baber/WOPTO huggingface dataset:
Patent ES-544202-A0 (ES)
IPC: C07D295/185
Filed: 1985-06-14
Abstract: Compounds according to the formulaand the pharmaceutically acceptable acid addition salts thereof wherein:n is an integer of 1 to 6;R, is hydrogen or alkyl of 1 to 4 carbon;R<sub>2</sub> is hydrogen or R, and R<sub>2</sub> are combined to form a carbonyl group;R<sub>3</sub> is hydrogen, alkyl of 1 to 6 carbons, phenyl, benzyl, hydroxy lower alkyl and its acylates, carbamoyl alkyl, carboxyalkyl, alkoxycarbonylalkyl or amino acid side chains;R<sub>4</sub> is hydrogen, alkyl of 1 to 6 carbons, benzyl, or hydroxy lower alkyl;Y is hydrogen, alkyl of 1 to 4 carbon atoms, halo or lower alkoxy;is an amide forming group wherein the nitrogen substituents are: hydrogen; alkyl of 1 to 6 carbon atoms; hydroxyalkyl of 1 to 6 carbon atoms and its aliphatic acylates of 1 to 6 carbon atoms or aryl acylates of 7 to 12 carbon atoms; cycloalkyl of 3 to 8 carbon atoms or cycloalkyl lower alkyl of 4 to 12 carbon atoms wherein the cycloalkyl ring is unsubstituted or substituted with a lower alkyl, lower alkoxy, -OH, -OCOR<sub>5</sub>, halo, -NH<sub>2</sub>, -N(R<sub>5</sub>)<sub>2</sub>, -NHCOR<sub>s</sub>, -COOH, or -COO(R<sub>5</sub>) group wherein R<sub>s</sub> is lower alkyl; phenyl or phenyl lower alkyl wherein phenyl is unsubstituted or substituted with 1 or more lower alkyl, halo or lower alkoxy groups or an -NH<sub>2</sub>, -N(R<sub>5</sub>)<sub>2</sub>, -NHCOR<sub>5</sub>, -COOH, or -COOR<sub>5</sub> group wherein R<sub>5</sub> is lower alkyl; morpholinyl; piperidinyl; perhexylenyl; N-loweralkylpiperazinyl; pyrrolidinyl; tetrahydroquinolinyl; tetrahydroisoquinolinyl; (±)-decahydroquinolinyl or indolinyl. These compounds are cyclic AMP phosphodiesterase inhibitors useful as antithrombotic agents and the like in mammals. The compounds also have inotropic and anti-metastatic activities.
Patent ES-544231-A0 (ES)
IPC: C09D5/44
Filed: 1985-06-14
Abstract: Cathodic coating agents which are rendered water-dilutable by the addition of an acid, contain binder systems possessing basic nitrogen groups and may or may not contain pigments, dyes, fillers, solvents, antioxidants, other surface coating assistants and/or additional crosslinking components, the binder system containing sulfonate and/or phosphonate groups or the esters of these groups in an amount of from 0.05 to 3% by weight, and the preparation of such products. The novel coating agents are useful for the cathodic electrocoating of electrically conductive substrates.
Patent ES-546756-A0 (ES)
IPC: H02K3/22
Filed: 1985-09-06
Abstract: The connecting device has yokes (5, 6) brazed to the winding rod ends (1, 2), and the end surfaces of the yokes have distance pieces (10, 11, 12, 13). The hollow conductors (4) protrude beyond the solid part conductors (3) and are led through brazing plates (14, 15) which are brazed to both the hollow conductors (4) and the distance pieces (10, 11, 12, 13). Caps (16, 17) are placed over the brazing plates (14, 15) and brazed to the brazing plates (14, 15) in such a way that there is no leakage of liquid. The brazing points can be inspected at any time and, if necessary, improved because of the distance between the brazing plates (14, 15) and the rod end surface. The water chambers (20, 21) formed by the brazing plates (14, 15) and the caps (16, 17) are solidly connected to the winding rods (1, 2) and to the yokes (5, 6), so that no relative vibrations, which can damage the hollow conductors, can occur. The water chambers (20, 21), which are expensive in manufacture, do not depend on the rod geometry. The whole of the variance is provided by the brazing plates (14, 15) which are relatively simple to manufacture.
