baber/WOPTO huggingface dataset:
Patent JP-2002166192-A (JP)
Title: Method for cleaning treatment of aqueous liquid for processing metal
Inventor: KONO MICHINOBU
IPC: B03B5/28
Filed: 2000-11-30
Abstract: PROBLEM TO BE SOLVED: To provide a method for the cleaning treatment of an aqueous liquid for a processing metal capable of removing a fine metal powder with a particle size of 5 μm or less in the aqueous liquid for processing the metal used in the processing of the metal without lowering the liquid characteristics of the aqueous liquid for processing. SOLUTION: The method for the cleaning treatment of the aqueous liquid for processing the used metal by the removal of the metal powder from the aqueous liquid for processing the metal, which contains micellar cut oil containing the metal powder generated by the cutting and/or grinding treatment of the metal, includes a cleaning stage wherein replenishing oil is added to the aqueous liquid and the resulting aqueous liquid is introduced into a centrifugal separator under such a condition that a micelle-unformed oil component containing the replenishing oil is present in the liquid in an amount of 0.5 mass % or more and the superfine metal powder with a particle size of <20 μm is removed along with the metal powder containing oil by a low speed centrifugal force not decomposing a micelle.
Patent JP-2002166471-A (JP)
Title: Aromatic polyamide film, method for manufacturing the same, and magnetic recording medium using aromatic polyamide film
Inventor: NAKAJIMA YUICHI
IPC: C08G69/12
Filed: 2000-12-01
Abstract: PROBLEM TO BE SOLVED: To provide an aromatic polyamide film having good slitting properties even if Young's modulus is large in TD, capable of being stretched in a high draw ratio and high in productivity. SOLUTION: The biaxially stretched aromatic polyamide film is characterized by that the thickness of the film is 2-5 μm, EMD+ETD>=25 GPa and ETD/EMD>=1.3 are satisfied when the Young's modulus in the longitudinal direction of the film is set to EMD and the Young's modulus in the lateral direction of the film is set to ETD and the rear angle in the longitudinal direction of the film is 20 # or less when the film is longitudinally torn.
Patent JP-2002173001-A (JP)
Title: Vehicle theft preventing device
Inventor: AKAMATSU KUNIO
IPC: E05B83/00
Filed: 2000-12-05
Abstract: PROBLEM TO BE SOLVED: To provide a vehicle theft preventing device decreased in number of components, portable, capable of saving storing space and simplifying setting, and having good crime prevention performance. SOLUTION: This vehicle theft preventing device is formed by a first wheel stop engagement body having a first engaging arm part engaged with an engaged part of the inside of a wheel at one end part of a fitting part, a second wheel stop engagement body having a second engaging arm part engaged with an engaged part of the outside of the wheel at a bar-like part slidably fitted to the fitting part of the first wheel stop engagement body to be elongated and contracted in the horizontal direction, and a lock device incorporated in a locking part provided on the first wheel stop engagement body for locking the first wheel stop engagement body and the second wheel stop engagement body from being elongated when the first and second engaging arm parts are set in the holding state inside and outside the wheel.
Patent JP-2002172059-A (JP)
Title: Electric pot
Inventor: TSURU TAKESHI
IPC: A47J27/21
Filed: 2000-12-06
Abstract: PROBLEM TO BE SOLVED: To provide an electric pot which is solved of problems that a harmful influence of blowing out high temperature steam of boiling water through a steam port and impossibility of obtaining rather warm water in a short time after boiling. SOLUTION: This electric pot is equipped with an inner vessel for boiling water, a heating means to heat the inner vessel, a hot water supply means to supply hot water in the inner vessel through a water supply passage, and a fan. Air blown by the fan is flowed toward the steam port to discharge the air together with steam during heating.
