactone, cis-anhydromevalonolactone, D- alpha -hydroxy-substituted (C3 or C4) aliphatic mono- or dicarboxylic acid or the salts thereof is used as protein-inducing substance.
Patent NZ-228784-A (NZ)
Title: Microcomputer with cache subsystem: selective posting of write cycles
Inventor: BEGUN RALPH MURRAY
IPC: G06F12/08
Filed: 1989-04-18
Abstract: A microcomputer system includes a microprocessor, a cache memroy, and a cache controller all coupled to a local bus. The local bus is coupled to a sytem bus, connecting the remaining system components, through latches. When writing data, the microcomputer can perform a posted write to a unit on the system bus by writing the data into the latches and then, on receipt of a ready signal from the cache controller, continuing its operations without waiting for the data to pas to its destination. A problem arises if the data is posted to a unit with a data width less than that of the microprocessor. In this case, the data should be sent in multiple cycles, but the read signal is generated before the data width of the unit is known and the microprocessor then continues its operations and can not, therefore, transmit the data correctly. To solve this problem, a logic unit is added to monitor the ready signal and the output of a decoder which detects non-cacheable addresses (which are of data width different from the microprocessor data width). If a non-cacheable address is detected, the read signal from the cache controller through the logic unit is withheld from the microprocessor, which now waits to continue processing beyond the write until a ready signal is received from the addressed unit on the system bus.
Patent NZ-229244-A (NZ)
Title: Process for creating an analog to botanic seeds using dehydrated meristematic tissue encapsulated in a hydrated gel
Inventor: REDENBAUGH M KEITH
IPC: A01N43/16
Filed: 1987-01-06
Abstract: Methods and materials are provided for desiccated analogs of botanic seeds which are created by removing a portion of the water by slow or fast drying so that the plant tissue is no longer saturated with water. In a second embodiment, the meristematic tissue is encapsulated in a gel or polymer followed by dehydration. In another embodiment, the meristematic tissue is dehydrated prior to encapsulation in a gel. Protectants can be incorporated in the gel capsule. Meristematic tissue can be isolated from, for example, somatic embryos, zygotic and germ line sources.
Patent NZ-231037-A (NZ)
Title: Anti-idiotypic monoclonal antibody of an antibody which binds to an epitope of a tumour-associated gp 72 protein, cell line and composition
Inventor: BALDWIN ROBERT WILLIAM
IPC: C12N5/20
Filed: 1989-10-17
Abstract: Novel compositions and methods are described for stimulating a patient's immune system to tumor cells which bear a gp72 tumor-associated antigen and thereby eliciting a tumoricidal effect. Anti-idiotypic human monoclonal antibodies and idiotopic regions thereof to primary antibodies which bind selectively to an antigenic determinant of gp72 are provided to mediate the humoral and cellular components of the patient's immune system. The immunogenic agents find use both in vivo and in vitro.
Patent NZ-234587-A (NZ)
Title: A chewable pharmaceutical tablet of compressed coated granules
Inventor: ROCHE EDWARD J
IPC: A61K9/00
Filed: 1990-07-19
Abstract: Chewable medicament tablets are made from coated rotogranules of a medicament wherein the rotogranules are formed from a granulation mixture of medicament, e.g. ibuprofen, polyvinylpyrrolidone and sodium lauryl sulfate and the rotogranules are coated with hydroxyethyl cellulose or a mixture of hydroxyethyl cellulose and hydroxypropyl methylcellulose and a process for making such tablets and a method of providing taste masking of medicaments utilizing such coated rotogranules in a tablet.
Patent NZ-276883-A (NZ)
Title: 1h-imidazol-4-yl)alkyl]benzene derivatives
Inventor: ASLANIAN ROBERT G
IPC: A61K31/415
Filed: 1994-11-10
Abstract: The invention provides novel phenyl-alkyl-imidazoles of the formula    <IMAGE>  I  wherein A, R1, R2, m and n are as defined in the specification, and the group -(CH2)n-A-R1 is at the 3- or 4-position, together with their pharmaceutically acceptable salts. These phenyl-alkyl-imidazoles and salts have valuable pharmacological properties, especially CNS activities and activity against inflammatory disease.
