baber/WOPTO huggingface dataset:
Patent JP-4077861-B2 (JP)
IPC: A61K39/00
Filed: 2006-12-26
Granted: 2008-04-23
Abstract: The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.
Patent JP-4652328-B2 (JP)
IPC: A61B18/12
Filed: 2004-04-29
Granted: 2011-03-16
Abstract: An apparatus for delivering energy to a target site within bone includes a hollow needle extending from a handle that terminates in a tissue piercing distal tip. A drill within a lumen of the needle is extendable beyond the distal tip, and includes a cutting element and an electrically conductive region. An RF generator may be coupled to the drill for delivering energy to the electrically conductive region, and a driver or actuator may be coupled to the drill for rotating and/or advancing the drill axially. During use, the needle is inserted through a patient's skin to a hard tissue structure, e.g., a bone, including a target site therein, e.g., a tumor. The drill is advanced from the needle, a hole is drilled into the bone until the drill reaches the tumor, and electrical energy is delivered via the electrically conductive region to destroy the tumor.
Patent JP-5026787-B2 (JP)
IPC: A61K38/095
Filed: 2004-07-15
Granted: 2012-09-19
Abstract: The invention relates to an oral, multiparticle pharmaceutical dosage form containing pellets, the size of which ranges from 50 to 2500 μm and which essentially consist of: a) an inner matrix layer containing an active substance which is a peptide or a protein, including the derivatives or conjugates thereof, and which is embedded in a matrix consisting of a polymer with mucoadhesive effect, and b) an outer film coating essentially consisting of an anionic polymer or copolymer, which can be optionally formulated with pharmaceutically conventional adjuvants, more particularly softening agents.
Patent JP-4498355-B2 (JP)
IPC: A61B17/00
Filed: 2004-07-23
Granted: 2010-07-07
Abstract: The invention relates to an adjustable stomach band with a rigid back and a chamber, arranged on the stoma side of the back, for control of stoma constriction by means of introduction or removal of fluid from the chamber. According to the invention, such a stomach band with a preferably automatic setting of the stoma constriction, depending on the food intake, is possible, whereby a second chamber is provided to the stoma side of the back, directly connected to, or cooperating with the first chamber, such that the control of the stoma constriction is achieved by means of displacing the fluid between the chambers or between a reservoir and the stoma-constricting chamber. An auto-regulation can be achieved, whereby a second chamber is embodied as sensor for recording a pressure rise in the stomach and the control of the stoma constriction is achieved depending on the recorded pressure by means of displacement of the fluid from the chamber, or from the reservoir into the stoma-constricting chamber.
Patent JP-4452718-B2 (JP)
IPC: B29D30/40
Filed: 2004-08-24
Granted: 2010-04-21
Abstract: An apparatus and process are used to make tape which can be used as cap plies, breakers and reinforcement in the carcass of tires. The tape is made by dipping a plurality of single end cords in a solvent-based cement. The cords are converged before entering the dip pan so that they are fixed in a single plane when they are dipped. The cement, which contains solvent and an elastomeric composition, is dried so that the majority of the solvent evaporates. The elastomeric composition remains, encapsulating the cords, thereby forming the tape.
Patent JP-4568722-B2 (JP)
IPC: C07K16/00
Filed: 2004-09-02
Granted: 2010-10-27
Abstract: The present invention provides a method for controlling the partitioning of a recombinant protein between the supernatant and the periplasm in E. coli host cell cultures wherein expression of the recombinant protein by said cells is under the control of an inducible system, which method comprises: a) providing an E. coli host cell culture b) changing the growth rate of the E. coli host cells c) inducing expression of the recombinant protein wherein steps (b) and (c) can be performed in any order or simultaneously; and subsequently d) determining the yield of recombinant protein in the culture supernatant and the E. coli host cell periplasm e) comparing the yield determined in step (d) with the yield determined when at least one other growth rate has been used in step (b) f) selecting a growth rate from the comparison made in step (e) in which the partitioning of the recombinant protein between the supernatant and the periplasm is most suited to the primary recovery of the recombinant protein.