Patent JP-2002174636-A (JP)
Title: Device and method for measuring number and concentration of microorganism
Inventor: NAKAJIMA YUICHI
IPC: G01N33/569
Filed: 2000-12-08
Abstract: PROBLEM TO BE SOLVED: To provide a device for measuring the number and concentration of microorganisms capable of sensitively and automatically measuring the number of particular microorganisms in various samples with a simple structure. SOLUTION: This device has a reaction cell 3 capable of causing an antigen-antibody reaction in its interior by introducing a stable solution, a sample solution containing microorganisms having a predetermined antigenic determinant, and a test solution containing an antibody causing an antigen-antibody reaction with the antigenic determinant and bonded with a marker substance, a measurement cell 1 communicated with the interior of the reaction cell 3 by a communication passage 6 and provided with a migration electrode for dielectrically moving microorganisms reacted with the antibody and collecting them in an electric field concentrated part, a migration power source part 17 applying an alternating voltage to the migration electrode,  a measuring part 18 measuring concentration of the marker substance bonded with the microorganisms reacted with the antibody collected at the electric field concentrated part, a calculating part 19 calculating the number and/or concentration of the microorganisms from the concentration of the marker substance, and a control part 16 controlling the migration power source part, the measuring part, and the calculating part.
Patent JP-2002186154-A (JP)
Title: Grommet
Inventor: DOI AKIHIKO
IPC: H02G3/04
Filed: 2000-12-12
Abstract: PROBLEM TO BE SOLVED: To provide a grommet which enables the reduction of an inserting force, the improvement in sense of insertion, the increase of sticking force to a sitting hole, and the enhancement of workability using a simple constitutional change. SOLUTION: The grommet is composed of a grommet body 1, made of an elastic substance such as flexible resin, etc., and a locking member 2 made of resin to be fitted to the peripheral part of the grommet body 1. The grommet body 1 has a thick annular flange 11; an annular neck portion 12 which rises from the internal circumferential brim of the flange 11 in the axial direction; a small-diameter cylindrical portion 13 obliquely extending from the axial tip side of the neck portion 12; and a projecting portion 14, which is formed projecting in the radial direction in a uniting part of the small-diameter portion 13 to the neck portion 12 and has a diameter smaller than a fitting hole, and into its inside through hole 15, a wire harness is inserted.  The locking member 2 has semi circular split bodies 21a, 21b, a hinge 22 for connecting end of the split body 21a to one end of the split body 21b, a locking claw 23 and a locking claw coupling part 24 which constitute a lock mechanism for uniting the other ends the split bodies 21a, 21b. When the split substances 21a, 21b are locked, the locking member 2 as a whole becomes an annular body.
Patent JP-2002178526-A (JP)
Title: Ink jet printer
Inventor: HIRAOKA SHINICHIRO
IPC: B41J2/165
Filed: 2000-12-12
Abstract: PROBLEM TO BE SOLVED: To clean a line print head efficiently by a simple arrangement. SOLUTION: The ink jet printer comprises a line print head having a plurality of ink nozzles arranged along the direction of print line, a member for supporting the line print head on a rotary shaft extending in parallel with the arranging direction of ink nozzles, a drive section for rotating the line print head section about the rotary shaft by a specified angle from the print position, and a cleaning section facing the plurality of ink nozzles as the line print head rotates and cleaning the nozzles.
Patent JP-2001215766-A (JP)
Title: Method for recycling image forming device
Inventor: NAKAJIMA MASAO
IPC: G03G15/00
Filed: 2000-12-14
Abstract: PROBLEM TO BE SOLVED: To provide a method for recycling an image forming device by which the workability of recycling is improved by disassembling, selecting and reassem bling the recovered image forming device in every unit. SOLUTION: The acceptance inspection of a product 1 recovered after use in an acceptance stage 2 is performed to judge the validity on the recycling of the recovered product. The product to be recycled is fed to a disassembling and washing stage 3 and disassembled and separated into a main body frame, a unit consisting of plural parts, a single part and a part not to be recycled. The unit is recycled as it is, so that the adjustment of the respective parts and work are simplified. The main body frame, the unit and the single part, which are actually recycled, are selected in a part selection stage 4, inspected in an inspection and analysis stage 5 and fed to a production stage 6. In the production stage 6, the selected unit and single part are returned to the same main body frame as in disassembly, thereby assembling the image forming device.
Patent JP-2002184671-A (JP)
Title: Method and system for substrate treatment
Inventor: TATEYAMA MASANORI
IPC: H01L21/027
Filed: 2000-12-14
Abstract: PROBLEM TO BE SOLVED: To reduce influence on rate limiting due to other treatment parts. SOLUTION: The system consists of a load/unload part 2 which carries an untreated wafer into each treatment unit and unloads a treated wafer W from each of the treatment units, a sub-arm mechanism which is provided to each treatment unit accessibly, delivers a wafer W between it and the load/unload part 2 and carries a wafer W to each treatment unit one by one and a controller 13, which controls each part to carry out treatment by each treatment unit one by one by applying a maximum duration tn/m per unit, which is obtained by dividing the duration tn of each treatment unit by a number (m) of the treatment units as a single cycle, and sets a prewaiting time by a heat treatment system unit.