Patent NZ-281544-A (NZ)
Title: Paint roller: paint fed to roller by pump; paint flow rate controlled by sensing rotational speed of roller
Inventor: VAN OOST STEPHANE
IPC: B05C17/03
Filed: 1995-02-24
Abstract: PCT No. PCT/BE95/00018 Sec. 371 Date Aug. 23, 1996 Sec. 102(e) Date Aug. 23, 1996 PCT Filed Feb. 24, 1995 PCT Pub. No. WO95/23033 PCT Pub. Date Aug. 31, 1995A device for applying a liquid product, in particular paint, includes an applicator with at least one roller, a supply unit with a variable speed, volumetric pump, and a duct connecting the pump to the applicator. The pump is connected to a control unit. A detector detects a speed of the roller and provides a control signal corresponding to the speed to the control unit. The control unit includes a regulator for setting a linear relationship between the speed of the pump and the speed of the roller. The control unit controls the liquid product flow rate supplied by the pump based upon the control signal and the linear relationship set by the regulator.
Patent NZ-322113-A (NZ)
Title: Improved pseudocatalase composition
Inventor: SANDERS COLIN
IPC: A61K8/44
Filed: 1996-11-13
Abstract: PCT No. PCT/GB96/02758 Sec. 371 Date Apr. 16, 1998 Sec. 102(e) Date Apr. 16, 1998 PCT Filed Nov. 13, 1996 PCT Pub. No. WO97/17943 PCT Pub. Date May 22, 1997The in vivo catalytic dismutation of hydrogen peroxide by pseudocatalase such as a transition metal bicarbonate complex is increased by the addition of a chelating agent, preferably ethylenediaminetetraacetic acid (EDTA), citic acid, 2,6-pyridinedicarboxylic acid, or a salt thereof Further, the stability of a topical composition comprising a transition metal bicarbonate complex is improved by storing the composition under carbon dioxide, preferably under pressure in aerosol form.
Patent NZ-331262-A (NZ)
Title: Enzyme treatment to enhance wettability and absorbency of textiles
Inventor: HSIEH YOU-LO
IPC: C12S11/00
Filed: 1997-03-06
Abstract: method of altering water wettibility and absorbency in textile fibers without alkaline scouring or chemical oxidants, where the method comprises treating the fibers with an enzyme in an aqeuous medium being selected from pectinases, cellulases, proteases, and combinations thereof, and the medium is substantially free of surface active agents. Also claimed  is the aromatic polyester made by the above process.
Patent NZ-334984-A (NZ)
Title: Drying of organic material by freezing and slicing material before drying
Inventor: BALLANTYNE ANTHONY
IPC: A23L3/40
Filed: 1999-03-31
Abstract: A method for preparing a dried product of a natural substance, in particular deer antler, involves chilling an article of the substance to below 2°C so that the article becomes rigid, forming a series of partial incisions in the article whilst it remains chilled, and drying the partially incised article.  The drying step is preferably freeze-drying. The process enables the preservation and presentation of the article of natural substance in a seemingly natural state of colour, odour, and physical appearance, whilst allowing a small piece to be broken or cut from the larger product piece for sale to a consumer at the weakness of a partial incision.
Patent NZ-335010-A (NZ)
Title: Supporting frame for a manhole or similar access cover
Inventor: TRAVERS ALAN
IPC: E02D29/14
Filed: 1999-04-06
Abstract: support frame 3, for an access cover (e.g. an iron framework as illustrated), has an outer downwardly facing flange 6, an inner downwardly facing flange 5 and an upper web 7 connecting the outer to the inner flange.  The outer flange has at least one aperture and/or recess 12 which will allow concrete slurry to pass therethrough.  The frame member may be internally reinforced by internal webbing extending downwardly from the upper web and connecting at least a portion of the inner surface of the outer flange to at least a portion of the inner surface of the inner flange.  The upper web may have at least one aperture 9 which will allow concrete slurry to pass therethrough.