Patent ES-549118-A0 (ES)
IPC: C07C59/64
Filed: 1985-11-21
Abstract: A new process for the optical resolution of racemic mixtures of  alpha -naphthyl-propionic acids of formula 
<CHEM>
 where R1 is an alkyl group, straight or branched, having from 1 to 6 carbon atoms and R2 represents an hydrogen or an halogen atom. 
<??>This process comprises reacting a racemic mixture of a compound of formula II 
<CHEM>
 wherein R1 and R2 have the above seen meanings and R3 is a reactive group, with an optically active compound of formula
 R4-NH2      III
 wherein R4 is the residue of a primary or secondary alcohol which, taken with the NH2 radical, forms an optically active  beta -aminoalcohol, to give a pair of diastereoisomeric amides of
Patent FI-833212-A0 (FI)
Inventor: FREDETTE MAURICE C J
IPC: C01B11/02
Filed: 1983-09-08
Abstract: Chlorine dioxide for waste water treatment is formed by reaction of sodium chlorate, sodium chloride and sulphuric acid at high acidity while the reaction zone is subjected to subatmospheric pressure and spent reaction medium overflows from the reaction zone without crystallization of by-product sodium and sulphate. The subatmospheric pressure preferably is applied using a water eductor to which the water to be treated is fed, so that direct contact between the produced gases and the water to be treated is effected.
Patent FI-840608-A0 (FI)
Inventor: HARRIS MARTIN
IPC: C07D309/00
Filed: 1984-02-15
Abstract: Substituted 2-nitromethylene-tetrahydro-2H-1,3-thiazines of formula:in which n is 0 or 1; m is 0 or 1; X is oxygen or sulphur; and R is alkyl, alkenyl or alkynyl optionally substituted by one or more of the same or different substituents selected from halogen atoms and hydroxy, thiol, acyloxy, acylthio, alkoxy, alkoxyalkoxy, haloalkoxy, and optionally substituted phenyl groups; have useful pesticidal properties.
Patent FI-843202-A0 (FI)
Inventor: GEISSLER ULRICH
IPC: G03F7/004
Filed: 1984-08-14
Abstract: Disclosed is a radiation-polymerizable mixture which includes a polymerizable compound, a radiation-activatable polymerization initiator and a polymeric binder with lateral cross-linking groups of the formula -CH2OR, wherein R denotes a hydrogen atom or a lower alkyl group, a lower acyl group or a lower hydroxyalkyl group. The mixture is cured by heating after development. Also disclosed is a polymerizable copying material which includes a layer comprising the mixture and a process for producing a solder mask including a laminating step for laminating a photoresist layer which includes the layer.
Patent FI-853389-A0 (FI)
Inventor: BOSSLET KLAUS
IPC: A61K39/385
Filed: 1985-09-04
Abstract: The process entails either tumour cells which carry antigens which are bound by the monoclonal antibodies described in German Offenlegungsschrift 33 29 184 being dried or stabilised by a chemical treatment, or antigens being isolated from human cells using these monoclonal antibodies, and converted into a therapeutic agent, adding neuraminidase where appropriate.
Patent FI-904377-A0 (FI)
Inventor: KUHN WERNER
IPC: C25D3/62
Filed: 1990-09-05
Abstract: Yellow to rose-colored gold alloy coatings with copper and silver are obtained from stable galvanic baths with a pH of 8.5 to 11 containing, 1 to 15 g/liter gold as potassium gold (I) cyanide, 5 to 50 g/liter copper as potassium copper (I) cyanide, 0.05 to 5 g/liter silver as potassium silver (I) cyanide and dipotassium hydrogenphosphate as well as alkali cyanides in amounts of up to 10 g/liter and 0.1-1 mg/liter potassium selenocyanate.
