baber/WOPTO huggingface dataset:
Patent CA-2348156-A1 (CA)
Title: Human proteins involved in endoplasmic reticulum protein degradation
Inventor: CHAU VINCENT
IPC: C12Q1/68
Filed: 1999-10-21
Abstract: The invention relates to degradation of proteins via the ubiquitin-proteasome pathway. More particularly, the invention relates to the degradation of proteins in the ER, including cystic fibrosis transmembrane conductance regulator (CFTR) via the ubiquitin-proteasome pathway. The invention provides methods and compositions for inhibiting such degradation and for promoting the maturation of .DELTA.F508 into a functional CFTR and for understanding the role of loss of CFTR function in CF. The invention resides in the discovery of human proteins responsible for the ubiquitination of .DELTA.F508, CFTR, and .alpha.1-AT.
Patent CA-2348642-A1 (CA)
Inventor: CASDEN MARTIN S
IPC: G06K7/00
Filed: 1999-12-10
Abstract: A hand held passive remote programmer for a microprocessor controlled induction type Radio Frequency Identification (RFID) reader includes a housing containing an antenna (L1, C1), a plurality of dedicated integrated circuit RFID transponder tags (IC1-IC16) each having a unique tag code, and a keypad (22) having a plurality of keys each selectively operable for connecting a corresponding one of the transponder tag Ics to the antenna thereby to power the selected tag IC by induction in the radio frequency sensing field of a RFID reader and thereby enable the unique tag code of the selected tag IC to be read by the RFID reader via conductors (24, 26). Program instructions stored in the RFID reader recognize each unique tag code as representative of actuation of a particular key on the remote programmer keypad and not indicative of the presentation of an access key tag to the reader. Actuation of particular keys or key sequences on the programmer may be recognized by the RFID reader as program instructions for the reader's microprocessor.
Patent CA-2350738-A1 (CA)
Title: Disabled user lift system
Inventor: THOLKES ALAN L
IPC: A63B23/04
Filed: 1999-11-17
Abstract: A user lift system (10) comprises base structure (102) which supports a plurality of surfaces (102) which operate to provide support for a user.
Patent CA-2352936-A1 (CA)
Title: Floral sleeve
Inventor: WEDER DONALD E
IPC: A01G9/02
Filed: 2001-07-12
Abstract: A floral sleeve sized to fit a flower pot, the sleeve generally having a conical shape and having a bonding material disposed thereon for connecting the sleeve to a pot disposed within the sleeve or connected via a banding element to a pot disposed within the sleeve.
Patent CA-2353616-A1 (CA)
Title: Assays for compounds which increase phospholipase a2 activity
Inventor: THOMPSON KEVIN STUART JOHN
IPC: A61P25/28
Filed: 1999-12-07
Abstract: A method of identifying a compound which increases the activity of a phospholipase A2 towards a given phospholipid substrate the method comprising determining whether the activity of phospholipase A2 towards the given substrate is increased in the presence of a compound compared to its activity in the absence of the same compound. A method of identifying a compound which increases the production or expression of phospholipase A2 in a cell the method comprising determining directly or indirectly whether the production or expression of phospholipase A2 in a cell is increased in the presence of a compound compared to its production or expression in the absence of the same compound. A method of treating a psychiatric or neurological disorder such as depression in a patient the method comprising administering an effective dose of a compound which increases the release of docosahexaenoic acid from brain membrane phospholipids. A method of identifying a compound which mimics the effect of docosahexaenoic acid on the glucocorticoid receptor the method comprising contacting the glucocorticoid receptor with a compound and determining whether the compound has substantially the same effect as docosahexaenoic acid on the glucocorticoid receptor.
Patent CA-2358873-A1 (CA)
Title: Polypeptide humain avec multiples domaines du type facteur de croissance epidermique (egf), denomme zntr2
Inventor: HOLLOWAY JAMES L
IPC: A61K48/00
Filed: 2000-01-20
Abstract: Les domaines du type facteur de croissance épidermique sont présents dans de nombreuses protéines remplissant des fonctions biologiques importantes, comme la régulation de la différentiation cellulaire. Zntr2 est un nouveau membre de ce groupe de protéines.
