baber/WOPTO huggingface dataset:
Patent FI-853183-A0 (FI)
Inventor: URBAN FRANK JOHN
IPC: C07D491/107
Filed: 1985-08-19
Abstract: An improved process for preparing (4S)-6-fluoro-spiro-[chroman-4,4 min -imidazolidine]-2 min ,5 min -dione (sorbinil) or its (2R)-methyl derivative (2-methylsorbinil) is disclosed herein, starting from p-fluorophenol in each instance. The final products obtained have known pharmaceutical value as agents for the control of certain chronic diabetic complications. Key steps concerned with the process involve converting p-fluorophenol into the appropriate  beta -(4-fluorophenoxy)-alkane halide, followed by amidoalkylation with N-benzoyl or N-(lower alkanoyl)- alpha -hydroxyglycine to form an intermediate 2-amidoalkylated derivative thereof, and then dehydration and spiroalkylation of said intermediate by treatment with a dehydrating agent and a base to yield a spiroalkylated azlactone compound. The latter compound is then subsequently converted to the known 4-amino-6-fluorochroman-4-carboxylic acid or the novel (2R-methyl derivative thereof, both in the form of their hydrohalide acid addition salts, by employing acid hydrolysis and the intermediate spiro-amino acid hydrohalide salt is thereafter converted to the corresponding methyl or ethyl ester and resolved with  alpha -chymotrypsin to afford the desired (S)-methyl or (S)-ethyl ester. Treatment of either of these latter two esters with an alkali metal cyanate in an acid medium then effects conversion of same to the desired spiro-hydantoin ring compound. Alternatively, the spiro-amino acid hydrohalide salt can also be converted to the desired spiro-hydantoin ring compound in a known manner, involving a sequence of three reaction steps. The spiroalkylated azlactone compound of the instant invention, as well as the methyl and ethyl esters mentioned above, are themselves novel compounds and are valuable as synthetic intermediates in the process of this invention.
Patent FI-854150-A0 (FI)
Inventor: LORENZ ACHIM RUDOLPH
IPC: B65D65/12
Filed: 1985-10-23
Abstract: A multi-layered corrugated container (10) having at least one flat side (11) and having at least one foldable flap (13) attached at the fold line (14) to the flat side. In the past the fold line has been scored or crushed after the box is formed, and this represents an additional manufacturing step. To avoid this, the container of the present invention comprises a multi-layered sleeve with at least one flap (13) on one end of the sleeve and a fold line (14) separating the flap from the sleeve, the fold line comprising a strip (20) with no corrugations therein to permit the flap to be bent about the fold line.
Patent FI-862764-A0 (FI)
Inventor: GRELL WOLFGANG
IPC: C07D295/04
Filed: 1986-06-30
Abstract: 1. Phenylacetic acid derivatives of general formula  see diagramm : EP0208200,P24,F1  wherein R1 represents a pyrrolidino, piperidino, 4-methylpiperidino, 3-methyl-piperidino, 3,3-dimethyl-piperidino, 3,5-dimethyl-piperidino or hexamethyleneimino group, R2 represents a hydrogen, fluorine or chlorine atom or a methyl or methoxy group, R4 represents a hydrogen atom, an alkyl group with 1 to 3 carbon atoms or an allyl group, R3 represents an alkyl group with 1 or 2 carbon atoms substituted by a tetrahydrofuranyl, tetrahydropyranyl or cycloalkyl group, in which the cycloalkyl part may contain 3 to 7 carbon atoms, an alkenyl group with 3 to 5 carbon atoms or an alkynyl group with 3 or 4 carbon atoms, and W represents methyl, hydroxymethyl, formyl, carboxy or alkoxycarbonyl group, whilst the alkoxy part may contain from 1 to 4 carbon atoms and may be substituted by a phenyl group, and the enantiomers and salts thereof.