Patent FI-905328-A0 (FI)
Inventor: RUPPEL REMY
IPC: B31F1/07
Filed: 1990-10-29
Abstract: The multi-ply sheet made up of at least two sheets of absorbent paper made of cellulose wool, whose weight per unit area is between 10 and 40 g/m<2>, obtained especially by a process consisting in goffering separately by calendering each of the said sheets according to a pattern consisting of protuberances distributed according to a first pitch (P1sm, P2sm) in a first direction and a second pitch (P1st, P2st) in a second direction forming a nonzero angle with the first, and whose end away from the plane of the ungoffered sheet comprises a bonding flattening, bonding, especially by adhesive bonding, the two sheets together via the said flattenings placed in at least partial coincidence, is characterised in that the pitches (P1sm, P2sm) in the said first direction are different and are related by the relationship 
<IMAGE>
 where L1 is a predetermined value corresponding to the measurement of a segment along which it is desired to guarantee the existence of at least one point capable of forming a bond between the two sheets, whatever the relative position of the two patterns. 
<IMAGE>
Patent FI-912102-A0 (FI)
Inventor: NIEMINEN KAUKO
IPC: C07C39/06
Filed: 1991-04-30
Abstract: The object of the invention is a new method for the purification of 2,6-diisopropyl phenol (propofol). The invention is characterized in that the raw product obtained from the alkylation of propene with phenol is crystallized at a temperature where propofol crystallizes but the isomers and other phenol derivatives formed in the reaction are still in liquid form, i.e. at a temperature of -25 to +18  DEG C, especially at -20 to -10  DEG C, without a solvent or using a suitable solvent, such as hexane or petrol ether.
Patent FI-913266-A0 (FI)
Inventor: SPADAFORA CORRADO
IPC: C12N15/87
Filed: 1991-07-05
Abstract: A process is described for the introduction of exogenous DNA into somatic and germ animal cells: the DNA, exogenous or modified according to known techniques of recombinant DNA, is introduced into the animal spermatozoa which are to be modified and said spermatozoa are employed for egg fertilization according to usual artificial fertilization techniques.
Patent FI-914652-A0 (FI)
Inventor: LOEPPOENEN JUSSI
IPC: H04W84/08
Filed: 1991-10-03
Abstract: PCT No. PCT/FI92/00263 Sec. 371 Date Jun. 3, 1993 Sec. 102(e) Date Jun. 3, 1993 PCT Filed Sep. 24, 1992 PCT Pub. No. WO/9307685 PCT Pub. Date Apr. 15, 1993.A call control method for a radio system, wherein a half-duplex type mobile station (MS1, MS2) is commanded so as to clear a call on the radio channel of a base station (BS), by transmitting a disconnect signal to the mobile station (MS1, MS2) over the radio channel, the mobile station leaving the radio channel upon receiving the disconnect signal. In order to ensure that the disconnect signal is received by the mobile station, the field intensity received by the base station (BS) on the radio channel is measured immediately after the transmission of the disconnect signal, and the radio channel is released for the next call only when the measured field intensity falls below a predetermined threshold value.
Patent FI-920861-A0 (FI)
Inventor: DE TAXIS DU POET PHILIPPE
IPC: C07K14/145
Filed: 1992-02-26
Abstract: The present invention relates to anti-thrombin polypeptides isolated from the leech Hirudinaria manillensis and to processes for their preparation. The polypeptides of the invention may be modified by way of amino acid extension at either or each end, and may be subjected to post-translational modification. The anti-thrombin polypeptides may be prepared by isolating them from the tissue or secretions of the leech Hirudinaria manillensis but they also may be synthetized by recombinant DNA methods. According to this latter aspect, the invention provides DNA sequences, expression vectors and host cell lines for the recombinant preparation of the polypeptides. The anti-thrombin polypeptides of the invention find an useful application in the treatment of venous thrombosis, vascular shunt occlusion and thrombin-induced disseminated intravascular coagulation. <IMAGE>
Patent FI-922830-A0 (FI)
Inventor: MCNICHOLS LARRY A
IPC: A61N1/32
Filed: 1992-06-17
Abstract: A method and apparatus are disclose for transdermal iontophoretic delivery of ionic species, such as a drug in ionic form, in which therapeutic, electrical pulses having controlled, distinctive, dual-segment waveform characteristics are applied which facilitate more efficient drug administration throughout each pulse. The therapeutic pulses are generated at a predetermined frequency and have a predetermined pulse width. A first pulse segment and a second pulse segment comprise each dual-segment, therapeutic pulse. The electrical attributes of each pulse segment, including amplitude and duration, are controlled to produce the desired, pulsed output waveform.