Patent CA-2359065-A1 (CA)
Title: Aqueous peroxide emulsions
Inventor: WESTMIJZE HANS
IPC: C08F14/06
Filed: 2000-01-06
Abstract: The invention relates to aqueous peroxide emulsions, optionally containing anti-freeze and/or further additives, which contain a specific emulsifier system comprising a copolymer of an .alpha.,.beta.-unsaturated dicarboxylic acid and a C8-24 .alpha.-olefin, the acid groups of which are esterified with an ethoxylated alcohol having a degree of ethoxylation of 1-45, as well as an ethoxylated fatty alcohol with an HLB-value greater than 16.
Patent CA-2361605-A1 (CA)
Title: Pyrimidine-2,4,6-triones as inhibitors of matrix metalloproteinases
Inventor: WANG PING
IPC: A61P25/28
Filed: 2000-02-09
Abstract: The novel compounds of formula (I) wherein R1 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substitued alkynyl, alkoxy, substituted alkoxy, aryloxy or alkylalkoxy, and R2 is aryloxy; pharmaceutically acceptable salts of an acidic compound of formula (I), and prodrugs thereof can be used in the treatment or control of cancer associated with overexpression of gelatinase-A and/or gelatinase-B, particularly skin cancer, breast cancer, prostate cancer, colon cancer, lung cancer, and gastric cancer, and are also useful for other diseases associated with unregulated degradation of extracellular matrix, including rheumatoid arthritis, osteoarthritis, multiple sclerosis, corneal ulceration, periodontal disease and the like.
Patent CA-2362918-A1 (CA)
Title: Methods and compositions for treating erectile dysfunction
Inventor: WALDSTREICHER JOANNE
IPC: A61K31/519
Filed: 2000-03-03
Abstract: The present invention provides for a method for the treatment of erectile dysfunction in a male or female human subject in need of such treatment comprising administration of a therapeutically effective amount of an agonis t of the melanocortin receptor in combination with a therapeutically effective  amount of a cyclic-GMP-specific phosphodiesterase inhibitor or an alpha- adrenergic receptor antagonist. Further, the present invention provides for pharmaceutical compositions useful in the methods of the present invention, as well as a method of manufacture of a medicament useful for treating erectile  dysfunction.
Patent CA-2365333-A1 (CA)
Title: Fluid controlled adjustable down-hole tool
Inventor: RUSSELL MARK ALEXANDER
IPC: E21B47/09
Filed: 2000-03-06
Abstract: An adjustable down-hole tool, for example a drill-string stabiliser (10), comprises a body (12) having a through bore (16). A mandrel (18) is rotationally fixed but axially movable in the body, the mandrel being movabl e by fluid pressure in the tool against the action of a first return spring (4 4) between a first, activated position and a second deactivated position. A sleeve (66) is between shoulders (68, 69) on the body and mandrel. Castellations (18a,b, 69a,b) are on the mandrel and facing edge or edges of the sleeve so that, when the castellations are in phase the mandrel is prevented from travelling from said first to second position and when they a re out of phase they interdigitate and the mandrel is not prevented from travelling from said first to second position. A control piston (36) is slidable in the mandrel, being movable by fluid pressure in the tool against  the action of a second return spring (50). The piston is axially slidable wi th respect to said sleeve and rotationally fixed with respect thereto. A circumferential barrel cam (56) is defined on the piston, a cam follower (58 ) being disposed in the mandrel but within the confines of the barrel cam so that axial movement of the piston with respect to the mandrel results in corresponding rotation of the piston with respect to the mandrel.
Patent CA-2367265-A1 (CA)
Title: Powder facility for spray-coating purposes
Inventor: MAUCHLE FELIX
IPC: B05B15/00
Filed: 2002-01-11
Abstract: The invention relates to a power facility used for spray coating and comprising at least one injection unit (6), at least two powder stations (2) and at least one cleaning unit (16) which are mutually displaceable in program-controlled manner in order to alternatively convey powder from one of the powder receptacles of the powder stations or to clean the powder-flow itineraries using compressed cleaning air.
Patent CA-2368114-A1 (CA)
Inventor: THACKSTON JAMES D
IPC: G06F17/50
Filed: 2000-03-10
Abstract: The invention relates generally to a comprehensive, integrated computer-based system and method for undertaking an engineering design and development effort in a virtual collaborative environment (100), composed of prime contractors (220) and suppliers (230) interconnected with a central server (200) via networks (260). The system identifies qualified fabricators for manufacturing a part design based on fabricator capability information stored in a global registry database (210) substantially maintained by the suppliers (230) themselves. The central server (200) conducts a virtual bidding process between the prime contractors (220) and the suppliers (230) using electronic representations of three dimensional model and specification data maintained in the database (210). The central server (200) further supports the bidding process by providing quasi-real time audio, video and graphics, and the contracts negotiation and formalizatin steps.
