Patent SG-11201908542Q-A (SG)
Title: Gip receptor activating peptide
Inventor: ASAMI TAIJI
IPC: C07K14/605
Filed: 2018-03-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT °Ens °nolo HE onoilooimmo oimIE (10) International Publication Number WO 2018/181864 Al (51) International Patent Classification: C07K 14/605 (2006.01) A61K 38/00 (2006.01) (21) International Application Number: PCT/JP2018/013540 (22) International Filing Date: 30 March 2018 (30.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2017-072556 31 March 2017 (31.03.2017) JP (71) Applicant: TAKEDA PHARMACEUTICAL COMPA- NY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, Chuo- ku, Osaka-shi, Osaka, 5410045 (JP). (72) Inventors: ASAMI Taiji; c/o TAKEDA PHARMA- CEUTICAL COMPANY LIMITED, 26-1,Muraoka-Hi- gashi 2-chome, Fujisawa-shi, Kanagawa, 2510012 (JP). NISHIZAWA Naoki; c/o TAKEDA PHARMACEUTI- CAL COMPANY LIMITED, 26-1,Muraoka-Higashi 2- chome, Fujisawa-shi, Kanagawa, 2510012 (JP). NII- DA Ayumu; c/o TAKEDA PHARMACEUTICAL COM- PANY LIMITED, 26-1,Muraoka-Higashi 2-chome, Fuji- sawa-shi, Kanagawa, 2510012 (JP). KANEMATSU Yoko; c/o TAKEDA PHARMACEUTICAL COMPANY LIMIT- ED, 26-1,Muraoka-Higashi 2-chome, Fujisawa-shi, Kana- gawa, 2510012 (JP). ADACHI Mari; c/o TAKEDA PHARMACEUTICAL COMPANY LIMITED, 26-1,Mu- raoka-Higashi 2-chome, Fujisawa-shi, Kanagawa, 2510012 (JP). TAKEKAWA Shiro; c/o TAKEDA PHARMA- CEUTICAL COMPANY LIMITED, 26-1,Muraoka-Hi- gashi 2-chome, Fujisawa-shi, Kanagawa, 2510012 (JP). MORIMOTO Tomoko; c/o TAKEDA PHARMACEUTI- CAL COMPANY LIMITED, 26-1,Muraoka-Higashi 2- chome, Fujisawa-shi, Kanagawa, 2510012 (JP). (74) Agent: OHNO Seiji et al.; OHNO & PARTNERS, Marunouchi Kitaguchi Building 21F, 6-5, Martmouchi 1- chome, Chiyoda-ku, Tokyo, 1000005 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 1-1 00 pc (54) Title: GIP RECEPTOR ACTIVATING PEPTIDE 1-1 0, - -- 13 (57) : The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament. Specifically, a peptide containing a sequence represented by the formula (I) or a salt © thereof and a medicament comprising the same are provided. P l -Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A 1 1-Al2-A13-A14-A15- A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-P (I) 2 C wherein each symbol is as defined herein.