baber/WOPTO huggingface dataset:
Patent EP-0161852-B1 (EP)
IPC: G01N33/68
Filed: 1985-04-26
Granted: 1992-03-18
Abstract: Human GRF(hGRF), rat GRF(rGRF), porcine GRF(pGRF) and bovine GRF(bGRF) have been earlier characterized and synthetized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in animals, including humans, which have resistance to enzymatic degradation in the body, and which have the sequence: R1-R2-R3-Ala-Ile-Phe-Thr-R8-Ser-R10-Arg-R12-R13-R14-R15-Gln-R17-R18-Al a-Arg-Lys-Le u-R23-R24-R25-Ile-R27-R28-R29-Gln-Gln-Gly-Glu-R34-Asn-Gln-Glu-R38-R39- R40-Arg-R42- R43-R44 wherein R1 is Tyr, D-Tyr, Met, Phe, D-Phe, pCl-Phe, Lou, His or D-His having either a C< alpha >Me or N< alpha >Me substitution or being unsubstituted; R2 is Ala, D-Ala or D-NMA; R3 is Asp or D-Asp; R8 is Ser, Asn, D-Ser or D-Asn; R10 is Tyr or D-Tyr; R12 is Arg or Lys; R13 is Ile or Val; R14 is Leu or D-Leu; R15 is Gly or D-Ala; R17 is Leu or D-Leu; R18 is Tyr or Ser; R23 is Leu or D-Leu; R24 is His or Gln; R25 is Glu, Asp, D-Glu or D-Asp; R27 is Met, D-Met, Ala, Nle, Ile, Leu, Nva or Val; R28 is Asn or Ser; R29 is Arg or D-Arg; R34 is Arg or Ser; R34 is Gln or Arg; R39 is Arg or Gly; R40 is Ser or Ala; R42 is Phe, Ala or Val; R43 is Asn or Arg; R44 is a natural amino acid; provided however that any or all of the residues between R28 and R44, inclusive, may be deleted and provided also that R2 is D-NMA and/or R14 is D-Leu and/or R29 in is D-Arg. Those peptides as well as their nontoxic salts may also be used diagnostically.
Patent EP-0174760-B1 (EP)
IPC: B28B11/08
Filed: 1985-08-22
Granted: 1989-11-23
Abstract: In the manufacture of roof tiles comprising extruding a continuous shaped ribbon of tile forming material onto a succession of pallets, and cutting the ribbon where pallets adjoin to form individual green state tiles on pallets, there is performed the step of causing a cutting tool to engage with the upper surface of the ribbon only for part of the length of each pallet whereby a recess is formed in the upper surface of each tile. In a particular embodiment the recess is a channel cut in the tile at a location immediately downstream of the extruding step. The recess is also subsequently smoothed by applying a smoothing roll thereto.
Patent EP-0168309-B1 (EP)
IPC: C07D215/56
Filed: 1985-06-20
Granted: 1988-03-09
Abstract: 1. Derivatives of isoxazoloquinolinone characterized in that they answer to the general formula l  see diagramm : EP0168309,P8,F1  in which R represents a hydrogen, fluorine, chlorine or bromine atom, a linear alkyl radical containing from 1 to 5 carbon atoms, or branched alkyl radical containing from 3 to 5 carbon atoms, an alkoxy radical containing from 1 to 5 carbon atoms, a nitro or trifluoromethyl radical and R1  represents a phenyl radical possibly substituted by a linear alkyl radical containing from 1 to 5 carbon atoms, or a branched alkyl radical containing from 3 to 5 carbon atoms, by an alkoxy radical containing from 1 to 5 carbon atoms, or by a halogen atom.