Patent FI-934271-A0 (FI)
Inventor: EARL HAROLD ADRIAN
IPC: C08L75/04
Filed: 1993-09-29
Abstract: This invention relates to a process for modifying lignocellulosic materials by a chemical treatment comprising treating the material sequentially or simultaneously with phthalic anhydride and a thermosetting resin at elevated temperature, and finally heat curing the phthalylated, resin-impregnated product. The lignocellulosic material so produced can be formed into shapes or moulds having excellent dimensional stability.
Patent FI-941172-A0 (FI)
Inventor: EVANS ROBERT E
IPC: C08J5/04
Filed: 1994-03-11
Abstract: Described are crimped acrylic fibers with a small diameter, a minimum aspect ratio (L/D) in the 20-50 range, and having a crimp of greater than about 3% so as to enhance the viscosity of polymers, resistance to gravity-induced slumping when applied to vertical surfaces, and mix stability, as well as provide matrix reinforcement and toughness. The crimped acrylic fibers are adapted to act as improved physical thixotropes in adhesives, sealants, coatings, paints, grouts, building materials and the like.
Patent FI-951587-A0 (FI)
Inventor: HANSSON STIG GUSTAV VILHELM
IPC: A61B17/58
Filed: 1995-04-04
Abstract: The present invention relates to an implant having a body (1) with at least one generally cylindrical part to be implanted into bone tissue. The cylindrical part is at least partly provided with threads (2) having a height between 0.02 mm and 0.20 mm. <IMAGE>
Patent FI-952606-A0 (FI)
Inventor: CHEVALLIER YVONICK
IPC: C08K3/36
Filed: 1995-05-29
Abstract: Novel silicas in the form of powder and spherical beads or granules. The silicas are characterized by having a specific CTAB surface of 100-140 m2/g, a small median diameter, following disaggregation by ultrasound means, and optionally, a porous distribution so that the porous volume occupied by the pores whose diameter is 175-275  ANGSTROM  is less than 55% of the porous volume occupied by the pores having diameters of 400  ANGSTROM  or less. The invention also concerns a method for the preparation of said silicas and their use as reinforcing fillers for elastomers.
Patent FI-956261-A0 (FI)
Inventor: NEUMEYER JOHN L
IPC: A61K51/00
Filed: 1995-12-27
Abstract: An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula:    <IMAGE>   wherein R=a CnH2n+1 group where n=0-6, an alkenyl group, a monofluoroalkyl group including nF where n=18 or 19, or a mCnH2n+1 group where n=1-6 and where m=11 or 14 for at least one mC; R'=a CnH2n+1 group where n=0-6, a p-iodophenylmethyl group, a p-iodophenylethyl group, a phenylmethyl group, or a phenylethyl group; X=an isotope of F, an isotope of Cl, an isotope of Br, an isotope of I, CH3, or Sn(R''1R''2R''3); R''1=a CnH2n+1 group where n=1-6, or an aryl group; R''2=a CnH2n+1 group where n=1-6, or an aryl group; R''3=a CnH2n+1 group where n=1-6, or an aryl group; and Y=H only if X is an isotope of I, or R' is a p-iodophenylmethyl group, or R' is a p-iodophenylethyl group, else Y=an isotope of I. Related analogs are also provided. Additionally, a precursor of a radiolabled neuroprobe and a kit for preparing the iodinated neuroprobe are provided.
Patent FI-970434-A0 (FI)
Inventor: HAMORI TAMAS
IPC: C07D491/056
Filed: 1997-01-31
Abstract: PCT No. PCT/DE95/01029 Sec. 371 Date Apr. 23, 1997 Sec. 102(e) Date Apr. 23, 1997 PCT Filed Jul. 28, 1995 PCT Pub. No. WO96/04283 PCT Pub. Date Feb. 15, 1996New 3-substituted 3H-2,3-benzodiazepine derivatives of general formula I    <IMAGE>  (I)  in which R1, R2, R3, R4, R5, R6, R7 and n have the meanings indicated in the description, their production as well as their use as pharmaceutical agents are described.\!