Patent JP-2001237261-A (JP)
Title: Semiconductor, device and method for manufacturing the same
Inventor: OBARA HIROSHI
IPC: H01L21/60
Filed: 2000-12-15
Abstract: PROBLEM TO BE SOLVED: To provide a highly reliable semiconductor device which can deal with bump electrodes of fine pitch, and a method for manufacturing the same. SOLUTION: The semiconductor device 100 comprises a pad member 12 having an electrical connection region 12a, an insulation layer 13 formed on the pad member 12, an underlying metal layer 14 formed on the pad member 12, and a bump electrode 15 provided on the underlying metal layer 14. The angle θ defined by the side face 15b of the bump electrode 15 and the surface of the pad member 12 is θ>=80 deg..
Patent JP-2001213345-A (JP)
Title: Automobile roll stability control
Inventor: BROWN TODD ALLEN
IPC: B62D101/00
Filed: 2000-12-19
Abstract: PROBLEM TO BE SOLVED: To provide a roll behavior stabilizing control system for a vehicle not depending on the turning state of the vehicle. SOLUTION: The roll behavior stabilizing control system 24 for an automobile has a plurality of sensors 28-37 for detecting the behavioral state of the vehicle, and a controller 26 for controlling brake pressure distribution to reduce tire moment, and makes the net moment of the vehicle reverse to a roll direction. The sensors include a speed sensor 30, a lateral acceleration sensor 32, a roll speed sensor 34 and a yaw rate sensor 28. The controller 26 is connected to the speed sensor 30, lateral acceleration sensor 32, roll speed sensor 34 and yaw rate sensor 28. The controller 26 determines a roll angle estimate in response to lateral acceleration, roll speed, vehicle speed and a yaw rate. The controller 26 changes a tire force vector 22 with the change of a steering angle in response to the relative roll angle estimate.
Patent JP-2002188772-A (JP)
Title: Method of inserting lock ring for release prevention joint
Inventor: ARAKAWA NORIYUKI
IPC: F16L1/024
Filed: 2000-12-22
Abstract: PROBLEM TO BE SOLVED: To easily perform an insertion when a lock ring is inserted from the outer face of a socket into a storage groove in the inner surface of the socket through a through hole. SOLUTION: In this method of inserting the lock ring for the release prevention joint having a lock ring member 3a inserted from the outer face of the socket 1 into the lock ring storage groove 2 in the inner surface of the socket 1 through the through hole 7, the lock ring member 3a curvedly formed in a C-shape is forcibly inserted from one end by a moving element 19 reciprocating along the insert direction of the lock rig, an extension member 23 of the length for supplementing a distance L between the moving element 19 and the through hole 7 is connected to the lock ring member terminal 3b in a final terminal portion 3b, the lock ring member 3a is fully inserted into the storage groove 2, and lastly the extension member 23 is removed.
Patent JP-2002187203-A (JP)
Title: Production method for biaxially stretched polyamide film
Inventor: HARUTA MASAYUKI
IPC: B29C55/12
Filed: 2000-12-22
Abstract: PROBLEM TO BE SOLVED: To provide a production method for a biaxially stretched polyamide film having an excellent dimensional stability and less deviation of physical property in width-direction. SOLUTION: At stretching in longitudinal direction, a position in width- direction where a film thickness is more than 1.1 times of the central position is heated by this method.
Patent JP-2002195929-A (JP)
Title: Dust sensor and air cleaner using the same
Inventor: MATSUI YASUNORI
IPC: B01D46/42
Filed: 2000-12-25
Abstract: PROBLEM TO BE SOLVED: To provide a dust sensor small in size and low in cost capable of measuring the diameter of particle of dust and discriminating the dust from smoke. SOLUTION: The dust sensor optically detects the amount of dust by emitting light from a light source 1 and detecting the scattered light using a photodetector 2. The diameter of particle of the dust is detected on the basis of a period during which the photodetector 2 outputs continuously. The continuous period of the output is varied due to the difference between the particles in diameter, thereby measures the diameter of particle of the dust from the continuous period of the output.
