baber/WOPTO huggingface dataset:
Patent EP-3798321-A1 (EP)
Title: Distinguishing methylation levels in complex biological samples
Inventor: TOUNG JONATHAN
IPC: G16B40/00
Filed: 2016-12-15
Abstract: Provided herein is a method for distinguishing an aberrant methylation level for DNA from a first cell type, including steps of (a) providing a test data set that includes (i) methylation states for a plurality of sites from test genomic DNA from at least one test organism, and (ii) coverage at each of the sites for detection of the methylation states; (b) providing methylation states for the plurality of sites in reference genomic DNA from one or more reference individual organisms, (c) determining, for each of the sites, the methylation difference between the test genomic DNA and the reference genomic DNA, thereby providing a normalized methylation difference for each site; and (d) weighting the normalized methylation difference for each site by the coverage at each of the sites, thereby determining an aggregate coverage-weighted normalized methylation difference score. Also provided herein are sensitive methods for using genomic DNA methylation levels to distinguish cancer cells from normal cells and to classify different cancer types according to their tissues of origin.
Patent EP-3978412-A1 (EP)
Inventor: AITAMURTO JUHA-MATTI
IPC: B66B9/00
Filed: 2020-10-02
Abstract: An elevator safety system (110) comprising an elevator control unit (1000) configured to: monitor (610) an elevator shaft (13), receive (620) a position, a movement direction, and a speed of at least one elevator car (10) arranged into the elevator shaft (13), and determine dynamically (630) at least one authorized shaft section (21) based on the monitoring, and on the position, the movement direction, and the speed of at least one elevator car (10), and to provide (640) an authorization to the at least one elevator car (10) to move, such as by a linear motor, in or into the authorized shaft section (21) of the elevator shaft (13). The elevator safety system (110) further comprises at least one elevator car controller (30) configured to: provide the position, the movement direction, and the speed of the at least one elevator car to the elevator control unit (1000), and receive the authorization. The elevator control unit (1000) and the elevator car controller (30) are arranged to be in communication with each other.
Patent EP-3816636-A1 (EP)
Title: Methods for closed loop operation of capacitive accelerometers
Inventor: TOWNSEND KEVIN
IPC: G01P15/125
Filed: 2020-10-02
Abstract: A capacitive accelerometer comprising a pulse width modulation (PWM) signal generator, a closed loop circuit (10), and first and second fixed capacitive electrodes (1, 2) arranged symmetrically either side of a proof mass along a sensing axis of the proof mass. The proof mass is moveable along the sensing axis in response to an applied acceleration, and the fixed capacitive electrodes (1, 2) are arranged such that a gap is defined between each of electrodes (1, 2) and the proof mass under zero applied acceleration. The PWM signal generator is arranged to apply first and second drive signals V 1  and V 2  to the first and second fixed capacitive electrodes (1, 2) respectively. The first and second drive signals each have a periodic waveform varying in amplitude between zero and a maximum value V ref . The closed loop circuit (10) is arranged to detect a signal resulting from the displacement of the proof mass and to control the PWM signal generator to apply the first and second drive signals at a constant frequency f mod  with a variable mark/space ratio so as to provide a net electrostatic restoring force on the proof mass for balancing the inertial force of the applied acceleration and maintaining the proof mass at a null position. A voltage offset V ref /2 is also applied to the proof mass, and the first and second drive signals have a waveform that varies so that when either one of the first and second drive signals is at V ref  or zero the other drive voltage is at Vref/2.
Patent EP-3812540-A1 (EP)
Inventor: SUHOLUTSKAJA ELENA
IPC: E05B83/16
Filed: 2020-10-19
Abstract: Gegenstand der Erfindung ist ein Kraftfahrzeug-Schloss, insbesondere Kraftfahrzeug-Türschloss und vorzugsweise ein Haubenschloss, welches mit einem Gesperre (2, 3) aus im Wesentlichen Drehfalle (2) und Sperrklinke (3) ausgerüstet ist. Außerdem ist eine Aufstelleinrichtung (6, 7, 8) für einen Schließbolzen (4) oder ein anderes Anschlagteil an einer Haube (5) vorgesehen. Die Aufstellreinrichtung (6, 7, 8) ist mit einem Stellmittel (8) zur Realisierung einer Abhebeposition der Haube (5) ausgerüstet. Erfindungsgemäß wird das Stellmittel (8) von einem Gesperrebauteil (2, 3) zur Wechselwirkung mit der Haube (5) beaufschlagt.