Patent FI-871490-A0 (FI)
Inventor: RIIKONEN PIRKKO LEENA ANNELI
IPC: A23K1/18
Filed: 1987-04-06
Abstract: The invention relates to a procedure for treating feed raw material which contains natural material. To the feed raw material is added enzyme preparation about 0.001-1 % by weight, the raw material is subjected to combined hydrothermal and enzymatic treatment at a temperature below 100  DEG C, dried to a moisture content about 5 - 30 % by weight so that the treated feed raw material can be blended into feed at a concentration about 5 - 95 %. The invention further relates to a hydrothermally and enzymatically treated feed raw material and a feed containing said treated natural material.
Patent FI-873802-A0 (FI)
Inventor: BUZAS ANDRE
IPC: C07D211/34
Filed: 1987-09-02
Abstract: Derivatives corresponding to either of the formulae which follow: 
<IMAGE>
 in which:
 - R1, R2, R3 and R4, which are identical or different, denote a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an aryloxy group or the trifluoromethyl group,
 - R denotes hydrogen, a cation, an alkyl group, an aryl group or an arylalkyl group,
 - n is equal to 0 or 1, and their pharmaceutically acceptable salts. 
<??>Application: treatment of spasmodic states and of allergies.
Patent FI-874251-A0 (FI)
Inventor: SCHUSTER BERND
IPC: H04J3/06
Filed: 1987-09-28
Abstract: A frame start word derived by superframe formation is found by testing for the presence of a correct binary value combination each bit position in a time window having the length of as many bits as framing bits are spaced apart, with the inclusion of so many overframes that a decision can be reached on the possibility of a relationsip to the frame start word. If this is to be excluded the corresponding bit position is flagged and thereafter no longer taken into consideration. Otherwise, the next binary value of the corresponding bit position is inferred from the binary value present. The procedure is continued, always including the same number of overframes until only one unflagged bit position remains.
Patent FI-884749-A0 (FI)
Inventor: OURIEL KENNETH
IPC: A61M1/36
Filed: 1988-10-14
Abstract: An autotransfuser (10) that includes, in a single receptacle (15), a pair of chambers (20, 30) separated by a common wall (16). Each receptacle can alternately perform, a blood infusion or blood collection function. Each chamber includes at least three inlets/outlets, a blood inlet (24, 34), a blood outlet (25, 35) and an air inlet means (22, 32). In some embodiments of the invention the air inlet means serves alternately to couple either an air or a pressure source on the one hand or a vacuum source on the other hand to the corresponding chamber. In other embodiments of the invention, the air inlet means comprises a vacuum inlet and a separate air or pressure inlet. A disk like device (40) or valve manifold is arranged for rotatable movement adjacent the inlets/outlets. The disk like device includes four channels, one for each of air or pressure (47), vacuum (46), blood collection (48) and blood infusion (49). Each channel includes a port for coupling to external tubing and at least one channel end. The channel ends are located in the disk like device so that by rotating the disk like device to two distinct positions, one or the other of the functions can be performed by each chamber. A blood valve is also disclosed which has a float element (104) having a specific gravity which allows it to float in a pool of human blood and a significant closure force in excess of about ten to fifteen grams.
Patent FI-900156-A0 (FI)
Inventor: SCHNEIDER ALFRED
IPC: E05D15/52
Filed: 1990-01-11
Abstract: There is described a window or door 21 with a wing 23 which is mounted on a fixed frame 22 by means of articulated fittings 26, 27 at or in the vicinity of a vertical limiting edge, the window or door being characterised, for relieving the articulated fittings 26, 27 of the vertical component of the weight or load of the wing 23, by a tension member 42 which, on the one hand, engages on the wing 23 in the region of the articulated fittings 26, 27 and, on the other hand, is anchored to the fixed frame 22 counter to the weight or load of the wing 23. 
<IMAGE>
Patent FI-900942-A0 (FI)
Inventor: FISCHER ARTUR
IPC: B23B47/18
Filed: 1990-02-23
Abstract: 2.1. To produce drilled holes to a defined depth, drills can be used which have a depth stop on the shank. 
<??>2.2. To avoid damage to the wall surface when the depth stop bears against it, a depth stop with an elastic damping element is proposed. 