Patent JP-4904162-B2 (JP)
IPC: B25B23/04
Filed: 2004-12-02
Granted: 2012-03-28
Abstract: A curved screwstrip comprising in combination a plastic holding strap and a plurality of threaded fasteners. The plastic holding strap has a greater mass in its top half than in its bottom half so that shrinking after extrusion will tend to have the holding strap adopt a preferred curved configuration.
Patent JP-4468961-B2 (JP)
IPC: G06F19/00
Filed: 2005-02-09
Granted: 2010-05-26
Abstract: Idle speed stability is imparted to a compression ignition engine by processing data values for actual engine speed and desired engine speed to yield a data value for engine speed error; processing ( 22 ) the data value for engine speed error according to a governor algorithm for yielding a data value for a mass fuel rate for governed fueling of the engine; c) processing ( 24 ) the data value for mass fuel rate for governed fueling of the engine and the data value for actual engine speed to yield a data value for a quantity of fuel to be injected into an engine cylinder during an ensuing stroke of a piston within the cylinder; and d) injecting ( 30 ) that quantity of fuel into the cylinder during that stroke.
Patent JP-5026825-B2 (JP)
IPC: H01L21/68
Filed: 2007-03-14
Granted: 2012-09-19
Abstract: <P>PROBLEM TO BE SOLVED: To provide an alignment apparatus capable of continuously maintaining an effect of positioning a plate-like member, a conveying apparatus capable of conveying the plate-like member while maintaining its position, and a sheet pasting apparatus comprising their apparatuses.  <P>SOLUTION: The alignment apparatus 11 comprises a base member 20; a supporter 21 to be attachably/detachably supported by the base member 20; a first positioning means 22 for positioning the supporter 21 on the base member 20; a second positioning means 24 for positioning a semiconductor wafer W on a placing surface 21A of the supporter 21. The semiconductor wafer W can be conveyed by the conveying means 13 together with the supporter 21, and the supporter 21 is supported on a table member 12 via a third positioning means 45. An adhesive sheet S is pasted on the semiconductor wafer W supported by the table member 12 via a pasting means 15.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Patent JP-4811354-B2 (JP)
IPC: C30B19/04
Filed: 2007-06-11
Granted: 2011-11-09
Abstract: 5 to 30 at % of Ti and 1 to 20 at % of Sn or 1 to 30 at % of Ge are added to an Si melt, and SiC single crystal are grown from SiC seed crystal by holding the SiC seed crystal immediately beneath the surface of the Si melt in a graphite crucible while maintaining temperature gradient descending from the inner side of the Si melt to the surface of the melt.
Patent JP-4320381-B2 (JP)
IPC: C07K16/28
Filed: 2007-07-17
Granted: 2009-08-26
Abstract: The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.
Patent JP-4903646-B2 (JP)
IPC: G03G15/00
Filed: 2007-07-27
Granted: 2012-03-28
Abstract: <P>PROBLEM TO BE SOLVED: To provide a sheet laminator and an image forming apparatus, capable of carrying a first sheet and a second sheet in such a way as to be capable of skewing so that both sheets meet each other to be bonded at a skewed position, while they are prevented from being bonded to each other at an undesired timing.  <P>SOLUTION: On carrying upstream side of a bonding section where the first sheet and the second sheet to be bonded to each other by a bonding means converge in the middle of a carrying path and bonded together, a direction regulation means is provided to be abutted on either the first sheet or the second sheet on the opposite side to the surface to be bonded almost up to the bonding section for regulating the advance direction.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Patent JP-4590571-B2 (JP)
IPC: C09J7/10
Filed: 2007-12-12
Granted: 2010-12-01
Abstract: The invention concerns an adhesive film for stacking chips which enables chips to be stacked in layers without using a separate spacer usually provided to keep a given distance between wires of an upper chip and a lower chip to have the same area. The adhesive film of the invention has an intermediate adhesive layer of thermoplastic phenoxy resin on both side of which a thermosetting adhesive layer of epoxy resin is placed, respectively, to make a three-layer structure, the thermoplastic phenoxy resin comprising UV curable small molecule compounds. The adhesive film of the invention is a multi-layered adhesive film produced by a method of comprising the steps of achieving compatibility on an interface between the thermosetting epoxy resin and thermoplastic phenoxy resin and then directly forming a phenoxy film of a high elastic modulus through UV curing in an adhesive film. With such a configuration, the adhesive film for stacking semiconductor chips according to the invention enables the semiconductor silicone chips to be stacked in 3 or more layers without using a separate spacer between chips in order to keep a wire distance between upper and lower chips in stacking the chips. With the configuration, it is advantageous that reliability of semiconductors is not lowered because adhesiveness is kept despite of a repeated process of stacking chips subject to high temperature.