Patent EP-3984385-A1 (EP)
Inventor: BOUCHUIGUIR LAYTH SLIMAN
IPC: A24F40/53
Filed: 2020-10-19
Abstract: The present invention relates to a vaporizer configured to be connected to a consumable container for vaporizing a consumable contained in the consumable container, a vaporizer connecting surface of the vaporizer being connected to a consumable container connecting surface of the consumable container when the vaporizer is connected to the consumable container, wherein the vaporizer comprises one or more detecting units comprising a resilient member on the vaporizer connecting surface, on which the resilient member can take a projected or retracted position, configured to detect one or more aspects of the shape of the consumable container connecting surface encoding information about the consumable container by detecting whether or not or to which extent the resilient member is in a projected or retracted position when the vaporizer is connected to the consumable container.
Patent EP-3791941-A1 (EP)
Inventor: SHIGETA YASUSHI
IPC: A63F1/06
Filed: 2019-03-08
Abstract: Provided is a trading card in which a trading card package and content of the trading card package are linked and the content can be specified, and thus an illegal act can be found. A manufacturing method for a trading card package includes a step of grouping trading cards 4 on which rareness degree RM information is printed and a step of packaging the grouped trading cars 4. Trading card IDs 2 are imparted to the trading cards 4. In the grouping step, the trading card IDs 2 are registered in a database DB. A package ID 3 is imparted to a package 1. The package ID 3 is enclosed in the package 1 or provided on the package 1. The package ID 3 of the package 1 including the trading cards 4 and the trading card IDs 2 and the rareness degrees RM included in the package 1 are associated.
Patent EP-3816343-A1 (EP)
Title: Artificial leather and production method therefor
Inventor: HIRONAKA DAISUKE
IPC: D06N3/14
Filed: 2020-10-29
Abstract: [PROBLEM TO BE SOLVED]To provide an artificial leather which can be suitable used as the upholstery or inner material of seats for interior, automobiles, aircraft, and railway vehicles, as well as clothing products and which has both a suitable texture (stiffness) and crease recovery.[MEANS TO SOLVE THE PROBLEM]The artificial leather includes a fiber sheet and a polyurethane resin, wherein the fiber sheet includes at least a fiber layer (A) constituting a first outer surface of the artificial leather, a cross-sectional polyurethane resin area ratio in the thickness direction of the fiber layer (A) is 15% to 30%, and standard deviation of the cross-sectional polyurethane resin area ratio of the fiber layer (A) is 25% or less.
Patent EP-3865119-A1 (EP)
Inventor: CSAKY KARL
IPC: A61P27/02
Filed: 2014-05-01
Abstract: The present invention generally relates to local therapies for the eye and, more particularly, to shaped controlled-release ocular implant devices, including methods for making and using such devices, for delivery of therapeutic agents to the eye. A molded two-layer ocular implant comprises a therapeutic agent for treatment or prevention of a disorder of the eye. The implant comprises a polymer layer and a silicone adhesive layer with a therapeutic agent interspersed therein and joined to the polymer layer. This implant is for placement in the sub-Tenon's space of the eye and provides sustained release of the therapeutic agent during the treatment or prevention of the disorder of the eye.
Patent EP-3812012-A1 (EP)
Inventor: MARIAMPILLAI BRIAN
IPC: A62D1/00
Filed: 2015-11-26
Abstract: A composition comprising: 
     (a) 10 - 75 wt% of at least one thickening agent; 
     (b) 15 - 90 wt% of at least one liquid medium; and optionally 
     (c) at least one suspending agent, wherein the suspending agent is, optionally, a surfactant, emulsifier or both, 
     wherein the composition consists of >85%, by weight, food-grade components and wherein mixture of said composition with water or an aqueous solution forms a fire-suppressing, water-enhancing hydrogel. 