Patent CA-2369375-A1 (CA)
Inventor: TSUBOUCHI MASANORI
IPC: F02B75/18
Filed: 2002-01-28
Abstract: It is intended to provide a compact and lightweight outboard engine and to prevent its output loss by preventing or minimizing lubricant oil staying in a crank chamber while the engine is driven in a tilt-up condition. For this purpose, the outboard engine (1) mounted to a boat stern by a mounting device having a tilt shaft comprises an engine (2) including a flywheel (56) positioned at a lower end portion of a vertically extending crankshaft, and an oil pan positioned below the flywheel (56). An upper walk of a flywheel chamber (59) accommodating the flywheel 56 is made up of a bottom wall of a crank chamber made of a crankcase (30), etc., and a bottom wall (30a) of the crankcase (30) forming a front portion of the engine body (3) has a return oil path 7l formed forward of an inner circumferential wall surface (60e) of a circumferential wall (60) of the flywheel chamber (59) and having inflow openings (71a, 71b) through which lubricant oil flows from the crank chamber.
Patent CA-2370956-A1 (CA)
Title: Method for causticisation of alkaline solutions
Inventor: ROACH GERALD IAN DUNSTAN
IPC: C01F7/0646
Filed: 2000-04-20
Abstract: A method for the causticisation of an alkaline solution, the method characterised by the step of adding a quantity of lime to the alkaline solution to produce a reaction mixture in such a manner that the reaction temperature of the reaction mixture so produced rapidly exceeds the atmospheric boiling point of the alkaline solution.
Patent CA-2371262-A1 (CA)
Inventor: AHERN BRIAN S
IPC: F23D11/18
Filed: 2000-04-26
Abstract: L'invention concerne un dispositif servant à réduire la pression totale d'un carburant fluide compressible. Le dispositif comprend au moins deux parties d'expansion (10, 20) par enthalpie constante étroitement espacées; chaque partie comporte au moins un orifice (82, 92-96, 112-116), et les orifices de deux parties adjacentes ne sont pas coaxiaux. La réduction de pression réduit la vitesse d'écoulement, lors du mélange avec l'air, à une vitesse inférieure à celle de la flamme afin de faciliter l'allumage et une combustion stable.
Patent CA-2371466-A1 (CA)
Title: Needleless injector
Inventor: MENASSA KARIM
IPC: A61M5/34
Filed: 2002-02-12
Abstract: A needleless injector includes a barrel for receiving an injectable liquid, a nozzle closing one end of the barrel containing an injection orifice; a plunger movable in the barrel for forcing liquid out of the barrel; a piston in the barrel for forcing liquid out of the barrel; a piston in the barrel for movement under gas pressure to move the plunger; a valve for admitting gas under pressure into the barrel behind the piston; a trigger for opening the valve to cause said piston to move against the plunger; and a magnet for retaining the piston in a rest position in said barrel until acted upon by a gas under sufficient pressure to cause the piston and plunger to move to an extended, discharge position. For extra protection, a sterile pad can be disposed between the injection orifice and the skin of a person or animal receiving an injection.
Patent CA-2371565-A1 (CA)
Title: Device for reducing loss of liquid during fraction collection
Inventor: ANDERSSON LARS
IPC: G01N30/82
Filed: 2000-05-12
Abstract: Spillage of liquid during switching of receptacles in a fi-action collector is avoided by introducing a device in the flow path between an inlet tubing (6) and a dispensing means (5), said device comprising an expand-able chamber (34) that accom-modates liquid during the time interval for switching from one receptacle (3) to the next (3').
