baber/WOPTO huggingface dataset:
Patent DE-69129192-T2 (DE)
Inventor: ERLICH HENRY
IPC: C12Q1/68
Filed: 1991-12-06
Granted: 1998-10-22
Abstract: Primers for amplification of specific nucleic acid sequences of the second exon of HLA DRbeta genes and probes for identifying polymorphic sequences contained in the amplified DNA can be used in processes for typing homozygous or heterozygous samples from a variety of sources and for detecting allelic variants not distinguishable by serological methods. This HLA DRbeta DNA typing system can be used in a dotblot format that is simple and rapid to perform, produces detectable signals in minutes, and can be used for tissue typing, determining individual identity, and identifying disease susceptible individuals.
Patent DE-69130182-T2 (DE)
Inventor: VERBRUGGEN ALFONS C O OCTROOIB
IPC: A61K51/04
Filed: 1991-04-10
Granted: 1999-01-28
Abstract: PCT No. PCT/US91/02450 Sec. 371 Date Aug. 21, 1992 Sec. 102(e) Date Aug. 21, 1992 PCT Filed Apr. 10, 1991.The invention relates to a method of preparing a radiolabelled technetium complex by bringing Tc-99m in the form of a pertechnetate solution in a complex-forming reaction with a compound of the general formula   <IMAGE> (I) wherein R1-R12 each independently represents a hydrogen atom, a C1-C4 alkyl group, a carboxy group, or a carboxy(C1-C4)alkyl group; or wherein R1+R2, R3+R4, R5+R6, R7+R8, R9+R10 and R11+R12 each independently represent an oxo or imino function; and wherein furthermore: R13 is a hydrogen atom, a C1-C4 alkyl group or a carboxy(C1-C4)alkyl group; R14 is a hydrogen atom or an amino group; n is 0, 1 or 2; A represents an amino group or a mercapto group; and B represents a mercapto group, or a group of the general formula NH-Z-CO-NH-mZ-COOH, wherein: Z is an optionally substituted C1-C4 alkylene, cycloalkylene or alkylidene group, and m is an integer from 0 to 20; with the provisos: (i) that at least one substituent selected from the group consisting of R1-R13 and B is or comprise a carboxy group; and (ii) that R3+R4 or R7+R8 represents an oxo function or both R3+R4 and R7+R8 or both R5+R6 and R7+R8 represent oxo functions, if A is an amino group and B is a group of the formula NH-Z-CO-NH-mZ-COOH;  by performing said reaction in the presence of Sn(II) as a reducing agent, in the absence of a transfer agent, in an at least substantially aqueous solvent system having a pH of at least 10, and at ambient temperature. The invention further relates to a kit for performing said method.
Patent DE-69130982-T2 (DE)
Inventor: NOSCO DENNIS
IPC: A61K49/00
Filed: 1991-05-03
Granted: 1999-08-19
Abstract: The present invention relates to novel technetium-99m complexes and to methods of preparaing the complexes. The present invention further relates to radiopharmaceutical compositions comprising the complexes, to the use of the compositions for examining the renal function, and to a kit for preparing such compositions.
Patent DE-69133447-T2 (DE)
Inventor: HYPPAENEN TIMO
IPC: B01J8/14
Filed: 1991-10-15
Granted: 2006-02-09
Abstract: The invention relates to a circulating fluidized bed reactor comprising a centrifugal separator and a method for separating particles from gases. The centrifugal separator (12) is a vortex chamber composed of cooling planar plates or panels (32, 34, 36) (i.e. they are distinctly non-cylindrical), having at least one gas inlet (40), at least one gas outlet (52) and at least one outlet (46) for the separated particles. The cross section of the side walls (32, 34, 36) of the vortex chamber forms a distinctly non-circular gas space (31) (e.g. a polygonal cross section), have a circularity of greater than 1, e.g. > 1.1, and preferably > 1.15. One or more vertical, parallel gas vortices may be created in the vortex chamber, the gas introduced into vertical narrow slots. The outlets (46) for separated particles are not one the same symmetrical axes as the outlets for purified gas (52). Two adjacent vortices may be provided in a common rectangular chamber. The separator (12) is preferably in conjunction with a circulating fluidized bed reactor (10).
