Patent SG-11201803934Y-A (SG)
Title: Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies
Inventor: PATEL DIMKI S
IPC: C12N15/62
Filed: 2016-11-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau irestYlid (43) International Publication Date ..... ..sr ,„,„01 18 May 2017 (18.05.2017) WIPO I PCT (10) WO International Publication Number 111111111111311111111111111111111111111111111111111111111111111111111311111111111111111 2017/083750 Al (51) International Patent Classification: KW, C07K 14/52 (2006.01) A61K 48/00 (2006.01) MG, A61K 38/16 (2006.01) C12N 15/62 (2006.01) OM, SC, (21) International Application Number: TN, PCT/US2016/061668 ZW. (22) International Filing Date: (84) Designated 11 November 2016 (11.11.2016) kind (25) Filing Language: English GM, TZ, (26) Publication Language: English TJ, (30) Priority Data: DK, 62/254,139 11 November 2015 (11.11.2015) US LV, SM, KZ, LA, LC, LK, LR, LS, MK, MN, MW, MX, MY, PA, PE, PG, PH, PL, PT, SD, SE, SG, SK, SL, SM, TR, TT, TZ, UA, UG, States (unless otherwise of regional protection available): KE, LR, LS, MW, MZ, UG, ZM, ZW), Eurasian (AM, TM), European (AL, AT, EE, ES, FI, FR, GB, GR, MC, MK, MT, NL, NO, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, LU, LY, MA, MD, ME, MZ, NA, NG, NI, NO, NZ, QA, RO, RS, RU, RW, SA, ST, SV, SY, TH, TJ, TM, US, UZ, VC, VN, ZA, ZM, indicated, for every ARIPO (BW, GH, NA, RW, SD, SL, ST, SZ, AZ, BY, KG, KZ, RU, BE, BG, CH, CY, CZ, DE, HR, HU, IE, IS, IT, LT, LU, PL, PT, RO, RS, SE, SI, SK, (71) Applicant: INTREXON CORPORATION [US/US]; GW, KM, ML, MR, NE, SN, TD, 20358 Seneca Meadows Pkwy, Germantown, Maryland 20876 (US). Declarations (72) Inventors: PATEL, Dimki S ; 20358 Seneca Meadows as under Rule 4.17: to applicant's entitlement to TG). apply for and be granted a Pkwy, Germantown, Maryland 20876 (US). PATEL, Amit patent (Rule 4.17(ii)) N.; 1040 Chartwell Ct., Salt Lake City, Utah 84103 (US). — as earlier application (Rule 4.17(iii)) to the applicant's entitlement to claim the priority of the (74) Agent: GIRINATH, Prashant; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, California 94304 Published: (US). — with international search report (Art 21(3)) Designated States indicated, (81) (unless otherwise for every _ before the expiration of the time limit for amending the kind of national available): AE, AG, AL, AM, protection claims and to be republished in the event of receipt of AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, amendments (Rule 48.2(h)) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, with sequence listing part of description (Rule 5.2(a)) HN, HR, HU, ID, IL, IN, IR, IS, KE, KG, KN, KP, KR, JP, (54) Title: COMPOSITIONS AND METHODS FOR EXPRESSION OF MULTIPLE BIOLOGICALLY ACTIVE POLY- PEPTIDES FROM A SINGLE VECTOR FOR TREATMENT OF CARDIAC CONDITIONS AND OTHER PATHOLOGIES ORI ter -2 Car d iac Il .4t C un N en cc o FIG. I IN Il C (57) : The present invention provides compositions and methods useful for treating disorders amenable to therapy via intro - N duction of multigenic expression vectors. More particularly, the invention provides vectors and polynucleotides encoding poly- 0 peptides for treatment of cardiac disorders wherein said polypeptides may comprise a cytokine, a chemokine, and/or an angiogenic ,..I polypeptide, or functional derivatives thereof. Also provided, as compositions of the invention, are linkers useful for connecting and expressing functional (biologically active) polypeptides from single, multigenic-expression constructs.