Patent SG-11201807021U-A (SG)
Title: Heteroaryl inhibitors of pad4
Inventor: DEVRAJ RAJESH
IPC: C07D471/04
Filed: 2017-02-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11 M1111101110101011111 HO 1111101110101110111010110101 1111110111011# International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date .... ...,,, WO 2017/147102 Al 31 August 2017 (31.08.2017) WIPO I PCT (51) International Patent Classification: Drive, Milton Park; Abingdon Oxfordshire OX14 4RZ CO7D 401/14 (2006.01) A61P 35/00 (2006.01) (GB). PAPADOPOULOS, Kostas; 114 Innovation Drive, CO7D 471/04 (2006.01) CO7D 417/14 (2006.01) Milton Park; Abingdon Oxfordshire OX14 4RZ (GB). A61K 31/4184 (2006.01) TYE, Heather; 114 Innovation Drive, Milton Park; Abing- (21) International Application Number: don Oxfordshire OX14 4RZ (GB). WOODS, Philip A.; PCT/US2017/018790 114 Innovation Drive, Milton Park; Abingdon Oxfordshire OX14 4RZ (GB). (22) International Filing Date: 22 February 2017 (22.02.2017) (74) Agents: REID, Andrea L.C. et al.; One International Place, 40th Floor, 100 Oliver Street, Boston, Massachu- (25) Filing Language: English setts 02110-2605 (US). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (30) Priority Data: 62/298,726 23 February 2016 (23.02.2016) US AO, BZ, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (71) Applicant: PADLOCK THERAPEUTICS, INC. [US/US]; Route 206 & Province Line Road, Princeton, New Jersey 08543-4000 (US). DO, HN, KP, MD, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, _ (72) Inventors: DEVRAJ, Rajesh; 301 Palomino Hill Court, Chesterfield, Missouri 63005 (US). KUMARAVEL, Gna- nasambandam; 21 Appletree Lane, Lexington, Massachu- setts 02420 (US). ATTON, Holly; 114 Innovation Drive, Milton Park; Abingdon Oxfordshire OX14 4RZ (GB). NI, RU, TH, ZA, ZM, ZW. NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, BEAUMONT, Edward; 114 Innovation Drive, Milton (84) Designated States (unless otherwise indicated, for every Park; Abingdon Oxfordshire OX14 4RZ (GB). GADOULEAU, Elise; 114 Innovation Drive, Milton Park; Abingdon Oxfordshire OX14 4RZ (GB). GLEAVE, Laura; 114 Innovation Drive, Milton Park; Abingdon Ox- kind GM, TZ, TJ, of regional protection available): ARIPO (BW, GH, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, = = . fordshire OX14 4RZ (GB). KERRY, Philip Stephen; 114 Innovation Drive, Milton Park; Abingdon Oxfordshire OX14 4RZ (GB). LECCI, Cristina; 114 Innovation Drive, Milton Park; Abingdon Oxfordshire OX14 4RZ (GB). DK, LV, SM, GW, KM, ML, MR, NE, SN, TD, TG). EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = = — = MENICONI, Mirco; 114 Innovation Drive, Milton Park; Published: = Abingdon Oxfordshire OX14 4RZ (GB). MONCK, Nat; 114 Innovation Drive, Milton Park; Abingdon Oxfordshire OX14 4RZ (GB). PALFREY, Jordan; 114 Innovation — with international search report (Art. 21(3)) = = = = = = = 1-1 ei © ,-1 IN ii- ,-1 IN ,-1 © ei (54) Title: HETEROARYL INHIBITORS OF PAD4 C ) --, (57) : The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treat- ing PAD4-related disorders.