Patent FI-970701-A0 (FI)
Inventor: MUELLER WALTER
IPC: A61K9/70
Filed: 1997-02-19
Abstract: PCT No. PCT/EP95/03201 Sec. 371 Date Jun. 7, 1996 Sec. 102(e) Date Jun. 7, 1996 PCT Filed Aug. 12, 1995 PCT Pub. No. WO96/05814 PCT Pub. Date Feb. 29, 1996A transdermal therapeutic system comprising the active substance estradiol and having a layered structure of a backing layer which is impermeable to active substances and moisture, and active substance-containing matrix, and, if necessary, a removable protective layer covering the matrix, is characterized by the fact that the matrix comprises glycerol either comprising a maximum of 1%-wt. of water or being substantially free from water.
Patent IL-57993-A0 (IL)
Title: Insect attractant
IPC: A01N37/02
Filed: 1979-08-07
Abstract: 1. A composition for attracting and destroying Agrotis segetum containing Z-(5)-decenyl acetate in combination with usual auxiliaries and carrier substances.
Patent IL-76138-A0 (IL)
Title: Sucralfate suspension
IPC: A61K47/02
Filed: 1985-08-19
Abstract: The invention relates to formulations in the form of suspensions containing sucralfate, characterized in that they contain, based on the sucralfate, 1-5% by weight of xanthan gum and 1-12.5% by weight of at least one peptiser.
Patent IL-82997-A0 (IL)
Title: Method for epimerizing an optically active benzyl alcohol derivative
IPC: C07C233/22
Filed: 1987-06-25
Abstract: A method for epimerizing an optically active benzylalcohol derivative of the formula: <CHEM> wherein ZO is a protected or unprotected hydroxy group, is disclosed.   Said epimerization can be conducted by the steps of:   (a) condensing said optically active benzylalcohol derivative (I) or a salt thereof with a caboxylic acid compound of the formula:  R<1>COOH (II) wherein R<1>CO is an acyl group, or a reactive derivative thereof to give an optically active N-acylbenzylalcohol derivative of the formula: <CHEM>  wherein R<1>CO and ZO are the same as defined above; (b) subjecting the optically active N-acylbenzylalcohol derivative (III) to intramolecular cyclization in the presence of a thionyl halide; and (c) treating the product with an alkali agent. )
Patent IL-86583-A0 (IL)
Title: Vaccine containing a derivative of a microbe and method for the production thereof
IPC: A61K/
Filed: 1988-05-31
Abstract: This invention provides a vaccine for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of a pathogenic microbe said derivative being substantially incapable of producing functional adenylate cyclase and cyclic AMP receptor protein. The invention also provides a vaccine for the immunization of a vertebrate and invertebrate comprising a virulent derivative of a pathogenic microbe said derivative being substantially incapable of producing functional adenylate cyclase and cyclic AMP receptor protein while being capable of expressing a recombinant gene derived from a pathogen of said vertebrate to produce and antigen capable of inducing an immune response in said vertebrate against said pathogen.
Patent IL-98033-A0 (IL)
Title: Pharmaceutical compositions including a non-steroidal anti-inflammatory drug and a prostaglandin
IPC: A61K9/24
Filed: 1991-05-02
Abstract: A pharmaceutical composition including a core of an NSAID selected from diclofenac and piroxicam which core is surrounded by a mantle coating of a prostaglandin, wherein an intermediate coating can be present between the NSAID core and prostaglandin mantle coating.
Patent IL-103262-A0 (IL)
Title: Crystalline etoposide 4'-phosphate diethanolate
IPC: A61P35/00
Filed: 1992-09-23
Abstract: The present invention provides temperature stable crystalline etoposide 4'-phosphate diethanol solvate, and a process for its preparation.