Patent CA-2372105-A1 (CA)
Title: Gene derive de $i(lawsonia), polypeptides, peptides et proteines d'hemolysine et leurs utilisations
Inventor: PANACCIO MICHAEL
IPC: A61K39/00
Filed: 2000-05-11
Abstract: La présente invention concerne d'une manière générale des compositions thérapeutiques destinées au traitement et/ou à la prophylaxie de maladies intestinales chez des animaux et des oiseaux, provoquées ou exacerbées par Lawsonia intracellularis ou un autre micro-organisme similaire ou associé. L'invention concerne en particulier un nouveau gène dérivé de Lawsonia intracellularis codant pour un peptide, un polypeptide ou une protéine d'hémolysine immunogène, particulièrement utiles en tant qu'antigène dans des préparations vaccinales pour générer chez des animaux hôtes une immunité humorale contre Lawsonia intracellularis et les agents pathogènes associés. L'invention concerne également des méthodes de traitement et/ou de prophylaxie de telles maladies intestinales, ainsi que des agents de diagnostic et des procédés de détection de Lawsonia intracellularis ou de micro-organismes similaires ou associés.
Patent CA-2373080-A1 (CA)
Title: Composition for use as nox trap, combining two compositions based on manganese and another element selected among the alkalines, alkaline-earties and rare earths and use thereof for treating exhaust gases
Inventor: HEDOUIN CATHERINE
IPC: B01J20/06
Filed: 2000-05-05
Abstract: The invention concerns a compound and its use as NO¿x? trap in the treatment of exhaust gases. Said compound is characterised in that it comprises a combination of: a first composition comprising a support and an active phase, the active phase being based on manganese and at least another element A selected among the alkalines and alkaline earths, the manganese and the element A being chemically bound, a second composition comprising a support and an active phase based on manganese and at least another element B selected among the alkalines, the alkaline-earths and rare earths, said second composition having or capable of having a specific surface area of at least 10 m?2¿/g after being calcined for 8 hours at 800 ·C.
Patent CA-2374411-A1 (CA)
Inventor: VLIEGHE PATRICK
IPC: A61P31/18
Filed: 2000-07-11
Abstract: The invention concerns the field of organic chemistry, and more precisely, that of therapeutic chemistry. More particularly, the invention concerns novel esters derived from nucleosides of general formula (I) wherein: A represents a divalent group selected among -(CH¿2?)¿n?-, -(CH¿2?)¿n? -NH-, -(CH¿2?)¿n? -O-; (a); (b); (c); (d); (e); n is an integer ranging between 1 and 12; Z represents an amino, hydroxyl or an alkyl group; and the nucleoside group is the radical of a hydroxylated nucleoside of general formula (1) wherein: R¿1? represents a radical selected among (2) and (3) wherein: R¿4? represents a methyl, trifluoromethyl or halovinyl; R¿2? represents a hydrogen or a hydroxyl; R¿3? represents a hydrogen, a hydroxyl or an azido; and the dotted line represents an optional carbon-carbon double bond. The invention is useful as an antiviral agent.
Patent CA-2376308-A1 (CA)
Inventor: MACAUDIERE PIERRE
IPC: C01F17/00
Filed: 2000-05-31
Abstract: The invention concerns novel rare earth fluorosulphides using four modes of production, novel rare earth oxyfluorosulphides, their preparation methods and their use as dyeing pigment. The fluorosulphide of the first mode corresponds to the formula (LnSF) (Ln represents a rare earth) and has a particle average size of more than 5 µm. That of the second mode is a mixed rare earth fluorosulphide of formula (Ln, Ln')SF and in the form of a solid solution. The fluorosulphide of the third mode, in a first embodiment, comprises at least an alkaline element and has a LnSF-type structure, the rare earth being selected among yttrium and from the group ranging from lanthanum to erbium inclusively. In a second embodiment of said third mode, the fluorosulphide comprises at least an alkaline element, it has a space group hexagonal structure P6¿3?22, the rare earth likewise belonging to the group ranging from holmium to lutetium inclusively, also including yttrium. The fluorosulphide of the fourth mode corresponds to the formula Ln¿2?AF¿4?S¿2? wherein A is an alkaline-earth. The oxyfluorosulphide corresponds to the formula Ln¿3?S¿2?F¿3?O wherein Ln represents at least a trivalent rare earth.