Patent JP-2002195439-A (JP)
Title: Solenoid valve device
Inventor: HARIO TETSUO
IPC: F16K31/06
Filed: 2000-12-26
Abstract: PROBLEM TO BE SOLVED: To provide a solenoid valve device preventing a change of flow control characteristics and a defective operation with a simple structure. SOLUTION: An adjuster pipe 50 is screwed to the inner peripheral side of a fixed core 21 to adjust the energizing force of a spring. The male screw section 51 of the adjuster pipe 50 is screwed to a female screw section 210 formed on the inner peripheral side of the side core 21. Rib sections 52 extending in the axial direction are formed at a plurality of positions in the peripheral direction on the male screw section 51. Since the rib sections 52 are the incomplete screw sections of the male screw section 51, they are threaded by the female screw section 210 when they are screwed to the inner peripheral side of the fixed core 21, thereby the female screw section 210 and the rib sections 52 are meshed with each other, and a backlash caused by the play of the screw sections is prevented without applying an adhesive and seal agent.  A change of flow control characteristics caused by the change of the energizing force of the spring due to the backlash can be prevented, and the defective operation caused by the infiltration of a seal member 53 can be prevented.
Patent JP-2002193611-A (JP)
Title: Apparatus for producing crystal silicon
Inventor: SASAKI JUNICHI
IPC: C30B29/06
Filed: 2000-12-26
Abstract: PROBLEM TO BE SOLVED: To achieve reduction of deposits in the interior of a chamber outside a surrounding furnace. SOLUTION: The apparatus 1 for producing a crystal silicon is provided with a chamber 2 which has a die 4 to accommodate a molten material 3, a surrounding furnace 6 to surround the die 4, heating means 7a, 7b to generate the molten material 3 by heating the silicon material 3a which is accommodated in the die 4, and a plurality of through holes 23, 24, 25 to penetrate the surrounding furnace 6. A partition wall 30 is provided such that the interior of chamber 2 outside the surrounding furnace 6 is separated corresponding to each through hole 23, 24, 25.
Patent JP-2002153324-A (JP)
Title: Portable electric shoe shiner
Inventor: NOMURA REIKO
IPC: A46B13/02
Filed: 2000-11-21
Abstract: PROBLEM TO BE SOLVED: To provide a portable and convenient shoe shiner capable of shining shoes easily as a brush automatically rotates when it is held by hand and switched on. SOLUTION: This portable and electric shoe shiner constitutes its characteristic feature of providing a small motor 2 on an upper part of a main body 1 and installing the rotary brush 4 on a motor shaft 3.
Patent JP-2002195209-A (JP)
Title: Hydraulic cylinder holding device for hydraulic closed circuit
Inventor: OSUGA TADAO
IPC: F15B11/08
Filed: 2000-12-27
Abstract: PROBLEM TO BE SOLVED: To smoothly actuate a hydraulic cylinder device on no impact by reliably holding a hydraulic cylinder driven in a hydraulic closed circuit when the hydraulic cylinder device starts and stops. SOLUTION: A pump discharges pressure oil when the hydraulic cylinder device 11, which is stopping, is actuated. The internal pressure of a third passage 24 and a forth passage 25 is equal to that of a first passage 12 and a second passage 13, and then a selector valve 30 is selected from the closed position 30a to the open position 30b. The pump lowers a number of revolutions to a micro number of revolutions when the hydraulic cylinder device 11, which is activating, is stopped. Then, the selector valve 30 is selected from the open position 30b to the closed position 30a.
Patent JP-2002199637-A (JP)
Title: Motor
Inventor: HASHIMOTO NORIETSU
IPC: H02K37/04
Filed: 2000-12-27
Abstract: PROBLEM TO BE SOLVED: To provide a motor of which the subsystem winding does not cause a short circuit even the main system winding causes a layer short circuit or the like. SOLUTION: The motor has a rotor 12 disposed rotatably and a stator 20 enveloping the rotor 12, and two windings of the main system winding 25 and the subsystem winding 26 is wound on the stator 20. A main system winding part 22A and a subsystem winding part 22B which are exclusive use for the main system winding 25 and the subsystem winding 26, respectively, are provided on each stator pole 22, and the main system winding is wound on the main system winding part 22A and the subsystem winding 26 is wound on the subsystem winding part 22B, respectively and separately.