<IMAGE>
Patent FI-901426-A0 (FI)
Inventor: NAVASCUES LUC ETIENNE ANDR
IPC: C05G3/30
Filed: 1990-03-21
Abstract: Anticaking compositions for fertilisers, of improved efficiency, assaying at 1 to 30 % of fatty amines in which the length of the aliphatic chains is distributed around 17.5 carbon atoms with a coefficient of variation which is characteristically greater than or equal to 2. High-performance anticaking agents are easily produced according to the conventional types of coating agents, fluxes or amine fillers, by being formulated with the aid of mixtures of industrial amines originating from natural fatty acids, deliberately combined to conform to this characteristic, or with the aid of synthetic fatty acids originating from the oxidation of normal paraffins.
Patent FI-906369-A0 (FI)
Inventor: LEE GUO-SHUH JOHN
IPC: C07C15/073
Filed: 1990-12-21
Abstract: Alkylated benzenes such as ethylbenzene and cumene are produced by alkylation and/or transalkylation in the presence of an acidic mordenite zeolite catalyst having a silica/alumina molar ratio of at least 30:1 and a crystalline structure which is determined by X-ray diffraction to have a Symmetry Index of at least 1 and an inert silica binder.
Patent FI-906438-A0 (FI)
Inventor: FLYNN GARY ALAN
IPC: A61K31/56
Filed: 1990-12-28
Abstract: The present invention relates to novel A-nor-steroid-3-carboxylic acid derivatives and to their use as inhibitors of mammalian 5 alpha -reductase.
Patent FI-915020-A0 (FI)
Inventor: LILJA JAN EVERT
IPC: G01N33/48
Filed: 1991-10-24
Abstract: PCT No. PCT/SE90/00272 Sec. 371 Date Oct. 16, 1991 Sec. 102(e) Date Oct. 16, 1991 PCT Filed Apr. 24, 1990 PCT Pub. No. WO90/12889 PCT Pub. Date Nov. 1, 1990.A method, a reagent composition and the use thereof for quantitative determination of total glucose in undiluted whole blood are described. A sample of undiluted whole blood is contacted with a reagent composition which is in dry form and comprises: glucose dehydrogenase (GDH); one or more substances from the group consisting of diaphorase, phenazine methosulphate, phenazine ethosulphate, phenazine phenosulphate and Meldola blue; one or more substances from the group consisting of NAD, NADP, thio-NAD, thio-NADP, nicotinamide-purine dinucleotide, nicotinamide-methylpurine dinucleotide, nicotinamide-2-chloro-methylpurine dinucleotide; one or more hemolysing substances from the group consisting of phospholipase, hemolysing saponins, and compounds of hydrophilic mono-, di- or tri-saccharides and aliphatic hydrocarbons having 10-16 carbon atoms; a redox indicator dye; and optionally mutarotase. A color change brought about by the reaction of the reagent with glucose in the undiluted whole blood is measured by transmission spectrophotometry.
Patent FI-920097-A0 (FI)
Inventor: HOLBEK JOHN
IPC: E04D5/02
Filed: 1992-01-09
Abstract: PCT No. PCT/DK90/00179 Sec. 371 Date Jan. 7, 1992 Sec. 102(e) Date Jan. 7, 1992 PCT Filed Jul. 10, 1990 PCT Pub. No. WO91/00945 PCT Pub. Date Jan. 24, 1991.A bituminous sheet or web coating material (1) is on the one side provided with a heat activatable adhesive layer (3) optionally covered by a plastic film (5), wherein the adhesive layer is provided with a pattern of close grooves (4) with intermediate unbroken ridges, and a process for forming a coating on a support is performed by heating such coating material (1) to decomposition of said plastic film (5) and activation of the adhesive layer (3), the activated adhesive layer (3) being pressed against the support, e.g. a roof.
