Patent SG-11201407796Y-A (SG)
Title: Chromane compounds
Inventor: MUNAKATA RYOSUKE
IPC: C07D263/52
Filed: 2013-05-29
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 5 December 2013 (05.12.2013) WIPOIPCT (10) International Publication Number WO 2013/181202 A3 (51) International Patent Classification: A61K31/352 (2006.01) C07D 263/52 (2006.01) (21) International Application Number: (74) Agents: BOLIN, Kimberly, A. et al.; Morrison & Foerster LLP, 755 Page Mill Road, Palo Alto, CA 94304-1018 (US). (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/653,321 61/782,038 30 May 2012 (30.05.2012) 14 March 2013 (14.03.2013) (71) Applicants: ASTELLAS PHARMA INC. [ JP/JP] ; 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, 103-8411 (JP). COMENTIS, INC. [US/US]; 280 Utah Avenue, Suite 275, South San Francisco, CA 94080 (US). (72) Inventors: MUNAKATA, Ryosuke; c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, 103-8411 (JP). INOUE, Makoto; c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, 103- 8411 (JP). TOMINAGA, Hiroaki; c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, 103-8411 (JP). YAMASAKI, Shingo; c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, — 103-8411 (JP). SHIINA, Yasuhiro; c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, 103-8411 (JP). SAMIZU, Kiyohiro; c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, 103-8411 (JP). HAMAGUCHI, Hisao; c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, 103-8411 (JP). HONG, Lin; 15613 Sugar Loaf Drive, Edmond, OK 73013 (US). PCT/US2013/043016 (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 29 May 2013 (29.05.2013) English English US US (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 30 January 2014 CJ o CJ i-H 00 i-H en i-H o CJ (54) Title: CHROMANE COMPOUNDS (57) Abstract: The present invention provides a compound which useful is as an active ingredient of a pharmaceutical composition, in particular, pharmaceutical composition a for preventing or treating diseases or conditions associated with and/or mediated by (3- secretase activity, hydrolysis of a (3-secretase site of a (3 -amyloid precursor protein, and/or (3 -amyloid protein accumulation, includ­ ing pharmaceutical composition a for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.