     A hydrogel, comprising: 
     0.1 - 30 wt% of said composition; and 
     70 - 99.9 wt% of water or an aqueous solution, 
     wherein the hydrogel is a water-enhancing, fire-suppressant, useful for fire-fighting, fire-suppression, and/or fire-prevention.
Patent EP-3825001-A1 (EP)
Inventor: FREER ERIK M
IPC: B01J27/232
Filed: 2015-09-16
Abstract: Catalysts, catalytic forms and formulations, and catalytic methods are provided. The catalysts and catalytic forms and formulations are useful in a variety of catalytic reactions, for example, the oxidative coupling of methane. Related methods for use and manufacture of the same are also disclosed.
Patent EP-3824925-A1 (EP)
Title: Drug delivery device
Inventor: CRONENBERG RICHARD A
IPC: A61M5/14
Filed: 2011-03-28
Abstract: The subject invention provides a drug delivery device for injecting medicament which includes: a tubular reservoir for accommodating a medicament; a stopper slidably disposed in the reservoir; a spring for moving the stopper from a first position to a second position in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle from a first state to a second state; and, an actuator. Activation of the actuator causes the spring to move the stopper from the first position and towards the second position, and the needle driver to displace the needle from the first state and towards the second state. The needle moves relative to, and separately from, the reservoir with the needle being displaced from the first state and towards the second state. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.
Patent EP-3910481-A1 (EP)
Inventor: KWOK ZION
IPC: G11C7/10
Filed: 2020-12-22
Abstract: Technologies for scrambling functions in a column-addressable memory architecture includes a device having a memory and a circuitry. The memory includes a matrix storing individually addressable bit data, and the matrix is formed by rows and columns. The circuitry is to receive a request to perform a write operation of one or more bit values to one of the columns. The circuitry is further to determine a scrambler state at each location of the column, the location corresponding to a respective row and column index. The scrambler state is indicative of a function used to determine a value at the respective column location. Each of the bit values is scrambled as a function of the scrambler state for the respective column location and written thereto.
Patent EP-3929741-A1 (EP)
Inventor: CHEN HUAMIN
IPC: G06F9/455
Filed: 2020-12-22
Abstract: Systems and methods for inter-cluster deployment of compute services using federated operator components are generally described. In some examples, a first request to deploy a compute service may be received by a federated operator component. In various examples, the federated operator component may send a second request to provision a first compute resource for the compute service to a first cluster of compute nodes. In various examples, the first cluster of compute nodes may be associated with a first hierarchical level of a computing network. In some examples, the federated operator component may send a third request to provision a second compute resource for the compute service to a second cluster of compute nodes. The second cluster of compute nodes may be associated with a second hierarchical level of the computing network that is different from the first hierarchical level.
Patent EP-3903677-A1 (EP)
Inventor: EDOUARD PAUL
IPC: A61B5/1455
Filed: 2020-04-30
Abstract: A non-invasive method to determine a current functional blood oxygen saturation level (SpO2) : 
a- acquiring, at a sampling frequency, a photoplethysmography light response for each wavelength of a plurality of at least three wavelengths (λ1, λ2, λ3), resulting respectively in a first, second and third raw data series, 
b- applying a low-pass filter to each of the first, second and third raw data series, resulting respectively in a first, second and third DC data series representing an unmodulated amplitude response 
c- determining respectively in a first, second and third AC data series representing an unmodulated amplitude response, 
d- applying a computation engine to the first, second and third AC and DC data series, and determining therefrom a user current blood oxygen saturation level.
Patent EP-4023269-A1 (EP)
Inventor: DESILLES JEAN-PHILIPPE MICKAEL
IPC: A61L31/08
Filed: 2020-12-29
Abstract: The present invention relates to improved clot retrieval devices, wherein at least the part of the device intended to be in contact with a clot is coated with at least one chromatin binding agent selected from the group consisting of digoxigenin, a digoxigenin derivative, distamycin and a distamycin derivative. The present invention also relates to a method of producing said improved clot retrieval device. The present invention also relates to a method of prevention and/or treatment of stroke in a subject, comprising removing at least one clot using the clot retrieval device coated with said least one chromatin binding agent.
