baber/WOPTO huggingface dataset:
Patent AP-1590-A (AP)
Title: Human monoclonal antibodies to CTLA-4.
Inventor: HANSON DOUGLAS CHARLES
IPC: A61P35/00
Filed: 1999-12-23
Granted: 2006-03-14
Abstract: In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRS), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.
Patent DO-P2007000022-A (DO)
Title: Derivados de n-heteroaril-carboxamidas tricíclicas que contienen un resto bencimidazol, su preparación y su aplicación en terapéutica
Inventor: DUBOIS LAURENT
Filed: 2007-02-01
Abstract: La invención se refiere a derivados de N-heteroaril-carboxamidas tricíclicos que contienen un resto bencimidazol, de fórmula general (I) en la que A junto con el enlace C-N del resto de bencimidazol al que está condensado, representa un heterociclo monocíclico o un heteroarilo monocíclico de 4 a 7 eslabones, que contiene de 1 a 3 heteroátomos elegidos entre O, S o N, incluido el átomo de nitrógeno del resto de bencimidazol; P representa un heterociclo bicíclico o heteroarilo bicíclico de 8, 9, 10 u 11 eslabones, que comprende de 1 a 6 heteroátomos seleccionados entre N, O y S ; R1 representa de 1 a 4 átomos o grupos iguales o diferentes; Y r epresenta un átomo de oxígeno o azufre;R2 representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C1 C6, cicloalquilo C3 C7, cicloalquil(C3 C7)-alquileno(C1-C3), fluoroalquilo C1 C6 o alcoxi C1 C6; R3 representa de 1 a 3 átomos o grupos iguales o diferentes; en el estado de base o de sal de adición de ácido, así como en el estado de hidrato o de solvato. La invención también se refiere a un procedimiento para prepara los compuestos y su aplicación en tratamientos terapéuticos.
Patent DO-P2015000022-A (DO)
Title: 2,3-benzodiacepinas
Inventor: KUHNKE JOACHIM
IPC: C07D417/10
Filed: 2015-02-06
Abstract: Lo que se describe son 2,3-benzodiacepinas inhibidoras de proteínas BET, en particular inhibidoras de BRD4 de fórmula general (I) en las que R1a, R1b, R1c, R2, R3, R4, R5, A y X tienen los significados dados en la descripción, los intermedios para preparar los compuestos de acuerdo con la invención, composiciones farmacéuticas que comprenden a los compuestos de acuerdo con la invención y su uso profiláctico y terapéutico para trastornos hiperproliferativos, en particular, para trastornos tumorales. También se describe el uso de inhibidores de proteína BET para hiperplasias benignas, trastornos ateroescleróticos, septicemia, trastornos autoinmunes, trastornos vasculares, infecciones virales, para trastornos neurodegenerativos, para trastornos inflamatorios, para trastornos ateroescleróticos y para el control de la fertilidad masculina.
Patent DO-P2016000094-A (DO)
Title: Compuestos derivados de piridilo bicíclicos fusionados a anillo como inhibidores de fgfr4.
Inventor: FAIRHURST ROBIN ALEC
IPC: C07D519/00
Filed: 2016-04-25
Abstract: LA PRESENTE INVENCIÓN PROPORCIONA UN COMPUESTO DE LA FÓRMULA (I) O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO; FÓRMULA (I) UN MÉTODO PARA FABRICAR DICHO COMPUESTO, Y SUS USOS TERAPÉUTICOS. LA PRESENTE INVENCIÓN ADEMÁS PROPORCIONA UNA COMBINACIÓN DE AGENTES FARMACOLÓGICAMENTE ACTIVOS Y UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE DICHO COMPUESTO.
Patent DO-P2016000322-A (DO)
Title: N-(cianometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida
Inventor: WANG FANG
IPC: C07D239/42
Filed: 2016-12-05
Abstract: La presente invención se refiere a formas de sales nuevas y estables de N-(cianometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida que son adecuadas para la preparación de formulaciones farmacéuticas de las mismas y su uso terapéutico.