Patent IL-106167-A0 (IL)
Title: 24-cyclopropane vitamin d derivatives and pharmaceutical compositions containing the same
IPC: C07C401/00
Filed: 1993-06-29
Abstract: Vitamin D2 analogs in which a cyclopropane ring is introduced onto the 24-carbon of the side chain of 1 alpha ,25-dihydroxyvitamin D2 and 1 alpha -hydroxyvitamin D2. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1 alpha ,25-dihydroxy-vitamin D3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.
Patent IL-108173-A0 (IL)
Title: 2-Amino-6, 7-dihydroxy-4-thiaheptanoic acid derivatives, production and use thereof
IPC: C07K5/083
Filed: 1993-12-24
Abstract: A compound of the formula: <CHEM> wherein each of R<1> and R<2> is hydrogen or aliphatic acyl, A is amino which may be protected, X is an amino acid sequence consisting of 1 to 10 amino acid residues which contain at least one amino acid residue having a water-solubility enhancing group, or a salt thereof has an activity of remarkably improving hematopoietic disorder and is useful as an immuno-stimulating agent or an agent for treating thrombocytopenia.
Patent IL-127488-A0 (IL)
Title: Frozen food with antifreeze peptides
IPC: A23G9/44
Filed: 1997-07-04
Abstract: A process for the production of a frozen food product comprising AFP, wherein the conditions are chosen such that the ice-crystals in the product have an aspect ratio of from 1.9 to 3.
Patent IL-133902-A0 (IL)
Title: Smooth muscle controller
IPC: A61N1/20
Filed: 1997-07-16
Abstract: A method for promoting the healing of a lesion in a smooth muscle (200), comprises selecting a smooth muscle portion having a lesion, applying a non excitatory electric filed (210) to the portion, which reduces the mechanical activity of the portion.
Patent IL-137808-A0 (IL)
Title: Erythropoietin liposomal dispersion
IPC: A61K47/18
Filed: 1999-02-12
Abstract: The present invention relates to a liposome based formulation of erythropoietin comprising:     (a) an effective amount of an erythropoietin;   (b) a lipidic phase comprising:     (i) lecithin or hydrogenated lecithin; (ii) optionally, a charged electropositive or electronegative lipid compound; and (iii) cholesterol or a derivative thereof selected from cholesterol esters, polyethylene glycol derivatives of cholesterol (PEG-cholesterols), and organic acid derivatives of cholesterols; and       (c) a phosphate buffer.   The liposome based parenteral dosage form of the invention is prepared by means of an ethanol injection technique. The composition avoids the need for use of human serum albumin and exhibits superior stability.
Patent IL-139050-A0 (IL)
Title: Fertilizer granulation method
IPC: C05G5/12
Filed: 1999-04-08
Abstract: Fertilizer granulation method for incorporating urea directly into the matrix of fertilizer pellets. The process involves introducing the urea in a liquid form into the matrix and then progressively cooling the mixture of pellet and urea to recrystallize the urea within the matrix of the pellet. The result is a substantially harder particle relative to pretreatment hardness, reduced solubility for longer lasting pellets and substantially reduced dust and other handling problems of the formed pellets.
Patent IL-158015-A0 (IL)
Title: Process for the preparation of alkyl-n-(3-dimethylamino) alkylcarbamates
IPC: C07C269/04
Filed: 2002-04-18
Abstract: This invention relates to a process for the preparation of alkyl-N-(3-dimethylamino)alkylcarbamates by reacting an alkyl-chloroformate in an alcohol.
Patent IL-190702-A0 (IL)
Title: Submersible vehicle
IPC: B63H1/16
Filed: 2008-04-08
Abstract: A submersible vehicle having an outer hull which defines a hull axis and appears substantially annular when viewed along the hull axis, the interior of the annulus defining a duct which is open at both ends so that when the vehicle is submerged in a liquid, the liquid floods the duct. The vehicle further comprises a buoyancy control system. Various methods of deploying and using the vehicle are described.
Patent IL-195449-A0 (IL)
Title: Device, assembly and method for cold treating a tissue
Filed: 2008-11-23
Abstract: The invention relates to a device for cold treating a tissue. The invention also relates to an assembly of such a device and a container comprising a cryogenic liquid, such as a spray can. The invention further relates to a method for cold treating a tissue.