Patent NZ-336037-A (NZ)
Title: Stable highly active compositions of avidin with an inert support material (agar) a bulking agent and a protectant for separation
Inventor: BURTON STEVEN J
IPC: G01N33/532
Filed: 1996-10-28
Abstract: Stable, highly active compositions of avidin and an inert, easily separable support material, e.g., agarose, are disclosed.   The compositions may further include a bulking agent, e.g., maltose, and a protectant to maintain the stability and integrity of the avidin agarose during lyophilization and terminal sterilization processes.  The composition is in the form of a gel, slurry or suspension that comprises a liquid carrier, an inert support material on which the avidin is immobilized.  The composition has at least 50 units of biotin binding activity per milliliter.  The present compositions are useful in an enzyme capture system to prepare fibrin monomers which are useful for fibrin sealants.
Patent NZ-337693-A (NZ)
Title: Photodynamic therapy generated oxidative stress for temporal and selective expression of heterologous genes
Inventor: GOMER CHARLES J
IPC: A61K31/7088
Filed: 1998-03-09
Abstract: Methods to obtain selective and temporal expression of heterologous genes in target tissues. Promoters inducible by photodynamic therapy or heat are used to express genes of interest under conditions of heating or Photodynamic Therapy-(PDT-) induced oxidative stress. Selective and temporal expression of heterologous genes (such as cytokines, toxins, tumor suppressor genes, antisense molecules and anti-angiogenic factors) are of significant therapeutic benefit in the treatment of tumors, vascular proliferation and tissue hypertrophy. Gene therapy targeted by laser induced heating, other heating sources (such as microwave, ultrasound or radiofrequency induced currents), or PDT enhances treatment effectiveness by inducing expression of therapeutic genes in a controlled and localized manner.
Patent NZ-501920-A (NZ)
Title: Indole derivatives as MCP-1 receptor antagonists
Inventor: BARKER ANDREW JOHN
IPC: A61P9/00
Filed: 1998-08-04
Abstract: Compounds of the formula (I) wherein: R1 is independently selected from trifluoromethyl, C1-4 alkyl, halo, hydroxy, C1-4 alkoxy, C1-4 alkanoyl, C1-4 alkanoyloxy, amino, cyano, C1-4 alkylamino, di(C1-4 alkyl)amino, C1-4 alkanoylamino, nitro, carbamoyl, C1-4 alkoxycarbonyl, thiol, C1-4 alkylsulphanyl, C1-4 alkylsulphinyl, C1-4 alkylsulphonyl, sulphonamido, carbamoylC1-4 alkyl, N-(C1-4 alkyl)carbamoylC1-4 alkyl, N-(C1-4 alkyl)2carbarnoyl-C1-4 alkyl, hydroxyC1-4 alkyl, C1-4 alkoxyC1-4 alkyl, morpholino, pyrrolidinyl, carboxyC1-4alkylamino; R3 and -OR3 (where R3 is optionally substituted aryl or an optionally substituted 5- or 6-membered heteroaryl ring); p is 1-4 and R1 can have the same or different values when p is 2-4; T is of the formula: (CHR4)m-(SO2)-(CHR4)s-, (where R4 is independently selected from hydrogen or C1-4 alkyl, m=0-2, s=0-2, m+s=0-2, and R4 may take different values when m+s=2; X is carboxyl, tetrazol-5-yl, cyano, SO3H, -SO2NHR4 (where R4 is as defined above), -SO2 NHAr (where Ar is an optionally substituted phenyl or optionally substituted 5 or 6 membered heteroaryl ring), -CONHR5 (where R5 is cyano, OH, -SO2-C1-4alkyl, -SO2CF3, -SO2-phenyl, -(CHR4)r-COOH, (where r is 1-3 and R4 (as defined above) can take different values when r is 2-3)), or X is a group of formula (II) or X a group of formula (III) where the groups defined as R4 may have different values within the definition of R4 above; A is selected from phenyl, naphthyl, furyl, pyridyl and thienyl; R2 is independently selected from trifluoromethyl, C1-4alkyl, halo, hydroxy, trifluoromethoxy, cyano, C1-4 alkoxy, C1-4alkanoyl, C1-4alkanoyloxy, amino, C1-4alkylamino, di(C1-4alkyl)amino, C1-4alkanoylamino, nitro, carboxy, carbamoyl, C1-4alkoxycarbonyl, thiol, C1-4alkylsulphanyl, C1-4alkylsulphinyl, C1-4alkylsulphonyl, sulphonamido, carbamoylC1-4alkyl, N-(C1-4 alkyl)carbamoylC1-4alkyl, N-(C1-4alkyl)2carbamoyl-C1-4alkyl, hydroxyC1-4alkyl, C1-4alkoxyC1-4 alkyl or two R2 values together may form a divalent radical of the formula -O(CH2)1-4O- attached to adjacent carbon atoms on ring A; q is 1-4 and R2 may have the same or different values when q is 2-4; Z is hydrogen, fluoro, chloro, bromo, iodo, methyl, trifluoromethyl, hydroxymethyl, methoxy, methylsulphanyl, methylsulphinyl, methylsulphonyl or carboxyC3-6cycloalkyl, -(CHR4)n-NR6 R7 (where n is 0-2, R6 and R7 are independently selected from H and C1-4alkyl or R6 and R7 together with the nitrogen to which they are attached form a 5 or 6 membered non-aromatic ring optionally containing one further heteroatom selected from O, N or S); and wherein the term "C1-4alkyl" means straight chain, branched chain and cyclic groups of 1-4 carbon atoms; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof, with the proviso that the compounds 3-amino-4-phenoxy-1-tosylindole-2-carbonitrie and ethyl-5-bromo-1-tosylindole-2-carboxylate are excluded.