Patent DE-69207745-T2 (DE)
Inventor: JAMET DANIEL
IPC: H04Q1/14
Filed: 1992-12-22
Granted: 1996-05-30
Abstract: Two identical parts (1, 1') assembled together constitute an optical cable guide rack fixed to the bottom of a chassis (9) fitted with circuit boards (10). Optical straps (13, 13') are guided between supporting members (4) and guide members (4'). Each optical target (14) can be easily placed on standby for connection with its end connecter portion (15) resting between two supporting members (4). It is thus possible to avoid tangling the optical straps (13, 13') and to substitute, with no risk of confusion, any one of the cables (17), connected to the front face of any one of the boards (10), with the target (14) placed on standby. <IMAGE>
Patent DE-69209679-T2 (DE)
Inventor: VIDAL RAMON MERCE
IPC: C07D403/06
Filed: 1992-01-22
Granted: 1996-10-10
Abstract: Heterocyclic compounds, characterised in that they correspond to the general formula I 
<IMAGE>
 in which 
 
  Ar represents a nitrogenous or non-nitrogenous aromatic radical, chosen from the variously substituted aryls, 2-pyrimidine, 2-(N-methyl)imidazole and 3-(1,2-benzisotriazole) 
  n can have the values 1 to 6 
  Z1 represents a nitrogen atom or a group C-R1 
  Z2 represents a nitrogen atom or a group C-R2 
  Z4 represents a nitrogen atom or a group C-R4 
  Z5 represents a nitrogen atom or a carbon atom 
  Z6 represents a substituted or unsubstituted aza group or methylene group, 
  provided that when Z5 represents a nitrogen atom, Z6 is a substituted or unsubstituted methylene group, and that when Z5 is a carbon atom, Z6 is a substituted or unsubstituted aza group, 
  and R1, R2, R3 and R4, which are identical or different, also being able to form a part of another aromatic or non aromatic ring, represent a hydrogen atom, a halogen, a lower alkyl radical, a hydroxyl radical, a carboxyl radical, a carboxamido radical, an alkyloxycarbonyl radical or an aryl or substituted aryl radical, 
  and when Ar is 2-pyrimidine and Z6 is a substituted or unsubstituted methylene group, the assembly Z1, Z2, Z4 and Z5 forms an aromatic heterocycle, chosen from the group comprising the trisubstituted imidazole, the substituted or unsubstituted benzimidazole and the substituted or unsubstituted imidazopyridine radical, 
 and their addition salts with pharmaceutically acceptable acids, except for the compounds for which Ar is a substituted or unsubstituted phenyl, Z5 and Z2 each represent a nitrogen atom, Z1 represents a group C-R1 and Z4 a group C-R4, and R3-R4 form a part of another aromatic ring.
Patent DE-69213892-T2 (DE)
Inventor: FUJITA TAKASHI
IPC: C07C217/22
Filed: 1992-11-20
Granted: 1997-04-17
Abstract: Compounds of formula (I) : <CHEM> (in which: R<0> is hydrogen, methyl or hydroxymethyl; R<1> is substituted alkyl; R<2> and R<3> are each hydrogen, halogen, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkyl, nitro, haloalkyl, or substituted alkyl; X is oxygen atom or a sulphur; and Ar optionally substituted phenyl or naphthyl); and pharmaceutically acceptable salts thereof have a variety of valuable pharmaceutical activities, including anti-diabetic and anti-obesity activities; in addition, they are capable of treating or preventing hyperlipemia and hyperglycemia and, by inhibiting the action of aldose reductase, they can also be effective in the treatment and prevention of complications of diabetes.