Patent JP-5642332-B2 (JP)
IPC: G09B23/28
Filed: 2007-12-14
Granted: 2014-12-17
Abstract: Display unit comprising input means for an oscillating signal (having an amplitude and a frequency, i.e. chest compression signal from a CPR session), a first indicator adapted to be activated when the amplitude reaches a maximum value, a second indicator adapted to be activated when the amplitude reaches a minimum value, a third indicator adapted to be activated partially or fully depending on amplitude, a fourth indicator adapted to be activated by a secondary signal derived from the input signal's frequency and a fifth indicator adapted to be activated when there is no input signal during a predetermined period of time. The first and the second indicators have different states (brightness) depending on the number of occurrences of a maximum respectively minimum amplitude over a period of time. The fourth indicator comprises a central zone adapted to be activated when the signal's frequency lies within a maximum and minimum value and two sides zones activated when the signal frequency exceeds the maximum and minimum value, respectively.
Patent JP-4380767-B2 (JP)
IPC: F16H61/66
Filed: 2007-12-27
Granted: 2009-12-09
Abstract: A hydraulic control system of continuously variable transmission includes: a first sheave pressure regulating valve (17) that regulates a line pressure (Pl), which is used for hydraulic control as a source pressure, to obtain a first sheave pressure (Pin); a fail-safe valve (19) that selects and outputs any one of the first sheave pressure (Pin) or a fail-safe hydraulic pressure (second sheave pressure Pout) that is applied to a drive pulley (21) at the time of a failure due to an excessive first sheave pressure (Pin) to the drive pulley (21); and a first regulator valve (12) and a second regulator valve (13) that regulate the line pressure (Pl). An output pressure (Psf) of the fail-safe valve (19) is supplied to the first and second regulator valves (12 and 13) in a feedback manner as a drive pulley (21) side hydraulic pressure to thereby regulate the line pressure (Pl).
Patent JP-4331777-B2 (JP)
IPC: H04L12/413
Filed: 2005-02-01
Granted: 2009-09-16
Abstract: A communications system for a motor vehicle, including a plurality of electrical components, a data bus structure to which the components are connected in order to transmit information among the components, and a power line structure to which the components are connected in order to be supplied with power. The information is transmitted in successive cycles over the data bus structure, each cycle including at least one time window for transmitting information at specific points in time and at least one event window for transmitting information in response to specific events. The communications system includes an arrangement for redundantly transmitting information which merely transmits the information transmitted in the at least one time window over the data bus structure at least partially over the power line structure as well.
Patent JP-5008565-B2 (JP)
IPC: A61K6/00
Filed: 2005-05-23
Granted: 2012-08-22
Abstract: Accurate means of dosing with a compressed, segmented pharmaceutical tablet, and tablettes formed from said tablets, is disclosed.
Patent JP-5036556-B2 (JP)
IPC: H02J7/02
Filed: 2006-01-10
Granted: 2012-09-26
Abstract: The invention relates to a method for the balanced charging of n cells which form a lithium-ion or lithium-polymer battery and which are connected in series. The invention is characterised in that the method consists in monitoring the charge levels of the different cells (1) from the moment (t1) following the beginning of the battery (2) charging operation until said operation ends normally or is interrupted; and, as a function of the pre-evaluation of said charge levels, either powering of all the cells (1) uniformly or balancing the cell (1) charge levels by powering same in a differentiated manner as a function of the current charge levels thereof.