Patent DO-P2019000063-A (DO)
Title: Aparato de entrada de caracteres
Inventor: GYU HONG LEE
IPC: G10L13/08
Filed: 2019-03-14
Abstract: La presente invención se refiere a un aparato de entrada de caracteres que comprende: una unidad de entrada de caracteres para introducir un carácter y una unidad de representación de caracteres para representar el carácter introducido en una pantalla. El aparato de entrada de caracteres consiste en una o más unidades de entrada de caracteres ensambladas por una unidad de un carácter introducido, se divide en una unidad de entrada de idioma para introducir una entrada de un carácter de idioma y una unidad de entrada miscelánea en términos de una función y dividirse en una parte de entrada de caracteres derecha, parte de entrada de caracteres izquierda, parte de entrada de caracteres superior, parte de entrada de caracteres inferior y parte de entrada de caracteres central en términos de una disposición que permite una introducción simultánea de caracteres de dos o más idiomas, y dos o más unidades de entrada de idioma y una o más unidades de entrada misceláneas están en todo momento dispuestas en la unidad de entrada de caracteres y los caracteres de una pluralidad de idiomas están en todo momento mostrados en la unidad de entrada de caracteres para introducir simultáneamente los caracteres de dos o más idiomas sin una operación de conversión de idioma.
Patent EC-SP11011288-A (EC)
Title: Derivados de indol como antagonistas del receptor crth2
Inventor: BERTHELETTE CARL
IPC: A61K31/405
Filed: 2011-08-24
Abstract: La presente invención proporciona nuevos compuestos que son antagonistas del receptor CRTH2. Los compuestos de la presente invención son útiles para el tratamiento de diversas enfermedades y trastornos mediados por prostaglandina; por consiguiente, la presente invención proporciona un método para el tratamiento de enfermedades mediadas por prostaglandina que usa los compuestos novedosos que se describen en este documento, así como composiciones farmacéuticas que los contienen.
Patent EE-200200072-A (EE)
Inventor: EUSTACE PAUL
IPC: B29C48/03
Filed: 2000-08-16
Abstract: Methods of making articles are described comprising the steps of applying a capstock material over a layer of a substrate material and then calendaring said capstock material and said substrate material with calendaring rolls to form an article, wherein said capstock material contacts said calendar rolls for a shorter period of time than said substrate material. The capstock material comprises a melt-processable thermoplastic composition comprising a) 50-99.5 wt. % of a melt-processable thermoplastic polymer and b) 0.5-50 wt. % of a particulate polymer comprising the residues of a monomer mixture comprising 50-100 wt. % of MMA, at least 0-50 % of an ethylenically unsaturated comonomer comprising at least one alkyl acrylate or methacrylate and 0-10 wt. % of a copolymerisable cross-linking monomer said particles having a maximum dimension of 5 mm.
Patent EE-200300590-A (EE)
Inventor: LORENTZEN LENA LANDIN
IPC: A47F1/02
Filed: 2002-05-27
Abstract: Collection device including a container (3), which is provided with a pick part (5) arranged with a lid (4) for the access of commodities placed in the container as well as a refilling part (6) arranged to enable refilling of the commodities, the container (3) furthermore being provided with a number of through bottom holes (8) as well as a detachable waste box (10) placed vertically below the bottom holes that enables a collection of waste of commodity falling down through the bottom holes (8).
Patent EG-23352-A (EG)
Title: Ladle equipped with gas-blowing device having accumulator cylinder.
Inventor: KEIZO ARAMAKI
IPC: C21C7/072
Filed: 2002-12-29
Granted: 2005-01-31
Abstract: A ladle (1) equipped with a gas blowing device having an accumulator cylinder (7) is provided, which has the capability of suppressing molten metal from penetrating into an injection plug (3) embedded in the ladle (1) and having a high resistance leading to a longer service life of the injection plug (3). The gas-blowing device (5) comprises a main pipe (8) for blowing gas into the ladle (1) via a gas-blowing plug (3) from a positionally independent gas supply source (4); an accumulator cylinder (7) for accumulating the gas supplied through the main pipe (8); and a controller (6). The controller (6) is used for accumulating the gas into the accumulator cylinder (7) when the gas blowing through the main pipe (8) begins or when the gas blowing is carried out, and for starting to blow the gas accumulated in the accumulator cylinder (7) simultaneously with a termination of the gas blowing through the main pipe (8). <IMAGE>
Patent GB-189314841-A (GB)
Title: Improvements in Corset Back Fastenings.