Patent DE-69224093-T2 (DE)
Inventor: FEIGELSON GREGG BRIAN
IPC: C07D487/04
Filed: 1992-02-21
Granted: 1998-05-07
Abstract: New 4-substituted azetidinones having the formulae I and II: <CHEM> with R<1>, R<2>, R<3>, R<4>, R<5> and X defined hereafter, which are intermediates for the preparation of carbapenem and carbacephem antibacterials and processes for producing such antibacterials through the utilization of an acid mediated ring closure reaction.
Patent DE-69233322-T2 (DE)
Inventor: FOELDI PETER
IPC: G02B6/42
Filed: 1992-05-15
Granted: 2005-02-24
Abstract: A device for optically connecting an optical element, for example an end portion of an optical fibre (2), with a spherical lens (4), comprises a retainer (6) and a connector element (14). The retainer (6) fixes the optical element in a predeterment position in relation to an outer reference surface (8) of the retainer. The connector element (14) has at least one surface (18) for determining the position of the spherical lens (4) and at least one surface (16) for determining the position of the retainer (6) in relation to the spherical lens (4) and thereby for defining the relative position between the optical element (2) and the spherical lens (4). The surface (18) for determining the position of the spherical lens (4) is constituted by a conical surface (18) tapering in the direction of the optical element (2).
Patent DE-69305751-T2 (DE)
Inventor: MEYER THOMAS
IPC: C08L83/08
Filed: 1993-12-14
Granted: 1997-03-06
Abstract: PCT No. PCT/US93/11906 Sec. 371 Date Jun. 6, 1995 Sec. 102(e) Date Jun. 6, 1995 PCT Filed Dec. 14, 1993 PCT Pub. No. WO94/13258 PCT Pub. Date Jun. 23, 1994Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising a secondary polyamine, and dispensing means for simultaneously or sequentially providing desired amounts of dihydroxyacetone and polyamine.
Patent DE-69306958-T2 (DE)
Inventor: BUSBY ANDREW DAVID
IPC: B22C5/00
Filed: 1993-08-23
Granted: 1997-05-07
Abstract: PCT No. PCT/GB93/01792 Sec. 371 Date May 12, 1995 Sec. 102(e) Date May 12, 1995 PCT Filed Aug. 23, 1993 PCT Pub. No. WO94/05448 PCT Pub. Date Mar. 17, 1994This invention relates to a process for reclaiming ester-cured phenolic resin bonded sand. The process comprises contacting attrition reclaimed sand with a compound which converts potassium compounds to a form having a melting point of least 550 DEG  C., and then thermally treating the sand at a temperature below that which the resulting potassium compound fuses.
Patent DE-69315817-T2 (DE)
Inventor: DIAS DE MAGALHAES QUEIROZ JOAO
IPC: F16F3/12
Filed: 1993-09-29
Granted: 1998-07-09
Abstract: PCT No. PCT/PT93/00005 Sec. 371 Date Aug. 1, 1994 Sec. 102(e) Date Aug. 1, 1994 PCT Filed Sep. 29, 1993 PCT Pub. No. WO94/07395 PCT Pub. Date Apr. 14, 1994An elastic framework for a mattress, chair, upholstery, etc. is disclosed which includes elastic springs made of opposing upper and lower elastic elements, each elastic element having a base portion and a plurality of flexible arms which extend from the base portion and are joined to the flexible arms of the opposing upper or lower element so as to form a closed flexible ring. These flexible rings are joined to top support elements and bottom support elements at the base portion of the upper and lower elastic elements, respectively, and the top support elements as well as the bottom supported elements are respectively interconnected so as to form a spring support.
Patent DE-69318169-T2 (DE)
Inventor: ENGELHOLM TORBJOERN
IPC: A23N15/06
Filed: 1993-09-02
Granted: 1998-09-03
Abstract: A roller and a machine provided with a roller for peeling or shaping potatoes and similar products, the roller (8) comprising a cylindrical body (14) having a grinding surface (13) for contacting with the product (17) to be treated. To simplify the manufacture of the roller and enable the treatment of soft products, the grinding surface of the roller body has axially extending grooves (15) which form several treatment teeth (16) mutually spaced in the peripheral direction of the grinding surface.