Patent EP-0162812-B1 (EP)
IPC: C07K16/24
Filed: 1985-05-15
Granted: 1993-09-01
Abstract: The invention relates to purified human macrophage migration inhibitory factor (human MIF) and its individual proteins, to a process for the purification of human MIF and for the isolation of its individual proteins, to monoclonal antibodies against human MIF, derivatives thereof, processes for the preparation of these antibodies and derivatives thereof, hybridoma cell lines which produce these antibodies, processes for the preparation of said hybridoma cell lines, and to the use of the monoclonal antibodies and derivatives thereof for the qualitative and quantitative determination of human MIF in biological fluids and on cell surfaces, and to the use of the monoclonal antibodies for the purification of human MIF. Human MIF and monoclonal antibodies against human MIF are important for the diagnosis and therapy of immunoregulatory disorders and chronic inflammatory disorders.
Patent EP-0183752-B1 (EP)
Title: Culotte a ceinture elastique, et son procede de fabrication
IPC: A61F13/494
Filed: 1985-05-13
Granted: 1989-11-15
Abstract: Culotte, notamment couche-culotte, formée d'une pièce rectangulaire (40) de matériau souple et comprenant deux éléments allongés s'étendant le long des bords longitudinaux de la pièce, munis d'élastiques (45) à l'état tendu et solidaires, par leurs extrémités, des extrémités longitudinales de la pièce (40), pour former deux éléments élastiques de ceinture pour la culotte en forme de slip.
Patent EP-0187855-B1 (EP)
IPC: C08G59/40
Filed: 1985-07-16
Granted: 1993-02-10
Abstract: Partially advanced epoxy resin compsn. in the reaction prod. of (A) relatively low equiv. wt. epoxy resin(s) having an ave. of more than 1 vicinal epoxy gp. per molecule; (B) extender material(s) having an ave. of 2 active H per molecule reactive with vicinal epoxy gps.; and (c) at least one of: (C1) catalyst(s) for promoting the reaction between (A) and (B); (c2) epoxy resin curing agent(s); or (c3) combination of (c1) and (c2). (A), (B) and (C) are present in quantities which provide: 0.1-0.9 active H equivs. in (B) per epoxide equiv. in (A); 0.05-0.9 equiv. of (c2) per epoxide equiv. in (A) and the combined equivs. of (B) and (c2) per epoxide equiv. of (A) is 0.15:1-1.1:1; and on 0-0.1 mol. of (c1) per equiv. of epoxide in (A). The novelty isthat the compsn. is partially advanced in the absence of a solvent to the extent that the melt viscosity (MV) is at least 20% higher than that of the initial mixt. of (A), (B) and (C) and that the compsn. is melt flowable at or below 25 deg.C. Cured prod. contg. the compsn. is also claimed.
Patent EP-0212604-B1 (EP)
Inventor: MAYS ALFRED THOMAS
IPC: D04H1/56
Filed: 1986-08-13
Granted: 1994-02-16
Abstract: L A water-impervious, smooth-surfaced, gas-permeable, bacterial barrier, repellent treated, laminated material is described. A preferred embodiment compirses a ply of hydrophobic microfine fibers fuse bonded to a layer of conjugate fibers having a low melting sheath and a high melting core. The ply of hydrophobic microfine fibers is low melting. The sheaths of the conjugate fibers have been fuse bonded to the hydrophobic microfine fibers at a temperature below the melt temperature of the cores of the conjugate fibers so that the cores retain their initial fiber-like integrity. The laminated material is preferably impregnated with both a repellent binder and a repellent finish to secure good repellency, lamination and peelability.
Patent EP-0216151-B1 (EP)
IPC: C07C45/82
Filed: 1986-08-20
Granted: 1991-03-06
Abstract: A process for the production of 2-ethyl-hexanol comprising reacting propene with carbon monoxide and hydrogen, in the presence of an aqueous catalyst containing rhodium and at least one sulfonated triarylphosphine, to form an aqueous phase and an organic phase, said organic phase comprising a mixture of materials having boiling points lower than that of n-butanal and substances having boiling points equal to or higher than that of n-butanal, said materials including i-butanal, separating said material from said substances, subjecting said substances to aldol condensation, in the presence of aqueous alkali, to form 2-ethyl hexenal, first hydrogenating said 2-ethyl-hexenal in a gas phase in the presence of a first hydrogenation catalyst and thereafter hydrogenating said 2-ethyl-hexenal in a liquid phase to form 2-ethyl-hexanol in the presence of a second hydrogenation catalyst.
