Patent SG-11201901634U-A (SG)
Title: An hbv antigen specific binding molecules and fragments thereof
Inventor: BERTOLETTI ANTONIO
IPC: C12N15/63
Filed: 2016-09-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 March 2018 (29.03.2018) WIPO I PCT olimion °nolo omm Imo Imo oimIE (10) International Publication Number WO 2018/056897 Al (51) International Patent Classification: C07K 14/725 (2006.01) A61P 31/00 (2006.01) C12N 15/12 (2006.01) A61P 31/20 (2006.01) C12N 15/63 (2006.01) A61P 35/00 (2006.01) A61K 38/17 (2006.01) (21) International Application Number: PCT/SG2016/050469 (22) International Filing Date: 23 September 2016 (23.09.2016) (25) Filing Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(10) of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) W O 20 18/05 6897 Al (26) Publication Language: English (71) Applicant: LION TCR PTE. LTD. [SG/SG]; 20 Maxwell Road, #07-08/09/10 Maxwell House, Singapore 069113 (SG). (72) Inventors: BERTOLETTI, Antonio; c/o Duke-nus Grad- uate Medical School, 8 College Road, Singapore 169857 (SG). TANOTO, Tan Anthony; c/o Lion TCR PTE LTD 20 Maxwell Road, #07-08/09/10 Maxwell House, Singa- pore 069113 (SG). KOH, Sheau Fung, Sarene; c/o Lion TCR PTE LTD 20 Maxwell Road, #07-08/09/10 Maxwell House, Singapore 069113 (SG). HO, Zack; c/o Lion TCR PTE LTD 20 Maxwell Road, #07-08/09/10 Maxwell House, Singapore 069113 (SG). (74) Agent: YUSARN AUDREY; 24 Raffles Place, #27-01 Clifford Centre, Singapore 048621 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: AN HBV ANTIGEN SPECIFIC BINDING MOLECULES AND FRAGMENTS THEREOF (57) : Hepatitis B Virus (HBV) antigen specific binding molecules, in particular T Cell Receptors (TCRs), TCR polypeptides and fragments thereof. The invention is also related to modified cells containing the TCRs, TCR polypeptides or fragments, pharma- ceutical composition or kits including the same or methods of making or using the same as is described. In particular, the invention discloses TCRs or a fragments thereof, capable of binding to a peptide of a Hepatitis B Virus (HBV) Env polypeptide presented by an MHC class I molecule comprising an MHC class I 6-chain encoded by an HLA-Cw*08 allele.