Patent DE-69321909-T2 (DE)
Inventor: HECTOR RICHARD F
IPC: A61K39/395
Filed: 1993-08-16
Granted: 1999-04-01
Abstract: Bacterial meningitis infection in a mammal is treated by intravenous infusion of therapeutically effective amounts of monoclonal antibodies which bind to tumor necrosis factor alpha. Treatment can be initiated up to five hours after bacterial challenge and is preferably in combination with an antibiotic selected from cephalosporins and aminoglycosides.
Patent DE-69322675-T2 (DE)
Inventor: BERLINER DAVID
IPC: A61K8/34
Filed: 1993-03-24
Granted: 1999-07-22
Abstract: The invention concerns novel, non-therapeutic fragrance compositions and other compositions containing an odorant and a naturally occurring human pheromone. The invention also concerns fragrance compositions containing mixtures of naturally occurring human pheromones. The human pheromones disclosed are steroids which desirably belong to two distinct chemical classes: 16-Androstenes and Estrenes.
Patent DE-69327092-T2 (DE)
Inventor: YANO SHINGO - -
IPC: A61K31/40
Filed: 1993-09-08
Granted: 2000-05-25
Abstract: An optically active form of a compound represented by the following formula (II) below is useful as an agent for treating hyperlipidemia which has an activity to inhibit the synthesis of fatty acids and an activity to inhibit the synthesis of cholesterol <CHEM> wherein R' is a hydrogen atom or a lower alkyl group such as an alkyl group having 1 to 6 carbon atoms, and a synthesis method for same is described.
Patent DE-69328341-T2 (DE)
Inventor: GUTTER BEZALEL
IPC: A61K39/395
Filed: 1993-12-01
Granted: 2000-12-14
Abstract: The invention relates to a vaccine for the prevention of Infectious Bursal Disease in poultry comprising an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92052301 (MB), an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92100106 (MB-2), or an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92102209 (MB-1). In addition, the invention relates to a method of preventing Infectious Bursal disease in poultry by administering to the birds an effective immunizing amount of the said vaccines. The invention relates to three novel virus strains deposited at the ECACC under No. V92052301 (MB), under No. V92100106 (MB-2) and under No. V92102209 (MB-1). Furthermore, the invention relates to a method of preparing live vaccines which protect poultry against Infectious Bursal Disease, containing an effective immunizing amount of a virus of the strain deposited at the ECACC under No. V92052301 (MB) and/or No. V92100106 (MB-2) and/or No. V92102209 (MB-1).
Patent DE-69331763-T2 (DE)
Inventor: TUBA ZOLTAN
IPC: A61P43/00
Filed: 1993-06-24
Granted: 2002-10-02
Abstract: The invention relates to a novel process for preparing 17 beta -substituted 4-azaandrostane derivatives of general formula (I) wherein R represents hydrogen or a C1-3alkyl group; R<1> represents a carboxamido group mono- or disubstituted by C1-8alkyl group(s); or a free carboxyl group; or a carboxyl group esterified with a C1-5 alcohol; and the - &cir& _- &cir& _- &cir& _- &cir& _ bond line represents a single or double bond; as well as their salts. The process comprises reacting a 17-halogeno-4-azaandrostene derivative of general formula (II) wherein R and the - &cir& _- &cir& _- &cir& _- &cir& _ bond line are as defined above, and X is chlorine, bromine or iodine, with a primary or secondary alkylamine or a C1-5 alcohol, in dimethylformamide or dimethylsulfoxide medium in the presence of a palladium(II) salt and phosphines or a palladium(II) complex and a tertiary amine base in carbon monoxide atmosphere at a temperature between 35  DEG C and 80  DEG C, then, if desired, transforming an obtained compound of general formula (I) to another compound of general formula (I) by hydrogenation, hydrolysis or salt forming reaction.