Patent EP-0223954-B1 (EP)
IPC: H01F27/10
Filed: 1986-09-19
Granted: 1989-08-09
Abstract: A compact valve choke that is simple to manufacture, which can, however, ensure the qualities required for all operating modes, namely the needed dielectric strength and freedom from partial discharges between components that are at different voltages. This valve-choke is achieved by having: the choke windings arranged in a supporting frame in a self-supporting manner, in relation to one leg of the choke core; the choke windings potted on all sides, and the potted block supported in the supporting frame by means of fittings; the choke core consists of two generally circular-shaped cores and is secured in the supporting frame; and the choke coil includes two primary windings wound in two layers, with an outer first winding portion and a concentric inner second winding portion as well as, a core-potential center tap roughly in the center of the windings between the first winding portion and the second winding portion.
Patent EP-0219026-B1 (EP)
IPC: H04R25/00
Filed: 1986-10-06
Granted: 1990-06-13
Abstract: A hearing aid which can be built into a frame, such as eyeglasses, to be worn by a hearing-impaired person has a first microphone arrangement having a directional reception pattern, and a second microphone arrangement for sound locating. The second microphone arrangement includes a first locating microphone disposed in the region of one ear of the hearing-impaired person, and a second locating microphone disposed in the region of the other ear. The signal from both locating microphones are mixed by a low-pass filter with the signal from the microphone arrangement having a directional reception pattern, and the output of the mixing operation is supplied in common to both ears of the hearing-impaired person.
Patent EP-0218252-B1 (EP)
IPC: B29C48/49
Filed: 1986-10-09
Granted: 1991-12-27
Abstract: Multilayer coextruded polymer slabs and structural shapes are obtained by simultaneous extrusion of different polymers in a single extrusion head wherein at least one of the diffe­rent layers consists of a vinyl-aromatic polymer containing up to 20% by weight of an ethylenically unsaturated nitrile.
Patent EP-0202080-B1 (EP)
IPC: B60R22/06
Filed: 1986-05-09
Granted: 1991-02-27
Abstract: A passive vehicle seat belt system includes measures to prevent overheating of the drive motor and obstruction of system operation. Drive motor excess current demand is sensed to effect motor de-energization and/or disabling of latching means of a retractor included in the system and/or operation of an indicator light. The indicator light can prompt manual motor de-energization. Disabling of retractor latching means can be effected by a belt movement command signal. Retractors with means for signalling operation of latching means, with solenoid means for disabling latching means, and with means for indicating when a predetermined belt length has been received therein, are described.
Patent EP-0207119-B1 (EP)
Title: Plaques ceramiques luminescentes
IPC: H01J29/86
Filed: 1985-12-12
Granted: 1990-06-06
Abstract: Une plaque céramique susceptible de luminescence lorsqu'elle est exposée à des rayons X ou autre rayonnement ionisant comprend une fine poudre liée dans du verre liquide, tel que des silicates d'hydroxyle de potassium ou sodium, ou des borates de potassium ou sodium. La poudre présente généralement une taille particulaire moyenne inférieure à 50 mum, par exemple 10 mum. La poudre se compose de borate de calcium, aluminate d'yttrium, silicate de zinc yttrium, silicate de calcium, germanate de calcium, borate de magnésium, borate de baryum, borate de strontium. Les substances dopantes peuvent être Tb, Tm, Ce, Eu, Pr, Yb, Mn, Cu, Ag, Pb en quantités égales ou supérieures à 15% en poids. La plaque est formée en mélangeant la poudre et le verre liquide de manière à former une pâte. La pâte est pressée dans un moule pour éliminer le verre liquide excédentaire et elle est cuite à environ 950oC pendant environ 8 heures. Alternativement, il est possible d'utiliser de l'eau excédentaire en mélangeant la poudre et le verre liquide. On laisse cette eau excédentaire s'évaporer pendant que la plaque est dans un moule avant le pressage et la cuisson. Cette plaque peut être utilisée comme plaque frontale d'un tube cathodique, comme détecteur dans un système thermoluminescent à rayons X ou dans un scintillateur à rayons X.