Patent EP-3978487-A1 (EP)
Title: 2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-1-yl)-acetamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5
Inventor: BOSSER ARTAL RAMÓN
IPC: C07D413/14
Filed: 2020-09-30
Abstract: The present invention relates to novel 2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-1-yl)-acetamide derivatives as potent inhibitors of transforming growth factor-β receptor I, (also named activin receptor-like kinase 5) (TGFβRI)/ALK5. Other objectives of the present invention are to provide a procedure for preparing these compounds; pharmaceutical compositions comprising an effective amount of these compounds; the use of the compounds for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by inhibition of transforming growth factor-β receptor I (TGFβRI)/ALK5, such as respiratory diseases including idiopathic pulmonary fibrosis, asthma, COPD and lung cancer, and dermal and ocular fibrotic conditions.
Patent EP-4001261-A1 (EP)
Inventor: ALONSO SILVA IGNACIO
IPC: C07C231/14
Filed: 2020-11-23
Abstract: The present invention refers to a procedure to obtain iohexol from TAIPA in which the formation of acetyl-TAIPA occurs without the use of alcoholic solvents and its subsequent alkylation with (±)-1-chloro-2,3-propanediol (CPD) to obtain crude iohexol using low toxicity solvents and under reaction conditions which allow to minimize the formation of impurities, increase the overall yield and simplify operation.
Patent EP-3914735-A1 (EP)
Inventor: DE VILLIERS-ZUR HAUSEN ETHEL-MICHELE
IPC: C12Q1/70
Filed: 2020-01-24
Abstract: La présente invention concerne des séquences de nucléotides CMI (isolat issu du lait de vache) ainsi que des sondes et des amorces comprenant une partie desdites séquences de nucléotides et des anticorps contre des polypeptides codés par lesdites séquences de nucléotides. Ces composés sont utiles en tant que marqueurs précoces du futur développement d'un cancer, d'un diabète, d'une artériosclérose et de maladies du SNC (sclérose en plaques, maladies à prions, sclérose latérale amyotrophique, encéphalite spongiforme transmissible, maladie de Parkinson, maladie d'Alzheimer) et devraient servir de cibles pour le traitement et la prévention de ces maladies.
Patent EP-3911770-A1 (EP)
Inventor: GECCHELE FABIO
IPC: C14B17/00
Filed: 2020-01-14
Abstract: A hatch (1) for access to a rotating drum (2), particularly for machines for processing hides, fabrics, and the like, which includes at least one movable panel (10) slidingly supported in a frame (20) associated with the drum (2), defining at least one closed position, in which the panel (10) obstructs an opening (3) provided in a circumferential wall (4) of the drum, and at least one open position, in which the panel (10) clears the opening; the frame (20) includes a guiding means (21a, 21 b) which is slidingly engaged with the panel (10) to guide its circumferential sliding in the transition between the closed position and the open position.
Patent EP-3941894-A1 (EP)
Inventor: KELLER ANDREAS
IPC: C07C29/38
Filed: 2020-03-18
Abstract: The presently claimed invention relates to a process for the recovery of 3-methyl-3-buten- -ol from a stream comprising (Z)-3-methylpent-2-ene-1,5-diol, (E)-3-methylpent-2-ene-,5-dioland 3-methylenepentane-1,5-diolby treating the stream with isobutene and water.
Patent EP-3987025-A1 (EP)
Inventor: LIN DA
IPC: C12N15/66
Filed: 2020-04-02
Abstract: The invention relates to a nucleic acid comprising at least one methylation-protectable restriction element, the methylation-protectable restriction element comprising: (i) a type IIS restriction enzyme recognition sequence, or a partial type IIS restriction enzyme recognition sequence, that is recognised by a type IIS restriction enzyme that cleaves outside of the recognition sequence; (ii) a DNA methylase recognition sequence that is recognised and methylated by a DNA methylase, wherein the DNA methylase recognition sequence is identical to, or is encompassed within, the type IIS restriction recognition sequence, such that methylation of the nucleic acid by the DNA methylase methylates the type IIS restriction enzyme recognition sequence and protects the nucleic acid from cleavage by the type IIS restriction enzyme; and (iii) a recognition sequence for a sequence-specific DNA-binding protein, wherein the recognition sequence is positioned such that the binding of the sequence-specific DNA-binding protein overlaps with the DNA methylase recognition sequence such that binding of the sequence-specific DNA-binding protein is capable of preventing methylation of the type IIS restriction enzyme recognition sequence by the DNA methylase such that it is not protected from cleavage by the type IIS restriction enzyme. The invention further relates to associated methods of nucleic acid assembly.