Patent DE-69332276-T2 (DE)
Inventor: SATO SYUJI
IPC: A61K47/48
Filed: 1993-04-09
Granted: 2003-01-09
Abstract: A liposome composition effective in administering a physiologically active substance to Peyer's glands. It has a high ability to migrate toward Peyer's glands and contains phosphatidylcholine, cholesterol and phosphatidylinositol as lipid components.
Patent DE-69332346-T2 (DE)
Inventor: CHRISTEL PASCAL
IPC: C08K3/24
Filed: 1993-04-02
Granted: 2003-12-24
Abstract: Material for bioresorbable bone prosthesis, containing particles of calcium carbonate originating, for example, from coral skeleton and dispersed within a polymeric matrix, the said particles having dimensions of less than 1 mm and representing from 40 to 70 % of the total weight, and the said polymer being a bioresorbable polymer.
Patent DE-69414143-T2 (DE)
Inventor: CAVALIE CHARLES
IPC: D01F6/60
Filed: 1994-01-21
Granted: 1999-04-08
Abstract: The present invention relates to pigmented filaments, fibres, monofilament yarns or multifilament yarns, based on polyamide, having improved stability with respect to degradation by ultraviolet radiation and atmospheric agents. They contain, in particular, from 15 to 100 ppm of copper with respect to the weight of polyamide, in the form of a copper compound, from 800 to 2000 ppm of halogen in the form of a metal halide, and from 40 to 200 ppm of manganese in the form of a manganese compound. They find their application in the form of textile surfaces, in particular flocked surfaces, nonwovens, carpets, for indoor and outdoor use, such as sports pitches, amusement areas, artificial lawns, etc.
Patent DE-69416117-T2 (DE)
Inventor: TUGHAN GARFIELD CECIL
IPC: C07D477/00
Filed: 1994-03-17
Granted: 1999-06-24
Abstract: A process for the preparation of antibacterial compound (I) or a salt thereof which comprises hydrogenolysis of the novel compound of formula (II) and if necessary or desired isolating the resultant carboxylic acid as a salt thereof.
Patent DE-69416386-T2 (DE)
Inventor: KOSUGI MASAYUKI
IPC: E21B47/08
Filed: 1994-11-29
Granted: 1999-08-26
Abstract: A method for measuring three-dimensional displacement of a mass comprises the steps of providing a measuring object placed on the end surface of the mass, for reflecting at least a fraction of three-dimensional displacement of the mass, arranging a displacement measuring equipment for free displacement relative to the mass and in opposition to the measuring object, and measuring three-dimensional relative displacement of the mass by detecting relative displacement of sad displacement indicative means relative to the displacement measuring equipment by the latter. The method is implemented by a three-dimensional displacement measuring system comprises a measuring object placed on the end surface of the mass, for reflecting at least a fraction of three-dimensional displacement of the mass, a displacement measuring equipment arranged for free displacement relative to the mass and in opposition to the measuring object, for measuring three-dimensional relative displacement of the mass by detecting relative displacement of sad displacement indicative means relative to the displacement measuring equipment by the latter. The method and system is suitable for measuring displacement of a rock across a crack.
Patent DE-69421008-T2 (DE)
Inventor: JOHNSON DAVID A
IPC: H01R12/72
Filed: 1994-06-22
Granted: 2000-06-08
Abstract: Apparatus for electrically interconnecting a lead of an integrated circuit device to a terminal spaced at a distance from the lead, such as on a printed circuit board. The apparatus is also useful for interconnecting two printed circuit boards. The apparatus includes a housing which has at least two flanges extending therefrom. The flanges are spaced a distance with an elastomeric element captured thereby and extending therebetween. A conductive contact is mounted on the elastomeric element and thus freely suspended for contact with terminals to be interconnected. A multiplicity of such contacts may be arranged in a suitable pattern for interconnecting specified integrated circuit devices with a printed circuit board. The contact shape can be generally disk-like to provide maximum wiping action and to facilitate airtight contact between the terminal and interconnect apparatus. <IMAGE>
Patent DE-69431517-T2 (DE)
Inventor: BRIEADDY EDWARD
IPC: C07D417/04
Filed: 1994-02-15
Granted: 2003-06-12
Abstract: PCT No. PCT/GB94/00314 Sec. 371 Date Aug. 15, 1995 Sec. 102(e) Date Aug. 15, 1995 PCT Filed Feb. 15, 1994 PCT Pub. No. WO94/18184 PCT Pub. Date Aug. 18, 1994The invention provides novel 1,4-benzothiazepine compounds substituted with hydroxy or a group containing hydroxy, compositions comprising such compounds and their use in the treatment or prophylaxis of treating clinical conditions in which inhibition of bile acid uptake is indicated, for example, hyperlipidemia and atherosclerosis.