Patent JP-4977035-B2 (JP)
IPC: A61P35/00
Filed: 2006-05-04
Granted: 2012-07-18
Abstract: Use of at least one oligonucleotide with a length of from 8 to 30 nucleotide building blocks for manufacturing a pharmaceutical preparation for the prophylaxis and/or the treatment of diseases, that are modulated by TGF-beta1, TGF-beta3, VEGF, interleukin-10, c-jun, c-fos, and/or prostaglandin E2 in a mammal, wherein said oligonucleotide hybridizes with a messenger RNA of a TGF-beta1, TGF-beta3, VEGF, interleukin-10, c-jun, c-fos and/or prostaglandin E2 gene and wherein said preparation comprises said oligonucleotide in a concentration of about 1 microM to about 25 microM.
Patent JP-5274048-B2 (JP)
IPC: G06Q40/04
Filed: 2008-02-25
Granted: 2013-08-28
Abstract: <P>PROBLEM TO BE SOLVED: To provide a buying and selling ordering program for sending a buying and selling order of a financial commodity from a computer operated by an investor to a securities company system through a network while preventing an incorrect order resulting from a mistake of input operation and reducing the load for input operation of order conditions.  <P>SOLUTION: An order input cell for inputting an order quantity is set on both sides of a board for displaying quotation information for each offered price-based price. When the order quantity is input to the order input cell, order data in which buying or selling, a price designated as a limit price, and the order quantity are automatically designated as order conditions from the buying or selling and price associated with the input cell. Therefore, the input operation of the order conditions can be simplified to reduce the operation load therefor, and further since the order conditions can be visually acquired on the board screen, an incorrect order resulting from a mistake of input operation can be prevented.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Patent JP-5311539-B2 (JP)
IPC: C12N15/09
Filed: 2008-03-14
Granted: 2013-10-09
Abstract: <P>PROBLEM TO BE SOLVED: To provide a new technique capable of simultaneously conducting enhancing the disease injury resistance and environmental stress resistance of a plant and promoting the plant's growth.  <P>SOLUTION: By suppressing the function of SIB A gene in a plant, it has been found that the disease injury resistance and environmental stress resistance of the plant can be enhanced and the growth of the plant can be promoted as well, significantly as compared to the cases with wild-type plants.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Patent JP-5297059-B2 (JP)
IPC: E04G21/16
Filed: 2008-03-24
Granted: 2013-09-25
Abstract: <P>PROBLEM TO BE SOLVED: To provide a heavy load lifting device capable of surely lifting a heavy load stably to any height in a short time and of selecting the lifting height optionally.  <P>SOLUTION: The heavy load lifting device comprises a first strut 1 vertically affixed to a base 4, a second strut 2 liftably assembled in the first strut 1, a third strut 3 which is liftably assembled in the second strut 2 and on which a heavy load is placed, a first lifting means 5 for lifting the second strut 2, and a second lifting means 11 for lifting the third strut 3 when the second strut 2 is lifted. The second lifting means 11 comprises first pulleys 12A, 12B attached to the upper inside of the second strut 2, second pulleys 13A, 13B attached to the lower outside of the third strut 3, third pulleys 14A, 14B attached to the upper outside of the third strut 3, and wire ropes 15A, 15B having one end affixed to the base 4 and the other end affixed to the base 4 with the first, second, and third pulleys interposed therebetween. The third strut 3 is lifted through the second lifting means 11 when the second strut 2 is lifted by the first lifting means 5.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Patent JP-5344842-B2 (JP)
IPC: E06B9/54
Filed: 2008-03-31
Granted: 2013-11-20