Patent EP-0257026-B1 (EP)
IPC: B25B27/06
Filed: 1986-02-18
Granted: 1991-04-10
Abstract: Tools for the disassembly of a universal joint comprise two embodiments, a push-type tool and a pull-type tool. With respect to the push-type tool (Fig. 6), a cylinder/piston combination (18, 20) is mounted on a pushing or support assembly (80), and the cylinder/piston combination (18, 20) is operated to force the piston (20) against the support assembly (80), which in turn exerts a pushing force on the cross (intersection point of the yoke members) of the universal joint. At the same time, the cylinder (18), which is connected to the near end of a yoke member of the universal joint, exerts a pulling force on the universal joint, thereby forcing a journal bearing out of the yoke member. In the pull-type tool (Fig. 3), a cylinder/piston combination (18, 20) interposed between a pulling assembly (12, 14, 16) and a pushing assembly (28, 30) operates to cause the exertion of pulling and pushing forces on the universal joint, so that a journal bearing is forced out of the universal joint.
Patent EP-0294511-B1 (EP)
IPC: H03J1/00
Filed: 1986-02-20
Granted: 1990-05-02
Abstract: As a tuning aid in mobile radio reception, the use of a digital information item within the broadcast signal is proposed which contains a sequence of individual lists, optimised to the respective transmitters of a transmitter chain, of alternative frequencies on which the same program signal can be received. In this arrangement, the operating frequencies of the individual transmitters of the transmitter chain are in each case provided at the beginning of the individual lists. <IMAGE>
Patent EP-0235006-B1 (EP)
IPC: H02B13/02
Filed: 1987-02-02
Granted: 1990-10-31
Abstract: A metalclad substation having a busbar isolating switch including an operating mechanism housed in the busbar compartment. The movable contacts of the isolating switch are housed in a compartment separated by a tight insulating partition from the busbar compartment. Tight partitioning of the compartments enables operations to be carried out in the different compartments while maintaining at least one of the busbars switched on to supply the unaffected part of the installation.
Patent EP-0290453-B1 (EP)
IPC: A01G13/02
Filed: 1987-01-26
Granted: 1991-05-15
Abstract: The shelter comprises at least one stake (1), having at least one longitudinally extending slot (2), and an enclosure which comprises at least one section (3) of material, the arrangement being such that said section or sections is or are attached to and removed from the stake or stakes by sliding an edge (4) or fold (5) of the or each section into a said slot. The or each section preferably comprise a flat sheet of relatively flexible material which, in use, is bent at least partially around the plant. Thus, one stake, and one section which encircles the plant, may be provided, or a number of stakes and sections may be provided which are arranged around the plant. Alternatively, the enclosure may be of tubular form and attached via a longitudinal fold in the material. As a further alternative, the section may be of rigid sheet, e.g. of faced corrugated plastics, which is sharply bent along appropriate corrugations to surround the plant.
Patent EP-0265467-B1 (EP)
Title: Procede pour faciliter la formation de spherules lipidiques en dispersion dans une phase aqueuse et pour ameliorer leur stabilite et leur taux d'encapsulation, et dispersions correspondantes
IPC: A61Q5/00
Filed: 1987-04-17
Granted: 1990-07-04
Abstract: La formation de sphérules lipidiques en dispersion dans un milieu aqueux, la stabilité et le taux d'encapsulation desdites sphérules lipidiques sont améliorés par le fait qu'avant la formation desdites sphérules on ajoute au(x) lipide(s) destiné(s) à constituer les feuillets des sphérules, au moins un cholestérol-sulfate de cation ammonium, alcalin ou alcalino-terreux.