Patent FI-923516-A0 (FI)
Inventor: KINZLER GERNOT
IPC: D21F1/02
Filed: 1992-08-04
Abstract: PCT No. PCT/EP92/00208 Sec. 371 Date Sep. 8, 1992 Sec. 102(e) Date Sep. 8, 1992 PCT Filed Jan. 31, 1992 PCT Pub. No. WO92/13995 PCT Pub. Date Aug. 20, 1992.A headbox includes a nozzle type stock channel with an outlet gap. The nozzle type stock channel is defined by two flow guide walls. Arranged on the discharge end of the upper flow guide wall is a movable aperture to which attach numerous adjustment spindles which are arranged distributed across the machine width. Each adjustment spindle has on its end away from the aperture a spindle drive. Provided on the upper end of each spindle is a measuring device serving the determination of the local position of the aperture. The measuring device has a measuring housing and a measuring element movable in it. The measuring element is connected positively with the aperture, independently of the spindle, by way of a measuring rod. The measuring housing is positively connected with the area of the flow guide wall on the near side of the aperture, by way of an oblong tubular measuring reference.
Patent FI-932283-A0 (FI)
Inventor: KLEBL WOLFRAM
IPC: B23K9/095
Filed: 1993-05-19
Abstract: In order to control the welding current as a function of the welding speed in the case of DC arc welding devices for continuous longitudinal-seam welding to the tube of formed metal strips, a voltage value (11), which is dependent on the welding speed, is added to an adjustable fixed voltage value (13). The sum of the speed-dependent voltage value (11) and the adjustable fixed-voltage value (15) additionally has a pulsed DC voltage value (28) superimposed on it. <IMAGE>
Patent FI-934934-A0 (FI)
Inventor: COMOGLIO PAOLO
IPC: C12N5/078
Filed: 1993-11-08
Abstract: A protein, which is useful as an antagonist of hepatocyte growth factor, is composed of two disulphide-linked chains of 50 kDa and 75 or 85 kDa respectively, the 50 kDa chain being the  alpha -chain of the tyrosine kinase encoded by the MET protooncogene and the 75 or 85 kDa chain being a C-terminal truncated form of the  beta -chain of the said tyrosine kinase.
Patent FI-943141-A0 (FI)
Inventor: HEAFIELD JOANNE
IPC: A61P25/04
Filed: 1994-06-30
Abstract: In order to provide a sustained release pharmaceutical formulation containing morphine which is suitable for administration on a once daily basis, in a first aspect, an orally administrable sustained release dosage unit form contains morphine, or a pharmaceutically acceptable salt thereof, as active ingredient, which formulation gives a peak plasma level at 1.0 to 6 hours after administration. In a second aspect, the formulation contains an effective amount of morphine or a pharmaceutically acceptable salt thereof, characterised by a W50 for the M-6-G metabolite or for morphine of between 4 and 12 hours. In a third aspect, the pharmaceutical dosage unit form is obtainable by compressing multiparticulates comprising a pharmaceutically active substance in a matrix of hydrophobic fusible material having a melting point of from 35 to 150 DEG C, the dosage form optionally containing conventional tabletting excipients. In a further aspect of the invention, sustained release multiparticulates containing morphine or a pharmaceutically acceptable salt thereof are produced by mechanically working in a high-speed mixer a mixture of particulate morphine or a pharmaceutically acceptable salt thereof and a particulate, hydrophobic fusible carrier or diluent having a melting point from 35 to 150 DEG C and optionally a release control component comprising a water soluble fusible material or a particulate soluble or insoluble organic or inorganic material at a speed and energy input which allows the carrier or diluent to melt or soften whereby it agglomerates, and breaking down the agglomerates to give controlled release particles.
Patent FI-945957-A0 (FI)
Inventor: STEINER GERD
IPC: A61P25/00
Filed: 1994-12-19
Abstract: PCT No. PCT/EP93/01438 Sec. 371 Date Dec. 16, 1994 Sec. 102(e) Date Dec. 16, 1994 PCT Filed Jun. 8, 1993 PCT Pub. No. WO94/00458 PCT Pub. Date Jan. 6, 1994.Abstract of the Disclosure: Compounds of the formula I    <IMAGE>  I  where R1, R2, n , R3, A, X, Y and Z have the meanings stated in the description, and the preparation thereof are described. The novel compounds are suitable for controlling diseases , i.e., as neuroleptics, antidepressants, sedatives, hypnotics, CNS protectives or muscle relaxants.