Inventor: LINDAUER SIGMUND
Filed: 1893-08-02
Granted: 1893-09-30
Abstract: 14,841. Campbell, J. July 6. Sawing.-Relates to an adjustable guard for circular saws. The horizontal axis E, on which the guard is supported, is clamped to a slide D, which can be raised or lowered on the pedestal A by a screw C. The front guard L is made to slide in the boss L<1> so as to rise when pressed upon by the advancing wood ; it may also be clamped in the raised position by a set-screw 8. The boss L<1> is mounted on the end of two rods H, H<1>, which slide in a boss X capable of turning on the end of the rod E, the rods H, H<1> being kept horizontal by stop 5. A riving-knife K can be clamped in any required position on the rods H, H<1>. To get access to the saw, the whole guard may be turned back on the axis E, as shown by the arrow.
Patent GB-189703120-A (GB)
Title: Improvements in Incandescent Electric Lamps and their Connections or Holders.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1897-02-05
Granted: 1898-02-05
Abstract: 3120. Thompson, W. P., [Pope, F. R.]. Feb. 5. Incandescent lamps.- The necks of bulbs are formed with irregularities of any kind, to engage with corresponding irregularities in caps, in such a way that the weight of the lamp cannot detach it from the cap. The bulb is preferably further secured by solder, but without plaster, so that a spoilt lamp may be separated from its cap, repaired, and replaced. Specification No. 2343, A.D. 1895, is referred to. In the bulb shown, one or more bayonet grooves A are moulded in the glass of the neck, to engage studs fixed in the cap ; when so engaged, solder or other suitable substance is introduced through a hole in the cap into one of the grooves A. In other constructions, the grooves A are slanted, or the bulb neck is screwed, or carries the studs, or is made with depressions which receive the ends of tongues, stamped in from the cap, or receive buttons projecting through holes in the cap from a spring or band. This may extend half round the cap and be soldered or sprung on ; or metal or wire fused into the glass of the bulb may engage holes in the cap. The Provisional Specification mentions the use of solder alone, placed in holes in the cap, and depressions in the glass.
Patent GB-189705861-A (GB)
Title: Improvements in Balanced Slide Valves.
Inventor: BAXTER PETER MACLEOD
Filed: 1897-03-05
Granted: 1898-02-12
Abstract: 5861. Baxter, P. MacL. March 5. Valves, distributing.-Comprises various forms of balanced slide valves in which the valve, or combination of two valves (one for each end of the cylinder), is furnished with two relief frames or rings. Fig. 1 shows, in section, an engine cylinder with a valve A, A' of this kind, and Fig. 2 a plan of the back of the valve. One face of the valve works against the cylinder port face, and the other, bearing the relief rings D, is in contact with the cover. The cavity extends through the valve from one face to the other, and the valve-chest cover is formed with a steam inlet passage 1. In other Figures are shown examples of valves, or sets of valves, suitable for different forms of twocylinder high-pressure and compound engines.
Patent GB-189710794-A (GB)
Title: Improvements relating to Teats or Nipples for Feeding Bottles.
Inventor: CONTANT LOUIS
Filed: 1897-04-30
Granted: 1898-03-05
Abstract: 10,794. Contant, L. April 30. Feeding-bottles.-The teat g is secured by its bead f in the groove e in the funnel-shaped tubular stopper a, the stem b of the stopper being provided with a washer c which fits in the mouth of the bottle. The washer is also fitted with a re movable tube d, which serves for the admission of air as the bottle is emptied. The teat g collapses slightly as the bottle becomes empty, so that the infant has a soft surface in contact with its lips. The teat can be detached from the groove e to facilitate cleaning.
Patent GB-189711434-A (GB)
Title: Apparatus for Teaching Reading and Reckoning.
Inventor: GINDLER FRITZ
Filed: 1897-05-07
Granted: 1897-07-10
Abstract: 11,434. Gindler, F., and Kuhne, H. May 7. Reading and arithmetic, teaching.-Reading is taught by means of a series of cards b sliding in grooves d in boxes c. Each card is marked with a letter or syllable, so that, by raising the cards, words can be built up. The appliance may be used for teaching languages. Instead of sliding in grooves the cards may be held between spring- pressed blocks. A modified form of apparatus having rods or pins in place of cards is used for teaching arithmetic.
Patent GB-189712984-A (GB)
Title: Improvements in connection with the Purification of Sewage and Polluted Water.