Patent EP-3946533-A1 (EP)
Inventor: CHODKOWSKI LAUREN PATRICIA
IPC: A61M25/02
Filed: 2020-03-27
Abstract: An adhesive arrangement for use in securing a patient interface to the face of a patient includes a substrate material having a first surface that is structured to face the patient and a second surface opposite the first surface. The substrate material includes a number of tabs, each tab projecting outward from a main portion of the substrate material. The adhesive arrangement further includes an adhesive material disposed on the first surface of the substrate material. Each of the tabs is sized and configured to be folded back onto a corresponding portion of the main portion of the substrate material and coupled thereto by the adhesive material.
Patent EP-3941231-A1 (EP)
Title: Fluid transfer article
Inventor: LORD CHRIS
IPC: A61M11/04
Filed: 2020-03-17
Abstract: A fluid transfer article has a first region having an aerosol precursor and for transferring said aerosol precursor to an activation surface of a second region of said article, said activation surface being disposed at an end of said article configured for thermal interaction with a heater of an aerosol-generation apparatus, and the aerosol precursor having a first dynamic viscosity in an unheated state and a lower second dynamic viscosity in a heated state, wherein in the unheated state the aerosol precursor is substantially retained in the fluid transfer article, both at atmospheric pressure and when a pressure below atmospheric pressure is applied; and in the heated state the aerosol precursor is substantially drawn from the activation surface of said article when a pressure below atmospheric pressure is applied. Advantageously, this combination of features provides a fluid transfer article that does not substantially leak excess aerosol precursor when heated by a heating element.
Patent EP-3952631-A1 (EP)
Inventor: STEUPERAERT JAN
IPC: A01G7/06
Filed: 2020-04-09
Abstract: Disclosed is a device for the subcortical injection of a substance into a plant, comprising a body (1), a substantially straight needle (3) pierced at its centre with a channel (4) opening via at least one hole (2) on the side wall of the needle and intended to penetrate into the plant, a store (5) communicating with the needle and containing the substance to be injected, a first actuator (6) capable of mobilising the needle so as to allow it to be inserted into the plant, a second actuator (7) capable of compressing the volume of substance present in the store so as to allow this substance to be injected, the device comprising a first force sensor (8) associated with the body allowing the bearing force applied by the device to the plant to be measured, a second force sensor (9) associated with the first actuator allowing the insertion force with which the needle is inserted into the plant to be measured; a third force sensor (10) allowing the pressurising force with which the volume of substance present in the store is pressurised to be measured, and at least one microcontroller that only allows the first actuator to be activated if the first force sensor detects a bearing force, that modulates the activation of the first actuator, and therefore the injection of the needle into the plant, depending on the insertion force measured by the second force sensor, and that modulates the compression of the volume of substance present in the store, and therefore the injection of this substance into the plant, depending on the force measured by the third force sensor.
Patent EP-3970130-A1 (EP)
Title: Driving assistance system and lane change determining unit and method thereof
Inventor: SUN GAO
IPC: G08G1/01
Filed: 2020-04-20
Abstract: The present application proposes a lane change determining unit for use in a driving assistance system, comprising: an acquisition module, configured to acquire information containing travelling states of a principal vehicle and a vehicle in the vicinity thereof; a processing module, configured to determine a lane traffic efficiency of each lane on the basis of the information acquired by the acquisition module, the processing module calculating and assessing a driving mood of a target vehicle in the vicinity on the basis of the acquired travelling state thereof, and the processing module being further configured to determine a first lane change probability value of the target vehicle on the basis of the lane traffic efficiency and the driving mood of the target vehicle; and a generating module, configured to generate a lane change intention signal indicating a lane change intention of the target vehicle on the basis of the first lane change probability value, to assist the driving of the principal vehicle.