Patent FI-952525-A0 (FI)
Inventor: SJOEBERG STAFFAN
IPC: D21F1/32
Filed: 1995-05-24
Abstract: PCT No. PCT/SE93/01012 Sec. 371 Date May 17, 1995 Sec. 102(e) Date May 17, 1995 PCT Filed Nov. 24, 1993 PCT Pub. No. WO94/12349 PCT Pub. Date Jun. 9, 1994Cleaning apparatus, and a method of utilization of the apparatus, cleans an object with a moving surface, such as a roll. The cleaning apparatus includes a nozzle head with a suction nozzle and a jet nozzle for emitting a liquid jet towards the roll. A sub-pressure is maintained in a chamber of the suction nozzle in order to evacuate liquid and released impurities with the aid of air flowing through a gap between the roll and the orifice edge. The jet nozzle is spaced from the inside of the suction nozzle and at the center of the suction nozzle to form a circumferential passage, the passage communicating with an evacuation pipe. The nozzle head also includes a structure to supply compressed air into the chamber through the gap in order to encounter and carry with it toward the passage liquid and impurities, cooperating with the suction effect maintained in the chamber and the evacuation pipe. The compressed air also has the advantage of drying the roll treated with liquid.
Patent FI-955287-A0 (FI)
Inventor: BURNS DENNIS L
IPC: C08J9/08
Filed: 1995-11-03
Abstract: A molded closure for a liquid container comprising a thermoplastic elastomer and a blowing agent. The molded closure is particularly suitable for use as a synthetic wine cork in a wine bottle. The molded closure does not permit passage of oxygen into the container, does not absorb oxygen from the contents of the container, can be removed from the container using a corkscrew without significant expansion, crumbling or disintegration, does not significantly taint a liquid in the container, permits the container to be placed horizonzally immediately after insertion of the molded closure, and can permanently retain printed matter on its surface. <IMAGE>
Patent FI-963042-A0 (FI)
Inventor: MELOT DENIS
IPC: C08J5/18
Filed: 1996-08-01
Abstract: PCT No. PCT/FR95/01586 Sec. 371 Date Oct. 15, 1996 Sec. 102(e) Date Oct. 15, 1996 PCT Filed Dec. 1, 1995 PCT Pub. No. WO96/17003 PCT Pub. Date Jun. 6, 1996The invention relates to films based on PA-6 or PA-6,6 and on a copolymer containing polyamide (6 or 6,6) blocks and ploytetramethylene glycol blocks. They have greater impact strengths than PA-6 or PA-6, 6 film.
Patent FI-964656-A0 (FI)
Inventor: BALAI MARIA
IPC: C01B33/00
Filed: 1996-11-21
Abstract: Production of catalysts or catalyst additives comprises kneading and/or grinding, spray drying and heat treating a catalytically active component, preferably H-ZSM-5 zeolite, and aluminium hydroxide and/or aluminium hydroxy compound(s) and/or other binders and optionally kaolin(ite)- and even slurry containing liquefiers. The novelty is that instead of using kaolin(ite) as filler, silicic acid modifications of formula H4+y-zÄ(SiO4/2)x-y(AlO4/2)y(SiO3/2O)4-z (AlO3/2)zÜ (I) (where y<1; z<1; and x=0, 4, 10 or 16-18) are partially used.
Patent FI-970738-A0 (FI)
Inventor: LUTHI OSCAR
IPC: D21C9/18
Filed: 1997-02-21
Abstract: A drum having a longitudinal axis, and an outer periphery, has a multiplicity of longitudinal, drainage grooves formed therein, and a cylindrical sheath encloses the drum, the sheath having a multiplicity of holes formed therein. The drum is imperforate. A pair of the drums is employed in a twin-roll press as press rolls, and one thereof is used in a single roll press with a compaction baffle. In one embodiment, the press roll has its grooves formed in a herringbone pattern, the same pointed in the direction of rotation, to enhance drainage. In another embodiment, the longitudinal drainage grooves have increasing depth, toward a mid-length of the press roll where they open into inner-drum drainage conduits which discharge the filtrate adjacent the rotary axis of the press roll.
