Patent SG-11201808214T-A (SG)
Title: Pyrazolopyrimidine derivatives
Inventor: KÖHLER ADELINE
IPC: A61P33/10
Filed: 2017-04-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 HO 111110111010 MINIUM I In III International Bureau 0.. .... .. ..... ..or::,,, (10) International Publication Number (43) International Publication Date WO 2017/178416 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: str. 22, 51067 Köln (DE). BOHM, Claudia; Im Seefelde C07D 487/02 (2006.01) A61P 33/10 (2006.01) 4a, 30457 Hannover (DE). A61K 31/519 (2006.01) (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 (21) International Application Number: Monheim am Rhein (DE). PCT/EP2017/058519 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 10 April 2017 (10.04.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 16165572.5 15 April 2016 (15.04.2016) EP NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (71) Applicant: BAYER ANIMAL HEALTH GMBH RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, [DE/DE]; Kaiser-Wilhelm-Allee 10, 51373 Leverkusen TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (DE). ZA, ZM, ZW. (72) Inventors: KOHLER, Adeline; Heimchenweg 9, 40764 (84) Designated States (unless otherwise indicated, for every Langenfeld (DE). WELZ, Claudia; Calvinstr. 19, 40597 kind of regional protection available): ARIPO (BW, GH, Diisseldorf (DE). BORNGEN, Kirsten; Feldhasenweg 23, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, — 50859 Köln (DE). KULKE, Daniel; Dillinger Str. 13, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, — 51375 Leverkusen (DE). ILG, Thomas; Plotzenseer TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, — KOBBERLING, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Strasse 16, 40789 Monheim (DE). Jo- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, hannes; Azalienstr. 30, 41466 Neuss (DE). HUBSCH, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = Walter; Wildsteig 22, 42113 Wuppertal (DE). SCHWARZ, Hans-Georg; Auf dem Beerenkamp 82b, GW, KM, ML, MR, NE, SN, TD, TG). 46282 Dorsten (DE). GORGENS, Ulrich; Fester Str. 37, Declarations under Rule 4.17: — 40882 Ratingen (DE). EBBINGHAUS-KINTSCHER, = — as to applicant's entitlement to apply for and be granted a Ulrich; Wittbraucker Str. 122, 44287 Dortmund (DE). patent (Rule 4.1700) HINK, Maike; Blumenstr. 56, 71706 Markgroningen = (DE). NENNSTIEL, Dirk; Lupusstr. 30, 50670 Köln Published: _ (DE). RAMING, Klaus; Lortzingstr. 35, 51375 with international search report (Art. 21(3)) = Leverkusen (DE). ADAMCZEWSKI, Martin; Andersen- = = = = = (54) Title: PYRAZOLOPYRIMIDINE DERIVATIVES 1-1 4 N ----. '\" ...... 'N YA K ,tD R R 2 0 (I) 1-1 iv cc IN ,—, Q IN 1-1 (57) : The present invention covers Pyrazolopyrimidine compounds of 0 R 2 , R 3 and R 4 are as defined herein, methods of \" pounds, pharmaceutical compositions and combinations C ing pharmaceutical compositions for the treatment, sole agent or in combination with other active ingredients. ....\" N preparing control comprising said compounds 1 R 3 R said compounds, intermediate and/or prevention of general formula and the use of said compounds for manufactur- diseases, compounds Ro (I), in which n, o, X, Y, R, Q, R', useful for preparing said cam- in particular of helminth infections, as a