Patent SG-11201906319X-A (SG)
Title: Compositions and methods for the depletion of cd137+ cells
Inventor: HARTIGAN ADAM
IPC: C12N5/00
Filed: 2018-01-19
Abstract: N QC N 1-1 00 O 1-1 r•i C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIP0 I PCT omit VIII °nolo 01110111 Ho (10) International Publication Number WO 2018/134787 A3 25001 (51) International Patent Classification: C07K 16/28 (2006.01) Cl 2N 5/00 (2006.01) A61K 47/68 (2017.01) (21) International Application Number: PCT/IB2018/050365 (22) International Filing Date: 19 January 2018 (19.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/448,741 20 January 2017 (20.01.2017) US 62/595,977 07 December 2017 (07.12.2017) US (71) Applicant: MAGENTA THERAPEUTICS, INC. [US/US]; 50 Hampshire Street, 8th Floor, Cambridge, Massachusetts 02139 (US). (72) Inventors: HARTIGAN, Adam; 84 Harvard Avenue, Apt. 2, Brookline, Massachusetts 02446 (US). BOITANO, An- thony; 27 Evelyn Road, Newton, Massachusetts 02468 (US). COOKE, Michael; 135 University Road, No. 1, Brookline, Massachusetts 02445 (US). HOBAN, Megan D.; 399 High Street, Unit 1, Medford, Massachusetts 02155 (US). PALCHAUDHURI, Rahul; 46 Springfield Street, Apt. 2, Somerville, Massachusetts 02143 (US). (74) Agent: COWLES, Cristin; Womble Bond Dickinson (US) LLP, Two International Place, Boston, Massachusetts 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: COMPOSITIONS AND METHODS FOR THE DEPLETION OF CD137+ CELLS 0 nIgG1 O BBK2-mIgG1 EC50 = 35 pM O \"T 10 12 10-11 '0-10 0 10-8 10 -7 CONCENTRATION LOG [M] FIG. 1A (57) : of the Invention The invention provides methods of preventing and treating graft-versus-host-disease and autoimmune diseases, such as those arising from transplant therapy, by selective depletion of hematopoietic cells through the use of antibody-drug conjugates and ligand-drug conjugates that specifically bind CD137. The compositions and methods described herein can be used to treat a variety of pathologies, including stem cell disorders and other blood conditions. [Continued on next page] WO 2018/134787 A3 MIDEDIMOMOIDEIREEMOMMIIHOMMOHMIN (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE (88) Date of publication of the international search report: 04 October 2018 (04.10.2018)