Abstract: <P>PROBLEM TO BE SOLVED: To provide a drawing type sash window which makes a mesh member stain-resistant by enabling the storage of the mesh member, and which brings about proper usability by bringing the opening/closing of the mesh member into synchronization with that of a sash.  <P>SOLUTION: A wire screen device 1 is built in a window frame 4 in which airtight pieces 49 forming an airtight line are provided on the indoor sides of inner and outer sashes 2 and 3, respectively; and a head 43 is provided with travel guide portions 41A and 41B exclusive to movable stiles constituting the wire screen device 1. The wire screen device 1 comprises: wire screen storage cases 5 and 5 which serve as wire screen storage sections arranged on the facing surfaces 40 of the window frame 4, facing sash stiles 20 and 30 of the inner and outer sashes 2 and 3, respectively; movable stiles 6 and 6 which are arranged between the cases 5 and 5 and the sash stiles 20 and 30, respectively, and which can follow the movement of the sash stiles 20 and 30, respectively; and the mesh member 7 which is housed in the wire screen storage cases 5 and 5, and the leading end side of which is attached to the movable stiles 6 and 6.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Patent JP-5305127-B2 (JP)
IPC: G03G15/08
Filed: 2008-03-31
Granted: 2013-10-02
Abstract: <P>PROBLEM TO BE SOLVED: To provide a developing apparatus for changing a height of a developer accumulated in the vicinity of a developer discharge port in response to the quantity of the developer within the apparatus, discharging the increased quantity of the developer when the quantity of the developer is increased within the apparatus, simplifying a constitution, and properly exchanging the developer within the apparatus, and an image forming apparatus with the developing apparatus.  <P>SOLUTION: A supply downstream end wall surface 80 is provided so as to accumulate the developer in the vicinity of the developer discharge port 94 within a supply/transfer path 9. The developer discharge port 94 is provided so as to pass the developer attaining the height of the developer discharge port 94 among the accumulated developer T accumulated on the supply downstream end wall surface 80. An opening width W as a horizontal width of the developer discharge port 94 is configured so as to prevent the developer from attaining a discharge port upstream end 94f even if the developer attains a discharge port downstream end 94e among both ends of the developer discharge port 94 in the horizontal direction when the height of the accumulated developer T is maximized.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Patent JP-4524764-B2 (JP)
IPC: G01N29/04
Filed: 2008-03-31
Granted: 2010-08-18
Abstract: An ultrasonic testing equipment of the present invention includes: an ultrasonic probe having a plurality of transducers arranged along a predetermined annular curved surface; a transmission/reception control unit that causes at least two transducers selected from the plurality of the transducers to transmit the ultrasonic waves to and receive the same from the tubular test object and a ultrasonic testing waveform display unit which displays ultrasonic testing waveforms received by the selected transducers radially corresponding to the propagation directions of the ultrasonic waves transmitted from and received by the selected transducers. The ultrasonic testing waveform display unit displays the ultrasonic testing waveforms radially with a point of time corresponding to an echo on an incident point of the ultrasonic wave to the tubular test object contained in the ultrasonic testing waveform as a beginning point and displays circles indicating points of time corresponding to the echo on the internal surface and/or the external surface of the tubular test object around the beginning point.
Patent JP-5120040-B2 (JP)
IPC: F16H25/22
Filed: 2008-04-14
Granted: 2013-01-16
Abstract: In a ball screw mechanism (15), a retainer (27) is provided between an outer circumference (20b) of a ball screw shaft (20) and an inner circumference (21b) of a ball nut (21) and has a plurality of retainer grooves (26) arranged in the circumferential direction for retaining a plurality of rolling balls (24). Each retainer groove (26) of the retainer (27) takes a form that allows the rolling balls (24) therein to move radially outward but restrains the rolling balls (24) therein from moving radially inward. Therefore, in the ball screw mechanism (15) and an electric power steering device (10) incorporating the same, the movement of the retainer (27) in radial directions can be restricted by the plurality of rolling balls (24) which are rolled along ball rolling grooves (20a) spirally formed respectively on the outer circumference of the ball screw shaft (20) and the inner circumference of the ball nut (21).