Patent FI-972198-A0 (FI)
Inventor: BECKETT RAYMOND PAUL
IPC: A61K31/16
Filed: 1997-05-23
Abstract: PCT No. PCT/GB95/02770 Sec. 371 Date May 21, 1997 Sec. 102(e) Date May 21, 1997 PCT Filed Nov. 27, 1995 PCT Pub. No. WO96/16931 PCT Pub. Date Jun. 6, 1996Compounds of general formula (I), principally characterized in that R4 is a polyether group, are water soluble matrix metalloproteinase inhibitors.    <IMAGE>  (I)
Patent IL-61382-A0 (IL)
Title: Azepinoindoles, their production and pharmalceutical compositions containing them
IPC: A61K31/55
Filed: 1980-10-31
Abstract: Azepinoindoles of formula 
<CHEM>
 wherein
 R1 and R2 are hydrogen, halogen, aklyl, alkoxy, alkylthio, hydroxy, or trifluoromethyl, R3 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkinyl or a group of formula 
<CHEM>
 wherein
 m is 1, 2 or 3,
 R4 is halogen, alkyl, alkoxy, or trifluoromethyl, and alkyl, alkoxy, or trifluoromethyl, and
 X is a bond, -CHOH- or -CO-,
 or a group of formula
 -(CH2-CH2-O)nH
 wherein
 n is 2 or 3, and
 R5 is hydrogen or alkyl, are useful neuroleptic, antidepressant and anti-allergic agents.
Patent IL-71297-A0 (IL)
Title: Electrolytic cell
Filed: 1984-03-20
Abstract: An electrolytic cell of the filter press type comprising a plurality of anodes, cathodes and gaskets, and ion-exchange membranes positioned between each adjacent anode and cathode to form in the cell a plurality of anode compartments and cathode compartments, the cell having two inlet headers from which electrolyte may be charged to the anode compartments of the cell and from which liquors may be charged to the cathode compartments of the cell, and two outlet headers from which products of electrolysis may be removed from the anode compartments and cathode compartments of the cell, the cell being provided with a common chamber in communication with each of the anode compartments and/or a common chamber in communication with each of the cathode compartments, said chamber(s) being provided with means for recirculating liquorstothe anode compartments and/orto the cathode compartments, and said chamber(s) being in communication with the outlet headers from the anode compartments and/or the outlet headers from the cathode compartments.
Patent IL-81421-A0 (IL)
Title: 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2h,4h)-diones,their preparation and anti-protozoal compositions containing them
IPC: A61P33/02
Filed: 1987-01-29
Abstract: Novel 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-­diones of formula wherein Ar is thienyl, halo substituted thienyl, naphthalenyl or a radical of formula the pharmaceutically acceptable acid addition salts and possible stereo­chemically isomeric forms thereof, which compounds are anti-protozoal agents; pharmaceutical compositions containing such compounds as an active ingredient; processes for preparing said compounds and pharmaceutical compositions; novel anti-protozoally active compounds used in the said processes.
Patent IL-94349-A0 (IL)
Title: Proteinase inhibitors
IPC: A61P17/00
Filed: 1990-05-10
Abstract: The invention comprises peptide variants based on the domains with inhibitory activity of human bicunin (i.e. the component with inhibitory activity of inter- alpha -trypsin inhibitor, or the acid-stable serum trypsin inhibitor, or the urinary trypsin inhibitor), methods for the preparation of these peptide variants with the aid of genetic engineering methods with microorganisms (bacteria, lower eukaryotes), and pharmaceutical compositions containing these peptide variants. The peptide variants are characterised by their ability to inhibit serine proteases, e.g. pancreatic and granulocytic elastase, cathepsin G or plasma kallikrein.