Patent SG-11201811704S-A (SG)
Title: Dosage regimens of lingo-1 antagonists and uses for treatment of demyelinating disorders
Inventor: CADAVID DIEGO
IPC: A61K39/395
Filed: 2017-07-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111101111 0 DOI HIM 011101 0 0111111 01110011H111111111111111111111111111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/013714 Al 18 January 2018 (18.01.2018) WI P0 I P C T (51) International Patent Classification: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, A61K 39/395 (2006.01) G01N 33/50 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (21) International Application Number: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, PCT/US2017/041757 KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (22) International Filing Date: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 12 July 2017 (12.07.2017) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 62/362,032 13 July 2016 (13.07.2016) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 62/394,094 13 September 2016 (13.09.2016) US TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 62/412,582 25 October 2016 (25.10.2016) US EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 62/486,217 17 April 2017 (17.04.2017) US MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 62/512,510 30 May 2017 (30.05.2017) US TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (71) Applicant: BIOGEN MA INC. [US/US]; 225 Binney St, Cambridge, MA 02142 (US). Declarations under Rule 4.17: (72) Inventors: CADAVID, Diego; c/o Biogen MA Inc., 225 — as to applicant's entitlement to apply for and be granted a Binney Street, Cambridge, MA 02142 (US). XU, Lei; c/o patent (Rule 4.17(0 Biogen MA Inc., 225 Binney Street, Cambridge, MA 02142 — as to the applicant's entitlement to claim the priority of the (US). XU, Lin; c/o Biogen MA Inc., 225 Binney Street, earlier application (Rule 4.17(iii)) Cambridge, MA 02142 (US). Published: (74) Agent: BRENNAN, Jack et al.; Fish & Richardson P.C., — with international search report (Art. 21(3)) P.O. Box 1022, Minneapolis, MN 55440-1022 (US). — with sequence listing part of description (Rule 5.2(a)) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, Title: DOSAGE REGIMENS OF LINGO-1 ANTAGONISTS AND USES FOR TREATMENT OF DEMYELINATING = (54) DISORDERS End of End of study/ treatment follow-up AON onset Baseline Trragulaggi4 whe visit visit Day-2b Day 1 W4 WS W12 W16 W20 W24 W32 Screen 1 ,--- : (pretreatrn 4 ent) 1-1 cu 0 3-5 days IV 71- steroidsa 1-1 IN C 4 \") 1-1 aFor participants with AON who had not been already treated. 0 --.... ,-, © ei I. I (57) : Dosage regimens, methods, compositions and kits are described herein useful for detecting and/or treating a CNS demyelinating disease.