Patent EP-0265481-B1 (EP)
Title: Contre-reflecteur et methode de sechage d'une bande a l'aide de celui-ci
IPC: F26B3/28
Filed: 1987-04-27
Granted: 1991-04-03
Abstract: Un contre-réflecteur destiné à être utilisé pour le séchage de bandes, par exemple dans une machine à fabriquer du papier, reçoit un rayonnement thermique qui a traversé le papier, et renvoie l'énergie à la bande par réflexion. Le contre-réflecteur comporte un bâti, des écrans (5) en vitraux céramiques faisant face à la bande de papier et possédant une chambre (14) pressurisée avec un gaz de séchage, lequel sort par des ouvertures (10; 11, 12, 13) dans et entre les écrans (5) en vitraux céramiques, et ainsi, le côté de la bande de papier faisant face au contre-réflecteur est séché de manière continue et régulière par le rayonnement thermique réfléchi ainsi que par le flux de gaz chaud. Les conditions de séchage/traitement de la bande de papier sont ainsi aisément maîtrisées. Le flux de gaz dégagé sert également à pressuriser et ainsi à stabiliser l'espace entre le contre-réflecteur et la bande adjacente, et à maintenir espacée cette dernière du premier en cas de saturation par la chaleur. Le contre-réflecteur est conçu pour emmagasiner toute la chaleur supplémentaire produite dans la zone de séchage/traitement.
Patent EP-0294680-B1 (EP)
Title: Case with connecting terminals
Inventor: KAADEN PETER
IPC: H01R4/36
Filed: 1988-05-30
Granted: 1994-05-11
Abstract: 2.1 In housings having connecting terminals (4) arranged offset in a stepped manner in rows, it is intended that the associated contact connecting screws (5) should be freely accessible, with any desired wiring sequence. 2.2 The insertion openings (13) of the connecting terminals (4) are located on one side of the housing having connecting terminals (4), and their contact connecting screws (5) are accessible on a housing side located at right angles thereto. The connecting terminals (4) of the step which is located closer to the housing side having access to the insertion openings (13) of the connecting terminals (4), also has the shortest distance to the housing side on which the contact connecting screws (5) are accessible. In addition, at least a proportion of the connecting terminals (4) are provided on the side facing away from the contact connecting screws (5) with an electrical terminal lead (9) which is led past the insertion openings (13) of another row of connecting terminals in an insulated manner. 2.3 The essential use is, for example, in 22.5 mm wide housings which are used for the installation of electromechanical and electronic units. <IMAGE>
Patent EP-0302443-B1 (EP)
Title: Method and device for applying a packaging envelope
IPC: B65B59/00
Filed: 1988-08-02
Granted: 1993-05-12
Abstract: Method and device for applying a sleeve-shaped packaging envelope to objects which are provided alternatively in one or two planes lying one above the other. A displacement means is provided which moves the two separate feeding and conveying devices for the packaging envelope and the objects to the respectively necessary distance from one another. <IMAGE>
Patent EP-0308720-B1 (EP)
Title: Powered undercarriage wheel set with an adjustable wheel base for low-floor urban trams
IPC: B61F3/16
Filed: 1988-09-07
Granted: 1992-07-15
Abstract: A driven running gear is provided for urban tram carriages having an extremely low floor which is preferably accessible with one step, it being possible to use said running gear without substantial changes for different track gauges. For this purpose, a swivellable wheel unit (1) and a driving motor (3) and a gearing (2) which connects the wheel unit (1) to the driving motor (3) are arranged on longitudinal carriers (10) of the undercarriage frame, the cross carrier (4) having a length which gives rise to the track gauge of the running gear. <IMAGE>
Patent EP-0330760-B1 (EP)
Inventor: ANDRES ERNST DR
IPC: G01N33/24
Filed: 1988-12-24
Granted: 1994-05-04
Abstract: There is described a process for determining the optimum amount of fertiliser, where the environmental factors which are decisive for plant growth and the yields obtained after the fertilisation has been carried out are measured and areas of the same environmental combination are determined, while taking into account the nutrient supply in the soil.