Patent JP-2002192344-A (JP)
Title: Monitoring method of weaving in arc welding and its apparatus
Inventor: KAWAGOE TEI
IPC: B23K9/127
Filed: 2000-12-27
Abstract: PROBLEM TO BE SOLVED: To provide a monitoring method of weaving and its apparatus capable of detecting a moving amount of arc welding that moves by means of weaving of a welding torch. SOLUTION: CCD camera having a suitable filter in the monitoring method of weaving and its apparatus regarding arc welding is provided, and welding arc is photographed while synchronized with weaving of welding torch, that is, both of moving edges of reciprocating welding torch. Based on the photographed image of the welding arc, a center of balance of the image itself of the welding arc is calculated, and a moving range of the welding arc can be detected from the calculated result. Consequently, these signals can be outputted to a control apparatus after the range of the welding arc is judged whether it is correct or not.
Patent JP-2004053250-A (JP)
Title: Emission timing detecting method, emission timing detecting apparatus, and rangefinder
Inventor: INABA NAOTO
IPC: G01S17/10
Filed: 2000-12-27
Abstract: <P>PROBLEM TO BE SOLVED: To accurately detect the timing of light irradiation of prescribed optical power from a light emitting element.  <P>SOLUTION: This laser rangefinder 100 takes the emission timing of a semiconductor laser 112 as the timing at which a voltage V impressed on the semiconductor laser 112 reaches a predetermined voltage (VTH-VF1), and takes the predetermined voltage (VTH-VF1) as a voltage at which the prescribed optical power P0 is outputted from the semiconductor laser 112.  <P>COPYRIGHT: (C)2004,JPO
Patent JP-2001513467-A (JP)
Title: 車輌用の操縦コラム組立体
IPC: B62D1/19
Filed: 1998-08-05
Abstract: (57)【要約】
操縦コラム軸（３ａ、３ｂ）が２つの部分から成る操縦コラムハウジング内に支持されたエネルギ吸収操縦コラム組立体が開示されている。２つの部分から成るハウジングは、車体に固着された第一の部分（１）と、該第一の部分（１）により支持され且つ事故時、第一の部分に対し伸縮式に摺動し得るようにされた第二の部分（２）とを備えている。２つの部分間の空間内にばね（５）が設けられ、第一の部分（１）と第二の部分（２）とが相対的に移動したとき、該ばね（５）が２つの部分の少なくとも一方に沿って摺動し、減衰効果を提供する摩擦力を発生させる。また、２つの部分から成るハウジング（１、２）がエネルギ制御機構（３００、４００）を通じて車輌に固着され、該エネルギ制御機構が、第二の部分の開口部に沿って又は該開口部を通じて「押圧的に通過する」第一の部分を備える、追加的な別個の実施の形態も開示されている。第一の部分が第二の部分の開口部を通過するとき、その断面積を変化させることにより、所定の減衰力を発生させることが可能となる。
Patent JP-2001520248-A (JP)
Title: 熱可塑性ポリマーアロイ組成物
IPC: D06N3/00
Filed: 1998-10-09
Abstract: (57)【要約】
エチレン／アクリル酸アルキル（またはメタクリル酸アルキル）を、ポリプロピレン、エチレン共重合体イオノマー樹脂、エチレン／アクリル酸グリシジルまたはメタクリル酸グリシジルの共重合体、および架橋されていないエチレンプロピレンゴムの配合物と配合することにより作成されるカレンダー仕上可能な熱可塑性ポリマーアロイ組成物。
Patent JP-2001522601-A (JP)
IPC: C12N15/09
Filed: 1998-11-11
Abstract: A nuclear delivery construct comprises (i) protein H or a fragment or derivative thereof that is capable of being targeted to the nucleus of a eukaryotic cell; and associated therewith (ii) one or more other components whose targeting to the nucleus of the eukaryotic cell is desired.