Patent DE-69432052-T2 (DE)
Inventor: AVIV JONATHAN E
IPC: A61M13/00
Filed: 1994-04-15
Granted: 2004-03-18
Abstract: An apparatus and method to objectively measure sensory discrimination thresholds at a test site in the upper aero digestive tract of a patient. A time and pressure controlled puff of air is delivered to the input of a Y-shaped tube; one output branch of the Y-shaped tube delivers the puff of air to the patient and the other output branch delivers the puff of air to a pressure transducer, for measurement and display of the pressure.
Patent DE-69500637-T2 (DE)
Inventor: RIONDEL ALAIN
IPC: B01J21/06
Filed: 1995-04-07
Granted: 1998-02-12
Abstract: The prepn. of sec. butyl acrylate, by the reaction of acrylic acid, CH2=CH.COOH with 1-butene, 2-butene or their mixts., in the presence of a catalytic amt. of an acid catalyst comprising a solid super-acid based on zirconium. Also claimed is the catalyst prod. resulting from the reaction of zirconium hydroxide with ammonium sulphate.
Patent DE-69509508-T2 (DE)
Inventor: PETHOE LAJOS
IPC: A61J1/20
Filed: 1995-02-21
Granted: 1999-09-02
Abstract: The invention relates to an apparatus for mixing aseptically three or more liquid products (51, 53, 55) and includes at least two pointed connection devices (1, 21, 41) which are provided with through-passing flow passageways (3, 4, 24, 25, 43, 44) and are connected in series by means of a connecting line (61) and are intended to be inserted through penetrable closure means (58, 59, 60) of product containers (52, 54, 56). A first of these connection devices (1) functions to place the first container (52) in communication with the surroundings via a sterilizing filter (7), and connects the first container with the second container (54) through the connecting line (61), wherein the product containers are mutually connected together successively by means of respective subsequent connection devices down to the last product container (56) in line in which the final mixture of products, including the product (55), is collected. A subpressure prevails in the last container in line, this subpressure constituting the force by means of which the products are driven through the system. The invention also relates to a connection device (21) and to a system for aseptically mixing three or more liquid products, and also to a method of mixing the products. The invention is primarily intended for application when mixing the liquid components of a preparation for parenteral nutrient supply.
Patent DE-69511956-T2 (DE)
Inventor: ZUBER JEAN-MARC
IPC: F23G7/12
Filed: 1995-06-28
Granted: 2000-05-04
Abstract: The installation includes a store (1) for old tyres which may either be complete, or chopped up. A grap hook is mounted on a rail above the store in order move along over the store, and lift the tyre waste material. It is arranged to load predetermined quantities of tyre waste into a hopper (12). The hopper has an output extractor (20) which supplies the waste to a transporter and doser (29). This aims to provide a steady weight flow rate to the furnace, via a conveyor (31) and inlet (32). <IMAGE>
Patent DE-69527294-T2 (DE)
Inventor: DALUGE MARY
IPC: A61P31/14
Filed: 1995-08-25
Granted: 2003-02-13
Abstract: The present invention relates to the succinate salt of (1S,4R)-<u>cis</u>-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol or a solvate thereof, to pharmaceutical formulations containing such a compound or pharmaceutical formulations, and to its use in medical therapy or in methods of treatment or prophylaxis of a viral infection, specifically human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infection.