Inventor: CANDY FRANK PULLEN
Filed: 1897-05-27
Granted: 1898-05-27
Abstract: 12,984. Candy, F. P. May 27. Sewage filters.-An apparatus for automatically controlling the flow of sewage and foul water to or from a pair of filter beds comprises a vessel 1 provided with valves 4, 5 and discharge pipes 2, 3, respectively connected to the filter beds, which are respectively connected by means of pipes 21, 22 to the chambers 19, 20. The valves 4, 5 are connected, as shown in Fig. 1, to a weighted lever 8, which is pivoted to the vessel 1, and carries valves 11, 12 and floats 15, 16, 17, and 18. The filtered sewage or foul water is discharged along pipes 13, 14 having their outer ends curved inwards and formed with perforations 28, 29. By means of this apparatus, one filter bed is being filled while the other bed is being discharged. The apparatus may be used for controlling the flow to or from more than one pair of filter beds. Valves may be fitted to the pipes 2, 3 and 21 and 22, for the purpose of regulating the flow of sewage as the hydrostatic head in the filters or vessel 1 varies ; these valves may be actuated automatically by means of floats. Fig. 3 shows a sectional elevation of an apparatus for delivering foul water to a rectangular filter bed. The water flows from a trough 42 along a siphon 43, and is discharged upon a water-wheel 44, mounted within a hopper 47 forming part of a perforated pipe 48 whence the water is supplied to the bed. The siphon is secured to the pipe 48, which is secured to a travelling carriage driven from the shaft of the water-wheel. Reversal of the carriage is effected at either end of the filter bed by means of a stop which forces the siphon to discharge upon one or other of the sides of the water-wheel. In another form of sewage-distributing apparatus, two or more perforated conduits are connected together and are arranged to travel along double inclined planes, the weight of sewage supplied to the conduits alternately being the propelling force. Reference is made in the Specification to the filter beds described in Specification No. 27,513, A.D. 1896.
Patent GB-189713024-A (GB)
Title: Improvements in the Fire Proofing of Safes.
Inventor: ANTCLIFF HARRY RICHARD
Filed: 1897-05-27
Granted: 1898-05-20
Abstract: 13,024. Antcliff, H. R. May 27. Safes.-The fireproof chambers of safes are filled with a composition of Portland cement, steel or iron filings or scrap, and sal-ammoniac, the chambers being filled up with the composition and then dried in a muffle. The composition described resists drilling as well as heat. An outer fireproof chamber containing the usual alum and sawdust composition may also be employed.
Patent GB-189717679-A (GB)
Title: Improvements in Incandescent Gas Burners.
Inventor: CLAY WILLIAM RICHARD
Filed: 1897-07-28
Granted: 1898-05-28
Abstract: 17,679. Clay, W. R. July 28. Incandescent gas lamps.-Damage to the fragile mantle is prevented by making the gas-supply tube separate from the mixing-tube, and by supporting the latter with its mantle attachments upon spring anti-vibration devices. In the form shown in Fig. 1, the mixing-tube b is supported above the gas-supply pipe a by an external spring f, and the air-supply opening c is protected by a gauze sleeve p. In Fig. 2, the supporting-spring f is shown arranged within the mixing-tube b, and the air-supply opening c may be controlled by an adjustable disc z. Other modifications include the supporting of the part b and its mantle attachments by lateral or overhead springs, as in street lamps ; the supporting of various forms of multiplex burners by a common anti-vibration device ; and the use of a short mixing-tube with an outer collar for protecting the lower edge of the mantle.
Patent GB-189719305-A (GB)
Title: A New or Improved Method or Means of Cleaning the Outside Surfaces of Stone or Brick Buildings.
Inventor: CHILDE HENRY SLADE
Filed: 1897-08-20
Granted: 1898-06-25
Abstract: 19,305. Childe, H. S., and Smith, A. H. Aug. 20. Sand blast.-A sand blast is employed for cleaning the outer surfaces of buildings. It may be connected by flexible tubing with a steam generator, rotary fan, or other air compressing or forcing apparatus, and is carried on a travelling carriage or in any other suitable way.
Patent GB-189724711-A (GB)
Title: Improvements in Machines for Boring Brush-boards and similar Articles.
Inventor: GUSSMANN GUSTAV ADOLF
Filed: 1897-10-25
Granted: 1898-10-08
Abstract: 24,711. Gussmann, G. A. Oct. 25. Machines for making brushes. The stock or blank is fed from the shoot s to the roller t,rotated by bevel gearing, and rests against the roller till pulled beneath it by rotary grippers u on shafts u<6> driven by bevel gearing. The blank stops on reaching the edge of the support p, and is gripped in that position by laterally-moving dogs x worked by a right and left handed screw y rotated by spur gearing, the spur-wheel z of which is rocked by levers z<1>, z<2>. The converging drill spindles a, guided in supports b, are connected by spindles d to driving-spindles e, each end of the spindles d being universally jointed. The spindles e are driven by cords and pulleys g, h, and are mounted on a frame f which is advanced towards the blank, to effect the drilling, by a lever k and a cam on the shaft l. The drilled blank is released by the dogs x, and the support p is pulled from beneath it by levers and links r, r<1>, r<2>.