Patent CA-2377160-A1 (CA)
Inventor: SKREPNEK ANDY
IPC: F16B17/00
Filed: 2002-03-18
Abstract: A method and apparatus for interlocking at least one first tube having a first diameter with a second tube having a second diameter which is larger than the first diameter. The first tube is loaded over a mandrel having a punching end, and disposed into a holding block having a holding cavity conforming closely to the outer surface of the first tube. The second tube is disposed over a receiving block, which has a receiving cavity conforming closely to the outer surface of the first tube.  The punching end of the mandrel is driven through the second tube and into the cavity in the receiving block, followed by the first tube. When the first tube reaches a lower limit of the receiving cavity, the first tube is compressed axially. The mandrel supports the interior of the first tube, the holding cavity prevents the trailing portion of the first tube from swelling outwardly, and the receiving cavity prevents the leading portion of the first tube from swelling outwardly. Thus, the portion of the first tube disposed inside the second tubular member swells under the axial compressive force, permanently interlocking the first tube with the second tube. The punching steps can be separated from the remaining steps of the method of the invention, or the second tube can be pre-punched.
Patent CA-2377891-A1 (CA)
Title: A method and system for detecting arcing faults and testing such system
Inventor: BROOKS STANLEY J
IPC: H01R4/36
Filed: 2000-06-19
Abstract: A system for detecting arcing faults in an electrical distribution network having a line conductor (16) carrying an electrical signal between a power source (14) and a load, is capable of detecting series arcs, line-to-neutral  arcs and line-to-ground arcs. The system includes a sensor (21) coupled to t he line conductor (16) for monitoring the electrical signal and generating a representative sensor signal. The system generates an arc-indicative signal (10) in response to the sensor signal having characteristics indicative of a n arcing fault. A test wire is coupled to the sensor simultaneously with the line conductor and a test signal is periodically produced on the test line. The sensor (21) also monitors the test and produces a sensor signal representing both the test signal and the electrical signal when the test signal is present on the test line. The arcing fault detection system (10) generates an arc-indicative signal in response to the sensor (21), signal associated with either the test line or line conductor (16) having characteristics indicative of an arcing fault. A diagnostic test integrator (72) generates a trip signal to trigger the interruption (22) of the electrical signal in response to certain status conditions of the test signa l and the arc-indicative signal.
Patent CA-2381858-A1 (CA)
Inventor: BUES MICHEL
IPC: H02B13/035
Filed: 2000-10-12
Abstract: The invention relates to a metal-clad electrical switch with a metallic jacket (1) and with gas insulation. The inside volume of said jacket is divided into at least two adjacent compartments (1B, 1C) that are separated by an impervious wall (3). A first disconnector (4) is arranged in one of said compartments and comprises a first cutter (4A) which interacts with a first binding post (4B). A second disconnector is arranged in the other compartment and comprises a second cutter (5A) which interacts with a second binding post (5B). The cutters are linked to a common rotary shaft (7) which crosses said wall in an impervious manner and ensures the conduction of electricity between the cutters.
Patent CA-2389764-A1 (CA)
Title: Naphthopyrans with a heterocycle in the 5,6-position, preparation, and compositions and matrices containing them
Inventor: CHAN YOU-PING
IPC: G02C7/02
Filed: 2000-11-01
Abstract: The invention relates to novel compounds of the naphthopyran type with a fus ed heterocycle in the 5,6-position. These compounds have formula (I) or (II). These compounds (I) or (II) have valuable photochromic properties. The invention further relates to their preparation, to their applications as photochromic substances and to the compositions and matrices comprising them .
Patent CA-2392328-A1 (CA)
Title: Dispersion shifted large effective area waveguide fiber
Inventor: LIU YANMING
IPC: G02B6/036
Filed: 2000-10-23
Abstract: Disclosed is a dispersion shifted optical waveguide fiber having low but non-zero dispersion over an extended wavelength window that includes wavelengths, from 1470 nm to 1625 nm. Waveguide fiber core refractive index profiles exhibit the desired dispersion performance while maintaining resistance to pin array and lateral load bending at least equivalent to standard waveguide fiber. Attenuation over the operating wavelength range is low and zero dispersion wavelength is typically less than 1450 nm.
Patent CA-2393253-A1 (CA)
Title: Pulsed excited proximity sensor
Inventor: CHRISTENSEN TIMOTHY ALAN
IPC: G01V3/10
Filed: 2002-07-12
Abstract: A proximity sensor (10) has a transducer coil (18) that is part of an oscillator circuit. The oscillating signal varies as a function of the presence or absence of a metallic object adjacent the transducer coil (18). By analyzing selected characteristics of that oscillating signal, the presence of and object and the distance to the object can be determined. Other analysis techniques enable the sensor to distinguish between ferrous and non-ferrous materials. A mechanism (130-140) also is provided to automatically configure operation of the proximity to avoid interference from another adjacent proximity sensor (10).