Patent SG-11201909429V-A (SG)
Title: 3-(((((2s,5r)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl)oxy)sulfonyl)oxy)-2,2-dimethylprop noate derivatives and related compounds as perorally administered profrugs of beta-lactamase inhibitors for treating bacterial infections
Inventor: GORDON ERIC
IPC: A61K31/439
Filed: 2018-05-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT omit VIII °nolo Holollm H H voila° oimIE (10) International Publication Number WO 2018/208557 Al (51) International Patent Classification: C07D 471/08 (2006.01) A61P 31/04 (2006.01) A61K 31/439 (2006.01) (21) International Application Number: PCT/US2018/030652 (22) International Filing Date: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) W O 20 18/ 208557 Al 02 May 2018 (02.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/504,523 10 May 2017 (10.05.2017) US 62/551,043 28 August 2017 (28.08.2017) US 15/934,497 23 March 2018 (23.03.2018) US (71) Applicant: ARIXA PHARMACEUTICALS, INC. [US/US]; 525 Univercity Ave., Suite 1350, Palo Alto, CA 94301 (US). (72) Inventors: GORDON, Eric, M.; 525 University Ave., Suite 1350, Palo Alto, CA 94301 (US). FREUND, John; 525 University Ave., Suite 1350, Palo Alto, CA 94301 (US). GALLOP, Mark, A.; 525 University Ave., Suite 1350, Pa- lo Alto, CA 94301 (US). DUNCTON, Matthew, Alexan- der, James; 525 University Ave., Suite 1350, Palo Alto, CA 94301 (US). (74) Agent: LAMBERT, William, R.; Sheppard Mullin Richter & Hampton LLP, 379 Lytton Ave., Palo Alto, CA 94301 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: 3 -(((((2 S,5R)-2-CARBAMOYL-7-0X0-1,6-DIAZABICYCLO [3 .2 .1] OCTAN-6-YL)OXY)SULFONYL)OXY)-2,2 - DIMETHYLPROP NOATE DERIVATIVES AND RELATED COMPOUNDS AS PERORALLY ADMINISTERED PROFRUGS OF BETA-LACTAMASE INHIBITORS FOR TREATING BACTERIAL INFECTIONS (57) : 3-(((((25,5R)-2-carbamoy1-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-y1) oxy)sulfonyl)oxy)-2,2-dimethylpropanoate deriv- atives and related compounds as perorally administered prodrugs of beta-lactamase inhibitors for treating bacterial infections, particu- larly in combination with beta-lactam antibiotics.