Patent GB-189726454-A (GB)
Title: Improvements in Apparatus for Regulating the Supply of Combustible Liquid or Vapour to Liquid Fuel Burners.
Inventor: HOUSE HENRY ALONZO
Filed: 1897-11-12
Granted: 1898-10-22
Abstract: 26,454. House, H. A., and Symon, R. R. Nov. 12. Liquid -fuel fittings.-Relates to means for automatically regulating the supply of liquid or vapour to liquid-fuel burners employed for heating steam generators, and more especially to improvements in the apparatus for this purpose described in Specification No. 16,909, A D. 1892. A strainer is preferably combined with the regulating-apparatus. An expansible and collapsable chamber in communication with the steam space of the boiler is connected directly to a valve controlling the supply of liquid or vapour. In the arrangement shown, this chamber A is provided with a flexible diaphragm B; but a sliding piston may replace the diaphragm. The spindle J of the regulating-valve I is pressed against the diaphragm by the spring D, which tends to keep the valve open. When, however, the pressure of steam rises sufficiently to overcome the pressure of the spring, the valve is closed. The regulating-valve I is preferably formed with a small passage which is always open to allow sufficient liquid or vapour to pass to maintain a pilot flame. The diaphragm and valve spindle may, if preferred, be acted on by separate springs. A strainer Q is fitted in the supply pipe, a bye-pass with a valve R being provided to allow the liquid or vapour to pass when the strainer becomes choked with dirt. The Specification mentions the application of the apparatus to stationary, marine, and motor-car boilers.
Patent GB-189730672-A (GB)
Title: Improvements in Hydraulic Motors.
Inventor: TANGRY RAOUL MOREL DE
Filed: 1897-12-28
Granted: 1898-12-28
Abstract: 30,672. Tangry, R. M. de. Dec. 28. Direct explosive-gas pressure apparatus.-A turbine is driven by water flowing from a vessel H to a vessel B. The water is returned and the necessary pressure head obtained by gas explosions in the chamber C. The explosive mixture, supplied from a carburetter, is forced into the chamber C by a pump I driven from a crank on the turbine shaft.
Patent GB-189809680-A (GB)
Title: Improvements in Baking Ovens.
Inventor: GROVE DAVID
Filed: 1898-04-27
Granted: 1898-06-11
Abstract: 9680. Grove, D. April 27. Ovens.-A baking-oven is fitted with two or more hearth-plates, preferably removable, between which are arranged adjustable plates to serve as heatradiating bodies. Fig. 1 shows one arrangement. The oven a, fitted with a fireplace b, has two or more hearths d, e carried on cross-pieces f carrying rollers g running on rails h. The rails are adjustably fixed to the supports c, c<1>. Between d and e is fitted an adjustable plate k to serve as a heating- plate, and a similar plate n may be arranged above e. The hearths may be divided by ribs or partitions. The oven may be fixed or portable.
Patent GB-189811572-A (GB)
Title: Improvements in Brazing Apparatus applicable to Portable Forges.
Inventor: JONES RICHARD
Filed: 1898-05-23
Granted: 1898-12-23
Abstract: 11,572. Jones, R. May 23. Brazing.-A brazing-apparatus, applicable to a portable forge, consists of a gas blowpipe s, adjustably mounted on the blast pipe f between the bellows b and the tuyÞre c. A pipe h, fixed in an elbow or tee-piece g on the blast pipe, has a telescopic pipe i in it, carrying a hemispherical casing e. shown in plan in Fig. 3. The gas pipe r and 'blowpipe s are connected to a second casing d connected to the casing e by a bridle m and pivot screw o, allowing the blowpipe to be swivelled in a vertical plane. The telescopic pipes h, i allow the blowpipe to be adjusted vertically or angularly. The casing d contains a valve a', Fig. 8, operated by a handle k on the screwed end l. The blast passes up through the casing e into the hollow end c<1> of the valve, and out through an aperture d' to the blowpipe as indicated by the large arrow in Fig. 3. Gas passes through the chambers b<1> in the valve by an inlet i<1> and outlet i<2>, as indicated by the small arrows.