Patent JP-2001523865-A (JP)
Title: コンピュータネットワークにおけるアプリケーションプログラムの制御された配信
IPC: G06F13/00
Filed: 1998-11-06
Abstract: (57)【要約】
インターネット又はイントラネット環境（１２）において、多数のクライアント（例えばウェブブラウザ）をサポートするプロクシサーバ又はルータ又はインテリジェントスイッチ又はファイヤウォール（１４）が、クライアントの特性に応じて、特定のクライアント（１８）にソフトウェアモジュール（２０）を配信することが可能な追加の機能を有する。ダウンロードされた前記モジュール（２０）は、次に該クライアント（１８）によって実行され、これによりプロクシサーバ（１４）と該クライアント（１８）の間の双方向通信リンクがセットアップされる。この双方向リンクによって、クライアント（１８）側において、クライアントのプラットフォーム上のウインドウを用いて、例えばプロクシサーバ（１４）の動作の現在状態、例えばウイルススキャニング、コンテンツフィルタリング、帯域幅使用量等を示す状態表示が可能となる。別の用途では、ダウンロードされたモジュール（２０）により、掲示板、ニュースチャンネル、又は共通のソフトウェアパッチのプロバイダを提供することができる。
Patent JP-2001525607-A (JP)
Title: 変圧器
IPC: H01F27/28
Filed: 1998-11-30
Abstract: (57)【要約】
少なくとも１つの高圧巻線（３２）と１つの低圧巻線（３２）とを有する電力変圧器。各巻線は少なくとも１つの電流搬送導体と、前記導体の周りに配置された半導電特性を有する第１層と、前記第１層の周りに配置されたソリッド絶縁層と、前記絶縁層の周りに配置された半導電特性を有する第２層とを含む。前記巻線は、高圧巻線が低圧巻線と混合するように相互に交錯される。
Patent JP-2002501823-A (JP)
IPC: B01D53/26
Filed: 1999-01-21
Abstract: The invention concerns a method for purifying a gas consisting of acid compounds which consists in subjecting the gas to a dry or semi-wet treatment with a basic reagent comprising an anhydrous sodium carbonate powder, with specific surface area greater more than 2 m<2>/g, which while it is being handled, is maintained in an atmosphere with relative humidity less than 20 % and/or to which a desiccant has been added.
Patent JP-2002501764-A (JP)
Title: 脱脂乳粉末代用品
IPC: A23C9/15
Filed: 1999-02-03
Abstract: (57)【要約】
【課題】  脱脂乳粉末代用品を提供する。
【解決手段】  タンパク質ならびに非発酵性甘味料および／または充填剤の均質な混和物からなる脱脂乳粉末代用品を提供する。該粉末には、タンパク質１００重量部に対してラクトース０ないし４０重量部および脂肪０ないし１０重量部が含まれる。該粉末は、タンパク質ならびに甘味料／充填剤を含む成分の水溶液または分散体の形成により、続く乾燥、例えば噴霧乾燥により製造される。脱脂乳粉末代用品は、食品、特にチョコレート製造における成分として有効である。
Patent JP-2002502632-A (JP)
Title: 傾斜した毛管開口を備えている通気性バックシートを有する吸収体
IPC: A61F13/15
Filed: 1999-02-03
Abstract: (57)【要約】
本発明は、吸収体、生理用ナプキン又はパンティーライナー、大人の失禁用製品、汗取りパッド、バストパッド、そして特に赤ちゃん用おむつのような吸収体に関係しており、使用中に装着者に対面している表面上に繊維質の織布又は不織布トップシートを有する。本発明に従えば、これらの吸収体にはまた、通気性のための開口バックシートも備えられている。バックシートは、開口を有している一体式ポリマーフィルムから成る弾性三次元ウエブの少なくとも１つの通気層を備えている。これらの開口は、フィルムの平面に対し垂直でなく、フィルムの平面に対して９０°未満の角度に配置されている毛管を形成する。
Patent JP-2002534353-A (JP)
Title: 高脂血症の遺伝子治療のための方法および化合物
IPC: C12N15/11
Filed: 1998-08-28
Abstract: (57)【要約】
本発明は、3種類のアポリポタンパク質Apo A1、Apo BおよびApo Eをコードする遺伝子に特定の変異を導入することに関する。Apo A1の改変は、ジスルフィド架橋されたApo A1ホモ二量体およびApo A1/A2ヘテロ二量体が形成されるようにシステイン残基を導入するものである。Apo Bの改変は、トランケートされたApoBタンパク質を生成させる停止コドンまたはフレームシフト突然変異を導入するものである。Apo Eの改変は、防御的として同定されている特定の点突然変異を導入するものである。被験者の肝臓においてこれらの改変型タンパク質を産生させると、アテローム性動脈硬化を発症する被験者のリスクが減少する。ある実施形態においては、遺伝子の変異がキメラな混合RNA/DNA二本鎖オリゴヌクレオチドの使用により導入される。