Patent EP-0277791-B1 (EP)
IPC: C07D401/12
Filed: 1988-02-01
Granted: 1993-06-02
Abstract: The invention relates to compounds having the general formula (I)   <CHEM>  wherein  n is zero, 1 or 2;  each of R1 and R2 is independently:     a) hydrogen, halogen, trifluoromethyl or C1-C6 alkyl;   b) hydroxy, C1-C6 alkoxy or C3-C4 alkenyloxy;   c) nitro, amino, formylamino or C2-C8 alkanoylamino;  R3 represents hydrogen or C1-C8 alkyl;  R4 is:       a') C1-C20 alkyl, unsubstituted or substituted by <CHEM> wherein each of Ra and Rb is independently phenyl or C1-C6 alkyl, or Ra and Rb, taken together with the nitrogen atom to which they are linked, form a N-pyrrolidinyl, N-piperazinyl, hexahydroazepin-1-yl, thiomorpholino, morpholino or piperidino ring, wherein said heterocyclic rings may be unsubstituted or substituted by C1-C6 alkyl or phenyl;   b') C5-C10 cycloalkyl, unsubstituted or substituted by methyl; c') 2- or 3-pyrrolidinyl, piperidyl of 2-piperazinyl, wherein said heterocyclic rings may be unsubstituted or substituted by C1-C6 alkyl; d') isoxazolyl or thiazolyl, wherein said heterocyclic rings may be unsubstituted or substituted by C1-C6 alkyl; e') pyridyl, unsubstituted or substituted by one or two substituents chosen independently from halogen, C1-C6 alkyl and C1-C6 alkoxy; or f') phenyl, unsubstituted or substituted by one or two substituents chosen independently from halogen, CF3,C1-C6 alkyl, C1-C6 alkoxy, amino, nitro, formylamino and C2-C8 alkanoylamino, and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the treatment of neoplastic diseases and acute and chronic infections of both bacterial and viral origin in mammals.
Patent EP-0284407-B1 (EP)
Title: 3'-azido-3'-deoxythymidine controlled-release formulations
IPC: A61K9/54
Filed: 1988-03-25
Granted: 1991-05-29
Abstract: The invention relates to pharmaceutical formulations comprising discrete units of zidovudine provided with a controlled release coating in which the said units are preferably in the form of spheroids.
Patent EP-0292161-B1 (EP)
Inventor: TSIEN ROGER YONCHIEN
IPC: C07D317/58
Filed: 1988-05-06
Granted: 1995-04-12
Abstract: The present invention discloses a new class of calcium chelating compounds which have a decreased affinity for calcium following illumination. These new compounds contain a photolabile nitrobenzyl derivative coupled to a tetracarboxylate Ca<2><+> chelating parent compound having the octacoordinate chelating groups characteristic of EGTA or BAPTA. However unlike EGTA or BAPTA-like compounds, in which the two halves of the chelator are linked by a simple 1,2-ethanediyl moiety, the compounds of the present invention modify the stereochemical conformation of this linkage by adding bulky substituents or incorporating the linkage into a carbocyclic or heterocyclic ring. In a first form, the new compounds are comprised of a BAPTA-like chelator coupled to a single 2-nitrobenzyl derivative, which in turn is a photochemical precursor of a 2-nitrosobenzophenone. In a second form, the new compounds are comprised of a BAPTA-like chelator coupled to two 2-nitrobenzyl derivatives, themselves photochemical precursors of the related 2-nitrosobenzophenones.
Patent EP-0291304-B1 (EP)
IPC: C07D499/00
Filed: 1988-05-12
Granted: 1992-02-26
Abstract: During the preparation of 6-(substituted methylene)-2-penem compounds (which are known for their antibacterial and  beta -lactamase inhibitory properties) mixtures of the E-isomer and the Z-isomer may be formed. The Z-isomer is, however generally preferred, and the present invention provides a process whereby the E-isomer may be converted into the Z-isomer by reaction with an aromatic heterocyclic thiol in the presence of a base.