Patent NZ-505800-A (NZ)
Title: A multi-layer display and a method for extracting depth from 2D video data
Inventor: WITEHIRA PITA
IPC: G02B30/25
Filed: 1998-07-10
Abstract: A display comprising of multi-levels of screens, each screen being selectively transparent with the ability to display images. A method of defining screen layers for upon which to display image on by using sequential time based pixel change as a variable which defines layer.
Patent NZ-506976-A (NZ)
Title: Dual polarised multi-range antenna
Inventor: GOTTL MAXIMILIAN
IPC: H01Q5/42
Filed: 1999-05-20
Abstract: A dual-polarized multiband antenna includes first and second radiating element modules having first and second dipole elements. First dipole elements are positioned at right angles to one another to transmit and/or receive radiation in the first frequency band range with two linear orthogonal polarizations. The dipole elements form a dipole square. The second radiating element module transmits or receives radiation in a second frequency band range higher than the first frequency band range. The second module has dipole elements orthogonally related to one another and aligned parallel or at right angles to the first dipole elements. The second dipoles are arranged in a cruciform.
Patent NZ-510493-A (NZ)
Title: Pyrrolobenzodiazepin-5-one derivatives for treating viral, bacterial and protozoal infections
Inventor: THURSTON DAVID EDWIN
IPC: A61P31/00
Filed: 1999-08-27
Abstract: A pyrrolobenzodiazepine derivative has the formula Ia or Ib wherein: A is CH2 or a single bond; R2 is R, OH, OR, CO2H, CO2R, COH, COR, SO2R or CN; R6, R7 and R9 are independently H, R, OH, OR, halo, amino, NHR, nitro or Me3Sn; R is optionally substituted alkyl or an aralkyl group wherein the alkyl group optionally contains one or more carbon-carbon double or triple bonds, which may form part of a conjugated system, or an aryl group and optionally containing one or more hetero atoms which may form part of, or be, a functional group and R8 is H, R, OH, OR, halo, amino, NHR, nitro or Me3Sn or R7 and R8 together from a group -O-(CH2)p-O- and p is 1 or 2 or the compound is a dimer with each monomer being the same or different and being of formula Ia or Ib where the R8 groups of the monomers form together a bridge having the formula - X-R'-X- linking the monomers; R' is an alkylene chain which chain may be interrupted by one or more hetero-atoms and/or aromatic rings and may contain one or more carbon-carbon double or triple bonds; each X is independently O, S, or N; except that in a compound of formula Ia when A is a single bond, then R2 is not CH=CH(RARB) here RA and RB are independently H, RC, CORC, CONH2, CONHRC CONRC2, cyano or phosphonate, where RC is an unsubstituted alkyl group. A pyrrolobenzodiazepine derivative has the formula (II), (III) or (IV) wherein n is 1 to 7, R8' and R8" are independently H or R or together form a cyclic amine, R'2 is O or CH2 and R and R6 to R9 are as defined above. The compounds are useful in treating viral, parasitic or bacterial infections.